BI 2536

For research use only. Not for use in humans.

目录号:S1109

BI 2536 Chemical Structure

CAS No. 755038-02-9

BI-2536是一种有效的Plk1抑制剂,无细胞试验中IC50为0.83 nM。BI-2536可抑制 Bromodomain 4 (BRD4) ,其Kd值为37 nM,并有效地抑制 c-Myc 的表达。BI-2536可诱导凋亡而减弱自噬。Phase 2。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1978.87 现货
RMB 981.57 现货
RMB 1704.35 现货
RMB 5492.59 现货
RMB 8160.83 现货
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客户使用Selleck生产的BI 2536发表文献168篇:

产品安全说明书

PLK抑制剂选择性比较

生物活性

产品描述 BI-2536是一种有效的Plk1抑制剂,无细胞试验中IC50为0.83 nM。BI-2536可抑制 Bromodomain 4 (BRD4) ,其Kd值为37 nM,并有效地抑制 c-Myc 的表达。BI-2536可诱导凋亡而减弱自噬。Phase 2。
特性 BI 2536是第一个有效的Plk1选择性抑制剂,抑制 Plk1的标记。
靶点
c-Myc [3]
()
PLK1 [1]
(Cell-free assay)
PLK2 [1]
(Cell-free assay)
PLK3 [1]
(Cell-free assay)
BRD4 [3]
(Cell-free assay)
0.83 nM 3.5 nM 9.0 nM 37 nM(Kd)
体外研究

除了Plk1, BI 2536也抑制 Plk2 和Plk3活性,只是抑制程度低点,IC50分别为3.5 nM和9.0 nM。BI 2536比一组63种其他蛋白激酶(IC50>10 μM)选择性高1000多倍。BI 2536 按10 nM 到 100 nM剂量作用于HeLa细胞,抑制有丝分裂中心体中γ-微管蛋白招募和Apc6 磷酸化,抑制染色体臂中释放黏结蛋白, 诱导产生单极主轴,及一些依赖Plk1的其他有丝分裂过程。与作用于Plk1 RNAi效果相一致, BI 2536处理HeLa细胞,使细胞周期停在G2/M期, 随后DNA分解及凋亡,且累积断裂的PARP p85片段,这种作用存在浓度依赖性。BI 2536抑制一组32种人肿瘤细胞系生长,EC50为2-25 nM,抑制指数生长的hTERT-RPE1,人脐静脉内皮细胞 (HUVECs),和正常大鼠肾脏(NRK) 细胞的增殖,EC50为12-31 nM。[1] BI 2536 抑制Plk1,降低甲状腺未分化癌(ATC)细胞如 CAL62, OCUT-1, SW1736, 8505C,和 ACT-1 的生长的生长和活力,EC50为1.4-5.6 nM。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PSN1 NUS4SYNmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfuTWM2OD1yLkCwO|c3KM7:TR?= Mo\yV2FPT0WU
ACN Mnj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTBwMEC4OFMh|ryP NVnlWmpzW0GQR1XS
TE-8 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;ITGlEPTB;MD6wNFk1OSEQvF2= MX;TRW5ITVJ?
LC-2-ad MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrERVZnUUN3ME2wMlAyODl|IN88US=> NYnmd3FlW0GQR1XS
ALL-PO MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTBwMEGzJO69VQ>? NF3kdGxUSU6JRWK=
EW-16 M{LNcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HFdGlEPTB;MD6wNVM{PiEQvF2= M1L0OHNCVkeHUh?=
KM12 M{DOO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTBwMEGzOFgh|ryP MkDjV2FPT0WU
GI-1 NWjaVlRtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTBwMEGzPFMh|ryP NG\wNoJUSU6JRWK=
LS-411N MorIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTBwMEG0NFch|ryP M2fFS3NCVkeHUh?=
ES8 M1LuNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXu2[oh4UUN3ME2wMlAyPDl2IN88US=> MnyzV2FPT0WU
SNU-C2B NYDsO2NFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXiO|M3UUN3ME2wMlAyPTJ4IN88US=> NGfrWYpUSU6JRWK=
CESS MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkGzTWM2OD1yLkCxOlAzKM7:TR?= M3fq[XNCVkeHUh?=
697 Mn6wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;YU|JLUUN3ME2wMlAyPjZ6IN88US=> MYXTRW5ITVJ?
NCI-H1963 NWrJOJFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHxTXpKSzVyPUCuNFE3PzNizszN NYXJcZRbW0GQR1XS
IA-LM M4q1Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoL1TWM2OD1yLkCxOlg5KM7:TR?= Mo\VV2FPT0WU
SW954 NFv5XmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjrVolRUUN3ME2wMlAyPzB3IN88US=> NEju[mFUSU6JRWK=
RL95-2 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\zOG1KSzVyPUCuNFE4OzhizszN MYLTRW5ITVJ?
LXF-289 MnLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIS2cmdKSzVyPUCuNFE4PyEQvF2= MnjnV2FPT0WU
OCUB-M NF;he5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTVTWM2OD1yLkCxPFI3KM7:TR?= NEfiR4xUSU6JRWK=
RKO M2TXPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjDPFd{UUN3ME2wMlAyQTh5IN88US=> MX3TRW5ITVJ?
LOUCY NHXZcIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;6[WFpUUN3ME2wMlAzODVizszN M4LicnNCVkeHUh?=
NOS-1 M3T3Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\DNmlEUUN3ME2wMlAzODl|IN88US=> NInXNGJUSU6JRWK=
A4-Fuk Mn3JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTBwMEKyNVgh|ryP NFzZVopUSU6JRWK=
A388 M3e4Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4roRmlEPTB;MD6wNlIzPyEQvF2= NWrRNI5MW0GQR1XS
TE-9 NYPJZ4s3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVm2S3FXUUN3ME2wMlAzOjZzIN88US=> MWPTRW5ITVJ?
KURAMOCHI MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXmTWM2OD1yLkCyNlg2KM7:TR?= MX\TRW5ITVJ?
KALS-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPoV|R{UUN3ME2wMlAzOzN6IN88US=> NX3SUFhmW0GQR1XS
HOP-62 NEDnSo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvaTWM2OD1yLkCyOFIh|ryP MY\TRW5ITVJ?
RPMI-8402 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXUZYFKSzVyPUCuNFI2ODhizszN MUHTRW5ITVJ?
TE-1 NFP5PFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XwcGlEPTB;MD6wNlUyOiEQvF2= MkDCV2FPT0WU
CCRF-CEM MmD6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXCTIxKSzVyPUCuNFI2PDNizszN NGnOSo9USU6JRWK=
HUTU-80 M3\FfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEe3ZYRKSzVyPUCuNFI3OjRizszN M{\MVnNCVkeHUh?=
NCI-H1648 MoHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTBwMEK2OFch|ryP NWi4Z|RbW0GQR1XS
HCE-4 Ml3GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fncWlEPTB;MD6wNlY5OiEQvF2= MVXTRW5ITVJ?
ETK-1 MlnjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwMEK3N|Yh|ryP MnLXV2FPT0WU
TE-15 MlHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTBwMEK3N|gh|ryP MoT1V2FPT0WU
BE-13 NW\pN3l3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILabWRKSzVyPUCuNFI4PCEQvF2= MknMV2FPT0WU
KE-37 M{Tn[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYO0PFdMUUN3ME2wMlAzPzRzIN88US=> NYTaNplRW0GQR1XS
NCI-H1355 NFmzXZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV31NpExUUN3ME2wMlAzPzh|IN88US=> M1GwOXNCVkeHUh?=
TE-11 MlrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3rTWM2OD1yLkCyPFA6KM7:TR?= MnjyV2FPT0WU
BL-70 NHfJO5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYG5UlZOUUN3ME2wMlAzQDV5IN88US=> M1;hNXNCVkeHUh?=
ES6 M4DpR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTnTWM2OD1yLkCyPFgyKM7:TR?= MnXlV2FPT0WU
GT3TKB MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvKTWM2OD1yLkCyPVU{KM7:TR?= MVLTRW5ITVJ?
LB647-SCLC MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{THN2lEPTB;MD6wN|E6PSEQvF2= NYnicnJQW0GQR1XS
NB13 M2KzV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXy5Z4pCUUN3ME2wMlA{OzF4IN88US=> MkfZV2FPT0WU
ST486 NHLpbWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HXOmlEPTB;MD6wN|M{PyEQvF2= M2fWR3NCVkeHUh?=
NCI-H82 NHjPZ|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTBwMEOzOFMh|ryP NGXvVlBUSU6JRWK=
NTERA-S-cl-D1 NEW3ZW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHxOXZKSzVyPUCuNFM{QTlizszN M1LIRXNCVkeHUh?=
ES4 MnzQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\rTWM2OD1yLkCzOFY{KM7:TR?= NXnlfZVjW0GQR1XS
SK-NEP-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEe1XoVKSzVyPUCuNFM1QTlizszN NIfzc4lUSU6JRWK=
Becker M{[5dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVL0bIxDUUN3ME2wMlA{PTV3IN88US=> NF\tclZUSU6JRWK=
A101D NXO2em9qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TiUWlEPTB;MD6wN|c1QCEQvF2= MmWzV2FPT0WU
SK-UT-1 NWDScItMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXvTWM2OD1yLkCzO|c1KM7:TR?= NXnkUYx5W0GQR1XS
SW982 NH25cI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHUTWM2OD1yLkCzO|kh|ryP M3PvN3NCVkeHUh?=
TE-10 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXLTWM2OD1yLkC0NFQ3KM7:TR?= NYDCS|ZUW0GQR1XS
OVCAR-4 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\lcoNKSzVyPUCuNFQxPTlizszN MoC2V2FPT0WU
KP-N-YS NYS5VmJMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPuOZFKSzVyPUCuNFQxQDVizszN NYLMeFNnW0GQR1XS
BL-41 M1Hzemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnM[lFKSzVyPUCuNFQyOjVizszN NGOyN2tUSU6JRWK=
MZ1-PC NF7tVXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TLemlEPTB;MD6wOFEzPyEQvF2= M1;EdHNCVkeHUh?=
PF-382 NEnVNYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTBwMESxPVgh|ryP MWjTRW5ITVJ?
MOLT-13 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXNVoNKSzVyPUCuNFQzOzhizszN Mkn0V2FPT0WU
HCC1599 M1;rZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI[1eXVKSzVyPUCuNFQzPThizszN MXHTRW5ITVJ?
IST-MEL1 NG\kS3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjZeHZKSzVyPUCuNFQ1PDJizszN MnSyV2FPT0WU
LU-139 M1TGVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVH0R|Q5UUN3ME2wMlA1PDR{IN88US=> NGHLUZdUSU6JRWK=
MS-1 NFK4XWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jE[GlEPTB;MD6wOFcxOSEQvF2= MXXTRW5ITVJ?
MFH-ino MonSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTBwMEWwNFMh|ryP MYPTRW5ITVJ?
IMR-5 MnPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1X6W2lEPTB;MD6wOVAzOSEQvF2= MojTV2FPT0WU
TE-5 NV;YS2xRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;yTWM2OD1yLkC1NFY{KM7:TR?= NX\qRYJTW0GQR1XS
DJM-1 MmjIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvIVW1KSzVyPUCuNFUyPDJizszN Mn7LV2FPT0WU
NB17 M3XaUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nCfWlEPTB;MD6wOVIxPyEQvF2= M1y4U3NCVkeHUh?=
KARPAS-45 M3;RU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2G4fmlEPTB;MD6wOVM2QCEQvF2= MYnTRW5ITVJ?
TGBC1TKB NX3w[mV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2G4XmlEPTB;MD6wOVQxPSEQvF2= MoXkV2FPT0WU
ML-2 NXPoO4MzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHt[4VKSzVyPUCuNFU1OTRizszN Mlm2V2FPT0WU
no-10 M{DHV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLETWM2OD1yLkC1OFc1KM7:TR?= MWDTRW5ITVJ?
CTV-1 NIDFN5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTBwMEW1NFIh|ryP M1;tcnNCVkeHUh?=
SJSA-1 M3X3U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMEW1NkDPxE1? NIXtR|RUSU6JRWK=
HC-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrDW5pKSzVyPUCuNFU2QTdizszN M{[z[3NCVkeHUh?=
TE-12 NHPjXnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlm5TWM2OD1yLkC1OlE{KM7:TR?= NFHze4VUSU6JRWK=
KY821 MnK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDqeY1PUUN3ME2wMlA2PjN{IN88US=> MnyyV2FPT0WU
TALL-1 NVHHPXBHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXrTWM2OD1yLkC1O|A5KM7:TR?= NGjPO2hUSU6JRWK=
DEL MoOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rDdmlEPTB;MD6wOVcxQSEQvF2= Mm\kV2FPT0WU
TE-6 NIGzc|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jGdWlEPTB;MD6wOVczOiEQvF2= MnjzV2FPT0WU
SK-LMS-1 NITndm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXtTWM2OD1yLkC1PFA2KM7:TR?= NUn3ZYY5W0GQR1XS
EW-1 M2DpSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwMEW4N|ch|ryP NV7DcVF6W0GQR1XS
8-MG-BA NGfqXXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTBwMEW4OVEh|ryP MUXTRW5ITVJ?
NALM-6 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\WTWM2OD1yLkC1PVc{KM7:TR?= MULTRW5ITVJ?
LB771-HNC MkfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvvNIZKSzVyPUCuNFU6PzlizszN M3vWUXNCVkeHUh?=
HT-144 NIS4WmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfUTWM2OD1yLkC2NVMh|ryP NXjPSlR2W0GQR1XS
KM-H2 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjVTWM2OD1yLkC2NlIyKM7:TR?= MV\TRW5ITVJ?
SF268 M13H[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{Dj[GlEPTB;MD6wOlI5PiEQvF2= NVG5NJVRW0GQR1XS
RS4-11 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn24TWM2OD1yLkC2N|A1KM7:TR?= Moi4V2FPT0WU
MHH-PREB-1 NF;1cZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfQ[FVRUUN3ME2wMlA3OzF7IN88US=> MUXTRW5ITVJ?
ATN-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzHSotxUUN3ME2wMlA3OzR3IN88US=> MXPTRW5ITVJ?
BB30-HNC M{HRemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\DWpdKSzVyPUCuNFY1OzZizszN MYfTRW5ITVJ?
CPC-N NIHMe3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEiyXFRKSzVyPUCuNFY2OjRizszN MojpV2FPT0WU
NB1 MkTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPxT5RKSzVyPUCuNFY3OTNizszN NET2e4dUSU6JRWK=
KS-1 M4HD[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzkTWM2OD1yLkC2O|Q5KM7:TR?= Mke3V2FPT0WU
RXF393 NWrwPIVHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwME[3OlQh|ryP M2fMXHNCVkeHUh?=
IST-SL2 NXL6XI5PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXOTWM2OD1yLkC3NFA1KM7:TR?= M4jYZnNCVkeHUh?=
GI-ME-N NWjyTlcyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLlS5o2UUN3ME2wMlA4Ojh4IN88US=> MWjTRW5ITVJ?
VA-ES-BJ MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfwPI9KSzVyPUCuNFc1PzVizszN MljRV2FPT0WU
NCI-H1581 NH\rb4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXOeXdKSzVyPUCuNFc1PzhizszN M{HuU3NCVkeHUh?=
U-266 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwMEe0PVch|ryP MnzwV2FPT0WU
DMS-114 NXfGd4FuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUeyU3Q2UUN3ME2wMlA4PTJ6IN88US=> MWjTRW5ITVJ?
NCI-H187 M{nrXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUf0RoNNUUN3ME2wMlA4PzJ4IN88US=> MnziV2FPT0WU
SW962 M2n6fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DQcmlEPTB;MD6wO|g{QSEQvF2= M4nsfHNCVkeHUh?=
MONO-MAC-6 Ml[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwMEe5PFYh|ryP NFP3boRUSU6JRWK=
MOLT-16 NGfh[4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXy5XHA5UUN3ME2wMlA5OTJzIN88US=> MWnTRW5ITVJ?
KNS-42 NYmwTJhmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3aZlZVUUN3ME2wMlA5OTZzIN88US=> MkD2V2FPT0WU
CMK M17Xemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3f4WWlEPTB;MD6wPFIzPSEQvF2= NXjJbIdoW0GQR1XS
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Daudi NEHsd5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\KXFBkUUN3ME2wMlA5OjV4IN88US=> NF3EOYxUSU6JRWK=
NCI-H510A NX3vUmdVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfsbYVKSzVyPUCuNFg{OzZizszN MXHTRW5ITVJ?
LB831-BLC Mkm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvsb4xKSzVyPUCuNFg2PjFizszN MUPTRW5ITVJ?
HEL M13Vc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvoVpNWUUN3ME2wMlA5PjZ6IN88US=> NUGzdpBuW0GQR1XS
LU-134-A NYfG[|VLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17xVWlEPTB;MD6wPFcxQCEQvF2= NH;WWG5USU6JRWK=
NCI-H1694 NED0U5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmW3TWM2OD1yLkC4O|Q1KM7:TR?= MXfTRW5ITVJ?
KGN M1fQWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTBwMEi3OVkh|ryP NGfwfXJUSU6JRWK=
A253 NXzyNIZUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTBwMEi4NlIh|ryP MVXTRW5ITVJ?
DG-75 M3i2U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTpTWM2OD1yLkC4PVIzKM7:TR?= MYLTRW5ITVJ?
MOLT-4 M3fxTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfNTWM2OD1yLkC4PVg{KM7:TR?= MkHxV2FPT0WU
NCI-SNU-5 NXLPcFVQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjBTWM2OD1yLkC5NlU5KM7:TR?= MYPTRW5ITVJ?
ONS-76 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHBTWM2OD1yLkC5Nlc3KM7:TR?= NEDMUIdUSU6JRWK=
NCI-H446 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3v1SWlEPTB;MD6wPVQ3OiEQvF2= M1TKcnNCVkeHUh?=
COR-L279 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvwTWM2OD1yLkC5OVU3KM7:TR?= M3uzNHNCVkeHUh?=
Calu-6 MlzyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTMdYFZUUN3ME2wMlA6PTl6IN88US=> MVHTRW5ITVJ?
BC-3 NGHkV3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{C2e2lEPTB;MD6wPVY3OiEQvF2= NEHBZmZUSU6JRWK=
NCI-H2126 M332WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXH3dItrUUN3ME2wMlA6PzlzIN88US=> NXfDfJJrW0GQR1XS
NCI-H1882 M{XzWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXJUpliUUN3ME2wMlA6QDB7IN88US=> NUHXOYdjW0GQR1XS
BB65-RCC M3zmV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTBwMUCyPVQh|ryP NVjWZ|VlW0GQR1XS
DU-4475 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPNOYZKSzVyPUCuNVA1ODdizszN NHLneoZUSU6JRWK=
NCI-H526 NIP4dZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPodpVKSzVyPUCuNVA1PCEQvF2= NYWx[VNTW0GQR1XS
NEC8 NEDC[JBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HpSmlEPTB;MD6xNFUzPSEQvF2= NWO5TmNGW0GQR1XS
NCI-H1304 MlHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHMSZR{UUN3ME2wMlExPTl2IN88US=> M{PJS3NCVkeHUh?=
L-540 MoH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHkUHJKSzVyPUCuNVA4ODhizszN MWnTRW5ITVJ?
NCI-SNU-16 NEj4[ItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTBwMUC3OFIh|ryP MVnTRW5ITVJ?
HD-MY-Z M2faWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwMUC4OVYh|ryP NWj1fJZpW0GQR1XS
K-562 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTsb|NKSzVyPUCuNVA5PThizszN NGXETlhUSU6JRWK=
JAR MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwMUC5NlUh|ryP NHzv[llUSU6JRWK=
MZ2-MEL NWi3TGdrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXNTWM2OD1yLkGxNFUh|ryP Ml6zV2FPT0WU
L-363 NIPURmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnoTWM2OD1yLkGxNFc6KM7:TR?= NHvZUWxUSU6JRWK=
BV-173 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwMUGyOFMh|ryP M{PzUHNCVkeHUh?=
NCI-H524 MnKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDhOZpvUUN3ME2wMlEyOjd2IN88US=> NI[zOGNUSU6JRWK=
EoL-1-cell NVvQSWpjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHNTWM2OD1yLkGxOlczKM7:TR?= NHvvXlZUSU6JRWK=
K052 NULCdGp6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHBNpRVUUN3ME2wMlEyPzF{IN88US=> MV3TRW5ITVJ?
TK10 MkTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3qTWM2OD1yLkGxO|I5KM7:TR?= M{\KNXNCVkeHUh?=
KU812 NEHmd4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo[yTWM2OD1yLkGyNFQ1KM7:TR?= M4TWRXNCVkeHUh?=
RPMI-8226 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTBwMUKwOVIh|ryP M1nE[3NCVkeHUh?=
MZ7-mel Mn7jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwMUKyN|ch|ryP NGTkcHhUSU6JRWK=
SK-PN-DW NX;6U|BCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\Xe4xKSzVyPUCuNVIzQDdizszN MonQV2FPT0WU
SR MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHexdGJKSzVyPUCuNVI1PDFizszN NFrDVolUSU6JRWK=
RPMI-6666 NHzsVmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmn0TWM2OD1yLkGyO|Q{KM7:TR?= NFf1WXFUSU6JRWK=
no-11 NF21VXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHBS4lKSzVyPUCuNVI5PjlizszN M1;Kb3NCVkeHUh?=
EW-3 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTBwMUK4PVMh|ryP M2rVNXNCVkeHUh?=
LAMA-84 NGnnSJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTBwMUOxPFch|ryP NV3RbY1oW0GQR1XS
HT NFXLNohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPV[FdKSzVyPUCuNVM2PzRizszN NVL0e4hWW0GQR1XS
KP-N-RT-BM-1 MmX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXPTWM2OD1yLkGzOlEzKM7:TR?= NF3IZm9USU6JRWK=
NCI-H747 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLNVJZKSzVyPUCuNVM4KM7:TR?= NYTBOGdCW0GQR1XS
NCCIT NX7YfZBsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3i3ZmlEPTB;MD6xN|k{QSEQvF2= MmPQV2FPT0WU
MLMA NF\xeGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrTVJVKSzVyPUCuNVQyPjdizszN NWT6VWZSW0GQR1XS
LP-1 M3jMSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17yUmlEPTB;MD6xOFI1KM7:TR?= MV7TRW5ITVJ?
CAL-148 M2jseWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnu2TWM2OD1yLkG0OFg{KM7:TR?= NEP2eotUSU6JRWK=
GB-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\NUmlEPTB;MD6xOFUzPiEQvF2= NEfve5RUSU6JRWK=
COR-L88 MnW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33TcWlEPTB;MD6xOFgxOiEQvF2= NETzRmlUSU6JRWK=
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NB5 M3LIfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TINWlEPTB;MD6xOVQ3OiEQvF2= NHvSR|NUSU6JRWK=
SH-4 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFuzSGNKSzVyPUCuNVU1PjZizszN MX\TRW5ITVJ?
EM-2 NIDiPIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnMUnBKSzVyPUCuNVU1PjdizszN MojhV2FPT0WU
TGBC24TKB MnWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3q1eWlEPTB;MD6xOVY2QSEQvF2= NH\NUlhUSU6JRWK=
SCLC-21H MmrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV75VHg3UUN3ME2wMlE2PzB{IN88US=> MXvTRW5ITVJ?
COLO-684 NXyzSFFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17hS2lEPTB;MD6xOVczOSEQvF2= Mn7EV2FPT0WU
KINGS-1 Mn:zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwMUW5NUDPxE1? MUfTRW5ITVJ?
LS-123 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYftR2szUUN3ME2wMlE2QTF5IN88US=> NEHGZ3BUSU6JRWK=
MC116 MnX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\HUWlEPTB;MD6xOlE2QCEQvF2= M2XjTXNCVkeHUh?=
SU-DHL-1 NIPSTGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDpUpJEUUN3ME2wMlE3OjB4IN88US=> MoDJV2FPT0WU
NCI-H64 NG\ZWWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTBwMU[zOFch|ryP NH3HbHBUSU6JRWK=
HCE-T NYXO[4N5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\LSmlEPTB;MD6xOlUxPCEQvF2= Mn\LV2FPT0WU
LOXIMVI NGHucFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILwSG5KSzVyPUCuNVY6PDlizszN NEj2PGRUSU6JRWK=
ARH-77 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlftTWM2OD1yLkG3N|c6KM7:TR?= Mm\QV2FPT0WU
DOHH-2 M4C0emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTBwMUe2O|Ih|ryP Ml\vV2FPT0WU
COLO-320-HSR M2TEZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jFRmlEPTB;MD6xPFE2PCEQvF2= NUXa[pFYW0GQR1XS
NB6 NYPmfYlzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwMUi1OlYh|ryP MlvYV2FPT0WU
L-428 M4TrUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3NTWM2OD1yLkG4PFE{KM7:TR?= Moj4V2FPT0WU
SNB75 M{fmc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTBwMUi4NlQh|ryP NV;BZXdJW0GQR1XS
NCI-H2141 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37jS2lEPTB;MD6xPVAyOSEQvF2= NWPYPFBFW0GQR1XS
KARPAS-299 NWHDenVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIX2NG1KSzVyPUCuNVkzPDFizszN MVnTRW5ITVJ?
LC4-1 Ml;mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;XTWM2OD1yLkG5OVAzKM7:TR?= NEPCcXNUSU6JRWK=
UACC-257 M4f5Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTBwMUm5OFch|ryP NGLlU|RUSU6JRWK=
EVSA-T NUDHTWJyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;kdI1KSzVyPUCuNlA{OTJizszN NYfuNJBvW0GQR1XS
JiyoyeP-2003 NWD0OmlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnW[2ZjUUN3ME2wMlIxPDd5IN88US=> MYnTRW5ITVJ?
NCI-H720 NHvkcoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1Lq[WlEPTB;MD6yNFUzPSEQvF2= Ml3KV2FPT0WU
GAK MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nXdWlEPTB;MD6yNVE5QSEQvF2= MYrTRW5ITVJ?
HH M4nPXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\sdmlDUUN3ME2wMlIyPDB3IN88US=> NFvHU2tUSU6JRWK=
NCI-H1436 NFe1dlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13jTWlEPTB;MD6yNVQ3PCEQvF2= NXPGWlEzW0GQR1XS
GR-ST MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLPWGFpUUN3ME2wMlIyPDh6IN88US=> MkLLV2FPT0WU
BC-1 M3nLfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELLd5pKSzVyPUCuNlI3OTZizszN NEnBd5BUSU6JRWK=
SIG-M5 NYLQSY5zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfjTWM2OD1yLkKyO|I4KM7:TR?= M{TiV3NCVkeHUh?=
NCI-H345 NGO2SVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXxepg5UUN3ME2wMlI{QDB3IN88US=> MkH5V2FPT0WU
OPM-2 NV7YOXRDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGC0bWJKSzVyPUCuNlM5QDJizszN NF7jVIRUSU6JRWK=
LB1047-RCC MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnuTWM2OD1yLkK0OFEh|ryP M{PKNHNCVkeHUh?=
CTB-1 NUTtRYt{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTPc5FKSzVyPUCuNlQ1QTNizszN NFjkSndUSU6JRWK=
A3-KAW M1XWdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\CTWM2OD1yLkK1N|QyKM7:TR?= MUXTRW5ITVJ?
SF126 NEjOPGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XyfWlEPTB;MD6yOVM5OyEQvF2= NVvPNGNSW0GQR1XS
KARPAS-422 MoS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjoWmZKSzVyPUCuNlU1OzVizszN MmTEV2FPT0WU
MEG-01 M{\2UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjTcnlKSzVyPUCuNlU3PzNizszN NF;mWlhUSU6JRWK=
NCI-H209 M{\F[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTYbo1wUUN3ME2wMlI3Ozd2IN88US=> M1\MZ3NCVkeHUh?=
SBC-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwMk[1JO69VQ>? NGHxZ4lUSU6JRWK=
K5 NIrtS5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHl[GpSUUN3ME2wMlI3QTh2IN88US=> MULTRW5ITVJ?
QIMR-WIL MnHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17hcmlEPTB;MD6yO|E2PSEQvF2= MmXUV2FPT0WU
NMC-G1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTBwMkiyNVch|ryP M4qyU3NCVkeHUh?=
IST-MES1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTBwMkmyN|gh|ryP M1H5XXNCVkeHUh?=
SW684 NWrlTphNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rEWWlEPTB;MD6zNFA1PyEQvF2= MoLCV2FPT0WU
MV-4-11 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;w[WlEPTB;MD6zNFc5QCEQvF2= NEL4XIxUSU6JRWK=
LAN-6 M3nGO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDKTWM2OD1yLkOxOVczKM7:TR?= NWLQdmtKW0GQR1XS
RH-1 NGLkb4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jDb2lEPTB;MD6zNVg4OSEQvF2= NX3XcoExW0GQR1XS
CP66-MEL M2PCSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7XSGcyUUN3ME2wMlMyQDd6IN88US=> NEHDUIZUSU6JRWK=
EC-GI-10 M{e3c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIn3ToJKSzVyPUCuN|I6QDdizszN M130fnNCVkeHUh?=
GDM-1 NW\USYlnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LhW2lEPTB;MD6zN|A2QSEQvF2= Ml7FV2FPT0WU
IST-SL1 NWLkXpN5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTBwM{S5NVQh|ryP NX;KT4R[W0GQR1XS
KMOE-2 NGqzSZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH34NnFKSzVyPUCuN|UyPzVizszN NFyxZ49USU6JRWK=
OS-RC-2 MnTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;qTWM2OD1yLkO1OVQ1KM7:TR?= MkXWV2FPT0WU
HDLM-2 Mm\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmG0TWM2OD1yLkO3PFE1KM7:TR?= MljNV2FPT0WU
DSH1 MkG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXw[IJYUUN3ME2wMlM5PjNzIN88US=> NF7xVGxUSU6JRWK=
LS-1034 NGXsZoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\RTWM2OD1yLkO4PVU1KM7:TR?= NYDOV2RiW0GQR1XS
LB373-MEL-D MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\XbJl4UUN3ME2wMlM6OTl5IN88US=> MY\TRW5ITVJ?
GOTO MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjUTWM2OD1yLkSyNVE5KM7:TR?= M2\Hd3NCVkeHUh?=
MRK-nu-1 NXPuU4h2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorDTWM2OD1yLkSyNlA2KM7:TR?= MW\TRW5ITVJ?
SK-MM-2 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnsTWM2OD1yLkSzOFQzKM7:TR?= NGXuXmVUSU6JRWK=
BOKU MlXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jkeWlEPTB;MD60N|c6OiEQvF2= MYHTRW5ITVJ?
NOMO-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjkSnBKSzVyPUCuOFM5PiEQvF2= NVHxXmpbW0GQR1XS
J-RT3-T3-5 M3jRfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7zW3hMUUN3ME2wMlQ1QDd6IN88US=> NVnsXGk5W0GQR1XS
COLO-668 NYDZTY1DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXQeoNIUUN3ME2wMlQ2PjZ6IN88US=> MVLTRW5ITVJ?
SF539 NGPiWFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTBwNEi2PFQh|ryP MWnTRW5ITVJ?
LB2518-MEL M2i0VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PofGlEPTB;MD60PVcxOyEQvF2= NGLzSGZUSU6JRWK=
TE-441-T MlfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3E[2VKSzVyPUCuOVAyOiEQvF2= NFX4UJVUSU6JRWK=
MDA-MB-134-VI MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrYTWM2OD1yLkWwPVIyKM7:TR?= MXPTRW5ITVJ?
SCC-3 NYD5fIx{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jVTGlEPTB;MD61NVg4OyEQvF2= MlPJV2FPT0WU
KLE NEPhSHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITVe5NKSzVyPUCuOVIyPzFizszN NGL5OpFUSU6JRWK=
LB2241-RCC NHrxV3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHvV3VzUUN3ME2wMlUzPTJ3IN88US=> NVzsPXdsW0GQR1XS
NCI-H1417 Mn:2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDPcFlKSzVyPUCuOVM1OzVizszN NEC3XIFUSU6JRWK=
NCI-H2081 NInscG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrxcY1KSzVyPUCuOVg3OTFizszN M2ezNHNCVkeHUh?=
NCI-H1522 MorRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37XVWlEPTB;MD61PVM5OyEQvF2= MWrTRW5ITVJ?
NCI-H889 NGDoeIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwNUm4OFQh|ryP NFuwWpRUSU6JRWK=
CGTH-W-1 M2rRe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPuTWM2OD1yLk[wO|U2KM7:TR?= M{XPZ3NCVkeHUh?=
EB-3 Mmn5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LWTWlEPTB;MD62NVE2OyEQvF2= MmO5V2FPT0WU
D-336MG Mk\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTBwNkG3PVEh|ryP NWS2OWY5W0GQR1XS
LC-1F NI\4[FRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnR[JNKSzVyPUCuOlI2QTJizszN MVfTRW5ITVJ?
MHH-NB-11 NGr5[3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHqTWM2OD1yLk[zPFAyKM7:TR?= M4rUZnNCVkeHUh?=
SK-N-FI NHvjSpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PKVGlEPTB;MD62N|kyKM7:TR?= MY\TRW5ITVJ?
NCI-H69 M{HCUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDNTWM2OD1yLk[0PFc6KM7:TR?= NU\JcG86W0GQR1XS
SCH NGC1coNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDsN|VKSzVyPUCuOlYxOjNizszN M4nUNHNCVkeHUh?=
LS-513 M2Pidmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzVfXlKSzVyPUCuOlczPTlizszN M{jQWnNCVkeHUh?=
CP67-MEL Ml\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTaTWM2OD1yLk[3OVk3KM7:TR?= MVXTRW5ITVJ?
GCIY NHHPNpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HkO2lEPTB;MD63NFM3OyEQvF2= MWfTRW5ITVJ?
SHP-77 NUfNemFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrrfnlQUUN3ME2wMlcxPzN2IN88US=> NWXNWJB[W0GQR1XS
EHEB MlTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTBwN{G4OVQh|ryP NHPFTXJUSU6JRWK=
D-247MG MnnTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3vXGNNUUN3ME2wMlc{OjN{IN88US=> MmryV2FPT0WU
Raji M3PHdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwN{S5PFkh|ryP NGHObYJUSU6JRWK=
MPP-89 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3S4dGlEPTB;MD63OVk4QCEQvF2= MmKyV2FPT0WU
EKVX MkTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXmOG9KSzVyPUCuO|kxPzNizszN NXHqUIluW0GQR1XS
HCC2218 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkn3TWM2OD1yLke5NVMyKM7:TR?= MXTTRW5ITVJ?
KNS-81-FD MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;YUWlEPTB;MD64NVAyOSEQvF2= NVTRSo06W0GQR1XS
HCC2157 MmTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwOES5OVEh|ryP MmnVV2FPT0WU
BT-474 M{DocGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfCS5N3UUN3ME2wMlg5QDV2IN88US=> MnvBV2FPT0WU
NCI-H748 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rMTmlEPTB;MD65NVIh|ryP M4HneXNCVkeHUh?=
EW-24 NHHWVoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwOUKwNFIh|ryP MYrTRW5ITVJ?
D-263MG M37MUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPpN4dvUUN3ME2wMlk1PTF{IN88US=> NFnK[GRUSU6JRWK=
OMC-1 M1juSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7xRVVEUUN3ME2wMlk3Ozd|IN88US=> Mn7rV2FPT0WU
NCI-H2196 NIX1d4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTBwOUe3O|ch|ryP NYnSNG5uW0GQR1XS
HAL-01 NHHjN|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M124PWlEPTB;MD65PVg4OiEQvF2= NX;p[WhIW0GQR1XS
NCI-H2107 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PM[mlEPTB;MT6wNVg2PCEQvF2= NHLSSY1USU6JRWK=
LB996-RCC MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPOZoRqUUN3ME2xMlA5ODVzIN88US=> MmfJV2FPT0WU
NCI-H1395 NYSxbVZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTFwMUC2O{DPxE1? M{DjTXNCVkeHUh?=
CHP-126 NXr4[mVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\reHFOUUN3ME2xMlE3OTl7IN88US=> MUnTRW5ITVJ?
NB69 MmPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoGxTWM2OD1zLkK2NVQ5KM7:TR?= M2TPSnNCVkeHUh?=
CAS-1 MoruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTFwM{SyN|Eh|ryP MkDvV2FPT0WU
JVM-3 M3;3TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zyPGlEPTB;MT60O|g2PSEQvF2= NFXC[INUSU6JRWK=
DMS-153 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfNe29mUUN3ME2xMlU4Pjd2IN88US=> NV7PdnZSW0GQR1XS
SK-MEL-2 NVHLVm5oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;WRWlEPTB;MT63NVc5QSEQvF2= NUXiUndoW0GQR1XS
NCI-H1155 MmDSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTFwN{O2O|Yh|ryP MlnUV2FPT0WU
NCI-H1092 MlfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTFwN{[xPFIh|ryP M4PlN3NCVkeHUh?=
LU-165 NVTYbZM{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjNTolKSzVyPUGuPFY1PzZizszN MmCyV2FPT0WU
HL-60 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHju[WVKSzVyPUGuPVk6ODhizszN MWrTRW5ITVJ?
REH M{XiPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTJwMEC1PFIh|ryP MmfoV2FPT0WU
JVM-2 M2XYbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIqxTYJKSzVyPUKuNFYyOzVizszN MX\TRW5ITVJ?
MN-60 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTJwMUezNFgh|ryP NEPR[JhUSU6JRWK=
SCC-15 NFnEdodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHSNmQ6UUN3ME2yMlIxOjdizszN M3jCWXNCVkeHUh?=
SNU-C1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzYUo5UUUN3ME2yMlIyOzR|IN88US=> MX;TRW5ITVJ?
SK-MEL-1 M3vSO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHryRYhKSzVyPUKuN|IxPDdizszN NXy2fVVSW0GQR1XS
TGW M17RVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULhbG44UUN3ME2yMlM2ODJ5IN88US=> NIXJPFdUSU6JRWK=
CA46 M3HhcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37GZ2lEPTB;Mj63OVk3PyEQvF2= NXjzTWM6W0GQR1XS
NCI-H23 MoL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTJwOEC3PVEh|ryP NGnObJlUSU6JRWK=
MMAC-SF M17Jfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\pdVZFUUN3ME2yMlg3PjJ6IN88US=> M1HBNHNCVkeHUh?=
NCI-H2171 M2\SW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTsWWlKSzVyPUOuNFM1PDhizszN Mlz1V2FPT0WU
A704 M4f5PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTNwMUSxPVQh|ryP MWTTRW5ITVJ?
DB NUfqR3p7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\6[GJKSzVyPUOuNlU2PzZizszN NG[4RVZUSU6JRWK=
NCI-H719 NHPWW4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTNwM{CzPFQh|ryP NX3GfolKW0GQR1XS
MC-CAR M1i3Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnIZ4x3UUN3ME2zMlU1QDF5IN88US=> NEHSVmNUSU6JRWK=
SIMA M1TGeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3n1[WlEPTB;Mz61PFQyPiEQvF2= NWjiOG1TW0GQR1XS
SW872 NVHpbZNbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLxR5ZKSzVyPUOuO|gyODFizszN MoSwV2FPT0WU
HCC1187 M1PBSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3V[3c1UUN3ME2zMlc5OzF3IN88US=> NXnnbHNEW0GQR1XS
EW-13 NGP1UWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXr4SW1wUUN3ME2zMlg{PDF5IN88US=> MUXTRW5ITVJ?
NCI-SNU-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TjfGlEPTB;ND6yNVk6QSEQvF2= MV\TRW5ITVJ?
NCI-H226 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3:yc2lEPTB;ND6zN|YxPiEQvF2= MVfTRW5ITVJ?
RPMI-8866 NX3MRVBxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljmTWM2OD12LkO2NFI6KM7:TR?= MlGwV2FPT0WU
OCI-AML2 NFjEdpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rYNGlEPTB;ND61OVI{KM7:TR?= MlzhV2FPT0WU
LU-65 M1LFW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXH5cppuUUN3ME20Mlk{ODN|IN88US=> MmS4V2FPT0WU
SK-N-DZ NIr1TFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;GZ4pKSzVyPUWuOlM1PjVizszN NFrncllUSU6JRWK=
NB14 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTVwOUexN|Uh|ryP NWTubWxRW0GQR1XS
COLO-829 NV[5eJJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmezTWM2OD14LkOzN|U6KM7:TR?= MVzTRW5ITVJ?
MHH-CALL-2 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTZwNUG1NFgh|ryP MnPpV2FPT0WU
NCI-H1770 M3nYcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\oVIk3UUN3ME22MlY3QTB2IN88US=> Moi4V2FPT0WU
ECC4 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTZwOEKxO|kh|ryP MkPhV2FPT0WU
A498 NEnZXJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDtfHlbUUN3ME22Mlg4OTl{IN88US=> NUfDWXJ6W0GQR1XS
DMS-79 NV7XbWJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoexTWM2OD15LkC0OVEzKM7:TR?= NF3wTVJUSU6JRWK=
P30-OHK MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnsTWM2OD15LkKxPVA3KM7:TR?= MUjTRW5ITVJ?
D-502MG MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTdwOUizOkDPxE1? M1nSRXNCVkeHUh?=
RCC10RGB MkLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRThwME[yPEDPxE1? MXfTRW5ITVJ?
U-698-M MlzYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nHWmlEPTB;OD6yPVIzPiEQvF2= Mlu4V2FPT0WU
BB49-HNC NF\UVYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmi1TWM2OD17LkSyNlY2KM7:TR?= NGPkT49USU6JRWK=
ES1 NHXacnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTkTWM2OD17Lk[4PVU3KM7:TR?= M2TkUXNCVkeHUh?=
MFM-223 NYW4WmY6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYn6RndZUUN3ME2xNE46QTJ5IN88US=> NH;NZWtUSU6JRWK=
C2BBe1 M2i0WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlH1TWM2OD1zMT6zOVI{KM7:TR?= NVvKSm42W0GQR1XS
EB2 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjxWGVmUUN3ME2xNk43QDhzIN88US=> M4T1VHNCVkeHUh?=
C8166 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrpTWM2OD1zMz64N|A{KM7:TR?= NFHZ[2VUSU6JRWK=
ES3 M33FeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTF|Lkm5O|ch|ryP NVH3SmplW0GQR1XS
NCI-H1650 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTF4LkO3OlUh|ryP MUXTRW5ITVJ?
Mo-T MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTF5LkSwNlkh|ryP MV;TRW5ITVJ?
NB7 NUDnUGdHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLkTWM2OD1zNz63OFY4KM7:TR?= MnvEV2FPT0WU
ES7 M1\KdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPydHlKSzVyPUG5MlU2ODdizszN M{\ucHNCVkeHUh?=
ES5 MlnJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2S0UmlEPTB;MkGuO|Y4OSEQvF2= M3nnb3NCVkeHUh?=
MSTO-211H NIC3dI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTJzLki4OVgh|ryP NXTlO|dEW0GQR1XS
U-87-MG NE\kPZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3EcpNKSzVyPUK1MlE6PjZizszN NVvvOVFoW0GQR1XS
THP-1 NXjtfGY4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnO1TWM2OD1{OT63NlAyKM7:TR?= NIH3PWVUSU6JRWK=
NB10 NHfKfJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTNyLkK2PVQh|ryP M1i2T3NCVkeHUh?=
NH-12 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTN|LkKwNVch|ryP NV7KflZ7W0GQR1XS
COLO-824 NWLMR|lmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTN2LkGwNFYh|ryP NXvLdmhmW0GQR1XS
SKM-1 M3nO[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;FbFJKSzVyPUO3Mlg1OjJizszN NUnFelIzW0GQR1XS
NCI-H1838 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{j4ZWlEPTB;M{iuN|c6PyEQvF2= M{j5dXNCVkeHUh?=
RL M2TPSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjPOmlyUUN3ME2zPU4zPDd5IN88US=> NHXwNmxUSU6JRWK=
COLO-800 M3;ocGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFmy[FdKSzVyPUSwMlA4PzNizszN NED4XJJUSU6JRWK=
KG-1 NIruOZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TTSmlEPTB;NECuPFk2PSEQvF2= M{PlZnNCVkeHUh?=
TUR NV7Ke5A5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{f6U2lEPTB;NEGuOlM6QSEQvF2= MnLPV2FPT0WU
LNCaP-Clone-FGC MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17aVWlEPTB;NEGuPVAyPyEQvF2= M{GxO3NCVkeHUh?=
NCI-H322M NWjwXWpoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTR{LkW5PFQh|ryP MVnTRW5ITVJ?
LNCaP  MkHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHqOmxmUUN3ME25NU4{KG6P NWT6bmFxOjV3MEWxO|Q>
C4-2 NITz[GhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1q2eGlEPTB;ODDuUS=> NXfDXJJkOjV3MEWxO|Q>
JURKAT NHHaOFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moj3NlQhcA>? NVuzWFNMUUN3ME20NVYvPjZibl2= M{\ETlI1PTF7OUm1
MOLT-4 MofvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVqyOEBp M1TvNmlEPTB;Mki1N{42KG6P M4K1blI1PTF7OUm1
REH M4rmUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV6yOEBp NIS2[FVKSzVyPUK4O{43QCCwTR?= M{XrW|I1PTF7OUm1
NALM-6 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX2yOEBp NXPyNVlvUUN3ME2zOFM{OCCwTR?= M3jZS|I1PTF7OUm1
RS 4;11 NHLIcWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrOcIQzPCCq NG\XNJBKSzVyPUWxPU4xPSCwTR?= MYOyOFUyQTl7NR?=
697 NUPJO5B6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LPeVI1KGh? M37SNWlEPTB;MkGwO{4yKG6P MkPTNlQ2OTl7OUW=
SIL-ALL NEnINWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;vRokzPCCq MmP5TWM2OD1zOUmuO|chdk1? MmfmNlQ2OTl7OUW=
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P12 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETubJUzPCCq NVLtNVJXUUN3ME2zPU4zPyCwTR?= MnnUNlQ2OTl7OUW=
NALM-16 NEG2ZYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFv3fW0zPCCq MWPJR|UxRTl4LkK4JI5O MmHlNlQ2OTl7OUW=
JURKAT MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\DUVQ5KGh? NH;wWHRKSzVyPUG0Mlg1KG6P MnSyNlQ2OTl7OUW=
MOLT-4 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWC0PEBp MVzJR|UxRTJ4Lk[gcm0> NWHzVW5TOjR3MUm5PVU>
REH NIfvVIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYm0PEBp M1;q[mlEPTB;NESuO|Ehdk1? MmDCNlQ2OTl7OUW=
NALM-6 NVXLfHVST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV60PEBp MmPWTWM2OD1{Mz6yOkBvVQ>? NV\ZeXRCOjR3MUm5PVU>
RS 4;11 NU\vS4lzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjiNmpxPDhiaB?= M3;G[mlEPTB;MU[0MlI5KG6P MnnlNlQ2OTl7OUW=
697 NFvtXG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVi0PEBp NXrjO45FUUN3ME2zNFUvOyCwTR?= NYDxWZRtOjR3MUm5PVU>
SIL-ALL NFSxVndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYi0PEBp MlXMTWM2OD15ND62NkBvVQ>? NVzLcJo6OjR3MUm5PVU>
CEM NH64O49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPFU5E1QCCq NHno[YRKSzVyPUK0MlU2KG6P M2X1ZVI1PTF7OUm1
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NALM-16 NEmzZWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHBemc1QCCq M336TWlEPTB;NkOuNlQhdk1? MmXFNlQ2OTl7OUW=
JURKAT M{\EXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTwW2diPzJiaB?= MV3JR|UxRTNwNkWgcm0> NWfJTZJROjR3MUm5PVU>
MOLT-4 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYe3NkBp MYTJR|UxRTdwM{mgcm0> MmT0NlQ2OTl7OUW=
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NALM-6 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXy3NkBp NUTSTWx{UUN3ME2xMlc5KG6P M4TzOlI1PTF7OUm1
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SIL-ALL M{HEd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HmV|czKGh? NVzTcIhWUUN3ME23MlIhdk1? NYTJc3pwOjR3MUm5PVU>
CEM M1vxXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIf0cHM4OiCq MXvJR|UxRTVwNEKgcm0> NFj3b3AzPDVzOUm5OS=>
P12 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYG3NkBp MWjJR|UxRTZwM{egcm0> MY[yOFUyQTl7NR?=
NALM-16 MoPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWC3NkBp NVnyS5hRUUN3ME23O{44OyCwTR?= M2Gyd|I1PTF7OUm1
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G166 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LxeWlEPTB;Nz6wJI5O MknTNlQzODR5M{O=
CB660 M2r6Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTZwNDDuUS=> NWTrNGVLOjR{MES3N|M>
CB1117 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTF3Lk[gcm0> MWGyOFIxPDd|Mx?=
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OVCAR-8 NFn4W|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYOwcXdEUUN3ME23MlE6KMLzIEOuOlAhdk1? Mmf6NlM6PjJ2NEW=
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LNCaP  NYHjVoFmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTVTlFCTE2VTx?= MkPXTWM2OOLKvEe1JI5O MX[yN|g5PDR{OB?=
PC3 NHrjV4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{OzeWROW09? MoH6TWM2OOLKvEG3OUBvVQ>? MWCyN|g5PDR{OB?=
RT4 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXW0TXpsUUN3ME2yO{4zOSCwTR?= NFLjN|MzOzd7Mk[zPS=>
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T24 NGrhVJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDMTWM2OD15OT6xNkBvVQ>? NEG3e3IzOzd7Mk[zPS=>
MCF7  MlzOSpVv[3Srb36gRZN{[Xl? M2XGWVExOCCwTR?= MX[xJIg> M2XkU2ROW09? M3PP[ZJm\HWlZYOgeIhmKGmwZIXjeIlwdiCxZtMgS5Jm[jFuwrDT[4syNMLiUIOyMOKhW2W{cHnuZVMtKGGwZNMgW4l{eDJ? MmD5NlM4PzB{NES=
KB-V1  MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXKdGQ6UUN3ME2zMlkzKM7:TR?= NFy2OJczOzV7M{G5Oi=>
Hec50co MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo[wTWM2OD13IH7N MUOyN|E1PjZ6Nx?=
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786-O MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHZOU05OCCwTR?= M2PuVlk3KGh? M{nnVmhEdA>? MWrzeZBxemW|c3XzJJRp\SCycn;sbYZmemG2aX;uJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXyJJdqfGhiSVO1NOKhfmGudXXzJI9nKDJidH:gNlAhdk1? NIPtdJozOTZ2MkO3OC=>
A498 MnLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPLOU05OCCwTR?= MYi5OkBp MVXIR4w> MWXzeZBxemW|c3XzJJRp\SCycn;sbYZmemG2aX;uJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXyJJdqfGhiSVO1NOKhfmGudXXzJI9nKDJidH:gNlAhdk1? NUjYOW11OjF4NEKzO|Q>
ACHN Mn;LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nlelUuQDBibl2= NHXTXpY6PiCq NGKzPZdJS2x? NWTybW5Ye3WycILld5NmeyC2aHWgdJJwdGmoZYLheIlwdiCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meiC5aYToJGlEPTEEoI\hcJVmeyCxZjCyJJRwKDJyIH7N MXmyNVY1OjN5NB?=
Caki-1 Ml7OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\OOU05OCCwTR?= MWC5OkBp MU\IR4w> MYTzeZBxemW|c3XzJJRp\SCycn;sbYZmemG2aX;uJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXyJJdqfGhiSVO1NOKhfmGudXXzJI9nKDJidH:gNlAhdk1? NV7PVoloOjF4NEKzO|Q>
SN12C NWPUZY44T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELyfm02NThyIH7N M3z5Vlk3KGh? NHqwcGtJS2x? M3XvT5N2eHC{ZYPz[ZMhfGinIIDyc4xq\mW{YYTpc44hcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZIhf2m2aDDJR|UxyqC4YXz1[ZMhd2ZiMjD0c{AzOCCwTR?= NH;yWYEzOTZ2MkO3OC=>
HMC-1.1 NX;iZnEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULSSndEOS1zMECwJI5O MorlO|IhcA>? MWnpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoU> M4rtdVIyOjR{MUi5
HMC-1.2 NGfhcIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUOxMVExODBibl2= MnLpO|IhcA>? MXvpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoU> MljUNlEzPDJzOEm=
C2 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTwWnEyOS1zMECwJI5O NIjaeVM4OiCq MX;pcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoU> MoGyNlEzPDJzOEm=
CHP-212 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFX2O2EyNTF{NTDuUS=> Mmn5NlQuOTJyIHi= MV7pcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n NGTSVJUzOTF4OUK0Ni=>
IMR-32 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zUdlEuOTJ3IH7N MV2yOE0yOjBiaB?= MoPhbY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= M1;UV|IyOTZ7MkSy
Kelly MlTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILFbocyNTF{NTDuUS=> NVPKXXV5OjRvMUKwJIg> NVvVcnJKcW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBjd3SqIITpcYUuKGGwZDDkc5NmNWSncHXu[IVvfCCvYX7u[S=> NH\DSIkzOTF4OUK0Ni=>
SH-EP NFvBe|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nZZVEuOTJ3IH7N M1PiOVI1NTF{MDDo NWDFXpdocW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBjd3SqIITpcYUuKGGwZDDkc5NmNWSncHXu[IVvfCCvYX7u[S=> M3;RPFIyOTZ7MkSy
SH-SY5Y Mm\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYOxMVEzPSCwTR?= NILaeIwzPC1zMkCgbC=> NVL0VlExcW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBjd3SqIITpcYUuKGGwZDDkc5NmNWSncHXu[IVvfCCvYX7u[S=> MWOyNVE3QTJ2Mh?=
SK-N-AS NWjme21PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HZPFEuOTJ3IH7N M2jjRlI1NTF{MDDo MkO1bY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= NGnuN3EzOTF4OUK0Ni=>
SK-N-BE NYi2cmFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVWxMVEzPSCwTR?= MV[yOE0yOjBiaB?= NG\zeGZqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l Mn3oNlEyPjl{NEK=
KG1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLqNU8yOC9zMECgcm0> MkDGO|IhcA>? MX3EUXNQ M3fhfIlvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZo91cCC2aX3lMUBidmRiZH;z[U1l\XCnbnTlcpQhdWGwbnW= MnXzNVk1PTh|NUi=
U937 NEK5UlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3WNU8yOC9zMECgcm0> M4XPSVczKGh? NWTqcIt5TE2VTx?= Mn25bY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= NYDySpc2OTl2NUizOVg>
CAL62 Moq1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLKSYM{OC5zLUGwNEBvVQ>? NG\5OYw4OiCq NFjWNZpFVVOR NUmwOIdPTUN3ME2xMlQhdk1? M3LQclE6OjJ|NUWz
OCUT-1 MnvBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYmwMlEuOTByIH7N NXf1O5pIPzJiaB?= M4G5V2ROW09? MkSzSWM2OD1{LkOgcm0> NIXhfG4yQTJ{M{W1Ny=>
8505C NIXpO4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1n6RlAvOS1zMECgcm0> MWq3NkBp NXztUJRnTE2VTx?= M2HvdGVEPTB;Mz6yJI5O M3u4NVE6OjJ|NUWz
ACT-1 NFzWfGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPm[ooyOC5zLUGwNEBvVQ>? MVq3NkBp M3e4bGROW09? NIi4NIdGSzVyPUWuOEBvVQ>? M4PIdFE6OjJ|NUWz
SW1736 M1rNNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LBOFAvOS1zMECgcm0> M3zVSFczKGh? M2TiXWROW09? M33qdWVEPTB;NT62JI5O NWW3cm5{OTl{MkO1OVM>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pro-caspase-8 / cleaved caspase-8 / cleaved caspase-3 / cleaved caspase-9; 

PubMed: 27699933     


PLKi‐induced caspase activation. HeLa cells were treated with BI 2536 (10 nmol/L), BI 6727 (68 nmol/L), or GSK461364 (11 nmol/L), and HCT 116 cells were treated with BI 2536 (20 nmol/L), BI 6727 (70 nmol/L), or GSK461364 (12 nmol/L) for 48 h. The levels of cleaved caspase (CASP)‐3, ‐8, and ‐9 were examined by Western blot analysis.

p-HH3 / PARP / Myc / p-Myc; 

PubMed: 24771642     


Western blotting showing more mitotic arrested (shown by phospho-histone H3) and apoptotic (shown by PARP) cells as well as lower MYC levels in LNCaP-Pim1 cells after BI 2536 treatment compared with LNCaP-Neo cells. The difference is obvious at lower dose of BI 2536 (10 nM). Both total MYC expression and phosphor-MYC levels were lower in Pim1 cells than Neo cells after BI 2536 treatment.

pMEK / MEK / pERK / ERK / pRSK1 / RSK1; 

PubMed: 28430578     


(A) and (B) Western blot analysis of the expression and activation of components of the MEK-ERK-RSK1 pathway in MKN45 and MKN74 cancer cells treated with BI 2536 and BI 6727 for 24 and 48 hours, respectively.

pPlk1 / Plk1 / pMyt1; 

PubMed: 28430578     


(A) and (B) Western blot analysis of the expression and phosphorylation of Plk1, and phosphorylation of Myt1 in the CSC-like and cancer cells after treatment with BI 2536 and BI 6727 for 24 and 48 hours, respectively.

Aurora B / pAurora B / pAurora C / pH3 / Cyclin B1 / Securin / pBcl-XL / MPM2; 

PubMed: 25169932     


Western blot analysis of cells treated for 24 h with the indicated inhibitor concentrations. Cell lysates were immunoblotted for Plk1, Phospho-Aurora B (T232)/Aurora C (T198), Aurora B, histone H3 phosphorylated at S10 (pH3), Cdk1, Cyclin B1, Securin, Phospho-Bcl-XL, Induced myeloid leukemia cell differentiation protein Mcl-1, MPM-2 and β-Actin. Left (Hela cells); Right (HUVEC)

27699933 24771642 28430578 25169932
Immunofluorescence
p-H2AX / propidium iodide; 

PubMed: 22309939     


Apoptotic images of the cells after BI 2536 treatment, as revealed by HCS (high-content screening) instrument (×10) with phospho-H2AX antibody or PI (propidium iodide) intake. 

Pericentrin / α-tubulin; 

PubMed: 21772266     


MEFs were labelled using Plk1, pericentrin and α-tubulin antibodies and 4,6-diamidino-2-phenylindole for the analysis by immunofluorescence microscopy. Representative examples of BI 2536-treated and control MEFs are depicted. Scale bar, 5 μm.

22309939 21772266
Growth inhibition assay
Cell viability; 

PubMed: 21772266     


Proliferative activity of MEFs at different BI 2536 concentrations (25–250 nM; means±s.d., n=3, for each concentration). *P<0.05, **P<0.01, ***P<0.001, Student's t-test, unpaired and two-tailed.

21772266
体内研究

BI 2536静脉注射给药多种移植瘤模型,每周一次或两次,效果都很好,通过使细胞周期停滞而抑制细胞增殖,随后诱导肿瘤细胞死亡。BI 2536按 50 mg/kg剂量处理HCT 116移植瘤,每周一次或两次,显著抑制肿瘤生长,T/C 分别为15%和0.3%。BI 2536每周处理两次BxPC-3和A549模型,也显著抑制肿瘤生长,T/C分别为5% 和14%。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

- 合并

体外Plk1激酶实验:

重组人Plk1 (1-603残基) 作为氮端,携带杆状病毒表达系统的GST-标记的融合蛋白通过亲和层析,使用谷胱甘肽-琼脂糖而纯化。在梯度稀释的BI 2536存在时,使用 20 ng 重组激酶,及10 μg牛奶中的酪蛋白作为底物进行Plk1 酶活性实验。在终体积为60 μL 的混合物(15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP)中30oC下进行激酶反应45分钟。加入 125 μL 冰冻的5% TCA终止反应。沉淀物转移到混合酯纤维素的多屏过滤板上,使用1% TCA冲洗实验板,然后利用放射性进行测量。绘制剂量反应曲线,而计算IC50值。
细胞实验:

[1]

- 合并
  • Cell lines: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji, PC-3,等等
  • Concentrations: 溶于DMSO, 终浓度为~1 μM
  • Incubation Time: 24,和72小时
  • Method:

    使用不同浓度BI 2536处理细胞24和72小时。 在荧光分光光度计中测量Alamar Blue染料转换而测定细胞生长。为了测定培养基中DNA含量,细胞悬液在80%乙醇中混合, 使用溶于PBS的0.25% Triton X-100处理5分钟,然后与0.1% RNase 和溶于PBS的 10 μg/mL碘化丙啶在室温下温育20分钟。通过流式细胞仪分析而测定细胞周期谱。


    (Only for Reference)
动物实验:

[1]

- 合并
  • Animal Models: 皮下注射HCT 116, NCI-H460, 或A549 细胞的雌性BomTac:NMRI-Foxn1nu 小鼠
  • Dosages: ~50 mg/kg
  • Administration: 静脉注射,每周一到两次
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 21 mg/mL (40.25 mM)
Water Insoluble
Ethanol '100 mg/mL
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
30% PEG 400+0.5% Tween 80+5% Propylene glycol
15mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 521.66
化学式

C28H39N7O3

CAS号 755038-02-9
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02215044 Terminated Drug: BI 2536 intravenous|Drug: Gemcitabine intravenous Pancreatic Neoplasms Boehringer Ingelheim June 2007 Phase 1
NCT02211833 Completed Drug: BI 2536|Drug: Pemetrexed Carcinoma Non-Small-Cell Lung Boehringer Ingelheim October 2006 Phase 1
NCT00701766 Completed Drug: BI 2536 Leukemia Myeloid Acute Boehringer Ingelheim October 2006 Phase 2
NCT00706498 Completed Drug: BI 2536 Prostatic Neoplasms Boehringer Ingelheim September 2006 Phase 2
NCT00376623 Completed Drug: BI 2536 Carcinoma Non-Small-Cell Lung Boehringer Ingelheim July 2006 Phase 2
NCT02211872 Completed Drug: BI 2536 BS intravenous Neoplasms Boehringer Ingelheim August 2004 Phase 1

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?

  • 回答:

    For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

PLK Signaling Pathway Map

PLK Inhibitors with Unique Features

相关PLK产品

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID