Dabrafenib (GSK2118436)

目录号:S2807

Dabrafenib (GSK2118436) Chemical Structure

Molecular Weight(MW): 519.56

Dabrafenib (GSK2118436)是一种突变型BRAFV600特异性抑制剂,无细胞试验中IC50为0.7 nM,作用于B-Raf(wt)和c-Raf效果分别低7和9倍。

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RMB 1481.39 现货
RMB 733.64 现货
RMB 1056.75 现货
RMB 1394.46 现货
RMB 2235.84 现货
RMB 3261.37 现货
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客户使用Selleck该产品发表文献21篇:

客户使用该产品的9个实验数据:

  • BRAFi/MEKi-resistant A375DR and the parental A375 cells were treated with 2 μM vorinostat and/or the combination of 0.125 μM dabrafenib and 5 nM trametinib. Protein lysates were harvested after 72 hr. Western blot analysis was carried out for p-MEK and p-P90RSK as indicators of activation of MAPK pathway, ac-H3 as indicator for levels of acetylated histone H3 and a-tubulin as a loading control.

    Cell, 2018, 173(6):1413-1425. Dabrafenib (GSK2118436) purchased from Selleck.

    A375P cells were treated with vehicle, the BRAF inhibitor GSK2118436, the MEK inhibitor GSK1120212, 10 uM HCQ, or the indicated combinations. Shown are 48-hour immunoblots directed against the indicated proteins.

    J Clin Invest 2014 24(3), 1406-17. Dabrafenib (GSK2118436) purchased from Selleck.

  • Levels of pERK and tERK in the CLL cells derived from PBMC were measured by Western blot. We used vemurafenib, dabrafenib, and trametinib (0.07 uM) as indicated. One of 3 independent experiments with similar results is shown. CLL cells exposed to dabrafenib or vemurafenib had an elevated pERK/tERK ratio as compared with vehicle (P < 0.01).

    J Clin Invest 2014 124(11), 5074-84. Dabrafenib (GSK2118436) purchased from Selleck.

    Immunoblotting of whole-cell lysates of WM1366 exposed to the indicated drugs for 48 hours using specific antibodies for phospho-acetyl CoA carboxylase (p-ACC), total acetyl CoA carboxylase (t-ACC), phospho-ERK1/2 (p-ERK1/2), and total ERK1/2 (t-ERK1/2). Immunoblots were quantified using ImageJ. The ratio of phosphorylated to total protein normalized to control is shown above the respective blots.

    Clin Cancer Res, 2018, 24(5):1090-1102. Dabrafenib (GSK2118436) purchased from Selleck.

  • Braf−/− ER(TM)-HRAS(G12V) MEFs were transduced with retroviral constructs encoding the indicated BRAF proteins and treated with 4-HT to release oncogenic RAS, or ethanol as a control. Following incubation with 1 μM vemurafenib, 1 μM dabrafenib or DMSO as a control for 4 h, cells were subjected to western blot analysis with the indicated antibodies.

    Leukemia, 2016, 30(4):937-46. Dabrafenib (GSK2118436) purchased from Selleck.

    Western blots for untreated, early, and late tumors.

    Cancer research, 2018, 78(2):542-557. Dabrafenib (GSK2118436) purchased from Selleck.

  • Dabrafenib alleviates acetaminophen-induced hepatotoxicity in mice. Mice were treated with 300 mg/kg acetaminophen (i.p.), with or without pretreatment with 300 mg/kg or 100 mg/kg dabrafenib (p.o.).TUNEL staining for nuclear DNA fragmentation in mouse liver cells.

    Cell Death Dis 2014 5, e1278. Dabrafenib (GSK2118436) purchased from Selleck.

    The effects of inhibitors of mutant BRAFV600 inhibitor dabrafenib on cancer cell growth were evaluated by the MTT assay. Cell growth inhibition of FRO and SW1736 cell lines induced by dabrafenib.

    Transl Res 2014 10.1016/j.trsl.2014.06.005. Dabrafenib (GSK2118436) purchased from Selleck.

  • Western blot analysis of p-Erk and total ERK in A375 melanoma cell line after treatment with different doses of Dabrafenib for 48 hours (A). p-ERK signal was normalized with total ERK signal (B), SD and means of the normalized p-ERK values were reported.

    PLoS One, 2016, 11(3):e0152104. Dabrafenib (GSK2118436) purchased from Selleck.

产品安全说明书

Raf抑制剂选择性比较

生物活性

产品描述 Dabrafenib (GSK2118436)是一种突变型BRAFV600特异性抑制剂,无细胞试验中IC50为0.7 nM,作用于B-Raf(wt)和c-Raf效果分别低7和9倍。
靶点
B-Raf (V600E) [3]
(Cell-free assay)
B-Raf [3]
(Cell-free assay)
C-Raf [3]
(Cell-free assay)
0.7 nM 5.2 nM 6.3 nM
体外研究

Dabrafenib对Raf激酶具有选择性,对B-Raf的活性比其它测试过的91%的激酶高400倍。 Dabrafenib抑制B-RafV600E激酶,导致ERK磷酸化降低和抑制细胞的增值,在特异性编码突变的B-RafV600E的癌细胞中细胞停滞在G1期。

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MVfLbY5ie2ViQYPzZZk> NUjJV5Z6UW6qaXLpeIlwdiCxZjDOMZRmem2rbnHsJGhqeyC2YXfn[YQhSi2UYX[gWlYxOEVibYX0ZY51KGW6cILld5Nm\CCrbjDiZYN2dG:4aYL1d{Bqdm[nY4Tl[EBqdnOnY4SgZ4VtdHNiY3:t[ZhxemW|c3nu[{BETEN|NzDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiCkaX;0bY56dGG2ZXStUWVMKHC{b4TlbY4heGixc4Doc5J6dGG2aX;uJIJ6KEGucHjhV4Nz\WWwIHHzd4F6KHerdHigTWM2OCCxZjCwMlAxODdizszN MYiyOFkxODZ5Mx?=
SK-MEL-28 NFnwZYpMcW6jc3WgRZN{[Xl? NGnySW4yKGh? M{\3dWlvcGmkaYTpc44hd2ZiQj3SZYYhXjZyMFWgcZV1[W62IHnuJIh2dWGwIGPLMW1GVC1{ODDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBGWkticHjvd5Bpd3K7bHH0bY9vKHerdHigTWM2OCCxZjCwMlAxPCEQvF2= NEn3eXkzPDlyME[3Ny=>
HepG2 NHfWU3hMcW6jc3WgRZN{[Xl? NIXHO3lKdmirYnn0bY9vKG:oIFKtVoFnKFZ4MEDFJI12fGGwdDDpckBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDFVmsheGixc4Doc5J6dGG2aX;uJJdqfGhiSVO1NEBw\iByLkCwOEDPxE1? MYSyOFkxODZ5Mx?=
COLO205 M{HzOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV73Zo1mUW6qaXLpeIlwdiCxZjDoeY1idiCFT1zPNlA2KGOnbHygdJJwdGmoZYLheIlwdiC5aYToJGlEPTBib3[gNE4xODdizszN NX3MbGFuOjR7MEC2O|M>
HepG2 MWTGeY5kfGmxbjDBd5NigQ>? MlLxOFUhdWmw MVfEUXNQ NWnvbHdNUW6qaXLpeIlwdiCxZjDBcIs2KGmwIGTHSk1j\XSjLYP0bY12dGG2ZXSgbJVu[W5iSHXwS|Ih[2WubIOgZZN{\XO|ZXSgZZMh\GWlcnXhd4UhcW5iU33h[FIheGixc4Doc5J6dGG2aX;uJJRz\WG2ZXSg[o9zKDR3IH3pcpMheHKrb4KgeI8hXEeILXLleIEhe3SrbYXsZZRqd25ibXXhd5Vz\WRiYX\0[ZIhPjBibXnud{BjgSCxZInzd4V6KGKub4Sgd4Nidm6ncjDhcoFtgXOrczD3bZRpKEmFNUCgc4YhOy55IN88US=> MXOyOFkxODZ5Mx?=
HFF NHm0WJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NESz[4syOCEQvF2= NGjsUZE4OiCq NUX3RopnTE2VTx?= NFvZNINKdmirYnn0bY9vKG:oIIDyc4xq\mW{YYTpc44hd2ZiaIXtZY4hUE[IIHPlcIx{KGijcnLvdolv\yC5aXzkJJR6eGViQj3SZYYhf2m2aDDJR|UxKG:oIEOg{txO MkexNlM5PDRyM{i=
SK-MEL-28 M3e0PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXOxNEDPxE1? MVe3NkBp NXnrbVVyTE2VTx?= NHu2XFVKdmirYnn0bY9vKG:oIFKtVoFnKFZ4MEDFJI12fGGwdD3kdol3\W5iU1utUWVNNTJ6IHPlcIwheHKxbHnm[ZJifGmxbjD3bZRpKEmFNUCgc4YhOC5yNEOg{txO MXmyN|g1PDB|OB?=
A375P-F11 NHT1TVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nBeFExKM7:TR?= NHq2Ros4OiCq MVnEUXNQ MkTVTY5pcWKrdHnvckBw\iCELWLh[kBXPjByRTDteZRidnRvZILpeoVvKEF|N{XQMWYyOSClZXzsJJBzd2yrZnXyZZRqd25id3n0bEBKSzVyIH;mJFAvODdzIN88US=> M2fHN|I{QDR2MEO4
MALME-3M M4L1cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXSxNEDPxE1? MYq3NkBp M4XaZmROW09? NGfI[lRKSzVyPUGgcm0> M2DMZVI{QDR2MEO4
UACC-62 NITzXpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXyxNEDPxE1? NV3PPYhYPzJiaB?= MoW0SG1UVw>? MULJR|UxRTFibl2= MVGyN|g1PDB|OB?=
C32TG NHvkXYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYCxNEDPxE1? NWTWd2JVPzJiaB?= MnjoSG1UVw>? NEnaSZBKSzVyPUGgcm0> MVmyN|g1PDB|OB?=
SK-MEL-1 M2Ljd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlntNVAh|ryP MlfFO|IhcA>? M3T5VWROW09? NW\tUXF2UUN3ME2yJI5O NXfPcFExOjN6NESwN|g>
M14 MlfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HjPVExKM7:TR?= NE[5SlI4OiCq M{HxfmROW09? MWjJR|UxRTJibl2= MYqyN|g1PDB|OB?=
SK-MEL-28 M1u0OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHySpUyOCEQvF2= MVe3NkBp Mm\0SG1UVw>? MVrJR|UxRTNibl2= MV2yN|g1PDB|OB?=
A375 NWTBPIxGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1L0S|ExKM7:TR?= NXSzO5RkPzJiaB?= M2XPcmROW09? NEj1O5RKSzVyPUSgcm0> M{WycVI{QDR2MEO4
DU-4475 M3vaUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{H4WFExKM7:TR?= MkG3O|IhcA>? NGnHRpZFVVOR NX\xTWc2UUN3ME21JI5O NH\QRZozOzh2NECzPC=>
UACC-257 Mof1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XvTVExKM7:TR?= NYeyRlg5PzJiaB?= M174UmROW09? MVvJR|UxRTZibl2= M2i0TlI{QDR2MEO4
Colo 205 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml62NVAh|ryP MYe3NkBp MVLEUXNQ NVzxSItZUUN3ME23JI5O MVOyN|g1PDB|OB?=
SK-MEL-3 NEX6NVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlG2NVAh|ryP MkTOO|IhcA>? MXzEUXNQ MonLTWM2OD15IH7N MWqyN|g1PDB|OB?=
SH-4 M{Hmfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHhRnUyOCEQvF2= Mn30O|IhcA>? NHOwZZlFVVOR M2S0[GlEPTB;ODDuUS=> MYCyN|g1PDB|OB?=
A101D MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\WNVAh|ryP M4Kyd|czKGh? NFHEfHBFVVOR MkfDTWM2OD17IH7N MWmyN|g1PDB|OB?=
ES-2 NFPrSndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYWxNEDPxE1? M13FU|czKGh? NG\FVodFVVOR NH3Ob2dKSzVyPUWzJI5O MWeyN|g1PDB|OB?=
HT-29 M3TFWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWOxNEDPxE1? NGfrNIo4OiCq MWXEUXNQ NEiySWFKSzVyPU[2JI5O NEDId2EzOzh2NECzPC=>
SW1417 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1X6[VExKM7:TR?= MYS3NkBp MnjGSG1UVw>? NVvXbFN3UUN3ME2xOVghdk1? MnLWNlM5PDRyM{i=
SW872 Ml;QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLuNVAh|ryP M1vTcFczKGh? MVnEUXNQ NFe2ZY5KSzVyPUO3O{BvVQ>? M3PIe|I{QDR2MEO4
RKO NWfvdo5JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\oNVAh|ryP NYTSUGl3PzJiaB?= M3\3S2ROW09? M2TrWGlEPTB;Mj61NlIh|ryP NX7rSIROOjN6NESwN|g>
A673 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3G1PVExKM7:TR?= NYLyXmp6PzJiaB?= Mn\ZSG1UVw>? NXnQdlN7UUN3ME2xNEDPxE1? NGW0VXQzOzh2NECzPC=>
GCT NFXIT5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHyzc5UyOCEQvF2= NUXQdY4xPzJiaB?= NFPaXZJFVVOR MWTJR|UxRTFyIN88US=> M4njVVI{QDR2MEO4
WM-115 M3LSOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV:xNEDPxE1? MVO3NkBp NXHFWFFRTE2VTx?= NF23NpFKSzVyPUWgcm0> MWCyN|g1PDB|OB?=
YUMAC MmDoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rR[|ExKM7:TR?= MnLZO|IhcA>? M1riT2ROW09? MonGTWM2OD13IH7N NIK1[lAzOzh2NECzPC=>
OV-90 M{nodWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3y5dVExKM7:TR?= M4\jTVczKGh? MYnEUXNQ MX\JR|UxRTJ7IH7N MmS1NlM5PDRyM{i=
NCI-H508 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4W1O|ExKM7:TR?= NVT5bZkyPzJiaB?= MYXEUXNQ NWTYZYJyUUN3ME2xNEDPxE1? M3LSXVI{QDR2MEO4
MDA-MB-231 M1zl[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zsRVExKM7:TR?= MYG3NkBp NIfKOlZFVVOR NUDReVhPUUN3ME2xNEDPxE1? Mkm2NlM5PDRyM{i=
SW756 NWTz[XFLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XkTVExKM7:TR?= M{T5ZVczKGh? M1H4ZWROW09? M2TuW2lEPTB;MUCg{txO M4G0OVI{QDR2MEO4
SW-837 NHrwW|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYOxNEDPxE1? NWDlPVNXPzJiaB?= MoCwSG1UVw>? NFXNTZFKSzVyPUGwJO69VQ>? NWjhN3hmOjN6NESwN|g>
UMUC-3 NUXsXXpoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzTNVAh|ryP Mo\yO|IhcA>? NGnXPGlFVVOR NYrVeW9oUUN3ME2xNEDPxE1? NUH4fWpSOjN6NESwN|g>
LS-174T MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHKWmcyOCEQvF2= M4LKR|czKGh? Mn7sSG1UVw>? MnjETWM2OD1zMDFOwG0> MXGyN|g1PDB|OB?=
A549 NXjTbHBjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXWxNEDPxE1? NFP5ZlY4OiCq Mm\hSG1UVw>? M2DHO2lEPTB;MUCg{txO NFfUblAzOzh2NECzPC=>
SHP-77 MnnIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjHTpMyOTBizszN M3j6Z|czKGh? MoXKSG1UVw>? MY\JR|UxRTFyIN88US=> NFHPUoYzOzh2NECzPC=>
SW480 NGLMbGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDnTXAyOCEQvF2= NGjFVG04OiCq NELPSYhFVVOR MoS0TWM2OD1zMDFOwG0> M1LLblI{QDR2MEO4
DLD-1 M3jMfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXVNVAh|ryP M3zoXVczKGh? M1z2PGROW09? NGjESY1KSzVyPUGwJO69VQ>? NHrqRYUzOzh2NECzPC=>
HCT-116 NE\nV2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\QNVAh|ryP NXHQXFFYPzJiaB?= M3jM[2ROW09? NGf6ZWdKSzVyPUGwJO69VQ>? NV;nVllJOjN6NESwN|g>
NCI-H747 NFzBZlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvXNVAh|ryP M{PkW|czKGh? MU\EUXNQ NYe3cHBLUUN3ME2xNEDPxE1? MlzaNlM5PDRyM{i=
T-84 MoTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1viclExKM7:TR?= M3nZTVczKGh? NVrKVoJNTE2VTx?= M{HhdGlEPTB;MUCg{txO MkjMNlM5PDRyM{i=
NCI-H460 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;Zc3lZOTBizszN MlzsO|IhcA>? NFv0OmFFVVOR MXHJR|UxRTFyIN88US=> M2PudVI{QDR2MEO4
Calu-6 NX\aNnB1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIf0fIUyOCEQvF2= NHf3NHo4OiCq MVnEUXNQ MW\JR|UxRTFyIN88US=> M2nC[lI{QDR2MEO4
HCC-2998 M4DPcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXixNEDPxE1? NFz1OWc4OiCq M1m3[mROW09? NHzP[4tKSzVyPUGwJO69VQ>? Mlv0NlM5PDRyM{i=
LS1034 NVSyRlNwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3DNphIOTBizszN MmTXO|IhcA>? MoHhSG1UVw>? MULJR|UxRTFyIN88US=> MYKyN|g1PDB|OB?=
CHP-212 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvJNVAh|ryP NWPofJV5PzJiaB?= NX3CXYt4TE2VTx?= MnG0TWM2OD1zMDFOwG0> M3;KbVI{QDR2MEO4
SK-N-AS MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fLS|ExKM7:TR?= MXG3NkBp NVfX[nZ3TE2VTx?= M{XTTGlEPTB;MUCg{txO NXnZe5BlOjN6NESwN|g>
BFTC-905 MkDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{K3[lExKM7:TR?= MnzaO|IhcA>? MnPoSG1UVw>? MY\JR|UxRTFyIN88US=> MnXWNlM5PDRyM{i=
HuT78 MmmzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlW2NVAh|ryP M1O1TVczKGh? MXTEUXNQ NXvSXoNCUUN3ME21NkBvVQ>? MonuNlM5PDRyM{i=
RPMI-8226 M3rJWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjZNVAh|ryP M4LoPVczKGh? NVLMbYxPTE2VTx?= MUTJR|UxRTJ4MzDuUS=> MW[yN|g1PDB|OB?=
BC-3 NXzxVG0{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfS[ngyOCEQvF2= MoPWO|IhcA>? MUDEUXNQ NWP2VZg{UUN3ME2yO|chdk1? MkezNlM5PDRyM{i=
ACHN NVLZdZBzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrCbJIyOCEQvF2= MYO3NkBp MXvEUXNQ MlrmTWM2OD1{OUSgcm0> NFrE[m4zOzh2NECzPC=>
JRT3-T35 NWj4RYg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGH5W5cyOCEQvF2= M{nsdFczKGh? NW\id|ZOTE2VTx?= M3fjRWlEPTB;Mkm1JI5O NYfPR5hxOjN6NESwN|g>
SK-MES-1 M3jzemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmj6NVAh|ryP MkTXO|IhcA>? M1uwWGROW09? MV;JR|UxRTN{OTDuUS=> NIPqbowzOzh2NECzPC=>
CESS Mmq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\ONVAh|ryP NHr0SXg4OiCq NYLS[|BNTE2VTx?= M{L3PGlEPTB;NEm3JI5O MlTiNlM5PDRyM{i=
H4 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1q5XVExKM7:TR?= NFjZUHo4OiCq MnKwSG1UVw>? NHjjWXJKSzVyPU[xPUBvVQ>? MlrFNlM5PDRyM{i=
BC-1 MlnqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYmxNEDPxE1? M1XPN|czKGh? MUjEUXNQ MlPZTWM2OD15MESgcm0> MlnWNlM5PDRyM{i=
DB NFX2Xm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7uOGMyOCEQvF2= MWm3NkBp NEO1flNFVVOR MXPJR|UxRTh5MzDuUS=> M376ZlI{QDR2MEO4
RPMI-6666 NV;GNYRNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTiN2cyOCEQvF2= MWe3NkBp NUXFbVd5TE2VTx?= NIfnOGZKSzVyPUmyPEBvVQ>? NHHUbHQzOzh2NECzPC=>
MC/CAR MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVuxNEDPxE1? NWTUc|ZpPzJiaB?= NFjiOGlFVVOR NFzDPW5KSzVyPUGuNFAzKM7:TR?= NEDoPJgzOzh2NECzPC=>
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647-V MmTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVmxNEDPxE1? M2KxZlczKGh? MVPEUXNQ NXPYbXh2UUN3ME2xNEDPxE1? NY\NXohSOjN6NESwN|g>
786-O NH;PdI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPpNVAh|ryP NFjiemE4OiCq MVTEUXNQ M4rFXGlEPTB;MUCg{txO M17iPFI{QDR2MEO4
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A427 Ml3WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWSxNEDPxE1? MoD0O|IhcA>? M1zGUmROW09? MluyTWM2OD1zMDFOwG0> NYno[mFxOjN6NESwN|g>
A431 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfqdI0yOCEQvF2= NG\YU2o4OiCq NEnFS|dFVVOR M{DhfmlEPTB;MUCg{txO NF\HZ44zOzh2NECzPC=>
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CAL-27 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVexNEDPxE1? MWS3NkBp MnT6SG1UVw>? MVrJR|UxRTFyIN88US=> NVzt[mxFOjN6NESwN|g>
CAL-62 Mom5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIX4NYoyOCEQvF2= NH3rb4g4OiCq M3OxTmROW09? MVjJR|UxRTFyIN88US=> M4jOZ|I{QDR2MEO4
Calu-3 NIPCZZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWKxNEDPxE1? MVe3NkBp M4TFPWROW09? MVnJR|UxRTFyIN88US=> NGDFeY4zOzh2NECzPC=>
CaOV3 MnrBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWSxNEDPxE1? NWTEWm1VPzJiaB?= NEToclNFVVOR NF7BbGVKSzVyPUGwJO69VQ>? NGm4UHIzOzh2NECzPC=>
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Colo320DM MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX6xNEDPxE1? Mk\LO|IhcA>? M3;mWmROW09? MYPJR|UxRTFyIN88US=> MXeyN|g1PDB|OB?=
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CRO-AP2 MoDzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1Ll[FExKM7:TR?= NIXVeI84OiCq MVnEUXNQ MV7JR|UxRTFyIN88US=> MUSyN|g1PDB|OB?=
Daudi M332UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmr2NVAh|ryP NE\EVJY4OiCq NGG0S5JFVVOR M4T2Z2lEPTB;MUCg{txO M3;pfVI{QDR2MEO4
DOTC 24510 NFy5Z3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\IO28yOCEQvF2= NWezOlR7PzJiaB?= NEP5SYdFVVOR MonmTWM2OD1zMDFOwG0> NI\r[lMzOzh2NECzPC=>
DU-145 M4nEfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LaT|ExKM7:TR?= NU\abIJGPzJiaB?= MknnSG1UVw>? MWfJR|UxRTFyIN88US=> MnzYNlM5PDRyM{i=
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Hep3B Mn\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGH0VJoyOCEQvF2= MWK3NkBp NWThVFFsTE2VTx?= NH7WdWpKSzVyPUGwJO69VQ>? M1X0N|I{QDR2MEO4
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HPAF-II M{W0Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTDXXA6OTBizszN NVjTXmsxPzJiaB?= NYfwbWF{TE2VTx?= M4XWN2lEPTB;MUCg{txO MX2yN|g1PDB|OB?=
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HT NGfZ[ZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LINlExKM7:TR?= M2HIOlczKGh? MmL3SG1UVw>? NF;T[ohKSzVyPUGwJO69VQ>? NH63R4wzOzh2NECzPC=>
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Kato III NV;vN|hRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjFSXZmOTBizszN NV\F[ItbPzJiaB?= MYnEUXNQ NWrSTmRqUUN3ME2xNEDPxE1? NFO0[pMzOzh2NECzPC=>
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KM-12 NGn0b3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLCNVAh|ryP NFjI[FE4OiCq M17RSGROW09? MoroTWM2OD1zMDFOwG0> MnvhNlM5PDRyM{i=
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KYSE-30 NEHBW4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrofYIyOCEQvF2= M3PkO|czKGh? M4HiNGROW09? MXrJR|UxRTFyIN88US=> Mmr5NlM5PDRyM{i=
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MDA-MB-175 VII MmXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnCc5oyOCEQvF2= NInJWoI4OiCq M17s[mROW09? MVvJR|UxRTFyIN88US=> MoPkNlM5PDRyM{i=
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MiaPaCa NUm5OXE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHv[WgyOCEQvF2= NYnGfpVtPzJiaB?= MoP6SG1UVw>? NVfG[phwUUN3ME2xNEDPxE1? MV:yN|g1PDB|OB?=
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NCI-H69 MnLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFj1eWMyOCEQvF2= M4\uWVczKGh? MlnKSG1UVw>? MVrJR|UxRTFyIN88US=> MViyN|g1PDB|OB?=
NCI-H82 NFi5PGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPrdmEyOCEQvF2= NEPoXYI4OiCq M3\icmROW09? MWPJR|UxRTFyIN88US=> MkftNlM5PDRyM{i=
NCI-N87 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfGTVVWOTBizszN MoHBO|IhcA>? M4X2NmROW09? NXrB[ow3UUN3ME2xNEDPxE1? NVHKdJdFOjN6NESwN|g>
NCI-H146 NHzvbWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXZVJAyOCEQvF2= NUXKXnhNPzJiaB?= MVLEUXNQ M3yzZmlEPTB;MUCg{txO M1\QUFI{QDR2MEO4
NCI-H157 Mk\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLhWnpWOTBizszN M4G2TFczKGh? MomzSG1UVw>? NYDPd3hOUUN3ME2xNEDPxE1? M{PkO|I{QDR2MEO4
NCI-H187 NWq4RVZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXKxNEDPxE1? MmiyO|IhcA>? NFfBTnRFVVOR MlzZTWM2OD1zMDFOwG0> NXixfo46OjN6NESwN|g>
NCI-H209 M2Oz[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrUPVZFOTBizszN NGPkZ3I4OiCq MX;EUXNQ NV60fFRZUUN3ME2xNEDPxE1? Moq1NlM5PDRyM{i=
NCI-H226 MlyyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX[xNEDPxE1? M3PGblczKGh? MmS2SG1UVw>? MnHYTWM2OD1zMDFOwG0> NGLzOXIzOzh2NECzPC=>
NCI-H292 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX2xNEDPxE1? M1;rfFczKGh? M1jBbGROW09? M1zlTGlEPTB;MUCg{txO MlrSNlM5PDRyM{i=
NCI-H322 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlG4NVAh|ryP NI[1Wlg4OiCq MoS1SG1UVw>? M4XQSmlEPTB;MUCg{txO M1Lhe|I{QDR2MEO4
NCI-H358 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjYToUzOTBizszN MYO3NkBp M{G0TmROW09? NX;lU2d4UUN3ME2xNEDPxE1? M1rKNlI{QDR2MEO4
NCI-H520 Ml7US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nYb|ExKM7:TR?= NYO1TFM1PzJiaB?= NIPEZoxFVVOR M1XURmlEPTB;MUCg{txO NGGxclgzOzh2NECzPC=>
NCI-H526 NW\LcY9WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPyNVAh|ryP M2XJWFczKGh? MnqySG1UVw>? MYPJR|UxRTFyIN88US=> NGfSZXIzOzh2NECzPC=>
NCI-H630 NWDrb2hlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrzOIEyOCEQvF2= MWO3NkBp NFrpSoRFVVOR NGjMZZlKSzVyPUGwJO69VQ>? NFL6fIgzOzh2NECzPC=>
NCI-H661 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFf0NpUyOCEQvF2= MoPQO|IhcA>? NGjGfGFFVVOR MmnRTWM2OD1zMDFOwG0> MnHmNlM5PDRyM{i=
NCI-H716 Mo\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjBWGFVOTBizszN MX63NkBp Ml35SG1UVw>? MUXJR|UxRTFyIN88US=> MW[yN|g1PDB|OB?=
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NCI-H1792 NYC0XmlrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jZUFExKM7:TR?= M{D6[|czKGh? MVzEUXNQ NF3QPIFKSzVyPUGwJO69VQ>? NW\vVYNJOjN6NESwN|g>
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... Click to View More Cell Line Experimental Data

体内研究 Dabrafenib(口服)抑制B-RafV600E突变的黑色素瘤(A375P)的生长,在免疫受损小鼠中皮下注射结肠癌(Colo205),Dabrafenib(口服)同样能抑制肿瘤生长。 [1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

溶解度 (25°C)

体外 DMSO 30 mg/mL (57.74 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
30% PEG400+0.5% Tween80+5% propylene glycol
8 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 519.56
化学式

C23H20F3N5O2S2

CAS号 1195765-45-7
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03794297 Not yet recruiting BRAF NP_004324.2:p.V600X|Erdheim-Chester Disease National Cancer Institute (NCI) January 12 2020 Phase 2
NCT03794297 Not yet recruiting BRAF NP_004324.2:p.V600X|Erdheim-Chester Disease National Cancer Institute (NCI) January 12 2020 Phase 2
NCT03784014 Not yet recruiting Soft Tissue Sarcoma Institut National de la Santé Et de la Recherche Médicale France|Commissariat A L''energie Atomique|Institut Bergonié|Plateforme labellisée Inca – Institut Bergonié Bordeaux|Plateforme labellisée Inca – Hôpital Européen Georges Pompidou Paris|CIC-EC 1401/EUCLID March 2019 Phase 3
NCT03784014 Not yet recruiting Soft Tissue Sarcoma Institut National de la Santé Et de la Recherche Médicale France|Commissariat A L''energie Atomique|Institut Bergonié|Plateforme labellisée Inca – Institut Bergonié Bordeaux|Plateforme labellisée Inca – Hôpital Européen Georges Pompidou Paris|CIC-EC 1401/EUCLID March 2019 Phase 3
NCT03272464 Recruiting Melanoma Massachusetts General Hospital|Incyte Corporation November 30 2018 Phase 1
NCT03272464 Recruiting Melanoma Massachusetts General Hospital|Incyte Corporation November 30 2018 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID