Panobinostat (LBH589)

For research use only. Not for use in humans.

目录号：S1030 别名： NVP-LBH589

Panobinostat (LBH589) Chemical Structure

Molecular Weight(MW): 349.43

Panobinostat (LBH589)是一种新型的，广谱HDAC抑制剂，无细胞试验中IC50为5 nM。Phase 3。

规格

价格

库存

购买数量

10mg	RMB 731.86	现货
50mg	RMB 2189.52	现货
200mg	RMB 5485.18	现货
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客户使用Selleck生产的Panobinostat (LBH589)发表文献216篇：

Cancer Cell, 2019, 36(2):179-193

PubMed: 31378681 ( click the link to review the publication )

Cancer Cell, 2019, 36(5):528-544

PubMed: 31631026 ( click the link to review the publication )

Cell, 2019, 36(2):179-193

PubMed: 28162770 ( click the link to review the publication )

Cancer Cell, 2019, 35(5):782-797

PubMed: 31085178 ( click the link to review the publication )

Nat Immunol, 2019, 20(7):835-851

PubMed: 31160797 ( click the link to review the publication )

Nat Med, 2018, 24(11):1752-1761

PubMed: 30349086 ( click the link to review the publication )

Cell, 2018, 173(6):1413-1425

PubMed: 29754815 ( click the link to review the publication )

Nat Genet, 2018, 50(10):1442-1451

PubMed: 30224647 ( click the link to review the publication )

Cancer Discov, 2017, 7(12):1450-1463

PubMed: 28963352 ( click the link to review the publication )

Cancer Cell, 2017, 31(5):635-652

PubMed: 28434841 ( click the link to review the publication )

Cancer Cell, 2016, 29(3):311-323

PubMed: 26977882 ( click the link to review the publication )

Nat Med, 2015, 10.1038/nm.3855

PubMed: 25939062 ( click the link to review the publication )

Cancer Discov, 2015, 5(3):264-73

PubMed: 25542447 ( click the link to review the publication )

Cancer Discov, 2015, 5(3):264-73

PubMed: 25542447 ( click the link to review the publication )

Cell, 2014, 159(5):1110-25

PubMed: 25416949 ( click the link to review the publication )

Nat Biotechnol, 2011, 29(3):255-65

PubMed: 21258344 ( click the link to review the publication )

Cancer Chemother Pharmacol, 2020, 10.1007/s00280-019-04021-y

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Cell Res, 2019, 29(4):286-304

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Nat Commun, 2019, 10(1):3319

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Clin Cancer Res, 2019, 10.1158/1078-0432

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Leukemia, 2019, 10.1038/s41375-019-0525-6

PubMed: 31358854 ( click the link to review the publication )

Proc Natl Acad Sci U S A, 2019, 116(26):12986-12995

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Neuro Oncol, 2019, 10.1093/neuonc/noz215

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Cancer Immunol Res, 2019, 7(2):230-243

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Haematologica, 2019, 10.3324/haematol.2018.211110

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Clin Infect Dis, 2019, 10.1093/cid/ciz108

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J Immunother Cancer, 2019, 7(1):33

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Theranostics, 2019, 9(2):540-553

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Cell Rep, 2019, 29(9):2783-2795

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Elife, 2019, 10.7554/eLife.44306

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Oncogene, 2019, 38(15):2690-2705

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J Exp Clin Cancer Res, 2019, 38(1):185

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Cancers (Basel), 2019, 11(10)

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PLoS Pathog, 2019, 15(8):e1007991

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Breast Cancer Res, 2019, 21(1):134

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Acta Pharm Sin B, 2019, 9(5):937-951

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Front Immunol, 2019, 9:3162

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Mol Cancer Ther, 2019, 18(5):900-908

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Mol Cancer Ther, 2019, 18(1):185-195

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Mol Cancer Ther, 2019, 18(8):1439-1450

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Biochim Biophys Acta Mol Basis Dis, 2019, 1865(6):1666-1676

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J Biomed Nanotechnol, 2019, 15(5):979-992

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Epigenetics, 2019, 10.1080/15592294.2019.1656156

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AIDS, 2019, 33(2):199-209

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Biomolecules, 2019, 9(5)

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Mol Pharm, 2019, 16(5):1813-1826

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J Cell Physiol, 2019, 234(10):18970-18984

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Eur J Nutr, 2019, 10.1007/s00394-019-01925-6

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J Virol, 2019, 93(24)

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Antimicrob Agents Chemother, 2019, 63(2)

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Epigenetics Chromatin, 2019, 12(1):18

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Int J Mol Sci, 2019, 20(12)

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J Biol Chem, 2019, 294(12):4437-4449

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Apoptosis, 2019, 24(1-2):184-197

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Mol Carcinog, 2019, 58(12):2230-2240

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Mol Carcinog, 2019, 58(2):234-246

PubMed: 30303565 ( click the link to review the publication )

Virus Res, 2019, 269:197631

PubMed: 31136823 ( click the link to review the publication )

Mol Genet Genomic Med, 2019, 7(5):e613

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Childs Nerv Syst, 2019, 35(5):823-831

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J Nanobiotechnology, 2019, 17(1):69

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J Virus Erad, 2019, 5(3):133-137

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Nat Commun, 2018, 9(1):4866

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Nat Commun, 2018, 9(1):764

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Clin Cancer Res, 2018, 24(16):3941-3954

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Cancer Res, 2018, 78(5):1155-1168

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Int J Cancer, 2018, 143(6):1388-1401

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Oncogene, 2018, 37(6):722-731

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Cancer Lett, 2018, 417:152-160

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Sci Signal, 2018, 11(557)

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EBioMedicine, 2018, 28:80-89

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Cell Death Dis, 2018, 9(10):944

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Mol Cancer Ther, 2018, 17(12):2767-2779

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Mol Cancer Ther, 2018, 17(8):1705-1716

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Cell Oncol (Dordr), 2018, 41(2):201-212

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J Immunol, 2018, 201(3):1086-1096

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J Virol, 2018, 92(13)

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Int J Mol Sci, 2018, 19(8)

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Sci Rep, 2018, 8(1):9472

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Biomed Pharmacother, 2018, 100:509-520

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J Cell Biochem, 2018, 119(5):4193-4204

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Retrovirology, 2018, 15(1):36

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J Ethnopharmacol, 2018, 211:267-277

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Exp Cell Res, 2018, 363(2):196-207

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PLoS One, 2018, 13(11):e0207915

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Dis Markers, 2018, 2018:3810108

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Cell Biochem Funct, 2018, 36(8):398-407

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Anticancer Drugs, 2018, 29(1):61-74

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Oncotarget, 2018, 9(92):36530-36541

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F1000Res, 2018, 7:1906

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Int J Radiat Oncol Biol Phys, 2018, 100(1):174-187

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Nat Commun, 2017, 8(1):728

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Plant Physiol, 2017, 175(4):1760-1773

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Mol Cancer Ther, 2017, 16(2):285-299

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Br J Haematol, 2017, 178(5):728-738

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Epigenetics, 2017, 12(2):105-112

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Int J Nanomedicine, 2017, 12:1385-1399

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J Biol Chem, 2017, 292(9):3683-3691

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J Pharmacol Exp Ther, 2017, 363(2):211-220

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Horm Cancer, 2017, 8(4):257-267

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Blood Adv, 2017, 1(19):1575-1583

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Genom Data, 2017, 12:14-16

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JCI Insight, 2017, 2(1):e85811

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JCI Insight, 2017, 2(6):e90196

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Oncotarget, 2017, 9(3):3908-3921

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Oncotarget, 2017, 8(55):94569-94579

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Methods Mol Biol, 2017, 1510:127-148

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Blood, 2016, 127(10):1325-35

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Nucleic Acids Res, 2016, 45(3):1159-1176

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EMBO Mol Med, 2016, 8(2):117-38

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Clin Cancer Res, 2016, 22(10):2534-44

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Int J Cancer, 2016, 139(1):194-204

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Oncogene, 2016, 35(46):6026-6037

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Mol Oncol, 2016, 10(5):735-750

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Mol Ther Methods Clin Dev, 2016, 3:16003

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J Org Chem, 2016, 81(22):11324-11334

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Mol Pharm, 2016, 13(11):3724-3735

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Sci Rep, 2016, 6:38407

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J Biol Chem, 2016, 291(16):8745-55

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Biomed Pharmacother, 2016, 84:1393-1405

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Retrovirology, 2016, 13(1):36

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J Cancer Res Clin Oncol, 2016, 142(11):2263-73

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Am J Transl Res, 2016, 8(9):3893-3902

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PLoS One, 2016, 11(2):e0148912

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Leuk Lymphoma, 2016, 57(11):2644-52

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JCI Insight, 2016, 1(5):e85061

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Ann Rheum Dis, 2015, 10.1136/annrheumdis-2014-206258

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Biomaterials, 2015, 73:110-9

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Blood Cancer J, 2015, 5:e312

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J Med Chem, 2015, 58(2):785-800

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Arch Toxicol, 2015, 89(9):1599-618

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Mol Oncol, 2015, 9(7):1447-1457

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Mol Pharm, 2015, 12(7):2469-76

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Sci Rep, 2015, 5:16445

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Am J Physiol Lung Cell Mol Physiol, 2015, 309(12):L1410-9

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J Biol Chem, 2015, 10.1074.jbc.M114.624361

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J Biol Chem, 2015, 290(49):29478-92

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J Biol Chem, 2015, 290(8):5028-40

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Cancer Biol Ther, 2015, 16(12):1784-93

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Int J Parasitol Drugs Drug Resist, 2015, 5(3):117-26

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PLoS One, 2015, 10(7):e0126566

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PLoS One, 2015, 10(8):e0134426

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Pediatr Blood Cancer, 2015, 62(1):52-9

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Pediatr Blood Cancer, 2015, 62(1):52-9

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Exp Hematol, 2015, 43(6):448-61

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Oncotarget, 2015, 6(19):17698-712

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Western University, 2015, Western University

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Oncotarget, 2015, 6(25):21507-21

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Oncotarget, 2015, 6(4):2088-100

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Cancer Lett, 2014, 356(2 Pt B):656-68

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PLoS Pathog, 2014, 10(4):e1004071

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PLoS Pathog, 2014, 10(8):e1004287

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Anal Chem, 2014, 86(10):4642-7

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Br J Cancer, 2014, 111(2):281-91

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Cell Death Dis, 2014, 5:e1134

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Br J Haematol, 2014, 167(5):639-50

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J Immunol, 2014, 193(3):1333-43

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Mol Carcinog, 2014, 53(9):722-35

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BMC Cancer, 2014, 14:17

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PLoS One, 2014, 9(11):e113341

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PLoS One, 2014, 10(8):e1004287

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Biochem Biophys Res Commun, 2014, 452(3):649-54

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Curr Pharm Desigh, 2014, 20(11):1874-80

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Head Neck, 2014, 10.1002/hed.23822

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Nat Commun, 2013, 4:2735

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Nucleic Acids Res, 2013, 41(12):6018-33

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Leukemia, 2013, 27(6):1291-300

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Cell Rep, 2013, 5(6):1679-89

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Cancer Lett, 2013, 329(1):17-26

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Breast Cancer Res, 2013, 15(4):R58

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Cell Death Dis, 2013, 4:e655

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Cell Death Dis, 2013, 4:e951

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Br J Haematol, 2013, 162(4):559-62

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Radiother Oncol, 2013, 108(3):429-33

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AIDS, 2013, 27(18):2853-62

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J Cancer Res Clin Oncol, 2013, 139(9):1507-14

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Cancer Chemother Pharmacol, 2013, 71(5):1325-34

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PLoS One, 2013, 8(8):e74253

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PLoS One, 2013, 8(11):e79106

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PLoS One, 2013, 8(9):e76662

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J Thromb Thrombolysis, 2013, 35(2):185-92

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Theriogenology, 2013, 80(6):630-5

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Protein Expr Purif, 2013, 92(1):119-127

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Genet Mol Res, 2013, 12(4):5405-13

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The University of Western Ontario, 2013, CHAE YOUNG HAN

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Obstet Gynecol Int, 2013, 2013:828165

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Blood, 2012, 119(6):1450-8

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Clin Cancer Res, 2012, 18(2):408-16

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Breast Cancer Res Tr, 2012, 131(3):777-89

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J Neurooncol, 2012, 110(3):335-48

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Acta Neuropathol, 2011, 122(5):637-50

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PLoS One, 2011, 6(2):e17138

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Sci Signal, 2010, 3(146):ra80

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Biochem Bioph Res Co, 2010, 391(4):1748-51

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产品安全说明书

HDAC抑制剂选择性比较

生物活性

产品描述

Panobinostat (LBH589)是一种新型的，广谱HDAC抑制剂，无细胞试验中IC50为5 nM。Phase 3。

靶点

HDAC (MOLT-4 cells) ^[1]	HDAC (Reh cells) ^[1]
5 nM	20 nM

体外研究

LBH589诱导MOLT-4和Reh细胞凋亡，这种作用具有时间和剂量依赖性。而且，LBH589作用于MOLT-4细胞比作用于Reh细胞更有效。LBH589明显阻止MOLT-4 和Reh细胞的生长，处理48小时，具有剂量依赖性。与对照组细胞相比，用LBH589处理的细胞，在细胞周期的G2/M期的细胞数量增多2到3倍。LBH589与组蛋白H3K9和H4K8的乙酰化作用相关，LBH589也降低c-Myc的表达水平，具有剂量依赖性。LBH589也增强p21的表达水平。最低剂量的LBH589（10 nM）处理Reh细胞，最初增强c-Myc的表达水平，之后一直降低c-Myc的表达水平。此外，LBH589促进mRNA水平的促凋亡和DNA修复基因的大量增多。在GADD45G启动子作用下，LBH589诱导乙酰化的组蛋白H3 和H4水平的增多。^[1]此外, LBH589抑制非小细胞肺癌细胞系生长，如人类H1299,L55和A549，IC50分别为5,11和30 nM；间皮瘤细胞生长，如人类OK-6和 Ok-5，IC50分别为5和7 nM；及小细胞肺癌细胞系生长，如人类RG-1和LD-T，IC50分别为4和5 nM。^[2]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
HT29	MnG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYCzeHdNOC1zMDFOwG0>	M1;LOFAuPCCm		M4PNcolvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6nch?=	M{LGSVI3PzB{N{i0
HepG2	M4rOWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGT4SpQxNTFyIN88US=>	MWqwMVQh\A>?		MmXrbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYn;0bEB1cW2nLTDhcoQh\G:\|ZT3k[ZBmdmSnboSgcYFvdmW{	NIP0T5AzPjdyMke4OC=>
HT29	MoTFSpVv[3Srb36gRZN{[Xl?	M2qwPFUxyqCwTR?=	Mn36NlQuPzJiaB?=		NGeyTXZqdmS3Y3XkJIFkfGm4YYTpc44hd2ZiY3HzdIF{\SB\|IHHmeIVzKDR6wrDoxsA>	NV\iT2ZjOjZ5MEK3PFQ>
HepG2	NFLQTHJHfW6ldHnvckBCe3OjeR?=	MmjFOVDDqG6P	MWmyOE04OiCq		NIDvO3JqdmS3Y3XkJIFkfGm4YYTpc44hd2ZiY3HzdIF{\SB\|IHHmeIVzKDJ2wrDoxsA>	MV:yOlcxOjd6NB?=
HCC827	NXL5RVdyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2D2e\|UwPy53L{GwJI5O	M3G2N\|czyqCq	NYnjVVQ4TE2VTx?=	MV;lcohidmOnczD0bIUh[W62aYDyc4xq\mW{YYTpeoUh\W[oZXP0JI9nKGW{bH;0bY5q[g>?	NUnuR3RLOjZ4N{W0PFQ>
A549	M4\TXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M17telExNzF3L{KwJI5O	Ml\OO\|LDqGh?	Ml7pSG1UVw>?	MXHlcohidmOnczD0bIUh[W62aYDyc4xq\mW{YYTpeoUh\W[oZXP0JI9nKGW{bH;0bY5q[g>?	MVKyOlY4PTR6NB?=
NCI-H460	M37IXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXXV[HhVOTBxMkCvN\|Ahdk1?	MWG3NuKhcA>?	MUTEUXNQ	MlvF[Y5p[W6lZYOgeIhmKGGwdHnwdo9tcW[ncnH0bZZmKGWoZnXjeEBw\iCncnzveIlvcWJ?	MYGyOlY4PTR6NB?=
J89GFP	M1\3SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			Mm[wSG1UV8Li	Mof1SWM2OD12OT64OUDDuSBzMj62OUBvVQ>?	NX7DcWMzOjZ3NkO1Olg>
THP89GFP	Mn;3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NHzzO\|NFVVORwrC=	MWLFR\|UxRTF7LkO0JOKyKDZwNEOgcm0>	NVvxcpFDOjZ3NkO1Olg>
SK-NEP-1	NYnaUohKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NW\UR\|lnOC5yMfMAl\|ExNjBizszN	NW\mem1HOjRiaB?=	M2\oOGROW00EoB?=	M3PG[mlEPTB;N{[uN\|Qhdk1?	NFvy[Y0zPjF5NkKxPS=>
G401	MoLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWKwMlAy6oDVMUCuNEDPxE1?	NUjxdFZyOjRiaB?=	NHLZUI5FVVORwrC=	NYTJXmZ{UUN3ME2xOFMvODJibl2=	MliwNlYyPzZ{MUm=
SK-NEP-1	NVvVOIQ3S2WubDDWbYFjcWyrdImgRZN{[Xl?	MmjrOVAhdk1?	NVqxR296OeLCk{Sg[C=>	NE\MW3FFVVORwrC=	MoK1doVlfWOnczDj[YxtKHO3co\peoFtKGmwIHGgeIlu\SCmZYDlcoRmdnRibXHucoVz	NEHn[pYzPjF5NkKxPS=>
G401	NUHvSXJzS2WubDDWbYFjcWyrdImgRZN{[Xl?	Mo\zOVAhdk1?	NHzHNWky6oDVNDDk	MXPEUXNQyqB?	MknxdoVlfWOnczDj[YxtKHO3co\peoFtKGmwIHGgeIlu\SCmZYDlcoRmdnRibXHucoVz	NInGZo4zPjF5NkKxPS=>
SK-NEP-1	M4fKXWFxd3C2b4Ppd{BCe3OjeR?=	M4rzUVUxNzFyMDDuUS=>	M3f1SVI1KGh?	NVPRcVJxTE2VT9Mg	M3fSZ4lv\HWlZYOgZ4VtdCCjcH;weI9{cXNiaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ?	NGPxWWMzPjF5NkKxPS=>
G401	M1:yXWFxd3C2b4Ppd{BCe3OjeR?=	NY\yTFd1PTBxMUCwJI5O	NWLyR5ZMOjRiaB?=	NVHRVFBETE2VT9Mg	NELWUVRqdmS3Y3XzJINmdGxiYYDvdJRwe2m\|IHnuJIEh\G:\|ZT3k[ZBmdmSnboSgcYFvdmW{	MXWyOlE4PjJzOR?=
SK-NEP-1	NH\Gd3FHfW6ldHnvckBCe3OjeR?=	MYK1NE8yODBibl2=	NXLWSolGOjRiaB?=	MVHEUXNQyqB?	M1LaSpNpd3e\|IITo[UBqdmS3Y4Tpc44hd2ZiRF7BJIZz[WevZX70ZZRqd25?	NFjvV40zPjF5NkKxPS=>
G401	MnvtSpVv[3Srb36gRZN{[Xl?	MVW1NE8yODBibl2=	NFnkT5MzPCCq	NYXwSZRPTE2VT9Mg	Ml3Pd4hwf3NidHjlJIlv\HWldHnvckBw\iCGTlGg[pJi\22nboTheIlwdg>?	M4fEdFI3OTd4MkG5
SK-NEP-1	NXzGc2Q3TnWwY4Tpc44hSXO\|YYm=	NIG0ZpE2OC9zMECgcm0>	NF\oR4gzPCCq	M1S5WGROW00EoB?=	NHLXdm9qdmS3Y3XzJINmdGxiY4njcIUh\Gm\|b4Lk[ZLDqA>?	MkDrNlYyPzZ{MUm=
G401	NXeyZYNVTnWwY4Tpc44hSXO\|YYm=	MUC1NE8yODBibl2=	MX[yOEBp	MXLEUXNQyqB?	M3jBTolv\HWlZYOgZ4VtdCCleXPs[UBlcXOxcnTlduKh	MYKyOlE4PjJzOR?=
RPMI 8226	MmXYR4VtdCCVdYL2bZZidCCDc4PhfS=>	MXKyM\|QwPiCwTR?=	NHf0Wok1QOLCiXi=		MUnpcoR2[2W\|IHGgd4lodmmoaXPhcpQh\GWlcnXhd4UhcW5idHjlJINmdGxiZ4Lve5Rp	NHjWWlIzPjByMEK5Ni=>
OPM2	NYDL[VIzS2WubDDTeZJ3cX[jbDDBd5NigQ>?	MVuyM\|QwPiCwTR?=	M3Wwe\|Q56oDLaB?=		NXuzVVZZcW6mdXPld{BiKHOrZ37p[olk[W62IHTlZ5Jm[XOnIHnuJJRp\SClZXzsJIdzd3e2aB?=	MUCyOlAxODJ7Mh?=
U266	M3HG[2NmdGxiU4Xyeol3[WxiQYPzZZk>	NHLTXXozNzRxNjDuUS=>	Mk\lOFjjiImq		MX;pcoR2[2W\|IHGgd4lodmmoaXPhcpQh\GWlcnXhd4UhcW5idHjlJINmdGxiZ4Lve5Rp	MnvPNlYxODB{OUK=
H929	MmXTR4VtdCCVdYL2bZZidCCDc4PhfS=>	NWLBO4NTOi92L{[gcm0>	NXXYU4ZyPDkkgJno		NHnXdZpqdmS3Y3XzJIEhe2mpbnnmbYNidnRiZHXjdoVie2ViaX6geIhmKGOnbHyg[5Jwf3Sq	M{HoWlI3ODByMkmy
RPMI 8226	NULIR4hQSXCxcITvd4l{KEG\|c3H5	M4HrVVTjiImwTR?=	M3f4c\|I1NzR6IHi=		NG\y[XJqdmS3Y3XzJINmdGxiYYDvdJRwe2m\|IHnuJIEhfGmvZT3k[ZBmdmSnboSgcYFvdmW{	NYjwbXNWOjZyMECyPVI>
HCC827	NGjCfmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWqxNEBvVQ>?	MnzaOFghcA>?	NYmwVmhHTE2VTx?=	NFvuXI1mdmijbnPld{BkcXOybHH0bY4he2Wwc3n0bZZqfHoEoB?=	NFXRbVkzPTl2NE[xOy=>
NCI-H23	Ml\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXexNEBvVQ>?	MYe0PEBp	NX;LbZBCTE2VTx?=	NVfKcHhY\W6qYX7j[ZMh[2m\|cHzheIlvKHOnboPpeIl3cXS7wrC=	MkW0NlU6PDR4MUe=
AML3	NYPFWmxWTnWwY4Tpc44hSXO\|YYm=	MYGwMVEh\|ryP	M4\YVFI1yqCq		M3zVc4lv\HWlZYOgSG5CKG[{YXft[Y51[XSrb39CpIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy	NW\QfHVEOjV4MUK5OFE>
ML-1	NYnVUWtpTnWwY4Tpc44hSXO\|YYm=	M4jHV\|AuOSEQvF2=	NH;kbWEzPMLiaB?=		NInDO5FqdmS3Y3XzJGRPSSCocnHncYVvfGG2aX;uxsBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=>	MmjONlU3OTJ7NEG=
RPMI-8226vr10	M1fJe2Z2dmO2aX;uJGF{e2G7	NITkc5cxNTFizszN	MWGyOOKhcA>?		M4LoN4lv\HWlZYOgSG5CKG[{YXft[Y51[XSrb39CpIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy	NXzmWY9IOjV4MUK5OFE>
ML-1	NUHNPXVXTnWwY4Tpc44hSXO\|YYm=	NV\DNGVkOSEQvF2=	MXOyOOKhcA>?		NYD6XmhNcW6lcnXhd4V{KGOjc4Dhd4UuOyCjY4Tpeol1gSB2LX\vcIQ>	Ml\2NlU3OTJ7NEG=
RPMI-8226vr10	MXLGeY5kfGmxbjDBd5NigQ>?	M3zufFEh\|ryP	NG\ZbokzPMLiaB?=		MVzpcoNz\WG\|ZYOgZ4F{eGG\|ZT2zJIFkfGm4aYT5JFIvPS2ob3zk	M2PsO\|I2PjF{OUSx
SK-N-BE (2)	NVrEW\|FsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MXWyOQKBkWh?		NWK1doV6UUN3ME2xNFQvOOLCidMx5qCKPy56IH7N	NYrXO5lxOjV\|MEi5NVY>
SK-N-BE (2), PAN MK	MnXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MU[yOQKBkWh?		MVjJR\|UxRTFyND6w5qCKyrIkgJm3Mlghdk1?	MYSyOVMxQDlzNh?=
SK-N-BE (2), MK PAN	NFv6eVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NVflXnhnOjUkgJno		MnvhTWM2OD1\|OEKuNQKBkcLz4pEJOFMvOiCwTR?=	NHPF[FQzPTNyOEmxOi=>
SK-N-AS	MlqyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NIK1Vm4zPOLCiXi=		NXr2e2JOUUN3ME2zO{4y6oDLwsJihKkzNjRibl2=	M33UR\|I2OzB6OUG2
SK-N-DZ	NVLqXWNYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MWOyOQKBkWh?		M3rQNGlEPTB;MUeuNgKBkcLz4pEJNE41KG6P	M{jhNVI2OzB6OUG2
Caki-1	NH3zb2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnfrNVAwOjVxNUCgcm0>	NGnaSpY1QCCq		MmTGbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDkc5NmKGSncHXu[IVvfCCvYX7u[ZIhe3mwZYLnbZN1cWOjbHz5JJdqfGhicnn0c45ifmm{	MWCyOVI4QTF7MR?=
ACHN	M{e2VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFzvenAyOC9{NT:1NEBvVQ>?	NXTqT25{PDhiaB?=		MkLpbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDkc5NmKGSncHXu[IVvfCCvYX7u[ZIhe3mwZYLnbZN1cWOjbHz5JJdqfGhicnn0c45ifmm{	NEO5cGwzPTJ5OUG5NS=>
769-P	Ml6xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVzkN2xmOTBxMkWvOVAhdk1?	MmjQOFghcA>?		NFzicmlqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2ViZHXw[Y5l\W62IH3hco5meiC\|eX7ldodqe3SrY3HscJkhf2m2aDDybZRwdmG4aYK=	MYCyOVI4QTF7MR?=
786-O	NFWxT2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYTYOZV5OTBxMkWvOVAhdk1?	MlPMOFghcA>?		M4nuSolvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGg[I9{\SCmZYDlcoRmdnRibXHucoVzKHO7bnXy[4l{fGmlYXzsfUB4cXSqIILpeI9v[X[rch?=	M{L5S\|I2Ojd7MUmx
Caki-1	MnW5RZBweHSxc3nzJGF{e2G7	NWPSNVh2PTBibl2=	NHLENIY1QCCq		MnjxbY5lfWOnczDj[YxtKGGyb4D0c5NqeyClb33ibY5m\CC{aYTvcoF3cXJ?	NEXFOFczPTJ5OUG5NS=>
ACHN	MkO3RZBweHSxc3nzJGF{e2G7	M3rzSFUxKG6P	MX20PEBp		MnXVbY5lfWOnczDj[YxtKGGyb4D0c5NqeyClb33ibY5m\CC{aYTvcoF3cXJ?	MnfkNlUzPzlzOUG=
769-P	MmK3RZBweHSxc3nzJGF{e2G7	NGLGdpk2OCCwTR?=	NFzKb5U1QCCq		NFXyV2dqdmS3Y3XzJINmdGxiYYDvdJRwe2m\|IHPvcYJqdmWmIILpeI9v[X[rch?=	MXWyOVI4QTF7MR?=
786-O	MYfBdI9xfG:\|aYOgRZN{[Xl?	MVm1NEBvVQ>?	NEDMWlQ1QCCq		NW\MOm9JcW6mdXPld{Bk\WyuIHHwc5B1d3OrczDjc41jcW6nZDDybZRwdmG4aYK=	NX[3bZJ4OjV{N{mxPVE>
Caki-1	MlTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{PBblI2NzVyIH7N	NFfKZ3M1QCCq	NWHUT4xDTE2VTx?=	M2Ha[olvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGg[I9{\SCmZYDlcoRmdnRibXHucoVzKHO7bnXy[4l{fGmlYXzsfUB4cXSqIHLvdpRmgm:vaXK=	M1;SS\|I2OTd4M{W0
ACHN	NH7Ye\|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmqxNlUwPTBibl2=	MXq0PEBp	NUP3ZZpSTE2VTx?=	MmDhbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDkc5NmKGSncHXu[IVvfCCvYX7u[ZIhe3mwZYLnbZN1cWOjbHz5JJdqfGhiYn;yeIV7d22rYh?=	MoTTNlUyPzZ\|NUS=
769-P	NWT2UFB3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnXCNlUwPTBibl2=	MYW0PEBp	NUjNR2VETE2VTx?=	Ml6zbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDkc5NmKGSncHXu[IVvfCCvYX7u[ZIhe3mwZYLnbZN1cWOjbHz5JJdqfGhiYn;yeIV7d22rYh?=	M1PtSVI2OTd4M{W0
Caki-1	NXvUNYJbS2:ub375JGZwem2jdHnvckBCe3OjeR?=	M4jvWVUxKG6P	MY[3MVE1KGR?	NHmxZpVFVVOR	M{S4XZN2eHC{ZYPz[YQh[2:ub375JIZwem2jdHnvckB{cWewaX\pZ4FvfGy7IHPvcYJqdmWmIIfpeIghf2m2aDDic5J1\XqxbXniJOKh	M33nUVI2OTd4M{W0
ACHN	NEHqTIJEd2yxbomgSo9zdWG2aX;uJGF{e2G7	M4C5OVUxKG6P	MUe3MVE1KGR?	NHPpbnJFVVOR	MWrzeZBxemW\|c3XkJINwdG:weTDmc5Ju[XSrb36gd4lodmmoaXPhcpRtgSClb33ibY5m\CC5aYToJJdqfGhiYn;yeIV7d22rYjFCpC=>	M2DF[\|I2OTd4M{W0
769-P	Mn3JR49td267IF\vdo1ifGmxbjDBd5NigQ>?	MXS1NEBvVQ>?	MmXqO{0yPCCm	MVjEUXNQ	NHKwVXV{fXCycnXzd4VlKGOxbH;ufUBnd3KvYYTpc44he2mpbnnmbYNidnSueTDjc41jcW6nZDD3bZRpKHerdHigZo9zfGW8b33pZkDDqA>?	MV2yOVE4PjN3NB?=
Caki-1	NY\lPGZ3SXCxcITvd4l{KEG\|c3H5	MXW1NEBvVQ>?	NIHTRpc1QCCq	NUDySZhpTE2VTx?=	MXfpcoR2[2W\|IHPlcIwh[XCxcITvd4l{	M3\iSFI2OTd4M{W0
ACHN	MmfGRZBweHSxc3nzJGF{e2G7	NEjDNnE2OCCwTR?=	MkW2OFghcA>?	NFHuUGlFVVOR	MYHpcoR2[2W\|IHPlcIwh[XCxcITvd4l{	MVGyOVE4PjN3NB?=
769-P	Mmj3RZBweHSxc3nzJGF{e2G7	MnLsOVAhdk1?	MYK0PEBp	NWWyTW5UTE2VTx?=	NYT6WG1ScW6mdXPld{Bk\WyuIHHwc5B1d3Orcx?=	M4PSNFI2OTd4M{W0
MDA-MB-231	M33W[m1wenCqb3zv[4lk[WxiQ4L5d5RidCCYaX;s[ZQhMEOYKTDBd5NigQ>?	MVOxNOKhdk1?	MojXN:Kh\A>?	M4\lN2ROW09?	MlrTZYx1\XK\|IHPlcIwhdW:{cHjvcI9ogcLi	NWK3OmxtOjR6MUC0PVc>
BT-549	NUnudno{VW:{cHjvcI9ocWOjbDDDdpl{fGGuIG\pc4xmfCBqQ2[pJGF{e2G7	MXuxNOKhdk1?	Mo\iN:Kh\A>?	MV\EUXNQ	M3:4VYFtfGW{czDj[YxtKG2xcoDoc4xw\3oEoB?=	NHzh[Y0zPDhzMES5Oy=>
MCF-7	NWHzdJU{VW:{cHjvcI9ocWOjbDDDdpl{fGGuIG\pc4xmfCBqQ2[pJGF{e2G7	MWOxNOKhdk1?	MUGzxsBl	NFP0WWZFVVOR	MnT2ZYx1\XK\|IHPlcIwhdW:{cHjvcI9ogcLi	NHL0VIwzPDhzMES5Oy=>
MCF-7	Ml3zSpVv[3Srb36gRZN{[Xl?	M1PHVFUuPTBibl2=	NFfkU\|kzPCCq	MULEUXNQ	M2rKZ5Jm\HWlZXSgeIhmKGyndnXsJI9nKGW6cILld5Nqd25ib3[gSXLPuSxiUGKgZY5lKE[xeFGxxsA>	MUSyOFM3PjRyNx?=
CTS	M{DneGFxd3C2b4Ppd{BCe3OjeR?=	NV3yUppOOOLCk{SwJI5OyqB?	MlnDOFghcA>?		MlvabY5lfWOnczDhdI9xfG:\|aYOgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK=	M3fWNFI1OjR2NEK5
OCI-AML3	NWq1NpNTSXCxcITvd4l{KEG\|c3H5	M1v4blDjiJN2MDDuUeKh	M3\Wd\|Q5KGh?		NYfyTHdXcW6mdXPld{BieG:ydH;zbZMhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI>	MUCyOFI1PDR{OR?=
U937	MnXrRZBweHSxc3nzJGF{e2G7	M4eyV\|DjiJN2MDDuUeKh	NXnpT5B7PDhiaB?=		NVXJR4xMcW6mdXPld{BieG:ydH;zbZMhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI>	MUmyOFI1PDR{OR?=
PC3	M4e4RmFxd3C2b4Ppd{BCe3OjeR?=	MkDUNE0yODBibl2=	M1fDVVI1NzR6IHi=		M2jyV4lv\HWlZYOgZZBweHSxc3nzJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy	M2D4NlI1OTZ\|MkOw
PC3-AR	M3;yfWFxd3C2b4Ppd{BCe3OjeR?=	MX2wMVExOCCwTR?=	NFrFU2czPC92ODDo		M{TsOolv\HWlZYOgZZBweHSxc3nzJIlvKGKxdHigeIlu\S1iYX7kJIRwe2VvZHXw[Y5l\W62IH3hco5meg>?	NUPFUm9DOjRzNkOyN\|A>
PC3	NHzScmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUH2OFZ3OC1zMECgcm0>	NUj5c2E5OjRxNEigbC=>		MkXrbY5lfWOnczDhZ4N2dXWuYYTpc44hd2Zic4XiS\|EheG:ydXzheIlwdg>?	NEXCfo8zPDF4M{KzNC=>
PC3-AR	NIHhZ\|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUn2S25iOC1zMECgcm0>	NI\6OYUzPC92ODDo		M{C5[Ylv\HWlZYOgZ4VtdCCleXPs[UBienKnc4SgbY4hfGinIFeyUUBxcGG\|ZR?=	MV[yOFE3OzJ\|MB?=
PC3	NISzd3JHfW6ldHnvckBCe3OjeR?=	NY\XbFVpOC1zMECgcm0>	MkDVNlQhcA>?		MoHwd5VxeHKnc4Pld{BmgHC{ZYPzbY9vKG:oIHHjeIl3[XSnZDDBWG0tKEGtdDDhcoQhTXKtMT:yJJBzd3SnaX6=	NIr3UmgzPDF4M{KzNC=>
PC3-AR	NXz2UFUyTnWwY4Tpc44hSXO\|YYm=	MUKwMVExOCCwTR?=	M1PsVlI1KGh?		NYn4U2xse3WycILld5NmeyCneIDy[ZN{cW:wIH;mJIFkfGm4YYTl[EBCXE1uIFHreEBidmRiRYLrNU8zKHC{b4TlbY4>	M3j5cFI1OTZ\|MkOw
OS-RC-2	MljxR4VtdCCYaXHibYxqfHliQYPzZZk>	NEfVc3ExNTFyMECgcm0>	M3nufFI1NzR6L{eyJIg>	M1W0SmROW09?	NH;MRpVl\WO{ZXHz[ZMh[2WubDD2bYFjcWyrdImgbY4h[m:2aDD0bY1mNSCjbnSg[I9{\S2mZYDlcoRmdnRibXHucoVz	NYXxeXp1OjRzNES3N\|c>
OS-RC-2	MkDWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mnn4OVAhdk1?	MUC0PEBp	M{fn[2ROW09?	MXTpcoR2[2W\|IFeyM20h[XK{ZYP0	Mlv5NlQyPDR5M{e=
OS-RC-2	MlfHRZBweHSxc3nzJGF{e2G7	MUG1NEBvVQ>?	NVX4VYVvPDhiaB?=	NGC3PY1FVVOR	NYfaRoVscW6mdXPld{Bk\WyuIHHwc5B1d3Orcx?=	NEfj[2UzPDF2NEezOy=>
SK-N-AS	M1v1V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUDB[mFQOOLCk{iwJI5O	NXLTV4VqPDhiaB?=		MXzJR\|UxRTJ5LkSgcm0>	Mkf5NlQxQTh5OUm=
SK-N-DZ	M{PiOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlX4NQKBmzhyIH7N	NWWyWYk3PDhiaB?=		MoDzTWM2OD1{MT65JI5O	NFzpc4ozPDB7OEe5PS=>
SK-N-SH	NX;oNZdsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NX\2PFluOOLCk{iwJI5O	NFnOWok1QCCq		NH7C[5NKSzVyPUeyMlMhdk1?	MXyyOFA6QDd7OR?=
SK-N-BE	NV:xNHc1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mo\iNQKBmzhyIH7N	M2DZSVQ5KGh?		MWnJR\|UxRTd3LkSgcm0>	Ml\xNlQxQTh5OUm=
SK-N-AS	NFvaOJFCeG:ydH;zbZMhSXO\|YYm=	NI\QRYkx6oDVOECgcm0>	Mn[4OFghcA>?		NXnwZZc4eG:2ZX70cJkhcW6mdXPl[EBieG:ydH;zbZMhcW5iYTDkc5NmNWSncHXu[IVvfCCoYYPobY9v	MXuyOFA6QDd7OR?=
SK-N-DZ	M{HoR2Fxd3C2b4Ppd{BCe3OjeR?=	MlvJNQKBmzhyIH7N	NVHmflJrPDhiaB?=		NXjITIozeG:2ZX70cJkhcW6mdXPl[EBieG:ydH;zbZMhcW5iYTDkc5NmNWSncHXu[IVvfCCoYYPobY9v	M1TSVVI1ODl6N{m5
SK-N-SH	NX[3c5JnSXCxcITvd4l{KEG\|c3H5	MUGw5qCUPDBibl2=	NFzMelg1QCCq		NHjSUmlxd3SnboTsfUBqdmS3Y3XkJIFxd3C2b4Ppd{BqdiCjIHTvd4Uu\GWyZX7k[Y51KG[jc3jpc44>	NX75XYI5OjRyOUi3PVk>
SK-N-BE	M2\pXGFxd3C2b4Ppd{BCe3OjeR?=	M3\6PVDjiJN2MDDuUS=>	Mn3JOFghcA>?		MoLxdI91\W62bImgbY5lfWOnZDDhdI9xfG:\|aYOgbY4h[SCmb4PlMYRmeGWwZHXueEBn[XOqaX;u	Mnu5NlQxQTh5OUm=
SK-N-AS	M4LYV2Z2dmO2aX;uJGF{e2G7	MUOw5qCUQDBibl2=	NGrRWmM1QCCq		NFuydJVqdmS3Y3XzJIEh\G:\|ZT3k[ZBmdmSnboSgZ4xm[X[jZ3Wgc4Yh[2G\|cHHz[UA{KGGwZDDQRXJR	MlOzNlQxQTh5OUm=
SK-N-DZ	MlPwSpVv[3Srb36gRZN{[Xl?	NGHicGEx6oDVOECgcm0>	MWO0PEBp		MXLpcoR2[2W\|IHGg[I9{\S2mZYDlcoRmdnRiY3zlZZZi\2Vib3[gZ4F{eGG\|ZTCzJIFv\CCSQWLQ	NF;mbJIzPDB7OEe5PS=>
SK-N-SH	NYLOSmZITnWwY4Tpc44hSXO\|YYm=	MYSw5qCUPDBibl2=	MoHHOFghcA>?		MVnpcoR2[2W\|IHGg[I9{\S2mZYDlcoRmdnRiY3zlZZZi\2Vib3[gZ4F{eGG\|ZTCzJIFv\CCSQWLQ	Ml\hNlQxQTh5OUm=
SK-N-BE	Mk\JSpVv[3Srb36gRZN{[Xl?	M2LmVFDjiJN2MDDuUS=>	NF3LV\|A1QCCq		M{TmZYlv\HWlZYOgZUBld3OnLXTldIVv\GWwdDDjcIVifmGpZTDv[kBk[XOyYYPlJFMh[W6mIGDBVnA>	NHj5PYszPDB7OEe5PS=>
HCC-LM3	M4WweWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkCzNU0yODByIH7N	MlLLNlQwPDhxN{KgbC=>	Mm\oSG1UVw>?	NFj2clFqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZYK=	NFrw[2UzPDB7M{m1Oi=>
HepG2	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmXXNU0yODByIH7N	NUfzTIw1OjRxNEivO\|IhcA>?	MVXEUXNQ	MX\pcohq[mm2czDj[YxtKGe{b4f0bEBqdiCkb4ToJJRqdWVvIHHu[EBld3OnLXTldIVv\GWwdDDtZY5v\XJ?	M2HNV\|I1ODl\|OUW2
SMMC-7721	NYXsfXJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHHDSGoyNTFyMECgcm0>	M2Dqc\|I1NzR6L{eyJIg>	NGrafFFFVVOR	NGDwe5pqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZYK=	NIfkXYwzPDB7M{m1Oi=>
HCC-LM3	NYLEUHlkSXCxcITvd4l{KEG\|c3H5	M4PGW\|UxKG6P	Mk\JOFghcA>?	NE\ZZWxFVVOR	M1nr[Ylv\HWlZYOgZ4VtdCCjcH;weI9{cXNic3nncolncWOjboTsfUBqdiCjIHPhd5Bie2VvZHXw[Y5l\W62IH3hco5meiCkeTDjcIVifmGpZTDv[kBk[XOyYYPld{A{NCB6IHHu[EA6	NVPKTHlXOjRyOUO5OVY>
HepG2	M2izdmFxd3C2b4Ppd{BCe3OjeR?=	NIPwZmo2OCCwTR?=	NG\4R5c1QCCq	NGH4d5JFVVOR	MoPHbY5lfWOnczDj[YxtKGGyb4D0c5NqeyC\|aXfubYZq[2GwdHz5JIlvKGFiY3HzdIF{\S2mZYDlcoRmdnRibXHucoVzKGK7IHPs[YF3[WenIH;mJINie3Cjc3XzJFMtKDhiYX7kJFk>	NUHSOGI{OjRyOUO5OVY>
SMMC-7721	M1:5UWFxd3C2b4Ppd{BCe3OjeR?=	NX3UW4pOPTBibl2=	Mn3aOFghcA>?	NUfSXVlNTE2VTx?=	NFqyfYNqdmS3Y3XzJINmdGxiYYDvdJRwe2m\|IIPp[45q\mmlYX70cJkhcW5iYTDjZZNx[XOnLXTldIVv\GWwdDDtZY5v\XJiYomgZ4xm[X[jZ3Wgc4Yh[2G\|cHHz[ZMhOyxiODDhcoQhQQ>?	NIHxdHYzPDB7M{m1Oi=>
HCC-LM3	MYHGeY5kfGmxbjDBd5NigQ>?	NF22doU2OC9zMECgcm0>	NX\WOY9pOjRiaB?=	MX;EUXNQ	NEfuTVZl\WO{ZXHz[ZMhfGinIHzleoVteyCxZjDwMXNVSVR\|IHHu[EBxNUGtdNMg	MYiyOFA6Ozl3Nh?=
HepG2	MlTQSpVv[3Srb36gRZN{[Xl?	MU[1NE8yODBibl2=	M2\ZUFI1KGh?	M1O5NmROW09?	Mn7i[IVkemWjc3XzJJRp\SCuZY\lcJMhd2ZicD3TWGFVOyCjbnSgdE1Cc3UEoB?=	NWWzSHROOjRyOUO5OVY>
SMMC-7721	NEfsZ3JHfW6ldHnvckBCe3OjeR?=	NWS4XZNFPTBxMUCwJI5O	MmTqNlQhcA>?	NFXqc\|dFVVOR	NVu4T4ZK\GWlcnXhd4V{KHSqZTDs[ZZmdHNib3[gdE1UXEGWMzDhcoQheC2Da4VCpC=>	MUKyOFA6Ozl3Nh?=
HCC-LM3	NXvvNY1FTnWwY4Tpc44hSXO\|YYm=	M3v3Z\|UxNzFyMDDuUS=>	M{m3blI1KGh?	MUDEUXNQ	Mo\D[I94dnKnZ4XsZZRmeyCEY3ytfGwh\XiycnXzd4lwdg>?	NXPHfHVpOjRyOUO5OVY>
HepG2	M1j3WWZ2dmO2aX;uJGF{e2G7	NEnoPWQ2OC9zMECgcm0>	NYK2OIp5OjRiaB?=	M2T3NGROW09?	MoLp[I94dnKnZ4XsZZRmeyCEY3ytfGwh\XiycnXzd4lwdg>?	MnPHNlQxQTN7NU[=
SMMC-7721	MYjGeY5kfGmxbjDBd5NigQ>?	NVnTV2J7PTBxMUCwJI5O	NFT0[40zPCCq	MoW3SG1UVw>?	NIK2THFld3ewcnXneYxifGW\|IFLjcE15VCCneIDy[ZN{cW:w	NXPtdpBKOjRyOUO5OVY>
FaDu	M320RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYfKPVlMOTBy4pEFcm0>	NE\WemU5NzFyL{GyJIg>		M2HpW4Rqe3CuYYnl[EBiKHOrZ37p[olk[W62IHHu[EBxem:ub37n[YQhTzJxTTDhdpJme3RiYYSgPEBidmRiMUNihKVpKHCxc4SgdoVt\WG\|ZR?=	NUKzbGVrOjRyMk[0PFI>
FaDu	NGDYOXpHfW6ldHnvckBCe3OjeR?=	MXuxNFDjiIWwTR?=	MV6yM\|QwQC9zMjDo		MnjZbY5lfWOnZDDwNlFY[WZzL1PpdFHDqGW6cILld5Nqd25?	NGnF[ZAzPDB{NkS4Ni=>
PC-3	NXv2RWZWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NILyXWQxNTFyIN88US=>	NFjNNHIzPC92OD:3NkBp		NHPCdYNqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZYK=	NGD5PXYzOzl7MUKxOi=>
LNCaP	MmHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NX\KPFloOC13IN88US=>	NFzNSYgzPC92OD:3NkBp		NEHSNoVqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZYK=	NF\sXnIzOzl7MUKxOi=>
RWPE-1	Mn\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHj6dHQxNTJyIN88US=>	MkTVNlQwPDhxN{KgbC=>		MljHbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYn;0bEB1cW2nLTDhcoQh\G:\|ZT3k[ZBmdmSnboSgcYFvdmW{	NIS5UJkzOzl7MUKxOi=>
Capan-1	NHPCOIRHfW6ldHnvckBCe3OjeR?=	MVuyOU82OC9zMECgcm0>	MYm4M\|I1NzR6IHi=	M{H5bWROW09?	NEfQR\|Jld3ewcnXneYxifGWmIGLvckBuWk6DIHHu[EBxem:2ZXnuJIV5eHKnc4Ppc44h[W6mIHTve45{fHKnYX2gd4lodmGuaX7n	NGTiV\|IzOzl{Mki4Oi=>
L3.6pl	NF3Hd3BHfW6ldHnvckBCe3OjeR?=	M1flSVI2NzVyL{GwNEBvVQ>?	NHXGVY45NzJ2L{S4JIg>	M{SzO2ROW09?	NXj3Zmlv\G:5boLl[5Vt[XSnZDDSc44hdVKQQTDhcoQheHKxdHXpckBmgHC{ZYPzbY9vKGGwZDDkc5dve3S{ZXHtJJNq\26jbHnu[y=>	NEfOfIUzOzl{Mki4Oi=>
CFPAC-1	NHS3Xm1HfW6ldHnvckBCe3OjeR?=	NX\mWlRDOjVxNUCvNVAxKG6P	NXHRNVFlQC9{ND:0PEBp	NF[wUmNFVVOR	Mon3[I94dnKnZ4XsZZRm\CCUb36gcXJPSSCjbnSgdJJwfGWrbjDlfJBz\XO\|aX;uJIFv\CCmb4fud5Rz\WGvIIPp[45idGmwZx?=	MUiyN\|kzOjh6Nh?=
Capan-1	M3Tmd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3vOb\|I2NzVyL{GwNEBvVQ>?	MXO0PEBp	M2nmbmROW09?	M1HEbZJm\HWlZYOgZ4VtdCCpcn;3eIghcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI>	MlzVNlM6OjJ6OE[=
L3.6pl	NUjlVnRVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1SzN\|I2NzVyL{GwNEBvVQ>?	MlL1OFghcA>?	M3fZUWROW09?	NX\hepBVemWmdXPld{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>?	M4j5fVI{QTJ{OEi2
CFPAC-1	MkLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYDhVnQ5OjVxNUCvNVAxKG6P	NXG2[21WPDhiaB?=	M3fkSmROW09?	NWTTbpExemWmdXPld{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>?	Mk\yNlM6OjJ6OE[=
Capan-1	MYnBdI9xfG:\|aYOgRZN{[Xl?	NFLqNXQzPS93MD:xNFAhdk1?	Mm[5OFghcA>?	MUnEUXNQ	NVjndZpFcW6mdXPld{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>?	NHvZe5ozOzl{Mki4Oi=>
L3.6pl	MXPBdI9xfG:\|aYOgRZN{[Xl?	MXSyOU82OC9zMECgcm0>	MYq0PEBp	M2T0TmROW09?	MkOybY5lfWOnczDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=>	NWH4bXhMOjN7MkK4PFY>
CFPAC-1	MYfBdI9xfG:\|aYOgRZN{[Xl?	M1\BVVI2NzVyL{GwNEBvVQ>?	NHy1VJA1QCCq	MVzEUXNQ	NFKyXWdqdmS3Y3XzJINmdGxiZ4Lve5RpKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz	MYSyN\|kzOjh6Nh?=
HN22	NXnETI9TT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3LkeFAuOjBibl2=	NXHWS21POjRxNEigbC=>	NEfXXWFFVVOR	MWHpcohq[mm2czDj[YxtKH[rYXLpcIl1gSCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMUBl\XCnbnTlcpQhdWGwbnXy	MVmyN\|g4PzJ\|NR?=
HSC4	MlPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYewMVIxKG6P	MYOyOE81QCCq	Ml6wSG1UVw>?	NWTCd5MxcW6qaXLpeJMh[2WubDD2bYFjcWyrdImgbY4h[m:2aDD0bY1mNSCjbnSg[I9{\S1iZHXw[Y5l\W62IH3hco5meg>?	M3G2dVI{QDd5MkO1
HN22	NYTjOoJkSXCxcITvd4l{KEG\|c3H5	MnrQNE0zOCCwTR?=	NHy3U241QCCq	MWjEUXNQ	MWXpcoR2[2W\|IHPlcIwh[XCxcITvd4l{	NUm1WXpkOjN6N{eyN\|U>
HSC4	MXnBdI9xfG:\|aYOgRZN{[Xl?	NYPHcYFqOC1{MDDuUS=>	NVv6cmdLPDhiaB?=	MVXEUXNQ	MlrIbY5lfWOnczDj[YxtKGGyb4D0c5Nqew>?	M{HXc\|I{QDd5MkO1
HN22	NHnFVlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnrFNE0zOCCwTR?=	NUXnWpA3PDhiaB?=	MYTEUXNQ	NXvl[5U{cW6mdXPld{BIOSCyaHHz[UBk\WyuIHP5Z4xmKGG{cnXzeOKh	NHzKSGwzOzh5N{KzOS=>
HSC4	Mnq1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MonVNE0zOCCwTR?=	M{jjNVQ5KGh?	MoPaSG1UVw>?	NUnj[mQ3cW6mdXPld{BIOSCyaHHz[UBk\WyuIHP5Z4xmKGG{cnXzeOKh	MljHNlM5Pzd{M{W=
HN22	MWDGeY5kfGmxbjDBd5NigQ>?	NYLCR25wOC1{MDDuUS=>	MVq0PEBp	NWLMSJI5TE2VTx?=	NULrUo9xe3WycILld5NmeyCVcEGg[ZhxemW\|c3nvcuKh	NF7TfGEzOzh5N{KzOS=>
HSC4	NXH3NmZlTnWwY4Tpc44hSXO\|YYm=	NYrqO5BvOC1{MDDuUS=>	NXvCTnd7PDhiaB?=	MWTEUXNQ	NVjMdmx1e3WycILld5NmeyCVcEGg[ZhxemW\|c3nvcuKh	M4TOOVI{QDd5MkO1
Cal62	MojXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYnJR\|UxRTN\|INMxJFQhdk1?	M2rtUFI{QDJ2ME[0
Hth7	NUnMR5MxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mn;aTWM2OD1zNTFCtUAzKG6P	Ml64NlM5OjRyNkS=
Hth83	MmDJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGfqd5VKSzVyPUO0JOKyKDVibl2=	MmnWNlM5OjRyNkS=
C643	M13veGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MnXHTWM2OD15MTFCtUAyOCCwTR?=	MoTvNlM5OjRyNkS=
SW1736	NIThb4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MkTOTWM2OD1\|NTFCtUA5KG6P	NITScJUzOzh{NEC2OC=>
T241	M{DmUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MoTKTWM2OD14NTFCtUA4KG6P	M1m3TlI{QDJ2ME[0
T351	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MWTJR\|UxRTVyINMxJFExKG6P	NEHod4IzOzh{NEC2OC=>
BHP2-7	NEnCVGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXzNU4pHUUN3ME2zO{DDuSB4IH7N	MVuyN\|gzPDB4NB?=
T238	NH\CbpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MknlTWM2OD1zLEWwNEDDuSB{MECgcm0>	NVrDb2prOjN6MkSwOlQ>
HCT8	M4XsdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NY[w[VBxPzJiaB?=	NFjGUVJFVVOR	NHHv[YFKSzVyPUGyMlnjiIoEsfMAjVEvQSCwTR?=	M4ntOVI{Ojl7M{i4
H630	M3z5emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MYe3NkBp	NYe5TpduTE2VTx?=	M4Xzd2lEPTB;MUKuOQKBkcLz4pEJN{4yKG6P	MUWyN\|I6QTN6OB?=
cH630 5-FU-res	NHTaT41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NX\aN4V3PzJiaB?=	NWjycJhsTE2VTx?=	NETkc5RKSzVyPUG1MlXjiIoEsfMAjVEvOiCwTR?=	MkHYNlMzQTl\|OEi=
HCT116	M4jqOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NWnIPHI2PzJiaB?=	NVGyNVNqTE2VTx?=	MUnJR\|UxRTFyLkhihKnDueLCiUKuNkBvVQ>?	MlnuNlMzQTl\|OEi=
HCT116 p53−/−	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NITWWlc4OiCq	MV7EUXNQ	NYHsbGhnUUN3ME24MlbjiIoEsfMAjVEvPyCwTR?=	NXq4enR5OjN{OUmzPFg>
dHCT116 p21−/−	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		M2[wUlczKGh?	NImzdoxFVVOR	MlLOTWM2OD13LkpihKnDueLCiUGuN{BvVQ>?	MXGyN\|I6QTN6OB?=
HT29	Ml3oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NXPERlBGPzJiaB?=	MknkSG1UVw>?	M{L1NGlEPTB;MU[uN-KBkcLz4pEJNk4{KG6P	MVGyN\|I6QTN6OB?=
LoVo	Mo\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		M2XjcVczKGh?	NY[5WmxSTE2VTx?=	M4XHZWlEPTB;NT6x5qCKyrIkgJmwMlYhdk1?	NGHqOFEzOzJ7OUO4PC=>
RKO	NFvseI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		M{DqNlczKGh?	MXjEUXNQ	NGnROFhKSzVyPUeuPgKBkcLz4pEJNk4zKG6P	NEnhcJUzOzJ7OUO4PC=>
SW480	MkHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NXO1VIpTPzJiaB?=	M2DIdGROW09?	NHXP[pVKSzVyPUG3MlXjiIoEsfMAjVAvQCCwTR?=	M2LUfFI{Ojl7M{i4
eSW620	NEnybpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		M13MPVczKGh?	MW\EUXNQ	NIHKV5ZKSzVyPUmuNgKBkcLz4pEJNk4yKG6P	M2n4N\|I{Ojl7M{i4

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	DNMT1 / EZH2; PubMed: 19279403 Cancer Biol Ther Western blot of DNMT1 and EZH2 in K562 and LAMA84 following 24 hours treatment with the indicated doses of panobinostat (PS). The levels of β-actin served as the loading control. caspase-8 / cleaved caspase-8 / Sp1; PubMed: 27738323 Oncotarget The indicated MM cell lines were cultured for 24 hours in the absence or presence of panobinostat at the indicated concentrations. Then, the protein levels of caspase-8, cleaved caspase 8 and Sp1 were analyzed by Western blotting. c-Myc / IRF4; PubMed: 27738323 Oncotarget RPMI8226 cells were cultured for 24 hours in the absence or presence of panobinostat at the indicated concentrations. Then, the protein levels of cMyc and IRF4 were analyzed by Western blotting. Ac-H3 / cleaved caspase-3 / CCND1 / ID1 / ID2 / ID3 / ID4 / Synaptophysin / NeuroD1; PubMed: 28915627 Oncotarget Immunoblotting of whole cell lysates prepared from MB cells treated with panobinostat. The representative western blot result shows panobinostat clearly regulated acetyl-Histone H3 (Ac-H3), cleaved caspase-3, CCND1, IDs, synaptophysin and NeuroD1. RAD51 / BRCA1 / CHK1 / RPL13a; PubMed: 24244429 PLoS One CTS, OCI-AML3 or U937 AML cells were treated with variable concentrations of panobinostat for 48 h. Whole cell lysates were subjected to Western blotting to measure protein levels for BRCA1, CHK1, and RAD51 in the cells. H3K9AC / H3K18AC / H3K56AC / H3 / H4K8AC / H4K16AC / H4 / p21 / p27 / cleaved PARP; PubMed: 31071955 Int J Mol Sci Immunoblot analyses of histone acetylation (H3K9AC, H3K18AC, H3K56AC, H4K8AC and H4K16AC), cell cycle arrest (p27 and p27) and apoptotic-related protein (C-Caspase 3 and C-PARP) expression following various panobinostat treatments for 6 h and 24 h on K562 cells. H3, H4 and GAPDH immunoblots served as internal controls.	19279403 27738323 28915627 24244429 31071955
Immunofluorescence	Synaptophysin / NACM; PubMed: 28915627 Oncotarget Panobinostat treated cells are positive for (B) synaptophysin (red) and (C) NCAM (red). Scale bars, 50 μm. α-tubulin / Acetyl-α-tubulin; PubMed: 29983882 Oncotarget CLBL-1 cells were treated with 10 nM of panobinostat for 24 h and then microtubules were visualized by immunofluorescence labeling using antibodies against tubulin and acetylated tubulin (ac-tubulin) using the appropriate excitation and emission filters as described in the material and methods section. Representative microphotographs with tubulin and ac-tubulin labeling (green) and DAPI stained-nuclei (blue) at 100× magnification are shown. Scale bar, 5 μm. BiP; PubMed: 23544167 Transl Oncol Immunofluorescence analysis of BiP after 24 and 48 hours of treatment in HepG2 (upper panel) and Hep3B (lower panel) cells with 0.1 µM panobinostat and 10 nM thapsigargin, showing an increase and a different protein distribution in panobinostat-treated cells, comparable to 10 nM thapsigargin effect, used as a positive control. Immunofluorescence analysis has been performed under identical settings. Nuclei were stained with Hoechst 33342. Magnification is x630, and scale bar represents 10 µm. ATF4; PubMed: 23544167 Transl Oncol HepG2 (left panel) and Hep3B (right panel) cells were treated for 24 and 48 hours with 0.1 µM panobinostat and the immunofluorescence results show an increase of ATF4 and its nuclear localization in both cell lines. Immunofluorescence analysis has been performed under identical settings. Nuclei were stained with Hoechst 33342. Magnification is x630, and scale bar represents 10 µm. IRE1α / S724-IRE1α; PubMed: 23544167 Transl Oncol Analysis of IRE1α/XBP1 involvement. Immunofluorescence results of IRE1α and its phosphorylated form in HepG2 (A) and Hep3B (B) cell lines after 24 and 48 hours of treatment with 0.1 µM panobinostat. The results indicate that panobinostat induces an increase of both the total and the phosphorylated form of IRE1α and a spotted distribution of this protein (enlargement showed for phospho-IRE1α, B). Immunofluorescence analysis has been performed under identical settings. Nuclei were stained with Hoechst 33342. Magnification is x630, and scale bar represents 10 µm.	28915627 29983882 23544167
Growth inhibition assay	Cell viability; PubMed: 27738323 Oncotarget The indicated MM cell lines were cultured in triplicate in the absence or presence of panobinostat at the indicated concentrations. After culturing for 48 hours, cell viability was measured by a WST-8 cell proliferation assay. Results were expressed as the mean +/− SD.	27738323

体内研究

LBH589作用于患肺癌和间皮瘤动物模型,明显降低肿瘤生长，与对照组相比平均降低62%。LBH589作用于免疫活性鼠和严重联合免疫缺陷鼠效果差不多，说明LBH589抑制肿瘤生长与免疫学无关。LBH589按20 mg/kg剂量腹腔注射，每周持续5天，导致在实验最后肿瘤生长平均下降70%。与相应的对照组肿瘤相比，LBH589作用于H526衍生的肿瘤下降53%，作用于BK-T衍生的肿瘤下降81%, 作用于RG-1衍生的肿瘤下降76%，作用于H69衍生的肿瘤下降 70%。在相同条件和剂量的情况下，LBH589 作用于NSCLC和Meso衍生的移植瘤，导致SCLC衍生的肿瘤中有两种衰退，伴随着BK-T衍生的平均肿瘤尺寸从实验开始时的296 mm³降低到实验结束时的116 mm³，RG-1衍生的平均肿瘤尺寸从实验开始时的185mm³降低到实验结束时的86 mm³。^[2]

细胞实验：^[1]	- 合并 Cell lines: MOLT-4细胞和Reh(前体B细胞) Concentrations: 50 nM Incubation Time: 48小时 Method: 没有处理的细胞和LBH589处理的细胞[人类急性成淋巴细胞性白血病MOLT-4(T 细胞)和Reh(前体-B细胞)]用膜联蛋白V和碘化丙啶染色，然后加入膜联蛋白V-FITC细胞凋亡检测试剂盒I。通过流式细胞仪测定细胞凋亡和不能存活细胞的百分比。用CyAn ADP Violet细胞计数器收集至少5×10⁴个细胞。根据所有的膜联蛋白V-阳性和膜联蛋白V/PI-阳性细胞细胞计算凋亡百分比，根据所有的膜联蛋白V-阳性和PI-阳性及膜联蛋白V/PI-阳性细胞计算细胞活力丢失百分比。 (Only for Reference)
动物实验：^[2]	- 合并 Animal Models: 携带10×10⁶个M30细胞或5×10⁶个A549细胞的SCID鼠 Formulation: 溶于水的5%葡萄糖 Dosages: 10 mg/kg, 20 mg/kg Administration: 腹腔注射 (Only for Reference)

参考文献

- 合并

溶解度 (25°C)

体外	DMSO	69 mg/mL (197.46 mM)
	Water	Insoluble
	Ethanol	Insoluble
体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： 2% DMSO+48% PEG 300+2% Tween 80+ddH2O	5mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download Panobinostat (LBH589) SDF

分子量	349.43
化学式	C₂₁H₂₃N₃O₂
CAS号	404950-80-7
储存条件	3年 -20°C粉状
储存条件	2年 -80°C 溶于溶剂
别名	NVP-LBH589

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

临床试验信息 (data from https://clinicaltrials.gov, updated on 2019-10-14)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT03632317	Withdrawn	Drug: Panobinostat\|Drug: Everolimus	Glioma\|Diffuse Intrinsic Pontine Glioma	University of Michigan Rogel Cancer Center	October 2019	Phase 2
NCT03982134	Withdrawn	Drug: PDR001\|Drug: Panobinostat	Melanoma\|Non Small Cell Lung Cancer	Muhammad Furqan\|Novartis Pharmaceuticals\|University of Iowa	September 2019	Phase 1
NCT03515915	Recruiting	--	Patients With Recurrent or Refractory Multiple Myeloma	University Hospital Montpellier\|Poitiers University Hospital	April 23 2018	--

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

常见问题及建议解决方法

问题 1：
How to reconstitute the compound for in vivo mice study?
回答：
We recommend the vehicle is 2 % DMSO, 2 % Tween 80, 48%PEG300, 48% water. The compound is first dissolved in DMSO, then add Tween, PEG300, water in sequence.

HDAC Signaling Pathway Map

HDAC Inhibitors with Unique Features

选择性强的HDAC抑制剂

RGFP966 : HDAC3-selective, IC50=80 nM.
选择性强的HDAC抑制剂

Rocilinostat (ACY-1215) : HDAC5-selective, IC50=5 nM.
活性最高的HDAC抑制剂

Quisinostat (JNJ-26481585) : HDAC1, IC50=0.11 nM; HDAC2, IC50=0.33 nM.
FDA批准的HDAC抑制剂

Vorinostat (SAHA, MK0683) : Approved by FDA for cutaneous T cell lymphoma.
最新的HDAC抑制剂

RG2833 (RGFP109) ^New : Brain-penetrant HDAC inhibitor with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3, respectively.

研究领域

产品类型

Panobinostat (LBH589)

客户使用Selleck生产的Panobinostat (LBH589)发表文献216篇：

产品安全说明书

HDAC抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download Panobinostat (LBH589) SDF

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

临床试验信息 (data from https://clinicaltrials.gov, updated on 2019-10-14)

技术支持

常见问题及建议解决方法

HDAC Signaling Pathway Map

HDAC Inhibitors with Unique Features

相关HDAC产品