Talazoparib (BMN 673)

For research use only. Not for use in humans.

目录号：S7048 别名： LT-673

Talazoparib (BMN 673) Chemical Structure

CAS No. 1207456-01-6

Talazoparib (BMN 673, LT-673)是一种新型的PARP抑制剂，无细胞试验中对PARP1的IC50为0.57 nM。它也是有效的PARP-2抑制剂，但不抑制PARG，对PTEN突变型高度敏感。Phase 3。

规格

价格

库存

购买数量

10mM (1mL in DMSO)	RMB 4005.46	现货
10mg	RMB 3831.14	现货
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客户使用Selleck生产的Talazoparib (BMN 673)发表文献142篇：

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Sci Rep, 2020, 10(1):14253

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Front Pharmacol, 2020, 11:610205

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Biochemistry, 2020, 10.1021/acs.biochem.0c00256

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JCI Insight, 2020, 142149

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Nat Biotechnol, 2020, 10.1038/s41587-020-0600-6

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Commun Biol, 2020, 3(1):388

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Am J Cancer Res, 2020, 10(2):648-661

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Transl Oncol, 2020, 13(11):100834

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Int J Cancer, 2020, 147(4):1059-1070

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Sci Signal, 2020, 13(645):eaba8091

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Mol Cell, 2020, 80(5):862-875.e6

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CU Digital Repository, 2020, N/A

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Oncotarget, 2020, 11(23):2141-2159

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BMC Cancer, 2020, 20(1):775

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Cell Rep, 2020, 32(5):107985

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Nat Commun, 2019, 10(1):2189

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Nat Commun, 2019, 10(1):2910

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J Clin Invest, 2019, 129(3):1211-1228

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Nat Chem Biol, 2019, 15(12):1223-1231

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Nat Commun, 2019, 10(1):2954

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Nucleic Acids Res, 2019, 47(11):5634-5647

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J Thorac Oncol, 2019, 14(10):1743-1752

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Clin Cancer Res, 2019, 10.1158/1078-0432

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EMBO Rep, 2019, 20(5)

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Cancer Res, 2019, 79(2):311-319

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J Med Chem, 2019, 62(11):5330-5357

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Cancers (Basel), 2019, 11(10)

PubMed: 31623402 ( click the link to review the publication )

Cancers (Basel), 2019, 11(12)

PubMed: 31810230 ( click the link to review the publication )

Cell Death Discov, 2019, 5:127

PubMed: 31396404 ( click the link to review the publication )

Cell Death Dis, 2019, 10(4):281

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Front Oncol, 2019, 9:353

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Cancer Immunol Res, 2019,

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Nat Commun, 2018, 9(1):2678

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Nat Commun, 2018, 9(1):3982

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EMBO J, 2018, 37(14)

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Clin Cancer Res, 2018, 24(7):1705-1715

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Cell Rep, 2018, 23(11):3127-3136

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Elife, 2018, 7

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Mol Cancer Ther, 2018, 17(9):1995-2003

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Am J Cancer Res, 2018, 8(9):1837-1846

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产品安全说明书

PARP抑制剂选择性比较

生物活性

产品描述

特性

到目前为止报道的最有效的选择性PARP抑制剂。

靶点

PARP1 ^[1]
(Cell-free assay)

0.57 nM

体外研究

BMN-673 选择性与PARP 结合，且抑制PARP-介导的通过碱基切除修复途径的单链DNA断裂的修复。增强了DNA链断裂的积累，促进基因组不稳定性，并最终导致细胞凋亡。BMN 673选择性杀死BRCA-1或BRCA-2突变的癌细胞。BMN 673作用于BRCA-1突变 (MX-1,IC50 = 0.3 nM) 和BRCA-2 突变的细胞(Capan-1,IC50 = 5 nM)，具有单药细胞毒性。相反, BMN-673 作用于MRC-5正常人类成纤维细胞和其他含野生型BRCA-1 和 BRCA-2基因的肿瘤细胞系，IC50为90 nM到1.9 μM。^[1] BMN 673 作用于培养的人类癌细胞，也显著增强Temozolomide 和 SN-38的细胞毒性效果。^[2]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
BR5FVB1-Akt	NXTme\|hQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnvkNE4yNTFyMDDuUS=>	NF7Sb\|EzPC92OD:3NkBp	M1\Qd4lvcGmkaYTzJINmdGxicILvcIln\XKjdHnvckBld3OnIHTldIVv\GWwdHz5	M4nxT\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MES3Olk4Lz5{NkC0O\|Y6PzxxYU6=
BR5FVB1-Akt	MmX2RZBweHSxc3nzJGF{e2G7	MWmwMlEuOTByIH7N	NGSzXW84OiCq	M1fSS4lv\HWlZYOgZZBweHSxc3nz	MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjB2N{[5O{c,OjZyNEe2PVc9N2F-
Capan-1	NVHmZnd{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NXG0VnFqUUN3ME2xOk4x6oDLwsJihKk2NjUkgJpCuW3DqA>?	M335U\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OE[0OVkxLz5{NUi2OFU6ODxxYU6=
MIA PaCa-2	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MV3JR\|UxRTV6LkKz5qCKyrIkgJm4MlHjiIoEtV5CpC=>	NGrndHo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi2OFU6OCd-MkW4OlQ2QTB:L3G+
RD	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MULJR\|UxRThwNzDuUS=>	M3:0eFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Mk[zOVM6Lz5{NUK2N\|U{QTxxYU6=
Rh41	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			M13URmlEPTB;OD6xJI5O	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTJ4M{WzPUc,OjV{NkO1N\|k9N2F-
Rh18	MkThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MXHJR\|UxRTRwOTDuUS=>	NFHNWoM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUK2N\|U{QSd-MkWyOlM2Ozl:L3G+
Rh30	NYjuW29YT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M3;2OWlEPTB;M{GuNUBvVQ>?	M13lS\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Mk[zOVM6Lz5{NUK2N\|U{QTxxYU6=
BT-12	M37GfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MoPXTWM2OD8kgJmxMFAxOCCwTR?=	NYD3ZXhwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyOlM2OzlpPkK1NlY{PTN7PD;hQi=>
CHLA-266	M4D0NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M{TpZmlEPTB-4pEJNUwxODBibl2=	MnywQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{NkO1N\|koRjJ3Mk[zOVM6RC:jPh?=
TC-71	M{\KeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M4jE[WlEPTB;Mz63JI5O	MnXVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{NkO1N\|koRjJ3Mk[zOVM6RC:jPh?=
CHLA-9	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NUDNSG5LUUN3ME24MlIhdk1?	Mn;ZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{NkO1N\|koRjJ3Mk[zOVM6RC:jPh?=
CHLA-10	NHzWb2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M1ntXmlEPTB;NkeuPEBvVQ>?	NWq0PYxxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyOlM2OzlpPkK1NlY{PTN7PD;hQi=>
CHLA-258	M13q[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NWey[G1wUUN3ME20MlYhdk1?	NIfzUpo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUK2N\|U{QSd-MkWyOlM2Ozl:L3G+
SJ-GBM2	NETqeYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			Mn\nTWM2OD1zNj6yJI5O	NHyxb\|A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUK2N\|U{QSd-MkWyOlM2Ozl:L3G+
NB-1643	M2TlUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M1X5NmlEPTB;MUiuOEBvVQ>?	NUDL[WQ5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyOlM2OzlpPkK1NlY{PTN7PD;hQi=>
NB-EBc1	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NHfZV5VKSzVyPUK1Mlghdk1?	NV;pWXB3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyOlM2OzlpPkK1NlY{PTN7PD;hQi=>
CHLA-90	NYmzZ5VwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MnPTTWM2OD8kgJmxMFAxOCCwTR?=	NW\VZ4pZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyOlM2OzlpPkK1NlY{PTN7PD;hQi=>
CHLA-136	MmnTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NWnBUIdpUUN3ME2xOE4zKG6P	MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTJ4M{WzPUc,OjV{NkO1N\|k9N2F-
NALM-6	NIW0[VFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			Mmf2TWM2OD12OTDuUS=>	MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTJ4M{WzPUc,OjV{NkO1N\|k9N2F-
COG-LL-317	M1z0OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NXzv[oFqUUN3ME25MlQhdk1?	MoX4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{NkO1N\|koRjJ3Mk[zOVM6RC:jPh?=
RS4;11	NUDybVM2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NEHNZlBKSzVyPUWyMlYhdk1?	NYPKWIhHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyOlM2OzlpPkK1NlY{PTN7PD;hQi=>
MOLT-4	NX\YcYZmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NVjtW5FjUUN3ME2xOk43KG6P	NFiyPWs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUK2N\|U{QSd-MkWyOlM2Ozl:L3G+
CCRF-CEM	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NITLPHhKSzVyPU[5O{4{KG6P	NWHwOoN2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyOlM2OzlpPkK1NlY{PTN7PD;hQi=>
Kasumi-1	NULzcJdTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MX\JR\|UxRTd6Nj6yJI5O	MoHtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{NkO1N\|koRjJ3Mk[zOVM6RC:jPh?=
Karpas-299	NITWSHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M1;FfmlEPTB;N{WuO{BvVQ>?	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTJ4M{WzPUc,OjV{NkO1N\|k9N2F-
Ramos-RA1	NFrvS\|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NGTzWWRKSzVyPU[4MlMhdk1?	M1;Y[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Mk[zOVM6Lz5{NUK2N\|U{QTxxYU6=
DT40	NFPNUGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M2HETmlEPTB;NDDuUS=>	NXu4[nBLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzOVY5OTNpPkK0N\|U3QDF\|PD;hQi=>
DU145	Mn3OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NH:zNnNKSzVyPUGxJI5O	NXz1Z4V2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzOVY5OTNpPkK0N\|U3QDF\|PD;hQi=>
H209	NYrucnlMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NIj3c2RKSzVyPUGuO{BvVQ>?	MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB5N{O1NEc,OjRyN{ezOVA9N2F-
H1048	M4Phdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NYXh[Is6UUN3ME2yMlIhdk1?	MkDEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyN{ezOVAoRjJ2MEe3N\|UxRC:jPh?=
H524	MmTKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			M2T4SmlEPTB;Mz6xJI5O	NVe2e5M6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwO\|c{PTBpPkK0NFc4OzVyPD;hQi=>
H1930	MoD5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NWTsZotkUUN3ME20MlEhdk1?	NYXDcYJIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwO\|c{PTBpPkK0NFc4OzVyPD;hQi=>
H69	NIH6UFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M2LxZ2lEPTB;NT6yJI5O	M4TYd\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEe3N\|UxLz5{NEC3O\|M2ODxxYU6=
H2081	NXXaT4gyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NGXzNWpKSzVyPU[uN{BvVQ>?	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB5N{O1NEc,OjRyN{ezOVA9N2F-
H2107	M4X0[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MnHHTWM2OD15LkOgcm0>	NI\HWnQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC3O\|M2OCd-MkSwO\|c{PTB:L3G+
H1092	MkjKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NHXQRnNKSzVyPUiuPUBvVQ>?	NIXCPJc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC3O\|M2OCd-MkSwO\|c{PTB:L3G+
DMS-79	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NF\EXlhKSzVyPUmuN{BvVQ>?	NGrQWlg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC3O\|M2OCd-MkSwO\|c{PTB:L3G+
H446	M4L3cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MmHiTWM2OD1zMzDuUS=>	MnnoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyN{ezOVAoRjJ2MEe3N\|UxRC:jPh?=
COR-L279	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MVzJR\|UxRTF3IH7N	M3nCN\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEe3N\|UxLz5{NEC3O\|M2ODxxYU6=
LoVo	NY\QcGh6TnWwY4Tpc44h[XO\|YYm=		MmDaN\|AhdWmwcx?=	MkDMSWM2OCB;IECuNFAzPSEQvF2=	NEPlNWs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe2NVA6Pid-MkW3OlExQTZ:L3G+
MX1	NHG0ZmREgXSxdH;4bYNqfHliYYPzZZk>			M2fxTWVEPTBiPTCwMlAxODNizszN	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjZ3MkexO{c,OjZ4NUK3NVc9N2F-
LoVo	NGP1[ZVHfW6ldHnvckBie3OjeR?=		NIfyRWY{OCCvaX7z	NF23W2NGSzVyIE2gNE4xODJ3MTFOwG0>	NUXSNm1ORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[2OVI4OTdpPkK2OlUzPzF5PD;hQi=>
LoVo	M1Tq[mN6fG:2b4jpZ4l1gSCjc4PhfS=>	NXzWNotmOC52IIXN	MnPkOUBl[Xm\|	MWjHTVUxKD1iMD6wNFQh\|ryP	NX7JPHpQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[2OVI4OTdpPkK2OlUzPzF5PD;hQi=>
Capan1	NHvnVGdEgXSxdH;4bYNqfHliYYPzZZk>			NXzNUlJuTUN3MDC9JFAvODB3IN88US=>	NUDzTZhCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[2OVI4OTdpPkK2OlUzPzF5PD;hQi=>
MRC5	Mnn0R5l1d3SxeHnjbZR6KGG\|c3H5			NIXOfFhGSzVyIE2gNE4{OSEQvF2=	NH\xeVk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nk[1NlcyPyd-Mk[2OVI4OTd:L3G+
MX1	Moi1SpVv[3Srb36gZZN{[Xl?	NEXjSIgyKG2pL3vn	NUiyR3VrOiBuODDhcoQhOjRiaILz	MULE[YNz\WG\|ZTDpckBRSVJibHX2[YwhcW5iYYTofY1q[yCwdT;ueUBud3W\|ZTD4[Y5w\3KjZoTl[EB4cXSqIHj1cYFvKE2[MTDj[YxteyCjdDCxJI1oN2upLDDwc{Bi\G2rbnnzeIVz\WRiYYOgd4lv\2ynIHTvd4UhdWWjc4Xy[YQh[W[2ZYKgNkAtQCCjbnSgNlQhcHK\|IHL5JGVNUVOD	NEP6U4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nk[1NlcyPyd-Mk[2OVI4OTd:L3G+
MX1	M4e5TmFvfGm2dX3vdkBie3OjeR?=	NVPzTmVJOC5\|MzDt[{9s\w>?	NIXxSIczQCCmYYnz	NYHpOIxESW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhSlKFQUGg[IVncWOrZX70JIh2dWGwIF3YNUBk\WyuczD4[Y5w\3KjZoTl[EBqdiCjdHj5cYlkKG63L371JI1wfXOnIHH0JFAvOzNibXevb4ctKHCxIIHkJIFldWmwaYP0[ZJm\CCob4KgNlgh\GG7cx?=	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjZ3MkexO{c,OjZ4NUK3NVc9N2F-
MX1	MWPBcpRqfHWvb4KgZZN{[Xl?	NHvrfmwxNjF4NTDt[{9s\w>?	M4[3SlI5KGSjeYO=	MmTnRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgRnJESTFiZHXmbYNq\W62IHj1cYFvKE2[MTDj[YxteyC6ZX7v[5Ji\nSnZDDpckBifGi7bXnjJI52N263IH3veZNmKGG\|c3Xzd4VlKGG\|IIT1cY9zKGe{b4f0bEBqdmirYnn0bY9vKGG2IECuNVY2KG2pL3vnMEBxdyCjZH3pcol{fGW{ZXSgeJdq[2ViYTDkZZkh\m:{IEK4JIRigXN?	NHHDS4E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nk[1NlcyPyd-Mk[2OVI4OTd:L3G+
MX1	M1uzb2Z2dmO2aX;uJIF{e2G7	Mlq4NE4{OyCvZz;r[y=>		Mor1VI91\W62aXH0bY9vKG:oIHPhdoJweGyjdHnuMYlv\HWlZXSgeJVud3JiZ4Lve5RpKGmwaHnibZRqd25ib3[gRnJESTFiZHXmbYNq\W62IHj1cYFvKE2[MTDj[YxteyC6ZX7v[5Ji\nSnZDDpckBifGi7bXnjJI52N263IH3veZNmKGG2IECuN\|MhdWdxa3egdI8h[W6mIHHubY1idHNid3Xy[UB1emWjdHXkJJdqfGhiY3HyZo9xdGG2aX6gZZQhOzVibXevb4ctKGmyIH;uJIRigSBz	Mmq0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ4NUK3NVcoRjJ4NkWyO\|E4RC:jPh?=
MDA-MB-436	NWK5VJN1SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MmPCO{Bl[Xm\|	NVvlSIpqUUN3MDC9JFAvODByNzFOwG0>	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDZ7MkmxOkc,Ojh4OUK5NVY9N2F-
Capan1	NX7Rco1DSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NE\wS2g4KGSjeYO=	MVPJR\|UxKD1iMD6wNFE5KM7:TR?=	M{HPZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NkmyPVE3Lz5{OE[5NlkyPjxxYU6=
VC8	Ml\5R5l1d3SxeHnjbZR6KGG\|c3H5		M{K1N\|Mh\GG7cx?=	M3rjTmlEPTBiPTCwMlAxPDJizszN	M1HNUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NkmyPVE3Lz5{OE[5NlkyPjxxYU6=
V79	NXfrb4dNS3m2b4TvfIlkcXS7IHHzd4F6		MXezJIRigXN?	MWrJR\|UxKD1iNT6wNVE1KM7:TR?=	NYnQUVhlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2PVI6OTZpPkK4OlkzQTF4PD;hQi=>
Capan1	MWfGeY5kfGmxbjDhd5NigQ>?	NUHKd3o5OC5zIIXN	M1nYOFQhcHK\|	MlzhTY5pcWKrdHnvckBw\iCSQWLQNUBqdiCEUlPBNkBl\W[rY3nlcpQhcHWvYX6gR4Fx[W5zIHPlcIx{KGG\|c3Xzd4VlKGG\|IHnuZ5Jm[XOnIHnuJHBCWlBzLVTORUB1emGycHnu[{BifCByLkGgeW0h[W[2ZYKgOEBpenNiYomgW4V{fGW{bjDicI91KGGwYXz5d4l{	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDZ7MkmxOkc,Ojh4OUK5NVY9N2F-
MDA-MB-436	MWfGeY5kfGmxbjDhd5NigQ>?	M1HtfFEhfU1?	NYq0VWx7PCCqcoO=	NWjISmVyUW6qaXLpeIlwdiCxZjDQRXJROSCrbjDCVmNCOSCmZX\pZ4lmdnRiaIXtZY4hVUSDLV3CMVQ{PiClZXzsd{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDQRXJROS2GTlGgeJJieHCrbnegZZQhOSC3TTDh[pRmeiB2IHjyd{BjgSCZZYP0[ZJvKGKub4SgZY5idHm\|aYO=	M4HzeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NkmyPVE3Lz5{OE[5NlkyPjxxYU6=

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	cleaved-PARP / cleaved-caspase3 / γ-H2AX; PubMed: 29158830 Theranostics Western Blot data testing protein expression after treatment with Olaparib, Niraparib, and Talazoparib on Brca1-deficient cell line in W0069 cells. pKAP1 / pChk2 / pChk1; PubMed: 28947502 Mol Cancer Ther Western blot images (representative from 3 independent experiments) showing the impact of a 24 hour pre-treatment with TAL ± TMZ on DNA damage signaling in U251 (MGMT-low) and T98G (MGMT-high) cells. PD-L1; PubMed: 28167507 Clin Cancer Res MDA-MDA-MB-231 and BT549 cells were treated with 10 μM olaparib or 10 nM talazoparib for 24 hours, and subjected to immunoblotting with the indicated antibodies. PD-L1 knockout (K/O) cells were included as a negative control. p-ATM; PubMed: 30472087 EBioMedicine Western blot analysis of the DNA damage sensors ATM, p-ATM (Ser1981), CHK1, p-CHK1 (Ser317), CHK2 and p-CHK2 (Thr68) in MV4-11 and HL-60 cells. GAPDH served as a loading control.	29158830 28947502 28167507 30472087
Growth inhibition assay	Cell viability; PubMed: 29158830 Theranostics Measured dose response curve and IC50 of Talazoparib in W780 and W0069 cells.	29158830
Immunofluorescence	cleaved PARP / 53BP1; PubMed: 28958991 Mol Cancer Ther Cleaved-PARP and 53BP1 expression. Representative images with 10× objective from high-content imaging of control cells in the left column, and cells treated with veliparib, olaparib, and talazoparib in three right columns. 53BP1 expression is seen in: A, HCC1143; B, MDAMB231; and C, HCC1806. Blue represents nuclear staining and pink foci represent 53BP1 foci. Cleaved-PARP expression is seen in D, HCC1143 and E, HCC1806. Blue represents nuclear staining and green represents cleaved-PARP expression. RAD51; PubMed: 30621214 Cancers (Basel) (A) MCF7 and (B) MCF7-T cells were treated with either 100 nM tamoxifen (Tamox) or 1 nM talazoparib (Talaz) for 72 h, alone and in combination. 24 h post treatment RAD51 foci formation assay was performed. Scale bar: 20 µm.	28958991 30621214

体内研究

在大鼠的药代动力学研究中，BMN673每天单独给药，具有>50％口服生物有效性和药代动力学特性。在MX-1移植瘤肿瘤模型研究中, BMN 673每天口服给药，显著增强细胞毒性疗法的抗肿瘤效果，这种作用具有剂量依赖性。^[2]

动物实验： ^[2]	- 合并 Animal Models: MX-1模型(BRCA-1缺陷的) Dosages: 0.33 mg/kg/day,每天一次 Administration: 口服处理 (Only for Reference)

参考文献

溶解度 (25°C)

体外	DMSO	38 mg/mL warmed (99.9 mM)
	Water	Insoluble
	Ethanol	Insoluble

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量	380.35
化学式	C₁₉H₁₄F₂N₆O
CAS号	1207456-01-6
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	LT-673

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

临床试验信息 (data from https://clinicaltrials.gov, updated on 2021-09-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04987931	Not yet recruiting	Drug: Talazoparib	Breast Cancer	Pfizer	August 10 2021	--
NCT04991480	Not yet recruiting	Drug: ART4215\|Drug: Talazoparib	Advanced Cancer\|Metastatic Cancer\|Breast Cancer	Artios Pharma Ltd	August 2021	Phase 1\|Phase 2
NCT04901702	Recruiting	Drug: Onivyde\|Drug: Talazoparib\|Drug: Temozolomide	Recurrent Solid Tumor\|Recurrent Ewing Sarcoma\|Recurrent Hepatoblastoma\|Recurrent Malignant Germ Cell Tumor\|Recurrent Malignant Solid Neoplasm\|Recurrent Neuroblastoma\|Recurrent Osteosarcoma\|Recurrent Peripheral Primitive Neuroectodermal Tumor\|Recurrent Rhabdoid Tumor\|Recurrent Rhabdomyosarcoma\|Recurrent Soft Tissue Sarcoma\|Recurrent Wilms Tumor\|Refractory Ewing Sarcoma\|Refractory Hepatoblastoma\|Refractory Malignant Germ Cell Tumor\|Refractory Malignant Solid Neoplasm\|Refractory Neuroblastoma\|Refractory Osteosarcoma\|Refractory Peripheral Primitive Neuroectodermal Tumor\|Refractory Rhabdoid Tumor\|Refractory Rhabdomyosarcoma\|Refractory Soft Tissue Sarcoma	St. Jude Children''s Research Hospital\|Pfizer\|Ipsen	June 9 2021	Phase 1\|Phase 2
NCT04703920	Recruiting	Drug: Talazoparib\|Drug: Belinostat	Metastatic Breast Cancer\|Metastatic Castration-resistant Prostate Cancer\|Metastatic Ovarian Carcinoma	University of Michigan Rogel Cancer Center\|Pfizer\|Acrotech Biopharma LLC	March 4 2021	Phase 1
NCT04672460	Recruiting	Drug: TALZENNA capsule\|Drug: Talazoparib soft gel capsule	Advanced Solid Tumors	Pfizer	December 21 2020	Phase 1

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

常见问题及建议解决方法

问题 1：
Which solvent do you recommend to dilute the inhibitor for in vivo study in mice?
回答：
BMN673 (S7048) can be dissolved in vehicle (10% DMAc, 6% Solutol, and 84% PBS) according to the paper: http://clincancerres.aacrjournals.org/content/19/18/5003.full. Quote from Method and Material section "Xenograft experiments: BMN 673 (various doses as indicated), or vehicle (10% DMAc, 6% Solutol, and 84% PBS) was administered by oral gavage"

PARP Signaling Pathway Map

PARP Inhibitors with Unique Features

选择性强的PARP抑制剂

AG-14361 : PARP1-selective, K_i<5 nM.
活性最高的PARP抑制剂

MK-4827 (Niraparib) : PARP1, IC50=3.8 nM; PARP2, IC50=2.1 nM.
用于临床的PARP抑制剂

Iniparib (BSI-201) : Phase III for solid tumors.

研究领域

产品类型

定制您的化合物库

Talazoparib (BMN 673)

客户使用Selleck生产的Talazoparib (BMN 673)发表文献142篇：

产品安全说明书

PARP抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

临床试验信息 (data from https://clinicaltrials.gov, updated on 2021-09-06)

技术支持

常见问题及建议解决方法

PARP Signaling Pathway Map

PARP Inhibitors with Unique Features

相关PARP产品