BI 2536

For research use only. Not for use in humans.

目录号：S1109

CAS No. 755038-02-9

BI-2536是一种有效的Plk1抑制剂，无细胞试验中IC50为0.83 nM。BI-2536可抑制 Bromodomain 4 (BRD4) ，其Kd值为37 nM，并有效地抑制 c-Myc 的表达。BI-2536可诱导凋亡而减弱自噬。Phase 2。

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10mM (1mL in DMSO)	RMB 1978.87	现货
5mg	RMB 981.57	现货
50mg	RMB 5492.59	现货
100mg	RMB 8160.83	现货
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J Invest Dermatol, 2011, 131(9):1886-95

PubMed: 21654832 ( click the link to review the publication )

产品安全说明书

PLK抑制剂选择性比较

生物活性

产品描述

特性

BI 2536是第一个有效的Plk1选择性抑制剂，抑制 Plk1的标记。

靶点

c-Myc ^[3] ()	PLK1 ^[1] (Cell-free assay)	PLK2 ^[1] (Cell-free assay)	PLK3 ^[1] (Cell-free assay)	BRD4 ^[3] (Cell-free assay)
	0.83 nM	3.5 nM	9.0 nM	37 nM(Kd)

体外研究

除了Plk1, BI 2536也抑制 Plk2 和Plk3活性，只是抑制程度低点,IC50分别为3.5 nM和9.0 nM。BI 2536比一组63种其他蛋白激酶（IC50>10 μM）选择性高1000多倍。BI 2536 按10 nM 到 100 nM剂量作用于HeLa细胞，抑制有丝分裂中心体中γ-微管蛋白招募和Apc6 磷酸化，抑制染色体臂中释放黏结蛋白, 诱导产生单极主轴，及一些依赖Plk1的其他有丝分裂过程。与作用于Plk1 RNAi效果相一致, BI 2536处理HeLa细胞，使细胞周期停在G2/M期, 随后DNA分解及凋亡，且累积断裂的PARP p85片段，这种作用存在浓度依赖性。BI 2536抑制一组32种人肿瘤细胞系生长，EC50为2-25 nM,抑制指数生长的hTERT-RPE1,人脐静脉内皮细胞 (HUVECs),和正常大鼠肾脏(NRK) 细胞的增殖，EC50为12-31 nM。^[1] BI 2536 抑制Plk1，降低甲状腺未分化癌(ATC)细胞如 CAL62, OCUT-1, SW1736, 8505C,和 ACT-1 的生长的生长和活力，EC50为1.4-5.6 nM。^[2]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
PSN1	NFLJWVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXHJR\|UxRTBwMEC3O\|Yh\|ryP	M3zBXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
ACN	NWLVZpdzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M4nmd2lEPTB;MD6wNFg1OyEQvF2=	M{X2[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
TE-8	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NXP0TotZUUN3ME2wMlAxQTRzIN88US=>	NVTnXWhKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
LC-2-ad	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MluyTWM2OD1yLkCxNFk{KM7:TR?=	MkK1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
ALL-PO	M2PNSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NYfTWFJ4UUN3ME2wMlAyOyEQvF2=	NWP5WVVkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
EW-16	Mm\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NEn5O4hKSzVyPUCuNFE{OzZizszN	MmHmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
KM12	M4\UXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MkjMTWM2OD1yLkCxN\|Q5KM7:TR?=	NIjMe2I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
GI-1	M3zK[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mn[zTWM2OD1yLkCxN\|g{KM7:TR?=	M{nLRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
LS-411N	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4CzeWlEPTB;MD6wNVQxPyEQvF2=	M{X0[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
ES8	MlvFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGPBRVhKSzVyPUCuNFE1QTRizszN	NHzEbWY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
SNU-C2B	M1ixcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NXS4cpRUUUN3ME2wMlAyPTJ4IN88US=>	NI\4Z409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
CESS	M{\mVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mm\UTWM2OD1yLkCxOlAzKM7:TR?=	M3G5RVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
697	M17jZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVHJR\|UxRTBwMEG2Olgh\|ryP	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
NCI-H1963	NXPyXIJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MV7JR\|UxRTBwMEG2O\|Mh\|ryP	NXH5OVhRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
IA-LM	NEPXSmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MkjQTWM2OD1yLkCxOlg5KM7:TR?=	NG\rU\|g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
SW954	NVvLZnBOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MlfFTWM2OD1yLkCxO\|A2KM7:TR?=	NHPjT409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
RL95-2	M2HIWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MoDITWM2OD1yLkCxO\|M5KM7:TR?=	M1TI[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
LXF-289	M3fV[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M3vnPGlEPTB;MD6wNVc4KM7:TR?=	M3LkTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
OCUB-M	M1nSe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFXxcWdKSzVyPUCuNFE5OjZizszN	MlzaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
RKO	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MV7JR\|UxRTBwMEG5PFch\|ryP	M3HqPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
LOUCY	NXqwSFl1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MVzJR\|UxRTBwMEKwOUDPxE1?	M2fwb\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
NOS-1	NXzCXWFuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnK1TWM2OD1yLkCyNFk{KM7:TR?=	M4fU[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
A4-Fuk	MlXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MV;JR\|UxRTBwMEKyNVgh\|ryP	NVy5bGJWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
A388	Ml\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NX24R2l3UUN3ME2wMlAzOjJ5IN88US=>	NI[5V5o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
TE-9	NHvCeI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NEjT[49KSzVyPUCuNFIzPjFizszN	M2D4[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
KURAMOCHI	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NVXPT\|ZCUUN3ME2wMlAzOjh3IN88US=>	NUPzWZNmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
KALS-1	NIHkVpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NEnsPYlKSzVyPUCuNFI{OzhizszN	NFvnSWY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
HOP-62	M3XQV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MnLNTWM2OD1yLkCyOFIh\|ryP	MmDEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
RPMI-8402	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MWPJR\|UxRTBwMEK1NFgh\|ryP	NIfBbJk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
TE-1	NIrLTGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NYrDWZB7UUN3ME2wMlAzPTF{IN88US=>	M4XBNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
CCRF-CEM	NGjne2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NX\tWmpTUUN3ME2wMlAzPTR\|IN88US=>	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
HUTU-80	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWHPN\|VWUUN3ME2wMlAzPjJ2IN88US=>	MnTLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NCI-H1648	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MULJR\|UxRTBwMEK2OFch\|ryP	NUjyb5pMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
HCE-4	MkjkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYC2PYxyUUN3ME2wMlAzPjh{IN88US=>	M1v1dlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
ETK-1	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmOwTWM2OD1yLkCyO\|M3KM7:TR?=	NFP3WXA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
TE-15	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnfjTWM2OD1yLkCyO\|M5KM7:TR?=	M{OwRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
BE-13	NYH2OFdST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mn;vTWM2OD1yLkCyO\|Qh\|ryP	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
KE-37	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2TSXGlEPTB;MD6wNlc1OSEQvF2=	NEPPeWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NCI-H1355	NHXEbmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVzJR\|UxRTBwMEK3PFMh\|ryP	M4PTUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
TE-11	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWjNOINSUUN3ME2wMlAzQDB7IN88US=>	M3fZd\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
BL-70	MlnMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MmDXTWM2OD1yLkCyPFU4KM7:TR?=	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
ES6	M3H5WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1jsZWlEPTB;MD6wNlg5OSEQvF2=	M2rNc\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
GT3TKB	NGOwTJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2PrV2lEPTB;MD6wNlk2OyEQvF2=	NVzzemMxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
LB647-SCLC	MoPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NH7BcW5KSzVyPUCuNFMyQTVizszN	NUCydZdxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
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Daudi	NUjqU4duT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHzlUlRKSzVyPUCuNFgzPTZizszN	MmnHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
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BB65-RCC	NV:zNm9ZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NULLdVl3UUN3ME2wMlExOjl2IN88US=>	NH\jdIo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
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NOMO-1	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnHuTWM2OD1yLkSzPFYh\|ryP	NU\TTnF7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
J-RT3-T3-5	Ml;tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MoDZTWM2OD1yLkS0PFc5KM7:TR?=	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
COLO-668	MmDpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MkXPTWM2OD1yLkS1OlY5KM7:TR?=	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
SF539	NYLVTGNbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NWS5bZlYUUN3ME2wMlQ5Pjh2IN88US=>	NWLxenR2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
LB2518-MEL	MmXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2\vbmlEPTB;MD60PVcxOyEQvF2=	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
TE-441-T	M3jCdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MoHGTWM2OD1yLkWwNVIh\|ryP	NGDLO5I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
MDA-MB-134-VI	NGnPc2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NGPZRnFKSzVyPUCuOVA6OjFizszN	Mlv2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
SCC-3	MnrNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NXPkSIpkUUN3ME2wMlUyQDd\|IN88US=>	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
KLE	NEPLUZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NIrVc\|BKSzVyPUCuOVIyPzFizszN	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
LB2241-RCC	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4nIfWlEPTB;MD61NlUzPSEQvF2=	MkXaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NCI-H1417	NHLrZmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MlLQTWM2OD1yLkWzOFM2KM7:TR?=	MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
NCI-H2081	NWDiZ2l5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NH3IcWNKSzVyPUCuOVg3OTFizszN	MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
NCI-H1522	M3PY[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MWHJR\|UxRTBwNUmzPFMh\|ryP	NV\mdpdNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NCI-H889	MmLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Ml34TWM2OD1yLkW5PFQ1KM7:TR?=	NHLXXJM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
CGTH-W-1	Mn\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NIXSR5RKSzVyPUCuOlA4PTVizszN	NX;ySVEyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
EB-3	Mo\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MV;JR\|UxRTBwNkGxOVMh\|ryP	M4XKbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
D-336MG	M1HIRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NGntdGRKSzVyPUCuOlE4QTFizszN	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
LC-1F	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmjMTWM2OD1yLk[yOVkzKM7:TR?=	MkLLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
MHH-NB-11	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M37Lc2lEPTB;MD62N\|gxOSEQvF2=	M2LUd\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
SK-N-FI	NVXucnB[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnflTWM2OD1yLk[zPVEh\|ryP	NHHtO3g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NCI-H69	NYWwTmk1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MkXmTWM2OD1yLk[0PFc6KM7:TR?=	NU[wNoM3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
SCH	M{jtPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFLVTXZKSzVyPUCuOlYxOjNizszN	NEnEVlE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
LS-513	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnzUTWM2OD1yLk[3NlU6KM7:TR?=	M2KzTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
CP67-MEL	NEfVRnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MW\JR\|UxRTBwNke1PVYh\|ryP	NHnUVIU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
GCIY	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MkXOTWM2OD1yLkewN\|Y{KM7:TR?=	NW\t[I84RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
SHP-77	Mlu5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYPJR\|UxRTBwN{C3N\|Qh\|ryP	MkPXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
EHEB	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NIXXVWVKSzVyPUCuO\|E5PTRizszN	MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
D-247MG	M2DhZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NGW1VmNKSzVyPUCuO\|MzOzJizszN	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
Raji	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MWjJR\|UxRTBwN{S5PFkh\|ryP	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
MPP-89	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{fqNmlEPTB;MD63OVk4QCEQvF2=	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
EKVX	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUDJR\|UxRTBwN{mwO\|Mh\|ryP	M4TYS\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
HCC2218	NGPNfYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1TBRmlEPTB;MD63PVE{OSEQvF2=	M2LXWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
KNS-81-FD	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MWfJR\|UxRTBwOEGwNVEh\|ryP	MmO5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
HCC2157	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUDJR\|UxRTBwOES5OVEh\|ryP	NHXLSo89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
BT-474	M1zQb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVjJR\|UxRTBwOEi4OVQh\|ryP	M2HKZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
NCI-H748	NW\l[\|VTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NE\xUopKSzVyPUCuPVEzKM7:TR?=	NHzFc4M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
EW-24	MoOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NH[wTopKSzVyPUCuPVIxODJizszN	MlHpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
D-263MG	NGHsPVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NGDYW2JKSzVyPUCuPVQ2OTJizszN	MoH5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
OMC-1	NVHmcGxUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NVjVbpJ3UUN3ME2wMlk3Ozd\|IN88US=>	NGnXS4U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NCI-H2196	M1Tncmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NF7INVJKSzVyPUCuPVc4PzdizszN	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
HAL-01	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2\ieGlEPTB;MD65PVg4OiEQvF2=	NGT2NGU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NCI-H2107	NVLKOYJUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUD4V3NRUUN3ME2xMlAyQDV2IN88US=>	NELhSZU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
LB996-RCC	NF2wSJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXmyb4NXUUN3ME2xMlA5ODVzIN88US=>	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
NCI-H1395	NHHPd2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2\XVmlEPTB;MT6xNFY4KM7:TR?=	NIHuV2M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
CHP-126	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NGK5O5dKSzVyPUGuNVYyQTlizszN	NIXkRmQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NB69	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUfJR\|UxRTFwMk[xOFgh\|ryP	MoHwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
CAS-1	NVrMOVVGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXvJR\|UxRTFwM{SyN\|Eh\|ryP	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
JVM-3	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NVrHSGpEUUN3ME2xMlQ4QDV3IN88US=>	NEmxOZU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
DMS-153	M1LXOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MUHJR\|UxRTFwNUe2O\|Qh\|ryP	NGXhSXk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
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C8166	NFXPemNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MnW0TWM2OD1zMz64N\|A{KM7:TR?=	M4f3R\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
ES3	M4\jXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2HmW2lEPTB;MUOuPVk4PyEQvF2=	MlTaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NCI-H1650	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MWrJR\|UxRTF4LkO3OlUh\|ryP	M3X6SlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
Mo-T	NW\0TY9CT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M4LzUGlEPTB;MUeuOFAzQSEQvF2=	NULFNXQ1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NB7	MnzjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MX\JR\|UxRTF5Lke0Olch\|ryP	MmP2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
ES7	MlT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MmnvTWM2OD1zOT61OVA4KM7:TR?=	MlK1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
ES5	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFHkNYZKSzVyPUKxMlc3PzFizszN	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
MSTO-211H	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{i1RmlEPTB;MkGuPFg2QCEQvF2=	M2e3b\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
U-87-MG	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{ezV2lEPTB;MkWuNVk3PiEQvF2=	MnnaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
THP-1	M1WwRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NUTtbYcyUUN3ME2yPU44OjBzIN88US=>	Mk[yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NB10	NGPM[I1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MmrjTWM2OD1\|MD6yOlk1KM7:TR?=	MoS0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NH-12	NFrvOXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NYfDZmxKUUN3ME2zN{4zODF5IN88US=>	NIfsfpg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
COLO-824	MnjWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NETSOG1KSzVyPUO0MlExODZizszN	Ml7OQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
SKM-1	NGj2NW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWjqVZdUUUN3ME2zO{45PDJ{IN88US=>	NHr1PYM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NCI-H1838	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NH;OfmJKSzVyPUO4MlM4QTdizszN	M1TWOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
RL	NE\UOGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUO4eWhEUUN3ME2zPU4zPDd5IN88US=>	NHP5RnA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
COLO-800	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NGfqfXNKSzVyPUSwMlA4PzNizszN	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
KG-1	NWrhcJlDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MYjJR\|UxRTRyLki5OVUh\|ryP	NG\he4w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
TUR	NG\t[ItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mo\0TWM2OD12MT62N\|k6KM7:TR?=	NWS2TGFJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
LNCaP-Clone-FGC	MmnZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MW\JR\|UxRTRzLkmwNVch\|ryP	MkK1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NCI-H322M	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MXrJR\|UxRTR{LkW5PFQh\|ryP	MknNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
LNCaP	NXPhV\|g1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1PDOGlEPTB;OUGuN{BvVQ>?	NIPnV\|k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUWwOVE4PCd-MkW1NFUyPzR:L3G+
C4-2	Mli4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MWHJR\|UxRThibl2=	M{HwbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NUC1NVc1Lz5{NUWwOVE4PDxxYU6=
JURKAT	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MkD2NlQhcA>?		NGLqNI5KSzVyPUSxOk43PiCwTR?=	NHz6N4o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
MOLT-4	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MVOyOEBp		MofxTWM2OD1{OEWzMlUhdk1?	NYjhVFRkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NVk6QTVpPkK0OVE6QTl3PD;hQi=>
REH	NYnjToFqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		M1jIUlI1KGh?		MWrJR\|UxRTJ6Nz62PEBvVQ>?	M3SxTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
NALM-6	Mk\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NVPiOnRKOjRiaB?=		NGHsOZFKSzVyPUO0N\|MxKG6P	M3fpNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
RS 4;11	M4HWcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NX;mW4pKOjRiaB?=		NXXlXWRuUUN3ME21NVkvODVibl2=	NH\ZZ\|k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
697	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MYKyOEBp		NEjCU3pKSzVyPUKxNFcvOSCwTR?=	NHTiSZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
SIL-ALL	NHnLN2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		M4D4clI1KGh?		MXvJR\|UxRTF7OT63O{BvVQ>?	M3jTXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
CEM	NIG3SJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NGfXV44zPCCq		MW\JR\|UxRTV{LkG4JI5O	NUnrTlhQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NVk6QTVpPkK0OVE6QTl3PD;hQi=>
P12	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NE\DbpUzPCCq		M3fQbmlEPTB;M{muNlchdk1?	M3[5UVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
NALM-16	Moe4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MlewNlQhcA>?		NFmwSY9KSzVyPUm2MlI5KG6P	NYjie4Z3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NVk6QTVpPkK0OVE6QTl3PD;hQi=>
JURKAT	M3i3OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NGLrVYY1QCCq		MUnJR\|UxRTF2Lki0JI5O	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
MOLT-4	NF7Wc\|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NHj3Xo01QCCq		MmTmTWM2OD1{Nj62JI5O	M4qySFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
REH	NYnnWpc1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NYqxXHJtPDhiaB?=		M1KzPGlEPTB;NESuO\|Ehdk1?	MkfmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
NALM-6	M1j4SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		M2T2blQ5KGh?		NILh[FZKSzVyPUKzMlI3KG6P	M2\6UFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
RS 4;11	NHnZSVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MlPLOFghcA>?		MULJR\|UxRTF4ND6yPEBvVQ>?	MkXHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
697	NVzvd4ZOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NHXDbWg1QCCq		M3PtcGlEPTB;M{C1MlMhdk1?	M33KWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
SIL-ALL	NUH6NGt5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NF7vdXE1QCCq		Mn\NTWM2OD15ND62NkBvVQ>?	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
CEM	M{LjfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NVjDWJZ6PDhiaB?=		NHX6WHVKSzVyPUK0MlU2KG6P	NWjPRXhWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NVk6QTVpPkK0OVE6QTl3PD;hQi=>
P12	M1L6c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MlXQOFghcA>?		MnLBTWM2OD1zOD60OkBvVQ>?	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
NALM-16	NH3ISWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NHvhfWk1QCCq		MlzCTWM2OD14Mz6yOEBvVQ>?	NIHoSFM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
JURKAT	NIXxfGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NXjVU20zPzJiaB?=		NFvoRWdKSzVyPUOuOlUhdk1?	MmqwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
MOLT-4	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NWnvR2hyPzJiaB?=		NXGyNGtIUUN3ME23MlM6KG6P	MkfvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
REH	NHjhS2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		M175dlczKGh?		MojmTWM2OD1zNj6wNUBvVQ>?	MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
NALM-6	MnK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NHfoU4s4OiCq		NHXjVmhKSzVyPUGuO\|ghdk1?	NETkU2M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
RS 4;11	NGXsSIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		M37pV\|czKGh?		NWfSe5dKUUN3ME20MlM5KG6P	M1;MdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
697	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NGfxVWQ4OiCq		NYPzbpFHUUN3ME23OE4zQCCwTR?=	MnnWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
SIL-ALL	M2fjT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NGLYdFU4OiCq		M{HUSGlEPTB;Nz6yJI5O	NVvhR\|FMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NVk6QTVpPkK0OVE6QTl3PD;hQi=>
CEM	NUC5UlNHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MoXzO\|IhcA>?		MnXTTWM2OD13LkSyJI5O	M4HUTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
P12	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MV23NkBp		MkjjTWM2OD14LkO3JI5O	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
NALM-16	NUD3RlVYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NIj3VXQ4OiCq		MoDJTWM2OD15Nz63N{BvVQ>?	M3n2blxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
Y79	Ml;1RZBweHSxc3nzJGF{e2G7	M4Pnb\|EuPTBibl2=	MoTaNVIwOjRiaB?=	MoLQSG1UVw>?	Mme0bY5lfWOnZDDhdI9xfG:\|aYOge4hq[2hiY3HuJIJmKGWwaHHuZ4VlKGK7IFjU	NX:1U5JNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzOlY3PjVpPkK0N\|Y3PjZ3PD;hQi=>
WER-Rb-1	NVPOb5c5SXCxcITvd4l{KEG\|c3H5	MkfENU02OCCwTR?=	NVj2RZJ7OTJxMkSgbC=>	M1XyVmROW09?	MoT2bY5lfWOnZDDhdI9xfG:\|aYOge4hq[2hiY3HuJIJmKGWwaHHuZ4VlKGK7IFjU	MlvvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR\|Nk[2OlUoRjJ2M{[2OlY2RC:jPh?=
G7	NYL2SnNxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnTCTWM2OD1\|LkOgcm0>	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDJyNEezN{c,OjR{MES3N\|M9N2F-
G166	M2jVO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2jldWlEPTB;Nz6wJI5O	NGHmWm09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEKwOFc{Oyd-MkSyNFQ4OzN:L3G+
CB660	NUX4dIpuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MoXLTWM2OD14LkSgcm0>	NF7t[m09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEKwOFc{Oyd-MkSyNFQ4OzN:L3G+
CB1117	NIS0VFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M33YXGlEPTB;MUWuOkBvVQ>?	MlqyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{MES3N\|MoRjJ2MkC0O\|M{RC:jPh?=
KB-3-1	NH;HXoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MYDJR\|UxRTFwNEigxtEhOC53MzDuUS=>	Mn20QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkK0OFUoRjJ\|OU[yOFQ2RC:jPh?=
KB-8-5-11	NXrzZnB7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2H1bGlEPTB;NT6wNUDDuSB{LkCxJI5O	MkXGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkK0OFUoRjJ\|OU[yOFQ2RC:jPh?=
KB-C-1	NHLEc4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFPtbmZKSzVyPUG2Mlc3KMLzIESuOVEhdk1?	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4MkS0OUc,OjN7NkK0OFU9N2F-
KB-V-1	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MkTXTWM2OD1{OEGuNlQhyrFiM{GuOVchdk1?	NX\rXVM4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5OlI1PDVpPkKzPVYzPDR3PD;hQi=>
OVCAR-8	NFz6R3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVTJR\|UxRTdwMUmgxtEhOy54MDDuUS=>	MlnSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkK0OFUoRjJ\|OU[yOFQ2RC:jPh?=
NCI-ADR-RES	NFfzVYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFG2bmRKSzVyPUGyO\|MvOzBiwsGgNVkyNjJyIH7N	MoK5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkK0OFUoRjJ\|OU[yOFQ2RC:jPh?=
MCF7	NVS2fnJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHXRZ3FKSzVyPUWuNVEhyrFiMT60O{BvVQ>?	NYjDRYNxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5OlI1PDVpPkKzPVYzPDR3PD;hQi=>
MCF7-FLV1000	NEPTeGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NGjWToJKSzVyPUO5N{4yQCEEsTC3OE45OyCwTR?=	NUXPfo9sRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5OlI1PDVpPkKzPVYzPDR3PD;hQi=>
S1	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlixTWM2OD1{ND6zNEDDuSB2Lke1JI5O	Mk\zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkK0OFUoRjJ\|OU[yOFQ2RC:jPh?=
S1-M1-80	MofhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGrnfllKSzVyPUK2NU4xPiEEsTC0PE4zPSCwTR?=	M13qV\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OU[yOFQ2Lz5{M{m2NlQ1PTxxYU6=
CORL-23/P	NIPadIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MkjiTWM2OD12LkO4JOKyKDFwMkWgcm0>	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4MkS0OUc,OjN7NkK0OFU9N2F-
CORL-23/R	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{PwbmlEPTB;NT6xOkDDuSBzLkizJI5O	MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4MkS0OUc,OjN7NkK0OFU9N2F-
NIH3T3	MlrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHX3RZlKSzVyPUSwMlYxKMLzIESuPVchdk1?	NHLYV2Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2NlQ1PSd-MkO5OlI1PDV:L3G+
NIH3T3-G185	Moe4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1G2fWlEPTB;MkSxN{41OCEEsTC0NlMvPjZibl2=	MmLJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkK0OFUoRjJ\|OU[yOFQ2RC:jPh?=
pcDNA-HEK293	NELafmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXf3fVVYUUN3ME2yMlc2KMLzIECuOlchdk1?	NHztem49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2NlQ1PSd-MkO5OlI1PDV:L3G+
MDR19-HEK293	NHfxT4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2PXU2lEPTB;OEWuOVAhyrFiMUOuOlchdk1?	MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4MkS0OUc,OjN7NkK0OFU9N2F-
R482-HEK293	NXu3WmhlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MmLRTWM2OD1{NT65O{DDuSB2Lkm1JI5O	NH7z[pk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2NlQ1PSd-MkO5OlI1PDV:L3G+
MRP1-HEK293	M1flXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mn3TTWM2OD1{Lkm5JOKyKDFwNEmgcm0>	MnH2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkK0OFUoRjJ\|OU[yOFQ2RC:jPh?=
SF188	NULxOXVMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NX;DSJBpOTBvMUCwJI5O	MlfxNlQuQTZiaB?=	NXn3NGxUTE2VTx?=	M2nQeolvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHLveIghfGmvZT2gZY5lKGOxbnPlcpRz[XSrb36tJIRmeGWmZX70JI1idm6nch?=	NUe1N4NbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4PFc3PDVpPkKzPFg4PjR3PD;hQi=>
T98G	M4PjUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWTUeJZlOTBvMUCwJI5O	NVnXdXpqOjRvOU[gbC=>	MVTEUXNQ	MkHobY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iY3;uZ4VvfHKjdHnvck0h\GWyZXTlcpQhdWGwbnXy	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzh6N{[0OUc,OjN6OEe2OFU9N2F-
DU145	NEPDSIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NEP6W4pFVVOR	MoHVTWM2OOLKvE[wJI5O	MnPuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6OES0NlgoRjJ\|OEi0OFI5RC:jPh?=
LNCaP	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NHznZ4JFVVOR	MX3JR\|Ux6oj:N{Wgcm0>	NWC2d\|BtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4PFQ1OjhpPkKzPFg1PDJ6PD;hQi=>
PC3	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NWDjd25STE2VTx?=	NVPzPIJ{UUN3MPMIwFE4PSCwTR?=	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzh6NESyPEc,OjN6OES0Nlg9N2F-
RT4	NFXsdo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVzzc\|lFUUN3ME2yO{4zOSCwTR?=	MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd7Mk[zPUc,OjN5OUK2N\|k9N2F-
5637	NYj4T3drT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MVXJR\|UxRTR3LkS3JI5O	M3rmWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|N{myOlM6Lz5{M{e5NlY{QTxxYU6=
T24	NF70NXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUTZTIdOUUN3ME23PU4yOiCwTR?=	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd7Mk[zPUc,OjN5OUK2N\|k9N2F-
MCF7	MnHZSpVv[3Srb36gRZN{[Xl?	NW\PbJJxOTByIH7N	NHfIWGQyKGh?	MXHEUXNQ	M1nIPZJm\HWlZYOgeIhmKGmwZIXjeIlwdiCxZtMgS5Jm[jFuwrDT[4syNMLiUIOyMOKhW2W{cHnuZVMtKGGwZNMgW4l{eDJ?	NUjPeJMxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO3O\|AzPDRpPkKzO\|cxOjR2PD;hQi=>
KB-V1	M{fOdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Ml;tTWM2OD1\|LkmyJO69VQ>?	MkTXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3OUOxPVYoRjJ\|NUmzNVk3RC:jPh?=
Hec50co	M1ruTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NWHsdXBpUUN3ME21JI5O	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzF2Nk[4O{c,OjNzNE[2PFc9N2F-
MDA-MB-468	NV7xWI4ySXCxcITvd4l{KEG\|c3H5	NFryeXkyNzVxMUCgcm0>	Mkj2NlQwPDhxN{KgbC=>	MXXEUXNQ	Ml:0bY5lfWOnczDhdI9xfG:\|aYOgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK=	MofDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNzNESyPVQoRjJ\|MUS0Nlk1RC:jPh?=
MCF10A	MUHBdI9xfG:\|aYOgRZN{[Xl?	NFrKeFEyNzVxMUCgcm0>	MlfqNlQwPDhxN{KgbC=>	MoK1SG1UVw>?	M1fTcolv\HWlZYOgZZBweHSxc3nzJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy	NHPLdok9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{G0OFI6PCd-MkOxOFQzQTR:L3G+
Huh-7	Mk\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4PqbVEwOTBxMUCwM\|ExODBibl2=	NWq3TGEyPDhiaB?=		NGDXRoRl\WO{ZXHz[ZMhfGinIHPlcIwhfmmjYnnsbZR6KGSxc3Wt[IVx\W6mZX70cJk>	NEi3SXA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mke0OVU5Pyd-MkK3OFU2QDd:L3G+
Daoy	Ml22S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{HxVlEvQDd3LUK0NEBvVQ>?	MlP5O\|IhcA>?	NXvkWVRNTE2VTx?=	NFHvPVJKSzVyPUWgcm0>	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN7MEK3PUc,OjJ\|OUCyO\|k9N2F-
ONS-76	NYj2WXl{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYfkSlB6OS56N{WtNlQxKG6P	NVizSVc4PzJiaB?=	NHXCN5FFVVOR	MX;JR\|UxRTdwNTDuUS=>	MmPKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ\|OUCyO\|koRjJ{M{mwNlc6RC:jPh?=
SUM 149	M17Iemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkL4NE0yODBibl2=	NYjINo5[PzJiaB?=		NYHHOINwcW6qaXLpeJMhfGinIHPlcIwhfmmjYnnsbZR6KGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoFz	M33yT\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{C5PVM6Lz5{MkOwPVk{QTxxYU6=
MDA-MB-231	M1O4VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmrjNE0yODBibl2=	M1uxdlczKGh?		NVX5dJJOcW6qaXLpeJMhfGinIHPlcIwhfmmjYnnsbZR6KGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoFz	M1yweFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{C5PVM6Lz5{MkOwPVk{QTxxYU6=
HR5	NWmxTpk3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MoDlNE0yODBibl2=	MlnWO\|IhcA>?		NUHvTlZQcW6qaXLpeJMhfGinIHPlcIwhfmmjYnnsbZR6KGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoFz	M1LSTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{C5PVM6Lz5{MkOwPVk{QTxxYU6=
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BT-12	M17OfZFJXFNiYYPzZZk>				MofYdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgRnQuOTJiY3XscJM>	MmfhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
LAN-5	MofldWhVWyCjc4PhfS=>				MUjxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDMRW4uPSClZXzsdy=>	NWHXPWxQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
Fibroblast cells	M{TZXZFJXFNiYYPzZZk>				M1S4PJFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiClb370do9tKEiqIIfpcIQhfHmyZTDmbYJzd2KuYYP0JINmdGy\|	Mo\hQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
NB-EBc1	M{faU5FJXFNiYYPzZZk>				NX3xSJByeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhVkJvRVLjNUBk\Wyucx?=	MlzwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
SK-N-SH	M1\PU5FJXFNiYYPzZZk>				M2fUV5FJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJHNMNU5vU1igZ4VtdHN?	M3u4PFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
A673	MYjxTHRUKGG\|c3H5				MYTxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDBOlc{KGOnbHzzLS=>	NIX5Oog9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
BT-37	NIrGVZVyUFSVIHHzd4F6				M{fWNpFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJGJVNTN5IHPlcIx{	NXyyU3pFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
MG 63(6-TG R)	NHX2bWNyUFSVIHHzd4F6				MUfxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDNS{A3OyBqNj3US{BTMSClZXzsdy=>	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
Fibroblast cells	MkOzdWhVWyCjc4PhfS=>				MXnxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDjc451em:uIFjoJJdqdGRidInw[UBncWK{b3LsZZN1KGOnbHzz	M4jSdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
OHS-50	NWCxWJQ2eUiWUzDhd5NigQ>?				NF20XFhyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBQUFNvNUCgZ4VtdHN?	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
RD	NHfZdGhyUFSVIHHzd4F6				MYjxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDSSEBk\Wyucx?=	M1THeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SJ-GBM2	MlLWdWhVWyCjc4PhfS=>				NUi1Vpg{eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IGPKMWdDVTJiY3XscJM>	NHixOWg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
SK-N-MC	NXnBXmZ6eUiWUzDhd5NigQ>?				M2[0WZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCVSz3OMW1EKGOnbHzz	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
NB-EBc1	MlzZdWhVWyCjc4PhfS=>				M{TnbpFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCQQj3FRoMyKGOnbHzz	NXnIOJZ5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
LAN-5	M3z5S5FJXFNiYYPzZZk>				M1PYd5FJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCOQV6tOUBk\Wyucx?=	MmT6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
Rh18	MnWxdWhVWyCjc4PhfS=>				NF\MOlRyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiUnixPEBk\Wyucx?=	MkH2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
NB1643	MVXxTHRUKGG\|c3H5				MlrqdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgUmIyPjR\|IHPlcIx{	MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
SK-N-MC	NF6yXlZyUFSVIHHzd4F6				MofWdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgV2suVi2PQzDj[Yxtew>?	M2PGSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SJ-GBM2	MVrxTHRUKGG\|c3H5				MWrxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDTTk1ISk1{IHPlcIx{	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
TC32	NIrrbVVyUFSVIHHzd4F6				NVy4UoM6eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhXEN\|MjDj[Yxtew>?	NVuzW\|hSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
Rh18	NWjPZ2xWeUiWUzDhd5NigQ>?				NYTTTZE6eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhWmhzODDj[Yxtew>?	M3;XdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
Saos-2	NXnqeHQ3eUiWUzDhd5NigQ>?				MVPxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDTZY9{NTJiY3XscJM>	NEXQZok9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
DU145	MoroRZBweHSxc3nzJIF{e2G7	MVexNFAhdk1?	M4PlV\|I1KGi{cx?=		NFrWSINKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m\|IHnuJIh2dWGwIFTVNVQ2KGOnbHzzJIF{e2W\|c3XkJIF{KGmwY4LlZZNmKGmwIGDBVnAh[2ynYY\h[4Uh[XRiMUCwJI5OKGGodHXyJFI1KGi{czDifUBqdW23bn;icI91fGmwZzDt[ZRpd2R?	MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ6NUm0NUc,OjV4OEW5OFE9N2F-
HeLa	NGTGR\|lHfW6ldHnvckBie3OjeR?=	Ml7CNVAxKG6P			NUfPUVJ3UW6qaXLpeIlwdiCxZjDQUGsyKFSqckKxNEBxcG:\|cHjvdplt[XSrb36gbY4hcHWvYX6gTIVN[SClZXzsd{BifCBzMECgcm0h[nliaX3teY5w[myxdITpcochdWW2aH;k	MlnRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4OEW5OFEoRjJ3Nki1PVQyRC:jPh?=
DU145	MlzpSpVv[3Srb36gZZN{[Xl?	NH;zOGkyODBibl2=			MmG1TY5pcWKrdHnvckBw\iCSTFuxJJBzd3SnaX6gZYNkfW23bHH0bY9vKGmwIHj1cYFvKESXMUS1JINmdGy\|IHH0JFExOCCwTTDifUBqdW23bn;icI91fGmwZzDt[ZRpd2R?	NX73dXhLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2PFU6PDFpPkK1Olg2QTRzPD;hQi=>
HeLa	M4DQVGZ2dmO2aX;uJIF{e2G7	NX7TWXR5OTByIH7N			MkTwTY5pcWKrdHnvckBw\iCSTFuxJJBzd3SnaX6gZYNkfW23bHH0bY9vKGmwIHj1cYFvKEinTHGgZ4VtdHNiYYSgNVAxKG6PIHL5JIludXWwb3Lsc5R1cW6pIH3leIhw\A>?	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ6NUm0NUc,OjV4OEW5OFE9N2F-
HeLa	NXyyTJluTnWwY4Tpc44h[XO\|YYm=	MmDrNVAxKG6P	NIf1enIyQCCqcoO=		NFn0[GVKdmS3Y4Tpc44hd2ZibX;uc5BwdGG{IH3peI91cWNic4DpcoRt\XNiaX6gbJVu[W5iSHXMZUBk\WyuczDheEAyODBibl2gbY5kfWKjdHXkJIZweiBzODDodpMh[nliaX7kbZJm[3RiaX3teY5w\my3b4Lld4NmdmOnIH3pZ5Jwe2OxcIm=	MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ6NUm0NUc,OjV4OEW5OFE9N2F-
HeLa	MUfBdI9xfG:\|aYOgZZN{[Xl?	NVXBV\|B3OTByIH7N	MXWyOEBpenN?		MkTSTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCKZVzhJINmdGy\|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKFCDUmCgZ4xm[X[jZ3WgZZQhOTByIH7NJIFnfGW{IEK0JIhzeyCkeTDpcY12dm:kbH;0eIlv\yCvZYToc4Q>	NFXmT\|g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[4OVk1OSd-MkW2PFU6PDF:L3G+
PC3	Mo\aSpVv[3Srb36gZZN{[Xl?	NGTiTXEyODBibl2=	MUOxPEBpenN?		MnLSTY5lfWO2aX;uJI9nKG2xbn;wc4xieiCvaYTveIlkKHOyaX7kcIV{KGmwIHj1cYFvKFCFMzDj[YxteyCjdDCxNFAhdk1iaX7jeYJifGWmIH\vdkAyQCCqcoOgZpkhcW6maYLlZ5QhcW2vdX7v[ox2d3Knc3PlcoNmKG2rY4Lvd4NweHl?	NGnPS\|A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[4OVk1OSd-MkW2PFU6PDF:L3G+
DU145	NWD3S5ZYTnWwY4Tpc44h[XO\|YYm=	M3fPfFExOCCwTR?=			M33DNWlvcGmkaYTpc44hd2ZiUFzLNUBVcHJ{MUCgdIhwe3Cqb4L5cIF1cW:wIHnuJIh2dWGwIFTVNVQ2KGOnbHzzJIF1KDFyMDDuUUBjgSCrbX31co9jdG:2dHnu[{Bu\XSqb3S=	M4PFXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Nki1PVQyLz5{NU[4OVk1OTxxYU6=

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Assay

Methods	Test Index	PMID
Western blot	pro-caspase-8 / cleaved caspase-8 / cleaved caspase-3 / cleaved caspase-9; PubMed: 27699933 Cancer Sci PLKi‐induced caspase activation. HeLa cells were treated with BI 2536 (10 nmol/L), BI 6727 (68 nmol/L), or GSK461364 (11 nmol/L), and HCT 116 cells were treated with BI 2536 (20 nmol/L), BI 6727 (70 nmol/L), or GSK461364 (12 nmol/L) for 48 h. The levels of cleaved caspase (CASP)‐3, ‐8, and ‐9 were examined by Western blot analysis. p-HH3 / PARP / Myc / p-Myc; PubMed: 24771642 Clin Cancer Res Western blotting showing more mitotic arrested (shown by phospho-histone H3) and apoptotic (shown by PARP) cells as well as lower MYC levels in LNCaP-Pim1 cells after BI 2536 treatment compared with LNCaP-Neo cells. The difference is obvious at lower dose of BI 2536 (10 nM). Both total MYC expression and phosphor-MYC levels were lower in Pim1 cells than Neo cells after BI 2536 treatment. pMEK / MEK / pERK / ERK / pRSK1 / RSK1; PubMed: 28430578 Oncotarget (A) and (B) Western blot analysis of the expression and activation of components of the MEK-ERK-RSK1 pathway in MKN45 and MKN74 cancer cells treated with BI 2536 and BI 6727 for 24 and 48 hours, respectively. pPlk1 / Plk1 / pMyt1; PubMed: 28430578 Oncotarget (A) and (B) Western blot analysis of the expression and phosphorylation of Plk1, and phosphorylation of Myt1 in the CSC-like and cancer cells after treatment with BI 2536 and BI 6727 for 24 and 48 hours, respectively. Aurora B / pAurora B / pAurora C / pH3 / Cyclin B1 / Securin / pBcl-XL / MPM2; PubMed: 25169932 Mol Oncol Western blot analysis of cells treated for 24 h with the indicated inhibitor concentrations. Cell lysates were immunoblotted for Plk1, Phospho-Aurora B (T232)/Aurora C (T198), Aurora B, histone H3 phosphorylated at S10 (pH3), Cdk1, Cyclin B1, Securin, Phospho-Bcl-XL, Induced myeloid leukemia cell differentiation protein Mcl-1, MPM-2 and β-Actin. Left (Hela cells); Right (HUVEC)	27699933 24771642 28430578 25169932
Immunofluorescence	p-H2AX / propidium iodide; PubMed: 22309939 Breast Cancer Res Apoptotic images of the cells after BI 2536 treatment, as revealed by HCS (high-content screening) instrument (×10) with phospho-H2AX antibody or PI (propidium iodide) intake. Pericentrin / α-tubulin; PubMed: 21772266 Nat Commun MEFs were labelled using Plk1, pericentrin and α-tubulin antibodies and 4,6-diamidino-2-phenylindole for the analysis by immunofluorescence microscopy. Representative examples of BI 2536-treated and control MEFs are depicted. Scale bar, 5 μm.	22309939 21772266
Growth inhibition assay	Cell viability; PubMed: 21772266 Nat Commun Proliferative activity of MEFs at different BI 2536 concentrations (25–250 nM; means±s.d., n=3, for each concentration). P<0.05, P<0.01, **P<0.001, Student's t-test, unpaired and two-tailed.	21772266

体内研究

BI 2536静脉注射给药多种移植瘤模型，每周一次或两次，效果都很好，通过使细胞周期停滞而抑制细胞增殖，随后诱导肿瘤细胞死亡。BI 2536按 50 mg/kg剂量处理HCT 116移植瘤，每周一次或两次，显著抑制肿瘤生长，T/C 分别为15%和0.3%。BI 2536每周处理两次BxPC-3和A549模型，也显著抑制肿瘤生长，T/C分别为5% 和14%。^[1]

激酶实验： ^[1]	- 合并体外Plk1激酶实验: 重组人Plk1 (1-603残基) 作为氮端，携带杆状病毒表达系统的GST-标记的融合蛋白通过亲和层析，使用谷胱甘肽-琼脂糖而纯化。在梯度稀释的BI 2536存在时，使用 20 ng 重组激酶，及10 μg牛奶中的酪蛋白作为底物进行Plk1 酶活性实验。在终体积为60 μL 的混合物(15 mM MgCl₂, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-³³P-ATP)中30^oC下进行激酶反应45分钟。加入 125 μL 冰冻的5% TCA终止反应。沉淀物转移到混合酯纤维素的多屏过滤板上，使用1% TCA冲洗实验板，然后利用放射性进行测量。绘制剂量反应曲线，而计算IC50值。
细胞实验： ^[1]	- 合并 Cell lines: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji, PC-3,等等 Concentrations: 溶于DMSO, 终浓度为~1 μM Incubation Time: 24,和72小时 Method: 使用不同浓度BI 2536处理细胞24和72小时。在荧光分光光度计中测量Alamar Blue染料转换而测定细胞生长。为了测定培养基中DNA含量，细胞悬液在80%乙醇中混合, 使用溶于PBS的0.25% Triton X-100处理5分钟，然后与0.1% RNase 和溶于PBS的 10 μg/mL碘化丙啶在室温下温育20分钟。通过流式细胞仪分析而测定细胞周期谱。 (Only for Reference)
动物实验： ^[1]	- 合并 Animal Models: 皮下注射HCT 116, NCI-H460, 或A549 细胞的雌性BomTac:NMRI-Foxn1nu 小鼠 Dosages: ~50 mg/kg Administration: 静脉注射，每周一到两次 (Only for Reference)

参考文献

溶解度 (25°C)

体外	Ethanol	100 mg/mL (191.69 mM)
	DMSO	21 mg/mL (40.25 mM)
	Water	Insoluble
体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： 5%DMSO+40%PEG300+5%Tween80+50%ddH2O	12.5mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download BI 2536 SDF

分子量	521.66
化学式	C₂₈H₃₉N₇O₃
CAS号	755038-02-9
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	N/A

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

临床试验信息 (data from https://clinicaltrials.gov, updated on 2021-09-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT02215044	Terminated	Drug: BI 2536 intravenous\|Drug: Gemcitabine intravenous	Pancreatic Neoplasms	Boehringer Ingelheim	June 2007	Phase 1
NCT02211833	Completed	Drug: BI 2536\|Drug: Pemetrexed	Carcinoma Non-Small-Cell Lung	Boehringer Ingelheim	October 2006	Phase 1
NCT00701766	Completed	Drug: BI 2536	Leukemia Myeloid Acute	Boehringer Ingelheim	October 2006	Phase 2
NCT00706498	Completed	Drug: BI 2536	Prostatic Neoplasms	Boehringer Ingelheim	September 2006	Phase 2
NCT00376623	Completed	Drug: BI 2536	Carcinoma Non-Small-Cell Lung	Boehringer Ingelheim	July 2006	Phase 2
NCT02211872	Completed	Drug: BI 2536 BS intravenous	Neoplasms	Boehringer Ingelheim	August 2004	Phase 1

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

常见问题及建议解决方法

问题 1：
We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?
回答：
For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

PLK Signaling Pathway Map

PLK Inhibitors with Unique Features

选择性强的Plk抑制剂

GSK461364 : Plk1-selective, K_i=2.2 nM.
用于临床的Plk抑制剂

Rigosertib (ON-01910) : Phase III for Myelo Dysplastic Syndrome (MDS).
最新的Plk抑制剂

Ro3280 ^New : Potent, highly selective inhibitor of Polo-like kinase 1 (PLK1) with IC50 of 3 nM.
经典的Plk抑制剂

Volasertib (BI 6727) : Highly potent Plk1 inhibitor with IC50 of 0.87 nM and in phase II trials.

研究领域

产品类型

定制您的化合物库

BI 2536

客户使用Selleck生产的BI 2536发表文献241篇：

产品安全说明书

PLK抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download BI 2536 SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

临床试验信息 (data from https://clinicaltrials.gov, updated on 2021-09-06)

技术支持

常见问题及建议解决方法

PLK Signaling Pathway Map

PLK Inhibitors with Unique Features

相关PLK产品