Dabrafenib (GSK2118436)

For research use only. Not for use in humans.

目录号:S2807

Dabrafenib (GSK2118436) Chemical Structure

CAS No. 1195765-45-7

Dabrafenib (GSK2118436)是一种突变型BRAFV600特异性抑制剂,无细胞试验中IC50为0.7 nM,作用于B-Raf(wt)和c-Raf效果分别低7和9倍。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1481.39 现货
RMB 733.64 现货
RMB 1056.75 现货
RMB 1394.46 现货
RMB 2235.84 现货
RMB 3261.37 现货
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客户使用Selleck生产的Dabrafenib (GSK2118436)发表文献158篇:

产品安全说明书

Raf抑制剂选择性比较

生物活性

产品描述 Dabrafenib (GSK2118436)是一种突变型BRAFV600特异性抑制剂,无细胞试验中IC50为0.7 nM,作用于B-Raf(wt)和c-Raf效果分别低7和9倍。
靶点
B-Raf (V600E) [3]
(Cell-free assay)
B-Raf [3]
(Cell-free assay)
C-Raf [3]
(Cell-free assay)
0.7 nM 5.2 nM 6.3 nM
体外研究

Dabrafenib对Raf激酶具有选择性,对B-Raf的活性比其它测试过的91%的激酶高400倍。 Dabrafenib抑制B-RafV600E激酶,导致ERK磷酸化降低和抑制细胞的增值,在特异性编码突变的B-RafV600E的癌细胞中细胞停滞在G1期。

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
M3XF[mtqdmG|ZTDBd5NigQ>? NFnacJFKdmirYnn0bY9vKG:oIF6teIVzdWmwYXygTIl{KHSjZ3fl[EBDNVKjZjDWOlAxTSCvdYThcpQh\XiycnXzd4VlKGmwIHLhZ5Vtd3[rcoXzJIlv\mWldHXkJIlve2WldDDj[YxteyClbz3lfJBz\XO|aX7nJGNFSzN5IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKGKrb4Tpcplt[XSnZD3NSWsheHKxdHXpckBxcG:|cHjvdplt[XSrb36gZpkhSWyyaHHTZ5Jm\W5iYYPzZZkhf2m2aDDJR|UxKG:oIECuNFAxPyEQvF2= NXLZPXRXOjR7MEC2O|M>
SK-MEL-28 MmPhT4lv[XOnIFHzd4F6 NUHwOIFmOSCq NG\IPZpKdmirYnn0bY9vKG:oIFKtVoFnKFZ4MEDFJI12fGGwdDDpckBpfW2jbjDTT{1OTUxvMkigZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hTVKNIIDoc5NxcG:{eXzheIlwdiC5aYToJGlEPTBib3[gNE4xODRizszN MX6yOFkxODZ5Mx?=
HepG2 M1vUR2tqdmG|ZTDBd5NigQ>? NETnUWhKdmirYnn0bY9vKG:oIFKtVoFnKFZ4MEDFJI12fGGwdDDpckBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDFVmsheGixc4Doc5J6dGG2aX;uJJdqfGhiSVO1NEBw\iByLkCwOEDPxE1? NET5PGUzPDlyME[3Ny=>
COLO205 NInXNJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\LfJBKdmirYnn0bY9vKG:oIHj1cYFvKEORTF:yNFUh[2WubDDwdo9tcW[ncnH0bY9vKHerdHigTWM2OCCxZjCwMlAxPyEQvF2= MWqyOFkxODZ5Mx?=
HepG2 MoO3SpVv[3Srb36gRZN{[Xl? NXTBbpAxPDVibXnu NVvHW2lWTE2VTx?= MmW3TY5pcWKrdHnvckBw\iCDbHu1JIlvKFSJRj3i[ZRiNXO2aX31cIF1\WRiaIXtZY4hUGWyR{KgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hW22jZEKgdIhwe3Cqb4L5cIF1cW:wIITy[YF1\WRiZn;yJFQ2KG2rboOgdJJqd3JidH:gWGdHNWKndHGgd5RqdXWuYYTpc44hdWWjc4Xy[YQh[W[2ZYKgOlAhdWmwczDifUBw\Hm|c3X5JIJtd3Ric3Phco5meiCjbnHsfZNqeyC5aYToJGlEPTBib3[gN{44KM7:TR?= NF3LcIwzPDlyME[3Ny=>
HFF MnvQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmr2NVAh|ryP M3G4fFczKGh? MWPEUXNQ NFn2OFFKdmirYnn0bY9vKG:oIIDyc4xq\mW{YYTpc44hd2ZiaIXtZY4hUE[IIHPlcIx{KGijcnLvdolv\yC5aXzkJJR6eGViQj3SZYYhf2m2aDDJR|UxKG:oIEOg{txO MWGyN|g1PDB|OB?=
SK-MEL-28 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLsNVAh|ryP M4HtbFczKGh? M{DUN2ROW09? NVLTWGdqUW6qaXLpeIlwdiCxZjDCMXJi\iCYNkCwSUBufXSjboSt[JJqfmWwIGPLMW1GVC1{ODDj[YxtKHC{b3zp[oVz[XSrb36ge4l1cCCLQ{WwJI9nKDBwMESzJO69VQ>? Mkm0NlM5PDRyM{i=
A375P-F11 M3rUdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYS2VW1EOTBizszN Mkf5O|IhcA>? M2OxWGROW09? M33jWWlvcGmkaYTpc44hd2ZiQj3SZYYhXjZyMFWgcZV1[W62LXTybZZmdiCDM{e1VE1HOTFiY3XscEBxem:uaX\ldoF1cW:wIIfpeIghUUN3MDDv[kAxNjB5MTFOwG0> NFHL[G4zOzh2NECzPC=>
MALME-3M NWTNfVVET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknXNVAh|ryP NEHpbGs4OiCq NEPmdpJFVVOR NVnm[ll3UUN3ME2xJI5O MmPQNlM5PDRyM{i=
UACC-62 M3[0O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrONGgyOCEQvF2= NVTMPWVvPzJiaB?= M4n1WGROW09? MUnJR|UxRTFibl2= MonNNlM5PDRyM{i=
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SK-MEL-28 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\1NVAh|ryP MmexO|IhcA>? MYfEUXNQ MYHJR|UxRTNibl2= MV:yN|g1PDB|OB?=
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UACC-257 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnvSIwxOTBizszN MkL1O|IhcA>? MkLsSG1UVw>? NFLIPVhKSzVyPU[gcm0> MVuyN|g1PDB|OB?=
Colo 205 MofDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2iwZlExKM7:TR?= M2\0[|czKGh? NUS0O|ZVTE2VTx?= NInBVGVKSzVyPUegcm0> MV6yN|g1PDB|OB?=
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SH-4 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPNNVAh|ryP MYS3NkBp MX3EUXNQ M{P2PGlEPTB;ODDuUS=> M{niclI{QDR2MEO4
A101D MkPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHLR5ZKOTBizszN MWe3NkBp NFj2VoZFVVOR NILh[|RKSzVyPUmgcm0> NELpU2IzOzh2NECzPC=>
ES-2 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\NT3VPOTBizszN MV63NkBp MlL1SG1UVw>? Mlq1TWM2OD13MzDuUS=> NITkZnczOzh2NECzPC=>
HT-29 NWDDcJZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvRNVAh|ryP MX:3NkBp NHzuWW5FVVOR MYTJR|UxRTZ4IH7N MoXuNlM5PDRyM{i=
SW1417 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzONVAh|ryP NF33e5U4OiCq M{TaUGROW09? NIjK[3JKSzVyPUG1PEBvVQ>? NYXjeHJ3OjN6NESwN|g>
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GCT Mmj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVGxNEDPxE1? M1z3WVczKGh? NV\kS3RITE2VTx?= M4fmPGlEPTB;MUCg{txO MX2yN|g1PDB|OB?=
WM-115 NES0VHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDlNVAh|ryP M3LBUVczKGh? M1ruOWROW09? MYTJR|UxRTVibl2= MYiyN|g1PDB|OB?=
YUMAC MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPLPGQyOCEQvF2= MnLXO|IhcA>? NUC1eHh2TE2VTx?= NY\5SJJUUUN3ME21JI5O MnLSNlM5PDRyM{i=
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NCI-H508 M{izS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTZNVAh|ryP NIiwbG44OiCq MXnEUXNQ M2[zc2lEPTB;MUCg{txO M4TYSVI{QDR2MEO4
MDA-MB-231 M13Fbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnaTZNlOTBizszN NF;RW5Y4OiCq Mmi2SG1UVw>? MXnJR|UxRTFyIN88US=> NILnO5gzOzh2NECzPC=>
SW756 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XRVVExKM7:TR?= MY[3NkBp NETlVlJFVVOR Ml3STWM2OD1zMDFOwG0> Mn\UNlM5PDRyM{i=
SW-837 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vle|ExKM7:TR?= NULQWHJmPzJiaB?= M4TXdGROW09? MmrMTWM2OD1zMDFOwG0> Mn;zNlM5PDRyM{i=
UMUC-3 M3jNSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFu1ZmYyOCEQvF2= MlPuO|IhcA>? NEXGUnRFVVOR Ml:5TWM2OD1zMDFOwG0> MnvtNlM5PDRyM{i=
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A549 MkWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\3OHMyOCEQvF2= NV[5SHR6PzJiaB?= MnfTSG1UVw>? NELFcHBKSzVyPUGwJO69VQ>? Ml3DNlM5PDRyM{i=
SHP-77 M2fpT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXOxNEDPxE1? NH;uZXU4OiCq MorZSG1UVw>? NWXDW2R4UUN3ME2xNEDPxE1? NXjpO|F2OjN6NESwN|g>
SW480 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjwNVAh|ryP Mof3O|IhcA>? MkW1SG1UVw>? MlPlTWM2OD1zMDFOwG0> M4n4eFI{QDR2MEO4
DLD-1 NUG1VVAzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfyNVAh|ryP NFv3d3I4OiCq NHLxNo9FVVOR MmnQTWM2OD1zMDFOwG0> NH\YNFUzOzh2NECzPC=>
HCT-116 MnzkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPWT2Q1OTBizszN Ml24O|IhcA>? NU\ic|Z5TE2VTx?= NEmxOYNKSzVyPUGwJO69VQ>? NF;zSpgzOzh2NECzPC=>
NCI-H747 NWD2UZdtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYOyVYc4OTBizszN NUG2cWdNPzJiaB?= NWO2[G9ETE2VTx?= MYDJR|UxRTFyIN88US=> NYGwN3BpOjN6NESwN|g>
T-84 Mn3mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TLRlExKM7:TR?= NIfMfIY4OiCq NIDDdm1FVVOR NH7rT4ZKSzVyPUGwJO69VQ>? NHTQXmEzOzh2NECzPC=>
NCI-H460 NVPadnB3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTPNVAh|ryP MlruO|IhcA>? MX7EUXNQ NWPwPZdnUUN3ME2xNEDPxE1? NF\2e|AzOzh2NECzPC=>
Calu-6 NX;q[Xo2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVexNEDPxE1? NYjtd3RlPzJiaB?= M{Lp[GROW09? MVXJR|UxRTFyIN88US=> NVPIbXRTOjN6NESwN|g>
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LS1034 NEnPUJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1ThT|ExKM7:TR?= NXe0V2x5PzJiaB?= Mlz3SG1UVw>? NIrscJVKSzVyPUGwJO69VQ>? NXi2cppHOjN6NESwN|g>
CHP-212 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPsS2RvOTBizszN MkfJO|IhcA>? MnHTSG1UVw>? MXnJR|UxRTFyIN88US=> NXiyNmRVOjN6NESwN|g>
SK-N-AS MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;SZlJOOTBizszN NWPtTWs2PzJiaB?= MU\EUXNQ NIfzPWRKSzVyPUGwJO69VQ>? NW\Xd3lsOjN6NESwN|g>
BFTC-905 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPXNVAh|ryP MWi3NkBp M1H0eGROW09? NIHKXYNKSzVyPUGwJO69VQ>? NY\NSo1lOjN6NESwN|g>
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Kato III MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF[yTFMyOCEQvF2= MmPzO|IhcA>? MnHqSG1UVw>? MWHJR|UxRTFyIN88US=> MVeyN|g1PDB|OB?=
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KM-12 M{Hj[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzke3YyOCEQvF2= NEDnPVE4OiCq NGeyZoJFVVOR MU\JR|UxRTFyIN88US=> Mn7BNlM5PDRyM{i=
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MiaPaCa Mm\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWKxNEDPxE1? Mn3xO|IhcA>? M3zZXmROW09? MWnJR|UxRTFyIN88US=> Mor3NlM5PDRyM{i=
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NCI-ADR/RES Mn7nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3XVIxpOTBizszN MnXOO|IhcA>? NVu5flA{TE2VTx?= MWHJR|UxRTFyIN88US=> M{jYUlI{QDR2MEO4
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NCI-H82 NV\penZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlm3NVAh|ryP M4XVVVczKGh? M2\LOmROW09? Ml\FTWM2OD1zMDFOwG0> MUCyN|g1PDB|OB?=
NCI-N87 MmmzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3nNVAh|ryP NXqxeYVIPzJiaB?= MkD4SG1UVw>? NWrKN2ZDUUN3ME2xNEDPxE1? Ml\NNlM5PDRyM{i=
NCI-H146 Mm\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfhdINZOTBizszN M2fFflczKGh? MWfEUXNQ MXTJR|UxRTFyIN88US=> MWmyN|g1PDB|OB?=
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NCI-H187 MlHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3S4clExKM7:TR?= NIDwWYE4OiCq M1vRO2ROW09? NGnG[IJKSzVyPUGwJO69VQ>? MkflNlM5PDRyM{i=
NCI-H209 MoniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jBOlExKM7:TR?= MWi3NkBp NVnwblBITE2VTx?= NUXFZnVYUUN3ME2xNEDPxE1? Ml76NlM5PDRyM{i=
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NCI-H358 NUnaVVFNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEmzZlMyOCEQvF2= MoTpO|IhcA>? NInpUpRFVVOR M2\sNmlEPTB;MUCg{txO NGPpUXUzOzh2NECzPC=>
NCI-H520 NWT2OIl1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXyxNEDPxE1? MW[3NkBp MXLEUXNQ MnvJTWM2OD1zMDFOwG0> NU\NOZhPOjN6NESwN|g>
NCI-H526 NV;nTWlLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUCxSY1lOTBizszN MX:3NkBp NVvaeo5UTE2VTx?= MWTJR|UxRTFyIN88US=> NHK0bXozOzh2NECzPC=>
NCI-H630 MnPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUGxNEDPxE1? NHz1WG44OiCq NH\jdVdFVVOR M1T3bGlEPTB;MUCg{txO MY[yN|g1PDB|OB?=
NCI-H661 M1;qNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTkUpMyOCEQvF2= MlfkO|IhcA>? MnjqSG1UVw>? NVvMc3VqUUN3ME2xNEDPxE1? NH\FdHozOzh2NECzPC=>
NCI-H716 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2POT|ExKM7:TR?= M3foWVczKGh? M2HIcGROW09? NWD4RVhEUUN3ME2xNEDPxE1? NFfQZ4czOzh2NECzPC=>
NCI-H1563 MnmzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzkR3hzOTBizszN NID2V3Y4OiCq MnXaSG1UVw>? M1PYc2lEPTB;MUCg{txO NIHYOIozOzh2NECzPC=>
NCI-H1792 M2P0dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnVXW4yOCEQvF2= Mnu0O|IhcA>? NEnHWolFVVOR MmDpTWM2OD1zMDFOwG0> NITUVIMzOzh2NECzPC=>
NCI-H2030 M3;iV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV:xNEDPxE1? MoS5O|IhcA>? MXnEUXNQ NYnuV3hCUUN3ME2xNEDPxE1? MoDWNlM5PDRyM{i=
NCI-H2052 NIHkT3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnG3NVAh|ryP NU\NNW1iPzJiaB?= MYPEUXNQ NWPlfWVLUUN3ME2xNEDPxE1? NGn6V5IzOzh2NECzPC=>
NCI-H2122 NGPETZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV6xNEDPxE1? MkezO|IhcA>? Mk[3SG1UVw>? Mn3BTWM2OD1zMDFOwG0> MlfMNlM5PDRyM{i=
NCI-H2228 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUGxNEDPxE1? NYDCVmxTPzJiaB?= M330ZWROW09? M2DMVmlEPTB;MUCg{txO MWKyN|g1PDB|OB?=
OE-19 NIi5SWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY[xNEDPxE1? NELpNHc4OiCq NF\F[XlFVVOR NXyw[|RrUUN3ME2xNEDPxE1? NG\ydlMzOzh2NECzPC=>
OE-21 NFuzR21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LLNFExKM7:TR?= NGXRfHA4OiCq NXPwOms4TE2VTx?= NXnhS4s5UUN3ME2xNEDPxE1? M{[xcVI{QDR2MEO4
OE-33 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVixNEDPxE1? MlrSO|IhcA>? NUnycZNZTE2VTx?= NV72NIhrUUN3ME2xNEDPxE1? MmX4NlM5PDRyM{i=
OVCAR-3 NYKyNodwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nlblExKM7:TR?= NGXzUVA4OiCq NYrTUWNnTE2VTx?= NHrJ[ZhKSzVyPUGwJO69VQ>? MVyyN|g1PDB|OB?=
OVCAR-4 M3u3S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3q1d|ExKM7:TR?= M2DNWVczKGh? Ml;xSG1UVw>? NG\0ZZRKSzVyPUGwJO69VQ>? NFfGZ2kzOzh2NECzPC=>
OVCAR-5 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHrNVAh|ryP MVW3NkBp NGD2Rm1FVVOR NUTBXXFjUUN3ME2xNEDPxE1? MofyNlM5PDRyM{i=
P3HR-1 NWHldZBmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV6xNEDPxE1? M2HvTlczKGh? NHLRRWdFVVOR NVLWepdkUUN3ME2xNEDPxE1? NGqyfGIzOzh2NECzPC=>
PC-3 Mn;wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYO1cJRIOTBizszN M3;EW|czKGh? NFrscYFFVVOR MnraTWM2OD1zMDFOwG0> MUWyN|g1PDB|OB?=
Raji M2LMcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDVdFUyOCEQvF2= M1;jb|czKGh? NGPhVpRFVVOR MWrJR|UxRTFyIN88US=> MnP1NlM5PDRyM{i=
RD NUjLbHAyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3uzOlExKM7:TR?= M1TvS|czKGh? NXHBe|NMTE2VTx?= NIPwR2pKSzVyPUGwJO69VQ>? MV:yN|g1PDB|OB?=
RD-ES NETRZ4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHuUFJ3OTBizszN MnfRO|IhcA>? M{jUXmROW09? NIHWempKSzVyPUGwJO69VQ>? NU\VdYtmOjN6NESwN|g>
RL NH;iU4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHaNVAh|ryP MUm3NkBp M1rTS2ROW09? NVPBd21VUUN3ME2xNEDPxE1? NF;hNVEzOzh2NECzPC=>
SaOS2 NY\MeHlyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PMeFExKM7:TR?= MY[3NkBp MnnaSG1UVw>? NIPMZ4hKSzVyPUGwJO69VQ>? NHToflQzOzh2NECzPC=>
SCC-9 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDmWI4yOCEQvF2= M3vBT|czKGh? M1zuPGROW09? MWjJR|UxRTFyIN88US=> NX\1bJhVOjN6NESwN|g>
SCC-12 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\jdlExKM7:TR?= MmXDO|IhcA>? MUPEUXNQ MX7JR|UxRTFyIN88US=> NHnOO4MzOzh2NECzPC=>
SCC-13 NVPqfVR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnp[|lbOTBizszN NHzzR5A4OiCq NFPLXGhFVVOR MY\JR|UxRTFyIN88US=> M4rQUFI{QDR2MEO4
SCC-15 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEO5UFQyOCEQvF2= NFfWc5k4OiCq NFzj[lZFVVOR M3i5S2lEPTB;MUCg{txO NXSwRlZ7OjN6NESwN|g>
SCC-25 NIXCdJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3j1dVExKM7:TR?= M3izfFczKGh? NUT6ZmdjTE2VTx?= MYrJR|UxRTFyIN88US=> NE\TUJozOzh2NECzPC=>
SCLC-3 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fsd|ExKM7:TR?= MWS3NkBp NYX1cZN4TE2VTx?= MVjJR|UxRTFyIN88US=> NGPJSowzOzh2NECzPC=>
SF-268 NEnVRYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETrTZYyOCEQvF2= NWLKV4llPzJiaB?= MWPEUXNQ MkTrTWM2OD1zMDFOwG0> MoD6NlM5PDRyM{i=
SF-295 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmD0NVAh|ryP M2DiblczKGh? MlvaSG1UVw>? M4PJeWlEPTB;MUCg{txO NXW4[HJFOjN6NESwN|g>
SJRH30 MoG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;sNVAh|ryP M1PQcVczKGh? NXn0XoxpTE2VTx?= MVLJR|UxRTFyIN88US=> NVfpOGtDOjN6NESwN|g>
SK-BR-3 NWnaSnM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\vUY0yOCEQvF2= Mn\NO|IhcA>? NH3ZTldFVVOR MorkTWM2OD1zMDFOwG0> NELHdG4zOzh2NECzPC=>
SK-LMS-1 NWrxfGNHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVyxNEDPxE1? NVziZVdlPzJiaB?= MoPqSG1UVw>? M1zPV2lEPTB;MUCg{txO M3G0SFI{QDR2MEO4
SK-N-DZ MkDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV2xNEDPxE1? NXH4TFFCPzJiaB?= NULxZ5NYTE2VTx?= M3;zbGlEPTB;MUCg{txO NVHZZ5h{OjN6NESwN|g>
SK-N-F1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjWNVAh|ryP MlPTO|IhcA>? NVLG[WVjTE2VTx?= MkX3TWM2OD1zMDFOwG0> MonSNlM5PDRyM{i=
SKOV-3 M3\tcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXqNVAh|ryP M3\QOFczKGh? MVHEUXNQ NHfZc4hKSzVyPUGwJO69VQ>? M2roclI{QDR2MEO4
SK-UT-1 NY\hTXFMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXexNEDPxE1? M3zGe|czKGh? NYf5S3M3TE2VTx?= M1jRUGlEPTB;MUCg{txO NYTnSIIyOjN6NESwN|g>
SN12C MljWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWSxNEDPxE1? MU[3NkBp M1;Ee2ROW09? NFzqc4lKSzVyPUGwJO69VQ>? NWHzcWtsOjN6NESwN|g>
SNB-19 NWfXdpIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVOycpA5OTBizszN M4fBWVczKGh? NVS5bIhKTE2VTx?= MUXJR|UxRTFyIN88US=> NYX3e5pXOjN6NESwN|g>
SNU-5 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVGzSZRzOTBizszN MXe3NkBp MYHEUXNQ MkfHTWM2OD1zMDFOwG0> NY\RNY1vOjN6NESwN|g>
SNU-16 MnfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnWN45KOTBizszN M3XmV|czKGh? M1TZc2ROW09? NHjmcmhKSzVyPUGwJO69VQ>? NGPFbGIzOzh2NECzPC=>
SNU-398 NX34[I95T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnuZWVtOTBizszN M{[w[|czKGh? MWLEUXNQ NVHWZ4pXUUN3ME2xNEDPxE1? M3XkdVI{QDR2MEO4
SNU-449 MkjJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofaNVAh|ryP MnG2O|IhcA>? M4DoPGROW09? NYXPd5NOUUN3ME2xNEDPxE1? MmD4NlM5PDRyM{i=
SR M3XJNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfzNVAh|ryP MYG3NkBp NUDkdWI5TE2VTx?= MlTZTWM2OD1zMDFOwG0> NVnhOWFrOjN6NESwN|g>
ST486 NULDNmtYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LXOlExKM7:TR?= M{jYT|czKGh? NFLJfVFFVVOR MYnJR|UxRTFyIN88US=> MoTpNlM5PDRyM{i=
SW579 M1HESmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYWxNEDPxE1? MkD0O|IhcA>? NFXGT4FFVVOR NVTXTGFCUUN3ME2xNEDPxE1? NHXZRlYzOzh2NECzPC=>
SW684 M1:zTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITBZnYyOCEQvF2= Mn7vO|IhcA>? MmKySG1UVw>? M2HZc2lEPTB;MUCg{txO MUCyN|g1PDB|OB?=
SW-780 Moj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfxNVAh|ryP NVS2VoZbPzJiaB?= NFq3fWRFVVOR NUi5d25uUUN3ME2xNEDPxE1? MWqyN|g1PDB|OB?=
SW900 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYmxNEDPxE1? NWruT2VYPzJiaB?= NH;wV3VFVVOR NIXFfJFKSzVyPUGwJO69VQ>? MmLGNlM5PDRyM{i=
SW1088 NHS3foJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHCOmUyOCEQvF2= NEHDN5k4OiCq MYLEUXNQ M2rFNWlEPTB;MUCg{txO NYG5NXc5OjN6NESwN|g>
SW1463 Mn\3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\WT25SOTBizszN MlfJO|IhcA>? M2n3[mROW09? MWPJR|UxRTFyIN88US=> NXexdnkxOjN6NESwN|g>
SW1990 M3PmVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnH2NVAh|ryP MWK3NkBp NFnneIJFVVOR MYDJR|UxRTFyIN88US=> NHfMb5EzOzh2NECzPC=>
T47D MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVmxNEDPxE1? NGrRXJU4OiCq MX\EUXNQ MVXJR|UxRTFyIN88US=> MkPqNlM5PDRyM{i=
TE381.T MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjnNVAh|ryP NGH6dlU4OiCq MnjLSG1UVw>? MmTpTWM2OD1zMDFOwG0> MkizNlM5PDRyM{i=
TK-10 NHLobnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVqxNEDPxE1? M{nSUlczKGh? MnTWSG1UVw>? M4XRc2lEPTB;MUCg{txO MWCyN|g1PDB|OB?=
U2OS NVrJbGhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnWNXpCOTBizszN M1vGSlczKGh? Ml7HSG1UVw>? NUfVRXFFUUN3ME2xNEDPxE1? NEXFOGUzOzh2NECzPC=>
U251 NH65UpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPBNVAh|ryP NIO1d4M4OiCq MWnEUXNQ Ml3STWM2OD1zMDFOwG0> MXOyN|g1PDB|OB?=
UACC-812 MlrZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPROngyOCEQvF2= NX7DSpNqPzJiaB?= MVTEUXNQ NIrkT2ZKSzVyPUGwJO69VQ>? M2\GblI{QDR2MEO4
YAPC NYe2UHh7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjYNVAh|ryP MomzO|IhcA>? NGPoPWVFVVOR MmK0TWM2OD1zMDFOwG0> MUGyN|g1PDB|OB?=
ZR-75-1 M{\aXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PtNVExKM7:TR?= MYC3NkBp NIXrSoFFVVOR MkTsTWM2OD1zMDFOwG0> NVXpfG1nOjN6NESwN|g>
A375 M3\oWmZ2dmO2aX;uJIF{e2G7 NXvVSldXOS5{IN88US=> M3L3cFQhcA>? NV3QcnJkTE2VTx?= MXTJcohq[mm2aX;uJI9nKHCqb4PwbI9zgWyjdHnvckBw\iCPRVusJGVTUyxiYX7kJHM3WA>? M2foT|IzOzh7NEex
YUSIT1 M2DEOmZ2dmO2aX;uJIF{e2G7 MmL4SG1UVw>? MWjy[YR2[2WmIIPlcpNqfGm4aYT5JJdqfGhiSVO1NEA,KDBwNTFOwG0> MXeyNlM5QTR5MR?=
MeWo M{\MR2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MknqSG1UVw>? NEHtb2lKSzVyIE2gPVg4KG6P M1u1e|I3ODF6NUK0
WiDr NUHsXXBiT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnPVSG1UVw>? M37tU2lEPTBiPTC3OkBvVQ>? MUKyOlAyQDV{NB?=
Colo-205 NVLVfY9TTnWwY4Tpc44h[XO|YYm= MYKxJO69VQ>? M2TKbVQh\A>? MkLGSG1UVw>? M{SzfWlv\HWlZXSgZUBpcWeqbImgZ49ueGG{YXLs[UBkd22yYXP0bY9vKHCqZX7veJlx\Q>? MmXONlU{QDFzNUK=
RBW-1 MmftSpVv[3Srb36gZZN{[Xl? MWqxJO69VQ>? MUfEUXNQ Mmq1Uo8hemWmdXP0bY9vKG:oIF3lb{AyNzJicHjvd5Bpd3K7bHH0bY9v NIq5bnMzPDh6NU[5NC=>
RBO-1 NV\jNo1KTnWwY4Tpc44h[XO|YYm= MVOxJO69VQ>? NX\LV3ZwTE2VTx?= M{Lrd2lvcGmkaYTpc44hd2ZiTXXrJFEwOiCyaH;zdIhwenmuYYTpc44> MnXnNlQ5QDV4OUC=
RBO-2 MXPGeY5kfGmxbjDhd5NigQ>? M1rW[|Eh|ryP M2rCTGROW09? M3KzR2lvcGmkaYTpc44hd2ZiIF3lb{AyNzJicHjvd5Bpd3K7bHH0bY9v M3PncVI1QDh3Nkmw
RBOW MWrGeY5kfGmxbjDhd5NigQ>? NF3LeVgyKM7:TR?= NXXOc|dqTE2VTx?= MlvtTY5pcWKrdHnvckBw\iBiTXXrJFEwOiCyaH;zdIhwenmuYYTpc44> NELsOFAzPDh6NU[5NC=>
M257 MmCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPhe3BUOTByIH7N NEXGWIU4OiCq NVHTVmV4TG:nczDuc5QhcW6qaXLpeEBxem:uaX\ldoF1cW:wIH;mJG0zPTdiY3XscEBp[XKkb4XybY5oKHerbHSgeJlx\SCEUlHG M{fLNFI{OzF5NES2
LCP NHLVOmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvIUVMyODBibl2= NHixdoI4OiCq NGniVGdKdmirYnn0bY9vKG:oIIDyc4xq\mW{YYTpc44hd2ZiTFPQJINmdGxiaHHyZo92emmwZzDCVmFHKFZ4MEDSJI12fGGwdHH0bY9v NGn1V40zOzNzN{S0Oi=>
WM266 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fyOVExOCCwTR?= M{XiWFczKGh? MkX1TY5pcWKrdHnvckBw\iCycn;sbYZmemG2aX;uJI9nKFePMk[2JINmdGxiaHHyZo92emmwZzDCVmFHKFZ4MEHEJI12fGGwdHH0bY9v NWrBUZdNOjN|MUe0OFY>
M257 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fvTVExOCCwTR?= MlTlO|IhcA>? MkCySI9meyCwb4SgbY5pcWKrdDDFVmsyNTJicHjvd5Bpd3K7bHH0bY9vKGmwIF2yOVch[2WubDDoZZJjd3W{aX7nJJdqdGRidInw[UBDWkGI NUi1O3NPOjN|MUe0OFY>
LCP NVfUWohHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XSV|ExOCCwTR?= NXPkWphTPzJiaB?= MkTwTY5pcWKrdDDFVmsyNTJicHjvd5Bpd3K7bHH0bY9vKGmwIFzDVEBk\WyuIHjhdoJwfXKrbnegRnJCTiCYNkCwVkBufXSjboTheIlwdg>? MUmyN|MyPzR2Nh?=
WM266 NXSwdWJFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4D1NFExOCCwTR?= NITjRmM4OiCq NITzeINKdmirYnn0JGVTUzFvMjDwbI9{eGixconsZZRqd25iaX6gW20zPjZiY3XscEBp[XKkb4XybY5oKEKUQV[gWlYxOERibYX0ZY51[XSrb36= MkXWNlM{OTd2NE[=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pMEK / pERK / ERK; 

PubMed: 31158244     


Cell lines as shown were treated with dabrafenib, over a dose range, for 1 hour. UT = untransfected.  Expression and/or phosphorylation of the indicated proteins were assessed by immunoblot.

p-S6 / p-AKT308 / p-AKT473; 

PubMed: 24735930     


Western blot analysis of phosphorylated proteins in MAPK and the PI3K-AKT pathway after 24 hours exposure to increasing concentrations of dabrafenib.

β-catenin; 

PubMed: 29167314     


HT-29 cells were treated with BRAF inhibitors Dabrafenib (2 μM), GDC-0879 (4 μM) or Vemurafenib (2 μM) for indicated times. The whole cell lysates were used for western blot with indicated antibodies.

31158244 24735930 29167314
Growth inhibition assay
IC50; 

PubMed: 24735930     


A panel of 23 BRAF(V600) mutant human melanoma cell lines was treated with serial dilutions (1-10,000 nM) of dabrafenib (A) for 72-120 hours to assess cell viability. The bars represent the average IC50 value of two or more independent experiments in duplicates and the error bars represent the SEM. 

24735930
体内研究 Dabrafenib(口服)抑制B-RafV600E突变的黑色素瘤(A375P)的生长,在免疫受损小鼠中皮下注射结肠癌(Colo205),Dabrafenib(口服)同样能抑制肿瘤生长。 [1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

溶解度 (25°C)

体外 DMSO 30 mg/mL (57.74 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
2% DMSO+45% PEG 300+2% Tween 80+ddH2O
5 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 519.56
化学式

C23H20F3N5O2S2

CAS号 1195765-45-7
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04452877 Not yet recruiting Drug: Dabrafenib|Drug: Trametinib Carcinoma Non-Small-Cell Lung Novartis Pharmaceuticals|Novartis August 31 2020 Phase 2
NCT04059224 Recruiting Drug: Trametinib|Drug: Dabrafenib Stage IV Melanoma|Stage III Melanoma Universitair Ziekenhuis Brussel January 28 2019 Phase 2
NCT03668431 Recruiting Drug: Dabrafenib|Drug: Trametinib|Drug: PDR001 Metastatic Colorectal Cancer Massachusetts General Hospital|Novartis|Stand Up To Cancer October 15 2018 Phase 2
NCT03553329 Completed Drug: dabrafenib Unresecable Stage IIIc or IV Melanoma Poitiers University Hospital June 2 2018 --
NCT03593993 Recruiting Procedure: Surgical Cohort Glioma|BRAF V600E|Pleomorphic Xantho-Astrocytoma|Glioblastoma Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins|Musella Foundation May 19 2018 --

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

Raf Signaling Pathway Map

Raf Inhibitors with Unique Features

相关Raf产品

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID