Stattic

目录号:S7024

仅限科研使用

Stattic 是第一个非肽类STAT3小分子抑制剂,有效抑制STAT3激活和核易位,IC50为5.1 μM,其作用于STAT3的选择性远高于STAT1。Stattic 可诱导凋亡。

Stattic Chemical Structure

CAS: 19983-44-9

规格 价格 库存 购买数量
10mM (1mL in DMSO) RMB 730.64 现货
RMB 901.23 现货
RMB 2375.1 现货
大包装 有超大折扣

今日订购,明日送达 全国免运费 分装免费 分装成小规格产品(单支最小为1mg)
如1支10mg产品可分装为10支1mg产品

全国免费电话:400-668-6834   |   Email:info@selleck.cn

客户使用Selleck生产的Stattic发表文献198篇:

产品安全说明书

STAT抑制剂选择性比较

相关STAT产品

生物活性

产品描述 Stattic 是第一个非肽类STAT3小分子抑制剂,有效抑制STAT3激活和核易位,IC50为5.1 μM,其作用于STAT3的选择性远高于STAT1。Stattic 可诱导凋亡。
特性 Stattic是第一个非肽类小分子,抑制STAT3 SH2结构域的功能,无论在体外STAT3磷酸化状态。
靶点
STAT3 [1]
(Cell-free assay)
5.1 μM
体外研究

Stattic抑制gp130受体衍生的含磷酸化酪氨酸的肽结合到STAT3 SH2结构域,这种作用存在强烈的温度依赖性。Stattic对酪氨酸磷酸化的肽结合到酪氨酸激酶Lck的SH2结构域只有很微弱的作用效果。Stattic不抑制其他两个二聚体转录因子(c-Myc/Max 和 Jun/Jun)的二聚化。Stattic抑制荧光素标记的磷酸化肽段结合到STAT1和STAT5b的SH2域。Stattic浓度为10 μM,选择性抑制DNA与STAT3二聚体结合。Stattic抑制STAT3在Tyr705位点磷酸化,而对STAT1在Tyr701(HepG2细胞)位点磷酸化或 JAK1, JAK2, 和c-Src(MDA-MB-231和MDA-MB-235S细胞)磷酸化几乎没有抑制效果。Stattic增加STAT3依赖性的乳腺癌细胞系的凋亡率。[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
H9c2 MnTTSpVv[3Srb36gRZN{[Xl? NFvyNoQyOOLCid88US=> NGCzcpc16oDLaB?= MXHy[ZZmenOnczD0bIUh\W[oZXP0d{Bw\iCLTD2yOy=> MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjN|OU[zN{c,OjZ|M{m2N|M9N2F-
NPC  MUnGeY5kfGmxbjDBd5NigQ>? NWXOZmtLOC15LkWgxtVO MnPMZYJwdGm|aHXzJGVOXC2uaXvlJI1wdGWldXzhdkBidHSncnH0bY9veyxiYX7kJINmdGxibXnndoF1cW:wIHHu[EBqdn[jc3nvckBqdmS3Y3XkJIJ6KFKNSWCgb45w[2umb4fu M4fzT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUG1OFMxLz5{NUmxOVQ{ODxxYU6=
HASMC MVLGeY5kfGmxbjDBd5NigQ>? NVPwUIw2OS5{NT21JO69VQ>? NIjLSoUzOCCvaX6= M4fvbGROW00EoB?= NUfMXGJGcW6qaXLpeJMheC1qWTmtV3RCXC1zLEOsOUB{cWewYXzzxsA> Mn3aQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6NEm2NlIoRjJ3OES5OlIzRC:jPh?=
H9c2  M{DMemZ2dmO2aX;uJGF{e2G7 Ml23Nk8yOCEQvF2= MnfQNkBp MXTEUXNQyqB? M4HEb4Fjem:pYYTld:KhfGinIHP5eI9xem:2ZXP0bZZmKGWoZnXjeJMhd2ZiSVytNlch[WejaX7zeEBUUA>? M1vybVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEKwPVA4Lz5{NUiyNFkxPzxxYU6=
A431 Mm\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEG5TGwzyqEQvF2= MoHHNuKhcA>? NYTS[mtL[myxY3vzJGVITi2{ZY\ldpNm\CCmZXPy[YF{\XNiaX6gZ4VtdCC4aXHibYxqfHl? MlrUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5MkC0N|UoRjJ3N{KwOFM2RC:jPh?=
A431 M{LEWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX:5cVFIOsLizszN NY\PNXd4OsLiaB?= M{LYSIlv[3KnYYPld{BqdiCjcH;weI9{cXNiaX7keYNm\CCkeTDzbIlsd26rbh?= MoOzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5MkC0N|UoRjJ3N{KwOFM2RC:jPh?=
SiHa NWPQZXMyS2WubDDWbYFjcWyrdImgRZN{[Xl? M2C1d|UuPzVibl2= M1vTS|I1yqCqwrC= MU\zbI94eyCvb4LwbI9td2e7IH;mJIEhfHmyaXPhcEBieG:ydH;0bYMh[2WubDDhcoQh\G:|ZT3k[ZBmdmSnboSgcI9{eyCxZjDj[YxtKH[rYXLpcIl1gcLi NWCz[mNCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW1N|k3PDRpPkK1OVM6PjR2PD;hQi=>
SiHa NWfZPJlyTnWwY4Tpc44hSXO|YYm= NFfmTJE2NTd3IH7N M4mwdlI1yqCqwrC= MmrxdoVlfWOnczD0bIXDqHCqb4PwbI9zgWyjdHnvckBifCC2aHWgeJlzd3OrbnWgdoV{cWS3ZTC3NFXDqA>? MnPyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3M{m2OFQoRjJ3NUO5OlQ1RC:jPh?=
ECA109 MmnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE[4fYMxNTJyIN88US=> NWmxTGRYOjUEoHlCpC=> NIfBOJBKSzVyPUWuOVAh|ryP M365fFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NEmyOFgxLz5{NUS5NlQ5ODxxYU6=
TE13 MnO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPmb5pNOC1{MDFOwG0> Mn\xNlTDqGkEoB?= NUf5OmV6UUN3ME22MlE2yqEQvF2= MkHpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2OUK0PFAoRjJ3NEmyOFgxRC:jPh?=
KYSE150  NEK1b3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFu4T2QxNTJyIN88US=> MlixNlTDqGkEoB?= MX;JR|UxRTF{Lk[0xsDPxE1? NYHEdodERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW0PVI1QDBpPkK1OFkzPDhyPD;hQi=>
ECA109 NITBOIFEdG:wb3flcolkKFO3co\peoFtKEG|c3H5 M2DUSFAvPcLizszN NGPNbIUzPMLiaNMg M{LaWJN2eHC{ZYPz[ZMhfGinIHPsc45w\2WwaXOg[o9zdWG2aX;u MoDmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2OUK0PFAoRjJ3NEmyOFgxRC:jPh?=
TE13 NXrGepZzS2yxbn;n[Y5q[yCVdYL2bZZidCCDc4PhfS=> NWCxV2h[OC53wrFOwG0> NGPkcXozPMLiaNMg Ml;Jd5VxeHKnc4Pld{B1cGViY3zvco9o\W6rYzDmc5Ju[XSrb36= M2HtclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NEmyOFgxLz5{NUS5NlQ5ODxxYU6=
KYSE150  M1vYTmNtd26xZ3XubYMhW3W{dnn2ZYwhSXO|YYm= MlS2NE42yqEQvF2= M2nFU|I1yqCqwrC= MXXzeZBxemW|c3XzJJRp\SClbH;uc4dmdmmlIH\vdo1ifGmxbh?= MkHLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2OUK0PFAoRjJ3NEmyOFgxRC:jPh?=
ECA109 NHG1SmRHfW6ldHnvckBCe3OjeR?= NX75dGFOOC53wrFOwG0> MkHZNlTDqGkEoB?= NXjt[HE1\W6qYX7j[ZMhUVJvaX7keYNm\CCpZX7ldoF1cW:wIH;mJGRUSnN? MoiwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2OUK0PFAoRjJ3NEmyOFgxRC:jPh?=
PC3M-1E8 MUXGeY5kfGmxbjDBd5NigQ>? NWPJOI95Oi53L{WvNVAh|ryP MXywMVQhcA>? NUn6SpZHcW6qaXLpeJMhfGinIGPURXQ{KGGldHn2ZZRqd25iaX6gZUBld3OnLTDhcoQhfGmvZT3k[ZBmdmSnboSgcYFvdmW{wrC= NHLufpE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUK2NVM3PSd-MkWyOlE{PjV:L3G+
PC3M-1E8 M3f3bmZ2dmO2aX;uJGF{e2G7 MmPoNVAh|ryP NYj6bHRpOjRiaB?= M3LVcIRwf26{ZXf1cIF1\XNiQnPsMZhNNCC|dYL2bZZqdiCjbnSgZ{1OgWN? M3WyfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Mk[xN|Y2Lz5{NUK2NVM3PTxxYU6=
PC3M-1E8 M2T0OWZ2dmO2aX;uJGF{e2G7 MXexNEDPxE1? NVvmcGdSOjRiaB?= MWfpcohq[mm2czDJUE03KGmwZIXj[YQhW1SDVEOgZYN1cX[jdHnvckBidmRidHjlJGlNNTZvaX7keYNm\CCVVFHUN{Bi[3SrdnH0bY9v NGP2[nY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUK2NVM3PSd-MkWyOlE{PjV:L3G+
PC3M-1E8 MUfDcI9vd2enbnnjJHN2en[rdnHsJGF{e2G7 MYmyMlUwPS9zMDFOwG0> Moj1bY5pcWKrdIRCpJRp\SClb3zvcpkh\m:{bXH0bY9vKHOrZ37p[olk[W62bIm= M{P1[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Mk[xN|Y2Lz5{NUK2NVM3PTxxYU6=
MDA-MB-231 MoPUSpVv[3Srb36gRZN{[Xl? NIL0OZgzOCEQvF2= MnG3NkBp MYTlfIhq[mm2czDTcoFqdCCjbnSgSU1k[WSqZYLpckBmgHC{ZYPzbY9v MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTF3M{O0PUc,OjVzNUOzOFk9N2F-
H9c2 NF[0c5NHfW6ldHnvckBCe3OjeR?= Mm\JNlAhyrWP MoDmN|AhdWmw NG\mcndFVVORwrC= MXjhZo9tcXOqZYOgdJJweG:ob3ytbY5lfWOnZDDBT3QheGixc4Doc5J6dGG2aX;uJIF1KGKxdHigd4VzPDd|IHHu[EB1cHJ|MEi= M3jI[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MUC1NFY4Lz5{NUGwOVA3PzxxYU6=
HaCaT  Mnr3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfBcXQyOCEEtV2= NIe4[o8zOCCvaX6= NGf4TZFFVVORwrC= NUHRXFlO\W6qYX7j[ZMhe2:{YX\lcoljNSCjbnSgd5VvcXSrbnniMYlv\HWlZXSg[5Jwf3SqIHnubIljcXSrb36= NFOxSlY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUCxN|kxPyd-MkWwNVM6ODd:L3G+
Caki-1 NWq0OYF6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUK3ZYhGOTBiwsXN NUfXc4t{OjBibXnu Mom4SG1UV8Li NFXRTGpmdmijbnPld{B{d3KjZnXubYIuKGGwZDDzeY5qfGmwaXKtbY5lfWOnZDDndo94fGhiaX7obYJqfGmxbh?= MmjUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyMUO5NFcoRjJ3MEGzPVA4RC:jPh?=
HaCaT  MV\BdI9xfG:|aYOgRZN{[Xl? NGrvVIgyOCEEtV2= NX;HZZRZOjBibXnu MlfaSG1UV8Li MVvpcoNz\WG|ZYOgdJJweG:{dHnvcpMhd2ZiYYDvdJRwfGmlIHPlcIx{KGS3ZTD0c{B1emWjdH3lcpQhf2m2aDDzc5Ji\mWwaXKgc5Ihe3WwaYTpcolj MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTBzM{mwO{c,OjVyMUO5NFc9N2F-
FHL-primed hNSCs NHXwN5FE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MXewMlAzNTVizszN M{m4b|czKGh? NV\VSpkydGWjZIOgeI8hfGinIHzvd5Mhd2ZiY3XscEB3cWGkaXzpeJkh[XRiaHnnbEBkd26lZX70doF1cW:w MnjSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NEW0N|QoRjJ2OUS1OFM1RC:jPh?=
ELL-primed hNSCs MXjD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NITlWFAxNjB{LUWg{txO MV63NkBp NGr4Npdt\WGmczD0c{B1cGVibH;zd{Bw\iClZXzsJJZq[WKrbHn0fUBifCCqaXfoJINwdmOnboTyZZRqd25? MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl2NUSzOEc,OjR7NEW0N|Q9N2F-
SS NYfLNFBHS2WubDDWbYFjcWyrdImgRZN{[Xl? NFzCUXQyNTFyIN88US=> NVXJd4FyPzJiaB?= NUHXbGhwTE2VTx?= NH[3R3lk[XW|ZYOgZUBld3OnLXTldIVv\GWwdDDpcohq[mm2aX;uJI9nKHSqZTD2bYFjcWyrdIpCpC=> NFXCepE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEe1OlEyOSd-MkS3OVYyOTF:L3G+
SeAx  M4WyNGNmdGxiVnnhZoltcXS7IFHzd4F6 NUG5O4VOOS1zMDFOwG0> M2fiWlczKGh? M3i4WGROW09? NXzpS|dL[2G3c3XzJIEh\G:|ZT3k[ZBmdmSnboSgbY5pcWKrdHnvckBw\iC2aHWgeoli[mmuaYT5xsA> M1ziNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{W2NVEyLz5{NEe1OlEyOTxxYU6=
HuT-78 MV\D[YxtKF[rYXLpcIl1gSCDc4PhfS=> M2\QcVEuOTBizszN NU[4RWdEPzJiaB?= MWXEUXNQ M3LvOINifXOnczDhJIRwe2VvZHXw[Y5l\W62IHnubIljcXSrb36gc4YhfGinII\pZYJqdGm2edMg NUjsSoZURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3OVYyOTFpPkK0O|U3OTFzPD;hQi=>
CD4+ MV;BdI9xfG:|aYOgRZN{[Xl? M2S1NVEx6oDLzszt NFnBeZozPCCq NXf6Xox5TE2VTx?= NGLJRYxqdmS3Y3XzJIFxd3C2b4Ppd{B{fHKxbnfsfS=> Mm\lQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5NU[xNVEoRjJ2N{W2NVEyRC:jPh?=
MCF-7 Mmr0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYSwMlQ3QS1|Lke1JO69VQ>? NVH4VIRUPSCm Mo\GdoVlfWOnczDj[YxtKG63bXLldkB{cWewaX\pZ4FvfGy7 Mo\HQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5MkiwO|goRjJ2N{K4NFc5RC:jPh?=
MCF-7/LCC1 M{XRfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVSwMlQ3QS1|Lke1JO69VQ>? MVq1JIQ> NEj4eHZz\WS3Y3XzJINmdGxiboXtZoVzKHOrZ37p[olk[W62bIm= NHLFOmg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEeyPFA4QCd-MkS3NlgxPzh:L3G+
MCF-7/LCC9 M2T2PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPSfVBHOC52NkmtN{44PSEQvF2= MUe1JIQ> NFH2Umxz\WS3Y3XzJINmdGxiboXtZoVzKHOrZ37p[olk[W62bIm= Ml;3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5MkiwO|goRjJ2N{K4NFc5RC:jPh?=
HaCaT NEXqXXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jGdlExKML3TR?= MUWyNEBucW5? NFLmcodFVVORwrC= M{nGbIVvcGGwY3XzJIV3\XKxbHnteZMucW6mdXPl[EBk\WyuIHfyc5d1cCCrbnjpZol1cW:w M2W1bFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEKzNVMyLz5{NESyN|E{OTxxYU6=
HaCaT NHTSNVlCeG:ydH;zbZMhSXO|YYm= MX:xNEDDvU1? Ml7DNlAhdWmw NGPjN5BFVVORwrC= MWPlcohidmOnczD0bIUh[XCxcITveIlkKGWoZnXjeJMhd2ZiZY\ldo9tcW23cx?= M3fBWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEKzNVMyLz5{NESyN|E{OTxxYU6=
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RAW264.7 NXXKOYNUTnWwY4Tpc44hSXO|YYm= M3[1fVExKM7:TR?= MWqxNkBp M1;hdYFjem:pYYTld{B1cGVibWLORUBmgHC{ZYPzbY9veyCxZjDKRWszNCCVVFHUNUwhW1SDVEKsJIFv\CCVVFHUN{BqdmS3Y3XkJIJ6KESRTjDhcoQhXC1{IITvfIlv MofhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2NUS0N|EoRjJ{NEW0OFMyRC:jPh?=
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SW480 NYCwU2VFS2WubDDWbYFjcWyrdImgRZN{[Xl? MYO1M|ExNzJyIN88US=> MofvO|IhcA>? M1rEbYlvcGmkaYTzJINmdGxidnnhZoltcXS7IH;mJJRp\SCDTFTIL{9ETDF|MzxCpINmdGy| MnLuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7MECzPVcoRjJzOUCwN|k4RC:jPh?=
HCT116 NXnsbFA4S2WubDDWbYFjcWyrdImgRZN{[Xl? MXG1M|ExNzJyIN88US=> MWi3NkBp Mn24bY5pcWKrdIOgZ4VtdCC4aXHibYxqfHlib3[geIhmKEGORFirM2NFOTN|K9MgZ4VtdHN? MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTlyMEO5O{c,OjF7MECzPVc9N2F-
DLD-1  NV;PbZpoS2WubDDWbYFjcWyrdImgRZN{[Xl? Mn[1OU8yOC9{MDFOwG0> NUfRV3dsPzJiaB?= NGTBfFBqdmirYnn0d{Bk\WyuII\pZYJqdGm2eTDv[kB1cGViQVzETEswS0RzM{OrxsBk\Wyucx?= NIT5[o89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUmwNFM6Pyd-MkG5NFA{QTd:L3G+
SNU387  NFnuNXhE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NHTLUo4zOMLizszNxsA> MnXmNlQhcA>? NH73OY1z\WS3Y3XzJINmdGxidnnhZoltcXS7 MlHmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF|MUG5O|UoRjJzM{GxPVc2RC:jPh?=
SNU398 NEDEU5ZE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MUeyNOKh|ryPwrC= MVeyOEBp MmLldoVlfWOnczDj[YxtKH[rYXLpcIl1gQ>? NVvIT2dGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzNVE6PzVpPkKxN|EyQTd3PD;hQi=>
HepG2 NHnQ[o9E\WyuIG\pZYJqdGm2eTDBd5NigQ>? NGPDSoYzOMLizszNxsA> MnHJNlQhcA>? NE\0Wnpz\WS3Y3XzJINmdGxidnnhZoltcXS7 M4LRUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzM{GxPVc2Lz5{MUOxNVk4PTxxYU6=
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MDA-MB-231 NE\FS5ZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M3npOFczKGi{cx?= MVXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IFXSMY5m\2G2aY\lJIFv\CC2cnnwcIUudmWpYYTpeoUhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHPlcIwheHKxbHnm[ZJifGmxbjDh[pRmeiB5MjDodpMh[nliTWTTJIF{e2G7LDDJR|UxKD1iMj64PUDPxE1w M2\i[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUC0PVY3Lz5{NEmwOFk3PjxxYU6=
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MDA-MB-231 M1THVGN6fG:2b4jpZ4l1gSCjc4PhfS=> M3vSRVQ5KGi{cx?= MVXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxMlU3KM7:TT6= NF3WZZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkO5OlY5QSd-Mk[zPVY3QDl:L3G+
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MCF7 NVPHT5lQS3m2b4TvfIlkcXS7IHHzd4F6 Ml64OFghcHK| NV\LN3VZS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMj6xOkDPxE1w NWTXOJV7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zPVY3QDlpPkK2N|k3Pjh7PD;hQi=>
A549 M1vKdGN6fG:2b4jpZ4l1gSCjc4PhfS=> M1i4NVQ5KGi{cx?= NUC0flR4S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMj61JO69VS5? NWHW[2NMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zPVY3QDlpPkK2N|k3Pjh7PD;hQi=>
DU145 MV\DfZRwfG:6aXPpeJkh[XO|YYm= MonGOFghcHK| M2LSPGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGRWOTR3IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{LkWg{txONg>? M3HITFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4M{m2Olg6Lz5{NkO5OlY5QTxxYU6=
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HCT116 MkP4RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MmLGO|IhcHK| MoDPRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ2SxNVYh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEGuNFgh|ryPLh?= M{TRRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{G4OFcxLz5{N{exPFQ4ODxxYU6=
MDA-MB-231 MVXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MYS3NkBpenN? MWDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQT3NRk0zOzFiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFEvPjhizszNMi=> M{jDdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{G4OFcxLz5{N{exPFQ4ODxxYU6=
MCF7 NIDD[XVCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M4TXPFczKGi{cx?= MoLSRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{LkO2JO69VS5? MnPwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5MUi0O|AoRjJ5N{G4OFcxRC:jPh?=
A549 MknlRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NUH2SW9TPzJiaILz MnjYRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNUS5JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB2LkSg{txONg>? M3nMVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{G4OFcxLz5{N{exPFQ4ODxxYU6=
AD293 MlnJSpVv[3Srb36gZZN{[Xl? MojuOkBpenN? NGroc2tKdmirYnn0bY9vKG:oIFnGUodidW2jLYP0bY12dGG2ZXSgS2ZRN0[OQVeteIFo\2WmIGPURXQ{KGSrbXXybZpifGmxbjDpckBpfW2jbjDBSFI6OyClZXzsd{BqdmO3YnH0[YQh\m:{IE[gbJJ{KGK7IGfld5Rmem5iYnzveEBidmGueYPpd{whUUN3MDC9JFUvOSEQvF2u NIXDR3U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEKyPFAxOCd-M{CyNlgxODB:L3G+
MDA-MB-231 NGe3[JBHfW6ldHnvckBie3OjeR?= NEH3RlEyKHSxIEGwJJVO MlrqNVIhcHK| M36yWGlvcGmkaYTpc44hd2ZiU2TBWFMheGixc4Doc5J6dGG2aX;uJIF1KFS7ckewOUBqdiCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIF1KDFidH:gNVAhfU1iYX\0[ZIhOTJiaILzJIJ6KHenc4Tldo4h[myxdDDhcoFtgXOrcx?= NXq0UHNvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NFQ6PjZpPkK0PVA1QTZ4PD;hQi=>
MDA-MB-231 M1vEW2FvfGmlYX7j[ZIh[XO|YYm= NXewXoNUOSC2bzCxNEB2VQ>? MVu0PEBpenN? M1HQO2FvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25uIHHwc5B1d3OrczDhcoQh[2WubIXsZZIhdW:{cHjvcI9ocWOjbDDjbIFv\2W|IHH0JFEhfG9iMUCgeW0h[W[2ZYKgOFghcHK|IHL5JIxq\2i2IH3pZ5Jwe2OxcIm= NUjj[|lsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NFQ6PjZpPkK0PVA1QTZ4PD;hQi=>
MDA-MB-231 M17sdmZ2dmO2aX;uJIF{e2G7 NWjvfZBqOSC2bzCxNEB2VQ>? M1POR|EzKGi{cx?= NVm5T5ozTGWlcnXhd4UhcW5iU2TBWFMheHKxdHXpckBmgHC{ZYPzbY9vKGmwIHj1cYFvKE2GQT3NRk0zOzFiY3XscJMh[XRiMTD0c{AyOCC3TTDh[pRmeiBzMjDodpMh[nlid3XzeIVzdiCkbH;0JIFv[Wy7c3nz MlHYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7MES5OlYoRjJ2OUC0PVY3RC:jPh?=
MCF7 M2LW[GZ2dmO2aX;uJIF{e2G7 MYixNkBpenN? NXL2Voo4UW6qaXLpeIlwdiCxZjDTWGFVOyCyaH;zdIhwenmuYYTpc44h[XRiWUewOUBqdiCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFEzKGi{czDifUBY\XO2ZYLuJIJtd3RiYX7hcJl{cXN? NFzMSIU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkO5OlY5QSd-Mk[zPVY3QDl:L3G+
MDA-MB-435S MY\GeY5kfGmxbjDhd5NigQ>? Mne5NVIhcHK| MVLJcohq[mm2aX;uJI9nKFOWQWSzJJBpd3OyaH;yfYxifGmxbjDheEB[PzB3IHnuJIh2dWGwIF3ERU1OSi12M{XTJINmdGy|IHHmeIVzKDF{IHjyd{BjgSCZZYP0[ZJvKGKub4SgZY5idHm|aYO= MoTVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ|OU[2PFkoRjJ4M{m2Olg6RC:jPh?=
MDA-MB-231 NXO4c3N2TnWwY4Tpc44h[XO|YYm= Mmr2NVIhcHK| NH31fnRKdmirYnn0bY9vKG:oIGPURXQ{KHCqb4PwbI9zgWyjdHnvckBifCC\N{C1JIlvKGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZYZ1\XJiMUKgbJJ{KGK7IGfld5Rmem5iYnzveEBidmGueYPpdy=> NYnlXo9tRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zPVY3QDlpPkK2N|k3Pjh7PD;hQi=>
Assay
Methods Test Index PMID
Western blot PARP / C-PARP / Caspase-3 / C-Caspse-3 Survivin / c-Myc / Bcl-xl p-STAT3 / STAT3 23382914 25261365
Immunofluorescence p-STAT3 / STAT3 / Survivin 25261365
Growth inhibition assay Cell viability 23382914
ELISA BDNF 27456333

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

  • 高通量筛选和荧光偏振检测:

    在约30°C下进行筛选。通过实验化合物与STAT1, STAT5, 和 Lck 的SH2结构域结合的类似实验验证筛选的特异性。所有FP实验的Buffer组分的终浓度为10 mM HEPES(pH 7.5),1 mM EDTA,0.1% Nonidet P-40,50 mM NaCl,和10% DMSO。二硫苏糖醇的存在对抑制活性是必不可少的。肽序列为:STAT3,5-carboxyfluorescein-GY(PO3H2)LPQTV-NH2; STAT1, 5-carboxyfluorescein-GY(PO3H2)DKPHVL;STAT5, 5-carboxyfluorescein-GY(PO3H2)LVLDKW; 和 Lck, 5-carboxyfluorescein-GY(PO3H2)EEIP。在 30°C下进行特异性分析, 使用150 nM蛋白(STAT1,STAT3,和STAT5)。在37°C下进行分析,使用370 nM 蛋白(STAT3)或100 nM蛋白 (Lck)。蛋白与实验化合物在Eppendorf管中在指定温度环境下温育60分钟,然后加入相应的5-carboxyfluorescein标记的肽(终浓度为10 nM)。混合物至少平衡30分钟,然后在室温下测量。实验化合物在20×stock在DMSO中稀释到指定浓度。使用 SigmaPlot绘制结合曲线和抑制曲线。独立实验中,所有竞争曲线都需重复三次。

细胞实验:

[2]

  • Cell lines: Ly3细胞
  • Concentrations: ~2.5 μM
  • Incubation Time: 48小时
  • Method:

    MTS

动物实验:

[2]

  • Animal Models: Ly3亲本NOD/SCID IL2R移植瘤
  • Dosages: 每天3.75 mg/kg
  • Administration: 瘤内注射

溶解度(25°C)

体外

体内

从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5%DMSO+40%PEG300+5%Tween80+50%ddH2O

0.545mg/ml

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 211.19
化学式

C8H5NO4S

CAS号 19983-44-9
储存条件 3年 -20°C 粉状
2年 -80°C 溶于溶剂

动物体内配方计算器(澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)

mg/kg g μL

第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于μL DMSO溶液(母液浓度mg/mL,:如该浓度超过该批次药物DMSO溶解度,请先联系Selleck);

体内配方配制方法:μL DMSO母液,加入μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入μL ddH2O,混匀澄清。

体内配方配制方法:μL DMSO母液,加入μL Corn oil,混匀澄清。

注意:1. 首先保证母液是澄清的;
2.一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。

摩尔浓度计算器

质量 浓度 体积 分子量

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

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常见问题及建议解决方法

问题 1:
We need to dissolve the compound for i.p. injection, could you give me some suggestions?

回答:
S7024 Stattic can be dissolved in 2% DMSO/PEG 300/dd H2O at 8 mg/mL as a clear solution.

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