Panobinostat (LBH589)

目录号:S1030 别名: NVP-LBH589

Panobinostat (LBH589) Chemical Structure

Molecular Weight(MW): 349.43

Panobinostat (LBH589)是一种新型的,广谱HDAC抑制剂,无细胞试验中IC50为5 nM。Phase 3。

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客户购买Selleck的此次产品后发表的文献48篇:

客户使用该产品的12个实验数据:

  • (G) A375 parental and BRAFi-resistant ex vivo clones were treated with a panel of HDACi (1 μM vorinostat, 0.5 μM belinostat, and 6 nM panobinostat) in single treatment or in combination with 1 μM vemurafenib in a long-term colony formation assay.

    Cell, 2018, 173(6):1413-1425. Panobinostat (LBH589) purchased from Selleck.

    LSD1 and HDAC inhibitors exhibit synergistic growth inhibition. Cells were simultaneously treated with pargyline or HDAC inhibitors for 48 h.

     

     

    Breast Cancer Res Treat 2012 131, 777-789. Panobinostat (LBH589) purchased from Selleck.

  • Using CRISPR-Cas9 technology, ERα was silenced at the genomic level in ECC1 cells. Ishikawa, parental ECC1 cells and individual ESR1 KO ECC1 clones were treated with 20 nM LBH589 for 24 hr. Expression of ERα, PR, FOXO1, and Myc were evaluated by Western blotting. β-actin serves as a loading control.

    PLoS One, 2016, 11(2):e0148912.. Panobinostat (LBH589) purchased from Selleck.

    HDACIs That Simultaneously Inhibit HDACs 1 and 6 Showed Greater Antileukemic Activities than HDACIs that Don’t at Cmax Concentrations. THP-1 cells were treated with LBH-589, PXD101, SAHA, VPA, MS-275 and MGCD0103 at Cmax concentrations for 3 h and 24 h, respectively. The cells post 3 h treatments were washed three times with complete medium and divided into two halves. One half of the cells was resuspended in complete media and cultured for up to 24 h to determine the effects of the 3 h treatments on cell proliferation and apoptosis. The other half of the cells was used to prepare whole cell lysates. Whole cell lysates from the 3 h and 24 h treatments were extracted and subjected to Western blots probed by anti-ac-tubulin or –b-actin antibody (panels A&B), or subjected to HDAC1 enzymatic assays post IP as described in the Materials and Methods (Panels C&D). The effects of the 3 h and 24 h HDACI treatments on cell proliferation, as reflected by percent decrease of live cells relative to untreated cells (panel E), and apoptosis (panel F) were determined by flow cytometry analysis as described in the Materials and Methods.

     

     

    PLoS One 2011 6, e17138. Panobinostat (LBH589) purchased from Selleck.

  • Induction of DNA Damage and Bim Is Critical for HDACI-Induced Apoptosis in Pediatric AML Cells. THP-1 cells were treated with the HDACIs at Cmax concentrations for 3 (panel A) and 24 h (panel B), respectively. Whole cell lysates were extracted and subjected to Western blots probed by anti-p21, -c-Myc, -cH2AX, -Bim, or -b-actin antibody.

     

     

    PLoS One 2011 6, e17138. Panobinostat (LBH589) purchased from Selleck.

    Cell death induction by LBH589 as a single agent was detected in control or MTDH knockdown Hec50co cells. After 3 days, cell death was determined by the WST-1 method.

    PLoS One 2011 6, e20920. Panobinostat (LBH589) purchased from Selleck.

  • Expression of pro-/anti-apoptosis genes. Control or MTDH knockdown Hec50co cells were treated for 24 hours with vehicle control, 20 nM LBH589, 25 ng/ml TRAIL or LBH589 and TRAIL at the concentrations noted. Lysates were collected. Expression of DR4, DR5, and apoptosis related caspase-3, caspase-8, PARP-1, BID, FLIP, XIAP, Bim, MCL-1 and BCL-XL was analyzed by Western blotting.

    PLoS One 2011 6, e20920. Panobinostat (LBH589) purchased from Selleck.

    p53(+/+) and (/) HCT116 cells were treated with TSA (1–5 lM),LBH589 (2–5 lM), valproate (2.5–5 mM), MS-275 (20 lM) and sodium butyrate (2 mM). TAp63 expression was compared in both cell lines after 24 h of treatment. Consistent with the above data, all HDAC inhibitors failed to induce significant levels of TAp63 in p53(/) HCT116 cells.

     

     

    Biochem Bioph Res Co 2009 391, 1748-1751. Panobinostat (LBH589) purchased from Selleck.

  • Effect of panobinostat on the viability of cervical cancer cells. HeLa (A) and SiHa (B) cells were treated with increasing concentrations of panobinostat for 24, 48 and 72 h. Cell viability was determined by MTT assay. The results are presented as percentage; calculated from the reduction in cell viability at a given concentration of drug compared to the untreated control (untreated control being 100%). The IC5072h values were calculated from sigmoidal dose-response curves generated in Prism 5.0 (GraphPad). (C) Cytotoxic effects of panobinostat on HeLa and SiHa cells measured at 72 h and expressed as% cell death. Each value is the mean ± SD of three independent experiments performed in triplicates.

    Biomed Pharmacother, 2016, 84:1393-1405. Panobinostat (LBH589) purchased from Selleck.

    Western blot analysis of Acetyl-H3 and H3. 0-10μM Panobinostat was added.

    Dr.Zhang of Tianjin Medical University. Panobinostat (LBH589) purchased from Selleck.

  • HDAC inhibitors induce p63a expression (A) HCT116 cells were treated with TSA (1 lM), LBH589 (2 lM), valproate (2.5 mM), MS-275 (20 lM) and sodium butyrate(2 mM) for 24 h. Expression of p63 was assessed by Western blotting with the H129 pan-anti-p63 antibody. Although TSA and LBH589 induced p63 efficiently, valproate, MS-275 and sodium butyrate were much less efficient. The lower panel shows the actin loading control. Arrow indicates TAp63. (B) The HDAC inhibitors used in this study are shown, grouped according to their structure and with their HDAC specificity. The efficiency of TAp63 expression is shown in the last column.

     

     

    Dr. Berna S. Sayan of Leicester University. Panobinostat (LBH589) purchased from Selleck.

    U266 and KMS-11 were treated with 20 nM panobinostat for 48 h followed by Western blot analysis. Actin served as a loading control. Nine (U266) and 3 (KMS-11) biologically independent experiments were performed. To determine the expression of PPP3CA mRNA in treated cells for 24 h, we performed relative quantification real-time PCR (n = 6). Four (U266) and 2 (KMS-11) biologically independent experiments were performed.

    JCI Insight, 2016, 1(5):e85061. Panobinostat (LBH589) purchased from Selleck.

产品安全说明书

HDAC抑制剂选择性比较

生物活性

产品描述 Panobinostat (LBH589)是一种新型的,广谱HDAC抑制剂,无细胞试验中IC50为5 nM。Phase 3。
靶点
HDAC (MOLT-4 cells) [1] HDAC (Reh cells) [1]
5 nM 20 nM
体外研究

LBH589诱导MOLT-4和Reh细胞凋亡,这种作用具有时间和剂量依赖性。而且,LBH589作用于MOLT-4细胞比作用于Reh细胞更有效。LBH589明显阻止MOLT-4 和Reh细胞的生长,处理48小时,具有剂量依赖性。与对照组细胞相比,用LBH589处理的细胞,在细胞周期的G2/M期的细胞数量增多2到3倍。LBH589与组蛋白H3K9和H4K8的乙酰化作用相关,LBH589也降低c-Myc的表达水平,具有剂量依赖性。LBH589也增强p21的表达水平。最低剂量的LBH589(10 nM)处理Reh细胞,最初增强c-Myc的表达水平,之后一直降低c-Myc的表达水平。此外,LBH589促进mRNA水平的促凋亡和DNA修复基因的大量增多。在GADD45G启动子作用下,LBH589诱导乙酰化的组蛋白H3 和H4水平的增多。[1]此外, LBH589抑制非小细胞肺癌细胞系生长,如人类H1299,L55和A549,IC50分别为5,11和30 nM;间皮瘤细胞生长,如人类OK-6和 Ok-5,IC50分别为5和7 nM;及小细胞肺癌细胞系生长,如人类RG-1和LD-T,IC50分别为4和5 nM。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HT29 M1rt[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrDTGgxNTFyIN88US=> NXq4N2xmOC12IHS= Mmn6bY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYn;0bEB1cW2nLTDhcoQh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{ MViyOlcxOjd6NB?=
HepG2 NUPzV|JwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmW5NE0yOCEQvF2= M4jxZ|AuPCCm Mon3bY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYn;0bEB1cW2nLTDhcoQh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{ NXn3UJpROjZ5MEK3PFQ>
HT29 MnvuSpVv[3Srb36gRZN{[Xl? M3XlOFUxyqCwTR?= NX7BN4czOjRvN{KgbC=> MlXZbY5lfWOnZDDhZ5RqfmG2aX;uJI9nKGOjc4Dhd4UhOyCjZoTldkA1QMLiaNMg MUGyOlcxOjd6NB?=
HepG2 MnTkSpVv[3Srb36gRZN{[Xl? MX21NOKhdk1? MmHINlQuPzJiaB?= MXTpcoR2[2WmIHHjeIl3[XSrb36gc4Yh[2G|cHHz[UA{KGGodHXyJFI1yqCqwrC= MVWyOlcxOjd6NB?=
HCC827 MnqyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1X0V|UwPy53L{GwJI5O MWi3NuKhcA>? MoTuSG1UVw>? NWC3WWZF\W6qYX7j[ZMhfGinIHHueIlxem:uaX\ldoF1cX[nIHXm[oVkfCCxZjDldoxwfGmwaXK= NHO2TZYzPjZ5NUS4OC=>
A549  MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknCNVAwOTVxMkCgcm0> MmTOO|LDqGh? M131TmROW09? Mkez[Y5p[W6lZYOgeIhmKGGwdHnwdo9tcW[ncnH0bZZmKGWoZnXjeEBw\iCncnzveIlvcWJ? MXKyOlY4PTR6NB?=
NCI-H460  MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvRNVAwOjBxM{Cgcm0> NYPrWnVJPzMEoHi= MlHSSG1UVw>? M2LWZoVvcGGwY3XzJJRp\SCjboTpdJJwdGmoZYLheIl3\SCnZn\lZ5Qhd2ZiZYLsc5Rqdmmk NF\LN|gzPjZ5NUS4OC=>
J89GFP M1jxUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHEUXNQyqB? NEn1[GtGSzVyPUS5Mlg2KMLzIEGyMlY2KG6P M1LybFI3PTZ|NU[4
THP89GFP MnqxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\EUXNQyqB? MV\FR|UxRTF7LkO0JOKyKDZwNEOgcm0> NEfCXo0zPjV4M{W2PC=>
SK-NEP-1 MoLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYH2[2RTOC5yMfMAl|ExNjBizszN MVqyOEBp MYPEUXNQyqB? NVS4WGp2UUN3ME23Ok4{PCCwTR?= M4TueFI3OTd4MkG5
G401 M4rEVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULRTm82OC5yMfMAl|ExNjBizszN MYOyOEBp M1HSTGROW00EoB?= NF;sNoJKSzVyPUG0N{4xOiCwTR?= NVfzO41NOjZzN{[yNVk>
SK-NEP-1 NF32Vo1E\WyuIG\pZYJqdGm2eTDBd5NigQ>? MnH6OVAhdk1? M{jkOlHjiJN2IHS= M3jHSmROW00EoB?= MUPy[YR2[2W|IHPlcIwhe3W{dnn2ZYwhcW5iYTD0bY1mKGSncHXu[IVvfCCvYX7u[ZI> NY[5VYJbOjZzN{[yNVk>
G401 NWPWOFNyS2WubDDWbYFjcWyrdImgRZN{[Xl? NYj6S2RjPTBibl2= Mof3NgKBmzRiZB?= NUHmR3RwTE2VT9Mg MWjy[YR2[2W|IHPlcIwhe3W{dnn2ZYwhcW5iYTD0bY1mKGSncHXu[IVvfCCvYX7u[ZI> MlPXNlYyPzZ{MUm=
SK-NEP-1 MoHlRZBweHSxc3nzJGF{e2G7 NFjQOHQ2OC9zMECgcm0> NVX6VFRjOjRiaB?= MV\EUXNQyqB? NYHkeFFIcW6mdXPld{Bk\WyuIHHwc5B1d3OrczDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= M3nWNVI3OTd4MkG5
G401 M1L0ZWFxd3C2b4Ppd{BCe3OjeR?= NG[3dlU2OC9zMECgcm0> M3\vZlI1KGh? NGr2[WZFVVORwrC= MnfWbY5lfWOnczDj[YxtKGGyb4D0c5NqeyCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>? NHzrblQzPjF5NkKxPS=>
SK-NEP-1 NFnYcGZHfW6ldHnvckBCe3OjeR?= NXm3fZVbPTBxMUCwJI5O Mmi3NlQhcA>? NHHIbHhFVVORwrC= MUHzbI94eyC2aHWgbY5lfWO2aX;uJI9nKESQQTDmdoFodWWwdHH0bY9v M3nPSlI3OTd4MkG5
G401 NIHWb2xHfW6ldHnvckBCe3OjeR?= M{LiWlUxNzFyMDDuUS=> NELhcVAzPCCq M2jnUmROW00EoB?= NFHl[Zl{cG:5czD0bIUhcW6mdXP0bY9vKG:oIFTORUBnemGpbXXueIF1cW:w M4ftTFI3OTd4MkG5
SK-NEP-1 MVzGeY5kfGmxbjDBd5NigQ>? MmrKOVAwOTByIH7N Ml3sNlQhcA>? MXXEUXNQyqB? NGjiXYFqdmS3Y3XzJINmdGxiY4njcIUh\Gm|b4Lk[ZLDqA>? M{C2T|I3OTd4MkG5
G401 Mn76SpVv[3Srb36gRZN{[Xl? MX61NE8yODBibl2= NIfjdlIzPCCq NXjWO4pLTE2VT9Mg NX3UfYhocW6mdXPld{Bk\WyuIHP5Z4xmKGSrc3;y[IVzyqB? MYGyOlE4PjJzOR?=
RPMI 8226 MkLtR4VtdCCVdYL2bZZidCCDc4PhfS=> MmrpNk81NzZibl2= NGrFZVA1QOLCiXi= M4PBRolv\HWlZYOgZUB{cWewaX\pZ4FvfCCmZXPy[YF{\SCrbjD0bIUh[2WubDDndo94fGh? MUOyOlAxODJ7Mh?=
OPM2 NIPTc49E\WyuIGP1dpZqfmGuIFHzd4F6 MnTwNk81NzZibl2= NVHwfmc4PDkkgJno MoDWbY5lfWOnczDhJJNq\26rZnnjZY51KGSnY4LlZZNmKGmwIITo[UBk\WyuIHfyc5d1cA>? MnrJNlYxODB{OUK=
U266 NX\ZTpN6S2WubDDTeZJ3cX[jbDDBd5NigQ>? NIDreVIzNzRxNjDuUS=> M1H6fVQ56oDLaB?= NIXhVFFqdmS3Y3XzJIEhe2mpbnnmbYNidnRiZHXjdoVie2ViaX6geIhmKGOnbHyg[5Jwf3Sq NXHwbnpmOjZyMECyPVI>
H929 M{THOmNmdGxiU4Xyeol3[WxiQYPzZZk> NXLpfXE{Oi92L{[gcm0> NI\MZmI1QOLCiXi= NG\0bYFqdmS3Y3XzJIEhe2mpbnnmbYNidnRiZHXjdoVie2ViaX6geIhmKGOnbHyg[5Jwf3Sq NHXQRVAzPjByMEK5Ni=>
RPMI 8226  MXfBdI9xfG:|aYOgRZN{[Xl? NGrINW416oDLbl2= NYTWO4JrOjRxNEigbC=> Mn7CbY5lfWOnczDj[YxtKGGyb4D0c5NqeyCrbjDhJJRqdWVvZHXw[Y5l\W62IH3hco5meg>? MnnXNlYxODB{OUK=
HCC827 NVr3bGxTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\nNYtzOTBibl2= NYfDdJlWPDhiaB?= MUXEUXNQ NV7r[2NT\W6qYX7j[ZMh[2m|cHzheIlvKHOnboPpeIl3cXS7wrC= NVL4O3Q1OjV7NES2NVc>
NCI-H23 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXyxNEBvVQ>? Ml;ZOFghcA>? NEm2dopFVVOR NIjWb4tmdmijbnPld{BkcXOybHH0bY4he2Wwc3n0bZZqfHoEoB?= NV3WTI45OjV7NES2NVc>
AML3 NUHFVmZXTnWwY4Tpc44hSXO|YYm= MVmwMVEh|ryP M3Hzc|I1yqCq MX\pcoR2[2W|IFTORUBnemGpbXXueIF1cW:wwrDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= NWO4RWtxOjV4MUK5OFE>
ML-1 NHHRTVJHfW6ldHnvckBCe3OjeR?= NXnWTpFQOC1zIN88US=> NE\ZbIMzPMLiaB?= NHO1fm9qdmS3Y3XzJGRPSSCocnHncYVvfGG2aX;uxsBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> M1HzOFI2PjF{OUSx
RPMI-8226vr10  MoTTSpVv[3Srb36gRZN{[Xl? M4j0S|AuOSEQvF2= Mo\TNlTDqGh? MWLpcoR2[2W|IFTORUBnemGpbXXueIF1cW:wwrDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= NIrocmEzPTZzMkm0NS=>
ML-1 NF3uU41HfW6ldHnvckBCe3OjeR?= NVXrbVZrOSEQvF2= NV:5PYhEOjUEoHi= MXPpcoNz\WG|ZYOgZ4F{eGG|ZT2zJIFkfGm4aYT5JFQu\m:uZB?= NYe2ZodTOjV4MUK5OFE>
RPMI-8226vr10  MnPrSpVv[3Srb36gRZN{[Xl? NUDLbYdWOSEQvF2= MWKyOOKhcA>? NX3CSmtvcW6lcnXhd4V{KGOjc4Dhd4UuOyCjY4Tpeol1gSB{LkWt[o9t\A>? MonONlU3OTJ7NEG=
SK-N-BE (2) NVHXem1ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHJe2M6OjUkgJno MnO4TWM2OD1zMESuNQKBkcLz4pEJO{45KG6P MVWyOVMxQDlzNh?=
SK-N-BE (2), PAN  MK MlTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVixW2dGOjUkgJno M1HNNmlEPTB;MUC0MlDjiIoEsfMAjVcvQCCwTR?= M1jTfFI2OzB6OUG2
SK-N-BE (2), MK  PAN NF\YPJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDGbZMxOjUkgJno NW\BW3duUUN3ME2zPFIvOOLCidMx5qCKPDNwMjDuUS=> NGPaU44zPTNyOEmxOi=>
SK-N-AS M3[1d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGL6U3IzPOLCiXi= NH6wS|VKSzVyPUO3MlHjiIoEsfMAjVIvPCCwTR?= Ml2xNlU{ODh7MU[=
SK-N-DZ M1\QTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jY[VI16oDLaB?= NGDHN5BKSzVyPUG3MlHjiIoEsfMAjVAvPCCwTR?= NVLDUWFGOjV|MEi5NVY>
Caki-1 NYnmT3FwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTLNVAwOjVxNUCgcm0> NFrrXXY1QCCq MkXHbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDkc5NmKGSncHXu[IVvfCCvYX7u[ZIhe3mwZYLnbZN1cWOjbHz5JJdqfGhicnn0c45ifmm{ MYSyOVI4QTF7MR?=
ACHN NIG3VFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlG4NVAwOjVxNUCgcm0> MYG0PEBp MYDpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uh\GWyZX7k[Y51KG2jbn7ldkB{gW6ncnfpd5Rq[2GubImge4l1cCC{aYTvcoF3cXJ? MYWyOVI4QTF7MR?=
769-P M2fnVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4f5SFExNzJ3L{WwJI5O MorzOFghcA>? MmTObY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDkc5NmKGSncHXu[IVvfCCvYX7u[ZIhe3mwZYLnbZN1cWOjbHz5JJdqfGhicnn0c45ifmm{ MWqyOVI4QTF7MR?=
786-O  M2\pR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\6clExNzJ3L{WwJI5O NFTod3Q1QCCq MXXpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uh\GWyZX7k[Y51KG2jbn7ldkB{gW6ncnfpd5Rq[2GubImge4l1cCC{aYTvcoF3cXJ? Ml3DNlUzPzlzOUG=
Caki-1 NFP5[plCeG:ydH;zbZMhSXO|YYm= M2LGelUxKG6P NIH1TJk1QCCq NUHFc2lbcW6mdXPld{Bk\WyuIHHwc5B1d3OrczDjc41jcW6nZDDybZRwdmG4aYK= NFnJUXQzPTJ5OUG5NS=>
ACHN Mn7WRZBweHSxc3nzJGF{e2G7 MoP2OVAhdk1? Mlu3OFghcA>? NITMbpZqdmS3Y3XzJINmdGxiYYDvdJRwe2m|IHPvcYJqdmWmIILpeI9v[X[rch?= NFjMdpAzPTJ5OUG5NS=>
769-P Mni5RZBweHSxc3nzJGF{e2G7 NHPLOFg2OCCwTR?= M2X2[FQ5KGh? MXnpcoR2[2W|IHPlcIwh[XCxcITvd4l{KGOxbXLpcoVlKHKrdH;uZZZqeg>? MWSyOVI4QTF7MR?=
786-O  NVnWVZZDSXCxcITvd4l{KEG|c3H5 NGPxdIo2OCCwTR?= M3L3bVQ5KGh? M334dolv\HWlZYOgZ4VtdCCjcH;weI9{cXNiY3;tZolv\WRicnn0c45ifmm{ M1TB[lI2Ojd7MUmx
Caki-1 Mnf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfRNlUwPTBibl2= MnzXOFghcA>? NVXJTndSTE2VTx?= NH7TRZdqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2ViZHXw[Y5l\W62IH3hco5meiC|eX7ldodqe3SrY3HscJkhf2m2aDDic5J1\XqxbXni M{nSb|I2OTd4M{W0
ACHN NXjENpJtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDENlUwPTBibl2= MmHBOFghcA>? M1zTe2ROW09? NGfRSHZqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2ViZHXw[Y5l\W62IH3hco5meiC|eX7ldodqe3SrY3HscJkhf2m2aDDic5J1\XqxbXni MWCyOVE4PjN3NB?=
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Caki-1 Mor2R49td267IF\vdo1ifGmxbjDBd5NigQ>? Mk\DOVAhdk1? NWH2O4k2Py1zNDDk NFrlboJFVVOR NH7qbFV{fXCycnXzd4VlKGOxbH;ufUBnd3KvYYTpc44he2mpbnnmbYNidnSueTDjc41jcW6nZDD3bZRpKHerdHigZo9zfGW8b33pZkDDqA>? MVqyOVE4PjN3NB?=
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Caki-1 Mnm4RZBweHSxc3nzJGF{e2G7 NVTvc2lpPTBibl2= MX[0PEBp M{HBUmROW09? M{DMbIlv\HWlZYOgZ4VtdCCjcH;weI9{cXN? NHLGW3UzPTF5NkO1OC=>
ACHN NHXwXXNCeG:ydH;zbZMhSXO|YYm= NHrveoU2OCCwTR?= MonsOFghcA>? M4nrXGROW09? MkCybY5lfWOnczDj[YxtKGGyb4D0c5Nqew>? MYOyOVE4PjN3NB?=
769-P M2iwNGFxd3C2b4Ppd{BCe3OjeR?= NF7WcZI2OCCwTR?= MknSOFghcA>? Mn;MSG1UVw>? NUO3clc2cW6mdXPld{Bk\WyuIHHwc5B1d3Orcx?= NYHpTFJKOjVzN{[zOVQ>
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BT-549 NX[0cWxGVW:{cHjvcI9ocWOjbDDDdpl{fGGuIG\pc4xmfCBqQ2[pJGF{e2G7 NF;GSpQyOMLibl2= MXKzxsBl NGLseHNFVVOR MkT5ZYx1\XK|IHPlcIwhdW:{cHjvcI9ogcLi MYCyOFgyODR7Nx?=
MCF-7  NY\OTJdFVW:{cHjvcI9ocWOjbDDDdpl{fGGuIG\pc4xmfCBqQ2[pJGF{e2G7 MX6xNOKhdk1? NYSwenRQO8LiZB?= M4HzWmROW09? M2nPWIFtfGW{czDj[YxtKG2xcoDoc4xw\3oEoB?= M{HPTlI1QDFyNEm3
MCF-7 Mnz2SpVv[3Srb36gRZN{[Xl? MXu1MVUxKG6P M2rPdFI1KGh? M1TidWROW09? NWnqSZBqemWmdXPl[EB1cGVibHX2[Ywhd2ZiZYjwdoV{e2mxbjDv[kBGWs7zLDDQVkBidmRiRn;4RVHDqA>? MXmyOFM3PjRyNx?=
CTS MkPTRZBweHSxc3nzJGF{e2G7 MWew5qCUPDBibl5CpC=> MnuyOFghcA>? M17rfolv\HWlZYOgZZBweHSxc3nzJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy MlfBNlQzPDR2Mkm=
OCI-AML3  MlfJRZBweHSxc3nzJGF{e2G7 NYnt[WhDOOLCk{SwJI5OyqB? NFziUXI1QCCq Ml2wbY5lfWOnczDhdI9xfG:|aYOgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= NXyyN4dTOjR{NES0Nlk>
U937 M2Hq[2Fxd3C2b4Ppd{BCe3OjeR?= M{HwPVDjiJN2MDDuUeKh NVr5WJhlPDhiaB?= M4Tk[Ilv\HWlZYOgZZBweHSxc3nzJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy NXHuXWRGOjR{NES0Nlk>
PC3 MYDBdI9xfG:|aYOgRZN{[Xl? NYS3N3U2OC1zMECgcm0> M1Oze|I1NzR6IHi= NHHWOnlqdmS3Y3XzJIFxd3C2b4Ppd{BqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> MojHNlQyPjN{M{C=
PC3-AR NV76SVlQSXCxcITvd4l{KEG|c3H5 M1LnT|AuOTByIH7N MXmyOE81QCCq NH;NcVdqdmS3Y3XzJIFxd3C2b4Ppd{BqdiCkb4ToJJRqdWVvIHHu[EBld3OnLXTldIVv\GWwdDDtZY5v\XJ? NF;P[4wzPDF4M{KzNC=>
PC3 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjocWpGOC1zMECgcm0> NEL3XJQzPC92ODDo MlnHbY5lfWOnczDhZ4N2dXWuYYTpc44hd2Zic4XiS|EheG:ydXzheIlwdg>? NXjz[WQxOjRzNkOyN|A>
PC3-AR M3LaSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\qWVAuOTByIH7N MoL6NlQwPDhiaB?= M4fCNYlv\HWlZYOgZ4VtdCCleXPs[UBienKnc4SgbY4hfGinIFeyUUBxcGG|ZR?= NGK3cm8zPDF4M{KzNC=>
PC3 MW\GeY5kfGmxbjDBd5NigQ>? NGHpNJgxNTFyMDDuUS=> Mom2NlQhcA>? NX;5[GNLe3WycILld5NmeyCneIDy[ZN{cW:wIH;mJIFkfGm4YYTl[EBCXE1uIFHreEBidmRiRYLrNU8zKHC{b4TlbY4> M4XkelI1OTZ|MkOw
PC3-AR MYnGeY5kfGmxbjDBd5NigQ>? M{LTVFAuOTByIH7N M37mclI1KGh? NH\MclR{fXCycnXzd4V{KGW6cILld5Nqd25ib3[gZYN1cX[jdHXkJGFVVSxiQXv0JIFv\CCHcnuxM|IheHKxdHXpci=> NFn3O5QzPDF4M{KzNC=>
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OS-RC-2 NFzjOWZCeG:ydH;zbZMhSXO|YYm= NGjsU282OCCwTR?= NInSXoE1QCCq NF7qepJFVVOR NIfKXHNqdmS3Y3XzJINmdGxiYYDvdJRwe2m| MYCyOFE1PDd|Nx?=
SK-N-AS NFKyTZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV[w5qCUQDBibl2= NGPyNHc1QCCq Mlj2TWM2OD1{Nz60JI5O MmLsNlQxQTh5OUm=
SK-N-DZ MnfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUKw5qCUQDBibl2= M1XhXlQ5KGh? M1HKWmlEPTB;MkGuPUBvVQ>? NEXYWJQzPDB7OEe5PS=>
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SK-N-AS MVjBdI9xfG:|aYOgRZN{[Xl? M3;kUFDjiJN6MDDuUS=> NEHafHM1QCCq Ml:1dI91\W62bImgbY5lfWOnZDDhdI9xfG:|aYOgbY4h[SCmb4PlMYRmeGWwZHXueEBn[XOqaX;u MorINlQxQTh5OUm=
SK-N-DZ NFLTWlBCeG:ydH;zbZMhSXO|YYm= M2K0R|DjiJN6MDDuUS=> NI\wcWQ1QCCq MYHwc5RmdnSueTDpcoR2[2WmIHHwc5B1d3OrczDpckBiKGSxc3Wt[IVx\W6mZX70JIZie2irb36= NYexR29[OjRyOUi3PVk>
SK-N-SH MX\BdI9xfG:|aYOgRZN{[Xl? M3K2dFDjiJN2MDDuUS=> M2fQbFQ5KGh? NILKfHZxd3SnboTsfUBqdmS3Y3XkJIFxd3C2b4Ppd{BqdiCjIHTvd4Uu\GWyZX7k[Y51KG[jc3jpc44> NHK5W4QzPDB7OEe5PS=>
SK-N-BE MXXBdI9xfG:|aYOgRZN{[Xl? MYKw5qCUPDBibl2= NW\UVGRFPDhiaB?= M2nYO5BwfGWwdHz5JIlv\HWlZXSgZZBweHSxc3nzJIlvKGFiZH;z[U1l\XCnbnTlcpQh\mG|aHnvci=> NGL6TY0zPDB7OEe5PS=>
SK-N-AS M3vtU2Z2dmO2aX;uJGF{e2G7 NUPxPWFlOOLCk{iwJI5O M3yycFQ5KGh? MonGbY5lfWOnczDhJIRwe2VvZHXw[Y5l\W62IHPs[YF3[WenIH;mJINie3Cjc3WgN{BidmRiUFHSVC=> NVz6eIU6OjRyOUi3PVk>
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SK-N-SH Mkj4SpVv[3Srb36gRZN{[Xl? NHX0XYcx6oDVNECgcm0> MnflOFghcA>? NHXjfJlqdmS3Y3XzJIEh\G:|ZT3k[ZBmdmSnboSgZ4xm[X[jZ3Wgc4Yh[2G|cHHz[UA{KGGwZDDQRXJR NFfyWGQzPDB7OEe5PS=>
SK-N-BE MlfXSpVv[3Srb36gRZN{[Xl? MX:w5qCUPDBibl2= M{LlclQ5KGh? NFnTc|RqdmS3Y3XzJIEh\G:|ZT3k[ZBmdmSnboSgZ4xm[X[jZ3Wgc4Yh[2G|cHHz[UA{KGGwZDDQRXJR MXOyOFA6QDd7OR?=
HCC-LM3 NH2yN21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPLbXBqOS1zMECwJI5O NWjSTINQOjRxNEivO|IhcA>? NWq1c|c3TE2VTx?= NHTlNppqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZYK= M3jGT|I1ODl|OUW2
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SMMC-7721 NYizfJI5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY[xMVExODBibl2= M1G3Z|I1NzR6L{eyJIg> NHPF[lFFVVOR M4TNTolvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= Mo\XNlQxQTN7NU[=
HCC-LM3 MmHGRZBweHSxc3nzJGF{e2G7 NGr4[Hk2OCCwTR?= MWS0PEBp M2LNR2ROW09? M{\N[olv\HWlZYOgZ4VtdCCjcH;weI9{cXNic3nncolncWOjboTsfUBqdiCjIHPhd5Bie2VvZHXw[Y5l\W62IH3hco5meiCkeTDjcIVifmGpZTDv[kBk[XOyYYPld{A{NCB6IHHu[EA6 NEfWbpYzPDB7M{m1Oi=>
HepG2 MVrBdI9xfG:|aYOgRZN{[Xl? NHriS4g2OCCwTR?= NWTse3JWPDhiaB?= MkXISG1UVw>? MWLpcoR2[2W|IHPlcIwh[XCxcITvd4l{KHOrZ37p[olk[W62bImgbY4h[SClYYPwZZNmNWSncHXu[IVvfCCvYX7u[ZIh[nliY3zlZZZi\2Vib3[gZ4F{eGG|ZYOgN{whQCCjbnSgPS=> NGXke2czPDB7M{m1Oi=>
SMMC-7721 NFPjdGNCeG:ydH;zbZMhSXO|YYm= NVvVNFdGPTBibl2= M2PGR|Q5KGh? MlzBSG1UVw>? NXvOeo1rcW6mdXPld{Bk\WyuIHHwc5B1d3OrczDzbYdvcW[rY3HueIx6KGmwIHGgZ4F{eGG|ZT3k[ZBmdmSnboSgcYFvdmW{IHL5JINt\WG4YXflJI9nKGOjc4Dhd4V{KDNuIEigZY5lKDl? MYiyOFA6Ozl3Nh?=
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HepG2 MWrGeY5kfGmxbjDBd5NigQ>? MlfGOVAwOTByIH7N MUCyOEBp MkDQSG1UVw>? NXfpPGVE\GWlcnXhd4V{KHSqZTDs[ZZmdHNib3[gdE1UXEGWMzDhcoQheC2Da4VCpC=> MoHVNlQxQTN7NU[=
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HepG2 NVXEPIdGTnWwY4Tpc44hSXO|YYm= M3;lUFUxNzFyMDDuUS=> NYLJPXRxOjRiaB?= M3;D[GROW09? MnnJ[I94dnKnZ4XsZZRmeyCEY3ytfGwh\XiycnXzd4lwdg>? MY[yOFA6Ozl3Nh?=
SMMC-7721 M3HQcmZ2dmO2aX;uJGF{e2G7 MVO1NE8yODBibl2= NFTpbJEzPCCq MWXEUXNQ NVSyd|dr\G:5boLl[5Vt[XSnczDCZ4wugExiZYjwdoV{e2mxbh?= NVHrNYpNOjRyOUO5OVY>
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PC-3  M3LDbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rrPFAuOTBizszN MUCyOE81QC95MjDo NVj5eYhkcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZo91cCC2aX3lMUBidmRiZH;z[U1l\XCnbnTlcpQhdWGwbnXy MV[yN|k6OTJzNh?=
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RWPE-1  MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2e2O|AuOjBizszN MnfaNlQwPDhxN{KgbC=> M{DYSIlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= Mo\ENlM6QTF{MU[=
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CFPAC-1  M{DJU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXqyOU82OC9zMECgcm0> NYDtSoJUPDhiaB?= MoPZSG1UVw>? MV3y[YR2[2W|IHPlcIwh\3Kxd4ToJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy NGjSZmczOzl{Mki4Oi=>
Capan-1 NEnRPXdCeG:ydH;zbZMhSXO|YYm= NVvW[Y5XOjVxNUCvNVAxKG6P MoPnOFghcA>? MoHpSG1UVw>? MV;pcoR2[2W|IHPlcIwh\3Kxd4ToJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy NIHzR|AzOzl{Mki4Oi=>
L3.6pl NWP6R|ZqSXCxcITvd4l{KEG|c3H5 Ml3BNlUwPTBxMUCwJI5O NYS2VoxOPDhiaB?= NX75RlJOTE2VTx?= MUXpcoR2[2W|IHPlcIwh\3Kxd4ToJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy MYCyN|kzOjh6Nh?=
CFPAC-1  M1T1e2Fxd3C2b4Ppd{BCe3OjeR?= NVz3PZp{OjVxNUCvNVAxKG6P MWm0PEBp MUfEUXNQ NUnsPIRzcW6mdXPld{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>? NX2yRVRTOjN7MkK4PFY>
HN22 NEPlXGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX[wMVIxKG6P M4O0bVI1NzR6IHi= NF7WOm9FVVOR M2DGeIlvcGmkaYTzJINmdGxidnnhZoltcXS7IHnuJIJwfGhidHnt[U0h[W6mIHTvd4UuKGSncHXu[IVvfCCvYX7u[ZI> NHTDRZkzOzh5N{KzOS=>
HSC4  M1jST2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXSwMVIxKG6P MYmyOE81QCCq MmjOSG1UVw>? M4Xx[IlvcGmkaYTzJINmdGxidnnhZoltcXS7IHnuJIJwfGhidHnt[U0h[W6mIHTvd4UuKGSncHXu[IVvfCCvYX7u[ZI> NY\j[YZkOjN6N{eyN|U>
HN22 NES0SpRCeG:ydH;zbZMhSXO|YYm= NFLpcWQxNTJyIH7N MV60PEBp NGDyWo5FVVOR MU\pcoR2[2W|IHPlcIwh[XCxcITvd4l{ NH;ZNIQzOzh5N{KzOS=>
HSC4  M3jMT2Fxd3C2b4Ppd{BCe3OjeR?= M4P4T|AuOjBibl2= NInUR5U1QCCq MYnEUXNQ MmOxbY5lfWOnczDj[YxtKGGyb4D0c5Nqew>? MWeyN|g4PzJ|NR?=
HN22 Mmr5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\VPIVFOC1{MDDuUS=> NWrhOGZoPDhiaB?= MUDEUXNQ MX3pcoR2[2W|IFexJJBp[XOnIHPlcIwh[3mlbHWgZZJz\XO2wrC= NWHZc2d2OjN6N{eyN|U>
HSC4  M{ezV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NECyUI4xNTJyIH7N NHe1ZWs1QCCq M124dGROW09? M3LrfIlv\HWlZYOgS|EheGijc3WgZ4VtdCCleXPs[UBienKnc4VCpC=> M4S3VVI{QDd5MkO1
HN22 NXzKWpdrTnWwY4Tpc44hSXO|YYm= NF7Hco8xNTJyIH7N MXS0PEBp NU\GN|Z6TE2VTx?= MV7zeZBxemW|c3XzJHNxOSCneIDy[ZN{cW:wwrC= MkPWNlM5Pzd{M{W=
HSC4  NXzIb5F[TnWwY4Tpc44hSXO|YYm= NH3PbXYxNTJyIH7N MVS0PEBp M1ft[WROW09? M1PO[ZN2eHC{ZYPz[ZMhW3BzIHX4dJJme3Orb39CpC=> MnfkNlM5Pzd{M{W=
Cal62 NETCW3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUWyVHN2UUN3ME2zN{DDuSB2IH7N M1TSelI{QDJ2ME[0
Hth7 MnjUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\JeGlEPTB;MUWgxtEhOiCwTR?= M3LsfFI{QDJ2ME[0
Hth83 NXG4NWQxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPITWM2OD1|NDFCtUA2KG6P M3m5TVI{QDJ2ME[0
C643 M33D[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfhWWJPUUN3ME23NUDDuSBzMDDuUS=> Mn7NNlM5OjRyNkS=
SW1736 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzFR|NKSzVyPUO1JOKyKDhibl2= M3G5flI{QDJ2ME[0
T241 M1jld2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTZ3INMxJFchdk1? MWSyN|gzPDB4NB?=
T351 NXjnOIRDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGD4Xm1KSzVyPUWwJOKyKDFyIH7N MXuyN|gzPDB4NB?=
BHP2-7 NIq1eXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTN5INMxJFYhdk1? NF3YXI8zOzh{NEC2OC=>
T238 MoezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vNSmlEPTB;MTy1NFAhyrFiMkCwJI5O NELBdJYzOzh{NEC2OC=>
HCT8 NV7tZoU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX22To96PzJiaB?= NWHYZ2pVTE2VTx?= NFG4VINKSzVyPUGyMlnjiIoEsfMAjVEvQSCwTR?= NX2zOYtjOjN{OUmzPFg>
H630 MkLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPtUVc4OiCq M2\vdWROW09? NYnXXnpWUUN3ME2xNk416oDLwsJihKk{NjFibl2= M1fCUFI{Ojl7M{i4
cH630 5-FU-res Ml[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nkVVczKGh? M2jOSWROW09? NFPRSGlKSzVyPUG1MlXjiIoEsfMAjVEvOiCwTR?= NFrjPGgzOzJ7OUO4PC=>
HCT116 MnfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\kem84OiCq MkmySG1UVw>? MlfsTWM2OD1zMD635qCKyrIkgJmyMlIhdk1? NUfZXYdFOjN{OUmzPFg>
HCT116 p53−/− NYLSSVE3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTrVG04OiCq NHjT[HVFVVOR Ml[wTWM2OD16LkdihKnDueLCiUGuO{BvVQ>? NGe3XYczOzJ7OUO4PC=>
dHCT116 p21−/− MnHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TySVczKGh? MXrEUXNQ M2PZNGlEPTB;NT655qCKyrIkgJmxMlMhdk1? M4\zO|I{Ojl7M{i4
HT29 NUfyRllyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTwdYo4OiCq NE\h[YJFVVOR MnTZTWM2OD1zNj6z5qCKyrIkgJmyMlMhdk1? MlrWNlMzQTl|OEi=
LoVo NUTmPXhmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkH0O|IhcA>? MorsSG1UVw>? MVfJR|UxRTVwMfMAjeKy6oDLMD62JI5O NYLpTnhIOjN{OUmzPFg>
RKO NV;IdZdFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGG1cHA4OiCq M4DMd2ROW09? NWXCcpRZUUN3ME23MlnjiIoEsfMAjVIvOiCwTR?= NFeyc4MzOzJ7OUO4PC=>
SW480 M1O1VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zXR|czKGh? M4rF[WROW09? NXjSeFBWUUN3ME2xO{426oDLwsJihKkxNjhibl2= NXzyVWNiOjN{OUmzPFg>
eSW620 NUfZV|N6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDvfo84OiCq MXTEUXNQ MX7JR|UxRTlwMfMAjeKy6oDLMj6xJI5O M1q1VlI{Ojl7M{i4

... Click to View More Cell Line Experimental Data

体内研究 LBH589作用于患肺癌和间皮瘤动物模型,明显降低肿瘤生长,与对照组相比平均降低62%。LBH589作用于免疫活性鼠和严重联合免疫缺陷鼠效果差不多,说明LBH589抑制肿瘤生长与免疫学无关。LBH589按20 mg/kg剂量腹腔注射,每周持续5天,导致在实验最后肿瘤生长平均下降70%。与相应的对照组肿瘤相比,LBH589作用于H526衍生的肿瘤下降53%,作用于BK-T衍生的肿瘤下降81%, 作用于RG-1衍生的肿瘤下降76%,作用于H69衍生的肿瘤下降 70%。在相同条件和剂量的情况下,LBH589 作用于NSCLC和Meso衍生的移植瘤,导致SCLC衍生的肿瘤中有两种衰退,伴随着BK-T衍生的平均肿瘤尺寸从实验开始时的296 mm3降低到实验结束时的116 mm3,RG-1衍生的平均肿瘤尺寸从实验开始时的185mm3降低到实验结束时的86 mm3[2]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:[1]
+ 展开
  • Cell lines: MOLT-4细胞和Reh(前体B细胞)
  • Concentrations: 50 nM
  • Incubation Time: 48小时
  • Method: 没有处理的细胞和LBH589处理的细胞[人类急性成淋巴细胞性白血病MOLT-4(T 细胞)和Reh(前体-B细胞)]用膜联蛋白V和碘化丙啶染色,然后加入膜联蛋白V-FITC细胞凋亡检测试剂盒I。通过流式细胞仪测定细胞凋亡和不能存活细胞的百分比。用CyAn ADP Violet细胞计数器收集至少5×104个细胞。根据所有的膜联蛋白V-阳性和膜联蛋白V/PI-阳性细胞细胞计算凋亡百分比,根据所有的膜联蛋白V-阳性和PI-阳性及膜联蛋白V/PI-阳性细胞计算细胞活力丢失百分比。
    (Only for Reference)
动物实验:[2]
+ 展开
  • Animal Models: 携带10×106个M30细胞或5×106个A549细胞的SCID鼠
  • Formulation: 溶于水的5%葡萄糖
  • Dosages: 10 mg/kg, 20 mg/kg
  • Administration: 腹腔注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 69 mg/mL (197.46 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
2% DMSO+48% PEG 300+2% Tween 80+ddH2O
5mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 349.43
化学式

C21H23N3O2

CAS号 404950-80-7
稳定性 powder
in solvent
别名 NVP-LBH589

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02032810 Active not recruiting Melanoma|Skin Cancer H. Lee Moffitt Cancer Center and Research Institute|Novartis January 7 2014 Phase 1
NCT03256045 Recruiting Recurrent Plasma Cell Myeloma|Refractory Plasma Cell Myeloma University of Washington|National Cancer Institute (NCI) May 31 2018 Phase 2
NCT01169636 Completed Hodgkin''s Lymphoma M.D. Anderson Cancer Center|Novartis January 31 2011 Phase 1|Phase 2
NCT02676323 Recruiting Acute Myeloid Leukemia|Myelodysplastic Syndrome St. Jude Children''s Research Hospital May 3 2016 Phase 1
NCT02717455 Recruiting Glioma Pediatric Brain Tumor Consortium June 28 2016 Phase 1
NCT02654990 Recruiting Multiple Myeloma Novartis Pharmaceuticals|Novartis April 27 2016 Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    How to reconstitute the compound for in vivo mice study?

  • 回答:

    We recommend the vehicle is 2 % DMSO, 2 % Tween 80, 48%PEG300, 48% water. The compound is first dissolved in DMSO, then add Tween, PEG300, water in sequence.

HDAC Signaling Pathway Map

HDAC Inhibitors with Unique Features

相关HDAC产品

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID