BI 2536

目录号:S1109

BI 2536 Chemical Structure

Molecular Weight(MW): 521.66

BI 2536是一种有效的Plk1抑制剂,无细胞试验中IC50为0.83 nM,比作用于Plk2和Plk3选择性分别高4和11倍。Phase 2。

规格 价格 库存 购买数量  
RMB 1978.87 现货
RMB 981.57 现货
RMB 1704.35 现货
RMB 5492.59 现货
RMB 8160.83 现货
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产品安全说明书

PLK抑制剂选择性比较

生物活性

产品描述 BI 2536是一种有效的Plk1抑制剂,无细胞试验中IC50为0.83 nM,比作用于Plk2和Plk3选择性分别高4和11倍。Phase 2。
特性 BI 2536是第一个有效的Plk1选择性抑制剂,抑制 Plk1的标记。
靶点
PLK1 [1]
(Cell-free assay)
PLK2 [1]
(Cell-free assay)
PLK3 [1]
(Cell-free assay)
0.83 nM 3.5 nM 9.0 nM
体外研究

除了Plk1, BI 2536也抑制 Plk2 和Plk3活性,只是抑制程度低点,IC50分别为3.5 nM和9.0 nM。BI 2536比一组63种其他蛋白激酶(IC50>10 μM)选择性高1000多倍。BI 2536 按10 nM 到 100 nM剂量作用于HeLa细胞,抑制有丝分裂中心体中γ-微管蛋白招募和Apc6 磷酸化,抑制染色体臂中释放黏结蛋白, 诱导产生单极主轴,及一些依赖Plk1的其他有丝分裂过程。与作用于Plk1 RNAi效果相一致, BI 2536处理HeLa细胞,使细胞周期停在G2/M期, 随后DNA分解及凋亡,且累积断裂的PARP p85片段,这种作用存在浓度依赖性。BI 2536抑制一组32种人肿瘤细胞系生长,EC50为2-25 nM,抑制指数生长的hTERT-RPE1,人脐静脉内皮细胞 (HUVECs),和正常大鼠肾脏(NRK) 细胞的增殖,EC50为12-31 nM。[1] BI 2536 抑制Plk1,降低甲状腺未分化癌(ATC)细胞如 CAL62, OCUT-1, SW1736, 8505C,和 ACT-1 的生长的生长和活力,EC50为1.4-5.6 nM。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PSN1 NVTVd2dPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwMEC3O|Yh|ryP MmjKV2FPT0WU
ACN M3vNUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TadWlEPTB;MD6wNFg1OyEQvF2= MYDTRW5ITVJ?
TE-8 M4nMR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrFTWM2OD1yLkCwPVQyKM7:TR?= NYrZbXp1W0GQR1XS
LC-2-ad MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYOw[|NCUUN3ME2wMlAyODl|IN88US=> MmfKV2FPT0WU
ALL-PO MkLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrnfHVlUUN3ME2wMlAyOyEQvF2= MnvpV2FPT0WU
EW-16 NF;RRVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn:1TWM2OD1yLkCxN|M3KM7:TR?= MX7TRW5ITVJ?
KM12 NGW2fJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrrTWM2OD1yLkCxN|Q5KM7:TR?= Mon5V2FPT0WU
GI-1 M2XD[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwMEGzPFMh|ryP M1;YWnNCVkeHUh?=
LS-411N M3n2e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfqOFNKSzVyPUCuNFE1ODdizszN NVvh[ph3W0GQR1XS
ES8 NYTtT4dMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHkdGRjUUN3ME2wMlAyPDl2IN88US=> MVjTRW5ITVJ?
SNU-C2B MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrVb|hiUUN3ME2wMlAyPTJ4IN88US=> Mn;mV2FPT0WU
CESS MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXDSVhJUUN3ME2wMlAyPjB{IN88US=> M2nadnNCVkeHUh?=
697 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwMEG2Olgh|ryP NGKzXJpUSU6JRWK=
NCI-H1963 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TsSWlEPTB;MD6wNVY4OyEQvF2= NVHYe3NMW0GQR1XS
IA-LM MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTSZ2czUUN3ME2wMlAyPjh6IN88US=> NGfKVZRUSU6JRWK=
SW954 NWT2R4Z4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTQW29KSzVyPUCuNFE4ODVizszN NHvNNWZUSU6JRWK=
RL95-2 M{nrcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2faNmlEPTB;MD6wNVc{QCEQvF2= MYLTRW5ITVJ?
LXF-289 NITXdIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWOxRWFoUUN3ME2wMlAyPzdizszN NID1[JNUSU6JRWK=
OCUB-M NWm2Rm13T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwMEG4NlYh|ryP MWTTRW5ITVJ?
RKO M{XhNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnKxTWM2OD1yLkCxPVg4KM7:TR?= M17NRnNCVkeHUh?=
LOUCY MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrQfnZyUUN3ME2wMlAzODVizszN MmnqV2FPT0WU
NOS-1 M1n1bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3SyN2lEPTB;MD6wNlA6OyEQvF2= MnrPV2FPT0WU
A4-Fuk MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnK[FVKSzVyPUCuNFIzOThizszN NF;vPJZUSU6JRWK=
A388 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrCXYNpUUN3ME2wMlAzOjJ5IN88US=> NVPjdXBDW0GQR1XS
TE-9 M4fmfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nIVWlEPTB;MD6wNlI3OSEQvF2= MlT5V2FPT0WU
KURAMOCHI Mn\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHnTWM2OD1yLkCyNlg2KM7:TR?= NVOzOGpKW0GQR1XS
KALS-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\kVGlEPTB;MD6wNlM{QCEQvF2= NIfNbHBUSU6JRWK=
HOP-62 NGXtT4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHH5WGtKSzVyPUCuNFI1OiEQvF2= NH;PVIpUSU6JRWK=
RPMI-8402 NHO0TodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfkfGRKSzVyPUCuNFI2ODhizszN M3v2SXNCVkeHUh?=
TE-1 M371cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HtdWlEPTB;MD6wNlUyOiEQvF2= NYPtelY1W0GQR1XS
CCRF-CEM NFvJXVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTBwMEK1OFMh|ryP MYfTRW5ITVJ?
HUTU-80 MoPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXPc5FIUUN3ME2wMlAzPjJ2IN88US=> MljOV2FPT0WU
NCI-H1648 NYT5PZliT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlG2TWM2OD1yLkCyOlQ4KM7:TR?= NWXNSoFLW0GQR1XS
HCE-4 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XLSmlEPTB;MD6wNlY5OiEQvF2= NVv0dmt7W0GQR1XS
ETK-1 NHT3SXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nSWmlEPTB;MD6wNlc{PiEQvF2= NW\xOoczW0GQR1XS
TE-15 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTBwMEK3N|gh|ryP Mn\JV2FPT0WU
BE-13 MmnVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3r6N2lEPTB;MD6wNlc1KM7:TR?= MWPTRW5ITVJ?
KE-37 M3PvOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLwTWM2OD1yLkCyO|QyKM7:TR?= MXvTRW5ITVJ?
NCI-H1355 M2OyT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjJTWM2OD1yLkCyO|g{KM7:TR?= NX20WFVbW0GQR1XS
TE-11 M33Ec2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnnTWM2OD1yLkCyPFA6KM7:TR?= M1zFUXNCVkeHUh?=
BL-70 NVrkXZdWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwMEK4OVch|ryP MXHTRW5ITVJ?
ES6 M12zUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorNTWM2OD1yLkCyPFgyKM7:TR?= M4K2c3NCVkeHUh?=
GT3TKB Mn;vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\GTVF5UUN3ME2wMlAzQTV|IN88US=> NVy0TnJVW0GQR1XS
LB647-SCLC Ml3FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwMEOxPVUh|ryP NUHFTmRbW0GQR1XS
NB13 NVv3VFE3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnrTnZKSzVyPUCuNFM{OTZizszN M3fMfnNCVkeHUh?=
ST486 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XXWGlEPTB;MD6wN|M{PyEQvF2= MUHTRW5ITVJ?
NCI-H82 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwMEOzOFMh|ryP MkPYV2FPT0WU
NTERA-S-cl-D1 M3fVdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfnZpRKSzVyPUCuNFM{QTlizszN Mn3qV2FPT0WU
ES4 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{m1eGlEPTB;MD6wN|Q3OyEQvF2= MUPTRW5ITVJ?
SK-NEP-1 Mn;TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnqeGVJUUN3ME2wMlA{PDl7IN88US=> M3HWN3NCVkeHUh?=
Becker Mmm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\4XFh3UUN3ME2wMlA{PTV3IN88US=> M2HaTXNCVkeHUh?=
A101D MoTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTBwMEO3OFgh|ryP M{fz[XNCVkeHUh?=
SK-UT-1 NVzxbop6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXL0VXRCUUN3ME2wMlA{Pzd2IN88US=> MY\TRW5ITVJ?
SW982 NWPaTWYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXCTWM2OD1yLkCzO|kh|ryP M1jWfXNCVkeHUh?=
TE-10 M2rySmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\UNVlKSzVyPUCuNFQxPDZizszN M2LGRnNCVkeHUh?=
OVCAR-4 M{L2dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml6wTWM2OD1yLkC0NFU6KM7:TR?= NEK3UWtUSU6JRWK=
KP-N-YS NULNToxqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jUWWlEPTB;MD6wOFA5PSEQvF2= NUPjNIJnW0GQR1XS
BL-41 NWr4Z2RpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILUfWdKSzVyPUCuNFQyOjVizszN MXzTRW5ITVJ?
MZ1-PC M1rlVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zNSmlEPTB;MD6wOFEzPyEQvF2= NFvPfZFUSU6JRWK=
PF-382 NWf6UnVMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwMESxPVgh|ryP NYrwW3FIW0GQR1XS
MOLT-13 NES5eVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEn6cIRKSzVyPUCuNFQzOzhizszN MVrTRW5ITVJ?
HCC1599 NGTT[nNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rFXGlEPTB;MD6wOFI2QCEQvF2= M{[1enNCVkeHUh?=
IST-MEL1 MkD2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwMES0OFIh|ryP NVHRbmtkW0GQR1XS
LU-139 NX\SOmltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTBwMES0OFIh|ryP MUjTRW5ITVJ?
MS-1 NX3USXpQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDOTWM2OD1yLkC0O|AyKM7:TR?= NUHRXY97W0GQR1XS
MFH-ino MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW[0TohFUUN3ME2wMlA2ODB|IN88US=> MXHTRW5ITVJ?
IMR-5 NUnUVFIzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXEVoVKSzVyPUCuNFUxOjFizszN NW\JNpF5W0GQR1XS
TE-5 NEPKRZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofRTWM2OD1yLkC1NFY{KM7:TR?= MWLTRW5ITVJ?
DJM-1 M1HvfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3K0W2lEPTB;MD6wOVE1OiEQvF2= MojHV2FPT0WU
NB17 MoW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjLdVBKSzVyPUCuNFUzODdizszN M2DjV3NCVkeHUh?=
KARPAS-45 NGHqPJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfrTWM2OD1yLkC1N|U5KM7:TR?= NIG0OYFUSU6JRWK=
TGBC1TKB NFfjWVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\RUmlEPTB;MD6wOVQxPSEQvF2= MXPTRW5ITVJ?
ML-2 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDQOXFKSzVyPUCuNFU1OTRizszN NUDiRpd{W0GQR1XS
no-10 M1PaT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4S4d2lEPTB;MD6wOVQ4PCEQvF2= M4DsXXNCVkeHUh?=
CTV-1 M17HUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\oTJZwUUN3ME2wMlA2PTB{IN88US=> M3\xZ3NCVkeHUh?=
SJSA-1 NUfVWFFIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvkU4NKSzVyPUCuNFU2OiEQvF2= NHTi[VJUSU6JRWK=
HC-1 MkfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYK5[JVmUUN3ME2wMlA2PTl5IN88US=> MmriV2FPT0WU
TE-12 MnrYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPETWM2OD1yLkC1OlE{KM7:TR?= NIPzdW5USU6JRWK=
KY821 M3H4Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrSTWM2OD1yLkC1OlMzKM7:TR?= MlTsV2FPT0WU
TALL-1 NV;uNGNCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3GTWM2OD1yLkC1O|A5KM7:TR?= NGrl[FBUSU6JRWK=
DEL MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHETWM2OD1yLkC1O|A6KM7:TR?= Mn3OV2FPT0WU
TE-6 NEnMcFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVux[HE2UUN3ME2wMlA2PzJ{IN88US=> NHXyR2RUSU6JRWK=
SK-LMS-1 NH3aPJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;rZWlEPTB;MD6wOVgxPSEQvF2= M1HpfnNCVkeHUh?=
EW-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjCPFRIUUN3ME2wMlA2QDN5IN88US=> MlWxV2FPT0WU
8-MG-BA M3[zNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{O4SmlEPTB;MD6wOVg2OSEQvF2= NUjmO3lzW0GQR1XS
NALM-6 M{Tqfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfYWZhKSzVyPUCuNFU6PzNizszN NICxW5pUSU6JRWK=
LB771-HNC MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7HdJlKSzVyPUCuNFU6PzlizszN M2\rOHNCVkeHUh?=
HT-144 M4LKVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTBwME[xN{DPxE1? NXrRT5hNW0GQR1XS
KM-H2 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rXb2lEPTB;MD6wOlIzOSEQvF2= M1;wTHNCVkeHUh?=
SF268 NFuxOZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVX4dFA3UUN3ME2wMlA3Ojh4IN88US=> MlvjV2FPT0WU
RS4-11 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrtfYxnUUN3ME2wMlA3OzB2IN88US=> M3jXVHNCVkeHUh?=
MHH-PREB-1 NEHhW3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PWeGlEPTB;MD6wOlMyQSEQvF2= MoDQV2FPT0WU
ATN-1 M2nHTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwME[zOFUh|ryP MWrTRW5ITVJ?
BB30-HNC NHjab|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TVfWlEPTB;MD6wOlQ{PiEQvF2= M1zrW3NCVkeHUh?=
CPC-N M2jmSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTBwME[1NlQh|ryP M4fRNnNCVkeHUh?=
NB1 M33vUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDOOYJKSzVyPUCuNFY3OTNizszN M3zydnNCVkeHUh?=
KS-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPJTWM2OD1yLkC2O|Q5KM7:TR?= MlzXV2FPT0WU
RXF393 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;3cpBIUUN3ME2wMlA3PzZ2IN88US=> M{\GdHNCVkeHUh?=
IST-SL2 MlHkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfpVJA1UUN3ME2wMlA4ODB2IN88US=> MUPTRW5ITVJ?
GI-ME-N MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTrfJZKSzVyPUCuNFczQDZizszN MV\TRW5ITVJ?
VA-ES-BJ MkTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoT4TWM2OD1yLkC3OFc2KM7:TR?= Mn25V2FPT0WU
NCI-H1581 NITMSopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLVTWM2OD1yLkC3OFc5KM7:TR?= MUnTRW5ITVJ?
U-266 M4fhOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLiTWM2OD1yLkC3OFk4KM7:TR?= NF;aU3JUSU6JRWK=
DMS-114 NV3YPGs4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYW0XJF4UUN3ME2wMlA4PTJ6IN88US=> NYLzWIZ3W0GQR1XS
NCI-H187 NWSzVVBRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwMEe3NlYh|ryP NX:0ZpZtW0GQR1XS
SW962 M2fL[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrUS4xJUUN3ME2wMlA4QDN7IN88US=> MoTqV2FPT0WU
MONO-MAC-6 NVK1e5k3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnr5TWM2OD1yLkC3PVg3KM7:TR?= NXLsTWl2W0GQR1XS
MOLT-16 NIG1ZotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfGTWM2OD1yLkC4NVIyKM7:TR?= M1zWO3NCVkeHUh?=
KNS-42 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfzWG9iUUN3ME2wMlA5OTZzIN88US=> M2\lbnNCVkeHUh?=
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NOMO-1 NXfXbXFPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTBwNEO4OkDPxE1? MX\TRW5ITVJ?
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COLO-668 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXPWVljUUN3ME2wMlQ2PjZ6IN88US=> NUDoPItMW0GQR1XS
SF539 M3zROGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWG3bHV4UUN3ME2wMlQ5Pjh2IN88US=> MUXTRW5ITVJ?
LB2518-MEL NWjZdWN6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTBwNEm3NFMh|ryP MWXTRW5ITVJ?
TE-441-T NFjrNW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmm5TWM2OD1yLkWwNVIh|ryP MYfTRW5ITVJ?
MDA-MB-134-VI Mmm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLKTWM2OD1yLkWwPVIyKM7:TR?= M3XZe3NCVkeHUh?=
SCC-3 M2X6Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwNUG4O|Mh|ryP NYDJV5BkW0GQR1XS
KLE Mn7tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkf5TWM2OD1yLkWyNVcyKM7:TR?= Mnv0V2FPT0WU
LB2241-RCC Mli5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTBwNUK1NlUh|ryP MoD4V2FPT0WU
NCI-H1417 NFXNVFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\lfG1KSzVyPUCuOVM1OzVizszN M1XGNHNCVkeHUh?=
NCI-H2081 M3jzSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTBwNUi2NVEh|ryP MlHJV2FPT0WU
NCI-H1522 NEnzNGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmGwTWM2OD1yLkW5N|g{KM7:TR?= NU\UfpJSW0GQR1XS
NCI-H889 MkCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnPR29KSzVyPUCuOVk5PDRizszN MYTTRW5ITVJ?
CGTH-W-1 NGLRcY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1Swb2lEPTB;MD62NFc2PSEQvF2= NEDodYhUSU6JRWK=
EB-3 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvRbpBKSzVyPUCuOlEyPTNizszN M1G1O3NCVkeHUh?=
D-336MG Mn3jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEG5SFhKSzVyPUCuOlE4QTFizszN M{DmS3NCVkeHUh?=
LC-1F M4nZSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\G[mlEPTB;MD62NlU6OiEQvF2= M1XmPHNCVkeHUh?=
MHH-NB-11 M3HXXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\wUHdKUUN3ME2wMlY{QDBzIN88US=> MWHTRW5ITVJ?
SK-N-FI M3LaeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTBwNkO5NUDPxE1? NF3yNoxUSU6JRWK=
NCI-H69 M1vNXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHPTWM2OD1yLk[0PFc6KM7:TR?= NX\CWZBoW0GQR1XS
SCH M4PBeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwNk[wNlMh|ryP NGWySmFUSU6JRWK=
LS-513 MnHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwNkeyOVkh|ryP MWfTRW5ITVJ?
CP67-MEL Mn;sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjVW2syUUN3ME2wMlY4PTl4IN88US=> M{f4VnNCVkeHUh?=
GCIY MmXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwN{CzOlMh|ryP NUHQUnNmW0GQR1XS
SHP-77 MnnSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTBwN{C3N|Qh|ryP M{HmTnNCVkeHUh?=
EHEB M3qwVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4H0fGlEPTB;MD63NVg2PCEQvF2= M3ezZXNCVkeHUh?=
D-247MG MlPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoqwTWM2OD1yLkezNlMzKM7:TR?= MmXQV2FPT0WU
Raji NHPIfGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;wWmNKSzVyPUCuO|Q6QDlizszN M1flWXNCVkeHUh?=
MPP-89 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzjcJlGUUN3ME2wMlc2QTd6IN88US=> M3m1U3NCVkeHUh?=
EKVX Mlm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFuyNGtKSzVyPUCuO|kxPzNizszN NGDxOYZUSU6JRWK=
HCC2218 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwN{mxN|Eh|ryP NVnDPG5oW0GQR1XS
KNS-81-FD MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1frRmlEPTB;MD64NVAyOSEQvF2= MnLZV2FPT0WU
HCC2157 MnroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwOES5OVEh|ryP M{\QdHNCVkeHUh?=
BT-474 MkfFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4Hp[WlEPTB;MD64PFg2PCEQvF2= NHeydnpUSU6JRWK=
NCI-H748 NV7jXHBoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTBwOUGyJO69VQ>? M{PkRXNCVkeHUh?=
EW-24 MluyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LiPWlEPTB;MD65NlAxOiEQvF2= MoqwV2FPT0WU
D-263MG MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnETWM2OD1yLkm0OVEzKM7:TR?= MXXTRW5ITVJ?
OMC-1 NHv0OY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfubmd6UUN3ME2wMlk3Ozd|IN88US=> NI\3PWdUSU6JRWK=
NCI-H2196 NYLsRXhyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4[xSGlEPTB;MD65O|c4PyEQvF2= M{DpbXNCVkeHUh?=
HAL-01 MkmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPLTWM2OD1yLkm5PFczKM7:TR?= NHXaZlRUSU6JRWK=
NCI-H2107 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTFwMEG4OVQh|ryP NV:5cWh4W0GQR1XS
LB996-RCC MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY[wOVhNUUN3ME2xMlA5ODVzIN88US=> M3Kz[XNCVkeHUh?=
NCI-H1395 NUTPXY5YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInoT4lKSzVyPUGuNVA3PyEQvF2= NUjxOVA3W0GQR1XS
CHP-126 M3PyXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVyxTlc2UUN3ME2xMlE3OTl7IN88US=> M4LIb3NCVkeHUh?=
NB69 NUPJdpVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVi3O5hlUUN3ME2xMlI3OTR6IN88US=> MWrTRW5ITVJ?
CAS-1 M2jDZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTFwM{SyN|Eh|ryP M3\MZXNCVkeHUh?=
JVM-3 NGqxPFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LUc2lEPTB;MT60O|g2PSEQvF2= MmW3V2FPT0WU
DMS-153 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7aRo1KSzVyPUGuOVc3PzRizszN NEfldnNUSU6JRWK=
SK-MEL-2 NWXudWFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTFwN{G3PFkh|ryP NW\TR3pXW0GQR1XS
NCI-H1155 NYfV[Zk4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEi1bm5KSzVyPUGuO|M3PzZizszN NGfRVlVUSU6JRWK=
NCI-H1092 NHHXboRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\oVlBJUUN3ME2xMlc3OTh{IN88US=> NFe5fJVUSU6JRWK=
LU-165 NXXycnE4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTITWM2OD1zLki2OFc3KM7:TR?= NW\ZNXRyW0GQR1XS
HL-60 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\TSolKSzVyPUGuPVk6ODhizszN MUTTRW5ITVJ?
REH MnPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2T6W2lEPTB;Mj6wNFU5OiEQvF2= NE\Z[4lUSU6JRWK=
JVM-2 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PuXWlEPTB;Mj6wOlE{PSEQvF2= NFX0blVUSU6JRWK=
MN-60 M1HmNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofMTWM2OD1{LkG3N|A5KM7:TR?= NFjsXXZUSU6JRWK=
SCC-15 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXOTWM2OD1{LkKwNlch|ryP NFvFcmdUSU6JRWK=
SNU-C1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1Lh[mlEPTB;Mj6yNVM1OyEQvF2= M4jx[nNCVkeHUh?=
SK-MEL-1 M1fUNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH:5[5RKSzVyPUKuN|IxPDdizszN MXzTRW5ITVJ?
TGW MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXWTWM2OD1{LkO1NFI4KM7:TR?= MXnTRW5ITVJ?
CA46 NYPLe2tuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\hU|dKSzVyPUKuO|U6PjdizszN MULTRW5ITVJ?
NCI-H23 NFXsOplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTMTFJ6UUN3ME2yMlgxPzlzIN88US=> NUD4dmVsW0GQR1XS
MMAC-SF M2XnXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLrWGVvUUN3ME2yMlg3PjJ6IN88US=> NX3BeItvW0GQR1XS
NCI-H2171 Ml6yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVT0Z3JjUUN3ME2zMlA{PDR6IN88US=> NF60UFVUSU6JRWK=
A704 MnzaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTNwMUSxPVQh|ryP M3\vR3NCVkeHUh?=
DB NUn3VIQ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\4RmlEPTB;Mz6yOVU4PiEQvF2= NXTNTYdJW0GQR1XS
NCI-H719 NH;t[YlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17JfWlEPTB;Mz6zNFM5PCEQvF2= NXPH[pB[W0GQR1XS
MC-CAR NECweW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\TcGlEPTB;Mz61OFgyPyEQvF2= MVLTRW5ITVJ?
SIMA NYjoeoZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{Hyb2lEPTB;Mz61PFQyPiEQvF2= NFjHSIZUSU6JRWK=
SW872 MlrJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF25c4lKSzVyPUOuO|gyODFizszN M1;KWnNCVkeHUh?=
HCC1187 NI\nd5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUm3VHNWUUN3ME2zMlc5OzF3IN88US=> MoPNV2FPT0WU
EW-13 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTNwOEO0NVch|ryP NWPGdWxKW0GQR1XS
NCI-SNU-1 M3XoTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4joeGlEPTB;ND6yNVk6QSEQvF2= M1rHdXNCVkeHUh?=
NCI-H226 Mm\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTRwM{O2NFYh|ryP M{XucnNCVkeHUh?=
RPMI-8866 NX\Mb3VrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHBTWM2OD12LkO2NFI6KM7:TR?= M3vEW3NCVkeHUh?=
OCI-AML2 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETrWYZKSzVyPUSuOVUzOyEQvF2= M1:2eXNCVkeHUh?=
LU-65 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvVUotLUUN3ME20Mlk{ODN|IN88US=> MXHTRW5ITVJ?
SK-N-DZ M2fVcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTVwNkO0OlUh|ryP NUPHS|ZKW0GQR1XS
NB14 MnHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\HTWM2OD13Lkm3NVM2KM7:TR?= Mn7DV2FPT0WU
COLO-829 M2jwXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTZwM{OzOVkh|ryP MnHiV2FPT0WU
MHH-CALL-2 M{P1d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrCU4VUUUN3ME22MlUyPTB6IN88US=> MU\TRW5ITVJ?
NCI-H1770 NUfGSXNrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLiTWM2OD14Lk[2PVA1KM7:TR?= NE\TeZdUSU6JRWK=
ECC4 M{Hufmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHSy[FJKSzVyPU[uPFIyPzlizszN NH;aVHJUSU6JRWK=
A498 M2jNU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTZwOEexPVIh|ryP NIjoeFdUSU6JRWK=
DMS-79 MkHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDyTWM2OD15LkC0OVEzKM7:TR?= M{PSZ3NCVkeHUh?=
P30-OHK NXz0R|k6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fZT2lEPTB;Nz6yNVkxPiEQvF2= MlLUV2FPT0WU
D-502MG MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPMc3NKSzVyPUeuPVg{PiEQvF2= M1fNUHNCVkeHUh?=
RCC10RGB MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4G0NGlEPTB;OD6wOlI5KM7:TR?= MXLTRW5ITVJ?
U-698-M Mn\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEi2WIlKSzVyPUiuNlkzOjZizszN NWfqUnUzW0GQR1XS
BB49-HNC MnjuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7aTWM2OD17LkSyNlY2KM7:TR?= NWPwWXRDW0GQR1XS
ES1 MlLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nQemlEPTB;OT62PFk2PiEQvF2= NHHuVm9USU6JRWK=
MFM-223 MoHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zwVWlEPTB;MUCuPVkzPyEQvF2= NG\6bVBUSU6JRWK=
C2BBe1 NYr4c4xjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\UUFFKSzVyPUGxMlM2OjNizszN M1n4UHNCVkeHUh?=
EB2 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoKzTWM2OD1zMj62PFgyKM7:TR?= NGXHSWpUSU6JRWK=
C8166 NW\hTFEyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTF|LkizNFMh|ryP NITj[XNUSU6JRWK=
ES3 NWHzZ4tET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDqTWM2OD1zMz65PVc4KM7:TR?= NX;HfXVEW0GQR1XS
NCI-H1650 NIrx[GxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDQcXVyUUN3ME2xOk4{PzZ3IN88US=> M2\abXNCVkeHUh?=
Mo-T Mn7KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHiTpBmUUN3ME2xO{41ODJ7IN88US=> NYPGT3h4W0GQR1XS
NB7 NEmxU3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfjTWM2OD1zNz63OFY4KM7:TR?= MlnFV2FPT0WU
ES7 NELaNlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDQTWM2OD1zOT61OVA4KM7:TR?= NIjvXWJUSU6JRWK=
ES5 Mo\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLhXmtKSzVyPUKxMlc3PzFizszN M2\a[HNCVkeHUh?=
MSTO-211H M1\YU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvCWZNrUUN3ME2yNU45QDV6IN88US=> M3rFPXNCVkeHUh?=
U-87-MG MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTJ3LkG5OlYh|ryP Mo\5V2FPT0WU
THP-1 NEH5SoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\Jdm5KSzVyPUK5MlczODFizszN MXHTRW5ITVJ?
NB10 MlXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPmb4VxUUN3ME2zNE4zPjl2IN88US=> NV;pd3BNW0GQR1XS
NH-12 MlLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPmRm5rUUN3ME2zN{4zODF5IN88US=> M13veHNCVkeHUh?=
COLO-824 NEjuZ|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fadGlEPTB;M{SuNVAxPiEQvF2= MXLTRW5ITVJ?
SKM-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LSR2lEPTB;M{euPFQzOiEQvF2= NUjWVFB7W0GQR1XS
NCI-H1838 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{SyfGlEPTB;M{iuN|c6PyEQvF2= M{TDUXNCVkeHUh?=
RL NXLjS5BFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLDc3BKSzVyPUO5MlI1PzdizszN NYW4fZI3W0GQR1XS
COLO-800 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTRyLkC3O|Mh|ryP NXjaPIpvW0GQR1XS
KG-1 NXrnOmQ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXqV3BIUUN3ME20NE45QTV3IN88US=> MVfTRW5ITVJ?
TUR MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HzW2lEPTB;NEGuOlM6QSEQvF2= M1Lob3NCVkeHUh?=
LNCaP-Clone-FGC NF:xO4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIGz[JBKSzVyPUSxMlkxOTdizszN MkW0V2FPT0WU
NCI-H322M M3TLUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn2wTWM2OD12Mj61PVg1KM7:TR?= NVf3dJNSW0GQR1XS
LNCaP  MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTlzLkOgcm0> NIPVO2gzPTVyNUG3OC=>
C4-2 NUDncZp1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfsR3FlUUN3ME24JI5O MnS3NlU2ODVzN{S=
JURKAT NYDX[|RVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlixNlQhcA>? MXrJR|UxRTRzNj62OkBvVQ>? MkjlNlQ2OTl7OUW=
MOLT-4 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV[yOEBp MoXUTWM2OD1{OEWzMlUhdk1? MlO2NlQ2OTl7OUW=
REH NXf3ZppUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV2yOEBp NHXVeZRKSzVyPUK4O{43QCCwTR?= M2jHPFI1PTF7OUm1
NALM-6 NE\rbINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHT[|UzPCCq NUmyeohUUUN3ME2zOFM{OCCwTR?= NYfqPVJSOjR3MUm5PVU>
RS 4;11 NGTk[npIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3EZm5rOjRiaB?= MVjJR|UxRTVzOT6wOUBvVQ>? MoTuNlQ2OTl7OUW=
697 MmLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHj4W5ozPCCq NInDRVVKSzVyPUKxNFcvOSCwTR?= Ml7HNlQ2OTl7OUW=
SIL-ALL NITSRoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUOyOEBp NHPYXZlKSzVyPUG5PU44PyCwTR?= NWi3NJYyOjR3MUm5PVU>
CEM NHjYSpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;LNlQhcA>? MXjJR|UxRTV{LkG4JI5O NIL6WZQzPDVzOUm5OS=>
P12 MneyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3T5RlI1KGh? NELIUnZKSzVyPUO5MlI4KG6P MljHNlQ2OTl7OUW=
NALM-16 MlrsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU[yOEBp M335[WlEPTB;OU[uNlghdk1? MnjlNlQ2OTl7OUW=
JURKAT MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWD3eXpNPDhiaB?= MVvJR|UxRTF2Lki0JI5O MnnDNlQ2OTl7OUW=
MOLT-4 NHjIOpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE[xXWE1QCCq NXXEWopTUUN3ME2yOk43KG6P NWPVeI5COjR3MUm5PVU>
REH Mon4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\wTm93PDhiaB?= M1\5fWlEPTB;NESuO|Ehdk1? NEnv[o8zPDVzOUm5OS=>
NALM-6 NXziVJFST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPKOFghcA>? Moj5TWM2OD1{Mz6yOkBvVQ>? NVPkbHlXOjR3MUm5PVU>
RS 4;11 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjCPHRsPDhiaB?= M1fHT2lEPTB;MU[0MlI5KG6P MUSyOFUyQTl7NR?=
697 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPUc|g1QCCq Ml:5TWM2OD1|MEWuN{BvVQ>? MnzpNlQ2OTl7OUW=
SIL-ALL NWjKeIFET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYS0PEBp NE\oR2NKSzVyPUe0MlYzKG6P NXnlVWx7OjR3MUm5PVU>
CEM NHnuNotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLwelQ1QCCq NWjJZ5hEUUN3ME2yOE42PSCwTR?= MXGyOFUyQTl7NR?=
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NALM-16 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;wepE1QCCq M3X2V2lEPTB;NkOuNlQhdk1? NXfqcVZ6OjR3MUm5PVU>
JURKAT NVPLN2RRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjIO|IhcA>? M3TsWmlEPTB;Mz62OUBvVQ>? M3v5cVI1PTF7OUm1
MOLT-4 NXrMZmV7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnaO|IhcA>? NF\ZZmFKSzVyPUeuN|khdk1? NYDTTW9DOjR3MUm5PVU>
REH NUnzT4h1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vt[VczKGh? MnzyTWM2OD1zNj6wNUBvVQ>? MkLJNlQ2OTl7OUW=
NALM-6 NH;TNFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfyRWg4PzJiaB?= M3LlcWlEPTB;MT63PEBvVQ>? NI\pSmQzPDVzOUm5OS=>
RS 4;11 Mlf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrjO|IhcA>? NGmyVnlKSzVyPUSuN|ghdk1? NHrON|EzPDVzOUm5OS=>
697 MlrTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHxOlA4OiCq M1qxdWlEPTB;N{SuNlghdk1? MoTENlQ2OTl7OUW=
SIL-ALL NHL0cXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofXO|IhcA>? Mn\jTWM2OD15LkKgcm0> M1vOS|I1PTF7OUm1
CEM MnPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWO3NkBp MXrJR|UxRTVwNEKgcm0> NEPzSJozPDVzOUm5OS=>
P12 MnrBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;IXJQ4OiCq MVvJR|UxRTZwM{egcm0> NXHlOVh7OjR3MUm5PVU>
NALM-16 NULFOYl{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTNW5A4OiCq NX\3V2xnUUN3ME23O{44OyCwTR?= MXKyOFUyQTl7NR?=
Y79 M1zJ[GFxd3C2b4Ppd{BCe3OjeR?= NUnwVVI2OS13MDDuUS=> NH\X[pkyOi9{NDDo NVXtT|hTTE2VTx?= MVrpcoR2[2WmIHHwc5B1d3OrczD3bIlkcCClYX6gZoUh\W6qYX7j[YQh[nliSGS= M2rGOFI1OzZ4Nk[1
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G7 M1jINWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmD6TWM2OD1|LkOgcm0> NEPvdHczPDJyNEezNy=>
G166 NFn1NGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXC[3VKSzVyPUeuNEBvVQ>? MmG2NlQzODR5M{O=
CB660 M1XOSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTZwNDDuUS=> NEXoOFkzPDJyNEezNy=>
CB1117 NFfmVVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXr1dlBlUUN3ME2xOU43KG6P M3jY[|I1OjB2N{Oz
KB-3-1 MnzFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTFwNEigxtEhOC53MzDuUS=> NIn6eoIzOzl4MkS0OS=>
KB-8-5-11 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPYRpZKSzVyPUWuNFEhyrFiMj6wNUBvVQ>? NHH5TVIzOzl4MkS0OS=>
KB-C-1 NVOwSJJXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULIfI1WUUN3ME2xOk44PiEEsTC0MlUyKG6P NXXoR5BvOjN7NkK0OFU>
KB-V-1 NYLLW4h[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLuclMxUUN3ME2yPFEvOjRiwsGgN|EvPTdibl2= NFGxPZYzOzl4MkS0OS=>
OVCAR-8 M37MRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1G0VGlEPTB;Nz6xPUDDuSB|Lk[wJI5O M{DYV|I{QTZ{NES1
NCI-ADR-RES M4rhNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHpTWM2OD1zMkezMlMxKMLzIEG5NU4zOCCwTR?= MonwNlM6PjJ2NEW=
MCF7 NHLweYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTVwMUGgxtEhOS52NzDuUS=> NHzZZXYzOzl4MkS0OS=>
MCF7-FLV1000 NESwNG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTN7Mz6xPEDDuSB5ND64N{BvVQ>? M4TEOlI{QTZ{NES1
S1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLSc|VKSzVyPUK0MlMxKMLzIESuO|Uhdk1? M3jKSVI{QTZ{NES1
S1-M1-80 NWj5OIU1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTJ4MT6wOkDDuSB2OD6yOUBvVQ>? MoOxNlM6PjJ2NEW=
CORL-23/P M1nNcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HZWmlEPTB;ND6zPEDDuSBzLkK1JI5O MljQNlM6PjJ2NEW=
CORL-23/R NYfzXHlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTVwMU[gxtEhOS56MzDuUS=> NXzYOXF5OjN7NkK0OFU>
NIH3T3 M2n5cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPtTWM2OD12MD62NEDDuSB2Lkm3JI5O MnvwNlM6PjJ2NEW=
NIH3T3-G185 M{HafWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTJ2MUOuOFAhyrFiNEKzMlY3KG6P MmDLNlM6PjJ2NEW=
pcDNA-HEK293 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnycVFKSzVyPUKuO|UhyrFiMD62O{BvVQ>? Mn3GNlM6PjJ2NEW=
MDR19-HEK293 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXvTWM2OD16NT61NEDDuSBzMz62O{BvVQ>? NVG0OFNpOjN7NkK0OFU>
R482-HEK293 M3;PeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;STWM2OD1{NT65O{DDuSB2Lkm1JI5O NF\WUW8zOzl4MkS0OS=>
MRP1-HEK293 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml34TWM2OD1{Lkm5JOKyKDFwNEmgcm0> M{fmWVI{QTZ{NES1
SF188 NEjRUGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVqxNE0yODBibl2= NY\ie2F[OjRvOU[gbC=> NVS3[G81TE2VTx?= NV3GcYxQcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZo91cCC2aX3lMUBidmRiY3;uZ4VvfHKjdHnvck0h\GWyZXTlcpQhdWGwbnXy M1n1W|I{QDh5NkS1
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DU145 NXnGS2NkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;YSG1UVw>? NYXkVVB[UUN3MPMIwFYxKG6P NIHocXIzOzh6NESyPC=>
LNCaP  NXT6e5ZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\URmROW09? MmLITWM2OOLKvEe1JI5O NYnJW|lTOjN6OES0Nlg>
PC3 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jNRWROW09? Mo\KTWM2OOLKvEG3OUBvVQ>? Ml;NNlM5QDR2Mki=
RT4 NX;6NGNbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTDTWM2OD1{Nz6yNUBvVQ>? MWiyN|c6OjZ|OR?=
5637 NWXqWnpET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnVVG9KSzVyPUS1MlQ4KG6P MXmyN|c6OjZ|OR?=
T24 Mnr5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoGzTWM2OD15OT6xNkBvVQ>? NXPZOpNEOjN5OUK2N|k>
MCF7  NHjBOmFHfW6ldHnvckBCe3OjeR?= NUfSVW5ZOTByIH7N NIfofoIyKGh? NGXWPHFFVVOR NFXDW4Zz\WS3Y3XzJJRp\SCrbnT1Z5Rqd25ib3dCpGdz\WJzLNMgV4dsOS{EoGDzNkzDqFOncoDpcoE{NCCjbnVCpHdqe3B{ NUP6eGF{OjN5N{CyOFQ>
KB-V1  MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHCNItXUUN3ME2zMlkzKM7:TR?= NVn0fXI2OjN3OUOxPVY>
Hec50co NHrGbWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTVibl2= MoXYNlMyPDZ4OEe=
MDA-MB-468 NYHSNVB{SXCxcITvd4l{KEG|c3H5 MX[xM|UwOTBibl2= MYOyOE81QC95MjDo NHvCb4xFVVOR MYPpcoR2[2W|IHHwc5B1d3OrczDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= NUPNWZpqOjNzNESyPVQ>
MCF10A NWj5NXo4SXCxcITvd4l{KEG|c3H5 MVixM|UwOTBibl2= NYPQbZVOOjRxNEivO|IhcA>? M13ZT2ROW09? NWrBeJI3cW6mdXPld{BieG:ydH;zbZMhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> NEXoSFgzOzF2NEK5OC=>
Huh-7 Ml7ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHlNocyNzFyL{GwNE8yODByIH7N NFjrN3g1QCCq MVzk[YNz\WG|ZYOgeIhmKGOnbHygeoli[mmuaYT5JIRwe2VvZHXw[Y5l\W62bIm= Mn\sNlI4PDV3OEe=
Daoy  MlriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTQSVgyNjh5NT2yOFAhdk1? NIewOIM4OiCq MnzrSG1UVw>? NX:4SZhNUUN3ME21JI5O NGHQ[JMzOjN7MEK3PS=>
ONS-76 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVOxMlg4PS1{NECgcm0> NHrKR4s4OiCq MoLTSG1UVw>? M1OwfmlEPTB;Nz61JI5O M4rM[VIzOzlyMke5
SUM 149 M{LsV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXOwMVExOCCwTR?= MVq3NkBp MY\pcohq[mm2czD0bIUh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wYYK= M4\m[lIzOzB7OUO5
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BT-474-M1 MmDGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXOwMVExOCCwTR?= M1;iW|czKGh? Mo\UbY5pcWKrdIOgeIhmKGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnHy NVHuN5ZjOjJ|MEm5N|k>
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ACHN NHflbJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37Zd|UuQDBibl2= M2LlZVk3KGh? M1TZUGhEdA>? NFznfGp{fXCycnXzd4V{KHSqZTDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVzKHerdHigTWM2OMLidnHseYV{KG:oIEKgeI8hOjBibl2= M{LXSFIyPjR{M{e0
Caki-1 M1vp[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPRcos5PS16MDDuUS=> M{DDW|k3KGh? MlzmTGNt NIPqTHp{fXCycnXzd4V{KHSqZTDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVzKHerdHigTWM2OMLidnHseYV{KG:oIEKgeI8hOjBibl2= NUPpZVRsOjF4NEKzO|Q>
SN12C NF\KdVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPKOU05OCCwTR?= NFi4VHQ6PiCq MXvIR4w> MnP2d5VxeHKnc4Pld{B1cGVicILvcIln\XKjdHnvckBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldkB4cXSqIFnDOVDDqH[jbIXld{Bw\iB{IITvJFIxKG6P MnrRNlE3PDJ|N{S=
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HMC-1.2 NFXLOIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvBPG43OS1zMECwJI5O M3Wwc|czKGh? M4G5RolvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\Q>? NHLFWW8zOTJ2MkG4PS=>
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CAL62 MoT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnY[ogxNjFvMUCwJI5O NFHleJA4OiCq NGLrb2tFVVOR NF7HOWNGSzVyPUGuOEBvVQ>? NF;Pc5kyQTJ{M{W1Ny=>
OCUT-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYiwMlEuOTByIH7N MlroO|IhcA>? M13xOGROW09? MXLFR|UxRTJwMzDuUS=> MVSxPVIzOzV3Mx?=
8505C M2S0d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4X0XVAvOS1zMECgcm0> NXO2UVlrPzJiaB?= NGHLTI9FVVOR MV3FR|UxRTNwMjDuUS=> MlLxNVkzOjN3NUO=
ACT-1 NImwWVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7hbopUOC5zLUGwNEBvVQ>? MlXCO|IhcA>? MXvEUXNQ NWnYdXRTTUN3ME21MlQhdk1? MWSxPVIzOzV3Mx?=
SW1736 NH7BWnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV6wMlEuOTByIH7N MUG3NkBp NU\aPGN2TE2VTx?= NVTLTmZ1TUN3ME21MlYhdk1? M4XxNlE6OjJ|NUWz

... Click to View More Cell Line Experimental Data

体内研究 BI 2536静脉注射给药多种移植瘤模型,每周一次或两次,效果都很好,通过使细胞周期停滞而抑制细胞增殖,随后诱导肿瘤细胞死亡。BI 2536按 50 mg/kg剂量处理HCT 116移植瘤,每周一次或两次,显著抑制肿瘤生长,T/C 分别为15%和0.3%。BI 2536每周处理两次BxPC-3和A549模型,也显著抑制肿瘤生长,T/C分别为5% 和14%。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验: [1]
+ 展开

体外Plk1激酶实验:

重组人Plk1 (1-603残基) 作为氮端,携带杆状病毒表达系统的GST-标记的融合蛋白通过亲和层析,使用谷胱甘肽-琼脂糖而纯化。在梯度稀释的BI 2536存在时,使用 20 ng 重组激酶,及10 μg牛奶中的酪蛋白作为底物进行Plk1 酶活性实验。在终体积为60 μL 的混合物(15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP)中30oC下进行激酶反应45分钟。加入 125 μL 冰冻的5% TCA终止反应。沉淀物转移到混合酯纤维素的多屏过滤板上,使用1% TCA冲洗实验板,然后利用放射性进行测量。绘制剂量反应曲线,而计算IC50值。
细胞实验:[1]
+ 展开
  • Cell lines: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji, PC-3,等等
  • Concentrations: 溶于DMSO, 终浓度为~1 μM
  • Incubation Time: 24,和72小时
  • Method: 使用不同浓度BI 2536处理细胞24和72小时。 在荧光分光光度计中测量Alamar Blue染料转换而测定细胞生长。为了测定培养基中DNA含量,细胞悬液在80%乙醇中混合, 使用溶于PBS的0.25% Triton X-100处理5分钟,然后与0.1% RNase 和溶于PBS的 10 μg/mL碘化丙啶在室温下温育20分钟。通过流式细胞仪分析而测定细胞周期谱。
    (Only for Reference)
动物实验:[1]
+ 展开
  • Animal Models: 皮下注射HCT 116, NCI-H460, 或A549 细胞的雌性BomTac:NMRI-Foxn1nu 小鼠
  • Formulation: 在盐酸(0.1 N)中配制,然后在0.9% NaCl中稀释。
  • Dosages: ~50 mg/kg
  • Administration: 静脉注射,每周一到两次
    (Only for Reference)

溶解度 (25°C)

体外 Ethanol 100 mg/mL (191.69 mM)
DMSO 21 mg/mL (40.25 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
30% PEG 400+0.5% Tween 80+5% Propylene glycol
15mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 521.66
化学式

C28H39N7O3

CAS号 755038-02-9
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00526149 Completed Breast Cancer|Endometrial Cancer|Head and Neck Cancer|Melanoma (Skin)|Ovarian Cancer|Sarcoma European Organisation for Research and Treatment of Cancer - EORTC July 2007 Phase 2
NCT00526149 Completed Breast Cancer|Endometrial Cancer|Head and Neck Cancer|Melanoma (Skin)|Ovarian Cancer|Sarcoma European Organisation for Research and Treatment of Cancer - EORTC July 2007 Phase 2
NCT02215044 Terminated Pancreatic Neoplasms Boehringer Ingelheim June 2007 Phase 1
NCT02215044 Terminated Pancreatic Neoplasms Boehringer Ingelheim June 2007 Phase 1
NCT00412880 Completed Carcinoma Small Cell Boehringer Ingelheim January 2007 Phase 2
NCT00412880 Completed Carcinoma Small Cell Boehringer Ingelheim January 2007 Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?

  • 回答:

    For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

PLK Signaling Pathway Map

PLK Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID