Nutlin-3a

For research use only. Not for use in humans.

目录号:S8059 别名: (-)-Nutlin-3

Nutlin-3a Chemical Structure

CAS No. 675576-98-4

Nutlin-3a ((-)-Nutlin-3)是Nutlin-3的活性对映体,抑制p53/MDM2相互作用,无细胞试验中IC50为90 nM。Nutlin-3a 可诱导p53依赖的自噬和细胞凋亡。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 2923.83 现货
RMB 1624.68 现货
RMB 8084.33 现货
有超大折扣

今日订购,明日送达,全国免运费!

全国免费电话:400-668-6834   |   Email:info@selleck.cn

客户使用Selleck生产的Nutlin-3a发表文献48篇:

产品安全说明书

Mdm2抑制剂选择性比较

生物活性

产品描述 Nutlin-3a ((-)-Nutlin-3)是Nutlin-3的活性对映体,抑制p53/MDM2相互作用,无细胞试验中IC50为90 nM。Nutlin-3a 可诱导p53依赖的自噬和细胞凋亡。
特性 高度选择性的MDM2抑制剂与对MDMX低得多的效果。对含野生型p53的肿瘤最有效。
靶点
p53/MDM2 interaction [3]
(Cell-free assay)
90 nM
体外研究

Nutlin-3α从MDM2蛋白的结合口袋置换p53,由此将p53从抑制和蛋白酶体降解状态释放出来,从而导致诱导其下游靶点,细胞周期停滞和细胞凋亡。七天孵育10 μM nutlin-3a导致了NIH3T3细胞的生长抑制达90%以上。[1] Nutlin-3α稳定并激活p53基因,以剂量依赖性的方式诱导p21的表达。[1] Nutlin-3A有效地减少S期细胞至0.2-2%,并增加了G1-和G2/M期细胞。[1] 在40小时后,Nutlin-3a诱导约60% SJSA-1和MHM细胞的凋亡,而到60小时后,凋亡细胞分别达到85%和65%。[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MV-4-11 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLTdXhKSzVyPUCuOlEzOzdizszN M4TIS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
H4 M2LDdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XZSmlEPTB;MD62OlI5KM7:TR?= M3HnWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
PA-1 MmXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwOEewPVYh|ryP NIjQ[Xc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
NKM-1 Ml\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDCTWM2OD1zLkC0PVMyKM7:TR?= Moi2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
NEC8 NEntemxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XofmlEPTB;MT6yNVU4OiEQvF2= MlPBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
EoL-1-cell NWrUT5dWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HhOmlEPTB;MT6yOlcxOSEQvF2= NID3bGY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
K5 Mlz5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILCfXpKSzVyPUGuOFIxPzJizszN Mn7JQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
QIMR-WIL NHS2WYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTFwNkC4OVQh|ryP NH3oPJY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
MOLT-16 M3rLV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUT0UHltUUN3ME2xMlc5PjB2IN88US=> MnfoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
CHP-212 NVznOmxVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NES5UGFKSzVyPUGuPFE{PjlizszN Mn\pQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
CTB-1 NIHsTnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TtSmlEPTB;Mj6wNlI1PiEQvF2= NH7RU3A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
MOLT-4 NF\He2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XxUWlEPTB;Mj6zNlg2OyEQvF2= NUDRd4d6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
A101D MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTJwM{WwNUDPxE1? MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
DOHH-2 Mme1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPFSnVKSzVyPUKuOFIzPzlizszN NGjR[2Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
ES4 NYj6VZBiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEK3bYFKSzVyPUKuOFMyPTVizszN Mn3DQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
SW780 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXsSGZKSzVyPUKuOVA5QDNizszN NIjyW2M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
VA-ES-BJ MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoD1TWM2OD1{LkW0NVEh|ryP M3LmV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
RPMI-8866 NX3kcosyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLnTWM2OD1{LkW2NlE1KM7:TR?= NET6bYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
ML-2 MojBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXqeWhKSzVyPUKuOVY2PzZizszN NFjTOlk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
MSTO-211H M{DpZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFT1c|hKSzVyPUKuOVc1PTFizszN MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
JVM-3 M{DhOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LOb2lEPTB;Mj61PVMzPCEQvF2= MmXiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
A3-KAW Mlq0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUe0fIRPUUN3ME2yMlYyQDF6IN88US=> MnXnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
DK-MG MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjWOoNKSzVyPUKuOlI1PzFizszN NYTnN2RNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
LNCaP-Clone-FGC NX7qZ49rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHWW5ZKSzVyPUKuOlQ{OThizszN Mn36QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
HT-144 NULWTFByT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\MTZZVUUN3ME2yMlY1PTd5IN88US=> MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
NB69 MofUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTJwNkWzN|Qh|ryP M1nMblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
A172 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTJwNke1PFgh|ryP NYjpVno6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
RS4-11 NX[2NWlrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEi3NYNKSzVyPUKuO|I1ODdizszN M{jafFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
DU-4475 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTJwN{m1NFIh|ryP NEjYUmM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
SJSA-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TTUGlEPTB;Mj64NlU2PiEQvF2= NUfkcnd6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
BV-173 M4i5bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTJwOES0N|kh|ryP NFHZN5I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
U-2-OS MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDDTWM2OD1{LkmxNFch|ryP MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
CHP-134 NFHXVIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17Q[2lEPTB;Mj65N|g5OiEQvF2= MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
D-502MG NGq5OIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vLfmlEPTB;Mj65O|E2PCEQvF2= MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
KS-1 NEPXT4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2S3dGlEPTB;Mz6wNVYzOyEQvF2= MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
A204 NHX2SYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17SdGlEPTB;Mz6wOVU5QCEQvF2= M{WxSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
KGN NEj6cHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PpZWlEPTB;Mz6wPFQ6PiEQvF2= M33rRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
NCI-H292 MnjKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDXOJdoUUN3ME2zMlEzODJ6IN88US=> NUDZ[YljRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
CAKI-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nWPGlEPTB;Mz6xNlY6PCEQvF2= NI\0b4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
C2BBe1 M2jibGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHn1fVFKSzVyPUOuNVcxOjZizszN M1:yN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
NB10 MnnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrlTWM2OD1|LkKwPVY3KM7:TR?= NUfVXpZjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
MHH-NB-11 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTNwMk[4Nlch|ryP MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
NCI-SNU-1 M3fXW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjQTWM2OD1|LkK3PFQ{KM7:TR?= NH7rTHk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
HCT-116 M3XPV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTNwM{CzN|Uh|ryP NH;Y[Xc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
G-401 MkDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jx[WlEPTB;Mz6zOlMzOiEQvF2= M4n3c|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
MN-60 NH\JN5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\hbFFKSzVyPUOuOFQxQTJizszN M4jwflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
SW982 NXvzcIp3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjOfHhKSzVyPUOuOVA5PDhizszN MoKzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
RKO NGXhfGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XkeWlEPTB;Mz61N|k{PiEQvF2= NIS1S5A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
D-283MED MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfsXI9KSzVyPUOuOVc6QDZizszN MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
LB996-RCC MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\STWM2OD1|Lk[yOVU5KM7:TR?= NFj1VIQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
A549 NVzjcXZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDxO|ZXUUN3ME2zMlY{PTV{IN88US=> M4PuXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
LB2241-RCC MmWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTNwNkW3NFgh|ryP NUHPU4RYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
SK-HEP-1 NXPWUnpUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnf5TWM2OD1|Lke0Nlk4KM7:TR?= MmrsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
G-402 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\tTWM2OD1|LkiwPFMzKM7:TR?= NH7qfXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
GOTO Ml;KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jKcWlEPTB;Mz64OFM{OyEQvF2= NX34bJNoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
LOXIMVI MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTNwOEW2O|Uh|ryP Mn;HQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
NH-12 NVGyS5NlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPiTWM2OD12LkCxPVU6KM7:TR?= M2nlPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
CTV-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULmSHg6UUN3ME20MlA4QTd|IN88US=> MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
CP50-MEL-B NILkd3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTRwMkSzPVIh|ryP NInYSZA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
RH-18 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTRwMke3NFYh|ryP MoTNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
NB17 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTRwM{G3Olgh|ryP NHu0cXU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
A375 NVLRdJdKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXaTWM2OD12LkOzOVI1KM7:TR?= NUPxVJpuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
IST-MES1 NILQ[npIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XnbmlEPTB;ND60NVQyOSEQvF2= M33xPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
MZ2-MEL MoXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPxWWl[UUN3ME20MlUxOTV3IN88US=> Mk\0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
CAL-54 Mn;xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWe0S3M3UUN3ME20MlU{ODF7IN88US=> MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
NCI-H28 NU[zbGtxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTRwNkK3NVch|ryP NYGxV|k{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
D-247MG M2DUTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;nNoc1UUN3ME20Mlc2ODd{IN88US=> M2HrblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
NCI-H460 NIXZdWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIS5WpRKSzVyPUSuPVEyOjdizszN MkTKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
MCF7 NGHRR3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTVwNESyOFQh|ryP NYTiTlZ6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
697 MkDkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzxVJJKSzVyPUWuOFQ2PSEQvF2= M1:xS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
ONS-76 MknFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\EPGlEPTB;NT61O|AxQSEQvF2= NVvUclBVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
C32 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zPe2lEPTB;NT62NFAzQSEQvF2= MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
OS-RC-2 NFXKbIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnOOnlKUUN3ME21Mlc{QDh5IN88US=> MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
MEL-HO M2LmZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTVwOEW2Olch|ryP MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
LoVo NGrYTnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTZwMEG2NlQh|ryP NULDcW1TRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
AGS M{P4cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVezUnd{UUN3ME22MlE1QDJ6IN88US=> MlfCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
GI-ME-N NW\wbpJqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFH4V2dKSzVyPU[uNlI1OjFizszN NUHvflJIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
H-EMC-SS NWTseYQ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPseFlKSzVyPU[uN|g3KM7:TR?= MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
RVH-421 MlL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\5UmRmUUN3ME22MlQzPDJ6IN88US=> M4H1TFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
SW954 MnPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX34XYFNUUN3ME22MlU2PTd{IN88US=> M2PHb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
NB5 NULIfGFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\tZXREUUN3ME22MlU3OTh|IN88US=> M170RlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
NCI-H2122 NIfRbXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLXbIQ3UUN3ME22MlU5Pzl|IN88US=> NWTrT|JiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
AM-38 M4W5WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXyO2FKSzVyPU[uO|U3OzlizszN NUW1UZoyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
KNS-81-FD M4HndGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTZwN{[0PVQh|ryP M4r1NFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
LS-513 MlnWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIq5UmhKSzVyPU[uO|kxOjZizszN MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
A427 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzZTWM2OD14Lki3PFI6KM7:TR?= MoS5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
WM-115 MmPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHn4dnNKSzVyPU[uPVMzOyEQvF2= NEDOOIs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
COLO-829 MlPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnNU5FGUUN3ME23MlI1OTh6IN88US=> MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
NCI-H1650 NVLTbHlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jHcmlEPTB;Nz6zPVIzQCEQvF2= MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
NCI-H358 NGjmWJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXS[JpRUUN3ME23MlQ1QDd7IN88US=> NUjXUGFyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
HT-1080 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrNSXJ6UUN3ME23MlQ5OjV2IN88US=> M4KwSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
HCC2218 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFqwcpRKSzVyPUeuOlI6PyEQvF2= NWPRfVNLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
NCI-H661 NUT2dmlQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTdwOEewOlkh|ryP MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
KM-H2 NF7teo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTdwOEi2PVQh|ryP NU\ZXpk6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
RPMI-2650 NWrD[XJtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTdwOUS0NVQh|ryP M17pcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
NCI-H226 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDJNVRKSzVyPUiuNlEyOjJizszN MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
MKN45 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV20dm5xUUN3ME24MlI3PjB{IN88US=> MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
D-392MG NFHOfnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHOTWM2OD16LkWyO|IzKM7:TR?= M3vSfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
RCC10RGB M1LyR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfQeGtDUUN3ME24Mlg3Pjl3IN88US=> NV7OeHljRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
CAL-51 M3LRfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTlwMUCyOVEh|ryP NI\4R5g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
COLO-678 Mny4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fEbGlEPTB;OT6zNlgyOSEQvF2= MnfFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
SK-MEL-24 NIjPeHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTlwNUW4OVYh|ryP NXToWGo{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
SK-MEL-30 NIfvUFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\yNYVsUUN3ME25Mlk1PDd4IN88US=> MnfFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
MMAC-SF NWXpV2ZUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nVUmlEPTB;MUCuN|k3OSEQvF2= NVzTXYY6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
NTERA-S-cl-D1 NUC0b5hKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPiSlRKSzVyPUGwMlY2ODhizszN M{H6NlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
NB12 NFvxd4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\aeVQxUUN3ME2xNU42ODNizszN NHfLdVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
UACC-257 M{DyXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4n5dGlEPTB;MUGuPFY6PSEQvF2= M3z0ZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
LAN-6 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\Ve2lEPTB;MUGuPVkzQCEQvF2= NHzsOlk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
SW1573 M4D3T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTvTWM2OD1zMj6zNFg3KM7:TR?= NWjVWFhbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
NMC-G1 MnvMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzpOHc1UUN3ME2xNk41OTd3IN88US=> MnPVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
SHP-77 NE\3elRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\ZU25KSzVyPUGyMlU2PzRizszN MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
IGROV-1 MkLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTF{Lk[1O|Mh|ryP NWDqSHB1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
22RV1 MnjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLTTWM2OD1zMj64NFU6KM7:TR?= MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
SK-MEL-3 NFnJbXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfNTWM2OD1zMz6zPVc{KM7:TR?= Mn7CQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
NCI-H1563 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTF|LkSyNFIh|ryP MofQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
IGR-1 NVXETGlNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moj3TWM2OD1zND6wN|Q4KM7:TR?= NWmzTGM2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
EW-3 MmW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvsZmlwUUN3ME2xOE4yPjN7IN88US=> NGnqZ489[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
JEG-3 M4PLUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\qcmlEPTB;MUSuOFk2OyEQvF2= NUS4VGdQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
ES3 M2rmZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHWPZBjUUN3ME2xOE43PTZ{IN88US=> NVflU|ZXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
MDA-MB-175-VII MmK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HBNWlEPTB;MUSuO|EyOSEQvF2= M17BOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
P30-OHK MnTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\QTWM2OD1zNT6wOFk3KM7:TR?= NIDKT2g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
GP5d MlrsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml60TWM2OD1zNT6xOFY3KM7:TR?= NX3zZ25jRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
HMV-II MmnWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LZcmlEPTB;MUWuN|M{OyEQvF2= MofYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
COLO-679 M1faZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjCU3RRUUN3ME2xOU42ODFizszN M{jkOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
JAR NE\SdJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTF3LkeyNFUh|ryP NUPl[lA6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
NCI-H1666 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTF3LkmzPVkh|ryP NWXtNVh5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
SW48 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXVd2tYUUN3ME2xOU46PTF4IN88US=> NFrseoI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
NCI-H720 M2DwTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPU[WQxUUN3ME2xOU46QTh7IN88US=> NW\rbmxIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
HT-1197 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnNd|BLUUN3ME2xOk4xOzV{IN88US=> NVXKRo5QRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
HL-60 NHLxT|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPEcol3UUN3ME2xOk4xOzh2IN88US=> NX2yPXlLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
BEN M3jzS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfMfZZKSzVyPUG2MlU3OzhizszN MkLyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
HAL-01 NXLoVVhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PKb2lEPTB;MU[uPFkxQSEQvF2= MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
SW900 NV;ncZd5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIP1NIdKSzVyPUG2MlkyOzJizszN MkLyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
SBC-1 MlL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTF5LkW0Nlkh|ryP M3\VWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
SH-4 MkPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTF5LkW4OFEh|ryP MnvVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
UACC-62 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17tbGlEPTB;MUeuO|Y{PyEQvF2= NUPIU21ZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
BHT-101 M2jEXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHtTWM2OD1zOT64O|A2KM7:TR?= NV\ZcFdnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
DB MnzYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fHXmlEPTB;MkGuOVY1QSEQvF2= NFn1eWc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
SK-MEL-1 NFSyVpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWOwSWtEUUN3ME2yNU42QDd{IN88US=> MlL2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
NCI-H747 NW\HT2lRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\4ZWlEPTB;MkKuO|M4QSEQvF2= MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
SK-LU-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV75NHVsUUN3ME2yN{4{PTJ2IN88US=> M33VOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
KG-1 NXLQNVVLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13mUGlEPTB;MkOuOFk1PiEQvF2= MkC5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
LXF-289 NYmzenhyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MomwTWM2OD1{Mz63NVQh|ryP M4rrNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
HCC1954 NVO2PGl6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fGNWlEPTB;MkSuPFg1PCEQvF2= M1zv[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
Ramos-2G6-4C10 MmP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXmU|hYUUN3ME2yOk41QThzIN88US=> MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
DBTRG-05MG NGnmSW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTJeHJGUUN3ME2yOk43PDh6IN88US=> NEnsTWc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
NCI-H2052 M4rPVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIftfpFKSzVyPUK3MlU3QDRizszN M{\qU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
RMG-I MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTJ7LkSxN|kh|ryP MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
H9 NX\QZZVyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HjW2lEPTB;M{GuN|AxQCEQvF2= NH;Dc289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
GR-ST MoHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnYVWhKSzVyPUOyMlQ1PTNizszN NH7VXFY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
Mo-T MknxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\CU3lkUUN3ME2zNk42ODR4IN88US=> NFX4ZVM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
SW1088 NIWxSpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2T1[GlEPTB;M{KuPVgxOSEQvF2= NVj2dJZFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
LB2518-MEL MnrUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnL3TWM2OD1|Mz6wO|k4KM7:TR?= M4TEdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
NCI-H82 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHFNpI2UUN3ME2zN{4yPjZzIN88US=> M4PtNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
LAMA-84 NWG4b2dET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTkVGxKSzVyPUO0MlYxPzNizszN NHnSfnY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
KYSE-450 MlfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTN2Lk[3O|Yh|ryP MnPYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
LU-99A M33HVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\TR3lKSzVyPUO1MlAxODdizszN NYLLWZNsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
BE-13 MnfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvpUVBKSzVyPUO1MlY2PDVizszN NHv2clY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
GAK MmnHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTN3Lk[5OUDPxE1? MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
NCI-H1573 NYO0WoY2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTN3Lki4NVgh|ryP M1;BVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
AsPC-1 Ml7oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTZXJM6UUN3ME2zOk4yPTJ5IN88US=> NWHCVY8{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
HDLM-2 NIrURmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGq1NFlKSzVyPUO2MlMyPiEQvF2= NIHkc289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
NCI-H441 M1HLVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIH2XpRKSzVyPUO3MlA3QTFizszN NVzPZ3Z1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
CAL-27 NEH2W2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoToTWM2OD1|Nz63NlMyKM7:TR?= MnTOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
OVCAR-3 NGD4R5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\TbGlEPTB;M{muN|E5OSEQvF2= MoOwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
RPMI-8226 NFnxUmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{X4VGlEPTB;M{muOVk5KM7:TR?= M{W1d|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
EFO-21 M3jOS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvkbpFKSzVyPUSwMlU5OTRizszN M{HRTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
SNU-C2B MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{K3VmlEPTB;NEGuOVA5PCEQvF2= NWDESHZnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,W0GQR1XSQE9iRg>?
VM-CUB-1 NHO2dW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HzNWlEPTB;NEOuPFA{PyEQvF2= NFvUZok9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
NCI-H2087 NVzkcFdkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrRXnhUUUN3ME20OU4xOjN|IN88US=> NH\nVJY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
EW-16 NIT1enBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfUTWM2OD12Nj6zNVM4KM7:TR?= M2TNZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
SK-N-AS NFfWbWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrGTWM2OD12Nj63NVY4KM7:TR?= MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
COR-L105 M1G1UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLYNYZKSzVyPUS2Mlg5PTdizszN Mmi2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+V2FPT0WUPD;hQi=>
DEL MlrpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PC[GlEPTB;NEiuNFQzQSEQvF2= MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7TRW5ITVJ:L3G+
JVM-2 NUn3[WZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2mwemlEPTB;NEiuNFU2QCEQvF2= NH;iVGM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQTF|M{SvK|5USU6JRWK8M4E,
KARPAS-45 NYX5S282T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmflTWM2OD12OT60OVM5KM7:TR?= M3nQRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQnNCVkeHUkyvZV4>
BL21 (DE3) NF3XdFZHfW6ldHnvckBie3OjeR?= MoGxRolv\GmwZzDh[oZqdmm2eTD0c{BpfW2jbjDy[YNwdWKrbnHueEBO\G1{IGSxNFFYKG23dHHueEBmgHC{ZYPz[YQhcW5iRYPjbIVzcWOqaXGgZ49tcSCETEKxJEhFTTNrIHPlcIx{KGK7IHHueIFod26rc4SgbY5lfWOnZDDkbZN{d2OrYYTpc44h[XO|YYmsJGtlKD1iMD61JO69VS5? MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDZ6MEK3NUc,OTh4OECyO|E9N2F-
BL21 (DE3) NGXCZVVHfW6ldHnvckBie3OjeR?= MnH0Rolv\GmwZzDh[oZqdmm2eTD0c{BpfW2jbjDy[YNwdWKrbnHueEBO\G1{IFu5PHchdXW2YX70JIV5eHKnc4Pl[EBqdiCHc3Po[ZJq[2irYTDjc4xqKEKOMkGgLGRGOyliY3XscJMh[nliYX70ZYdwdmm|dDDpcoR2[2WmIHTpd5Nw[2mjdHnvckBie3OjeTygT4QhRSByLkWg{txONg>? MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDZ6MEK3NUc,OTh4OECyO|E9N2F-
BL21 (DE3) NGn2UpVHfW6ldHnvckBie3OjeR?= NIOyTYpDcW6maX7nJIFn\mmwaYT5JJRwKGi3bXHuJJJm[2:vYnnuZY51KE2mbUKgSlU2XyCvdYThcpQh\XiycnXzd4VlKGmwIFXzZ4hmemmlaHnhJINwdGliQlyyNUApTEV|KTDj[YxteyCkeTDOUXIhdGmpYX7kMZBzd3SnaX6gZolv[XK7IITpeJJifGmxbjygT4QhRSByLkWg{txONg>? Mn[1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh4OECyO|EoRjF6NkiwNlcyRC:jPh?=
SJSA1 MVHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NYjhNHpuOyCmYYnz MnraRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCVSmPBNUBk\WyuczDh[pRmeiB|IHThfZMh[nliRXTVJIlv[2:{cH;yZZRqd25iYYPzZZkhcW5icILld4Vv[2Vib3[gNVAmKGi3bXHuJJNmenWvLDDJR|UxKD1iMD63JO69VS5? NVyxbnhmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK1NlQ2OjdpPkKyOVI1PTJ5PD;hQi=>
HCT116 MnvsSpVv[3Srb36gZZN{[Xl? MYGyOEBpenN? NH\6R|FKdmS3Y4Tpc44hd2ZicEWzMXNmejF3IIDoc5NxcG:{eXzheIlwdiCrbjDoeY1idiCKQ2SxNVYh[2WubIOgZYZ1\XJiMkSgbJJ{NCCLQ{WwJF0hOSEQvF2u MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTh3NkmyNEc,OTl6NU[5NlA9N2F-
BL21 (DE3) M3HBfGZ2dmO2aX;uJIF{e2G7 Mnu1Rolv\GmwZzDh[oZqdmm2eTD0c{BpfW2jbjDy[YNwdWKrbnHueEBO\G1{IGSxNFFYKG23dHHueEBmgHC{ZYPz[YQhcW5iRYPjbIVzcWOqaXGgZ49tcSCETEKxJEhFTTNrIHPlcIx{KGK7IF7NVkBtcWejbnStdJJwfGWrbjDibY5ienlidHn0doF1cW:wLDDL[EA:KDFizszNMi=> NHPHOlE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOE[4NFI4OSd-MUi2PFAzPzF:L3G+
BL21 (DE3) NWi0fXNjTnWwY4Tpc44h[XO|YYm= M1fp[GJqdmSrbnegZYZncW6rdImgeI8hcHWvYX6gdoVkd22kaX7hcpQhVWSvMjDLPVhYKG23dHHueEBmgHC{ZYPz[YQhcW5iRYPjbIVzcWOqaXGgZ49tcSCETEKxJEhFTTNrIHPlcIx{KGK7IF7NVkBtcWejbnStdJJwfGWrbjDibY5ienlidHn0doF1cW:wLDDL[EA:KDFizszNMi=> NGfu[|Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOE[4NFI4OSd-MUi2PFAzPzF:L3G+
SJSA1 NFXn[YxEgXSxdH;4bYNqfHliYYPzZZk> MULDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTTnNCOSClZXzsd{whUUN3MDC9JFEh|ryPLh?= NWfYTGhxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWzPVY{OjBpPkK1N|k3OzJyPD;hQi=>
RKO NETqbXdEgXSxdH;4bYNqfHliYYPzZZk> Mn7yR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVmtQKGOnbHzzMEBKSzVyIE2gNUDPxE1w NEDjO3U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUO5OlMzOCd-MkWzPVY{OjB:L3G+
HCT116 NIXDXnBEgXSxdH;4bYNqfHliYYPzZZk> MWjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMtKEmFNUCgQUAyKM7:TT6= MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTN7NkOyNEc,OjV|OU[zNlA9N2F-
SJSA1 NVHLNm9oT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYfuZm1RT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hW0qVQUGgZ4VtdHNiZYjwdoV{e2mwZzDNSG0zKGK7IGPSRkBie3OjeTygS2k2OCB;IEGuN{DPxE1w MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTh5NUiwNUc,OjF6N{W4NFE9N2F-
HCT116 M{LVUGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MnPQO|IhcHK| NIXYUmVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFEyPiClZXzsd{BmgHC{ZYPzbY5oKHerbHSgeJlx\SCyNUOgbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTTJIF{e2G7LDDJR|UxKD1iMT6zJO69VS5? MljvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MkG5N|UoRjNyMkKxPVM2RC:jPh?=
HCT116 MnGySpVv[3Srb36gZZN{[Xl? NFXr[Hk5KGi{cx?= MXXJcoR2[3Srb36gc4YheDV|IHnuJIh2dWGwIFjDWFEyPiClZXzsd{Bkd2W6cILld5NqdmdicIC1N3RCNWy3YzDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHPlcIwheHKxbHnm[ZJifGmxbjDh[pRmeiB6IHjyd{BjgSCoaYLl[ox6N3KnbnnscIEhdHWlaX\ldoF{\SC{ZYDvdpRmeiCjc4PhfUwhUUN3MDC9JFEvOzlizszNMi=> Ml[2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl6NU[5NlAoRjF7OEW2PVIxRC:jPh?=
HGF MkC0R5l1d3SxeHnjbZR6KGG|c3H5 MnP5NlQhcHK| MWfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIS2Yh[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEGuOEDPxE1w M4PwTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OECyO|E3Lz5{M{iwNlcyPjxxYU6=
SJSA1 NEPESm1CdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M3nLNFczKGi{cx?= NYjV[XdwSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTTnNCOSClZXzsd{BmgHC{ZYPzbY5oKHerbHSgeJlx\SCyNUOgbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTTJIF{e2G7LDDJR|UxKD1iMT60OEDPxE1w NGX6bpU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEKyNVk{PSd-M{CyNlE6OzV:L3G+
SJSA1 NYXRVnZLS3m2b4TvfIlkcXS7IHHzd4F6 MmnJOUBl[Xm| M{LEVWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNLW0FzIHPlcIx{KGW6cILld5Nqdmdid3ns[EB1gXCnIIC1N{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjC1JIRigXNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNU42KM7:TT6= M1jxO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUCwOlk1Lz5{NEmwNFY6PDxxYU6=
RKO M3LKeWN6fG:2b4jpZ4l1gSCjc4PhfS=> NFriXZY2KGSjeYO= MUfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDST28h[2WubIOg[ZhxemW|c3nu[{B4cWymIIT5dIUheDV|IHHzd4V{e2WmIHHzJINmdGxidnnhZoltcXS7IHHmeIVzKDViZHH5d{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzLkWg{txONg>? M2TpO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUCwOlk1Lz5{NEmwNFY6PDxxYU6=
HCT116 MXLDfZRwfG:6aXPpeJkh[XO|YYm= Mmq5OUBl[Xm| NFHUenNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJS1RzMU[gZ4VtdHNiZYjwdoV{e2mwZzD3bYxlKHS7cHWgdFU{KGG|c3Xzd4VlKGG|IHPlcIwhfmmjYnnsbZR6KGGodHXyJFUh\GG7czDifUBOXFRiYYPzZZktKEmFNUCgQUAyNjVizszNMi=> MmnYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7MEC2PVQoRjJ2OUCwOlk1RC:jPh?=
A2780 MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmrDS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gRVI4QDBiY3XscJMh\XiycnXzd4lv\yCPRF2yJIJ6KFOUQjDhd5NigSxiR1m1NEA:KDFwNjFOwG0v MmrFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6N{W4NFEoRjJzOEe1PFAyRC:jPh?=
HCT116 M4DpWGN6fG:2b4jpZ4l1gSCjc4PhfS=> MmG4O|IhcHK| MYrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JGNmdGyWaYTldmdtdyCudXPp[oVz[XOnLXLhd4VlKGG|c3H5MEBKSzVyIE2gNU43KM7:TT6= MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDF|OUi0OUc,OjRzM{m4OFU9N2F-
SJSA1 M{Xpd2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 M1rLTGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iU1rTRVEh[2WubIOsJGlEPTBiPTCxMlkh|ryPLh?= NXHNUotORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2OVY3PjFpPkK0OlU3PjZzPD;hQi=>
SJSA1 NYnDOZlSSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MVq3NkBpenN? MV3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFOMU1GxJINmdGy|IHX4dJJme3Orbnege4lt\CC2eYDlJJA2OyCjZoTldkA4OiCqcoOgZpkhS2WubGTpeJJmNUeubzDhd5NigSxiSVO1NEA:KDFwOTFOwG0v MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjl6NUOyN{c,OjZ7OEWzNlM9N2F-
HCT116 M1:yWmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmrKS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gTGNVOTF4IHPlcIx{KGW6cILld5NqdmdiTVTNNkBjgSCVUlKgZZN{[XluIFfJOVAhRSB{LkGg{txONg>? MmC4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6N{W4NFEoRjJzOEe1PFAyRC:jPh?=
NGP Mnf3R5l1d3SxeHnjbZR6KGG|c3H5 M2j0bFczKGi{cx?= M2HSUWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5IWCClZXzsd{Bi\nSncjC3NkBpenNiYomgd5Vt\m:{aH;kZY1qdmViQjDhd5NigSxiR1m1NEA:KDJwMTFOwG0v NVPQW4ZpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzNVQyOjhpPkKxN|E1OTJ6PD;hQi=>
LS NXzERWRKS3m2b4TvfIlkcXS7IHHzd4F6 NVjVepdnPzJiaILz MlXTR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUHMh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IIP1cIZwemixZHHtbY5mKEJiYYPzZZktKEeLNUCgQUAzNjNizszNMi=> NELMUVY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUOxOFEzQCd-MkGzNVQyOjh:L3G+
SJSA1 NWLXV2FtS3m2b4TvfIlkcXS7IHHzd4F6 M{PWfVczKGi{cx?= NVHlRnB2S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0qVQUGgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[XO|YYmsJGdKPTBiPTCyMlYh|ryPLh?= M3XMNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzM{G0NVI5Lz5{MUOxOFEzQDxxYU6=
MCF7 MXHDfZRwfG:6aXPpeJkh[XO|YYm= NEXwWWszPCCqcoO= MV\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyMlkh|ryPLh?= MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzhyMkexOkc,OjN6MEK3NVY9N2F-
HCT116 MVfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NWLWPGhbPzJiaILz NHPPfY9CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBqdiCyNUOgLEswMyliaIXtZY4hUEOWMUG2JINmdGy|IHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KE2WUzDhd5NigSxiSVO1NEA:KDRizszNMi=> M4[yb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUi3OlA5Lz5{OEm4O|YxQDxxYU6=
A549 NVXhcHZPS3m2b4TvfIlkcXS7IHHzd4F6 NIjlXpU4OiCqcoO= MofRR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{BmgHC{ZYPzbY5oKHerbHSgeJlx\SCyNUOgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFQvPjJizszNMi=> MmGxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MEG4NVkoRjJ|NkCxPFE6RC:jPh?=
A549 NHzxXFNEgXSxdH;4bYNqfHliYYPzZZk> NXHjXmJLPzJiaILz NYr1RZZXS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCneIDy[ZN{cW6pIIfpcIQhfHmyZTDwOVMh[W[2ZYKgO|IhcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFQvPjJizszNMi=> NVHQUHE2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NVE4PzBpPkKzOlEyPzdyPD;hQi=>
MCF7 NHTBN4JCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MXK3NkBpenN? MVzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEWuNFEh|ryPLh?= MnSzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzMEG4PVMoRjJ5MUCxPFk{RC:jPh?=
HepG2 MXnDfZRwfG:6aXPpeJkh[XO|YYm= M3jTfVQ5KGi{cx?= MU\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOU4yKM7:TT6= M{Pw[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NEe5O|cxLz5{NUS3PVc4ODxxYU6=
HCT116 NXX0SYdHSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M1fZbFczKGi{cx?= Mn\XRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ2SxNVYh[2WubIOg[ZhxemW|c3nu[{B4cWymIIT5dIUheDV|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC1MlIyKM7:TT6= Mn[zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzMEG4PVMoRjJ5MUCxPFk{RC:jPh?=
UKF-NB-3 M2PS[GN6fG:2b4jpZ4l1gSCjc4PhfS=> MVy5OkBpenN? NVvw[5ZNS3m2b4TvfIlkcXS7IHHnZYlve3RiZH;4c5J2[mmlaX6tdoV{cXO2YX70JIh2dWGwIGXLSk1PSi1|IHPlcIx{KGGodHXyJFk3KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA2NjV4IN88UU4> NYLhfm5tRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC5OFc3OTdpPkKwPVQ4PjF5PD;hQi=>
SJSA1 MkP5SpVv[3Srb36gZZN{[Xl? M2HIcVchcHK| Mlm2RYN1cX[rdImgZZQheDV|IHnuJIh2dWGwIGPKV2EyKGOnbHzzJIF{e2W|c3XkJIF{KGmwZIXjeIlwdiCxZjDwNlEhdVKQQTDlfJBz\XO|aX;uJIFnfGW{IEegbJJ{KGK7IIHSWE1RS1JiYX7hcJl{cXNiaX6gdJJme2WwY3Wgc4YhOTBnIHj1cYFvKHOncoXtMEBKSzVyIE2gO{4yKM7:TT6= MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV{NEWyO{c,OjJ3MkS1Nlc9N2F-
HCT116 M1v1R2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUHTU3Z[PDhiaILz MV3Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDIR3QyOTZiY3XscJMhcGG{Yn;ybY5oKHB3MzuvL{Bi\nSncjC0PEBpenNiYomgTI9m[2i|dDCzN|I2QCC|dHHpcolv\yCkYYPl[EBndHWxcnXzZ4Vv[2ViYYPzZZktKEeLNUCgQUA5KM7:TT6= NVzSbpV4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmwPFkzOzBpPkK5NFg6OjNyPD;hQi=>
MCF7 MW\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NYO4NpMxPzJiaILz M4GzWGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB5MjDodpMh[nliQ1PLPEBie3OjeTygTWM2OCB;IEiuOUDPxE1w MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB2NU[yNUc,OzByNEW2NlE9N2F-
HCT116 NE\nb4lCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NV2zW3pkOjRiaILz NYrQXY9{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIR3QyOTZicEWzL{8sKGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFI1KGi{czDifUBG\FVxSH;lZ4h{fCB|M{O0NkB{fGGrbnnu[{1j[XOnZDDmcJVwemW|Y3XuZ4Uh[W6jbInzbZMtKEeLNUCgQUA6KM7:TT6= NEDPWpg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[5NVE2Pid-Mkm2PVEyPTZ:L3G+
HCT116 NF7Ud4ZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MoTOO|IhcHK| M{PBUWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFPUNVE3KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDDR2s5KGG|c3H5MEBKSzVyIE2gPU4xPyEQvF2u M1LRUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMES1OlIyLz5|MEC0OVYzOTxxYU6=
A549 NGTZcJpCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NFTFW4k4OiCqcoO= M1TXUmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDh[pRmeiB5MjDodpMh[nliQ1PLPEBie3OjeTygTWM2OCB;IEmuOVgh|ryPLh?= M4i4TlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMES1OlIyLz5|MEC0OVYzOTxxYU6=
HepG2 M3TYc2N6fG:2b4jpZ4l1gSCjc4PhfS=> NXSwR21oOjRiaILz MknMR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFExNjJizszNMi=> NUDtS|dbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4NFI4OTZpPkKzPFAzPzF4PD;hQi=>
NCI-H1299 MnXKRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M{jFflczKGi{cx?= NWnlO241SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBxPTNiLT:tJIh2dWGwIF7DTU1JOTJ7OTDj[YxteyCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBOXFNiYYPzZZktKEmFNUCgQUAyOC52IN88UU4> NVTsb2NzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNlE6OzVpPkOwNlIyQTN3PD;hQi=>
MCF7 MYfDfZRwfG:6aXPpeJkh[XO|YYm= M4PFWFQ5KGi{cx?= MojMR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVEvPiEQvF2u MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZzOEW5OUc,OjV4MUi1PVU9N2F-
Saos2 NUnXUVZ{SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M124OlczKGi{cx?= Ml7pRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCyNUOt[IVncWOrZX70JHNid3N{IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyOi5zIN88UU4> MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl2MEewOEc,OjJ7NEC3NFQ9N2F-
HCT116 NXfTXJU5S3m2b4TvfIlkcXS7IHHzd4F6 NXGxNW4{PzJiaILz M{H1[WN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJJA2OyCneIDy[ZN{cW6pIFjDWFEyPiClZXzsd{Bi\nSncjC3NkBpenNiYomgd5Vt\m:{aH;kZY1qdmViQjDhd5NigSxiR1m1NEA:KDF|IN88UU4> MlznQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF|MUSxNlgoRjJzM{G0NVI5RC:jPh?=
U2OS MXvBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MXu3NkBpenN? MmHmRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCXMl;TJINmdGy|IHX4dJJme3Orbnege4lt\CC2eYDlJJA2OyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTRwM{Gg{txONg>? NYDheHNwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwOFYzPDhpPkKzNFQ3OjR6PD;hQi=>
H1299 MVHDfZRwfG:6aXPpeJkh[XO|YYm= NYWzOGNnPzJiaILz NVHOOnpiS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUDF{OUmgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmekeubzDseYNq\mW{YYPlMYJie2WmIHHzd4F6NCCLQ{WwJF0hOTRwNzFOwG0v NW\3UWhxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSxN|k5PDVpPkK0NVM6QDR3PD;hQi=>
A549 MlPTRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M2S5VFczKGi{cx?= M{Hz[GFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDlfJBz\XO|aX7nJJdqdGRidInw[UBxPTNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF3IN88UU4> NGTG[FA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mkm0NFcxPCd-MkK5OFA4ODR:L3G+
A549 NU\2Vpg4SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NEjvT4o4OiCqcoO= NUTu[Xg{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIV5eHKnc4Ppcochf2muZDD0fZBmKHB3MzDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUWuNVIh|ryPLh?= M1LSXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MES2NlQ5Lz5{M{C0OlI1QDxxYU6=
U937 Ml[5R5l1d3SxeHnjbZR6KGG|c3H5 NVPLRm9sOjRiaILz MofmR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWVk{PyClZXzsd{Bi\nSncjCyOEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVUvPiEQvF2u MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzhyMkexOkc,OjN6MEK3NVY9N2F-
Saos2 NU\BPVRrS3m2b4TvfIlkcXS7IHHzd4F6 MYi3NkBpenN? MlTFR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV4FwezJiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JJN2dG[xcnjv[IFucW6nIFKgZZN{[XluIFfJOVAhRSBzODFOwG0v MmjTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF|MUSxNlgoRjJzM{G0NVI5RC:jPh?=
U2OS MXfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MYe3NkBpenN? MmLORY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCXMl;TJINmdGy|IHX4dJJme3Orbnege4lt\CC2eYDlJJA2OyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTlwNjFOwG0v NXfVV4JFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK5OFA4ODRpPkKyPVQxPzB2PD;hQi=>
NCI-H1299 MWTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NFWxV5o4OiCqcoO= M{LUb2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWgyOjl7IHPlcIx{KGGodHXyJFczKGi{czDifUBES0t6IHHzd4F6NCCLQ{WwJF0hOTlwN{[g{txONg>? NXjYN5o2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwOFU3OjFpPkOwNFQ2PjJzPD;hQi=>
PC3 NHK1W|BEgXSxdH;4bYNqfHliYYPzZZk> M3\DW|czKGi{cx?= MVXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDwOVMudnWubDDQR|Mh[2WubIOgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFIxNjB2IN88UU4> M4fmT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkCxPFE6Lz5{M{[wNVgyQTxxYU6=
PC3 M2T4WWN6fG:2b4jpZ4l1gSCjc4PhfS=> NXjqRnppPzJiaILz M{nRfmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJJA2OyCmZX\pZ4lmdnRiUFOzJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCVUlKgZZN{[XluIFnDOVAhRSB{MD6wOEDPxE1w MorxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MUG3O|AoRjJ|NkGxO|cxRC:jPh?=
A2780/CP70 MX3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYXxeplOT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hSTJ5OECvR3A4OCClZXzsd{BmgHC{ZYPzbY5oKGm|b3flcolk[WyueTDwZYlz\WRicEWzJI12fGGwdDDifUBUWkJiYYPzZZktKEeLNUCgQUAzOC52IN88UU4> MmLBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6N{W4NFEoRjJzOEe1PFAyRC:jPh?=
NCI-H1299 NETZUpNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MXy3NkBpenN? NHHXWWRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIIC1N{1l\W[rY3nlcpQhVkOLLVixNlk6KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyNE41KM7:TT6= NWnWUIxPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK5OFA4ODRpPkKyPVQxPzB2PD;hQi=>
NCI-H1299 NF63ZZNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NVPLUVNjPzJiaILz MojCRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDwOVMh\GWoaXPp[Y51KGi3bXHuJG5EUS2KMUK5PUBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkCuOFgh|ryPLh?= MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB2NkK0PEc,OjNyNE[yOFg9N2F-
HCT116 MlezRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M{i3dFczKGi{cx?= M2\kcGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5icEWzMY52dGxiSFPUNVE3KGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzOS53IN88UU4> NW\vTFJ{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexNFE5QTNpPkK3NVAyQDl|PD;hQi=>
SJSA1 Ml6xR5l1d3SxeHnjbZR6KGG|c3H5 NF\KbFIzPCCqcoO= NULo[XFNS3m2b4TvfIlkcXS7IHnuJIh2dWGwIGPKV2EyKGOnbHzzJI93\XJiZYjwdoV{e2mwZzDoeY1idiCGTUKgZYZ1\XJiMkSgbJJ{KGK7IFPlcIxVcXSncj3HcI8h[XO|YYmsJGVEPTBiPTCyNk45KM7:TT6= NVvOUpRGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmxOVAxPzdpPkK5NVUxODd5PD;hQi=>
C643 NYjrb3BmS3m2b4TvfIlkcXS7IHHzd4F6 MYeyOEBpenN? MYjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDOlQ{KGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyN{DPxE1w NYnme3VoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4NFI4OTZpPkKzPFAzPzF4PD;hQi=>
MDA-MB-231 MVfDfZRwfG:6aXPpeJkh[XO|YYm= MXy0PEBpenN? NXPIOXdOS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVI{OSClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlMvPSEQvF2u NFH2WYQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[xPFU6PSd-MkW2NVg2QTV:L3G+
U2OS Mn;qRY51cXS3bX;yJIF{e2G7 NV\0dXIzPzJiaILz NUfUPYJRSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gWVJQWyClZXzsd{BmgHC{ZYPzbY5oKHerbHSgeJlx\SCyNUOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEK0MlYyKM7:TT6= M3rCZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOUm2OFY2Lz5{MUm5OlQ3PTxxYU6=
HCT116 NFHJTYRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHPvTmNIem:5dHigbY5pcWKrdHnvckBw\iCyNUOg[IVncWOrZX70JIh2dWGwIFjDWFEyPiClZXzsd{BmgHC{ZYPzbY5oKE2GTUKgZpkhW1KEIHHzd4F6NCCJSUWwJF0hOjVwNjFOwG0v MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTh5NUiwNUc,OjF6N{W4NFE9N2F-
HCT116 MXvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUK0PEBpenN? Mm\YS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gdFU{KGuwb3Pr[I94diCKQ2SxNVYh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IFjv[YNpe3RiM{OyOVghe3SjaX7pcoch[mG|ZXSg[ox2d3Knc3PlcoNmKGG|c3H5MEBIUTVyIE2gNlch|ryPLh?= M4TnfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MEi5NlMxLz5{OUC4PVI{ODxxYU6=
Calu NUi0[JJTS3m2b4TvfIlkcXS7IHHzd4F6 M1rJPVI1KGi{cx?= NGP0WGVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBE[Wy3IHPlcIx{KGGodHXyJFI1KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzPy5{IN88UU4> MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzhyMkexOkc,OjN6MEK3NVY9N2F-
HCT116 MmrkRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M1W4fFI1KGi{cx?= MX3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEGxOkBxPTNvLz2gZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiMkSgbJJ{KGK7IFXkWU9Jd2WlaIP0JFM{OzR{IIP0ZYlvcW6pLXLhd4VlKG[udX;y[ZNk\W6lZTDhcoFtgXOrczygS2k2OCB;IEK5JO69VS5? MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ7MUG1Okc,Ojl4OUGxOVY9N2F-
MDA-MB-435S MV7BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M1\HblczKGi{cx?= MmnXRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRFGtUWIuPDN3UzDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkmuOkDPxE1w NIiwNpM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{GwNVg6Oyd-MkexNFE5QTN:L3G+
PC3 M2HqXWN6fG:2b4jpZ4l1gSCjc4PhfS=> M4fF[VI1KGi{cx?= MnrTR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGM{KGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzNE4{KM7:TT6= M3TGcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OECyO|E3Lz5{M{iwNlcyPjxxYU6=
Saos2 MmXlRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MVO3NkBpenN? MVTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IIC1N{Bl\W[rY3nlcpQhcHWvYX6gV4FwezJiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFMyNjZ{IN88UU4> MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB2NkK0PEc,OjNyNE[yOFg9N2F-
HCT116 MmnRRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NH3NTGI1QCCqcoO= NHzXXINCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFEyPiClZXzsd{BmgHC{ZYPzbY5oKHerbHSgeJlx\SCyNUOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygS2k2OCB;IEOyMlEyKM7:TT6= NGfG[Vk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi1NlI4PSd-MkS4OVIzPzV:L3G+
HCT116 M3vVbWN6fG:2b4jpZ4l1gSCjc4PhfS=> M1jufFczKGi{cx?= NILkXG9EgXSxdH;4bYNqfHliYXfhbY5{fCCyNUOg[IVncWOrZX70JIh2dWGwIFjDWFEyPiClZXzsd{Bi\nSncjC3NkBpenNiYomgd5Vt\m:{aH;kZY1qdmViQjDhd5NigSxiR1m1NEA:KDN2IN88UU4> M3W1Z|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzM{G0NVI5Lz5{MUOxOFEzQDxxYU6=
HCT116 MoX0RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MXSyOEBpenN? M3\YZ2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFPUNVE3KGOnbHzzJIV5eHKnc4PpcocheDV|IHHmeIVzKDJ2IHjyd{BjgSCPVGOgZZN{[XluIFfJOVAhRSB|OT62OUDPxE1w NUTR[Gd{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyOlg4QTVpPkK0NlY5Pzl3PD;hQi=>
A549 NWHve2hQSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NWrMclFOPDhiaILz M1i3WGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDHTVUxKD1iNEeuOVkh|ryPLh?= NGPDfJQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi1NlI4PSd-MkS4OVIzPzV:L3G+
HCT116 M2jxb2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 NFHUSXA4OiCqcoO= MlHXRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgbY4heDV|IDitM{0qKGi3bXHuJGhEXDFzNjDj[YxteyCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBOXFNiYYPzZZktKEmFNUCgQUA1Py56IN88UU4> MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl6N{[wPEc,Ojh7OEe2NFg9N2F-
MCF7 MoflRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NHOzOIk1QCCqcoO= MWjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiR1m1NEA:KDR6Lke0JO69VS5? M2[5VVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEWyNlc2Lz5{NEi1NlI4PTxxYU6=
SJSA1 MW\GeY5kfGmxbjDhd5NigQ>? MYKxNEB2VQ>? NUDvdWY1UW6qaXLpeIlwdiCxZjDNSG0zNXB3MzDpcpRmemGldHnvckBqdiCqdX3hckBUUlODMTDj[YxteyCjc4Pld5Nm\CCjczDwOVMh[WO2aY\heIlwdiCjdDCxNEB2VSCkeTDX[ZN1\XKwIHLsc5Q> Mkj4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7Mki5NlIoRjF7OUK4PVIzRC:jPh?=
MCF7 NEjmXlhE\WyuIHP5Z4xmKGG|c3H5 NHzLWFA1KHWP NYLUUG1EOTRiZHH5dy=> NEXqfppKdmS3Y4Tpc44hd2ZiY3XscEBkgWOuZTDhdpJme3RiaX6gbJVu[W5iTVPGO{Bk\WyuczD0doFve2[nY4Tl[EB4cXSqIIC1N{11[XKpZYTpcochcVKQQT3iZZNm\CC|aGLORUBifCB2IIXNJIFnfGW{IEG0JIRigXNiYomgRpJlXSCrbnPvdpBwemG2aX;uJIF{e2G7 MmOyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ2N{SzPFEoRjF4NEe0N|gyRC:jPh?=
MCF7 MULD[YxtKGO7Y3zlJIF{e2G7 NUnZb5F5PCC3TR?= MUOxOEBl[Xm| M1rvZmlv\HWldHnvckBw\iClZXzsJIN6[2ynIHHydoV{fCCrbjDoeY1idiCPQ1[3JINmdGy|IITyZY5{\mWldHXkJIhvWk6SSz30ZZJo\XSrbnegbXJPSS2kYYPl[EB{cFKQQTDheEA1KHWPIHHmeIVzKDF2IHThfZMh[nliQoLkWUBqdmOxcoDvdoF1cW:wIHHzd4F6 NV7yenVHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[0O|Q{QDFpPkG2OFc1OzhzPD;hQi=>
MCF7 MVvBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MlHrOEB2VQ>? MVOxOEBl[Xm| MV3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYYSgOEB2VSCjZoTldkAyPCCmYYnzJIJ6KGOxb33hd5Nq\SC|dHHpcolv\w>? M1XwTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NEe0N|gyLz5zNkS3OFM5OTxxYU6=
MCF7 M33KfWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MkDvOEB2VQ>? NYXydVh5OTRiZHH5dy=> NGPmT|dCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZZN{\XO|ZXSgZZMh[XCyZXHyZY5k\SCxZjDmcIF1fGWwZXSgdIhmdm:2eYDlJIF1KDRidV2gZYZ1\XJiMUSg[IF6eyCkeTDjc49u[XO|aXWgd5RicW6rbne= Mnu0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ2N{SzPFEoRjF4NEe0N|gyRC:jPh?=
MCF7 NIHLWHhHfW6ldHnvckBie3OjeR?= M{ezOmlv\HWldHnvckBw\iCyNUOg[ZhxemW|c3nvckBqdiCqdX3hckBOS0Z5IHPlcIx{KHS{YX7z[oVkfGWmIIfpeIghPTOEUEGteIFz\2W2aX7nJIlTVkFvYnHz[YQhe2iUTlGgZpkhX2W|dHXyckBjdG:2IHHuZYx6e2m| MnTaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ2N{SzPFEoRjF4NEe0N|gyRC:jPh?=
MCF7 M4HKPWZ2dmO2aX;uJIF{e2G7 NXnpSXpYUW6mdXP0bY9vKG:oIIC1N{BmgHC{ZYPzbY9vKGmwIHj1cYFvKE2FRkegZ4VtdHNiYomgW4V{fGW{bjDicI91KGGwYXz5d4l{ NYXwWVZERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[0O|Q{QDFpPkG2OFc1OzhzPD;hQi=>
MCF7 M4mwZWZ2dmO2aX;uJIF{e2G7 NUe0UVF[OThiaILz M2jZPGlv\HWldHnvckBw\iCyNUOgZYNkfW23bHH0bY9vKGmwIHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhOThiaILzJIJ6KFenc4Tldo4h[myxdDDhcoFtgXOrczDpckBxemW|ZX7j[UBw\iB{LkWgcW0h[2GoZnXpcoU> M{m2clxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NEe0N|gyLz5zNkS3OFM5OTxxYU6=
BJ MmrCSpVv[3Srb36gZZN{[Xl? NGXjeY4{KHWP M2\DN2lv\HWldHnvckBw\iCyMkHDTXAyKGW6cILld5Nqd25iaX6gbZJz[WSrYYTl[EBpfW2jbjDCTkBk\WyuczDheEA{KHWPIHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>? NWfiUJVURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[0O|Q{QDFpPkG2OFc1OzhzPD;hQi=>
MCF7 M{K0WWNmdGxiY4njcIUh[XO|YYm= M4TCdVQhfU1? MkHtNVQh\GG7cx?= NYG2UJhuUW6mdXP0bY9vKG:oIHPlcIwh[3mlbHWgZZJz\XO2IHnuJIh2dWGwIF3DSlch[2WubIOgeJJidnOoZXP0[YQhf2m2aDC1N2JROS22YYLn[ZRqdmdiaWLORU1j[XOnZDDzbHJPSSCjdDC0JJVOKGGodHXyJFE1KGSjeYOgZpkhSnKmVTDpcoNwenCxcnH0bY9vKGG|c3H5 NIfuc|U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkS3OFM5OSd-MU[0O|Q{QDF:L3G+
BJ MmTDSpVv[3Srb36gZZN{[Xl? M3PjWlMhfU1? NYfKVFM{UW6mdXP0bY9vKG:oIICyNUBmgHC{ZYPzbY9vKGmwIHnydoFlcWG2ZXSgbJVu[W5iQlqgZ4VtdHNiYYSgN{B2VSCkeTDX[ZN1\XKwIHLsc5Qh[W6jbInzbZM> MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjR5NEO4NUc,OTZ2N{SzPFE9N2F-
SNJSA1 MYHGeY5kfGmxbjDhd5NigQ>? MnHWNUB1dyBzMDD1US=> MWW2JIhzew>? NELkS|BKdmirYnn0bY9vKG:oIF3kcVIhNXB3MzDwdo91\WmwIHnueIVz[WO2aX;uJIlvKGi3bXHuJHNPUlODMTDj[YxteyCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4YheDJzIIDyc5RmcW5iYYSgNUB1dyBzMDD1UUBi\nSncjC2JIhzeyCkeTDX[ZN1\XKwIHLsc5Qh[W6jbInzbZM> NH7Tc4M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUOxOFEzQCd-MkGzNVQyOjh:L3G+
SNJSA1 MnvSSpVv[3Srb36gZZN{[Xl? M3rIfVEhfG9iMUCgeW0> MVG2JIhzew>? MmTpTY5pcWKrdHnvckBw\iCPZH2yJE1xPTNicILveIVqdiCrboTldoFkfGmxbjDpckBpfW2jbjDTUmpUSTFiY3XscJMh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJJA2OyCycn;0[YlvKGG2IEGgeI8hOTBidV2gZYZ1\XJiNjDodpMh[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz MmTiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF|MUSxNlgoRjJzM{G0NVI5RC:jPh?=
SNJSA1 NF7qTHpHfW6ldHnvckBie3OjeR?= MnnMNUB1dyBzMDD1US=> MmTMOkBpenN? NVHZNphbUW6qaXLpeIlwdiCxZjDN[I0zKC2yNUOgdJJwfGWrbjDpcpRmemGldHnvckBqdiCqdX3hckBUVkqVQUGgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5lfWO2aX;uJI9nKE2GTUKgdJJwfGWrbjDheEAyKHSxIEGwJJVOKGGodHXyJFYhcHK|IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>? MnrwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF|MUSxNlgoRjJzM{G0NVI5RC:jPh?=
MCF7 M{XWU2Z2dmO2aX;uJIF{e2G7 M2X5NlI1KGi{cx?= NX:wdoEyXXC{ZXf1cIF1cW:wIH;mJJA2OyCrbjDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCZZYP0[ZJvKGKub4SgZY5idHm|aYO= MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzMEWwNkc,OjdyMUC1NFI9N2F-
MCF7 NGTjcFJHfW6ldHnvckBie3OjeR?= NI\ZSpUzPCCqcoO= NUTvOnhpXXC{ZXf1cIF1cW:wIH;mJG1ldTJiaX6gbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB{NDDodpMh[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz MlzXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUC1NFIoRjJ5MEGwOVAzRC:jPh?=
MCF7 MoPySpVv[3Srb36gZZN{[Xl? NVmzVVJMOjRiaILz NYjrenVlUW6lcnXhd4UhcW5icEWzJIV5eHKnc4Ppc44hcW5iaIXtZY4hVUOINzDj[YxteyCwdXPs[Ykh[W[2ZYKgNlQhcHK|IHL5JGRCWElic4ThbY5qdmdiYnHz[YQhcW2vdX7v[ox2d3Knc3PlcoNmKG2rY4Lvd4NweHl? M{fiWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEGwOVAzLz5{N{CxNFUxOjxxYU6=
MCF7 Mnz2SpVv[3Srb36gZZN{[Xl? MofVNlQhcHK| NVLmSW5QXXC{ZXf1cIF1cW:wIH;mJJAzOSCrbjDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCZZYP0[ZJvKGKub4SgZY5idHm|aYO= NW\HZppQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVA2ODJpPkK3NFExPTB{PD;hQi=>
HCT116 MYDGeY5kfGmxbjDhd5NigQ>? M173S|UxKHWP Mm\FNlQhcHK| NUHLbVVXUW6qaXLpeIlwdiCxZjDwOVMuVUSPMjCoeY5sdm:5bjDvdolocW5rIHnueIVz[WO2aX;uJIV5eHKnc4Pl[EBqdiCyNUOt[IVncWOrZX70JIh2dWGwIFjDWFEyPiClZXzsd{BifCB3MDD1UUBi\nSncjCyOEBpenNiYomgRolHSy2kYYPl[EBHSUOVIH\sc5ch[3m2b33leJJq[yCjbnHsfZNqew>? MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDJ4OEe5OUc,OjR{Nki3PVU9N2F-
U2OS MlOySpVv[3Srb36gZZN{[Xl? MmHWNk42KHWP M4i1WVEzKGi{cx?= NI\0Zm1UfGGkaXzpfoF1cW:wIH;mJJA2OyCrbjDoeY1idiCXMl;TJINmdGy|IHHzd4V{e2WmIHHzJIlvfHKjY3XscJVt[XJicEWzJIxmfmWuIHH0JFIvPSC3TTDh[pRmeiBzMjDodpMh[nliV3XzeIVzdiCkbH;0eIlv\w>? NI[3WoI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkK4PFY5PCd-Mk[yPFg3QDR:L3G+
HCT116 M1y3RmZ2dmO2aX;uJIF{e2G7 MYqxNEB2VQ>? NVLQW5Y1OjBiaILz NYLPRY5MUW6qaXLpeIlwdiCxZjDWNU1xPTNxTVTNNk1XOiBqdX7rco94diCxcnnnbY4qKGmwdHXyZYN1cW:wIHX4dJJme3OnZDDpckBpfW2jbjDIR3QyOTZicEWzMU8uKGOnbHzzJIF1KDFyIIXNJIFnfGW{IEKwJIhzeyCkeTDibY9ud2ynY4XsZZIh\my3b4Lld4NmdmOnIHPvcZBt\W2nboTheIlwdi2kYYPl[EBndG:5IHP5eI9u\XS{aXOgZY5idHm|aYO= Mmi2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh6MEC0OVUoRjJ6OECwOFU2RC:jPh?=
IMR32 NWrKTlVyTnWwY4Tpc44h[XO|YYm= NHSxVpYzPCCqcoO= NV3LWmtOUW6lcnXhd4UhcW5icEWzJIV5eHKnc4Ppc44hcW5iaIXtZY4hUU2UM{KgZ4VtdHNiboXjcIVqKGGodHXyJFI1KGi{czDifUBFSVCLIIP0ZYlvcW6pIHLhd4VlKGmvbYXuc4ZtfW:{ZYPj[Y5k\SCvaXPyc5Nkd3C7 MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzMEWwNkc,OjdyMUC1NFI9N2F-
MCF7 NV3JOW5YTnWwY4Tpc44h[XO|YYm= NUezRnpkOTBidV2= NYrqTJFXOTZiaILz NVu5UYNLUW6qaXLpeIlwdiCxZjDNSG0zNXB3MzDpcpRmemGldHnvckBqdiCqdX3hckBOS0Z5IHPlcIx{KGG|c3Xzd4VlKGG|IILleoVze2GuIH;mJG1FVTJvZHXw[Y5l\W62IHnubIljcXSrb36gc4YheDV|LXnu[JVk\WRidILhcpNkemmydHnvcoFtKGGldHn2bZR6KGG2IEGwJJVOKGGodHXyJFE3KGi{czDifUBlfWGuLXz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfS=> NHvzZlE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{W0NFk{PCd-MkO1OFA6OzR:L3G+
MCF7 MmHVRZBweHSxc3nzJIF{e2G7 NXPT[2p7OyC3TR?= Mmn2NlQhfG9iN{KgbJJ{ MXfJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKE2FRkegZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKEKlbD34UEBmgHC{ZYPzbY9vKGyndnXsJIF1KDNidV2gZYZ1\XJiMkSgeI8hPzJiaILzJIJ6KFenc4Tldo4h[myxdITpcoch[W6jbInzbZM> NX\WT5lpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4NFI4OTZpPkKzPFAzPzF4PD;hQi=>
MCF7 NIDyb2NCeG:ydH;zbZMh[XO|YYm= Mmj1N{B2VQ>? NGnnO4kzPCC2bzC3NkBpenN? M{fDOmlv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iTVPGO{Bk\WyuczDhd5Nme3OnZDDhd{Bm[XKueTDhdI9xfG:2aXOgZ4VtdHNiYYSgN{B2VSCjZoTldkAzPCC2bzC3NkBpenNiYomgZY5v\XirbjDWMWZKXENxcILvdIllcXWvIHnv[Ill\SC|dHHpcolv\yCkYYPl[EBHSUOVIH\sc5ch[3m2b33leJJ6KCiUdnKgQUA1KCVr NIGyfmo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{iwNlcyPid-MkO4NFI4OTZ:L3G+
MCF7 M{DIdWFxd3C2b4Ppd{Bie3OjeR?= M2fmPFMhfU1? MoK3NlQhfG9iN{KgbJJ{ MYrJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKE2FRkegZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4heDJzIHX4dJJme3Orb36gcIV3\WxiYYSgN{B2VSCjZoTldkAzPCC2bzC3NkBpenNiYomgW4V{fGW{bjDicI91fGmwZzDhcoFtgXOrcx?= NXjYUmFiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4NFI4OTZpPkKzPFAzPzF4PD;hQi=>
MCF7 NXXPVlJRSXCxcITvd4l{KGG|c3H5 NEPCeY8{KHWP MYCyOEB1dyB5MjDodpM> M1L0bmlv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iTVPGO{Bk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCEY3ytfHMh\XiycnXzd4lwdiCuZY\lcEBifCB|IIXNJIFnfGW{IEK0JJRwKDd{IHjyd{BjgSCZZYP0[ZJvKGKub4T0bY5oKGGwYXz5d4l{ M1;CZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OECyO|E3Lz5{M{iwNlcyPjxxYU6=
MCF7 MljBRZBweHSxc3nzJIF{e2G7 Mn7zOVAhdk1? MYWyOEB1dyB5MjDodpM> MYLJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKE2FRkegZ4VtdHNiYYPz[ZN{\WRiYYOgZYNkfW23bHH0bY9vKG:oIHPhd5Bie2VvMzDjcIVifmGpZTDwdo9lfWO2IHH0JFUxKG6PIHHmeIVzKDJ2IITvJFczKGi{czDifUBY\XO2ZYLuJIJtd3S2aX7nJIFv[Wy7c3nz NETR[3A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{iwNlcyPid-MkO4NFI4OTZ:L3G+
MCF7 NXLZSJhZS2WubDDjfYNt\SCjc4PhfS=> M4LTdlMhfU1? MnTLNlQhfG9iN{KgbJJ{ M3nST2NmdGxiY4njcIUh[XK{ZYP0JIlvKGi3bXHuJG1ETjdiY3XscJMh[XO|ZYPz[YQh[XNiYXPjeY12dGG2aX;uJIF1KEdyL1exJJBp[XOnIHH0JFMhfU1iYX\0[ZIhOjRidH:gO|IhcHK|IHL5JJBzd3CrZHn1cUBqd2SrZHWgd5RicW6rbnetZoF{\WRiRlHDV{BidmGueYPpdy=> MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzhyMkexOkc,OjN6MEK3NVY9N2F-

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p53 / MDM2 / p21 / Bax / Bak / Noxa / cleaved caspase / pro-caspase; 

PubMed: 16014563     


Expression of apoptosis- and cell-cycle–associated proteins in OCI-AML-3 cells, which were treated with 5 μM Nutlin-3a for the indicated times. Nutlin-3a induced increased protein expression of p53, MDM2, and p21 in OCI-AML-3 cells in a time-dependent fashion. Nutlin-3a induced Noxa, a BH3-only member of the Bcl-2 family, followed by caspase activation. β-actin was used to confirm equal loading of proteins. Arrowheads indicate cleared caspases.

BMI-1; 

PubMed: 26887044     


Western blot analysis of BMI-1 and actin was performed in BV-173, SUP-B15, NALM-6, NALM-19 and REH cell lines after 24 hours treatment with increasing concentrations of Nutlin-3a (1 μM, 2 μM, 5 μM) and with DMSO control. 

p53-Ser15 / p53-Ser37 / p53-Lys382 / MDM2 / CDC2 / PLK1 / HSC70; 

PubMed: 23666059     


Expression of the indicated proteins in whole-cell lysates of cells treated for 96 h with 50 μM resveratrol (R), 5 μM nutlin-3a (N), or co-treated with both substances (RN).

16014563 26887044 23666059
Immunofluorescence
p-p21 / β-actin; 

PubMed: 31083332     


Cells were treated with fluoride (5 mM) with/without Nutlin-3a for 24 h. p-p21 (green), nucleus (DAPI; blue) and β-actin (red) expression were detected by immunocytochemistry. Nutlin-3a addition augmented p-p21 expression compared to NaF treatment alone.

P53; 

PubMed: 21394100     


At 12 h following treatment with nutlin-3a, DoHH2 and MCA cells had increased levels of p53 visualized by immunofluorescence. p53 localization was predominantly nuclear. The 4',6-diamidino-2-phenylindole was used as counterstain of the nuclei.

Ac-p300; 

PubMed: 30240745     


HepG2 cells were treated with 5 μM Nutlin-3a for 24 hr, and the levels of Ac-p300 and p53 were assessed by co-immunofluorescence. Fluorescence intensity of Ac-p300 in control cells versus Nutlin-3a-treated cells have been quantified (represented as mean ± SD, unpaired two-tailed Student's t test, n = 50 of three independent experiments). Scale bar, 10 μm.

31083332 21394100 30240745
Growth inhibition assay
Cell viability; 

PubMed: 26248031     


All 15 cell lines were plated in 96-well plates. After 24h, media was exchanged and cells were treated with incremental concentrations of Nutlin-3a (1 μM, 5 μM, 10 μM, 25 μM, 50 μM, and 70 μM). After 72h of Nutlin-3a treatment, cell viability was measured by WST assay and compared to untreated control.

26248031
体内研究 Nutlin-3α以剂量依赖性方式抑制异种移植物生长,在最高剂量(200毫克/千克)时表现大量的肿瘤收缩。Nutlin-3是p53途径在体内的选择性活化剂,并高度有效地抗SJSA-1骨肉瘤。有野生型p53和MDM2基因扩增的肿瘤对Nutlin-3α治疗应答最好。 [1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[3]
- 合并

Biacore研究:

竞争分析是在Biacore S51进行。甲系列S传感器芯片CM5衍生化用于固定一个PentaHis抗体来捕获His-标记的p53。捕获的水平是〜200响应单位(1单位响应对应于每毫米21 pg的蛋白质)。 MDM2蛋白的浓度被保持恒定在300 nM。将试验化合物溶解于10 mM DMSO中,并进一步稀释使每个MDM2测试样品中的浓度系列抑制剂。该试验是在25¡交流的电泳缓冲液(10 mM HEPES,0.15M的NaCl,2%DMSO)中运行。 MDM2-p53在抑制剂存在下的结合的计算方法是在没有抑制剂的结合的百分比,IC 50是使用微软EXCE计算。
细胞实验:[2]
- 合并
  • Cell lines: OSA, T778, RMS13, U2OS, SaOS-2
  • Concentrations: ~5 μM
  • Incubation Time: 120小时
  • Method: SRB
    (Only for Reference)
动物实验:[1]
- 合并
  • Animal Models: SJSA-1移植体
  • Dosages: 50, 100, 200 毫克/千克 每天两次
  • Administration: 口服
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 100 mg/mL (171.97 mM)
Water Insoluble
Ethanol '100 mg/mL
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5% DMSO+55% PEG 300+ddH2O
8mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 581.49
化学式

C30H30Cl2N4O4

CAS号 675576-98-4
储存条件 粉状
溶于溶剂
别名 (-)-Nutlin-3

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    What is the difference between S1061 (Nutlin-3) and S8059 (Nutlin-3a)?

  • 回答:

    S1061 is a racemic mixture of Nutlin3a and Nutlin3b. s8059 is the active enantiomer of Nutlin3.

Mdm2 Signaling Pathway Map

相关Mdm2产品

Tags: 购买Nutlin-3a | Nutlin-3a供应商 | 采购Nutlin-3a | Nutlin-3a价格 | Nutlin-3a生产 | 订购Nutlin-3a | Nutlin-3a代理商
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID