Rucaparib (AG-014699,PF-01367338) phosphate

目录号:S1098

Rucaparib (AG-014699,PF-01367338) phosphate Chemical Structure

Molecular Weight(MW): 421.36

Rucaparib (AG-014699,PF-01367338)是一种PARP抑制剂,无细胞试验中作用于PARP1的Ki为1.4 nM,对其余8个PARP位点也有结合亲和力。Phase 3。

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客户使用Selleck该产品发表文献17篇:

客户使用该产品的8个实验数据:

  • Representative images for RAD51 and γH2AX foci formation, surrogate DSB markers, in stable shK-H or shSCR 231 cells after rucaparib or vehicle (0.01% DMSO) treatment for 24 hours. DAPI-stained cell nuclei. Scale bars, 10 μm.

    Clin Cancer Res, 2018, doi:10.1158/1078-0432.CCR-17-1118. Rucaparib (AG-014699,PF-01367338) phosphate purchased from Selleck.

    MDA-MB-231 cells were inoculated into mammary fad pad of nude mice, and the mice with established tumors were treated with olaparib or rucaparib. Tumors were then isolated to evaluate PD-L1 expression by IHC staining (C). Black arrowheads indicate the detected PD-L1 signals. Scale bar, 50 μm.

    Clin Cancer Res, 2017, 23(14):3711-3720. Rucaparib (AG-014699,PF-01367338) phosphate purchased from Selleck.

  • For anchorage dependent clonogenic assays, HER2+ breast cancer BT474 cells were seeded at low density in 6-well plates and allowed to adhere overnight. The next day, olaparib and rucaparib were added at the indicated concentrations. Media and drugs were replenished every three days. After 10-15 days, depending on cell proliferation rate, cells were fixed and stained with crystal violet. Images and graphs indicate the results compared to control condition. Data are mean ± S.D. n.s.: non-significant, ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.

    Eur J Cancer 2014 50(15), 2725-34. Rucaparib (AG-014699,PF-01367338) phosphate purchased from Selleck.

    Total cell extracts of BT-474 cells treated with increasing concentrations of olaparib or rucaparib were subjected to western blot analysis for PARP-1 and poly ADP-ribose (PAR) expression. β-tubulin was used as loading control. Representative images from two separate experiments are shown.

    Eur J Cancer 2014 50(15), 2725-34. Rucaparib (AG-014699,PF-01367338) phosphate purchased from Selleck.

  • Three sensitive and three resistant cell lines were treated for 24 h with 0.02% DMSO (negative control) or 10 uM rucaparib. Serving as positive control were cells fixed 30 min after exposure to 2 Gy IR. Image acquisition was performed with a confocal microscope (Leica TCS SP2) using the 100X objective and a 2X optical zoom and oil immersion. Red: γH2AX foci. Green: RAD51 foci. *P < 0.05 **P < 0.01 ***P < 0.001. Fluorescence microscopy images of DAPI-stained rucaparib-sensitive (HN4) and rucaparib-resistant (SAS) HNC cell lines treated with DMSO, 2 Gy or 10 uM rucaparib for 24 h.

    Oral Oncol 2014 50(9), 825-31. Rucaparib (AG-014699,PF-01367338) phosphate purchased from Selleck.

    purified PARP-1 and His-XPA were incubated alone ( lane 7 ), with activated PARP-1 (addition of activated DNA and NAD+, lane 8 ), or in the presence of the PARP inhibitor AG-014699 (lane 9 ). Following the various treatments, His-XPA was pulled down ( IP ) from each sample using cobalt-conjugated magnetic beads.

    J Biol Chem 2012 287, 39824-33. Rucaparib (AG-014699,PF-01367338) phosphate purchased from Selleck.

  • Antitumor effects of transfecting of INPP4B gene combined with PARP inhibitor treatment on PC3 cells. (A) The change of cell number and shape under the microscope. (B) The viability of PC3 cells measured using CCK-8. (C) The cell cycle phase distribution of PC3 detected by flow cytometry. (D) Apoptosis of PC3 cells detected using annexin V-FITC/PI staining. (Asterisks denote statistical significance between Lenti-INPP4B+PARP inhibitor and Lenti-INPP4B and PARP inhibitor treatment, *P<0.05).

    Urol Oncol 2014 32(5), 720-6. Rucaparib (AG-014699,PF-01367338) phosphate purchased from Selleck.

    in vivo suppression of PAR formation by the PARP inhibitor AG-014699 upon induction of DNA damage

    Primary human lung fibroblast cells (MRC-5) were pre-treated with the indicated concentration of the PARP inhibitor AG-014699 for two hours. Oxidative DNA damage was induced by 500 µM H2O2 for 10 min and cellular PARP activity was measured by immuno-staining of poly(ADP)-ribose (PAR) (right panels). The in vivo effect of PARP inhibition was compared to cells without DNA damage induction and inhibitor (control) and H2O2-treated cells without inhibitor.
    Average nuclear PAR staining intensities of more than 50 cells were statistically analysed by Kruskal-Wallis and the post-hoc Dunn’s Multiple Comparison tests (left panel). Asterisks indicate highly significant (p<1%) differences to H2O2-treated cells without PARP inhibitor. Thick horizontal bars mark medians and error bars the interquartile range.
     
     

     

    Dr. David Schrmann from University of Base. Rucaparib (AG-014699,PF-01367338) phosphate purchased from Selleck.

产品安全说明书

PARP抑制剂选择性比较

生物活性

产品描述 Rucaparib (AG-014699,PF-01367338)是一种PARP抑制剂,无细胞试验中作用于PARP1的Ki为1.4 nM,对其余8个PARP位点也有结合亲和力。Phase 3。
特性 AG-014699是第一个用于人类癌症疗法的PARP 抑制剂。
靶点
PARP [1]
(Cell-free assay)
1.4 nM(Ki)
体外研究

AG-014699有效抑制纯化的全长人类PARP-1,作用于LoVo和SW620细胞显示出强PARP抑制效果。AG-014699是AG14447的磷酸盐形式,且是第一个和temozolomide联用用于临床实验的PARP抑制剂。[1] AG-014699的辐射增敏性是由于下游NF-κB激活的抑制,及SSB修复抑制。AG-014699可以作用于DNA损伤激活的NF-κB,且克服传统NF-κB抑制剂的毒性,不会损害其他重要的炎症反应。[2]1μM AG-014699作用于D283Med细胞时抑制PARP-1活性达97.1%。[3]在NB-1691, SH-SY-5Y, 和SKNBE(2c)细胞中AG-014699明显增强Topotecan和Temozolomide的细胞毒性。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
BT-474 NE\kVJNHfW6ldHnvckBCe3OjeR?= M2\OVlAvOS9zL{WwNE8yODByIH7N M4LMcYlvcGmkaYTzJHBCWlBiYXP0bZZqfHliYYSgd5RienSrbnegZ49v[2W{boTyZZRqd25ib3[gOVAxKG6P M1jj[FI2OTJ6NEW1
BT474 NFHYcYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGewN|U2ODBibl2= M1vOPVEx6oDVMUZCpIQ> MnXEdoVlfWOnczDj[YxtKGe{b4f0bEBqdiC2aHWg[o92eiCuaX7ld{BidmRic3nncolncWOjboTsfS=> NGCxPVUzPTF{OES1OS=>
SKBR3 NFPEOo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHHZlJ3PTByIH7N NYPE[pFwOTEkgKOxOeKh\A>? MXTy[YR2[2W|IHPlcIwh\3Kxd4ToJIlvKHSqZTDmc5VzKGyrbnXzJIFv\CC|aXfubYZq[2GwdHz5 Mk\MNlUyOjh2NUW=
AU565 NIizPHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVO1NFAhdk1? NEHYNG4yOOLCk{G1xsBl Mnu0doVlfWOnczDj[YxtKGe{b4f0bEBqdiC2aHWg[o92eiCuaX7ld{BidmRic3nncolncWOjboTsfS=> Mn7SNlUyOjh2NUW=
EFM192A NWHWRpZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvIOVAxKG6P NEnqOFEyOOLCk{G1xsBl MkXzdoVlfWOnczDj[YxtKGe{b4f0bEBqdiC2aHWg[o92eiCuaX7ld{BidmRic3nncolncWOjboTsfS=> NXnHToZKOjVzMki0OVU>
MDA-MB-231 MY\GeY5kfGmxbjDBd5NigQ>? NFK4c3IyOC9{MD:0NEDPxE1? MVWyOEBp MVrpcoNz\WG|ZYOgdE1CU1RibHX2[Yx{KGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz MWqyOFQzODF3Mh?=
MDA-MB-231 NY\SR2x6S2WubDDWbYFjcWyrdImgRZN{[Xl? NWG5c|I{OC5zLUSwJO69VQ>? MXKyOEBp NITib|dKSzVy4pEJQgKBkTF5Lke3xsDPxE1? NV:zb2dqOjR2MkCxOVI>
MDA-MB-231 NX\jUnB1SXCxcITvd4l{KEG|c3H5 NYnp[VhWOTBxMkCvOFAh|ryP NETNc4UzPCCq MmrFbY5lfWOnczDhdI9xfG:|aYOg[I9{\SCmZYDlcoRmdnSueR?= MlWwNlQ1OjBzNUK=
MDA-MB-231 MnfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnJNVAwOjBxNECg{txO MViyOEBp MXzicI9kc3NiY3XscEBkgWOuZTDwdo9oemW|c3nvckBqdiCJMj;NJJBp[XOn MmnyNlQ1OjBzNUK=
H460 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfzWpJ1PDByIH7N NXnMVGNsOjUEoHi= MmHWbY5kemWjc3XzJINmdGy3bHHyJJJi\Gmxc3Xud4l1cX[rdIm= M2LtdVI1PDFzNkGx
A549  M4DSZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\oSVQxOCCwTR?= MX2yOOKhcA>? M{LI[olv[3KnYYPld{Bk\WyudXzhdkBz[WSrb4PlcpNqfGm4aYT5 NF20e2kzPDRzMU[xNS=>
DT40 NHPpd2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTJzIH7N MkfENlQ{PTZ6MUO=
DU145 M3\ZTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\EdGlEPTB;MUigcm0> NH7pfI8zPDN3NkixNy=>
COLO704 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUf3UWgxUUN3ME2yMlUzKMLzIECuOlch|ryP M2i4UFI{PzJ7NECy
OVMANAb MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\N[JpUUUN3ME2yMlU5KMLzIECuN|gh|ryP M4L2VlI{PzJ7NECy
OV177 NG\yUYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLjTWM2OD1{Lke4JOKyKDBwN{Gg{txO NWXkNWsxOjN5Mkm0NFI>
OAW28 NUTheFkzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvETWM2OD1|Lk[xJOKyKDBwMkig{txO NH76Z|AzOzd{OUSwNi=>
OVSAHO M{Tkc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHOTWM2OD1|Lk[0JOKyKDBwM{Og{txO NGHD[Y8zOzd{OUSwNi=>
OVKATE MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPORpVqUUN3ME2zMlY1KMLzIEGuO|kh|ryP NUfvVlhPOjN5Mkm0NFI>
OVCAR3 NXHmSHZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXKTWM2OD1|Lke0JOKyKDBwNECg{txO M{fX[|I{PzJ7NECy
PEO14 M{PHPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfWdXBmUUN3ME2zMlg1KMLzIECuO|Yh|ryP NEX2OpUzOzd{OUSwNi=>
A2780 M1fxcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4K0c2lEPTB;Mz65OEDDuSByLkK1JO69VQ>? NELnNJYzOzd{OUSwNi=>
OVTOKO M4rrOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTnTWM2OD12LkG0JOKyKDFwNUOg{txO MUmyN|czQTRyMh?=
KURAMOCHIb NVnpe4RRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfCTWM2OD12LkO0JOKyKDBwMkmg{txO NGG1T2gzOzd{OUSwNi=>
TOV21G MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvEc4RKSzVyPUWuNFchyrFiMT6zNEDPxE1? NGDTTIgzOzd{OUSwNi=>
OVISE NGixfHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PCbWlEPTB;NT62PEDDuSByLkKzJO69VQ>? M2HscVI{PzJ7NECy
KK MmTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTZwMUWgxtEhOS52MjFOwG0> M3zERVI{PzJ7NECy
RMUGS NViw[I5uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlW4TWM2OD15LkCzJOKyKDFwOEOg{txO MX:yN|czQTRyMh?=
PEO6 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTdwME[gxtEhOC55NDFOwG0> Ml3ZNlM4Ojl2MEK=
OVCA429 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPITHpKSzVyPUiuNlkhyrFiMT62OEDPxE1? NHv5TYwzOzd{OUSwNi=>
OV167 M1vsVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDTS|VXUUN3ME24MlM{KMLzIEGuNVgh|ryP M133TVI{PzJ7NECy
RMG1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHkTWM2OD17LkOyJOKyKDJwM{[g{txO Mn;vNlM4Ojl2MEK=
OVCAR5 NGDHbHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPvdWl6UUN3ME25MlUxKMLzIEKuOVkh|ryP M2HxPFI{PzJ7NECy
EFO21 NYDzOFJvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTlwOUKgxtEhOS56NzFOwG0> NYnxbVR3OjN5Mkm0NFI>
ES2 M4[zV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfjTWM2OD1zMD6xNkDDuSBzLkKzJO69VQ>? Ml3jNlM4Ojl2MEK=
Tyk-nu MoHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{G0WWlEPTB;MUCuNlAhyrFiMT6xNkDPxE1? MX[yN|czQTRyMh?=
CAOV3 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLpTWM2OD1zMD6zO{DDuSByLki3JO69VQ>? MWCyN|czQTRyMh?=
OV207 M1n3PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\ndmlEPTB;MUKuNlchyrFiMD6zNkDPxE1? NWW1fnVwOjN5Mkm0NFI>
HEY NGLFdHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFOxU2dKSzVyPUGzMlAyKMLzIECuO|Uh|ryP NYn2TmhPOjN5Mkm0NFI>
DOV13 NVnyb4VHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7zTWM2OD5zNTFOwG0> NVywT4NLOjN5Mkm0NFI>
EFO27 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnIXHFzUUN3ME6xOUDPxE1? NIfsTIgzOzd{OUSwNi=>
HEY C2 M2Piemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXSTWM2OD5zNTFOwG0> M4TZNFI{PzJ7NECy
KOC-7cc NXHN[3g1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILLRmVKSzVyPkG1JO69VQ>? MWGyN|czQTRyMh?=
MCASb NGPIfnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\RTWM2OD5zNTFOwG0> NEe1PHQzOzd{OUSwNi=>
OAW42 M2C2NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2K3cmlEPTB-MUWg{txO MmDnNlM4Ojl2MEK=
OV2008 M3frVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoH2TWM2OD5zNTFOwG0> M3\JW|I{PzJ7NECy
OV90 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jRUWlEPTB-MUWg{txO MX6yN|czQTRyMh?=
OVCA420b Mn7jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRjF3IN88US=> MYSyN|czQTRyMh?=
OVCA432 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYi4S2JIUUN3ME6xOUDPxE1? M4fpZlI{PzJ7NECy
PEA2 NVroeFR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;4Z2lEPTB-MUWg{txO NGT0UWYzOzd{OUSwNi=>
SKOV3 NFzMOJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7DWFN{UUN3ME6xOUDPxE1? M2HOV|I{PzJ7NECy
TOV112D MmrBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrTfXAxNTNizszN MXfJR|UxRjF3IN88US=> NF\YPHUzOzd{OUSwNi=>
C4-2 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HGUlAuOyEQvF2= M1rzVFE1KGR? MXTEUXNQ NFXHOnVl\WO{ZXHz[ZMh[2:ub375JI52dWKncjDkc5NmKGSncHXu[IVvfGy7 NVTvVXF6OjN3NkWyOFQ>
PC3 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDLdlE6OC1|IN88US=> M1rMelE1KGR? MY\EUXNQ MYXk[YNz\WG|ZYOgZ49td267IH71cYJmeiCmb4PlJIRmeGWwZHXueIx6 MViyN|U3PTJ2NB?=
DU145 NG\GV29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXqwMVMh|ryP NUjsZ3BZOTRiZB?= M4nmU2ROW09? NXfhNWw6\GWlcnXhd4V{KGOxbH;ufUBvfW2kZYKg[I9{\SCmZYDlcoRmdnSueR?= MnTXNlM2PjV{NES=
VCaP  MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XMVlAuOyEQvF2= M13uc|E1KGR? M1;DbWROW09? MmHl[IVkemWjc3XzJINwdG:weTDueY1j\XJiZH;z[UBl\XCnbnTlcpRtgQ>? MY[yN|U3PTJ2NB?=
LNCaP  NX\IXmkxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\wNE0{KM7:TR?= MWKxOEBl MV7EUXNQ M1jSbYRm[3KnYYPld{Bkd2yxbomgcpVu[mW{IHTvd4Uh\GWyZX7k[Y51dHl? NYDGXFA3OjN3NkWyOFQ>
MDA-MB-468 MlnKR4VtdCCYaXHibYxqfHliQYPzZZk> MXfJR|UxRTlwNzFOwG0> NYDFW5ZQOjJ4N{ixOlE>
MDA-MB-231 NX2wU4dQS2WubDDWbYFjcWyrdImgRZN{[Xl? MVzJR|UxRTF|IN88US=> NYTsSnJqOjJ4N{ixOlE>
Cal-51 NWrQVm4{S2WubDDWbYFjcWyrdImgRZN{[Xl? M1LFW2lEPTB;OD62JO69VQ>? MV2yNlY4QDF4MR?=

... Click to View More Cell Line Experimental Data

体内研究 AG-014699无毒,明显增强D384Med移植瘤DNA修复功能蛋白中temozolomide诱导的TGD。药物动力学研究显示在脑组织中也检测到AG-014699,说明AG-014699用于治疗颅内恶性肿瘤具有潜在可能。[3]活体模型(NB1691和SHSY5Y移植瘤)研究显示AG-014699增强temozolomide的抗癌活性,产生彻底且持久的肿瘤衰退现象。[4]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[3]
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激酶实验:

不同浓度(0到1μ)AG-014699作用于5×103D283Med 细胞,与只用DMSO处理5×103D283Med细胞相比,来测定PARP活性抑制率。参考GCLP验证试验的PAR标准曲线,在和NAD+及寡核苷酸(底物和激活剂)温育的6分钟期间,使用10H PAR抗体,通过PAR形成量的免疫检测,在细胞样本中测量最大程度刺激的PARP活性。
细胞实验: [3]
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  • Cell lines: D425Med, D283Med和D384Med细胞
  • Concentrations: 0.4 μM
  • Incubation Time: 3或5天
  • Method: 髓母细胞瘤细胞系包含D425Med, D283Med,和D384Med细胞,分别按1×103, 3×103,和3×103密度接种在96孔板上。接种24小时(D384Med细胞)或48小时(D283Med和D425Med细胞)后,细胞用不同浓度temozolomide处理。培养3天(D425Med和D384Med细胞)或5天(D283Med细胞)后,通过XTT细胞增殖检测试剂盒检测细胞活力。用DMSO处理的对照组和0.4μ AG-014699处理的实验组的百分比表示细胞生长。计算temozolomide单独使用或者和AG-014699联用时的GI50值。Temozolomide单独使用时的GI50值和与AG-014699联用时的GI50值之比就是趋化因子50(PF50)值。
    (Only for Reference)
动物实验:[3]
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  • Animal Models: 携带D283Med移植瘤的CD-1裸鼠
  • Formulation: 盐水溶液
  • Dosages: 1 mg/kg
  • Administration: 腹腔注射,每天1次或4次
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 84 mg/mL (199.35 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
10mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 421.36
化学式

C19H18FN3O.H3PO4

CAS号 459868-92-9
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03694262 Not yet recruiting Endometrial Cancer Medical College of Wisconsin April 1 2019 Phase 2
NCT03694262 Not yet recruiting Endometrial Cancer Medical College of Wisconsin April 1 2019 Phase 2
NCT03840200 Not yet recruiting Breast Cancer|Prostate Cancer|Ovarian Cancer Hoffmann-La Roche March 22 2019 Phase 1|Phase 2
NCT03795272 Not yet recruiting Cervical Cancer Nordic Society for Gynaecologic Oncology|Institute of Cancer Research United Kingdom|Central and Eastern European Oncology Group|North Eastern Germany Society of Gynaecologic Oncology|Belgian Gynaecological Oncology Group|Princess Margaret Hospital Canada|PGOG (Polish Gynaecologic Oncology Group)|GSO Global Clinical Research BV|GCP-enhederne March 1 2019 Phase 2
NCT03639935 Recruiting Biliary Tract Cancer University of Michigan Rogel Cancer Center|Dana-Farber Cancer Institute|Vanderbilt University Medical Center March 2019 Phase 2
NCT03617679 Recruiting Metastatic Endometrial Cancer University of Colorado Denver|Clovis Oncology Inc.|National Cancer Institute (NCI) March 6 2019 Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID