S3I-201

For research use only. Not for use in humans.

目录号：S1155 别名： NSC 74859

CAS No. 501919-59-1

S3I-201 (NSC 74859) 有效抑制STAT3的DNA结合活性，IC50为86 μM，而对STAT1和STAT5的抑制活性低。

规格

价格

库存

购买数量

10mM (1mL in DMSO)	RMB 638.93	现货
5mg	RMB 563.02	现货
10mg	RMB 972.36	现货
50mg	RMB 3028.28	现货
200mg	RMB 8165.43	现货
大包装	有超大折扣

大剂量询单有大折扣!

今日订购，明日送达，全国免运费！

全国免费电话：400-668-6834 | Email：info@selleck.cn

客户使用Selleck生产的S3I-201发表文献177篇：

Nat Med, 2018, 24(3):352-359

PubMed: 29400710 ( click the link to review the publication )

Cell, 2017, 168(6):1053-1064

PubMed: 28283061 ( click the link to review the publication )

Cancer Discov, 2013, 3(2):158-67

PubMed: 23242808 ( click the link to review the publication )

Nat Commun, 2021, 12(1):1394

PubMed: 33654093 ( click the link to review the publication )

Cell Rep, 2021, 34(1):108584

PubMed: 33406422 ( click the link to review the publication )

J Exp Clin Cancer Res, 2021, 40(1):274

PubMed: 34465361 ( click the link to review the publication )

PLoS Pathog, 2021, 17(1):e1009091

PubMed: 33411730 ( click the link to review the publication )

Cell Death Dis, 2021, 12(8):761

PubMed: 34341336 ( click the link to review the publication )

J Cell Mol Med, 2021, 10.1111/jcmm.16256

PubMed: 33410581 ( click the link to review the publication )

Biochem Pharmacol, 2021, 190:114600

PubMed: 33992630 ( click the link to review the publication )

Mol Carcinog, 2021, 60(7):481-496

PubMed: 34018249 ( click the link to review the publication )

Am J Physiol Cell Physiol, 2021, 10.1152/ajpcell.00517.2020

PubMed: 34260299 ( click the link to review the publication )

Life Sci, 2021, S0024-3205(21)00933-4

PubMed: 34516993 ( click the link to review the publication )

Phytother Res, 2021, 10.1002/ptr.7117

PubMed: 34038010 ( click the link to review the publication )

Andrology, 2021, 10.1111/andr.13109

PubMed: 34516050 ( click the link to review the publication )

J Biosci Bioeng, 2021, S1389-1723(21)00178-X

PubMed: 34429248 ( click the link to review the publication )

J Ocul Pharmacol Ther, 2021, 37(6):331-337

PubMed: 33999692 ( click the link to review the publication )

Oncol Lett, 2021, 21(2):143

PubMed: 33552262 ( click the link to review the publication )

J Cell Mol Med, 2021, 25(3):1568-1582

PubMed: 33410581 ( click the link to review the publication )

Elife, 2020, 30;9. pii: e51317

PubMed: 32223889 ( click the link to review the publication )

Brain Behav Immun, 2020, 84:72-79

PubMed: 31751616 ( click the link to review the publication )

Cancers (Basel), 2020, 19;12(3) pii: E726

PubMed: 32204484 ( click the link to review the publication )

Cell Death Dis, 2020, 11(10):925

PubMed: 33116117 ( click the link to review the publication )

Aging (Albany NY), 2020, 16;12(8):6611-6629

PubMed: 32298237 ( click the link to review the publication )
J Cancer, 2020, 6;11(13):3725-3735

PubMed: 32328177 ( click the link to review the publication )

J Cell Physiol, 2020, 10.1002/jcp.30236

PubMed: 33368292 ( click the link to review the publication )

J Cell Physiol, 2020, 31

PubMed: 32474927 ( click the link to review the publication )

Int J Mol Sci, 2020, 21(22)E8770

PubMed: 33233528 ( click the link to review the publication )

Front Microbiol, 2020, 11:573844

PubMed: 33324360 ( click the link to review the publication )

Front Pharmacol, 2020, 11:614450

PubMed: 33584292 ( click the link to review the publication )

J Dermatol Sci, 2020, S0923-1811(20)30299-1

PubMed: 33055012 ( click the link to review the publication )

Exp Biol Med (Maywood), 2020, 245(7):654-666

PubMed: 32075431 ( click the link to review the publication )

Biochem Biophys Res Commun, 2020, 21;526(1):253-260

PubMed: 32204916 ( click the link to review the publication )

Immunity, 2020, S1074-7613(20)30278-8

PubMed: 32673566 ( click the link to review the publication )

FASEB J, 2020, 10.1096/fj.202000080RR

PubMed: 32645243 ( click the link to review the publication )

Front Immunol, 2020, 11:414

PubMed: 32210977 ( click the link to review the publication )

Elife, 2020, 9:e53367

PubMed: 32513387 ( click the link to review the publication )

Int J Biol Macromol, 2020, 147:616-628

PubMed: 31931060 ( click the link to review the publication )

Mol Vis, 2020, 26:517-529

PubMed: 32818015 ( click the link to review the publication )

Cell Oncol (Dordr), 2020, 10.1007/s13402-020-00532-6

PubMed: 32729021 ( click the link to review the publication )

J Immunol, 2020, 204(9):2589-2599

PubMed: 32198140 ( click the link to review the publication )

JCI Insight, 2020, 137528

PubMed: 33119551 ( click the link to review the publication )

J Control Release, 2019, 319:234-245

PubMed: 31899269 ( click the link to review the publication )

Elife, 2019, 8e41159

PubMed: 30735121 ( click the link to review the publication )

Redox Biol, 2019, 24:101189

PubMed: 30986607 ( click the link to review the publication )

Oncogene, 2019, 38(49):7433-7446

PubMed: 31427736 ( click the link to review the publication )

Br J Pharmacol, 2019, 176(22):4388-4401

PubMed: 30270436 ( click the link to review the publication )

Cancers (Basel), 2019, 11(9)

PubMed: 31438567 ( click the link to review the publication )
Cancers (Basel), 2019, 11(10)E1407

PubMed: 31547152 ( click the link to review the publication )

Cancers (Basel), 2019, 11(1)

PubMed: 30634502 ( click the link to review the publication )

PLoS Pathog, 2019, 15(11):e1008037

PubMed: 31725811 ( click the link to review the publication )

Cell Death Dis, 2019, 10(2):104

PubMed: 30718461 ( click the link to review the publication )

Cell Death Dis, 2019, 10(11):848

PubMed: 31699972 ( click the link to review the publication )

Stem Cells, 2019, 37(11):1389-1400

PubMed: 31322782 ( click the link to review the publication )

Front Immunol, 2019, 10:1843

PubMed: 31474976 ( click the link to review the publication )

J Neuroinflammation, 2019, 16(1):29

PubMed: 30736806 ( click the link to review the publication )

J Immunol, 2019, 202(11):3173-3186

PubMed: 30996000 ( click the link to review the publication )

J Cell Physiol, 2019, 234(12):22517-22528

PubMed: 31102288 ( click the link to review the publication )

J Cell Mol Med, 2019, 23(5):3696-3710

PubMed: 30907506 ( click the link to review the publication )

Neuropharmacology, 2019, 144:143-154

PubMed: 30366000 ( click the link to review the publication )

Biochem Pharmacol, 2019, 170:113642

PubMed: 31541631 ( click the link to review the publication )

Sci Rep, 2019, 9(1):3705

PubMed: 30842489 ( click the link to review the publication )

Sci Rep, 2019, 9(1):1897

PubMed: 30760778 ( click the link to review the publication )

Int J Biol Macromol, 2019, 136:980-993

PubMed: 31220493 ( click the link to review the publication )

Gene, 2019, 687:73-81

PubMed: 30391438 ( click the link to review the publication )

Cell Signal, 2019, 53:327-338

PubMed: 30389500 ( click the link to review the publication )

J Cell Biochem, 2019, 120(3):3637-3650

PubMed: 30242894 ( click the link to review the publication )

Invest Ophthalmol Vis Sci, 2019, 60(12):3776-3785

PubMed: 31503282 ( click the link to review the publication )

Prostate, 2019, 79(9):1018-1031

PubMed: 31018021 ( click the link to review the publication )

Exp Cell Res, 2019, 10.1016/j.yexcr.2019.111748

PubMed: 31785228 ( click the link to review the publication )

BMC Cancer, 2019, 19(1):1180

PubMed: 31795965 ( click the link to review the publication )

Cancer Med, 2019, 8(16):7086-7097

PubMed: 31573734 ( click the link to review the publication )
Vet Res, 2019, 50(1):111

PubMed: 31864417 ( click the link to review the publication )

J Diabetes Res, 2019, 2019:5483946

PubMed: 31223625 ( click the link to review the publication )

Immunobiology, 2019, 224(3):388-396

PubMed: 30846331 ( click the link to review the publication )

Am J Reprod Immunol, 2019, 82(2):e13150

PubMed: 31131948 ( click the link to review the publication )

Onco Targets Ther, 2019, 12:8125-8138

PubMed: 31686858 ( click the link to review the publication )

Onco Targets Ther, 2019, 12:933-944

PubMed: 30774379 ( click the link to review the publication )

FEBS Open Bio, 2019, 9(2):335-347

PubMed: 30761258 ( click the link to review the publication )

Cancer Immunol Res, 2019,

PubMed: 31451482 ( click the link to review the publication )

Nat Commun, 2018, 9(1):1352

PubMed: 29636449 ( click the link to review the publication )

Proc Natl Acad Sci U S A, 2018, 115(12):E2801-E2810

PubMed: 29507229 ( click the link to review the publication )

Oncogene, 2018,

PubMed: 29449693 ( click the link to review the publication )

Oncogene, 2018,

PubMed: 29059160 ( click the link to review the publication )

Hypertension, 2018, 72(6):1301-1311

PubMed: 30571233 ( click the link to review the publication )

J Pathol, 2018, 245(1):114-125

PubMed: 29468680 ( click the link to review the publication )

Front Immunol, 2018, 9:240

PubMed: 29483920 ( click the link to review the publication )

J Neuroinflammation, 2018, 15(1):292

PubMed: 30342528 ( click the link to review the publication )

Biochim Biophys Acta Mol Basis Dis, 2018, 1864(11):3824-3836

PubMed: 30251698 ( click the link to review the publication )

Lab Invest, 2018, 98(12):1600-1613

PubMed: 30206312 ( click the link to review the publication )

Biochem Pharmacol, 2018, 150:267-279

PubMed: 29476714 ( click the link to review the publication )

Int J Mol Sci, 2018, 20(1)

PubMed: 30591689 ( click the link to review the publication )

Sci Rep, 2018, 8(1):13638

PubMed: 30206377 ( click the link to review the publication )

J Biol Chem, 2018, 293(28):11143-11153

PubMed: 29853638 ( click the link to review the publication )

Int J Oncol, 2018, 52(6):2143-2154

PubMed: 29620166 ( click the link to review the publication )

J Cell Biochem, 2018, 119(1):300-313

PubMed: 28569433 ( click the link to review the publication )
Neurochem Res, 2018, 43(3):556-565

PubMed: 29313211 ( click the link to review the publication )

PLoS One, 2018, 13(4):e0195864

PubMed: 29652915 ( click the link to review the publication )

Biochem Biophys Res Commun, 2018, 503(1):177-180

PubMed: 29885836 ( click the link to review the publication )

J Oral Pathol Med, 2018, 47(9):823-829

PubMed: 29924888 ( click the link to review the publication )

Tumour Biol, 2018, 40(1):1010428317731369

PubMed: 29320977 ( click the link to review the publication )

JCI Insight, 2018, 3(22)125568

PubMed: 30429379 ( click the link to review the publication )

Nat Commun, 2017, 8(1):1130

PubMed: 29066712 ( click the link to review the publication )

Theranostics, 2017, 7(16):3972-3988

PubMed: 29109792 ( click the link to review the publication )

Oncogene, 2017,

PubMed: 28459461 ( click the link to review the publication )

Cardiovasc Res, 2017, 113(3):310-320

PubMed: 28158495 ( click the link to review the publication )

Pain, 2017, 158(4):637-648

PubMed: 28072604 ( click the link to review the publication )

Cell Physiol Biochem, 2017, 43(6):2379-2390

PubMed: 29073625 ( click the link to review the publication )

J Dent Res, 2017,

PubMed: 28605599 ( click the link to review the publication )

Mol Oncol, 2017, 11(5):552-566

PubMed: 28296140 ( click the link to review the publication )

J Lipid Res, 2017, 58(11):2102-2113

PubMed: 28874440 ( click the link to review the publication )

Exp Neurol, 2017, 296:74-82

PubMed: 28729113 ( click the link to review the publication )

Sci Rep, 2017, 7:45077

PubMed: 28322331 ( click the link to review the publication )

Am J Cancer Res, 2017, 7(3):727-739

PubMed: 28401024 ( click the link to review the publication )

J Cell Biochem, 2017, 118(12):4672-4685

PubMed: 28498494 ( click the link to review the publication )

Mol Pain, 2017, 13:1744806917747425

PubMed: 29166835 ( click the link to review the publication )

Behav Brain Res, 2017, 335:151-157

PubMed: 28827130 ( click the link to review the publication )

Biochem Biophys Res Commun, 2017, 487(4):820-826

PubMed: 28455228 ( click the link to review the publication )

Cell Biol Int, 2017, 41(1):84-92

PubMed: 27778412 ( click the link to review the publication )

JCI Insight, 2017, 2(6):e90196

PubMed: 28352655 ( click the link to review the publication )
Stem Cell Reports, 2017, 9(1):231-246

PubMed: 28669599 ( click the link to review the publication )

Cell, 2017, 168(6):1053-1064

PubMed: 28283061 ( click the link to review the publication )

Hepatology, 2017, 66(6):1934-1951

PubMed: 28714104 ( click the link to review the publication )

Int J Cancer, 2016, 138(2):451-62

PubMed: 26239999 ( click the link to review the publication )

Oncogene, 2016,

PubMed: 26804171 ( click the link to review the publication )

Cancer Lett, 2016,

PubMed: 27431309 ( click the link to review the publication )

Oncoimmunology, 2016, 5(5):e1130206

PubMed: 27467947 ( click the link to review the publication )

Sci Rep, 2016, 6:34740

PubMed: 27734898 ( click the link to review the publication )

Cell Mol Biol Lett, 2016, 21:9

PubMed: 28536612 ( click the link to review the publication )

Am J Transl Res, 2016, 8(8):3387-97

PubMed: 27648129 ( click the link to review the publication )

Cell Biol Int, 2016, 40(2):177-87

PubMed: 26462870 ( click the link to review the publication )

Oncotarget, 2016, 7(19):28435-47

PubMed: 27078846 ( click the link to review the publication )

Oncotarget, 2016, 7(24):36501-36509

PubMed: 27145366 ( click the link to review the publication )

Circ Arrhythm Electrophysiol, 2016, 9(7)

PubMed: 27406600 ( click the link to review the publication )

Gastroenterology, 2015, 148(3):579-89

PubMed: 25461668 ( click the link to review the publication )

Clin Cancer Res, 2015, 10.1158/1078-0432.CCR-15-0016

PubMed: 26019170 ( click the link to review the publication )

mBio, 2015, 6(6):e01499-15

PubMed: 26646010 ( click the link to review the publication )

PLoS Genet, 2015, 11(12):e1005734

PubMed: 26678048 ( click the link to review the publication )

J Antimicrob Chemother, 2015, 10.1093/jac/dkv077

PubMed: 25858355 ( click the link to review the publication )

Am J Cancer Res, 2015, 5(5):1751-61

PubMed: 26175943 ( click the link to review the publication )

Int J Oncol, 2015, 46(5):2083-95

PubMed: 25695284 ( click the link to review the publication )

World J Gastroenterol, 2015, 21(14):4216-24

PubMed: 25892871 ( click the link to review the publication )

Oncol Rep, 2015, 34(4):1875-82

PubMed: 26238612 ( click the link to review the publication )

Biochem Biophys Res Commun, 2015, 10.1016/j.bbrc.2015.02.114

PubMed: 25735977 ( click the link to review the publication )
Biochem Biophys Res Commun, 2015, 10.1016/j.bbrc.2015.02.027

PubMed: 25701777 ( click the link to review the publication )

J Geriatr Cardiol, 2015, 12(6):591-9

PubMed: 26788034 ( click the link to review the publication )

Mol Med Rep, 2015, 12(1):498-502

PubMed: 25760445 ( click the link to review the publication )

Cancer Immunol Res, 2015,

PubMed: 25968456 ( click the link to review the publication )

Oncotarget, 2015, 6(11):8900-13

PubMed: 25823926 ( click the link to review the publication )

Tumour Biol, 2015, 36(2):973-81

PubMed: ( click the link to review the publication )

Oncotarget, 2015,

PubMed: 26556875 ( click the link to review the publication )

Tumour Biol, 2015, 36(12):9723-32

PubMed: 26156799 ( click the link to review the publication )

JAKSTAT, 2015,

PubMed: 27217982 ( click the link to review the publication )

Oncotarget, 2015,

PubMed: 26561201 ( click the link to review the publication )

Tumour Biol, 2015, 36(2):973-81

PubMed: 25318604 ( click the link to review the publication )

Mol Cancer, 2014, 13:176

PubMed: 25047660 ( click the link to review the publication )

Sci Signal, 2014, 7(322):ra38

PubMed: 24757178 ( click the link to review the publication )

J Immunol, 2014, 192(8):3470-3

PubMed: 24639346 ( click the link to review the publication )

J Virol, 2014, 88(19):11045-55

PubMed: 25008924 ( click the link to review the publication )

Cell Signal, 2014, 27(2):293-305

PubMed: 25446253 ( click the link to review the publication )

Int Immunopharmacol, 2014, 20(1):117-23

PubMed: 24606770 ( click the link to review the publication )

Microbes Infect, 2014, 16(1):17-27

PubMed: 24140557 ( click the link to review the publication )

Biomed Res Int, 2014, 764981

PubMed: 25057499 ( click the link to review the publication )

Biochem Biophys Res Commun, 2014, 10.1016/j.bbrc.2014.09.129

PubMed: 25285632 ( click the link to review the publication )

Biochem Insights, 2014, 7:1-13

PubMed: 25452693 ( click the link to review the publication )

Toxicol Rep, 2014, 10.1016/j.toxrep.2014.10.018

PubMed: ( click the link to review the publication )

Toxicol Rep, 2014, 1:1087-1095

PubMed: 28962320 ( click the link to review the publication )

Tumour Biol, 2014, 35(10):9759-67

PubMed: 24972969 ( click the link to review the publication )
Biochem Insights, 2014, 7:1-13

PubMed: 25452693 ( click the link to review the publication )

Tumour Biol, 2014, 35(10):9793-9

PubMed: 24981247 ( click the link to review the publication )

Arthritis Rheum, 2013, 65(2):481-91

PubMed: 23045159 ( click the link to review the publication )

Carcinogenesis, 2013, 34(9):1994-9

PubMed: 23677069 ( click the link to review the publication )

Cancer Sci, 2013, 104(8):1027-32

PubMed: 23710822 ( click the link to review the publication )

J Biol Chem, 2013, 288(36):26167-76

PubMed: 23902772 ( click the link to review the publication )

Mol Endocrinol, 2013, 27(10):1617-31

PubMed: 23893956 ( click the link to review the publication )

Int J Cancer, 2012, 131(12):2774-84

PubMed: 22488367 ( click the link to review the publication )

Mol Cancer, 2011, 10:66

PubMed: 21619683 ( click the link to review the publication )

产品安全说明书

STAT抑制剂选择性比较

生物活性

产品描述

S3I-201 (NSC 74859) 有效抑制STAT3的DNA结合活性，IC50为86 μM，而对STAT1和STAT5的抑制活性低。

特性

S3I-201是化学探测器抑制剂，可以除去乳腺瘤。

靶点

STAT3 ^[1]
(Cell-free assay)

86 μM

体外研究

S3I-201选择性抑制Stat3 DNA结合活性。S3I-201抑制Stat3·Stat3复合形式,不依赖于Stat3的激活状态。S3I-201不干涉Lck SH2与同源pTyr肽结合。S3I-201作用于NIH 3T3/v-Src鼠成纤维细胞和人类乳腺癌MDA-MB-231, MDA-MB-435, 和MDA-MB-468 细胞，可以抑制Stat3激活。S3I-201 抑制Stat3依赖的转录活性。 S3I-201 也抑制编码cyclin D1, Bcl-xL,和surviving 的Stat3-调节基因的表达。^[1]S3I-201可以降低 pS727STAT3水平和降低TGF-β通路蛋白水平。S3I-201也可抑制CD133+ 和CD133− Huh-7细胞。^[2]最新研究显示S3I-201作用于Hep-G2, Huh-7和SK-HEP-1细胞，加强 Cetuximab的抗增殖效果。^[3]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
U87	Ml6zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		M{DaN\|czKGh?		MWHJR\|UxRTV3LkGg{txO	NVj6SnlPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCwO\|I3PTJpPkKwNFczPjV{PD;hQi=>
U373	NXnoW2JMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MkWxO\|IhcA>?		MVLJR\|UxRTV{LkWg{txO	MlW4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjByN{K2OVIoRjJyMEeyOlUzRC:jPh?=
HPAC	M3\3bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		M{C1Z\|czKGh?		NUHKVFJXUUN3MP-8olExOCEQvF2=	NFK5XVc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEC3NlY2Oid-MkCwO\|I3PTJ:L3G+
PANC-1	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NX\VS\|F5PzJiaB?=		NWPpSI5nUUN3MP-8olExOCEQvF2=	NI\iSZI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEC3NlY2Oid-MkCwO\|I3PTJ:L3G+
SK-BR-3	MljuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MnPiO\|IhcA>?		MWXJR\|Ux97zgMUCwJO69VQ>?	MmC0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjByN{K2OVIoRjJyMEeyOlUzRC:jPh?=
U-373 MG	NV;Ic4I2S3m2b4TvfIlkcXS7IFHzd4F6	M1jTb\|MwOTBizszN	Mmf6NlQhcA>?		M1vxOJJm\HWlZYOgSm4u\|rNvaX7keYNm\CClZXzsJI5mfXKxdH;4bYNqfHl?	M2jVRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOEi4OFE3Lz5{MEi4PFQyPjxxYU6=
MDA-MB-231	M2HyS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MnfuO\|IhcA>?		MXzJR\|Ux97zgMUCwJO69VQ>?	NYTOXZBiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCwO\|I3PTJpPkKwNFczPjV{PD;hQi=>
HUVEC	NUnUS2dPTnWwY4Tpc44hSXO\|YYm=	M4K4PVAvPS1{MDFOwG0>	M{HBbVI1KGh?	MmXYSG1UVw>?	M4\OcpN2eHC{ZYPz[ZMhfGinIHj5dI95cWFvaX7keYNm\CCjY3P1cZVt[XSrb36gc4YhUEmILUJOtS=>	MkfuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3MkO1OVkoRjJzNUKzOVU6RC:jPh?=
Huh7	NGjEe2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NX\ZU2tPOTByIH7N	M1G5bFQ5KGh?	MXfEUXNQ	MkO4bY5pcWKrdIOgeIhmKEmOLU[gd5RqdXWuYYTpc44heHKxbX;0[YQh[2WubDDwdo9tcW[ncnH0bY9v	NFHzRZA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{O2OFM5QSd-MkOzOlQ{QDl:L3G+
PLC/PRF/5	Mli3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUexNFAhdk1?	MmTTOFghcA>?	NEnlUJJFVVOR	NI\qO2NqdmirYnn0d{B1cGViSVytOkB{fGmvdXzheIlwdiCycn;tc5Rm\CClZXzsJJBzd2yrZnXyZZRqd25?	NF3SdFE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{O2OFM5QSd-MkOzOlQ{QDl:L3G+
H460	MoHkSpVv[3Srb36gRZN{[Xl?	M{nJT\|UxNzFyMDFOwG0>	NH2wN5c1QCCq		NFPETY1qdmirYnn0d{B1cGViU4TheFNEKGmwY4LlZZNm\CCvaWKtPVJiKGW6cILld5Nqd25?	NIrMNIo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{iyNFI2PCd-MkO4NlAzPTR:L3G+
H1299	MofUSpVv[3Srb36gRZN{[Xl?	M4\MZlUxNzFyMDFOwG0>	M1P2W\|Q5KGh?		Mmn3d5VxeHKnc4Pld{BucVJvOULhJIV5eHKnc4Ppc44h\G:\|ZT3k[ZBmdmSnboTsfS=>	NYPLV3VWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4NlAzPTRpPkKzPFIxOjV2PD;hQi=>
T-cell	NEfIUGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVnJR\|UxRTVyIN88US=>	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB4OEezNUc,OjRyNki3N\|E9N2F-
U373	M1zYOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NETQOGIyOjVizszN	NHfqclYzPCCq	NVvEToc6TE2VTx?=	NEH5flFlcXO{dYD0d{BUXEGWMzDzbYdv[WyrbnegZY5lKHC{b3zp[oVz[XSrb36=	M17ofFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEewPFIxLz5{NEC3NFgzODxxYU6=
HUT-102	M4K5fmFxd3C2b4Ppd{BCe3OjeR?=	MXq3OU0{ODBizszN	NHT2cYUzPC92ODDo		MmG4d5VxeHKnc4Pld{Bk\WyuIIDyc4xq\mW{YYTpc44hcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZIh[W6mIHnu[JVk\XNiY3XscEBieG:ydH;zbZPDqA>?	NH\oN5E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC5NFk6PSd-MkSwPVA6QTV:L3G+
MT-2	MXnBdI9xfG:\|aYOgRZN{[Xl?	NHzpN3c4PS1\|MECg{txO	NEXBdY8zPC92ODDo		NU[wfWo5e3WycILld5NmeyClZXzsJJBzd2yrZnXyZZRqd25iaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJiYX7kJIlv\HWlZYOgZ4VtdCCjcH;weI9{cXQEoB?=	NYDScpN2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwPVA6QTVpPkK0NFkxQTl3PD;hQi=>
H460	M1f5WGFxd3C2b4Ppd{BCe3OjeR?=	MVuxNFDDqG6P	NH;tZlAzPMLiaB?=		MmjR[Y5p[W6lZYOgZ4VtdCCmZXH0bEBkdy22cnXheIVlKHerdHigUHkzQTRyMEK=	NHHnSoI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NES3NlU{QCd-MkS0O\|I2Ozh:L3G+
A459	Ml3pRZBweHSxc3nzJGF{e2G7	NF;wfVkyODEEoH7N	MYWyOOKhcA>?		MWPpcoR2[2W\|IHPlcIwh[XCxcITvd4l{KGOxLYTy[YF1\WRid3n0bEBDTVp{M{W=	M1S0UVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEeyOVM5Lz5{NES3NlU{QDxxYU6=
H460	NWruVld{SXCxcITvd4l{KEG\|c3H5	M2\uSlExOMLibl2=	MlrTNlTDqGh?		M1TUfIlv\HWlZYOgZ4VtdCCjcH;weI9{cXNiY3:teJJm[XSnZDD3bZRpKEKHWkKzOS=>	NWLPdoVQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS0O\|I2OzhpPkK0OFczPTN6PD;hQi=>
GC	NWrvXIZiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2DyO\|UxNTF{NTFOwG0>	NXvLelFGPzJiaB?=		MYfheJRmdnWjdHXzJJRp\SClZXzsJIdzd3e2aDDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?=	NFm0SZE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe3OFUxOyd-MkW3O\|Q2ODN:L3G+
GH3	MkDuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWXCbmVPPTBvMUK1JO69VQ>?	MWe3NkBp		MWPheJRmdnWjdHXzJJRp\SClZXzsJIdzd3e2aDDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?=	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd5NEWwN{c,OjV5N{S1NFM9N2F-
BT474R	M2PCfGZ2dmO2aX;uJGF{e2G7	NWWx[5NnPTBizszN	NH3a[5gyOC14MDDk		M2fmR4lvcGmkaYTzJHNVSVR\|IHHjeIl3cXS7	M1vMUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3M{K3OVYyLz5{NUOyO\|U3OTxxYU6=
NCI-N87R	NITkc5dHfW6ldHnvckBCe3OjeR?=	NXTqXnZxPTBizszN	MXOxNE03OCCm		NGW5[XhqdmirYnn0d{BUXEGWMzDhZ5Rqfmm2eR?=	NXPxTG96RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWzNlc2PjFpPkK1N\|I4PTZzPD;hQi=>
MDA-MB-468	NHTwZo9HfW6ldHnvckBie3OjeR?=	NGS3R2EyODBidV2=	NHHzOIYzPCCqcoO=		NITrSG5KdmirYnn0bY9vKG:oIGP0ZZQ{KGGldHn2ZZRqd25iaX6gbJVu[W5iTVTBMW1DNTR4ODDj[YxteyCjdDCxNFAhfU1iYX\0[ZIhOjRiaILz	NEfMUGw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{S2N\|A6OCd-MUe0OlMxQTB:L3G+
MDA-MB-435	M2LL[mZ2dmO2aX;uJIF{e2G7	NYe5NFhOOTByIIXN	MWiyOEBpenN?		MUjJcohq[mm2aX;uJI9nKFO2YYSzJIFkfGm4YYTpc44hcW5iaIXtZY4hVUSDLV3CMVQ{PSClZXzsd{BifCBzMECgeW0h[W[2ZYKgNlQhcHK\|	MoPwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2NkOwPVAoRjF5NE[zNFkxRC:jPh?=
MDA-MB-231	NUe1S5Y2TnWwY4Tpc44h[XO\|YYm=	NFT1ZlEyODBidV2=	M2TXXFI1KGi{cx?=		MWnJcohq[mm2aX;uJI9nKFO2YYSzJIFkfGm4YYTpc44hcW5iaIXtZY4hVUSDLV3CMVI{OSClZXzsd{BifCBzMECgeW0h[W[2ZYKgNlQhcHK\|	MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR4M{C5NEc,OTd2NkOwPVA9N2F-
NIH3T3	M3vIRmZ2dmO2aX;uJIF{e2G7	MUGxNFAhfU1?	MXyyOEBpenN?		NWXHdIZFWmWmdXP0bY9vKG:oIIDUfZIuPzB3IGP0ZZQ{KGyndnXsJIlvKHZvU4LjJIV5eHKnc4PpcochdW:3c3WgUmlJO1R\|IHPlcIx{KGG2IEGwNEB2VSCjZoTldkAzPCCqcoO=	MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR4M{C5NEc,OTd2NkOwPVA9N2F-
NIH3T3	M3;uSmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7	MWGxNFAhfU1?	NEL1eGQ1KGSjeYO=		NHfZOo5Iem:5dHigbY5pcWKrdHnvckBw\iCvb4Xz[UBPUUh\|VEOgZ4VtdHNiZYjwdoV{e2mwZzD2MXNz[yCjdDCxNFAhfU1iYX\0[ZIhPCCmYYnzJIJ6KHS{eYDhckBjdHWnIHX4Z4x2e2mxbjDhd5NigQ>?	NYX2c5VYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0OlMxQTBpPkG3OFY{ODlyPD;hQi=>
MDA-MB-435	MYXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?	NXzPe\|FMOTByIIXN	NUPOOJBxPCCmYYnz		M3LC[Wdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG1FSS2PQj20N\|Uh[2WubIOg[ZhxemW\|c3nu[{B3NVO{YzDheEAyODBidV2gZYZ1\XJiNDDkZZl{KGK7IITyfZBidiCkbIXlJIV5[2y3c3nvckBie3OjeR?=	MoG1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2NkOwPVAoRjF5NE[zNFkxRC:jPh?=
MDA-MB-231	NILMXGpIem:5dHigbY5pcWKrdHnvckBie3OjeR?=	NWjZcHg5OTByIIXN	M{XMeFQh\GG7cx?=		NXvHdZJpT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVUSDLV3CMVI{OSClZXzsd{BmgHC{ZYPzbY5oKHZvU4LjJIF1KDFyMDD1UUBi\nSncjC0JIRigXNiYomgeJJ6eGGwIHLseYUh\XilbIXzbY9vKGG\|c3H5	MkDmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2NkOwPVAoRjF5NE[zNFkxRC:jPh?=
MDA-MB-468	MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?	NVvZT5ZDOTByIIXN	NYLKfG9mPCCmYYnz		MXnHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDNSGEuVUJvNE[4JINmdGy\|IHX4dJJme3Orbnegek1UemNiYYSgNVAxKHWPIHHmeIVzKDRiZHH5d{BjgSC2conwZY4h[my3ZTDlfINtfXOrb36gZZN{[Xl?	NEDmPGs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{S2N\|A6OCd-MUe0OlMxQTB:L3G+
NIH3T3	MkO0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?	NFTYeVEyODBidV2=			MWfHdo94fGhiaX7obYJqfGmxbjDv[kBud3W\|ZTDOTWg{XDNiY3XscJMh\XiycnXzd4lv\yC4LWLhd{BifCBzMECgeW0h\m:{IHX2[ZJ6KDNiZHH5d{BjgSC\|b3\0MYFo[XJiY3;sc456NW[xcn3heIlwdiCjc4PhfS=>	NXGzdWoyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0OlMxQTBpPkG3OFY{ODlyPD;hQi=>
MDA-MB-435	NFLabFlCeG:ydH;zbZMh[XO\|YYm=	NIX1ZYU{OCC2bzCxNFAhfU1?	MnvNOFghcHK\|		MW\JcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKE2GQT3NRk01OzViY3XscJMh\XiycnXzd4lv\yCjY4TpeoUhW3SjdEOgZZQhOzBidH:gNVAxKHWPIHHmeIVzKDR6IHjydy=>	M{O2TFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NE[zNFkxLz5zN{S2N\|A6ODxxYU6=
MDA-MB-231	M{jFR2Fxd3C2b4Ppd{Bie3OjeR?=	MnHxNVAxKHWP	NUP3b\|NnOjRiaILz		NXXURZdQWmWmdXP0bY9vKG:oIHHwc5B1d3OrczDpckBUfGG2MzD0doFve2[nY4Tl[EBpfW2jbjDNSGEuVUJvMkOxJINmdGy\|IHH0JFExOCC3TTDh[pRmeiB{NDDodpM>	NETLeXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{S2N\|A6OCd-MUe0OlMxQTB:L3G+
MDA-MB-231	NV7leGx6TnWwY4Tpc44h[XO\|YYm=	MXWxNFAhfU1?	NIPZcHU1QCCqcoO=		NHzqSZpT\WS3Y4Tpc44hd2ZiY4njcIlvKERzIHflcoUh\XiycnXzd4lwdiCrbjDoeY1idiCPRFGtUWIuOjNzIHPlcIx{KGG2IEGwNEB2VSCjZoTldkA1QCCqcoO=	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR4M{C5NEc,OTd2NkOwPVA9N2F-
MDA-MB-231	NVvVfldMSXCxcITvd4l{KGG\|c3H5	Mnn1NVAxKHWP	Mkf3NlQhcHK\|		MnOwTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDTeIF1OyCVSEKg[I9u[WmwIITyZY5{\mWldHXkJIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYYSgNVAxKHWPIHHmeIVzKDJ2IHjydy=>	NYHZdmp{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0OlMxQTBpPkG3OFY{ODlyPD;hQi=>
MDA-MB-231	Mn\lRZBweHSxc3nzJIF{e2G7	NHnRfYUyODBidV2=	M2XvcVI1KGi{cx?=		NVf4XG04UW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBUfGG2M1OgeJJidnOoZXP0[YQhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDheEAyODBidV2gZYZ1\XJiMkSgbJJ{	NX[ydHVnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0OlMxQTBpPkG3OFY{ODlyPD;hQi=>
NIH3T3	NYnlPYt6TnWwY4Tpc44h[XO\|YYm=	NY\UZoRVOTByIIXN	NYfOPWNEPDhiaILz		NEH5WG9T\WS3Y4Tpc44hd2ZiY4njcIlvKERzIHflcoUh\XiycnXzd4lwdiCrbjD2MXNz[yC2cnHud4Zm[3SnZDDtc5V{\SCQSVizWFMh[2WubIOgZZQhOTByIIXNJIFnfGW{IES4JIhzew>?	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR4M{C5NEc,OTd2NkOwPVA9N2F-
NIH3T3	M4jiTGZ2dmO2aX;uJIF{e2G7	NV3WbVVyOTByIIXN	MYG0PEBpenN?		NVnSZlRiWmWmdXP0bY9vKG:oIFLjcE15VCCpZX7lJIV5eHKnc4Ppc44hcW5idj3TdoMhfHKjboPm[YN1\WRibX;1d4UhVkmKM2SzJINmdGy\|IHH0JFExOCC3TTDh[pRmeiB2ODDodpM>	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR4M{C5NEc,OTd2NkOwPVA9N2F-
NIH3T3	MVjGeY5kfGmxbjDhd5NigQ>?	NHHXd2MyODBidV2=	Mn7TOFghcHK\|		NV2xR2dKWmWmdXP0bY9vKG:oIIP1dpZqfmmwIHflcoUh\XiycnXzd4lwdiCrbjD2MXNz[yC2cnHud4Zm[3SnZDDtc5V{\SCQSVizWFMh[2WubIOgZZQhOTByIIXNJIFnfGW{IES4JIhzew>?	NYX6S\|NqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0OlMxQTBpPkG3OFY{ODlyPD;hQi=>
MDA-MB-231	MkThSpVv[3Srb36gZZN{[Xl?	NYfNZmtCOTByIIXN	NF\L[JA1QCCqcoO=		NUPSfWJ2WmWmdXP0bY9vKG:oIFLjcE15VCCpZX7lJIV5eHKnc4Ppc44hcW5iaIXtZY4hVUSDLV3CMVI{OSClZXzsd{BifCBzMECgeW0h[W[2ZYKgOFghcHK\|	M2rlW\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NE[zNFkxLz5zN{S2N\|A6ODxxYU6=
MDA-MB-231	NYGzXXpSTnWwY4Tpc44h[XO\|YYm=	MXexNFAhfU1?	NGfYV2M1QCCqcoO=		MXvS[YR2[3Srb36gc4Yhe3W{dnn2bY4h\2WwZTDlfJBz\XO\|aX;uJIlvKGi3bXHuJG1FSS2PQj2yN\|Eh[2WubIOgZZQhOTByIIXNJIFnfGW{IES4JIhzew>?	MmTtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2NkOwPVAoRjF5NE[zNFkxRC:jPh?=
MDA-MB-231	MlnyRY51cXS3bX;yJIF{e2G7	NIPqRZM2KG2pL3vn	NEXZdmQzKHenZXvz		M3PEcGFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiZYjwdoV{e2mwZzDhZ5RqfmViU4TheFMhgGWwb3fyZYZ1\WRiaX6gcY92e2ViYYSgOUBu\y:tZzygbZYh\m:{IHX2[ZJ6KDNiZHH5d{Bnd3JiMjD3[YVsew>?	NVzBco02RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0OlMxQTBpPkG3OFY{ODlyPD;hQi=>
NIH3T3	MkXZS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?	MmTtNVAxKHWP			MX3Hdo94fGhiaX7obYJqfGmxbjDv[kBud3W\|ZTDOTWg{XDNiY3XscJMh\XiycnXzd4lv\yC4LWPyZ{BifCBzMECgeW0h\m:{IHX2[ZJ6KDNiZHH5d{BjgSC\|b3\0MYFo[XJiY3;sc456NW[xcn3heIlwdiCjc4PhfS=>	MmTJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2NkOwPVAoRjF5NE[zNFkxRC:jPh?=
A673	M{DnUZFJXFNiYYPzZZk>				M3vXXpFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCDNkezJINmdGy\|	Mk\QQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
SK-N-MC	NH7DeoFyUFSVIHHzd4F6				Ml[wdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKFONLV6tUWMh[2WubIO=	NHHNPFE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
NB1643	M{HqNJFJXFNiYYPzZZk>				NIPpVpFyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiTlKxOlQ{KGOnbHzz	NXzDUGlWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
LAN-5	MYTxTHRUKGG\|c3H5				NVLUemZJeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IFzBUk02KGOnbHzz	MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	STAT3 / p-STAT3 / Cyclin D1 / Bcl-2 / Nanog / OCT4 / ALDH1 / CD44; PubMed: 26556875 Oncotarget Western blotting shows S3I-201 treatment decrease Cyclin D1, Bcl2 and self-renewal marker Nanog, OCT4, ALDH1, and CD44 in a dose dependent manner. Data shown are representative of three individual experiments. PD-L1; PubMed: 28605599 J Dent Res The expression level of PD-L1 was measured by Western blotting in a head and neck squamous cell carcinoma cell line (Cal 27 and FaDu), with and without S3I-201. β-Actin was used as the internal protein loading control. PD-L1, programmed death 1 ligand; STAT, signal transducers and activators of transcription; p-STAT3, phosphorylated STAT3.	26556875 28605599
Immunofluorescence	p-STAT3; PubMed: 26556875 Oncotarget Immunoflurosece shows S3I-201 reduce nuclear expression of p-STAT3Tyr705 by confocal microscope. Oct4 / Twist ; PubMed: 27521216 Oncotarget Suppression of Oct4 and Twist expression was shown in TW01 CD44/CD24 co-overexpressed cells and CSCs after S3I-201 treatment. Scale bars indicate 20 μm.	26556875 27521216
Growth inhibition assay	Cell viability; PubMed: 26813676 Blood The STAT3 inhibitor (S3I-201) decreases cellular proliferation in HTLV-I/ATL-lines. Cells were treated with 0, 12.5, 25, or 50 μM S3I-201 or dimethyl sulfoxide (DMSO) for 72 hours. The average growth curve is representative of the percentage of proliferation between S3I-201 and DMSO-treated cells. Each cell line was treated at least twice for standard deviation. 1185 (-IL2) cells were washed in phosphate-buffered saline and resuspended in media without IL2, followed by treatment with S3I-201 for 72 hours.	26813676

体内研究

5 mg/kg剂量的S3I-201作用于携带人类乳腺癌(MDA-MB-231)的鼠时，显示出强抑制效果。^[1]5 mg/kg剂量的S3I-201作用于Huh-7移植瘤，显示出强抗癌活性，没有明显的外部健康改变或者体重减轻症状。^[2]

激酶实验：^[1]	- 合并体外Stat3 DNA结合实验和EMSA分析: 100 mL生物素-e-Ac-EPQpYEEIEL-OH (溶于50 mM Tris/150 mM NaCl, pH 为7.5) 加到链霉亲和素包被的96孔微型板的每孔中，在4^oC下振荡温育过夜。用PBS/Tween-20冲洗板，然后加入2次200 mL BSA-T-PBS (0.2% BSA/0.1% Tween-20/PBS)。50 mL Lck-SH2-GST 融合蛋白(6.4 ng/ml，溶于BSA-T-PBS中)加到96孔板的每孔中，在室温下振荡处理4小时。转移溶液，用200 mL BSA-T-PBS冲洗4次,然后在每孔中加入100 mL多克隆GST抗体 (100 ng/mL，溶于BSA-T-PBS)，4^oC下温育过夜。用BSA-T-PBS冲洗后, 在每孔中加入100 mL 200 ng/ml BSA-T-PBS辣根过氧化物酶结合的二抗，然后在室温下温育45分钟。用BSA-T-PBS冲洗4步后，再用PBS-T冲洗3步，然后在每孔中加入100 mL过氧化物酶底物，温育5到15分钟。加入100 mL 1 M硫酸溶液终止过氧化物酶反应，使用ELISA计数板在450nm 处读取吸光值。
细胞实验：^[2]	- 合并 Cell lines: HCC细胞系包括HepG2, PLC/PRF/5, SNU-449, Huh-7, SNU-398, SNU-182，和SNU-475 Concentrations: 25到250 μM Incubation Time: 72小时 Method: 5 ×10³个细胞接种在含完全培养基的96孔微型板上。培养72小时后，每孔加入100 μL 2 mg/mL MTT溶液测量存活细胞数。2小时后，转移培养基，每孔加入100 μL二甲亚砜溶解甲结晶。使用酶联免疫吸附法计数器在590 nm处读取吸光值。 (Only for Reference)
动物实验：^[1]	- 合并 Animal Models: 6周大的携带MDA-MB-231移植瘤模型的雌性无胸腺裸鼠 Dosages: 5 mg/kg Administration: 静脉注射，每周2天或3天。 (Only for Reference)

参考文献

[4] Sen N, et al. Proc Natl Acad Sci U S A, 2012, 109(2), 600-605.

- 合并

溶解度 (25°C)

体外	DMSO	73 mg/mL (199.8 mM)
	Water	Insoluble
	Ethanol	Insoluble
体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： 5% DMSO+corn oil	3mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download S3I-201 SDF

分子量	365.36
化学式	C₁₆H₁₅NO₇S
CAS号	501919-59-1
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	NSC 74859

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

研究领域

产品类型

定制您的化合物库

S3I-201

客户使用Selleck生产的S3I-201发表文献177篇：

产品安全说明书

STAT抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download S3I-201 SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

技术支持

STAT Signaling Pathway Map

相关STAT产品