Phorbol 12-myristate 13-acetate (PMA)

For research use only. Not for use in humans.

目录号:S7791 别名: 12-O-Tetradecanoylphorbol-13-acetate,TPA

Phorbol 12-myristate 13-acetate (PMA) Chemical Structure

CAS No. 16561-29-8

Phorbol 12-myristate 13-acetate (PMA, 12-O-Tetradecanoylphorbol-13-acetate, TPA)是一种有效的PKC激活剂,在纳摩尔浓度范围内具有活性作用。Phorbol 12-myristate 13-acetate (PMA)可诱导sphingosine-1-phosphate (S1P)

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 2022.93 现货
RMB 1273.34 现货
RMB 4807.89 现货
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客户使用Selleck生产的Phorbol 12-myristate 13-acetate (PMA)发表文献18篇:

产品安全说明书

PKC抑制剂选择性比较

生物活性

产品描述 Phorbol 12-myristate 13-acetate (PMA, 12-O-Tetradecanoylphorbol-13-acetate, TPA)是一种有效的PKC激活剂,在纳摩尔浓度范围内具有活性作用。Phorbol 12-myristate 13-acetate (PMA)可诱导sphingosine-1-phosphate (S1P)
Assay
Methods Test Index PMID
Western blot
pERK / ERK1 / pp38 / p38 ; 

PubMed: 22977714     


The effect of PMA on the phosphorylations of ERK1/2 and p38 MAPK in the NCI-H292 airway epithelial cells. The phosphorylation of ERK1/2 and p38 were detected using Western blot analysis. PMA activated phosphorylation of p38 MAPK, while it did not activate phosphorylation of ERK1/2. ERK, extracellular signal-regulated kinase; PMA, phorbol 12-myristate 13-acetate; MAPK, mitogen-activated protein kinase.

p-GSK3β / GSK3β / Lamin B2 ; 

PubMed: 27405982     


The amount of p-GSK3β in the nuclear/cytoplasmic fraction was examined by Western blotting after PMA (1 μM) treatment. Lamin B2 was used as a loading control for the nuclear fraction. *p < 0.05, versus control. c control, D1 1 day after PMA treatment, D3 3 days after PMA treatment, D6 6 days after PMA treatment, GSK3β glycogen synthase kinase 3 beta, PMA phorbol 12-myristate 13-acetate

22977714 27405982
Immunofluorescence
cTnT / β-MHC / CD90 ; 

PubMed: 27405982     


Expression of cardiac and stem cell markers in PMA-treated hMSCs. Immunocytochemical analysis was performed to detect the expression of a cTnT (scale bar = 100 μm), b β-MHC (scale bar = 100 μm), and c CD90 (scale bar = 40 μm) at 9 days after PMA (1 μM) treatment. DAPI was used to stain the nucleus. d mRNA expression of β-MHC and cTnT in hMSCs treated with PMA for 9 days was detected by RT-PCR. *p < 0.05, versus control. cTnT cardiac troponin T, MHC myosin heavy chain, PMA phorbol 12-myristate 13-acetate.

27405982

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

体外 DMSO 100 mg/mL (162.11 mM)
Water Insoluble
Ethanol ''100 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 616.83
化学式

C36H56O8

CAS号 16561-29-8
储存条件 3年 -20°C(避光) 粉状
2年 -80°C(避光) 溶于溶剂
别名 12-O-Tetradecanoylphorbol-13-acetate,TPA

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04986839 Not yet recruiting Drug: Paracetamol injection|Drug: Ibuprofen injection Patent Ductus Arteriosus Manchester University NHS Foundation Trust October 1 2021 Phase 2|Phase 3
NCT04251377 Not yet recruiting Device: Defensive Antiadhesive Coating DAC® Novagenit SRL Hip Prosthesis Infection Centre Hospitalier Universitaire de Saint Etienne|Ministry of Health France September 2021 Not Applicable
NCT04372953 Recruiting Procedure: Positive End-Expiratory Pressure (PEEP) Lung Injury|Preterm Birth Murdoch Childrens Research Institute|University of Pennsylvania|Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) May 4 2021 Not Applicable
NCT04531566 Recruiting Dietary Supplement: Oral Feed|Dietary Supplement: Usual care Premature Birth The University of Texas Health Science Center Houston October 20 2020 Not Applicable

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID