Olaparib (AZD2281)

For research use only. Not for use in humans.

目录号:S1060 别名: Ku-0059436 中文名称:奥拉帕尼

Olaparib (AZD2281) Chemical Structure

CAS No. 763113-22-0

Olaparib (AZD2281, KU0059436)是选择性的PARP1/2抑制剂,IC50为5 nM/1 nM,其对PARP1/2的作用比对Tankyrase-1效果高300倍。在BRCA突变的细胞中,Olaparib可以显著地诱导线粒体自噬相关的细胞自噬。

规格 价格 库存 购买数量  
RMB 571.54 现货
RMB 1219.52 现货
RMB 3019.32 现货
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客户使用Selleck生产的Olaparib (AZD2281)发表文献586篇:

产品安全说明书

PARP抑制剂选择性比较

生物活性

产品描述 Olaparib (AZD2281, KU0059436)是选择性的PARP1/2抑制剂,IC50为5 nM/1 nM,其对PARP1/2的作用比对Tankyrase-1效果高300倍。在BRCA突变的细胞中,Olaparib可以显著地诱导线粒体自噬相关的细胞自噬。
特性 Olaparib是第一批PARP抑制剂之一。
靶点
PARP2 [1]
(Cell-free assay)
PARP1 [1]
(Cell-free assay)
1 nM 5 nM
体外研究

Olaparib是PARP抑制剂,也作用于BRCA1或BRCA2突变。Olaparib对端锚(聚合)酶-1作用效果不大,IC50值大于。Olaparib浓度为30-100 nM作用于SW620细胞,使PARP-1失活。与BRCA1和BRCA2充足细胞系(Hs578T,MDA-MB-231,T47D)相比,BRCA1缺陷细胞系(MDA-MB-463和HCC1937)对Olaparib过分敏感[1] Olaparib抑制PARP,阻断碱基切除修复,导致KB2P细胞对Olaparib强烈敏感。结果导致在DNA复制时由单链断裂转变为双链断裂,由此激活BRCA2依赖的重组途径。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KP3.33 NETJNVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PsR|Qh\A>? NEPmc4hKSzVyPUWuO|A2KCEQvF2g NY\o[mZpOTh3NUm2NVM>
KP6.3 NITpUWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUi0JIQ> MlX0TWM2OD1zMD60Nlgh|ryPIB?= MXSxPFU2QTZzMx?=
KP7.7 Ml25S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XTS|Qh\A>? NHnOR3FKSzVyPUW3JI5OKA>? MXSxPFU2QTZzMx?=
KB2P3.4 M1fqW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTZOEBl M1TjcGlEPTB;MUK0JG0h MXuxPFU2QTZzMx?=
KB2P1.21 NVHzfnBqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGn6WIQ1KGR? M2XyfGlEPTB;OEmwO{BvVSB? NEDSbngyQDV3OU[xNy=>
U373-MG M{nIRWN6fG:2b4jpZ{BCe3OjeR?= MXOxJO69VSB? MVqyOEBp MXzJcoNz\WG|ZYOgdoFlcWG2aX;uJJNmdnOrdHn2bZR6 NILqcXoyQDl3NEexNi=>
T98G MVzDfZRwfG:6aXOgRZN{[Xl? M3X0c|Eh|ryPIB?= NG\HTo8zPCCq NUm3O|JvUW6lcnXhd4V{KHKjZHnheIlwdiC|ZX7zbZRqfmm2eR?= MnPHNVg6PTR5MUK=
U87-MG NXzGe25mS3m2b4TvfIlkKEG|c3H5 M3y5UVEh|ryPIB?= MmfWNlQhcA>? M175cmlv[3KnYYPld{Bz[WSrYYTpc44he2Wwc3n0bZZqfHl? M3z1e|E5QTV2N{Gy
UVW MYHDfZRwfG:6aXOgRZN{[Xl? NYP1coZGPTByIH7N MlzuNlQhcA>? M{W2SWlv[3KnYYPld{Bz[WSrYYTpc44he2Wwc3n0bZZqfHl? M1y0V|E5QTV2N{Gy
HeLa NV3wfJZ2TnWwY4Tpc44hSXO|YYm= MYq1NFAhdk1? MlPUOEBp M2XwWGNifXOnczDhJI1w\GW|dDDk[YxigSCrbjDy[YpwcW6rbnegc4YhemGmaXH0bY9vNWmwZIXj[YQhTE6DIHLy[YFsew>? MXWxPFk2PDdzMh?=
HeLa MYPGeY5kfGmxbjDBd5NigQ>? M3\qcVEh|ryPIB?= MnqwNlQhcA>? M1zVe2VvcGGwY3XzJJJi\GmjdHnvck1qdmS3Y3XkJHMueGijc3WgZZJz\XO2 M2TRVFE5QTV2N{Gy
T98G M17VZmZ2dmO2aX;uJGF{e2G7 MoSyNUDPxE1i Mn;2NlQhcA>? NUf0PVl[TW6qYX7j[ZMhemGmaXH0bY9vNWmwZIXj[YQhWy2yaHHz[UBienKnc4S= NIe2[3IyQDl3NEexNi=>
L3 NWm2VYg{S3m2b4TvfIlkKEG|c3H5 MWK1JO69VSB? NYjy[2c4QTZiaB?= MULEUXNQ MonQV4lodmmoaXPhcpRtgSCrbnjpZol1eyClZXzsJJN2en[rdnHs NUL5ZppIOjBzMkS0OVk>
Granta-519 MkPNR5l1d3SxeHnjJGF{e2G7 MV61JO69VSB? NIrTeoY6PiCq NETDRXpFVVOR MlzWV4xq\2i2bImgbY5pcWKrdIOgZ4VtdCC|dYL2bZZidA>? MmPxNlAyOjR2NUm=
BT MmXHR5l1d3SxeHnjJGF{e2G7 M4LVOVUh|ryPIB?= MV25OkBp M2C2PWROW09? Mk\iV4xq\2i2bImgbY5pcWKrdIOgZ4VtdCC|dYL2bZZidA>? M1Pn[|IxOTJ2NEW5
UPN2 MonXR5l1d3SxeHnjJGF{e2G7 M4nP[FUh|ryPIB?= NFS2[GM6PiCq MlTxSG1UVw>? NUThUVViW2yrZ3j0cJkhcW6qaXLpeJMh[2WubDDzeZJ3cX[jbB?= M4foSlIxOTJ2NEW5
HBL-2 NFnVO4FEgXSxdH;4bYMhSXO|YYm= MWe1JO69VSB? MmrvPVYhcA>? MmfBSG1UVw>? NFjBdmpUdGmpaITsfUBqdmirYnn0d{Bk\WyuIIP1dpZqfmGu NXXacXl7OjBzMkS0OVk>
JVM-2 MYTDfZRwfG:6aXOgRZN{[Xl? MYe1JO69VSB? M3XHNFk3KGh? Ml;VSG1UVw>? NX\hXoM5W2yrZ3j0cJkhcW6qaXLpeJMh[2WubDDzeZJ3cX[jbB?= MnX2NlAyOjR2NUm=
Z138 M3PD[mN6fG:2b4jpZ{BCe3OjeR?= MnHlOUDPxE1i M1ThPVk3KGh? MkXmSG1UVw>? NHTZeXlUdGmpaITsfUBqdmirYnn0d{Bk\WyuIIP1dpZqfmGu M2j0U|IxOTJ2NEW5
RWPE M2fwPGlvfmG|aY\lJGF{e2G7 NXrHXmloOjVizszN NHrYSVY1QCCq M13UUWROW09? Mo\LV4lodmmoaXPhcpRtgSC{ZXT1Z4V{KEWURz3kdol3\W5iY3XscEBqdn[jc3nvci=> MYOyNVU4PTh4NR?=
VCaP M2O5fWlvfmG|aY\lJGF{e2G7 MnTPNlUh|ryP NIK5VIg1QCCq NXyzbJFETE2VTx?= MVTTbYdvcW[rY3HueIx6KHKnZIXj[ZMhTVKJLXTybZZmdiClZXzsJIlvfmG|aX;u MmTvNlE2PzV6NkW=
Mouse H2AX−/− ES Cells NFqw[VBEgXSxdH;4bYMhSXO|YYm= Mme1Nk42KM7:TR?= MXWyNEBp Mo\BV4lodmmoaXPhcpRtgSCrbnjpZol1eyClZXzsJJN2en[rdnHs MYKyN|M2PTR6OR?=
Mouse ATM−/− ES Cells Mn;HR5l1d3SxeHnjJGF{e2G7 MVGyMlUh|ryP NUnHbW9iOjBiaB?= MojUV4lodmmoaXPhcpRtgSCrbnjpZol1eyClZXzsJJN2en[rdnHs NFzuc|IzOzN3NUS4PS=>
H1650 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjoZowzOCEQvF2= M1HK[|E1PCCq NUHiRng5UUN3ME2xOU41PyEQvF2= MVmyN|I{QThyOR?=
H1650PTEN+ MlzjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HPTVIxKM7:TR?= NUjXXldzOTR2IHi= NV3Y[lZUUUN3ME21NE45OyEQvF2= MVWyN|I{QThyOR?=
PC-9 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfJNlAh|ryP NUfNUIFOOTR2IHi= MV7JR|UxRTVwOEig{txO NUnmV5B2OjN{M{m4NFk>
PC-9PTEN− MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HmS|IxKM7:TR?= NFrrbYoyPDRiaB?= MVXJR|UxRTZwNUKg{txO NYfVcFkzOjN{M{m4NFk>
MDA-MB-231 NHfDVllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYqxbG15PSCmYYm= NVH0clB{UUN3ME22Mlkh|ryP M4G5dFI{PzZyNEm2
MDA-MB-468 NHTL[YlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjZbYpCPSCmYYm= M4ew[WlEPTB;NT6wJO69VQ>? NHvYSpgzOzd4MES5Oi=>
BT20 MlPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfpOUBl[Xl? NH[0U3hKSzVyPUeuO{DPxE1? NYLSbG8xOjN5NkC0PVY>
HCC1143 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXydmRwPSCmYYm= NYfPd2VNUUN3ME2xNU4yKM7:TR?= M2q0elI{PzZyNEm2
HCC1937 M1LpR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYG1JIRigQ>? MYHJR|UxRTF{Lk[g{txO M{jV[lI{PzZyNEm2
Hs578t M{f3Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\oOUBl[Xl? MYnJR|UxRTVwNjFOwG0> Mm\FNlM4PjB2OU[=
Hs578t(si) MmTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXUOVA2KGSjeR?= MmfpTWM2OD15LkWg{txO NWrGdFFxOjN5NkC0PVY>
BT474 NV;H[3A2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn30OUBl[Xl? MVHJR|UxRTF7Lkig{txO NWjSeoxwOjN5NkC0PVY>
JIMT1 NI\KdmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXUZm02KGSjeR?= MWnJR|UxRTdwNzFOwG0> NFzQdmczOzd4MES5Oi=>
SKBR3 M3HST2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHTcYtoPSCmYYm= MkTkTWM2OD1zMT6xJO69VQ>? NYi3coFDOjN5NkC0PVY>
SUM159 NFj6VmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHv2eG42KGSjeR?= M4nMRWlEPTB;ND6yJO69VQ>? NEfUTowzOzd4MES5Oi=>
CAMA1 MkXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHFOUBl[Xl? MUTJR|UxRTF3Lkig{txO NWnGTYRNOjN5NkC0PVY>
MCF7 MljMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDMbpVnPSCmYYm= NHPrTmJKSzVyPUWuPEDPxE1? NVewNYZzOjN5NkC0PVY>
T47D NETaTG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmiyOUBl[Xl? NH;kc|lKSzVyPUmuOkDPxE1? MWOyN|c3ODR7Nh?=
HCT116 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXG2dpA4OTByIN88US=> NH[1V5c1QCCq NVTDcplvTE2VTx?= NGjXR|JKSzVyPUKuOUDPxE1i NXfqN5NtOjR3N{e5OFE>
SW1116 NIXE[HNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWWxNFAh|ryP MWW0PEBp MX3EUXNQ MmjyTWM2OD1zMECg{txO M4ixWVI1PTd5OUSx
HT29 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7ZNVAxKM7:TR?= NWm5RVVCPDhiaB?= MnrESG1UVw>? NWe3RmtTUUN3ME2xOE44KM7:TR?= NHXjdmszPDV5N{m0NS=>
LoVo MoL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrWNVAxKM7:TR?= M4PEUVQ5KGh? MWPEUXNQ M1fBbmlEPTB;MUOuOEDPxE1? NUD3SpZIOjR3N{e5OFE>
HCT-15 MnLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWixNFAh|ryP NXTUUmZPPDhiaB?= NHn6WGdFVVOR NGjmSVlKSzVyPUGwJO69VQ>? MoTJNlQ2Pzd7NEG=
SW48 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkH4NVAxKM7:TR?= NXPWeYI1PDhiaB?= MXPEUXNQ MWnJR|UxRTlwNTFOwG0> Mo\DNlQ2Pzd7NEG=
C-1 NILMbmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\DVFExOCEQvF2= MoPmOFghcA>? NHuzd5hFVVOR Ml\kTWM2OD15Lk[g{txO NGLleGczPDV5N{m0NS=>
RKO MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmH0NVAxKM7:TR?= NFPnclg1QCCq NGDPZpZFVVOR MoTnTWM2OD13Lkmg{txO MViyOFU4Pzl2MR?=
HCT116 Mn33S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVuwSFU4OTByIN88US=> MkjIOFghcA>? M3PmW2ROW09? NY\YdpF2WG:2ZX70bYF1\XNiU16tN|gh[3m2b4TvfIlkcXS7IB?= M4LqflI1PTd5OUSx
SW1116 NV3KNm5KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTQU4QyODBizszN NX7MUGlQPDhiaB?= M3zUT2ROW09? NGnhWmFRd3SnboTpZZRmeyCVTj2zPEBkgXSxdH;4bYNqfHli MYCyOFU4Pzl2MR?=
HT29 M1m3TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDFPZEyODBizszN NE\OdHk1QCCq MWXEUXNQ MnfZVI91\W62aXH0[ZMhW05vM{igZ5l1d3SxeHnjbZR6KA>? NX3VR3ljOjR3N{e5OFE>
LoVo NEWxXWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYGxNFAh|ryP M1LoT|Q5KGh? MX;EUXNQ MnOwVI91\W62aXH0[ZMhW05vM{igZ5l1d3SxeHnjbZR6KA>? NHr1Z4EzPDV5N{m0NS=>
SW48 NGTMNmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XPOlExOCEQvF2= NYTMSIp7PDhiaB?= NIrwfGZFVVOR MYjQc5RmdnSrYYTld{BUVi1|ODDjfZRwfG:6aXPpeJkh M2XtdFI1PTd5OUSx
C-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHWb3AyODBizszN M2XLWFQ5KGh? NV:5O5A4TE2VTx?= NEK2fIVRd3SnboTpZZRmeyCVTj2zPEBkgXSxdH;4bYNqfHli NEDGRnUzPDV5N{m0NS=>
RKO MmfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTONVAxKM7:TR?= MXG0PEBp NF3V[nNFVVOR M1TLcHBwfGWwdHnheIV{KFOQLUO4JIN6fG:2b4jpZ4l1gSB? M2T3RlI1PTd5OUSx
HCT116 NGC1SGdHfW6ldHnvckBCe3OjeR?= MkTGNVAhdk1? MnXwNVIhcA>? NUToPZFsTE2VTx?= M{jXRWlv[3KnYYPld{BFVkFiZH;1ZoxmNXO2cnHu[EBjemWja4OgbY5lfWOnZDDifUBUVi1|OB?= M4jzTFI1PTd5OUSx
HT29 NGDveWhHfW6ldHnvckBCe3OjeR?= M3jDOFExKG6P M37HSFEzKGh? NY\5R|FUTE2VTx?= MYfJcoNz\WG|ZYOgSG5CKGSxdXLs[U1{fHKjbnSgZpJm[Wu|IHnu[JVk\WRiYomgV24uOzh? MUGyOFU4Pzl2MR?=
TE-6 NEKzOZpHfW6ldHnvckBCe3OjeR?= NH3IOoQ2KM7:TTC= MUWxNkBp NFTnWoFFVVOR MVLJcoR2[2W|IFeyM20h[XK{ZYP0 MYSyOFIyQTF4NB?=
TE-6 NVvQSGtUTnWwY4Tpc44hSXO|YYm= NXTqRWtnPSEQvF2g NXTDcm92OjRiaB?= MXjEUXNQ NFjjb3BKdmO{ZXHz[ZMhcW5iZH;1ZoxmKHO2cnHu[EBjemWja4OgLGRUSnNr MlPzNlQzOTlzNkS=
Hep3B NYjtOYtIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HlflQxKM7:TTC= M1raZlczKGh? NVjRXYQ4TE2VTx?= M1nLfnN6dmW{Z3nzeIlk[WyueTDpcohq[mm2czDj[YxtKGe{b4f0bEB4cXSqIFTIUWVS Mnf3NlUxPzJ5NUK=
Huh7 NV3KSlVmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUG0NEDPxE1i MYW3NkBp NYLWOXNKTE2VTx?= MYnTfY5memerc4TpZ4FtdHliaX7obYJqfHNiY3XscEBoem:5dHige4l1cCCGSF3FVS=> MnHKNlUxPzJ5NUK=
Hep3B MXLGeY5kfGmxbjDBd5NigQ>? MU[0NEDPxE1i M3TTcVI1KGh? M3vybmROW09? NIf3eHVKdmS3Y3XzJHJQWyCycn;keYN1cW:wIIfpeIghTEiPRWG= MnS0NlUxPzJ5NUK=
Huh7 MYrGeY5kfGmxbjDBd5NigQ>? M2XTN|QxKM7:TTC= NVjnfmRxOjRiaB?= MkXNSG1UVw>? MV7JcoR2[2W|IGLPV{Bxem:mdXP0bY9vKHerdHigSGhOTVF? M2[1T|I2ODd{N{Wy
Hep3B M1j4R2Z2dmO2aX;uJGF{e2G7 M{XEZ|QxKM7:TTC= MkjrNlQhcA>? NHrLWFZFVVOR NGPWZXlKdmS3Y3XzJINmdGxiYYX0c5Bp[We7IIfpeIghTEiPRWG= NGi4dFAzPTB5Mke1Ni=>
Huh7 NWXIe4lvTnWwY4Tpc44hSXO|YYm= NW\QeHV3PDBizszNJC=> MWOyOEBp M3nMbWROW09? MX3JcoR2[2W|IHPlcIwh[XW2b4DoZYd6KHerdHigSGhOTVF? NVX3cW5lOjVyN{K3OVI>
SGC-7901 NYPOd2x{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3DN|DDqM7:TR?= NIHa[Wk1QCCq MYDEUXNQ M2\VPGJtd2OtIH;4ZYxqeGyjdHnuMYlv\HWlZXSgZ4VtdCCmZXH0bC=> NGDJPHAzPTd4N{C3Oi=>
COLO-800 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4WxVmlEPTB;MD60OFE3PCEQvF2= MoLSV2FPT0WU
EoL-1- MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFn4WnZKSzVyPUCuOVY1PDZizszN NIPVPWRUSU6JRWK=
NCI-H209 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFn5PZBKSzVyPUCuPVE2PTZizszN M{PkZnNCVkeHUh?=
ES1 MkLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVT4UlRXUUN3ME2xMlEyPDB6IN88US=> M3\NRXNCVkeHUh?=
NKM-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTRTWM2OD1zLkK1N|Q4KM7:TR?= NIW2fZRUSU6JRWK=
NTERA-S-cl-D1 Mn;jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTwU3JsUUN3ME2xMlM{OzRzIN88US=> NIHSXJhUSU6JRWK=
MHH-ES-1 Mn7LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\TVmlEPTB;MT62NlA3PyEQvF2= Ml\jV2FPT0WU
ES8 MoLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3e0XGlEPTB;MT63NlQyPCEQvF2= NHnoO2lUSU6JRWK=
NCI-H720 NEHmW5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnWXFN[UUN3ME2yMlIxPjl7IN88US=> NH\aV4tUSU6JRWK=
EW-3 M4W5S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHz4RXhKSzVyPUKuNlc2OzRizszN MYHTRW5ITVJ?
D-566MG NHuyR25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XpcGlEPTB;Mj60OFU3QCEQvF2= MVzTRW5ITVJ?
697 NFzMWJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\1TWM2OD1{Lki0NVc{KM7:TR?= NUf0[nFvW0GQR1XS
ES5 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DsdmlEPTB;Mj64PFE5QSEQvF2= NYj1XnpTW0GQR1XS
COLO-684 NY\WZZp{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnuTWM2OD1|LkWxOlk3KM7:TR?= MXfTRW5ITVJ?
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