BI 2536

For research use only. Not for use in humans.

目录号:S1109

BI 2536 Chemical Structure

Molecular Weight(MW): 521.66

BI 2536是一种有效的Plk1抑制剂,无细胞试验中IC50为0.83 nM,比作用于Plk2和Plk3选择性分别高4和11倍。Phase 2。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1978.87 现货
RMB 981.57 现货
RMB 1704.35 现货
RMB 5492.59 现货
RMB 8160.83 现货
有超大折扣

今日订购,明日送达,全国免运费!

全国免费电话:400-668-6834   |   Email:info@selleck.cn

客户使用Selleck生产的BI 2536发表文献134篇:

产品安全说明书

PLK抑制剂选择性比较

生物活性

产品描述 BI 2536是一种有效的Plk1抑制剂,无细胞试验中IC50为0.83 nM,比作用于Plk2和Plk3选择性分别高4和11倍。Phase 2。
特性 BI 2536是第一个有效的Plk1选择性抑制剂,抑制 Plk1的标记。
靶点
PLK1 [1]
(Cell-free assay)
PLK2 [1]
(Cell-free assay)
PLK3 [1]
(Cell-free assay)
0.83 nM 3.5 nM 9.0 nM
体外研究

除了Plk1, BI 2536也抑制 Plk2 和Plk3活性,只是抑制程度低点,IC50分别为3.5 nM和9.0 nM。BI 2536比一组63种其他蛋白激酶(IC50>10 μM)选择性高1000多倍。BI 2536 按10 nM 到 100 nM剂量作用于HeLa细胞,抑制有丝分裂中心体中γ-微管蛋白招募和Apc6 磷酸化,抑制染色体臂中释放黏结蛋白, 诱导产生单极主轴,及一些依赖Plk1的其他有丝分裂过程。与作用于Plk1 RNAi效果相一致, BI 2536处理HeLa细胞,使细胞周期停在G2/M期, 随后DNA分解及凋亡,且累积断裂的PARP p85片段,这种作用存在浓度依赖性。BI 2536抑制一组32种人肿瘤细胞系生长,EC50为2-25 nM,抑制指数生长的hTERT-RPE1,人脐静脉内皮细胞 (HUVECs),和正常大鼠肾脏(NRK) 细胞的增殖,EC50为12-31 nM。[1] BI 2536 抑制Plk1,降低甲状腺未分化癌(ATC)细胞如 CAL62, OCUT-1, SW1736, 8505C,和 ACT-1 的生长的生长和活力,EC50为1.4-5.6 nM。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PSN1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\4TWM2OD1yLkCwO|c3KM7:TR?= NVnNbZdjW0GQR1XS
ACN M2e1SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2juWGlEPTB;MD6wNFg1OyEQvF2= MV;TRW5ITVJ?
TE-8 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PSXWlEPTB;MD6wNFk1OSEQvF2= M3HtdHNCVkeHUh?=
LC-2-ad MlXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTUTWM2OD1yLkCxNFk{KM7:TR?= NVnqd5llW0GQR1XS
ALL-PO MljaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHlcHB7UUN3ME2wMlAyOyEQvF2= MnfSV2FPT0WU
EW-16 NFjrd4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUWwNJc2UUN3ME2wMlAyOzN4IN88US=> MonUV2FPT0WU
KM12 MlXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzmTFZKSzVyPUCuNFE{PDhizszN NFjKU4NUSU6JRWK=
GI-1 NGjxfWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwMEGzPFMh|ryP MVPTRW5ITVJ?
LS-411N NY\aWGIzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHucoxRUUN3ME2wMlAyPDB5IN88US=> NXfIfY1KW0GQR1XS
ES8 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwMEG0PVQh|ryP NXLtcIhLW0GQR1XS
SNU-C2B M1myUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mle2TWM2OD1yLkCxOVI3KM7:TR?= MoruV2FPT0WU
CESS Mm\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILjT3JKSzVyPUCuNFE3ODJizszN M3LLeHNCVkeHUh?=
697 MnX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nUTWlEPTB;MD6wNVY3QCEQvF2= Mki2V2FPT0WU
NCI-H1963 NYe4dGFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fSRWlEPTB;MD6wNVY4OyEQvF2= MV7TRW5ITVJ?
IA-LM NXTOPJpsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfOOVNKSzVyPUCuNFE3QDhizszN M2e1U3NCVkeHUh?=
SW954 MlvnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTBwMEG3NFUh|ryP NXTjeZlxW0GQR1XS
RL95-2 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUexUG55UUN3ME2wMlAyPzN6IN88US=> MkLiV2FPT0WU
LXF-289 M4XVPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTBwMEG3O{DPxE1? NYXBfmxqW0GQR1XS
OCUB-M NXzsSnNUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnqyTWM2OD1yLkCxPFI3KM7:TR?= NHHTRYtUSU6JRWK=
RKO NWPibmp{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPwVZZKSzVyPUCuNFE6QDdizszN MUHTRW5ITVJ?
LOUCY MoTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV22fGJNUUN3ME2wMlAzODVizszN NWrBdY1WW0GQR1XS
NOS-1 MoixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTBwMEKwPVMh|ryP MXHTRW5ITVJ?
A4-Fuk NVfISVFzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrZNZNKSzVyPUCuNFIzOThizszN NELwO4pUSU6JRWK=
A388 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PnbWlEPTB;MD6wNlIzPyEQvF2= M{H3NnNCVkeHUh?=
TE-9 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHycHdvUUN3ME2wMlAzOjZzIN88US=> M2\nbnNCVkeHUh?=
KURAMOCHI NYDIWnh6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPXUJk4UUN3ME2wMlAzOjh3IN88US=> MoXjV2FPT0WU
KALS-1 NXTO[m1UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGf2bIhKSzVyPUCuNFI{OzhizszN NYLLXpI6W0GQR1XS
HOP-62 NGXCeGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjqTWM2OD1yLkCyOFIh|ryP NV\2Z4J{W0GQR1XS
RPMI-8402 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\yO2lEPTB;MD6wNlUxQCEQvF2= NIjhcFVUSU6JRWK=
TE-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7wTWM2OD1yLkCyOVEzKM7:TR?= MWTTRW5ITVJ?
CCRF-CEM M1PFVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlq4TWM2OD1yLkCyOVQ{KM7:TR?= MlLtV2FPT0WU
HUTU-80 NEi2cJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTLUGM{UUN3ME2wMlAzPjJ2IN88US=> M332bHNCVkeHUh?=
NCI-H1648 NIXCUlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPTTWM2OD1yLkCyOlQ4KM7:TR?= NUnMXlJuW0GQR1XS
HCE-4 NEnkWVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrRTWM2OD1yLkCyOlgzKM7:TR?= NWLtd2ZqW0GQR1XS
ETK-1 Mo\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\y[GlEPTB;MD6wNlc{PiEQvF2= M1HRe3NCVkeHUh?=
TE-15 NWHvb|NJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTBwMEK3N|gh|ryP Mlz1V2FPT0WU
BE-13 M3foU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTBwMEK3OEDPxE1? M3PNd3NCVkeHUh?=
KE-37 NFjZZmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LpU2lEPTB;MD6wNlc1OSEQvF2= MnTZV2FPT0WU
NCI-H1355 NXvLUmZ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwMEK3PFMh|ryP NHPRUo1USU6JRWK=
TE-11 Mnz1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUSwN5NbUUN3ME2wMlAzQDB7IN88US=> M4P5O3NCVkeHUh?=
BL-70 NFvFXVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH70OmVKSzVyPUCuNFI5PTdizszN MmTJV2FPT0WU
ES6 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXKZ3VKSzVyPUCuNFI5QDFizszN NUHxU3Y1W0GQR1XS
GT3TKB M{i1Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTBwMEK5OVMh|ryP NHuxeHlUSU6JRWK=
LB647-SCLC NGXPU2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrMXIJYUUN3ME2wMlA{OTl3IN88US=> M3mwenNCVkeHUh?=
NB13 M1KyTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\5TWM2OD1yLkCzN|E3KM7:TR?= NIG0OFFUSU6JRWK=
ST486 NEjxcIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2Pwd2lEPTB;MD6wN|M{PyEQvF2= MmP3V2FPT0WU
NCI-H82 M3niNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwMEOzOFMh|ryP NH3mPGNUSU6JRWK=
NTERA-S-cl-D1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTBwMEOzPVkh|ryP NWXwVZljW0GQR1XS
ES4 Ml31S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\WTWM2OD1yLkCzOFY{KM7:TR?= NHK2bXRUSU6JRWK=
SK-NEP-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWT2PY1QUUN3ME2wMlA{PDl7IN88US=> NW\Tc2hRW0GQR1XS
Becker MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTBwMEO1OVUh|ryP NHHhVGxUSU6JRWK=
A101D NIXJdWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXHTWM2OD1yLkCzO|Q5KM7:TR?= MVTTRW5ITVJ?
SK-UT-1 NVXEfYJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTBwMEO3O|Qh|ryP MXnTRW5ITVJ?
SW982 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTBwMEO3PUDPxE1? NVHYRnd5W0GQR1XS
TE-10 NFKyTlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTBwMESwOFYh|ryP NXPxOZlVW0GQR1XS
OVCAR-4 M2P3e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvvN2xKSzVyPUCuNFQxPTlizszN MV;TRW5ITVJ?
KP-N-YS MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIj6SpJKSzVyPUCuNFQxQDVizszN NFPQT4VUSU6JRWK=
BL-41 NEXielhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUO3S3VGUUN3ME2wMlA1OTJ3IN88US=> NYfqb5Y6W0GQR1XS
MZ1-PC MlL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwMESxNlch|ryP MnzhV2FPT0WU
PF-382 M4PqUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnLTWM2OD1yLkC0NVk5KM7:TR?= M3T1OHNCVkeHUh?=
MOLT-13 M165VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjHOVNKSzVyPUCuNFQzOzhizszN M1LaVHNCVkeHUh?=
HCC1599 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7ESolPUUN3ME2wMlA1OjV6IN88US=> M3j2b3NCVkeHUh?=
IST-MEL1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfDZnhKSzVyPUCuNFQ1PDJizszN MXLTRW5ITVJ?
LU-139 MnHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTBwMES0OFIh|ryP M2TjXnNCVkeHUh?=
MS-1 M13Gemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXwbXBKSzVyPUCuNFQ4ODFizszN MlLJV2FPT0WU
MFH-ino M3exN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PXUmlEPTB;MD6wOVAxOyEQvF2= NVXPVlVPW0GQR1XS
IMR-5 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\4dGlEPTB;MD6wOVAzOSEQvF2= NVOyS5NjW0GQR1XS
TE-5 NYrZXGF[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrlVGtKSzVyPUCuNFUxPjNizszN MYLTRW5ITVJ?
DJM-1 NGjWclhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHjNGxEUUN3ME2wMlA2OTR{IN88US=> M{jiZXNCVkeHUh?=
NB17 MoHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLHdlBKSzVyPUCuNFUzODdizszN MlTwV2FPT0WU
KARPAS-45 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\P[mlEPTB;MD6wOVM2QCEQvF2= M4PDZ3NCVkeHUh?=
TGBC1TKB NHPU[3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PjcWlEPTB;MD6wOVQxPSEQvF2= MmDiV2FPT0WU
ML-2 MlSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHYN4hRUUN3ME2wMlA2PDF2IN88US=> MlPYV2FPT0WU
no-10 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTNVVQxUUN3ME2wMlA2PDd2IN88US=> MXzTRW5ITVJ?
CTV-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrKd2x4UUN3ME2wMlA2PTB{IN88US=> MoPjV2FPT0WU
SJSA-1 MoThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTBwMEW1NkDPxE1? NI\TWmFUSU6JRWK=
HC-1 NFzUfIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwMEW1PVch|ryP MWXTRW5ITVJ?
TE-12 NHL3bpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jy[mlEPTB;MD6wOVYyOyEQvF2= M4rvTHNCVkeHUh?=
KY821 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PtWGlEPTB;MD6wOVY{OiEQvF2= NIDSfG1USU6JRWK=
TALL-1 M1\jWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjhcXlKSzVyPUCuNFU4ODhizszN NUflN|d3W0GQR1XS
DEL MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwMEW3NFkh|ryP Mk\MV2FPT0WU
TE-6 NETDVGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmq0TWM2OD1yLkC1O|IzKM7:TR?= NVrlb5RDW0GQR1XS
SK-LMS-1 Mn\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzRTWM2OD1yLkC1PFA2KM7:TR?= M3\3cHNCVkeHUh?=
EW-1 M3\3XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHHfpFyUUN3ME2wMlA2QDN5IN88US=> MULTRW5ITVJ?
8-MG-BA MmLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWG1XoFMUUN3ME2wMlA2QDVzIN88US=> MkXkV2FPT0WU
NALM-6 NX\yW4FST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTBwMEW5O|Mh|ryP MkTjV2FPT0WU
LB771-HNC NFz2fYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\YZ2lEPTB;MD6wOVk4QSEQvF2= NEXSc2dUSU6JRWK=
HT-144 NGCxW5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;6bWlEPTB;MD6wOlE{KM7:TR?= M1Lm[nNCVkeHUh?=
KM-H2 NGjKUFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\oXWlEPTB;MD6wOlIzOSEQvF2= NX;6NYhbW0GQR1XS
SF268 NIjXNplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHoTWM2OD1yLkC2Nlg3KM7:TR?= NEnDemlUSU6JRWK=
RS4-11 M{nDTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzPeo9KSzVyPUCuNFY{ODRizszN NVXhc|V6W0GQR1XS
MHH-PREB-1 Ml;oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmW4TWM2OD1yLkC2N|E6KM7:TR?= NVvIOmp2W0GQR1XS
ATN-1 NInuUWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3acnlGUUN3ME2wMlA3OzR3IN88US=> MnTJV2FPT0WU
BB30-HNC MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTBwME[0N|Yh|ryP NFHieHRUSU6JRWK=
CPC-N M4Sye2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HNVWlEPTB;MD6wOlUzPCEQvF2= MVTTRW5ITVJ?
NB1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPYV3ZjUUN3ME2wMlA3PjF|IN88US=> MX;TRW5ITVJ?
KS-1 M3LqbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnuRnlKSzVyPUCuNFY4PDhizszN M1vxSXNCVkeHUh?=
RXF393 NG\tV4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWO2eWZ6UUN3ME2wMlA3PzZ2IN88US=> NFTCfmFUSU6JRWK=
IST-SL2 NVnDWZN[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zMdWlEPTB;MD6wO|AxPCEQvF2= MoTkV2FPT0WU
GI-ME-N MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHzXo5UUUN3ME2wMlA4Ojh4IN88US=> NUHqXWR1W0GQR1XS
VA-ES-BJ NHTyc4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfBTWM2OD1yLkC3OFc2KM7:TR?= NYTOTJRHW0GQR1XS
NCI-H1581 NWT0PYFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnTTWM2OD1yLkC3OFc5KM7:TR?= M2Xw[HNCVkeHUh?=
U-266 MlzlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIW1VmhKSzVyPUCuNFc1QTdizszN M3S0[XNCVkeHUh?=
DMS-114 NGrSc3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rHWmlEPTB;MD6wO|UzQCEQvF2= NWrtco92W0GQR1XS
NCI-H187 NYDkRXVVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVO4Xo1yUUN3ME2wMlA4PzJ4IN88US=> NEP5eo1USU6JRWK=
SW962 NYnjRnR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vzR2lEPTB;MD6wO|g{QSEQvF2= MUPTRW5ITVJ?
MONO-MAC-6 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTL[ZpUUUN3ME2wMlA4QTh4IN88US=> M2nwNnNCVkeHUh?=
MOLT-16 NHzKfVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwMEixNlEh|ryP M1XJeHNCVkeHUh?=
KNS-42 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnDW3VKSzVyPUCuNFgyPjFizszN MXXTRW5ITVJ?
CMK M{ftUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoK4TWM2OD1yLkC4NlI2KM7:TR?= M37lUHNCVkeHUh?=
Ramos-2G6-4C10 MlvwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\rVWdKSzVyPUCuNFgzOjVizszN M3PqdnNCVkeHUh?=
Daudi M3HvN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nVUWlEPTB;MD6wPFI2PiEQvF2= MlraV2FPT0WU
NCI-H510A M3;i[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33DRmlEPTB;MD6wPFM{PiEQvF2= MU\TRW5ITVJ?
LB831-BLC MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LiVWlEPTB;MD6wPFU3OSEQvF2= NH;hNW5USU6JRWK=
HEL MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\NSXRKSzVyPUCuNFg3PjhizszN MVLTRW5ITVJ?
LU-134-A M{PRe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrFPJZxUUN3ME2wMlA5PzB6IN88US=> Mo\ZV2FPT0WU
NCI-H1694 MnK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrETJpKSzVyPUCuNFg4PDRizszN MnTIV2FPT0WU
KGN MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjrTWM2OD1yLkC4O|U6KM7:TR?= NXzaOIREW0GQR1XS
A253 NWn2ZZlGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vLUGlEPTB;MD6wPFgzOiEQvF2= MU\TRW5ITVJ?
DG-75 M{H5WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrlN3VKSzVyPUCuNFg6OjJizszN MVfTRW5ITVJ?
MOLT-4 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTBwMEi5PFMh|ryP NFXOVIhUSU6JRWK=
NCI-SNU-5 Ml;6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwMEmyOVgh|ryP NHrmdXFUSU6JRWK=
ONS-76 NHLBZppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7CdlJrUUN3ME2wMlA6Ojd4IN88US=> NX64e3hsW0GQR1XS
NCI-H446 M{K3U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV[2UWVzUUN3ME2wMlA6PDZ{IN88US=> Mn\TV2FPT0WU
COR-L279 M3;CO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnzfVlKSzVyPUCuNFk2PTZizszN NH35XoZUSU6JRWK=
Calu-6 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYniXYYzUUN3ME2wMlA6PTl6IN88US=> NV[wdYVRW0GQR1XS
BC-3 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{D5WWlEPTB;MD6wPVY3OiEQvF2= MknzV2FPT0WU
NCI-H2126 NFziNVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XQ[GlEPTB;MD6wPVc6OSEQvF2= MULTRW5ITVJ?
NCI-H1882 MlHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjTTWM2OD1yLkC5PFA6KM7:TR?= NFTXWZVUSU6JRWK=
BB65-RCC NYDRSIJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXWz[FlnUUN3ME2wMlExOjl2IN88US=> M2PkTnNCVkeHUh?=
DU-4475 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTBwMUC0NFch|ryP NVLrbZJ4W0GQR1XS
NCI-H526 M4rVcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3vUZJCUUN3ME2wMlExPDRizszN NGi4clZUSU6JRWK=
NEC8 NVTubW9xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jTZmlEPTB;MD6xNFUzPSEQvF2= MofLV2FPT0WU
NCI-H1304 NGfVTYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjjfpJKSzVyPUCuNVA2QTRizszN M4rFc3NCVkeHUh?=
L-540 MlroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTBwMUC3NFgh|ryP NUjse2JMW0GQR1XS
NCI-SNU-16 NYDCWml[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrhcXFKSzVyPUCuNVA4PDJizszN MX\TRW5ITVJ?
HD-MY-Z NYKyVJBoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX76[Y5FUUN3ME2wMlExQDV4IN88US=> NFjWV3NUSU6JRWK=
K-562 M2rJNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTBwMUC4OVgh|ryP NW\lXWp3W0GQR1XS
JAR MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTBwMUC5NlUh|ryP MUfTRW5ITVJ?
MZ2-MEL NWmxO5lkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\yTWM2OD1yLkGxNFUh|ryP MkO5V2FPT0WU
L-363 NGXCTIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;BTlA6UUN3ME2wMlEyODd7IN88US=> NXf6d5VnW0GQR1XS
BV-173 M1n5N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml74TWM2OD1yLkGxNlQ{KM7:TR?= MUXTRW5ITVJ?
NCI-H524 NFr5eI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NED3Z5hKSzVyPUCuNVEzPzRizszN M4nIRXNCVkeHUh?=
EoL-1-cell MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LDV2lEPTB;MD6xNVY4OiEQvF2= NFvUdlJUSU6JRWK=
K052 MmDjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnm1TWM2OD1yLkGxO|EzKM7:TR?= M1\UOnNCVkeHUh?=
TK10 NFz4OmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\i[mlEPTB;MD6xNVczQCEQvF2= NVzVc4s1W0GQR1XS
KU812 NXTNXoF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HDSmlEPTB;MD6xNlA1PCEQvF2= M4r2U3NCVkeHUh?=
RPMI-8226 NXTOSppqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFK4bGlKSzVyPUCuNVIxPTJizszN M2HLUnNCVkeHUh?=
MZ7-mel M4nXb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjqfYtKSzVyPUCuNVIzOzdizszN MVrTRW5ITVJ?
SK-PN-DW NYTtVldmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFH0TFBKSzVyPUCuNVIzQDdizszN NYPxeZc6W0GQR1XS
SR MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorGTWM2OD1yLkGyOFQyKM7:TR?= M4nUOHNCVkeHUh?=
RPMI-6666 MlvXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTBwMUK3OFMh|ryP NIjzO5BUSU6JRWK=
no-11 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTBwMUK4Olkh|ryP NF2zeI1USU6JRWK=
EW-3 MoTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDWTWM2OD1yLkGyPFk{KM7:TR?= NFWz[3FUSU6JRWK=
LAMA-84 NVj4WZYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DodmlEPTB;MD6xN|E5PyEQvF2= NVXlPJU5W0GQR1XS
HT NUnGN4dTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;PcXZKSzVyPUCuNVM2PzRizszN MYHTRW5ITVJ?
KP-N-RT-BM-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTBwMUO2NVIh|ryP MonGV2FPT0WU
NCI-H747 MmjKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTBwMUO3JO69VQ>? MnLpV2FPT0WU
NCCIT MnzmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4C2VWlEPTB;MD6xN|k{QSEQvF2= MX;TRW5ITVJ?
MLMA NGrIdmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTBwMUSxOlch|ryP NYL3UGlNW0GQR1XS
LP-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXudVFKSzVyPUCuNVQzPCEQvF2= NWTzdVFXW0GQR1XS
CAL-148 NIrjUFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfHTWM2OD1yLkG0OFg{KM7:TR?= NXvvWGpIW0GQR1XS
GB-1 NUDJVop5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnUTWM2OD1yLkG0OVI3KM7:TR?= NFHU[YtUSU6JRWK=
COR-L88 MkfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfXTWM2OD1yLkG0PFAzKM7:TR?= Mli0V2FPT0WU
NKM-1 Mn6xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1e5cGlEPTB;MD6xOFkxPiEQvF2= MkXMV2FPT0WU
NB5 NH72fo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWf1U2pyUUN3ME2wMlE2PDZ{IN88US=> MY\TRW5ITVJ?
SH-4 NGnYUlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\6XmFKSzVyPUCuNVU1PjZizszN NFrCPJpUSU6JRWK=
EM-2 NHj0SZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvVTWM2OD1yLkG1OFY4KM7:TR?= M3y2VnNCVkeHUh?=
TGBC24TKB NY[4THdxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnYOpFKSzVyPUCuNVU3PTlizszN M1viTnNCVkeHUh?=
SCLC-21H NVjDVm5rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LV[2lEPTB;MD6xOVcxOiEQvF2= MX\TRW5ITVJ?
COLO-684 NIHNfJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfxdVBKSzVyPUCuNVU4OjFizszN MV;TRW5ITVJ?
KINGS-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHXb5huUUN3ME2wMlE2QTFizszN MVzTRW5ITVJ?
LS-123 M373dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITwOJVKSzVyPUCuNVU6OTdizszN NUO3TmRMW0GQR1XS
MC116 NF7qZoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\GbGlEPTB;MD6xOlE2QCEQvF2= MkDWV2FPT0WU
SU-DHL-1 NF;XUHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoSzTWM2OD1yLkG2NlA3KM7:TR?= M1PLTXNCVkeHUh?=
NCI-H64 M4W2Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTBwMU[zOFch|ryP MWLTRW5ITVJ?
HCE-T M2PUUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DLc2lEPTB;MD6xOlUxPCEQvF2= MV;TRW5ITVJ?
LOXIMVI NF\GNXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfFOoFKSzVyPUCuNVY6PDlizszN M2Wxb3NCVkeHUh?=
ARH-77 M33CSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHhdXJKSzVyPUCuNVc{PzlizszN MYXTRW5ITVJ?
DOHH-2 NH7I[I9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XuV2lEPTB;MD6xO|Y4OiEQvF2= NV30e3NRW0GQR1XS
COLO-320-HSR NX3hWI1jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXxTWM2OD1yLkG4NVU1KM7:TR?= NHf5O4lUSU6JRWK=
NB6 M1jT[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;je45KSzVyPUCuNVg2PjZizszN M1vHVXNCVkeHUh?=
L-428 MkXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH2xbYhKSzVyPUCuNVg5OTNizszN M2i3dXNCVkeHUh?=
SNB75 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7KN4NKSzVyPUCuNVg5OjRizszN NVPoZ4JxW0GQR1XS
NCI-H2141 M3;mdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTBwMUmwNVEh|ryP MmnHV2FPT0WU
KARPAS-299 NH7V[lBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1qx[mlEPTB;MD6xPVI1OSEQvF2= MlfLV2FPT0WU
LC4-1 NFrWeohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwMUm1NFIh|ryP MkmyV2FPT0WU
UACC-257 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF:2XZZKSzVyPUCuNVk6PDdizszN M2HG[HNCVkeHUh?=
EVSA-T MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXiTWM2OD1yLkKwN|EzKM7:TR?= NELwUW9USU6JRWK=
JiyoyeP-2003 M1u2bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHmXXFMUUN3ME2wMlIxPDd5IN88US=> MUfTRW5ITVJ?
NCI-H720 M1ewOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\JcFFKSzVyPUCuNlA2OjVizszN NFy1Z4pUSU6JRWK=
GAK NFnKN3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwMkGxPFkh|ryP NVnoOpFCW0GQR1XS
HH NF;zT|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLkVodCUUN3ME2wMlIyPDB3IN88US=> MVPTRW5ITVJ?
NCI-H1436 NWHlR5BuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUWyd2w3UUN3ME2wMlIyPDZ2IN88US=> MUDTRW5ITVJ?
GR-ST NYXNU2tXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrHS|NYUUN3ME2wMlIyPDh6IN88US=> MVjTRW5ITVJ?
BC-1 NWSyfmNQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTSWINKSzVyPUCuNlI3OTZizszN M12yUHNCVkeHUh?=
SIG-M5 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFr6bodKSzVyPUCuNlI4OjdizszN NEThfllUSU6JRWK=
NCI-H345 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLId3NKSzVyPUCuNlM5ODVizszN Ml24V2FPT0WU
OPM-2 M{GxZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\rU|hKSzVyPUCuNlM5QDJizszN MUnTRW5ITVJ?
LB1047-RCC NXnne|VZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTBwMkS0NUDPxE1? MlLMV2FPT0WU
CTB-1 M{f1NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPTTWM2OD1yLkK0OFk{KM7:TR?= MYjTRW5ITVJ?
A3-KAW MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHz2VZBKSzVyPUCuNlU{PDFizszN MVfTRW5ITVJ?
SF126 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rtVGlEPTB;MD6yOVM5OyEQvF2= Mkm1V2FPT0WU
KARPAS-422 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{X1ZWlEPTB;MD6yOVQ{PSEQvF2= NHzCXJBUSU6JRWK=
MEG-01 MoTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLQXoZKSzVyPUCuNlU3PzNizszN NV;4O49KW0GQR1XS
NCI-H209 MlvYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoT3TWM2OD1yLkK2N|c1KM7:TR?= NX3icJZtW0GQR1XS
SBC-1 NWDld4x7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HOU2lEPTB;MD6yOlUh|ryP MU\TRW5ITVJ?
K5 M4XENGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTBwMk[5PFQh|ryP M{nvTnNCVkeHUh?=
QIMR-WIL NEHpcHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nLXmlEPTB;MD6yO|E2PSEQvF2= NGizO|VUSU6JRWK=
NMC-G1 MmT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwMkiyNVch|ryP MWHTRW5ITVJ?
IST-MES1 MoLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzSTWM2OD1yLkK5NlM5KM7:TR?= Ml7aV2FPT0WU
SW684 M3;0emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrRU5FKSzVyPUCuN|AxPDdizszN MXjTRW5ITVJ?
MV-4-11 Ml64S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmCzTWM2OD1yLkOwO|g5KM7:TR?= NIjXVXJUSU6JRWK=
LAN-6 NXjHSGVIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUL4NHllUUN3ME2wMlMyPTd{IN88US=> NYLGUppEW0GQR1XS
RH-1 MlHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTBwM{G4O|Eh|ryP Mnf4V2FPT0WU
CP66-MEL NELNbIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jtVGlEPTB;MD6zNVg4QCEQvF2= MWDTRW5ITVJ?
EC-GI-10 NGjrSHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwM{K5PFch|ryP NEC3b3JUSU6JRWK=
GDM-1 NE\5bHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH:wcY9KSzVyPUCuN|MxPTlizszN MnfiV2FPT0WU
IST-SL1 NHrEW2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3FfpRKSzVyPUCuN|Q6OTRizszN MlvnV2FPT0WU
KMOE-2 Mn;ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{n2dGlEPTB;MD6zOVE4PSEQvF2= NIfPN4hUSU6JRWK=
OS-RC-2 Mn\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTBwM{W1OFQh|ryP NF71UGZUSU6JRWK=
HDLM-2 NGOyWnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPNcm1KSzVyPUCuN|c5OTRizszN NU\USVZtW0GQR1XS
DSH1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTBwM{i2N|Eh|ryP NGXOcHdUSU6JRWK=
LS-1034 NXnINIJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLwTWM2OD1yLkO4PVU1KM7:TR?= MYDTRW5ITVJ?
LB373-MEL-D NEW4XodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTBwM{mxPVch|ryP NETPRmJUSU6JRWK=
GOTO MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;mZ2lEPTB;MD60NlEyQCEQvF2= NYnPdnc4W0GQR1XS
MRK-nu-1 Ml7xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTBS2FGUUN3ME2wMlQzOjB3IN88US=> NHG5V|RUSU6JRWK=
SK-MM-2 M1ywWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzjTWM2OD1yLkSzOFQzKM7:TR?= MUTTRW5ITVJ?
BOKU NHTqXIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXDU3pKSzVyPUCuOFM4QTJizszN NYj6fWZuW0GQR1XS
NOMO-1 NF3uZ|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfr[okyUUN3ME2wMlQ{QDZizszN M{OyTXNCVkeHUh?=
J-RT3-T3-5 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTBwNES4O|gh|ryP M2qxSnNCVkeHUh?=
COLO-668 MoXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwNEW2Olgh|ryP MonKV2FPT0WU
SF539 MnWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzhPWpKSzVyPUCuOFg3QDRizszN NHnvXVJUSU6JRWK=
LB2518-MEL NGDOWZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXlbYxKSzVyPUCuOFk4ODNizszN MUfTRW5ITVJ?
TE-441-T MmnXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\sTINrUUN3ME2wMlUxOTJizszN MX3TRW5ITVJ?
MDA-MB-134-VI MlPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjpXmRVUUN3ME2wMlUxQTJzIN88US=> NWrDO4h4W0GQR1XS
SCC-3 M2DXWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTBVHlMUUN3ME2wMlUyQDd|IN88US=> MnjOV2FPT0WU
KLE NEfocWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTBwNUKxO|Eh|ryP MnjTV2FPT0WU
LB2241-RCC M1f0fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjDcGNKSzVyPUCuOVI2OjVizszN MlnEV2FPT0WU
NCI-H1417 NETnZVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LDbmlEPTB;MD61N|Q{PSEQvF2= MmO4V2FPT0WU
NCI-H2081 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfPPFdKSzVyPUCuOVg3OTFizszN MkXyV2FPT0WU
NCI-H1522 MmXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrLc4xKSzVyPUCuOVk{QDNizszN M4DVbnNCVkeHUh?=
NCI-H889 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFGx[HBKSzVyPUCuOVk5PDRizszN Ml\wV2FPT0WU
CGTH-W-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\kfWlEPTB;MD62NFc2PSEQvF2= MVXTRW5ITVJ?
EB-3 Mlf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvkT29mUUN3ME2wMlYyOTV|IN88US=> M17WbXNCVkeHUh?=
D-336MG NVPN[oliT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nufGlEPTB;MD62NVc6OSEQvF2= M3z1WXNCVkeHUh?=
LC-1F NETwNJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYGxUII1UUN3ME2wMlYzPTl{IN88US=> MoTSV2FPT0WU
MHH-NB-11 M17tVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwNkO4NFEh|ryP NF3vUI9USU6JRWK=
SK-N-FI NULIZphST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1u0eWlEPTB;MD62N|kyKM7:TR?= MV3TRW5ITVJ?
NCI-H69 M{nlR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;ETWM2OD1yLk[0PFc6KM7:TR?= Ml6zV2FPT0WU
SCH M1rCW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwNk[wNlMh|ryP NFXiSnNUSU6JRWK=
LS-513 NVmweHdXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwNkeyOVkh|ryP M2fvTHNCVkeHUh?=
CP67-MEL NX7jXJBpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTBwNke1PVYh|ryP NULUeXZYW0GQR1XS
GCIY NEnuPZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmSxTWM2OD1yLkewN|Y{KM7:TR?= MYLTRW5ITVJ?
SHP-77 NX3iVJI3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwN{C3N|Qh|ryP MlG3V2FPT0WU
EHEB M3PzVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTBwN{G4OVQh|ryP MkflV2FPT0WU
D-247MG NXnkTVljT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnW3TWM2OD1yLkezNlMzKM7:TR?= NIG3UZVUSU6JRWK=
Raji NUDn[VFDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrINJpKSzVyPUCuO|Q6QDlizszN MYXTRW5ITVJ?
MPP-89 Mm\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHCTotPUUN3ME2wMlc2QTd6IN88US=> MVXTRW5ITVJ?
EKVX NW\TXJhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwN{mwO|Mh|ryP MV\TRW5ITVJ?
HCC2218 NFjWUmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3GwdWlEPTB;MD63PVE{OSEQvF2= NXf2ZXVZW0GQR1XS
KNS-81-FD MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwOEGwNVEh|ryP MWrTRW5ITVJ?
HCC2157 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkWxTWM2OD1yLki0PVUyKM7:TR?= MVvTRW5ITVJ?
BT-474 NFfVd|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3mVmNKSzVyPUCuPFg5PTRizszN M3P3[3NCVkeHUh?=
NCI-H748 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvEblA1UUN3ME2wMlkyOiEQvF2= NVToNmx3W0GQR1XS
EW-24 Mm\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPhRoN[UUN3ME2wMlkzODB{IN88US=> NGnzXYVUSU6JRWK=
D-263MG M1fkV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLKcndKSzVyPUCuPVQ2OTJizszN MonzV2FPT0WU
OMC-1 NUn6d45ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPhUnFKSzVyPUCuPVY{PzNizszN M3PLS3NCVkeHUh?=
NCI-H2196 M2CzfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTBwOUe3O|ch|ryP MkLCV2FPT0WU
HAL-01 M3z3bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjXTWM2OD1yLkm5PFczKM7:TR?= M3zqNnNCVkeHUh?=
NCI-H2107 NW\JXVJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HIOWlEPTB;MT6wNVg2PCEQvF2= M1jD[XNCVkeHUh?=
LB996-RCC Mn[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTFwMEiwOVEh|ryP NH;OdVdUSU6JRWK=
NCI-H1395 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLZSXFzUUN3ME2xMlExPjdizszN MoXkV2FPT0WU
CHP-126 NFHHeJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moe5TWM2OD1zLkG2NVk6KM7:TR?= MX\TRW5ITVJ?
NB69 M{HrSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX[1SpdJUUN3ME2xMlI3OTR6IN88US=> MnzUV2FPT0WU
CAS-1 NHHzR2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3QTWM2OD1zLkO0NlMyKM7:TR?= MoPxV2FPT0WU
JVM-3 NIPR[FdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTFwNEe4OVUh|ryP MYjTRW5ITVJ?
DMS-153 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVH6b5ByUUN3ME2xMlU4Pjd2IN88US=> MYHTRW5ITVJ?
SK-MEL-2 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWT0ZYx2UUN3ME2xMlcyPzh7IN88US=> NI\HUplUSU6JRWK=
NCI-H1155 NEL0bYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTFwN{O2O|Yh|ryP NGLMR4RUSU6JRWK=
NCI-H1092 M2TsWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTFwN{[xPFIh|ryP M1naSXNCVkeHUh?=
LU-165 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEGwXIJKSzVyPUGuPFY1PzZizszN M4fXTnNCVkeHUh?=
HL-60 NWe5cpZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnZfYJKSzVyPUGuPVk6ODhizszN M4S2THNCVkeHUh?=
REH NUTiW3hPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTJwMEC1PFIh|ryP Mn73V2FPT0WU
JVM-2 MnKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDBTWM2OD1{LkC2NVM2KM7:TR?= NF7xXFdUSU6JRWK=
MN-60 MonLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTJwMUezNFgh|ryP NG[w[4lUSU6JRWK=
SCC-15 NX;FVmE3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTpTWM2OD1{LkKwNlch|ryP M1rUOXNCVkeHUh?=
SNU-C1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nCdmlEPTB;Mj6yNVM1OyEQvF2= MnHkV2FPT0WU
SK-MEL-1 NFv0bmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVv4UJFMUUN3ME2yMlMzODR5IN88US=> M1PzO3NCVkeHUh?=
TGW NH36UotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTJwM{WwNlch|ryP NGTEW2NUSU6JRWK=
CA46 M{D3ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DpdGlEPTB;Mj63OVk3PyEQvF2= MXPTRW5ITVJ?
NCI-H23 NEj4Z|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULtWZRrUUN3ME2yMlgxPzlzIN88US=> NV3V[phjW0GQR1XS
MMAC-SF NF3oXI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmr4TWM2OD1{Lki2OlI5KM7:TR?= NYmyT2FsW0GQR1XS
NCI-H2171 NX\aWG5pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfQT5JKSzVyPUOuNFM1PDhizszN MmjpV2FPT0WU
A704 NUD3NVZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nyUmlEPTB;Mz6xOFE6PCEQvF2= NYj3PIhnW0GQR1XS
DB Ml\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jQZ2lEPTB;Mz6yOVU4PiEQvF2= MofQV2FPT0WU
NCI-H719 M{HyeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{[5T2lEPTB;Mz6zNFM5PCEQvF2= NWqweZZUW0GQR1XS
MC-CAR MontS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF:4XWpKSzVyPUOuOVQ5OTdizszN Mn[4V2FPT0WU
SIMA NF\OTXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPUdJNFUUN3ME2zMlU5PDF4IN88US=> NVjOV2JsW0GQR1XS
SW872 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HNVmlEPTB;Mz63PFExOSEQvF2= NIO0[25USU6JRWK=
HCC1187 NWHSc5lNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTNwN{izNVUh|ryP MlnFV2FPT0WU
EW-13 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnEUlJwUUN3ME2zMlg{PDF5IN88US=> NG\yTIFUSU6JRWK=
NCI-SNU-1 NV3kcZB1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfoTWM2OD12LkKxPVk6KM7:TR?= M3r4VnNCVkeHUh?=
NCI-H226 NIXlVIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGWzRolKSzVyPUSuN|M3ODZizszN NEfoV5JUSU6JRWK=
RPMI-8866 M361fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DpWmlEPTB;ND6zOlAzQSEQvF2= NUTkdFRMW0GQR1XS
OCI-AML2 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1L5WGlEPTB;ND61OVI{KM7:TR?= NV:3ZYp4W0GQR1XS
LU-65 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHGTWM2OD12LkmzNFM{KM7:TR?= NIryS2VUSU6JRWK=
SK-N-DZ Ml\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTVwNkO0OlUh|ryP NXi4SmgyW0GQR1XS
NB14 NV;6Z3dlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTVwOUexN|Uh|ryP MoKwV2FPT0WU
COLO-829 M4T4Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDp[4R7UUN3ME22MlM{OzV7IN88US=> NUHN[5M6W0GQR1XS
MHH-CALL-2 M1HIVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;CPW1KSzVyPU[uOVE2ODhizszN MV7TRW5ITVJ?
NCI-H1770 M{XpOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjqTWM2OD14Lk[2PVA1KM7:TR?= NV7Wb2JnW0GQR1XS
ECC4 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTCWoZKSzVyPU[uPFIyPzlizszN NVvOO|FXW0GQR1XS
A498 NFvWVpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTZwOEexPVIh|ryP Mn3vV2FPT0WU
DMS-79 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M171S2lEPTB;Nz6wOFUyOiEQvF2= NFW0VZRUSU6JRWK=
P30-OHK NX3xd5htT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITwV|dKSzVyPUeuNlE6ODZizszN NYHKZ20{W0GQR1XS
D-502MG NXnUWY9GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTdwOUizOkDPxE1? NFXteI5USU6JRWK=
RCC10RGB NUPURm1NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRThwME[yPEDPxE1? MXfTRW5ITVJ?
U-698-M NUm4UFhZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPIcGxKSzVyPUiuNlkzOjZizszN NFXLfVZUSU6JRWK=
BB49-HNC NX7QN3FiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXKzflFlUUN3ME25MlQzOjZ3IN88US=> M3HXXHNCVkeHUh?=
ES1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLKTWM2OD17Lk[4PVU3KM7:TR?= NIS3bplUSU6JRWK=
MFM-223 M3fRdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELHSFBKSzVyPUGwMlk6OjdizszN M3u4WHNCVkeHUh?=
C2BBe1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTjc2dPUUN3ME2xNU4{PTJ|IN88US=> MkXQV2FPT0WU
EB2 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XwO2lEPTB;MUKuOlg5OSEQvF2= MmW4V2FPT0WU
C8166 MkLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnxTWM2OD1zMz64N|A{KM7:TR?= M2G4[nNCVkeHUh?=
ES3 MmftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrOO49KSzVyPUGzMlk6PzdizszN MlvMV2FPT0WU
NCI-H1650 M13SZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPtOGxKSzVyPUG2MlM4PjVizszN NUHr[lRrW0GQR1XS
Mo-T NHLrN5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFj6TndKSzVyPUG3MlQxOjlizszN Mom1V2FPT0WU
NB7 M3m4Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4[0WWlEPTB;MUeuO|Q3PyEQvF2= NYXaUFF7W0GQR1XS
ES7 MlnHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;TSmlEPTB;MUmuOVUxPyEQvF2= MX3TRW5ITVJ?
ES5 M2rXXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\wTWM2OD1{MT63OlcyKM7:TR?= M3XJR3NCVkeHUh?=
MSTO-211H Mon4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XGVWlEPTB;MkGuPFg2QCEQvF2= NEDJ[IZUSU6JRWK=
U-87-MG NIrYRYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jCSGlEPTB;MkWuNVk3PiEQvF2= MVzTRW5ITVJ?
THP-1 M3jhWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;5TWM2OD1{OT63NlAyKM7:TR?= NX3wcnlSW0GQR1XS
NB10 M2[2XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjLUJM3UUN3ME2zNE4zPjl2IN88US=> NIDVdnJUSU6JRWK=
NH-12 NET0PZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LGZmlEPTB;M{OuNlAyPyEQvF2= MYfTRW5ITVJ?
COLO-824 M3rOOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;3SGVXUUN3ME2zOE4yODB4IN88US=> Mn;qV2FPT0WU
SKM-1 M1rYSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\qcnU5UUN3ME2zO{45PDJ{IN88US=> NYCxfIFmW0GQR1XS
NCI-H1838 NGDtbXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzmTWM2OD1|OD6zO|k4KM7:TR?= M2rBNnNCVkeHUh?=
RL NXTsXIdxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTN7LkK0O|ch|ryP MUHTRW5ITVJ?
COLO-800 Mnu3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnIXINwUUN3ME20NE4xPzd|IN88US=> M2i3cnNCVkeHUh?=
KG-1 M{TkNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\DeWlEPTB;NECuPFk2PSEQvF2= M2fC[XNCVkeHUh?=
TUR NYXvdWh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTRzLk[zPVkh|ryP NH\IO21USU6JRWK=
LNCaP-Clone-FGC MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PVb2lEPTB;NEGuPVAyPyEQvF2= NVHhNW5MW0GQR1XS
NCI-H322M M4PBd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn6wTWM2OD12Mj61PVg1KM7:TR?= MV;TRW5ITVJ?
LNCaP  M1X5[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDkT5A1UUN3ME25NU4{KG6P NFK5PZUzPTVyNUG3OC=>
C4-2 MoPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRThibl2= MojqNlU2ODVzN{S=
JURKAT NU\3TYdJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fRelI1KGh? Mk\iTWM2OD12MU[uOlYhdk1? MXSyOFUyQTl7NR?=
MOLT-4 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk[xNlQhcA>? MWnJR|UxRTJ6NUOuOUBvVQ>? NHfwd3ozPDVzOUm5OS=>
REH M13IeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPN[HAzPCCq NHv6UmdKSzVyPUK4O{43QCCwTR?= Ml;NNlQ2OTl7OUW=
NALM-6 NF3rdmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIL5ZWIzPCCq MmSyTWM2OD1|NEOzNEBvVQ>? M1TKWlI1PTF7OUm1
RS 4;11 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XSflI1KGh? MnrVTWM2OD13MUmuNFUhdk1? NELMb2kzPDVzOUm5OS=>
697 MoLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLINlQhcA>? M1\3VWlEPTB;MkGwO{4yKG6P MXWyOFUyQTl7NR?=
SIL-ALL M1zvUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHT6O5EzPCCq Mm\wTWM2OD1zOUmuO|chdk1? NHXoeXIzPDVzOUm5OS=>
CEM NGmy[HJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUSyOEBp NIfVc4RKSzVyPUWyMlE5KG6P NVr5OVZ[OjR3MUm5PVU>
P12 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV6yOEBp NYjxS4l[UUN3ME2zPU4zPyCwTR?= M2XCcFI1PTF7OUm1
NALM-16 NHLzRpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\zU5gzPCCq MXvJR|UxRTl4LkK4JI5O NVnIOWF5OjR3MUm5PVU>
JURKAT MnvRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrQ[WNbPDhiaB?= NYC2fHJbUUN3ME2xOE45PCCwTR?= MW[yOFUyQTl7NR?=
MOLT-4 NGjvSYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPJOFghcA>? NFrKdndKSzVyPUK2MlYhdk1? MV:yOFUyQTl7NR?=
REH NXTS[2NbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\OOFghcA>? NYrpXYprUUN3ME20OE44OSCwTR?= MnLvNlQ2OTl7OUW=
NALM-6 NVnQ[npOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVi0PEBp MYLJR|UxRTJ|LkK2JI5O M{PNXVI1PTF7OUm1
RS 4;11 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVS0PEBp NEPvXGxKSzVyPUG2OE4zQCCwTR?= M1;IVlI1PTF7OUm1
697 MnjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjwOFghcA>? NF7E[HdKSzVyPUOwOU4{KG6P NF;sc20zPDVzOUm5OS=>
SIL-ALL MmjTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvDOFghcA>? M1;1Z2lEPTB;N{SuOlIhdk1? NGXhbZczPDVzOUm5OS=>
CEM MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DKU|Q5KGh? Mo\6TWM2OD1{ND61OUBvVQ>? M1nzPVI1PTF7OUm1
P12 M2fkZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmm4OFghcA>? NF3UTJpKSzVyPUG4MlQ3KG6P NGjCc5czPDVzOUm5OS=>
NALM-16 MlHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3r1NFQ5KGh? MlnITWM2OD14Mz6yOEBvVQ>? NH;5R5EzPDVzOUm5OS=>
JURKAT NGfIOIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnH0O|IhcA>? M3jhT2lEPTB;Mz62OUBvVQ>? MoTnNlQ2OTl7OUW=
MOLT-4 NWDzOlNCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPQO|IhcA>? NHvLS3ZKSzVyPUeuN|khdk1? NILPV40zPDVzOUm5OS=>
REH MkPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWW3NkBp MYfJR|UxRTF4LkCxJI5O NIHEOJgzPDVzOUm5OS=>
NALM-6 NWTNN|hbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTDO|IhcA>? NXvtZohXUUN3ME2xMlc5KG6P M2XOdFI1PTF7OUm1
RS 4;11 Mm\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nlZVczKGh? NXPsbld[UUN3ME20MlM5KG6P MknSNlQ2OTl7OUW=
697 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XoTFczKGh? Mn[0TWM2OD15ND6yPEBvVQ>? Mnf1NlQ2OTl7OUW=
SIL-ALL M3S3cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfBO|IhcA>? NX\odFR1UUN3ME23MlIhdk1? NHHQT4QzPDVzOUm5OS=>
CEM NEHrc4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;vV|czKGh? NWDGfnd6UUN3ME21MlQzKG6P Mn2xNlQ2OTl7OUW=
P12 M4fH[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{i3UFczKGh? NV;3epNNUUN3ME22MlM4KG6P MmryNlQ2OTl7OUW=
NALM-16 M4L2bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTYZYMyPzJiaB?= MYfJR|UxRTd5LkezJI5O M1rVXlI1PTF7OUm1
Y79 Mn63RZBweHSxc3nzJGF{e2G7 Mn;TNU02OCCwTR?= M4jmdlEzNzJ2IHi= Ml\FSG1UVw>? NHvycZlqdmS3Y3XkJIFxd3C2b4Ppd{B4cGmlaDDjZY4h[mViZX7oZY5k\WRiYomgTHQ> NFjMZmQzPDN4Nk[2OS=>
WER-Rb-1 MXvBdI9xfG:|aYOgRZN{[Xl? NUT4cHdXOS13MDDuUS=> NXXCNXB3OTJxMkSgbC=> NHuxcpBFVVOR NGDIRYNqdmS3Y3XkJIFxd3C2b4Ppd{B4cGmlaDDjZY4h[mViZX7oZY5k\WRiYomgTHQ> NHrOVlczPDN4Nk[2OS=>
G7 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTNwMzDuUS=> NVTZdZptOjR{MES3N|M>
G166 NIO4PZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTVTWM2OD15LkCgcm0> M1fsV|I1OjB2N{Oz
CB660 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYP6eVNTUUN3ME22MlQhdk1? NXS4TFllOjR{MES3N|M>
CB1117 NXS0NVY3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTF3Lk[gcm0> Ml3CNlQzODR5M{O=
KB-3-1 NUDzfI5QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVOwTox{UUN3ME2xMlQ5KMLzIECuOVMhdk1? NV2xT5huOjN7NkK0OFU>
KB-8-5-11 NITCfotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3SyZWlEPTB;NT6wNUDDuSB{LkCxJI5O NFnlOVEzOzl4MkS0OS=>
KB-C-1 NGn0[pJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrBTWM2OD1zNj63OkDDuSB2LkWxJI5O NFi1O5ozOzl4MkS0OS=>
KB-V-1 M3\uc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3DTnVZUUN3ME2yPFEvOjRiwsGgN|EvPTdibl2= M1T6cVI{QTZ{NES1
OVCAR-8 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{H6[WlEPTB;Nz6xPUDDuSB|Lk[wJI5O NVTndIlbOjN7NkK0OFU>
NCI-ADR-RES NIraZYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFftVphKSzVyPUGyO|MvOzBiwsGgNVkyNjJyIH7N MWCyN|k3OjR2NR?=
MCF7 M1;P[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTPVHJEUUN3ME21MlEyKMLzIEGuOFchdk1? M1TJc|I{QTZ{NES1
MCF7-FLV1000 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUG2PYlRUUN3ME2zPVMvOThiwsGgO|QvQDNibl2= M3HOSVI{QTZ{NES1
S1 MnfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTJ2LkOwJOKyKDRwN{Wgcm0> NX;RWnpWOjN7NkK0OFU>
S1-M1-80 M{WyV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PqfWlEPTB;Mk[xMlA3KMLzIES4MlI2KG6P MnvwNlM6PjJ2NEW=
CORL-23/P NWD4Z2U4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFezS|lKSzVyPUSuN|ghyrFiMT6yOUBvVQ>? NX62NlBIOjN7NkK0OFU>
CORL-23/R NXfiZ4hzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULTeXFbUUN3ME21MlE3KMLzIEGuPFMhdk1? M1fIVlI{QTZ{NES1
NIH3T3 MlLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PpZmlEPTB;NECuOlAhyrFiND65O{BvVQ>? NIntZZozOzl4MkS0OS=>
NIH3T3-G185 NWGzTYpvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;5NXhKSzVyPUK0NVMvPDBiwsGgOFI{NjZ4IH7N MUmyN|k3OjR2NR?=
pcDNA-HEK293 NUfRblh5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTKRVdKSzVyPUKuO|UhyrFiMD62O{BvVQ>? MnzWNlM6PjJ2NEW=
MDR19-HEK293 M4jtTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTh3LkWwJOKyKDF|Lk[3JI5O NYXrS4x[OjN7NkK0OFU>
R482-HEK293 MmjzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLEOoYyUUN3ME2yOU46PyEEsTC0Mlk2KG6P NVXrXXRMOjN7NkK0OFU>
MRP1-HEK293 NXjkS49VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXoTWM2OD1{Lkm5JOKyKDFwNEmgcm0> NFPyW|YzOzl4MkS0OS=>
SF188 M1rzSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnS1NVAuOTByIH7N MnjRNlQuQTZiaB?= M37PfGROW09? MX\pcohq[mm2czDj[YxtKGe{b4f0bEBqdiCkb4ToJJRqdWVvIHHu[EBkd26lZX70doF1cW:wLTDk[ZBm\GWwdDDtZY5v\XJ? NFLVWJUzOzh6N{[0OS=>
T98G MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHnOVhlOTBvMUCwJI5O NULL[msxOjRvOU[gbC=> NIq0bFFFVVOR NFLKS49qdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDjc45k\W62cnH0bY9vNSCmZYDl[IVvfCCvYX7u[ZI> M2D6WFI{QDh5NkS1
DU145 M13lVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTYb4RwTE2VTx?= MWfJR|Ux6oj:NkCgcm0> NYnqW4doOjN6OES0Nlg>
LNCaP  NX\VNYVqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nHbWROW09? NX:4fJNYUUN3MPMIwFc2KG6P NFLYPGozOzh6NESyPC=>
PC3 MofBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkK1SG1UVw>? Mo\vTWM2OOLKvEG3OUBvVQ>? M2H4Z|I{QDh2NEK4
RT4 M3v5NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mom0TWM2OD1{Nz6yNUBvVQ>? MU[yN|c6OjZ|OR?=
5637 NUfMfXdxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDJOJNKSzVyPUS1MlQ4KG6P MXqyN|c6OjZ|OR?=
T24 M3\WWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjLTWM2OD15OT6xNkBvVQ>? M4jVTFI{Pzl{NkO5
MCF7  M3\SXWZ2dmO2aX;uJGF{e2G7 MnTTNVAxKG6P M1zJblEhcA>? NUfPT253TE2VTx?= MXvy[YR2[2W|IITo[UBqdmS3Y4Tpc44hd2cEoFfy[YIyNMLiU3frNUzDqFC|Mj|CpHNmenCrbnGzMEBidmUEoGfpd5Az MoLFNlM4PzB{NES=
KB-V1  MkDlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIqxNJpKSzVyPUOuPVIh|ryP MXKyN|U6OzF7Nh?=
Hec50co NF;iTHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rseGlEPTB;NTDuUS=> M3rrcVI{OTR4Nki3
MDA-MB-468 M33EfGFxd3C2b4Ppd{BCe3OjeR?= NF[zcnQyNzVxMUCgcm0> NX7ZUHZQOjRxNEivO|IhcA>? MVTEUXNQ MV3pcoR2[2W|IHHwc5B1d3OrczDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= NF3zcHYzOzF2NEK5OC=>
MCF10A NVXtW251SXCxcITvd4l{KEG|c3H5 M17Jd|EwPS9zMDDuUS=> M4PoZ|I1NzR6L{eyJIg> M3mwdGROW09? MkPpbY5lfWOnczDhdI9xfG:|aYOgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= Mlr3NlMyPDR{OUS=
Huh-7 NE\ySYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvEUXlNOS9zMD:xNFAwOTByMDDuUS=> MorpOFghcA>? NF;1[5Fl\WO{ZXHz[ZMhfGinIHPlcIwhfmmjYnnsbZR6KGSxc3Wt[IVx\W6mZX70cJk> NVXnS|RQOjJ5NEW1PFc>
Daoy  MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETEW40yNjh5NT2yOFAhdk1? NFHuPXU4OiCq NW\6WIxmTE2VTx?= MWPJR|UxRTVibl2= M{\JOFIzOzlyMke5
ONS-76 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV[xMlg4PS1{NECgcm0> NVXnbY9sPzJiaB?= NU\KZYh3TE2VTx?= MojSTWM2OD15LkWgcm0> NV\4cll6OjJ|OUCyO|k>
SUM 149 MmTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrXNFcxNTFyMDDuUS=> NFXEcW84OiCq M1TJd4lvcGmkaYTzJJRp\SClZXzsJJZq[WKrbHn0fUBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7hdi=> M1;2dlIzOzB7OUO5
MDA-MB-231 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPONE0yODBibl2= MmC5O|IhcA>? MWLpcohq[mm2czD0bIUh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wYYK= NYDQdIF3OjJ|MEm5N|k>
HR5 NXOwW4JGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLrNXo6OC1zMECgcm0> M2DWXFczKGh? MX;pcohq[mm2czD0bIUh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wYYK= M2XxNFIzOzB7OUO5
BT-474-M1 M{\2dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVmwMVExOCCwTR?= NWfEWWlLPzJiaB?= NVmwS2RQcW6qaXLpeJMhfGinIHPlcIwhfmmjYnnsbZR6KGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoFz NUDzUWN3OjJ|MEm5N|k>
AU565 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXi5XZdLOC1zMECgcm0> NV7ke5l1PzJiaB?= M12xNolvcGmkaYTzJJRp\SClZXzsJJZq[WKrbHn0fUBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7hdi=> M12z[FIzOzB7OUO5
T47D NWTUR|JNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnG3NE0yODBibl2= MV23NkBp MXnpcohq[mm2czD0bIUh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wYYK= MVqyNlMxQTl|OR?=
MCF7 M{LTUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXMenNrOC1zMECgcm0> MVy3NkBp M2e2XYlvcGmkaYTzJJRp\SClZXzsJJZq[WKrbHn0fUBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7hdi=> MmPNNlI{ODl7M{m=
HCT116p53(+/+) MoPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HabFExNTFyMECgcm0> M1KwXlI1NzR6IHi= MUfpcohq[mm2czDj[YxtKHC{b3zp[oVz[XSrb36gZ49ueGyndHXsfUBifCB{NTDuUS=> NF\CflAzOjJ4MkG3NS=>
HCT116p53(-/-) NXnGS5NiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWGyeYVzOTBvMUCwNEBvVQ>? MmTiNlQwPDhiaB?= MnL0bY5pcWKrdIOgZ4VtdCCycn;sbYZmemG2aX;uJINwdXCuZYTlcJkh[XRiMkWgcm0> MmXpNlIzPjJzN{G=
HeLa  MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILIPXcyOC1zMECgcm0> MmXVOFghcA>? MVfEUXNQ M{PkbGlEPTB;NUKuPUBvVQ>? Mn3LNlIxQDB{M{W=
HeLa  NGHRe2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXO5PFVyOTBvMUCwJI5O NY\qPXhmPzJiaB?= NXq3XmNqTE2VTx?= NYLnSGViUUN3ME21NE42KG6P NXy2dVlLOjJyOECyN|U>
GBC NUniXlBXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HIdFczKGh? MVzJR|UxRTF2Lke4JI5O MXiyNVk3PTd|OR?=
GB-CL-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\ENoQ4OiCq NX\QNZNtUUN3ME21MlIzKG6P MXeyNVk3PTd|OR?=
Mz-ChA-2 MljZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLjXoY4OiCq Ml;uTWM2OD1|LkOxJI5O MXeyNVk3PTd|OR?=
TGBC1-TKB M3zlW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV2xOFQhcA>? MnziTWM2OD14LkeyJI5O NFrqbZIzOTl4NUezPS=>
Wittier NXXSepRWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;1bFczKGh? M3WzbGlEPTB;Mz6yOkBvVQ>? MlLJNlE6PjV5M{m=
H-1 NIC1VI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXUO|IhcA>? M4fBbmlEPTB;OT61OEBvVQ>? MUOyNVk3PTd|OR?=
HuH-28 NHX0PZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDnXXJlPzJiaB?= MYjJR|UxRTFzLkG5JI5O MUSyNVk3PTd|OR?=
NEC MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjw[GhqPzJiaB?= NEG0N3lKSzVyPUmuPVghdk1? MYSyNVk3PTd|OR?=
REB M4[3e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17mVFczKGh? M1PqVGlEPTB;MUOuOVEhdk1? NV;mfI1DOjF7NkW3N|k>
CC-LP-1 NUe0XWJtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUS3NkBp M37KPGlEPTB;NT64OEBvVQ>? MVGyNVk3PTd|OR?=
CC-SW-1 Mn7FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPaO|IhcA>? M3rENWlEPTB;OT61OUBvVQ>? Mn\SNlE6PjV5M{m=
EGI-1 NXKzWXp7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUC3NkBp M4PtRWlEPTB;MUCuO|Ihdk1? NGL0U|AzOTl4NUezPS=>
Sk-ChA-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrt[YE4OiCq MWDJR|UxRTF5LkKgcm0> NFTlNGMzOTl4NUezPS=>
TFK-1 NYXFNYN7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVK3NkBp NHTteIdKSzVyPUGzMlQ2KG6P MlHqNlE6PjV5M{m=
786-O MnPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1Hib|UuQDBibl2= MWe5OkBp M2D2WGhEdA>? M1XKPZN2eHC{ZYPz[ZMhfGinIIDyc4xq\mW{YYTpc44hcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZIhf2m2aDDJR|UxyqC4YXz1[ZMhd2ZiMjD0c{AzOCCwTR?= NF3SfYozOTZ2MkO3OC=>
A498 MmfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUC1MVgxKG6P MmrBPVYhcA>? NX7KWGg4UEOu NEH4[IJ{fXCycnXzd4V{KHSqZTDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVzKHerdHigTWM2OMLidnHseYV{KG:oIEKgeI8hOjBibl2= M3rpUVIyPjR{M{e0
ACHN Mlm1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXG1MVgxKG6P MnjhPVYhcA>? NYjvU|NXUEOu NXjzc|BHe3WycILld5NmeyC2aHWgdJJwdGmoZYLheIlwdiCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meiC5aYToJGlEPTEEoI\hcJVmeyCxZjCyJJRwKDJyIH7N MkC2NlE3PDJ|N{S=
Caki-1 MnznS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXwTo9qPS16MDDuUS=> M3XvTlk3KGh? NWflUlNiUEOu M4j3SJN2eHC{ZYPz[ZMhfGinIIDyc4xq\mW{YYTpc44hcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZIhf2m2aDDJR|UxyqC4YXz1[ZMhd2ZiMjD0c{AzOCCwTR?= NWDMTXZMOjF4NEKzO|Q>
SN12C MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXXWpc2NThyIH7N NVzBdo9DQTZiaB?= NIf2ToJJS2x? MVXzeZBxemW|c3XzJJRp\SCycn;sbYZmemG2aX;uJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXyJJdqfGhiSVO1NOKhfmGudXXzJI9nKDJidH:gNlAhdk1? NUnDR3hvOjF4NEKzO|Q>
HMC-1.1 M3Tw[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rM[|EuOTByMDDuUS=> NIjyVmQ4OiCq Mle4bY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5m M1PVd|IyOjR{MUi5
HMC-1.2 Mn\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDaNU0yODByIH7N NV\Bb5JpPzJiaB?= NYnyOJZ3cW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6n MmfMNlEzPDJzOEm=
C2 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX2xMVExODBibl2= MXG3NkBp MYPpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoU> MoHxNlEzPDJzOEm=
CHP-212 M1;kT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jQcVEuOTJ3IH7N NVjDXpQ5OjRvMUKwJIg> NHHFOpVqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l MojXNlEyPjl{NEK=
IMR-32 NWH0cm5sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLBNU0yOjVibl2= NWHZ[5NnOjRvMUKwJIg> NIrsW2ZqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l NIDTRZkzOTF4OUK0Ni=>
Kelly MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVn0NVBCOS1zMkWgcm0> NGrBUJozPC1zMkCgbC=> MlHzbY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= Ml7kNlEyPjl{NEK=
SH-EP MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXSxMVEzPSCwTR?= NXH0UXpuOjRvMUKwJIg> NI[xdWpqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l NYP0XJhLOjFzNkmyOFI>
SH-SY5Y NIrnR49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYOxMVEzPSCwTR?= MkXNNlQuOTJyIHi= MYjpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n NHTEfI4zOTF4OUK0Ni=>
SK-N-AS MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nLXVEuOTJ3IH7N MXyyOE0yOjBiaB?= Mlr2bY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= Ml\zNlEyPjl{NEK=
SK-N-BE NY\QcYNXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGi5eYQyNTF{NTDuUS=> M2PXNVI1NTF{MDDo NFzn[m5qdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l NWT3cnpUOjFzNkmyOFI>
KG1 NVnhRWR{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnToNU8yOC9zMECgcm0> Mli5O|IhcA>? MVTEUXNQ NHX0XWhqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l Mn70NVk1PTh|NUi=
U937 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fmPFEwOTBxMUCwJI5O MkTwO|IhcA>? MmDtSG1UVw>? M3zDZolvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZo91cCC2aX3lMUBidmRiZH;z[U1l\XCnbnTlcpQhdWGwbnW= NYHRV3d3OTl2NUizOVg>
CAL62 MojHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXtRYYxNjFvMUCwJI5O NX:xdoY4PzJiaB?= MkPTSG1UVw>? NYqwU3hWTUN3ME2xMlQhdk1? NX3TUFg2OTl{MkO1OVM>
OCUT-1 NYLEb2hzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PqOVAvOS1zMECgcm0> M2\aXFczKGh? NFeydlNFVVOR NVnl[4FXTUN3ME2yMlMhdk1? M3LkXlE6OjJ|NUWz
8505C NH;WN5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLpNE4yNTFyMDDuUS=> NX\EcnBrPzJiaB?= NFfFVVNFVVOR M4DicWVEPTB;Mz6yJI5O M1PBZlE6OjJ|NUWz
ACT-1 NYTld4twT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\1NE4yNTFyMDDuUS=> NF;BfWg4OiCq MlXWSG1UVw>? MYrFR|UxRTVwNDDuUS=> NH3zSYUyQTJ{M{W1Ny=>
SW1736 NICxdHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrWTJI3OC5zLUGwNEBvVQ>? MWq3NkBp MkW3SG1UVw>? MWXFR|UxRTVwNjDuUS=> MoDrNVkzOjN3NUO=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pro-caspase-8 / cleaved caspase-8 / cleaved caspase-3 / cleaved caspase-9; 

PubMed: 27699933     


PLKi‐induced caspase activation. HeLa cells were treated with BI 2536 (10 nmol/L), BI 6727 (68 nmol/L), or GSK461364 (11 nmol/L), and HCT 116 cells were treated with BI 2536 (20 nmol/L), BI 6727 (70 nmol/L), or GSK461364 (12 nmol/L) for 48 h. The levels of cleaved caspase (CASP)‐3, ‐8, and ‐9 were examined by Western blot analysis.

p-HH3 / PARP / Myc / p-Myc; 

PubMed: 24771642     


Western blotting showing more mitotic arrested (shown by phospho-histone H3) and apoptotic (shown by PARP) cells as well as lower MYC levels in LNCaP-Pim1 cells after BI 2536 treatment compared with LNCaP-Neo cells. The difference is obvious at lower dose of BI 2536 (10 nM). Both total MYC expression and phosphor-MYC levels were lower in Pim1 cells than Neo cells after BI 2536 treatment.

pMEK / MEK / pERK / ERK / pRSK1 / RSK1; 

PubMed: 28430578     


(A) and (B) Western blot analysis of the expression and activation of components of the MEK-ERK-RSK1 pathway in MKN45 and MKN74 cancer cells treated with BI 2536 and BI 6727 for 24 and 48 hours, respectively.

pPlk1 / Plk1 / pMyt1; 

PubMed: 28430578     


(A) and (B) Western blot analysis of the expression and phosphorylation of Plk1, and phosphorylation of Myt1 in the CSC-like and cancer cells after treatment with BI 2536 and BI 6727 for 24 and 48 hours, respectively.

Aurora B / pAurora B / pAurora C / pH3 / Cyclin B1 / Securin / pBcl-XL / MPM2; 

PubMed: 25169932     


Western blot analysis of cells treated for 24 h with the indicated inhibitor concentrations. Cell lysates were immunoblotted for Plk1, Phospho-Aurora B (T232)/Aurora C (T198), Aurora B, histone H3 phosphorylated at S10 (pH3), Cdk1, Cyclin B1, Securin, Phospho-Bcl-XL, Induced myeloid leukemia cell differentiation protein Mcl-1, MPM-2 and β-Actin. Left (Hela cells); Right (HUVEC)

27699933 24771642 28430578 25169932
Immunofluorescence
p-H2AX / propidium iodide; 

PubMed: 22309939     


Apoptotic images of the cells after BI 2536 treatment, as revealed by HCS (high-content screening) instrument (×10) with phospho-H2AX antibody or PI (propidium iodide) intake. 

Pericentrin / α-tubulin; 

PubMed: 21772266     


MEFs were labelled using Plk1, pericentrin and α-tubulin antibodies and 4,6-diamidino-2-phenylindole for the analysis by immunofluorescence microscopy. Representative examples of BI 2536-treated and control MEFs are depicted. Scale bar, 5 μm.

22309939 21772266
Growth inhibition assay
Cell viability; 

PubMed: 21772266     


Proliferative activity of MEFs at different BI 2536 concentrations (25–250 nM; means±s.d., n=3, for each concentration). *P<0.05, **P<0.01, ***P<0.001, Student's t-test, unpaired and two-tailed.

21772266
体内研究 BI 2536静脉注射给药多种移植瘤模型,每周一次或两次,效果都很好,通过使细胞周期停滞而抑制细胞增殖,随后诱导肿瘤细胞死亡。BI 2536按 50 mg/kg剂量处理HCT 116移植瘤,每周一次或两次,显著抑制肿瘤生长,T/C 分别为15%和0.3%。BI 2536每周处理两次BxPC-3和A549模型,也显著抑制肿瘤生长,T/C分别为5% 和14%。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验: [1]
- 合并

体外Plk1激酶实验:

重组人Plk1 (1-603残基) 作为氮端,携带杆状病毒表达系统的GST-标记的融合蛋白通过亲和层析,使用谷胱甘肽-琼脂糖而纯化。在梯度稀释的BI 2536存在时,使用 20 ng 重组激酶,及10 μg牛奶中的酪蛋白作为底物进行Plk1 酶活性实验。在终体积为60 μL 的混合物(15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP)中30oC下进行激酶反应45分钟。加入 125 μL 冰冻的5% TCA终止反应。沉淀物转移到混合酯纤维素的多屏过滤板上,使用1% TCA冲洗实验板,然后利用放射性进行测量。绘制剂量反应曲线,而计算IC50值。
细胞实验:[1]
- 合并
  • Cell lines: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji, PC-3,等等
  • Concentrations: 溶于DMSO, 终浓度为~1 μM
  • Incubation Time: 24,和72小时
  • Method: 使用不同浓度BI 2536处理细胞24和72小时。 在荧光分光光度计中测量Alamar Blue染料转换而测定细胞生长。为了测定培养基中DNA含量,细胞悬液在80%乙醇中混合, 使用溶于PBS的0.25% Triton X-100处理5分钟,然后与0.1% RNase 和溶于PBS的 10 μg/mL碘化丙啶在室温下温育20分钟。通过流式细胞仪分析而测定细胞周期谱。
    (Only for Reference)
动物实验:[1]
- 合并
  • Animal Models: 皮下注射HCT 116, NCI-H460, 或A549 细胞的雌性BomTac:NMRI-Foxn1nu 小鼠
  • Formulation: 在盐酸(0.1 N)中配制,然后在0.9% NaCl中稀释。
  • Dosages: ~50 mg/kg
  • Administration: 静脉注射,每周一到两次
    (Only for Reference)

溶解度 (25°C)

体外 Ethanol 100 mg/mL (191.69 mM)
DMSO 21 mg/mL (40.25 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
30% PEG 400+0.5% Tween 80+5% Propylene glycol
15mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 521.66
化学式

C28H39N7O3

CAS号 755038-02-9
储存条件 粉状
溶于溶剂
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02215044 Terminated Drug: BI 2536 intravenous|Drug: Gemcitabine intravenous Pancreatic Neoplasms Boehringer Ingelheim June 2007 Phase 1
NCT02211833 Completed Drug: BI 2536|Drug: Pemetrexed Carcinoma Non-Small-Cell Lung Boehringer Ingelheim October 2006 Phase 1
NCT00701766 Completed Drug: BI 2536 Leukemia Myeloid Acute Boehringer Ingelheim October 2006 Phase 2
NCT00706498 Completed Drug: BI 2536 Prostatic Neoplasms Boehringer Ingelheim September 2006 Phase 2
NCT00376623 Completed Drug: BI 2536 Carcinoma Non-Small-Cell Lung Boehringer Ingelheim July 2006 Phase 2
NCT02211872 Completed Drug: BI 2536 BS intravenous Neoplasms Boehringer Ingelheim August 2004 Phase 1

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?

  • 回答:

    For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

PLK Signaling Pathway Map

PLK Inhibitors with Unique Features

相关PLK产品

Tags: 购买BI 2536 | BI 2536供应商 | 采购BI 2536 | BI 2536价格 | BI 2536生产 | 订购BI 2536 | BI 2536代理商
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID