PF-04929113 (SNX-5422)
For research use only. Not for use in humans.
目录号:S2656

CAS No. 908115-27-5
PF-04929113 (SNX-5422)是一种有效的,选择性的HSP90抑制剂,Kd为41 nM,且诱导Her-2降解,IC50为37 nM。Phase 1/2。
客户使用Selleck生产的PF-04929113 (SNX-5422)发表文献4篇:
客户使用该产品的3个实验数据:
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Effect of SNX-2112 on E. histolytica morphology. Trophozoites were treated with 3 uM SNX-2112 for 48 h. (A) E. histolytica trophozoites treated with 0.5% DMSO. Arrow indicates live trophozoite. Magnification, x 10. (B) E. histolytica trophozoites treated with 3 uM SNX-2112. Treatment caused complete lysis of trophozoites (arrow). Magnification, x 10. Trophozoites were imaged under phase-contrast microscope.
Antimicrob Agents Chemother 2014 58(7), 4138-44. PF-04929113 (SNX-5422) purchased from Selleck.
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8505C and CAL62 cells were treated with SNX5422 at 5 μM for 72 h, and the protein levels of hsp90, hsp70, Raf-1, GSK3b, and total and phospho-Akt were measured. All experiments were performed in triplicate. The blots are representative of independent experiments.
Endocrine, 2016, 51(2):274-82.. PF-04929113 (SNX-5422) purchased from Selleck.
产品安全说明书
HSP (HSP90)抑制剂选择性比较
生物活性
产品描述 | PF-04929113 (SNX-5422)是一种有效的,选择性的HSP90抑制剂,Kd为41 nM,且诱导Her-2降解,IC50为37 nM。Phase 1/2。 | |||||
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靶点 |
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体外研究 |
PF-04929113是小分子Hsp90抑制剂。PF-04929113转化为SNX-2122起作用, SNX-2122是 Hsp90抑制剂的活性形式。PF-04929113有效作用于Her-2 稳定性,也引起Hsp70上调。PF-04929113作用于一系列癌细胞类型,具有有效的抗增殖活性。MCF-7(IC50=16 nM), SW620(IC50=19 nM), K562(IC50=23 nM), SK-MEL-5(IC50=25 nM), 及 A375(IC50=51 nM)。[1] |
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Assay |
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