Luminespib (AUY-922, NVP-AUY922)

目录号:S1069 别名: VER-52296

Luminespib (AUY-922, NVP-AUY922) Chemical Structure

Molecular Weight(MW): 465.54

Luminespib (AUY-922, NVP-AUY922)是一种高效的HSP90抑制剂,无细胞试验中作用于HSP90α/βIC50为13 nM /21 nM,对HSP90家族成员GRP94和TRAP-1具有稍弱的作用,与任何小分子HSP90配体均可紧密结合。Phase 2。

规格 价格 库存 购买数量  
RMB 2620.46 现货
RMB 1303.22 现货
RMB 2216.44 现货
RMB 3853.15 现货
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客户使用该产品的3个实验数据:

  • U2OS_exo cells were incubated with AUY922 for 20 h at the indicated concentrations before stimulation with TNFα (30 ng/mL) for 30 min and immunostaining to detect NF-κB (p65). DMSO 1%, cells stimulated by TNFα in the absence of AUY922. Representative pictures used to quantify nuclear and cytoplasmic localization of NF-κB.

    Proc Natl Acad Sci USA, 2014, 111(15): E1528–37 . Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

    J Biol Chem 2013 288(23), 16308-20. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

  • Western blots show the molecular signature of HSP90 inhibition by NVP-AUY922  (ie, induction of HSP72 and depletion of client proteins such as ERBB2, CRAF and CDK4) in BT474 breast cancer cell line. GAPDH was used as loading control.

     

     

    2011 Dr. Swee Sharp and Professor Paul Workman from Cancer Research UK. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

产品安全说明书

HSP (e.g. HSP90)抑制剂选择性比较

生物活性

产品描述 Luminespib (AUY-922, NVP-AUY922)是一种高效的HSP90抑制剂,无细胞试验中作用于HSP90α/βIC50为13 nM /21 nM,对HSP90家族成员GRP94和TRAP-1具有稍弱的作用,与任何小分子HSP90配体均可紧密结合。Phase 2。
靶点
HSP90α [1]
(Cell-free assay)
HSP90β [1]
(Cell-free assay)
13 nM 21 nM
体外研究

体外研究时NVP-AUY922抑制多种人类肿瘤细胞系的增殖,GI50平均值为9 nM。NVP-AUY922作用于胃癌细胞时IC50值为2到40 nM。NVP-AUY922作用于BEAS-2B细胞IC50为28.49 nM。使用NVP-AUY922时不影响HSP90的表达,但是提高HSP70的表达。NVP-AUY922增强HSP70与HSP90的结合能力。NVP-AUY922造成p23与HSP复合体的分离。NVP-AUY922能使HSP70结合到HSP90复合体。使用NVP-AUY922,引起酪氨酸激酶受体如VEGFR1, 2, 3和PDGFR-ɑ的表达下降,Akt和p-Akt也下降。另外,NVP-AUY922作用于NCI-N87细胞,引起HER2表达下降。NVP-AUY922提高HSP90与目标蛋白的结合力,然后通过蛋白酶使蛋白降解。NVP-AUY922可以改变多条信号通路而影响细胞生长。此外,使用蛋白酶抑制剂MG132,恢复由于使用NVP-AUY922而降低的胸核苷酸合酶的重新表达。[1]NVP-AUY922提高cleaved caspase-3的表达,及导致HSC-2 细胞凋亡。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CMK MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwMECwNVI2KM7:TR?= MkTzV2FPT0WU
MV-4-11 M3HjVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vNWWlEPTB;MD6wNFA2PThizszN M1X4NnNCVkeHUh?=
NALM-6 M3HCNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3v1[2lEPTB;MD6wNFA5PDJizszN NFLR[GhUSU6JRWK=
HOS NVexfmZ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NImxZ2FKSzVyPUCuNFAyOzhizszN M{LiU3NCVkeHUh?=
HT-144 NHrDUGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXraSlJ{UUN3ME2wMlAxOTV3IN88US=> NWTFXoFyW0GQR1XS
SW1710 NFzZVFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFe3bJNKSzVyPUCuNFAyQDZizszN M3LCOHNCVkeHUh?=
TE-8 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTBwMECyN|ch|ryP MmnkV2FPT0WU
ES1 MmHkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\SSWlEPTB;MD6wNFI3PiEQvF2= NX3hUm1rW0GQR1XS
CCF-STTG1 MnX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvITWM2OD1yLkCwNlk4KM7:TR?= MWDTRW5ITVJ?
PSN1 NVPpZpY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{Do[2lEPTB;MD6wNFMyQCEQvF2= NYXaV2NjW0GQR1XS
CAL-51 MkHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHL3UI9KSzVyPUCuNFA{OjVizszN NHXyNZJUSU6JRWK=
MCF7 NX[3Npg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDZUHRKSzVyPUCuNFA{OzVizszN NUDWSGw{W0GQR1XS
SK-HEP-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTBwMECzN|Yh|ryP NXG1V5FvW0GQR1XS
LCLC-103H NHfONnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33XNWlEPTB;MD6wNFQ{KM7:TR?= M4PsXnNCVkeHUh?=
HMV-II MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTBwMEC0OFkh|ryP MkLUV2FPT0WU
MES-SA MnfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3:zWWlEPTB;MD6wNFQ2OiEQvF2= NUD1SoZOW0GQR1XS
SK-LMS-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHVTWM2OD1yLkCwOFU5KM7:TR?= MkS2V2FPT0WU
639-V MlfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPTXoNKSzVyPUCuNFA1QDVizszN NHjTfHFUSU6JRWK=
SIG-M5 NGDudWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnOzTWM2OD1yLkCwOFg6KM7:TR?= M{e0SnNCVkeHUh?=
LOUCY MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnDTWM2OD1yLkCwOVA2KM7:TR?= NVXqU2FuW0GQR1XS
HSC-2 NXS5bGw6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlmxTWM2OD1yLkCwOVE5KM7:TR?= NXrkO441W0GQR1XS
EW-13 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGH4eYJKSzVyPUCuNFA2OThizszN NXzOcGpOW0GQR1XS
RT-112 NU\QdnZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XlNmlEPTB;MD6wNFU{PSEQvF2= NFvmeW5USU6JRWK=
NKM-1 NEfwOpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTGTWM2OD1yLkCwOVQ4KM7:TR?= NYfQcHR3W0GQR1XS
KYSE-180 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEi1doFKSzVyPUCuNFA2QDZizszN NGfTTXpUSU6JRWK=
SW1783 M3vJSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NISxSIFKSzVyPUCuNFA2QTFizszN NGXWWG5USU6JRWK=
A431 NHnxfHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwMEC2NFch|ryP MoD0V2FPT0WU
SK-OV-3 NGfJO4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHsTWM2OD1yLkCwOlMh|ryP MlTLV2FPT0WU
RPMI-7951 M3vyZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn:2TWM2OD1yLkCwOlMyKM7:TR?= NFn6bodUSU6JRWK=
Capan-2 NED6c|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTBwMEC2N|gh|ryP MnXwV2FPT0WU
HSC-3 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvXTWM2OD1yLkCwOlQyKM7:TR?= NEmzS|VUSU6JRWK=
786-0 M1;pXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;Sb2lEPTB;MD6wNFY3OyEQvF2= NFHGc25USU6JRWK=
Daoy MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGO5SGpKSzVyPUCuNFA3QTVizszN M{LTVXNCVkeHUh?=
KGN M1HTN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGf3UndKSzVyPUCuNFA4ODNizszN NVrzZVd2W0GQR1XS
EW-16 NH;SXnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4riN2lEPTB;MD6wNFc1QSEQvF2= NYPhXnhmW0GQR1XS
EW-7 NXvCd5p1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rJZmlEPTB;MD6wNFc2PCEQvF2= MYHTRW5ITVJ?
IGROV-1 MkPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HKWWlEPTB;MD6wNFgyPCEQvF2= NV[zWXZyW0GQR1XS
8505C NV[3eJBOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV2wU5RvUUN3ME2wMlAxQDJzIN88US=> M4GyV3NCVkeHUh?=
RKO NV;YdYc5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzzVlE4UUN3ME2wMlAxQDJ4IN88US=> MWfTRW5ITVJ?
GDM-1 NVnPSFVtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTWUYJuUUN3ME2wMlAxQDRizszN M{HOT3NCVkeHUh?=
IST-MEL1 NY\XXoJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LRfGlEPTB;MD6wNFg2OiEQvF2= M3;5[3NCVkeHUh?=
RPMI-6666 NYOwfHM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwMEC4OVIh|ryP MmPuV2FPT0WU
SNG-M MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPaZpdKSzVyPUCuNFA5PTZizszN M4jqT3NCVkeHUh?=
KS-1 NInNRWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILRXYhKSzVyPUCuNFA5PTlizszN NV7sV2lsW0GQR1XS
RXF393 NWjuZ25mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;YTWM2OD1yLkCwPFYh|ryP MULTRW5ITVJ?
CAL-12T NV:0O5B[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGD6V5hKSzVyPUCuNFA6OjJizszN NXzFUoY{W0GQR1XS
BFTC-905 M3TrN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwMEC5N|gh|ryP MY\TRW5ITVJ?
SK-MES-1 NUnj[48zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkWxTWM2OD1yLkCwPVQ2KM7:TR?= MmXkV2FPT0WU
BB30-HNC NWTucJV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;LOIlKSzVyPUCuNFA6PTJizszN NFrnZVBUSU6JRWK=
AN3-CA M2DMc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3v5dmlEPTB;MD6wNVAyPyEQvF2= MYfTRW5ITVJ?
EFO-27 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPac3FtUUN3ME2wMlAyODF5IN88US=> M3XydnNCVkeHUh?=
G-401 MkfZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTlO|dKSzVyPUCuNFExOjVizszN MV3TRW5ITVJ?
BPH-1 M3mySGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTyTWM2OD1yLkCxNFMh|ryP MY\TRW5ITVJ?
NCI-H727 NHPlXW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLIXWdKSzVyPUCuNFExOyEQvF2= NUixUpp2W0GQR1XS
SNU-423 NVX6fYt{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXrXnFTUUN3ME2wMlAyODV|IN88US=> NUn0dYF1W0GQR1XS
KYSE-270 M1:2TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnP1TWM2OD1yLkCxNFU6KM7:TR?= NFvYbnBUSU6JRWK=
AGS Ml2xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPFTWM2OD1yLkCxNFYyKM7:TR?= NYT6Z5Q1W0GQR1XS
NCI-H2228 NUKwVXdoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwMEGwOlQh|ryP NF30SYJUSU6JRWK=
SW954 NV3pVJhNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HpcGlEPTB;MD6wNVA4OSEQvF2= MV\TRW5ITVJ?
769-P MmT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwMEGwO|Mh|ryP M17KfnNCVkeHUh?=
BB49-HNC MlTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjvTWM2OD1yLkCxNFc4KM7:TR?= M3fKXnNCVkeHUh?=
IA-LM M3LIRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTBwMEGwPFYh|ryP Mkn4V2FPT0WU
NB69 M2SzfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX75XYxkUUN3ME2wMlAyOTB{IN88US=> MVjTRW5ITVJ?
C8166 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTBwMEGxNlkh|ryP MYHTRW5ITVJ?
NCI-H1299 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXQ[ZhKSzVyPUCuNFEyPTRizszN NFS2WGZUSU6JRWK=
YKG-1 M3v4e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTCTWM2OD1yLkCxNVYh|ryP NX7x[mNoW0GQR1XS
PANC-03-27 NHvxS49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rqbGlEPTB;MD6wNVE3OiEQvF2= NWLRUZByW0GQR1XS
YT NI\IVlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTBwMEGxO|kh|ryP M4TjOnNCVkeHUh?=
CAL-85-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIT4NFFKSzVyPUCuNFEyQTJizszN MXjTRW5ITVJ?
GT3TKB MnvSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\oTWM2OD1yLkCxNlAzKM7:TR?= M4L1bXNCVkeHUh?=
BB65-RCC M1rVU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljwTWM2OD1yLkCxNlA1KM7:TR?= NF3teItUSU6JRWK=
ES6 NFiybWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnENI1KSzVyPUCuNFEzPjFizszN MlfnV2FPT0WU
MHH-ES-1 NGLXfmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M136SmlEPTB;MD6wNVI3OyEQvF2= NVTtU5h6W0GQR1XS
QIMR-WIL M3vuXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfJTWM2OD1yLkCxNlY6KM7:TR?= M{K1NXNCVkeHUh?=
SNU-C2B MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrHTWM2OD1yLkCxNlczKM7:TR?= NEfqWoJUSU6JRWK=
OCI-AML2 NWD4W45FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHS4dXVKSzVyPUCuNFEzQDFizszN NX;Mc5F{W0GQR1XS
DU-145 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIC0PWhKSzVyPUCuNFEzQSEQvF2= NVXxdpVbW0GQR1XS
SW982 MlPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonPTWM2OD1yLkCxNlk{KM7:TR?= M2TmO3NCVkeHUh?=
MFH-ino M4DaVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zpXGlEPTB;MD6wNVI6OyEQvF2= NX2xU3dKW0GQR1XS
A427 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;1PXpKSzVyPUCuNFEzQTlizszN Mn3zV2FPT0WU
LCLC-97TM1 NWTjN2Q3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXHN4NKSzVyPUCuNFE{KM7:TR?= M2DLZ3NCVkeHUh?=
AM-38 MmG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXziZ5ZFUUN3ME2wMlAyOzB{IN88US=> NUH4c5ByW0GQR1XS
K5 MlfzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M132WWlEPTB;MD6wNVMxQCEQvF2= NF21eVFUSU6JRWK=
T84 NFPHfoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGK3eYhKSzVyPUCuNFE{OzFizszN NGDH[ZRUSU6JRWK=
TE-15 Mo\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTRVGM2UUN3ME2wMlAyOzN4IN88US=> NH7iNYpUSU6JRWK=
NCI-H460 NFvDU3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTBwMEGzN|Yh|ryP MYHTRW5ITVJ?
NTERA-S-cl-D1 MmL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH23XItKSzVyPUCuNFE{OzlizszN M{LMOHNCVkeHUh?=
KYSE-450 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTBwMEGzOFkh|ryP MmnQV2FPT0WU
H4 NWmyPFhQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFmxNYpKSzVyPUCuNFE{PjZizszN MVXTRW5ITVJ?
LC-2-ad MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PU[WlEPTB;MD6wNVM4KM7:TR?= M1fWb3NCVkeHUh?=
GAMG MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnFZ5dKSzVyPUCuNFE{PzFizszN Mlj6V2FPT0WU
TK10 M37HXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnNcno4UUN3ME2wMlAyOzh{IN88US=> MVfTRW5ITVJ?
NCI-H2122 NV7qSINrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVGyfHQ2UUN3ME2wMlAyOzh2IN88US=> MmnpV2FPT0WU
KM12 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmr1TWM2OD1yLkCxN|k6KM7:TR?= MmLWV2FPT0WU
CAL-39 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfDTWM2OD1yLkCxOFIh|ryP NUG5dnM2W0GQR1XS
RPMI-2650 NIm1OmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTrRnVKSzVyPUCuNFE1OzJizszN NYnPO3Q{W0GQR1XS
KYSE-510 M4\UbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX61R5FkUUN3ME2wMlAyPDR{IN88US=> NYTH[I9LW0GQR1XS
KALS-1 MoLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXL3R2xRUUN3ME2wMlAyPDZ4IN88US=> NWH0SZZEW0GQR1XS
NCI-H1648 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTBwMEG0PVkh|ryP NVTuU2ttW0GQR1XS
ES4 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLUd3JRUUN3ME2wMlAyPTB{IN88US=> MXzTRW5ITVJ?
C-33-A NEC5WJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU[wcW05UUN3ME2wMlAyPTB7IN88US=> M3XqbXNCVkeHUh?=
MIA-PaCa-2 NV\nPJRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1n4dmlEPTB;MD6wNVUxQSEQvF2= MVHTRW5ITVJ?
Becker M4D4dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwMEG1NVQh|ryP MYLTRW5ITVJ?
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NCI-H2087 NGrCV|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTtdllKSzVyPUCuNFMzQDlizszN NYLpSIxFW0GQR1XS
U-87-MG Mme0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M376eGlEPTB;MD6wN|I6KM7:TR?= NXjBT4J6W0GQR1XS
BC-1 NXS1b5RZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfzTWM2OD1yLkCzN|Y4KM7:TR?= MlXEV2FPT0WU
ES7 NXP2RpFIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVK4XJJTUUN3ME2wMlA{Ozd2IN88US=> NIPrOIRUSU6JRWK=
Daudi M2TGXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwMEOzO|Yh|ryP MnH0V2FPT0WU
RS4-11 NHnFN3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwMEOzPFMh|ryP NUHqRVVOW0GQR1XS
JiyoyeP-2003 Ml3QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFe0OoFKSzVyPUCuNFM{QDhizszN NGX1b5FUSU6JRWK=
BL-70 NXjoOJBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTBwMEOzPFkh|ryP MoPIV2FPT0WU
OS-RC-2 NIX2PVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnjXnFLUUN3ME2wMlA{Ozl4IN88US=> NVfuW5VjW0GQR1XS
SF268 NH;ESFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HSTWlEPTB;MD6wN|QxOSEQvF2= MVnTRW5ITVJ?
BV-173 Ml7GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGe4[ZpKSzVyPUCuNFM1OjZizszN M1nBeXNCVkeHUh?=
DMS-273 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwMEO0O|kh|ryP M3rPSHNCVkeHUh?=
22RV1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwMEO1NFch|ryP M4\xNXNCVkeHUh?=
ES8 Ml7YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTFTWM2OD1yLkCzOVM5KM7:TR?= NVLrW4hXW0GQR1XS
KYSE-150 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn[1TWM2OD1yLkCzOlA5KM7:TR?= MmPEV2FPT0WU
HCC1569 MoPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrTSnV2UUN3ME2wMlA{PjB6IN88US=> NXq4d4dFW0GQR1XS
NB5 Mn62S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmi5TWM2OD1yLkCzOlE{KM7:TR?= MWnTRW5ITVJ?
G-402 MlPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7X[FFKSzVyPUCuNFM3OTRizszN NWD1boZQW0GQR1XS
NCI-H1693 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTndo1KSzVyPUCuNFM3OTdizszN MmjwV2FPT0WU
LB2241-RCC Ml74S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTBwMEO2OFIh|ryP NGXGOYNUSU6JRWK=
KP-4 MoTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWGwfZh{UUN3ME2wMlA{PjZ|IN88US=> M2rrOXNCVkeHUh?=
ML-2 NVTNdJBST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwMEO2O|Eh|ryP MULTRW5ITVJ?
KU812 NHT6elJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzn[VFKSzVyPUCuNFM3QDRizszN MUTTRW5ITVJ?
LS-411N NIjC[ZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHlb25ZUUN3ME2wMlA{PzNzIN88US=> M3;E[3NCVkeHUh?=
OAW-42 NFL2XXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWH4bXYyUUN3ME2wMlA{PzR5IN88US=> M13IZnNCVkeHUh?=
HCC38 M4rsfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlX4TWM2OD1yLkCzO|cyKM7:TR?= M3;HUHNCVkeHUh?=
Ca-Ski NFnkWopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13HV2lEPTB;MD6wN|c5PCEQvF2= NYDwNmZyW0GQR1XS
Calu-3 NXzIcm9bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17CVGlEPTB;MD6wN|c5QSEQvF2= NXrOWVg2W0GQR1XS
KYSE-70 NIq0XJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3r3W2lEPTB;MD6wN|gyOiEQvF2= M3LiUnNCVkeHUh?=
D-392MG MlPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\JTWM2OD1yLkCzPFQzKM7:TR?= MXHTRW5ITVJ?
OVCAR-4 M1X0[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXjTWM2OD1yLkCzPFU5KM7:TR?= MWTTRW5ITVJ?
Detroit562 M2j0bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTBwMEO4O|Ih|ryP Mli0V2FPT0WU
HEL MnvWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{OyUWlEPTB;MD6wN|g6OSEQvF2= NFz6c2RUSU6JRWK=
MONO-MAC-6 MoX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmW3TWM2OD1yLkCzPFk{KM7:TR?= M3[0bXNCVkeHUh?=
LoVo M4\0NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFL3e4FKSzVyPUCuNFM6OzNizszN NWKyeId2W0GQR1XS
U-2-OS NX7rXJFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7TdnJzUUN3ME2wMlA{QTN3IN88US=> MXTTRW5ITVJ?
A172 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTBwMEO5OUDPxE1? M1;5cXNCVkeHUh?=
OCUB-M MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELPSmNKSzVyPUCuNFM6PjFizszN MlrFV2FPT0WU
SW48 M4S1OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofiTWM2OD1yLkC0NFMyKM7:TR?= MXjTRW5ITVJ?
HC-1 NHX1S3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjoTWM2OD1yLkC0NFY6KM7:TR?= NYnQ[WhRW0GQR1XS
KOSC-2 NFrJSplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHsO4JxUUN3ME2wMlA1OTFizszN NWe5VpNiW0GQR1XS
HDLM-2 NYDhZZJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXiW|MxUUN3ME2wMlA1OTF2IN88US=> M{XDR3NCVkeHUh?=
CTV-1 NULsPGlCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3y2VGlEPTB;MD6wOFEyPiEQvF2= MXnTRW5ITVJ?
SH-4 NV7oSHhzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXWNmVKSzVyPUCuNFQyPDFizszN MWLTRW5ITVJ?
SW756 MlPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPLe5lKSzVyPUCuNFQyPTdizszN MYrTRW5ITVJ?
GCT NIK4O|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XvV2lEPTB;MD6wOFE3OSEQvF2= MmPpV2FPT0WU
CHL-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTKTWM2OD1yLkC0NVY6KM7:TR?= NYTXVFB7W0GQR1XS
LAMA-84 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PVTWlEPTB;MD6wOFE4OSEQvF2= MkfVV2FPT0WU
LS-1034 NV;tZnFRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vyNGlEPTB;MD6wOFE6OSEQvF2= M1e3bXNCVkeHUh?=
NCI-H358 NXnaN4c2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{L5NmlEPTB;MD6wOFIyOiEQvF2= MYjTRW5ITVJ?
NB13 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfhNHFKSzVyPUCuNFQzOjdizszN Mo\2V2FPT0WU
TE-9 MkLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwMESyN|ch|ryP M1\nPXNCVkeHUh?=
OE33 NX\hXllnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvmTWM2OD1yLkC0NlQyKM7:TR?= MWjTRW5ITVJ?
CAL-120 Mm\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\YTWM2OD1yLkC0NlQyKM7:TR?= NGPxNFVUSU6JRWK=
DJM-1 MmHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjWTWM2OD1yLkC0NlczKM7:TR?= MmTBV2FPT0WU
SK-MEL-24 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXrR2pKSzVyPUCuNFQzQDNizszN MVPTRW5ITVJ?
VA-ES-BJ MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTBwMESyPVIh|ryP MkezV2FPT0WU
MMAC-SF NYLaWYNRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LYXmlEPTB;MD6wOFI6PyEQvF2= NH7jNFFUSU6JRWK=
MZ7-mel MmrVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfvU2hKSzVyPUCuNFQ{OyEQvF2= MXzTRW5ITVJ?
BxPC-3 NET6PGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXNTWM2OD1yLkC0N|QyKM7:TR?= M3PVbHNCVkeHUh?=
HT-29 M2HQbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfEbVVKSzVyPUCuNFQ{PTdizszN MmLnV2FPT0WU
SK-MEL-30 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfMVGxKSzVyPUCuNFQ{PjJizszN M3n4bXNCVkeHUh?=
CAL-33 M{HzWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHYRZNZUUN3ME2wMlA1Ozd3IN88US=> Ml7aV2FPT0WU
COLO-680N MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwMES0NFch|ryP NWrDO282W0GQR1XS
NH-12 M1\M[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDnTWM2OD1yLkC0OFQh|ryP M3fxUHNCVkeHUh?=
HCC1937 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3kTWM2OD1yLkC0OFU3KM7:TR?= MUXTRW5ITVJ?
IMR-5 NXzjbGxLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjlTWM2OD1yLkC0OFkh|ryP NH[zfnZUSU6JRWK=
MC-CAR MoXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwMES1Olkh|ryP MYXTRW5ITVJ?
NCI-H747 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrmdGtWUUN3ME2wMlA1PTdizszN MmjNV2FPT0WU
NCI-H1792 M3O0WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFKxdY9KSzVyPUCuNFQ2QDFizszN Mn36V2FPT0WU
SW13 NXzLe4FMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfkdYNKSzVyPUCuNFQ2QSEQvF2= M2m0NnNCVkeHUh?=
MLMA NIPqb|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwMES2NFkh|ryP MofwV2FPT0WU
U251 M2\PXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXu3NWNLUUN3ME2wMlA1PzZ|IN88US=> NFH2b4xUSU6JRWK=
U031 M4r4T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPQTWM2OD1yLkC0O|cyKM7:TR?= M3O0fnNCVkeHUh?=
ME-180 NIPlcYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwMES3PFIh|ryP NVzzcYlZW0GQR1XS
SK-MEL-3 MlntS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwMES4NFIh|ryP MlL6V2FPT0WU
MOLT-4 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XDU2lEPTB;MD6wOFgxOyEQvF2= M1HjVnNCVkeHUh?=
PF-382 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIO1T5lKSzVyPUCuNFQ5OjZizszN MX;TRW5ITVJ?
NUGC-3 NH3FUZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHiTYJKSzVyPUCuNFQ5OjdizszN MWHTRW5ITVJ?
NCI-H1417 Mn7WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2WybGlEPTB;MD6wOFg6KM7:TR?= MWTTRW5ITVJ?
COLO-205 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XN[WlEPTB;MD6wOFkyQSEQvF2= MXjTRW5ITVJ?
TE-441-T NUDrOXFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTBwMES5N{DPxE1? NGK4SW5USU6JRWK=
MKN1 NGr0RXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3uTWM2OD1yLkC0PVMh|ryP M2PEc3NCVkeHUh?=
UM-UC-3 NYTuO25lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfITWM2OD1yLkC0PVUh|ryP M3fBdXNCVkeHUh?=
SF126 M{ntdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTBwMEWwNUDPxE1? M3y0OXNCVkeHUh?=
LB1047-RCC NVzRR2JJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnH6TWM2OD1yLkC1NFMyKM7:TR?= NV25cpdCW0GQR1XS
A253 M4PqcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\tNHJKSzVyPUCuNFUxPTJizszN M1r4OnNCVkeHUh?=
NCI-H1963 M{KyWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnsTWM2OD1yLkC1NVc3KM7:TR?= M1fBcnNCVkeHUh?=
VM-CUB-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTlZpRSUUN3ME2wMlA2OzFzIN88US=> M2TRZXNCVkeHUh?=
T-24 MmPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXORZRkUUN3ME2wMlA2Ozh2IN88US=> MUDTRW5ITVJ?
K-562 NF:2c4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH23cphKSzVyPUCuNFU{QDdizszN MkTIV2FPT0WU
ARH-77 M1XTPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPITWM2OD1yLkC1N|k2KM7:TR?= NVzTV5FzW0GQR1XS
CA46 MkXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HxbmlEPTB;MD6wOVQ{KM7:TR?= MYrTRW5ITVJ?
HCC70 M1u1XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTBwMEW0OVIh|ryP M4\zTXNCVkeHUh?=
ST486 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnLcoQ2UUN3ME2wMlA2PTJ3IN88US=> MXXTRW5ITVJ?
COLO-741 NIPmXYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPz[Y9YUUN3ME2wMlA2PTNzIN88US=> NFW1RpVUSU6JRWK=
SK-PN-DW Mn3uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1X3TmlEPTB;MD6wOVU5QCEQvF2= MnrrV2FPT0WU
BL-41 M4qwRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2G5UWlEPTB;MD6wOVU6PiEQvF2= NF\4S5ZUSU6JRWK=
D-263MG NWrSTop1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rCXGlEPTB;MD6wOVY5OyEQvF2= NFq5XIFUSU6JRWK=
KE-37 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwMEW2PFMh|ryP MWfTRW5ITVJ?
LU-134-A MkPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPGZ5NKSzVyPUCuNFU4OTVizszN M4jGNXNCVkeHUh?=
HCC2157 NIrhfWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorjTWM2OD1yLkC1O|M{KM7:TR?= MnL2V2FPT0WU
GAK MkK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zBeWlEPTB;MD6wOVc{PCEQvF2= Ml;tV2FPT0WU
IST-SL2 MkD2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHO1TFBKSzVyPUCuNFU4PDNizszN MVjTRW5ITVJ?
KMOE-2 MmLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DIZmlEPTB;MD6wOVc1QSEQvF2= M{jCPXNCVkeHUh?=
SW1573 M4XCcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTRTWM2OD1yLkC1PFAzKM7:TR?= M3rFV3NCVkeHUh?=
SCC-9 NH7xOHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwMEW4O{DPxE1? M{ju[nNCVkeHUh?=
MDA-MB-361 MkLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPp[np[UUN3ME2wMlA2QDd{IN88US=> MVvTRW5ITVJ?
BHT-101 MmXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;MbFdKSzVyPUCuNFU5PzZizszN NYiwbYFuW0GQR1XS
NCI-H1770 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlm3TWM2OD1yLkC1PFc6KM7:TR?= MljuV2FPT0WU
UACC-893 Moq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\lcoJ{UUN3ME2wMlA2QDl4IN88US=> MniyV2FPT0WU
NCI-H226 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHq4WYFKSzVyPUCuNFU6QDhizszN MY\TRW5ITVJ?
HLE NVL4SYZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwME[wPFIh|ryP MoHBV2FPT0WU
NCI-H1703 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HKb2lEPTB;MD6wOlE4QCEQvF2= MkDJV2FPT0WU
KURAMOCHI MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILoO5hKSzVyPUCuNFYyQDlizszN MVvTRW5ITVJ?
RH-1 Mm[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwME[yN{DPxE1? M1zGZ3NCVkeHUh?=
DSH1 MofHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIradWxKSzVyPUCuNFYzPyEQvF2= NVvvO2VwW0GQR1XS
CAMA-1 M4LneWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWThO5NiUUN3ME2wMlA3OzB|IN88US=> NF3JT2ZUSU6JRWK=
NCI-H1437 NFiyOFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3YPHY4UUN3ME2wMlA3OzJ6IN88US=> NXLjdFF4W0GQR1XS
HuP-T4 M1m1VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkK4TWM2OD1yLkC2OVg3KM7:TR?= MnraV2FPT0WU
HCT-15 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPXXIVKSzVyPUCuNFY2QTdizszN M{\mRXNCVkeHUh?=
NCCIT Ml;US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTn[ow5UUN3ME2wMlA3PjB2IN88US=> M1PNZXNCVkeHUh?=
BOKU Mom1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTBwME[2O|Qh|ryP NXfuTmVYW0GQR1XS
FADU NYDVZWN7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nM[2lEPTB;MD6wOlc1PSEQvF2= MmrEV2FPT0WU
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NCI-H64 NILyTmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTFwMUW0NkDPxE1? M4LUcXNCVkeHUh?=
SW1463 NFPHPYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfCSZNKSzVyPUGuNVg{PDlizszN NF;4T2lUSU6JRWK=
SK-MEL-1 NF\LeIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTFwMkC1PVUh|ryP M1PV[XNCVkeHUh?=
TALL-1 M3zqfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fXWmlEPTB;MT6yOVE3PSEQvF2= NF\oNmRUSU6JRWK=
RO82-W-1 MoH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzBZ|RKSzVyPUGuN|M{OzlizszN NVjsO41OW0GQR1XS
NCI-H1581 NFuzRlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTzZodRUUN3ME2xMlM2Pjh5IN88US=> NWT6VnJpW0GQR1XS
NCI-H748 M3fJdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvzcHJKSzVyPUGuN|U4OzhizszN NFLqNVdUSU6JRWK=
HCC1187 MmHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTFwNUW1NlIh|ryP NUXZN|RGW0GQR1XS
EoL-1-cell MkSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjSRnVQUUN3ME2xMlU5QDh7IN88US=> MWHTRW5ITVJ?
HuO-3N1 NWTSfJA3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGroZoVKSzVyPUGuPFM1OTJizszN M1uyVnNCVkeHUh?=
NCI-H1793 MnnGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjZTWM2OD1zLki3OVk{KM7:TR?= MVjTRW5ITVJ?
Caov-3 M1HL[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTJwMEC2NlUh|ryP NY\HSIJrW0GQR1XS
JAR NYLDe5NsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTJwMEe5NkDPxE1? MkHQV2FPT0WU
SK-MEL-28 M2HtNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HIcmlEPTB;Mj6xPFA6QCEQvF2= NUfaZZhTW0GQR1XS
EM-2 NVjTTYRNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnHT3FKSzVyPUKuNlAzQTNizszN NVriRo9kW0GQR1XS
Mewo NGLDNFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTJwMkKyOlUh|ryP NEDRfIJUSU6JRWK=
NCI-H720 NHKyV4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4O5Z2lEPTB;Mj6yOlU5PSEQvF2= NGfubJhUSU6JRWK=
CAL-54 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTJwMk[3PVUh|ryP M2q2e3NCVkeHUh?=
MC116 NIfRb5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\6[WlEPTB;Mj6zOlM6PyEQvF2= MlL3V2FPT0WU
DG-75 NFzJZYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTJwNEi1O|Yh|ryP MXvTRW5ITVJ?
HCC1143 NWHGRo5{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\TTHlKSzVyPUKuOVA3PThizszN MWPTRW5ITVJ?
FTC-133 NWfiS4ZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjSTWM2OD1{LkWzOlg6KM7:TR?= MYPTRW5ITVJ?
AsPC-1 NUeyN213T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTQWoJZUUN3ME2yMlU{QTJ7IN88US=> MmPYV2FPT0WU
NCI-H889 NU\lbJh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDqTWtKSzVyPUKuOVY4ODZizszN MVTTRW5ITVJ?
HT55 MnXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXiyWJpuUUN3ME2yMlYzODF7IN88US=> MWfTRW5ITVJ?
UMC-11 NIHpXlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{naXGlEPTB;Mj63PFcyPSEQvF2= MmTCV2FPT0WU
P12-ICHIKAWA M2XtSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGC3OZZKSzVyPUKuPFIxPDZizszN M1vrN3NCVkeHUh?=
HCC1395 MonFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTaTWM2OD1{Lkm4OlAzKM7:TR?= NWPtUm1SW0GQR1XS
D-283MED NEP1epFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXWfIdKSzVyPUOuNVg6OzdizszN NV;tSJh6W0GQR1XS
COLO-800 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\jTWM2OD1|LkOzPFk4KM7:TR?= NFjOcpJUSU6JRWK=
MFM-223 M4jsSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTaXGVbUUN3ME2zMlM3ODl5IN88US=> M3TNR3NCVkeHUh?=
TE-5 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HuemlEPTB;ND61OlE1PyEQvF2= M1zGTHNCVkeHUh?=
NCI-H209 NWfPVWl5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTRwN{i1O|Ih|ryP Mnq4V2FPT0WU
SiHa MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHRfYxsUUN3ME20Mlk2OjB|IN88US=> M4jwPXNCVkeHUh?=
NCI-H1395 MkLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnOUlhKSzVyPUWuNVA3OzNizszN NVnIXHV7W0GQR1XS
A498 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoX2TWM2OD13LkKxNlUyKM7:TR?= M2DW[3NCVkeHUh?=
ES5 NUG3S|g2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfUUXNKSzVyPUWuOlEyPzhizszN M3WyPHNCVkeHUh?=
MDA-MB-157 MnjMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXX2[G05UUN3ME21MlY3PDR|IN88US=> MlvPV2FPT0WU
NCI-H1623 NYLPfpFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3sTWM2OD13LkizOVU3KM7:TR?= M1jmfHNCVkeHUh?=
RPMI-8866 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjSO3dKSzVyPUWuPFQ4QTJizszN MnG2V2FPT0WU
LC-1F M3viWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzJT4FKSzVyPU[uNFkzQTFizszN NV;hU21EW0GQR1XS
TCCSUP M{PqdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfWcG56UUN3ME22MlYxOzR7IN88US=> Ml64V2FPT0WU
TT M3jUVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoWxTWM2OD16LkOzNFA6KM7:TR?= NVi0V5dNW0GQR1XS
NCI-H1838 MmLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfqV2xKSzVyPUiuOVE4OzFizszN NWryRmJTW0GQR1XS
NCI-H322M MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{Dme2lEPTB;OT6xOlI5OSEQvF2= MnnyV2FPT0WU
NCI-H187 NELQSZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHHNGdZUUN3ME25MlUyQDN3IN88US=> NXK4THN[W0GQR1XS
SBC-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;ITWM2OD17LkmzOlU3KM7:TR?= NUHtVmJzW0GQR1XS
SCC-3 NVLucIxrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrwWFhbUUN3ME2xNE42Pjd7IN88US=> MljVV2FPT0WU
SW948 M{PiWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX70bVgyUUN3ME2xNE44PTFzIN88US=> NYPoflNIW0GQR1XS
CPC-N MoPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTFzLkCwO{DPxE1? MVTTRW5ITVJ?
TGBC24TKB NXfDSolbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPQfnFKSzVyPUGzMlUzQSEQvF2= M3;SVnNCVkeHUh?=
NCI-H2452 NYfYcWtGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MneyTWM2OD1zND63N{DPxE1? MYHTRW5ITVJ?
Hs-578-T M{fyR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrVN2RKSzVyPUG4MlU4PTlizszN NGnheWdUSU6JRWK=
DV-90 M3PJVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTF6Lkm5OFUh|ryP NXX1fYZvW0GQR1XS
NCI-H1563 NEf4[YtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTF7Lke4PFgh|ryP NF23b3VUSU6JRWK=
SW780 NHSyPXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXMTWM2OD1{MT6xN|E5KM7:TR?= NX[0U|llW0GQR1XS
NCI-H345 MnHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTJzLki3O|kh|ryP NGPwfnhUSU6JRWK=
LB771-HNC NEHKO45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nnZ2lEPTB;MkKuOFgyOyEQvF2= NIjIXWtUSU6JRWK=
RT4 NWLuWpVsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTJ|LkOyPFIh|ryP NIPJWYdUSU6JRWK=
NCI-H82 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PXTGlEPTB;MkOuOVUzPiEQvF2= NF3OdVdUSU6JRWK=
NCI-H524 M4q4Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;zfmlEPTB;MkSuN|gyOiEQvF2= NXfzTHZbW0GQR1XS
SNU-C1 Ml\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3COWZKSzVyPUK0MlkyODVizszN Mn;QV2FPT0WU
NCI-SNU-16 NWP0UmlwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTR6LkOxOFIh|ryP MmizV2FPT0WU

... Click to View More Cell Line Experimental Data

体内研究 使用NVP-AUY922可引起强的抗癌反应,可抑制HSC-2移植瘤模型中p-Akt和VEGF的表达。[2] 在12种实验肿瘤中观察到5种肿瘤衰退。体重降低<5%,且与HSP90相关的生物标签明显改变。BT474中, ERBB2完全缺失,ERα耗尽,且CDK4和磷酸化ERK1/2降低。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[3]
+ 展开

激酶实验:

NVP-AUY922溶解在DMSO中,浓度为10mM。通过作用于HSP90α, HSP90β, GRP94, TRAP-1, HSP72,和拓扑异构酶II评估NVP-AUY922的活性。
细胞实验:[1]
+ 展开
  • Cell lines: 人类胃癌细胞系NCI-N87
  • Concentrations: 1 μM
  • Incubation Time: 3天
  • Method: 人类胃癌细胞NCI-N87按5-7×103密度接种在96孔板中,每孔接种50ul,在37oC下温育24小时,然后用NVP-AUY922处理1到3天。实验处理后,使用MTT实验测细胞活力,用酶标仪分析。
    (Only for Reference)
动物实验:[3]
+ 展开
  • Animal Models: 携带WM266.4人类黑色素移植瘤的雌性NCr无胸腺鼠
  • Formulation: 溶于在DMSO中,用无菌盐水/Tween-20稀释。
  • Dosages: 50 mg/kg
  • Administration: 静脉注射或腹腔注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 93 mg/mL warmed (199.76 mM)
Ethanol 31 mg/mL (66.58 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
1% DMSO+30% polyethylene glycol+1% Tween 80
30 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 465.54
化学式

C26H31N3O5

CAS号 747412-49-3
稳定性 powder
in solvent
别名 VER-52296

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01784640 Active not recruiting Recurrent Non-small Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI) January 31 2014 Phase 1
NCT01922583 Completed Non-small Cell Lung Cancer (NSCLC) National Taiwan University Hospital January 2014 Phase 2
NCT01854034 Completed Non Small Cell Lung Cancer Massachusetts General Hospital July 2013 Phase 2
NCT01772797 Completed Anaplastic Lymphoma Kinase (ALK)|Non-small Cell Lung Cancer Novartis Pharmaceuticals|Novartis June 2013 Phase 1
NCT01752400 Completed Non Small Cell Lung Cancer Massachusetts General Hospital January 2013 Phase 2
NCT01613950 Completed Stomach Neoplasms Esophageal Neoplasms Metastatic Gastric Cancer Mutated PI3KCA Protein Overexpressed HER2 Protein Novartis Pharmaceuticals|Novartis December 2012 Phase 1

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

HSP (e.g. HSP90) Signaling Pathway Map

HSP (e.g. HSP90) Inhibitors with Unique Features

相关HSP (e.g. HSP90)产品

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID