Stattic

For research use only. Not for use in humans.

目录号:S7024

Stattic Chemical Structure

CAS No. 19983-44-9

Stattic 是第一个非肽类STAT3小分子抑制剂,有效抑制STAT3激活和核易位,IC50为5.1 μM,其作用于STAT3的选择性远高于STAT1。Stattic 可诱导凋亡。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 730.64 现货
RMB 901.23 现货
RMB 1392.12 现货
RMB 2375.1 现货
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客户使用Selleck生产的Stattic发表文献169篇:

产品安全说明书

STAT抑制剂选择性比较

生物活性

产品描述 Stattic 是第一个非肽类STAT3小分子抑制剂,有效抑制STAT3激活和核易位,IC50为5.1 μM,其作用于STAT3的选择性远高于STAT1。Stattic 可诱导凋亡。
特性 Stattic是第一个非肽类小分子,抑制STAT3 SH2结构域的功能,无论在体外STAT3磷酸化状态。
靶点
STAT3 [1]
(Cell-free assay)
5.1 μM
体外研究

Stattic抑制gp130受体衍生的含磷酸化酪氨酸的肽结合到STAT3 SH2结构域,这种作用存在强烈的温度依赖性。Stattic对酪氨酸磷酸化的肽结合到酪氨酸激酶Lck的SH2结构域只有很微弱的作用效果。Stattic不抑制其他两个二聚体转录因子(c-Myc/Max 和 Jun/Jun)的二聚化。Stattic抑制荧光素标记的磷酸化肽段结合到STAT1和STAT5b的SH2域。Stattic浓度为10 μM,选择性抑制DNA与STAT3二聚体结合。Stattic抑制STAT3在Tyr705位点磷酸化,而对STAT1在Tyr701(HepG2细胞)位点磷酸化或 JAK1, JAK2, 和c-Src(MDA-MB-231和MDA-MB-235S细胞)磷酸化几乎没有抑制效果。Stattic增加STAT3依赖性的乳腺癌细胞系的凋亡率。[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
H9c2 MljzSpVv[3Srb36gRZN{[Xl? MkLnNVDjiIoQvF2= NWixPWxqPOLCiXi= NFTSfY1z\X[ncoPld{B1cGViZX\m[YN1eyCxZjDJUE0zPw>? NH7IbFk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkOzPVY{Oyd-Mk[zN|k3OzN:L3G+
NPC  Mmi2SpVv[3Srb36gRZN{[Xl? MnfBNE04NjViwsXN MnPDZYJwdGm|aHXzJGVOXC2uaXvlJI1wdGWldXzhdkBidHSncnH0bY9veyxiYX7kJINmdGxibXnndoF1cW:wIHHu[EBqdn[jc3nvckBqdmS3Y3XkJIJ6KFKNSWCgb45w[2umb4fu NFTSNFk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUmxOVQ{OCd-MkW5NVU1OzB:L3G+
HASMC NXfYUHNTTnWwY4Tpc44hSXO|YYm= MYCxMlI2NTVizszN MljkNlAhdWmw MVPEUXNQyqB? M1rUSYlvcGmkaYTzJJAuMFlrLWPURXQuOSx|LEWgd4lodmGuc9Mg MkjZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6NEm2NlIoRjJ3OES5OlIzRC:jPh?=
H9c2  NHTDSmlHfW6ldHnvckBCe3OjeR?= NWe3Rnd1Oi9zMDFOwG0> NI\wSpYzKGh? NF;PNnhFVVORwrC= NY\USWh{[WK{b3fheIV{yqC2aHWgZ5l1d3C{b4TlZ5RqfmViZX\m[YN1eyCxZjDJUE0zPyCjZ3HpcpN1KFOK MkLqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6MkC5NFcoRjJ3OEKwPVA4RC:jPh?=
A431 MlrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1H5TlLDqM7:TR?= MVuyxsBp MnPPZoxw[2u|IFXHSk1z\X[ncoPl[EBl\WO{ZXHz[ZMhcW5iY3XscEB3cWGkaXzpeJk> MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd{MESzOUc,OjV5MkC0N|U9N2F-
A431 M1XCO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXMdFMzyqEQvF2= MmriNuKhcA>? NHvMUJFqdmO{ZXHz[ZMhcW5iYYDvdJRwe2m|IHnu[JVk\WRiYomgd4hqc2:waX6= MorVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5MkC0N|UoRjJ3N{KwOFM2RC:jPh?=
SiHa NX;tc|A1S2WubDDWbYFjcWyrdImgRZN{[Xl? M3n0eFUuPzVibl2= NHnZT5QzPMLiaNMg NWG1cW5we2ixd4OgcY9zeGixbH;nfUBw\iCjIIT5dIlk[WxiYYDvdJRwfGmlIHPlcIwh[W6mIHTvd4Uu\GWyZX7k[Y51KGyxc4Ogc4Yh[2WubDD2bYFjcWyrdIpCpC=> M3\GSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NUO5OlQ1Lz5{NUWzPVY1PDxxYU6=
SiHa NUe1cXZCTnWwY4Tpc44hSXO|YYm= NVfsRVBNPS15NTDuUS=> MkTFNlTDqGkEoB?= M16wcpJm\HWlZYOgeIhmyqCyaH;zdIhwenmuYYTpc44h[XRidHjlJJR6em:|aX7lJJJme2mmdXWgO|A2yqB? MkLMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3M{m2OFQoRjJ3NUO5OlQ1RC:jPh?=
ECA109 M1m1cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fT[lAuOjBizszN MoS0NlTDqGkEoB?= NIe1S3ZKSzVyPUWuOVAh|ryP NWfkc5RvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW0PVI1QDBpPkK1OFkzPDhyPD;hQi=>
TE13 MnvQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUGwMVIxKM7:TR?= NHr0WJkzPMLiaNMg MlHnTWM2OD14LkG1xsDPxE1? MnzNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2OUK0PFAoRjJ3NEmyOFgxRC:jPh?=
KYSE150  Ml[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLWNE0zOCEQvF2= MWOyOOKhcMLi MV;JR|UxRTF{Lk[0xsDPxE1? NHjRWnI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUS5NlQ5OCd-MkW0PVI1QDB:L3G+
ECA109 MkPMR4xwdm:pZX7pZ{BUfXK4aY\hcEBCe3OjeR?= MV[wMlXDqM7:TR?= NVHx[5pDOjUEoHlCpC=> MmHqd5VxeHKnc4Pld{B1cGViY3zvco9o\W6rYzDmc5Ju[XSrb36= MnzPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2OUK0PFAoRjJ3NEmyOFgxRC:jPh?=
TE13 NU\abHRGS2yxbn;n[Y5q[yCVdYL2bZZidCCDc4PhfS=> MXewMlXDqM7:TR?= MUOyOOKhcMLi NITYVHh{fXCycnXzd4V{KHSqZTDjcI9vd2enbnnjJIZwem2jdHnvci=> MofkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2OUK0PFAoRjJ3NEmyOFgxRC:jPh?=
KYSE150  Ml\xR4xwdm:pZX7pZ{BUfXK4aY\hcEBCe3OjeR?= NFfYeIUxNjYEoN88US=> NI\HS5EzPMLiaNMg NY\wPHFve3WycILld5NmeyC2aHWgZ4xwdm:pZX7pZ{Bnd3KvYYTpc44> MlKxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2OUK0PFAoRjJ3NEmyOFgxRC:jPh?=
ECA109 M{nybGZ2dmO2aX;uJGF{e2G7 MVGwMlXDqM7:TR?= MVeyOOKhcMLi NWK5fnhr\W6qYX7j[ZMhUVJvaX7keYNm\CCpZX7ldoF1cW:wIH;mJGRUSnN? M2DQe|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NEmyOFgxLz5{NUS5NlQ5ODxxYU6=
PC3M-1E8 MV\GeY5kfGmxbjDBd5NigQ>? NGPSbXUzNjVxNT:xNEDPxE1? M1zVOVAuPCCq M3WzcYlvcGmkaYTzJJRp\SCVVFHUN{Bi[3SrdnH0bY9vKGmwIHGg[I9{\S1iYX7kJJRqdWVvZHXw[Y5l\W62IH3hco5mesLi NWfUNZg4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyOlE{PjVpPkK1NlYyOzZ3PD;hQi=>
PC3M-1E8 NUTzV41sTnWwY4Tpc44hSXO|YYm= MVGxNEDPxE1? NVW5NHFmOjRiaB?= NF;rRYpld3ewcnXneYxifGW|IFLjcE15VCxic4Xyeol3cW5iYX7kJIMuVXml MnHLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{NkGzOlUoRjJ3Mk[xN|Y2RC:jPh?=
PC3M-1E8 NEfiZZlHfW6ldHnvckBCe3OjeR?= MUWxNEDPxE1? Mn;lNlQhcA>? MkPSbY5pcWKrdIOgTWwuPiCrbnT1Z4VlKFOWQWSzJIFkfGm4YYTpc44h[W6mIITo[UBKVC14LXnu[JVk\WRiU2TBWFMh[WO2aY\heIlwdg>? NVOxSoV6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyOlE{PjVpPkK1NlYyOzZ3PD;hQi=>
PC3M-1E8 M1ny[GNtd26xZ3XubYMhW3W{dnn2ZYwhSXO|YYm= M1zCXVIvPS93L{GwJO69VQ>? MlrCbY5pcWKrdIRCpJRp\SClb3zvcpkh\m:{bXH0bY9vKHOrZ37p[olk[W62bIm= NFXMW3M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUK2NVM3PSd-MkWyOlE{PjV:L3G+
MDA-MB-231 MXXGeY5kfGmxbjDBd5NigQ>? MYOyNEDPxE1? MmTINkBp MoXj[ZhpcWKrdIOgV45icWxiYX7kJGUu[2GmaHXybY4h\XiycnXzd4lwdg>? MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTF3M{O0PUc,OjVzNUOzOFk9N2F-
H9c2 NWTtVVduTnWwY4Tpc44hSXO|YYm= M2HhcFIxKML3TR?= M3vKcFMxKG2rbh?= M1m5RWROW00EoB?= NGX3WXNi[m:uaYPo[ZMheHKxcH;mc4wucW6mdXPl[EBCU1RicHjvd5Bpd3K7bHH0bY9vKGG2IHLveIghe2W{NEezJIFv\CC2aIKzNFg> MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTFyNUC2O{c,OjVzMEWwOlc9N2F-
HaCaT  NE\1eoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjwW|IyOCEEtV2= NEPtZWMzOCCvaX6= NE[zNnZFVVORwrC= MkLa[Y5p[W6lZYOgd49z[W[nbnniMUBidmRic4XubZRqdmmkLXnu[JVk\WRiZ4Lve5RpKGmwaHnibZRqd25? NWfJbYxiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwNVM6ODdpPkK1NFE{QTB5PD;hQi=>
Caki-1 MmPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7zNVAhyrWP NFrU[2QzOCCvaX6= NVm0NXF2TE2VT9Mg Mn7K[Y5p[W6lZYOgd49z[W[nbnniMUBidmRic4XubZRqdmmkLXnu[JVk\WRiZ4Lve5RpKGmwaHnibZRqd25? M1jLXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MEGzPVA4Lz5{NUCxN|kxPzxxYU6=
HaCaT  M1\VTGFxd3C2b4Ppd{BCe3OjeR?= MkmxNVAhyrWP MnfzNlAhdWmw MXfEUXNQyqB? Ml;XbY5kemWjc3XzJJBzd3CxcoTpc45{KG:oIHHwc5B1d3SrYzDj[YxteyCmdXWgeI8hfHKnYYTt[Y51KHerdHigd49z[W[nbnniJI9zKHO3bnn0bY5q[g>? MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTBzM{mwO{c,OjVyMUO5NFc9N2F-
FHL-primed hNSCs MmjtR4VtdCCYaXHibYxqfHliQYPzZZk> NE\tbo0xNjB{LUWg{txO MnXwO|IhcA>? NFLnfoht\WGmczD0c{B1cGVibH;zd{Bw\iClZXzsJJZq[WKrbHn0fUBifCCqaXfoJINwdmOnboTyZZRqd25? MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl2NUSzOEc,OjR7NEW0N|Q9N2F-
ELL-primed hNSCs MU\D[YxtKF[rYXLpcIl1gSCDc4PhfS=> NXrjNIRKOC5yMj21JO69VQ>? MXm3NkBp M2TUe4xm[WS|IITvJJRp\SCub4PzJI9nKGOnbHygeoli[mmuaYT5JIF1KGirZ3igZ49v[2WwdILheIlwdg>? MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl2NUSzOEc,OjR7NEW0N|Q9N2F-
SS MVPD[YxtKF[rYXLpcIl1gSCDc4PhfS=> M3TWUVEuOTBizszN NVPQTGFrPzJiaB?= MmOzSG1UVw>? Mor1Z4F2e2W|IHGg[I9{\S2mZYDlcoRmdnRiaX7obYJqfGmxbjDv[kB1cGVidnnhZoltcXS7wrC= M{T1XFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{W2NVEyLz5{NEe1OlEyOTxxYU6=
SeAx  MYLD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MUmxMVExKM7:TR?= M13qWVczKGh? MoPxSG1UVw>? NUTkSmNE[2G3c3XzJIEh\G:|ZT3k[ZBmdmSnboSgbY5pcWKrdHnvckBw\iC2aHWgeoli[mmuaYT5xsA> MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd3NkGxNUc,OjR5NU[xNVE9N2F-
HuT-78 NHK2[3ZE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NYmzR3BuOS1zMDFOwG0> MkOxO|IhcA>? MWHEUXNQ NVPMXFFG[2G3c3XzJIEh\G:|ZT3k[ZBmdmSnboSgbY5pcWKrdHnvckBw\iC2aHWgeoli[mmuaYT5xsA> Mnr6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5NU[xNVEoRjJ2N{W2NVEyRC:jPh?=
CD4+ NWTGfpFmSXCxcITvd4l{KEG|c3H5 M3rKeFEx6oDLzszt MWGyOEBp NHHmc5NFVVOR MkXvbY5lfWOnczDhdI9xfG:|aYOgd5Rzd26pbIm= MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd3NkGxNUc,OjR5NU[xNVE9N2F-
MCF-7 M1r6UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXr5S2JKOC52NkmtN{44PSEQvF2= Ml\ZOUBl M2jBW5Jm\HWlZYOgZ4VtdCCwdX3i[ZIhe2mpbnnmbYNidnSueR?= M3WyT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{K4NFc5Lz5{NEeyPFA4QDxxYU6=
MCF-7/LCC1 MlzjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY[wMlQ3QS1|Lke1JO69VQ>? NHHGc4Y2KGR? MkHjdoVlfWOnczDj[YxtKG63bXLldkB{cWewaX\pZ4FvfGy7 NFHOV3c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEeyPFA4QCd-MkS3NlgxPzh:L3G+
MCF-7/LCC9 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFT6XJExNjR4OT2zMlc2KM7:TR?= M4jTbFUh\A>? MmjrdoVlfWOnczDj[YxtKG63bXLldkB{cWewaX\pZ4FvfGy7 MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd{OEC3PEc,OjR5MkiwO|g9N2F-
HaCaT M2\KcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXKxNEDDvU1? NVmweVcxOjBibXnu NVPHbHJpTE2VT9Mg Mknz[Y5p[W6lZYOg[ZZmem:uaX31d{1qdmS3Y3XkJINmdGxiZ4Lve5RpKGmwaHnibZRqd25? M{LVT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEKzNVMyLz5{NESyN|E{OTxxYU6=
HaCaT NGLCU5NCeG:ydH;zbZMhSXO|YYm= NX;lN|VjOTBiwsXN M3LF[|IxKG2rbh?= NVXWfmI2TE2VT9Mg NYjMXFZo\W6qYX7j[ZMhfGinIHHwc5B1d3SrYzDl[oZm[3S|IH;mJIV3\XKxbHnteZM> M37BS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEKzNVMyLz5{NESyN|E{OTxxYU6=
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MDA-MB-231 MlS2RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? Moq0O|IhcHK| MWfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQT3NRk0zOzFiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFEvPjhizszNMi=> MoXtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5MUi0O|AoRjJ5N{G4OFcxRC:jPh?=
MCF7 NFK4RYNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MYO3NkBpenN? NF23O5VCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKuN|Yh|ryPLh?= NEnkT4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{exPFQ4OCd-Mke3NVg1PzB:L3G+
A549 MnPQRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MlXnO|IhcHK| NXXGO41jSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC0MlQh|ryPLh?= NGDQUIc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{exPFQ4OCd-Mke3NVg1PzB:L3G+
AD293 MUHGeY5kfGmxbjDhd5NigQ>? M2Xi[FYhcHK| MnLiTY5pcWKrdHnvckBw\iCLRl7nZY1u[S2|dHnteYxifGWmIFfGVE9HVEGJLYTh[4dm\CCVVFHUN{BlcW2ncnn6ZZRqd25iaX6gbJVu[W5iQVSyPVMh[2WubIOgbY5kfWKjdHXkJIZweiB4IHjyd{BjgSCZZYP0[ZJvKGKub4SgZY5idHm|aYOsJGlEPTBiPTC1MlEh|ryPLh?= M3PvRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkK4NFAxLz5|MEKyPFAxODxxYU6=
MDA-MB-231 MYLGeY5kfGmxbjDhd5NigQ>? MmL2NUB1dyBzMDD1US=> M2i1UVEzKGi{cx?= NYLYZZY3UW6qaXLpeIlwdiCxZjDTWGFVOyCyaH;zdIhwenmuYYTpc44h[XRiVInyO|A2KGmwIHj1cYFvKE2GQT3NRk0zOzFiY3XscJMh[XRiMTD0c{AyOCC3TTDh[pRmeiBzMjDodpMh[nlid3XzeIVzdiCkbH;0JIFv[Wy7c3nz MojoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7MES5OlYoRjJ2OUC0PVY3RC:jPh?=
MDA-MB-231 MWjBcpRq[2GwY3XyJIF{e2G7 NGrZdIYyKHSxIEGwJJVO NYDjNmlNPDhiaILz MYnBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTJ|MTDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vNCCjcH;weI9{cXNiYX7kJINmdGy3bHHyJI1wenCqb3zv[4lk[WxiY3jhcodmeyCjdDCxJJRwKDFyIIXNJIFnfGW{IES4JIhzeyCkeTDsbYdpfCCvaXPyc5Nkd3C7 MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDlyNEm2Okc,OjR7MES5OlY9N2F-
MDA-MB-231 NU[yeYpkTnWwY4Tpc44h[XO|YYm= M{PHVlEhfG9iMUCgeW0> NWLxb|htOTJiaILz Mo\TSIVkemWjc3WgbY4hW1SDVEOgdJJwfGWrbjDlfJBz\XO|aX;uJIlvKGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZZQhOSC2bzCxNEB2VSCjZoTldkAyOiCqcoOgZpkhf2W|dHXyckBjdG:2IHHuZYx6e2m| NVXkZY1lRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NFQ6PjZpPkK0PVA1QTZ4PD;hQi=>
MCF7 M1ixNGZ2dmO2aX;uJIF{e2G7 MXGxNkBpenN? NILlNWZKdmirYnn0bY9vKG:oIGPURXQ{KHCqb4PwbI9zgWyjdHnvckBifCC\N{C1JIlvKGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgNVIhcHK|IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>? MlL0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ|OU[2PFkoRjJ4M{m2Olg6RC:jPh?=
MDA-MB-435S M4LKbmZ2dmO2aX;uJIF{e2G7 NVL6[2NQOTJiaILz NV\pUJVUUW6qaXLpeIlwdiCxZjDTWGFVOyCyaH;zdIhwenmuYYTpc44h[XRiWUewOUBqdiCqdX3hckBOTEFvTVKtOFM2WyClZXzsd{Bi\nSncjCxNkBpenNiYomgW4V{fGW{bjDicI91KGGwYXz5d4l{ NXjRVmV4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zPVY3QDlpPkK2N|k3Pjh7PD;hQi=>
MDA-MB-231 MV3GeY5kfGmxbjDhd5NigQ>? NUiwflc1OTJiaILz Mmi4TY5pcWKrdHnvckBw\iCVVFHUN{BxcG:|cHjvdplt[XSrb36gZZQhYTdyNTDpckBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDF{IHjyd{BjgSCZZYP0[ZJvKGKub4SgZY5idHm|aYO= Ml;5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ|OU[2PFkoRjJ4M{m2Olg6RC:jPh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-STAT3 / STAT3 ; 

PubMed: 25261365     


(A) PC3M-1E8 cells were treated with different doses of Stattic for 4 h. (B) PC3M-1E8 cells were treated with 10 μM Stattic for different time points. 

Survivin / c-Myc / Bcl-xl ; 

PubMed: 25261365     


Western blot analysis of STAT3 downstream targets in PC3M-1E8 cells treated with 10 μM Stattic for 24 h. 

PARP / C-PARP / Caspase-3 / C-Caspse-3 ; 

PubMed: 23382914     


NPC cells were exposed to the indicated concentrations of Stattic for 48 h; apoptotic cells were measured by western blot analysis of cleaved PARP and cleaved caspase-3. Protein levels were quantified using ImageJ software. 

25261365 23382914
Immunofluorescence
p-STAT3 / STAT3 / Survivin ; 

PubMed: 25261365     


Cellular localization of pSTAT3 and survivin (green) was observed by confocal microscopy after immunofluorescent staining of PC3M-1E8 cancer cells treated with 10 μM Stattic.

25261365
Growth inhibition assay
Cell viability; 

PubMed: 23382914     


Stattic inhibits the cell viability of NPC cells in a time-dependent manner. CNE2 cells were treated with 8 µM Stattic for the indicated times, and cell viability was measured by the MTT assay. 

23382914
ELISA
BDNF; 

PubMed: 27456333     


BDNF secretion was analyzed using ELISA in A549 and H1299 cells treated with or without Stattic. Results are shown as the mean ± S.E. n = 3; *p < 0.05, vs Control group, Student’s t-test. 

27456333

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

- 合并

高通量筛选和荧光偏振检测:

在约30°C下进行筛选。通过实验化合物与STAT1, STAT5, 和 Lck 的SH2结构域结合的类似实验验证筛选的特异性。所有FP实验的Buffer组分的终浓度为10 mM HEPES(pH 7.5),1 mM EDTA,0.1% Nonidet P-40,50 mM NaCl,和10% DMSO。二硫苏糖醇的存在对抑制活性是必不可少的。肽序列为:STAT3,5-carboxyfluorescein-GY(PO3H2)LPQTV-NH2; STAT1, 5-carboxyfluorescein-GY(PO3H2)DKPHVL;STAT5, 5-carboxyfluorescein-GY(PO3H2)LVLDKW; 和 Lck, 5-carboxyfluorescein-GY(PO3H2)EEIP。在 30°C下进行特异性分析, 使用150 nM蛋白(STAT1,STAT3,和STAT5)。在37°C下进行分析,使用370 nM 蛋白(STAT3)或100 nM蛋白 (Lck)。蛋白与实验化合物在Eppendorf管中在指定温度环境下温育60分钟,然后加入相应的5-carboxyfluorescein标记的肽(终浓度为10 nM)。混合物至少平衡30分钟,然后在室温下测量。实验化合物在20×stock在DMSO中稀释到指定浓度。使用 SigmaPlot绘制结合曲线和抑制曲线。独立实验中,所有竞争曲线都需重复三次。
细胞实验:

[2]

- 合并
  • Cell lines: Ly3细胞
  • Concentrations: ~2.5 μM
  • Incubation Time: 48小时
  • Method:

    MTS


    (Only for Reference)
动物实验:

[2]

- 合并
  • Animal Models: Ly3亲本NOD/SCID IL2R移植瘤
  • Dosages: 每天3.75 mg/kg
  • Administration: 瘤内注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 42 mg/mL (198.87 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O
10mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 211.19
化学式

C8H5NO4S

CAS号 19983-44-9
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    We need to dissolve the compound for i.p. injection, could you give me some suggestions?

  • 回答:

    S7024 Stattic can be dissolved in 2% DMSO/PEG 300/dd H2O at 8 mg/mL as a clear solution.

STAT Signaling Pathway Map

相关STAT产品

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID