Nutlin-3a

For research use only. Not for use in humans.

目录号:S8059 别名: (-)-Nutlin-3

Nutlin-3a Chemical Structure

CAS No. 675576-98-4

Nutlin-3a ((-)-Nutlin-3)是Nutlin-3的活性对映体,抑制p53/MDM2相互作用,无细胞试验中IC50为90 nM。Nutlin-3a 可诱导p53依赖的自噬和细胞凋亡。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 2923.83 现货
RMB 1624.68 现货
RMB 8084.33 现货
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客户使用Selleck生产的Nutlin-3a发表文献49篇:

产品安全说明书

Mdm2抑制剂选择性比较

生物活性

产品描述 Nutlin-3a ((-)-Nutlin-3)是Nutlin-3的活性对映体,抑制p53/MDM2相互作用,无细胞试验中IC50为90 nM。Nutlin-3a 可诱导p53依赖的自噬和细胞凋亡。
特性 高度选择性的MDM2抑制剂与对MDMX低得多的效果。对含野生型p53的肿瘤最有效。
靶点
p53/MDM2 interaction [3]
(Cell-free assay)
90 nM
体外研究

Nutlin-3α从MDM2蛋白的结合口袋置换p53,由此将p53从抑制和蛋白酶体降解状态释放出来,从而导致诱导其下游靶点,细胞周期停滞和细胞凋亡。七天孵育10 μM nutlin-3a导致了NIH3T3细胞的生长抑制达90%以上。[1] Nutlin-3α稳定并激活p53基因,以剂量依赖性的方式诱导p21的表达。[1] Nutlin-3A有效地减少S期细胞至0.2-2%,并增加了G1-和G2/M期细胞。[1] 在40小时后,Nutlin-3a诱导约60% SJSA-1和MHM细胞的凋亡,而到60小时后,凋亡细胞分别达到85%和65%。[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MV-4-11 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVu0VmVKUUN3ME2wMlYyOjN5IN88US=> M2S4NlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
H4 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjkXYJVUUN3ME2wMlY3OjhizszN MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
PA-1 NF:wbndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTBwOEewPVYh|ryP MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
NKM-1 M3TvNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTFwMES5N|Eh|ryP M4TIWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
NEC8 Mo\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\UTWM2OD1zLkKxOVczKM7:TR?= NWrJVlRuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
EoL-1-cell NHrO[JBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkf5TWM2OD1zLkK2O|AyKM7:TR?= NW[1ZoJmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
K5 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXxTWM2OD1zLkSyNFczKM7:TR?= M2PZXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
QIMR-WIL M3rhdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13rVWlEPTB;MT62NFg2PCEQvF2= MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
MOLT-16 M3\Bbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrRNVVKSzVyPUGuO|g3ODRizszN MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
CHP-212 NIrGNVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTFwOEGzOlkh|ryP NEnzPZo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
CTB-1 M{K3[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTYcpRKSzVyPUKuNFIzPDZizszN MmrxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
MOLT-4 NYHYWZJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTJwM{K4OVMh|ryP NI\pWJc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
A101D MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTJwM{WwNUDPxE1? MoDqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
DOHH-2 MoXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLJTWM2OD1{LkSyNlc6KM7:TR?= NHvNSZE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
ES4 NXzMNJVTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLrXld3UUN3ME2yMlQ{OTV3IN88US=> NHO3OFA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
SW780 M1fNdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmKxTWM2OD1{LkWwPFg{KM7:TR?= NV7IfZZURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
VA-ES-BJ NFrRUnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTXNZlKSzVyPUKuOVQyOSEQvF2= MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
RPMI-8866 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\RfZNGUUN3ME2yMlU3OjF2IN88US=> NXrBXoFKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
ML-2 NVXkXGxUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M162PWlEPTB;Mj61OlU4PiEQvF2= NXXISoY1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
MSTO-211H NFnMSIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfVTWM2OD1{LkW3OFUyKM7:TR?= NYrrd2w{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
JVM-3 NXHYR|llT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\aTWM2OD1{LkW5N|I1KM7:TR?= MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
A3-KAW M{O0SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HYSGlEPTB;Mj62NVgyQCEQvF2= MoLLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
DK-MG MnH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PTeGlEPTB;Mj62NlQ4OSEQvF2= NIPsVlk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
LNCaP-Clone-FGC MnfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfyS|d1UUN3ME2yMlY1OzF6IN88US=> NHrjcVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
HT-144 NVjWemJGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTJwNkS1O|ch|ryP MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
NB69 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{Ts[2lEPTB;Mj62OVM{PCEQvF2= MoC0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
A172 M3XZcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPjeFhKSzVyPUKuOlc2QDhizszN M4r2VFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
RS4-11 M4ixRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXNSXNsUUN3ME2yMlczPDB5IN88US=> Mn7tQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
DU-4475 NEDySZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvMbZRKSzVyPUKuO|k2ODJizszN M1HKTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
SJSA-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTJwOEK1OVYh|ryP NYjNe455RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
BV-173 NGfWO|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX[xS45OUUN3ME2yMlg1PDN7IN88US=> NGCwTYU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
U-2-OS NG[x[|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;BTWM2OD1{LkmxNFch|ryP NILkNpk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
CHP-134 MnjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{KwW2lEPTB;Mj65N|g5OiEQvF2= M{nZZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
D-502MG M3;XNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LlV2lEPTB;Mj65O|E2PCEQvF2= MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
KS-1 NX;1UFFUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHywNmhKSzVyPUOuNFE3OjNizszN NGflSWQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
A204 MnT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4GzbGlEPTB;Mz6wOVU5QCEQvF2= MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
KGN MmXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETBfYdKSzVyPUOuNFg1QTZizszN MnTRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
NCI-H292 M2HOOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlryTWM2OD1|LkGyNFI5KM7:TR?= M3zySFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
CAKI-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\PZYh7UUN3ME2zMlEzPjl2IN88US=> MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
C2BBe1 NVvMTmVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnXTWM2OD1|LkG3NFI3KM7:TR?= MoXyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
NB10 M2HXe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXn3WW8zUUN3ME2zMlIxQTZ4IN88US=> NGjaZ3A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
MHH-NB-11 M1fv[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTNwMk[4Nlch|ryP MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
NCI-SNU-1 NID6dZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTNwMke4OFMh|ryP MlLCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
HCT-116 MkHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLGdZdKSzVyPUOuN|A{OzVizszN NVnlSHdzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
G-401 NUPRVWNiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nHWmlEPTB;Mz6zOlMzOiEQvF2= MlLRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
MN-60 NIjlUG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzqdFFyUUN3ME2zMlQ1ODl{IN88US=> Ml3zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
SW982 NEHQSW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\FcnFNUUN3ME2zMlUxQDR6IN88US=> M2LTcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
RKO NFHHWnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrPXWwzUUN3ME2zMlU{QTN4IN88US=> NHHTOY89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
D-283MED NXzBTppWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrEe25kUUN3ME2zMlU4QTh4IN88US=> M4nJbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
LB996-RCC NXvwRYx5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHiTWM2OD1|Lk[yOVU5KM7:TR?= MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
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LB2241-RCC MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\mTWM2OD1|Lk[1O|A5KM7:TR?= M2CxRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
SK-HEP-1 M1rWbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmH0TWM2OD1|Lke0Nlk4KM7:TR?= NYDqT3NYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
G-402 M2XKeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nrSGlEPTB;Mz64NFg{OiEQvF2= NHzmcYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
GOTO MkPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHroe4VKSzVyPUOuPFQ{OzNizszN NWH5SY5qRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
LOXIMVI MkHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2r1UmlEPTB;Mz64OVY4PSEQvF2= NEPJVIQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
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CP50-MEL-B MkewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nScmlEPTB;ND6yOFM6OiEQvF2= MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
RH-18 MkO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkS3TWM2OD12LkK3O|A3KM7:TR?= MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
NB17 NHvTXWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTRwM{G3Olgh|ryP NYTOOFloRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
A375 M4XXWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF:5OG5KSzVyPUSuN|M2OjRizszN NXWwdmVKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
IST-MES1 MlvJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;pcJJKSzVyPUSuOFE1OTFizszN M4C5SlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
MZ2-MEL NGWxdZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorLTWM2OD12LkWwNVU2KM7:TR?= MoXhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
CAL-54 MmL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofjTWM2OD12LkWzNFE6KM7:TR?= NF;jeIk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
NCI-H28 MkXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnNfIRKSzVyPUSuOlI4OTdizszN M{K5fFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
D-247MG MmTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfVfHZKSzVyPUSuO|UxPzJizszN NXvCU5dwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
NCI-H460 NVzobm1tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPETmRnUUN3ME20MlkyOTJ5IN88US=> MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
MCF7 NGP1XplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjUeHZVUUN3ME21MlQ1OjR2IN88US=> MnvvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
697 M1f1dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIn0RYxKSzVyPUWuOFQ2PSEQvF2= Mn\iQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
ONS-76 NYf6XnRkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\OTWM2OD13LkW3NFA6KM7:TR?= MlrjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
C32 NV\URog4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfrTWM2OD13Lk[wNFI6KM7:TR?= M{XsPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
OS-RC-2 NXvaOm41T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrtTWM2OD13LkezPFg4KM7:TR?= MlfSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
MEL-HO NGPuVlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTVwOEW2Olch|ryP MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
LoVo Ml\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTZwMEG2NlQh|ryP M4j5cFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
AGS NH:yOHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rDUmlEPTB;Nj6xOFgzQCEQvF2= MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
GI-ME-N MoKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPoTWM2OD14LkKyOFIyKM7:TR?= NFTP[Gs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
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RVH-421 NHHENY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTZwNEK0Nlgh|ryP NGTicII9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
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NB5 NFywN49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLFfGtKUUN3ME22MlU3OTh|IN88US=> MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
NCI-H2122 NH\xbJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnGVpFKSzVyPU[uOVg4QTNizszN NWPpPVN{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
AM-38 NGS5XnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{CxfWlEPTB;Nj63OVY{QSEQvF2= MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
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LS-513 Mn;rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTZwN{mwNlYh|ryP NX\pUmI2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
A427 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LNeGlEPTB;Nj64O|gzQSEQvF2= NIjFOm89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
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COLO-829 Ml3rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml2zTWM2OD15LkK0NVg5KM7:TR?= NUDw[25bRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
NCI-H1650 NX71dpFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nwfWlEPTB;Nz6zPVIzQCEQvF2= MnX5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
NCI-H358 NYHBWIlHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIr4fFlKSzVyPUeuOFQ5PzlizszN NUW1WotmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
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MCF7 M{jsdGFxd3C2b4Ppd{Bie3OjeR?= MnntN{B2VQ>? M{noWVI1KHSxIEeyJIhzew>? MnvZTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCPQ1[3JINmdGy|IHHzd4V{e2WmIHHzJIViemy7IHHwc5B1d3SrYzDj[YxteyCjdDCzJJVOKGGodHXyJFI1KHSxIEeyJIhzeyCkeTDhco5mgGmwIG[tSmlVSy:ycn;wbYRqfW1iaX;kbYRmKHO2YXnubY5oKGKjc3XkJGZCS1NiZnzve{BkgXSxbXX0dpkhMFK4YjC9JFQhLSl? NIDZTXQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{iwNlcyPid-MkO4NFI4OTZ:L3G+
MCF7 Mof4RZBweHSxc3nzJIF{e2G7 NHr4S4c{KHWP M2\CVlI1KHSxIEeyJIhzew>? M134TGlv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iTVPGO{Bk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCyMkGg[ZhxemW|c3nvckBt\X[nbDDheEA{KHWPIHHmeIVzKDJ2IITvJFczKGi{czDifUBY\XO2ZYLuJIJtd3S2aX7nJIFv[Wy7c3nz M3XKVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OECyO|E3Lz5{M{iwNlcyPjxxYU6=
MCF7 NHLJTHVCeG:ydH;zbZMh[XO|YYm= Mn\0N{B2VQ>? Mn3jNlQhfG9iN{KgbJJ{ Mk\hTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCPQ1[3JINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKEKlbD34V{BmgHC{ZYPzbY9vKGyndnXsJIF1KDNidV2gZYZ1\XJiMkSgeI8hPzJiaILzJIJ6KFenc4Tldo4h[myxdITpcoch[W6jbInzbZM> Ml3qQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6MEK3NVYoRjJ|OECyO|E3RC:jPh?=
MCF7 NU\2[IZNSXCxcITvd4l{KGG|c3H5 NGTiNoc2OCCwTR?= NEfuNXczPCC2bzC3NkBpenN? Mm[2TY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCPQ1[3JINmdGy|IHHzd4V{e2WmIHHzJIFk[3WvdXzheIlwdiCxZjDjZZNx[XOnLUOgZ4xm[X[jZ3WgdJJw\HWldDDheEA2OCCwTTDh[pRmeiB{NDD0c{A4OiCqcoOgZpkhX2W|dHXyckBjdG:2dHnu[{BidmGueYPpdy=> M4jTOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OECyO|E3Lz5{M{iwNlcyPjxxYU6=
MCF7 MVLD[YxtKGO7Y3zlJIF{e2G7 MmXiN{B2VQ>? M33PSFI1KHSxIEeyJIhzew>? M4rYVWNmdGxiY4njcIUh[XK{ZYP0JIlvKGi3bXHuJG1ETjdiY3XscJMh[XO|ZYPz[YQh[XNiYXPjeY12dGG2aX;uJIF1KEdyL1exJJBp[XOnIHH0JFMhfU1iYX\0[ZIhOjRidH:gO|IhcHK|IHL5JJBzd3CrZHn1cUBqd2SrZHWgd5RicW6rbnetZoF{\WRiRlHDV{BidmGueYPpdy=> M3PaZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OECyO|E3Lz5{M{iwNlcyPjxxYU6=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p53 / MDM2 / p21 / Bax / Bak / Noxa / cleaved caspase / pro-caspase; 

PubMed: 16014563     


Expression of apoptosis- and cell-cycle–associated proteins in OCI-AML-3 cells, which were treated with 5 μM Nutlin-3a for the indicated times. Nutlin-3a induced increased protein expression of p53, MDM2, and p21 in OCI-AML-3 cells in a time-dependent fashion. Nutlin-3a induced Noxa, a BH3-only member of the Bcl-2 family, followed by caspase activation. β-actin was used to confirm equal loading of proteins. Arrowheads indicate cleared caspases.

BMI-1; 

PubMed: 26887044     


Western blot analysis of BMI-1 and actin was performed in BV-173, SUP-B15, NALM-6, NALM-19 and REH cell lines after 24 hours treatment with increasing concentrations of Nutlin-3a (1 μM, 2 μM, 5 μM) and with DMSO control. 

p53-Ser15 / p53-Ser37 / p53-Lys382 / MDM2 / CDC2 / PLK1 / HSC70; 

PubMed: 23666059     


Expression of the indicated proteins in whole-cell lysates of cells treated for 96 h with 50 μM resveratrol (R), 5 μM nutlin-3a (N), or co-treated with both substances (RN).

16014563 26887044 23666059
Immunofluorescence
p-p21 / β-actin; 

PubMed: 31083332     


Cells were treated with fluoride (5 mM) with/without Nutlin-3a for 24 h. p-p21 (green), nucleus (DAPI; blue) and β-actin (red) expression were detected by immunocytochemistry. Nutlin-3a addition augmented p-p21 expression compared to NaF treatment alone.

P53; 

PubMed: 21394100     


At 12 h following treatment with nutlin-3a, DoHH2 and MCA cells had increased levels of p53 visualized by immunofluorescence. p53 localization was predominantly nuclear. The 4',6-diamidino-2-phenylindole was used as counterstain of the nuclei.

Ac-p300; 

PubMed: 30240745     


HepG2 cells were treated with 5 μM Nutlin-3a for 24 hr, and the levels of Ac-p300 and p53 were assessed by co-immunofluorescence. Fluorescence intensity of Ac-p300 in control cells versus Nutlin-3a-treated cells have been quantified (represented as mean ± SD, unpaired two-tailed Student's t test, n = 50 of three independent experiments). Scale bar, 10 μm.

31083332 21394100 30240745
Growth inhibition assay
Cell viability; 

PubMed: 26248031     


All 15 cell lines were plated in 96-well plates. After 24h, media was exchanged and cells were treated with incremental concentrations of Nutlin-3a (1 μM, 5 μM, 10 μM, 25 μM, 50 μM, and 70 μM). After 72h of Nutlin-3a treatment, cell viability was measured by WST assay and compared to untreated control.

26248031
体内研究 Nutlin-3α以剂量依赖性方式抑制异种移植物生长,在最高剂量(200毫克/千克)时表现大量的肿瘤收缩。Nutlin-3是p53途径在体内的选择性活化剂,并高度有效地抗SJSA-1骨肉瘤。有野生型p53和MDM2基因扩增的肿瘤对Nutlin-3α治疗应答最好。 [1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[3]
- 合并

Biacore研究:

竞争分析是在Biacore S51进行。甲系列S传感器芯片CM5衍生化用于固定一个PentaHis抗体来捕获His-标记的p53。捕获的水平是〜200响应单位(1单位响应对应于每毫米21 pg的蛋白质)。 MDM2蛋白的浓度被保持恒定在300 nM。将试验化合物溶解于10 mM DMSO中,并进一步稀释使每个MDM2测试样品中的浓度系列抑制剂。该试验是在25¡交流的电泳缓冲液(10 mM HEPES,0.15M的NaCl,2%DMSO)中运行。 MDM2-p53在抑制剂存在下的结合的计算方法是在没有抑制剂的结合的百分比,IC 50是使用微软EXCE计算。
细胞实验:[2]
- 合并
  • Cell lines: OSA, T778, RMS13, U2OS, SaOS-2
  • Concentrations: ~5 μM
  • Incubation Time: 120小时
  • Method: SRB
    (Only for Reference)
动物实验:[1]
- 合并
  • Animal Models: SJSA-1移植体
  • Dosages: 50, 100, 200 毫克/千克 每天两次
  • Administration: 口服
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 100 mg/mL (171.97 mM)
Water Insoluble
Ethanol '100 mg/mL
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O
10mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 581.49
化学式

C30H30Cl2N4O4

CAS号 675576-98-4
储存条件 粉状
溶于溶剂
别名 (-)-Nutlin-3

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    What is the difference between S1061 (Nutlin-3) and S8059 (Nutlin-3a)?

  • 回答:

    S1061 is a racemic mixture of Nutlin3a and Nutlin3b. s8059 is the active enantiomer of Nutlin3.

Mdm2 Signaling Pathway Map

相关Mdm2产品

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID