Stattic

For research use only. Not for use in humans.

目录号:S7024

Stattic Chemical Structure

CAS No. 19983-44-9

Stattic 是第一个非肽类STAT3小分子抑制剂,有效抑制STAT3激活和核易位,IC50为5.1 μM,其作用于STAT3的选择性远高于STAT1。Stattic 可诱导凋亡。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 730.64 现货
RMB 901.23 现货
RMB 1392.12 现货
RMB 2375.1 现货
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客户使用Selleck生产的Stattic发表文献153篇:

产品安全说明书

STAT抑制剂选择性比较

生物活性

产品描述 Stattic 是第一个非肽类STAT3小分子抑制剂,有效抑制STAT3激活和核易位,IC50为5.1 μM,其作用于STAT3的选择性远高于STAT1。Stattic 可诱导凋亡。
特性 Stattic是第一个非肽类小分子,抑制STAT3 SH2结构域的功能,无论在体外STAT3磷酸化状态。
靶点
STAT3 [1]
(Cell-free assay)
5.1 μM
体外研究

Stattic抑制gp130受体衍生的含磷酸化酪氨酸的肽结合到STAT3 SH2结构域,这种作用存在强烈的温度依赖性。Stattic对酪氨酸磷酸化的肽结合到酪氨酸激酶Lck的SH2结构域只有很微弱的作用效果。Stattic不抑制其他两个二聚体转录因子(c-Myc/Max 和 Jun/Jun)的二聚化。Stattic抑制荧光素标记的磷酸化肽段结合到STAT1和STAT5b的SH2域。Stattic浓度为10 μM,选择性抑制DNA与STAT3二聚体结合。Stattic抑制STAT3在Tyr705位点磷酸化,而对STAT1在Tyr701(HepG2细胞)位点磷酸化或 JAK1, JAK2, 和c-Src(MDA-MB-231和MDA-MB-235S细胞)磷酸化几乎没有抑制效果。Stattic增加STAT3依赖性的乳腺癌细胞系的凋亡率。[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
H9c2 MWjGeY5kfGmxbjDBd5NigQ>? Ml3INVDjiIoQvF2= NHvUNGc16oDLaB?= MWny[ZZmenOnczD0bIUh\W[oZXP0d{Bw\iCLTD2yOy=> MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjN|OU[zN{c,OjZ|M{m2N|M9N2F-
NPC  NVz4OJB5TnWwY4Tpc44hSXO|YYm= M{PZd|AuPy53INM1US=> MVHhZo9tcXOqZYOgSW1VNWyra3WgcY9t\WO3bHHyJIFtfGW{YYTpc45{NCCjbnSgZ4VtdCCvaXfyZZRqd25iYX7kJIlvfmG|aX;uJIlv\HWlZXSgZpkhWkuLUDDrco9kc2Sxd36= MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTlzNUSzNEc,OjV7MUW0N|A9N2F-
HASMC NXK0RXJqTnWwY4Tpc44hSXO|YYm= NHjoWFEyNjJ3LUWg{txO MXmyNEBucW5? NIPJ[IZFVVORwrC= M4nzTolvcGmkaYTzJJAuMFlrLWPURXQuOSx|LEWgd4lodmGuc9Mg MoS5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6NEm2NlIoRjJ3OES5OlIzRC:jPh?=
H9c2  MlL5SpVv[3Srb36gRZN{[Xl? NXTiXmhGOi9zMDFOwG0> M{LTOFIhcA>? NXPvOottTE2VT9Mg MY\hZpJw\2G2ZYRCpJRp\SCleYTvdJJwfGWldHn2[UBm\m[nY4TzJI9nKEmOLUK3JIFo[Wmwc4SgV2g> NYrseoF7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4NlA6ODdpPkK1PFIxQTB5PD;hQi=>
A431 M3XT[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUT5bYVGOsLizszN NGrPUG4zyqCq NF;q[lhjdG:la4OgSWdHNXKndnXyd4VlKGSnY4LlZZNmeyCrbjDj[YxtKH[rYXLpcIl1gQ>? M1rSW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{KwOFM2Lz5{NUeyNFQ{PTxxYU6=
A431 MmXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVW3eZdROsLizszN MWCyxsBp M3HFb4lv[3KnYYPld{BqdiCjcH;weI9{cXNiaX7keYNm\CCkeTDzbIlsd26rbh?= NGTYdFk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUeyNFQ{PSd-MkW3NlA1OzV:L3G+
SiHa MonaR4VtdCCYaXHibYxqfHliQYPzZZk> MXy1MVc2KG6P NHTN[nczPMLiaNMg MlXjd4hwf3NibX;ydIhwdG:peTDv[kBiKHS7cHnjZYwh[XCxcITveIlkKGOnbHygZY5lKGSxc3Wt[IVx\W6mZX70JIxwe3Nib3[gZ4VtdCC4aXHibYxqfHoEoB?= NU\wc3BLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW1N|k3PDRpPkK1OVM6PjR2PD;hQi=>
SiHa NV65bGt1TnWwY4Tpc44hSXO|YYm= M2fQW|UuPzVibl2= NXzjZ3lqOjUEoHlCpC=> MYPy[YR2[2W|IITo[eKheGixc4Doc5J6dGG2aX;uJIF1KHSqZTD0fZJwe2mwZTDy[ZNq\HWnIEewOeKh MoLFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3M{m2OFQoRjJ3NUO5OlQ1RC:jPh?=
ECA109 M2PRd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XV[|AuOjBizszN MoT2NlTDqGkEoB?= NVi1OYlsUUN3ME21MlUxKM7:TR?= NV3NR|gyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW0PVI1QDBpPkK1OFkzPDhyPD;hQi=>
TE13 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWewMVIxKM7:TR?= NYfnZXRDOjUEoHlCpC=> M13NfGlEPTB;Nj6xOeKh|ryP MkC5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2OUK0PFAoRjJ3NEmyOFgxRC:jPh?=
KYSE150  M{LHO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUSwMVIxKM7:TR?= NVPwco0xOjUEoHlCpC=> MnTrTWM2OD1zMj62OOKh|ryP NFrlT5Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUS5NlQ5OCd-MkW0PVI1QDB:L3G+
ECA109 M3jSbWNtd26xZ3XubYMhW3W{dnn2ZYwhSXO|YYm= NYr3Zpc6OC53wrFOwG0> NYj0TY1OOjUEoHlCpC=> MVnzeZBxemW|c3XzJJRp\SClbH;uc4dmdmmlIH\vdo1ifGmxbh?= MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR7MkS4NEc,OjV2OUK0PFA9N2F-
TE13 MoTDR4xwdm:pZX7pZ{BUfXK4aY\hcEBCe3OjeR?= NIDjSVYxNjYEoN88US=> MVWyOOKhcMLi M2L2bpN2eHC{ZYPz[ZMhfGinIHPsc45w\2WwaXOg[o9zdWG2aX;u M{P5XlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NEmyOFgxLz5{NUS5NlQ5ODxxYU6=
KYSE150  MlTER4xwdm:pZX7pZ{BUfXK4aY\hcEBCe3OjeR?= NGi5SIgxNjYEoN88US=> NFHsfGMzPMLiaNMg NW\kW|B7e3WycILld5NmeyC2aHWgZ4xwdm:pZX7pZ{Bnd3KvYYTpc44> Ml;5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2OUK0PFAoRjJ3NEmyOFgxRC:jPh?=
ECA109 NGLP[lNHfW6ldHnvckBCe3OjeR?= NVXJUXdbOC53wrFOwG0> NUnsOGtvOjUEoHlCpC=> MVPlcohidmOnczDJVk1qdmS3Y3XkJIdmdmW{YYTpc44hd2ZiRGPCdy=> M3;iV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NEmyOFgxLz5{NUS5NlQ5ODxxYU6=
PC3M-1E8 MVfGeY5kfGmxbjDBd5NigQ>? MkfGNk42NzVxMUCg{txO M1ewdlAuPCCq NHXNWIJqdmirYnn0d{B1cGViU2TBWFMh[WO2aY\heIlwdiCrbjDhJIRwe2VvIHHu[EB1cW2nLXTldIVv\GWwdDDtZY5v\XMEoB?= M2i5c|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Mk[xN|Y2Lz5{NUK2NVM3PTxxYU6=
PC3M-1E8 NFi3UXBHfW6ldHnvckBCe3OjeR?= NEPvfYwyOCEQvF2= MUmyOEBp Mnvl[I94dnKnZ4XsZZRmeyCEY3ytfGwtKHO3co\peolvKGGwZDDjMW16[w>? M33yTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Mk[xN|Y2Lz5{NUK2NVM3PTxxYU6=
PC3M-1E8 MnPLSpVv[3Srb36gRZN{[Xl? NWn6SWRZOTBizszN M2\zR|I1KGh? NGSwTINqdmirYnn0d{BKVC14IHnu[JVk\WRiU2TBWFMh[WO2aY\heIlwdiCjbnSgeIhmKEmOLU[tbY5lfWOnZDDTWGFVOyCjY4TpeoF1cW:w MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTJ4MUO2OUc,OjV{NkGzOlU9N2F-
PC3M-1E8 MU\DcI9vd2enbnnjJHN2en[rdnHsJGF{e2G7 Mk\ZNk42NzVxMUCg{txO NWrrd3N[cW6qaXLpeJPDqHSqZTDjc4xwdnliZn;ycYF1cW:wIIPp[45q\mmlYX70cJk> MoTRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{NkGzOlUoRjJ3Mk[xN|Y2RC:jPh?=
MDA-MB-231 NFXUWGVHfW6ldHnvckBCe3OjeR?= MornNlAh|ryP NFHqXVczKGh? M1PPXoV5cGmkaYTzJHNv[WmuIHHu[EBGNWOjZHjldolvKGW6cILld5Nqd25? MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTF3M{O0PUc,OjVzNUOzOFk9N2F-
H9c2 M2[1e2Z2dmO2aX;uJGF{e2G7 NIj5elMzOCEEtV2= MmTPN|AhdWmw NGiwSFBFVVORwrC= NEO4UYNi[m:uaYPo[ZMheHKxcH;mc4wucW6mdXPl[EBCU1RicHjvd5Bpd3K7bHH0bY9vKGG2IHLveIghe2W{NEezJIFv\CC2aIKzNFg> NFewSXA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUGwOVA3Pyd-MkWxNFUxPjd:L3G+
HaCaT  MonuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlz5NVAhyrWP NY\NRXBCOjBibXnu NIHIPJJFVVORwrC= MY\lcohidmOnczDzc5Ji\mWwaXKtJIFv\CC|dX7peIlvcWJvaX7keYNm\CCpcn;3eIghcW6qaXLpeIlwdg>? MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTBzM{mwO{c,OjVyMUO5NFc9N2F-
Caki-1 M2H1cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\2NVAhyrWP M4rUb|IxKG2rbh?= MmHmSG1UV8Li NHPXbmVmdmijbnPld{B{d3KjZnXubYIuKGGwZDDzeY5qfGmwaXKtbY5lfWOnZDDndo94fGhiaX7obYJqfGmxbh?= Ml6wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyMUO5NFcoRjJ3MEGzPVA4RC:jPh?=
HaCaT  MY\BdI9xfG:|aYOgRZN{[Xl? NFHvTlEyOCEEtV2= MkDxNlAhdWmw NWDHeIQ1TE2VT9Mg MmLjbY5kemWjc3XzJJBzd3CxcoTpc45{KG:oIHHwc5B1d3SrYzDj[YxteyCmdXWgeI8hfHKnYYTt[Y51KHerdHigd49z[W[nbnniJI9zKHO3bnn0bY5q[g>? MmG2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyMUO5NFcoRjJ3MEGzPVA4RC:jPh?=
FHL-primed hNSCs M3nEUWNmdGxiVnnhZoltcXS7IFHzd4F6 NWXoPJFQOC5yMj21JO69VQ>? NYTReo92PzJiaB?= NVXrOJFvdGWjZIOgeI8hfGinIHzvd5Mhd2ZiY3XscEB3cWGkaXzpeJkh[XRiaHnnbEBkd26lZX70doF1cW:w MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl2NUSzOEc,OjR7NEW0N|Q9N2F-
ELL-primed hNSCs MWXD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MX:wMlAzNTVizszN MX23NkBp NFzPbYpt\WGmczD0c{B1cGVibH;zd{Bw\iClZXzsJJZq[WKrbHn0fUBifCCqaXfoJINwdmOnboTyZZRqd25? M3vvTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUS1OFM1Lz5{NEm0OVQ{PDxxYU6=
SS NEToT5lE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MXyxMVExKM7:TR?= MnvKO|IhcA>? MX7EUXNQ NIDVbG1k[XW|ZYOgZUBld3OnLXTldIVv\GWwdDDpcohq[mm2aX;uJI9nKHSqZTD2bYFjcWyrdIpCpC=> M4r4WFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{W2NVEyLz5{NEe1OlEyOTxxYU6=
SeAx  MX;D[YxtKF[rYXLpcIl1gSCDc4PhfS=> M4e4ZVEuOTBizszN MX:3NkBp NX3uPGduTE2VTx?= MVnjZZV{\XNiYTDkc5NmNWSncHXu[IVvfCCrbnjpZol1cW:wIH;mJJRp\SC4aXHibYxqfHoEoB?= NVqzZm97RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3OVYyOTFpPkK0O|U3OTFzPD;hQi=>
HuT-78 M170OGNmdGxiVnnhZoltcXS7IFHzd4F6 NHHYfJIyNTFyIN88US=> NUTtUXBlPzJiaB?= M1vYdWROW09? NWDHdoJS[2G3c3XzJIEh\G:|ZT3k[ZBmdmSnboSgbY5pcWKrdHnvckBw\iC2aHWgeoli[mmuaYT5xsA> MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd3NkGxNUc,OjR5NU[xNVE9N2F-
CD4+ NVHNU|lDSXCxcITvd4l{KEG|c3H5 NVflVHpjOTEkgJpOwI0> NHP1b4ozPCCq NUj6OWh3TE2VTx?= NH;mfVhqdmS3Y3XzJIFxd3C2b4Ppd{B{fHKxbnfsfS=> MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd3NkGxNUc,OjR5NU[xNVE9N2F-
MCF-7 NWf6fm15T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGn4doIxNjR4OT2zMlc2KM7:TR?= M2DuNVUh\A>? NG\2W3Vz\WS3Y3XzJINmdGxiboXtZoVzKHOrZ37p[olk[W62bIm= MmnhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5MkiwO|goRjJ2N{K4NFc5RC:jPh?=
MCF-7/LCC1 M2fWNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzk[nAxNjR4OT2zMlc2KM7:TR?= NGfybHA2KGR? MUXy[YR2[2W|IHPlcIwhdnWvYnXyJJNq\26rZnnjZY51dHl? MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd{OEC3PEc,OjR5MkiwO|g9N2F-
MCF-7/LCC9 NF:xeVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLwNE41PjlvMz63OUDPxE1? NX7oVndGPSCm M1zWZZJm\HWlZYOgZ4VtdCCwdX3i[ZIhe2mpbnnmbYNidnSueR?= MkHJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5MkiwO|goRjJ2N{K4NFc5RC:jPh?=
HaCaT NVzvNJZ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnwdJhGOTBiwsXN M37qb|IxKG2rbh?= NH\BUlBFVVORwrC= NUnDVXU5\W6qYX7j[ZMh\X[ncn;sbY12ey2rbnT1Z4VlKGOnbHyg[5Jwf3SqIHnubIljcXSrb36= NVTlc2VwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS0NlMyOzFpPkK0OFI{OTNzPD;hQi=>
HaCaT MnjFRZBweHSxc3nzJGF{e2G7 NIflO2cyOCEEtV2= M3z3RVIxKG2rbh?= MWjEUXNQyqB? NYDCcmFW\W6qYX7j[ZMhfGinIHHwc5B1d3SrYzDl[oZm[3S|IH;mJIV3\XKxbHnteZM> MlOxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR2MkOxN|EoRjJ2NEKzNVMyRC:jPh?=
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MDA-MB-231 MV7BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M4\wOVczKGi{cx?= NI\JdpBCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDFwNkig{txONg>? NWT5coMxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3NVg1PzBpPkK3O|E5PDdyPD;hQi=>
MCF7 NF7lb3NCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NU\RbJVSPzJiaILz MY\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJwM{[g{txONg>? MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzdzOES3NEc,Ojd5MUi0O|A9N2F-
A549 MkjFRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NYrncFF4PzJiaILz NH7sRXZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IESuOEDPxE1w MkTWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5MUi0O|AoRjJ5N{G4OFcxRC:jPh?=
AD293 MVvGeY5kfGmxbjDhd5NigQ>? MYW2JIhzew>? MXfJcohq[mm2aX;uJI9nKEmITnfhcY1iNXO2aX31cIF1\WRiR1\QM2ZNSUdvdHHn[4VlKFOWQWSzJIRqdWW{aYrheIlwdiCrbjDoeY1idiCDREK5N{Bk\WyuczDpcoN2[mG2ZXSg[o9zKDZiaILzJIJ6KFenc4Tldo4h[myxdDDhcoFtgXOrczygTWM2OCB;IEWuNUDPxE1w NYr0XXhzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNlgxODBpPkOwNlI5ODByPD;hQi=>
MDA-MB-231 M4DtdWZ2dmO2aX;uJIF{e2G7 NEHWTowyKHSxIEGwJJVO NITQSWQyOiCqcoO= MmjSTY5pcWKrdHnvckBw\iCVVFHUN{BxcG:|cHjvdplt[XSrb36gZZQhXHm{N{C1JIlvKGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZZQhOSC2bzCxNEB2VSCjZoTldkAyOiCqcoOgZpkhf2W|dHXyckBjdG:2IHHuZYx6e2m| MoHkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7MES5OlYoRjJ2OUC0PVY3RC:jPh?=
MDA-MB-231 NYGxW4tRSW62aXPhcoNmeiCjc4PhfS=> M33ReVEhfG9iMUCgeW0> MoXzOFghcHK| Mk\0RY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdixiYYDvdJRwe2m|IHHu[EBk\WyudXzhdkBud3KyaH;sc4dq[2GuIHPoZY5o\XNiYYSgNUB1dyBzMDD1UUBi\nSncjC0PEBpenNiYomgcIlocHRibXnjdo9{[2:yeR?= NFO2UVg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmwOFk3Pid-MkS5NFQ6PjZ:L3G+
MDA-MB-231 MXHGeY5kfGmxbjDhd5NigQ>? MVWxJJRwKDFyIIXN Ml65NVIhcHK| Mm\NSIVkemWjc3WgbY4hW1SDVEOgdJJwfGWrbjDlfJBz\XO|aX;uJIlvKGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZZQhOSC2bzCxNEB2VSCjZoTldkAyOiCqcoOgZpkhf2W|dHXyckBjdG:2IHHuZYx6e2m| MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDlyNEm2Okc,OjR7MES5OlY9N2F-
MCF7 MX;GeY5kfGmxbjDhd5NigQ>? M2\sVVEzKGi{cx?= MUjJcohq[mm2aX;uJI9nKFOWQWSzJJBpd3OyaH;yfYxifGmxbjDheEB[PzB3IHnuJIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiMUKgbJJ{KGK7IGfld5Rmem5iYnzveEBidmGueYPpdy=> NE\HSoY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkO5OlY5QSd-Mk[zPVY3QDl:L3G+
MDA-MB-435S NVTyW29GTnWwY4Tpc44h[XO|YYm= M4rOPVEzKGi{cx?= NYPSTmtbUW6qaXLpeIlwdiCxZjDTWGFVOyCyaH;zdIhwenmuYYTpc44h[XRiWUewOUBqdiCqdX3hckBOTEFvTVKtOFM2WyClZXzsd{Bi\nSncjCxNkBpenNiYomgW4V{fGW{bjDicI91KGGwYXz5d4l{ M1rTZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4M{m2Olg6Lz5{NkO5OlY5QTxxYU6=
MDA-MB-231 M3LwemZ2dmO2aX;uJIF{e2G7 NICwN3oyOiCqcoO= NETwboNKdmirYnn0bY9vKG:oIGPURXQ{KHCqb4PwbI9zgWyjdHnvckBifCC\N{C1JIlvKGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZYZ1\XJiMUKgbJJ{KGK7IGfld5Rmem5iYnzveEBidmGueYPpdy=> NGjvdJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkO5OlY5QSd-Mk[zPVY3QDl:L3G+

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-STAT3 / STAT3 ; 

PubMed: 25261365     


(A) PC3M-1E8 cells were treated with different doses of Stattic for 4 h. (B) PC3M-1E8 cells were treated with 10 μM Stattic for different time points. 

Survivin / c-Myc / Bcl-xl ; 

PubMed: 25261365     


Western blot analysis of STAT3 downstream targets in PC3M-1E8 cells treated with 10 μM Stattic for 24 h. 

PARP / C-PARP / Caspase-3 / C-Caspse-3 ; 

PubMed: 23382914     


NPC cells were exposed to the indicated concentrations of Stattic for 48 h; apoptotic cells were measured by western blot analysis of cleaved PARP and cleaved caspase-3. Protein levels were quantified using ImageJ software. 

25261365 23382914
Immunofluorescence
p-STAT3 / STAT3 / Survivin ; 

PubMed: 25261365     


Cellular localization of pSTAT3 and survivin (green) was observed by confocal microscopy after immunofluorescent staining of PC3M-1E8 cancer cells treated with 10 μM Stattic.

25261365
Growth inhibition assay
Cell viability; 

PubMed: 23382914     


Stattic inhibits the cell viability of NPC cells in a time-dependent manner. CNE2 cells were treated with 8 µM Stattic for the indicated times, and cell viability was measured by the MTT assay. 

23382914
ELISA
BDNF; 

PubMed: 27456333     


BDNF secretion was analyzed using ELISA in A549 and H1299 cells treated with or without Stattic. Results are shown as the mean ± S.E. n = 3; *p < 0.05, vs Control group, Student’s t-test. 

27456333

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

- 合并

高通量筛选和荧光偏振检测:

在约30°C下进行筛选。通过实验化合物与STAT1, STAT5, 和 Lck 的SH2结构域结合的类似实验验证筛选的特异性。所有FP实验的Buffer组分的终浓度为10 mM HEPES(pH 7.5),1 mM EDTA,0.1% Nonidet P-40,50 mM NaCl,和10% DMSO。二硫苏糖醇的存在对抑制活性是必不可少的。肽序列为:STAT3,5-carboxyfluorescein-GY(PO3H2)LPQTV-NH2; STAT1, 5-carboxyfluorescein-GY(PO3H2)DKPHVL;STAT5, 5-carboxyfluorescein-GY(PO3H2)LVLDKW; 和 Lck, 5-carboxyfluorescein-GY(PO3H2)EEIP。在 30°C下进行特异性分析, 使用150 nM蛋白(STAT1,STAT3,和STAT5)。在37°C下进行分析,使用370 nM 蛋白(STAT3)或100 nM蛋白 (Lck)。蛋白与实验化合物在Eppendorf管中在指定温度环境下温育60分钟,然后加入相应的5-carboxyfluorescein标记的肽(终浓度为10 nM)。混合物至少平衡30分钟,然后在室温下测量。实验化合物在20×stock在DMSO中稀释到指定浓度。使用 SigmaPlot绘制结合曲线和抑制曲线。独立实验中,所有竞争曲线都需重复三次。
细胞实验:

[2]

- 合并
  • Cell lines: Ly3细胞
  • Concentrations: ~2.5 μM
  • Incubation Time: 48小时
  • Method:

    MTS


    (Only for Reference)
动物实验:

[2]

- 合并
  • Animal Models: Ly3亲本NOD/SCID IL2R移植瘤
  • Dosages: 每天3.75 mg/kg
  • Administration: 瘤内注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 42 mg/mL (198.87 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O
10mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 211.19
化学式

C8H5NO4S

CAS号 19983-44-9
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    We need to dissolve the compound for i.p. injection, could you give me some suggestions?

  • 回答:

    S7024 Stattic can be dissolved in 2% DMSO/PEG 300/dd H2O at 8 mg/mL as a clear solution.

STAT Signaling Pathway Map

相关STAT产品

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID