Dabrafenib (GSK2118436)

For research use only. Not for use in humans.

目录号:S2807

Dabrafenib (GSK2118436) Chemical Structure

Molecular Weight(MW): 519.56

Dabrafenib (GSK2118436)是一种突变型BRAFV600特异性抑制剂,无细胞试验中IC50为0.7 nM,作用于B-Raf(wt)和c-Raf效果分别低7和9倍。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1481.39 现货
RMB 733.64 现货
RMB 1056.75 现货
RMB 1394.46 现货
RMB 2235.84 现货
RMB 3261.37 现货
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客户使用Selleck生产的Dabrafenib (GSK2118436)发表文献150篇:

产品安全说明书

Raf抑制剂选择性比较

生物活性

产品描述 Dabrafenib (GSK2118436)是一种突变型BRAFV600特异性抑制剂,无细胞试验中IC50为0.7 nM,作用于B-Raf(wt)和c-Raf效果分别低7和9倍。
靶点
B-Raf (V600E) [3]
(Cell-free assay)
B-Raf [3]
(Cell-free assay)
C-Raf [3]
(Cell-free assay)
0.7 nM 5.2 nM 6.3 nM
体外研究

Dabrafenib对Raf激酶具有选择性,对B-Raf的活性比其它测试过的91%的激酶高400倍。 Dabrafenib抑制B-RafV600E激酶,导致ERK磷酸化降低和抑制细胞的增值,在特异性编码突变的B-RafV600E的癌细胞中细胞停滞在G1期。

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
M3G4[2tqdmG|ZTDBd5NigQ>? NWmySIo3UW6qaXLpeIlwdiCxZjDOMZRmem2rbnHsJGhqeyC2YXfn[YQhSi2UYX[gWlYxOEVibYX0ZY51KGW6cILld5Nm\CCrbjDiZYN2dG:4aYL1d{Bqdm[nY4Tl[EBqdnOnY4SgZ4VtdHNiY3:t[ZhxemW|c3nu[{BETEN|NzDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiCkaX;0bY56dGG2ZXStUWVMKHC{b4TlbY4heGixc4Doc5J6dGG2aX;uJIJ6KEGucHjhV4Nz\WWwIHHzd4F6KHerdHigTWM2OCCxZjCwMlAxODdizszN NXPvO|hNOjR7MEC2O|M>
SK-MEL-28 M1jSZ2tqdmG|ZTDBd5NigQ>? M37sZVEhcA>? M{Xo[GlvcGmkaYTpc44hd2ZiQj3SZYYhXjZyMFWgcZV1[W62IHnuJIh2dWGwIGPLMW1GVC1{ODDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBGWkticHjvd5Bpd3K7bHH0bY9vKHerdHigTWM2OCCxZjCwMlAxPCEQvF2= NH3tN4gzPDlyME[3Ny=>
HepG2 NI\pSWlMcW6jc3WgRZN{[Xl? MXHJcohq[mm2aX;uJI9nKEJvUnHmJHY3ODCHIH31eIFvfCCrbjDoeY1idiCKZYDHNkBk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiCHUlugdIhwe3Cqb4L5cIF1cW:wIIfpeIghUUN3MDDv[kAxNjByNDFOwG0> MXyyOFkxODZ5Mx?=
COLO205 MnzpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTiTY5pcWKrdHnvckBw\iCqdX3hckBEV0yRMkC1JINmdGxicILvcIln\XKjdHnvckB4cXSqIFnDOVAhd2ZiMD6wNFch|ryP NWWyXHc3OjR7MEC2O|M>
HepG2 NVXjTXZTTnWwY4Tpc44hSXO|YYm= M1X4TVQ2KG2rbh?= MXnEUXNQ MYjJcohq[mm2aX;uJI9nKEGua{WgbY4hXEeILXLleIEue3SrbYXsZZRm\CCqdX3hckBJ\XCJMjDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBUdWGmMjDwbI9{eGixconsZZRqd25idILlZZRm\CCob4KgOFUhdWmwczDwdolweiC2bzDUS2Yu[mW2YTDzeIlufWyjdHnvckBu\WG|dYLl[EBi\nSncjC2NEBucW6|IHL5JI9lgXO|ZYmgZoxwfCC|Y3HucoVzKGGwYXz5d4l{KHerdHigTWM2OCCxZjCzMlch|ryP M4K3XFI1QTByNkez
HFF NH;s[mhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYOxNEDPxE1? MnjmO|IhcA>? MYnEUXNQ MXTJcohq[mm2aX;uJI9nKHC{b3zp[oVz[XSrb36gc4YhcHWvYX6gTGZHKGOnbHzzJIhiemKxcnnu[{B4cWymIIT5dIUhSi2UYX[ge4l1cCCLQ{WwJI9nKDNizszN Mnn5NlM5PDRyM{i=
SK-MEL-28 NUXNc5J{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPue2FwOTBizszN M1j3S|czKGh? M3fUXWROW09? MmLlTY5pcWKrdHnvckBw\iCELWLh[kBXPjByRTDteZRidnRvZILpeoVvKFONLV3FUE0zQCClZXzsJJBzd2yrZnXyZZRqd25id3n0bEBKSzVyIH;mJFAvODR|IN88US=> M3;RVlI{QDR2MEO4
A375P-F11 M4LFbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW[xNEDPxE1? M4fwdVczKGh? MUDEUXNQ NELmTGFKdmirYnn0bY9vKG:oIFKtVoFnKFZ4MEDFJI12fGGwdD3kdol3\W5iQUO3OXAuTjFzIHPlcIwheHKxbHnm[ZJifGmxbjD3bZRpKEmFNUCgc4YhOC5yN{Gg{txO NYHYXI5xOjN6NESwN|g>
MALME-3M NIT6[5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrwfoQyOCEQvF2= MUC3NkBp MnnmSG1UVw>? Mof2TWM2OD1zIH7N NFfBW20zOzh2NECzPC=>
UACC-62 M3Hpdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGT1[G0yOCEQvF2= NETN[o44OiCq MUTEUXNQ MYnJR|UxRTFibl2= MWqyN|g1PDB|OB?=
C32TG NXr5PZh1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVi0VJRHOTBizszN MkfLO|IhcA>? M2iyemROW09? MXvJR|UxRTFibl2= M3;r[|I{QDR2MEO4
SK-MEL-1 M2fzVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\EWlExKM7:TR?= NUm4eFFZPzJiaB?= MYTEUXNQ M4LGUWlEPTB;MjDuUS=> NF\WZlYzOzh2NECzPC=>
M14 NVKydYhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3izd|ExKM7:TR?= MkTRO|IhcA>? MnSzSG1UVw>? MlriTWM2OD1{IH7N NWrGdYl5OjN6NESwN|g>
SK-MEL-28 NWn0e4RtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV:xNEDPxE1? MX:3NkBp MUjEUXNQ NWjxb2FtUUN3ME2zJI5O M1PjcVI{QDR2MEO4
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DU-4475 M4rKNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXOxNEDPxE1? M1vld|czKGh? M2fzV2ROW09? NVTTNXVIUUN3ME21JI5O MV:yN|g1PDB|OB?=
UACC-257 NXjXU5pXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rRNFExKM7:TR?= NH7zWFI4OiCq MnHFSG1UVw>? M1;KUGlEPTB;NjDuUS=> MXWyN|g1PDB|OB?=
Colo 205 MmP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFe2cXYyOCEQvF2= NUP2OHdrPzJiaB?= M2eydmROW09? MnT5TWM2OD15IH7N NIK0[XgzOzh2NECzPC=>
SK-MEL-3 M3S1Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3Wd2wyOCEQvF2= MnnZO|IhcA>? Mk\KSG1UVw>? M1fpNmlEPTB;NzDuUS=> MXWyN|g1PDB|OB?=
SH-4 MlHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXLOZkyOCEQvF2= NWHwdYZyPzJiaB?= MlrWSG1UVw>? MnHpTWM2OD16IH7N NYDFUFFuOjN6NESwN|g>
A101D MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zGOVExKM7:TR?= M3jocFczKGh? NYfiVmdGTE2VTx?= MWjJR|UxRTlibl2= NUjseo5{OjN6NESwN|g>
ES-2 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGO3XIEyOCEQvF2= MXe3NkBp MonHSG1UVw>? NF7Mc4tKSzVyPUWzJI5O NEHxTm4zOzh2NECzPC=>
HT-29 NWDSdoxRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWixNEDPxE1? Ml7iO|IhcA>? NYTXRm53TE2VTx?= NET3coxKSzVyPU[2JI5O MVWyN|g1PDB|OB?=
SW1417 MlHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnG4NVAh|ryP M2W5O|czKGh? NIm5cWtFVVOR MUnJR|UxRTF3ODDuUS=> Mof2NlM5PDRyM{i=
SW872 NEfPdJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{f1R|ExKM7:TR?= MWW3NkBp M4q0RmROW09? NVfFWnVuUUN3ME2zO|chdk1? NF3BNoMzOzh2NECzPC=>
RKO NX7obWJUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkP4NVAh|ryP MY[3NkBp NVHtOZdKTE2VTx?= NVnpVoZ1UUN3ME2yMlUzOiEQvF2= Ml3BNlM5PDRyM{i=
A673 M1LJemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLsNVAh|ryP NG\qWI44OiCq MYHEUXNQ M2jsUWlEPTB;MUCg{txO NVvIc|h3OjN6NESwN|g>
GCT MnXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYOxNEDPxE1? NGHRPW44OiCq M2qwN2ROW09? NIXiUHZKSzVyPUGwJO69VQ>? NUiw[|FEOjN6NESwN|g>
WM-115 MnnZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fXXVExKM7:TR?= MVG3NkBp M2TYbmROW09? M333Z2lEPTB;NTDuUS=> NFHWbGYzOzh2NECzPC=>
YUMAC MmLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nVXVExKM7:TR?= NXTPVHlMPzJiaB?= MnzVSG1UVw>? NH\JNolKSzVyPUWgcm0> MX[yN|g1PDB|OB?=
OV-90 M{fjbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDRe2kyOCEQvF2= MXm3NkBp MWHEUXNQ M4jVc2lEPTB;Mkmgcm0> M4m4T|I{QDR2MEO4
NCI-H508 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXKxNEDPxE1? NGjqTmE4OiCq MXzEUXNQ M2ThUmlEPTB;MUCg{txO MkfWNlM5PDRyM{i=
MDA-MB-231 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX36d5F7OTBizszN NYLyfIFZPzJiaB?= M{[yT2ROW09? MnnwTWM2OD1zMDFOwG0> M1nwOFI{QDR2MEO4
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SW-837 M{fwbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nyNVExKM7:TR?= NFWwUos4OiCq M{TqWmROW09? MV7JR|UxRTFyIN88US=> NVj6U|A3OjN6NESwN|g>
UMUC-3 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXWxNEDPxE1? MYq3NkBp MVTEUXNQ M1rVW2lEPTB;MUCg{txO NFTWPJEzOzh2NECzPC=>
LS-174T NF;QbmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LjXlExKM7:TR?= Mmn0O|IhcA>? M4HtWmROW09? NInFPG9KSzVyPUGwJO69VQ>? NF\ocnEzOzh2NECzPC=>
A549 NEnMb49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3S0OVExKM7:TR?= MmPPO|IhcA>? MV3EUXNQ M2e5dGlEPTB;MUCg{txO M1fQSFI{QDR2MEO4
SHP-77 M{XDTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nPd|ExKM7:TR?= M3THflczKGh? Mn3hSG1UVw>? MWTJR|UxRTFyIN88US=> M{jtZlI{QDR2MEO4
SW480 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{juV|ExKM7:TR?= M3q2bVczKGh? NWXmcIpbTE2VTx?= NULV[JNZUUN3ME2xNEDPxE1? M1;OT|I{QDR2MEO4
DLD-1 M3Xpfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHS4ZXgyOCEQvF2= MWe3NkBp MmP0SG1UVw>? M{ezbmlEPTB;MUCg{txO M1qzT|I{QDR2MEO4
HCT-116 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIm2S|kyOCEQvF2= NYjJXWlmPzJiaB?= NH;DVo5FVVOR MnjNTWM2OD1zMDFOwG0> NFPGcG0zOzh2NECzPC=>
NCI-H747 M{H2bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vQd|ExKM7:TR?= M1f2W|czKGh? M4jJV2ROW09? MUTJR|UxRTFyIN88US=> MmnPNlM5PDRyM{i=
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NCI-H460 MoGxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{H2d|ExKM7:TR?= MX[3NkBp MULEUXNQ NF23cGhKSzVyPUGwJO69VQ>? NUjyelQ5OjN6NESwN|g>
Calu-6 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLENVAh|ryP MorUO|IhcA>? MYrEUXNQ MmHHTWM2OD1zMDFOwG0> MojtNlM5PDRyM{i=
HCC-2998 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmr4NVAh|ryP Ml\rO|IhcA>? MXrEUXNQ MUXJR|UxRTFyIN88US=> MmPNNlM5PDRyM{i=
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CHP-212 NUK2[3dNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2D2OlExKM7:TR?= MVm3NkBp M2Hic2ROW09? MUnJR|UxRTFyIN88US=> MWGyN|g1PDB|OB?=
SK-N-AS MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV:xNEDPxE1? NEm3WWQ4OiCq NEHKVmNFVVOR NEiyb5VKSzVyPUGwJO69VQ>? M{PMclI{QDR2MEO4
BFTC-905 NIfOWFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLXSZRROTBizszN NXTR[mpJPzJiaB?= NYC2ZYh3TE2VTx?= NYe2Vpk4UUN3ME2xNEDPxE1? NVTqXoNvOjN6NESwN|g>
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RPMI-8226 NY\r[I1bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTCe2J2OTBizszN NUjDTXZ5PzJiaB?= MmS5SG1UVw>? NVPSPFhPUUN3ME2yOlMhdk1? MWGyN|g1PDB|OB?=
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ACHN M1ryW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW[xNEDPxE1? M3;Se|czKGh? MnS5SG1UVw>? MXPJR|UxRTJ7NDDuUS=> MmTkNlM5PDRyM{i=
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A172 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1K3R|ExKM7:TR?= NYPIOHoxPzJiaB?= MXLEUXNQ NHrwNWZKSzVyPUGwJO69VQ>? M3zGdFI{QDR2MEO4
A204 NX:5SmZIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzvUHZDOTBizszN NF6yUZA4OiCq M2LlemROW09? NUS5O4ZwUUN3ME2xNEDPxE1? NEPKUWczOzh2NECzPC=>
A427 MlXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XPZVExKM7:TR?= M2HmdlczKGh? M3ztS2ROW09? MkjuTWM2OD1zMDFOwG0> NX;LOIxvOjN6NESwN|g>
A431 NUe1PXNwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2CyOVExKM7:TR?= MnLKO|IhcA>? NYLXfpoyTE2VTx?= MXzJR|UxRTFyIN88US=> M2P3NFI{QDR2MEO4
A2780 NIDJd5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LmR|ExKM7:TR?= MV[3NkBp NGfvTmNFVVOR M4WwVmlEPTB;MUCg{txO M120elI{QDR2MEO4
ARH-77 M3LjUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLaRYNHOTBizszN NYDYXIx5PzJiaB?= NIHBW3JFVVOR MnW1TWM2OD1zMDFOwG0> M4\j[VI{QDR2MEO4
Be(2)C MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3tZYdtOTBizszN M1n6c|czKGh? M16xbGROW09? NHrIdZRKSzVyPUGwJO69VQ>? M3zZd|I{QDR2MEO4
BT-20 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVuxNEDPxE1? M4nke|czKGh? NXLhZmFKTE2VTx?= MXTJR|UxRTFyIN88US=> MYKyN|g1PDB|OB?=
BxPc3 NYDo[lhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PQblExKM7:TR?= M3P5O|czKGh? NV\kVFhwTE2VTx?= NH;3OHdKSzVyPUGwJO69VQ>? NHnwcHMzOzh2NECzPC=>
C-4 I MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI[wRlQyOCEQvF2= NUHubIFiPzJiaB?= M1PBcmROW09? NYr5e2t3UUN3ME2xNEDPxE1? NXTFTYRWOjN6NESwN|g>
C33A NIH0VGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrrNVAh|ryP M3HZZVczKGh? MVfEUXNQ NVW3WVdTUUN3ME2xNEDPxE1? NFz5ZpMzOzh2NECzPC=>
CAL-27 M{PSV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjVeGFPOTBizszN M4fifFczKGh? MmOwSG1UVw>? MonVTWM2OD1zMDFOwG0> NWPNRlF[OjN6NESwN|g>
CAL-62 M{TMSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYKxNEDPxE1? NV3sU2J5PzJiaB?= NUTLdJlITE2VTx?= Ml;oTWM2OD1zMDFOwG0> NHizU5ozOzh2NECzPC=>
Calu-3 NGG3XFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXSxNEDPxE1? NEDFU4E4OiCq MXzEUXNQ NGrhOmVKSzVyPUGwJO69VQ>? NHnnTY4zOzh2NECzPC=>
CaOV3 M3G2TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXWxNEDPxE1? NFHidpU4OiCq MVnEUXNQ MVrJR|UxRTFyIN88US=> MmK4NlM5PDRyM{i=
CGTHW1 MorWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPBNVAh|ryP NUK3eW9VPzJiaB?= MUjEUXNQ NEj0XHdKSzVyPUGwJO69VQ>? MnvrNlM5PDRyM{i=
CHL-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmmyNVAh|ryP MkO5O|IhcA>? MXTEUXNQ MkXCTWM2OD1zMDFOwG0> MVeyN|g1PDB|OB?=
Colo320DM MnrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13OS|ExKM7:TR?= MX[3NkBp MXnEUXNQ MYLJR|UxRTFyIN88US=> MYGyN|g1PDB|OB?=
Colo704 NH;ofYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXkRXh[OTBizszN Mn7EO|IhcA>? NWTOSm5xTE2VTx?= NYLKTGFPUUN3ME2xNEDPxE1? M1uwWFI{QDR2MEO4
COR-L23 M4fmUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4KzWlExKM7:TR?= MYS3NkBp MmLDSG1UVw>? NVjBTlV3UUN3ME2xNEDPxE1? MUiyN|g1PDB|OB?=
CRO-AP2 M{nuZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVm3dnpTOTBizszN MkHCO|IhcA>? NYHLPWRWTE2VTx?= MVvJR|UxRTFyIN88US=> MmX5NlM5PDRyM{i=
Daudi NUH1b|JOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2r6VFExKM7:TR?= MlrsO|IhcA>? MnOzSG1UVw>? M1jHfmlEPTB;MUCg{txO NVrJT45TOjN6NESwN|g>
DOTC 24510 NUHUTXFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfVNVAh|ryP MWm3NkBp MofTSG1UVw>? M3O2SmlEPTB;MUCg{txO MnTpNlM5PDRyM{i=
DU-145 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzmNVAh|ryP M3XlfFczKGh? MlHXSG1UVw>? MWjJR|UxRTFyIN88US=> NIPzeoIzOzh2NECzPC=>
EB-3 NUnxWZBWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXj5fIdLOTBizszN MXq3NkBp MYLEUXNQ M2eye2lEPTB;MUCg{txO NFjZV5MzOzh2NECzPC=>
EFM-19 NEPtPXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXSxXWoxOTBizszN NWXRU3dJPzJiaB?= MkL2SG1UVw>? MnXVTWM2OD1zMDFOwG0> MmDWNlM5PDRyM{i=
EKVX M1PBPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7yNVAh|ryP NX\qVVc{PzJiaB?= NXz3NWZJTE2VTx?= NFTzTIVKSzVyPUGwJO69VQ>? MUKyN|g1PDB|OB?=
FaDu NFTNNY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\mclYyOCEQvF2= NF\nXYc4OiCq MkLESG1UVw>? NUe3PZlIUUN3ME2xNEDPxE1? NX;2cZVVOjN6NESwN|g>
G401 NXvme3F7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mor4NVAh|ryP MXu3NkBp MUTEUXNQ MkfWTWM2OD1zMDFOwG0> MVuyN|g1PDB|OB?=
HCC-70 MoCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPtNVAh|ryP NVLjVJVpPzJiaB?= M{j6[GROW09? MXTJR|UxRTFyIN88US=> NY\RPHZLOjN6NESwN|g>
HCC-1954 NGDl[2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVKxNEDPxE1? M{TlSFczKGh? NWTtOZN4TE2VTx?= MmfKTWM2OD1zMDFOwG0> M1;hflI{QDR2MEO4
Hela NFizb|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDQNVAh|ryP M{D6SVczKGh? MYrEUXNQ MmLzTWM2OD1zMDFOwG0> M2rOWVI{QDR2MEO4
Hep3B MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHHNVAh|ryP M3;i[FczKGh? NFSzcXBFVVOR NYXpe5Q6UUN3ME2xNEDPxE1? MV:yN|g1PDB|OB?=
HMCB NX;1[GNmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3j1XVExKM7:TR?= MXG3NkBp M2TwOmROW09? MWrJR|UxRTFyIN88US=> M2PqdFI{QDR2MEO4
HN5 NUC3bId1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXmxNEDPxE1? MWC3NkBp NWnUXZQ4TE2VTx?= MYHJR|UxRTFyIN88US=> MmLvNlM5PDRyM{i=
HOS NFHvR3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoKxNVAh|ryP MYW3NkBp Ml3YSG1UVw>? MV\JR|UxRTFyIN88US=> M321dFI{QDR2MEO4
HPAF-II NGj2ellIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGj6VoIyOCEQvF2= M1;LfFczKGh? Ml\MSG1UVw>? M360XGlEPTB;MUCg{txO NF;kVG8zOzh2NECzPC=>
Hs746.T NFHVcWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlP1NVAh|ryP Mn3aO|IhcA>? MoXhSG1UVw>? NX[zRVF{UUN3ME2xNEDPxE1? NHyzUnIzOzh2NECzPC=>
HT M3HENWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPTNVAh|ryP MYq3NkBp MoPJSG1UVw>? NEXyUpdKSzVyPUGwJO69VQ>? NVvFUJFJOjN6NESwN|g>
HT-3 M33tVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vaUVExKM7:TR?= MYC3NkBp NXHOZWc2TE2VTx?= MlXRTWM2OD1zMDFOwG0> MlzXNlM5PDRyM{i=
HuNS-1 MkTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWi4bWx5OTBizszN Mn\MO|IhcA>? NITLS2FFVVOR NITzZ4NKSzVyPUGwJO69VQ>? MmHzNlM5PDRyM{i=
IGROV1 NIDOb4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zQZ|ExKM7:TR?= MknOO|IhcA>? NIfB[m1FVVOR NVLpcoFoUUN3ME2xNEDPxE1? M{fYelI{QDR2MEO4
J82 Mn30S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4n1ZlExKM7:TR?= M{nmTVczKGh? NIDqV5NFVVOR NFLwc41KSzVyPUGwJO69VQ>? MnTtNlM5PDRyM{i=
JM1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYSxNEDPxE1? M4\0W|czKGh? MY\EUXNQ M{nHXGlEPTB;MUCg{txO NYC5W5Q6OjN6NESwN|g>
Kato III NWTZXnNIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXyxNEDPxE1? NUfxfXBYPzJiaB?= NEnqSIpFVVOR NWWz[Wx{UUN3ME2xNEDPxE1? M{HiZVI{QDR2MEO4
KHOS-240S NUjlb4hHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHLVZhbOTBizszN M1fVZ|czKGh? MV7EUXNQ M2rzb2lEPTB;MUCg{txO NWfQV4JVOjN6NESwN|g>
KM-12 MlX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVmxNEDPxE1? MofXO|IhcA>? NWDVOXRoTE2VTx?= MXnJR|UxRTFyIN88US=> NFSwZY4zOzh2NECzPC=>
KPL-1 NVnh[WtsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrmfJZxOTBizszN Mk\oO|IhcA>? NVzFSGQ3TE2VTx?= NY\MSYFiUUN3ME2xNEDPxE1? MlS1NlM5PDRyM{i=
KYSE-30 MoHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rKe|ExKM7:TR?= NHP4Wmo4OiCq MnjRSG1UVw>? NUfQRWtLUUN3ME2xNEDPxE1? NYTtcVhPOjN6NESwN|g>
LNCaP M4e1PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7jR3RqOTBizszN M2iyOFczKGh? MYjEUXNQ M4TCWmlEPTB;MUCg{txO NU\nOFk1OjN6NESwN|g>
MCF-7 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfQNVAh|ryP NHzzXlM4OiCq Mn[ySG1UVw>? Moj0TWM2OD1zMDFOwG0> NGr6[WEzOzh2NECzPC=>
MC-IXC NGPkcVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY[xNEDPxE1? M4HPd|czKGh? NU[zfIo{TE2VTx?= Mke5TWM2OD1zMDFOwG0> MV:yN|g1PDB|OB?=
MDA-MB-175 VII MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzGNVAh|ryP NWK0d|dIPzJiaB?= NUS2TokxTE2VTx?= MXPJR|UxRTFyIN88US=> Mn;zNlM5PDRyM{i=
MDA-MB-468 NYXj[|V[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nlXVExKM7:TR?= MojPO|IhcA>? MkjhSG1UVw>? NHjXfmdKSzVyPUGwJO69VQ>? MnfKNlM5PDRyM{i=
MiaPaCa M3HLWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGf1No4yOCEQvF2= NYn4OphQPzJiaB?= NVLSeXRETE2VTx?= NHfEfGFKSzVyPUGwJO69VQ>? M1jUfFI{QDR2MEO4
Molt-4 NUG5cmFjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFX2TpoyOCEQvF2= MofsO|IhcA>? M1nYeWROW09? NHTWXFZKSzVyPUGwJO69VQ>? NGWzOI4zOzh2NECzPC=>
NCI-ADR/RES NHHl[W5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfzNVAh|ryP MkT0O|IhcA>? NFr3Z5lFVVOR M1;sUmlEPTB;MUCg{txO M33FU|I{QDR2MEO4
NCI-H69 NVPrNVhwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nQXlExKM7:TR?= MnzaO|IhcA>? M{XQeWROW09? NEXWdFRKSzVyPUGwJO69VQ>? NEfENpYzOzh2NECzPC=>
NCI-H82 MkjtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGC2emoyOCEQvF2= NF\OXGI4OiCq MV\EUXNQ NUXVXIRKUUN3ME2xNEDPxE1? MkjuNlM5PDRyM{i=
NCI-N87 Mo\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVOxNEDPxE1? MWm3NkBp MYHEUXNQ NVGzNlZiUUN3ME2xNEDPxE1? NYG3[VdsOjN6NESwN|g>
NCI-H146 NV60N4tQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPaeocyOCEQvF2= NYS5cHRRPzJiaB?= MVfEUXNQ NXX0bHFtUUN3ME2xNEDPxE1? MonnNlM5PDRyM{i=
NCI-H157 M2XSV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYmxNEDPxE1? MonqO|IhcA>? M3rMSmROW09? MWfJR|UxRTFyIN88US=> M3zlR|I{QDR2MEO4
NCI-H187 NVjyfpJuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXEOYZoOTBizszN M2PjeVczKGh? MlXvSG1UVw>? NXfBcIhVUUN3ME2xNEDPxE1? NE\tNVMzOzh2NECzPC=>
NCI-H209 MkDrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYGxNEDPxE1? M13COFczKGh? NWPyZ|U3TE2VTx?= MmjETWM2OD1zMDFOwG0> NYHSOYFyOjN6NESwN|g>
NCI-H226 M2DTd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYri[2ptOTBizszN M3n4d|czKGh? MUTEUXNQ NYXWRYZ4UUN3ME2xNEDPxE1? NIHj[3YzOzh2NECzPC=>
NCI-H292 M4TGVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;NV5NtOTBizszN MV63NkBp MmrISG1UVw>? MVzJR|UxRTFyIN88US=> M2ToSFI{QDR2MEO4
NCI-H322 Mn31S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2P2flExKM7:TR?= MofyO|IhcA>? MV7EUXNQ Ml7OTWM2OD1zMDFOwG0> MYqyN|g1PDB|OB?=
NCI-H358 NGDnRXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PPWVExKM7:TR?= MV23NkBp MVXEUXNQ M1j3cmlEPTB;MUCg{txO MWKyN|g1PDB|OB?=
NCI-H520 NYjaSJh1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvURmkyOCEQvF2= NG\MTnA4OiCq MWXEUXNQ MYTJR|UxRTFyIN88US=> M3\ZZ|I{QDR2MEO4
NCI-H526 M2TRPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3Tae|ExKM7:TR?= NVnPdJRMPzJiaB?= NWfjOYRYTE2VTx?= MWjJR|UxRTFyIN88US=> NYiyW5BNOjN6NESwN|g>
NCI-H630 NH7h[m5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTTTGV[OTBizszN MmTTO|IhcA>? NWGxc5R5TE2VTx?= NH3pRmdKSzVyPUGwJO69VQ>? MVKyN|g1PDB|OB?=
NCI-H661 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVGxNEDPxE1? M1uw[|czKGh? MojESG1UVw>? MV7JR|UxRTFyIN88US=> MWWyN|g1PDB|OB?=
NCI-H716 NYXtNXZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVmxNEDPxE1? MmD5O|IhcA>? M{LBTWROW09? NWXJWolpUUN3ME2xNEDPxE1? M4ftSFI{QDR2MEO4
NCI-H1563 NH25XIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHX[XhCOTBizszN NEXEeWg4OiCq NXnXOJFZTE2VTx?= MmmwTWM2OD1zMDFOwG0> MmDZNlM5PDRyM{i=
NCI-H1792 MmTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjZN4IyOCEQvF2= M2HkOFczKGh? M2O1d2ROW09? NVfuTJFKUUN3ME2xNEDPxE1? MWCyN|g1PDB|OB?=
NCI-H2030 M3XO[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnl[mVmOTBizszN M4XtSlczKGh? NGS4R41FVVOR NFq2ZVRKSzVyPUGwJO69VQ>? MXeyN|g1PDB|OB?=
NCI-H2052 MnvNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX2xNEDPxE1? NVrkUnJVPzJiaB?= NFvCWYNFVVOR M3zOVWlEPTB;MUCg{txO M2rkUVI{QDR2MEO4
NCI-H2122 NEfYZYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnCcppWOTBizszN Mom2O|IhcA>? M2T6fWROW09? NHvwbJVKSzVyPUGwJO69VQ>? NXvheW5DOjN6NESwN|g>
NCI-H2228 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LMRlExKM7:TR?= M3v5UFczKGh? MWPEUXNQ NFLjdIRKSzVyPUGwJO69VQ>? MoLGNlM5PDRyM{i=
OE-19 MmXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjzTmZUOTBizszN NFG1TpM4OiCq NGn6cmVFVVOR MXrJR|UxRTFyIN88US=> NGrDcIQzOzh2NECzPC=>
OE-21 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF[xU48yOCEQvF2= M4\zelczKGh? MV7EUXNQ MlzTTWM2OD1zMDFOwG0> NV3QW5N[OjN6NESwN|g>
OE-33 M2C4[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LWelExKM7:TR?= M4PZO|czKGh? Mnj4SG1UVw>? NXK0XGtsUUN3ME2xNEDPxE1? NXzrSpNxOjN6NESwN|g>
OVCAR-3 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInTUoQyOCEQvF2= MXi3NkBp NUnONmhHTE2VTx?= NWLpdoV2UUN3ME2xNEDPxE1? NFXEdIYzOzh2NECzPC=>
OVCAR-4 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVSxNEDPxE1? M16wflczKGh? NFe3NoZFVVOR MoD6TWM2OD1zMDFOwG0> NYPRUIpUOjN6NESwN|g>
OVCAR-5 MnjuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3e5NVExKM7:TR?= M{HOXlczKGh? MVLEUXNQ NIfzemdKSzVyPUGwJO69VQ>? M2TUZlI{QDR2MEO4
P3HR-1 M2\Xc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXOxNEDPxE1? M3HJOVczKGh? NYDaNodRTE2VTx?= MUnJR|UxRTFyIN88US=> NELtdWYzOzh2NECzPC=>
PC-3 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXENVAh|ryP Mlr3O|IhcA>? Mn7NSG1UVw>? NWXyTFdjUUN3ME2xNEDPxE1? MnXVNlM5PDRyM{i=
Raji M4fkemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHvNVAh|ryP NVzaOYU2PzJiaB?= NH3rVWxFVVOR MmDtTWM2OD1zMDFOwG0> MonmNlM5PDRyM{i=
RD M1HlfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37tWFExKM7:TR?= MUO3NkBp NX;HNpFNTE2VTx?= NHH1SmxKSzVyPUGwJO69VQ>? NVftTJZjOjN6NESwN|g>
RD-ES MmfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzkTI1nOTBizszN MX63NkBp NEjxXoFFVVOR NGDXSI1KSzVyPUGwJO69VQ>? NFTrcFczOzh2NECzPC=>
RL MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknkNVAh|ryP MYO3NkBp NV3X[pZlTE2VTx?= MmXJTWM2OD1zMDFOwG0> NGT6WnAzOzh2NECzPC=>
SaOS2 MmCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\2UlExKM7:TR?= NFf0[pk4OiCq MknuSG1UVw>? M3q4VGlEPTB;MUCg{txO MmTLNlM5PDRyM{i=
SCC-9 NHLxcZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLqVVcyOCEQvF2= MU[3NkBp NW\3WJM1TE2VTx?= NITKW3pKSzVyPUGwJO69VQ>? NVHXeHI6OjN6NESwN|g>
SCC-12 MoHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVf3WGU5OTBizszN MWO3NkBp NGHQT4dFVVOR M4PNc2lEPTB;MUCg{txO MnjINlM5PDRyM{i=
SCC-13 MkPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TSTlExKM7:TR?= NEOyfIs4OiCq Mm[5SG1UVw>? M4HoOmlEPTB;MUCg{txO MYOyN|g1PDB|OB?=
SCC-15 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\jUlEyOCEQvF2= NFLPUlE4OiCq NG\VN|lFVVOR MoXLTWM2OD1zMDFOwG0> NHrpWmYzOzh2NECzPC=>
SCC-25 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\XNVAh|ryP MoDMO|IhcA>? NH3GPVVFVVOR MXTJR|UxRTFyIN88US=> M1fK[FI{QDR2MEO4
SCLC-3 M1XJbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1Pj[VExKM7:TR?= NH;DcGQ4OiCq MYXEUXNQ NF\RTIhKSzVyPUGwJO69VQ>? MmrlNlM5PDRyM{i=
SF-268 M1z5SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFryfmMyOCEQvF2= M2rUV|czKGh? M3G3PWROW09? MnrRTWM2OD1zMDFOwG0> MliyNlM5PDRyM{i=
SF-295 NIXHTmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\jU|ExKM7:TR?= NVK5XVdxPzJiaB?= NF\XfFFFVVOR MmD2TWM2OD1zMDFOwG0> NV[xPHlROjN6NESwN|g>
SJRH30 MojUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYSxNEDPxE1? M1G3eFczKGh? MmKySG1UVw>? NVv0PGtrUUN3ME2xNEDPxE1? M3X1c|I{QDR2MEO4
SK-BR-3 NEPUdIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvpNpAyOCEQvF2= MXm3NkBp M1npOmROW09? MnzRTWM2OD1zMDFOwG0> M3SyZlI{QDR2MEO4
SK-LMS-1 NXTmXml[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M331e|ExKM7:TR?= M33pUlczKGh? MYDEUXNQ M2rJOmlEPTB;MUCg{txO M4XGRVI{QDR2MEO4
SK-N-DZ MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHrZZcyOCEQvF2= NYXGdJhUPzJiaB?= MXfEUXNQ M3vpTGlEPTB;MUCg{txO NWPWVGxZOjN6NESwN|g>
SK-N-F1 M1[5emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLpNVAh|ryP MX[3NkBp NIe0PVRFVVOR NUPIWGFnUUN3ME2xNEDPxE1? MVeyN|g1PDB|OB?=
SKOV-3 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjuWFdyOTBizszN M3fkTVczKGh? M2O0dmROW09? MUTJR|UxRTFyIN88US=> MXuyN|g1PDB|OB?=
SK-UT-1 NFHBclhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUn3UYxkOTBizszN MXu3NkBp Ml\ESG1UVw>? M1zibGlEPTB;MUCg{txO M{HyclI{QDR2MEO4
SN12C MmrKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWixNEDPxE1? MlrlO|IhcA>? M1HkdmROW09? NYHoTXpEUUN3ME2xNEDPxE1? M3fieVI{QDR2MEO4
SNB-19 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLMNVAh|ryP Ml3EO|IhcA>? M1q0emROW09? MmToTWM2OD1zMDFOwG0> MUSyN|g1PDB|OB?=
SNU-5 NV7TWINST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUexNEDPxE1? MVS3NkBp NWTPOFF6TE2VTx?= MUjJR|UxRTFyIN88US=> NH\JXogzOzh2NECzPC=>
SNU-16 M{OyTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGL0eYsyOCEQvF2= NHPQR5M4OiCq MWjEUXNQ MoLDTWM2OD1zMDFOwG0> M1rCWVI{QDR2MEO4
SNU-398 NH3lO5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXmT5dOOTBizszN MoW4O|IhcA>? NYTPNWxsTE2VTx?= NHvDRppKSzVyPUGwJO69VQ>? M3rLWVI{QDR2MEO4
SNU-449 Ml\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;i[IUyOCEQvF2= MYS3NkBp NF3HbGlFVVOR M2OwdWlEPTB;MUCg{txO NXnLfml4OjN6NESwN|g>
SR NVG0NIl4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3mXIYyOCEQvF2= MorhO|IhcA>? NXjq[oNtTE2VTx?= MVLJR|UxRTFyIN88US=> MkDENlM5PDRyM{i=
ST486 MnzIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXOxNEDPxE1? MVG3NkBp MV\EUXNQ MXrJR|UxRTFyIN88US=> M1G3bFI{QDR2MEO4
SW579 NFv4SnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfsbXdLOTBizszN MnvIO|IhcA>? NYHBc41wTE2VTx?= M4PnNWlEPTB;MUCg{txO MYmyN|g1PDB|OB?=
SW684 NUS0ZlRFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfCWI8yOCEQvF2= NFnFXYQ4OiCq NULkUmhbTE2VTx?= MorXTWM2OD1zMDFOwG0> MX[yN|g1PDB|OB?=
SW-780 MnXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWCxNEDPxE1? NXz3OG1ZPzJiaB?= MV;EUXNQ NEjQRWlKSzVyPUGwJO69VQ>? NWT4OlR2OjN6NESwN|g>
SW900 NIrpVohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\wNVAh|ryP MVu3NkBp MkPySG1UVw>? MWrJR|UxRTFyIN88US=> MkfNNlM5PDRyM{i=
SW1088 NHnEPGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlX3NVAh|ryP M1:yVFczKGh? NUizb3lVTE2VTx?= MWnJR|UxRTFyIN88US=> MVmyN|g1PDB|OB?=
SW1463 NXTPe3NGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\MNVAh|ryP NIj2WYY4OiCq M4jjTGROW09? NGrQRldKSzVyPUGwJO69VQ>? NYG1PY1zOjN6NESwN|g>
SW1990 M4qw[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfCNYEyOCEQvF2= NGXBSmg4OiCq M1zJS2ROW09? NX3wd5NrUUN3ME2xNEDPxE1? NHjWbo8zOzh2NECzPC=>
T47D MmXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonnNVAh|ryP MmnMO|IhcA>? MYHEUXNQ MV7JR|UxRTFyIN88US=> NWj3fmtqOjN6NESwN|g>
TE381.T M1u1XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HifFExKM7:TR?= M3;iU|czKGh? NF3vSolFVVOR NFzPXGRKSzVyPUGwJO69VQ>? NVu0O5RLOjN6NESwN|g>
TK-10 NUT2W2pmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnncY5yOTBizszN MnHZO|IhcA>? MX\EUXNQ NIjGVYFKSzVyPUGwJO69VQ>? NV;kemMzOjN6NESwN|g>
U2OS MlfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIP0WXUyOCEQvF2= NWfSTnJZPzJiaB?= NHvRVHJFVVOR M{DyemlEPTB;MUCg{txO MVWyN|g1PDB|OB?=
U251 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV2xNEDPxE1? M1fXO|czKGh? MmP1SG1UVw>? M170VmlEPTB;MUCg{txO MnLGNlM5PDRyM{i=
UACC-812 MoLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXuxNEDPxE1? NWnh[pFWPzJiaB?= M2HEfmROW09? MkexTWM2OD1zMDFOwG0> NUHGNGt1OjN6NESwN|g>
YAPC MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\rNVAh|ryP MUi3NkBp NWrvdI9KTE2VTx?= NU\1PJNSUUN3ME2xNEDPxE1? MVmyN|g1PDB|OB?=
ZR-75-1 M4\1Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXThdHdUOTBizszN M{fwW|czKGh? MUnEUXNQ MnjBTWM2OD1zMDFOwG0> NEfpT4gzOzh2NECzPC=>
A375 NV3tO|JvTnWwY4Tpc44h[XO|YYm= M2\0PFEvOiEQvF2= NH\DflA1KGh? MnjnSG1UVw>? MYfJcohq[mm2aX;uJI9nKHCqb4PwbI9zgWyjdHnvckBw\iCPRVusJGVTUyxiYX7kJHM3WA>? M4S5N|IzOzh7NEex
YUSIT1 MnGwSpVv[3Srb36gZZN{[Xl? M1SxcmROW09? M{LqV5Jm\HWlZXSgd4Vve2m2aY\peJkhf2m2aDDJR|UxKD5iMD61JO69VQ>? NF:zWmozOjN6OUS3NS=>
MeWo MYPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MorOSG1UVw>? MWnJR|UxKD1iOUi3JI5O NIXzNFEzPjBzOEWyOC=>
WiDr MmSwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEnIS5JFVVOR MUnJR|UxKD1iN{[gcm0> M2XZ[lI3ODF6NUK0
Colo-205 MWDGeY5kfGmxbjDhd5NigQ>? M1jTdFEh|ryP M{nF[VQh\A>? NGTucpZFVVOR M{HBOWlv\HWlZXSgZUBpcWeqbImgZ49ueGG{YXLs[UBkd22yYXP0bY9vKHCqZX7veJlx\Q>? NIe2fmIzPTN6MUG1Ni=>
RBW-1 NEH2XWxHfW6ldHnvckBie3OjeR?= MU[xJO69VQ>? MV;EUXNQ MnLKUo8hemWmdXP0bY9vKG:oIF3lb{AyNzJicHjvd5Bpd3K7bHH0bY9v NI\6TVIzPDh6NU[5NC=>
RBO-1 NEjZVJpHfW6ldHnvckBie3OjeR?= M33XcFEh|ryP M{PNcWROW09? NVvQc2pxUW6qaXLpeIlwdiCxZjDN[YshOS9{IIDoc5NxcG:{eXzheIlwdg>? Ml3rNlQ5QDV4OUC=
RBO-2 M3\5NWZ2dmO2aX;uJIF{e2G7 Mn7FNUDPxE1? NFHnXHRFVVOR MWfJcohq[mm2aX;uJI9nKCCPZXugNU8zKHCqb4PwbI9zgWyjdHnvci=> NXn6dY94OjR6OEW2PVA>
RBOW MVXGeY5kfGmxbjDhd5NigQ>? NUXIb|Z6OSEQvF2= MoCwSG1UVw>? NUH5cI51UW6qaXLpeIlwdiCxZjCgUYVsKDFxMjDwbI9{eGixconsZZRqd25? MUCyOFg5PTZ7MB?=
M257 M1:xcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrqNVAxKG6P NVj2RVB6PzJiaB?= MYPEc4V{KG6xdDDpcohq[mm2IIDyc4xq\mW{YYTpc44hd2ZiTUK1O{Bk\WyuIHjhdoJwfXKrbnege4lt\CC2eYDlJGJTSUZ? M3XKRlI{OzF5NES2
LCP MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfwSXYyODBibl2= MVG3NkBp MofVTY5pcWKrdHnvckBw\iCycn;sbYZmemG2aX;uJI9nKEyFUDDj[YxtKGijcnLveZJqdmdiQmLBSkBXPjByUjDteZRidnSjdHnvci=> MWmyN|MyPzR2Nh?=
WM266 MlTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn6wNVAxKG6P NVjKXpJtPzJiaB?= M3HpZWlvcGmkaYTpc44hd2ZicILvcIln\XKjdHnvckBw\iCZTUK2OkBk\WyuIHjhdoJwfXKrbnegRnJCTiCYNkCxSEBufXSjboTheIlwdg>? MkTGNlM{OTd2NE[=
M257 NXLPVZNnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3r4OFExOCCwTR?= MlnZO|IhcA>? NYnC[I9GTG:nczDuc5QhcW6qaXLpeEBGWktzLUKgdIhwe3Cqb4L5cIF1cW:wIHnuJG0zPTdiY3XscEBp[XKkb4XybY5oKHerbHSgeJlx\SCEUlHG MmHNNlM{OTd2NE[=
LCP M4K1VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXqb4IzOTByIH7N NYDkV2p[PzJiaB?= M4rEdWlvcGmkaYSgSXJMOS1{IIDoc5NxcG:{eXzheIlwdiCrbjDMR3Ah[2WubDDoZZJjd3W{aX7nJGJTSUZiVk[wNHIhdXW2YX70ZZRqd25? M3XUdFI{OzF5NES2
WM266 NE\s[JZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfzVFBtOTByIH7N MWq3NkBp MVvJcohq[mm2IFXST|EuOiCyaH;zdIhwenmuYYTpc44hcW5iV12yOlYh[2WubDDoZZJjd3W{aX7nJGJTSUZiVk[wNGQhdXW2YX70ZZRqd25? Mkn3NlM{OTd2NE[=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pMEK / pERK / ERK; 

PubMed: 31158244     


Cell lines as shown were treated with dabrafenib, over a dose range, for 1 hour. UT = untransfected.  Expression and/or phosphorylation of the indicated proteins were assessed by immunoblot.

p-S6 / p-AKT308 / p-AKT473; 

PubMed: 24735930     


Western blot analysis of phosphorylated proteins in MAPK and the PI3K-AKT pathway after 24 hours exposure to increasing concentrations of dabrafenib.

β-catenin; 

PubMed: 29167314     


HT-29 cells were treated with BRAF inhibitors Dabrafenib (2 μM), GDC-0879 (4 μM) or Vemurafenib (2 μM) for indicated times. The whole cell lysates were used for western blot with indicated antibodies.

31158244 24735930 29167314
Growth inhibition assay
IC50; 

PubMed: 24735930     


A panel of 23 BRAF(V600) mutant human melanoma cell lines was treated with serial dilutions (1-10,000 nM) of dabrafenib (A) for 72-120 hours to assess cell viability. The bars represent the average IC50 value of two or more independent experiments in duplicates and the error bars represent the SEM. 

24735930
体内研究 Dabrafenib(口服)抑制B-RafV600E突变的黑色素瘤(A375P)的生长,在免疫受损小鼠中皮下注射结肠癌(Colo205),Dabrafenib(口服)同样能抑制肿瘤生长。 [1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

溶解度 (25°C)

体外 DMSO 30 mg/mL (57.74 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
2% DMSO+45% PEG 300+2% Tween 80+ddH2O
5 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 519.56
化学式

C23H20F3N5O2S2

CAS号 1195765-45-7
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04059224 Recruiting Drug: Trametinib|Drug: Dabrafenib Stage IV Melanoma|Stage III Melanoma Universitair Ziekenhuis Brussel January 28 2019 Phase 2
NCT03668431 Recruiting Drug: Dabrafenib|Drug: Trametinib|Drug: PDR001 Metastatic Colorectal Cancer Massachusetts General Hospital|Novartis|Stand Up To Cancer October 15 2018 Phase 2
NCT03553329 Completed Drug: dabrafenib Unresecable Stage IIIc or IV Melanoma Poitiers University Hospital June 2 2018 --
NCT03593993 Recruiting Procedure: Surgical Cohort Glioma|BRAF V600E|Pleomorphic Xantho-Astrocytoma|Glioblastoma Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins|Musella Foundation May 19 2018 --
NCT03340506 Recruiting Drug: dabrafenib|Drug: trametinib Melanoma|Non Small Cell Lung Cancer|Solid Tumor|Rare Cancers|High Grade Glioma Novartis Pharmaceuticals|Novartis December 28 2017 Phase 4

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

Raf Signaling Pathway Map

Raf Inhibitors with Unique Features

相关Raf产品

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID