BI 2536

For research use only. Not for use in humans.

目录号：S1109

CAS No. 755038-02-9

BI-2536是一种有效的Plk1抑制剂，无细胞试验中IC50为0.83 nM。BI-2536可抑制 Bromodomain 4 (BRD4) ，其Kd值为37 nM，并有效地抑制 c-Myc 的表达。BI-2536可诱导凋亡而减弱自噬。Phase 2。

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10mM (1mL in DMSO)	RMB 1978.87	现货
5mg	RMB 981.57	现货
50mg	RMB 5492.59	现货
100mg	RMB 8160.83	现货
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客户使用Selleck生产的BI 2536发表文献257篇：

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产品安全说明书

PLK抑制剂选择性比较

生物活性

产品描述

特性

BI 2536是第一个有效的Plk1选择性抑制剂，抑制 Plk1的标记。

靶点

c-Myc ^[3] ()	PLK1 ^[1] (Cell-free assay)	PLK2 ^[1] (Cell-free assay)	PLK3 ^[1] (Cell-free assay)	BRD4 ^[3] (Cell-free assay)
	0.83 nM	3.5 nM	9.0 nM	37 nM(Kd)

体外研究

除了Plk1, BI 2536也抑制 Plk2 和Plk3活性，只是抑制程度低点,IC50分别为3.5 nM和9.0 nM。BI 2536比一组63种其他蛋白激酶（IC50>10 μM）选择性高1000多倍。BI 2536 按10 nM 到 100 nM剂量作用于HeLa细胞，抑制有丝分裂中心体中γ-微管蛋白招募和Apc6 磷酸化，抑制染色体臂中释放黏结蛋白, 诱导产生单极主轴，及一些依赖Plk1的其他有丝分裂过程。与作用于Plk1 RNAi效果相一致, BI 2536处理HeLa细胞，使细胞周期停在G2/M期, 随后DNA分解及凋亡，且累积断裂的PARP p85片段，这种作用存在浓度依赖性。BI 2536抑制一组32种人肿瘤细胞系生长，EC50为2-25 nM,抑制指数生长的hTERT-RPE1,人脐静脉内皮细胞 (HUVECs),和正常大鼠肾脏(NRK) 细胞的增殖，EC50为12-31 nM。^[1] BI 2536 抑制Plk1，降低甲状腺未分化癌(ATC)细胞如 CAL62, OCUT-1, SW1736, 8505C,和 ACT-1 的生长的生长和活力，EC50为1.4-5.6 nM。^[2]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
PSN1	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Mn76TWM2OD1yLkCwO\|c3KM7:TR?=	MlqyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
ACN	NW\re5FYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MY\JR\|UxRTBwMEC4OFMh\|ryP	NWrTRWtERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
TE-8	M4\5N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXzJR\|UxRTBwMEC5OFEh\|ryP	NInTTFY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
LC-2-ad	NGrl[JBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXLJR\|UxRTBwMEGwPVMh\|ryP	NVu4UFdyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
ALL-PO	NFq1b\|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NYfMOlhwUUN3ME2wMlAyOyEQvF2=	M2fZXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
EW-16	M1fiT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MV;JR\|UxRTBwMEGzN\|Yh\|ryP	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
KM12	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NEfoXJZKSzVyPUCuNFE{PDhizszN	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
GI-1	NIjyXllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVTK[ZN5UUN3ME2wMlAyOzh\|IN88US=>	MoHtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
LS-411N	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUjJR\|UxRTBwMEG0NFch\|ryP	NUnVOoFsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
ES8	NVXrSVU1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{LyUGlEPTB;MD6wNVQ6PCEQvF2=	NF3Qb4M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
SNU-C2B	MmnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M{ezNWlEPTB;MD6wNVUzPiEQvF2=	NV3DV3F4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
CESS	NV\NT2ZnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{H5dWlEPTB;MD6wNVYxOiEQvF2=	NFTNd249[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
697	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M17RNGlEPTB;MD6wNVY3QCEQvF2=	NHz3dHk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NCI-H1963	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NV65cW1qUUN3ME2wMlAyPjd\|IN88US=>	NH3PcIc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
IA-LM	NFi5W3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVjYcI9qUUN3ME2wMlAyPjh6IN88US=>	MoXEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
SW954	NXnuTIkyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnuwTWM2OD1yLkCxO\|A2KM7:TR?=	NVjNNXRORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
RL95-2	MknrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2HPemlEPTB;MD6wNVc{QCEQvF2=	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
LXF-289	M4LmR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MWPJR\|UxRTBwMEG3O{DPxE1?	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
OCUB-M	NHLhdYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Moj1TWM2OD1yLkCxPFI3KM7:TR?=	NFm5VJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
RKO	M2fEOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1TOZWlEPTB;MD6wNVk5PyEQvF2=	M4jCNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
LOUCY	NX7jcGtuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUTLRnNTUUN3ME2wMlAzODVizszN	NHfmSFk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NOS-1	NUXD[pNLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHO0[m5KSzVyPUCuNFIxQTNizszN	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
A4-Fuk	NEDUbZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M{XJZmlEPTB;MD6wNlIyQCEQvF2=	MlK4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
A388	M2DPU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Ml3uTWM2OD1yLkCyNlI4KM7:TR?=	MkjRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
TE-9	NUezeGdET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M4HxfmlEPTB;MD6wNlI3OSEQvF2=	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
KURAMOCHI	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NGThdlBKSzVyPUCuNFIzQDVizszN	M1TuWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
KALS-1	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NHHBZZhKSzVyPUCuNFI{OzhizszN	M2jOe\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
HOP-62	NGizWW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2jaWWlEPTB;MD6wNlQzKM7:TR?=	Mn63QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
RPMI-8402	NIj4cGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWe5dlQ6UUN3ME2wMlAzPTB6IN88US=>	MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
TE-1	M4nOZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1rXWmlEPTB;MD6wNlUyOiEQvF2=	MmHqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
CCRF-CEM	NVLMOI5sT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NWm3c5c2UUN3ME2wMlAzPTR\|IN88US=>	NIDZNIY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
HUTU-80	NXvzVmVrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2n6fGlEPTB;MD6wNlYzPCEQvF2=	NHqzNI09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NCI-H1648	NHvVd3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVfjXW5KUUN3ME2wMlAzPjR5IN88US=>	NVrz[FhVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
HCE-4	M4exXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MlLyTWM2OD1yLkCyOlgzKM7:TR?=	M4fwZ\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
ETK-1	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Moj6TWM2OD1yLkCyO\|M3KM7:TR?=	NEXFd3c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
TE-15	M4PoWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NXrGcGI3UUN3ME2wMlAzPzN6IN88US=>	MoXmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
BE-13	NHe3NI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MkXNTWM2OD1yLkCyO\|Qh\|ryP	NF;xZo89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
KE-37	M2DaWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NIGxb5VKSzVyPUCuNFI4PDFizszN	NELsVHQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NCI-H1355	M4Lw[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYLJR\|UxRTBwMEK3PFMh\|ryP	NHzLOHo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
TE-11	M1LMeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NI\VS5NKSzVyPUCuNFI5ODlizszN	Mk\nQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
BL-70	M{TlSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MomxTWM2OD1yLkCyPFU4KM7:TR?=	NGjqO3o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
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UACC-257	M1XTUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVq3XXBRUUN3ME2wMlE6QTR5IN88US=>	NEjNRlE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
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GAK	M1HIbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NWm0VVdMUUN3ME2wMlIyOTh7IN88US=>	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
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BC-1	M1vtXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NX7NbWZJUUN3ME2wMlIzPjF4IN88US=>	NEnBSGs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
SIG-M5	NUC0WXJoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MUDJR\|UxRTBwMkK3Nlch\|ryP	NXLHUpJSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NCI-H345	M3nuemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NI\Ed\|RKSzVyPUCuNlM5ODVizszN	MnHVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
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CTB-1	M1LsUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MkfhTWM2OD1yLkK0OFk{KM7:TR?=	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
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KARPAS-422	M2fXOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NUC4ZoIxUUN3ME2wMlI2PDN3IN88US=>	M4H1bFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
MEG-01	MoXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NXrXTIwxUUN3ME2wMlI2Pjd\|IN88US=>	MnWxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NCI-H209	NU\TSHl1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Ml:3TWM2OD1yLkK2N\|c1KM7:TR?=	NUD3Spg3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
SBC-1	NH7rOnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVj4eXhrUUN3ME2wMlI3PSEQvF2=	NVXwe5F7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
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NMC-G1	MorTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYPJR\|UxRTBwMkiyNVch\|ryP	M4P2[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
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MV-4-11	Mnm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M4rFd2lEPTB;MD6zNFc5QCEQvF2=	Mm\yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
LAN-6	NFfUXlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NX3I[3A2UUN3ME2wMlMyPTd{IN88US=>	NUHQ[Ws4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
RH-1	M{WzbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXLJR\|UxRTBwM{G4O\|Eh\|ryP	MkjGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
CP66-MEL	Mlr4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mn3LTWM2OD1yLkOxPFc5KM7:TR?=	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
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HDLM-2	NHXRZ3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NX\zWYxUUUN3ME2wMlM4QDF2IN88US=>	MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
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LB373-MEL-D	M4XZdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mn71TWM2OD1yLkO5NVk4KM7:TR?=	MoKzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
GOTO	NHv5d2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVLtcGhuUUN3ME2wMlQzOTF6IN88US=>	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
MRK-nu-1	Mn[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M{DjfGlEPTB;MD60NlIxPSEQvF2=	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
SK-MM-2	NFvleZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NHT2TGVKSzVyPUCuOFM1PDJizszN	M17YSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
BOKU	MnzNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MkfqTWM2OD1yLkSzO\|kzKM7:TR?=	NVzmdGpGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NOMO-1	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVXJR\|UxRTBwNEO4OkDPxE1?	NUHYWZFKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
J-RT3-T3-5	MoPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYTJR\|UxRTBwNES4O\|gh\|ryP	M1z2W\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
COLO-668	NULN[W9WT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1TsdWlEPTB;MD60OVY3QCEQvF2=	NF;tPW09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
SF539	MmDFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFPvdYJKSzVyPUCuOFg3QDRizszN	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
LB2518-MEL	NHjQe3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUPTbGZWUUN3ME2wMlQ6PzB\|IN88US=>	MnX4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
TE-441-T	NH3LXplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWTqNGJrUUN3ME2wMlUxOTJizszN	NUfNO212RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
MDA-MB-134-VI	NUDpOGJLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MkLiTWM2OD1yLkWwPVIyKM7:TR?=	NGjvNXo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
SCC-3	Mlz3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGW0bWhKSzVyPUCuOVE5PzNizszN	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
KLE	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnL3TWM2OD1yLkWyNVcyKM7:TR?=	M3vJelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
LB2241-RCC	NWrGSnVmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MkPtTWM2OD1yLkWyOVI2KM7:TR?=	NUnUfnNORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NCI-H1417	MmHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3HIRWlEPTB;MD61N\|Q{PSEQvF2=	NIXHc4U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NCI-H2081	MkDDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NWm4dnFwUUN3ME2wMlU5PjFzIN88US=>	MmL5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NCI-H1522	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NVTjb3NCUUN3ME2wMlU6Ozh\|IN88US=>	MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
NCI-H889	M13YN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NUD2NVZbUUN3ME2wMlU6QDR2IN88US=>	M4XDRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
CGTH-W-1	NF7LWmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFjmOIVKSzVyPUCuOlA4PTVizszN	NWLqT\|NHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
EB-3	NWXKVZVUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MV7JR\|UxRTBwNkGxOVMh\|ryP	NV34VolxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
D-336MG	MlPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVHUd4xPUUN3ME2wMlYyPzlzIN88US=>	MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
LC-1F	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Ml;QTWM2OD1yLk[yOVkzKM7:TR?=	MlnYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
MHH-NB-11	MonuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2SzOWlEPTB;MD62N\|gxOSEQvF2=	M1PXTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
SK-N-FI	MkfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NX33ZVE3UUN3ME2wMlY{QTFizszN	M1rMRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
NCI-H69	NXL4TGxrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M4n0cmlEPTB;MD62OFg4QSEQvF2=	MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
SCH	MkHkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Ml\LTWM2OD1yLk[2NFI{KM7:TR?=	NIDUOWU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
LS-513	MnXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NV\0NmlFUUN3ME2wMlY4OjV7IN88US=>	NGLsZWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
CP67-MEL	NHjFNphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mk\vTWM2OD1yLk[3OVk3KM7:TR?=	M1\ldVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
GCIY	M320dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MoDiTWM2OD1yLkewN\|Y{KM7:TR?=	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
SHP-77	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3vVdWlEPTB;MD63NFc{PCEQvF2=	NX;tTppyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
EHEB	MoDVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1jlZWlEPTB;MD63NVg2PCEQvF2=	NUjoUnRtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
D-247MG	MlnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2r5RWlEPTB;MD63N\|I{OiEQvF2=	M{jyU\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
Raji	M32xN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mn;iTWM2OD1yLke0PVg6KM7:TR?=	NVv1WJl5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
MPP-89	NGD2U2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MmGyTWM2OD1yLke1PVc5KM7:TR?=	NUfwO4FMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
EKVX	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFPGRohKSzVyPUCuO\|kxPzNizszN	NFHFdJM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
HCC2218	NHPPRnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXLJR\|UxRTBwN{mxN\|Eh\|ryP	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
KNS-81-FD	M1zjT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MlPlTWM2OD1yLkixNFEyKM7:TR?=	NHjGbJY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
HCC2157	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NXTufW9sUUN3ME2wMlg1QTVzIN88US=>	NVPSfVBxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
BT-474	NFjJPHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MV3JR\|UxRTBwOEi4OVQh\|ryP	NGjZSFk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NCI-H748	NIfrXY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXTHV5B[UUN3ME2wMlkyOiEQvF2=	NUDyemg1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
EW-24	M3vLNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2DlRmlEPTB;MD65NlAxOiEQvF2=	NX;HcVl4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
D-263MG	NEjGTnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVXJR\|UxRTBwOUS1NVIh\|ryP	NX7vN21iRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
OMC-1	Mn\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Ml\zTWM2OD1yLkm2N\|c{KM7:TR?=	NXHZSWV5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NCI-H2196	NF;O[IVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MoTNTWM2OD1yLkm3O\|c4KM7:TR?=	Mn;MQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
HAL-01	NEDMVodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3fmdmlEPTB;MD65PVg4OiEQvF2=	M3:0Z\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
NCI-H2107	NHPEfWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1nXWGlEPTB;MT6wNVg2PCEQvF2=	M324fFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
LB996-RCC	Ml[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MXjJR\|UxRTFwMEiwOVEh\|ryP	NXi3PY96RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NCI-H1395	M1rLT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mn;yTWM2OD1zLkGwOlch\|ryP	MmLJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
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CA46	NVPpPZlOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NF;uVmhKSzVyPUKuO\|U6PjdizszN	NX;OOHZ5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NCI-H23	M1rxSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFyzfI1KSzVyPUKuPFA4QTFizszN	M1vJVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
MMAC-SF	NIL0OoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3rDR2lEPTB;Mj64OlYzQCEQvF2=	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
NCI-H2171	NHm0[pJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3O5OmlEPTB;Mz6wN\|Q1QCEQvF2=	NFHjOFY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
A704	M2TTRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHLIXGlKSzVyPUOuNVQyQTRizszN	MmHCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
DB	NI[ye2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MoPUTWM2OD1\|LkK1OVc3KM7:TR?=	MkfHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NCI-H719	MoHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1;1N2lEPTB;Mz6zNFM5PCEQvF2=	MkS2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
MC-CAR	M1q5dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NIjPN41KSzVyPUOuOVQ5OTdizszN	Mn\TQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
SIMA	MmfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MU\JR\|UxRTNwNUi0NVYh\|ryP	NFjXZ2s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
SW872	NGDTO25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NF\VPJdKSzVyPUOuO\|gyODFizszN	M4m5fFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
HCC1187	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MWfJR\|UxRTNwN{izNVUh\|ryP	Mm\LQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
EW-13	NXS5d4lzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NWPqdY11UUN3ME2zMlg{PDF5IN88US=>	MmLSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NCI-SNU-1	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4jW[2lEPTB;ND6yNVk6QSEQvF2=	NWTQSI9RRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NCI-H226	NEfhbItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXy4S3k3UUN3ME20MlM{PjB4IN88US=>	MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
RPMI-8866	NYXMT5BkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M4nrVmlEPTB;ND6zOlAzQSEQvF2=	NXuyeYh5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
OCI-AML2	Mn7LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NIDFR5FKSzVyPUSuOVUzOyEQvF2=	NGLxXJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
LU-65	M3XyVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NG\NV2pKSzVyPUSuPVMxOzNizszN	NHWxNYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
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NB14	M{nW[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1nTRmlEPTB;NT65O\|E{PSEQvF2=	NGPjWpM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
COLO-829	NXnrXoNnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3;Q[WlEPTB;Nj6zN\|M2QSEQvF2=	NX3HPJR5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
MHH-CALL-2	NUXSOoZCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXLyWXNoUUN3ME22MlUyPTB6IN88US=>	MmHWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NCI-H1770	NW\IfYg2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NIixXGhKSzVyPU[uOlY6ODRizszN	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
ECC4	M4\BSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NWDlV3d[UUN3ME22MlgzOTd7IN88US=>	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
A498	M3HlTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NWfBOWxGUUN3ME22Mlg4OTl{IN88US=>	NF31[XA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
DMS-79	MkXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MWjJR\|UxRTdwMES1NVIh\|ryP	MlfxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
P30-OHK	NWfJWpBFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NYPF[FZUUUN3ME23MlIyQTB4IN88US=>	MkXnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
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RCC10RGB	M{DHbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mm\nTWM2OD16LkC2Nlgh\|ryP	M3HhfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
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BB49-HNC	MnH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1fybmlEPTB;OT60NlI3PSEQvF2=	NUXPO2RuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
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MFM-223	NFjwPW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUnyUlAzUUN3ME2xNE46QTJ5IN88US=>	NIK1e5M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
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MSTO-211H	MlnYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NITOXIRKSzVyPUKxMlg5PThizszN	NV3xdZhMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
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THP-1	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MoDLTWM2OD1{OT63NlAyKM7:TR?=	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
NB10	M1TZT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHnGVmFKSzVyPUOwMlI3QTRizszN	M4m0OVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
NH-12	M2nQXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4XrT2lEPTB;M{OuNlAyPyEQvF2=	M4nEfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
COLO-824	Mof1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVXXTItbUUN3ME2zOE4yODB4IN88US=>	NVTaTpNNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
SKM-1	NIGxW2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MmXVTWM2OD1\|Nz64OFIzKM7:TR?=	NH3oR2s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NCI-H1838	MkTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mn[1TWM2OD1\|OD6zO\|k4KM7:TR?=	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
RL	M4LJPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1u3emlEPTB;M{muNlQ4PyEQvF2=	MlXqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
COLO-800	MlexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1fLS2lEPTB;NECuNFc4OyEQvF2=	NU\MelJGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
KG-1	MlTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MoWzTWM2OD12MD64PVU2KM7:TR?=	MmTZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
TUR	NV24VnpGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M4PRSmlEPTB;NEGuOlM6QSEQvF2=	Mmm1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
LNCaP-Clone-FGC	NYG4coR[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mn3ETWM2OD12MT65NFE4KM7:TR?=	Mn3tQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NCI-H322M	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MYTJR\|UxRTR{LkW5PFQh\|ryP	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
LNCaP	NInS[GJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MlfGTWM2OD17MT6zJI5O	NIPBTVc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUWwOVE4PCd-MkW1NFUyPzR:L3G+
C4-2	MmmzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NH;1UGZKSzVyPUigcm0>	NF7vRVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUWwOVE4PCd-MkW1NFUyPzR:L3G+
JURKAT	M{G5Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		M3fHPVI1KGh?		NXPw[3l5UUN3ME20NVYvPjZibl2=	M3mwVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
MOLT-4	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		M3;hTFI1KGh?		MULJR\|UxRTJ6NUOuOUBvVQ>?	M4j2UVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
REH	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NYXIcYo1OjRiaB?=		NXH0cJd3UUN3ME2yPFcvPjhibl2=	NU\GSZRQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NVk6QTVpPkK0OVE6QTl3PD;hQi=>
NALM-6	NIS0TlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NWrJ[llmOjRiaB?=		NEnD[WZKSzVyPUO0N\|MxKG6P	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
RS 4;11	NYPMdVlbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MVeyOEBp		M4f4WGlEPTB;NUG5MlA2KG6P	M2X0TlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
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SIL-ALL	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		Mn;zNlQhcA>?		MkT3TWM2OD1zOUmuO\|chdk1?	M{LSNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
CEM	NIHuRoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		M3nOc\|I1KGh?		NUL6XZoyUUN3ME21Nk4yQCCwTR?=	M3XPU\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
P12	M4HDO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7		M{WxbVI1KGh?		MnKxTWM2OD1\|OT6yO{BvVQ>?	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
NALM-16	NFz2ZYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MmH4NlQhcA>?		MVjJR\|UxRTl4LkK4JI5O	MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
JURKAT	MmfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NHvmbVQ1QCCq		NV[5UYlzUUN3ME2xOE45PCCwTR?=	M1i0XFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
MOLT-4	NGfTTZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		M{fINlQ5KGh?		M2DOSWlEPTB;Mk[uOkBvVQ>?	NGf1NFc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
REH	MoCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		M1yzU\|Q5KGh?		NF61VJFKSzVyPUS0MlcyKG6P	MkL3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
NALM-6	NXO0bmZbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MmfJOFghcA>?		Mke1TWM2OD1{Mz6yOkBvVQ>?	M4rSZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
RS 4;11	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		M2jKeFQ5KGh?		M2jR[GlEPTB;MU[0MlI5KG6P	MnjrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
697	NUnFWW15T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MmPCOFghcA>?		MkWyTWM2OD1\|MEWuN{BvVQ>?	NFroWmI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
SIL-ALL	NHjVUJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MnntOFghcA>?		MUnJR\|UxRTd2Lk[yJI5O	M4XaO\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
CEM	Mn:1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MXe0PEBp		MYTJR\|UxRTJ2LkW1JI5O	MnLSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
P12	M4nIfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MnPHOFghcA>?		M{K3ZWlEPTB;MUiuOFYhdk1?	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
NALM-16	NHX6cnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		Mn7lOFghcA>?		NXvDbnFEUUN3ME22N{4zPCCwTR?=	Mnz6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
JURKAT	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		M1zySFczKGh?		NH7adJVKSzVyPUOuOlUhdk1?	NUTsXXdIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NVk6QTVpPkK0OVE6QTl3PD;hQi=>
MOLT-4	MkjlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NH\USYw4OiCq		MX;JR\|UxRTdwM{mgcm0>	Mk\yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
REH	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MkLqO\|IhcA>?		NEm0dJRKSzVyPUG2MlAyKG6P	M2fWOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
NALM-6	NGjMSHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		M2TlflczKGh?		NVPueXZkUUN3ME2xMlc5KG6P	MmO0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
RS 4;11	NIe3RY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		M4nRWlczKGh?		NFzZW4RKSzVyPUSuN\|ghdk1?	NYexS2d5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NVk6QTVpPkK0OVE6QTl3PD;hQi=>
697	M134UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		M4rIeVczKGh?		MnTwTWM2OD15ND6yPEBvVQ>?	NYPx[W9jRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NVk6QTVpPkK0OVE6QTl3PD;hQi=>
SIL-ALL	M2mxVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NGS5Tm84OiCq		MnLtTWM2OD15LkKgcm0>	NHWzepM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
CEM	M{DMZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NWrzVIdHPzJiaB?=		MnPZTWM2OD13LkSyJI5O	M3PkclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
P12	M{\3Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		Mo\kO\|IhcA>?		NUXFRVVnUUN3ME22MlM4KG6P	NF[yVo09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
NALM-16	M2PCR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MoLpO\|IhcA>?		NWPLS4NpUUN3ME23O{44OyCwTR?=	NHe0Smg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
Y79	NUL6[Y5tSXCxcITvd4l{KEG\|c3H5	NVL5VZNlOS13MDDuUS=>	NEHtepMyOi9{NDDo	MVjEUXNQ	M1PPT4lv\HWlZXSgZZBweHSxc3nzJJdpcWOqIHPhckBj\SCnbnjhcoNm\CCkeTDIWC=>	M3Hxe\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{[2OlY2Lz5{NEO2OlY3PTxxYU6=
WER-Rb-1	MknaRZBweHSxc3nzJGF{e2G7	NYrRN2c3OS13MDDuUS=>	M4X1eFEzNzJ2IHi=	NFnSTopFVVOR	NEDrfYtqdmS3Y3XkJIFxd3C2b4Ppd{B4cGmlaDDjZY4h[mViZX7oZY5k\WRiYomgTHQ>	M13Qe\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{[2OlY2Lz5{NEO2OlY3PTxxYU6=
G7	NVzzOGpGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXPm[2JrUUN3ME2zMlMhdk1?	MkPoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{MES3N\|MoRjJ2MkC0O\|M{RC:jPh?=
G166	M131[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVPJR\|UxRTdwMDDuUS=>	NWXCT4VJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyNFQ4OzNpPkK0NlA1PzN\|PD;hQi=>
CB660	NU[2cFFoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{m4SmlEPTB;Nj60JI5O	M4noblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MkC0O\|M{Lz5{NEKwOFc{OzxxYU6=
CB1117	M2PpUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVfJR\|UxRTF3Lk[gcm0>	Ml;PQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{MES3N\|MoRjJ2MkC0O\|M{RC:jPh?=
KB-3-1	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MXPJR\|UxRTFwNEigxtEhOC53MzDuUS=>	MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4MkS0OUc,OjN7NkK0OFU9N2F-
KB-8-5-11	M3zqeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2rm[mlEPTB;NT6wNUDDuSB{LkCxJI5O	NGDaUXc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2NlQ1PSd-MkO5OlI1PDV:L3G+
KB-C-1	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NX;VToNxUUN3ME2xOk44PiEEsTC0MlUyKG6P	MmHlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkK0OFUoRjJ\|OU[yOFQ2RC:jPh?=
KB-V-1	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NGXyS\|ZKSzVyPUK4NU4zPCEEsTCzNU42PyCwTR?=	MlXrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkK0OFUoRjJ\|OU[yOFQ2RC:jPh?=
OVCAR-8	NFrMUnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MmrGTWM2OD15LkG5JOKyKDNwNkCgcm0>	NWHMb\|BWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5OlI1PDVpPkKzPVYzPDR3PD;hQi=>
NCI-ADR-RES	NUDvcIlIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHzYN5lKSzVyPUGyO\|MvOzBiwsGgNVkyNjJyIH7N	MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4MkS0OUc,OjN7NkK0OFU9N2F-
MCF7	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MoPsTWM2OD13LkGxJOKyKDFwNEegcm0>	NGD6eIM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2NlQ1PSd-MkO5OlI1PDV:L3G+
MCF7-FLV1000	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmPxTWM2OD1\|OUOuNVghyrFiN{SuPFMhdk1?	NVXBeW44RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5OlI1PDVpPkKzPVYzPDR3PD;hQi=>
S1	NVXCT2dLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnPZTWM2OD1{ND6zNEDDuSB2Lke1JI5O	Mm\iQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkK0OFUoRjJ\|OU[yOFQ2RC:jPh?=
S1-M1-80	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MX\JR\|UxRTJ4MT6wOkDDuSB2OD6yOUBvVQ>?	MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4MkS0OUc,OjN7NkK0OFU9N2F-
CORL-23/P	NFe5SYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NGTqfotKSzVyPUSuN\|ghyrFiMT6yOUBvVQ>?	NYSwTWg6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5OlI1PDVpPkKzPVYzPDR3PD;hQi=>
CORL-23/R	NF3z[nBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1Xu[WlEPTB;NT6xOkDDuSBzLkizJI5O	Mo[yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkK0OFUoRjJ\|OU[yOFQ2RC:jPh?=
NIH3T3	NFvvbmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVSxZnd5UUN3ME20NE43OCEEsTC0Mlk4KG6P	MkLjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkK0OFUoRjJ\|OU[yOFQ2RC:jPh?=
NIH3T3-G185	M1myeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MkLYTWM2OD1{NEGzMlQxKMLzIESyN{43PiCwTR?=	Mme4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkK0OFUoRjJ\|OU[yOFQ2RC:jPh?=
pcDNA-HEK293	M2P5bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MnS2TWM2OD1{Lke1JOKyKDBwNkegcm0>	MnjRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkK0OFUoRjJ\|OU[yOFQ2RC:jPh?=
MDR19-HEK293	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M1PSS2lEPTB;OEWuOVAhyrFiMUOuOlchdk1?	NYHMSoMxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5OlI1PDVpPkKzPVYzPDR3PD;hQi=>
R482-HEK293	NIHXOWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3;tXWlEPTB;MkWuPVchyrFiND65OUBvVQ>?	MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4MkS0OUc,OjN7NkK0OFU9N2F-
MRP1-HEK293	M{DLcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MnzZTWM2OD1{Lkm5JOKyKDFwNEmgcm0>	MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4MkS0OUc,OjN7NkK0OFU9N2F-
SF188	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2[3ZVExNTFyMDDuUS=>	M2r1V\|I1NTl4IHi=	MYnEUXNQ	NVe5VHJycW6qaXLpeJMh[2WubDDndo94fGhiaX6gZo91cCC2aX3lMUBidmRiY3;uZ4VvfHKjdHnvck0h\GWyZXTlcpQhdWGwbnXy	M3vHPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OEi3OlQ2Lz5{M{i4O\|Y1PTxxYU6=
T98G	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3zacFExNTFyMDDuUS=>	MYKyOE06PiCq	MUDEUXNQ	MXnpcohq[mm2czDj[YxtKGe{b4f0bEBqdiClb37j[Y51emG2aX;uMUBl\XCnZHXueEBu[W6wZYK=	NWDTS2tkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4PFc3PDVpPkKzPFg4PjR3PD;hQi=>
DU145	MnLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			M3nyT2ROW09?	MnTiTWM2OOLKvE[wJI5O	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzh6NESyPEc,OjN6OES0Nlg9N2F-
LNCaP	NG\YWGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MkDhSG1UVw>?	MYXJR\|Ux6oj:N{Wgcm0>	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzh6NESyPEc,OjN6OES0Nlg9N2F-
PC3	MkjzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NWnlV5RITE2VTx?=	MXHJR\|Ux6oj:MUe1JI5O	NWPDRW8yRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4PFQ1OjhpPkKzPFg1PDJ6PD;hQi=>
RT4	MnHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYPJR\|UxRTJ5LkKxJI5O	NUL2flF{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO3PVI3OzlpPkKzO\|kzPjN7PD;hQi=>
5637	NY[3OFZwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NV7MdJBJUUN3ME20OU41PyCwTR?=	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd7Mk[zPUc,OjN5OUK2N\|k9N2F-
T24	NF7PcHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NHXJTpdKSzVyPUe5MlEzKG6P	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd7Mk[zPUc,OjN5OUK2N\|k9N2F-
MCF7	NVLmO2xQTnWwY4Tpc44hSXO\|YYm=	NYXYfJd3OTByIH7N	M3vvR\|EhcA>?	M1PGfWROW09?	MULy[YR2[2W\|IITo[UBqdmS3Y4Tpc44hd2cEoFfy[YIyNMLiU3frNUzDqFC\|Mj\|CpHNmenCrbnGzMEBidmUEoGfpd5Az	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd5MEK0OEc,OjN5N{CyOFQ9N2F-
KB-V1	NHPEcIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4LHTWlEPTB;Mz65NkDPxE1?	MknOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3OUOxPVYoRjJ\|NUmzNVk3RC:jPh?=
Hec50co	NHjpfHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MV3JR\|UxRTVibl2=	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzF2Nk[4O{c,OjNzNE[2PFc9N2F-
MDA-MB-468	NFPqfnpCeG:ydH;zbZMhSXO\|YYm=	MlLaNU82NzFyIH7N	M4PneVI1NzR6L{eyJIg>	NFnXUmFFVVOR	MWPpcoR2[2W\|IHHwc5B1d3OrczDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?=	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzF2NEK5OEc,OjNzNESyPVQ9N2F-
MCF10A	MYrBdI9xfG:\|aYOgRZN{[Xl?	MXSxM\|UwOTBibl2=	MWSyOE81QC95MjDo	M3fa[WROW09?	NISzOXpqdmS3Y3XzJIFxd3C2b4Ppd{BqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=>	MmDIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNzNESyPVQoRjJ\|MUS0Nlk1RC:jPh?=
Huh-7	NIeyeVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Moi5NU8yOC9zMECvNVAxOCCwTR?=	NITuRY01QCCq		Mni0[IVkemWjc3XzJJRp\SClZXzsJJZq[WKrbHn0fUBld3OnLXTldIVv\GWwdHz5	NEDIS3o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mke0OVU5Pyd-MkK3OFU2QDd:L3G+
Daoy	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlfxNU45PzVvMkSwJI5O	NH;SOI04OiCq	NWjEUG97TE2VTx?=	MWLJR\|UxRTVibl2=	MmTVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ\|OUCyO\|koRjJ{M{mwNlc6RC:jPh?=
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BT-12	NYnSdlhXeUiWUzDhd5NigQ>?				M3W2T5FJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCEVD2xNkBk\Wyucx?=	NXn0U2xjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
NB1643	NX7JRmVYeUiWUzDhd5NigQ>?				NYD0W\|A6eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IF7CNVY1OyClZXzsdy=>	NGL2dZo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
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LAN-5	NF:1cmtyUFSVIHHzd4F6				M2HxSZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCOQV6tOUBk\Wyucx?=	NUfOUYh[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
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NB1643	MV;xTHRUKGG\|c3H5				MUTxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDORlE3PDNiY3XscJM>	NX:1fFU{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
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Saos-2	NXzWWWp7eUiWUzDhd5NigQ>?				NFyzU2lyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBU[W:\|LUKgZ4VtdHN?	NYHoco9XRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
DU145	MVrBdI9xfG:\|aYOgZZN{[Xl?	MUixNFAhdk1?	M4Luc\|I1KGi{cx?=		MnfRTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCGVUG0OUBk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCSQWLQJINt\WG4YXflJIF1KDFyMDDuUUBi\nSncjCyOEBpenNiYomgbY1ufW6xYnzveJRqdmdibXX0bI9l	NU\RO2JnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2PFU6PDFpPkK1Olg2QTRzPD;hQi=>
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DU145	Moj6SpVv[3Srb36gZZN{[Xl?	M3e3cFExOCCwTR?=			MlvpTY5pcWKrdHnvckBw\iCSTFuxJJBzd3SnaX6gZYNkfW23bHH0bY9vKGmwIHj1cYFvKESXMUS1JINmdGy\|IHH0JFExOCCwTTDifUBqdW23bn;icI91fGmwZzDt[ZRpd2R?	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ6NUm0NUc,OjV4OEW5OFE9N2F-
HeLa	MoPVSpVv[3Srb36gZZN{[Xl?	MX6xNFAhdk1?			MVnJcohq[mm2aX;uJI9nKFCOS{GgdJJwfGWrbjDhZ4N2dXWuYYTpc44hcW5iaIXtZY4hUGWOYTDj[YxteyCjdDCxNFAhdk1iYomgbY1ufW6xYnzveJRqdmdibXX0bI9l	M2LwbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Nki1PVQyLz5{NU[4OVk1OTxxYU6=
HeLa	M1HTW2Z2dmO2aX;uJIF{e2G7	M4XmSFExOCCwTR?=	MVKxPEBpenN?		MYnJcoR2[3Srb36gc4YhdW:wb4DvcIFzKG2rdH;0bYMhe3CrbnTs[ZMhcW5iaIXtZY4hUGWOYTDj[YxteyCjdDCxNFAhdk1iaX7jeYJifGWmIH\vdkAyQCCqcoOgZpkhcW6maYLlZ5QhcW2vdX7v[ox2d3Knc3PlcoNmKG2rY4Lvd4NweHl?	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ6NUm0NUc,OjV4OEW5OFE9N2F-
HeLa	Mk\CRZBweHSxc3nzJIF{e2G7	MmfhNVAxKG6P	MlzYNlQhcHK\|		MkTuTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCKZVzhJINmdGy\|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKFCDUmCgZ4xm[X[jZ3WgZZQhOTByIH7NJIFnfGW{IEK0JIhzeyCkeTDpcY12dm:kbH;0eIlv\yCvZYToc4Q>	M3vUclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Nki1PVQyLz5{NU[4OVk1OTxxYU6=
PC3	MWjGeY5kfGmxbjDhd5NigQ>?	M{jM[VExOCCwTR?=	Mk\nNVghcHK\|		NHLzWnlKdmS3Y4Tpc44hd2ZibX;uc5BwdGG{IH3peI91cWNic4DpcoRt\XNiaX6gbJVu[W5iUFOzJINmdGy\|IHH0JFExOCCwTTDpcoN2[mG2ZXSg[o9zKDF6IHjyd{BjgSCrbnTpdoVkfCCrbX31co9ndHWxcnXzZ4Vv[2VibXnjdo9{[2:yeR?=	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ6NUm0NUc,OjV4OEW5OFE9N2F-
DU145	MUTGeY5kfGmxbjDhd5NigQ>?	NVf3fFhwOTByIH7N			NW\oW4VUUW6qaXLpeIlwdiCxZjDQUGsyKFSqckKxNEBxcG:\|cHjvdplt[XSrb36gbY4hcHWvYX6gSHUyPDViY3XscJMh[XRiMUCwJI5OKGK7IHntcZVvd2Kub4T0bY5oKG2ndHjv[C=>	NV\iPI1lRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2PFU6PDFpPkK1Olg2QTRzPD;hQi=>

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	pro-caspase-8 / cleaved caspase-8 / cleaved caspase-3 / cleaved caspase-9; PubMed: 27699933 Cancer Sci PLKi‐induced caspase activation. HeLa cells were treated with BI 2536 (10 nmol/L), BI 6727 (68 nmol/L), or GSK461364 (11 nmol/L), and HCT 116 cells were treated with BI 2536 (20 nmol/L), BI 6727 (70 nmol/L), or GSK461364 (12 nmol/L) for 48 h. The levels of cleaved caspase (CASP)‐3, ‐8, and ‐9 were examined by Western blot analysis. p-HH3 / PARP / Myc / p-Myc; PubMed: 24771642 Clin Cancer Res Western blotting showing more mitotic arrested (shown by phospho-histone H3) and apoptotic (shown by PARP) cells as well as lower MYC levels in LNCaP-Pim1 cells after BI 2536 treatment compared with LNCaP-Neo cells. The difference is obvious at lower dose of BI 2536 (10 nM). Both total MYC expression and phosphor-MYC levels were lower in Pim1 cells than Neo cells after BI 2536 treatment. pMEK / MEK / pERK / ERK / pRSK1 / RSK1; PubMed: 28430578 Oncotarget (A) and (B) Western blot analysis of the expression and activation of components of the MEK-ERK-RSK1 pathway in MKN45 and MKN74 cancer cells treated with BI 2536 and BI 6727 for 24 and 48 hours, respectively. pPlk1 / Plk1 / pMyt1; PubMed: 28430578 Oncotarget (A) and (B) Western blot analysis of the expression and phosphorylation of Plk1, and phosphorylation of Myt1 in the CSC-like and cancer cells after treatment with BI 2536 and BI 6727 for 24 and 48 hours, respectively. Aurora B / pAurora B / pAurora C / pH3 / Cyclin B1 / Securin / pBcl-XL / MPM2; PubMed: 25169932 Mol Oncol Western blot analysis of cells treated for 24 h with the indicated inhibitor concentrations. Cell lysates were immunoblotted for Plk1, Phospho-Aurora B (T232)/Aurora C (T198), Aurora B, histone H3 phosphorylated at S10 (pH3), Cdk1, Cyclin B1, Securin, Phospho-Bcl-XL, Induced myeloid leukemia cell differentiation protein Mcl-1, MPM-2 and β-Actin. Left (Hela cells); Right (HUVEC)	27699933 24771642 28430578 25169932
Immunofluorescence	p-H2AX / propidium iodide; PubMed: 22309939 Breast Cancer Res Apoptotic images of the cells after BI 2536 treatment, as revealed by HCS (high-content screening) instrument (×10) with phospho-H2AX antibody or PI (propidium iodide) intake. Pericentrin / α-tubulin; PubMed: 21772266 Nat Commun MEFs were labelled using Plk1, pericentrin and α-tubulin antibodies and 4,6-diamidino-2-phenylindole for the analysis by immunofluorescence microscopy. Representative examples of BI 2536-treated and control MEFs are depicted. Scale bar, 5 μm.	22309939 21772266
Growth inhibition assay	Cell viability; PubMed: 21772266 Nat Commun Proliferative activity of MEFs at different BI 2536 concentrations (25–250 nM; means±s.d., n=3, for each concentration). P<0.05, P<0.01, **P<0.001, Student's t-test, unpaired and two-tailed.	21772266

体内研究

BI 2536静脉注射给药多种移植瘤模型，每周一次或两次，效果都很好，通过使细胞周期停滞而抑制细胞增殖，随后诱导肿瘤细胞死亡。BI 2536按 50 mg/kg剂量处理HCT 116移植瘤，每周一次或两次，显著抑制肿瘤生长，T/C 分别为15%和0.3%。BI 2536每周处理两次BxPC-3和A549模型，也显著抑制肿瘤生长，T/C分别为5% 和14%。^[1]

激酶实验： ^[1]	- 合并体外Plk1激酶实验: 重组人Plk1 (1-603残基) 作为氮端，携带杆状病毒表达系统的GST-标记的融合蛋白通过亲和层析，使用谷胱甘肽-琼脂糖而纯化。在梯度稀释的BI 2536存在时，使用 20 ng 重组激酶，及10 μg牛奶中的酪蛋白作为底物进行Plk1 酶活性实验。在终体积为60 μL 的混合物(15 mM MgCl₂, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-³³P-ATP)中30^oC下进行激酶反应45分钟。加入 125 μL 冰冻的5% TCA终止反应。沉淀物转移到混合酯纤维素的多屏过滤板上，使用1% TCA冲洗实验板，然后利用放射性进行测量。绘制剂量反应曲线，而计算IC50值。
细胞实验： ^[1]	- 合并 Cell lines: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji, PC-3,等等 Concentrations: 溶于DMSO, 终浓度为~1 μM Incubation Time: 24,和72小时 Method: 使用不同浓度BI 2536处理细胞24和72小时。在荧光分光光度计中测量Alamar Blue染料转换而测定细胞生长。为了测定培养基中DNA含量，细胞悬液在80%乙醇中混合, 使用溶于PBS的0.25% Triton X-100处理5分钟，然后与0.1% RNase 和溶于PBS的 10 μg/mL碘化丙啶在室温下温育20分钟。通过流式细胞仪分析而测定细胞周期谱。 (Only for Reference)
动物实验： ^[1]	- 合并 Animal Models: 皮下注射HCT 116, NCI-H460, 或A549 细胞的雌性BomTac:NMRI-Foxn1nu 小鼠 Dosages: ~50 mg/kg Administration: 静脉注射，每周一到两次 (Only for Reference)

参考文献

溶解度 (25°C)

体外	Ethanol	100 mg/mL (191.69 mM)
	DMSO	21 mg/mL (40.25 mM)
	Water	Insoluble
体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： 5%DMSO+40%PEG300+5%Tween80+50%ddH2O	12.5mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download BI 2536 SDF

分子量	521.66
化学式	C₂₈H₃₉N₇O₃
CAS号	755038-02-9
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	N/A

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

临床试验信息 (data from https://clinicaltrials.gov, updated on 2022-01-17)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT02215044	Terminated	Drug: BI 2536 intravenous\|Drug: Gemcitabine intravenous	Pancreatic Neoplasms	Boehringer Ingelheim	June 2007	Phase 1
NCT02211833	Completed	Drug: BI 2536\|Drug: Pemetrexed	Carcinoma Non-Small-Cell Lung	Boehringer Ingelheim	October 2006	Phase 1
NCT00701766	Completed	Drug: BI 2536	Leukemia Myeloid Acute	Boehringer Ingelheim	October 2006	Phase 2
NCT00706498	Completed	Drug: BI 2536	Prostatic Neoplasms	Boehringer Ingelheim	September 2006	Phase 2
NCT00376623	Completed	Drug: BI 2536	Carcinoma Non-Small-Cell Lung	Boehringer Ingelheim	July 2006	Phase 2
NCT02211872	Completed	Drug: BI 2536 BS intravenous	Neoplasms	Boehringer Ingelheim	August 2004	Phase 1

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

常见问题及建议解决方法

问题 1：
We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?
回答：
For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

PLK Signaling Pathway Map

PLK Inhibitors with Unique Features

选择性强的Plk抑制剂

GSK461364 : Plk1-selective, K_i=2.2 nM.
用于临床的Plk抑制剂

Rigosertib (ON-01910) : Phase III for Myelo Dysplastic Syndrome (MDS).
最新的Plk抑制剂

Ro3280 ^New : Potent, highly selective inhibitor of Polo-like kinase 1 (PLK1) with IC50 of 3 nM.
经典的Plk抑制剂

Volasertib (BI 6727) : Highly potent Plk1 inhibitor with IC50 of 0.87 nM and in phase II trials.

研究领域

产品类型

定制您的化合物库

BI 2536

客户使用Selleck生产的BI 2536发表文献257篇：

产品安全说明书

PLK抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download BI 2536 SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

临床试验信息 (data from https://clinicaltrials.gov, updated on 2022-01-17)

技术支持

常见问题及建议解决方法

PLK Signaling Pathway Map

PLK Inhibitors with Unique Features

相关PLK产品