Stattic

For research use only. Not for use in humans.

目录号:S7024

Stattic Chemical Structure

CAS No. 19983-44-9

Stattic 是第一个非肽类STAT3小分子抑制剂,有效抑制STAT3激活和核易位,IC50为5.1 μM,其作用于STAT3的选择性远高于STAT1。Stattic 可诱导凋亡。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 730.64 现货
RMB 901.23 现货
RMB 1392.12 现货
RMB 2375.1 现货
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客户使用Selleck生产的Stattic发表文献184篇:

产品安全说明书

STAT抑制剂选择性比较

生物活性

产品描述 Stattic 是第一个非肽类STAT3小分子抑制剂,有效抑制STAT3激活和核易位,IC50为5.1 μM,其作用于STAT3的选择性远高于STAT1。Stattic 可诱导凋亡。
特性 Stattic是第一个非肽类小分子,抑制STAT3 SH2结构域的功能,无论在体外STAT3磷酸化状态。
靶点
STAT3 [1]
(Cell-free assay)
5.1 μM
体外研究

Stattic抑制gp130受体衍生的含磷酸化酪氨酸的肽结合到STAT3 SH2结构域,这种作用存在强烈的温度依赖性。Stattic对酪氨酸磷酸化的肽结合到酪氨酸激酶Lck的SH2结构域只有很微弱的作用效果。Stattic不抑制其他两个二聚体转录因子(c-Myc/Max 和 Jun/Jun)的二聚化。Stattic抑制荧光素标记的磷酸化肽段结合到STAT1和STAT5b的SH2域。Stattic浓度为10 μM,选择性抑制DNA与STAT3二聚体结合。Stattic抑制STAT3在Tyr705位点磷酸化,而对STAT1在Tyr701(HepG2细胞)位点磷酸化或 JAK1, JAK2, 和c-Src(MDA-MB-231和MDA-MB-235S细胞)磷酸化几乎没有抑制效果。Stattic增加STAT3依赖性的乳腺癌细胞系的凋亡率。[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
H9c2 NXHOTWM{TnWwY4Tpc44hSXO|YYm= NITa[IoyOOLCid88US=> Mn7nOQKBkWh? MnjFdoV3\XK|ZYOgeIhmKGWoZnXjeJMhd2ZiSVytNlc> MonEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ|M{m2N|MoRjJ4M{O5OlM{RC:jPh?=
NPC  NVq1THVGTnWwY4Tpc44hSXO|YYm= NGnGOpMxNTdwNTFCuW0> NIrycZJi[m:uaYPo[ZMhTU2WLXzpb4UhdW:uZXP1cIFzKGGudHXyZZRqd26|LDDhcoQh[2WubDDtbYdz[XSrb36gZY5lKGmwdnHzbY9vKGmwZIXj[YQh[nliUlvJVEBsdm:la3Tve44> Mn\4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV7MUW0N|AoRjJ3OUG1OFMxRC:jPh?=
HASMC Ml\SSpVv[3Srb36gRZN{[Xl? NUO2NmFIOS5{NT21JO69VQ>? NX35[VN2OjBibXnu M4\ZN2ROW00EoB?= MkfDbY5pcWKrdIOgdE0pYSlvU2TBWE0yNDNuNTDzbYdv[Wy|wrC= MkPCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6NEm2NlIoRjJ3OES5OlIzRC:jPh?=
H9c2  NF;2R3FHfW6ldHnvckBCe3OjeR?= NXz6RZVHOi9zMDFOwG0> NVrhZm81OiCq MnPISG1UV8Li MnPxZYJzd2ejdHXzxsB1cGViY4n0c5Bzd3SnY4TpeoUh\W[oZXP0d{Bw\iCLTD2yO{Bi\2GrboP0JHNJ MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh{MEmwO{c,OjV6MkC5NFc9N2F-
A431 NVHtNIhFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7sO4YzyqEQvF2= MofFNuKhcA>? M{n4RYJtd2OtczDFS2YuemW4ZYLz[YQh\GWlcnXhd4V{KGmwIHPlcIwhfmmjYnnsbZR6 NIq5foI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUeyNFQ{PSd-MkW3NlA1OzV:L3G+
A431 M1j2Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NES0W3kzyqEQvF2= MnizNuKhcA>? M3nkTIlv[3KnYYPld{BqdiCjcH;weI9{cXNiaX7keYNm\CCkeTDzbIlsd26rbh?= MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd{MESzOUc,OjV5MkC0N|U9N2F-
SiHa NX7MPZV5S2WubDDWbYFjcWyrdImgRZN{[Xl? NILCW2I2NTd3IH7N MoLkNlTDqGkEoB?= NHr3V5V{cG:5czDtc5JxcG:ub3f5JI9nKGFidInwbYNidCCjcH;weI91cWNiY3XscEBidmRiZH;z[U1l\XCnbnTlcpQhdG:|czDv[kBk\WyuII\pZYJqdGm2edMg Mke1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3M{m2OFQoRjJ3NUO5OlQ1RC:jPh?=
SiHa M3TqNWZ2dmO2aX;uJGF{e2G7 M1LiUlUuPzVibl2= MX6yOOKhcMLi MmLmdoVlfWOnczD0bIXDqHCqb4PwbI9zgWyjdHnvckBifCC2aHWgeJlzd3OrbnWgdoV{cWS3ZTC3NFXDqA>? NYHiRVllRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW1N|k3PDRpPkK1OVM6PjR2PD;hQi=>
ECA109 NX\pdHRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVq4eWFbOC1{MDFOwG0> M{jwO|I1yqCqwrC= NEHCfplKSzVyPUWuOVAh|ryP MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR7MkS4NEc,OjV2OUK0PFA9N2F-
TE13 M4D4Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoruNE0zOCEQvF2= NXjFd2t6OjUEoHlCpC=> MlOxTWM2OD14LkG1xsDPxE1? MonhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2OUK0PFAoRjJ3NEmyOFgxRC:jPh?=
KYSE150  NXf4TWRxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DTfVAuOjBizszN NHnlW5MzPMLiaNMg Ml7FTWM2OD1zMj62OOKh|ryP NU[1TopvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW0PVI1QDBpPkK1OFkzPDhyPD;hQi=>
ECA109 NXTQNHc5S2yxbn;n[Y5q[yCVdYL2bZZidCCDc4PhfS=> Mo\FNE42yqEQvF2= NXn5fFQ5OjUEoHlCpC=> NVXFO5U3e3WycILld5NmeyC2aHWgZ4xwdm:pZX7pZ{Bnd3KvYYTpc44> MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR7MkS4NEc,OjV2OUK0PFA9N2F-
TE13 NVixU2NtS2yxbn;n[Y5q[yCVdYL2bZZidCCDc4PhfS=> NF7OUXkxNjYEoN88US=> NH;MPZQzPMLiaNMg NYD5d4Vze3WycILld5NmeyC2aHWgZ4xwdm:pZX7pZ{Bnd3KvYYTpc44> Mo\RQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2OUK0PFAoRjJ3NEmyOFgxRC:jPh?=
KYSE150  MojVR4xwdm:pZX7pZ{BUfXK4aY\hcEBCe3OjeR?= M3HDelAvPcLizszN NUHFNVNnOjUEoHlCpC=> MorRd5VxeHKnc4Pld{B1cGViY3zvco9o\W6rYzDmc5Ju[XSrb36= NITvWpM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUS5NlQ5OCd-MkW0PVI1QDB:L3G+
ECA109 MX\GeY5kfGmxbjDBd5NigQ>? MUSwMlXDqM7:TR?= M4HOR|I1yqCqwrC= MXXlcohidmOnczDJVk1qdmS3Y3XkJIdmdmW{YYTpc44hd2ZiRGPCdy=> MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR7MkS4NEc,OjV2OUK0PFA9N2F-
PC3M-1E8 MnnhSpVv[3Srb36gRZN{[Xl? MViyMlUwPS9zMDFOwG0> NETocY4xNTRiaB?= M1jKT4lvcGmkaYTzJJRp\SCVVFHUN{Bi[3SrdnH0bY9vKGmwIHGg[I9{\S1iYX7kJJRqdWVvZHXw[Y5l\W62IH3hco5mesLi MojlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{NkGzOlUoRjJ3Mk[xN|Y2RC:jPh?=
PC3M-1E8 MkjVSpVv[3Srb36gRZN{[Xl? MYmxNEDPxE1? NHfJPFIzPCCq MkjI[I94dnKnZ4XsZZRmeyCEY3ytfGwtKHO3co\peolvKGGwZDDjMW16[w>? M2PzNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Mk[xN|Y2Lz5{NUK2NVM3PTxxYU6=
PC3M-1E8 MnHZSpVv[3Srb36gRZN{[Xl? M3LiSVExKM7:TR?= NUfDSo1sOjRiaB?= M3\Vc4lvcGmkaYTzJGlNNTZiaX7keYNm\CCVVFHUN{Bi[3SrdnH0bY9vKGGwZDD0bIUhUUxvNj3pcoR2[2WmIGPURXQ{KGGldHn2ZZRqd25? NIfGRXE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUK2NVM3PSd-MkWyOlE{PjV:L3G+
PC3M-1E8 M4L0b2Ntd26xZ3XubYMhW3W{dnn2ZYwhSXO|YYm= Mk[xNk42NzVxMUCg{txO MUXpcohq[mm2c9MgeIhmKGOxbH;ufUBnd3KvYYTpc44he2mpbnnmbYNidnSueR?= M363NFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Mk[xN|Y2Lz5{NUK2NVM3PTxxYU6=
MDA-MB-231 MkPBSpVv[3Srb36gRZN{[Xl? NVToT2w1OjBizszN M3TVfVIhcA>? MX3lfIhq[mm2czDTcoFqdCCjbnSgSU1k[WSqZYLpckBmgHC{ZYPzbY9v MonSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVzNUOzOFkoRjJ3MUWzN|Q6RC:jPh?=
H9c2 NH[zVpBHfW6ldHnvckBCe3OjeR?= NFTRdlUzOCEEtV2= M1W2V|MxKG2rbh?= NGn2[pRFVVORwrC= MYXhZo9tcXOqZYOgdJJweG:ob3ytbY5lfWOnZDDBT3QheGixc4Doc5J6dGG2aX;uJIF1KGKxdHigd4VzPDd|IHHu[EB1cHJ|MEi= NELVUVk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUGwOVA3Pyd-MkWxNFUxPjd:L3G+
HaCaT  MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7SSHEyOCEEtV2= MYeyNEBucW5? M3T2[WROW00EoB?= Ml7a[Y5p[W6lZYOgd49z[W[nbnniMUBidmRic4XubZRqdmmkLXnu[JVk\WRiZ4Lve5RpKGmwaHnibZRqd25? NHfSe|Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUCxN|kxPyd-MkWwNVM6ODd:L3G+
Caki-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXLTIZuOTBiwsXN MmH3NlAhdWmw MVHEUXNQyqB? MVvlcohidmOnczDzc5Ji\mWwaXKtJIFv\CC|dX7peIlvcWJvaX7keYNm\CCpcn;3eIghcW6qaXLpeIlwdg>? NYPQcYFORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwNVM6ODdpPkK1NFE{QTB5PD;hQi=>
HaCaT  NH;yRVdCeG:ydH;zbZMhSXO|YYm= MW[xNEDDvU1? MX[yNEBucW5? M4nKdWROW00EoB?= M2\P[4lv[3KnYYPld{Bxem:yb4L0bY9veyCxZjDhdI9xfG:2aXOgZ4VtdHNiZIXlJJRwKHS{ZXH0cYVvfCC5aYToJJNwemGoZX7pZkBweiC|dX7peIlvcWJ? Ml3oQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyMUO5NFcoRjJ3MEGzPVA4RC:jPh?=
FHL-primed hNSCs NHXVT4lE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MnPiNE4xOi13IN88US=> NH7PUJE4OiCq NUXmcnNqdGWjZIOgeI8hfGinIHzvd5Mhd2ZiY3XscEB3cWGkaXzpeJkh[XRiaHnnbEBkd26lZX70doF1cW:w M1TufFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUS1OFM1Lz5{NEm0OVQ{PDxxYU6=
ELL-primed hNSCs NGqw[ZVE\WyuIG\pZYJqdGm2eTDBd5NigQ>? Mnz2NE4xOi13IN88US=> M4PMT|czKGh? MYjs[YFleyC2bzD0bIUhdG:|czDv[kBk\WyuII\pZYJqdGm2eTDheEBpcWeqIHPvcoNmdnS{YYTpc44> NGTpOGM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm0OVQ{PCd-MkS5OFU1OzR:L3G+
SS NYryW|JoS2WubDDWbYFjcWyrdImgRZN{[Xl? MmDUNU0yOCEQvF2= NGnMbnM4OiCq M3fRSWROW09? MneyZ4F2e2W|IHGg[I9{\S2mZYDlcoRmdnRiaX7obYJqfGmxbjDv[kB1cGVidnnhZoltcXS7wrC= M3K5OVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{W2NVEyLz5{NEe1OlEyOTxxYU6=
SeAx  M4LqXmNmdGxiVnnhZoltcXS7IFHzd4F6 MXSxMVExKM7:TR?= NXj5UpdlPzJiaB?= M3jFeGROW09? MoD5Z4F2e2W|IHGg[I9{\S2mZYDlcoRmdnRiaX7obYJqfGmxbjDv[kB1cGVidnnhZoltcXS7wrC= M2TZNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{W2NVEyLz5{NEe1OlEyOTxxYU6=
HuT-78 MVfD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NU[yPIMxOS1zMDFOwG0> NWXhTZNxPzJiaB?= NH;m[XZFVVOR M2D3[4NifXOnczDhJIRwe2VvZHXw[Y5l\W62IHnubIljcXSrb36gc4YhfGinII\pZYJqdGm2edMg NGDtVow9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEe1OlEyOSd-MkS3OVYyOTF:L3G+
CD4+ NVfCUFZ1SXCxcITvd4l{KEG|c3H5 NWDY[ZVuOTEkgJpOwI0> MlHpNlQhcA>? M3rRNWROW09? M{jOV4lv\HWlZYOgZZBweHSxc3nzJJN1em:wZ3z5 Mn;DQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5NU[xNVEoRjJ2N{W2NVEyRC:jPh?=
MCF-7 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2f5TFAvPDZ7LUOuO|Uh|ryP NUXWXYt7PSCm Ml7adoVlfWOnczDj[YxtKG63bXLldkB{cWewaX\pZ4FvfGy7 NVHKT5hrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3NlgxPzhpPkK0O|I5ODd6PD;hQi=>
MCF-7/LCC1 MkW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zMc|AvPDZ7LUOuO|Uh|ryP M2HHRVUh\A>? MnjadoVlfWOnczDj[YxtKG63bXLldkB{cWewaX\pZ4FvfGy7 MlfZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5MkiwO|goRjJ2N{K4NFc5RC:jPh?=
MCF-7/LCC9 MknmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI[3cnIxNjR4OT2zMlc2KM7:TR?= MXm1JIQ> MVXy[YR2[2W|IHPlcIwhdnWvYnXyJJNq\26rZnnjZY51dHl? MoPCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5MkiwO|goRjJ2N{K4NFc5RC:jPh?=
HaCaT NXrtVXVQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2j3VFExKML3TR?= MUOyNEBucW5? NGe5VnpFVVORwrC= NELQWXBmdmijbnPld{BmfmW{b3zpcZV{NWmwZIXj[YQh[2WubDDndo94fGhiaX7obYJqfGmxbh?= MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDR{M{GzNUc,OjR2MkOxN|E9N2F-
HaCaT NYLiOVhPSXCxcITvd4l{KEG|c3H5 MnTCNVAhyrWP Ml7ENlAhdWmw Mnf2SG1UV8Li MVnlcohidmOnczD0bIUh[XCxcITveIlkKGWoZnXjeJMhd2ZiZY\ldo9tcW23cx?= Mnf2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR2MkOxN|EoRjJ2NEKzNVMyRC:jPh?=
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MDA-MB-231 NUXKVIZWSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NFfkVXQ4OiCqcoO= Ml\zRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRFGtUWIuOjNzIHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyNjZ6IN88UU4> NEHnbXQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{exPFQ4OCd-Mke3NVg1PzB:L3G+
MCF7 NVnQdoY2SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NF63Z2k4OiCqcoO= MXrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJwM{[g{txONg>? MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzdzOES3NEc,Ojd5MUi0O|A9N2F-
A549 MYHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M4TjSVczKGi{cx?= MVjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDRwNDFOwG0v NIXzV2U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{exPFQ4OCd-Mke3NVg1PzB:L3G+
AD293 NXnNV2ozTnWwY4Tpc44h[XO|YYm= M{nO[VYhcHK| NV;QU29MUW6qaXLpeIlwdiCxZjDJSm5o[W2vYT3zeIlufWyjdHXkJGdHWC:ITFHHMZRi\2enZDDTWGFVOyCmaX3ldol7[XSrb36gbY4hcHWvYX6gRWQzQTNiY3XscJMhcW6ldXLheIVlKG[xcjC2JIhzeyCkeTDX[ZN1\XKwIHLsc5Qh[W6jbInzbZMtKEmFNUCgQUA2NjFizszNMi=> Mo\xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MkiwNFAoRjNyMkK4NFAxRC:jPh?=
MDA-MB-231 MkfOSpVv[3Srb36gZZN{[Xl? MUixJJRwKDFyIIXN MXmxNkBpenN? MlH6TY5pcWKrdHnvckBw\iCVVFHUN{BxcG:|cHjvdplt[XSrb36gZZQhXHm{N{C1JIlvKGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZZQhOSC2bzCxNEB2VSCjZoTldkAyOiCqcoOgZpkhf2W|dHXyckBjdG:2IHHuZYx6e2m| NFrzd4E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmwOFk3Pid-MkS5NFQ6PjZ:L3G+
MDA-MB-231 NFnjdo1CdnSrY3HuZ4VzKGG|c3H5 M2jpd|EhfG9iMUCgeW0> Mki1OFghcHK| MVzBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTJ|MTDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vNCCjcH;weI9{cXNiYX7kJINmdGy3bHHyJI1wenCqb3zv[4lk[WxiY3jhcodmeyCjdDCxJJRwKDFyIIXNJIFnfGW{IES4JIhzeyCkeTDsbYdpfCCvaXPyc5Nkd3C7 M4HofVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUC0PVY3Lz5{NEmwOFk3PjxxYU6=
MDA-MB-231 MmTpSpVv[3Srb36gZZN{[Xl? MoP6NUB1dyBzMDD1US=> NUXOdGpiOTJiaILz MmjQSIVkemWjc3WgbY4hW1SDVEOgdJJwfGWrbjDlfJBz\XO|aX;uJIlvKGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZZQhOSC2bzCxNEB2VSCjZoTldkAyOiCqcoOgZpkhf2W|dHXyckBjdG:2IHHuZYx6e2m| MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDlyNEm2Okc,OjR7MES5OlY9N2F-
MCF7 NE\kdXlHfW6ldHnvckBie3OjeR?= NHPweVcyOiCqcoO= MYHJcohq[mm2aX;uJI9nKFOWQWSzJJBpd3OyaH;yfYxifGmxbjDheEB[PzB3IHnuJIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiMUKgbJJ{KGK7IGfld5Rmem5iYnzveEBidmGueYPpdy=> NGP6W489[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkO5OlY5QSd-Mk[zPVY3QDl:L3G+
MDA-MB-435S M{PxV2Z2dmO2aX;uJIF{e2G7 NX7MTZpMOTJiaILz MlfhTY5pcWKrdHnvckBw\iCVVFHUN{BxcG:|cHjvdplt[XSrb36gZZQhYTdyNTDpckBpfW2jbjDNSGEuVUJvNEO1V{Bk\WyuczDh[pRmeiBzMjDodpMh[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz NG\acJk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkO5OlY5QSd-Mk[zPVY3QDl:L3G+
MDA-MB-231 M3ewXGZ2dmO2aX;uJIF{e2G7 NFfo[3IyOiCqcoO= NWnGOm4xUW6qaXLpeIlwdiCxZjDTWGFVOyCyaH;zdIhwenmuYYTpc44h[XRiWUewOUBqdiCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIFnfGW{IEGyJIhzeyCkeTDX[ZN1\XKwIHLsc5Qh[W6jbInzbZM> Mlr5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ|OU[2PFkoRjJ4M{m2Olg6RC:jPh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-STAT3 / STAT3 ; 

PubMed: 25261365     


(A) PC3M-1E8 cells were treated with different doses of Stattic for 4 h. (B) PC3M-1E8 cells were treated with 10 μM Stattic for different time points. 

Survivin / c-Myc / Bcl-xl ; 

PubMed: 25261365     


Western blot analysis of STAT3 downstream targets in PC3M-1E8 cells treated with 10 μM Stattic for 24 h. 

PARP / C-PARP / Caspase-3 / C-Caspse-3 ; 

PubMed: 23382914     


NPC cells were exposed to the indicated concentrations of Stattic for 48 h; apoptotic cells were measured by western blot analysis of cleaved PARP and cleaved caspase-3. Protein levels were quantified using ImageJ software. 

25261365 23382914
Immunofluorescence
p-STAT3 / STAT3 / Survivin ; 

PubMed: 25261365     


Cellular localization of pSTAT3 and survivin (green) was observed by confocal microscopy after immunofluorescent staining of PC3M-1E8 cancer cells treated with 10 μM Stattic.

25261365
Growth inhibition assay
Cell viability; 

PubMed: 23382914     


Stattic inhibits the cell viability of NPC cells in a time-dependent manner. CNE2 cells were treated with 8 µM Stattic for the indicated times, and cell viability was measured by the MTT assay. 

23382914
ELISA
BDNF; 

PubMed: 27456333     


BDNF secretion was analyzed using ELISA in A549 and H1299 cells treated with or without Stattic. Results are shown as the mean ± S.E. n = 3; *p < 0.05, vs Control group, Student’s t-test. 

27456333

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

- 合并

高通量筛选和荧光偏振检测:

在约30°C下进行筛选。通过实验化合物与STAT1, STAT5, 和 Lck 的SH2结构域结合的类似实验验证筛选的特异性。所有FP实验的Buffer组分的终浓度为10 mM HEPES(pH 7.5),1 mM EDTA,0.1% Nonidet P-40,50 mM NaCl,和10% DMSO。二硫苏糖醇的存在对抑制活性是必不可少的。肽序列为:STAT3,5-carboxyfluorescein-GY(PO3H2)LPQTV-NH2; STAT1, 5-carboxyfluorescein-GY(PO3H2)DKPHVL;STAT5, 5-carboxyfluorescein-GY(PO3H2)LVLDKW; 和 Lck, 5-carboxyfluorescein-GY(PO3H2)EEIP。在 30°C下进行特异性分析, 使用150 nM蛋白(STAT1,STAT3,和STAT5)。在37°C下进行分析,使用370 nM 蛋白(STAT3)或100 nM蛋白 (Lck)。蛋白与实验化合物在Eppendorf管中在指定温度环境下温育60分钟,然后加入相应的5-carboxyfluorescein标记的肽(终浓度为10 nM)。混合物至少平衡30分钟,然后在室温下测量。实验化合物在20×stock在DMSO中稀释到指定浓度。使用 SigmaPlot绘制结合曲线和抑制曲线。独立实验中,所有竞争曲线都需重复三次。
细胞实验:

[2]

- 合并
  • Cell lines: Ly3细胞
  • Concentrations: ~2.5 μM
  • Incubation Time: 48小时
  • Method:

    MTS


    (Only for Reference)
动物实验:

[2]

- 合并
  • Animal Models: Ly3亲本NOD/SCID IL2R移植瘤
  • Dosages: 每天3.75 mg/kg
  • Administration: 瘤内注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 42 mg/mL (198.87 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O
10mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 211.19
化学式

C8H5NO4S

CAS号 19983-44-9
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    We need to dissolve the compound for i.p. injection, could you give me some suggestions?

  • 回答:

    S7024 Stattic can be dissolved in 2% DMSO/PEG 300/dd H2O at 8 mg/mL as a clear solution.

STAT Signaling Pathway Map

相关STAT产品

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID