Dabrafenib (GSK2118436)

For research use only. Not for use in humans.

目录号:S2807

Dabrafenib (GSK2118436) Chemical Structure

Molecular Weight(MW): 519.56

Dabrafenib (GSK2118436)是一种突变型BRAFV600特异性抑制剂,无细胞试验中IC50为0.7 nM,作用于B-Raf(wt)和c-Raf效果分别低7和9倍。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1481.39 现货
RMB 733.64 现货
RMB 1056.75 现货
RMB 1394.46 现货
RMB 2235.84 现货
RMB 3261.37 现货
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客户使用Selleck生产的Dabrafenib (GSK2118436)发表文献135篇:

产品安全说明书

Raf抑制剂选择性比较

生物活性

产品描述 Dabrafenib (GSK2118436)是一种突变型BRAFV600特异性抑制剂,无细胞试验中IC50为0.7 nM,作用于B-Raf(wt)和c-Raf效果分别低7和9倍。
靶点
B-Raf (V600E) [3]
(Cell-free assay)
B-Raf [3]
(Cell-free assay)
C-Raf [3]
(Cell-free assay)
0.7 nM 5.2 nM 6.3 nM
体外研究

Dabrafenib对Raf激酶具有选择性,对B-Raf的活性比其它测试过的91%的激酶高400倍。 Dabrafenib抑制B-RafV600E激酶,导致ERK磷酸化降低和抑制细胞的增值,在特异性编码突变的B-RafV600E的癌细胞中细胞停滞在G1期。

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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SK-MEL-28 MmPGT4lv[XOnIFHzd4F6 Mn;sNUBp NWPnSWRmUW6qaXLpeIlwdiCxZjDCMXJi\iCYNkCwSUBufXSjboSgbY4hcHWvYX6gV2suVUWOLUK4JINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKEWUSzDwbI9{eGixconsZZRqd25id3n0bEBKSzVyIH;mJFAvODB2IN88US=> MX6yOFkxODZ5Mx?=
HepG2 M4HrZWtqdmG|ZTDBd5NigQ>? MVjJcohq[mm2aX;uJI9nKEJvUnHmJHY3ODCHIH31eIFvfCCrbjDoeY1idiCKZYDHNkBk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiCHUlugdIhwe3Cqb4L5cIF1cW:wIIfpeIghUUN3MDDv[kAxNjByNDFOwG0> M1GyOVI1QTByNkez
COLO205 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJcohq[mm2aX;uJI9nKGi3bXHuJGNQVE9{MEWgZ4VtdCCycn;sbYZmemG2aX;uJJdqfGhiSVO1NEBw\iByLkCwO{DPxE1? NIr4TngzPDlyME[3Ny=>
HepG2 M{PYfWZ2dmO2aX;uJGF{e2G7 M4PrflQ2KG2rbh?= MUDEUXNQ MVPJcohq[mm2aX;uJI9nKEGua{WgbY4hXEeILXLleIEue3SrbYXsZZRm\CCqdX3hckBJ\XCJMjDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBUdWGmMjDwbI9{eGixconsZZRqd25idILlZZRm\CCob4KgOFUhdWmwczDwdolweiC2bzDUS2Yu[mW2YTDzeIlufWyjdHnvckBu\WG|dYLl[EBi\nSncjC2NEBucW6|IHL5JI9lgXO|ZYmgZoxwfCC|Y3HucoVzKGGwYXz5d4l{KHerdHigTWM2OCCxZjCzMlch|ryP MkHHNlQ6ODB4N{O=
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NCI-H508 NF;Pc2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\6NVAh|ryP M2fyPFczKGh? MlvlSG1UVw>? M4Xy[GlEPTB;MUCg{txO M{HLdFI{QDR2MEO4
MDA-MB-231 M2\mdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nRW|ExKM7:TR?= NFnw[Zo4OiCq Mn7sSG1UVw>? M{PqTGlEPTB;MUCg{txO M2HUeVI{QDR2MEO4
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SW480 NIXMdmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjKNVAh|ryP NFjpPG84OiCq M3HUPGROW09? Mm\KTWM2OD1zMDFOwG0> MUSyN|g1PDB|OB?=
DLD-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LGdVExKM7:TR?= NX:xO5BvPzJiaB?= NWXwXIcyTE2VTx?= MofuTWM2OD1zMDFOwG0> M1nCUFI{QDR2MEO4
HCT-116 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\NNHgyOCEQvF2= M1;kZlczKGh? NGPEVVBFVVOR M2rsWmlEPTB;MUCg{txO NXLx[GQ4OjN6NESwN|g>
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NCI-H460 MlS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnSO3EyOCEQvF2= MY[3NkBp M4HPd2ROW09? MkDpTWM2OD1zMDFOwG0> NFX1RlEzOzh2NECzPC=>
Calu-6 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXTNVAh|ryP MlnTO|IhcA>? M3fZZ2ROW09? M3LoUWlEPTB;MUCg{txO M2iyRlI{QDR2MEO4
HCC-2998 NHW3OWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrTWHNEOTBizszN NV\tVlF5PzJiaB?= NISwSnhFVVOR NH7hT4xKSzVyPUGwJO69VQ>? NX7WO3pDOjN6NESwN|g>
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BFTC-905 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrrc|AyOCEQvF2= NYHxRmZOPzJiaB?= NHK5OW9FVVOR M{XUfWlEPTB;MUCg{txO MVeyN|g1PDB|OB?=
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A172 Ml;mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYOxNEDPxE1? MYK3NkBp NEfobIVFVVOR MkntTWM2OD1zMDFOwG0> MmDUNlM5PDRyM{i=
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Hela MlThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXQZo1sOTBizszN MkPtO|IhcA>? NEK4cZJFVVOR NWjqfFR7UUN3ME2xNEDPxE1? MkTaNlM5PDRyM{i=
Hep3B MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnKeZQyOCEQvF2= NETBcIE4OiCq NXj1c5pzTE2VTx?= NWnGcY4yUUN3ME2xNEDPxE1? MYOyN|g1PDB|OB?=
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HOS Mkn2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELNeXIyOCEQvF2= NY\vVnZjPzJiaB?= M1G5RWROW09? M13NOGlEPTB;MUCg{txO NFrXT3ozOzh2NECzPC=>
HPAF-II NVvnPXQxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU[yRYJlOTBizszN NVHzOVlrPzJiaB?= MmnjSG1UVw>? NEPlSZJKSzVyPUGwJO69VQ>? Mn6yNlM5PDRyM{i=
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HT-3 NX;NfWlJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PJSVExKM7:TR?= M3nzW|czKGh? NYq0fJl[TE2VTx?= M{XRdWlEPTB;MUCg{txO NFq4O|UzOzh2NECzPC=>
HuNS-1 NUC0WoJCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DzV|ExKM7:TR?= NWPRN|IxPzJiaB?= MnXHSG1UVw>? NGrG[GRKSzVyPUGwJO69VQ>? MlLQNlM5PDRyM{i=
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Kato III M37LcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7wNVAh|ryP NXW2e403PzJiaB?= MWLEUXNQ MVTJR|UxRTFyIN88US=> NV7zSZR[OjN6NESwN|g>
KHOS-240S M3zOcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEH4WZkyOCEQvF2= NGK2eHM4OiCq Mn3PSG1UVw>? NWi2UYRQUUN3ME2xNEDPxE1? NY\YSnRROjN6NESwN|g>
KM-12 NHrRdHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3UNVAh|ryP MoKyO|IhcA>? NGr6cXFFVVOR NULyUHZSUUN3ME2xNEDPxE1? MYKyN|g1PDB|OB?=
KPL-1 MnjPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\B[mgyOCEQvF2= MXi3NkBp NYjGV|NsTE2VTx?= NVfteoRjUUN3ME2xNEDPxE1? M1fnNFI{QDR2MEO4
KYSE-30 MknWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\KN|ExKM7:TR?= MmK1O|IhcA>? NYLNO2l2TE2VTx?= MoDhTWM2OD1zMDFOwG0> NV75R5hDOjN6NESwN|g>
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MCF-7 NUn1[I5wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TyZ|ExKM7:TR?= M{LOflczKGh? M3XKPGROW09? NYPRO5pYUUN3ME2xNEDPxE1? MmfpNlM5PDRyM{i=
MC-IXC Mn;sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXviV4dJOTBizszN NE\PU|k4OiCq MmTxSG1UVw>? NGTiR|lKSzVyPUGwJO69VQ>? MWSyN|g1PDB|OB?=
MDA-MB-175 VII MlLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYixNEDPxE1? MXi3NkBp NV74PZIyTE2VTx?= NILSZ2xKSzVyPUGwJO69VQ>? Ml[3NlM5PDRyM{i=
MDA-MB-468 M2T3TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEG0TW0yOCEQvF2= MY[3NkBp NIG4TFNFVVOR NYjCOpVOUUN3ME2xNEDPxE1? M2XzbVI{QDR2MEO4
MiaPaCa NXLNbpVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIH0SmcyOCEQvF2= MWi3NkBp NHvyVlNFVVOR Mn7vTWM2OD1zMDFOwG0> NUHjToY{OjN6NESwN|g>
Molt-4 NXH6RnAzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LYOlExKM7:TR?= NIrVdlc4OiCq MUPEUXNQ M4fid2lEPTB;MUCg{txO MlnFNlM5PDRyM{i=
NCI-ADR/RES Ml7JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mor5NVAh|ryP Mkm0O|IhcA>? MX\EUXNQ M2jmbGlEPTB;MUCg{txO MlK5NlM5PDRyM{i=
NCI-H69 NVTkWJRDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVGxNEDPxE1? MYe3NkBp NITQOnlFVVOR M{LT[2lEPTB;MUCg{txO NULnSYpDOjN6NESwN|g>
NCI-H82 MnWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3W4bFExKM7:TR?= MWG3NkBp NF3VNJFFVVOR NFL6RXpKSzVyPUGwJO69VQ>? M4P0[VI{QDR2MEO4
NCI-N87 M3;oWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1ztflExKM7:TR?= MmPQO|IhcA>? MleySG1UVw>? MVvJR|UxRTFyIN88US=> MYGyN|g1PDB|OB?=
NCI-H146 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfaZnQyOCEQvF2= MVG3NkBp NEPHUItFVVOR NH7LOGdKSzVyPUGwJO69VQ>? MoK1NlM5PDRyM{i=
NCI-H157 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7zN4gyOCEQvF2= M13ac|czKGh? MWTEUXNQ MnL3TWM2OD1zMDFOwG0> NXTDfnA5OjN6NESwN|g>
NCI-H187 NVzHXXZUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYKxNEDPxE1? MnPQO|IhcA>? M3PsUWROW09? Ml76TWM2OD1zMDFOwG0> Ml\HNlM5PDRyM{i=
NCI-H209 NEnLNplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYWxNEDPxE1? NIjtcFE4OiCq NV;DfnZNTE2VTx?= MnTOTWM2OD1zMDFOwG0> NXzKUlJEOjN6NESwN|g>
NCI-H226 NXfpd4NLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHmXoVbOTBizszN MkPsO|IhcA>? MXHEUXNQ NF\DeWRKSzVyPUGwJO69VQ>? MlPBNlM5PDRyM{i=
NCI-H292 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7zNVAh|ryP MWS3NkBp MkHzSG1UVw>? MUTJR|UxRTFyIN88US=> Mln5NlM5PDRyM{i=
NCI-H322 M165d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnvZlBrOTBizszN M1PWOlczKGh? M1nSSGROW09? M1vj[GlEPTB;MUCg{txO MXKyN|g1PDB|OB?=
NCI-H358 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTEXXBwOTBizszN MU[3NkBp Mn;rSG1UVw>? MYHJR|UxRTFyIN88US=> MoDTNlM5PDRyM{i=
NCI-H520 NIHwWZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XPUVExKM7:TR?= NIPxcJk4OiCq MX7EUXNQ NHjNWIRKSzVyPUGwJO69VQ>? NFjqWIczOzh2NECzPC=>
NCI-H526 NF20[VdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M16wNlExKM7:TR?= NXmwZWpPPzJiaB?= M1vVe2ROW09? M1PDPWlEPTB;MUCg{txO M2\XV|I{QDR2MEO4
NCI-H630 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vwTlExKM7:TR?= M3fncFczKGh? NUO2W|NJTE2VTx?= NWHxbVdkUUN3ME2xNEDPxE1? M{TQWlI{QDR2MEO4
NCI-H661 MmniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY[wSYVzOTBizszN MXK3NkBp MnrwSG1UVw>? NV7B[GR7UUN3ME2xNEDPxE1? MXeyN|g1PDB|OB?=
NCI-H716 NHn2dnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjjcIJIOTBizszN M3zYNVczKGh? NHj1NYpFVVOR NV;hU4lrUUN3ME2xNEDPxE1? NHrveGkzOzh2NECzPC=>
NCI-H1563 M4XQTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWexNEDPxE1? M1n1PVczKGh? NHXPfmVFVVOR M4fQZmlEPTB;MUCg{txO MoDLNlM5PDRyM{i=
NCI-H1792 M4Xzfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVu5OVdmOTBizszN MUS3NkBp NYrMfnROTE2VTx?= NG[y[GlKSzVyPUGwJO69VQ>? M4HrS|I{QDR2MEO4
NCI-H2030 MoKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYKybHJoOTBizszN MYK3NkBp NFXFcW9FVVOR MVrJR|UxRTFyIN88US=> NH\zb5czOzh2NECzPC=>
NCI-H2052 M{PuXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY[xNEDPxE1? M1LLclczKGh? MkLiSG1UVw>? M4KwTGlEPTB;MUCg{txO Mn3INlM5PDRyM{i=
NCI-H2122 NU\ieWFRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nsOVExKM7:TR?= MmOyO|IhcA>? NV3sNGxOTE2VTx?= NE\uT4ZKSzVyPUGwJO69VQ>? NVTZUoRyOjN6NESwN|g>
NCI-H2228 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PlclExKM7:TR?= MWe3NkBp NHf0PIhFVVOR NFvidpFKSzVyPUGwJO69VQ>? NX2xcYlpOjN6NESwN|g>
OE-19 M1zNTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUSxNEDPxE1? NVL3cm5xPzJiaB?= MoPKSG1UVw>? NVzsNXFjUUN3ME2xNEDPxE1? NGTucGUzOzh2NECzPC=>
OE-21 NFm4UVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\yTXl[OTBizszN MomzO|IhcA>? M2XtOGROW09? NFzsRXpKSzVyPUGwJO69VQ>? MXyyN|g1PDB|OB?=
OE-33 NHm4cG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXBNVAh|ryP NInXSlI4OiCq M2\OOWROW09? MkLJTWM2OD1zMDFOwG0> MkT4NlM5PDRyM{i=
OVCAR-3 NU\mNXc5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXj[YpnOTBizszN MoLTO|IhcA>? NYLmd|ZxTE2VTx?= Ml7yTWM2OD1zMDFOwG0> NF;yTZQzOzh2NECzPC=>
OVCAR-4 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInLT5UyOCEQvF2= MnLqO|IhcA>? M1G4RmROW09? Mnm4TWM2OD1zMDFOwG0> MYCyN|g1PDB|OB?=
OVCAR-5 M1r0SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEW4TFIyOCEQvF2= MUO3NkBp NXrycow3TE2VTx?= NHXJUpJKSzVyPUGwJO69VQ>? NY\1Xo1MOjN6NESwN|g>
P3HR-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnx[5dyOTBizszN NH7VeHk4OiCq MVnEUXNQ MkK4TWM2OD1zMDFOwG0> NUnXSopuOjN6NESwN|g>
PC-3 M{nLcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWSxNEDPxE1? NUH3UW9VPzJiaB?= M4DEN2ROW09? Ml3PTWM2OD1zMDFOwG0> MX[yN|g1PDB|OB?=
Raji M3vGfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\BT|ExKM7:TR?= MV63NkBp MojGSG1UVw>? MmfSTWM2OD1zMDFOwG0> MmfQNlM5PDRyM{i=
RD MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrkTVN4OTBizszN MWi3NkBp MVfEUXNQ M3\zVGlEPTB;MUCg{txO NEHhTWIzOzh2NECzPC=>
RD-ES NFHrS3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LJTFExKM7:TR?= M{nzb|czKGh? MU\EUXNQ NFj1TVRKSzVyPUGwJO69VQ>? M2ThUVI{QDR2MEO4
RL M{Llemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWKxNEDPxE1? MlvqO|IhcA>? NE\BXFlFVVOR NEXYfnpKSzVyPUGwJO69VQ>? MkS2NlM5PDRyM{i=
SaOS2 NFezUIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUW1VZhPOTBizszN NWTBcIlDPzJiaB?= MnvFSG1UVw>? M{PLSWlEPTB;MUCg{txO MmfyNlM5PDRyM{i=
SCC-9 MmTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTjT3AyOCEQvF2= M3zRRlczKGh? NH7u[YdFVVOR NF3T[mRKSzVyPUGwJO69VQ>? MXGyN|g1PDB|OB?=
SCC-12 NIfqW4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HyclExKM7:TR?= MXe3NkBp MlvTSG1UVw>? MoHpTWM2OD1zMDFOwG0> M1;Vc|I{QDR2MEO4
SCC-13 NET3cVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDRfXEyOCEQvF2= NX;MRnNnPzJiaB?= M3HCeWROW09? MYPJR|UxRTFyIN88US=> NFjyc3QzOzh2NECzPC=>
SCC-15 NE\BOmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PM[VExKM7:TR?= NV\QU2JQPzJiaB?= M2XrbmROW09? MV;JR|UxRTFyIN88US=> MUKyN|g1PDB|OB?=
SCC-25 NEfNc5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LmOVExKM7:TR?= NXzBTHNNPzJiaB?= MVvEUXNQ NVHjNWdHUUN3ME2xNEDPxE1? NVfNVm8xOjN6NESwN|g>
SCLC-3 NHjsdpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nOUFExKM7:TR?= MWe3NkBp M4fwZmROW09? MYTJR|UxRTFyIN88US=> NV7OR|Y2OjN6NESwN|g>
SF-268 MnrJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3pNnkyOCEQvF2= MVu3NkBp NEHWS|FFVVOR NGC5NIVKSzVyPUGwJO69VQ>? NFf1XnEzOzh2NECzPC=>
SF-295 MoPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrkfogyOCEQvF2= NF7zXok4OiCq NWKyfGhrTE2VTx?= NEiwXmdKSzVyPUGwJO69VQ>? NEHJbVMzOzh2NECzPC=>
SJRH30 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3za[lExKM7:TR?= NYLKVZFvPzJiaB?= MXrEUXNQ NYriVod6UUN3ME2xNEDPxE1? MVKyN|g1PDB|OB?=
SK-BR-3 NYG5PZJnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1uzW|ExKM7:TR?= NUfMVY1lPzJiaB?= MmDrSG1UVw>? M2m2ZWlEPTB;MUCg{txO NHj0WZczOzh2NECzPC=>
SK-LMS-1 M3Xve2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3wNVAh|ryP MWC3NkBp MXHEUXNQ NV;iZ2k4UUN3ME2xNEDPxE1? M{ns[lI{QDR2MEO4
SK-N-DZ M1TT[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXOxNEDPxE1? NIjEcnI4OiCq NGXXSpNFVVOR NXXyZ4I5UUN3ME2xNEDPxE1? NF:xbmszOzh2NECzPC=>
SK-N-F1 NUjlXnlpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\rW|cyOCEQvF2= M1nYbFczKGh? NV3nOGdYTE2VTx?= NIqyNmpKSzVyPUGwJO69VQ>? NHK0c3gzOzh2NECzPC=>
SKOV-3 MonJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXwfJQyOCEQvF2= M2freVczKGh? MnfLSG1UVw>? NWDi[m4xUUN3ME2xNEDPxE1? Mki5NlM5PDRyM{i=
SK-UT-1 Mn3kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnrcXoyOCEQvF2= M3njWFczKGh? NEHtd|RFVVOR MnvVTWM2OD1zMDFOwG0> MUCyN|g1PDB|OB?=
SN12C MmD2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nhVlExKM7:TR?= NH[zSGo4OiCq NFHXUGNFVVOR MkLxTWM2OD1zMDFOwG0> NX7xcZduOjN6NESwN|g>
SNB-19 M1i2cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3i0O|ExKM7:TR?= MlnvO|IhcA>? MUXEUXNQ MmPUTWM2OD1zMDFOwG0> NXnHN4kyOjN6NESwN|g>
SNU-5 NXryWFdtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX6xNEDPxE1? NIjsU|g4OiCq NXu1NGszTE2VTx?= NYjCS5FvUUN3ME2xNEDPxE1? NFmybGczOzh2NECzPC=>
SNU-16 M4ToPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jmSlExKM7:TR?= Ml7YO|IhcA>? MV3EUXNQ NUO2VZFtUUN3ME2xNEDPxE1? M3uzSVI{QDR2MEO4
SNU-398 NVjK[HE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDtNVAh|ryP MVi3NkBp NHnpe4FFVVOR NVTOS5RzUUN3ME2xNEDPxE1? NUDz[VdKOjN6NESwN|g>
SNU-449 M{DlU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjVZ2tZOTBizszN MUC3NkBp M3ezc2ROW09? M2nVVGlEPTB;MUCg{txO MUmyN|g1PDB|OB?=
SR NYLmSYE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mle0NVAh|ryP MUO3NkBp NFK1d4tFVVOR NX:2T2hsUUN3ME2xNEDPxE1? NYnpflZMOjN6NESwN|g>
ST486 NH70XlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWCxNEDPxE1? M1f0VFczKGh? NEfZTpBFVVOR NEPaOXRKSzVyPUGwJO69VQ>? M3:we|I{QDR2MEO4
SW579 M{nCV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;iN|ExKM7:TR?= NGG2PVc4OiCq MkHjSG1UVw>? MV7JR|UxRTFyIN88US=> M{PQV|I{QDR2MEO4
SW684 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHjVmcyOCEQvF2= MofDO|IhcA>? NV[5N4lUTE2VTx?= NHniVmVKSzVyPUGwJO69VQ>? NGP2d|EzOzh2NECzPC=>
SW-780 NG\BU3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLGNVAh|ryP NYXBZ215PzJiaB?= NETFSo1FVVOR NF\DV2xKSzVyPUGwJO69VQ>? MkLZNlM5PDRyM{i=
SW900 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7SNVAh|ryP NY\FR5BXPzJiaB?= M1jGZWROW09? NFrldnNKSzVyPUGwJO69VQ>? Ml64NlM5PDRyM{i=
SW1088 NGrnSpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX[xNEDPxE1? Mn;5O|IhcA>? MlzXSG1UVw>? NFe1ZmFKSzVyPUGwJO69VQ>? NIHnRYQzOzh2NECzPC=>
SW1463 M2jBNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmj5NVAh|ryP MXS3NkBp NXnCUlFiTE2VTx?= M1K2OGlEPTB;MUCg{txO MUWyN|g1PDB|OB?=
SW1990 NYr5UWZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoqwNVAh|ryP NIHoUII4OiCq NYSwUXN[TE2VTx?= M3XpN2lEPTB;MUCg{txO NVnkcos5OjN6NESwN|g>
T47D NFvGVYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWGxNEDPxE1? NVHkfo9LPzJiaB?= NF35dYdFVVOR MmPITWM2OD1zMDFOwG0> NUXlUHFiOjN6NESwN|g>
TE381.T NUPYO4htT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnOTnIyOCEQvF2= MYC3NkBp M2rRTWROW09? M{jVXGlEPTB;MUCg{txO M2fLNFI{QDR2MEO4
TK-10 NFvVU4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWexNEDPxE1? NGqzTmg4OiCq Mlm5SG1UVw>? NHfTfYRKSzVyPUGwJO69VQ>? NUHW[4JVOjN6NESwN|g>
U2OS M4HYU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7VRo1uOTBizszN NEfScXc4OiCq M4DkRmROW09? NIG5S21KSzVyPUGwJO69VQ>? NWXTVW1ZOjN6NESwN|g>
U251 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVuxNEDPxE1? M{XZRVczKGh? NUG2VVBSTE2VTx?= NFXP[pdKSzVyPUGwJO69VQ>? M3G4eFI{QDR2MEO4
UACC-812 M2HFXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWmxNEDPxE1? NV3Dd|NMPzJiaB?= MVrEUXNQ NH;iT|dKSzVyPUGwJO69VQ>? NIDrb4gzOzh2NECzPC=>
YAPC MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfVTpAyOCEQvF2= MmfJO|IhcA>? NEKzcmdFVVOR MnrLTWM2OD1zMDFOwG0> MlzCNlM5PDRyM{i=
ZR-75-1 M3jaXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TKVFExKM7:TR?= MV:3NkBp M2jwN2ROW09? M1OzV2lEPTB;MUCg{txO NWHDU5ZPOjN6NESwN|g>
A375 NXzhdFYyTnWwY4Tpc44h[XO|YYm= M{HYfVEvOiEQvF2= MVm0JIg> MYPEUXNQ NUPOWFN3UW6qaXLpeIlwdiCxZjDwbI9{eGixconsZZRqd25ib3[gUWVMNCCHUlusJIFv\CCVNmC= NGLRXYwzOjN6OUS3NS=>
YUSIT1 NH\3ZmVHfW6ldHnvckBie3OjeR?= MmTMSG1UVw>? MVfy[YR2[2WmIIPlcpNqfGm4aYT5JJdqfGhiSVO1NEA,KDBwNTFOwG0> MXWyNlM5QTR5MR?=
MeWo MUTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVnEUXNQ MYXJR|UxKD1iOUi3JI5O M4nhb|I3ODF6NUK0
WiDr MXPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2nPOGROW09? NFHaeGJKSzVyIE2gO|Yhdk1? NYnnUWJpOjZyMUi1NlQ>
Colo-205 MkDKSpVv[3Srb36gZZN{[Xl? MY[xJO69VQ>? MVm0JIQ> M4Ps[2ROW09? NX\Pe2VmUW6mdXPl[EBiKGirZ3jsfUBkd22yYYLhZoxmKGOxbYDhZ5Rqd25icHjlco91gXCn MUmyOVM5OTF3Mh?=
RBW-1 NETCTZVHfW6ldHnvckBie3OjeR?= MonmNUDPxE1? NXf5[lJQTE2VTx?= M{naT25wKHKnZIXjeIlwdiCxZjDN[YshOS9{IIDoc5NxcG:{eXzheIlwdg>? M4f3SVI1QDh3Nkmw
RBO-1 M1Szd2Z2dmO2aX;uJIF{e2G7 NYjQUndQOSEQvF2= NFrCfXFFVVOR NWD4e2NbUW6qaXLpeIlwdiCxZjDN[YshOS9{IIDoc5NxcG:{eXzheIlwdg>? NYG5d5lpOjR6OEW2PVA>
RBO-2 NYrjbGlMTnWwY4Tpc44h[XO|YYm= MYmxJO69VQ>? NHfh[phFVVOR M{LubWlvcGmkaYTpc44hd2ZiIF3lb{AyNzJicHjvd5Bpd3K7bHH0bY9v NHH0U3kzPDh6NU[5NC=>
RBOW NVOzZmFuTnWwY4Tpc44h[XO|YYm= M13FU|Eh|ryP MUXEUXNQ NIrMNohKdmirYnn0bY9vKG:oIDDN[YshOS9{IIDoc5NxcG:{eXzheIlwdg>? NH3BOIgzPDh6NU[5NC=>
M257 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUmxNFAhdk1? NV7ZS2N1PzJiaB?= NGXzcpZFd2W|IH7veEBqdmirYnn0JJBzd2yrZnXyZZRqd25ib3[gUVI2PyClZXzsJIhiemKxdYLpcochf2muZDD0fZBmKEKUQV[= NXHEfIk1OjN|MUe0OFY>
LCP NGnZTWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXGxdYczOTByIH7N M1PKb|czKGh? NWGzSIZsUW6qaXLpeIlwdiCxZjDwdo9tcW[ncnH0bY9vKG:oIFzDVEBk\WyuIHjhdoJwfXKrbnegRnJCTiCYNkCwVkBufXSjboTheIlwdg>? M2PaSFI{OzF5NES2
WM266 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUexNFAhdk1? NV2xU5VNPzJiaB?= NG\pW2tKdmirYnn0bY9vKG:oIIDyc4xq\mW{YYTpc44hd2ZiV12yOlYh[2WubDDoZZJjd3W{aX7nJGJTSUZiVk[wNWQhdXW2YX70ZZRqd25? NFzKUXYzOzNzN{S0Oi=>
M257 NVvoTY43T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXzNVAxKG6P NYfTfWVWPzJiaB?= M1fYS2Rw\XNibn;0JIlvcGmkaYSgSXJMOS1{IIDoc5NxcG:{eXzheIlwdiCrbjDNNlU4KGOnbHygbIFz[m:3cnnu[{B4cWymIIT5dIUhSlKDRh?= MWWyN|MyPzR2Nh?=
LCP MmDVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{C0OFExOCCwTR?= NGHvdYw4OiCq M3HqRWlvcGmkaYSgSXJMOS1{IIDoc5NxcG:{eXzheIlwdiCrbjDMR3Ah[2WubDDoZZJjd3W{aX7nJGJTSUZiVk[wNHIhdXW2YX70ZZRqd25? NIjo[GIzOzNzN{S0Oi=>
WM266 NVT6TYp2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPyNVAxKG6P M2DvVFczKGh? NXnRT3hWUW6qaXLpeEBGWktzLUKgdIhwe3Cqb4L5cIF1cW:wIHnuJHdOOjZ4IHPlcIwhcGG{Yn;1dolv\yCEUlHGJHY3ODCGIH31eIFvfGG2aX;u M3HlOVI{OzF5NES2

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pMEK / pERK / ERK; 

PubMed: 31158244     


Cell lines as shown were treated with dabrafenib, over a dose range, for 1 hour. UT = untransfected.  Expression and/or phosphorylation of the indicated proteins were assessed by immunoblot.

p-S6 / p-AKT308 / p-AKT473; 

PubMed: 24735930     


Western blot analysis of phosphorylated proteins in MAPK and the PI3K-AKT pathway after 24 hours exposure to increasing concentrations of dabrafenib.

β-catenin; 

PubMed: 29167314     


HT-29 cells were treated with BRAF inhibitors Dabrafenib (2 μM), GDC-0879 (4 μM) or Vemurafenib (2 μM) for indicated times. The whole cell lysates were used for western blot with indicated antibodies.

31158244 24735930 29167314
Growth inhibition assay
IC50; 

PubMed: 24735930     


A panel of 23 BRAF(V600) mutant human melanoma cell lines was treated with serial dilutions (1-10,000 nM) of dabrafenib (A) for 72-120 hours to assess cell viability. The bars represent the average IC50 value of two or more independent experiments in duplicates and the error bars represent the SEM. 

24735930
体内研究 Dabrafenib(口服)抑制B-RafV600E突变的黑色素瘤(A375P)的生长,在免疫受损小鼠中皮下注射结肠癌(Colo205),Dabrafenib(口服)同样能抑制肿瘤生长。 [1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

溶解度 (25°C)

体外 DMSO 30 mg/mL (57.74 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
2% DMSO+45% PEG 300+2% Tween 80+ddH2O
5 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 519.56
化学式

C23H20F3N5O2S2

CAS号 1195765-45-7
储存条件 粉状
溶于溶剂
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04059224 Recruiting Drug: Trametinib|Drug: Dabrafenib Stage IV Melanoma|Stage III Melanoma Universitair Ziekenhuis Brussel January 28 2019 Phase 2
NCT03668431 Recruiting Drug: Dabrafenib|Drug: Trametinib|Drug: PDR001 Metastatic Colorectal Cancer Massachusetts General Hospital|Novartis|Stand Up To Cancer October 15 2018 Phase 2
NCT03553329 Completed Drug: dabrafenib Unresecable Stage IIIc or IV Melanoma Poitiers University Hospital June 2 2018 --
NCT03593993 Recruiting Procedure: Surgical Cohort Glioma|BRAF V600E|Pleomorphic Xantho-Astrocytoma|Glioblastoma Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins|Musella Foundation May 19 2018 --
NCT03340506 Recruiting Drug: dabrafenib|Drug: trametinib Melanoma|Non Small Cell Lung Cancer|Solid Tumor|Rare Cancers|High Grade Glioma Novartis Pharmaceuticals|Novartis December 28 2017 Phase 4

技术支持

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操作手册

如果有其他问题,请给我们留言。

  • * 必填项

Raf Signaling Pathway Map

Raf Inhibitors with Unique Features

相关Raf产品

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID