BI 2536

For research use only. Not for use in humans.

目录号:S1109

BI 2536 Chemical Structure

Molecular Weight(MW): 521.66

BI-2536是一种有效的Plk1抑制剂,无细胞试验中IC50为0.83 nM。BI-2536可抑制 Bromodomain 4 (BRD4) ,其Kd值为37 nM,并有效地抑制 c-Myc 的表达。BI-2536可诱导凋亡而减弱自噬。Phase 2。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1978.87 现货
RMB 981.57 现货
RMB 1704.35 现货
RMB 5492.59 现货
RMB 8160.83 现货
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客户使用Selleck生产的BI 2536发表文献160篇:

产品安全说明书

PLK抑制剂选择性比较

生物活性

产品描述 BI-2536是一种有效的Plk1抑制剂,无细胞试验中IC50为0.83 nM。BI-2536可抑制 Bromodomain 4 (BRD4) ,其Kd值为37 nM,并有效地抑制 c-Myc 的表达。BI-2536可诱导凋亡而减弱自噬。Phase 2。
特性 BI 2536是第一个有效的Plk1选择性抑制剂,抑制 Plk1的标记。
靶点
PLK1 [1]
(Cell-free assay)
PLK2 [1]
(Cell-free assay)
PLK3 [1]
(Cell-free assay)
0.83 nM 3.5 nM 9.0 nM
体外研究

除了Plk1, BI 2536也抑制 Plk2 和Plk3活性,只是抑制程度低点,IC50分别为3.5 nM和9.0 nM。BI 2536比一组63种其他蛋白激酶(IC50>10 μM)选择性高1000多倍。BI 2536 按10 nM 到 100 nM剂量作用于HeLa细胞,抑制有丝分裂中心体中γ-微管蛋白招募和Apc6 磷酸化,抑制染色体臂中释放黏结蛋白, 诱导产生单极主轴,及一些依赖Plk1的其他有丝分裂过程。与作用于Plk1 RNAi效果相一致, BI 2536处理HeLa细胞,使细胞周期停在G2/M期, 随后DNA分解及凋亡,且累积断裂的PARP p85片段,这种作用存在浓度依赖性。BI 2536抑制一组32种人肿瘤细胞系生长,EC50为2-25 nM,抑制指数生长的hTERT-RPE1,人脐静脉内皮细胞 (HUVECs),和正常大鼠肾脏(NRK) 细胞的增殖,EC50为12-31 nM。[1] BI 2536 抑制Plk1,降低甲状腺未分化癌(ATC)细胞如 CAL62, OCUT-1, SW1736, 8505C,和 ACT-1 的生长的生长和活力,EC50为1.4-5.6 nM。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PSN1 NETTOlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnqTWM2OD1yLkCwO|c3KM7:TR?= MoD5V2FPT0WU
ACN NHjHXnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzXNoVKSzVyPUCuNFA5PDNizszN MknoV2FPT0WU
TE-8 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvhTWM2OD1yLkCwPVQyKM7:TR?= NIjEbmtUSU6JRWK=
LC-2-ad NVXLXJZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTBwMEGwPVMh|ryP M1nrdHNCVkeHUh?=
ALL-PO NGm3cVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoP1TWM2OD1yLkCxN{DPxE1? NUHsTpU1W0GQR1XS
EW-16 MnzSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojZTWM2OD1yLkCxN|M3KM7:TR?= MVPTRW5ITVJ?
KM12 M2TzVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWntXYNwUUN3ME2wMlAyOzR6IN88US=> NIPPdnFUSU6JRWK=
GI-1 NVHGXXFQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXmySJp[UUN3ME2wMlAyOzh|IN88US=> M1u5XnNCVkeHUh?=
LS-411N MmHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDXTWM2OD1yLkCxOFA4KM7:TR?= NUf2PJVJW0GQR1XS
ES8 NVG3epg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwMEG0PVQh|ryP NGrObJNUSU6JRWK=
SNU-C2B MlnTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmezTWM2OD1yLkCxOVI3KM7:TR?= NGTsfIxUSU6JRWK=
CESS M{fVNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{O3e2lEPTB;MD6wNVYxOiEQvF2= NXmwNmJoW0GQR1XS
697 Mnj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XuZmlEPTB;MD6wNVY3QCEQvF2= MYXTRW5ITVJ?
NCI-H1963 Mn;CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvnS453UUN3ME2wMlAyPjd|IN88US=> NI[1clZUSU6JRWK=
IA-LM NGDLSoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTBwMEG2PFgh|ryP NYXIOJJOW0GQR1XS
SW954 NES5VXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fTWmlEPTB;MD6wNVcxPSEQvF2= MVvTRW5ITVJ?
RL95-2 M2fUWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3W0XWlEPTB;MD6wNVc{QCEQvF2= MYTTRW5ITVJ?
LXF-289 M1P2Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2T6PWlEPTB;MD6wNVc4KM7:TR?= MVTTRW5ITVJ?
OCUB-M Mn\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEe2coFKSzVyPUCuNFE5OjZizszN MWfTRW5ITVJ?
RKO M4LoRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HaT2lEPTB;MD6wNVk5PyEQvF2= MWDTRW5ITVJ?
LOUCY NV[5Tm9NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTBwMEKwOUDPxE1? MmX0V2FPT0WU
NOS-1 NVXHd2hwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrXboRKSzVyPUCuNFIxQTNizszN MoTIV2FPT0WU
A4-Fuk M{LLfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLObVVKSzVyPUCuNFIzOThizszN M{LJNXNCVkeHUh?=
A388 M1\Mbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwMEKyNlch|ryP M3P5[XNCVkeHUh?=
TE-9 Ml\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX[0NJVrUUN3ME2wMlAzOjZzIN88US=> M2[1TnNCVkeHUh?=
KURAMOCHI M{Lmc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfHTWM2OD1yLkCyNlg2KM7:TR?= NWfU[Zp2W0GQR1XS
KALS-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTBwMEKzN|gh|ryP NFm0WpFUSU6JRWK=
HOP-62 M4mxc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwMEK0NkDPxE1? MmnnV2FPT0WU
RPMI-8402 M3jzXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTBwMEK1NFgh|ryP M2i3[nNCVkeHUh?=
TE-1 M3nhXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jLZWlEPTB;MD6wNlUyOiEQvF2= NFriU5ZUSU6JRWK=
CCRF-CEM MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwMEK1OFMh|ryP M1\rfnNCVkeHUh?=
HUTU-80 NIS4VldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfNRZhKSzVyPUCuNFI3OjRizszN NWTpUZVJW0GQR1XS
NCI-H1648 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzrTWM2OD1yLkCyOlQ4KM7:TR?= M3j5VHNCVkeHUh?=
HCE-4 M17oSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXNUY9SUUN3ME2wMlAzPjh{IN88US=> MkjiV2FPT0WU
ETK-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTBwMEK3N|Yh|ryP NVfRSmVQW0GQR1XS
TE-15 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTITWM2OD1yLkCyO|M5KM7:TR?= NGTOW5pUSU6JRWK=
BE-13 M4fjRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\3WGlEPTB;MD6wNlc1KM7:TR?= MULTRW5ITVJ?
KE-37 M1PCUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULtWJBVUUN3ME2wMlAzPzRzIN88US=> M4\kcnNCVkeHUh?=
NCI-H1355 MoqxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7RTWM2OD1yLkCyO|g{KM7:TR?= NGXOZmZUSU6JRWK=
TE-11 M1TQfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWT3dJl7UUN3ME2wMlAzQDB7IN88US=> MUDTRW5ITVJ?
BL-70 MoroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorvTWM2OD1yLkCyPFU4KM7:TR?= M3fzeHNCVkeHUh?=
ES6 NGSzRW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLBTWM2OD1yLkCyPFgyKM7:TR?= NXjNbnBnW0GQR1XS
GT3TKB NV;LZo1KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTBwMEK5OVMh|ryP M3rGSnNCVkeHUh?=
LB647-SCLC MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\TcG9LUUN3ME2wMlA{OTl3IN88US=> MXvTRW5ITVJ?
NB13 MnXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwMEOzNVYh|ryP M4ixUXNCVkeHUh?=
ST486 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1Ls[mlEPTB;MD6wN|M{PyEQvF2= Mk\kV2FPT0WU
NCI-H82 NXrJ[nN7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwMEOzOFMh|ryP M33VbHNCVkeHUh?=
NTERA-S-cl-D1 MmLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTBwMEOzPVkh|ryP MmTEV2FPT0WU
ES4 MkO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4Xy[GlEPTB;MD6wN|Q3OyEQvF2= M4Pq[HNCVkeHUh?=
SK-NEP-1 M3jGUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMEO0PVkh|ryP MkTPV2FPT0WU
Becker Mlz6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPaN5dKSzVyPUCuNFM2PTVizszN M3\hbHNCVkeHUh?=
A101D MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjQXVhJUUN3ME2wMlA{PzR6IN88US=> MmS4V2FPT0WU
SK-UT-1 NV\sSWx4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwMEO3O|Qh|ryP NXjvV5dqW0GQR1XS
SW982 NIjTPHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\1WVFKSzVyPUCuNFM4QSEQvF2= MY\TRW5ITVJ?
TE-10 MlOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;pRoNKSzVyPUCuNFQxPDZizszN NU\iXIZHW0GQR1XS
OVCAR-4 NFTDO3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPDTWM2OD1yLkC0NFU6KM7:TR?= M2nLSnNCVkeHUh?=
KP-N-YS M33BU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHZTWM2OD1yLkC0NFg2KM7:TR?= NUXROHc3W0GQR1XS
BL-41 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVz0b4ZkUUN3ME2wMlA1OTJ3IN88US=> NEPxPZhUSU6JRWK=
MZ1-PC MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NICyTHZKSzVyPUCuNFQyOjdizszN MULTRW5ITVJ?
PF-382 NEW1N3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1ezdmlEPTB;MD6wOFE6QCEQvF2= MYfTRW5ITVJ?
MOLT-13 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{T0XGlEPTB;MD6wOFI{QCEQvF2= NFvKUZJUSU6JRWK=
HCC1599 MknMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjpTWM2OD1yLkC0NlU5KM7:TR?= NFTiZ2tUSU6JRWK=
IST-MEL1 NV:1ZmFNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLaTWM2OD1yLkC0OFQzKM7:TR?= M4DLbnNCVkeHUh?=
LU-139 NEDaUo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHP6fXBKSzVyPUCuNFQ1PDJizszN M1LlPHNCVkeHUh?=
MS-1 M3XieGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrXTWM2OD1yLkC0O|AyKM7:TR?= M4T0NXNCVkeHUh?=
MFH-ino NE\MOIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3r5Z2lEPTB;MD6wOVAxOyEQvF2= NWTmNJBsW0GQR1XS
IMR-5 Ml7tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTNd|RKSzVyPUCuNFUxOjFizszN NYLrSZRIW0GQR1XS
TE-5 MkHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXNTWM2OD1yLkC1NFY{KM7:TR?= NXrtOmdUW0GQR1XS
DJM-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrhPJM3UUN3ME2wMlA2OTR{IN88US=> M{nmbHNCVkeHUh?=
NB17 NYfnflhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn[yTWM2OD1yLkC1NlA4KM7:TR?= M1ewV3NCVkeHUh?=
KARPAS-45 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVf0[HNVUUN3ME2wMlA2OzV6IN88US=> NFfaV4RUSU6JRWK=
TGBC1TKB M{LPO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIK1eXVKSzVyPUCuNFU1ODVizszN MmL2V2FPT0WU
ML-2 NXvRUos3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwMEW0NVQh|ryP NIHFOoNUSU6JRWK=
no-10 NUnrXVk1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTBwMEW0O|Qh|ryP NHfKO2VUSU6JRWK=
CTV-1 NF\ZWoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwMEW1NFIh|ryP NYr2[IhjW0GQR1XS
SJSA-1 M3HNNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIT2U4VKSzVyPUCuNFU2OiEQvF2= MnPyV2FPT0WU
HC-1 M1THZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\0XWlEPTB;MD6wOVU6PyEQvF2= NE\CZXFUSU6JRWK=
TE-12 Ml2xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTBwMEW2NVMh|ryP MYPTRW5ITVJ?
KY821 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPlbXl[UUN3ME2wMlA2PjN{IN88US=> NYf1eYN1W0GQR1XS
TALL-1 M{LkNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HpcWlEPTB;MD6wOVcxQCEQvF2= MnjiV2FPT0WU
DEL MmXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwMEW3NFkh|ryP NHXmc5BUSU6JRWK=
TE-6 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{G1UWlEPTB;MD6wOVczOiEQvF2= MXvTRW5ITVJ?
SK-LMS-1 M{XNNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{K2N2lEPTB;MD6wOVgxPSEQvF2= NEf2W3dUSU6JRWK=
EW-1 MlLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHtRXdKSzVyPUCuNFU5OzdizszN MlLPV2FPT0WU
8-MG-BA MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zRWmlEPTB;MD6wOVg2OSEQvF2= MofyV2FPT0WU
NALM-6 M2nLWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfHTWM2OD1yLkC1PVc{KM7:TR?= NF[0RmhUSU6JRWK=
LB771-HNC M3rS[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm[1TWM2OD1yLkC1PVc6KM7:TR?= M3\Wb3NCVkeHUh?=
HT-144 NID0dWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLLT5hKSzVyPUCuNFYyOyEQvF2= MnfXV2FPT0WU
KM-H2 MoLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jNW2lEPTB;MD6wOlIzOSEQvF2= MUfTRW5ITVJ?
SF268 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXQTWM2OD1yLkC2Nlg3KM7:TR?= NUTM[4dvW0GQR1XS
RS4-11 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkf4TWM2OD1yLkC2N|A1KM7:TR?= MYHTRW5ITVJ?
MHH-PREB-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXP4V5VXUUN3ME2wMlA3OzF7IN88US=> MkjNV2FPT0WU
ATN-1 MnTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwME[zOFUh|ryP NWDaXGdZW0GQR1XS
BB30-HNC MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnqcoZmUUN3ME2wMlA3PDN4IN88US=> MYjTRW5ITVJ?
CPC-N MkC4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnPPXlKSzVyPUCuNFY2OjRizszN MVzTRW5ITVJ?
NB1 M3r0NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\EOmlEPTB;MD6wOlYyOyEQvF2= NEnJe3BUSU6JRWK=
KS-1 NIHm[IpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHkNmhKSzVyPUCuNFY4PDhizszN NIG3cJFUSU6JRWK=
RXF393 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mon1TWM2OD1yLkC2O|Y1KM7:TR?= NI\wPFlUSU6JRWK=
IST-SL2 M1foXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwMEewNFQh|ryP NFnEXZVUSU6JRWK=
GI-ME-N Mle0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrvfY5KSzVyPUCuNFczQDZizszN MnXHV2FPT0WU
VA-ES-BJ MoL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;GUHVKSzVyPUCuNFc1PzVizszN M2e4fXNCVkeHUh?=
NCI-H1581 NEHPVFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7yTWM2OD1yLkC3OFc5KM7:TR?= NHvZbJVUSU6JRWK=
U-266 NHjvXlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwMEe0PVch|ryP MYLTRW5ITVJ?
DMS-114 MoTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTBwMEe1Nlgh|ryP NEfPSnBUSU6JRWK=
NCI-H187 NFnBTFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\iTWM2OD1yLkC3O|I3KM7:TR?= M3fkRnNCVkeHUh?=
SW962 NXnS[nFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEW4WG1KSzVyPUCuNFc5OzlizszN Mni2V2FPT0WU
MONO-MAC-6 MoL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\WTWM2OD1yLkC3PVg3KM7:TR?= MljuV2FPT0WU
MOLT-16 M1HlUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnTeHJKSzVyPUCuNFgyOjFizszN MkG1V2FPT0WU
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COLO-668 NUTheJF2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLaZpI4UUN3ME2wMlQ2PjZ6IN88US=> NX\vZnA3W0GQR1XS
SF539 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFy5W5FKSzVyPUCuOFg3QDRizszN Mn;vV2FPT0WU
LB2518-MEL NHzBeHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTBwNEm3NFMh|ryP MWXTRW5ITVJ?
TE-441-T NXzHRXZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwNUCxNkDPxE1? MVrTRW5ITVJ?
MDA-MB-134-VI Mon3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTBwNUC5NlEh|ryP MXjTRW5ITVJ?
SCC-3 NV7tdZFXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTBwNUG4O|Mh|ryP MUXTRW5ITVJ?
KLE NEDWO5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTBwNUKxO|Eh|ryP NWPXcWRqW0GQR1XS
LB2241-RCC M{fkVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjuZ4RKSzVyPUCuOVI2OjVizszN M4S5bXNCVkeHUh?=
NCI-H1417 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnTTWM2OD1yLkWzOFM2KM7:TR?= Mm\CV2FPT0WU
NCI-H2081 M3;SZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVe4UZQ4UUN3ME2wMlU5PjFzIN88US=> NELPd3lUSU6JRWK=
NCI-H1522 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo[3TWM2OD1yLkW5N|g{KM7:TR?= MUfTRW5ITVJ?
NCI-H889 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDFZVR3UUN3ME2wMlU6QDR2IN88US=> MYXTRW5ITVJ?
CGTH-W-1 NF[3RlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfJR49IUUN3ME2wMlYxPzV3IN88US=> NYH4THJIW0GQR1XS
EB-3 MlfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{j6OGlEPTB;MD62NVE2OyEQvF2= MkTuV2FPT0WU
D-336MG M2\TSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTBwNkG3PVEh|ryP MljoV2FPT0WU
LC-1F NXjQ[GtCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjTW2xKSzVyPUCuOlI2QTJizszN NGPXV|hUSU6JRWK=
MHH-NB-11 MnPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml:3TWM2OD1yLk[zPFAyKM7:TR?= NWXiWXBTW0GQR1XS
SK-N-FI MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{izRmlEPTB;MD62N|kyKM7:TR?= NFXWZY5USU6JRWK=
NCI-H69 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTBwNkS4O|kh|ryP MXPTRW5ITVJ?
SCH M4f4cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwNk[wNlMh|ryP NYfJPI95W0GQR1XS
LS-513 M4jjcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfRNHpKSzVyPUCuOlczPTlizszN NGfFSVVUSU6JRWK=
CP67-MEL M1S2[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDLfm9KSzVyPUCuOlc2QTZizszN M4HVW3NCVkeHUh?=
GCIY MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jmZ2lEPTB;MD63NFM3OyEQvF2= NVS4UJR7W0GQR1XS
SHP-77 NVTYd2k4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTBwN{C3N|Qh|ryP NHv3PHVUSU6JRWK=
EHEB M4XZ[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXq3eWZEUUN3ME2wMlcyQDV2IN88US=> MXjTRW5ITVJ?
D-247MG MofKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXz[JNKSzVyPUCuO|MzOzJizszN M{\FVnNCVkeHUh?=
Raji M{HJO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWK5fXVIUUN3ME2wMlc1QTh7IN88US=> MoXQV2FPT0WU
MPP-89 NGK0[3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXIV2pKSzVyPUCuO|U6PzhizszN NFvLTZJUSU6JRWK=
EKVX MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmD6TWM2OD1yLke5NFc{KM7:TR?= NXroU3ZqW0GQR1XS
HCC2218 NULzfYxrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vyWmlEPTB;MD63PVE{OSEQvF2= NHTiUopUSU6JRWK=
KNS-81-FD NI\LNJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLIepBmUUN3ME2wMlgyODFzIN88US=> MVLTRW5ITVJ?
HCC2157 MoPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWC2bm9RUUN3ME2wMlg1QTVzIN88US=> NIK5TWVUSU6JRWK=
BT-474 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHxc|dFUUN3ME2wMlg5QDV2IN88US=> M4[5enNCVkeHUh?=
NCI-H748 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfKU|ZKSzVyPUCuPVEzKM7:TR?= MlvVV2FPT0WU
EW-24 NVfjOWU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LIU2lEPTB;MD65NlAxOiEQvF2= MlqxV2FPT0WU
D-263MG NVTaTJA6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjnZmpKSzVyPUCuPVQ2OTJizszN MlXPV2FPT0WU
OMC-1 M{jmdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvFdlZKSzVyPUCuPVY{PzNizszN MnixV2FPT0WU
NCI-H2196 MorNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTBwOUe3O|ch|ryP NXuwNJp{W0GQR1XS
HAL-01 M3rEfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHuyVYRKSzVyPUCuPVk5PzJizszN M2jLOHNCVkeHUh?=
NCI-H2107 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTFwMEG4OVQh|ryP NU[xfodlW0GQR1XS
LB996-RCC NVfvfmFZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TVTWlEPTB;MT6wPFA2OSEQvF2= M1TDXHNCVkeHUh?=
NCI-H1395 MlrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjiVYpKSzVyPUGuNVA3PyEQvF2= MVPTRW5ITVJ?
CHP-126 NU\LV2lvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fjUGlEPTB;MT6xOlE6QSEQvF2= NHv1fWtUSU6JRWK=
NB69 NUHLdnFqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzRN4YzUUN3ME2xMlI3OTR6IN88US=> MlrKV2FPT0WU
CAS-1 NXfUN2VwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnPTWM2OD1zLkO0NlMyKM7:TR?= M2rY[nNCVkeHUh?=
JVM-3 NHPGfGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTFwNEe4OVUh|ryP M{XwZnNCVkeHUh?=
DMS-153 NGPTVpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;kNZpKSzVyPUGuOVc3PzRizszN NUj2d3ZQW0GQR1XS
SK-MEL-2 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGm0[olKSzVyPUGuO|E4QDlizszN MUnTRW5ITVJ?
NCI-H1155 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nRZmlEPTB;MT63N|Y4PiEQvF2= M3P0UHNCVkeHUh?=
NCI-H1092 MkTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jDdGlEPTB;MT63OlE5OiEQvF2= NFPL[YpUSU6JRWK=
LU-165 NHfrVVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPB[GZDUUN3ME2xMlg3PDd4IN88US=> MX\TRW5ITVJ?
HL-60 MmrJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnpRVB5UUN3ME2xMlk6QTB6IN88US=> Mnu3V2FPT0WU
REH NHfmbINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTJwMEC1PFIh|ryP Mn3qV2FPT0WU
JVM-2 M{X3RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlW1TWM2OD1{LkC2NVM2KM7:TR?= M1TqTXNCVkeHUh?=
MN-60 NX6xdYRZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;BXHNzUUN3ME2yMlE4OzB6IN88US=> NWLPe2JsW0GQR1XS
SCC-15 M1u4UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHRTWM2OD1{LkKwNlch|ryP NYX5UmZFW0GQR1XS
SNU-C1 NGLLdJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mle1TWM2OD1{LkKxN|Q{KM7:TR?= NWK1[4h2W0GQR1XS
SK-MEL-1 NVzIcW9WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTJwM{KwOFch|ryP NUDJdlU6W0GQR1XS
TGW MoHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTJwM{WwNlch|ryP MUnTRW5ITVJ?
CA46 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITacHRKSzVyPUKuO|U6PjdizszN MVTTRW5ITVJ?
NCI-H23 NWTI[llbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\hRodbUUN3ME2yMlgxPzlzIN88US=> NWjwUXR6W0GQR1XS
MMAC-SF NVfTdXpoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfGR3lKSzVyPUKuPFY3OjhizszN MXzTRW5ITVJ?
NCI-H2171 M{TwdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXGTWM2OD1|LkCzOFQ5KM7:TR?= NYLXWG96W0GQR1XS
A704 MlP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{j1UGlEPTB;Mz6xOFE6PCEQvF2= M1n3XXNCVkeHUh?=
DB MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljhTWM2OD1|LkK1OVc3KM7:TR?= M13YU3NCVkeHUh?=
NCI-H719 NHSyNFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHlNYJlUUN3ME2zMlMxOzh2IN88US=> M{D4VnNCVkeHUh?=
MC-CAR M{e5cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTNwNUS4NVch|ryP MmLnV2FPT0WU
SIMA M3jQWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fKcWlEPTB;Mz61PFQyPiEQvF2= NWLSOIpXW0GQR1XS
SW872 M3TJeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rQRWlEPTB;Mz63PFExOSEQvF2= NI\DXG1USU6JRWK=
HCC1187 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkn1TWM2OD1|Lke4N|E2KM7:TR?= MVzTRW5ITVJ?
EW-13 NELQ[YpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7xdll2UUN3ME2zMlg{PDF5IN88US=> MVzTRW5ITVJ?
NCI-SNU-1 MlrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPUcIF2UUN3ME20MlIyQTl7IN88US=> NFnUfGdUSU6JRWK=
NCI-H226 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTRwM{O2NFYh|ryP NHH2WWlUSU6JRWK=
RPMI-8866 MofPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLuTWM2OD12LkO2NFI6KM7:TR?= M17hW3NCVkeHUh?=
OCI-AML2 NUDEWpg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTxWoFqUUN3ME20MlU2OjNizszN Mmn5V2FPT0WU
LU-65 NEXNPJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEKy[lJKSzVyPUSuPVMxOzNizszN NXrONJBzW0GQR1XS
SK-N-DZ NX3KXlhrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX6ycoRHUUN3ME21MlY{PDZ3IN88US=> M{ntbnNCVkeHUh?=
NB14 MkXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4Toc2lEPTB;NT65O|E{PSEQvF2= NWXs[HNZW0GQR1XS
COLO-829 NX\mdm5KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojLTWM2OD14LkOzN|U6KM7:TR?= M1zUR3NCVkeHUh?=
MHH-CALL-2 NGXlflVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jDVmlEPTB;Nj61NVUxQCEQvF2= Ml:wV2FPT0WU
NCI-H1770 M4\tSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnn0TWM2OD14Lk[2PVA1KM7:TR?= Mn\xV2FPT0WU
ECC4 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorOTWM2OD14LkiyNVc6KM7:TR?= M1TmV3NCVkeHUh?=
A498 NYfkUoFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGKz[2VKSzVyPU[uPFcyQTJizszN M3XCOXNCVkeHUh?=
DMS-79 M1v2NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTwWpRUUUN3ME23MlA1PTF{IN88US=> M{fOOHNCVkeHUh?=
P30-OHK NX6wOJFQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljlTWM2OD15LkKxPVA3KM7:TR?= NEfKOpZUSU6JRWK=
D-502MG NXK1cVd1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVj3UIdOUUN3ME23Mlk5OzZizszN NYPMdW9xW0GQR1XS
RCC10RGB Mk\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTtNJNGUUN3ME24MlA3OjhizszN NInoZmFUSU6JRWK=
U-698-M M2LySGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXaTWM2OD16LkK5NlI3KM7:TR?= NFvZ[3lUSU6JRWK=
BB49-HNC NGfI[WdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTlwNEKyOlUh|ryP NGGyVHpUSU6JRWK=
ES1 NHLRXFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPsTWRKSzVyPUmuOlg6PTZizszN MlK2V2FPT0WU
MFM-223 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTFyLkm5Nlch|ryP NUXGcZpnW0GQR1XS
C2BBe1 NXzhbIlxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfhTWM2OD1zMT6zOVI{KM7:TR?= M4nsTHNCVkeHUh?=
EB2 Mn7yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLNXVBKSzVyPUGyMlY5QDFizszN NGfXTllUSU6JRWK=
C8166 NVXpUphbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV:1OGdRUUN3ME2xN{45OzB|IN88US=> NUnrOI04W0GQR1XS
ES3 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XqOmlEPTB;MUOuPVk4PyEQvF2= MoXaV2FPT0WU
NCI-H1650 NXrZVlJvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjhTWM2OD1zNj6zO|Y2KM7:TR?= M1HpTnNCVkeHUh?=
Mo-T M{LvVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;oTWM2OD1zNz60NFI6KM7:TR?= M4HmdHNCVkeHUh?=
NB7 NGOzVYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHmVXNRUUN3ME2xO{44PDZ5IN88US=> NXS5RmFXW0GQR1XS
ES7 NXz6dZpET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU[5TJdoUUN3ME2xPU42PTB5IN88US=> NUi5dmp{W0GQR1XS
ES5 NVLUZWVIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGOxOHZKSzVyPUKxMlc3PzFizszN M2r4e3NCVkeHUh?=
MSTO-211H MnLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPhRpBKSzVyPUKxMlg5PThizszN M3;mbHNCVkeHUh?=
U-87-MG MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHDPZNKSzVyPUK1MlE6PjZizszN MoHoV2FPT0WU
THP-1 NXzOTYhYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTJ7LkeyNFEh|ryP NE\OUWVUSU6JRWK=
NB10 MmXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzqPWtKSzVyPUOwMlI3QTRizszN NIPG[4FUSU6JRWK=
NH-12 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXL1WIlXUUN3ME2zN{4zODF5IN88US=> NYDZXZVkW0GQR1XS
COLO-824 NYDS[4RzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\PT2VKSzVyPUO0MlExODZizszN NVrhfG13W0GQR1XS
SKM-1 NVjGeVFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;MT254UUN3ME2zO{45PDJ{IN88US=> MYHTRW5ITVJ?
NCI-H1838 M{mwbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTISllKSzVyPUO4MlM4QTdizszN NXHEW2s2W0GQR1XS
RL MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\lTWM2OD1|OT6yOFc4KM7:TR?= M2m2PHNCVkeHUh?=
COLO-800 NEHtcpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3r0UmlEPTB;NECuNFc4OyEQvF2= MWTTRW5ITVJ?
KG-1 NWHzZ2VkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1X2WmlEPTB;NECuPFk2PSEQvF2= M1HEWHNCVkeHUh?=
TUR NVH1TnpWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2j3cWlEPTB;NEGuOlM6QSEQvF2= NHu2bFRUSU6JRWK=
LNCaP-Clone-FGC NIDQTIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXSWnhKSzVyPUSxMlkxOTdizszN MYHTRW5ITVJ?
NCI-H322M MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDTbINKSzVyPUSyMlU6QDRizszN MVXTRW5ITVJ?
LNCaP  NHfs[pdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3SyR2lEPTB;OUGuN{BvVQ>? NGjUTm0zPTVyNUG3OC=>
C4-2 M3PieWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1:wS2lEPTB;ODDuUS=> NWLoc|U1OjV3MEWxO|Q>
JURKAT M4n3d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXeyOEBp MkjxTWM2OD12MU[uOlYhdk1? MlLKNlQ2OTl7OUW=
MOLT-4 NUXId5d6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfEZWxTOjRiaB?= M13IOWlEPTB;Mki1N{42KG6P NUXCfFlwOjR3MUm5PVU>
REH M1LudWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX2yOEBp MnzvTWM2OD1{OEeuOlghdk1? M1TCVVI1PTF7OUm1
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ACHN NF7RUoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWG1MVgxKG6P MmjTPVYhcA>? M13ldGhEdA>? M4K4b5N2eHC{ZYPz[ZMhfGinIIDyc4xq\mW{YYTpc44hcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZIhf2m2aDDJR|UxyqC4YXz1[ZMhd2ZiMjD0c{AzOCCwTR?= MUWyNVY1OjN5NB?=
Caki-1 M2[5Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzWOU05OCCwTR?= Moi1PVYhcA>? M1zMR2hEdA>? M3XDdJN2eHC{ZYPz[ZMhfGinIIDyc4xq\mW{YYTpc44hcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZIhf2m2aDDJR|UxyqC4YXz1[ZMhd2ZiMjD0c{AzOCCwTR?= NHWxRoszOTZ2MkO3OC=>
SN12C MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nrdFUuQDBibl2= MUe5OkBp M3vhWWhEdA>? NV7HNJd4e3WycILld5NmeyC2aHWgdJJwdGmoZYLheIlwdiCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meiC5aYToJGlEPTEEoI\hcJVmeyCxZjCyJJRwKDJyIH7N M{HGRlIyPjR{M{e0
HMC-1.1 NF[yS2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3ubnY1OS1zMECwJI5O MUO3NkBp Ml7kbY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5m NYPKOZp1OjF{NEKxPFk>
HMC-1.2 NXWzUnZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjnNU0yODByIH7N MXS3NkBp MkLEbY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5m MWqyNVI1OjF6OR?=
C2 M1PHU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjMNU0yODByIH7N NVfXUHJlPzJiaB?= NFu0VWRqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmV? MlW4NlEzPDJzOEm=
CHP-212 Mn30S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXuxMVEzPSCwTR?= NUjjfIh1OjRvMUKwJIg> MmrQbY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= MnvhNlEyPjl{NEK=
IMR-32 M3PaWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXf3[GhoOS1zMkWgcm0> NED0b|kzPC1zMkCgbC=> NFnHd5NqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l NUn1W3VkOjFzNkmyOFI>
Kelly NYjrenBHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVGxWllTOS1zMkWgcm0> MXWyOE0yOjBiaB?= MVfpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n MVqyNVE3QTJ2Mh?=
SH-EP NV\pZ4ttT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PPe|EuOTJ3IH7N MV[yOE0yOjBiaB?= NEPL[GtqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l MWmyNVE3QTJ2Mh?=
SH-SY5Y MlOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DkUVEuOTJ3IH7N NFXtSVUzPC1zMkCgbC=> M4\rdYlvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZo91cCC2aX3lMUBidmRiZH;z[U1l\XCnbnTlcpQhdWGwbnW= M1;yeVIyOTZ7MkSy
SK-N-AS NX3sdpE3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3w[oIyNTF{NTDuUS=> MX2yOE0yOjBiaB?= NETONnVqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l MWGyNVE3QTJ2Mh?=
SK-N-BE NGG1[5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;DV|EyNTF{NTDuUS=> NITaR|EzPC1zMkCgbC=> MXvpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n MkjHNlEyPjl{NEK=
KG1 MoL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfGNU8yOC9zMECgcm0> NGfYclk4OiCq M3Tsb2ROW09? M1nOfolvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZo91cCC2aX3lMUBidmRiZH;z[U1l\XCnbnTlcpQhdWGwbnW= MVSxPVQ2QDN3OB?=
U937 NETt[WRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV:3RmxQOS9zMD:xNFAhdk1? M{LRWVczKGh? MXnEUXNQ MXPpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n NXX2XpZxOTl2NUizOVg>
CAL62 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX6wMlEuOTByIH7N MlrqO|IhcA>? Ml2ySG1UVw>? NF7GOmJGSzVyPUGuOEBvVQ>? M1\iZ|E6OjJ|NUWz
OCUT-1 M{HZNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnj3NE4yNTFyMDDuUS=> M4i3bVczKGh? NFXXdo9FVVOR MWXFR|UxRTJwMzDuUS=> MlXvNVkzOjN3NUO=
8505C M2Hte2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWKwMlEuOTByIH7N M13xVVczKGh? NILNbZlFVVOR NGmzcndGSzVyPUOuNkBvVQ>? MmD1NVkzOjN3NUO=
ACT-1 M1\GPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHqNE4yNTFyMDDuUS=> MkDXO|IhcA>? NWLiNotjTE2VTx?= MYfFR|UxRTVwNDDuUS=> NVvkfZNqOTl{MkO1OVM>
SW1736 MlzGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUWwMlEuOTByIH7N MV23NkBp M{jTcGROW09? M3nKfWVEPTB;NT62JI5O MkHhNVkzOjN3NUO=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pro-caspase-8 / cleaved caspase-8 / cleaved caspase-3 / cleaved caspase-9; 

PubMed: 27699933     


PLKi‐induced caspase activation. HeLa cells were treated with BI 2536 (10 nmol/L), BI 6727 (68 nmol/L), or GSK461364 (11 nmol/L), and HCT 116 cells were treated with BI 2536 (20 nmol/L), BI 6727 (70 nmol/L), or GSK461364 (12 nmol/L) for 48 h. The levels of cleaved caspase (CASP)‐3, ‐8, and ‐9 were examined by Western blot analysis.

p-HH3 / PARP / Myc / p-Myc; 

PubMed: 24771642     


Western blotting showing more mitotic arrested (shown by phospho-histone H3) and apoptotic (shown by PARP) cells as well as lower MYC levels in LNCaP-Pim1 cells after BI 2536 treatment compared with LNCaP-Neo cells. The difference is obvious at lower dose of BI 2536 (10 nM). Both total MYC expression and phosphor-MYC levels were lower in Pim1 cells than Neo cells after BI 2536 treatment.

pMEK / MEK / pERK / ERK / pRSK1 / RSK1; 

PubMed: 28430578     


(A) and (B) Western blot analysis of the expression and activation of components of the MEK-ERK-RSK1 pathway in MKN45 and MKN74 cancer cells treated with BI 2536 and BI 6727 for 24 and 48 hours, respectively.

pPlk1 / Plk1 / pMyt1; 

PubMed: 28430578     


(A) and (B) Western blot analysis of the expression and phosphorylation of Plk1, and phosphorylation of Myt1 in the CSC-like and cancer cells after treatment with BI 2536 and BI 6727 for 24 and 48 hours, respectively.

Aurora B / pAurora B / pAurora C / pH3 / Cyclin B1 / Securin / pBcl-XL / MPM2; 

PubMed: 25169932     


Western blot analysis of cells treated for 24 h with the indicated inhibitor concentrations. Cell lysates were immunoblotted for Plk1, Phospho-Aurora B (T232)/Aurora C (T198), Aurora B, histone H3 phosphorylated at S10 (pH3), Cdk1, Cyclin B1, Securin, Phospho-Bcl-XL, Induced myeloid leukemia cell differentiation protein Mcl-1, MPM-2 and β-Actin. Left (Hela cells); Right (HUVEC)

27699933 24771642 28430578 25169932
Immunofluorescence
p-H2AX / propidium iodide; 

PubMed: 22309939     


Apoptotic images of the cells after BI 2536 treatment, as revealed by HCS (high-content screening) instrument (×10) with phospho-H2AX antibody or PI (propidium iodide) intake. 

Pericentrin / α-tubulin; 

PubMed: 21772266     


MEFs were labelled using Plk1, pericentrin and α-tubulin antibodies and 4,6-diamidino-2-phenylindole for the analysis by immunofluorescence microscopy. Representative examples of BI 2536-treated and control MEFs are depicted. Scale bar, 5 μm.

22309939 21772266
Growth inhibition assay
Cell viability; 

PubMed: 21772266     


Proliferative activity of MEFs at different BI 2536 concentrations (25–250 nM; means±s.d., n=3, for each concentration). *P<0.05, **P<0.01, ***P<0.001, Student's t-test, unpaired and two-tailed.

21772266
体内研究 BI 2536静脉注射给药多种移植瘤模型,每周一次或两次,效果都很好,通过使细胞周期停滞而抑制细胞增殖,随后诱导肿瘤细胞死亡。BI 2536按 50 mg/kg剂量处理HCT 116移植瘤,每周一次或两次,显著抑制肿瘤生长,T/C 分别为15%和0.3%。BI 2536每周处理两次BxPC-3和A549模型,也显著抑制肿瘤生长,T/C分别为5% 和14%。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验: [1]
- 合并

体外Plk1激酶实验:

重组人Plk1 (1-603残基) 作为氮端,携带杆状病毒表达系统的GST-标记的融合蛋白通过亲和层析,使用谷胱甘肽-琼脂糖而纯化。在梯度稀释的BI 2536存在时,使用 20 ng 重组激酶,及10 μg牛奶中的酪蛋白作为底物进行Plk1 酶活性实验。在终体积为60 μL 的混合物(15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP)中30oC下进行激酶反应45分钟。加入 125 μL 冰冻的5% TCA终止反应。沉淀物转移到混合酯纤维素的多屏过滤板上,使用1% TCA冲洗实验板,然后利用放射性进行测量。绘制剂量反应曲线,而计算IC50值。
细胞实验:[1]
- 合并
  • Cell lines: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji, PC-3,等等
  • Concentrations: 溶于DMSO, 终浓度为~1 μM
  • Incubation Time: 24,和72小时
  • Method: 使用不同浓度BI 2536处理细胞24和72小时。 在荧光分光光度计中测量Alamar Blue染料转换而测定细胞生长。为了测定培养基中DNA含量,细胞悬液在80%乙醇中混合, 使用溶于PBS的0.25% Triton X-100处理5分钟,然后与0.1% RNase 和溶于PBS的 10 μg/mL碘化丙啶在室温下温育20分钟。通过流式细胞仪分析而测定细胞周期谱。
    (Only for Reference)
动物实验:[1]
- 合并
  • Animal Models: 皮下注射HCT 116, NCI-H460, 或A549 细胞的雌性BomTac:NMRI-Foxn1nu 小鼠
  • Dosages: ~50 mg/kg
  • Administration: 静脉注射,每周一到两次
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 21 mg/mL (40.25 mM)
Water Insoluble
Ethanol '100 mg/mL
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
30% PEG 400+0.5% Tween 80+5% Propylene glycol
15mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 521.66
化学式

C28H39N7O3

CAS号 755038-02-9
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02215044 Terminated Drug: BI 2536 intravenous|Drug: Gemcitabine intravenous Pancreatic Neoplasms Boehringer Ingelheim June 2007 Phase 1
NCT02211833 Completed Drug: BI 2536|Drug: Pemetrexed Carcinoma Non-Small-Cell Lung Boehringer Ingelheim October 2006 Phase 1
NCT00701766 Completed Drug: BI 2536 Leukemia Myeloid Acute Boehringer Ingelheim October 2006 Phase 2
NCT00706498 Completed Drug: BI 2536 Prostatic Neoplasms Boehringer Ingelheim September 2006 Phase 2
NCT00376623 Completed Drug: BI 2536 Carcinoma Non-Small-Cell Lung Boehringer Ingelheim July 2006 Phase 2
NCT02211872 Completed Drug: BI 2536 BS intravenous Neoplasms Boehringer Ingelheim August 2004 Phase 1

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?

  • 回答:

    For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

PLK Signaling Pathway Map

PLK Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID