Niclosamide (BAY2353)

For research use only. Not for use in humans.

目录号:S3030 别名: Niclocide, NSC 178296 中文名称:氯硝柳胺

Niclosamide (BAY2353) Chemical Structure

CAS No. 50-65-7

Niclosamide (BAY2353, Niclocide, NSC 178296)能够抑制DNA复制,并抑制STAT3,无细胞试验中IC50为0.7 μM。 Niclosamide 选择性地抑制STAT3的磷酸化,对其他同系物如STAT1和STAT5的激活没有明显抑制作用。

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客户使用Selleck生产的Niclosamide (BAY2353)发表文献30篇:

产品安全说明书

STAT抑制剂选择性比较

生物活性

产品描述 Niclosamide (BAY2353, Niclocide, NSC 178296)能够抑制DNA复制,并抑制STAT3,无细胞试验中IC50为0.7 μM。 Niclosamide 选择性地抑制STAT3的磷酸化,对其他同系物如STAT1和STAT5的激活没有明显抑制作用。
靶点
STAT3 [1]
(in Hela cells)
0.7 μM
体外研究

Niclosamide (< 5 μM)剂量依赖性抑制STAT3介导的荧光素酶报告基因活性,HeLa细胞中IC50 为0.25 μM。Niclosamide(< 2 μM)剂量依赖性抑制Du145细胞中STAT3的磷酸化。Niclosamide (1 μM)抑制Du145细胞中EGF诱导的STAT3的细胞核易位。Niclosamide(< 2 μM)剂量依赖性抑制Du145细胞中STAT3下游基因的转录。Niclosamide(< 10 μM)剂量依赖性诱导G0/G1期阻滞和Du145癌症细胞的凋亡。[1]在感染SARS-CoV的Vero E6细胞中,Niclosamide在微摩尔浓度下能够抑制SARS-CoV复制。[2] 在U2OS 细胞中,Niclosamide(< 7.5 μM)促进Frizzled1的内吞作用,下调Dishevelled-2蛋白,并抑制Wnt3A刺激的β-连环蛋白稳定化和LEF/TCF报告基因活性。[3]U2OS 细胞中,Niclosamide以剂量和时间依赖的方式抑制TNF诱导的NF-κB报告基因活性。Niclosamide(125 nM)抑制U2OS 细胞中p65,IKKα,IKKβ,IKKγ,和TAK1诱导的NF-κB活化。Niclosamide(< 500 nM)完全阻断HL-60细胞中时间和剂量依赖性TNFα诱导的NF-κB–DNA复合物的改变。Niclosamide(< 10 nM)抑制U266细胞中组成型NF-κB的活化。在HL-60,Molm13,或AML原代细胞中,Niclosamide以时间和剂量依赖的方式抑制TNF诱导的IκBα降解和p65重定位。HL-60细胞中,Niclosamide(500 nM)减少TNF诱导的NF-κB依赖性基因产物,包括细胞存活。Niclosamide剂量依赖性抑制生长,并诱导强烈的AML细胞凋亡,与Mcl-1和XIAP水平的减少和细胞内ROS水平的增加相关。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PC3 NHezTVJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M2DHNVEzOCCqcoO= NUfmZ|ZGSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOgZYZ1\XJiMUKwJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MD60{txO M2Hu[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NkiwNVU6Lz5zNk[4NFE2QTxxYU6=
A549 MXHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MmTDNVIxKGi{cx?= M4rOWWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDh[pRmeiBzMkCgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1yLkVOwG0> NVvz[G1NRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[2PFAyPTlpPkG2OlgxOTV7PD;hQi=>
U87MG MVXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? Mm\TNVIxKGi{cx?= MlzQRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCXOEfNS{Bk\WyuczDh[pRmeiBzMkCgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1yLkVOwG0> NWC3eWQ{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[2PFAyPTlpPkG2OlgxOTV7PD;hQi=>
LoVo MY\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MYSxNlAhcHK| NVjGOIcySW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDMc3ZwKGOnbHzzJIFnfGW{IEGyNEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUCuO:69VQ>? NE[wZXQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNk[4NFE2QSd-MU[2PFAyPTl:L3G+
MIAPaCa2 NFfOb4RCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NVTBeppbOTJyIHjydy=> MV3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2LQWDhR4Ez[2WubIOgZYZ1\XJiMUKwJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MT6x{txO M1jyS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NkiwNVU6Lz5zNk[4NFE2QTxxYU6=
PC3 NXPHUoZbTnWwY4Tpc44h[XO|YYm= NFLFSpIyKGi{ NF3we4VKdmirYnn0bY9vKG:oIH3peI9kcG:wZILpZYwhdWWvYoLhcoUheG:2ZX70bYFtKGmwIHj1cYFvKFCFMzDj[YxteyCjZoTldkAyKGi{ MmrKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ4OECxOVkoRjF4NkiwNVU6RC:jPh?=
HEK293 NYjXRZBQTnWwY4Tpc44h[XO|YYm= NF7HWY0yKGi{ Mln3TY5pcWKrdHnvckBw\iCvaYTvZ4hwdmS{aXHsJI1mdWK{YX7lJJBwfGWwdHnhcEBqdiCqdX3hckBJTUt{OUOgZ4VtdHNiYX\0[ZIhOSCqch?= MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjZ6MEG1PUc,OTZ4OECxOVk9N2F-
neural precursor M361NWZ2dmO2aX;uJIF{e2G7 MVfJcohq[mm2aX;uJI9nKG6ndYLvd5Bp\XKnIIDyc4xq\mW{YYTpc44hd2ZibX;1d4UhdmW3cnHsJJBz\WO3coPvdkBk\WyuczDifUBOXFRiYYPzZZk> NHnPR409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{SxO|Y{OSd-MUe0NVc3OzF:L3G+
Vero E6 MX3BcpRqfmm{YXygZZN{[Xl? NFj5TmNCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBUSVKVIHPvdo9v[X[rcoXzJIlvKF[ncn:gSVYh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJidCC{ZYDsbYNifGmxbjDifUBGVEmVQTygSWM2ODxyLkJOwG0> NYLQUIo{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2OlM2OzlpPkG3OlY{PTN7PD;hQi=>
Vero E6 NFvQU41EgXSxdH;4bYNqfHliYYPzZZk> MnnlR5l1d3SxeHnjbZR6KGGpYXnud5QhXmW{bzDFOkBk\WyuczDifUBOXFRiYYPzZZktKEOFNUC9NlIvOc7:TR?= NVX5eGF1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2OlM2OzlpPkG3OlY{PTN7PD;hQi=>
RAW264.7 MUPDfZRweHKxdHXjeIl3\SCjc4PhfS=> Mlf0NVAhfU1? NY\ZZ2o2S3m2b4Dyc5Rm[3SrdnWgZYN1cX[rdImgZYdicW6|dDDhcpRpemG6IITvfIlvKGyndHjhcEBn[WO2b4KvdJJwfGWldHn2[UBidnSrZ3XuMYlv\HWlZXSgZ4VtdCCmZXH0bEBqdiCvb4Xz[UBTSVd{NkSuO{Bk\WyuczDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDheEAyOCC3TTDifUBOXFRicnXkeYN1cW:wIHHzd4F6 M3v1bFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NUSwO|Y1Lz5zOUW0NFc3PDxxYU6=
CHO MkC4R5l1d3C{b4TlZ5RqfmViYYPzZZk> NXLQb4JjS3m2b4Dyc5Rm[3SrdnWgZYN1cX[rdImgZYdicW6|dDDhcpRpemG6IH\1d4lwdiC2b4jpckBHWDV7LXnu[JVk\WRiY3XscEBl\WG2aDDpckBEUE9iY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[nliTWTUJJJm\HWldHnvckBie3OjeR?= NXrS[m9yRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm1OFA4PjRpPkG5OVQxPzZ2PD;hQi=>
CHO NXuyd5U2TnWwY4Tpc44h[XO|YYm= MoPZTY5pcWKrdHnvckBw\iCEYXPpcIx2eyCjboTodoFkcXNiYX70bJJigCCycn;0[YN1cX[nIHHueIlo\W5iaHXweIFu\XJicILlMZBwemVidH:gdI9z\SClb372[ZJ{cW:wIHnuJGNOTzJvZYjwdoV{e2mwZzDDTG8h[2WubIO= NGf5SZc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUW0NFc3PCd-MUm1OFA4PjR:L3G+
Ava5 MmPkRY51cX[rcnHsJIF{e2G7 MWezJIRigXN? NX\CWY9ZSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEOYIHflco91gXCnIEHiJIlv\mWldHXkJIlvKEG4YUWgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYLhcEBz\XCuaXPheIlwdiCjZoTldkA{KGSjeYOgZpkh[myxdDDofYJzcWSrenH0bY9vKGGwYXz5d4l{NCCHQ{WwQVAvOTcQvF2= NW[0clBoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwOVk6QDNpPkKyNFU6QTh|PD;hQi=>
Ava5 M3HGPGFvfGm4aYLhcEBie3OjeR?= MXOzJIRigXN? MmSzRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGNXKGenbn;0fZBmKDGkIHnu[oVkfGWmIHnuJGF3[TViY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXKjbDDy[ZBtcWOjdHnvckBi\nSncjCzJIRigXNiYomgZoxwfCCqeXLybYRqgmG2aX;uJIFv[Wy7c3nzMEBGSzlyPUCuO:69VQ>? Mmq2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyNUm5PFMoRjJ{MEW5PVg{RC:jPh?=
Ava5 M{\MRWN6fG:2b4jpZ4l1gSCjc4PhfS=> NF7qR5o{KGSjeYO= NWHpbHhvS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSX[jNTDj[YxteyCjZoTldkA{KGSjeYOgZpkhdmW3dILhcEBz\WRiZInlJIF{e2G7LDDDR|UxRTFyzszN M{jkUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MEW5PVg{Lz5{MkC1PVk5OzxxYU6=
HFF NYTVTY42SW62aXHwbYNwdXCuZYjhckBie3OjeR?= NFy2[G0zPCCqcoO= NWPsNGFWSW62aXHwbYNwdXCuZYjhckBi[3Srdnn0fUBi\2GrboP0JHRwgG:ybHHzcYEh\2:wZHnpJHJJKHSjY3j5fo9qfGW|IHnu[oVkfGWmIHnuJGhHTiClZXzsd{Bie3Onc4Pl[EBieyCdM1jdMZVz[WOrbDDpcoNwenCxcnH0bY9vKGGodHXyJFI1KGi{czDifUB{[2mwdHnscIF1cW:wIHz1cYlv\XOlZX7j[UBkd3WwdHXyMEBOUUN7ME2wMlLPxE1? M1rSZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OUewPVM4Lz5{Mkm3NFk{PzxxYU6=
HFF NUizVHFRSW62aXHwbYNwdXCuZYjhckBie3OjeR?= NG[0V44zPCCqcoO= NX;uT|Z5SW62aXHwbYNwdXCuZYjhckBi[3Srdnn0fUBi\2GrboP0JHRwgG:ybHHzcYEh\2:wZHnpJHJJKHSjY3j5fo9qfGW|IHnu[oVkfGWmIHnuJGhHTiClZXzsd{Bie3Onc4Pl[EBieyCdM1jdMZVz[WOrbDDpcoNwenCxcnH0bY9vKGGodHXyJFI1KGi{czDifUB{[2mwdHnscIF1cW:wIHz1cYlv\XOlZX7j[UBkd3WwdHXyMEBOUUN3ME2wMlLPxE1? NHn5Z2c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mkm3NFk{Pyd-MkK5O|A6Ozd:L3G+
MDA-MB-231 M360PGN6fG:2b4jpZ4l1gSCjc4PhfS=> NXfoWpV2S1m2b4TvfIlkcXS7IHHnZYlve3RiRWKtcoVo[XSrdnWgbJVu[W5iTVTBMW1DNTJ|MTDj[YxteyCkeTDNWHMh[XO|YYmsJGlEPTB;MD63Pe69VQ>? M2\PV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NEG2NVkyLz5{M{SxOlE6OTxxYU6=
MCF7 MYLDfZRwfG:6aXPpeJkh[XO|YYm= Ml\RR3l1d3SxeHnjbZR6KGGpYXnud5QhTVJvcH;zbZRqfmViaIXtZY4hVUOINzDj[YxteyCkeTDNWHMh[XO|YYmsJGlEPTB;MT6wOu69VQ>? NX3SfYxERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0NVYyQTFpPkKzOFE3OTlzPD;hQi=>
AsPC1 MoDFR5l1d3SxeHnjbZR6KGG|c3H5 M{DUZmN[fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGF{WENzIHPlcIx{KGK7IF3UV{Bie3OjeTygTWM2OD1zLkS3{txO NGL5W249[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{SxOlE6OSd-MkO0NVYyQTF:L3G+
PANC1 M4HpfmN6fG:2b4jpZ4l1gSCjc4PhfS=> NEjHNlVEYXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSU6FMTDj[YxteyCkeTDNWHMh[XO|YYmsJGlEPTB;MT63N:69VQ>? M2jkXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NEG2NVkyLz5{M{SxOlE6OTxxYU6=
HEK293 NGHObmVHfW6ldHnvckBie3OjeR?= MXy4JIhzew>? NF\mXnhKdmirYnn0bY9vKG:oIGfueFNCN2KndHGtZ4F{\WmwIIPp[45idGmwZzDpckBJTUt{OUOgZ4VtdHNiYX\0[ZIhQCCqcoOgZpkhXE:SZnzhd4ghemWyb4L0[ZIh[XO|YYmsJGlEPTB;MD60{txO MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzR3M{C3N{c,OjN2NUOwO|M9N2F-
U2OS NIPNV4dHfW6ldHnvckBie3OjeR?= MojmNVIvPSC3TR?= M3LXd|YhcHK| NVLP[lE5UW6mdXP0bY9vKG:oIHnueIVzdmGuaYrheIlwdiCxZjDGdol7gmynZEGtS2ZRKCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIHj1cYFvKFV{T2OgZ4VtdHNiYYSgNVIvPSC3TTDh[pRmeiB4IHjyd{BjgSClb37mc4NidCCvaXPyc5Nkd3C7 NGDBSGQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S1N|A4Oyd-MkO0OVMxPzN:L3G+
MDA-MB-231 MXfDfZRwfG:6aXPpeJkh[XO|YYm= MVO3NkBpenN? MUfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDFVkBv\WejdHn2[UBOTEFvTVKtNlMyKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHMh[XO|YYmsJGlEPTB;MD63Pe69VQ>? NXm4ZXBjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0OVk3OTNpPkKzOFU6PjF|PD;hQi=>
MCF7 NW\IVVBES3m2b4TvfIlkcXS7IHHzd4F6 NV;0V2M2PzJiaILz NE\VPZFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBGWiCyb4PpeIl3\SCPQ1[3JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGOgZZN{[XluIFnDOVA:OS5yNt88US=> MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzR3OU[xN{c,OjN2NUm2NVM9N2F-
AsPC1 NYPIfWcyS3m2b4TvfIlkcXS7IHHzd4F6 NH61N4Y4OiCqcoO= NWDyV2VyS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSXOSQ{GgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WUzDhd5NigSxiSVO1NF0yNjR5zszN NV;sXFlKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0OVk3OTNpPkKzOFU6PjF|PD;hQi=>
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MDA-MB-231 M4X1fmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M2fkOVExKHSxIEKwJJVO Ml\NNlQhcHK| NVvFSnY{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDFVkBv\WejdHn2[UBOTEFvTVKtNlMyKGOnbHzzJIF1KDFyIITvJFIxKHWPIHHmeIVzKDJ2IHjyd{BjgSCPVGSgZZN{[Xl? NH3PXYI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S1PVYyOyd-MkO0OVk3OTN:L3G+
MDA-MB-231 NFLlTlBHfW6ldHnvckBie3OjeR?= M4TwTlI1KGi{cx?= M2PYWGlvcGmkaYTpc44hd2ZiU2TBWFMheHKxbX;0[ZIh[WO2aY\peJkhcW5iaIXtZY4hTVJibnXnZZRqfmViTVTBMW1DNTJ|MTDj[YxteyCjZoTldkAzPCCqcoOgZpkh\HWjbDDseYNq\mW{YYPlJJJmeG:{dHXyJIF{e2G7 MlPDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2NUm2NVMoRjJ|NEW5OlE{RC:jPh?=
MDA-MB-231 NXfodlMxTnWwY4Tpc44h[XO|YYm= NW[0XpRQOjBidV2= MkXENlQhcHK| NIO3PJRKdmirYnn0bY9vKG:oIGPURXQ{KHC{b33veIVzKGGldHn2bZR6KGmwIHj1cYFvKEWUIH7l[4F1cX[nIF3ERU1OSi1{M{GgZ4VtdHNiYYSgNlAhfU1iYX\0[ZIhOjRiaILzJIJ6KGS3YXygcJVkcW[ncnHz[UBz\XCxcoTldkBie3OjeR?= NHvp[Y49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S1PVYyOyd-MkO0OVk3OTN:L3G+
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MDA-MB-231 NXvDUFdCTnWwY4Tpc44h[XO|YYm= MYCxJJRwKDFyIIXN MYW0PEBpenN? NV;qV41LUW6mdXP0bY9vKG:oIH3vdpBpd2yxZ3njZYwh[2ijbnfld{BqdiCqdX3hckBGWiCwZXfheIl3\SCPRFGtUWIuOjNzIHPlcIx{KGG2IEGgeI8hOTBidV2gZYZ1\XJiNEigbJJ{KGK7IHzp[4h1KG2rY4Lvd4NweGmlIHHuZYx6e2m| MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzR3OU[xN{c,OjN2NUm2NVM9N2F-
MDA-MB-231 MofJSpVv[3Srb36gZZN{[Xl? MnvpNUB1dyBzMDD1US=> M1vWflQ5KGi{cx?= NYf4elJnUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDFVkBv\WejdHn2[UBOTEFvTVKtNlMyKGOnbHzzJIF1KDFidH:gNVAhfU1iYX\0[ZIhPDhiaILzJIJ6KGyrZ3j0JI1q[3Kxc3PvdIlkKGGwYXz5d4l{ MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzR3OU[xN{c,OjN2NUm2NVM9N2F-
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MDA-MB-231 M3\VfWZ2dmO2aX;uJIF{e2G7 M2\5[|EhfG9iMUCgeW0> NETBOIszPCCqcoO= M1LhN2lvcGmkaYTpc44hd2ZiU2TBWFMhcW5iaIXtZY4hTVJibnXnZZRqfmViTVTBMW1DNTJ|MTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4YheGixc4Doc5J6dGG2ZXSgV3RCXDNiYYSgWJlzNTdyNTDs[ZZmdCCjdDCxJJRwKDFyIIXNJIFnfGW{IEK0JIhzeyCkeTDX[ZN1\XKwIHLsc5Qh[W6jbInzbZM> NFfhUGo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S1PVYyOyd-MkO0OVk3OTN:L3G+
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DU145 M3y2ZWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M2DZRVczKGi{cx?= MlXCRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCGVUG0OUBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTBwN988US=> MknsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7MECyN|EoRjJ2OUCwNlMyRC:jPh?=
DU145 NVTTO2VNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEPBe5QyOSC2bzCxNkBl[Xm| NWfCXlRuT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hTFVzNEWgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClb3zvcpkh\m:{bXH0bY9vKGGodHXyJFEyKHSxIEGyJIRigXNiYomgZ5J6e3SjbDD2bY9t\XRic4ThbY5qdmdiYnHz[YQhdWmlcn;zZ49xcWNiYX7hcJl{cXNuIFnDOVA:OC55zszN MmryQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7MECyN|EoRjJ2OUCwNlMyRC:jPh?=
HeLa MlzURY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NX;H[mlkPzJiaILz NGr3N5lCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjlUIEh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1zLkVOwG0> NX7KSJJ[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NFAzOzFpPkK0PVAxOjNzPD;hQi=>
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DU145 MoO0SpVv[3Srb36gZZN{[Xl? NWjFWYlrODVidH:gNVAhfU1? MXeyJIhzew>? M2exV2lvcGmkaYTpc44hd2ZiU2TBWFMhcW62ZYLhZ5Rqd25id3n0bEBFVkFiYnnu[Ilv\yC|aYTlJIlvKGi3bXHuJGRWOTR3IHPlcIx{KGG2IEC1JJRwKDFyIIXNJIFnfGW{IEKgbJJ{KGK7IFXNV2E> MoHNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7MECyN|EoRjJ2OUCwNlMyRC:jPh?=
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T98G NEP1bG5CdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MormOUBl[Xm| MXfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFR7OFegZ4VtdHNiYX\0[ZIhPSCmYYnzJIJ6KEGuYX3hdmJtfWViYYPzZZktKEmFNUC9NE4{|ryP NXTR[npRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C1PFMzPDhpPkOwOVg{OjR6PD;hQi=>
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Jurkat M3TtOWN6fG:2b4jpZ4l1gSCjc4PhfS=> NI\2b3k{KGSjeYO= NWD6ZlB{S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUnW{a3H0JINmdGy|IHnuZ5Vj[XSnZDDmc5IhOyCmYYnzJIJ6KEOnbHzUbZRmei2JbH:gcJVucW6nc3PlcpQh[XO|YYmsJGlEPTB;MD60{txO Mli2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF{NUO1NlkoRjNzMkWzOVI6RC:jPh?=
NALM6 MoDZR5l1d3SxeHnjbZR6KGG|c3H5 NFfQ[ZQ{KGSjeYO= Mn7VR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUmFNVTZiY3XscJMhcW6ldXLheIVlKG[xcjCzJIRigXNiYomgR4VtdFSrdHXyMWdtdyCudX3pcoV{[2WwdDDhd5NigSxiSVO1NF0xNjZ{zszN MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTJ3M{WyPUc,OzF{NUO1Nlk9N2F-
HEK293 Ml:ySpVv[3Srb36gZZN{[Xl? Ml71PVAhdWmwcx?= MnLOTY5pcWKrdHnvckBw\iCNSWitVmx2[05iZoXz[YQhS0KSIDj1cotvd3ewIH;ybYdqdiliYnnu[Ilv\yC2bzDLTWQuWky3Y1Og[pV{\WRiQ2LFRkApfW6tbn;3ckBwemmpaX6pJJRz[W6|ZnXjeIVlKGmwIHj1cYFvKEiHS{K5N{Bk\WyuczDwdoVqdmO3YnH0[YQhf2m2aDDjc41xd3WwZDCzNEBucW6|IHLl[o9z\SCkZX\vdoUh\m:{c3vvcIlvKGGmZHn0bY9vKGGwZDDt[YF{fXKnZDDh[pRmeiB7MDDtbY5{KGmwIIDy[ZNmdmOnIH;mJINw\WynboTldoF7NCCLQ{WwQVEvPTQQvF2= MkTHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF{NUO1NlkoRjNzMkWzOVI6RC:jPh?=
293beta5 MV7BcpRqfmm{YXygZZN{[Xl? MVi3JIRigXN? M2HGZ2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHHk[Y5wfmm{dYOgOUBqdm[nY4Tl[EBqdiB{OUPi[ZRiPSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJBt[XG3ZTDmc5Ju[XSrb36gbY5kfWKjdHXkJIZweiB5IHThfZMh[nliR1\QJJJmeG:{dHXyJIdmdmViYYPzZZktKEmFNUC9NE43|ryP NHHJbXU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MkC0OVI{QSd-M{KwOFUzOzl:L3G+
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A549 M{S3VmN6fG:2b4jpZ4l1gSCjc4PhfS=> NHv3WmE1QCCqcoO= M3[2XWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCjbHHtZZIh[my3ZTDhd5NigSxiQ1O1NF0zOi57zszN MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OjB2NUKzPUc,OzJyNEWyN|k9N2F-
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skeletal myoblast cells Ml7VR5l1d3SxeHnjbZR6KGG|c3H5 NYD1[pJMPzJiaB?= MkWxSG5FUTpiQ4n0c5RwgGmlaYT5JIlvKF[rdILvMEA4OiCqb4XyMEBqdiC{YYSgd4tmdGW2YXygcZlw[myjc4SgZ4VtdHNuIFnDOVA:Oi5|zszN NX[ydHF[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTR2OD:nQmNpTU2ETEyvZV4>
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... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-STAT3 / STAT3 / c-Myc / Survivin ; 

PubMed: 25970160     


LNCaP, C4-2B or DU145 cells were treated with DMSO, 0.5 μM or 1 μM niclosamide overnight, cells were then stimulated with 10 ng/mL of IL6 for 30 minutes. Whole cell lysates were prepared and subjected to Western blot analysis using antibodies as indicated.

p-BCR-ABL / BCR-ABL ; 

PubMed: 29358661     


KBM5 cells harboring wild-type or T315I-BCR-ABL and K562 cell were exposed to different concentrations of niclosamide, and then analyzed by Western blotting analysis.

p-STAT5 / STAT5 / p-AKT / AKT / p-ERK / ERK ; 

PubMed: 29358661     


CML cells were treated with increasing concentrations of niclosamide for 48 h and subjected to Western blotting analysis. Actin served as a loading control for blots above, which were performed sequentially.

β-catenin; 

PubMed: 27652012     


Niclosamide decreases intracellular β-catenin levels in A-498 and SW-839 cells. Cells were treated with niclosamide for 24 h prior to WB analysis.

25970160 29358661 27652012
Growth inhibition assay
Cell viability; 

PubMed: 28418862     


Cell viability of colon cancer cells after treatment of niclosamide for a 48-h period. Cell viability was determined by trypan blue exclusion assay from triplicate experiments.

28418862
体内研究 在负荷HL-60异种移植瘤的小鼠体内,Niclosamide(40 mg/kg/d, i.p.)抑制异种移植的AML细胞生长。[4]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

- 合并

蛋白激酶性能测定:

对22中不同蛋白激酶的测定通过ProQinase Gmbh进行。所有蛋白激酶在Sf9昆虫细胞或大肠杆菌中以重组GST融合蛋白或组氨酸标记的蛋白质表达。蛋白激酶试验GSH-琼脂糖或Ni_NTH-琼脂糖通过亲和色谱法纯化。放射性蛋白激酶试验用于测量22种蛋白激酶的激酶活性。简而言之,对每种蛋白激酶,50 μL反应混合物包含60 mM HEPES-NaOH,3 mM MgCl2,3 mM MnCl2,3 μM 原矾酸钠,1.2 mM DTT,50 μg/mL PEG20000,1 μM [γ-33P]-ATP,Niclosamide,足量酶和其底物。另外PKC-α测定包含1 mM Cacl2, 4 mM EDTA,5 μg/mL 磷脂酰丝氨酸和1 μg/mL 1, 2-二油基-丙三醇。反应混合物在37 °C下培育60分钟,用50 μL 2% (v/v) H3PO4停止。33Pi的整合用微板闪烁计数器测定。活性和IC50值使用Quattro Workflow V2.28计算。
细胞实验:

[1]

- 合并
  • Cell lines: Hela,A549,Du145,HT-29,A431,PC3细胞
  • Concentrations: 16 μM
  • Incubation Time: 72小时
  • Method:

    将细胞以3-4 ×103细胞/孔的密度接种于96孔板,第二天加入包含不同浓度Niclosamide的100μL培养基处理。处理72小时后,将MTT加入每个孔,再培育4-5小时,吸光度在酶标仪上570nm下测量。细胞生长抑制以样品相对于对照组的吸光度比率评估。测定结果至少代表3个独立实验。


    (Only for Reference)
动物实验:

[4]

- 合并
  • Animal Models: 负荷 HL-60 异种移植瘤的裸鼠
  • Dosages: 40 mg/kg
  • Administration: 腹腔注射
    (Only for Reference)

溶解度 (25°C)

体外 DMF 12 mg/mL warmed (36.68 mM)
DMSO Insoluble
Water Insoluble

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 327.12
化学式

C13H8Cl2N2O4

CAS号 50-65-7
储存条件 粉状
溶于溶剂
别名 Niclocide, NSC 178296

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04436458 Not yet recruiting Drug: Niclosamide Oral Tablet|Drug: Placebo COVID First Wave Bio Inc. June 2021 Phase 2
NCT04644705 Recruiting Drug: Niclosamide|Drug: Placebo Healthy Volunteers Charité Research Organisation GmbH|Bayer November 2 2020 Phase 1
NCT04592835 Not yet recruiting Drug: DWRX2003 COVID-19 Patients Daewoong Pharmaceutical Co. LTD.|Novotech (Australia) Pty Limited October 19 2020 Phase 1
NCT04524052 Not yet recruiting Drug: DWRX2003|Drug: Placebo Healthy Daewoong Pharmaceutical Co. LTD. August 2020 Phase 1
NCT03521232 Recruiting Drug: Niclosamide Ulcerative Colitis|Ulcerative Proctitis|Ulcerative Proctosigmoiditis First Wave Bio Inc. May 15 2018 Phase 1|Phase 2
NCT02687009 Terminated Drug: Niclosamide Colon Cancer Michael Morse MD|Duke University November 7 2017 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID