BI 2536

For research use only. Not for use in humans.

目录号：S1109

CAS No. 755038-02-9

BI-2536是一种有效的Plk1抑制剂，无细胞试验中IC50为0.83 nM。BI-2536可抑制 Bromodomain 4 (BRD4) ，其Kd值为37 nM，并有效地抑制 c-Myc 的表达。BI-2536可诱导凋亡而减弱自噬。Phase 2。

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10mM (1mL in DMSO)	RMB 1978.87	现货
5mg	RMB 981.57	现货
50mg	RMB 5492.59	现货
100mg	RMB 8160.83	现货
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客户使用Selleck生产的BI 2536发表文献239篇：

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PLK抑制剂选择性比较

生物活性

产品描述

特性

BI 2536是第一个有效的Plk1选择性抑制剂，抑制 Plk1的标记。

靶点

c-Myc ^[3] ()	PLK1 ^[1] (Cell-free assay)	PLK2 ^[1] (Cell-free assay)	PLK3 ^[1] (Cell-free assay)	BRD4 ^[3] (Cell-free assay)
	0.83 nM	3.5 nM	9.0 nM	37 nM(Kd)

体外研究

除了Plk1, BI 2536也抑制 Plk2 和Plk3活性，只是抑制程度低点,IC50分别为3.5 nM和9.0 nM。BI 2536比一组63种其他蛋白激酶（IC50>10 μM）选择性高1000多倍。BI 2536 按10 nM 到 100 nM剂量作用于HeLa细胞，抑制有丝分裂中心体中γ-微管蛋白招募和Apc6 磷酸化，抑制染色体臂中释放黏结蛋白, 诱导产生单极主轴，及一些依赖Plk1的其他有丝分裂过程。与作用于Plk1 RNAi效果相一致, BI 2536处理HeLa细胞，使细胞周期停在G2/M期, 随后DNA分解及凋亡，且累积断裂的PARP p85片段，这种作用存在浓度依赖性。BI 2536抑制一组32种人肿瘤细胞系生长，EC50为2-25 nM,抑制指数生长的hTERT-RPE1,人脐静脉内皮细胞 (HUVECs),和正常大鼠肾脏(NRK) 细胞的增殖，EC50为12-31 nM。^[1] BI 2536 抑制Plk1，降低甲状腺未分化癌(ATC)细胞如 CAL62, OCUT-1, SW1736, 8505C,和 ACT-1 的生长的生长和活力，EC50为1.4-5.6 nM。^[2]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
PSN1	Mn[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NWL2VItLUUN3ME2wMlAxPzd4IN88US=>	NVHxUIE3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
ACN	Ml63S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NI\NNYlKSzVyPUCuNFA5PDNizszN	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
TE-8	MmXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NEL2eYZKSzVyPUCuNFA6PDFizszN	M{ja[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
LC-2-ad	MkPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1f5XGlEPTB;MD6wNVA6OyEQvF2=	M3rKeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
ALL-PO	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWfYS3A2UUN3ME2wMlAyOyEQvF2=	MnLQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
EW-16	NHe3[3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3nUfWlEPTB;MD6wNVM{PiEQvF2=	NHHndIk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
KM12	Mn\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2jTSWlEPTB;MD6wNVM1QCEQvF2=	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
GI-1	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M13LeWlEPTB;MD6wNVM5OyEQvF2=	MnPRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
LS-411N	MmHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFzsXpBKSzVyPUCuNFE1ODdizszN	NUL6e4pNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
ES8	MmXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3XjU2lEPTB;MD6wNVQ6PCEQvF2=	NXvUb4Z3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
SNU-C2B	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MkDDTWM2OD1yLkCxOVI3KM7:TR?=	NICybHU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
CESS	NIj5fIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3\lb2lEPTB;MD6wNVYxOiEQvF2=	MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
697	MknqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NUfmPY9wUUN3ME2wMlAyPjZ6IN88US=>	NXzWSIM6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NCI-H1963	MoTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M4jQ[WlEPTB;MD6wNVY4OyEQvF2=	NEW5Omc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
IA-LM	MkPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NF\3WmNKSzVyPUCuNFE3QDhizszN	MoXlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
SW954	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVLJR\|UxRTBwMEG3NFUh\|ryP	NXe5RYpFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
RL95-2	NHvWW4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MorwTWM2OD1yLkCxO\|M5KM7:TR?=	NFS3NXg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
LXF-289	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NX:xZ2F3UUN3ME2wMlAyPzdizszN	M2fzXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
OCUB-M	M4LXO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2O3OmlEPTB;MD6wNVgzPiEQvF2=	NFvZTmc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
RKO	M4nSdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M3HvWmlEPTB;MD6wNVk5PyEQvF2=	NYrBNXQyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
LOUCY	NGHhV5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NHrnb2lKSzVyPUCuNFIxPSEQvF2=	M333eVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
NOS-1	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MkfhTWM2OD1yLkCyNFk{KM7:TR?=	M4jzTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
A4-Fuk	NWS0TWVGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NFr4d2VKSzVyPUCuNFIzOThizszN	M3XBN\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
A388	NX3NcZh3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MleyTWM2OD1yLkCyNlI4KM7:TR?=	NYjjc5lVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
TE-9	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M37nS2lEPTB;MD6wNlI3OSEQvF2=	NFzOXJM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
KURAMOCHI	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MXjJR\|UxRTBwMEKyPFUh\|ryP	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
KALS-1	Mo\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MmnJTWM2OD1yLkCyN\|M5KM7:TR?=	NHzGUm49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
HOP-62	NXzIVXB3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUXaPYZiUUN3ME2wMlAzPDJizszN	NIeyN2I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
RPMI-8402	MojJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2i5SGlEPTB;MD6wNlUxQCEQvF2=	MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
TE-1	M3voR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MoSyTWM2OD1yLkCyOVEzKM7:TR?=	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
CCRF-CEM	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlrETWM2OD1yLkCyOVQ{KM7:TR?=	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
HUTU-80	MlrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1;xe2lEPTB;MD6wNlYzPCEQvF2=	MnzNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NCI-H1648	NYC2VoI3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1fqOmlEPTB;MD6wNlY1PyEQvF2=	MlLhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
HCE-4	Moj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MoH1TWM2OD1yLkCyOlgzKM7:TR?=	NHjSV449[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
ETK-1	NIrCO4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3zuOWlEPTB;MD6wNlc{PiEQvF2=	M{Dmc\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
TE-15	NVH1c5duT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3rweWlEPTB;MD6wNlc{QCEQvF2=	M3WyT\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
BE-13	NEDBOFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MorlTWM2OD1yLkCyO\|Qh\|ryP	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
KE-37	NWHuT2xxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnHOTWM2OD1yLkCyO\|QyKM7:TR?=	NYLlN5FHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NCI-H1355	NEPzbmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MoDBTWM2OD1yLkCyO\|g{KM7:TR?=	M3TVR\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
TE-11	NX;nNmxjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MV3JR\|UxRTBwMEK4NFkh\|ryP	NVzyZVR5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
BL-70	NFLCWYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MUjJR\|UxRTBwMEK4OVch\|ryP	MnTCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
ES6	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWq1fGFSUUN3ME2wMlAzQDhzIN88US=>	NFHSU2E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
GT3TKB	MkOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M{HFRmlEPTB;MD6wNlk2OyEQvF2=	Ml;xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
LB647-SCLC	M1XHTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NWfaZ2NlUUN3ME2wMlA{OTl3IN88US=>	M{PQXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
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BB65-RCC	MlzTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1L4WmlEPTB;MD6xNFI6PCEQvF2=	M2nUUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
DU-4475	MlX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVi0TGhNUUN3ME2wMlExPDB5IN88US=>	NITtdng9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
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SF539	Ml7sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHLTV25KSzVyPUCuOFg3QDRizszN	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
LB2518-MEL	NUe5elI2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3XTTWlEPTB;MD60PVcxOyEQvF2=	M2O5RVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
TE-441-T	MnfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MXPJR\|UxRTBwNUCxNkDPxE1?	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
MDA-MB-134-VI	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NYTkc\|NMUUN3ME2wMlUxQTJzIN88US=>	M{XJT\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
SCC-3	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MojETWM2OD1yLkWxPFc{KM7:TR?=	MnPnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
KLE	NFHp[pJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWrKR2dVUUN3ME2wMlUzOTdzIN88US=>	NETkOZU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
LB2241-RCC	NIGxfYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4\rSGlEPTB;MD61NlUzPSEQvF2=	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
NCI-H1417	NVjWb3h2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M171UGlEPTB;MD61N\|Q{PSEQvF2=	NFfxWHI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NCI-H2081	M4L2Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NX\TdYE3UUN3ME2wMlU5PjFzIN88US=>	NU\CU3N2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NCI-H1522	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUfJR\|UxRTBwNUmzPFMh\|ryP	NI\nZ4c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NCI-H889	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NEDSUVBKSzVyPUCuOVk5PDRizszN	NVSweVhDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
CGTH-W-1	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmLwTWM2OD1yLk[wO\|U2KM7:TR?=	NEPpNlM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
EB-3	M{frcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYjJR\|UxRTBwNkGxOVMh\|ryP	M4DNflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
D-336MG	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M1X3VmlEPTB;MD62NVc6OSEQvF2=	NVTvTIxCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
LC-1F	NXPCZ\|ZrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXXBcm9lUUN3ME2wMlYzPTl{IN88US=>	MmfoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
MHH-NB-11	MnLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M4PqNmlEPTB;MD62N\|gxOSEQvF2=	MoXzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
SK-N-FI	NVHVXYZOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3LMTWlEPTB;MD62N\|kyKM7:TR?=	NFXCSIs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NCI-H69	M2PuVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4fSRWlEPTB;MD62OFg4QSEQvF2=	NHjBOWo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
SCH	NX\kNlNpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MYTJR\|UxRTBwNk[wNlMh\|ryP	Mom2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
LS-513	M2e5b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mkn6TWM2OD1yLk[3NlU6KM7:TR?=	NEfPTVg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
CP67-MEL	NGfzdW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NYP2V49ZUUN3ME2wMlY4PTl4IN88US=>	NVzGV2ZtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
GCIY	MlXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVuxeFhFUUN3ME2wMlcxOzZ\|IN88US=>	NWrt[I5XRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
SHP-77	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWrFZY1{UUN3ME2wMlcxPzN2IN88US=>	M4C5bVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
EHEB	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NGDsfXRKSzVyPUCuO\|E5PTRizszN	NEPoPVk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
D-247MG	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MYnJR\|UxRTBwN{OyN\|Ih\|ryP	NITkUlg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
Raji	NFO0bmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3q5RWlEPTB;MD63OFk5QSEQvF2=	M3\jfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
MPP-89	NWfJPW5MT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnH1TWM2OD1yLke1PVc5KM7:TR?=	M2joN\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
EKVX	NXyyTYg2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MoDvTWM2OD1yLke5NFc{KM7:TR?=	NUO5THVPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
HCC2218	M2HMfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M3XtcWlEPTB;MD63PVE{OSEQvF2=	NGW5SZo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
KNS-81-FD	NH;vXo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NULsVFk5UUN3ME2wMlgyODFzIN88US=>	M{frN\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
HCC2157	MmTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVPJR\|UxRTBwOES5OVEh\|ryP	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
BT-474	MnnPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MWjJR\|UxRTBwOEi4OVQh\|ryP	M4\4clxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
NCI-H748	NVziNWgyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{LFc2lEPTB;MD65NVIh\|ryP	NW\nZ\|dERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
EW-24	NEHhXFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3vMVmlEPTB;MD65NlAxOiEQvF2=	NWrN[oxbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
D-263MG	NYLjd41wT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXjJR\|UxRTBwOUS1NVIh\|ryP	M{PJZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
OMC-1	NYHrRmNbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MVTJR\|UxRTBwOU[zO\|Mh\|ryP	MnzOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NCI-H2196	NHO5b\|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MmT0TWM2OD1yLkm3O\|c4KM7:TR?=	MlLFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
HAL-01	NGXFWGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MYPJR\|UxRTBwOUm4O\|Ih\|ryP	MlzsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NCI-H2107	MlTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3;2dmlEPTB;MT6wNVg2PCEQvF2=	NXPaTZhrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
LB996-RCC	NXTVdI1GT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MkLnTWM2OD1zLkC4NFUyKM7:TR?=	NFy5W3k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NCI-H1395	NGmyWnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVXJSW9iUUN3ME2xMlExPjdizszN	MomyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
CHP-126	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWP3O4x3UUN3ME2xMlE3OTl7IN88US=>	NXywNG5kRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
NB69	M{Pyd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVfIXmdNUUN3ME2xMlI3OTR6IN88US=>	NUC3RpluRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
CAS-1	NFL0NHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVPVZpk1UUN3ME2xMlM1OjNzIN88US=>	NEHwSVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
JVM-3	NES1WWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFi4RW1KSzVyPUGuOFc5PTVizszN	M4\RZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
DMS-153	NXPxW5FbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{K2XWlEPTB;MT61O\|Y4PCEQvF2=	MmDWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
SK-MEL-2	MnfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MkDxTWM2OD1zLkexO\|g6KM7:TR?=	MmL1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NCI-H1155	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2[xOWlEPTB;MT63N\|Y4PiEQvF2=	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
NCI-H1092	NFvueXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MofETWM2OD1zLke2NVgzKM7:TR?=	NVz6OlN1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
LU-165	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWK4[oNZUUN3ME2xMlg3PDd4IN88US=>	M4G4[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
HL-60	NFnnUlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MnXSTWM2OD1zLkm5PVA5KM7:TR?=	MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
REH	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Mn3DTWM2OD1{LkCwOVgzKM7:TR?=	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
JVM-2	M37TNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MlvKTWM2OD1{LkC2NVM2KM7:TR?=	MnfyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
MN-60	NW[5WlRoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NWD1cI5PUUN3ME2yMlE4OzB6IN88US=>	Mn3XQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
SCC-15	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{m2UGlEPTB;Mj6yNFI4KM7:TR?=	NF3rfmM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
SNU-C1	MnmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYLoeoJyUUN3ME2yMlIyOzR\|IN88US=>	MluxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
SK-MEL-1	M1XKemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NXrUS4NTUUN3ME2yMlMzODR5IN88US=>	NFr1[2Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
TGW	M{KzTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Ml:yTWM2OD1{LkO1NFI4KM7:TR?=	NEG0cZo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
CA46	NWLDfXJMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MWLJR\|UxRTJwN{W5Olch\|ryP	M3OzblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
NCI-H23	NYfqWnhrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnPhTWM2OD1{LkiwO\|kyKM7:TR?=	NF3U[4M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
MMAC-SF	NEDGdmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXvlSpNRUUN3ME2yMlg3PjJ6IN88US=>	Ml3YQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NCI-H2171	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4LFZmlEPTB;Mz6wN\|Q1QCEQvF2=	NXHa[nNNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
A704	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlzBTWM2OD1\|LkG0NVk1KM7:TR?=	Mn20QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
DB	MkW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYPJR\|UxRTNwMkW1O\|Yh\|ryP	NGrqW4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NCI-H719	MlPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NEL5cYdKSzVyPUOuN\|A{QDRizszN	M2DlflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
MC-CAR	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MYLJR\|UxRTNwNUS4NVch\|ryP	M2fHSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
SIMA	NVLOUGY6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2\yTGlEPTB;Mz61PFQyPiEQvF2=	NHT6PWw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
SW872	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M33oSmlEPTB;Mz63PFExOSEQvF2=	NXzWXIRyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
HCC1187	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MkH5TWM2OD1\|Lke4N\|E2KM7:TR?=	NXrp[lNvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
EW-13	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4HQU2lEPTB;Mz64N\|QyPyEQvF2=	Mle0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NCI-SNU-1	MkPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVnJR\|UxRTRwMkG5PVkh\|ryP	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
NCI-H226	MknJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mmi0TWM2OD12LkOzOlA3KM7:TR?=	MkDWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
RPMI-8866	M4nHbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2S3SWlEPTB;ND6zOlAzQSEQvF2=	MoLsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
OCI-AML2	NIfFZlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUjBW2J[UUN3ME20MlU2OjNizszN	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
LU-65	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MXTJR\|UxRTRwOUOwN\|Mh\|ryP	NY\IOFJkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
SK-N-DZ	MkTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGnwe4dKSzVyPUWuOlM1PjVizszN	NHnndoI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NB14	NH32foJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M{D3e2lEPTB;NT65O\|E{PSEQvF2=	NE\ofoY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
COLO-829	MmDaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVvJR\|UxRTZwM{OzOVkh\|ryP	NULXcldyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
MHH-CALL-2	M3P6U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXzJR\|UxRTZwNUG1NFgh\|ryP	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
NCI-H1770	NFj3NIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mo\CTWM2OD14Lk[2PVA1KM7:TR?=	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
ECC4	MkDyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NV3vS5E1UUN3ME22MlgzOTd7IN88US=>	M2Pyc\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
A498	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVHJR\|UxRTZwOEexPVIh\|ryP	NED3NWo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
DMS-79	NFj4bWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3qwVmlEPTB;Nz6wOFUyOiEQvF2=	NX;uWo15RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
P30-OHK	M{DFU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MX7JR\|UxRTdwMkG5NFYh\|ryP	NWTVdW12RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
D-502MG	MkW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MWnJR\|UxRTdwOUizOkDPxE1?	NG\Xe3U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
RCC10RGB	Mlr0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NI[xTVhKSzVyPUiuNFYzQCEQvF2=	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
U-698-M	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NUT1XolEUUN3ME24MlI6OjJ4IN88US=>	NX;HZ4FuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
BB49-HNC	M2rVVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFLFbphKSzVyPUmuOFIzPjVizszN	MnSyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
ES1	MlH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYTJR\|UxRTlwNki5OVYh\|ryP	MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
MFM-223	NGfVR\|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MmDhTWM2OD1zMD65PVI4KM7:TR?=	NHK5SoI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
C2BBe1	M{X1TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M3r3T2lEPTB;MUGuN\|UzOyEQvF2=	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
EB2	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Mlj6TWM2OD1zMj62PFgyKM7:TR?=	NXfTOmhFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
C8166	NH3kT\|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MoLCTWM2OD1zMz64N\|A{KM7:TR?=	NUTsWJU{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
ES3	NFn2SJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1myb2lEPTB;MUOuPVk4PyEQvF2=	Mn:yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVE{QTB7Lze+V2FPT0WUPD;hQi=>
NCI-H1650	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M1TsVWlEPTB;MU[uN\|c3PSEQvF2=	NIj3XFc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
Mo-T	NH3veppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NYf2TmM{UUN3ME2xO{41ODJ7IN88US=>	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
NB7	NWHZO2hQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M4HuR2lEPTB;MUeuO\|Q3PyEQvF2=	NVv6T2JORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
ES7	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MoDDTWM2OD1zOT61OVA4KM7:TR?=	MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
ES5	MkLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NV\4S4F2UUN3ME2yNU44PjdzIN88US=>	NHHjVm09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
MSTO-211H	MnnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFfGenVKSzVyPUKxMlg5PThizszN	NXjqcWxoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
U-87-MG	NFruPGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M320[mlEPTB;MkWuNVk3PiEQvF2=	NGLYNWY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
THP-1	NV62RWlZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUnQT\|MxUUN3ME2yPU44OjBzIN88US=>	NGjJN3E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NB10	NWexTnZXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnTCTWM2OD1\|MD6yOlk1KM7:TR?=	NHLLbFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NH-12	NV7Bc\|ZWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHrLVI5KSzVyPUOzMlIxOTdizszN	MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
COLO-824	MlzhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2nGfWlEPTB;M{SuNVAxPiEQvF2=	NF7RTYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
SKM-1	NHj4PHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVXJR\|UxRTN5Lki0NlIh\|ryP	NGf1NG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NCI-H1838	NYfZNZJmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUL0VY01UUN3ME2zPE4{Pzl5IN88US=>	NX2zNZVNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
RL	NVPuPGdIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2q0SWlEPTB;M{muNlQ4PyEQvF2=	NVK1[ploRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
COLO-800	MmLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MoD6TWM2OD12MD6wO\|c{KM7:TR?=	NW\lb4ZIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTF\|OUC5M{c,W0GQR1XSQE9iRg>?
KG-1	MorPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVOxfo9XUUN3ME20NE45QTV3IN88US=>	M3XIOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUyOzlyOT:nQnNCVkeHUkyvZV4>
TUR	NHT2NIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXrQfldKUUN3ME20NU43Ozl7IN88US=>	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
LNCaP-Clone-FGC	Ml7mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2C5VmlEPTB;NEGuPVAyPyEQvF2=	NH7LWlY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OTN7MEmvK\|5USU6JRWK8M4E,
NCI-H322M	NVntNVF7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MVTJR\|UxRTR{LkW5PFQh\|ryP	MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NVM6ODlxJ{7TRW5ITVJ:L3G+
LNCaP	NGfhZmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVjTVIo5UUN3ME25NU4{KG6P	M3nQXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NUC1NVc1Lz5{NUWwOVE4PDxxYU6=
C4-2	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NX3rNG17UUN3ME24JI5O	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTVyNUG3OEc,OjV3MEWxO\|Q9N2F-
JURKAT	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MUeyOEBp		Ml3NTWM2OD12MU[uOlYhdk1?	NWriR45YRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NVk6QTVpPkK0OVE6QTl3PD;hQi=>
MOLT-4	M{PGeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MWiyOEBp		M3HZU2lEPTB;Mki1N{42KG6P	NH\hTXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
REH	MnrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NUPNO\|U1OjRiaB?=		M1rEVmlEPTB;Mki3MlY5KG6P	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
NALM-6	NEi5XGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NEDVcoczPCCq		NFruZ2pKSzVyPUO0N\|MxKG6P	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
RS 4;11	MknQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MnvFNlQhcA>?		MV;JR\|UxRTVzOT6wOUBvVQ>?	MofLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
697	NHLHRWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MkXHNlQhcA>?		NXHLSVVNUUN3ME2yNVA4NjFibl2=	MkTyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
SIL-ALL	NV7w[nBbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		M1HnelI1KGh?		NF7jXIdKSzVyPUG5PU44PyCwTR?=	MmnuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
CEM	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NUjWbnpQOjRiaB?=		MWPJR\|UxRTV{LkG4JI5O	NGP1XGk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
P12	NEnRXHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NVnIN2hGOjRiaB?=		NYHwRZk1UUN3ME2zPU4zPyCwTR?=	MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
NALM-16	NFPa[VJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MmTGNlQhcA>?		NETtd\|ZKSzVyPUm2MlI5KG6P	MlLJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
JURKAT	NG\RfZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NHTSd4M1QCCq		Ml61TWM2OD1zND64OEBvVQ>?	NEPQTGU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
MOLT-4	NW\GV5pRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NInmRpo1QCCq		MVTJR\|UxRTJ4Lk[gcm0>	NH3s[Ig9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
REH	NWHKd2hNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MoPZOFghcA>?		NF3ZNnFKSzVyPUS0MlcyKG6P	Mny4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
NALM-6	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MWW0PEBp		NW\ZUHJwUUN3ME2yN{4zPiCwTR?=	MoDCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MUm5PVUoRjJ2NUG5PVk2RC:jPh?=
RS 4;11	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NFH4dYo1QCCq		NF;yeJZKSzVyPUG2OE4zQCCwTR?=	MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
697	NXPOfYQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NXXZVW96PDhiaB?=		MnLNTWM2OD1\|MEWuN{BvVQ>?	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
SIL-ALL	M4rnTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NUXD[XRNPDhiaB?=		NXrzT4RJUUN3ME23OE43OiCwTR?=	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
CEM	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		M4LvTFQ5KGh?		MVjJR\|UxRTJ2LkW1JI5O	NXTyNXp6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NVk6QTVpPkK0OVE6QTl3PD;hQi=>
P12	NFTFW49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		M33mTVQ5KGh?		Mn7STWM2OD1zOD60OkBvVQ>?	NW[xXXB6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NVk6QTVpPkK0OVE6QTl3PD;hQi=>
NALM-16	NFzGXGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NFHIdY01QCCq		MVvJR\|UxRTZ\|LkK0JI5O	NV;VfpY{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NVk6QTVpPkK0OVE6QTl3PD;hQi=>
JURKAT	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NFfXdYc4OiCq		MXHJR\|UxRTNwNkWgcm0>	NFzmeVc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
MOLT-4	NUjh[YtUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		Mn\uO\|IhcA>?		NX21eIhsUUN3ME23MlM6KG6P	NGS3TZI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
REH	Mnm3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		M3Lqd\|czKGh?		Mn;STWM2OD1zNj6wNUBvVQ>?	MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
NALM-6	M1vxVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NFHrTVM4OiCq		M1j0d2lEPTB;MT63PEBvVQ>?	M{fLb\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
RS 4;11	MnH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NULiXJN6PzJiaB?=		NULSOnhwUUN3ME20MlM5KG6P	M{HmdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUG5PVk2Lz5{NEWxPVk6PTxxYU6=
697	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NVW0WYMyPzJiaB?=		NYLBbZZnUUN3ME23OE4zQCCwTR?=	NIHBdlY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxPVk6PSd-MkS1NVk6QTV:L3G+
SIL-ALL	Mn7hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NULYZVZFPzJiaB?=		MmHSTWM2OD15LkKgcm0>	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
CEM	NGrPUJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		M{DZSlczKGh?		NXLjcYVqUUN3ME21MlQzKG6P	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
P12	Mon4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MVy3NkBp		Ml[yTWM2OD14LkO3JI5O	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
NALM-16	NXu1eldCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NV7BcpQ6PzJiaB?=		NW[zdHFxUUN3ME23O{44OyCwTR?=	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzOUm5OUc,OjR3MUm5PVU9N2F-
Y79	NX;UbFluSXCxcITvd4l{KEG\|c3H5	NHjDT4kyNTVyIH7N	M1K5cVEzNzJ2IHi=	MYjEUXNQ	Mn3TbY5lfWOnZDDhdI9xfG:\|aYOge4hq[2hiY3HuJIJmKGWwaHHuZ4VlKGK7IFjU	MkTVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR\|Nk[2OlUoRjJ2M{[2OlY2RC:jPh?=
WER-Rb-1	M1zOb2Fxd3C2b4Ppd{BCe3OjeR?=	M{Lpe\|EuPTBibl2=	NF;lcJMyOi9{NDDo	NUDuO\|NmTE2VTx?=	MVvpcoR2[2WmIHHwc5B1d3OrczD3bIlkcCClYX6gZoUh\W6qYX7j[YQh[nliSGS=	MkPSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR\|Nk[2OlUoRjJ2M{[2OlY2RC:jPh?=
G7	NFH1e3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MoD3TWM2OD1\|LkOgcm0>	M2DyWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MkC0O\|M{Lz5{NEKwOFc{OzxxYU6=
G166	M{\DeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1jobmlEPTB;Nz6wJI5O	MnWyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{MES3N\|MoRjJ2MkC0O\|M{RC:jPh?=
CB660	M3vMeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mnv4TWM2OD14LkSgcm0>	M13QS\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MkC0O\|M{Lz5{NEKwOFc{OzxxYU6=
CB1117	NIHKSllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXzJR\|UxRTF3Lk[gcm0>	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDJyNEezN{c,OjR{MES3N\|M9N2F-
KB-3-1	NXntUlR7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnOwTWM2OD1zLkS4JOKyKDBwNUOgcm0>	NVfVSGxJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5OlI1PDVpPkKzPVYzPDR3PD;hQi=>
KB-8-5-11	MmXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVjJR\|UxRTVwMEGgxtEhOi5yMTDuUS=>	NX7FWlFjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5OlI1PDVpPkKzPVYzPDR3PD;hQi=>
KB-C-1	NYXDfpdUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXqwSXRPUUN3ME2xOk44PiEEsTC0MlUyKG6P	MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4MkS0OUc,OjN7NkK0OFU9N2F-
KB-V-1	NXj0cFE1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXvJR\|UxRTJ6MT6yOEDDuSB\|MT61O{BvVQ>?	Mn:1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkK0OFUoRjJ\|OU[yOFQ2RC:jPh?=
OVCAR-8	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NXvHXpZ7UUN3ME23MlE6KMLzIEOuOlAhdk1?	M2jzRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OU[yOFQ2Lz5{M{m2NlQ1PTxxYU6=
NCI-ADR-RES	MoXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYPJR\|UxRTF{N{OuN\|AhyrFiMUmxMlIxKG6P	M2TNe\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OU[yOFQ2Lz5{M{m2NlQ1PTxxYU6=
MCF7	NX\ld3BoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{fsZWlEPTB;NT6xNUDDuSBzLkS3JI5O	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4MkS0OUc,OjN7NkK0OFU9N2F-
MCF7-FLV1000	M{jDO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MUXJR\|UxRTN7Mz6xPEDDuSB5ND64N{BvVQ>?	NWLQZnBXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5OlI1PDVpPkKzPVYzPDR3PD;hQi=>
S1	Mm\sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGDMdlFKSzVyPUK0MlMxKMLzIESuO\|Uhdk1?	NITvNXg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2NlQ1PSd-MkO5OlI1PDV:L3G+
S1-M1-80	NFzoNoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3;lRmlEPTB;Mk[xMlA3KMLzIES4MlI2KG6P	MmLTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkK0OFUoRjJ\|OU[yOFQ2RC:jPh?=
CORL-23/P	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnX2TWM2OD12LkO4JOKyKDFwMkWgcm0>	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4MkS0OUc,OjN7NkK0OFU9N2F-
CORL-23/R	M4HlT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYPJR\|UxRTVwMU[gxtEhOS56MzDuUS=>	M4HObVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OU[yOFQ2Lz5{M{m2NlQ1PTxxYU6=
NIH3T3	MkjuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MknSTWM2OD12MD62NEDDuSB2Lkm3JI5O	M4P4blxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OU[yOFQ2Lz5{M{m2NlQ1PTxxYU6=
NIH3T3-G185	NEPBZVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mk\jTWM2OD1{NEGzMlQxKMLzIESyN{43PiCwTR?=	NH6xfpo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2NlQ1PSd-MkO5OlI1PDV:L3G+
pcDNA-HEK293	NXXtc5MxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NYfqZpA2UUN3ME2yMlc2KMLzIECuOlchdk1?	NXvObZBlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5OlI1PDVpPkKzPVYzPDR3PD;hQi=>
MDR19-HEK293	NUH6fWZ5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{nDZ2lEPTB;OEWuOVAhyrFiMUOuOlchdk1?	M2K0S\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OU[yOFQ2Lz5{M{m2NlQ1PTxxYU6=
R482-HEK293	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MkDsTWM2OD1{NT65O{DDuSB2Lkm1JI5O	Mk[5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkK0OFUoRjJ\|OU[yOFQ2RC:jPh?=
MRP1-HEK293	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NUSzT3RCUUN3ME2yMlk6KMLzIEGuOFkhdk1?	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4MkS0OUc,OjN7NkK0OFU9N2F-
SF188	NH3vZVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXPKPFdCOTBvMUCwJI5O	MWmyOE06PiCq	M1Hib2ROW09?	NGO1eHpqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDic5RpKHSrbXWtJIFv\CClb37j[Y51emG2aX;uMUBl\XCnZHXueEBu[W6wZYK=	Mnf0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6OEe2OFUoRjJ\|OEi3OlQ2RC:jPh?=
T98G	MomyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NV3EWY93OTBvMUCwJI5O	NEHVRW4zPC17NjDo	MWnEUXNQ	MnzmbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iY3;uZ4VvfHKjdHnvck0h\GWyZXTlcpQhdWGwbnXy	NYXWS\|VXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4PFc3PDVpPkKzPFg4PjR3PD;hQi=>
DU145	M1HOPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			Ml25SG1UVw>?	Mom2TWM2OOLKvE[wJI5O	NVz0T5FQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4PFQ1OjhpPkKzPFg1PDJ6PD;hQi=>
LNCaP	NFHWfpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MlnhSG1UVw>?	NFvqcoRKSzVy4pk8O\|Uhdk1?	MmTsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6OES0NlgoRjJ\|OEi0OFI5RC:jPh?=
PC3	NYTQZ28yT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MYjEUXNQ	MX7JR\|Ux6oj:MUe1JI5O	MmK5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6OES0NlgoRjJ\|OEi0OFI5RC:jPh?=
RT4	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Mnm1TWM2OD1{Nz6yNUBvVQ>?	NHfkTlg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{e5NlY{QSd-MkO3PVI3Ozl:L3G+
5637	Mo\3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M4fFT2lEPTB;NEWuOFchdk1?	MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd7Mk[zPUc,OjN5OUK2N\|k9N2F-
T24	NULBR\|c5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NVfyWnZVUUN3ME23PU4yOiCwTR?=	MmDvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5OUK2N\|koRjJ\|N{myOlM6RC:jPh?=
MCF7	M2fYVmZ2dmO2aX;uJGF{e2G7	NGrTVFUyODBibl2=	M3;GVVEhcA>?	NX[2SZRDTE2VTx?=	NY\2VG5NemWmdXPld{B1cGViaX7keYN1cW:wIH;mxsBIemWkMT\|CpHNoczFuwrDQd\|ItyqCVZYLwbY5iOyxiYX7kxsBYcXOyMh?=	NG\JfZE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{e3NFI1PCd-MkO3O\|AzPDR:L3G+
KB-V1	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Ml7UTWM2OD1\|LkmyJO69VQ>?	NYDyVHlnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1PVMyQTZpPkKzOVk{OTl4PD;hQi=>
Hec50co	NHnIZnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MYLJR\|UxRTVibl2=	Ml\DQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNzNE[2PFcoRjJ\|MUS2Olg4RC:jPh?=
MDA-MB-468	NVTXTpczSXCxcITvd4l{KEG\|c3H5	M1\OelEwPS9zMDDuUS=>	MlK4NlQwPDhxN{KgbC=>	M17oWmROW09?	MlKzbY5lfWOnczDhdI9xfG:\|aYOgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK=	MmLCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNzNESyPVQoRjJ\|MUS0Nlk1RC:jPh?=
MCF10A	MnjDRZBweHSxc3nzJGF{e2G7	MV:xM\|UwOTBibl2=	NE\ONXMzPC92OD:3NkBp	MnnhSG1UVw>?	NHj3TpNqdmS3Y3XzJIFxd3C2b4Ppd{BqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=>	NWKzflVTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOxOFQzQTRpPkKzNVQ1Ojl2PD;hQi=>
Huh-7	M3TOOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVSxM\|ExNzFyMD:xNFAxKG6P	NVyzfXlTPDhiaB?=		M1y5XIRm[3KnYYPld{B1cGViY3XscEB3cWGkaXzpeJkh\G:\|ZT3k[ZBmdmSnboTsfS=>	NYn6coxsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK3OFU2QDdpPkKyO\|Q2PTh5PD;hQi=>
Daoy	NYL5Z5NjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHz6e5YyNjh5NT2yOFAhdk1?	M2qyTVczKGh?	NFLZ[I1FVVOR	M4X1e2lEPTB;NTDuUS=>	M1vES\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{mwNlc6Lz5{MkO5NFI4QTxxYU6=
ONS-76	MoXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3m5bFEvQDd3LUK0NEBvVQ>?	MnLxO\|IhcA>?	M1zyOmROW09?	M1v5OWlEPTB;Nz61JI5O	NGTzZmI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkO5NFI4QSd-MkKzPVAzPzl:L3G+
SUM 149	M2LRTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmDBNE0yODBibl2=	MnzRO\|IhcA>?		NUjIRlRbcW6qaXLpeJMhfGinIHPlcIwhfmmjYnnsbZR6KGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoFz	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjNyOUmzPUc,OjJ\|MEm5N\|k9N2F-
MDA-MB-231	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NV;kcXZROC1zMECgcm0>	NG\aO\|g4OiCq		NF7CTXRqdmirYnn0d{B1cGViY3XscEB3cWGkaXzpeJkhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7uZZI>	MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjNyOUmzPUc,OjJ\|MEm5N\|k9N2F-
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OHS-50	NWHF[m9reUiWUzDhd5NigQ>?				NVy0cWlOeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IF;IV{02OCClZXzsdy=>	NVXqO2JqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
BT-12	M3f6fpFJXFNiYYPzZZk>				Mlv6dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgRnQuOTJiY3XscJM>	NWPXeoZ1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
LAN-5	MYnxTHRUKGG\|c3H5				Mn\FdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgUGFPNTViY3XscJM>	M{LaSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
Fibroblast cells	M1nZeJFJXFNiYYPzZZk>				Mo\VdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKGOxboTyc4whUGhid3ns[EB1gXCnIH\pZpJw[myjc4SgZ4VtdHN?	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
NB-EBc1	M2XjWpFJXFNiYYPzZZk>				M3\iXJFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJG5DNUWEY{GgZ4VtdHN?	NHTqdHg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
SK-N-SH	M{TEc5FJXFNiYYPzZZk>				MmqxdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgV2suVi2VSDDj[Yxtew>?	NVPkU21ZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
A673	M2PqeZFJXFNiYYPzZZk>				NYLkbXF{eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhSTZ5MzDj[Yxteyl?	NVu3bZk5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
BT-37	M{DBPZFJXFNiYYPzZZk>				M{mzTZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJGJVNTN5IHPlcIx{	NHLVTIM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
MG 63(6-TG R)	NF;k[npyUFSVIHHzd4F6				NGLV[nVyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBOTyB4MzCoOk1VTyCUKTDj[Yxtew>?	MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
Fibroblast cells	NVO3cZNKeUiWUzDhd5NigQ>?				M2jWOpFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJINwdnS{b3ygTIghf2muZDD0fZBmKG[rYoLvZoxie3RiY3XscJM>	MlS1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
OHS-50	M3HoNJFJXFNiYYPzZZk>				NG\aR4hyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBQUFNvNUCgZ4VtdHN?	NX3MNJZZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
RD	M1vNVZFJXFNiYYPzZZk>				MnP1dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgVmQh[2WubIO=	NY\KSIFbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
SJ-GBM2	NE[5cVJyUFSVIHHzd4F6				Mn7pdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKFOMLVfCUVIh[2WubIO=	M4PrOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SK-N-MC	MVPxTHRUKGG\|c3H5				MWTxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhW0tvTj3NR{Bk\Wyucx?=	Mlf6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
NB-EBc1	MkO4dWhVWyCjc4PhfS=>				MX;xTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhVkJvRVLjNUBk\Wyucx?=	M4LFS\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
LAN-5	M4X6V5FJXFNiYYPzZZk>				MYjxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhVEGQLUWgZ4VtdHN?	NYPVdpBJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
Rh18	M3HBb5FJXFNiYYPzZZk>				NIq2[FdyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiUnixPEBk\Wyucx?=	NH7NPHY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
NB1643	Mn7SdWhVWyCjc4PhfS=>				M{WyPJFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJG5DOTZ2MzDj[Yxtew>?	NX:weI9nRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
SK-N-MC	NXTKOGg1eUiWUzDhd5NigQ>?				NUPk[29XeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhW0tvTj3NR{Bk\Wyucx?=	M1TGRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SJ-GBM2	NGfkeHlyUFSVIHHzd4F6				NIjMXYdyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBUUi2JQl2yJINmdGy\|	M1XuVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
TC32	M3PIcZFJXFNiYYPzZZk>				MkHPdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgWGM{OiClZXzsdy=>	NEHOOI09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
Rh18	NF7zWpJyUFSVIHHzd4F6				MmG0dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgVogyQCClZXzsdy=>	NHTJ[4E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
Saos-2	MkLHdWhVWyCjc4PhfS=>				NV;qc5BoeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhW2Gxcz2yJINmdGy\|	M2PMdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
DU145	NV73[FdnSXCxcITvd4l{KGG\|c3H5	NHLhSHQyODBibl2=	MoO1NlQhcHK\|		NIjMOXpKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m\|IHnuJIh2dWGwIFTVNVQ2KGOnbHzzJIF{e2W\|c3XkJIF{KGmwY4LlZZNmKGmwIGDBVnAh[2ynYY\h[4Uh[XRiMUCwJI5OKGGodHXyJFI1KGi{czDifUBqdW23bn;icI91fGmwZzDt[ZRpd2R?	MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ6NUm0NUc,OjV4OEW5OFE9N2F-
HeLa	M37nXWZ2dmO2aX;uJIF{e2G7	NUHpfXJsOTByIH7N			M4rkPWlvcGmkaYTpc44hd2ZiUFzLNUBVcHJ{MUCgdIhwe3Cqb4L5cIF1cW:wIHnuJIh2dWGwIFjlUIEh[2WubIOgZZQhOTByIH7NJIJ6KGmvbYXuc4Jtd3S2aX7nJI1mfGixZB?=	NWjXOIttRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2PFU6PDFpPkK1Olg2QTRzPD;hQi=>
DU145	MWnGeY5kfGmxbjDhd5NigQ>?	NYLDSGo{OTByIH7N			MlHaTY5pcWKrdHnvckBw\iCSTFuxJJBzd3SnaX6gZYNkfW23bHH0bY9vKGmwIHj1cYFvKESXMUS1JINmdGy\|IHH0JFExOCCwTTDifUBqdW23bn;icI91fGmwZzDt[ZRpd2R?	NWfuN\|JkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2PFU6PDFpPkK1Olg2QTRzPD;hQi=>
HeLa	Ml[5SpVv[3Srb36gZZN{[Xl?	MmfZNVAxKG6P			MlHUTY5pcWKrdHnvckBw\iCSTFuxJJBzd3SnaX6gZYNkfW23bHH0bY9vKGmwIHj1cYFvKEinTHGgZ4VtdHNiYYSgNVAxKG6PIHL5JIludXWwb3Lsc5R1cW6pIH3leIhw\A>?	NWDvUo5KRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2PFU6PDFpPkK1Olg2QTRzPD;hQi=>
HeLa	MmXYSpVv[3Srb36gZZN{[Xl?	NXz2NGtIOTByIH7N	M3XESlE5KGi{cx?=		M2HXemlv\HWldHnvckBw\iCvb37vdI9t[XJibXn0c5Rq[yC\|cHnu[IxmeyCrbjDoeY1idiCKZVzhJINmdGy\|IHH0JFExOCCwTTDpcoN2[mG2ZXSg[o9zKDF6IHjyd{BjgSCrbnTpdoVkfCCrbX31co9ndHWxcnXzZ4Vv[2VibXnjdo9{[2:yeR?=	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ6NUm0NUc,OjV4OEW5OFE9N2F-
HeLa	MYXBdI9xfG:\|aYOgZZN{[Xl?	Moe1NVAxKG6P	MWKyOEBpenN?		Mom1TY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCKZVzhJINmdGy\|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKFCDUmCgZ4xm[X[jZ3WgZZQhOTByIH7NJIFnfGW{IEK0JIhzeyCkeTDpcY12dm:kbH;0eIlv\yCvZYToc4Q>	NGftUFE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[4OVk1OSd-MkW2PFU6PDF:L3G+
PC3	M{\sZmZ2dmO2aX;uJIF{e2G7	NFH4Z\|MyODBibl2=	M{juNlE5KGi{cx?=		MV\JcoR2[3Srb36gc4YhdW:wb4DvcIFzKG2rdH;0bYMhe3CrbnTs[ZMhcW5iaIXtZY4hWEN\|IHPlcIx{KGG2IEGwNEBvVSCrbnP1ZoF1\WRiZn;yJFE5KGi{czDifUBqdmSrcnXjeEBqdW23bn;mcJVwemW\|Y3XuZ4UhdWmlcn;zZ49xgQ>?	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ6NUm0NUc,OjV4OEW5OFE9N2F-
DU145	M1Gwb2Z2dmO2aX;uJIF{e2G7	NHnydG8yODBibl2=			NXT5UJA4UW6qaXLpeIlwdiCxZjDQUGsyKFSqckKxNEBxcG:\|cHjvdplt[XSrb36gbY4hcHWvYX6gSHUyPDViY3XscJMh[XRiMUCwJI5OKGK7IHntcZVvd2Kub4T0bY5oKG2ndHjv[C=>	NESzTmk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[4OVk1OSd-MkW2PFU6PDF:L3G+

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Assay

Methods	Test Index	PMID
Western blot	pro-caspase-8 / cleaved caspase-8 / cleaved caspase-3 / cleaved caspase-9; PubMed: 27699933 Cancer Sci PLKi‐induced caspase activation. HeLa cells were treated with BI 2536 (10 nmol/L), BI 6727 (68 nmol/L), or GSK461364 (11 nmol/L), and HCT 116 cells were treated with BI 2536 (20 nmol/L), BI 6727 (70 nmol/L), or GSK461364 (12 nmol/L) for 48 h. The levels of cleaved caspase (CASP)‐3, ‐8, and ‐9 were examined by Western blot analysis. p-HH3 / PARP / Myc / p-Myc; PubMed: 24771642 Clin Cancer Res Western blotting showing more mitotic arrested (shown by phospho-histone H3) and apoptotic (shown by PARP) cells as well as lower MYC levels in LNCaP-Pim1 cells after BI 2536 treatment compared with LNCaP-Neo cells. The difference is obvious at lower dose of BI 2536 (10 nM). Both total MYC expression and phosphor-MYC levels were lower in Pim1 cells than Neo cells after BI 2536 treatment. pMEK / MEK / pERK / ERK / pRSK1 / RSK1; PubMed: 28430578 Oncotarget (A) and (B) Western blot analysis of the expression and activation of components of the MEK-ERK-RSK1 pathway in MKN45 and MKN74 cancer cells treated with BI 2536 and BI 6727 for 24 and 48 hours, respectively. pPlk1 / Plk1 / pMyt1; PubMed: 28430578 Oncotarget (A) and (B) Western blot analysis of the expression and phosphorylation of Plk1, and phosphorylation of Myt1 in the CSC-like and cancer cells after treatment with BI 2536 and BI 6727 for 24 and 48 hours, respectively. Aurora B / pAurora B / pAurora C / pH3 / Cyclin B1 / Securin / pBcl-XL / MPM2; PubMed: 25169932 Mol Oncol Western blot analysis of cells treated for 24 h with the indicated inhibitor concentrations. Cell lysates were immunoblotted for Plk1, Phospho-Aurora B (T232)/Aurora C (T198), Aurora B, histone H3 phosphorylated at S10 (pH3), Cdk1, Cyclin B1, Securin, Phospho-Bcl-XL, Induced myeloid leukemia cell differentiation protein Mcl-1, MPM-2 and β-Actin. Left (Hela cells); Right (HUVEC)	27699933 24771642 28430578 25169932
Immunofluorescence	p-H2AX / propidium iodide; PubMed: 22309939 Breast Cancer Res Apoptotic images of the cells after BI 2536 treatment, as revealed by HCS (high-content screening) instrument (×10) with phospho-H2AX antibody or PI (propidium iodide) intake. Pericentrin / α-tubulin; PubMed: 21772266 Nat Commun MEFs were labelled using Plk1, pericentrin and α-tubulin antibodies and 4,6-diamidino-2-phenylindole for the analysis by immunofluorescence microscopy. Representative examples of BI 2536-treated and control MEFs are depicted. Scale bar, 5 μm.	22309939 21772266
Growth inhibition assay	Cell viability; PubMed: 21772266 Nat Commun Proliferative activity of MEFs at different BI 2536 concentrations (25–250 nM; means±s.d., n=3, for each concentration). P<0.05, P<0.01, **P<0.001, Student's t-test, unpaired and two-tailed.	21772266

体内研究

BI 2536静脉注射给药多种移植瘤模型，每周一次或两次，效果都很好，通过使细胞周期停滞而抑制细胞增殖，随后诱导肿瘤细胞死亡。BI 2536按 50 mg/kg剂量处理HCT 116移植瘤，每周一次或两次，显著抑制肿瘤生长，T/C 分别为15%和0.3%。BI 2536每周处理两次BxPC-3和A549模型，也显著抑制肿瘤生长，T/C分别为5% 和14%。^[1]

激酶实验： ^[1]	- 合并体外Plk1激酶实验: 重组人Plk1 (1-603残基) 作为氮端，携带杆状病毒表达系统的GST-标记的融合蛋白通过亲和层析，使用谷胱甘肽-琼脂糖而纯化。在梯度稀释的BI 2536存在时，使用 20 ng 重组激酶，及10 μg牛奶中的酪蛋白作为底物进行Plk1 酶活性实验。在终体积为60 μL 的混合物(15 mM MgCl₂, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-³³P-ATP)中30^oC下进行激酶反应45分钟。加入 125 μL 冰冻的5% TCA终止反应。沉淀物转移到混合酯纤维素的多屏过滤板上，使用1% TCA冲洗实验板，然后利用放射性进行测量。绘制剂量反应曲线，而计算IC50值。
细胞实验： ^[1]	- 合并 Cell lines: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji, PC-3,等等 Concentrations: 溶于DMSO, 终浓度为~1 μM Incubation Time: 24,和72小时 Method: 使用不同浓度BI 2536处理细胞24和72小时。在荧光分光光度计中测量Alamar Blue染料转换而测定细胞生长。为了测定培养基中DNA含量，细胞悬液在80%乙醇中混合, 使用溶于PBS的0.25% Triton X-100处理5分钟，然后与0.1% RNase 和溶于PBS的 10 μg/mL碘化丙啶在室温下温育20分钟。通过流式细胞仪分析而测定细胞周期谱。 (Only for Reference)
动物实验： ^[1]	- 合并 Animal Models: 皮下注射HCT 116, NCI-H460, 或A549 细胞的雌性BomTac:NMRI-Foxn1nu 小鼠 Dosages: ~50 mg/kg Administration: 静脉注射，每周一到两次 (Only for Reference)

参考文献

溶解度 (25°C)

体外	Ethanol	100 mg/mL (191.69 mM)
	DMSO	21 mg/mL (40.25 mM)
	Water	Insoluble
体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： 5%DMSO+40%PEG300+5%Tween80+50%ddH2O	12.5mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download BI 2536 SDF

分子量	521.66
化学式	C₂₈H₃₉N₇O₃
CAS号	755038-02-9
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	N/A

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

临床试验信息 (data from https://clinicaltrials.gov, updated on 2021-05-17)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT02215044	Terminated	Drug: BI 2536 intravenous\|Drug: Gemcitabine intravenous	Pancreatic Neoplasms	Boehringer Ingelheim	June 2007	Phase 1
NCT02211833	Completed	Drug: BI 2536\|Drug: Pemetrexed	Carcinoma Non-Small-Cell Lung	Boehringer Ingelheim	October 2006	Phase 1
NCT00701766	Completed	Drug: BI 2536	Leukemia Myeloid Acute	Boehringer Ingelheim	October 2006	Phase 2
NCT00706498	Completed	Drug: BI 2536	Prostatic Neoplasms	Boehringer Ingelheim	September 2006	Phase 2
NCT00376623	Completed	Drug: BI 2536	Carcinoma Non-Small-Cell Lung	Boehringer Ingelheim	July 2006	Phase 2
NCT02211872	Completed	Drug: BI 2536 BS intravenous	Neoplasms	Boehringer Ingelheim	August 2004	Phase 1

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

常见问题及建议解决方法

问题 1：
We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?
回答：
For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

PLK Signaling Pathway Map

PLK Inhibitors with Unique Features

选择性强的Plk抑制剂

GSK461364 : Plk1-selective, K_i=2.2 nM.
用于临床的Plk抑制剂

Rigosertib (ON-01910) : Phase III for Myelo Dysplastic Syndrome (MDS).
最新的Plk抑制剂

Ro3280 ^New : Potent, highly selective inhibitor of Polo-like kinase 1 (PLK1) with IC50 of 3 nM.
经典的Plk抑制剂

Volasertib (BI 6727) : Highly potent Plk1 inhibitor with IC50 of 0.87 nM and in phase II trials.

研究领域

产品类型

定制您的化合物库

BI 2536

客户使用Selleck生产的BI 2536发表文献239篇：

产品安全说明书

PLK抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download BI 2536 SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

临床试验信息 (data from https://clinicaltrials.gov, updated on 2021-05-17)

技术支持

常见问题及建议解决方法

PLK Signaling Pathway Map

PLK Inhibitors with Unique Features

相关PLK产品