BI 2536

For research use only. Not for use in humans.

目录号：S1109

CAS No. 755038-02-9

BI-2536是一种有效的Plk1抑制剂，无细胞试验中IC50为0.83 nM。BI-2536可抑制 Bromodomain 4 (BRD4) ，其Kd值为37 nM，并有效地抑制 c-Myc 的表达。BI-2536可诱导凋亡而减弱自噬。Phase 2。

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10mM (1mL in DMSO)	RMB 1978.87	现货
5mg	RMB 981.57	现货
10mg	RMB 1704.35	现货
50mg	RMB 5492.59	现货
100mg	RMB 8160.83	现货
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客户使用Selleck生产的BI 2536发表文献209篇：

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产品安全说明书

PLK抑制剂选择性比较

生物活性

产品描述

特性

BI 2536是第一个有效的Plk1选择性抑制剂，抑制 Plk1的标记。

靶点

c-Myc ^[3] ()	PLK1 ^[1] (Cell-free assay)	PLK2 ^[1] (Cell-free assay)	PLK3 ^[1] (Cell-free assay)	BRD4 ^[3] (Cell-free assay)
	0.83 nM	3.5 nM	9.0 nM	37 nM(Kd)

体外研究

除了Plk1, BI 2536也抑制 Plk2 和Plk3活性，只是抑制程度低点,IC50分别为3.5 nM和9.0 nM。BI 2536比一组63种其他蛋白激酶（IC50>10 μM）选择性高1000多倍。BI 2536 按10 nM 到 100 nM剂量作用于HeLa细胞，抑制有丝分裂中心体中γ-微管蛋白招募和Apc6 磷酸化，抑制染色体臂中释放黏结蛋白, 诱导产生单极主轴，及一些依赖Plk1的其他有丝分裂过程。与作用于Plk1 RNAi效果相一致, BI 2536处理HeLa细胞，使细胞周期停在G2/M期, 随后DNA分解及凋亡，且累积断裂的PARP p85片段，这种作用存在浓度依赖性。BI 2536抑制一组32种人肿瘤细胞系生长，EC50为2-25 nM,抑制指数生长的hTERT-RPE1,人脐静脉内皮细胞 (HUVECs),和正常大鼠肾脏(NRK) 细胞的增殖，EC50为12-31 nM。^[1] BI 2536 抑制Plk1，降低甲状腺未分化癌(ATC)细胞如 CAL62, OCUT-1, SW1736, 8505C,和 ACT-1 的生长的生长和活力，EC50为1.4-5.6 nM。^[2]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
PSN1	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3nieGlEPTB;MD6wNFc4PiEQvF2=	NGrXSIM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
ACN	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NVfaTHpmUUN3ME2wMlAxQDR\|IN88US=>	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
TE-8	NX7CZ2xIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NIPsPVRKSzVyPUCuNFA6PDFizszN	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
LC-2-ad	NWLrWFJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MYjJR\|UxRTBwMEGwPVMh\|ryP	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
ALL-PO	MmPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3HLdWlEPTB;MD6wNVMh\|ryP	NFXG[Ik9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
EW-16	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnjwTWM2OD1yLkCxN\|M3KM7:TR?=	NGi0UVA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
KM12	NFn4SIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NV3L[VdFUUN3ME2wMlAyOzR6IN88US=>	NIq2SXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
GI-1	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NVPQOHV6UUN3ME2wMlAyOzh\|IN88US=>	NF\kUFg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
LS-411N	NFfNdHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NH;uc4lKSzVyPUCuNFE1ODdizszN	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
ES8	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFPlUJhKSzVyPUCuNFE1QTRizszN	M3vRV\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
SNU-C2B	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{Di[2lEPTB;MD6wNVUzPiEQvF2=	MnTuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
CESS	NHjLWpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NGLzV\|ZKSzVyPUCuNFE3ODJizszN	NVz0THllRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
697	NG[1NnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MmSyTWM2OD1yLkCxOlY5KM7:TR?=	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
NCI-H1963	MoXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Ml\LTWM2OD1yLkCxOlc{KM7:TR?=	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
IA-LM	NWHiO3pNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1LRRmlEPTB;MD6wNVY5QCEQvF2=	MnrjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
SW954	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NVS1RnpjUUN3ME2wMlAyPzB3IN88US=>	NEXoc4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
RL95-2	M2fzWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NYPp[ZlyUUN3ME2wMlAyPzN6IN88US=>	MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
LXF-289	NGXSSZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MX7JR\|UxRTBwMEG3O{DPxE1?	M4HUSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
OCUB-M	NYPCNYpsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MUfJR\|UxRTBwMEG4NlYh\|ryP	MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
RKO	M3Hjfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NXjnTJR{UUN3ME2wMlAyQTh5IN88US=>	M1nse\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
LOUCY	NXLOeGl5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NWXie3QyUUN3ME2wMlAzODVizszN	NG\IS\|E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NOS-1	MofMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NIrWcGZKSzVyPUCuNFIxQTNizszN	MlTJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
A4-Fuk	M1yyfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFe4TI9KSzVyPUCuNFIzOThizszN	M1PqeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
A388	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{[1fmlEPTB;MD6wNlIzPyEQvF2=	NGfpemc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
TE-9	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnzMTWM2OD1yLkCyNlYyKM7:TR?=	MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
KURAMOCHI	M1LCOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NGT3fYVKSzVyPUCuNFIzQDVizszN	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
KALS-1	NI\QNIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NYPHdGN5UUN3ME2wMlAzOzN6IN88US=>	MmrzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
HOP-62	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NI\0T2ZKSzVyPUCuNFI1OiEQvF2=	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
RPMI-8402	NX;5ZmJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NWnBVZAxUUN3ME2wMlAzPTB6IN88US=>	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
TE-1	MmjmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M4ToRmlEPTB;MD6wNlUyOiEQvF2=	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
CCRF-CEM	NIC1U5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MV3JR\|UxRTBwMEK1OFMh\|ryP	M3nUb\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
HUTU-80	MofaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYK2PZlyUUN3ME2wMlAzPjJ2IN88US=>	NF7qW3U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NCI-H1648	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MWDJR\|UxRTBwMEK2OFch\|ryP	Mm\DQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
HCE-4	M4L2PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MorvTWM2OD1yLkCyOlgzKM7:TR?=	MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
ETK-1	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnG4TWM2OD1yLkCyO\|M3KM7:TR?=	MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
TE-15	MnPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYHJR\|UxRTBwMEK3N\|gh\|ryP	M2[1TlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
BE-13	NFT6NGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NYHyV3QzUUN3ME2wMlAzPzRizszN	NGrLXnQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
KE-37	M2ixW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M17leWlEPTB;MD6wNlc1OSEQvF2=	NXjzNpIzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NCI-H1355	NID4cmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MV7JR\|UxRTBwMEK3PFMh\|ryP	NV25VmRRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
TE-11	NEHxdpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVrheoFUUUN3ME2wMlAzQDB7IN88US=>	MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
BL-70	NWHHTI9CT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1;wWGlEPTB;MD6wNlg2PyEQvF2=	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
ES6	M3HlWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NF;PWlBKSzVyPUCuNFI5QDFizszN	NFvQT4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
GT3TKB	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3u3ZmlEPTB;MD6wNlk2OyEQvF2=	MmO4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
LB647-SCLC	NHjRXFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVXJR\|UxRTBwMEOxPVUh\|ryP	Mo\LQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NB13	Mlm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1W4SWlEPTB;MD6wN\|MyPiEQvF2=	NHPwdXA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
ST486	MnO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MoXtTWM2OD1yLkCzN\|M4KM7:TR?=	MnnUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NCI-H82	NHzpSmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NIm2OlNKSzVyPUCuNFM{PDNizszN	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
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LAMA-84	M2jaPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1\pcWlEPTB;MD6xN\|E5PyEQvF2=	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
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KP-N-RT-BM-1	NVr5ZXVST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHPLbGRKSzVyPUCuNVM3OTJizszN	NV63Olk4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
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LP-1	NXW4fHR7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NV;oTGdlUUN3ME2wMlE1OjRizszN	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
CAL-148	MonvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mn7BTWM2OD1yLkG0OFg{KM7:TR?=	NUjEOlhrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
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COLO-684	MkiwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHjrPJJKSzVyPUCuNVU4OjFizszN	NH7nU3o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
KINGS-1	NHSwXGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NIHW[29KSzVyPUCuNVU6OSEQvF2=	Mm\tQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
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NCI-H64	M2G0T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4LOOGlEPTB;MD6xOlM1PyEQvF2=	Ml\VQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
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SCC-3	NWLtTIwzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M4i0fGlEPTB;MD61NVg4OyEQvF2=	Mmq5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
KLE	M2jIT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MmTITWM2OD1yLkWyNVcyKM7:TR?=	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
LB2241-RCC	NUSxeZNxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mk[zTWM2OD1yLkWyOVI2KM7:TR?=	NVz6c4JURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NCI-H1417	Mni1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MXPJR\|UxRTBwNUO0N\|Uh\|ryP	MoGxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NCI-H2081	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NV:3VldWUUN3ME2wMlU5PjFzIN88US=>	MkL4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NCI-H1522	MnrNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlHKTWM2OD1yLkW5N\|g{KM7:TR?=	MnXJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NCI-H889	NHXuOFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MnvGTWM2OD1yLkW5PFQ1KM7:TR?=	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
CGTH-W-1	NH:1OVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXzJR\|UxRTBwNkC3OVUh\|ryP	NHW5Npc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
EB-3	NHPCTolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NHHsOHpKSzVyPUCuOlEyPTNizszN	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
D-336MG	NInHVnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVTJR\|UxRTBwNkG3PVEh\|ryP	NVzscnE1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
LC-1F	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NYrpNY5jUUN3ME2wMlYzPTl{IN88US=>	NH[wdHg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
MHH-NB-11	MoDZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M4Oyc2lEPTB;MD62N\|gxOSEQvF2=	MkW2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
SK-N-FI	M2fmc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NULMXoQ6UUN3ME2wMlY{QTFizszN	NULyTJRFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NCI-H69	NFrFdnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MlXqTWM2OD1yLk[0PFc6KM7:TR?=	MlP4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
SCH	M4TXVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NXraWXZvUUN3ME2wMlY3ODJ\|IN88US=>	M3L3PVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
LS-513	NUSxVphoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NIP6UZlKSzVyPUCuOlczPTlizszN	MkDwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
CP67-MEL	Mn;2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFq5Z5JKSzVyPUCuOlc2QTZizszN	MlfHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
GCIY	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2OxUWlEPTB;MD63NFM3OyEQvF2=	Mof1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
SHP-77	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlXxTWM2OD1yLkewO\|M1KM7:TR?=	M3LQUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
EHEB	Mn\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NWTuOJZlUUN3ME2wMlcyQDV2IN88US=>	NX;uSVJ6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
D-247MG	NEnRd2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUTXW3plUUN3ME2wMlc{OjN{IN88US=>	NVrtN\|h4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
Raji	NFniTppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NIC0N3FKSzVyPUCuO\|Q6QDlizszN	MorlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
MPP-89	NW\JeoFJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MWPJR\|UxRTBwN{W5O\|gh\|ryP	MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
EKVX	NF3yPXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M33GPGlEPTB;MD63PVA4OyEQvF2=	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
HCC2218	M336UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4nrb2lEPTB;MD63PVE{OSEQvF2=	M{e0dVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
KNS-81-FD	NXT4VXB5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NVm3PFkzUUN3ME2wMlgyODFzIN88US=>	MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
HCC2157	Mn;OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHPGV4NKSzVyPUCuPFQ6PTFizszN	MnrLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
BT-474	NXjGcnV1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MkjiTWM2OD1yLki4PFU1KM7:TR?=	NYLad4xJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NCI-H748	M2rjSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mk\zTWM2OD1yLkmxNkDPxE1?	MmjRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
EW-24	MmnwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NX64NHhZUUN3ME2wMlkzODB{IN88US=>	NGLuRWg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
D-263MG	M1PwXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NGLDOldKSzVyPUCuPVQ2OTJizszN	NHrFUHg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
OMC-1	M4DlbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4rHSGlEPTB;MD65OlM4OyEQvF2=	MnTRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NCI-H2196	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MonuTWM2OD1yLkm3O\|c4KM7:TR?=	M1rMO\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
HAL-01	NU[2fY9[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NFzNPJlKSzVyPUCuPVk5PzJizszN	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
NCI-H2107	M{PROWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MlXTTWM2OD1zLkCxPFU1KM7:TR?=	NVfKN2RYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
LB996-RCC	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlXOTWM2OD1zLkC4NFUyKM7:TR?=	NVn1ZYt7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NCI-H1395	M2TQSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MV;JR\|UxRTFwMUC2O{DPxE1?	NGrZ[2k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
CHP-126	MmHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVfhOlEyUUN3ME2xMlE3OTl7IN88US=>	M{HK[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
NB69	NEPLXGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2G5T2lEPTB;MT6yOlE1QCEQvF2=	Mn25QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
CAS-1	MoX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYjJR\|UxRTFwM{SyN\|Eh\|ryP	NX6zNYt6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
JVM-3	M2rSOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2XHVWlEPTB;MT60O\|g2PSEQvF2=	M1TSSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
DMS-153	NHu3[mZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4TKN2lEPTB;MT61O\|Y4PCEQvF2=	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
SK-MEL-2	MnjjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVm0SIVTUUN3ME2xMlcyPzh7IN88US=>	NVnSdnZkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NCI-H1155	NXLvOI9VT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MonrTWM2OD1zLkezOlc3KM7:TR?=	M1nh[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
NCI-H1092	MmHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MnrFTWM2OD1zLke2NVgzKM7:TR?=	Mnr5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
LU-165	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVXJR\|UxRTFwOE[0O\|Yh\|ryP	NF3t[3o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
HL-60	M{\5O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MmLkTWM2OD1zLkm5PVA5KM7:TR?=	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
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NCI-H2171	MlyyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVjJR\|UxRTNwMEO0OFgh\|ryP	NWjpO2Y5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
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SIMA	M3e0e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M3izb2lEPTB;Mz61PFQyPiEQvF2=	MnW2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
SW872	M1;CVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M3ToTWlEPTB;Mz63PFExOSEQvF2=	NXHsTI41RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
HCC1187	M{C2NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVjJR\|UxRTNwN{izNVUh\|ryP	NEH4UoY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
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NCI-SNU-1	NUjOWJhLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Ml[xTWM2OD12LkKxPVk6KM7:TR?=	M1PFOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
NCI-H226	NUe1OpF2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NFXxc5pKSzVyPUSuN\|M3ODZizszN	NXn5U\|hFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
RPMI-8866	NUX0d216T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M4npfWlEPTB;ND6zOlAzQSEQvF2=	MljuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
OCI-AML2	M17XPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4X1e2lEPTB;ND61OVI{KM7:TR?=	M2\veFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
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SK-N-DZ	Ml;vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NWH4dFhyUUN3ME21MlY{PDZ3IN88US=>	MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
NB14	NHm0OWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWXDTmtLUUN3ME21Mlk4OTN3IN88US=>	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
COLO-829	NYmwTlV4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXTqPVc4UUN3ME22MlM{OzV7IN88US=>	NV7Qe5BMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
MHH-CALL-2	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M37mZmlEPTB;Nj61NVUxQCEQvF2=	M3jUPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
NCI-H1770	NXPV[3dsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MWjJR\|UxRTZwNk[5NFQh\|ryP	NFHJN249[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
ECC4	NWTBfW5VT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXexelIzUUN3ME22MlgzOTd7IN88US=>	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
A498	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFv1XJhKSzVyPU[uPFcyQTJizszN	M1W2N\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
DMS-79	M1j3VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Ml7ETWM2OD15LkC0OVEzKM7:TR?=	M4mxVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
P30-OHK	M4SxOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NIPNeItKSzVyPUeuNlE6ODZizszN	MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
D-502MG	MkHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFfafI1KSzVyPUeuPVg{PiEQvF2=	NETkSow9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
RCC10RGB	NYrJO5NKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NWDtWWdnUUN3ME24MlA3OjhizszN	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
U-698-M	NY\oXZFiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M4XkUmlEPTB;OD6yPVIzPiEQvF2=	M2\5TVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
BB49-HNC	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NXTFcI1GUUN3ME25MlQzOjZ3IN88US=>	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
ES1	M1vSfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXnJR\|UxRTlwNki5OVYh\|ryP	NFLyWVA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
MFM-223	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NEPobIRKSzVyPUGwMlk6OjdizszN	Ml;YQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
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EB2	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NUf6[ZFSUUN3ME2xNk43QDhzIN88US=>	MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
C8166	NHfkXVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MkfHTWM2OD1zMz64N\|A{KM7:TR?=	M1\ZNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
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NCI-H1650	M3L6UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NUf6XXZ7UUN3ME2xOk4{PzZ3IN88US=>	M1LNV\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
Mo-T	M1fKWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MnftTWM2OD1zNz60NFI6KM7:TR?=	NIPzd2Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NB7	NHrZOnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3nTOWlEPTB;MUeuO\|Q3PyEQvF2=	NGnIUI09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
ES7	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MoXTTWM2OD1zOT61OVA4KM7:TR?=	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
ES5	MnrES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVzV[lJwUUN3ME2yNU44PjdzIN88US=>	NF3ONXg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
MSTO-211H	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NUHGT2h7UUN3ME2yNU45QDV6IN88US=>	M1PR[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
U-87-MG	MmD1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHG0XFdKSzVyPUK1MlE6PjZizszN	M{XPdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
THP-1	NXO4XGhNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mle1TWM2OD1{OT63NlAyKM7:TR?=	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
NB10	NXfOSm5lT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MVTJR\|UxRTNyLkK2PVQh\|ryP	MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
NH-12	MmnZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYrJR\|UxRTN\|LkKwNVch\|ryP	MkD4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
COLO-824	M1XhWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NEGyfWlKSzVyPUO0MlExODZizszN	M{i2UlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
SKM-1	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MXHJR\|UxRTN5Lki0NlIh\|ryP	NXLrR2R{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NCI-H1838	NX;ZfpdqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NVjX[INPUUN3ME2zPE4{Pzl5IN88US=>	NGi4W289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
RL	MmfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYPJR\|UxRTN7LkK0O\|ch\|ryP	MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
COLO-800	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NUTkRolPUUN3ME20NE4xPzd\|IN88US=>	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
KG-1	MmDyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3ewWmlEPTB;NECuPFk2PSEQvF2=	NFjVfYc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
TUR	M4LaXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NE\PRVdKSzVyPUSxMlY{QTlizszN	MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
LNCaP-Clone-FGC	M{DhNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MU\JR\|UxRTRzLkmwNVch\|ryP	NEnISHM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NCI-H322M	NGm0fZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NHHuZlFKSzVyPUSyMlU6QDRizszN	NYS0b\|ZRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
LNCaP	NWrQTllkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUm4NZRqUUN3ME25NU4{KG6P	NILnUow9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUWwOVE4PCd-MkW1NFUyPzR:L3G+
C4-2	NILwVplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVLJR\|UxRThibl2=	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTVyNUG3OEc,OjV3MEWxO\|Q9N2F-
JURKAT	MmnsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NWXUdo9QOjRiaB?=		M322fWlEPTB;NEG2MlY3KG6P	MlHzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
MOLT-4	NHX6SHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NU\zS2tqOjRiaB?=		M4TXT2lEPTB;Mki1N{42KG6P	MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
REH	MoTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		Mof6NlQhcA>?		M1;idmlEPTB;Mki3MlY5KG6P	Ml7QQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
NALM-6	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MXmyOEBp		NWrwTmJZUUN3ME2zOFM{OCCwTR?=	NIXLenc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
RS 4;11	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NXrKXotkOjRiaB?=		MUjJR\|UxRTVzOT6wOUBvVQ>?	NE\KfJQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
697	NETFVZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NXPrZ2g{OjRiaB?=		NV7qdZBkUUN3ME2yNVA4NjFibl2=	MoTPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
SIL-ALL	NY\WOVBmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MYqyOEBp		MYLJR\|UxRTF7OT63O{BvVQ>?	NWnQNGZHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NVk6QTVpPkK0OVE6QTl3PD;hQi=>
CEM	M4rwZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NEn2elQzPCCq		MX;JR\|UxRTV{LkG4JI5O	MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
P12	NEDzT2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		M3GxRlI1KGh?		MULJR\|UxRTN7LkK3JI5O	NH;SUJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
NALM-16	NU\0WId7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MW[yOEBp		MYrJR\|UxRTl4LkK4JI5O	MlrzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
JURKAT	M{i5b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MoPhOFghcA>?		M4q4eGlEPTB;MUSuPFQhdk1?	MkjrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
MOLT-4	Mo\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NVLycZNVPDhiaB?=		NEe0eJVKSzVyPUK2MlYhdk1?	M3jReFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
REH	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NIXxeGw1QCCq		MmHGTWM2OD12ND63NUBvVQ>?	MnvrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
NALM-6	M4\0[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NVzFOoo3PDhiaB?=		Mly3TWM2OD1{Mz6yOkBvVQ>?	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
RS 4;11	M3fTUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NYnS[YdrPDhiaB?=		NXHQN4FuUUN3ME2xOlQvOjhibl2=	NXPhUHZiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NVk6QTVpPkK0OVE6QTl3PD;hQi=>
697	M3juWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MnT0OFghcA>?		MUjJR\|UxRTNyNT6zJI5O	M3\SNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
SIL-ALL	MkP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		M{HVWlQ5KGh?		NIXRSGdKSzVyPUe0MlYzKG6P	M{TwN\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
CEM	MkK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MWW0PEBp		NF60fpdKSzVyPUK0MlU2KG6P	M4XOeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
P12	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		Mn:1OFghcA>?		MXvJR\|UxRTF6LkS2JI5O	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
NALM-16	M4fTRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MYi0PEBp		M2jTbGlEPTB;NkOuNlQhdk1?	M1SzTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
JURKAT	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NVezPJpKPzJiaB?=		NXfoO2JSUUN3ME2zMlY2KG6P	MnnMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
MOLT-4	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NHvB[YM4OiCq		MmnpTWM2OD15LkO5JI5O	NX3zfWk4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NVk6QTVpPkK0OVE6QTl3PD;hQi=>
REH	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NInVWoY4OiCq		M2LRRWlEPTB;MU[uNFEhdk1?	NH7LcmQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
NALM-6	NYjRUotsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MWS3NkBp		NU\rZmJsUUN3ME2xMlc5KG6P	MorOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
RS 4;11	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NGTWToE4OiCq		MUPJR\|UxRTRwM{igcm0>	Mn2xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
697	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NHnuOW04OiCq		Mn;MTWM2OD15ND6yPEBvVQ>?	M2q0b\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
SIL-ALL	NUPkRoRMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MVu3NkBp		MYnJR\|UxRTdwMjDuUS=>	NV61VoI6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NVk6QTVpPkK0OVE6QTl3PD;hQi=>
CEM	NX;QOFdpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MoDJO\|IhcA>?		M1XrR2lEPTB;NT60NkBvVQ>?	MnX5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
P12	NGmzc\|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NYHJ[2l{PzJiaB?=		NVGxdHF3UUN3ME22MlM4KG6P	M{LHUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
NALM-16	NXXSN5JzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NEi2[pQ4OiCq		NWDMUJRRUUN3ME23O{44OyCwTR?=	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
Y79	NX7ZRpBQSXCxcITvd4l{KEG\|c3H5	M3zGPFEuPTBibl2=	MVexNk8zPCCq	NEjGXZZFVVOR	NGP2TJdqdmS3Y3XkJIFxd3C2b4Ppd{B4cGmlaDDjZY4h[mViZX7oZY5k\WRiYomgTHQ>	M2j0UFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{[2OlY2Lz5{NEO2OlY3PTxxYU6=
WER-Rb-1	MmLLRZBweHSxc3nzJGF{e2G7	M3vPS\|EuPTBibl2=	NVfyb2ZNOTJxMkSgbC=>	MYfEUXNQ	MoXXbY5lfWOnZDDhdI9xfG:\|aYOge4hq[2hiY3HuJIJmKGWwaHHuZ4VlKGK7IFjU	NYnYS4szRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzOlY3PjVpPkK0N\|Y3PjZ3PD;hQi=>
G7	M1vpZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NIS4fVlKSzVyPUOuN{BvVQ>?	M1P4[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MkC0O\|M{Lz5{NEKwOFc{OzxxYU6=
G166	MoHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M{PZSmlEPTB;Nz6wJI5O	NHfxeoY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEKwOFc{Oyd-MkSyNFQ4OzN:L3G+
CB660	NEDld4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFPNbJNKSzVyPU[uOEBvVQ>?	Mm\vQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{MES3N\|MoRjJ2MkC0O\|M{RC:jPh?=
CB1117	NF2zXohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3nyeWlEPTB;MUWuOkBvVQ>?	NVrNO25URGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyNFQ4OzNpPkK0NlA1PzN\|PD;hQi=>
KB-3-1	MoC5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MmDHTWM2OD1zLkS4JOKyKDBwNUOgcm0>	Mn:4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkK0OFUoRjJ\|OU[yOFQ2RC:jPh?=
KB-8-5-11	M3XCZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Ml7HTWM2OD13LkCxJOKyKDJwMEGgcm0>	M{jTNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OU[yOFQ2Lz5{M{m2NlQ1PTxxYU6=
KB-C-1	M3;lOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NUTiU\|hyUUN3ME2xOk44PiEEsTC0MlUyKG6P	M1\uVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OU[yOFQ2Lz5{M{m2NlQ1PTxxYU6=
KB-V-1	NXf6clBuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHPQcHRKSzVyPUK4NU4zPCEEsTCzNU42PyCwTR?=	NWHlU\|JPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5OlI1PDVpPkKzPVYzPDR3PD;hQi=>
OVCAR-8	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NIrsXphKSzVyPUeuNVkhyrFiMz62NEBvVQ>?	M1PPT\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OU[yOFQ2Lz5{M{m2NlQ1PTxxYU6=
NCI-ADR-RES	NF6xcnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M{\xcGlEPTB;MUK3N{4{OCEEsTCxPVEvOjBibl2=	MlHPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkK0OFUoRjJ\|OU[yOFQ2RC:jPh?=
MCF7	M3O5Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MkDnTWM2OD13LkGxJOKyKDFwNEegcm0>	MlXGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkK0OFUoRjJ\|OU[yOFQ2RC:jPh?=
MCF7-FLV1000	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4PMOmlEPTB;M{mzMlE5KMLzIEe0Mlg{KG6P	NV2yV4hzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5OlI1PDVpPkKzPVYzPDR3PD;hQi=>
S1	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NHrzXVdKSzVyPUK0MlMxKMLzIESuO\|Uhdk1?	MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4MkS0OUc,OjN7NkK0OFU9N2F-
S1-M1-80	NULYPHZPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MlLTTWM2OD1{NkGuNFYhyrFiNEiuNlUhdk1?	M1HGNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OU[yOFQ2Lz5{M{m2NlQ1PTxxYU6=
CORL-23/P	M1fob2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2HUOWlEPTB;ND6zPEDDuSBzLkK1JI5O	NHPqUHU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2NlQ1PSd-MkO5OlI1PDV:L3G+
CORL-23/R	Ml[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlvDTWM2OD13LkG2JOKyKDFwOEOgcm0>	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4MkS0OUc,OjN7NkK0OFU9N2F-
NIH3T3	NHfCR\|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXvJR\|UxRTRyLk[wJOKyKDRwOUegcm0>	NIf5TXY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2NlQ1PSd-MkO5OlI1PDV:L3G+
NIH3T3-G185	MoHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NWDJUFJHUUN3ME2yOFE{NjRyINMxJFQzOy54NjDuUS=>	NILYWpM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2NlQ1PSd-MkO5OlI1PDV:L3G+
pcDNA-HEK293	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NUHMeY97UUN3ME2yMlc2KMLzIECuOlchdk1?	NXz5WVU{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5OlI1PDVpPkKzPVYzPDR3PD;hQi=>
MDR19-HEK293	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MoTvTWM2OD16NT61NEDDuSBzMz62O{BvVQ>?	NVHlbGR2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5OlI1PDVpPkKzPVYzPDR3PD;hQi=>
R482-HEK293	NH2yW\|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NGjjdY5KSzVyPUK1Mlk4KMLzIESuPVUhdk1?	NWXEfJQzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5OlI1PDVpPkKzPVYzPDR3PD;hQi=>
MRP1-HEK293	MnjmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVm5PYIxUUN3ME2yMlk6KMLzIEGuOFkhdk1?	NVq0RXFXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5OlI1PDVpPkKzPVYzPDR3PD;hQi=>
SF188	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGPv[WIyOC1zMECgcm0>	M3n0fFI1NTl4IHi=	M1HJXGROW09?	NH\SUINqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDic5RpKHSrbXWtJIFv\CClb37j[Y51emG2aX;uMUBl\XCnZHXueEBu[W6wZYK=	NFPLeI49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{i4O\|Y1PSd-MkO4PFc3PDV:L3G+
T98G	MoTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHfIXXcyOC1zMECgcm0>	MV6yOE06PiCq	MYrEUXNQ	M3nufolvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHPvcoNmdnS{YYTpc44uKGSncHXk[Y51KG2jbn7ldi=>	NYDw[2dwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4PFc3PDVpPkKzPFg4PjR3PD;hQi=>
DU145	MoSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MYjEUXNQ	NHLuW29KSzVy4pk8OlAhdk1?	MljoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6OES0NlgoRjJ\|OEi0OFI5RC:jPh?=
LNCaP	NVeyN5BUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NUTyTFVlTE2VTx?=	MW\JR\|Ux6oj:N{Wgcm0>	NE\FWWg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{i4OFQzQCd-MkO4PFQ1Ojh:L3G+
PC3	M1Pm[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MlLLSG1UVw>?	M{\VXWlEPTEkiMyxO\|Uhdk1?	NETSco89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{i4OFQzQCd-MkO4PFQ1Ojh:L3G+
RT4	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Ml3iTWM2OD1{Nz6yNUBvVQ>?	NIDYb\|k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{e5NlY{QSd-MkO3PVI3Ozl:L3G+
5637	NIDjcmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1jyfGlEPTB;NEWuOFchdk1?	MkjkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5OUK2N\|koRjJ\|N{myOlM6RC:jPh?=
T24	M{j2Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1LzXGlEPTB;N{muNVIhdk1?	M4H4PFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|N{myOlM6Lz5{M{e5NlY{QTxxYU6=
MCF7	NIfieldHfW6ldHnvckBCe3OjeR?=	M{SwZ\|ExOCCwTR?=	NVz6NldZOSCq	MlzySG1UVw>?	MYny[YR2[2W\|IITo[UBqdmS3Y4Tpc44hd2cEoFfy[YIyNMLiU3frNUzDqFC\|Mj\|CpHNmenCrbnGzMEBidmUEoGfpd5Az	MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd5MEK0OEc,OjN5N{CyOFQ9N2F-
KB-V1	M4TTTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MkDCTWM2OD1\|LkmyJO69VQ>?	NVTHdG9kRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1PVMyQTZpPkKzOVk{OTl4PD;hQi=>
Hec50co	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnHkTWM2OD13IH7N	M1X5TFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MUS2Olg4Lz5{M{G0OlY5PzxxYU6=
MDA-MB-468	NVy0O5p2SXCxcITvd4l{KEG\|c3H5	M2nHRlEwPS9zMDDuUS=>	NHnZRpQzPC92OD:3NkBp	NVXnO4RTTE2VTx?=	MnPMbY5lfWOnczDhdI9xfG:\|aYOgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK=	M1vnelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MUS0Nlk1Lz5{M{G0OFI6PDxxYU6=
MCF10A	MXLBdI9xfG:\|aYOgRZN{[Xl?	M3;yW\|EwPS9zMDDuUS=>	MkT6NlQwPDhxN{KgbC=>	MWLEUXNQ	NVrxcW9xcW6mdXPld{BieG:ydH;zbZMhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI>	MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzF2NEK5OEc,OjNzNESyPVQ9N2F-
Huh-7	NVrtW2ViT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWrFWIhMOS9zMD:xNFAwOTByMDDuUS=>	MX[0PEBp		NXXNPZhr\GWlcnXhd4V{KHSqZTDj[YxtKH[rYXLpcIl1gSCmb4PlMYRmeGWwZHXueIx6	NXToXpZpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK3OFU2QDdpPkKyO\|Q2PTh5PD;hQi=>
Daoy	NHizdlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmLFNU45PzVvMkSwJI5O	M4DzbVczKGh?	NUCzRYtpTE2VTx?=	M3HLO2lEPTB;NTDuUS=>	MkXFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ\|OUCyO\|koRjJ{M{mwNlc6RC:jPh?=
ONS-76	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlHhNU45PzVvMkSwJI5O	NFzwW3U4OiCq	M{m2PWROW09?	NEDQ[4RKSzVyPUeuOUBvVQ>?	M4n3dVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{mwNlc6Lz5{MkO5NFI4QTxxYU6=
SUM 149	MojmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlXvNE0yODBibl2=	Mn\ZO\|IhcA>?		NVT5bHpVcW6qaXLpeJMhfGinIHPlcIwhfmmjYnnsbZR6KGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoFz	NWiydlVPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzNFk6OzlpPkKyN\|A6QTN7PD;hQi=>
MDA-MB-231	NV[ydXA3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkfrNE0yODBibl2=	NFjtTIQ4OiCq		MljMbY5pcWKrdIOgeIhmKGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnHy	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjNyOUmzPUc,OjJ\|MEm5N\|k9N2F-
HR5	M17teGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEK5d\|kxNTFyMDDuUS=>	MUS3NkBp		MUDpcohq[mm2czD0bIUh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wYYK=	MkThQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ\|MEm5N\|koRjJ{M{C5PVM6RC:jPh?=
BT-474-M1	NH\sWVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkDMNE0yODBibl2=	NXv2VmJnPzJiaB?=		NWLwVpducW6qaXLpeJMhfGinIHPlcIwhfmmjYnnsbZR6KGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoFz	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjNyOUmzPUc,OjJ\|MEm5N\|k9N2F-
AU565	NUj3bY9jT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3jYWVAuOTByIH7N	M4\JZ\|czKGh?		M4GwZ4lvcGmkaYTzJJRp\SClZXzsJJZq[WKrbHn0fUBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7hdi=>	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjNyOUmzPUc,OjJ\|MEm5N\|k9N2F-
T47D	NWHiOGFvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NX7aPXRpOC1zMECgcm0>	NYjsXHg4PzJiaB?=		M4[3b4lvcGmkaYTzJJRp\SClZXzsJJZq[WKrbHn0fUBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7hdi=>	NUL2W45ZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzNFk6OzlpPkKyN\|A6QTN7PD;hQi=>
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Fibroblast cells	MWrxTHRUKGG\|c3H5				NWjlboJleUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IHPvcpRzd2xiSHige4lt\CC2eYDlJIZq[nKxYnzhd5Qh[2WubIO=	NGHaXIQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
NB-EBc1	MUDxTHRUKGG\|c3H5				MoPPdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgUmIuTUKlMTDj[Yxtew>?	MnvHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
SK-N-SH	MY\xTHRUKGG\|c3H5				MVXxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDTT{1PNVOKIHPlcIx{	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
A673	NWHR[JV5eUiWUzDhd5NigQ>?				MYjxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDBOlc{KGOnbHzzLS=>	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
BT-37	MV3xTHRUKGG\|c3H5				NEflTJlyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBDXC1\|NzDj[Yxtew>?	MmfPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
MG 63(6-TG R)	NFfpSVVyUFSVIHHzd4F6				M2HMPZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJG1IKDZ\|IDi2MXRIKFJrIHPlcIx{	M3fWfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
Fibroblast cells	NFm1fWNyUFSVIHHzd4F6				MUfxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDjc451em:uIFjoJJdqdGRidInw[UBncWK{b3LsZZN1KGOnbHzz	MmX5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
OHS-50	NInNNVZyUFSVIHHzd4F6				MY\xTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDPTHMuPTBiY3XscJM>	MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
RD	M1GzfJFJXFNiYYPzZZk>				MYrxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDSSEBk\Wyucx?=	M1SwZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SJ-GBM2	MWLxTHRUKGG\|c3H5				M2\wNJFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCVSj3HRm0zKGOnbHzz	NFO1bmI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
SK-N-MC	NGDGNIpyUFSVIHHzd4F6				MlL0dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKFONLV6tUWMh[2WubIO=	NWP2b\|hrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
NB-EBc1	M3\jd5FJXFNiYYPzZZk>				M2rsOZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCQQj3FRoMyKGOnbHzz	NWDqdoRoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
LAN-5	M{e5NZFJXFNiYYPzZZk>				M3q0b5FJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCOQV6tOUBk\Wyucx?=	NUjOWJRuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
Rh18	M{Du[pFJXFNiYYPzZZk>				MX;xTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhWmhzODDj[Yxtew>?	NXvZcoJmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
NB1643	NXL0eHFjeUiWUzDhd5NigQ>?				M161VZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJG5DOTZ2MzDj[Yxtew>?	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
SK-N-MC	NWqxdmRzeUiWUzDhd5NigQ>?				M{HCRZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJHNMNU5vTVOgZ4VtdHN?	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
SJ-GBM2	MojPdWhVWyCjc4PhfS=>				NUnqNWdzeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhW0pvR1LNNkBk\Wyucx?=	MornQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
TC32	NHO5S4VyUFSVIHHzd4F6				NWH1b251eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhXEN\|MjDj[Yxtew>?	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
Rh18	M17oTJFJXFNiYYPzZZk>				MnnqdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgVogyQCClZXzsdy=>	MnXxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
Saos-2	NWSxV2Z3eUiWUzDhd5NigQ>?				MWTxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDTZY9{NTJiY3XscJM>	NIPKelY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
DU145	MXvBdI9xfG:\|aYOgZZN{[Xl?	MXWxNFAhdk1?	MYOyOEBpenN?		MUPJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKESXMUS1JINmdGy\|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKFCDUmCgZ4xm[X[jZ3WgZZQhOTByIH7NJIFnfGW{IEK0JIhzeyCkeTDpcY12dm:kbH;0eIlv\yCvZYToc4Q>	MlTMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4OEW5OFEoRjJ3Nki1PVQyRC:jPh?=
HeLa	NWntfWJ2TnWwY4Tpc44h[XO\|YYm=	NH;UPVAyODBibl2=			MX\Jcohq[mm2aX;uJI9nKFCOS{GgWIhzOjFyIIDoc5NxcG:{eXzheIlwdiCrbjDoeY1idiCKZVzhJINmdGy\|IHH0JFExOCCwTTDifUBqdW23bn;icI91fGmwZzDt[ZRpd2R?	NF\4SJM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[4OVk1OSd-MkW2PFU6PDF:L3G+
DU145	NIjXepBHfW6ldHnvckBie3OjeR?=	MXexNFAhdk1?			NFj3T2ZKdmirYnn0bY9vKG:oIGDMT\|EheHKxdHXpckBi[2O3bYXsZZRqd25iaX6gbJVu[W5iRGWxOFUh[2WubIOgZZQhOTByIH7NJIJ6KGmvbYXuc4Jtd3S2aX7nJI1mfGixZB?=	M2D4fFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Nki1PVQyLz5{NU[4OVk1OTxxYU6=
HeLa	MorFSpVv[3Srb36gZZN{[Xl?	M17zOVExOCCwTR?=			NH7pSoNKdmirYnn0bY9vKG:oIGDMT\|EheHKxdHXpckBi[2O3bYXsZZRqd25iaX6gbJVu[W5iSHXMZUBk\WyuczDheEAyODBibl2gZpkhcW2vdX7vZoxwfHSrbnegcYV1cG:m	MmP1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4OEW5OFEoRjJ3Nki1PVQyRC:jPh?=
HeLa	M{jOeWZ2dmO2aX;uJIF{e2G7	MYGxNFAhdk1?	MlXmNVghcHK\|		NVfTfpluUW6mdXP0bY9vKG:oIH3vco9xd2yjcjDtbZRwfGmlIIPwbY5ldGW\|IHnuJIh2dWGwIFjlUIEh[2WubIOgZZQhOTByIH7NJIlv[3WkYYTl[EBnd3JiMUigbJJ{KGK7IHnu[Ilz\WO2IHntcZVvd2[udX;y[ZNk\W6lZTDtbYNzd3Olb4D5	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ6NUm0NUc,OjV4OEW5OFE9N2F-
HeLa	NVj0XYQySXCxcITvd4l{KGG\|c3H5	MYqxNFAhdk1?	NFXFUI0zPCCqcoO=		MX3JcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKEinTHGgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hWEGUUDDjcIVifmGpZTDheEAyODBibl2gZYZ1\XJiMkSgbJJ{KGK7IHntcZVvd2Kub4T0bY5oKG2ndHjv[C=>	Ml3RQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4OEW5OFEoRjJ3Nki1PVQyRC:jPh?=
PC3	MmHPSpVv[3Srb36gZZN{[Xl?	NULKS4pKOTByIH7N	M1;6TFE5KGi{cx?=		MnnyTY5lfWO2aX;uJI9nKG2xbn;wc4xieiCvaYTveIlkKHOyaX7kcIV{KGmwIHj1cYFvKFCFMzDj[YxteyCjdDCxNFAhdk1iaX7jeYJifGWmIH\vdkAyQCCqcoOgZpkhcW6maYLlZ5QhcW2vdX7v[ox2d3Knc3PlcoNmKG2rY4Lvd4NweHl?	NXHjTXIyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2PFU6PDFpPkK1Olg2QTRzPD;hQi=>
DU145	MlzvSpVv[3Srb36gZZN{[Xl?	M4XYZVExOCCwTR?=			MUjJcohq[mm2aX;uJI9nKFCOS{GgWIhzOjFyIIDoc5NxcG:{eXzheIlwdiCrbjDoeY1idiCGVUG0OUBk\WyuczDheEAyODBibl2gZpkhcW2vdX7vZoxwfHSrbnegcYV1cG:m	MkLRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4OEW5OFEoRjJ3Nki1PVQyRC:jPh?=

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	pro-caspase-8 / cleaved caspase-8 / cleaved caspase-3 / cleaved caspase-9; PubMed: 27699933 Cancer Sci PLKi‐induced caspase activation. HeLa cells were treated with BI 2536 (10 nmol/L), BI 6727 (68 nmol/L), or GSK461364 (11 nmol/L), and HCT 116 cells were treated with BI 2536 (20 nmol/L), BI 6727 (70 nmol/L), or GSK461364 (12 nmol/L) for 48 h. The levels of cleaved caspase (CASP)‐3, ‐8, and ‐9 were examined by Western blot analysis. p-HH3 / PARP / Myc / p-Myc; PubMed: 24771642 Clin Cancer Res Western blotting showing more mitotic arrested (shown by phospho-histone H3) and apoptotic (shown by PARP) cells as well as lower MYC levels in LNCaP-Pim1 cells after BI 2536 treatment compared with LNCaP-Neo cells. The difference is obvious at lower dose of BI 2536 (10 nM). Both total MYC expression and phosphor-MYC levels were lower in Pim1 cells than Neo cells after BI 2536 treatment. pMEK / MEK / pERK / ERK / pRSK1 / RSK1; PubMed: 28430578 Oncotarget (A) and (B) Western blot analysis of the expression and activation of components of the MEK-ERK-RSK1 pathway in MKN45 and MKN74 cancer cells treated with BI 2536 and BI 6727 for 24 and 48 hours, respectively. pPlk1 / Plk1 / pMyt1; PubMed: 28430578 Oncotarget (A) and (B) Western blot analysis of the expression and phosphorylation of Plk1, and phosphorylation of Myt1 in the CSC-like and cancer cells after treatment with BI 2536 and BI 6727 for 24 and 48 hours, respectively. Aurora B / pAurora B / pAurora C / pH3 / Cyclin B1 / Securin / pBcl-XL / MPM2; PubMed: 25169932 Mol Oncol Western blot analysis of cells treated for 24 h with the indicated inhibitor concentrations. Cell lysates were immunoblotted for Plk1, Phospho-Aurora B (T232)/Aurora C (T198), Aurora B, histone H3 phosphorylated at S10 (pH3), Cdk1, Cyclin B1, Securin, Phospho-Bcl-XL, Induced myeloid leukemia cell differentiation protein Mcl-1, MPM-2 and β-Actin. Left (Hela cells); Right (HUVEC)	27699933 24771642 28430578 25169932
Immunofluorescence	p-H2AX / propidium iodide; PubMed: 22309939 Breast Cancer Res Apoptotic images of the cells after BI 2536 treatment, as revealed by HCS (high-content screening) instrument (×10) with phospho-H2AX antibody or PI (propidium iodide) intake. Pericentrin / α-tubulin; PubMed: 21772266 Nat Commun MEFs were labelled using Plk1, pericentrin and α-tubulin antibodies and 4,6-diamidino-2-phenylindole for the analysis by immunofluorescence microscopy. Representative examples of BI 2536-treated and control MEFs are depicted. Scale bar, 5 μm.	22309939 21772266
Growth inhibition assay	Cell viability; PubMed: 21772266 Nat Commun Proliferative activity of MEFs at different BI 2536 concentrations (25–250 nM; means±s.d., n=3, for each concentration). P<0.05, P<0.01, **P<0.001, Student's t-test, unpaired and two-tailed.	21772266

体内研究

BI 2536静脉注射给药多种移植瘤模型，每周一次或两次，效果都很好，通过使细胞周期停滞而抑制细胞增殖，随后诱导肿瘤细胞死亡。BI 2536按 50 mg/kg剂量处理HCT 116移植瘤，每周一次或两次，显著抑制肿瘤生长，T/C 分别为15%和0.3%。BI 2536每周处理两次BxPC-3和A549模型，也显著抑制肿瘤生长，T/C分别为5% 和14%。^[1]

激酶实验： ^[1]	- 合并体外Plk1激酶实验: 重组人Plk1 (1-603残基) 作为氮端，携带杆状病毒表达系统的GST-标记的融合蛋白通过亲和层析，使用谷胱甘肽-琼脂糖而纯化。在梯度稀释的BI 2536存在时，使用 20 ng 重组激酶，及10 μg牛奶中的酪蛋白作为底物进行Plk1 酶活性实验。在终体积为60 μL 的混合物(15 mM MgCl₂, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-³³P-ATP)中30^oC下进行激酶反应45分钟。加入 125 μL 冰冻的5% TCA终止反应。沉淀物转移到混合酯纤维素的多屏过滤板上，使用1% TCA冲洗实验板，然后利用放射性进行测量。绘制剂量反应曲线，而计算IC50值。
细胞实验： ^[1]	- 合并 Cell lines: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji, PC-3,等等 Concentrations: 溶于DMSO, 终浓度为~1 μM Incubation Time: 24,和72小时 Method: 使用不同浓度BI 2536处理细胞24和72小时。在荧光分光光度计中测量Alamar Blue染料转换而测定细胞生长。为了测定培养基中DNA含量，细胞悬液在80%乙醇中混合, 使用溶于PBS的0.25% Triton X-100处理5分钟，然后与0.1% RNase 和溶于PBS的 10 μg/mL碘化丙啶在室温下温育20分钟。通过流式细胞仪分析而测定细胞周期谱。 (Only for Reference)
动物实验： ^[1]	- 合并 Animal Models: 皮下注射HCT 116, NCI-H460, 或A549 细胞的雌性BomTac:NMRI-Foxn1nu 小鼠 Dosages: ~50 mg/kg Administration: 静脉注射，每周一到两次 (Only for Reference)

参考文献

溶解度 (25°C)

体外	Ethanol	100 mg/mL (191.69 mM)
	DMSO	21 mg/mL (40.25 mM)
	Water	Insoluble
体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： 30% PEG 400+0.5% Tween 80+5% Propylene glycol	15mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download BI 2536 SDF

分子量	521.66
化学式	C₂₈H₃₉N₇O₃
CAS号	755038-02-9
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	N/A

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

临床试验信息 (data from https://clinicaltrials.gov, updated on 2020-01-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT02215044	Terminated	Drug: BI 2536 intravenous\|Drug: Gemcitabine intravenous	Pancreatic Neoplasms	Boehringer Ingelheim	June 2007	Phase 1
NCT02211833	Completed	Drug: BI 2536\|Drug: Pemetrexed	Carcinoma Non-Small-Cell Lung	Boehringer Ingelheim	October 2006	Phase 1
NCT00701766	Completed	Drug: BI 2536	Leukemia Myeloid Acute	Boehringer Ingelheim	October 2006	Phase 2
NCT00706498	Completed	Drug: BI 2536	Prostatic Neoplasms	Boehringer Ingelheim	September 2006	Phase 2
NCT00376623	Completed	Drug: BI 2536	Carcinoma Non-Small-Cell Lung	Boehringer Ingelheim	July 2006	Phase 2
NCT02211872	Completed	Drug: BI 2536 BS intravenous	Neoplasms	Boehringer Ingelheim	August 2004	Phase 1

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

常见问题及建议解决方法

问题 1：
We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?
回答：
For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

PLK Signaling Pathway Map

PLK Inhibitors with Unique Features

选择性强的Plk抑制剂

GSK461364 : Plk1-selective, K_i=2.2 nM.
用于临床的Plk抑制剂

Rigosertib (ON-01910) : Phase III for Myelo Dysplastic Syndrome (MDS).
最新的Plk抑制剂

Ro3280 ^New : Potent, highly selective inhibitor of Polo-like kinase 1 (PLK1) with IC50 of 3 nM.
经典的Plk抑制剂

Volasertib (BI 6727) : Highly potent Plk1 inhibitor with IC50 of 0.87 nM and in phase II trials.

研究领域

产品类型

定制您的化合物库

BI 2536

客户使用Selleck生产的BI 2536发表文献209篇：

产品安全说明书

PLK抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download BI 2536 SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

临床试验信息 (data from https://clinicaltrials.gov, updated on 2020-01-06)

技术支持

常见问题及建议解决方法

PLK Signaling Pathway Map

PLK Inhibitors with Unique Features

相关PLK产品