Luminespib (NVP-AUY922)

For research use only. Not for use in humans.

目录号：S1069 别名： AUY-922, VER-52296

Luminespib (NVP-AUY922) Chemical Structure

CAS No. 747412-49-3

Luminespib (AUY-922, NVP-AUY922, VER-52296)是一种高效的HSP90抑制剂，无细胞试验中作用于HSP90α/β的IC50为13 nM /21 nM，对HSP90家族成员GRP94和TRAP-1具有稍弱的作用，与任何小分子HSP90配体均可紧密结合。Luminespib (AUY-922, NVP-AUY922)可有效下调并使IGF-1Rβ蛋白不稳定，从而导致抑制生长、自噬和凋亡。Phase 2。

规格

价格

库存

购买数量

10mM (1mL in DMSO)	RMB 2620.46	现货
5mg	RMB 1303.22	现货
10mg	RMB 2216.44	现货
25mg	RMB 3853.15	现货
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客户使用Selleck生产的Luminespib (NVP-AUY922)发表文献97篇：

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Biomedicines, 2022, 10(3)624

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Cell Death Discov, 2022, 8(1):86

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Cell Rep, 2021, 34(11):108870

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Haematologica, 2021, 10.3324/haematol.2021.278743

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Cancers (Basel), 2021, 13(15)3850

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Cells, 2021, 10(6)1489

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Cell Chem Biol, 2021, S2451-9456(21)00221-X

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Cancer Sci, 2021, 10.1111/cas.15204

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Int J Mol Sci, 2021, 22(5)2538

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Sci Rep, 2021, 11(1):11103

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Cell Stress Chaperones, 2021, 10.1007/s12192-021-01193-6

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Hemasphere, 2021, 5(7):e593

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Neurobiol Dis, 2021, S0969-9961(21)00048-6

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Nat Commun, 2020, 11(1):562

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Genome Med, 2020, 18;12(1):17

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Cell Rep, 2020, 31(12):107800

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Front Immunol, 2020,

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Int J Mol Sci, 2020, 21(13):E4740

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Int J Mol Med, 2020, 45(5):1543-1553

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Exp Lung Res, 2020, 46(6):203-216

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Korean J Physiol Pharmacol, 2020, 1;24(3):241-248

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Nat Commun, 2019, 10(1):402

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J Neurosci, 2019, 39(17):3332-3344

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Cells, 2019, 8(8)

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Mol Cancer Ther, 2019, 18(11):2097-2110

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Front Endocrinol (Lausanne), 2019, 10:487

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BMC Cancer, 2019, 19(1):102

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Clin Exp Med, 2019, 10.1007/s10238-019-00587-2

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Hepatology, 2019, 69(2):573-586

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ACS Chem Neurosci, 2019, 10(6):2890-2902

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Transl Lung Cancer Res, 2019, 8(4):340-351

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Autophagy, 2018, 14(6):958-971

PubMed: 29561705 ( click the link to review the publication )

Clin Cancer Res, 2018, 24(24):6548-6555

PubMed: 30154228 ( click the link to review the publication )

Mol Syst Biol, 2018, 14(3):e7858

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J Immunol, 2018,

PubMed: 29445007 ( click the link to review the publication )

J Virol, 2018, 92(5)e01415-17

PubMed: 29212943 ( click the link to review the publication )

J Cell Mol Med, 2018, 22(3):1792-1804

PubMed: 29363851 ( click the link to review the publication )

J Biol Chem, 2018, 293(7):2370-2380

PubMed: 29255093 ( click the link to review the publication )

BMB Rep, 2018, 51(12):660-665

PubMed: 30591093 ( click the link to review the publication )

Oncotarget, 2018, 9(100):37379-37392

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Oncotarget, 2018,

PubMed: 29599910 ( click the link to review the publication )

Oncotarget, 2018, 9(13):11303-11321

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Cancer Lett, 2017, 411:19-26

PubMed: 28987383 ( click the link to review the publication )

Cancer Chemother Pharmacol, 2017, 80(4):673-684

PubMed: 28779264 ( click the link to review the publication )
Biochem Biophys Res Commun, 2017, 487(2):313-319

PubMed: 28412368 ( click the link to review the publication )

Onco Targets Ther, 2017, 10:2219-2226

PubMed: 28458565 ( click the link to review the publication )

Sci Rep, 2017, 7(1):201

PubMed: 28298630 ( click the link to review the publication )

Oncotarget, 2017, 8(61):104193-104205

PubMed: 29262632 ( click the link to review the publication )

Oncotarget, 2017, 8(28):45298-45310

PubMed: 28424411 ( click the link to review the publication )

Oncotarget, 2017, 8(35):58771-58780

PubMed: 28938595 ( click the link to review the publication )

Oncogene, 2016, 35(3):333-43

PubMed: 25823022 ( click the link to review the publication )

Cancer Lett, 2016, 372(1):75-81

PubMed: 26723875 ( click the link to review the publication )

PLoS Genet, 2016, 12(9):e1006279

PubMed: 27588951 ( click the link to review the publication )

Sci Rep, 2016, 6:33710

PubMed: 27641368 ( click the link to review the publication )

J Biol Chem, 2016, 291(19):10332-46

PubMed: 26957545 ( click the link to review the publication )

Horm Cancer, 2016, 7(2):114-26

PubMed: 26858237 ( click the link to review the publication )

PeerJ, 2016, 4:e1683

PubMed: 26893968 ( click the link to review the publication )

Medicinal Chemistry Research, 2016, 10.1007/s00044-016-1553-7

PubMed: ( click the link to review the publication )

Oncotarget, 2016, 7(31):49597-49610

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Oncotarget, 2016, 7(25):38191-38209

PubMed: 27224913 ( click the link to review the publication )

Immun Inflamm Dis, 2016, 4(4):463-473

PubMed: 27980780 ( click the link to review the publication )

PLoS Negl Trop Dis, 2015, 8(2):e2699

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Biochimica et Biophysica Acta, 2015, 10.1016/j.bbamcr.2015.05.012

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Am J Physiol Lung Cell Mol Physiol, 2015, 309(12):L1410-9

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Int J Biol Sci, 2015, 11(8):923-34

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Molecules, 2015, 20(1):1643-60

PubMed: 25608045 ( click the link to review the publication )

Biochemistry, 2015, 10.1021/acs.biochem.5b00148

PubMed: 25905789 ( click the link to review the publication )

PLoS One, 2015, 10(3):e0119832

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Mol Med Rep, 2015, 12(2):2451-6

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Oncol Lett, 2015, 10(2):941-945

PubMed: 26622600 ( click the link to review the publication )

Oncotarget, 2015,

PubMed: 26416354 ( click the link to review the publication )

Oncotarget, 2015, 6(31):31792-804

PubMed: 26397139 ( click the link to review the publication )

Oncoscience, 2015, 2(4):419-427

PubMed: 26097875 ( click the link to review the publication )

Nat Commun, 2014, 5:3361

PubMed: 24553445 ( click the link to review the publication )

Proc Natl Acad Sci USA, 2014, 111(15):E1528-37

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Int J Cancer, 2014, 135(10):2462-74

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Mol Cancer Res, 2014, 12(7):1042-54

PubMed: 24784839 ( click the link to review the publication )

PLoS Negl Trop Dis, 2014, 8(2):e2699

PubMed: 24551261 ( click the link to review the publication )

Am J Respir Cell Mol Biol, 2014, 50(1):170-9

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Cell Signal, 2014, 27(2):293-305

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PLoS One, 2014, 9(10):e111146

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PLoS One, 2014, 9(12):e114506

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Tumour Biol, 2014, 35(8):8193-9

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Mol Oncol, 2013, 7(6):1093-102

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J Biol Chem, 2013, 288(23):16308-20

PubMed: 23599433 ( click the link to review the publication )

J Proteome Res, 2013, 12(8):3697-706

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Toxicol Appl Pharmacol, 2013, 273(2):401-9

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PLoS One, 2013, 8(9):e74257

PubMed: 24066127 ( click the link to review the publication )

PLoS Pathog, 2012, 8(11):e1003048

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Br J Haematol, 2012, 160(4):465-76

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Mol Cell Biochem, 2012, 370(1-2):141-50

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American Society of Clinical Oncology Annual Meeting, 2012, Chicago

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Mol Cancer, 2011, 10:125

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产品安全说明书

HSP (HSP90)抑制剂选择性比较

生物活性

产品描述

靶点

HSP90α ^[1] (Cell-free assay)	HSP90β ^[1] (Cell-free assay)
13 nM	21 nM

体外研究

体外研究时NVP-AUY922抑制多种人类肿瘤细胞系的增殖，GI50平均值为9 nM。NVP-AUY922作用于胃癌细胞时IC50值为2到40 nM。NVP-AUY922作用于BEAS-2B细胞IC50为28.49 nM。使用NVP-AUY922时不影响HSP90的表达，但是提高HSP70的表达。NVP-AUY922增强HSP70与HSP90的结合能力。NVP-AUY922造成p23与HSP复合体的分离。NVP-AUY922能使HSP70结合到HSP90复合体。使用NVP-AUY922，引起酪氨酸激酶受体如VEGFR1, 2, 3和PDGFR-ɑ的表达下降，Akt和p-Akt也下降。另外，NVP-AUY922作用于NCI-N87细胞，引起HER2表达下降。NVP-AUY922提高HSP90与目标蛋白的结合力，然后通过蛋白酶使蛋白降解。NVP-AUY922可以改变多条信号通路而影响细胞生长。此外，使用蛋白酶抑制剂MG132，恢复由于使用NVP-AUY922而降低的胸核苷酸合酶的重新表达。^[1]NVP-AUY922提高cleaved caspase-3的表达，及导致HSC-2 细胞凋亡。^[2]

Cell Data

Cell Lines	Assay Type	Activity Description	PMID
NCI-SNU-16	M1W3S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3LIUGlEPTB;NEiuN\|E1OiEQvF2=	NYTnfJhoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV{MU[0M{c,W0GQR1XSQE9iRg>?
SNU-C1	M{HzPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MofTTWM2OD1{ND65NVA2KM7:TR?=	M2jte\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2OjF4ND:nQnNCVkeHUkyvZV4>
NCI-H524	NH\CbGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2DMemlEPTB;MkSuN\|gyOiEQvF2=	MlmzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlUzOTZ2Lze+V2FPT0WUPD;hQi=>
NCI-H82	MmLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIDBSmRKSzVyPUKzMlU2OjZizszN	NIfhRZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTJzNkSvK\|5USU6JRWK8M4E,
RT4	NX3PfHRwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHS2XHRKSzVyPUKzMlMzQDJizszN	NEjkeHk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTJzNkSvK\|5USU6JRWK8M4E,
LB771-HNC	NXrUfVNNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVrJR\|UxRTJ{LkS4NVMh\|ryP	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVIyPjRxJ{7TRW5ITVJ:L3G+
SW780	MkW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVjJR\|UxRTJzLkGzNVgh\|ryP	Ml[xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlUzOTZ2Lze+V2FPT0WUPD;hQi=>
NCI-H345	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXjyTHZzUUN3ME2yNU45Pzd7IN88US=>	NF:3Tno9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTJzNkSvK\|5USU6JRWK8M4E,
NCI-H1563	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGDaTG9KSzVyPUG5Mlc5QDhizszN	MlOyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlUzOTZ2Lze+V2FPT0WUPD;hQi=>
DV-90	Mlj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmPzTWM2OD1zOD65PVQ2KM7:TR?=	M3zQdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2OjF4ND:nQnNCVkeHUkyvZV4>
Hs-578-T	NVe2Xo1NT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3XLXmlEPTB;MUiuOVc2QSEQvF2=	NYro[Ix3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV{MU[0M{c,W0GQR1XSQE9iRg>?
NCI-H2452	NHXRe2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M37id2lEPTB;MUSuO\|Mh\|ryP	M1i5[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2OjF4ND:nQnNCVkeHUkyvZV4>
TGBC24TKB	NYXad3VFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NV;BcHR[UUN3ME2xN{42OjlizszN	NIeyd\|I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTJzNkSvK\|5USU6JRWK8M4E,
SW948	NV7RS5M3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYHJR\|UxRTFyLke1NVEh\|ryP	NEfWbXk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTJzNkSvK\|5USU6JRWK8M4E,
CPC-N	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIPh[2lKSzVyPUGxMlAxPyEQvF2=	Ml3hQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlUzOTZ2Lze+V2FPT0WUPD;hQi=>
SCC-3	M2jyN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkK0TWM2OD1zMD61Olc6KM7:TR?=	M1jiXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2OjF4ND:nQnNCVkeHUkyvZV4>
SBC-1	MnvJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NX;Xc\|k1UUN3ME25Mlk{PjV4IN88US=>	MnztQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlUzOTZ2Lze+V2FPT0WUPD;hQi=>
NCI-H187	M{O1cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVHJR\|UxRTlwNUG4N\|Uh\|ryP	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVIyPjRxJ{7TRW5ITVJ:L3G+
NCI-H1838	MnjWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mn35TWM2OD16LkWxO\|MyKM7:TR?=	M3u3OlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2OjF4ND:nQnNCVkeHUkyvZV4>
NCI-H322M	NVLSUIQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYDIWG9OUUN3ME25MlE3OjhzIN88US=>	NGr6U209[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTJzNkSvK\|5USU6JRWK8M4E,
TT	NInWNGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYm5PYpRUUN3ME24MlM{ODB7IN88US=>	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVIyPjRxJ{7TRW5ITVJ:L3G+
TCCSUP	NEHXeYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYn5dI5CUUN3ME22MlYxOzR7IN88US=>	MnnEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlUzOTZ2Lze+V2FPT0WUPD;hQi=>
LC-1F	M1vo[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M13HWGlEPTB;Nj6wPVI6OSEQvF2=	NUHrOVFKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV{MU[0M{c,W0GQR1XSQE9iRg>?
RPMI-8866	M1[1fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NH7VZmJKSzVyPUWuPFQ4QTJizszN	M1zqSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2OjF4ND:nQnNCVkeHUkyvZV4>
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NCI-H1395	NGnhOpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVfJR\|UxRTVwMUC2N\|Mh\|ryP	Mn3KQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlUzOTZ2Lze+V2FPT0WUPD;hQi=>
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NCI-H209	NGHr[WdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{HuOGlEPTB;ND63PFU4OiEQvF2=	NXjCPIlMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV{MU[0M{c,W0GQR1XSQE9iRg>?
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MFM-223	NWjFRnZqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWLrepJDUUN3ME2zMlM3ODl5IN88US=>	MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVIyPjRxJ{7TRW5ITVJ:L3G+
COLO-800	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXHTbVVDUUN3ME2zMlM{QDl5IN88US=>	NVr3TYJsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV{MU[0M{c,W0GQR1XSQE9iRg>?
D-283MED	NH65eYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M13GXGlEPTB;Mz6xPFk{PyEQvF2=	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVIyPjRxJ{7TRW5ITVJ:L3G+
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HT55	M2rCbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NY\iRpkyUUN3ME2yMlYzODF7IN88US=>	M2jz[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2OjF4ND:nQnNCVkeHUkyvZV4>
UMC-11	NIjtfZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MULJR\|UxRTJwN{i3NVUh\|ryP	NHG3SVA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTJzNkSvK\|5USU6JRWK8M4E,
AsPC-1	M13KcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYTJR\|UxRTJwNUO5Nlkh\|ryP	M3G5WlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2OjF4ND:nQnNCVkeHUkyvZV4>
NCI-H889	NEPTSJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Ml2wTWM2OD1{LkW2O\|A3KM7:TR?=	MkHKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlUzOTZ2Lze+V2FPT0WUPD;hQi=>
HCC1143	M3nGdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEXD[nRKSzVyPUKuOVA3PThizszN	M2j3[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2OjF4ND:nQnNCVkeHUkyvZV4>
FTC-133	M1:1XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEDnXI1KSzVyPUKuOVM3QDlizszN	M1;GTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2OjF4ND:nQnNCVkeHUkyvZV4>
DG-75	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkDITWM2OD1{LkS4OVc3KM7:TR?=	MlzPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlUzOTZ2Lze+V2FPT0WUPD;hQi=>
MC116	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mme5TWM2OD1{LkO2N\|k4KM7:TR?=	NE\5RZU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTJzNkSvK\|5USU6JRWK8M4E,
CAL-54	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXe2bolDUUN3ME2yMlI3Pzl3IN88US=>	MlH4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlUzOTZ2Lze+V2FPT0WUPD;hQi=>
NCI-H720	M1vIOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3LaSGlEPTB;Mj6yOlU5PSEQvF2=	NH[0enI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTJzNkSvK\|5USU6JRWK8M4E,
EM-2	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGPUV21KSzVyPUKuNlAzQTNizszN	Mn[xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlUzOTZ2Lze+V2FPT0WUPD;hQi=>
Mewo	MofKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXXJR\|UxRTJwMkKyOlUh\|ryP	NFyyWmY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTJzNkSvK\|5USU6JRWK8M4E,
SK-MEL-28	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmO0TWM2OD1{LkG4NFk5KM7:TR?=	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVIyPjRxJ{7TRW5ITVJ:L3G+
JAR	MlXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Ml\mTWM2OD1{LkC3PVIh\|ryP	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVIyPjRxJ{7TRW5ITVJ:L3G+
Caov-3	NYTrPJQ4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M33UXWlEPTB;Mj6wNFYzPSEQvF2=	NIfYVog9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTJzNkSvK\|5USU6JRWK8M4E,
HuO-3N1	M3nRb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnTETWM2OD1zLkizOFEzKM7:TR?=	NXzhRWJ7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV{MU[0M{c,W0GQR1XSQE9iRg>?
NCI-H1793	NHXh[FhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MorkTWM2OD1zLki3OVk{KM7:TR?=	MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVIyPjRxJ{7TRW5ITVJ:L3G+
HCC1187	NUDxNmJjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHjpWoxKSzVyPUGuOVU2OjJizszN	NGfH[XQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTJzNkSvK\|5USU6JRWK8M4E,
EoL-1-cell	MkDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYe4VHJSUUN3ME2xMlU5QDh7IN88US=>	NUK1c\|d[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV{MU[0M{c,W0GQR1XSQE9iRg>?
NCI-H748	MmrCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVXJR\|UxRTFwM{W3N\|gh\|ryP	M2XlPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2OjF4ND:nQnNCVkeHUkyvZV4>
NCI-H1581	M1jMUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFvQWpFKSzVyPUGuN\|U3QDdizszN	NIn6PGo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTJzNkSvK\|5USU6JRWK8M4E,
RO82-W-1	MorsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYXCXY15UUN3ME2xMlM{OzN7IN88US=>	NInoXG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTJzNkSvK\|5USU6JRWK8M4E,
TALL-1	NYD6dWpVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIf4Z5pKSzVyPUGuNlUyPjVizszN	MkXtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlUzOTZ2Lze+V2FPT0WUPD;hQi=>
SK-MEL-1	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXTJR\|UxRTFwMkC1PVUh\|ryP	Ml3qQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlUzOTZ2Lze+V2FPT0WUPD;hQi=>
SW1463	NGnqeYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVuwSIVkUUN3ME2xMlE5OzR7IN88US=>	NXzrVpc3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV{MU[0M{c,W0GQR1XSQE9iRg>?
NCI-H64	NYrSfI1RT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVHJR\|UxRTFwMUW0NkDPxE1?	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVIyPjRxJ{7TRW5ITVJ:L3G+
P31-FUJ	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{PXUWlEPTB;MT6xNFc3PiEQvF2=	Ml7rQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlUzOTZ2Lze+V2FPT0WUPD;hQi=>
LP-1	NUj1VXRzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2rPTmlEPTB;MT6wOlk{KM7:TR?=	NV\IPWUyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV{MU[0M{c,W0GQR1XSQE9iRg>?
NCI-H2227	NFzXR3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{njO2lEPTB;MT6wOFk5OSEQvF2=	Mlf5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlUzOTZ2Lze+V2FPT0WUPD;hQi=>
HAL-01	MnTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXj5cYFzUUN3ME2wMlk6Ozd7IN88US=>	NILhWZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTJzNkSvK\|5USU6JRWK8M4E,
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Daudi	MmPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoHtTWM2OD1yLkCzN\|c3KM7:TR?=	NF\EOIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTJzNkSvK\|5USU6JRWK8M4E,
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HCC38	NFzifmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVLJR\|UxRTBwMEO3O\|Eh\|ryP	M13DOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2OjF4ND:nQnNCVkeHUkyvZV4>
Calu-3	NXPlflNyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NI\UcZNKSzVyPUCuNFM4QDlizszN	M3fvSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2OjF4ND:nQnNCVkeHUkyvZV4>
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KYSE-70	NH73UlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmHrTWM2OD1yLkCzPFEzKM7:TR?=	MkWzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlUzOTZ2Lze+V2FPT0WUPD;hQi=>
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HEL	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWTrdWU4UUN3ME2wMlA{QDlzIN88US=>	M4W3cFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2OjF4ND:nQnNCVkeHUkyvZV4>
Detroit562	NYLKR45qT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmXRTWM2OD1yLkCzPFczKM7:TR?=	NI\wbJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTJzNkSvK\|5USU6JRWK8M4E,
MONO-MAC-6	NEjqeoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHXkU2RKSzVyPUCuNFM5QTNizszN	NUDGeGhkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV{MU[0M{c,W0GQR1XSQE9iRg>?
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BT-474	NEHSXmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEjSTHhKSzVyPUCuNFcxPjFizszN	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVIyPjRxJ{7TRW5ITVJ:L3G+
HEC-1	NEDNU4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXvWdoROUUN3ME2wMlA4OTZzIN88US=>	NELXdXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTJzNkSvK\|5USU6JRWK8M4E,
NOMO-1	NVHr[\|IxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWqxbYR{UUN3ME2wMlA4OTd{IN88US=>	NILUXW89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTJzNkSvK\|5USU6JRWK8M4E,
KM-H2	NITZUJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWrYPVlKUUN3ME2wMlA4OjRzIN88US=>	NYj0RYVKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV{MU[0M{c,W0GQR1XSQE9iRg>?
EB2	NG\4[YNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M33EOGlEPTB;MD6wO\|I5PSEQvF2=	M4\vVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2OjF4ND:nQnNCVkeHUkyvZV4>
LU-99A	NUXjZXN[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MX7JR\|UxRTBwMEeyPFch\|ryP	NXS4b3FjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV{MU[0M{c,W0GQR1XSQE9iRg>?
WSU-NHL	M17hPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWXJR\|UxRTBwMEezNlkh\|ryP	M4nOOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2OjF4ND:nQnNCVkeHUkyvZV4>
Calu-1	NVzPWJhmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWLaO2lDUUN3ME2wMlA4OzN{IN88US=>	M2XWWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2OjF4ND:nQnNCVkeHUkyvZV4>
U-698-M	NYXTc2ZkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mo\xTWM2OD1yLkC3N\|gzKM7:TR?=	M{TMOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2OjF4ND:nQnNCVkeHUkyvZV4>
GI-ME-N	NWfMbopnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mo\MTWM2OD1yLkC3OFI3KM7:TR?=	MlrKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlUzOTZ2Lze+V2FPT0WUPD;hQi=>
T98G	NVqwbWNkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEWyUYhKSzVyPUCuNFc1OjFizszN	MoHZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlUzOTZ2Lze+V2FPT0WUPD;hQi=>
LS-513	M{XVe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnXaTWM2OD1yLkC3OFU3KM7:TR?=	NYfRO4I{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV{MU[0M{c,W0GQR1XSQE9iRg>?
UACC-257	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2fUemlEPTB;MD6wO\|UxPSEQvF2=	NXvlSnNoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV{MU[0M{c,W0GQR1XSQE9iRg>?
DK-MG	NX7ySphXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MoTLTWM2OD1yLkC3OVI3KM7:TR?=	NYTzbHFNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV{MU[0M{c,W0GQR1XSQE9iRg>?
CHP-126	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFf1OnZKSzVyPUCuNFc2PjVizszN	MmrBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlUzOTZ2Lze+V2FPT0WUPD;hQi=>
EW-11	M2LFbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYLLO3pVUUN3ME2wMlA4PTN3IN88US=>	NEfvWHI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTJzNkSvK\|5USU6JRWK8M4E,
Ramos-2G6-4C10	NXHYcHAxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGXvPFFKSzVyPUCuNFc3PDhizszN	NIrtdJU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTJzNkSvK\|5USU6JRWK8M4E,
Saos-2	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWPJR\|UxRTBwMEe1PVch\|ryP	NEX6NWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTJzNkSvK\|5USU6JRWK8M4E,
L-428	NHfHfXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Ml65TWM2OD1yLkC3O\|A1KM7:TR?=	NYP6UFd1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV{MU[0M{c,W0GQR1XSQE9iRg>?
HOP-92	Mn7wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUP4cnIyUUN3ME2wMlA4PzFzIN88US=>	M1nUVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2OjF4ND:nQnNCVkeHUkyvZV4>
PANC-08-13	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFrUPFJKSzVyPUCuNFc4OTZizszN	MlPDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlUzOTZ2Lze+V2FPT0WUPD;hQi=>
TUR	NHrWTnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVnEOHU5UUN3ME2wMlA4PzN\|IN88US=>	MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVIyPjRxJ{7TRW5ITVJ:L3G+
DMS-153	NVzrfXU6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVTJR\|UxRTBwMEe3N\|Uh\|ryP	M3T4d\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2OjF4ND:nQnNCVkeHUkyvZV4>
NCI-N87	MoewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoXDTWM2OD1yLkC3O\|k6KM7:TR?=	NI\JRmg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTJzNkSvK\|5USU6JRWK8M4E,
ESS-1	NFHxXnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIfTSVRKSzVyPUCuNFc5PjhizszN	NILDU4w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTJzNkSvK\|5USU6JRWK8M4E,
NCI-SNU-1	NILjVXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkXtTWM2OD1yLkC3PFg5KM7:TR?=	NELOTJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTJzNkSvK\|5USU6JRWK8M4E,
CP66-MEL	NX2yWm9XT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mo\3TWM2OD1yLkC3PFg4KM7:TR?=	NXnneWxCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV{MU[0M{c,W0GQR1XSQE9iRg>?
Calu-6	M{j5Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVnJR\|UxRTBwMEe5OlUh\|ryP	NHPzWXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTJzNkSvK\|5USU6JRWK8M4E,

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-ALK / ALK / p-AKT / AKT / p-ERK / ERK / TβRI / TβRII; PubMed: 23993685 Mol Oncol Cells were treated with or without the indicated doses of 17-DMAG or AUY-922 for 3 h. Changes in ALK-related signaling and TGF-b receptors were analyzed using Western blot analysis. The densitometry values were determined relative to control of H2228 after normalization to b-actin protein. E-cadherin / Cleaved PARP / Bim; PubMed: 23993685 Mol Oncol Cells were treated with crizotinib (1 mM), 17-DMAG (1 mM), or AUY-922 (1 mM) for the indicated times. Cell lysates were subjected to Western blot analysis using the indicated antibodies. The densitometry values were determined relative to control after normalization to b-actin protein. HSP70 / Grp94 / Grp78 / p-eIF2α / CHOP / IRE1α / p-JNK; PubMed: 24796583 Oncotarget CCA cells were incubated with 0.5 uM NVP-AUY922 for 0, 2, 4, 8, 16, and 24 h. Whole cell lysates were subjected to western blot analysis for HSP70, Grp94, Grp78, p-eIF2α, CHOP, IRE1α, and phosphor-JNK. β-Actin was used as the loading control. CDK4 / HMGA2 ; PubMed: 26893968 PeerJ HCT116 cells were treated with NVP-AUY922 at the indicated concentrations for 48 hours. Cell extracts were analyzed using Western blotting with the antibodies for CDK4, Hsp70, and HMGA2, respectively.	23993685 24796583 26893968
Growth inhibition assay	Cell viability; PubMed: 26893968 PeerJ Cell viability assay was performed to determine the of HCT116 cells treated with various concentrations of NVP-AUY922 for 48 hours. p < 0.05, p < 0.01, **p < 0.001. All experiments were performed in three independent experiments.	26893968

体内研究

使用NVP-AUY922可引起强的抗癌反应，可抑制HSC-2移植瘤模型中p-Akt和VEGF的表达。^[2] 在12种实验肿瘤中观察到5种肿瘤衰退。体重降低<5%，且与HSP90相关的生物标签明显改变。BT474中, ERBB2完全缺失，ERα耗尽，且CDK4和磷酸化ERK1/2降低。^[3]

激酶实验：^[3]	- 合并激酶实验: NVP-AUY922溶解在DMSO中，浓度为10mM。通过作用于HSP90α, HSP90β, GRP94, TRAP-1, HSP72,和拓扑异构酶II评估NVP-AUY922的活性。
细胞实验：^[1]	- 合并 Cell lines: 人类胃癌细胞系NCI-N87 Concentrations: 1 μM Incubation Time: 3天 Method: 人类胃癌细胞NCI-N87按5-7×10³密度接种在96孔板中，每孔接种50ul，在37^oC下温育24小时，然后用NVP-AUY922处理1到3天。实验处理后，使用MTT实验测细胞活力，用酶标仪分析。 (Only for Reference)
动物实验：^[3]	- 合并 Animal Models: 携带WM266.4人类黑色素移植瘤的雌性NCr无胸腺鼠 Dosages: 50 mg/kg Administration: 静脉注射或腹腔注射 (Only for Reference)

参考文献

溶解度 (25°C)

体外	DMSO	93 mg/mL warmed (199.76 mM)
	Water	Insoluble
	Ethanol	''31 mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download Luminespib (NVP-AUY922) SDF

分子量	465.54
化学式	C₂₆H₃₁N₃O₅
CAS号	747412-49-3
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	AUY-922, VER-52296

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

临床试验信息 (data from https://clinicaltrials.gov, updated on 2022-01-17)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT01772797	Completed	Drug: LDK378\|Drug: AUY922	Anaplastic Lymphoma Kinase (ALK)\|Non-small Cell Lung Cancer	Novartis Pharmaceuticals\|Novartis	June 2013	Phase 1
NCT01752400	Completed	Drug: AUY922	Non Small Cell Lung Cancer	Massachusetts General Hospital	January 2013	Phase 2
NCT01613950	Completed	Drug: AUY922\|Drug: BYL719	Stomach Neoplasms Esophageal Neoplasms Metastatic Gastric Cancer Mutated PI3KCA Protein Overexpressed HER2 Protein	Novartis Pharmaceuticals\|Novartis	December 2012	Phase 1
NCT01484860	Terminated	Drug: AUY922	Adenocarcinoma of the Pancreas\|Metastatic Disease	University Health Network Toronto\|Novartis Pharmaceuticals	January 2012	Phase 2
NCT01402401	Terminated	Drug: AUY922\|Drug: Trastuzumab	Advanced Gastric Cancer	Novartis Pharmaceuticals\|Novartis	November 2011	Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

HSP (HSP90) Signaling Pathway Map

HSP (HSP90) Inhibitors with Unique Features

选择性强的HSP90抑制剂

NVP-BEP800 : HSP90β-selective, IC50=58 nM.
活性最高的HSP90抑制剂

KW-2478 : HSP90, IC50=3.8 nM.
用于临床的HSP90抑制剂

17-AAG (Tanespimycin) : Phase III for Gastrointestinal Stromal Tumors.
最新的HSP90抑制剂

XL888 : ATP-competitive inhibitor of HSP90 with IC50 of 24 nM.

研究领域

产品类型

定制您的化合物库

Luminespib (NVP-AUY922)

客户使用Selleck生产的Luminespib (NVP-AUY922)发表文献97篇：

产品安全说明书

HSP (HSP90)抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download Luminespib (NVP-AUY922) SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

临床试验信息 (data from https://clinicaltrials.gov, updated on 2022-01-17)

技术支持

HSP (HSP90) Signaling Pathway Map

HSP (HSP90) Inhibitors with Unique Features

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