Stattic

For research use only. Not for use in humans.

目录号:S7024

Stattic Chemical Structure

CAS No. 19983-44-9

Stattic 是第一个非肽类STAT3小分子抑制剂,有效抑制STAT3激活和核易位,IC50为5.1 μM,其作用于STAT3的选择性远高于STAT1。Stattic 可诱导凋亡。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 730.64 现货
RMB 901.23 现货
RMB 1392.12 现货
RMB 2375.1 现货
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客户使用Selleck生产的Stattic发表文献139篇:

产品安全说明书

STAT抑制剂选择性比较

生物活性

产品描述 Stattic 是第一个非肽类STAT3小分子抑制剂,有效抑制STAT3激活和核易位,IC50为5.1 μM,其作用于STAT3的选择性远高于STAT1。Stattic 可诱导凋亡。
特性 Stattic是第一个非肽类小分子,抑制STAT3 SH2结构域的功能,无论在体外STAT3磷酸化状态。
靶点
STAT3 [1]
(Cell-free assay)
5.1 μM
体外研究

Stattic抑制gp130受体衍生的含磷酸化酪氨酸的肽结合到STAT3 SH2结构域,这种作用存在强烈的温度依赖性。Stattic对酪氨酸磷酸化的肽结合到酪氨酸激酶Lck的SH2结构域只有很微弱的作用效果。Stattic不抑制其他两个二聚体转录因子(c-Myc/Max 和 Jun/Jun)的二聚化。Stattic抑制荧光素标记的磷酸化肽段结合到STAT1和STAT5b的SH2域。Stattic浓度为10 μM,选择性抑制DNA与STAT3二聚体结合。Stattic抑制STAT3在Tyr705位点磷酸化,而对STAT1在Tyr701(HepG2细胞)位点磷酸化或 JAK1, JAK2, 和c-Src(MDA-MB-231和MDA-MB-235S细胞)磷酸化几乎没有抑制效果。Stattic增加STAT3依赖性的乳腺癌细胞系的凋亡率。[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
H9c2 NXK5PJZFTnWwY4Tpc44hSXO|YYm= NYDYOVltOTEkgJpOwG0> NIDZS2U16oDLaB?= MlTBdoV3\XK|ZYOgeIhmKGWoZnXjeJMhd2ZiSVytNlc> NF;q[2g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkOzPVY{Oyd-Mk[zN|k3OzN:L3G+
NPC  M{LTXmZ2dmO2aX;uJGF{e2G7 NHjk[msxNTdwNTFCuW0> MXvhZo9tcXOqZYOgSW1VNWyra3WgcY9t\WO3bHHyJIFtfGW{YYTpc45{NCCjbnSgZ4VtdCCvaXfyZZRqd25iYX7kJIlvfmG|aX;uJIlv\HWlZXSgZpkhWkuLUDDrco9kc2Sxd36= MkL3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV7MUW0N|AoRjJ3OUG1OFMxRC:jPh?=
HASMC Mom1SpVv[3Srb36gRZN{[Xl? NIDpPZUyNjJ3LUWg{txO M1nKVlIxKG2rbh?= M{[5SWROW00EoB?= NV;4R416cW6qaXLpeJMheC1qWTmtV3RCXC1zLEOsOUB{cWewYXzzxsA> MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh2OU[yNkc,OjV6NEm2NlI9N2F-
H9c2  MXvGeY5kfGmxbjDBd5NigQ>? NHXENG4zNzFyIN88US=> Mn7aNkBp MWHEUXNQyqB? NV[3b5JM[WK{b3fheIV{yqC2aHWgZ5l1d3C{b4TlZ5RqfmViZX\m[YN1eyCxZjDJUE0zPyCjZ3HpcpN1KFOK M2SwcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEKwPVA4Lz5{NUiyNFkxPzxxYU6=
A431 NYjHWZk1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljiNuKh|ryP MX2yxsBp NVW3VG1Z[myxY3vzJGVITi2{ZY\ldpNm\CCmZXPy[YF{\XNiaX6gZ4VtdCC4aXHibYxqfHl? NV\qUGFVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3NlA1OzVpPkK1O|IxPDN3PD;hQi=>
A431 M1u4Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkj3NuKh|ryP Mm\4NuKhcA>? NUHTS3R6cW6lcnXhd4V{KGmwIHHwc5B1d3OrczDpcoR2[2WmIHL5JJNpcWuxbnnu MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd{MESzOUc,OjV5MkC0N|U9N2F-
SiHa MXvD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NFrqNng2NTd3IH7N MWSyOOKhcMLi NHq3SJh{cG:5czDtc5JxcG:ub3f5JI9nKGFidInwbYNidCCjcH;weI91cWNiY3XscEBidmRiZH;z[U1l\XCnbnTlcpQhdG:|czDv[kBk\WyuII\pZYJqdGm2edMg MnHVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3M{m2OFQoRjJ3NUO5OlQ1RC:jPh?=
SiHa NYTXXJcyTnWwY4Tpc44hSXO|YYm= M1jCTlUuPzVibl2= NXzx[mZQOjUEoHlCpC=> MlXpdoVlfWOnczD0bIXDqHCqb4PwbI9zgWyjdHnvckBifCC2aHWgeJlzd3OrbnWgdoV{cWS3ZTC3NFXDqA>? MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTV|OU[0OEc,OjV3M{m2OFQ9N2F-
ECA109 MknlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY[5WndsOC1{MDFOwG0> Ml7hNlTDqGkEoB?= NX7wTnY4UUN3ME21MlUxKM7:TR?= MnnyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2OUK0PFAoRjJ3NEmyOFgxRC:jPh?=
TE13 NFHCR2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\jNE0zOCEQvF2= Mn22NlTDqGkEoB?= NH:5[4dKSzVyPU[uNVXDqM7:TR?= MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR7MkS4NEc,OjV2OUK0PFA9N2F-
KYSE150  Moi1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXSwMVIxKM7:TR?= MnPGNlTDqGkEoB?= M4L0W2lEPTB;MUKuOlTDqM7:TR?= NVjFTHp5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW0PVI1QDBpPkK1OFkzPDhyPD;hQi=>
ECA109 MX3DcI9vd2enbnnjJHN2en[rdnHsJGF{e2G7 NH23bmgxNjYEoN88US=> MViyOOKhcMLi NVe2TGNZe3WycILld5NmeyC2aHWgZ4xwdm:pZX7pZ{Bnd3KvYYTpc44> MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR7MkS4NEc,OjV2OUK0PFA9N2F-
TE13 M{O4ZmNtd26xZ3XubYMhW3W{dnn2ZYwhSXO|YYm= MlPsNE42yqEQvF2= NWOw[4ZpOjUEoHlCpC=> NHrqTm9{fXCycnXzd4V{KHSqZTDjcI9vd2enbnnjJIZwem2jdHnvci=> MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR7MkS4NEc,OjV2OUK0PFA9N2F-
KYSE150  NGLEemJEdG:wb3flcolkKFO3co\peoFtKEG|c3H5 M3zSZVAvPcLizszN M3XKZlI1yqCqwrC= MWDzeZBxemW|c3XzJJRp\SClbH;uc4dmdmmlIH\vdo1ifGmxbh?= NX\uXnlpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW0PVI1QDBpPkK1OFkzPDhyPD;hQi=>
ECA109 M33R[WZ2dmO2aX;uJGF{e2G7 NFnib3MxNjYEoN88US=> Mm\YNlTDqGkEoB?= Mk\m[Y5p[W6lZYOgTXIucW6mdXPl[EBo\W6ncnH0bY9vKG:oIFTTRpM> NHnQW4c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUS5NlQ5OCd-MkW0PVI1QDB:L3G+
PC3M-1E8 MV3GeY5kfGmxbjDBd5NigQ>? NYr5fHRIOi53L{WvNVAh|ryP NUfOXlVqOC12IHi= Mnu1bY5pcWKrdIOgeIhmKFOWQWSzJIFkfGm4YYTpc44hcW5iYTDkc5NmNSCjbnSgeIlu\S2mZYDlcoRmdnRibXHucoVzyqB? MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTJ4MUO2OUc,OjV{NkGzOlU9N2F-
PC3M-1E8 MWrGeY5kfGmxbjDBd5NigQ>? MXWxNEDPxE1? NUfIdm9rOjRiaB?= Mm\m[I94dnKnZ4XsZZRmeyCEY3ytfGwtKHO3co\peolvKGGwZDDjMW16[w>? M3XLcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Mk[xN|Y2Lz5{NUK2NVM3PTxxYU6=
PC3M-1E8 MYTGeY5kfGmxbjDBd5NigQ>? NYizNnJxOTBizszN MlO0NlQhcA>? M3PxWIlvcGmkaYTzJGlNNTZiaX7keYNm\CCVVFHUN{Bi[3SrdnH0bY9vKGGwZDD0bIUhUUxvNj3pcoR2[2WmIGPURXQ{KGGldHn2ZZRqd25? MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTJ4MUO2OUc,OjV{NkGzOlU9N2F-
PC3M-1E8 M2Djb2Ntd26xZ3XubYMhW3W{dnn2ZYwhSXO|YYm= MkPpNk42NzVxMUCg{txO MXvpcohq[mm2c9MgeIhmKGOxbH;ufUBnd3KvYYTpc44he2mpbnnmbYNidnSueR?= NV\pRW9[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyOlE{PjVpPkK1NlYyOzZ3PD;hQi=>
MDA-MB-231 NV7RPIZ{TnWwY4Tpc44hSXO|YYm= MljWNlAh|ryP NYDIUmdXOiCq M{SzPYV5cGmkaYTzJHNv[WmuIHHu[EBGNWOjZHjldolvKGW6cILld5Nqd25? NHrB[mg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUG1N|M1QSd-MkWxOVM{PDl:L3G+
H9c2 NXrtbXBoTnWwY4Tpc44hSXO|YYm= MoS1NlAhyrWP MW[zNEBucW5? NHjvSYhFVVORwrC= MYDhZo9tcXOqZYOgdJJweG:ob3ytbY5lfWOnZDDBT3QheGixc4Doc5J6dGG2aX;uJIF1KGKxdHigd4VzPDd|IHHu[EB1cHJ|MEi= MkDuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVzMEWwOlcoRjJ3MUC1NFY4RC:jPh?=
HaCaT  NX:0TmRKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTBbG9DOTBiwsXN NF\HZ|MzOCCvaX6= M1fFemROW00EoB?= NVzD[3E4\W6qYX7j[ZMhe2:{YX\lcoljNSCjbnSgd5VvcXSrbnniMYlv\HWlZXSg[5Jwf3SqIHnubIljcXSrb36= Mkj1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyMUO5NFcoRjJ3MEGzPVA4RC:jPh?=
Caki-1 NHuyR5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLyNVAhyrWP NVnafWplOjBibXnu M{\jOmROW00EoB?= Mlrk[Y5p[W6lZYOgd49z[W[nbnniMUBidmRic4XubZRqdmmkLXnu[JVk\WRiZ4Lve5RpKGmwaHnibZRqd25? M3XKd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MEGzPVA4Lz5{NUCxN|kxPzxxYU6=
HaCaT  MVPBdI9xfG:|aYOgRZN{[Xl? NX:1WXJVOTBiwsXN NW\odHJVOjBibXnu M{PxWmROW00EoB?= M3racIlv[3KnYYPld{Bxem:yb4L0bY9veyCxZjDhdI9xfG:2aXOgZ4VtdHNiZIXlJJRwKHS{ZXH0cYVvfCC5aYToJJNwemGoZX7pZkBweiC|dX7peIlvcWJ? MoK3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyMUO5NFcoRjJ3MEGzPVA4RC:jPh?=
FHL-primed hNSCs MXXD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MmLiNE4xOi13IN88US=> Ml\uO|IhcA>? NXTXUI5mdGWjZIOgeI8hfGinIHzvd5Mhd2ZiY3XscEB3cWGkaXzpeJkh[XRiaHnnbEBkd26lZX70doF1cW:w NYLIOXM1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5OFU1OzRpPkK0PVQ2PDN2PD;hQi=>
ELL-primed hNSCs NVv5RWgzS2WubDDWbYFjcWyrdImgRZN{[Xl? Mo\wNE4xOi13IN88US=> M3niW|czKGh? NIHZR4Vt\WGmczD0c{B1cGVibH;zd{Bw\iClZXzsJJZq[WKrbHn0fUBifCCqaXfoJINwdmOnboTyZZRqd25? M{LGOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUS1OFM1Lz5{NEm0OVQ{PDxxYU6=
SS NEXWXIFE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NEPZ[WIyNTFyIN88US=> NXnDe|l4PzJiaB?= M2rBSmROW09? MXrjZZV{\XNiYTDkc5NmNWSncHXu[IVvfCCrbnjpZol1cW:wIH;mJJRp\SC4aXHibYxqfHoEoB?= M3zTUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{W2NVEyLz5{NEe1OlEyOTxxYU6=
SeAx  M2fjemNmdGxiVnnhZoltcXS7IFHzd4F6 MUmxMVExKM7:TR?= NEH0eIQ4OiCq MUjEUXNQ NEXxZmpk[XW|ZYOgZUBld3OnLXTldIVv\GWwdDDpcohq[mm2aX;uJI9nKHSqZTD2bYFjcWyrdIpCpC=> MoDVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5NU[xNVEoRjJ2N{W2NVEyRC:jPh?=
HuT-78 MmKyR4VtdCCYaXHibYxqfHliQYPzZZk> M{XFdVEuOTBizszN NILkZZc4OiCq MVrEUXNQ MWDjZZV{\XNiYTDkc5NmNWSncHXu[IVvfCCrbnjpZol1cW:wIH;mJJRp\SC4aXHibYxqfHoEoB?= MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd3NkGxNUc,OjR5NU[xNVE9N2F-
CD4+ NIHa[4dCeG:ydH;zbZMhSXO|YYm= NWLmS4c6OTEkgJpOwI0> MnvmNlQhcA>? M3W5WGROW09? MWTpcoR2[2W|IHHwc5B1d3OrczDzeJJwdmeueR?= NIrNNIY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEe1OlEyOSd-MkS3OVYyOTF:L3G+
MCF-7 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjV[Y4xNjR4OT2zMlc2KM7:TR?= NYm2SoQ6PSCm MorWdoVlfWOnczDj[YxtKG63bXLldkB{cWewaX\pZ4FvfGy7 MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd{OEC3PEc,OjR5MkiwO|g9N2F-
MCF-7/LCC1 NIPLWoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXiwXVZrOC52NkmtN{44PSEQvF2= MV61JIQ> MX\y[YR2[2W|IHPlcIwhdnWvYnXyJJNq\26rZnnjZY51dHl? NFruRZI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEeyPFA4QCd-MkS3NlgxPzh:L3G+
MCF-7/LCC9 Mke4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;Te|AvPDZ7LUOuO|Uh|ryP MorGOUBl MmDwdoVlfWOnczDj[YxtKG63bXLldkB{cWewaX\pZ4FvfGy7 NX7XVo5rRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3NlgxPzhpPkK0O|I5ODd6PD;hQi=>
HaCaT NX\aT2JxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3lNVAhyrWP MUeyNEBucW5? MX3EUXNQyqB? MVflcohidmOnczDleoVzd2yrbYXzMYlv\HWlZXSgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdg>? M3HjTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEKzNVMyLz5{NESyN|E{OTxxYU6=
HaCaT M2nWXGFxd3C2b4Ppd{BCe3OjeR?= NF3sbmcyOCEEtV2= NGTDVHUzOCCvaX6= NGfyO3pFVVORwrC= NH25TYlmdmijbnPld{B1cGViYYDvdJRwfGmlIHXm[oVkfHNib3[g[ZZmem:uaX31dy=> MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDR{M{GzNUc,OjR2MkOxN|E9N2F-
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SUM-159 NUHnOpZ6TnWwY4Tpc44hSXO|YYm= MVGxNEDDvU1? NWDydHNYOjRiaB?= NUjOfmN7TE2VT9Mg MV\y[YR2[2W|IGCtV3RCXDNiZYjwdoV{e2mxbh?= NFrVS4E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO3OlU5Pid-MkSzO|Y2QDZ:L3G+
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MDA-MB-435S MYfDfZRwfG:6aXPpeJkh[XO|YYm= NVLUR5dWPDhiaILz MnO2R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUSzOXMh[2WubIOgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFEvQDdizszNMi=> NX2yT4Q1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zPVY3QDlpPkK2N|k3Pjh7PD;hQi=>
MCF7 MlTqR5l1d3SxeHnjbZR6KGG|c3H5 MofSOFghcHK| NXHlNJpvS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMj6xOkDPxE1w MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjN7Nk[4PUc,OjZ|OU[2PFk9N2F-
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PANC1 M2PsT2N6fG:2b4jpZ4l1gSCjc4PhfS=> NX3vN3d[PDhiaILz Mnv0R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGFPSzFiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJwOTFOwG0v NFG0S|E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkO5OlY5QSd-Mk[zPVY3QDl:L3G+
HCT116 NW\kUGxKSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NXTx[plrPzJiaILz NHzQTYFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFEyPiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNU4xQCEQvF2u NUHoVoxJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3NVg1PzBpPkK3O|E5PDdyPD;hQi=>
MDA-MB-231 Mnu1RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MUi3NkBpenN? MmK4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRFGtUWIuOjNzIHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyNjZ6IN88UU4> NEP5Vmk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{exPFQ4OCd-Mke3NVg1PzB:L3G+
MCF7 M1\jfGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M2\Ud|czKGi{cx?= NF7hUodCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKuN|Yh|ryPLh?= MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzdzOES3NEc,Ojd5MUi0O|A9N2F-
A549 NWfJb|dpSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MXG3NkBpenN? MYHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDRwNDFOwG0v M3XURlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{G4OFcxLz5{N{exPFQ4ODxxYU6=
AD293 MmTuSpVv[3Srb36gZZN{[Xl? Mny1OkBpenN? NGrpTZRKdmirYnn0bY9vKG:oIFnGUodidW2jLYP0bY12dGG2ZXSgS2ZRN0[OQVeteIFo\2WmIGPURXQ{KGSrbXXybZpifGmxbjDpckBpfW2jbjDBSFI6OyClZXzsd{BqdmO3YnH0[YQh\m:{IE[gbJJ{KGK7IGfld5Rmem5iYnzveEBidmGueYPpd{whUUN3MDC9JFUvOSEQvF2u NX;UOWhuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNlgxODBpPkOwNlI5ODByPD;hQi=>
MDA-MB-231 M4DX[GZ2dmO2aX;uJIF{e2G7 NETTcIQyKHSxIEGwJJVO MnHsNVIhcHK| NH7xcWJKdmirYnn0bY9vKG:oIGPURXQ{KHCqb4PwbI9zgWyjdHnvckBifCCWeYK3NFUhcW5iaIXtZY4hVUSDLV3CMVI{OSClZXzsd{BifCBzIITvJFExKHWPIHHmeIVzKDF{IHjyd{BjgSC5ZYP0[ZJvKGKub4SgZY5idHm|aYO= M4LPeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUC0PVY3Lz5{NEmwOFk3PjxxYU6=
MDA-MB-231 M1XHT2FvfGmlYX7j[ZIh[XO|YYm= MVqxJJRwKDFyIIXN NXv0SWNbPDhiaILz MmnYRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdixiYYDvdJRwe2m|IHHu[EBk\WyudXzhdkBud3KyaH;sc4dq[2GuIHPoZY5o\XNiYYSgNUB1dyBzMDD1UUBi\nSncjC0PEBpenNiYomgcIlocHRibXnjdo9{[2:yeR?= NGfWRXg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmwOFk3Pid-MkS5NFQ6PjZ:L3G+
MDA-MB-231 M2nYS2Z2dmO2aX;uJIF{e2G7 M3fkW|EhfG9iMUCgeW0> Ml3JNVIhcHK| NVXtSFk{TGWlcnXhd4UhcW5iU2TBWFMheHKxdHXpckBmgHC{ZYPzbY9vKGmwIHj1cYFvKE2GQT3NRk0zOzFiY3XscJMh[XRiMTD0c{AyOCC3TTDh[pRmeiBzMjDodpMh[nlid3XzeIVzdiCkbH;0JIFv[Wy7c3nz NGe0PVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmwOFk3Pid-MkS5NFQ6PjZ:L3G+
MCF7 MY\GeY5kfGmxbjDhd5NigQ>? MmPDNVIhcHK| MluyTY5pcWKrdHnvckBw\iCVVFHUN{BxcG:|cHjvdplt[XSrb36gZZQhYTdyNTDpckBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEGyJIhzeyCkeTDX[ZN1\XKwIHLsc5Qh[W6jbInzbZM> NUTzNFJJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zPVY3QDlpPkK2N|k3Pjh7PD;hQi=>
MDA-MB-435S NF;iSolHfW6ldHnvckBie3OjeR?= NYn3TJRnOTJiaILz MXjJcohq[mm2aX;uJI9nKFOWQWSzJJBpd3OyaH;yfYxifGmxbjDheEB[PzB3IHnuJIh2dWGwIF3ERU1OSi12M{XTJINmdGy|IHHmeIVzKDF{IHjyd{BjgSCZZYP0[ZJvKGKub4SgZY5idHm|aYO= NFn6cXQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkO5OlY5QSd-Mk[zPVY3QDl:L3G+
MDA-MB-231 Ml7NSpVv[3Srb36gZZN{[Xl? NUnLdmsyOTJiaILz NVjBOYZkUW6qaXLpeIlwdiCxZjDTWGFVOyCyaH;zdIhwenmuYYTpc44h[XRiWUewOUBqdiCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIFnfGW{IEGyJIhzeyCkeTDX[ZN1\XKwIHLsc5Qh[W6jbInzbZM> MkHtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ|OU[2PFkoRjJ4M{m2Olg6RC:jPh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-STAT3 / STAT3 ; 

PubMed: 25261365     


(A) PC3M-1E8 cells were treated with different doses of Stattic for 4 h. (B) PC3M-1E8 cells were treated with 10 μM Stattic for different time points. 

Survivin / c-Myc / Bcl-xl ; 

PubMed: 25261365     


Western blot analysis of STAT3 downstream targets in PC3M-1E8 cells treated with 10 μM Stattic for 24 h. 

PARP / C-PARP / Caspase-3 / C-Caspse-3 ; 

PubMed: 23382914     


NPC cells were exposed to the indicated concentrations of Stattic for 48 h; apoptotic cells were measured by western blot analysis of cleaved PARP and cleaved caspase-3. Protein levels were quantified using ImageJ software. 

25261365 23382914
Immunofluorescence
p-STAT3 / STAT3 / Survivin ; 

PubMed: 25261365     


Cellular localization of pSTAT3 and survivin (green) was observed by confocal microscopy after immunofluorescent staining of PC3M-1E8 cancer cells treated with 10 μM Stattic.

25261365
Growth inhibition assay
Cell viability; 

PubMed: 23382914     


Stattic inhibits the cell viability of NPC cells in a time-dependent manner. CNE2 cells were treated with 8 µM Stattic for the indicated times, and cell viability was measured by the MTT assay. 

23382914
ELISA
BDNF; 

PubMed: 27456333     


BDNF secretion was analyzed using ELISA in A549 and H1299 cells treated with or without Stattic. Results are shown as the mean ± S.E. n = 3; *p < 0.05, vs Control group, Student’s t-test. 

27456333

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

- 合并

高通量筛选和荧光偏振检测:

在约30°C下进行筛选。通过实验化合物与STAT1, STAT5, 和 Lck 的SH2结构域结合的类似实验验证筛选的特异性。所有FP实验的Buffer组分的终浓度为10 mM HEPES(pH 7.5),1 mM EDTA,0.1% Nonidet P-40,50 mM NaCl,和10% DMSO。二硫苏糖醇的存在对抑制活性是必不可少的。肽序列为:STAT3,5-carboxyfluorescein-GY(PO3H2)LPQTV-NH2; STAT1, 5-carboxyfluorescein-GY(PO3H2)DKPHVL;STAT5, 5-carboxyfluorescein-GY(PO3H2)LVLDKW; 和 Lck, 5-carboxyfluorescein-GY(PO3H2)EEIP。在 30°C下进行特异性分析, 使用150 nM蛋白(STAT1,STAT3,和STAT5)。在37°C下进行分析,使用370 nM 蛋白(STAT3)或100 nM蛋白 (Lck)。蛋白与实验化合物在Eppendorf管中在指定温度环境下温育60分钟,然后加入相应的5-carboxyfluorescein标记的肽(终浓度为10 nM)。混合物至少平衡30分钟,然后在室温下测量。实验化合物在20×stock在DMSO中稀释到指定浓度。使用 SigmaPlot绘制结合曲线和抑制曲线。独立实验中,所有竞争曲线都需重复三次。
细胞实验:

[2]

- 合并
  • Cell lines: Ly3细胞
  • Concentrations: ~2.5 μM
  • Incubation Time: 48小时
  • Method:

    MTS


    (Only for Reference)
动物实验:

[2]

- 合并
  • Animal Models: Ly3亲本NOD/SCID IL2R移植瘤
  • Dosages: 每天3.75 mg/kg
  • Administration: 瘤内注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 42 mg/mL (198.87 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O
10mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 211.19
化学式

C8H5NO4S

CAS号 19983-44-9
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    We need to dissolve the compound for i.p. injection, could you give me some suggestions?

  • 回答:

    S7024 Stattic can be dissolved in 2% DMSO/PEG 300/dd H2O at 8 mg/mL as a clear solution.

STAT Signaling Pathway Map

相关STAT产品

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID