Midostaurin (PKC412)

目录号:S8064 别名: CGP 41251 中文名称:米哚妥林

仅限科研使用

Midostaurin (pkc412, CGP 41251) 是一种多靶点激酶抑制剂,作用于PKCα/β/γSykFlk-1AktPKAc-Kitc-Fgrc-SrcFLT3PDFRβVEGFR1/2IC50为80-500 nM。

Midostaurin (PKC412) Chemical Structure

CAS: 120685-11-2

规格 价格 库存 购买数量
RMB 3030.3 现货
RMB 9582.3 现货
大包装 有超大折扣

今日订购,明日送达 全国免运费 分装免费 分装成小规格产品(单支最小为1mg)
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全国免费电话:400-668-6834   |   Email:info@selleck.cn

客户使用Selleck生产的Midostaurin (PKC412)发表文献33篇:

产品安全说明书

PKC抑制剂选择性比较

相关PKC产品

生物活性

产品描述 Midostaurin (pkc412, CGP 41251) 是一种多靶点激酶抑制剂,作用于PKCα/β/γSykFlk-1AktPKAc-Kitc-Fgrc-SrcFLT3PDFRβVEGFR1/2IC50为80-500 nM。
靶点
PKCα [1]
(Cell-free assay)
PKCγ [1]
(Cell-free assay)
PKCβ1 [1]
(Cell-free assay)
PKCβ2 [1]
(Cell-free assay)
PPK [1]
(Cell-free assay)
点击更多
22 nM 24 nM 30 nM 31 nM 38 nM
体外研究

Midostaurin(pkc412)是一种广谱的蛋白激酶抑制剂。Midostaurin(pkc412)强烈与常规PKC-α, -β 和 -γ, PDGFRβ, VEGF-R2, VEGF-R1,及CDK 1-cyclin B复合物的ATP结合位点相互作用。Midostaurin(pkc412)在相似的亚微摩尔浓度时,在体外抑制多种人类和动物细胞系的生长。Midostaurin(pkc412) 在体外也有效抑制胶质母细胞瘤增殖,且诱导细胞在G2/M期累积,并形成巨核,具有广泛的碎片和凋亡小体。Midostaurin(pkc412)在体外能够逆转肿瘤细胞中p-糖蛋白介导的多药耐药性。[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EOL-1 M1TPWGN6fG:2b4jpZ4l1gSCjc4PhfS=> NUXONVU1PzJiaILz MXvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDFU2wuOSClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRUKGG|c3H5MEBKSzVyIE2gNE4xODN6IN88UU4> M{m3NlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7M{WwPVIxLz5{OUO1NFkzODxxYU6=
MOLM13 M1PTOGN6fG:2b4jpZ4l1gSCjc4PhfS=> MX:3NkBpenN? MWnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNU2xOOTNiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VWyCjc4PhfUwhUUN3MDC9JFAvODB2NzFOwG0v M2TsS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7M{WwPVIxLz5{OUO1NFkzODxxYU6=
MV4-11 M{\tcWN6fG:2b4jpZ4l1gSCjc4PhfS=> NVLCbVM{PzJiaILz M2\jS2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1XPC1zMTDj[YxteyCjZoTldkA4OiCqcoOgZpkh[2WubDD0bZRmei2kbIXlJIF{e2G7LDDJR|UxKD1iMD6wNVIh|ryPLh?= NH[0ZoI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOU[1OFQxQCd-MUm2OVQ1ODh:L3G+
RS4-11 NYDJcVhoTnWwY4Tpc44h[XO|YYm= NHL1NWIzKGi{cx?= MlfMTY5pcWKrdHnvckBw\iCITGSzJGlVTCCvdYThcpQh[XW2b4Doc5NxcG:{eXzheIlwdiCrbjDoeY1idiCUU{StNVEh[2WubIOgZYZ1\XJiMjDodpMh[nliZXzlZ5Rzd2OqZX3pcJVucW6nc3PlcoNmKGG|c3H5MEBKSzVyIE2gNE4xOTNizszNMi=> M4LhOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NkW0OFA5Lz5zOU[1OFQxQDxxYU6=
RS4-11 NYD6[HExTnWwY4Tpc44h[XO|YYm= NYf1SYt4OiCqcoO= MVjJcohq[mm2aX;uJI9nKE[OVEOgZZV1d3Cqb4PwbI9zgWyjdHnvckBqdiCqdX3hckBTWzRvMUGgZ4VtdHNiYX\0[ZIhOiCqcoOgZpkh\WynY4Tyc4Np\W2rbIXtbY5me2OnbnPlJIF{e2G7LDDJR|UxKD1iMD6wNVUh|ryPLh?= MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTZ3NESwPEc,OTl4NUS0NFg9N2F-
Sf9 NYXlNnNlTnWwY4Tpc44h[XO|YYm= MlriOEBpenN? NYS3PHQ1UW6qaXLpeIlwdiCxZjD3bYxlKHS7cHWgS3NVNXSjZ3fl[EBHVFR|IHvpcoF{\SCmb33hbY4hMFl3NkegeI8hWzl7MzmgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO|ZXSgbY4h[mGldXzveolzfXNiaX7m[YN1\WRiaX7z[YN1KFOoOTDj[YxteyC3c3nu[{BJ\XJ{IIDldJRq\GViYYOgd5Vje3S{YYTlJIFnfGW{IESgbJJ{KGK7IFvpcoF{\S2JbH:gZZN{[XluIFnDOVAhRSByLkCzO{DPxE1w NXu1cnN6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[wPFExOjNpPkK2NFgyODJ|PD;hQi=>
MV4-11 Mn:4SpVv[3Srb36gZZN{[Xl? NULNR5F7PzJiaILz MVXJcohq[mm2aX;uJI9nKE[OVEOgTXRFKGixbX;6fYdwfXNibYX0ZY51KGmwIHj1cYFvKE2YND2xNUBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuIHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCPVGOgZZN{[XluIFfJOVAhRSByLkCzPEDPxE1w Mkf0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyOEGwNlMoRjJ4MEixNFI{RC:jPh?=
MOLM-13 NWXT[VE4TnWwY4Tpc44h[XO|YYm= NET2Zm44OiCqcoO= MmXHTY5pcWKrdHnvckBw\iCITGSzJGlVTCCqZYTldo97gWexdYOgcZV1[W62IHnuJIh2dWGwIF3PUG0uOTNiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgUXRUKGG|c3H5MEBIUTVyIE2gNE4xPTVizszNMi=> M4XNSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MEixNFI{Lz5{NkC4NVAzOzxxYU6=
Sf9 NEHhZVlHfW6ldHnvckBie3OjeR?= MmPNPVAhdWmwcx?= M3ywNWlvcGmkaYTpc44hd2ZicnXjc41jcW6jboSgS3NVNXSjZ3fl[EBCfXKxcnGtRUBscW6jc3Wg[I9u[WmwIDjTNVI{KHSxIGO0NFEqKCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIHnud4VkfCCVZkmgZ4VtdHNidYPpcochfGW2cnGoUHJTSVOORzmgdIVxfGmmZTDhd{B{fWK|dILheIUh[W[2ZYKgPVAhdWmwczDifUBMcW6jc3WtS4xwKGG|c3H5MEBKSzVyIE2gNE4xQCEQvF2u NHzy[m09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkC4NVAzOyd-Mk[wPFExOjN:L3G+
FDC-P1 NIDnTJJHfW6ldHnvckBie3OjeR?= NGLyNZk1QCCqcoO= MljzTY5pcWKrdHnvckBw\iCqdX3hckBHVVNiZYjwdoV{e2WmIHnuJIdzd3e2aDDmZYN1d3JiZHXw[Y5l\W62IH3veZNmKE[GQz3QNUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIF\NV{1u\WSrYYTl[EBk\WyuIIDyc4xq\mW{YYTpc44hcW5icILld4Vv[2ViaIXtZY4hS1OIMTDh[pRmeiB2ODDodpMh[nlicnXzZZp2emmwIHT5[UBz\WS3Y4Tpc44h[XO|YYmsJGlEPTBiPTCwMlE1OiEQvF2u NULpWXZrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxOVY3QDlpPkKwNVU3Pjh7PD;hQi=>
A375 NEGzVpRVd3irY3n0fUBie3OjeR?= Mkj3O|IhcHK| NYW0Znp6XG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBN|c2KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDj[YxtKHSrdHXyMYJtfWViYYPzZZktKEmFNUCgQUAxNjF6IN88UU4> M2\JbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NkW0OFA5Lz5zOU[1OFQxQDxxYU6=
FDC-P1 NHyz[nVHfW6ldHnvckBie3OjeR?= MYm0PEBpenN? NYP5XXVTUW6qaXLpeIlwdiCxZjDtc5V{\SCJTT3DV2Yue3SrbYXsZZRm\CClZXzsJJBzd2yrZnXyZZRqd25ib3[g[5Jwf3SqIH\hZ5RweiCmZYDlcoRmdnRibX;1d4UhTkSFLWCxJINmdGy|IHX4dJJme3OrbnegbJVu[W5iRl3TJIFnfGW{IES4JIhzeyCkeTDy[ZNignW{aX6g[JlmKHKnZIXjeIlwdiCjc4PhfUwhUUN3MDC9JFAvOiEQvF2u MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF3Nk[4PUc,OjBzNU[2PFk9N2F-
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Sf9 NWHTcW1TTnWwY4Tpc44h[XO|YYm= NH:0e40yOjBibXnudy=> M3f4dmlvcGmkaYTpc44hd2ZicnXjc41jcW6jboSgS3NVNXSjZ3fl[EBXTUeIUkKgb4lv[XOnIHTvcYFqdiBqVke4PUB1dyCYMUO1OkkhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5iaX7z[YN1KFOoOTDj[YxteyC3c3nu[{Bxd2y7R3z1OFpVgXJicHXweIll\SCjczDzeYJ{fHKjdHWgZYZ1\XJiMUKwJI1qdnNiYomgT4lv[XOnLVfsc{Bie3OjeTygTWM2OCB;IECuNlUh|ryPLh?= MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjB6MUCyN{c,OjZyOEGwNlM9N2F-
RS4:11 NGrKN3lHfW6ldHnvckBie3OjeR?= MV:3NkBpenN? NYT6NnJLUW6qaXLpeIlwdiCxZjD3bYxlKHS7cHWgbI9ud3q7Z3;1d{BHVFR|IHnuJIh2dWGwIGLTOFoyOSClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDNWHMh[XO|YYmsJGdKPTBiPTCwMlQh|ryPLh?= MlrMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyOEGwNlMoRjJ4MEixNFI{RC:jPh?=
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SJ-GBM2 NGnwdlJyUFSVIHHzd4F6 Mn;3dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKFOMLVfCUVIh[2WubIO= NUjvcHBqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
A673 NXq3d4ZDeUiWUzDhd5NigQ>? MYfxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhSTZ5MzDj[Yxtew>? NYTQSWN7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
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COR-L23 NGDmTnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPJe2ZKdmirYnn0bY9vKG:oIHj1cYFvKEORUj3MNlMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDFzLkG4O|gh|ryPLh?= MknSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOlA5PTN|Lze+V2FPT0WUPD;hQi=>
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NCI-H446 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTVNHBKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOFQ3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSBzND6zOVM2KM7:TT6= NFq5S409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw3ODh3M{OvK|5USU6JRWK8M4E,
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T84 NGH3OGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoezTY5pcWKrdHnvckBw\iCqdX3hckBVQDRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEG2MlQ1QTdizszNMi=> MnjzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOlA5PTN|Lze+V2FPT0WUPD;hQi=>
ME-180 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPxeZUxUW6qaXLpeIlwdiCxZjDoeY1idiCPRT2xPFAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDF5LkS2N|Ih|ryPLh?= M3ntTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFYxQDV|Mz:nQnNCVkeHUkyvZV4>
LP-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHYbo9KdmirYnn0bY9vKG:oIHj1cYFvKEySLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFE4NjVyNkKg{txONg>? MoryQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOlA5PTN|Lze+V2FPT0WUPD;hQi=>
DMS-153 Mm[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjDZmlIUW6qaXLpeIlwdiCxZjDoeY1idiCGTWOtNVU{KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSBzOD6wNVY3KM7:TT6= MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly2NFg2OzNxJ{7TRW5ITVJ:L3G+
SW1463 MkHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHLR2dKUW6qaXLpeIlwdiCxZjDoeY1idiCVV{G0OlMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDF6LkG3OFEh|ryPLh?= NX;INFJCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPjB6NUOzM{c,W0GQR1XSQE9iRg>?
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CAL-148 NGDkS3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnERZBKdmirYnn0bY9vKG:oIHj1cYFvKEODTD2xOFgh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDF6LkW0N{DPxE1w MkO1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOlA5PTN|Lze+V2FPT0WUPD;hQi=>
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HPAF-II NGXlfplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVi2T2NGUW6qaXLpeIlwdiCxZjDoeY1idiCKUFHGMWlKKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSBzOT60PFcyKM7:TT6= NV34SXJoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPjB6NUOzM{c,W0GQR1XSQE9iRg>?
CAL-72 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHKe5hKdmirYnn0bY9vKG:oIHj1cYFvKEODTD23NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOjBwMUe3OUDPxE1w MliyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOlA5PTN|Lze+V2FPT0WUPD;hQi=>
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Assay
Methods Test Index PMID
Western blot PKCα / PKCβ1 / PKCβ2 / PKCγ / PKCη / p-PKC / p-Bad / Bad / p-Bcl2 / Bcl-2 / p-p65 / p65 p-TYR / p-STAT5 / STAT5 / p-S6 / S6 / p-MAPK / MAPK / p-AKT / AKT 30584254 28881711
体内研究 Midostaurin(pkc412) 除了直接抑制肿瘤细胞增殖(通过作用于PKCs),还通过抑制肿瘤血管生成(通过作用于VEGF受体酪氨酸激酶)来抑制肿瘤的生长。Midostaurin(pkc412)与细胞毒性剂,包括Doxorubicin, Cyclophosphamide, Cisplatin 和 Gemcitabine协同作用,产生的抗血管生成作用可能有助于抗转移和广泛的抗肿瘤活性。Midostaurin(pkc412)口服给药,最大耐受剂量为300 mg/kg以上。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:[2]
  • Cell lines: A549, NCI-H520
  • Concentrations: ~1.0 μM
  • Incubation Time: 24-72 小时
  • Method: 每孔加入5 mM WST-1和0.2 mM 1-甲氧基PMS,然后使用酶标仪在450nm处测量吸光度。
动物实验:[1]
  • Animal Models: Colo 205 结肠移植瘤
  • Dosages: 50 mg/kg, 200 mg/kg, 每天一次
  • Administration: 口服处理

溶解度(25°C)

体外

体内

从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5% DMSO+45% PEG 300+ddH2O

4mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 570.64
化学式

C35H30N4O4

CAS号 120685-11-2
储存条件 3年 -20°C 粉状
2年 -80°C 溶于溶剂

动物体内配方计算器(澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)

mg/kg g μL

第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于μL DMSO溶液(母液浓度mg/mL,:如该浓度超过该批次药物DMSO溶解度,请先联系Selleck);

体内配方配制方法:μL DMSO母液,加入μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入μL ddH2O,混匀澄清。

体内配方配制方法:μL DMSO母液,加入μL Corn oil,混匀澄清。

注意:1. 首先保证母液是澄清的;
2.一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。

摩尔浓度计算器

质量 浓度 体积 分子量

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03951961 Terminated Drug: Midostaurin Acute Myeloid Leukemia Adult University of Jena|Ludwig-Maximilians - University of Munich March 20 2020 Phase 2
NCT04097470 Active not recruiting Drug: Decitabine|Drug: Midostaurin AML/MDS Stichting Hemato-Oncologie voor Volwassenen Nederland|Swiss Group for Clinical Cancer Research December 5 2019 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-08-01)

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