BI 2536

目录号：S1109

BI 2536 Chemical Structure

Molecular Weight(MW): 521.66

BI 2536是一种有效的Plk1抑制剂，无细胞试验中IC50为0.83 nM，比作用于Plk2和Plk3选择性分别高4和11倍。Phase 2。

规格 价格 库存 购买数量  
RMB 1978.87 现货
RMB 981.57 现货
RMB 1704.35 现货
RMB 5492.59 现货
RMB 8160.83 现货
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客户使用Selleck该产品发表文献56篇：

客户使用该产品的13个实验数据：

  • (C) HeLa cells were treated with inhibitors of Aurora B (hesperadin), Aurora A (Aurora A inhibitor I), CDK1 (roscovitine), or PLK1 (BI2536) for 2 hours before immunostaining for tubulin and phosphorylated RV[S/T]F (p-RV[S/T]F). Nuclei are indicated with DAPI. Control cells were not treated with any inhibitor. More than 50 cells were imaged for each condition in three independent experiments. Scale bar, 20 μm.

    Science, 2018, 11(530), doi: 10.1126/scisignal.aai8669. BI 2536 purchased from Selleck.

    Comparison between Genetic Ablation of Cdc20 and Current Mitotic Drugs (C) Transformed Cdc20(lox/lox); RERT(+/Cre) MEFs were subcutaneously injected into the two flanks of SCID mice, and tumors were scored every 2-3 days.These mice were injected i.p. (three injections per week) with 4-OHT or mitotic drugs (taxol, vincristine, and BI2536) when tumors reached about 200 mm3 of volume (day 11; arrow) (n = 8 mice per group). (D) Representative images of these fibrosarcomas 3 days after injection with 4-OHT (to generate Cdc20(D/D) cells), BI2536, or taxol. These mice were injected with 10 μM BrdU to score DNA replication. CA3, immunodetection of active caspase 3. Scale bars, 50 or 10 μM (insets).

    Cancer Cell 2010 18, 641–654. BI 2536 purchased from Selleck.

  • (a,b) RPE1 cells transfected with control or either of two B56-PP2A siRNA pools (1, 2) were incubated in MG132 (10µM, 15 min), followed by the addition of BI2536 (40 nM) or DMSO for 45 min. (a) The frequency of mitotic cells with few or absent cold-stable K-bres . (b) Maximum-intensity projection of tubulin (green) and an overlay with kinetochores (CREST, red) in B56-PP2A-siRNA (pool 2) cells treated with DMSO or BI2536 (40 nM). Insets are 3 enlargement of the optical sections spanning the outlined centromeres.

    Nat Cell Biol 2011 13, 1265-71. BI 2536 purchased from Selleck.

    (a) HeLa Tet-On cells were treated with the indicated siRNAs, arrested in mitosis using 500 nM nocodazole (Noc) and 10 μM MG132, and then treated with or without BI 2536. The endogenous Cdc20 was immunoprecipitated from these cells and blotted with the indicated antibodies. The mitotic index of each sample is indicated below each lane. The bottom graph shows the quantification of the Cdc20-pS92 signal normalized to the total Cdc20 signal (mean±range; n=2 independent experiments).

    Nat Commun, 2016, 7:10818. BI 2536 purchased from Selleck.

  • Treatment with BI 2536 induces cell-cycle arrest in NB TICs and aberrant accumulation of cyclin B1 and p21. C, expression of cyclin B1 and p21 was assessed in NB88R2 following 16 and 24-hour treatment with different doses of BI 2536 (10, 30, and 100 nmol/L). ERK1 (extracellular signal regulated kinase 1) was used as the loading control. D, inhibition of PLK1 was assessed by in vitro kinase assay following treatment of NB88R2 for 3 hours with BI 2536.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

    Treatment with BI 2536 induces cell death via apoptosis. A,treatment with BI 2536 (10, 30, and 100 nmol/L) reduces viable cell numbers as assessed by trypan blue exclusion. B, representative Western blot demonstrating accumulation of cleaved PARP following treatment with 10 nmol/L BI 2536.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

  • BI 2536 inhibits NB tumor growth in vivo. A and B, NOD/SCID mice bearing 50- to100-mm3 tumors were injected intravenously with either vehicle (0.1N HCl per saline) or 12.5 to 25 mg/kg BI 2536 for 2 consecutive days a week, for a total of 3 cycles.Two independent experiments were performed in each case with 5 animals per group. Representative tumor growth data are shown.

     

     

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

    animals with 50- to 100-mm3 tumors were randomized into 4 groups: group 1 injected intravenously with vehicle (0.1N HCl per saline), group 2 injected intravenously with 12.5 mg/kg of BI 2536 (2 consecutive days, 3 cycles), group 3 injected i.p. with 10 mg/kg of irinotecan (3 doses total, 3 days apart), and group 4 injected with BI 2536 and irinotecan. Both representative tumor growth data and a Kaplan-Meyer survival plot are shown.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

  • Plk-1 knockdown and inhibition by BI 2536 and viability of human melanoma cell lines M14 and WM-115 as demonstrated by MTT assay. Experiments were performed in triplicate. One representative experiment is shown. *P<0.001, ANOVA test with Tukey’s post-test. ANOVA, analysis of variance; MTT, 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; Plk-1, polo-like kinase 1; siRNA, small-interfering RNA; WB, western blot.

    J Invest Dermatol 2011 131, 1886–1895. BI 2536 purchased from Selleck.

    Western blot analysis of the expression and phosphorylation of Plk1, and phosphorylation of Myt1 in the CSC-like cells after treatment with BI 2536 for 24 and 48 hours, respectively.

    Oncotarget, 2017, 8(23):37633-37645. BI 2536 purchased from Selleck.

  • Cells with decreased GRK5 expression are more sensitive to PLK1 inhibition.A , shown is cell death in control or GRK5-shRNA stably transfected cells after 72 h of treatment with 0-120 nM BI 2536 as determined by trypan blue exclusion (n = 6).B , shown is cell death in control or GRK5-shRNA stably transfected cells after 72 h treatment with 0 –120 nM GSK461364, as determined by trypan blue exclusion ( n = 4).

    J Biol Chem 2012 287(21), 17088-99. BI 2536 purchased from Selleck.

    J Biomol Screen 2013 18(1), 54-66. BI 2536 purchased from Selleck.

  • Example dose response curves of the PLK-1 inhibitor BI-2536. During the large dose response study for each reference compounds 8 dilutions were tested. Curves for IC50 determination for two independent experiments for the PLK1 inhibitor BI-2536 are displayed. This inhibitor is also used to achieve the LC values. IC50 has been determined with 7.48 +/- 0.09 log [M] and 6.75 +/- 0.21 log [M]. Correlating assay performance data are displayed in Suppl. Fig. 5. 

    J Biomol Screen 2013 18(1), 54-66. BI 2536 purchased from Selleck.

产品安全说明书

PLK抑制剂选择性比较

生物活性

产品描述 BI 2536是一种有效的Plk1抑制剂，无细胞试验中IC50为0.83 nM，比作用于Plk2和Plk3选择性分别高4和11倍。Phase 2。
特性 BI 2536是第一个有效的Plk1选择性抑制剂，抑制 Plk1的标记。
靶点
PLK1 [1]
(Cell-free assay)		 PLK2 [1]
(Cell-free assay)		 PLK3 [1]
(Cell-free assay)
0.83 nM 3.5 nM 9.0 nM
体外研究

除了Plk1, BI 2536也抑制 Plk2 和Plk3活性，只是抑制程度低点,IC50分别为3.5 nM和9.0 nM。BI 2536比一组63种其他蛋白激酶（IC50>10 μM）选择性高1000多倍。BI 2536 按10 nM 到 100 nM剂量作用于HeLa细胞，抑制有丝分裂中心体中γ-微管蛋白招募和Apc6 磷酸化，抑制染色体臂中释放黏结蛋白, 诱导产生单极主轴，及一些依赖Plk1的其他有丝分裂过程。与作用于Plk1 RNAi效果相一致, BI 2536处理HeLa细胞，使细胞周期停在G2/M期, 随后DNA分解及凋亡，且累积断裂的PARP p85片段，这种作用存在浓度依赖性。BI 2536抑制一组32种人肿瘤细胞系生长，EC50为2-25 nM,抑制指数生长的hTERT-RPE1,人脐静脉内皮细胞 (HUVECs),和正常大鼠肾脏(NRK) 细胞的增殖，EC50为12-31 nM。[1] BI 2536 抑制Plk1，降低甲状腺未分化癌(ATC)细胞如 CAL62, OCUT-1, SW1736, 8505C,和 ACT-1 的生长的生长和活力，EC50为1.4-5.6 nM。[2]
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PSN1 M1Ln[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfhTWM2OD1yLkCwO|c3KM7:TR?= NWfNbokzW0GQR1XS
ACN M1K0Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrYd2hGUUN3ME2wMlAxQDR|IN88US=> MlThV2FPT0WU
TE-8 M33wc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLsbGt[UUN3ME2wMlAxQTRzIN88US=> MnvFV2FPT0WU
LC-2-ad MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrvO|dKSzVyPUCuNFExQTNizszN MmPZV2FPT0WU
ALL-PO NHG5VFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTBwMEGzJO69VQ>? NFrtfnhUSU6JRWK=
EW-16 NGCyeXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTBwMEGzN|Yh|ryP NEWy[pVUSU6JRWK=
KM12 M1LCV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDUTWM2OD1yLkCxN|Q5KM7:TR?= NIj2Tm9USU6JRWK=
GI-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfOVVh6UUN3ME2wMlAyOzh|IN88US=> M4fEb3NCVkeHUh?=
LS-411N M3r6[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwMEG0NFch|ryP NUCwbYp5W0GQR1XS
ES8 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfMTWM2OD1yLkCxOFk1KM7:TR?= M1vw[3NCVkeHUh?=
SNU-C2B MlHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrmN|NKSzVyPUCuNFE2OjZizszN MmrZV2FPT0WU
CESS M2eyPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfyNY9KSzVyPUCuNFE3ODJizszN MmLSV2FPT0WU
697 M3\5ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfu[FNIUUN3ME2wMlAyPjZ6IN88US=> NIXoXG5USU6JRWK=
NCI-H1963 MorXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWi5PJVoUUN3ME2wMlAyPjd|IN88US=> MX3TRW5ITVJ?
IA-LM NXe1cWZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XrS2lEPTB;MD6wNVY5QCEQvF2= M{XOTnNCVkeHUh?=
SW954 NFLjVVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHsZ|JKSzVyPUCuNFE4ODVizszN NVfsb5p2W0GQR1XS
RL95-2 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwMEG3N|gh|ryP NF\oUZNUSU6JRWK=
LXF-289 NIToc5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDTXnk3UUN3ME2wMlAyPzdizszN MVnTRW5ITVJ?
OCUB-M NXTQZnAyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwMEG4NlYh|ryP MnPiV2FPT0WU
RKO MknvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUmycpQyUUN3ME2wMlAyQTh5IN88US=> M{[wOXNCVkeHUh?=
LOUCY NWfm[lg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoH5TWM2OD1yLkCyNFUh|ryP M4KxS3NCVkeHUh?=
NOS-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTvTWM2OD1yLkCyNFk{KM7:TR?= MYrTRW5ITVJ?
A4-Fuk MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;GPHA{UUN3ME2wMlAzOjF6IN88US=> NGTqbpBUSU6JRWK=
A388 NUXMV2JxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPxbmo3UUN3ME2wMlAzOjJ5IN88US=> MVnTRW5ITVJ?
TE-9 Mn21S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPZOVFXUUN3ME2wMlAzOjZzIN88US=> MUjTRW5ITVJ?
KURAMOCHI NXyxbFNLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXHR3BKSzVyPUCuNFIzQDVizszN NVPyN2Y3W0GQR1XS
KALS-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLzN25KSzVyPUCuNFI{OzhizszN NWLYXm8xW0GQR1XS
HOP-62 NXW0XZJCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwMEK0NkDPxE1? NHvmSYxUSU6JRWK=
RPMI-8402 NF\uUmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;5SW9KSzVyPUCuNFI2ODhizszN NWfBbm5qW0GQR1XS
TE-1 NUC4PWJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFexZW5KSzVyPUCuNFI2OTJizszN MUjTRW5ITVJ?
CCRF-CEM MnjkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXyTWM2OD1yLkCyOVQ{KM7:TR?= NHfsN49USU6JRWK=
HUTU-80 NHjGdWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwMEK2NlQh|ryP M13hc3NCVkeHUh?=
NCI-H1648 NWH0[HhVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1KzNmlEPTB;MD6wNlY1PyEQvF2= M3O3fXNCVkeHUh?=
HCE-4 MkTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPYO45KSzVyPUCuNFI3QDJizszN NH;jUplUSU6JRWK=
ETK-1 NUXCXWFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3yTWM2OD1yLkCyO|M3KM7:TR?= NGC5[4FUSU6JRWK=
TE-15 M2fjPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzJTWM2OD1yLkCyO|M5KM7:TR?= NWX4bmt1W0GQR1XS
BE-13 NELpPZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTFZWxCUUN3ME2wMlAzPzRizszN NV\hWWJvW0GQR1XS
KE-37 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDPTWM2OD1yLkCyO|QyKM7:TR?= M4rRTHNCVkeHUh?=
NCI-H1355 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTBwMEK3PFMh|ryP MljSV2FPT0WU
TE-11 MnrxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXLTWM2OD1yLkCyPFA6KM7:TR?= NH;1em1USU6JRWK=
BL-70 Mmm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4CzWWlEPTB;MD6wNlg2PyEQvF2= NVXOZ5cyW0GQR1XS
ES6 Mmr3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jaOGlEPTB;MD6wNlg5OSEQvF2= MVLTRW5ITVJ?
GT3TKB M1PuSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwMEK5OVMh|ryP MmLwV2FPT0WU
LB647-SCLC NUC5R3l7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3YTWM2OD1yLkCzNVk2KM7:TR?= NFXYUJNUSU6JRWK=
NB13 MlnHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHxNXdNUUN3ME2wMlA{OzF4IN88US=> M1rHdHNCVkeHUh?=
ST486 MonYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;NTWM2OD1yLkCzN|M4KM7:TR?= M1nCcnNCVkeHUh?=
NCI-H82 MnzVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfE[m9KSzVyPUCuNFM{PDNizszN MVvTRW5ITVJ?
NTERA-S-cl-D1 MknaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF34Z3NKSzVyPUCuNFM{QTlizszN NF3kZYhUSU6JRWK=
ES4 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnGyTWM2OD1yLkCzOFY{KM7:TR?= M4PNb3NCVkeHUh?=
SK-NEP-1 M2SwUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIC5eIpKSzVyPUCuNFM1QTlizszN NITld4JUSU6JRWK=
Becker NI\s[3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXwenZRUUN3ME2wMlA{PTV3IN88US=> M3L5UHNCVkeHUh?=
A101D NGHj[VVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTBwMEO3OFgh|ryP M3juXXNCVkeHUh?=
SK-UT-1 M1vHemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwMEO3O|Qh|ryP MY\TRW5ITVJ?
SW982 NYPse2pNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPOZY9nUUN3ME2wMlA{PzlizszN M3G0eXNCVkeHUh?=
TE-10 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHCTWM2OD1yLkC0NFQ3KM7:TR?= NETWd4dUSU6JRWK=
OVCAR-4 MmnFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTBwMESwOVkh|ryP MUPTRW5ITVJ?
KP-N-YS NXzpVIFGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfQfGpKSzVyPUCuNFQxQDVizszN NYm1N2N4W0GQR1XS
BL-41 MnXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\WTWM2OD1yLkC0NVI2KM7:TR?= MV\TRW5ITVJ?
MZ1-PC MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jRUGlEPTB;MD6wOFEzPyEQvF2= M3PJZ3NCVkeHUh?=
PF-382 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTBwMESxPVgh|ryP NWO2ZXkxW0GQR1XS
MOLT-13 Mo\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTaTWM2OD1yLkC0NlM5KM7:TR?= NI\sZYdUSU6JRWK=
HCC1599 MmLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEWyUplKSzVyPUCuNFQzPThizszN NETufm1USU6JRWK=
IST-MEL1 M{SzZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LGPWlEPTB;MD6wOFQ1OiEQvF2= M3jJenNCVkeHUh?=
LU-139 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTBwMES0OFIh|ryP M4f5ZXNCVkeHUh?=
MS-1 M13USmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfzS5lKSzVyPUCuNFQ4ODFizszN M2TSUnNCVkeHUh?=
MFH-ino NYT0TGpsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTBwMEWwNFMh|ryP NYLENZFxW0GQR1XS
IMR-5 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmr4TWM2OD1yLkC1NFIyKM7:TR?= M4jIT3NCVkeHUh?=
TE-5 NHnIbFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTxTWM2OD1yLkC1NFY{KM7:TR?= NVjmWFh{W0GQR1XS
DJM-1 NGG5eGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\OOWNKSzVyPUCuNFUyPDJizszN MnjrV2FPT0WU
NB17 NVvhWHpPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPQc5lpUUN3ME2wMlA2OjB5IN88US=> M3X1N3NCVkeHUh?=
KARPAS-45 NVvYNJRNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmP5TWM2OD1yLkC1N|U5KM7:TR?= NHqyS45USU6JRWK=
TGBC1TKB M2DPNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwMEW0NFUh|ryP M1u2TXNCVkeHUh?=
ML-2 NV3KcJBCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fib2lEPTB;MD6wOVQyPCEQvF2= NVzr[GVCW0GQR1XS
no-10 NEi3c3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWG0ZpBEUUN3ME2wMlA2PDd2IN88US=> NGi0O4VUSU6JRWK=
CTV-1 NX7MUFZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPaTWM2OD1yLkC1OVAzKM7:TR?= MoLEV2FPT0WU
SJSA-1 MkjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHmeWhKSzVyPUCuNFU2OiEQvF2= MVjTRW5ITVJ?
HC-1 NX:1OolVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfvOI5KSzVyPUCuNFU2QTdizszN NIL4R3VUSU6JRWK=
TE-12 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTBwMEW2NVMh|ryP NH:1UIpUSU6JRWK=
KY821 MnzyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIf4NpZKSzVyPUCuNFU3OzJizszN NX7ONotPW0GQR1XS
TALL-1 NWTiWJNwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M170V2lEPTB;MD6wOVcxQCEQvF2= NIjTTGtUSU6JRWK=
DEL MkSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HjfGlEPTB;MD6wOVcxQSEQvF2= MontV2FPT0WU
TE-6 NGTmXpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLITWM2OD1yLkC1O|IzKM7:TR?= M36wcnNCVkeHUh?=
SK-LMS-1 MkHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XQWGlEPTB;MD6wOVgxPSEQvF2= NGnFUoFUSU6JRWK=
EW-1 M4rldmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPGZZlKSzVyPUCuNFU5OzdizszN NWXDbFI2W0GQR1XS
8-MG-BA Mo\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTM[nJzUUN3ME2wMlA2QDVzIN88US=> NXjjRpNDW0GQR1XS
NALM-6 NInVdG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTBwMEW5O|Mh|ryP NXPpN2VmW0GQR1XS
LB771-HNC MnnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknJTWM2OD1yLkC1PVc6KM7:TR?= Mn7hV2FPT0WU
HT-144 MoL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nIO2lEPTB;MD6wOlE{KM7:TR?= M2nKSHNCVkeHUh?=
KM-H2 Mlj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwME[yNlEh|ryP NGnnOWlUSU6JRWK=
SF268 NHrvSoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTBwME[yPFYh|ryP NVy0Z4ZYW0GQR1XS
RS4-11 NV31d2g3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTnTWM2OD1yLkC2N|A1KM7:TR?= NX;Wd|RmW0GQR1XS
MHH-PREB-1 M1LFS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILYTGhKSzVyPUCuNFY{OTlizszN NGfueXNUSU6JRWK=
ATN-1 MmrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTBwME[zOFUh|ryP M3fnTHNCVkeHUh?=
BB30-HNC MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrjTnBjUUN3ME2wMlA3PDN4IN88US=> MlKwV2FPT0WU
CPC-N MljRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTBwME[1NlQh|ryP MULTRW5ITVJ?
NB1 MnPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\6dmpKSzVyPUCuNFY3OTNizszN M1HvOXNCVkeHUh?=
KS-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXwXnBHUUN3ME2wMlA3PzR6IN88US=> M3zYeHNCVkeHUh?=
RXF393 NUPyfWtST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYG3NmlGUUN3ME2wMlA3PzZ2IN88US=> Ml;YV2FPT0WU
IST-SL2 M1vlSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHQO|JKSzVyPUCuNFcxODRizszN Mke1V2FPT0WU
GI-ME-N NH\mfIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HNemlEPTB;MD6wO|I5PiEQvF2= Mnf1V2FPT0WU
VA-ES-BJ NI\jNVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIL3[G9KSzVyPUCuNFc1PzVizszN MWnTRW5ITVJ?
NCI-H1581 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLvUXpKSzVyPUCuNFc1PzhizszN NFK1T2VUSU6JRWK=
U-266 NH7mS5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vYVGlEPTB;MD6wO|Q6PyEQvF2= M1TzNnNCVkeHUh?=
DMS-114 NHvHSmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwMEe1Nlgh|ryP NG\4cINUSU6JRWK=
NCI-H187 M2HMT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHsNJZVUUN3ME2wMlA4PzJ4IN88US=> M1G4RXNCVkeHUh?=
SW962 MmrUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzCblhKSzVyPUCuNFc5OzlizszN MkPOV2FPT0WU
MONO-MAC-6 MlHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TxSmlEPTB;MD6wO|k5PiEQvF2= MnG5V2FPT0WU
MOLT-16 NHPoUlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwMEixNlEh|ryP NILhTYtUSU6JRWK=
KNS-42 M1XtTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXJPWVKSzVyPUCuNFgyPjFizszN NG\1XppUSU6JRWK=
CMK Mne1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTBwMEiyNlUh|ryP MmPKV2FPT0WU
Ramos-2G6-4C10 NY[2[ZpET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXhR|c4UUN3ME2wMlA5OjJ3IN88US=> M1riNXNCVkeHUh?=
Daudi Mn\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF71XGNKSzVyPUCuNFgzPTZizszN MYPTRW5ITVJ?
NCI-H510A M1HCT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml20TWM2OD1yLkC4N|M3KM7:TR?= NIfmfIdUSU6JRWK=
LB831-BLC NHz1[|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnpTWM2OD1yLkC4OVYyKM7:TR?= MkLLV2FPT0WU
HEL NUXaNIhJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLRTWM2OD1yLkC4OlY5KM7:TR?= MXzTRW5ITVJ?
LU-134-A MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\DRZNoUUN3ME2wMlA5PzB6IN88US=> MWjTRW5ITVJ?
NCI-H1694 Mom5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4O3[WlEPTB;MD6wPFc1PCEQvF2= MWnTRW5ITVJ?
KGN NInkbnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHGw[XVKSzVyPUCuNFg4PTlizszN NUXVVlU1W0GQR1XS
A253 Ml7HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml:3TWM2OD1yLkC4PFIzKM7:TR?= NXTiWml7W0GQR1XS
DG-75 NX2zU3NbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTBwMEi5NlIh|ryP M4PxdXNCVkeHUh?=
MOLT-4 Mn\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1qycWlEPTB;MD6wPFk5OyEQvF2= MWTTRW5ITVJ?
NCI-SNU-5 NVqwd|FET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTmTWM2OD1yLkC5NlU5KM7:TR?= Ml7wV2FPT0WU
ONS-76 MlfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjHfIVzUUN3ME2wMlA6Ojd4IN88US=> NWDOe401W0GQR1XS
NCI-H446 Mof4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvrTWM2OD1yLkC5OFYzKM7:TR?= Ml23V2FPT0WU
COR-L279 NUjTfIplT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTBwMEm1OVYh|ryP MnLoV2FPT0WU
Calu-6 NEDDOldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmP4TWM2OD1yLkC5OVk5KM7:TR?= NVHkVFZmW0GQR1XS
BC-3 NVjPbFBQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LsSGlEPTB;MD6wPVY3OiEQvF2= M2PYWHNCVkeHUh?=
NCI-H2126 MkC5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnpOmhKSzVyPUCuNFk4QTFizszN MWnTRW5ITVJ?
NCI-H1882 MlTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwMEm4NFkh|ryP MmHRV2FPT0WU
BB65-RCC MoHkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moq1TWM2OD1yLkGwNlk1KM7:TR?= M13VdXNCVkeHUh?=
DU-4475 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\mRnFXUUN3ME2wMlExPDB5IN88US=> NEnMeGRUSU6JRWK=
NCI-H526 NGS3bZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnz3TWM2OD1yLkGwOFQh|ryP NFqzco9USU6JRWK=
NEC8 M1THXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTBwMUC1NlUh|ryP MmLQV2FPT0WU
NCI-H1304 NILBdpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjDTWM2OD1yLkGwOVk1KM7:TR?= M2[xPXNCVkeHUh?=
L-540 MnjmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fUR2lEPTB;MD6xNFcxQCEQvF2= NFLrdYlUSU6JRWK=
NCI-SNU-16 Mm[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoToTWM2OD1yLkGwO|QzKM7:TR?= Mn7wV2FPT0WU
HD-MY-Z NX;xWFR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwMUC4OVYh|ryP MmXtV2FPT0WU
K-562 NEf0c5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwMUC4OVgh|ryP Mlm4V2FPT0WU
JAR NWrvepJiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;6d2lEPTB;MD6xNFkzPSEQvF2= MoK2V2FPT0WU
MZ2-MEL M4nybmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{i2[2lEPTB;MD6xNVA2KM7:TR?= MkXmV2FPT0WU
L-363 M2PPSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3JdIl3UUN3ME2wMlEyODd7IN88US=> MYHTRW5ITVJ?
BV-173 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoL2TWM2OD1yLkGxNlQ{KM7:TR?= MmnEV2FPT0WU
NCI-H524 NWDOWpdFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vSb2lEPTB;MD6xNVI4PCEQvF2= Moj5V2FPT0WU
EoL-1-cell NEjkXWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTBwMUG2O|Ih|ryP Mor2V2FPT0WU
K052 M1Xjcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nURmlEPTB;MD6xNVcyOiEQvF2= M2fFVXNCVkeHUh?=
TK10 M4qzOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwMUG3Nlgh|ryP M{DRXnNCVkeHUh?=
KU812 M3LnO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTBwMUKwOFQh|ryP NGfPSZNUSU6JRWK=
RPMI-8226 Ml;TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLyTWM2OD1yLkGyNFUzKM7:TR?= M1fK[nNCVkeHUh?=
MZ7-mel NEfsSpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3L0ZWlEPTB;MD6xNlI{PyEQvF2= NYrIWo1UW0GQR1XS
SK-PN-DW NFzqS3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwMUKyPFch|ryP MV;TRW5ITVJ?
SR NXrFUWJMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofoTWM2OD1yLkGyOFQyKM7:TR?= NUDxV5pMW0GQR1XS
RPMI-6666 MmfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTBwMUK3OFMh|ryP NUTxeHRuW0GQR1XS
no-11 NGHPeXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjFfVFMUUN3ME2wMlEzQDZ7IN88US=> MU\TRW5ITVJ?
EW-3 MkTKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnPTWM2OD1yLkGyPFk{KM7:TR?= NFjQT|VUSU6JRWK=
LAMA-84 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvHb3JKSzVyPUCuNVMyQDdizszN Mk\5V2FPT0WU
HT MnvOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHi4cGdKSzVyPUCuNVM2PzRizszN MoPPV2FPT0WU
KP-N-RT-BM-1 NEnoVmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TEVGlEPTB;MD6xN|YyOiEQvF2= NI\kTGFUSU6JRWK=
NCI-H747 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;0d|lKSzVyPUCuNVM4KM7:TR?= M1WycXNCVkeHUh?=
NCCIT MoTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4L2fWlEPTB;MD6xN|k{QSEQvF2= MUfTRW5ITVJ?
MLMA NXHx[FA2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwMUSxOlch|ryP NF3NSpdUSU6JRWK=
LP-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnBelFoUUN3ME2wMlE1OjRizszN NXK3S|JLW0GQR1XS
CAL-148 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTNTWM2OD1yLkG0OFg{KM7:TR?= MYLTRW5ITVJ?
GB-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXpd|BuUUN3ME2wMlE1PTJ4IN88US=> M{TaTHNCVkeHUh?=
COR-L88 Mn7rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XPUWlEPTB;MD6xOFgxOiEQvF2= M1PBVXNCVkeHUh?=
NKM-1 M4DRSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwMUS5NFYh|ryP M1GzcXNCVkeHUh?=
NB5 NF7hWINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE[3bFZKSzVyPUCuNVU1PjJizszN NXvJfVVRW0GQR1XS
SH-4 MkTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7zTWM2OD1yLkG1OFY3KM7:TR?= MmS5V2FPT0WU
EM-2 NHPNV5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTyTWM2OD1yLkG1OFY4KM7:TR?= NFX3fpRUSU6JRWK=
TGBC24TKB MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInlPGVKSzVyPUCuNVU3PTlizszN Mme5V2FPT0WU
SCLC-21H NGDX[|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXIZo5YUUN3ME2wMlE2PzB{IN88US=> NF;QN5dUSU6JRWK=
COLO-684 NEHpWG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlG0TWM2OD1yLkG1O|IyKM7:TR?= NFXjdZNUSU6JRWK=
KINGS-1 MnTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1u1c2lEPTB;MD6xOVkyKM7:TR?= MXfTRW5ITVJ?
LS-123 NGPF[3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\0OmlEPTB;MD6xOVkyPyEQvF2= NGL4SJRUSU6JRWK=
MC116 Mn[3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEW1eXZKSzVyPUCuNVYyPThizszN MUXTRW5ITVJ?
SU-DHL-1 NWLHbY9LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2W1[mlEPTB;MD6xOlIxPiEQvF2= NHzxSZVUSU6JRWK=
NCI-H64 NGjxW|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTBwMU[zOFch|ryP Mm\wV2FPT0WU
HCE-T NYDGWm4xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;4UGM4UUN3ME2wMlE3PTB2IN88US=> MkDlV2FPT0WU
LOXIMVI MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFe1[45KSzVyPUCuNVY6PDlizszN M2DYS3NCVkeHUh?=
ARH-77 NIDyOFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\nTWM2OD1yLkG3N|c6KM7:TR?= MUTTRW5ITVJ?
DOHH-2 MnXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\ITGtVUUN3ME2wMlE4Pjd{IN88US=> NFvM[41USU6JRWK=
COLO-320-HSR M4HP[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DUfGlEPTB;MD6xPFE2PCEQvF2= NVHzRYV2W0GQR1XS
NB6 MnfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInjdnJKSzVyPUCuNVg2PjZizszN MWPTRW5ITVJ?
L-428 MmjaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDkTWM2OD1yLkG4PFE{KM7:TR?= MVvTRW5ITVJ?
SNB75 MlLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTBwMUi4NlQh|ryP Mln6V2FPT0WU
NCI-H2141 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWf3b|RwUUN3ME2wMlE6ODFzIN88US=> MYjTRW5ITVJ?
KARPAS-299 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwMUmyOFEh|ryP MULTRW5ITVJ?
LC4-1 NGPleXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\qTWM2OD1yLkG5OVAzKM7:TR?= MXLTRW5ITVJ?
UACC-257 MlvuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTBwMUm5OFch|ryP M4\XS3NCVkeHUh?=
EVSA-T NH;hb|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwMkCzNVIh|ryP M4LrNHNCVkeHUh?=
JiyoyeP-2003 MmrXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXXdpBKSzVyPUCuNlA1PzdizszN M4rvcnNCVkeHUh?=
NCI-H720 M3HwWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTBwMkC1NlUh|ryP M4nJbXNCVkeHUh?=
GAK NXXGZ2JwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTBwMkGxPFkh|ryP NVu1bFVjW0GQR1XS
HH NXn6VVg2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rvdWlEPTB;MD6yNVQxPSEQvF2= M2LCcHNCVkeHUh?=
NCI-H1436 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLKTWM2OD1yLkKxOFY1KM7:TR?= MXvTRW5ITVJ?
GR-ST MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETTSmRKSzVyPUCuNlE1QDhizszN NUjNXIJLW0GQR1XS
BC-1 NHvWOHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4q4dmlEPTB;MD6yNlYyPiEQvF2= M1[4[XNCVkeHUh?=
SIG-M5 NWDzcolyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17sOGlEPTB;MD6yNlczPyEQvF2= NFvjenFUSU6JRWK=
NCI-H345 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzBTWM2OD1yLkKzPFA2KM7:TR?= NXXKNWRXW0GQR1XS
OPM-2 NGLsbmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\G[2lEPTB;MD6yN|g5OiEQvF2= MW\TRW5ITVJ?
LB1047-RCC MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1G3OWlEPTB;MD6yOFQyKM7:TR?= NWfKWZFHW0GQR1XS
CTB-1 NHzoRnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDKZWdKSzVyPUCuNlQ1QTNizszN MnnkV2FPT0WU
A3-KAW Ml[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjrTWM2OD1yLkK1N|QyKM7:TR?= NV24coZkW0GQR1XS
SF126 M4fNXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfzdINKSzVyPUCuNlU{QDNizszN NITUcpBUSU6JRWK=
KARPAS-422 NIfNcItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTBwMkW0N|Uh|ryP MVvTRW5ITVJ?
MEG-01 M3rPeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwMkW2O|Mh|ryP M1HBSXNCVkeHUh?=
NCI-H209 Mkn2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXhWXBGUUN3ME2wMlI3Ozd2IN88US=> NVu1enhGW0GQR1XS
SBC-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDETWM2OD1yLkK2OUDPxE1? MXPTRW5ITVJ?
K5 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\3Oo1KSzVyPUCuNlY6QDRizszN NHu0b4dUSU6JRWK=
QIMR-WIL M33aW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLoVYNKSzVyPUCuNlcyPTVizszN MWfTRW5ITVJ?
NMC-G1 NEWzO3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;aTWM2OD1yLkK4NlE4KM7:TR?= NFThcI1USU6JRWK=
IST-MES1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHFeIdKSzVyPUCuNlkzOzhizszN MWXTRW5ITVJ?
SW684 NELqW5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\VeWlEPTB;MD6zNFA1PyEQvF2= MVPTRW5ITVJ?
MV-4-11 NXXVNGJUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHMOYNIUUN3ME2wMlMxPzh6IN88US=> NH7zcJlUSU6JRWK=
LAN-6 M4PTSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPJeVZKSzVyPUCuN|E2PzJizszN M3XYV3NCVkeHUh?=
RH-1 M{TPN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLOTWM2OD1yLkOxPFcyKM7:TR?= M1v3UXNCVkeHUh?=
CP66-MEL M1HOWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\SUmlEPTB;MD6zNVg4QCEQvF2= MnP4V2FPT0WU
EC-GI-10 M1m4fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzsZW5KSzVyPUCuN|I6QDdizszN NVzmRWZkW0GQR1XS
GDM-1 MkfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTXN21NUUN3ME2wMlM{ODV7IN88US=> NWC4PYk4W0GQR1XS
IST-SL1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mli5TWM2OD1yLkO0PVE1KM7:TR?= MmTUV2FPT0WU
KMOE-2 NHfRb2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PL[mlEPTB;MD6zOVE4PSEQvF2= NV3vfXF6W0GQR1XS
OS-RC-2 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfZ[Iw5UUN3ME2wMlM2PTR2IN88US=> MoH3V2FPT0WU
HDLM-2 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml23TWM2OD1yLkO3PFE1KM7:TR?= MmDuV2FPT0WU
DSH1 NV3X[XpUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LPcGlEPTB;MD6zPFY{OSEQvF2= MoDFV2FPT0WU
LS-1034 MlXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3oTWM2OD1yLkO4PVU1KM7:TR?= NH\B[lJUSU6JRWK=
LB373-MEL-D MnLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\zVHNbUUN3ME2wMlM6OTl5IN88US=> NXzWVINOW0GQR1XS
GOTO NFvuOWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2D1[WlEPTB;MD60NlEyQCEQvF2= Ml\RV2FPT0WU
MRK-nu-1 NUjyVYZ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTBwNEKyNFUh|ryP NHiwVVlUSU6JRWK=
SK-MM-2 NUK3fXZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFm4fZRKSzVyPUCuOFM1PDJizszN NFXxUHdUSU6JRWK=
BOKU M3\0Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrVdohKSzVyPUCuOFM4QTJizszN MXjTRW5ITVJ?
NOMO-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVGxdGt2UUN3ME2wMlQ{QDZizszN M4\0[nNCVkeHUh?=
J-RT3-T3-5 M3v1NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPQRWlKSzVyPUCuOFQ5PzhizszN MnXUV2FPT0WU
COLO-668 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoewTWM2OD1yLkS1OlY5KM7:TR?= NWjnSFJYW0GQR1XS
SF539 NGGzZWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfVO5NKSzVyPUCuOFg3QDRizszN NGjCZmRUSU6JRWK=
LB2518-MEL NELTVZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\LbnloUUN3ME2wMlQ6PzB|IN88US=> M4jKNHNCVkeHUh?=
TE-441-T MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwNUCxNkDPxE1? MV;TRW5ITVJ?
MDA-MB-134-VI NX;HcHU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTQV3VKSzVyPUCuOVA6OjFizszN MoLkV2FPT0WU
SCC-3 M1;Cd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnlZ2lnUUN3ME2wMlUyQDd|IN88US=> MYnTRW5ITVJ?
KLE MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTBwNUKxO|Eh|ryP M3TieHNCVkeHUh?=
LB2241-RCC NH7mbXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2f0eGlEPTB;MD61NlUzPSEQvF2= MYLTRW5ITVJ?
NCI-H1417 MojoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDOTWM2OD1yLkWzOFM2KM7:TR?= M1;MeXNCVkeHUh?=
NCI-H2081 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHUOZNVUUN3ME2wMlU5PjFzIN88US=> NELqeIhUSU6JRWK=
NCI-H1522 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwNUmzPFMh|ryP MknyV2FPT0WU
NCI-H889 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTBwNUm4OFQh|ryP NHfqV4tUSU6JRWK=
CGTH-W-1 M3XmRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLSeI9KSzVyPUCuOlA4PTVizszN MYPTRW5ITVJ?
EB-3 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTBwNkGxOVMh|ryP NXjHd4JqW0GQR1XS
D-336MG NXv1VmNkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPVbYZKSzVyPUCuOlE4QTFizszN NVqzOIsxW0GQR1XS
LC-1F M1vDeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwNkK1PVIh|ryP Mn33V2FPT0WU
MHH-NB-11 NUPCVVltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwNkO4NFEh|ryP M4DjXHNCVkeHUh?=
SK-N-FI M4i4W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwNkO5NUDPxE1? NU\DdIc{W0GQR1XS
NCI-H69 MnPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmqwTWM2OD1yLk[0PFc6KM7:TR?= NHPzOIRUSU6JRWK=
SCH MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDhS3pKSzVyPUCuOlYxOjNizszN MmHnV2FPT0WU
LS-513 Mk\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTBwNkeyOVkh|ryP NXOxUZA2W0GQR1XS
CP67-MEL NH[1cohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzJcolKUUN3ME2wMlY4PTl4IN88US=> NVHLUmdkW0GQR1XS
GCIY MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF62SXFKSzVyPUCuO|A{PjNizszN NXe0N5BjW0GQR1XS
SHP-77 M1;6OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\tVZY4UUN3ME2wMlcxPzN2IN88US=> M1ricHNCVkeHUh?=
EHEB NXToU4xOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TWUWlEPTB;MD63NVg2PCEQvF2= MkDHV2FPT0WU
D-247MG M4DQZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NED1ZnZKSzVyPUCuO|MzOzJizszN M1G1V3NCVkeHUh?=
Raji Mn:0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwN{S5PFkh|ryP MVTTRW5ITVJ?
MPP-89 MkK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTBwN{W5O|gh|ryP M2rrOnNCVkeHUh?=
EKVX NUHXe256T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwN{mwO|Mh|ryP NXLvXXV[W0GQR1XS
HCC2218 M2rMTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofvTWM2OD1yLke5NVMyKM7:TR?= M2DZUHNCVkeHUh?=
KNS-81-FD NHPITVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3oTWM2OD1yLkixNFEyKM7:TR?= NUHrbHVMW0GQR1XS
HCC2157 NUe2WZY3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17tOmlEPTB;MD64OFk2OSEQvF2= M1;YNnNCVkeHUh?=
BT-474 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlG1TWM2OD1yLki4PFU1KM7:TR?= MmDhV2FPT0WU
NCI-H748 MofMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwOUGyJO69VQ>? MkexV2FPT0WU
EW-24 Ml60S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTBwOUKwNFIh|ryP MV3TRW5ITVJ?
D-263MG MknuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrMfJRSUUN3ME2wMlk1PTF{IN88US=> NXzQXnJzW0GQR1XS
OMC-1 Mk\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXiwZm91UUN3ME2wMlk3Ozd|IN88US=> NYTlSotLW0GQR1XS
NCI-H2196 M1\jfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwOUe3O|ch|ryP NYTsfmROW0GQR1XS
HAL-01 NYe5[ZJDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPiUG9LUUN3ME2wMlk6QDd{IN88US=> NHT5NldUSU6JRWK=
NCI-H2107 NUDYfHl7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LyWmlEPTB;MT6wNVg2PCEQvF2= NFPQVoRUSU6JRWK=
LB996-RCC MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvBTWM2OD1zLkC4NFUyKM7:TR?= NGflXJpUSU6JRWK=
NCI-H1395 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4GwRWlEPTB;MT6xNFY4KM7:TR?= NW\vS5djW0GQR1XS
CHP-126 NXHwVJVMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTFwMU[xPVkh|ryP NV7tSVM1W0GQR1XS
NB69 NUn6VYJtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DId2lEPTB;MT6yOlE1QCEQvF2= NV7jfHlXW0GQR1XS
CAS-1 NEH1Nm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXGzeFJiUUN3ME2xMlM1OjNzIN88US=> NWPHOJVNW0GQR1XS
JVM-3 MlzvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfOUXZHUUN3ME2xMlQ4QDV3IN88US=> NVXZOZVqW0GQR1XS
DMS-153 NWXy[ZA2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLIXY5kUUN3ME2xMlU4Pjd2IN88US=> NEXGNJpUSU6JRWK=
SK-MEL-2 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHqTWM2OD1zLkexO|g6KM7:TR?= NITQeXBUSU6JRWK=
NCI-H1155 NI[yZYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfLdJdKSzVyPUGuO|M3PzZizszN NEnFN5hUSU6JRWK=
NCI-H1092 MnLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnJV3dWUUN3ME2xMlc3OTh{IN88US=> MXvTRW5ITVJ?
LU-165 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjyTWM2OD1zLki2OFc3KM7:TR?= M4TkPHNCVkeHUh?=
HL-60 M1u4fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYezRo9xUUN3ME2xMlk6QTB6IN88US=> MlH6V2FPT0WU
REH MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\vTWM2OD1{LkCwOVgzKM7:TR?= MVfTRW5ITVJ?
JVM-2 M1T6XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{L0bWlEPTB;Mj6wOlE{PSEQvF2= NGX1eHdUSU6JRWK=
MN-60 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTJwMUezNFgh|ryP MkPGV2FPT0WU
SCC-15 MlLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTJwMkCyO{DPxE1? M4rEbnNCVkeHUh?=
SNU-C1 Ml3VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrVSYFKSzVyPUKuNlE{PDNizszN NFLwcY5USU6JRWK=
SK-MEL-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTVNWRQUUN3ME2yMlMzODR5IN88US=> MmTlV2FPT0WU
TGW M3PQXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfVXFRKSzVyPUKuN|UxOjdizszN Ml[yV2FPT0WU
CA46 MljKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTJwN{W5Olch|ryP M3j0XnNCVkeHUh?=
NCI-H23 MnvrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfsTWM2OD1{LkiwO|kyKM7:TR?= NYLKcGRbW0GQR1XS
MMAC-SF NHi2TmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPmRVZ{UUN3ME2yMlg3PjJ6IN88US=> MWjTRW5ITVJ?
NCI-H2171 MnzwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rCcmlEPTB;Mz6wN|Q1QCEQvF2= NGfmTGtUSU6JRWK=
A704 NXXYNINZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYCyT4s{UUN3ME2zMlE1OTl2IN88US=> MUjTRW5ITVJ?
DB NYq1d4tYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3i3NmlEPTB;Mz6yOVU4PiEQvF2= M2XrfnNCVkeHUh?=
NCI-H719 M3PjOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkC2TWM2OD1|LkOwN|g1KM7:TR?= NWHCZ29UW0GQR1XS
MC-CAR MnrGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPBc4VKSzVyPUOuOVQ5OTdizszN M4HxZnNCVkeHUh?=
SIMA MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;GUVNoUUN3ME2zMlU5PDF4IN88US=> M2H2eXNCVkeHUh?=
SW872 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\NNnVIUUN3ME2zMlc5OTBzIN88US=> NUTJRVZqW0GQR1XS
HCC1187 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlK3TWM2OD1|Lke4N|E2KM7:TR?= NHLxdJJUSU6JRWK=
EW-13 NIfu[ppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3ftVWlEPTB;Mz64N|QyPyEQvF2= NXizRo0yW0GQR1XS
NCI-SNU-1 NFnm[JpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoP2TWM2OD12LkKxPVk6KM7:TR?= NW\y[otpW0GQR1XS
NCI-H226 MmC5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfWTllEUUN3ME20MlM{PjB4IN88US=> NIjYd|RUSU6JRWK=
RPMI-8866 NFvzPFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTRwM{[wNlkh|ryP MXnTRW5ITVJ?
OCI-AML2 NEexPFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVT4eIJSUUN3ME20MlU2OjNizszN NVv4WXZiW0GQR1XS
LU-65 M3XZV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3QTWM2OD12LkmzNFM{KM7:TR?= MWXTRW5ITVJ?
SK-N-DZ NYnIUpp5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfZRWg1UUN3ME21MlY{PDZ3IN88US=> M2\3O3NCVkeHUh?=
NB14 MnvDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYWxTno1UUN3ME21Mlk4OTN3IN88US=> NE\KSo9USU6JRWK=
COLO-829 MmfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPMTWM2OD14LkOzN|U6KM7:TR?= NUPWWXB4W0GQR1XS
MHH-CALL-2 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3MclNEUUN3ME22MlUyPTB6IN88US=> MnjmV2FPT0WU
NCI-H1770 NWH0O2hKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\PPXo5UUN3ME22MlY3QTB2IN88US=> NY\FZ4pUW0GQR1XS
ECC4 NYrkXI4{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH33XJZKSzVyPU[uPFIyPzlizszN M{S1RXNCVkeHUh?=
A498 NG\Ie4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnr0TWM2OD14Lki3NVkzKM7:TR?= MW\TRW5ITVJ?
DMS-79 M3[3Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPPTYVnUUN3ME23MlA1PTF{IN88US=> M4rTbnNCVkeHUh?=
P30-OHK MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmflTWM2OD15LkKxPVA3KM7:TR?= MnXkV2FPT0WU
D-502MG NVfDd4tNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfpRWRKSzVyPUeuPVg{PiEQvF2= NGDaZplUSU6JRWK=
RCC10RGB NXHoUnpJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\ydGtKSzVyPUiuNFYzQCEQvF2= NILqenBUSU6JRWK=
U-698-M M4j4XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITEd|dKSzVyPUiuNlkzOjZizszN NYfaU4hNW0GQR1XS
BB49-HNC M4nmWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTlwNEKyOlUh|ryP NHjCTppUSU6JRWK=
ES1 NEfFd3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPUTWM2OD17Lk[4PVU3KM7:TR?= M{TkcXNCVkeHUh?=
MFM-223 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfXT|M1UUN3ME2xNE46QTJ5IN88US=> MlzkV2FPT0WU
C2BBe1 MoL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrmboVWUUN3ME2xNU4{PTJ|IN88US=> NGTxdnVUSU6JRWK=
EB2 Mkm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvxWVlKSzVyPUGyMlY5QDFizszN M36xZ3NCVkeHUh?=
C8166 M1fHS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHHTWM2OD1zMz64N|A{KM7:TR?= MWTTRW5ITVJ?
ES3 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTF|Lkm5O|ch|ryP NUHmdVVuW0GQR1XS
NCI-H1650 MlTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LoV2lEPTB;MU[uN|c3PSEQvF2= M37EXXNCVkeHUh?=
Mo-T M{DnXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HKNGlEPTB;MUeuOFAzQSEQvF2= MonWV2FPT0WU
NB7 M{L4ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2mxOWlEPTB;MUeuO|Q3PyEQvF2= MWDTRW5ITVJ?
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HCT116p53(-/-) NYrVcpVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUCxNE0yODByIH7N MX[yOE81QCCq NU\SUppQcW6qaXLpeJMh[2WubDDwdo9tcW[ncnH0bY9vKGOxbYDs[ZRmdHliYYSgNlUhdk1? MVSyNlI3OjF5MR?=
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HeLa  M1zkTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWixNE0yODBibl2= Mn;vO|IhcA>? NHnNb2FFVVOR NX\MZnJlUUN3ME21NE42KG6P NG\KRZEzOjB6MEKzOS=>
GBC NH3FV4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV[3NkBp NITKSWtKSzVyPUG0Mlc5KG6P MmjHNlE6PjV5M{m=
GB-CL-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLaO|IhcA>? MkLRTWM2OD13LkKyJI5O M2\XT|IyQTZ3N{O5
Mz-ChA-2 NUC0[m9qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LRfFczKGh? Mn[zTWM2OD1|LkOxJI5O NVjjdmhiOjF7NkW3N|k>
TGBC1-TKB NFi2cWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2qyblE1PCCq MoXyTWM2OD14LkeyJI5O MV6yNVk3PTd|OR?=
Wittier MmHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvXO|IhcA>? MkTNTWM2OD1|LkK2JI5O M4jBdFIyQTZ3N{O5
H-1 NFTNUY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX36PWR5PzJiaB?= M4HWfWlEPTB;OT61OEBvVQ>? MVOyNVk3PTd|OR?=
HuH-28 MlfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;QemR2PzJiaB?= NWHrVVZEUUN3ME2xNU4yQSCwTR?= M4S4PFIyQTZ3N{O5
NEC NH;CZWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvXO|IhcA>? M2q0WWlEPTB;OT65PEBvVQ>? M4f0SFIyQTZ3N{O5
REB MmrKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFO5S|I4OiCq MUnJR|UxRTF|LkWxJI5O MYWyNVk3PTd|OR?=
CC-LP-1 NHfOfVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;ndoZSPzJiaB?= MV3JR|UxRTVwOESgcm0> NHHPc|AzOTl4NUezPS=>
CC-SW-1 NFnHdFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M322bFczKGh? MVHJR|UxRTlwNUWgcm0> MlTrNlE6PjV5M{m=
EGI-1 M4rue2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrUNmNXPzJiaB?= NYK5V3U4UUN3ME2xNE44OiCwTR?= MVKyNVk3PTd|OR?=
Sk-ChA-1 MlrxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDWVYw4OiCq M4DiTWlEPTB;MUeuNkBvVQ>? NYrONmFiOjF7NkW3N|k>
TFK-1 NY\4dYdKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nqNVczKGh? NEnTdIpKSzVyPUGzMlQ2KG6P MXWyNVk3PTd|OR?=
786-O NWnCOFcxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWG1MVgxKG6P MlThPVYhcA>? NXjLflRQUEOu MYfzeZBxemW|c3XzJJRp\SCycn;sbYZmemG2aX;uJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXyJJdqfGhiSVO1NOKhfmGudXXzJI9nKDJidH:gNlAhdk1? M17xcVIyPjR{M{e0
A498 NFXMbpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnKOlVGPS16MDDuUS=> MnnqPVYhcA>? NIrW[21JS2x? NEXz[3Z{fXCycnXzd4V{KHSqZTDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVzKHerdHigTWM2OMLidnHseYV{KG:oIEKgeI8hOjBibl2= MmCwNlE3PDJ|N{S=
ACHN M2\rNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXS1MVgxKG6P NH3L[no6PiCq NU\5c5V5UEOu Moq3d5VxeHKnc4Pld{B1cGVicILvcIln\XKjdHnvckBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldkB4cXSqIFnDOVDDqH[jbIXld{Bw\iB{IITvJFIxKG6P NGP1XoozOTZ2MkO3OC=>
Caki-1 M2LaTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTofo1vPS16MDDuUS=> M3X6b|k3KGh? MUPIR4w> MWfzeZBxemW|c3XzJJRp\SCycn;sbYZmemG2aX;uJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXyJJdqfGhiSVO1NOKhfmGudXXzJI9nKDJidH:gNlAhdk1? NFnHfokzOTZ2MkO3OC=>
SN12C NXTRR4lnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVW1MVgxKG6P MlTaPVYhcA>? M3yyVGhEdA>? MY\zeZBxemW|c3XzJJRp\SCycn;sbYZmemG2aX;uJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXyJJdqfGhiSVO1NOKhfmGudXXzJI9nKDJidH:gNlAhdk1? MYKyNVY1OjN5NB?=
HMC-1.1 Mkm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWexMVExODBibl2= MX:3NkBp NH:0epZqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmV? MVOyNVI1OjF6OR?=
HMC-1.2 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTINU0yODByIH7N NXfPUJhwPzJiaB?= MojhbY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5m MYeyNVI1OjF6OR?=
C2 NVPlTIJKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWmxMVExODBibl2= NFvkNWc4OiCq MXnpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoU> NUjwXlFROjF{NEKxPFk>
CHP-212 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;UZ44yNTF{NTDuUS=> Ml3ONlQuOTJyIHi= NYKyRnJLcW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBjd3SqIITpcYUuKGGwZDDkc5NmNWSncHXu[IVvfCCvYX7u[S=> Ml;HNlEyPjl{NEK=
IMR-32 NXjBb5M6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7UNU0yOjVibl2= Mo[5NlQuOTJyIHi= NV[xNmJRcW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBjd3SqIITpcYUuKGGwZDDkc5NmNWSncHXu[IVvfCCvYX7u[S=> MW[yNVE3QTJ2Mh?=
Kelly NYjDOIRMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLDfnhsOS1zMkWgcm0> MXSyOE0yOjBiaB?= MkS1bY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= MVKyNVE3QTJ2Mh?=
SH-EP M{PDSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTIVIFXOS1zMkWgcm0> M3uw[FI1NTF{MDDo NWPR[|BicW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBjd3SqIITpcYUuKGGwZDDkc5NmNWSncHXu[IVvfCCvYX7u[S=> MVOyNVE3QTJ2Mh?=
SH-SY5Y Mmi2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWCxMVEzPSCwTR?= NIqwcG0zPC1zMkCgbC=> NGPQdFFqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l MX[yNVE3QTJ2Mh?=
SK-N-AS MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HTOVEuOTJ3IH7N M4\tNVI1NTF{MDDo M3;RbYlvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZo91cCC2aX3lMUBidmRiZH;z[U1l\XCnbnTlcpQhdWGwbnW= MV2yNVE3QTJ2Mh?=
SK-N-BE NYnCdIJMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPDNU0yOjVibl2= NHjHUIEzPC1zMkCgbC=> Mn\ibY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= MX:yNVE3QTJ2Mh?=
KG1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjUTZEyNzFyL{GwNEBvVQ>? NF3yepQ4OiCq MVLEUXNQ MX;pcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n NF7S[IkyQTR3OEO1PC=>
U937 NVzmNIE4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\tNU8yOC9zMECgcm0> M1POZlczKGh? NG[5THpFVVOR NH7MbVBqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l NH3kcVUyQTR3OEO1PC=>
CAL62 NHHRW2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUGwMlEuOTByIH7N MWm3NkBp M4nSNGROW09? Mn;FSWM2OD1zLkSgcm0> NH6x[4YyQTJ{M{W1Ny=>
OCUT-1 MlvGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;JV|AvOS1zMECgcm0> MVu3NkBp M2G0cGROW09? MXvFR|UxRTJwMzDuUS=> NH7vS3YyQTJ{M{W1Ny=>
8505C MkH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvJO4ExNjFvMUCwJI5O MVm3NkBp NFrKXmtFVVOR NUm0Ro5xTUN3ME2zMlIhdk1? MmHaNVkzOjN3NUO=
ACT-1 NFnafYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnocJMzOC5zLUGwNEBvVQ>? MXG3NkBp NVTVN4R3TE2VTx?= MYXFR|UxRTVwNDDuUS=> NVHKXJdNOTl{MkO1OVM>
SW1736 NHqwTm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTtNE4yNTFyMDDuUS=> MmjiO|IhcA>? NVP3fohkTE2VTx?= MYTFR|UxRTVwNjDuUS=> MXSxPVIzOzV3Mx?=

... Click to View More Cell Line Experimental Data
体内研究 BI 2536静脉注射给药多种移植瘤模型，每周一次或两次，效果都很好，通过使细胞周期停滞而抑制细胞增殖，随后诱导肿瘤细胞死亡。BI 2536按 50 mg/kg剂量处理HCT 116移植瘤，每周一次或两次，显著抑制肿瘤生长，T/C 分别为15%和0.3%。BI 2536每周处理两次BxPC-3和A549模型，也显著抑制肿瘤生长，T/C分别为5% 和14%。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验： [1]
+ 展开

体外Plk1激酶实验:

重组人Plk1 (1-603残基) 作为氮端，携带杆状病毒表达系统的GST-标记的融合蛋白通过亲和层析，使用谷胱甘肽-琼脂糖而纯化。在梯度稀释的BI 2536存在时，使用 20 ng 重组激酶，及10 μg牛奶中的酪蛋白作为底物进行Plk1 酶活性实验。在终体积为60 μL 的混合物(15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP)中30oC下进行激酶反应45分钟。加入 125 μL 冰冻的5% TCA终止反应。沉淀物转移到混合酯纤维素的多屏过滤板上，使用1% TCA冲洗实验板，然后利用放射性进行测量。绘制剂量反应曲线，而计算IC50值。
细胞实验：[1]
+ 展开
  • Cell lines: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji, PC-3,等等
  • Concentrations: 溶于DMSO, 终浓度为~1 μM
  • Incubation Time: 24,和72小时
  • Method: 使用不同浓度BI 2536处理细胞24和72小时。 在荧光分光光度计中测量Alamar Blue染料转换而测定细胞生长。为了测定培养基中DNA含量，细胞悬液在80%乙醇中混合, 使用溶于PBS的0.25% Triton X-100处理5分钟，然后与0.1% RNase 和溶于PBS的 10 μg/mL碘化丙啶在室温下温育20分钟。通过流式细胞仪分析而测定细胞周期谱。
    (Only for Reference)
动物实验：[1]
+ 展开
  • Animal Models: 皮下注射HCT 116, NCI-H460, 或A549 细胞的雌性BomTac:NMRI-Foxn1nu 小鼠
  • Formulation: 在盐酸(0.1 N)中配制，然后在0.9% NaCl中稀释。
  • Dosages: ~50 mg/kg
  • Administration: 静脉注射，每周一到两次
    (Only for Reference)

溶解度 (25°C)

体外 Ethanol 100 mg/mL (191.69 mM)
DMSO 21 mg/mL (40.25 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)：
30% PEG 400+0.5% Tween 80+5% Propylene glycol 		15mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 521.66
化学式

C28H39N7O3
CAS号 755038-02-9
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量：

总分子量：g/mol

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00526149 Completed Breast Cancer|Endometrial Cancer|Head and Neck Cancer|Melanoma (Skin)|Ovarian Cancer|Sarcoma European Organisation for Research and Treatment of Cancer - EORTC July 2007 Phase 2
NCT00526149 Completed Breast Cancer|Endometrial Cancer|Head and Neck Cancer|Melanoma (Skin)|Ovarian Cancer|Sarcoma European Organisation for Research and Treatment of Cancer - EORTC July 2007 Phase 2
NCT02215044 Terminated Pancreatic Neoplasms Boehringer Ingelheim June 2007 Phase 1
NCT02215044 Terminated Pancreatic Neoplasms Boehringer Ingelheim June 2007 Phase 1
NCT00412880 Completed Carcinoma Small Cell Boehringer Ingelheim January 2007 Phase 2
NCT00412880 Completed Carcinoma Small Cell Boehringer Ingelheim January 2007 Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1：

    We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?

  • 回答：

    For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

Selleck产品目录册

PLK Signaling Pathway Map

PLK Inhibitors with Unique Features

  • 选择性强的Plk抑制剂

    GSK461364 : Plk1-selective, Ki=2.2 nM.

  • 用于临床的Plk抑制剂

    Rigosertib (ON-01910) : Phase III for Myelo Dysplastic Syndrome (MDS).

  • 最新的Plk抑制剂

    Ro3280 New : Potent, highly selective inhibitor of Polo-like kinase 1 (PLK1) with IC50 of 3 nM.

  • 经典的Plk抑制剂

    Volasertib (BI 6727) : Highly potent Plk1 inhibitor with IC50 of 0.87 nM and in phase II trials.

相关PLK产品

  • SBE 13 HCl New

    SBE 13 HCl是一种有效的选择性PLK1抑制剂，IC50为200 pM，选择性比 Aurora A 激酶, Plk2 和 Plk3高4000多倍。

  • Ro-3306 New

    RO-3306是一种ATP竞争性的选择性 CDK1 抑制剂，Ki 为20 nM，选择性是其他各种人类激酶的15倍多。

  • CCG-1423 New

    CCG-1423是一种特定的 RhoA 通路抑制剂，能够抑制SRF介导的转录。

  • Rigosertib (ON-01910)

    Rigosertib (ON-01910)是一种非ATP竞争性PLK1抑制剂，无细胞试验中IC50为9 nM，比作用于Plk2选择性高30倍，对Plk3没有抑制活性。Phase 3。

    Features:Rigosertib是作用于Polo样激酶（PLK1）的非ATP竞争性抑制剂。

  • HMN-214

    HMN-214是HMN-176的前体药物，改变了Plk1的细胞空间定位。

    Features:HMN-214 是HMN-176的口服药物前体， 是口服有效的Polo样激酶(Plk)1 抑制剂。

  • GSK461364

    GSK461364抑制纯化的Plk1，无细胞试验中Ki为2 nM。比作用于Plk2/3选择性高1000倍。Phase 1。

    Features:GSK461364是有效的，可逆的ATP竞争性的Plk1选择性抑制剂，作用于Plk1比作用于Plk2和Plk3选择性至少高390倍，而比作用于一组48种其他激酶选择性高1×103倍。

  • Volasertib (BI 6727)

    Volasertib (BI 6727)是一种高度有效的Plk1抑制剂，无细胞试验中IC50为0.87 nM，比作用于Plk2和Plk3选择性高6和65倍。Phase 3。

    Features:BI6727具有高的体积分布，良好的组织穿透力和长的半衰期。

  • MLN0905

    MLN0905是一种有效的PLK1抑制剂，IC50为2 nM。

  • Ro3280

    Ro3280是一种有效的，高选择性Polo-like kinase 1(PLK1)抑制剂，IC50为3 nM。

  • NMS-P937 (NMS1286937)

    NMS-P937（NMS1286937）是一种口服有效的，选择性Polo-like Kinase 1 (PLK1)抑制剂有,其IC50为2 nM，比PLK2/PLK3高出5000倍的选择性。第1阶段。

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID