Midostaurin (PKC412)

For research use only. Not for use in humans.

目录号:S8064 别名: CGP 41251 中文名称:米哚妥林

Midostaurin (PKC412) Chemical Structure

CAS No. 120685-11-2

Midostaurin (pkc412, CGP 41251) 是一种多靶点激酶抑制剂,作用于PKCα/β/γSykFlk-1AktPKAc-Kitc-Fgrc-SrcFLT3PDFRβVEGFR1/2IC50为80-500 nM。

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客户使用Selleck生产的Midostaurin (PKC412)发表文献32篇:

产品安全说明书

PKC抑制剂选择性比较

生物活性

产品描述 Midostaurin (pkc412, CGP 41251) 是一种多靶点激酶抑制剂,作用于PKCα/β/γSykFlk-1AktPKAc-Kitc-Fgrc-SrcFLT3PDFRβVEGFR1/2IC50为80-500 nM。
靶点
PKCα [1]
(Cell-free assay)
PKCγ [1]
(Cell-free assay)
PKCβ1 [1]
(Cell-free assay)
PKCβ2 [1]
(Cell-free assay)
PPK [1]
(Cell-free assay)
22 nM 24 nM 30 nM 31 nM 38 nM
体外研究

Midostaurin(pkc412)是一种广谱的蛋白激酶抑制剂。Midostaurin(pkc412)强烈与常规PKC-α, -β 和 -γ, PDGFRβ, VEGF-R2, VEGF-R1,及CDK 1-cyclin B复合物的ATP结合位点相互作用。Midostaurin(pkc412)在相似的亚微摩尔浓度时,在体外抑制多种人类和动物细胞系的生长。Midostaurin(pkc412) 在体外也有效抑制胶质母细胞瘤增殖,且诱导细胞在G2/M期累积,并形成巨核,具有广泛的碎片和凋亡小体。Midostaurin(pkc412)在体外能够逆转肿瘤细胞中p-糖蛋白介导的多药耐药性。[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EOL-1 MWXDfZRwfG:6aXPpeJkh[XO|YYm= MX63NkBpenN? Mnv5R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gSW9NNTFiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VWyCjc4PhfUwhUUN3MDC9JFAvODB|ODFOwG0v MnW3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl|NUC5NlAoRjJ7M{WwPVIxRC:jPh?=
MOLM13 NX7CPFVXS3m2b4TvfIlkcXS7IHHzd4F6 MXy3NkBpenN? M1LCT2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1QVE1zMzDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSVIHHzd4F6NCCLQ{WwJF0hOC5yMES3JO69VS5? MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTN3MEmyNEc,Ojl|NUC5NlA9N2F-
MV4-11 MVTDfZRwfG:6aXPpeJkh[XO|YYm= MnrPO|IhcHK| NUnRW4llS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVVZ2LUGxJINmdGy|IHHmeIVzKDd{IHjyd{BjgSClZXzsJJRqfGW{LXLseYUh[XO|YYmsJGlEPTBiPTCwMlAyOiEQvF2u MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTZ3NESwPEc,OTl4NUS0NFg9N2F-
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RS4-11 NGnxOoxHfW6ldHnvckBie3OjeR?= M4\uUlIhcHK| NWm4Vpp3UW6qaXLpeIlwdiCxZjDGUHQ{KGG3dH;wbI9{eGixconsZZRqd25iaX6gbJVu[W5iUmO0MVEyKGOnbHzzJIFnfGW{IEKgbJJ{KGK7IHXs[YN1em:laHXtbYx2dWmwZYPj[Y5k\SCjc4PhfUwhUUN3MDC9JFAvODF3IN88UU4> NHmzZoE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOU[1OFQxQCd-MUm2OVQ1ODh:L3G+
Sf9 NYDrdFIzTnWwY4Tpc44h[XO|YYm= M37TbFQhcHK| NUi5V|BqUW6qaXLpeIlwdiCxZjD3bYxlKHS7cHWgS3NVNXSjZ3fl[EBHVFR|IHvpcoF{\SCmb33hbY4hMFl3NkegeI8hWzl7MzmgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO|ZXSgbY4h[mGldXzveolzfXNiaX7m[YN1\WRiaX7z[YN1KFOoOTDj[YxteyC3c3nu[{BJ\XJ{IIDldJRq\GViYYOgd5Vje3S{YYTlJIFnfGW{IESgbJJ{KGK7IFvpcoF{\S2JbH:gZZN{[XluIFnDOVAhRSByLkCzO{DPxE1w MnPTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyOEGwNlMoRjJ4MEixNFI{RC:jPh?=
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FDC-P1 NIPWdWtHfW6ldHnvckBie3OjeR?= MnPBOFghcHK| Mm\kTY5pcWKrdHnvckBw\iCvb4Xz[UBIVS2FU1[td5RqdXWuYYTl[EBk\WyuIIDyc4xq\mW{YYTpc44hd2ZiZ4Lve5RpKG[jY4TvdkBl\XCnbnTlcpQhdW:3c3WgSmRENVBzIHPlcIx{KGW6cILld5NqdmdiaIXtZY4hTk2VIHHmeIVzKDR6IHjyd{BjgSC{ZYPhfpVzcW5iZInlJJJm\HWldHnvckBie3OjeTygTWM2OCB;IECuNkDPxE1w NVnXeFI{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxOVY3QDlpPkKwNVU3Pjh7PD;hQi=>
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NCI-H748 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KN{S4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUA5NjB4N{e4JO69VS5? MkDGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOlA5PTN|Lze+V2FPT0WUPD;hQi=>
LB771-HNC MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXL[GZZUW6qaXLpeIlwdiCxZjDoeY1idiCOQke3NU1JVkNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEiuNVM5OyEQvF2u NInhVW49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw3ODh3M{OvK|5USU6JRWK8M4E,
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ATN-1 NEToXYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXIN2NKdmirYnn0bY9vKG:oIHj1cYFvKEGWTj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUA5NjZ3Mkm1JO69VS5? MkS5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOlA5PTN|Lze+V2FPT0WUPD;hQi=>
HAL-01 NUjEXmpGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfKUppMUW6qaXLpeIlwdiCxZjDoeY1idiCKQVytNFEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDhwN{S0NVMh|ryPLh?= MnzNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOlA5PTN|Lze+V2FPT0WUPD;hQi=>
LU-139 M3PsZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlniTY5pcWKrdHnvckBw\iCqdX3hckBNXS1zM{mgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFgvQTJ4MUWg{txONg>? NG\4N2o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw3ODh3M{OvK|5USU6JRWK8M4E,
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NCI-H1694 M4C3eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMU[5OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hQS5|N{K1N{DPxE1w MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly2NFg2OzNxJ{7TRW5ITVJ:L3G+
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NCI-H1092 NFnsb45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHWTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEGwPVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDlwN{myOVMh|ryPLh?= MorlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOlA5PTN|Lze+V2FPT0WUPD;hQi=>
AsPC-1 NIn1NWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV22RmVCUW6qaXLpeIlwdiCxZjDoeY1idiCDc2DDMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDlwOEW5N|Uh|ryPLh?= MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly2NFg2OzNxJ{7TRW5ITVJ:L3G+
MHH-CALL-2 M3XuOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV36UmZ3UW6qaXLpeIlwdiCxZjDoeY1idiCPSFitR2FNVC1{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTCxNE4xOTZ7IN88UU4> M1LPeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFYxQDV|Mz:nQnNCVkeHUkyvZV4>
NCI-SNU-5 MoTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1O2SGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLWPOWU02KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSBzMD6zNlQzKM7:TT6= NEHFe209[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw3ODh3M{OvK|5USU6JRWK8M4E,
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NCI-H727 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVX1e2R3UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFczPyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iMUGuNVM6OiEQvF2u MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly2NFg2OzNxJ{7TRW5ITVJ:L3G+
COR-L23 NIPOTI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;LO|lKdmirYnn0bY9vKG:oIHj1cYFvKEORUj3MNlMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDFzLkG4O|gh|ryPLh?= NVvCZpVyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPjB6NUOzM{c,W0GQR1XSQE9iRg>?
U-118-MG MnP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fQcWlvcGmkaYTpc44hd2ZiaIXtZY4hXS1zMUitUWch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDFzLkK3O|kh|ryPLh?= NXL5T49LRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPjB6NUOzM{c,W0GQR1XSQE9iRg>?
GAK NIPROYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DkUGlvcGmkaYTpc44hd2ZiaIXtZY4hT0GNIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTCxNU4{OzR6IN88UU4> M3n5WVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFYxQDV|Mz:nQnNCVkeHUkyvZV4>
HCC2998 NYexT2V5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJcohq[mm2aX;uJI9nKGi3bXHuJGhESzJ7OUigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFEyNjR{NUGg{txONg>? NEDmSo09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw3ODh3M{OvK|5USU6JRWK8M4E,
COLO-829 M1S0c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTQPZhKdmirYnn0bY9vKG:oIHj1cYFvKEORTF:tPFI6KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSBzMT62NVkzKM7:TT6= NYLjUmk5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPjB6NUOzM{c,W0GQR1XSQE9iRg>?
CAL-33 MkDES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\HbHhLUW6qaXLpeIlwdiCxZjDoeY1idiCFQVytN|Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDFzLkm5OFYh|ryPLh?= NGKx[3g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw3ODh3M{OvK|5USU6JRWK8M4E,
EB2 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3v3RWlvcGmkaYTpc44hd2ZiaIXtZY4hTUJ{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTCxNU46QTZ6IN88UU4> NGrLSJE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw3ODh3M{OvK|5USU6JRWK8M4E,
THP-1 NV7lV5hLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrUW4FKdmirYnn0bY9vKG:oIHj1cYFvKFSKUD2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAyOi5yN{S4JO69VS5? MknUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOlA5PTN|Lze+V2FPT0WUPD;hQi=>
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... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
PKCα / PKCβ1 / PKCβ2 / PKCγ / PKCη / p-PKC / p-Bad / Bad / p-Bcl2 / Bcl-2 / p-p65 / p65; 

PubMed: 30584254     


The indicated PKC isoforms were up-regulated in the resistant BL cells, leading to elevated levels of PKC phosphorylation and the activation of downstream anti-apoptotic proteins.

p-TYR / p-STAT5 / STAT5 / p-S6 / S6 / p-MAPK / MAPK / p-AKT / AKT ; 

PubMed: 28881711     


Effect of midostaurin and PRT062607 on TEL-SYK phosphorylation and phosphorylation of downstream effectors following 2 hr of treatment. For the experiment analyzing effects of midostaurin and PRT062607 on phosphorylation of TEL-SYK, SYK immunoprecipitation was carried out prior to immunoblotting with a PTYR (4G10) antibody. Immunoblotting was performed for the experiment analyzing effects of midostaurin and PRT062607 on signaling molecules downstream of TEL-SYK. Relative densitometry readings for pMAPK/total MAPK (normalized to control lane) are as follows: 0 nM midostaurin=1.0, 10 nM midostaurin=0.93, 100 nM midostaurin=0.41, 1000 nM midostaurin=0.04, 0 nM PRT062607=1.0, 10 nM PRT062607=0.72, 100 nM PRT062607=0.37, 1000 nM PRT062607=0.07. 

30584254 28881711
体内研究 Midostaurin(pkc412) 除了直接抑制肿瘤细胞增殖(通过作用于PKCs),还通过抑制肿瘤血管生成(通过作用于VEGF受体酪氨酸激酶)来抑制肿瘤的生长。Midostaurin(pkc412)与细胞毒性剂,包括Doxorubicin, Cyclophosphamide, Cisplatin 和 Gemcitabine协同作用,产生的抗血管生成作用可能有助于抗转移和广泛的抗肿瘤活性。Midostaurin(pkc412)口服给药,最大耐受剂量为300 mg/kg以上。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:[2]
- 合并
  • Cell lines: A549, NCI-H520
  • Concentrations: ~1.0 μM
  • Incubation Time: 24-72 小时
  • Method: 每孔加入5 mM WST-1和0.2 mM 1-甲氧基PMS,然后使用酶标仪在450nm处测量吸光度。
    (Only for Reference)
动物实验:[1]
- 合并
  • Animal Models: Colo 205 结肠移植瘤
  • Dosages: 50 mg/kg, 200 mg/kg, 每天一次
  • Administration: 口服处理
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 100 mg/mL (175.24 mM)
Water Insoluble
Ethanol ''''''20 mg/mL warmed
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5% DMSO+45% PEG 300+ddH2O
4mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 570.64
化学式

C35H30N4O4

CAS号 120685-11-2
储存条件 粉状
溶于溶剂
别名 CGP 41251

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03951961 Terminated Drug: Midostaurin Acute Myeloid Leukemia Adult University of Jena|Ludwig-Maximilians - University of Munich March 20 2020 Phase 2
NCT04097470 Active not recruiting Drug: Decitabine|Drug: Midostaurin AML/MDS Stichting Hemato-Oncologie voor Volwassenen Nederland|Swiss Group for Clinical Cancer Research December 5 2019 Phase 2

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操作手册

如果有其他问题,请给我们留言。

  • * 必填项

PKC Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID