Nutlin-3a

目录号:S8059 别名: (-)-Nutlin-3

仅限科研使用

Nutlin-3a ((-)-Nutlin-3)是Nutlin-3的活性对映体,抑制p53/MDM2相互作用,无细胞试验中IC50为90 nM。Nutlin-3a 可诱导p53依赖的自噬和细胞凋亡。

Nutlin-3a Chemical Structure

CAS: 675576-98-4

规格 价格 库存 购买数量
10mM (1mL in DMSO) RMB 2923.83 现货
RMB 1624.68 现货
RMB 8084.33 现货
大包装 有超大折扣

今日订购,明日送达 全国免运费 分装免费 分装成小规格产品(单支最小为1mg)
如1支10mg产品可分装为10支1mg产品

全国免费电话:400-668-6834   |   Email:info@selleck.cn

客户使用Selleck生产的Nutlin-3a发表文献61篇:

产品安全说明书

MDM2/MDMX抑制剂选择性比较

相关MDM2/MDMX产品

生物活性

产品描述 Nutlin-3a ((-)-Nutlin-3)是Nutlin-3的活性对映体,抑制p53/MDM2相互作用,无细胞试验中IC50为90 nM。Nutlin-3a 可诱导p53依赖的自噬和细胞凋亡。
特性 高度选择性的MDM2抑制剂与对MDMX低得多的效果。对含野生型p53的肿瘤最有效。
靶点
p53-MDM2 interaction [3]
(Cell-free assay)
90 nM
体外研究

Nutlin-3α从MDM2蛋白的结合口袋置换p53,由此将p53从抑制和蛋白酶体降解状态释放出来,从而导致诱导其下游靶点,细胞周期停滞和细胞凋亡。七天孵育10 μM nutlin-3a导致了NIH3T3细胞的生长抑制达90%以上。[1] Nutlin-3α稳定并激活p53基因,以剂量依赖性的方式诱导p21的表达。[1] Nutlin-3A有效地减少S期细胞至0.2-2%,并增加了G1-和G2/M期细胞。[1] 在40小时后,Nutlin-3a诱导约60% SJSA-1和MHM细胞的凋亡,而到60小时后,凋亡细胞分别达到85%和65%。[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MV-4-11 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwNkGyN|ch|ryP MnexQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
H4 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTBwNk[yPEDPxE1? M3zEeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
PA-1 M2PDR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml[3TWM2OD1yLki3NFk3KM7:TR?= M3jRclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
NKM-1 NVLIcYp7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnvS3VKSzVyPUGuNFQ6OzFizszN Mle1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
NEC8 NHnNZ5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M323dmlEPTB;MT6yNVU4OiEQvF2= MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
EoL-1-cell M3PDcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILTTndKSzVyPUGuNlY4ODFizszN NGTwb489[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
K5 NFXmXYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1u2NmlEPTB;MT60NlA4OiEQvF2= MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
QIMR-WIL MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzxTWM2OD1zLk[wPFU1KM7:TR?= MorUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
MOLT-16 M1ToW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDLTWM2OD1zLke4OlA1KM7:TR?= MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
CHP-212 NGLKfWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPlTWM2OD1zLkixN|Y6KM7:TR?= MmW1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
CTB-1 M4jrO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTJwMEKyOFYh|ryP NEPqe3g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
MOLT-4 NV;jOFN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjjPXBKSzVyPUKuN|I5PTNizszN MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
A101D MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LX[2lEPTB;Mj6zOVAyKM7:TR?= MoHBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
DOHH-2 NYjjOoIzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1KyVmlEPTB;Mj60NlI4QSEQvF2= M1zmcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
ES4 NFTveZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrEVJBKSzVyPUKuOFMyPTVizszN M3PQTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
SW780 NWf5bVJ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHHTWM2OD1{LkWwPFg{KM7:TR?= NWKyZVFbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
VA-ES-BJ MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPUbpBKSzVyPUKuOVQyOSEQvF2= MmfSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
RPMI-8866 Mom4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknUTWM2OD1{LkW2NlE1KM7:TR?= M4PHUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
ML-2 NGDtdIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3[zNmlEPTB;Mj61OlU4PiEQvF2= M2njS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
MSTO-211H NHO0PZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jhRWlEPTB;Mj61O|Q2OSEQvF2= NVX5WGRsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
JVM-3 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TQcGlEPTB;Mj61PVMzPCEQvF2= MlvSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
A3-KAW MoHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\2cZFKSzVyPUKuOlE5OThizszN M4m0TFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
DK-MG NW\zN3FKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVq1bIFjUUN3ME2yMlYzPDdzIN88US=> NGDFVJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
LNCaP-Clone-FGC NIfiTFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\OZ41KSzVyPUKuOlQ{OThizszN Mmr6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
HT-144 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLNTWM2OD1{Lk[0OVc4KM7:TR?= NX\y[4RWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
NB69 NYLHOlJtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW[3SXRbUUN3ME2yMlY2OzN2IN88US=> NFqxVW09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
A172 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF65VFlKSzVyPUKuOlc2QDhizszN M3LiVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
RS4-11 NYPD[5dZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPYSoRTUUN3ME2yMlczPDB5IN88US=> NF;0WoI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
DU-4475 NIS5fotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rLXWlEPTB;Mj63PVUxOiEQvF2= NHPhNok9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
SJSA-1 NXXDUXhVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37DUmlEPTB;Mj64NlU2PiEQvF2= NYnidnI2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
BV-173 M3HyPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXEV|A{UUN3ME2yMlg1PDN7IN88US=> NVTrSGJsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
U-2-OS MoT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXqcGpKSzVyPUKuPVExPyEQvF2= MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
CHP-134 NUjYbo5OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWSwO45NUUN3ME2yMlk{QDh{IN88US=> M1vUXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
D-502MG MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTJwOUexOVQh|ryP MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
KS-1 NGfRflNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M375dGlEPTB;Mz6wNVYzOyEQvF2= MnnyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
A204 NVP6fG5JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTNwMEW1PFgh|ryP MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
KGN NUP6b4JVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTNwMEi0PVYh|ryP MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
NCI-H292 M4O2PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{ezR2lEPTB;Mz6xNlAzQCEQvF2= NXLiU25bRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
CAKI-1 MlqyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PvemlEPTB;Mz6xNlY6PCEQvF2= NUK2fW1iRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
C2BBe1 NV;oeppyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWP3OIJ2UUN3ME2zMlE4ODJ4IN88US=> NH3KUmM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
NB10 NFGyW3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXTdYVUUUN3ME2zMlIxQTZ4IN88US=> M4rxUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
MHH-NB-11 NEXJbmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTNwMk[4Nlch|ryP MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
NCI-SNU-1 NWTEOJZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;JTWM2OD1|LkK3PFQ{KM7:TR?= NW\YZnhHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
HCT-116 NXLwSGtLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3jUZd[UUN3ME2zMlMxOzN3IN88US=> NFnlU4k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
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MN-60 MmTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTPTWM2OD1|LkS0NFkzKM7:TR?= NWrnRnNGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
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RKO NIThcFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3DepFKSzVyPUOuOVM6OzZizszN MnTDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
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LB2241-RCC M36wOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfqTWM2OD1|Lk[1O|A5KM7:TR?= M4\ReFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
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NCI-H28 NEX4XmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XlRWlEPTB;ND62NlcyPyEQvF2= MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
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LS-513 M2\WT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2r1eWlEPTB;Nj63PVAzPiEQvF2= M4fXcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
A427 MofCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPOeHhOUUN3ME22Mlg4QDJ7IN88US=> MmrPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
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COLO-829 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\tWXRnUUN3ME23MlI1OTh6IN88US=> NVrJZnFYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
NCI-H1650 NGfYXVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkX6TWM2OD15LkO5NlI5KM7:TR?= NXf0eIduRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
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MCF7 NXr6bHVHSXCxcITvd4l{KGG|c3H5 NFW3e3I{KHWP NF7TOngzPCC2bzC3NkBpenN? MlG4TY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCPQ1[3JINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiCEY3ytfGwh\XiycnXzd4lwdiCuZY\lcEBifCB|IIXNJIFnfGW{IEK0JJRwKDd{IHjyd{BjgSCZZYP0[ZJvKGKub4T0bY5oKGGwYXz5d4l{ MnHuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6MEK3NVYoRjJ|OECyO|E3RC:jPh?=
MCF7 NV;SVlQ3SXCxcITvd4l{KGG|c3H5 M2Hj[VMhfU1? NXj1OIxYOjRidH:gO|IhcHK| MXfJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKE2FRkegZ4VtdHNiYYPz[ZN{\WRiYYOg[YFzdHliYYDvdJRwfGmlIHPlcIx{KGG2IEOgeW0h[W[2ZYKgNlQhfG9iN{KgbJJ{KGK7IHHucoV5cW5iVj3GTXREN3C{b4Dp[Il2dSCrb3Tp[IUhe3SjaX7pcoch[mG|ZXSgSmFEWyCobH;3JIN6fG:vZYTyfUApWn[kIE2gOEAmMQ>? M2XmOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OECyO|E3Lz5{M{iwNlcyPjxxYU6=
MCF7 NV6zb2dSSXCxcITvd4l{KGG|c3H5 NEPnR2s{KHWP MUWyOEB1dyB5MjDodpM> NG[1U5pKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJIh2dWGwIF3DSlch[2WubIOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5icEKxJIV5eHKnc4Ppc44hdGW4ZXygZZQhOyC3TTDh[pRmeiB{NDD0c{A4OiCqcoOgZpkhX2W|dHXyckBjdG:2dHnu[{BidmGueYPpdy=> MlW2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6MEK3NVYoRjJ|OECyO|E3RC:jPh?=
MCF7 MUTBdI9xfG:|aYOgZZN{[Xl? M{XRdFMhfU1? NYnhW2l5OjRidH:gO|IhcHK| Mk[5TY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCPQ1[3JINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKEKlbD34V{BmgHC{ZYPzbY9vKGyndnXsJIF1KDNidV2gZYZ1\XJiMkSgeI8hPzJiaILzJIJ6KFenc4Tldo4h[myxdITpcoch[W6jbInzbZM> NHrSUYQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{iwNlcyPid-MkO4NFI4OTZ:L3G+
MCF7 NUizUZAySXCxcITvd4l{KGG|c3H5 MmntOVAhdk1? MVuyOEB1dyB5MjDodpM> NYHaTVlpUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W|c3XkJIF{KGGlY4XteYxifGmxbjDv[kBk[XOyYYPlMVMh[2ynYY\h[4UheHKxZIXjeEBifCB3MDDuUUBi\nSncjCyOEB1dyB5MjDodpMh[nliV3XzeIVzdiCkbH;0eIlv\yCjbnHsfZNqew>? Mlj4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6MEK3NVYoRjJ|OECyO|E3RC:jPh?=
MCF7 MmD5R4VtdCCleXPs[UBie3OjeR?= MnnwN{B2VQ>? MU[yOEB1dyB5MjDodpM> MnP2R4VtdCCleXPs[UBienKnc4SgbY4hcHWvYX6gUWNHPyClZXzsd{Bie3Onc4Pl[EBieyCjY3P1cZVt[XSrb36gZZQhTzBxR{GgdIhie2ViYYSgN{B2VSCjZoTldkAzPCC2bzC3NkBpenNiYomgdJJweGmmaYXtJIlw\GmmZTDzeIFqdmmwZz3iZZNm\CCIQVPTJIFv[Wy7c3nz M3u5V|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OECyO|E3Lz5{M{iwNlcyPjxxYU6=
Assay
Methods Test Index PMID
Western blot p53 / MDM2 / p21 / Bax / Bak / Noxa / cleaved caspase / pro-caspase BMI-1 p53-Ser15 / p53-Ser37 / p53-Lys382 / MDM2 / CDC2 / PLK1 / HSC70 16014563 26887044 23666059
Immunofluorescence p-p21 / β-actin P53 Ac-p300 31083332 21394100 30240745
Growth inhibition assay Cell viability 26248031
体内研究 Nutlin-3α以剂量依赖性方式抑制异种移植物生长,在最高剂量(200毫克/千克)时表现大量的肿瘤收缩。Nutlin-3是p53途径在体内的选择性活化剂,并高度有效地抗SJSA-1骨肉瘤。有野生型p53和MDM2基因扩增的肿瘤对Nutlin-3α治疗应答最好。 [1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[3]
  • Biacore研究:

    竞争分析是在Biacore S51进行。甲系列S传感器芯片CM5衍生化用于固定一个PentaHis抗体来捕获His-标记的p53。捕获的水平是〜200响应单位(1单位响应对应于每毫米21 pg的蛋白质)。 MDM2蛋白的浓度被保持恒定在300 nM。将试验化合物溶解于10 mM DMSO中,并进一步稀释使每个MDM2测试样品中的浓度系列抑制剂。该试验是在25¡交流的电泳缓冲液(10 mM HEPES,0.15M的NaCl,2%DMSO)中运行。 MDM2-p53在抑制剂存在下的结合的计算方法是在没有抑制剂的结合的百分比,IC 50是使用微软EXCE计算。

细胞实验:[2]
  • Cell lines: OSA, T778, RMS13, U2OS, SaOS-2
  • Concentrations: ~5 μM
  • Incubation Time: 120小时
  • Method: SRB
动物实验:[1]
  • Animal Models: SJSA-1移植体
  • Dosages: 50, 100, 200 毫克/千克 每天两次
  • Administration: 口服

溶解度(25°C)

体外

体内

从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O

10mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 581.49
化学式

C30H30Cl2N4O4

CAS号 675576-98-4
储存条件 3年 -20°C 粉状
2年 -80°C 溶于溶剂

动物体内配方计算器(澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)

mg/kg g μL

第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于μL DMSO溶液(母液浓度mg/mL,:如该浓度超过该批次药物DMSO溶解度,请先联系Selleck);

体内配方配制方法:μL DMSO母液,加入μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入μL ddH2O,混匀澄清。

体内配方配制方法:μL DMSO母液,加入μL Corn oil,混匀澄清。

注意:1. 首先保证母液是澄清的;
2.一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。

摩尔浓度计算器

质量 浓度 体积 分子量

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

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常见问题及建议解决方法

问题 1:
What is the difference between S1061 (Nutlin-3) and S8059 (Nutlin-3a)?

回答:
S1061 is a racemic mixture of Nutlin3a and Nutlin3b. s8059 is the active enantiomer of Nutlin3.

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