BI 2536

目录号：S1109

BI 2536 Chemical Structure

Molecular Weight(MW): 521.66

BI 2536是一种有效的Plk1抑制剂，无细胞试验中IC50为0.83 nM，比作用于Plk2和Plk3选择性分别高4和11倍。Phase 2。

规格 价格 库存 购买数量  
RMB 1978.87 现货
RMB 981.57 现货
RMB 1704.35 现货
RMB 5492.59 现货
RMB 8160.83 现货
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客户购买Selleck的此次产品后发表的文献55篇：

客户使用该产品的13个实验数据：

  • (C) HeLa cells were treated with inhibitors of Aurora B (hesperadin), Aurora A (Aurora A inhibitor I), CDK1 (roscovitine), or PLK1 (BI2536) for 2 hours before immunostaining for tubulin and phosphorylated RV[S/T]F (p-RV[S/T]F). Nuclei are indicated with DAPI. Control cells were not treated with any inhibitor. More than 50 cells were imaged for each condition in three independent experiments. Scale bar, 20 μm.

    Science, 2018, 11(530), doi: 10.1126/scisignal.aai8669. BI 2536 purchased from Selleck.

    Comparison between Genetic Ablation of Cdc20 and Current Mitotic Drugs (C) Transformed Cdc20(lox/lox); RERT(+/Cre) MEFs were subcutaneously injected into the two flanks of SCID mice, and tumors were scored every 2-3 days.These mice were injected i.p. (three injections per week) with 4-OHT or mitotic drugs (taxol, vincristine, and BI2536) when tumors reached about 200 mm3 of volume (day 11; arrow) (n = 8 mice per group). (D) Representative images of these fibrosarcomas 3 days after injection with 4-OHT (to generate Cdc20(D/D) cells), BI2536, or taxol. These mice were injected with 10 μM BrdU to score DNA replication. CA3, immunodetection of active caspase 3. Scale bars, 50 or 10 μM (insets).

    Cancer Cell 2010 18, 641–654. BI 2536 purchased from Selleck.

  • (a,b) RPE1 cells transfected with control or either of two B56-PP2A siRNA pools (1, 2) were incubated in MG132 (10µM, 15 min), followed by the addition of BI2536 (40 nM) or DMSO for 45 min. (a) The frequency of mitotic cells with few or absent cold-stable K-bres . (b) Maximum-intensity projection of tubulin (green) and an overlay with kinetochores (CREST, red) in B56-PP2A-siRNA (pool 2) cells treated with DMSO or BI2536 (40 nM). Insets are 3 enlargement of the optical sections spanning the outlined centromeres.

    Nat Cell Biol 2011 13, 1265-71. BI 2536 purchased from Selleck.

    (a) HeLa Tet-On cells were treated with the indicated siRNAs, arrested in mitosis using 500 nM nocodazole (Noc) and 10 μM MG132, and then treated with or without BI 2536. The endogenous Cdc20 was immunoprecipitated from these cells and blotted with the indicated antibodies. The mitotic index of each sample is indicated below each lane. The bottom graph shows the quantification of the Cdc20-pS92 signal normalized to the total Cdc20 signal (mean±range; n=2 independent experiments).

    Nat Commun, 2016, 7:10818. BI 2536 purchased from Selleck.

  • Treatment with BI 2536 induces cell-cycle arrest in NB TICs and aberrant accumulation of cyclin B1 and p21. C, expression of cyclin B1 and p21 was assessed in NB88R2 following 16 and 24-hour treatment with different doses of BI 2536 (10, 30, and 100 nmol/L). ERK1 (extracellular signal regulated kinase 1) was used as the loading control. D, inhibition of PLK1 was assessed by in vitro kinase assay following treatment of NB88R2 for 3 hours with BI 2536.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

    Treatment with BI 2536 induces cell death via apoptosis. A,treatment with BI 2536 (10, 30, and 100 nmol/L) reduces viable cell numbers as assessed by trypan blue exclusion. B, representative Western blot demonstrating accumulation of cleaved PARP following treatment with 10 nmol/L BI 2536.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

  • BI 2536 inhibits NB tumor growth in vivo. A and B, NOD/SCID mice bearing 50- to100-mm3 tumors were injected intravenously with either vehicle (0.1N HCl per saline) or 12.5 to 25 mg/kg BI 2536 for 2 consecutive days a week, for a total of 3 cycles.Two independent experiments were performed in each case with 5 animals per group. Representative tumor growth data are shown.

     

     

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

    animals with 50- to 100-mm3 tumors were randomized into 4 groups: group 1 injected intravenously with vehicle (0.1N HCl per saline), group 2 injected intravenously with 12.5 mg/kg of BI 2536 (2 consecutive days, 3 cycles), group 3 injected i.p. with 10 mg/kg of irinotecan (3 doses total, 3 days apart), and group 4 injected with BI 2536 and irinotecan. Both representative tumor growth data and a Kaplan-Meyer survival plot are shown.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

  • Plk-1 knockdown and inhibition by BI 2536 and viability of human melanoma cell lines M14 and WM-115 as demonstrated by MTT assay. Experiments were performed in triplicate. One representative experiment is shown. *P<0.001, ANOVA test with Tukey’s post-test. ANOVA, analysis of variance; MTT, 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; Plk-1, polo-like kinase 1; siRNA, small-interfering RNA; WB, western blot.

    J Invest Dermatol 2011 131, 1886–1895. BI 2536 purchased from Selleck.

    Western blot analysis of the expression and phosphorylation of Plk1, and phosphorylation of Myt1 in the CSC-like cells after treatment with BI 2536 for 24 and 48 hours, respectively.

    Oncotarget, 2017, 8(23):37633-37645. BI 2536 purchased from Selleck.

  • Cells with decreased GRK5 expression are more sensitive to PLK1 inhibition.A , shown is cell death in control or GRK5-shRNA stably transfected cells after 72 h of treatment with 0-120 nM BI 2536 as determined by trypan blue exclusion (n = 6).B , shown is cell death in control or GRK5-shRNA stably transfected cells after 72 h treatment with 0 –120 nM GSK461364, as determined by trypan blue exclusion ( n = 4).

    J Biol Chem 2012 287(21), 17088-99. BI 2536 purchased from Selleck.

    J Biomol Screen 2013 18(1), 54-66. BI 2536 purchased from Selleck.

  • Example dose response curves of the PLK-1 inhibitor BI-2536. During the large dose response study for each reference compounds 8 dilutions were tested. Curves for IC50 determination for two independent experiments for the PLK1 inhibitor BI-2536 are displayed. This inhibitor is also used to achieve the LC values. IC50 has been determined with 7.48 +/- 0.09 log [M] and 6.75 +/- 0.21 log [M]. Correlating assay performance data are displayed in Suppl. Fig. 5. 

    J Biomol Screen 2013 18(1), 54-66. BI 2536 purchased from Selleck.

产品安全说明书

PLK抑制剂选择性比较

生物活性

产品描述 BI 2536是一种有效的Plk1抑制剂，无细胞试验中IC50为0.83 nM，比作用于Plk2和Plk3选择性分别高4和11倍。Phase 2。
特性 BI 2536是第一个有效的Plk1选择性抑制剂，抑制 Plk1的标记。
靶点
PLK1 [1]
(Cell-free assay)		 PLK2 [1]
(Cell-free assay)		 PLK3 [1]
(Cell-free assay)
0.83 nM 3.5 nM 9.0 nM
体外研究

除了Plk1, BI 2536也抑制 Plk2 和Plk3活性，只是抑制程度低点,IC50分别为3.5 nM和9.0 nM。BI 2536比一组63种其他蛋白激酶（IC50>10 μM）选择性高1000多倍。BI 2536 按10 nM 到 100 nM剂量作用于HeLa细胞，抑制有丝分裂中心体中γ-微管蛋白招募和Apc6 磷酸化，抑制染色体臂中释放黏结蛋白, 诱导产生单极主轴，及一些依赖Plk1的其他有丝分裂过程。与作用于Plk1 RNAi效果相一致, BI 2536处理HeLa细胞，使细胞周期停在G2/M期, 随后DNA分解及凋亡，且累积断裂的PARP p85片段，这种作用存在浓度依赖性。BI 2536抑制一组32种人肿瘤细胞系生长，EC50为2-25 nM,抑制指数生长的hTERT-RPE1,人脐静脉内皮细胞 (HUVECs),和正常大鼠肾脏(NRK) 细胞的增殖，EC50为12-31 nM。[1] BI 2536 抑制Plk1，降低甲状腺未分化癌(ATC)细胞如 CAL62, OCUT-1, SW1736, 8505C,和 ACT-1 的生长的生长和活力，EC50为1.4-5.6 nM。[2]
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PSN1 M3yyV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTBwMEC3O|Yh|ryP MYfTRW5ITVJ?
ACN NV60VW1ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXr5NVBlUUN3ME2wMlAxQDR|IN88US=> NHiye4ZUSU6JRWK=
TE-8 NHjxZoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvWcpJKSzVyPUCuNFA6PDFizszN MV7TRW5ITVJ?
LC-2-ad NITOW|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTBwMEGwPVMh|ryP MXrTRW5ITVJ?
ALL-PO MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nMemlEPTB;MD6wNVMh|ryP MnzuV2FPT0WU
EW-16 MorOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fmcmlEPTB;MD6wNVM{PiEQvF2= NX7L[VBUW0GQR1XS
KM12 MoTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTBwMEGzOFgh|ryP NVPJWmxNW0GQR1XS
GI-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1q3fGlEPTB;MD6wNVM5OyEQvF2= NXK3e|ZYW0GQR1XS
LS-411N MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTBwMEG0NFch|ryP MVHTRW5ITVJ?
ES8 M3vM[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3m0fGlEPTB;MD6wNVQ6PCEQvF2= M2\kVHNCVkeHUh?=
SNU-C2B MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYn5R4RRUUN3ME2wMlAyPTJ4IN88US=> MU\TRW5ITVJ?
CESS M{nqe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{K4emlEPTB;MD6wNVYxOiEQvF2= Mo\kV2FPT0WU
697 MoW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DhdmlEPTB;MD6wNVY3QCEQvF2= MoTxV2FPT0WU
NCI-H1963 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPEUlRKSzVyPUCuNFE3PzNizszN M1nzTHNCVkeHUh?=
IA-LM MojwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTBwMEG2PFgh|ryP MXzTRW5ITVJ?
SW954 NIPSdoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4S1VmlEPTB;MD6wNVcxPSEQvF2= NEjIcJZUSU6JRWK=
RL95-2 MlywS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTBwMEG3N|gh|ryP M1TtVHNCVkeHUh?=
LXF-289 M1PPfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnLfWxZUUN3ME2wMlAyPzdizszN NHu4[VJUSU6JRWK=
OCUB-M M1G4N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzzS3l4UUN3ME2wMlAyQDJ4IN88US=> NHyxOHVUSU6JRWK=
RKO M4H4e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwMEG5PFch|ryP NFLhW4lUSU6JRWK=
LOUCY NITHc2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUK2eJp5UUN3ME2wMlAzODVizszN Moq4V2FPT0WU
NOS-1 NGP4XI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrXTWM2OD1yLkCyNFk{KM7:TR?= MlzoV2FPT0WU
A4-Fuk M1znWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTBwMEKyNVgh|ryP NXTuNm9UW0GQR1XS
A388 NUTFU5Q3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlj0TWM2OD1yLkCyNlI4KM7:TR?= MXzTRW5ITVJ?
TE-9 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\xVJNKSzVyPUCuNFIzPjFizszN NXr6[m1IW0GQR1XS
KURAMOCHI MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojkTWM2OD1yLkCyNlg2KM7:TR?= Mnn2V2FPT0WU
KALS-1 M4nnUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTCTWM2OD1yLkCyN|M5KM7:TR?= MmXCV2FPT0WU
HOP-62 NHTSc3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDkTWM2OD1yLkCyOFIh|ryP NUn0U2s5W0GQR1XS
RPMI-8402 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwMEK1NFgh|ryP NIfvcY5USU6JRWK=
TE-1 NYPjcGlIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTBwMEK1NVIh|ryP MV\TRW5ITVJ?
CCRF-CEM NGjqPYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwMEK1OFMh|ryP NFvtZm1USU6JRWK=
HUTU-80 NUL4RWNLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPkTWM2OD1yLkCyOlI1KM7:TR?= MXvTRW5ITVJ?
NCI-H1648 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkG4TWM2OD1yLkCyOlQ4KM7:TR?= MmjWV2FPT0WU
HCE-4 MmHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3UcFRyUUN3ME2wMlAzPjh{IN88US=> MVvTRW5ITVJ?
ETK-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnNVYhYUUN3ME2wMlAzPzN4IN88US=> MYrTRW5ITVJ?
TE-15 MnnDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nZWWlEPTB;MD6wNlc{QCEQvF2= M{OzTHNCVkeHUh?=
BE-13 NF\CZ|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFW0NldKSzVyPUCuNFI4PCEQvF2= MUTTRW5ITVJ?
KE-37 M{Wxb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rKR2lEPTB;MD6wNlc1OSEQvF2= NFrG[nZUSU6JRWK=
NCI-H1355 Mn23S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTBwMEK3PFMh|ryP NVzRRZM3W0GQR1XS
TE-11 NWjZOmNvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4r2bmlEPTB;MD6wNlgxQSEQvF2= MX3TRW5ITVJ?
BL-70 MmjyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDjVWV{UUN3ME2wMlAzQDV5IN88US=> NEDLb5dUSU6JRWK=
ES6 M1qwZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTBwMEK4PFEh|ryP NXTwN45PW0GQR1XS
GT3TKB NEnWR2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPLbmNQUUN3ME2wMlAzQTV|IN88US=> NVjLbndGW0GQR1XS
LB647-SCLC NIewdllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkS1TWM2OD1yLkCzNVk2KM7:TR?= MY\TRW5ITVJ?
NB13 MmjKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTBwMEOzNVYh|ryP NIj2NIhUSU6JRWK=
ST486 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\pbZV1UUN3ME2wMlA{OzN5IN88US=> MWjTRW5ITVJ?
NCI-H82 NFnzZlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moe5TWM2OD1yLkCzN|Q{KM7:TR?= MV\TRW5ITVJ?
NTERA-S-cl-D1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknDTWM2OD1yLkCzN|k6KM7:TR?= NGjhTGpUSU6JRWK=
ES4 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfsUoJZUUN3ME2wMlA{PDZ|IN88US=> MVfTRW5ITVJ?
SK-NEP-1 M3PaTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYf3cXpDUUN3ME2wMlA{PDl7IN88US=> MonSV2FPT0WU
Becker NWrrNWZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwMEO1OVUh|ryP MkLYV2FPT0WU
A101D NEnxVWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2i5W2lEPTB;MD6wN|c1QCEQvF2= M{fkVXNCVkeHUh?=
SK-UT-1 Mn;IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TtO2lEPTB;MD6wN|c4PCEQvF2= NU\WeHlWW0GQR1XS
SW982 MoW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1:3ZWlEPTB;MD6wN|c6KM7:TR?= NIrvZlhUSU6JRWK=
TE-10 MlHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXOTWM2OD1yLkC0NFQ3KM7:TR?= NWW1PXdoW0GQR1XS
OVCAR-4 NXS1T4txT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTUfWVKSzVyPUCuNFQxPTlizszN M1;MbHNCVkeHUh?=
KP-N-YS MorBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlixTWM2OD1yLkC0NFg2KM7:TR?= Mle0V2FPT0WU
BL-41 M2KzSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLyPVlKSzVyPUCuNFQyOjVizszN MoT5V2FPT0WU
MZ1-PC M1XQOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnH2TWM2OD1yLkC0NVI4KM7:TR?= MXfTRW5ITVJ?
PF-382 NFj3doFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTBwMESxPVgh|ryP NFvHd|ZUSU6JRWK=
MOLT-13 M3O3VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwMESyN|gh|ryP MXnTRW5ITVJ?
HCC1599 M1;FZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfNTWM2OD1yLkC0NlU5KM7:TR?= M13BUnNCVkeHUh?=
IST-MEL1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXTTWM2OD1yLkC0OFQzKM7:TR?= Ml[4V2FPT0WU
LU-139 NIftTFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DzXWlEPTB;MD6wOFQ1OiEQvF2= NHXMbI5USU6JRWK=
MS-1 NIfJUotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHmNI1jUUN3ME2wMlA1PzBzIN88US=> M4TQ[XNCVkeHUh?=
MFH-ino NXzTUJR2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPmTWM2OD1yLkC1NFA{KM7:TR?= M4X5NXNCVkeHUh?=
IMR-5 M3LKcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzwNVU4UUN3ME2wMlA2ODJzIN88US=> NVWycXh{W0GQR1XS
TE-5 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTBwMEWwOlMh|ryP MlWyV2FPT0WU
DJM-1 NV3z[GhPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLPb2xKSzVyPUCuNFUyPDJizszN MXPTRW5ITVJ?
NB17 M3XZNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPQZYhPUUN3ME2wMlA2OjB5IN88US=> M{[0ZnNCVkeHUh?=
KARPAS-45 NH62XJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGG1ZmxKSzVyPUCuNFU{PThizszN NX34bIJHW0GQR1XS
TGBC1TKB MlT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTBwMEW0NFUh|ryP NFLXUpRUSU6JRWK=
ML-2 NHL0SmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXHdmdjUUN3ME2wMlA2PDF2IN88US=> Mnf2V2FPT0WU
no-10 NWn3N4IyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\STmlEPTB;MD6wOVQ4PCEQvF2= NFLmSY9USU6JRWK=
CTV-1 MnL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTqVWdKSzVyPUCuNFU2ODJizszN M2KydnNCVkeHUh?=
SJSA-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jvb2lEPTB;MD6wOVUzKM7:TR?= NUPnPXFvW0GQR1XS
HC-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4naVGlEPTB;MD6wOVU6PyEQvF2= MXTTRW5ITVJ?
TE-12 M4TZOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkCzTWM2OD1yLkC1OlE{KM7:TR?= NYnkWG9UW0GQR1XS
KY821 M1fMSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVW4WXNiUUN3ME2wMlA2PjN{IN88US=> NYjGVYJWW0GQR1XS
TALL-1 M4rpdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULRS5kyUUN3ME2wMlA2PzB6IN88US=> MoC0V2FPT0WU
DEL MlXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXBTWM2OD1yLkC1O|A6KM7:TR?= NIfi[IZUSU6JRWK=
TE-6 M2i3VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\WbIc5UUN3ME2wMlA2PzJ{IN88US=> NFTBclJUSU6JRWK=
SK-LMS-1 M4DhZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXr[4JqUUN3ME2wMlA2QDB3IN88US=> Mlu2V2FPT0WU
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RPMI-8226 NIn2RYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHWU2VwUUN3ME2wMlEzODV{IN88US=> NWDQdmF2W0GQR1XS
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SCLC-21H M2m0Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfHS3hUUUN3ME2wMlE2PzB{IN88US=> MU\TRW5ITVJ?
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MC116 NH6wd|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHVS4xsUUN3ME2wMlE3OTV6IN88US=> MYXTRW5ITVJ?
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UACC-257 NX;NRZpUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33qXWlEPTB;MD6xPVk1PyEQvF2= NXn5c3J{W0GQR1XS
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NCI-H720 MkS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4KyNWlEPTB;MD6yNFUzPSEQvF2= NGDLUJRUSU6JRWK=
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NCI-H1436 NVyzc5VrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXm0eIJqUUN3ME2wMlIyPDZ2IN88US=> NFexc4hUSU6JRWK=
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SIG-M5 NVezNZBwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrtTWM2OD1yLkKyO|I4KM7:TR?= MVfTRW5ITVJ?
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LB1047-RCC MkD1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVP1cFZrUUN3ME2wMlI1PDFizszN NV3hUWRuW0GQR1XS
CTB-1 M1fVUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rGXmlEPTB;MD6yOFQ6OyEQvF2= NWP2SJJZW0GQR1XS
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KARPAS-422 M1;0Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUi5dGlHUUN3ME2wMlI2PDN3IN88US=> NXfHR2I2W0GQR1XS
MEG-01 NWS2S|R2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfzNGNlUUN3ME2wMlI2Pjd|IN88US=> NH;JSWZUSU6JRWK=
NCI-H209 NHPvR|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHW3b2FKSzVyPUCuNlY{PzRizszN NF;ZSIZUSU6JRWK=
SBC-1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jobGlEPTB;MD6yOlUh|ryP NWi0XmtwW0GQR1XS
K5 M1T1XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DobmlEPTB;MD6yOlk5PCEQvF2= NELvZ|VUSU6JRWK=
QIMR-WIL NV3PVlZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHv3ZZpKSzVyPUCuNlcyPTVizszN NEDCNGpUSU6JRWK=
NMC-G1 M4PMdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHz6bINKSzVyPUCuNlgzOTdizszN M3TRO3NCVkeHUh?=
IST-MES1 M3LGPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHWTWM2OD1yLkK5NlM5KM7:TR?= M3nSSXNCVkeHUh?=
SW684 Ml7ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEH1eZRKSzVyPUCuN|AxPDdizszN MYLTRW5ITVJ?
MV-4-11 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVf2U|c4UUN3ME2wMlMxPzh6IN88US=> MXHTRW5ITVJ?
LAN-6 NWWzOGtxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlyyTWM2OD1yLkOxOVczKM7:TR?= MXLTRW5ITVJ?
RH-1 MlW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIm1cG5KSzVyPUCuN|E5PzFizszN NX:5PFl3W0GQR1XS
CP66-MEL M4jsS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HqdmlEPTB;MD6zNVg4QCEQvF2= M2H2dHNCVkeHUh?=
EC-GI-10 NWjxWJl4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTBwM{K5PFch|ryP M{npcXNCVkeHUh?=
GDM-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjTSYpKSzVyPUCuN|MxPTlizszN M1rLXHNCVkeHUh?=
IST-SL1 NFWyZW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwM{S5NVQh|ryP NEDtb5pUSU6JRWK=
KMOE-2 M{fIZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFS3RoNKSzVyPUCuN|UyPzVizszN MX3TRW5ITVJ?
OS-RC-2 MlfDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoX6TWM2OD1yLkO1OVQ1KM7:TR?= MVfTRW5ITVJ?
HDLM-2 NXLDNZBPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{L5OmlEPTB;MD6zO|gyPCEQvF2= NFXE[mVUSU6JRWK=
DSH1 NH\iUm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfTcplKSzVyPUCuN|g3OzFizszN NWDa[WJOW0GQR1XS
LS-1034 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPLbnVKSzVyPUCuN|g6PTRizszN M1TBTnNCVkeHUh?=
LB373-MEL-D MmL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml32TWM2OD1yLkO5NVk4KM7:TR?= NYf6WpF[W0GQR1XS
GOTO MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nWXGlEPTB;MD60NlEyQCEQvF2= MYPTRW5ITVJ?
MRK-nu-1 NHjpOYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDrTWM2OD1yLkSyNlA2KM7:TR?= NIHwc49USU6JRWK=
SK-MM-2 MnS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvRNWpsUUN3ME2wMlQ{PDR{IN88US=> NX24[WZPW0GQR1XS
BOKU MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTBwNEO3PVIh|ryP MYDTRW5ITVJ?
NOMO-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTBwNEO4OkDPxE1? MoP4V2FPT0WU
J-RT3-T3-5 NUCyVXZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwNES4O|gh|ryP MXLTRW5ITVJ?
COLO-668 M3jjUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\YRlRKUUN3ME2wMlQ2PjZ6IN88US=> M2TiUXNCVkeHUh?=
SF539 NEfNXodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPOe3dGUUN3ME2wMlQ5Pjh2IN88US=> Ml;qV2FPT0WU
LB2518-MEL MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mny3TWM2OD1yLkS5O|A{KM7:TR?= M2Lw[3NCVkeHUh?=
TE-441-T MnnIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\4cZdKSzVyPUCuOVAyOiEQvF2= MnjIV2FPT0WU
MDA-MB-134-VI NILvUVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorzTWM2OD1yLkWwPVIyKM7:TR?= MlruV2FPT0WU
SCC-3 M1;k[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwNUG4O|Mh|ryP MoPOV2FPT0WU
KLE NFW4WG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moq1TWM2OD1yLkWyNVcyKM7:TR?= M1\RR3NCVkeHUh?=
LB2241-RCC MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjnTWM2OD1yLkWyOVI2KM7:TR?= NXXKTJNIW0GQR1XS
NCI-H1417 NUP1R5NPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DPNGlEPTB;MD61N|Q{PSEQvF2= MkfiV2FPT0WU
NCI-H2081 MlrXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY[5[4RmUUN3ME2wMlU5PjFzIN88US=> Mn\nV2FPT0WU
NCI-H1522 NIiwcodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwNUmzPFMh|ryP NGjzc2lUSU6JRWK=
NCI-H889 NF:1TGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4X2PWlEPTB;MD61PVg1PCEQvF2= NWXQUHptW0GQR1XS
CGTH-W-1 M{TqXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\GTWM2OD1yLk[wO|U2KM7:TR?= NE\uRYRUSU6JRWK=
EB-3 NULmSFU5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTBwNkGxOVMh|ryP MUjTRW5ITVJ?
D-336MG M1HKT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nRVGlEPTB;MD62NVc6OSEQvF2= MnzCV2FPT0WU
LC-1F M{\iS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWq5PVU1UUN3ME2wMlYzPTl{IN88US=> NXPDfmY3W0GQR1XS
MHH-NB-11 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2foZ2lEPTB;MD62N|gxOSEQvF2= M2X1NnNCVkeHUh?=
SK-N-FI NFLWelNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwNkO5NUDPxE1? NWfOVlZpW0GQR1XS
NCI-H69 M{PNdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHjSJZKSzVyPUCuOlQ5PzlizszN NGXlSoVUSU6JRWK=
SCH MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTZfoxKSzVyPUCuOlYxOjNizszN M33C[3NCVkeHUh?=
LS-513 M2nPfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwNkeyOVkh|ryP MVLTRW5ITVJ?
CP67-MEL M2m1eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHHRVJKSzVyPUCuOlc2QTZizszN NWTFRmcxW0GQR1XS
GCIY MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLzTWM2OD1yLkewN|Y{KM7:TR?= MmGxV2FPT0WU
SHP-77 NFPTUmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTBwN{C3N|Qh|ryP M{DtSXNCVkeHUh?=
EHEB M{nBOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rJWWlEPTB;MD63NVg2PCEQvF2= MlvmV2FPT0WU
D-247MG NH3yV2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4WwUmlEPTB;MD63N|I{OiEQvF2= MlL2V2FPT0WU
Raji NInHcplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofCTWM2OD1yLke0PVg6KM7:TR?= MXvTRW5ITVJ?
MPP-89 NIfk[XlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLYTWM2OD1yLke1PVc5KM7:TR?= NY\UbGMzW0GQR1XS
EKVX M{jXRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;xVodKSzVyPUCuO|kxPzNizszN NYD6dmQyW0GQR1XS
HCC2218 M12ybGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnKPXVLUUN3ME2wMlc6OTNzIN88US=> M4LXTXNCVkeHUh?=
KNS-81-FD M3X0R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDwTWM2OD1yLkixNFEyKM7:TR?= NYO5bldYW0GQR1XS
HCC2157 M4jib2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTBwOES5OVEh|ryP M13oU3NCVkeHUh?=
BT-474 NFvJXlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwOEi4OVQh|ryP M1nXSnNCVkeHUh?=
NCI-H748 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwOUGyJO69VQ>? MnXMV2FPT0WU
EW-24 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWKxcXhwUUN3ME2wMlkzODB{IN88US=> Mmn6V2FPT0WU
D-263MG M1ziZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;6S|JKSzVyPUCuPVQ2OTJizszN NYf6UIl6W0GQR1XS
OMC-1 NETFU2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTBwOU[zO|Mh|ryP MXvTRW5ITVJ?
NCI-H2196 M{\wVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPMN|d[UUN3ME2wMlk4Pzd5IN88US=> NUiwNo9mW0GQR1XS
HAL-01 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\yOoZ7UUN3ME2wMlk6QDd{IN88US=> MVLTRW5ITVJ?
NCI-H2107 M33mN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHFRlFKSzVyPUGuNFE5PTRizszN MWXTRW5ITVJ?
LB996-RCC M4X5SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\sTWM2OD1zLkC4NFUyKM7:TR?= NEfBb5dUSU6JRWK=
NCI-H1395 NVewZo1uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3Kx[2lEPTB;MT6xNFY4KM7:TR?= MUDTRW5ITVJ?
CHP-126 NHr5bpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTFwMU[xPVkh|ryP MnLnV2FPT0WU
NB69 Ml;sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTFwMk[xOFgh|ryP NWXpR|loW0GQR1XS
CAS-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILaVFdKSzVyPUGuN|QzOzFizszN MWfTRW5ITVJ?
JVM-3 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\aUWlEPTB;MT60O|g2PSEQvF2= MXjTRW5ITVJ?
DMS-153 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlH1TWM2OD1zLkW3Olc1KM7:TR?= NYXGS4V1W0GQR1XS
SK-MEL-2 NEDPPJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\abnhKSzVyPUGuO|E4QDlizszN NF;CN2RUSU6JRWK=
NCI-H1155 NEDRV|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHDb4lKSzVyPUGuO|M3PzZizszN NFLtT29USU6JRWK=
NCI-H1092 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrqRZpKSzVyPUGuO|YyQDJizszN NWHQRoJ3W0GQR1XS
LU-165 NEjaOpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTFwOE[0O|Yh|ryP M2PjTHNCVkeHUh?=
HL-60 MnHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTFwOUm5NFgh|ryP NWLPdZpUW0GQR1XS
REH NEGyXZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1O2SWlEPTB;Mj6wNFU5OiEQvF2= NX\zVVFEW0GQR1XS
JVM-2 NGficVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TyWmlEPTB;Mj6wOlE{PSEQvF2= MnfaV2FPT0WU
MN-60 M{D2[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nwe2lEPTB;Mj6xO|MxQCEQvF2= M{XwcHNCVkeHUh?=
SCC-15 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTJwMkCyO{DPxE1? Mlv2V2FPT0WU
SNU-C1 NELi[|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInjNlZKSzVyPUKuNlE{PDNizszN NXns[2hxW0GQR1XS
SK-MEL-1 MkTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrTb2NpUUN3ME2yMlMzODR5IN88US=> MYDTRW5ITVJ?
TGW NE[1R2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTJwM{WwNlch|ryP NXjGSnEzW0GQR1XS
CA46 NFXyXIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1foN2lEPTB;Mj63OVk3PyEQvF2= M2GxfHNCVkeHUh?=
NCI-H23 NFfDbYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvVTWM2OD1{LkiwO|kyKM7:TR?= M1;JR3NCVkeHUh?=
MMAC-SF M4LiVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTJwOE[2Nlgh|ryP M{PVR3NCVkeHUh?=
NCI-H2171 NGDRXlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXuTWM2OD1|LkCzOFQ5KM7:TR?= NFH1cpdUSU6JRWK=
A704 M2rHb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTNwMUSxPVQh|ryP NHzQfZFUSU6JRWK=
DB NIXYfVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjmb2lKSzVyPUOuNlU2PzZizszN MnHXV2FPT0WU
NCI-H719 NHmzcXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTNwM{CzPFQh|ryP NX;Od4x2W0GQR1XS
MC-CAR MlvsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTNwNUS4NVch|ryP NWrxeYx{W0GQR1XS
SIMA MlnFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTNwNUi0NVYh|ryP NH3LbJlUSU6JRWK=
SW872 NV7r[pl5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fi[mlEPTB;Mz63PFExOSEQvF2= MlXSV2FPT0WU
HCC1187 MmjuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3rTWM2OD1|Lke4N|E2KM7:TR?= NYG3RmNnW0GQR1XS
EW-13 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LlXmlEPTB;Mz64N|QyPyEQvF2= NFPHVIRUSU6JRWK=
NCI-SNU-1 M4X3bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rCNWlEPTB;ND6yNVk6QSEQvF2= MYrTRW5ITVJ?
NCI-H226 M1K2dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2j4bmlEPTB;ND6zN|YxPiEQvF2= M4nKOHNCVkeHUh?=
RPMI-8866 M33YSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LQbWlEPTB;ND6zOlAzQSEQvF2= MWTTRW5ITVJ?
OCI-AML2 NX7ZbFByT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvKTWM2OD12LkW1NlMh|ryP NYHJdJBuW0GQR1XS
LU-65 M2\ZPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTxTWM2OD12LkmzNFM{KM7:TR?= MnvRV2FPT0WU
SK-N-DZ MnvvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGWwVGdKSzVyPUWuOlM1PjVizszN NVHVZ5pxW0GQR1XS
NB14 NVH2NXpST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV32[odbUUN3ME21Mlk4OTN3IN88US=> Ml;GV2FPT0WU
COLO-829 Mmf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nFTWlEPTB;Nj6zN|M2QSEQvF2= NVzxeW4{W0GQR1XS
MHH-CALL-2 M2PsSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXlR5h7UUN3ME22MlUyPTB6IN88US=> NWrjOWNZW0GQR1XS
NCI-H1770 M2i3WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzpUmJKSzVyPU[uOlY6ODRizszN NWjDOIFLW0GQR1XS
ECC4 NH;mdGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTZwOEKxO|kh|ryP MUnTRW5ITVJ?
A498 MnvNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zSRmlEPTB;Nj64O|E6OiEQvF2= Mk\rV2FPT0WU
DMS-79 NWfrdWRkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTdwMES1NVIh|ryP M4fLN3NCVkeHUh?=
P30-OHK MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPa[VRKSzVyPUeuNlE6ODZizszN MVLTRW5ITVJ?
D-502MG MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTdwOUizOkDPxE1? MlHkV2FPT0WU
RCC10RGB NGDMUnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV:2Zo5mUUN3ME24MlA3OjhizszN NET6VmZUSU6JRWK=
U-698-M MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRThwMkmyNlYh|ryP NELkR2RUSU6JRWK=
BB49-HNC MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzuNIhKSzVyPUmuOFIzPjVizszN NYn3c5h{W0GQR1XS
ES1 NFXCc2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTlwNki5OVYh|ryP Mn\FV2FPT0WU
MFM-223 NF7HbGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFq1SYNKSzVyPUGwMlk6OjdizszN NFfFVJNUSU6JRWK=
C2BBe1 NUTvVHBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjO[lhKSzVyPUGxMlM2OjNizszN M2[xfnNCVkeHUh?=
EB2 M1ryWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGr4VHFKSzVyPUGyMlY5QDFizszN MWjTRW5ITVJ?
C8166 NX;ydZVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHi1TW5KSzVyPUGzMlg{ODNizszN MUjTRW5ITVJ?
ES3 MnLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3RcXlnUUN3ME2xN{46QTd5IN88US=> NXH1VpJRW0GQR1XS
NCI-H1650 NH7ydWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvFS|lEUUN3ME2xOk4{PzZ3IN88US=> NUTlR484W0GQR1XS
Mo-T NGW1[|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH24VXZKSzVyPUG3MlQxOjlizszN NE\mVXZUSU6JRWK=
NB7 Mkn5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHB[IVKSzVyPUG3Mlc1PjdizszN M3vpN3NCVkeHUh?=
ES7 M1XOcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moj1TWM2OD1zOT61OVA4KM7:TR?= NGPYZpdUSU6JRWK=
ES5 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\COWlEPTB;MkGuO|Y4OSEQvF2= MYTTRW5ITVJ?
MSTO-211H NFKyTFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\xWphKSzVyPUKxMlg5PThizszN M{LYWHNCVkeHUh?=
U-87-MG M{jJemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HN[WlEPTB;MkWuNVk3PiEQvF2= NUDzcWx7W0GQR1XS
THP-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLuTWM2OD1{OT63NlAyKM7:TR?= MoXRV2FPT0WU
NB10 NUTwe2l5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLaTWM2OD1|MD6yOlk1KM7:TR?= NIjmRWRUSU6JRWK=
NH-12 NI\jVnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTN|LkKwNVch|ryP NHPRWZlUSU6JRWK=
COLO-824 NICxVHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7Mc|VKSzVyPUO0MlExODZizszN NYTSUYV[W0GQR1XS
SKM-1 NU\TWGwxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnlTWM2OD1|Nz64OFIzKM7:TR?= M3;0UHNCVkeHUh?=
NCI-H1838 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmmwTWM2OD1|OD6zO|k4KM7:TR?= MUDTRW5ITVJ?
RL NXn6d4VIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHn6W3NKSzVyPUO5MlI1PzdizszN NI\kN2FUSU6JRWK=
COLO-800 MnHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULEPVVDUUN3ME20NE4xPzd|IN88US=> NFvuNpFUSU6JRWK=
KG-1 NUPtelZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PPNWlEPTB;NECuPFk2PSEQvF2= NUnKbGF3W0GQR1XS
TUR NHPWS2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTRzLk[zPVkh|ryP MoPKV2FPT0WU
LNCaP-Clone-FGC NHzCWGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDiSpJRUUN3ME20NU46ODF5IN88US=> MV3TRW5ITVJ?
NCI-H322M MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrmbGtKSzVyPUSyMlU6QDRizszN NYXsTFVLW0GQR1XS
LNCaP  MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIntUHZKSzVyPUmxMlMhdk1? M{fNOVI2PTB3MUe0
C4-2 NIDq[WFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rsemlEPTB;ODDuUS=> NVXaNYdqOjV3MEWxO|Q>
JURKAT NX;mbI9nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGH6N2MzPCCq NWTORlBQUUN3ME20NVYvPjZibl2= NFnE[XozPDVzOUm5OS=>
MOLT-4 NUf4N3dXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYCyOEBp M2flOmlEPTB;Mki1N{42KG6P NEjr[IQzPDVzOUm5OS=>
REH NYPIUI1yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUWyOEBp NYDrWGNxUUN3ME2yPFcvPjhibl2= NGC3eJMzPDVzOUm5OS=>
NALM-6 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV2yOEBp NGewTItKSzVyPUO0N|MxKG6P M2HxOlI1PTF7OUm1
RS 4;11 NGHIOINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnj2NlQhcA>? MUHJR|UxRTVzOT6wOUBvVQ>? NWL0ZppDOjR3MUm5PVU>
697 NWfBeopwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDtTHYzPCCq MUjJR|UxRTJzMEeuNUBvVQ>? M{fqO|I1PTF7OUm1
SIL-ALL M2LG[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXF[2EzPCCq MYLJR|UxRTF7OT63O{BvVQ>? MXWyOFUyQTl7NR?=
CEM M13u[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;uNlQhcA>? M3rSVGlEPTB;NUKuNVghdk1? M2PWeVI1PTF7OUm1
P12 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjiNlQhcA>? Mn3UTWM2OD1|OT6yO{BvVQ>? MlHFNlQ2OTl7OUW=
NALM-16 NF\GeYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofSNlQhcA>? NG\2dG1KSzVyPUm2MlI5KG6P MViyOFUyQTl7NR?=
JURKAT NFLJOJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmq5OFghcA>? MknmTWM2OD1zND64OEBvVQ>? NHvEboczPDVzOUm5OS=>
MOLT-4 NIWxcINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rsc|Q5KGh? MV3JR|UxRTJ4Lk[gcm0> NITZc44zPDVzOUm5OS=>
REH NG\xWIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnq2OFghcA>? NX\1SHBYUUN3ME20OE44OSCwTR?= MXWyOFUyQTl7NR?=
NALM-6 NGPMXGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXEOFghcA>? MVrJR|UxRTJ|LkK2JI5O M{jKXFI1PTF7OUm1
RS 4;11 Mn7QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHniU|Y1QCCq MUjJR|UxRTF4ND6yPEBvVQ>? MojVNlQ2OTl7OUW=
697 MoXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPUOFghcA>? M2Xh[GlEPTB;M{C1MlMhdk1? MmDsNlQ2OTl7OUW=
SIL-ALL MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV60PEBp MmfGTWM2OD15ND62NkBvVQ>? NFO2[5kzPDVzOUm5OS=>
CEM NHzWR2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDYOFghcA>? MXfJR|UxRTJ2LkW1JI5O NHHCTlkzPDVzOUm5OS=>
P12 NH;yfZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{SxblQ5KGh? NFvS[mNKSzVyPUG4MlQ3KG6P M3LRZ|I1PTF7OUm1
NALM-16 NIHIfnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWX6NVRVPDhiaB?= M{HpSGlEPTB;NkOuNlQhdk1? MWiyOFUyQTl7NR?=
JURKAT M{XOTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TqZlczKGh? MYDJR|UxRTNwNkWgcm0> M4XLe|I1PTF7OUm1
MOLT-4 M2KwTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;jXHA5PzJiaB?= M3fQWGlEPTB;Nz6zPUBvVQ>? MVyyOFUyQTl7NR?=
REH M3nCO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\KRVczKGh? NWnRblZlUUN3ME2xOk4xOSCwTR?= MUCyOFUyQTl7NR?=
NALM-6 M4Gz[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorYO|IhcA>? NVe1c2hXUUN3ME2xMlc5KG6P M3HtNFI1PTF7OUm1
RS 4;11 MnTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTtO|IhcA>? NX;TOJZ2UUN3ME20MlM5KG6P M2PsfVI1PTF7OUm1
697 NXj2XHc6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XBeVczKGh? M1zGcGlEPTB;N{SuNlghdk1? MkLPNlQ2OTl7OUW=
SIL-ALL M1Pobmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWq3NkBp MVnJR|UxRTdwMjDuUS=> NXPwO|lQOjR3MUm5PVU>
CEM NHXMV3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrzT404OiCq M4TU[2lEPTB;NT60NkBvVQ>? MUOyOFUyQTl7NR?=
P12 NUPEW3RKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXSO5M4OiCq MkPKTWM2OD14LkO3JI5O M{K4RlI1PTF7OUm1
NALM-16 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPT[Yw4OiCq NXjB[mFNUUN3ME23O{44OyCwTR?= M1zXZ|I1PTF7OUm1
Y79 MXPBdI9xfG:|aYOgRZN{[Xl? Ml\KNU02OCCwTR?= M1PKflEzNzJ2IHi= MWfEUXNQ NHjEc3pqdmS3Y3XkJIFxd3C2b4Ppd{B4cGmlaDDjZY4h[mViZX7oZY5k\WRiYomgTHQ> M2\1O|I1OzZ4Nk[1
WER-Rb-1 MlLaRZBweHSxc3nzJGF{e2G7 NILDcWEyNTVyIH7N MmD5NVIwOjRiaB?= NFzGS41FVVOR NWiyTnFKcW6mdXPl[EBieG:ydH;zbZMhf2irY3igZ4FvKGKnIHXubIFv[2WmIHL5JGhV MnrpNlQ{PjZ4NkW=
G7 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTNwMzDuUS=> MVSyOFIxPDd|Mx?=
G166 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfEcFNKSzVyPUeuNEBvVQ>? NILQT|AzPDJyNEezNy=>
CB660 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFS5[ZRKSzVyPU[uOEBvVQ>? NVfiTFBJOjR{MES3N|M>
CB1117 MoP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTaUnptUUN3ME2xOU43KG6P NHTjXoczPDJyNEezNy=>
KB-3-1 NWHFcJFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDLb4RMUUN3ME2xMlQ5KMLzIECuOVMhdk1? M4T6[FI{QTZ{NES1
KB-8-5-11 M1vvWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvuTWM2OD13LkCxJOKyKDJwMEGgcm0> Mo\5NlM6PjJ2NEW=
KB-C-1 MojYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfOWYZ7UUN3ME2xOk44PiEEsTC0MlUyKG6P NX7ZSJp{OjN7NkK0OFU>
KB-V-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTJ6MT6yOEDDuSB|MT61O{BvVQ>? NYHSblVYOjN7NkK0OFU>
OVCAR-8 MkHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTdwMUmgxtEhOy54MDDuUS=> MlTQNlM6PjJ2NEW=
NCI-ADR-RES NHj4WIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2H5VWlEPTB;MUK3N{4{OCEEsTCxPVEvOjBibl2= NI\LfYozOzl4MkS0OS=>
MCF7 MkTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLldGtFUUN3ME21MlEyKMLzIEGuOFchdk1? MmXENlM6PjJ2NEW=
MCF7-FLV1000 M1HSWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\RUY9KSzVyPUO5N{4yQCEEsTC3OE45OyCwTR?= MoPwNlM6PjJ2NEW=
S1 M{O2[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTJ2LkOwJOKyKDRwN{Wgcm0> NF;5dJczOzl4MkS0OS=>
S1-M1-80 MnzsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIH5VVJKSzVyPUK2NU4xPiEEsTC0PE4zPSCwTR?= NIXqd2YzOzl4MkS0OS=>
CORL-23/P NIOzOXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\xOlZKSzVyPUSuN|ghyrFiMT6yOUBvVQ>? NVvwcHNTOjN7NkK0OFU>
CORL-23/R MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHT4[HhKSzVyPUWuNVYhyrFiMT64N{BvVQ>? MofCNlM6PjJ2NEW=
NIH3T3 NFrv[|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPQTWM2OD12MD62NEDDuSB2Lkm3JI5O M325fFI{QTZ{NES1
NIH3T3-G185 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTJ2MUOuOFAhyrFiNEKzMlY3KG6P NWTodGdOOjN7NkK0OFU>
pcDNA-HEK293 MkHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXERZJUUUN3ME2yMlc2KMLzIECuOlchdk1? MXuyN|k3OjR2NR?=
MDR19-HEK293 M1PJVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjSTWM2OD16NT61NEDDuSBzMz62O{BvVQ>? NIXE[|gzOzl4MkS0OS=>
R482-HEK293 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTJ3Lkm3JOKyKDRwOUWgcm0> M3[0SFI{QTZ{NES1
MRP1-HEK293 M3L5dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfjcFhKSzVyPUKuPVkhyrFiMT60PUBvVQ>? NFvQ[GozOzl4MkS0OS=>
SF188 NUDFZo5wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXq0OWc2OTBvMUCwJI5O M1;PTVI1NTl4IHi= NHjQXFlFVVOR NUe3WnhCcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZo91cCC2aX3lMUBidmRiY3;uZ4VvfHKjdHnvck0h\GWyZXTlcpQhdWGwbnXy M1[weFI{QDh5NkS1
T98G M1\nNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPTTVcyOC1zMECgcm0> NH\GbI4zPC17NjDo MorDSG1UVw>? MUTpcohq[mm2czDj[YxtKGe{b4f0bEBqdiClb37j[Y51emG2aX;uMUBl\XCnZHXueEBu[W6wZYK= MmX5NlM5QDd4NEW=
DU145 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvEUXNQ NHu3fplKSzVy4pk8OlAhdk1? NIPxRngzOzh6NESyPC=>
LNCaP  MnzxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLVXG9QTE2VTx?= MWPJR|Ux6oj:N{Wgcm0> Mn3NNlM5QDR2Mki=
PC3 NE\vTphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTqS3czTE2VTx?= NYrLe4E2UUN3MPMIwFE4PSCwTR?= NULWWYtVOjN6OES0Nlg>
RT4 NYHDSmpZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTJ5LkKxJI5O M{\Xb|I{Pzl{NkO5
5637 M3Py[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDDPHZKSzVyPUS1MlQ4KG6P NFPq[mwzOzd7Mk[zPS=>
T24 MmjPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3FWWFYUUN3ME23PU4yOiCwTR?= NHm3bowzOzd7Mk[zPS=>
MCF7  NH24c5lHfW6ldHnvckBCe3OjeR?= MlzFNVAxKG6P MYqxJIg> NWP3Vmw1TE2VTx?= NHXkUFlz\WS3Y3XzJJRp\SCrbnT1Z5Rqd25ib3dCpGdz\WJzLNMgV4dsOS{EoGDzNkzDqFOncoDpcoE{NCCjbnVCpHdqe3B{ MnHENlM4PzB{NES=
KB-V1  NIXCdZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7Fc4tKSzVyPUOuPVIh|ryP M4nqSVI{PTl|MUm2
Hec50co MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnLRlNMUUN3ME21JI5O NHjLW40zOzF2Nk[4Oy=>
MDA-MB-468 M2\ZS2Fxd3C2b4Ppd{BCe3OjeR?= NF\pV3QyNzVxMUCgcm0> MUSyOE81QC95MjDo NITQ[I1FVVOR NGHIbY5qdmS3Y3XzJIFxd3C2b4Ppd{BqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> NFe1ZYEzOzF2NEK5OC=>
MCF10A MkjoRZBweHSxc3nzJGF{e2G7 M{LZc|EwPS9zMDDuUS=> MmTxNlQwPDhxN{KgbC=> MmXGSG1UVw>? NU\qdIJscW6mdXPld{BieG:ydH;zbZMhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> M3;MVFI{OTR2Mkm0
Huh-7 M3fudmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWqxM|ExNzFyMD:xNFAxKG6P Ml;kOFghcA>? NYnhXHZ4\GWlcnXhd4V{KHSqZTDj[YxtKH[rYXLpcIl1gSCmb4PlMYRmeGWwZHXueIx6 M{LxVlIzPzR3NUi3
Daoy  NH3VcW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfMTlgyNjh5NT2yOFAhdk1? MoezO|IhcA>? MmfmSG1UVw>? M37HVGlEPTB;NTDuUS=> NF7tN2szOjN7MEK3PS=>
ONS-76 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\3b3UyNjh5NT2yOFAhdk1? M4\oOVczKGh? M1L1fGROW09? NXWxeJplUUN3ME23MlUhdk1? NUf0dGpIOjJ|OUCyO|k>
SUM 149 MoD6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3S2WVAuOTByIH7N MlTqO|IhcA>? M1fmOIlvcGmkaYTzJJRp\SClZXzsJJZq[WKrbHn0fUBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7hdi=> NHzCWmgzOjNyOUmzPS=>
MDA-MB-231 NWXWSYZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnLWFJtOC1zMECgcm0> NIPYXW04OiCq NILnPGVqdmirYnn0d{B1cGViY3XscEB3cWGkaXzpeJkhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7uZZI> M4LQclIzOzB7OUO5
HR5 M3n5bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYCwMVExOCCwTR?= M{K1c|czKGh? MXvpcohq[mm2czD0bIUh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wYYK= MYWyNlMxQTl|OR?=
BT-474-M1 Ml;oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoH0NE0yODBibl2= MnXZO|IhcA>? NYH2ZVRXcW6qaXLpeJMhfGinIHPlcIwhfmmjYnnsbZR6KGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoFz NInSU3EzOjNyOUmzPS=>
AU565 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDXNE0yODBibl2= MWm3NkBp MmPmbY5pcWKrdIOgeIhmKGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnHy MUGyNlMxQTl|OR?=
T47D MoPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWi0TYZ4OC1zMECgcm0> MUO3NkBp NUfHcJJScW6qaXLpeJMhfGinIHPlcIwhfmmjYnnsbZR6KGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoFz MU[yNlMxQTl|OR?=
MCF7 MkO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mly1NE0yODBibl2= MY[3NkBp MX;pcohq[mm2czD0bIUh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wYYK= NF;KR|YzOjNyOUmzPS=>
HCT116p53(+/+) M1rBemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYK1XFVlOTBvMUCwNEBvVQ>? MWSyOE81QCCq MWnpcohq[mm2czDj[YxtKHC{b3zp[oVz[XSrb36gZ49ueGyndHXsfUBifCB{NTDuUS=> MkXmNlIzPjJzN{G=
HCT116p53(-/-) MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDtUlJTOTBvMUCwNEBvVQ>? MVqyOE81QCCq MlLibY5pcWKrdIOgZ4VtdCCycn;sbYZmemG2aX;uJINwdXCuZYTlcJkh[XRiMkWgcm0> NIf2OWwzOjJ4MkG3NS=>
HeLa  NXvabWFXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGr6UlgyOC1zMECgcm0> MVe0PEBp NGDGO3FFVVOR M3TCfWlEPTB;NUKuPUBvVQ>? NEGyUlIzOjB6MEKzOS=>
HeLa  MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnG3NVAuOTByIH7N M1fGPVczKGh? MXvEUXNQ M3\oRWlEPTB;NUCuOUBvVQ>? M4rFXVIzODhyMkO1
GBC NXzPcVVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPL[XA1PzJiaB?= M{\0XmlEPTB;MUSuO|ghdk1? M1u2XFIyQTZ3N{O5
GB-CL-1 MkTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvRb2E4OiCq Ml\wTWM2OD13LkKyJI5O NH\TR4IzOTl4NUezPS=>
Mz-ChA-2 M{jKR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUe3NkBp M3u3[mlEPTB;Mz6zNUBvVQ>? M3v5fVIyQTZ3N{O5
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EGI-1 M3vydWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLpWYNTPzJiaB?= M2Dwb2lEPTB;MUCuO|Ihdk1? NIWyWW4zOTl4NUezPS=>
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A498 NHvJPY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDtOU05OCCwTR?= NIn5XHA6PiCq Ml33TGNt NYPpeXJ[e3WycILld5NmeyC2aHWgdJJwdGmoZYLheIlwdiCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meiC5aYToJGlEPTEEoI\hcJVmeyCxZjCyJJRwKDJyIH7N M1mzVlIyPjR{M{e0
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Caki-1 M33KSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDTSmJJPS16MDDuUS=> MY[5OkBp NX64eZd3UEOu MV7zeZBxemW|c3XzJJRp\SCycn;sbYZmemG2aX;uJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXyJJdqfGhiSVO1NOKhfmGudXXzJI9nKDJidH:gNlAhdk1? M{fpU|IyPjR{M{e0
SN12C MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXEdGc6PS16MDDuUS=> M3HSN|k3KGh? M3zyOWhEdA>? MY\zeZBxemW|c3XzJJRp\SCycn;sbYZmemG2aX;uJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXyJJdqfGhiSVO1NOKhfmGudXXzJI9nKDJidH:gNlAhdk1? MYGyNVY1OjN5NB?=
HMC-1.1 M3zRW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWCxMVExODBibl2= MYe3NkBp MVjpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoU> NX76U5pmOjF{NEKxPFk>
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C2 NYLFW29lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWKxMVExODBibl2= NXLUR3FVPzJiaB?= MUnpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoU> NILRSHYzOTJ2MkG4PS=>
CHP-212 NY\0ZXIzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vqWlEuOTJ3IH7N MkjzNlQuOTJyIHi= NUTibY8{cW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBjd3SqIITpcYUuKGGwZDDkc5NmNWSncHXu[IVvfCCvYX7u[S=> MmHnNlEyPjl{NEK=
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CAL62 NIf0RYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3r4dVAvOS1zMECgcm0> M4\oPVczKGh? M4f0[GROW09? NGfzU2tGSzVyPUGuOEBvVQ>? NWnqdpJ6OTl{MkO1OVM>
OCUT-1 M1zhTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXSwMlEuOTByIH7N MkGzO|IhcA>? MVjEUXNQ NX3OSFBsTUN3ME2yMlMhdk1? NX7Q[olHOTl{MkO1OVM>
8505C MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\oeYoxNjFvMUCwJI5O MV23NkBp M17QSmROW09? M{j0OmVEPTB;Mz6yJI5O NYPqN5Q3OTl{MkO1OVM>
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SW1736 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLJNE4yNTFyMDDuUS=> M1XLV|czKGh? M3r0TWROW09? MUnFR|UxRTVwNjDuUS=> MXixPVIzOzV3Mx?=

... Click to View More Cell Line Experimental Data
体内研究 BI 2536静脉注射给药多种移植瘤模型，每周一次或两次，效果都很好，通过使细胞周期停滞而抑制细胞增殖，随后诱导肿瘤细胞死亡。BI 2536按 50 mg/kg剂量处理HCT 116移植瘤，每周一次或两次，显著抑制肿瘤生长，T/C 分别为15%和0.3%。BI 2536每周处理两次BxPC-3和A549模型，也显著抑制肿瘤生长，T/C分别为5% 和14%。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验： [1]
+ 展开

体外Plk1激酶实验:

重组人Plk1 (1-603残基) 作为氮端，携带杆状病毒表达系统的GST-标记的融合蛋白通过亲和层析，使用谷胱甘肽-琼脂糖而纯化。在梯度稀释的BI 2536存在时，使用 20 ng 重组激酶，及10 μg牛奶中的酪蛋白作为底物进行Plk1 酶活性实验。在终体积为60 μL 的混合物(15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP)中30oC下进行激酶反应45分钟。加入 125 μL 冰冻的5% TCA终止反应。沉淀物转移到混合酯纤维素的多屏过滤板上，使用1% TCA冲洗实验板，然后利用放射性进行测量。绘制剂量反应曲线，而计算IC50值。
细胞实验：[1]
+ 展开
  • Cell lines: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji, PC-3,等等
  • Concentrations: 溶于DMSO, 终浓度为~1 μM
  • Incubation Time: 24,和72小时
  • Method: 使用不同浓度BI 2536处理细胞24和72小时。 在荧光分光光度计中测量Alamar Blue染料转换而测定细胞生长。为了测定培养基中DNA含量，细胞悬液在80%乙醇中混合, 使用溶于PBS的0.25% Triton X-100处理5分钟，然后与0.1% RNase 和溶于PBS的 10 μg/mL碘化丙啶在室温下温育20分钟。通过流式细胞仪分析而测定细胞周期谱。
    (Only for Reference)
动物实验：[1]
+ 展开
  • Animal Models: 皮下注射HCT 116, NCI-H460, 或A549 细胞的雌性BomTac:NMRI-Foxn1nu 小鼠
  • Formulation: 在盐酸(0.1 N)中配制，然后在0.9% NaCl中稀释。
  • Dosages: ~50 mg/kg
  • Administration: 静脉注射，每周一到两次
    (Only for Reference)

溶解度 (25°C)

体外 Ethanol 100 mg/mL (191.69 mM)
DMSO 21 mg/mL (40.25 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)：
30% PEG 400+0.5% Tween 80+5% Propylene glycol 		15mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 521.66
化学式

C28H39N7O3
CAS号 755038-02-9
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量：

总分子量：g/mol

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00526149 Completed Breast Cancer|Endometrial Cancer|Head and Neck Cancer|Melanoma (Skin)|Ovarian Cancer|Sarcoma European Organisation for Research and Treatment of Cancer - EORTC July 2007 Phase 2
NCT02215044 Terminated Pancreatic Neoplasms Boehringer Ingelheim June 2007 Phase 1
NCT00412880 Completed Carcinoma Small Cell Boehringer Ingelheim January 2007 Phase 2
NCT02211833 Completed Carcinoma Non-Small-Cell Lung Boehringer Ingelheim October 2006 Phase 1
NCT00701766 Completed Leukemia Myeloid Acute Boehringer Ingelheim October 2006 Phase 2
NCT00706498 Completed Prostatic Neoplasms Boehringer Ingelheim September 2006 Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1：

    We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?

  • 回答：

    For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

Selleck产品目录册

PLK Signaling Pathway Map

PLK Inhibitors with Unique Features

  • 选择性强的Plk抑制剂

    GSK461364 : Plk1-selective, Ki=2.2 nM.

  • 用于临床的Plk抑制剂

    Rigosertib (ON-01910) : Phase III for Myelo Dysplastic Syndrome (MDS).

  • 最新的Plk抑制剂

    Ro3280 New : Potent, highly selective inhibitor of Polo-like kinase 1 (PLK1) with IC50 of 3 nM.

  • 经典的Plk抑制剂

    Volasertib (BI 6727) : Highly potent Plk1 inhibitor with IC50 of 0.87 nM and in phase II trials.

相关PLK产品

  • SBE 13 HCl New

    SBE 13 HCl是一种有效的选择性PLK1抑制剂，IC50为200 pM，选择性比 Aurora A 激酶, Plk2 和 Plk3高4000多倍。

  • Ro-3306 New

    RO-3306是一种ATP竞争性的选择性 CDK1 抑制剂，Ki 为20 nM，选择性是其他各种人类激酶的15倍多。

  • CCG-1423 New

    CCG-1423是一种特定的 RhoA 通路抑制剂，能够抑制SRF介导的转录。

  • Rigosertib (ON-01910)

    Rigosertib (ON-01910)是一种非ATP竞争性PLK1抑制剂，无细胞试验中IC50为9 nM，比作用于Plk2选择性高30倍，对Plk3没有抑制活性。Phase 3。

    Features:Rigosertib是作用于Polo样激酶（PLK1）的非ATP竞争性抑制剂。

  • HMN-214

    HMN-214是HMN-176的前体药物，改变了Plk1的细胞空间定位。

    Features:HMN-214 是HMN-176的口服药物前体， 是口服有效的Polo样激酶(Plk)1 抑制剂。

  • GSK461364

    GSK461364抑制纯化的Plk1，无细胞试验中Ki为2 nM。比作用于Plk2/3选择性高1000倍。Phase 1。

    Features:GSK461364是有效的，可逆的ATP竞争性的Plk1选择性抑制剂，作用于Plk1比作用于Plk2和Plk3选择性至少高390倍，而比作用于一组48种其他激酶选择性高1×103倍。

  • Volasertib (BI 6727)

    Volasertib (BI 6727)是一种高度有效的Plk1抑制剂，无细胞试验中IC50为0.87 nM，比作用于Plk2和Plk3选择性高6和65倍。Phase 3。

    Features:BI6727具有高的体积分布，良好的组织穿透力和长的半衰期。

  • MLN0905

    MLN0905是一种有效的PLK1抑制剂，IC50为2 nM。

  • Ro3280

    Ro3280是一种有效的，高选择性Polo-like kinase 1(PLK1)抑制剂，IC50为3 nM。

  • NMS-P937 (NMS1286937)

    NMS-P937（NMS1286937）是一种口服有效的，选择性Polo-like Kinase 1 (PLK1)抑制剂有,其IC50为2 nM，比PLK2/PLK3高出5000倍的选择性。第1阶段。

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID