Romidepsin (FK228, Depsipeptide)

For research use only. Not for use in humans.

目录号:S3020 别名: FR 901228, NSC 630176 中文名称:罗米地辛

Romidepsin (FK228, Depsipeptide) Chemical Structure

CAS No. 128517-07-7

Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176)是一种有效的HDAC1HDAC2抑制剂,无细胞试验中IC50分别为36 nM和47 nM。Romidepsin (FK228/depsipeptide) 在神经母细胞瘤肿瘤细胞中可控制生长并诱导凋亡。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 13415.22 现货
RMB 1285.83 现货
RMB 6445.57 现货
RMB 12858.74 现货
有超大折扣

今日订购,明日送达,全国免运费!

全国免费电话:400-668-6834   |   Email:info@selleck.cn

客户使用Selleck生产的Romidepsin (FK228, Depsipeptide)发表文献148篇:

产品安全说明书

HDAC抑制剂选择性比较

生物活性

产品描述 Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176)是一种有效的HDAC1HDAC2抑制剂,无细胞试验中IC50分别为36 nM和47 nM。Romidepsin (FK228/depsipeptide) 在神经母细胞瘤肿瘤细胞中可控制生长并诱导凋亡。
特性 Romidepsin对I型HDAC的抑制作用明显强于对II型HDAC的抑制。
靶点
HDAC1 [1]
(Cell-free assay)
HDAC2 [1]
(Cell-free assay)
36 nM 47 nM
体外研究

Romidepsin抑制NSCLC细胞系生长,IC50范围从1.3 ng/mL到4.9 ng/mL。 Romidepsin可以降低Erlotinib对NSCLC细胞系的IC50值, 增加NSCLC细胞系对Erlotinib的敏感性[1]。Romidepsin处理72小时可以抑制6/6 人 NB 肿瘤细胞系的生长,而 NIH3T3细胞系并不受影响。 Romidepsin对于单拷贝或N-myc 多拷贝的NB细胞系以及含有正常或突变的p53 和含有Alk突变体的细胞系都有选择性的细胞毒性,这种毒性具有剂量依赖的特性。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
SU-DHL4 NULCcYJiS2WubDDWbYFjcWyrdImgRZN{[Xl? MVSyMlUuOTVibl2= M{nn[FczKGh? MX\pcoR2[2W|IHP5eI91d3irY3n0fUBqdiCjIHPvcoNmdnS{YYTpc44u\GWyZX7k[Y51KG2jbn7lduKh NYHKWWxpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3PVA6ODdpPkK1O|kxQTB5PD;hQi=>
U2932  NFfIbZRE\WyuIG\pZYJqdGm2eTDBd5NigQ>? M1\p[VIvPS1zNTDuUS=> MnHDO|IhcA>? NV\xeGE1cW6mdXPld{BkgXSxdH;4bYNqfHliaX6gZUBkd26lZX70doF1cW:wLXTldIVv\GWwdDDtZY5v\XMEoB?= MliwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5OUC5NFcoRjJ3N{mwPVA4RC:jPh?=
OCI-LY7 MWrD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NWHMSoRZOi53LUG1JI5O M2q1fVczKGh? NGTsZWVqdmS3Y3XzJIN6fG:2b4jpZ4l1gSCrbjDhJINwdmOnboTyZZRqd25vZHXw[Y5l\W62IH3hco5mesLi NH3PZnI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe5NFkxPyd-MkW3PVA6ODd:L3G+
Farage Mn7XR4VtdCCYaXHibYxqfHliQYPzZZk> NHLBZWgzNjVvMUWgcm0> M4L2ZlczKGh? M{HxT4lv\HWlZYOgZ5l1d3SxeHnjbZR6KGmwIHGgZ49v[2WwdILheIlwdi2mZYDlcoRmdnRibXHucoVzyqB? M{D2OVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{mwPVA4Lz5{NUe5NFkxPzxxYU6=
LY7/EBV MU\D[YxtKF[rYXLpcIl1gSCDc4PhfS=> NF3FU2ozNjVvMUWgcm0> MmGyO|IhcA>? NG\RXVhqdmS3Y3XzJIN6fG:2b4jpZ4l1gSCrbjDhJINwdmOnboTyZZRqd25vZHXw[Y5l\W62IH3hco5mesLi MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd7MEmwO{c,OjV5OUC5NFc9N2F-
U2932/EBV NWr2[WhoS2WubDDWbYFjcWyrdImgRZN{[Xl? M1r6SlIvPS1zNTDuUS=> M1\WVVczKGh? NFvObGJqdmS3Y3XzJIN6fG:2b4jpZ4l1gSCrbjDhJINwdmOnboTyZZRqd25vZHXw[Y5l\W62IH3hco5mesLi MonEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5OUC5NFcoRjJ3N{mwPVA4RC:jPh?=
HCT116 NYTCfVRpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PhcVUuPTByMDDuUS=> NGDOWlgzPCCq NI[ycmZFVVOR NFfXNWdqdmS3Y3XzJINmdGxiZHXheIghcW5iYTDjc45k\W62cnH0bY9vNWSncHXu[IVvfCCvYX7u[ZI> NFW5[2g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUS5NlUyPSd-MkW0PVI2OTV:L3G+
ACH-2 NVX2TJRFTnWwY4Tpc44hSXO|YYm= M33lWFEuQSCwTR?= M2[ze|I1KGh? NH7wPG9qdmS3Y3XzJGhKXi1zIFXuekBmgHC{ZYPzbY9v NHfubWo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUG0PVQ3Pyd-MkWxOFk1Pjd:L3G+
MCF-10A MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzYTWM2OD1yLkG3xtExNjBzIH7N MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3NEi1Okc,OjR7NUS4OVY9N2F-
MCF-7 NVmxO493T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DaO2lEPTB;MT6xNOKyOC5{MDDuUS=> NV\Sb4tiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5OVQ5PTZpPkK0PVU1QDV4PD;hQi=>
SK-BR-3 NEjTbXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTFwMEFCtVAvOzVibl2= NF;odVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1OFg2Pid-MkS5OVQ5PTZ:L3G+
MDA-MB-231 MnfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTBwNklCtVAvOTRibl2= MlfiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
PC3 NFTHdVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPvXW9KSzVyPUGuOlXDuTBwM{Wgcm0> M4r6NVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUW0PFU3Lz5{NEm1OFg2PjxxYU6=
HCT116 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3OzSmlEPTB;MT6wNOKyOC5yMDDuUS=> M2jId|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUW0PFU3Lz5{NEm1OFg2PjxxYU6=
HCT116-p21-/- MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFToVYpKSzVyPUGuNlbDuTBwM{egcm0> NFXSPZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1OFg2Pid-MkS5OVQ5PTZ:L3G+
S1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPsTWM2OD15Lk[3xtExNjJ7IH7N Mn\6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
SW620 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvjTWM2OD1yLkmzxtExNjJ7IH7N MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3NEi1Okc,OjR7NUS4OVY9N2F-
LOX-IMVI MkDmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXhc3BKSzVyPUCuPFfDuTBwMEOgcm0> MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3NEi1Okc,OjR7NUS4OVY9N2F-
UACC-62 NGDqOmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLSemoxUUN3ME2wMlU3yrFyLkG2JI5O NGm2dnE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1OFg2Pid-MkS5OVQ5PTZ:L3G+
MDA-MB-435 M33Kemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1y5WGlEPTB;MD65NOKyOC5yNjDuUS=> M2rWbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUW0PFU3Lz5{NEm1OFg2PjxxYU6=
SF-295 NGS4eoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV[2dJNTUUN3ME2wMlg5yrFyLkG1JI5O Ml7iQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
A549 NXu0T21ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfqb3FKSzVyPUGuNlbDuTBwMkSgcm0> Mo[2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
H460 NH\PPWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLmNJFKSzVyPUKuOVjDuTBwOECgcm0> M{DjbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUW0PFU3Lz5{NEm1OFg2PjxxYU6=
EKVX MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moq2TWM2OD1zLkOzxtExNjN2IH7N M1fESVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUW0PFU3Lz5{NEm1OFg2PjxxYU6=
H146 M3i5TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\mPWlEPTB;MD6yNuKyOC5yNzDuUS=> Mm\EQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
H526 M{DIdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrBTWM2OD1yLkG1xtExNjB|IH7N NVvJ[YJ3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5OVQ5PTZpPkK0PVU1QDV4PD;hQi=>
HuT-78 NGTw[lVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHvTWM2OD1zLkezxtExNjR2IH7N MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3NEi1Okc,OjR7NUS4OVY9N2F-
HA NXjKcY9PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlu1NE43OjVvMUDuUS=> NGPEPZI1QCCq NHPtcIJqdmS3Y3XzJIEhe2mpbnnmbYNidnSueTDzeJJwdmencjDpcohq[mm2aX;uJI9nKGOnbHygdJJwdGmoZYLheIlwdiClbz30doVifGWmIIfpeIgh[m:{dHX6c41q[g>? NYT0XVJ6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3O|E2OTBpPkK0O|cyPTFyPD;hQi=>
MS-275 NFvWU|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmG3NE43OjVvMUDuUS=> NXPodI9[PDhiaB?= M{T6NYlv\HWlZYOgZUB{cWewaX\pZ4FvfGy7IIP0do9v\2W{IHnubIljcXSrb36gc4Yh[2WubDDwdo9tcW[ncnH0bY9vKGOxLYTy[YF1\WRid3n0bEBjd3K2ZYrvcYlj NXKzVHJnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3O|E2OTBpPkK0O|cyPTFyPD;hQi=>
CD4 T NUThXYhST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVe0PEBp Mli3SWM2OD12LkZCtVEvOCCwTR?= M{PWW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{KyOFU1Lz5{NEeyNlQ2PDxxYU6=
CD4 T NV3Wdo5NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPiNoRnPDhiaB?= NWPMbGJZS0N3ME2xNFfDuTF{NjDuUS=> MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd{MkS1OEc,OjR5MkK0OVQ9N2F-
CD4+ T NV\qPHZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkGzSWM2OD1|IH7N MmfrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR2OUWxNFUoRjJ2NEm1NVA2RC:jPh?=
A549 M1\tO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYWxNQKBmzFyMNMgcm0> Ml;iNlQwOzZxNEigbC=> MorrbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYn;0bEBkd26lZX70doF1cW:wLTDhcoQhfGmvZT3k[ZBmdmSnboSgcYFvdmW{ NGftdpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NES4OVc6QSd-MkS0PFU4QTl:L3G+
JJN3 M33YUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlP4NlQwPDhiaB?= MkW2SWM2ODxz4pEJcm08KDR64pEJbC=> NHLjdmU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NECzNFE2OCd-MkSwN|AyPTB:L3G+
OPM-2 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPQNlQwPDhiaB?= MXjFR|Uxez1z4pEJcm08KDR64pEJbC=> M{HaZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEOwNVUxLz5{NECzNFE2ODxxYU6=
RPMI-8226 NXHTO|dnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHoNlQwPDhiaB?= MVHFR|Uxez1zLklihKlvVTtiNElihKlp NHvBOpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NECzNFE2OCd-MkSwN|AyPTB:L3G+
U266 NWP0bHduT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUiyOE81QCCq NGHMdXhGSzVyc{2xNQKBkW6POzC0PQKBkWh? NF3vPYU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NECzNFE2OCd-MkSwN|AyPTB:L3G+
CA46 NHyzPJhCeG:ydH;zbZMhSXO|YYm= NETUWHc3KGh? NXLYRWtycW6mdXPld{BjdHWwdDDhdI9xfG:|aYO= MonOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7Nk[xOlQoRjJ|OU[2NVY1RC:jPh?=
DG75 NFS4R45CeG:ydH;zbZMhSXO|YYm= Mom0OkBp M{TMSYlv\HWlZYOgco8h[XCxcITvd4l{ NG\yOGY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2OlE3PCd-MkO5OlYyPjR:L3G+
Ramos MYrBdI9xfG:|aYOgRZN{[Xl? MkDnOkBp MnLybY5lfWOnczDlfJRmdnOrdnWgZZBweHSxc3nz NYnwepM{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5OlYyPjRpPkKzPVY3OTZ2PD;hQi=>
ST486 MWTBdI9xfG:|aYOgRZN{[Xl? M1zI[VYhcA>? MXTpcoR2[2W|IHX4eIVve2m4ZTDhdI9xfG:|aYO= NFnCNHg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2OlE3PCd-MkO5OlYyPjR:L3G+
HuT78 MnO2RZBweHSxc3nzJGF{e2G7 MWCxM|ExNzFyMDDuUS=> M4q2d|Q5KGh? MkLlbY5lfWOnczDhdI9xfG:|aYOgZZQhOSCwTR?= M{n4VFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NUOyO|MzLz5{M{WzNlc{OjxxYU6=
DpVp35 NFrQc3hCeG:ydH;zbZMhSXO|YYm= NGrs[5oyNzFyL{GwNEBvVQ>? MV60PEBp NVnMe5F5cW6mdXPld{BjdHWwdDDhdI9xfG:|aYO= M2TVWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NUOyO|MzLz5{M{WzNlc{OjxxYU6=
DpVp50 MmPDRZBweHSxc3nzJGF{e2G7 MVexM|ExNzFyMDDuUS=> NYLFcGEyPDhiaB?= Mom5bY5lfWOnczDicJVvfCCjcH;weI9{cXN? MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzV|MkezNkc,OjN3M{K3N|I9N2F-
DpP75  MnXERZBweHSxc3nzJGF{e2G7 Mkn0NU8yOC9zMECgcm0> M4m4W|Q5KGh? M3nJRYlv\HWlZYOgZox2dnRiYYDvdJRwe2m| MmP5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3M{K3N|IoRjJ|NUOyO|MzRC:jPh?=
SKOV-3 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mly5NgKBmzJybl2= MWO3NkBp MoLLSG1UVw>? M3fre5Jm\HWlZYOgZ4VtdCC4aXHibYxqfHliYXzvcoUh[W6mIHPvcYJqdmWmIIfpeIgh[2m|cHzheIlv NFXkOHo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{CxNFM1QCd-MkOwNVA{PDh:L3G+
Brca1 WT M3vyc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVKxS2VLOeLCk{Kwcm0> NEGxVYQ4OiCq MnLQSG1UVw>? MVfy[YR2[2W|IHPlcIwhfmmjYnnsbZR6KGGub37lJIFv\CClb33ibY5m\CC5aYToJINqe3CuYYTpci=> M4K5[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MEGwN|Q5Lz5{M{CxNFM1QDxxYU6=
Brca1 Null M3ntcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Oxc|HjiJN{MH7N M3XSTVczKGh? NGH1fZlFVVOR MnfGdoVlfWOnczDj[YxtKH[rYXLpcIl1gSCjbH;u[UBidmRiY3;tZolv\WRid3n0bEBkcXOybHH0bY4> NUj3PYJqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwNVA{PDhpPkKzNFExOzR6PD;hQi=>
OVCAR-8  MmDiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jOXFHjiJN{MH7N MVG3NkBp NH\NdmpFVVOR MoexdoVlfWOnczDj[YxtKH[rYXLpcIl1gSCjbH;u[UBidmRiY3;tZolv\WRid3n0bEBkcXOybHH0bY4> NFSxW5g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{CxNFM1QCd-MkOwNVA{PDh:L3G+
NCI/ADR-RES NWj0Vpg5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnHNgKBmzJybl2= MWC3NkBp M1nuTGROW09? MXjy[YR2[2W|IHPlcIwhfmmjYnnsbZR6KGGub37lJIFv\CClb33ibY5m\CC5aYToJINqe3CuYYTpci=> MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzBzMEO0PEc,OjNyMUCzOFg9N2F-
HCT116 NFHRPIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvWcmU2KG6PLUWwJO69VQ>? MXOyOEBp M37WUGROW09? NIqwSItqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJINwdmOnboTyZZRqd25vZHXw[Y5l\W62IH3hco5meg>? MkLFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ7MkS5OVgoRjJ{OUK0PVU5RC:jPh?=
RKO NVXEenE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYm1JI5ONTVyIN88US=> MnW5NlQhcA>? NYTBU|VPTE2VTx?= NHjhPYNqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJINwdmOnboTyZZRqd25vZHXw[Y5l\W62IH3hco5meg>? M1riUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OUK0PVU5Lz5{MkmyOFk2QDxxYU6=
CO115 NV;ueG01T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjNdVB3PSCwTT21NEDPxE1? MmDINlQhcA>? MljwSG1UVw>? M3TxSIlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGgZ49v[2WwdILheIlwdi2mZYDlcoRmdnRibXHucoVz M4[zfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OUK0PVU5Lz5{MkmyOFk2QDxxYU6=
HFS NYT6V3lDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILvTo42KG6P M1fSOVI1NzR6L{eyJIg> MnzUbY5pcWKrdIOgZ4VtdCCpcn;3eIghfGmvZT3k[ZBmdmSnboTsfS=> NH32bJg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkGwOlI5Oid-MkKxNFYzQDJ:L3G+
LNCaP NEHObIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPmR|E2KG6P MoThNlQwPDhxN{KgbC=> NHTufVhqdmirYnn0d{Bk\WyuIHfyc5d1cCC2aX3lMYRmeGWwZHXueIx6 M{LxeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MUC2NlgzLz5{MkGwOlI5OjxxYU6=
A549 NFTBe4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zJ[|Uhdk1? M{DCU|I1NzR6L{eyJIg> MWfpcohq[mm2czDj[YxtKGe{b4f0bEB1cW2nLXTldIVv\GWwdHz5 NICzS3A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkGwOlI5Oid-MkKxNFYzQDJ:L3G+
697  NGHWdlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfNTWM2OOLCiU5ihKkzNjYEoH7N M3[1UFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNUO4NlE3Lz5{MUWzPFIyPjxxYU6=
697-R MmXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFyzXWFKSzVy4pEJQgKBkThwNtMgcm3DqA>? NEO1U3o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUWzPFIyPid-MkG1N|gzOTZ:L3G+
HUT78 NW\6PG1jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHyTWM2OD1zIH7N NV3PWmZkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGxPVg2PDVpPkKxNVk5PTR3PD;hQi=>
THJ-16T NHTKcWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjETpQyKG6P MWiyOEBp M1jCbYlvcGmkaYTzJINmdGxiZ4Lve5Rp NVPKUpJFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4NVA2PjhpPkKwPFExPTZ6PD;hQi=>
HCT116 NFzNPWxHfW6ldHnvckBCe3OjeR?= MYqyNEBvVQ>? M4fKO|ghcA>? NEHIclZud2S3bHH0[ZMhfHKjboPjdolxfCCuZY\lcJMh\m:{IHj1coRz\WS|IH;mJIdmdmW|IHnuJIVqfGincjDkbZJm[3Srb36= NYrsZZlnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC3N|k1PTRpPkKwO|M6PDV2PD;hQi=>
B104  NELyd2dHfW6ldHnvckBCe3OjeR?= M1K4RVIhdk1? MlW2NlQwPDhxN{KgbC=> NXrXUYNvcW6lcnXhd4V{KHSqZTDzeZJn[WOnIHX4dJJme3Orb36gc4YhS0R{MNMg MnjFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB4OE[1NFUoRjJyNki2OVA2RC:jPh?=
HL-60  M1P6cmN6fG:2b4jpZ4l1gSCDc4PhfS=> NG\0R4UyNTVyMDDuUS=> MV6yOEBp MnrObY5lfWOnczDjfZRwfG:6aXPpeJkhcW5iYTDjc45k\W62cnH0bY9vNWSncHXu[IVvfCCvYX7u[ZLDqA>? Mn3wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB4MkSxOlMoRjJyNkK0NVY{RC:jPh?=
HP100 M1uwe2N6fG:2b4jpZ4l1gSCDc4PhfS=> M1jMdlEuPTByIH7N MUeyOEBp NEL6O5dqdmS3Y3XzJIN6fG:2b4jpZ4l1gSCrbjDhJINwdmOnboTyZZRqd25vZHXw[Y5l\W62IH3hco5mesLi MnjOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB4MkSxOlMoRjJyNkK0NVY{RC:jPh?=
HL-60  M1[wSGZ2dmO2aX;uJGF{e2G7 MkXzNVAhdk1? NFzCT4g1NzZxMU[gbC=> MV;pcoR2[2W|IITo[UBo\W6ncnH0bY9vKG:oIHj5[JJw\2WwIIDldo95cWSnIH\yc40hPGh? MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODZ{NEG2N{c,OjB4MkSxOlM9N2F-
HP100 MUnGeY5kfGmxbjDBd5NigQ>? Ml3FNVAhdk1? Mn:3OE83NzF4IHi= Ml60bY5lfWOnczD0bIUh\2WwZYLheIlwdiCxZjDofYRzd2enbjDw[ZJwgGmmZTDmdo9uKDSq NGHmOI89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{ME[yOFE3Oyd-MkC2NlQyPjN:L3G+
HL-60  M37GXGZ2dmO2aX;uJGF{e2G7 NV3LWXNUOTBvNUCwJI5O M{XKfVQhcA>? MVrk[YNz\WG|ZYOgeIhmKGirc4TvcoUh\GWjY3X0fYxie2ViKFjERWMqKGGldHn2bZR6yqB? M{[xSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNkK0NVY{Lz5{ME[yOFE3OzxxYU6=
HP100 MkfDSpVv[3Srb36gRZN{[Xl? MYKxNE02ODBibl2= M1HZVlQhcA>? NGHpNppl\WO{ZXHz[ZMhfGinIHjpd5RwdmViZHXhZ4V1gWyjc3WgLGhFSUNrIHHjeIl3cXS7wrC= M1TDeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNkK0NVY{Lz5{ME[yOFE3OzxxYU6=
11z MULLbY5ie2ViQYPzZZk> MVyzMVExOCCwTR?= NImxToJz\WS3Y3XzJGhFSUNiZX76fY1ifGmlIHHjeIl3cXS7IDjJR|UxyqB;IE[uOUDDuSByLk[gco1wdC:OKR?= MnnZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB4MEWxOFQoRjJyNkC1NVQ1RC:jPh?=
SKOV-3 NVzWRnl1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUm0M|gwOTZibl2= M1TTOVQ5KGh? NFnVeYtqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJINwdmOnboTyZZRqd25vZHXw[Y5l\W62IH3hco5meg>? NITSU289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MESwOFU3PCd-MkC0NFQ2PjR:L3G+
OVCAR-3 MoCyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LpRVQwQC9zNjDuUS=> Mor1OFghcA>? M2K2c4lvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGgZ49v[2WwdILheIlwdi2mZYDlcoRmdnRibXHucoVz NYPwXpFzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC0NFQ2PjRpPkKwOFA1PTZ2PD;hQi=>
HBL-2 M4TpZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfRe5UzNTFyIH7N NE\qOYYzPCCq MX;JR|UxRTRwMzDuUS=> MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODB4OEC4NEc,OjByNkiwPFA9N2F-
Jeko-1 MnjxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGW1PYUzNTVyIH7N NFzpeI4zPCCq M1HDTWlEPTB;MUGgcm0> MmrPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjByNkiwPFAoRjJyME[4NFgxRC:jPh?=
Granta-519 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrMOU01OCCwTR?= NHXxZpgzPCCq MVTJR|UxRTV6LkWgcm0> M2LhcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyME[4NFgxLz5{MEC2PFA5ODxxYU6=
L1236 NHXER5lEgXSxdH;4bYNqfHliQYPzZZk> M332eVEhdk1vMUCwJO69VQ>? NX;R[Y9pPDhiaB?= Moe4SWM2OD1yLkC3JO69VQ>? MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ|M{S3NEc,OTl{M{O0O|A9N2F-
L428 MkLVR5l1d3SxeHnjbZR6KEG|c3H5 NEXERZUyKG6PLUGwNEDPxE1? NVrO[I9CPDhiaB?= M1O5d2VEPTB;MD60N{DPxE1? NGHoSJk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUKzN|Q4OCd-MUmyN|M1PzB:L3G+
KM-H2 NVjCT2h1S3m2b4TvfIlkcXS7IFHzd4F6 NUHJRm5uOSCwTT2xNFAh|ryP MVq0PEBp M3fQd2VEPTB;MD61PEDPxE1? NGf4Rnk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUKzN|Q4OCd-MUmyN|M1PzB:L3G+
L540Cy MmrSR5l1d3SxeHnjbZR6KEG|c3H5 NX3Jc2dKOSCwTT2xNFAh|ryP MXi0PEBp M3HuZmVEPTB;MD6xOkDPxE1? MkP4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{M{O0O|AoRjF7MkOzOFcxRC:jPh?=
G401 M176eGZ2dmO2aX;uJGF{e2G7 NUXRO3F4OTBibl2= NGLjXWkzPC92OD:3NkBp NYq0T2hRTE2VTx?= NF\NeYdqdmO{ZXHz[ZMhS0SNTkHDJIV5eHKnc4Ppc44> NUHObo5KRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyNlE2QDZpPkG5NlIyPTh4PD;hQi=>
STM91-01 NInXd2FHfW6ldHnvckBCe3OjeR?= M1S1VFExKG6P MVKyOE81QC95MjDo NYTSVohxTE2VTx?= Mof3bY5kemWjc3XzJGNFU05zQzDlfJBz\XO|aX;u MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ{MUW4Okc,OTl{MkG1PFY9N2F-
SJSC  NWXo[5N[TnWwY4Tpc44hSXO|YYm= MXixNEBvVQ>? Mnz5NlQwPDhxN{KgbC=> Mn;nSG1UVw>? NY[xfpRJcW6lcnXhd4V{KEOGS16xR{BmgHC{ZYPzbY9v M4fvSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkKxOVg3Lz5zOUKyNVU5PjxxYU6=
BT16  MmfzSpVv[3Srb36gRZN{[Xl? NELlbHkyOCCwTR?= NFmyR|gzPC92OD:3NkBp NYTO[WVPTE2VTx?= MnnVbY5kemWjc3XzJGNFU05zQzDlfJBz\XO|aX;u MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ{MUW4Okc,OTl{MkG1PFY9N2F-
NCI-H1299 NUfpTVNFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzRbZZkUUN3ME20MlbDuTBwMjDu[{9udA>? M3LnelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MUe5PFkxLz5zOUG3PVg6ODxxYU6=
NCI-2882 NVPuUmMzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV23THV[UUN3ME2xMlbDuTBwMESgcocwdWx? NH:zbmU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUG3PVg6OCd-MUmxO|k5QTB:L3G+
HCC95 M4Dn[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjFVGw5UUN3ME2yMlXDuTBwMEWgcocwdWx? NUn5N2Z2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmxO|k5QTBpPkG5NVc6QDlyPD;hQi=>
NCI-H23 NVrmW5ROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3O1eWlEPTB;Mj65xtExNjJibnevcYw> Ml7NQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlzN{m4PVAoRjF7MUe5PFkxRC:jPh?=
NCI-H157 NIj6SJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;KfmlEPTB;MT62xtExNjB{IH7nM41t NYjkO|JFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmxO|k5QTBpPkG5NVc6QDlyPD;hQi=>
NCI-H460 M1vXSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2X1NWlEPTB;Mj6xxtExNjB5IH7nM41t NGP6cXY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUG3PVg6OCd-MUmxO|k5QTB:L3G+
NCI-H1975 M3zre2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rIemlEPTB;MT6zxtExNjB2IH7nM41t M1rzXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MUe5PFkxLz5zOUG3PVg6ODxxYU6=
NCI-H820 M1\PXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTZOJZRUUN3ME2yMlTDuTBwMTDu[{9udA>? NUHabog6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmxO|k5QTBpPkG5NVc6QDlyPD;hQi=>
NCI-H1650 M4jme2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnzTWM2OD12LkpCtVAvOyCwZz;tcC=> M1rOO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MUe5PFkxLz5zOUG3PVg6ODxxYU6=
DTC1 NVW1bHFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFiwRotKSzVyPUCuOVEhdk1? M1fi[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NU[2NlQ3Lz5zOEW2OlI1PjxxYU6=
KAO NFvEbJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWq0fI1[UUN3ME2wMlkyKG6P NYWwTItTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1OlYzPDZpPkG4OVY3OjR4PD;hQi=>
SU-CCS-1 MlPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPYbG1KSzVyPUCuPFkhdk1? M{DKbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NU[2NlQ3Lz5zOEW2OlI1PjxxYU6=
SYO-1 NGLCeXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zPWGlEPTB;MD62O{BvVQ>? M2nCd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NU[2NlQ3Lz5zOEW2OlI1PjxxYU6=
FUJI NUjHU|VoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTFwM{Ggcm0> MlXqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh3Nk[yOFYoRjF6NU[2NlQ3RC:jPh?=
SKNMC MkTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGP6T2dKSzVyPUGuNVchdk1? MnvLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh3Nk[yOFYoRjF6NU[2NlQ3RC:jPh?=
402-91 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnkTWM2OD1zLkK2JI5O MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDV4NkK0Okc,OTh3Nk[yOFY9N2F-
1765-92 NXvCbJlnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1iyUGlEPTB;MT63O{BvVQ>? M1y3dlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NU[2NlQ3Lz5zOEW2OlI1PjxxYU6=
JN-DSRCT-1 M3vrT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLmU45bUUN3ME2xMlI2KG6P MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDV4NkK0Okc,OTh3Nk[yOFY9N2F-
NMS-2PC NGHKdHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2Lxc2lEPTB;MD64NUBvVQ>? M1X5blxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NU[2NlQ3Lz5zOEW2OlI1PjxxYU6=
HL60 NGf4[3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TaWWlEPTB;MT64OkBvVQ>? MmPhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh3Nk[yOFYoRjF6NU[2NlQ3RC:jPh?=
A549 M1nHW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fmVWlEPTB;Mz6yOEBvVQ>? NH3xOXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEW2OlI1Pid-MUi1OlYzPDZ:L3G+
SW480 M1nuNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPqTWM2OD1{Lk[5JI5O MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDV4NkK0Okc,OTh3Nk[yOFY9N2F-
MCF7 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTNwNUWgcm0> NIfmdYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEW2OlI1Pid-MUi1OlYzPDZ:L3G+
PC-3 NVGxT5NTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEL1PW9KSzVyPUKuOVEhdk1? Mnv5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh3Nk[yOFYoRjF6NU[2NlQ3RC:jPh?=
MMRU Ml;LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHzTWM2OD1{LkW3JI5O M4PNXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NU[2NlQ3Lz5zOEW2OlI1PjxxYU6=
Hs68 NWXkVWo2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTWTWM2OD1-MUCgcm0> M3vPRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NU[2NlQ3Lz5zOEW2OlI1PjxxYU6=
hMSC-001F M1LkVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXmyc|gxUUN3ME2+NVAhdk1? NXnqfWRQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1OlYzPDZpPkG4OVY3OjR4PD;hQi=>
mammalian cells M1rMe2Z2dmO2aX;uJIF{e2G7 MmTTTY5pcWKrdHnvckBw\iCKaYP0c45mKGSnYXPleJlt[XOnIESgbY4hdWGvbXHsbYFvKGOnbHzzMEBKSzVyIE2gNE42OSEQvF2u NFK0VWc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNEW4OFk{Oid-MUS1PFQ6OzJ:L3G+
mammalian cells NHvI[JRHfW6ldHnvckBie3OjeR?= Mn\lTY5pcWKrdHnvckBw\iCKaYP0c45mKGSnYXPleJlt[XOnIEGgbY5lfWOnZDDhZ4V1gWyjdHXkJIhqe3SxbnWgbY4hdWGvbXHsbYFvKGOnbHzzMkwhTUN3MDC9JFM3KM7:TT6= NI\EWHc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNEW4OFk{Oid-MUS1PFQ6OzJ:L3G+
MCF7 MlzSS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmjSS5Jwf3SqIHnubIljcXSrb36gc4YhVUOINzDj[YxteyxiSVO1NEA:KDBwMECwO|Uh|ryPLh?= MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzl3OEO0Nkc,OTd7NUizOFI9N2F-
A498 NXjHdmpSS3m2b4TvfIlkcXS7IHHzd4F6 M3S4SVYh\GG7cx?= M1vOWWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE1QThiY3XscJMh[W[2ZYKgOkBl[Xm|IHL5JG1VXCCjc4PhfUwhXEeLIE2gNE4xOjhizszNMi=> NVPmU4xwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlcyPDZpPkKxPVY4OTR4PD;hQi=>
COLO205 NEP2b|hEgXSxdH;4bYNqfHliYYPzZZk> Ml\hOkBl[Xm| MWXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDU2xQOjB3IHPlcIx{KGGodHXyJFYh\GG7czDifUBOXFRiYYPzZZktKFSJSTC9JFAvODNzIN88UU4> NHe0XGc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm2O|E1Pid-MkG5OlcyPDZ:L3G+
U251 MVLDfZRwfG:6aXPpeJkh[XO|YYm= M17MeVYh\GG7cx?= NUH2NFM3S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXTJ3MTDj[YxteyCjZoTldkA3KGSjeYOgZpkhVVSWIHHzd4F6NCCWR1mgQUAxNjB|MTFOwG0v NGjSbYM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm2O|E1Pid-MkG5OlcyPDZ:L3G+
RXF393 NYX0epk3S3m2b4TvfIlkcXS7IHHzd4F6 NH7oWnc3KGSjeYO= M2rWWWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHJZTjN7MzDj[YxteyCjZoTldkA3KGSjeYOgZpkhVVSWIHHzd4F6NCCWR1mgQUAxNjB4MjFOwG0v NInvXnA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm2O|E1Pid-MkG5OlcyPDZ:L3G+
MDA-MB-468 MUnDfZRwfG:6aXPpeJkh[XO|YYm= M2jp[lYh\GG7cx?= M1;0U2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj20Olgh[2WubIOgZYZ1\XJiNjDkZZl{KGK7IF3UWEBie3OjeTygWGdKKD1iMD6wPUDPxE1w Ml;6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkexOFYoRjJzOU[3NVQ3RC:jPh?=
COLO205 MlfzR5l1d3SxeHnjbZR6KGG|c3H5 NV3hUXg{PiCmYYnz MYPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDU2xQOjB3IHPlcIx{KGGodHXyJFYh\GG7czDifUBOXFRiYYPzZZktKEyFNUCgQUAxNjB7MjFOwG0v MoLtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkexOFYoRjJzOU[3NVQ3RC:jPh?=
UACC257 MUXDfZRwfG:6aXPpeJkh[XO|YYm= NF:3RnM3KGSjeYO= MXrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDVRWNEOjV5IHPlcIx{KGGodHXyJFYh\GG7czDifUBOXFRiYYPzZZktKFSJSTC9JFAvODl3IN88UU4> NGPFXms9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm2O|E1Pid-MkG5OlcyPDZ:L3G+
U251 MmfCR5l1d3SxeHnjbZR6KGG|c3H5 MmfWOkBl[Xm| NHnzWmlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBWOjVzIHPlcIx{KGGodHXyJFYh\GG7czDifUBOXFRiYYPzZZktKEyFNUCgQUAxNjF|IN88UU4> NHLqe|E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm2O|E1Pid-MkG5OlcyPDZ:L3G+
A498 M3rVNWN6fG:2b4jpZ4l1gSCjc4PhfS=> Mn;3OkBl[Xm| NF\0RXlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPDl6IHPlcIx{KGGodHXyJFYh\GG7czDifUBOXFRiYYPzZZktKEyFNUCgQUAxNjJizszNMi=> NUHldGN6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlcyPDZpPkKxPVY4OTR4PD;hQi=>
NCI-H322M M1LDemN6fG:2b4jpZ4l1gSCjc4PhfS=> NWX0O2tnPiCmYYnz Mm\pR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUmNKNUh|MkLNJINmdGy|IHHmeIVzKDZiZHH5d{BjgSCPVGSgZZN{[XluIGTHTUA:KDBwMkOg{txONg>? NHHDV489[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm2O|E1Pid-MkG5OlcyPDZ:L3G+
SF295 M3nBXWN6fG:2b4jpZ4l1gSCjc4PhfS=> NUDKb4NNPiCmYYnz Mlz1R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2YzQTViY3XscJMh[W[2ZYKgOkBl[Xm|IHL5JG1VXCCjc4PhfUwhXEeLIE2gNE4zPSEQvF2u M164fVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
RXF393 MlvyR5l1d3SxeHnjbZR6KGG|c3H5 MUG2JIRigXN? MUTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDSXGY{QTNiY3XscJMh[W[2ZYKgOkBl[Xm|IHL5JG1VXCCjc4PhfUwhVEN3MDC9JFAvOyEQvF2u Mom3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkexOFYoRjJzOU[3NVQ3RC:jPh?=
NCI60 M2H4Z2N6fG:2b4jpZ4l1gSCjc4PhfS=> Mo\6OkBl[Xm| NUDkZ3JyS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVkOLNkCgZ4VtdHNiYX\0[ZIhPiCmYYnzJIJ6KE2WVDDhd5NigSxiVFfJJF0hOC5|MzFOwG0v MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl4N{G0Okc,OjF7NkexOFY9N2F-
SN12C MYHDfZRwfG:6aXPpeJkh[XO|YYm= MYG2JIRigXN? NFS1TGZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUVjF{QzDj[YxteyCjZoTldkA3KGSjeYOgZpkhVVSWIHHzd4F6NCCWR1mgQUAxNjN2IN88UU4> M4XzT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
MDA-MB-231 NFr6b21EgXSxdH;4bYNqfHliYYPzZZk> MkPZOkBl[Xm| MWTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDZiZHH5d{BjgSCPVGSgZZN{[XluIGTHTUA:KDBwM{Wg{txONg>? MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl4N{G0Okc,OjF7NkexOFY9N2F-
ACHN M3vhTGN6fG:2b4jpZ4l1gSCjc4PhfS=> M1HveVYh\GG7cx?= NEfOOmtEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCS0iQIHPlcIx{KGGodHXyJFYh\GG7czDifUBOXFRiYYPzZZktKFSJSTC9JFAvPzNizszNMi=> NI\qOGQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm2O|E1Pid-MkG5OlcyPDZ:L3G+
SN12C NIPOS2ZEgXSxdH;4bYNqfHliYYPzZZk> NYfwVHVYPiCmYYnz MX\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTUlEzSyClZXzsd{Bi\nSncjC2JIRigXNiYomgUXRVKGG|c3H5MEBNSzVyIE2gNU42KM7:TT6= NYHNOIN6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlcyPDZpPkKxPVY4OTR4PD;hQi=>
UO31 MlnHR5l1d3SxeHnjbZR6KGG|c3H5 NUDM[FN{PiCmYYnz MoLwR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWW8{OSClZXzsd{Bi\nSncjC2JIRigXNiYomgUXRVKGG|c3H5MEBVT0liPTCxMlU2KM7:TT6= MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl4N{G0Okc,OjF7NkexOFY9N2F-
Caki1 M{[yTWN6fG:2b4jpZ4l1gSCjc4PhfS=> M2rDWVYh\GG7cx?= MYjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDZYtqOSClZXzsd{Bi\nSncjC2JIRigXNiYomgUXRVKGG|c3H5MEBVT0liPTCxMlg6KM7:TT6= M1TiS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
NCI60 NXLY[49PS3m2b4TvfIlkcXS7IHHzd4F6 NF3mVHE3KGSjeYO= Mn6zR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUmNKPjBiY3XscJMh[W[2ZYKgOkBl[Xm|IHL5JG1VXCCjc4PhfUwhVEN3MDC9JFMvPSEQvF2u M1nVblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
MDA-MB-231 NUjBT|R5S3m2b4TvfIlkcXS7IHHzd4F6 M4TydFYh\GG7cx?= M{XCbmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZYZ1\XJiNjDkZZl{KGK7IF3UWEBie3OjeTygUGM2OCB;IESuNFgh|ryPLh?= NUL4THdSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlcyPDZpPkKxPVY4OTR4PD;hQi=>
MDA-MB-468 NF7NR4NEgXSxdH;4bYNqfHliYYPzZZk> MljGOkBl[Xm| NGPnT|hEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtOFY5KGOnbHzzJIFnfGW{IE[g[IF6eyCkeTDNWHQh[XO|YYmsJGxEPTBiPTC0MlE1KM7:TT6= M33tNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
ACHN MorUR5l1d3SxeHnjbZR6KGG|c3H5 Ml60OkBl[Xm| NFXXTotEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCS0iQIHPlcIx{KGGodHXyJFYh\GG7czDifUBOXFRiYYPzZZktKEyFNUCgQUA2NjN5IN88UU4> NFHjb3c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm2O|E1Pid-MkG5OlcyPDZ:L3G+
UACC257 MlnOR5l1d3SxeHnjbZR6KGG|c3H5 Mm\qOkBl[Xm| MnrKR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWWFESzJ3NzDj[YxteyCjZoTldkA3KGSjeYOgZpkhVVSWIHHzd4F6NCCOQ{WwJF0hPS52NjFOwG0v MmXlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkexOFYoRjJzOU[3NVQ3RC:jPh?=
NCI-H322M NIDPbYFEgXSxdH;4bYNqfHliYYPzZZk> MWe2JIRigXN? M4nRSWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5EUS2KM{KyUUBk\WyuczDh[pRmeiB4IHThfZMh[nliTWTUJIF{e2G7LDDMR|UxKD1iOT6wNkDPxE1w NXXKV2FXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlcyPDZpPkKxPVY4OTR4PD;hQi=>
SF295 M1y4eGN6fG:2b4jpZ4l1gSCjc4PhfS=> M3L4dlYh\GG7cx?= MXTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTSlI6PSClZXzsd{Bi\nSncjC2JIRigXNiYomgUXRVKGG|c3H5MEBNSzVyIE2gNVAvOiEQvF2u NVPLWWZ7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlcyPDZpPkKxPVY4OTR4PD;hQi=>
Caki1 M1fCZmN6fG:2b4jpZ4l1gSCjc4PhfS=> NWjHdnczPiCmYYnz NICzO4xEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBE[WurMTDj[YxteyCjZoTldkA3KGSjeYOgZpkhVVSWIHHzd4F6NCCOQ{WwJF0hOjBwOTFOwG0v NWjtW5hTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlcyPDZpPkKxPVY4OTR4PD;hQi=>
NCI-H23 MUXBcpRqfHWvb4KgZZN{[Xl? NVz6PXE4OS54IITvJFIvPCCvZz;r[y=> M2PqUJVxKHSxIEWg[IF6ew>? NXGwSXFKSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUmNKNUh{MzDj[YxteyCrbYDsZY51\WRiaX70doFx\XKrdH;u[YFtdHliaX6gcY92e2ViYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC2dX3vdkBk\WyuIHfyc5d1cCCjdDCxMlYhfG9iMj60JI1oN2upLDDpdEBi\G2rbnnzeIVz\WRib36g[IF6KDFidH:gOEBu\WG|dYLl[EBwdiCmYYmgOUBjgSCqb3zsc5ch\mmkZYKgZZN{[Xl? NXfu[3BORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlcyPDZpPkKxPVY4OTR4PD;hQi=>
NCI-H522 M1jadWFvfGm2dX3vdkBie3OjeR?= NFXIPZQyNjZidH:gNk41KG2pL3vn NFfR[3h2eCC2bzC1JIRigXN? NUPZWYd7SW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUmNKNUh3MkKgZ4VtdHNiaX3wcIFvfGWmIHnueJJieGW{aYTvcoVidGy7IHnuJI1wfXOnIHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidIXtc5Ih[2WubDDndo94fGhiYYSgNU43KHSxIEKuOEBu\y:tZzygbZAh[WSvaX7pd5RmemWmIH;uJIRigSBzIITvJFQhdWWjc4Xy[YQhd25iZHH5JFUh[nliaH;scI94KG[rYnXyJIF{e2G7 NFvaOW09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm2O|E1Pid-MkG5OlcyPDZ:L3G+
OVCAR5 MmLxRY51cXS3bX;yJIF{e2G7 NWf3ZXVzOS54IITvJFIvPCCvZz;r[y=> MmfzeZAhfG9iNTDkZZl{ M3joWmFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF;WR2FTPSClZXzsd{BqdXCuYX70[YQhcW62cnHw[ZJqfG:wZXHscJkhcW5ibX;1d4Uh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB1fW2xcjDj[YxtKGe{b4f0bEBifCBzLk[geI8hOi52IH3nM4toNCCrcDDh[I1qdmm|dHXy[YQhd25iZHH5JFEhfG9iNDDt[YF{fXKnZDDvckBl[XliNTDifUBpd2yub4eg[olj\XJiYYPzZZk> M4PCTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
SW620 NFTpW4VCdnSrdIXtc5Ih[XO|YYm= M{DVc|EvPiC2bzCyMlQhdWdxa3e= NI[1UGx2eCC2bzC1JIRigXN? NV;UfYk6SW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gV3c3OjBiY3XscJMhcW2ybHHueIVlKGmwdILhdIVzcXSxbnXhcIx6KGmwIH3veZNmKGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhfHWvb4KgZ4VtdCCpcn;3eIgh[XRiMT62JJRwKDJwNDDt[{9s\yxiaYCgZYRucW6rc4TldoVlKG:wIHThfUAyKHSxIESgcYVie3W{ZXSgc44h\GG7IEWgZpkhcG:ubH;3JIZq[mW{IHHzd4F6 Mo\DQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkexOFYoRjJzOU[3NVQ3RC:jPh?=
MDA-MB-435 NUDwVINoSW62aYT1cY9zKGG|c3H5 NHTJRWMyNjZidH:gNk41KG2pL3vn MlO0eZAhfG9iNTDkZZl{ NHXaUohCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvNEO1JINmdGy|IHntdIxidnSnZDDpcpRz[XCncnn0c45m[WyueTDpckBud3W|ZTDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIIT1cY9zKGOnbHyg[5Jwf3SqIHH0JFEvPiC2bzCyMlQhdWdxa3esJIlxKGGmbXnubZN1\XKnZDDvckBl[XliMTD0c{A1KG2nYYP1doVlKG:wIHThfUA2KGK7IHjvcIxwfyCoaXLldkBie3OjeR?= MojBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkexOFYoRjJzOU[3NVQ3RC:jPh?=
COLO205 NX;nN4NbSW62aYT1cY9zKGG|c3H5 NInmW4cyNjZidH:gNk41KG2pL3vn NU\p[G5{fXBidH:gOUBl[Xm| NHPMUo5CdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDDU2xQOjB3IHPlcIx{KGmvcHzhcpRm\CCrboTyZZBmemm2b37lZYxtgSCrbjDtc5V{\SCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHS3bX;yJINmdGxiZ4Lve5RpKGG2IEGuOkB1dyB{LkSgcYcwc2duIHnwJIFldWmwaYP0[ZJm\CCxbjDkZZkhOSC2bzC0JI1m[XO3cnXkJI9vKGSjeTC1JIJ6KGixbHzve{BncWKncjDhd5NigQ>? MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl4N{G0Okc,OjF7NkexOFY9N2F-
LOXIMVI MoTqRY51cXS3bX;yJIF{e2G7 MWSxMlYhfG9iMj60JI1oN2up M1PjPJVxKHSxIEWg[IF6ew>? NIjJZ25CdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDMU3hKVV[LIHPlcIx{KGmvcHzhcpRm\CCrboTyZZBmemm2b37lZYxtgSCrbjDtc5V{\SCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHS3bX;yJINmdGxiZ4Lve5RpKGG2IEGuOkB1dyB{LkSgcYcwc2duIHnwJIFldWmwaYP0[ZJm\CCxbjDkZZkhOSC2bzC0JI1m[XO3cnXkJI9vKGSjeTC1JIJ6KGixbHzve{BncWKncjDhd5NigQ>? M3K5bVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
UACC62 NWXteolMSW62aYT1cY9zKGG|c3H5 MkCzNU43KHSxIEKuOEBu\y:tZx?= MXH1dEB1dyB3IHThfZM> MX;BcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDoeY1idiCXQVPDOlIh[2WubIOgbY1xdGGwdHXkJIlvfHKjcHXybZRwdmWjbHz5JIlvKG2xdYPlJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geJVud3JiY3XscEBoem:5dHigZZQhOS54IITvJFIvPCCvZz;r[{whcXBiYXTtbY5qe3SncnXkJI9vKGSjeTCxJJRwKDRibXXhd5Vz\WRib36g[IF6KDViYomgbI9tdG:5IH\pZoVzKGG|c3H5 NFHiTXY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm2O|E1Pid-MkG5OlcyPDZ:L3G+
MDA-MB-231 NWLSc4Z4SW62aYT1cY9zKGG|c3H5 Mn\rNU43KHSxIEKuOEBu\y:tZx?= NIPDdW92eCC2bzC1JIRigXN? M3zF[WFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiaX3wcIFvfGWmIHnueJJieGW{aYTvcoVidGy7IHnuJI1wfXOnIHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidIXtc5Ih[2WubDDndo94fGhiYYSgNU43KHSxIEKuOEBu\y:tZzygbZAh[WSvaX7pd5RmemWmIH;uJIRigSBzIITvJFQhdWWjc4Xy[YQhd25iZHH5JFUh[nliaH;scI94KG[rYnXyJIF{e2G7 M3v1PFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
SF295 NXnT[GF6SW62aYT1cY9zKGG|c3H5 NWGxWYlsOS54IITvJFIvPCCvZz;r[y=> MlLHeZAhfG9iNTDkZZl{ NIDZSHJCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTSlI6PSClZXzsd{BqdXCuYX70[YQhcW62cnHw[ZJqfG:wZXHscJkhcW5ibX;1d4Uh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB1fW2xcjDj[YxtKGe{b4f0bEBifCBzLk[geI8hOi52IH3nM4toNCCrcDDh[I1qdmm|dHXy[YQhd25iZHH5JFEhfG9iNDDt[YF{fXKnZDDvckBl[XliNTDifUBpd2yub4eg[olj\XJiYYPzZZk> MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl4N{G0Okc,OjF7NkexOFY9N2F-
U251 M1HrdmFvfGm2dX3vdkBie3OjeR?= NVfYUHo4OS54IITvJFIvPCCvZz;r[y=> MofCeZAhfG9iNTDkZZl{ MVXBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDoeY1idiCXMkWxJINmdGy|IHntdIxidnSnZDDpcpRz[XCncnn0c45m[WyueTDpckBud3W|ZTDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIIT1cY9zKGOnbHyg[5Jwf3SqIHH0JFEvPiC2bzCyMlQhdWdxa3esJIlxKGGmbXnubZN1\XKnZDDvckBl[XliMTD0c{A1KG2nYYP1doVlKG:wIHThfUA2KGK7IHjvcIxwfyCoaXLldkBie3OjeR?= MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl4N{G0Okc,OjF7NkexOFY9N2F-
OVRAC3 NFTEU5dCdnSrdIXtc5Ih[XO|YYm= NYDMUZRmOS54IITvJFIvPCCvZz;r[y=> MoSweZAhfG9iNTDkZZl{ M1joUmFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF;WVmFEOyClZXzsd{BqdXCuYX70[YQhcW62cnHw[ZJqfG:wZXHscJkhcW5ibX;1d4Uh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB1fW2xcjDj[YxtKGe{b4f0bEBifCBzLk[geI8hOi52IH3nM4toNCCrcDDh[I1qdmm|dHXy[YQhd25iZHH5JFEhfG9iNDDt[YF{fXKnZDDvckBl[XliNTDifUBpd2yub4eg[olj\XJiYYPzZZk> NWPUXHh4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlcyPDZpPkKxPVY4OTR4PD;hQi=>
LLC Mm\oSpVv[3Srb36gZZN{[Xl? MWPJcohq[mm2aX;uJI9nKEiGQVOtcYVlcWG2ZXSgTGlHNTGjbIDoZUBi[3Srdnn0fUBqdiCvb4Xz[UBNVENiY3XscJMtKEmFNUCgQUAzKM7:TT6= MlrkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|MEW2NVIoRjJ{M{C1OlEzRC:jPh?=
NCI-H522 MmrHS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkDiS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUmNKNUh3MkKgZ4VtdHNiYomgd5Vt\m:{aH;kZY1qdmViQjDjc4xwemmvZYTybYMhdWW2aH;kMEBIUTVyIE2gNE4xODF6IN88UU4> MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{[zPEc,OjN|MUO2N|g9N2F-
LOXIMVI NEDiNZJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkjFS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUG9ZUU2YSTDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHPvcI9zcW2ndILpZ{Bu\XSqb3SsJGdKPTBiPTCwMlAxOjVizszNMi=> MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{[zPEc,OjN|MUO2N|g9N2F-
A549 M{XvNGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1HVZWdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGE2PDliY3XscJMh[nlic4Xs[o9zcG:mYX3pcoUhSiClb3zvdolu\XS{aXOgcYV1cG:mLDDHTVUxKD1iMD6wNFI3KM7:TT6= MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{[zPEc,OjN|MUO2N|g9N2F-
OVCAR5 NVTDeJViT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mo\IS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gU3ZESVJ3IHPlcIx{KGK7IIP1cIZwemixZHHtbY5mKEJiY3;sc5JqdWW2cnnjJI1mfGixZDygS2k2OCB;IECuNFAzQCEQvF2u MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{[zPEc,OjN|MUO2N|g9N2F-
MKN74 MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIXzSJZIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBOU055NDDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHPvcI9zcW2ndILpZ{Bu\XSqb3SsJGdKPTBiPTCwMlAxOyEQvF2u MnXZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MUO2N|goRjJ|M{GzOlM5RC:jPh?=
NCI-H460 MYXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mn7YS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUmNKNUh2NkCgZ4VtdHNiYomgd5Vt\m:{aH;kZY1qdmViQjDjc4xwemmvZYTybYMhdWW2aH;kMEBIUTVyIE2gNE4xODNizszNMi=> MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{[zPEc,OjN|MUO2N|g9N2F-
HCT116 M4\k[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoXMS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gTGNVOTF4IHPlcIx{KGK7IIP1cIZwemixZHHtbY5mKEJiY3;sc5JqdWW2cnnjJI1mfGixZDygS2k2OCB;IECuNFA{OSEQvF2u M{LKNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{GzOlM5Lz5{M{OxN|Y{QDxxYU6=
HCC2998 NYj3N4hyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnHZS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gTGNEOjl7ODDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHPvcI9zcW2ndILpZ{Bu\XSqb3SsJGdKPTBiPTCwMlAxOzFizszNMi=> MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{[zPEc,OjN|MUO2N|g9N2F-
MKN1 MYDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYTHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDNT24yKGOnbHzzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[2:ub4LpcYV1emmlIH3leIhw\CxiR1m1NEA:KDBwMECzNkDPxE1w MoDSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MUO2N|goRjJ|M{GzOlM5RC:jPh?=
SKOV3 MYfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnP4S5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gV2tQXjNiY3XscJMh[nlic4Xs[o9zcG:mYX3pcoUhSiClb3zvdolu\XS{aXOgcYV1cG:mLDDHTVUxKD1iMD6wNFM{KM7:TT6= M{G2SFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{GzOlM5Lz5{M{OxN|Y{QDxxYU6=
HT-29 M3Xydmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnjtS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gTHQuOjliY3XscJMh[nlic4Xs[o9zcG:mYX3pcoUhSiClb3zvdolu\XS{aXOgcYV1cG:mLDDHTVUxKD1iMD6wNFM{KM7:TT6= NY\4SY97RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNVM3OzhpPkKzN|E{PjN6PD;hQi=>
KM12 MWLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHvSOndIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBMVTF{IHPlcIx{KGK7IIP1cIZwemixZHHtbY5mKEJiY3;sc5JqdWW2cnnjJI1mfGixZDygS2k2OCB;IECuNFA{PCEQvF2u MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{[zPEc,OjN|MUO2N|g9N2F-
DMS114 NYq2dXpxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkXXS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gSG1UOTF2IHPlcIx{KGK7IIP1cIZwemixZHHtbY5mKEJiY3;sc5JqdWW2cnnjJI1mfGixZDygS2k2OCB;IECuNFA{PiEQvF2u NXe1bJlXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNVM3OzhpPkKzN|E{PjN6PD;hQi=>
SF539 NW\tNnF7T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIO5NnNIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBUTjV|OTDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHPvcI9zcW2ndILpZ{Bu\XSqb3SsJGdKPTBiPTCwMlAxOzZizszNMi=> MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{[zPEc,OjN|MUO2N|g9N2F-
U251 NXnYXGQ4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4W4fGdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJHUzPTFiY3XscJMh[nlic4Xs[o9zcG:mYX3pcoUhSiClb3zvdolu\XS{aXOgcYV1cG:mLDDHTVUxKD1iMD6wNFM6KM7:TT6= NX\DWnV1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNVM3OzhpPkKzN|E{PjN6PD;hQi=>
SF295 NVfwfIlDT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnLBS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gV2YzQTViY3XscJMh[nlic4Xs[o9zcG:mYX3pcoUhSiClb3zvdolu\XS{aXOgcYV1cG:mLDDHTVUxKD1iMD6wNFQh|ryPLh?= NGmwUmE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OxN|Y{QCd-MkOzNVM3Ozh:L3G+
MCF7 NEnjRXJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4XmeGdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG1ETjdiY3XscJMh[nlic4Xs[o9zcG:mYX3pcoUhSiClb3zvdolu\XS{aXOgcYV1cG:mLDDHTVUxKD1iMD6wNFQzKM7:TT6= NF3GS3Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OxN|Y{QCd-MkOzNVM3Ozh:L3G+
NCI-H23 NXjuV4M3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2XhfGdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkOgZ4VtdHNiYomgd5Vt\m:{aH;kZY1qdmViQjDjc4xwemmvZYTybYMhdWW2aH;kMEBIUTVyIE2gNE4xODR4IN88UU4> NYD5WZp[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNVM3OzhpPkKzN|E{PjN6PD;hQi=>
OVCAR3 NH7ld5VIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWDKNWVWT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hV1[FQWKzJINmdGy|IHL5JJN2dG[xcnjv[IFucW6nIFKgZ49td3KrbXX0dolkKG2ndHjv[EwhT0l3MDC9JFAvODB2NjFOwG0v MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{[zPEc,OjN|MUO2N|g9N2F-
MKN7 MVXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NF;BOVdIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBOU055IHPlcIx{KGK7IIP1cIZwemixZHHtbY5mKEJiY3;sc5JqdWW2cnnjJI1mfGixZDygS2k2OCB;IECuNFA1QSEQvF2u MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{[zPEc,OjN|MUO2N|g9N2F-
SF268 M3rtbGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGjtVo1Iem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBUTjJ4ODDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHPvcI9zcW2ndILpZ{Bu\XSqb3SsJGdKPTBiPTCwMlAxPDlizszNMi=> MmXCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MUO2N|goRjJ|M{GzOlM5RC:jPh?=
MDA-MB-231 MlTFS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYHHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHL5JJN2dG[xcnjv[IFucW6nIFKgZ49td3KrbXX0dolkKG2ndHjv[EwhT0l3MDC9JFAvODB3NTFOwG0v M1KxOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{GzOlM5Lz5{M{OxN|Y{QDxxYU6=
OVCAR8 MVLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4nPfGdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG9XS0GUODDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHPvcI9zcW2ndILpZ{Bu\XSqb3SsJGdKPTBiPTCwMlAxPTVizszNMi=> MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{[zPEc,OjN|MUO2N|g9N2F-
DMS273 NHnHSFZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmP5S5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gSG1UOjd|IHPlcIx{KGK7IIP1cIZwemixZHHtbY5mKEJiY3;sc5JqdWW2cnnjJI1mfGixZDygS2k2OCB;IECuNFA2QCEQvF2u M{XiSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{GzOlM5Lz5{M{OxN|Y{QDxxYU6=
DU145 MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmDLS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gSHUyPDViY3XscJMh[nlic4Xs[o9zcG:mYX3pcoUhSiClb3zvdolu\XS{aXOgcYV1cG:mLDDHTVUxKD1iMD6wNFYh|ryPLh?= NUTWS5BpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNVM3OzhpPkKzN|E{PjN6PD;hQi=>
RXF631L M37Id2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mkm4S5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gVnhHPjNzTDDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHPvcI9zcW2ndILpZ{Bu\XSqb3SsJGdKPTBiPTCwMlAxPjZizszNMi=> M{O4SFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{GzOlM5Lz5{M{OxN|Y{QDxxYU6=
HBC4 NYTG[m85T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1nHbWdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGhDSzRiY3XscJMh[nlic4Xs[o9zcG:mYX3pcoUhSiClb3zvdolu\XS{aXOgcYV1cG:mLDDHTVUxKD1iMD6wNFY6KM7:TT6= M{K4UVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{GzOlM5Lz5{M{OxN|Y{QDxxYU6=
SNB75 MluyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3Lrc2dzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJHNPSjd3IHPlcIx{KGK7IIP1cIZwemixZHHtbY5mKEJiY3;sc5JqdWW2cnnjJI1mfGixZDygS2k2OCB;IECuNFA4OiEQvF2u NUjxXWh[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNVM3OzhpPkKzN|E{PjN6PD;hQi=>
BSY1 NUT6XGVwT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NX7sfoFlT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hSlO\MTDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHPvcI9zcW2ndILpZ{Bu\XSqb3SsJGdKPTBiPTCwMlAxQDVizszNMi=> MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{[zPEc,OjN|MUO2N|g9N2F-
NCI-H226 M4PJ[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MljMS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUmNKNUh{Mk[gZ4VtdHNiYomgd5Vt\m:{aH;kZY1qdmViQjDjc4xwemmvZYTybYMhdWW2aH;kMEBIUTVyIE2gNE4xODh7IN88UU4> M1;qSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{GzOlM5Lz5{M{OxN|Y{QDxxYU6=
SNB78 MmjOS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEK2bpRIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBUVkJ5ODDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHPvcI9zcW2ndILpZ{Bu\XSqb3SsJGdKPTBiPTCwMlAxQTZizszNMi=> Mne1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MUO2N|goRjJ|M{GzOlM5RC:jPh?=
HBC5 NXXveGFuT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVTVNHVIT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUEKFNTDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHPvcI9zcW2ndILpZ{Bu\XSqb3SsJGdKPTBiPTCwMlAyOyEQvF2u NEG3Tpk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OxN|Y{QCd-MkOzNVM3Ozh:L3G+
MKN45 M4e4fWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mnq1S5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUWtPPDViY3XscJMh[nlic4Xs[o9zcG:mYX3pcoUhSiClb3zvdolu\XS{aXOgcYV1cG:mLDDHTVUxKD1iMD6wNVQh|ryPLh?= M1r1TVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{GzOlM5Lz5{M{OxN|Y{QDxxYU6=
MKN28 NX;kXVlOT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkfpS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUWtPOjhiY3XscJMh[nlic4Xs[o9zcG:mYX3pcoUhSiClb3zvdolu\XS{aXOgcYV1cG:mLDDHTVUxKD1iMD6wNVch|ryPLh?= MoG0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MUO2N|goRjJ|M{GzOlM5RC:jPh?=
PC3 MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVLtNIVuT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hWEN|IHPlcIx{KGK7IIP1cIZwemixZHHtbY5mKEJiY3;sc5JqdWW2cnnjJI1mfGixZDygS2k2OCB;IECuNFE5KM7:TT6= NFztZmE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OxN|Y{QCd-MkOzNVM3Ozh:L3G+
ACHN MX\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWLHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDBR2hPKGOnbHzzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[2:ub4LpcYV1emmlIH3leIhw\CxiR1m1NEA:KDBwMEKg{txONg>? MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{[zPEc,OjN|MUO2N|g9N2F-
OVCAR4 NEPV[npIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnHGS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gU3ZESVJ2IHPlcIx{KGK7IIP1cIZwemixZHHtbY5mKEJiY3;sc5JqdWW2cnnjJI1mfGixZDygS2k2OCB;IECuNFIh|ryPLh?= M1;EdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{GzOlM5Lz5{M{OxN|Y{QDxxYU6=
St-4 MYDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUjHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDTeE01KGOnbHzzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[2:ub4LpcYV1emmlIH3leIhw\CxiR1m1NEA:KDBwMEKyJO69VS5? MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{[zPEc,OjN|MUO2N|g9N2F-
HCT15 MYPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWDiRZd3T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUEOWMUWgZ4VtdHNiYomgd5Vt\m:{aH;kZY1qdmViQjDjc4xwemmvZYTybYMhdWW2aH;kMEBIUTVyIE2gNE41PSEQvF2u NWTuTJN5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNVM3OzhpPkKzN|E{PjN6PD;hQi=>
CD4+ T M{fr[WZ2dmO2aX;uJIF{e2G7 NG\4eGg4KGSjeYO= Ml7LVoVi[3SrdnH0bY9vKG:oIHzheIVvfCCKSW[xJG5NPC1|LVz1Z{BmgHC{ZYPzbY9vKGmwIHj1cYFvKG6jaY\lJGNFPCtiVDDj[YxteyC2cnXheIVlKDdiZHH5d{Bxd3O2LXnu[oVkfGmxbjDt[YF{fXKnZDDh[pRmeiB2ODDodpMh[nlibIXtbY5me2OnbnPlJJBt[XSnIILlZYRmeiCjbnHsfZNqeyxiRVO1NEA:KDBwMECzJO69VS5? NH:xd5g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NES5OVExPSd-MkS0PVUyODV:L3G+
NCI-H522 NV\hUI93S3m2b4TvfIlkcXS7IHHzd4F6 NInPVlhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBPS0lvSEWyNkBk\WyuczDifUBUWkJiYYPzZZktKEeLNUCgQUAxNjByMUig{txONg>? MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
LOXIMVI M17oN2N6fG:2b4jpZ4l1gSCjc4PhfS=> NF\6TIJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBNV1iLTW\JJINmdGy|IHL5JHNTSiCjc4PhfUwhT0l3MDC9JFAvODB{NTFOwG0v NEnPbZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW4PVQ5Pid-MkS1PFk1QDZ:L3G+
A549 NG\jeJZEgXSxdH;4bYNqfHliYYPzZZk> NGL3flhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFAzPiEQvF2u NInrem49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW4PVQ5Pid-MkS1PFk1QDZ:L3G+
OVCAR5 M{[xUGN6fG:2b4jpZ4l1gSCjc4PhfS=> M4mzUWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG9XS0GUNTDj[YxteyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAxOjhizszNMi=> MkLVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEm0PFYoRjJ2NUi5OFg3RC:jPh?=
NCI-H460 NGPwbVZEgXSxdH;4bYNqfHliYYPzZZk> M1P3N2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5EUS2KNE[wJINmdGy|IHL5JHNTSiCjc4PhfUwhT0l3MDC9JFAvODB|IN88UU4> MkHJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEm0PFYoRjJ2NUi5OFg3RC:jPh?=
MKN74 M1f2XmN6fG:2b4jpZ4l1gSCjc4PhfS=> NFLZSnBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOU055NDDj[YxteyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAxOyEQvF2u M1fkb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUi5OFg3Lz5{NEW4PVQ5PjxxYU6=
HCC2998 NHzMeIdEgXSxdH;4bYNqfHliYYPzZZk> NGHRT5hEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJS0N{OUm4JINmdGy|IHL5JHNTSiCjc4PhfUwhT0l3MDC9JFAvODB|MTFOwG0v MoPwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEm0PFYoRjJ2NUi5OFg3RC:jPh?=
HCT116 NYjXZYluS3m2b4TvfIlkcXS7IHHzd4F6 NXSxVpNqS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEOWMUG2JINmdGy|IHL5JHNTSiCjc4PhfUwhT0l3MDC9JFAvODB|MTFOwG0v Ml31QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEm0PFYoRjJ2NUi5OFg3RC:jPh?=
MKN1 Mkj3R5l1d3SxeHnjbZR6KGG|c3H5 M4HxW2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1MVjFiY3XscJMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMD6wNFMzKM7:TT6= MmKwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEm0PFYoRjJ2NUi5OFg3RC:jPh?=
HT-29 M3TPSmN6fG:2b4jpZ4l1gSCjc4PhfS=> NFTvcXBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJXC1{OTDj[YxteyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAxOzNizszNMi=> M2XpfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUi5OFg3Lz5{NEW4PVQ5PjxxYU6=
SKOV3 M4LXR2N6fG:2b4jpZ4l1gSCjc4PhfS=> M2ri[2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMV1Z|IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFA{OyEQvF2u NHP4U2Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW4PVQ5Pid-MkS1PFk1QDZ:L3G+
KM12 M3fG[mN6fG:2b4jpZ4l1gSCjc4PhfS=> NFjONYpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMVTF{IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFA{PCEQvF2u MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
SF539 MoH6R5l1d3SxeHnjbZR6KGG|c3H5 MVTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTSlU{QSClZXzsd{BjgSCVUlKgZZN{[XluIFfJOVAhRSByLkCwN|Yh|ryPLh?= NVflbmlwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
293T M33DUGZ2dmO2aX;uJIF{e2G7 M17IR|MxKG2rboO= MoDRTY5pcWKrdHnvckBw\iCqdX3hckBJTEGFMTDlfJBz\XO|ZXSgbY4hcHWvYX6gNlk{XCClZXzsd{B2e2mwZzDBZ{1MT0yJSzjBZ{kuVUODIHHzJJN2[nO2cnH0[UBi\nSncjCzNEBucW6|IHL5JIZtfW:{ZYPj[Y5k\SCjc4PhfUwhUUN3MDC9JFAvODB|NjFOwG0v Mo\PQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEm0PFYoRjJ2NUi5OFg3RC:jPh?=
DMS114 MmDFR5l1d3SxeHnjbZR6KGG|c3H5 MY\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDEUXMyOTRiY3XscJMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMD6wNFM3KM7:TT6= MnfSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEm0PFYoRjJ2NUi5OFg3RC:jPh?=
U251 MXzDfZRwfG:6aXPpeJkh[XO|YYm= M4jsdmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHUzPTFiY3XscJMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMD6wNFM6KM7:TT6= MmfTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEm0PFYoRjJ2NUi5OFg3RC:jPh?=
SF295 MUjDfZRwfG:6aXPpeJkh[XO|YYm= MXnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTSlI6PSClZXzsd{BjgSCVUlKgZZN{[XluIFfJOVAhRSByLkCwOEDPxE1w M4\4blxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUi5OFg3Lz5{NEW4PVQ5PjxxYU6=
MCF7 NHn3RYdEgXSxdH;4bYNqfHliYYPzZZk> NH\Od49EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFA1OiEQvF2u M4TRflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUi5OFg3Lz5{NEW4PVQ5PjxxYU6=
OVCAR3 M1O1SmN6fG:2b4jpZ4l1gSCjc4PhfS=> Mo\qR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gU3ZESVJ|IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFA1PiEQvF2u NVjqV4diRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
NCI-H23 M4nrc2N6fG:2b4jpZ4l1gSCjc4PhfS=> NGW2RZREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBPS0lvSEKzJINmdGy|IHL5JHNTSiCjc4PhfUwhT0l3MDC9JFAvODB2NjFOwG0v MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
SF268 NHvYWXVEgXSxdH;4bYNqfHliYYPzZZk> NVfwZXc3S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0Z{NkigZ4VtdHNiYomgV3JDKGG|c3H5MEBIUTVyIE2gNE4xODR7IN88UU4> NXjrepZ4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
MKN7 NHfINHREgXSxdH;4bYNqfHliYYPzZZk> NHnLOHpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOU055IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFA1QSEQvF2u MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
OVCAR8 NHOwRVJEgXSxdH;4bYNqfHliYYPzZZk> M3TVRWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG9XS0GUODDj[YxteyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAxPTVizszNMi=> NFf3ZZo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW4PVQ5Pid-MkS1PFk1QDZ:L3G+
MDA-MB-231 NYDsVYtyS3m2b4TvfIlkcXS7IHHzd4F6 MmC0R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDifUBUWkJiYYPzZZktKEeLNUCgQUAxNjByNUWg{txONg>? NFrOSms9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW4PVQ5Pid-MkS1PFk1QDZ:L3G+
DMS273 NIG3d4VEgXSxdH;4bYNqfHliYYPzZZk> NIr3dVlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBFVVN{N{OgZ4VtdHNiYomgV3JDKGG|c3H5MEBIUTVyIE2gNE4xODV6IN88UU4> MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
DU145 NWDqb4R5S3m2b4TvfIlkcXS7IHHzd4F6 MVjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{BjgSCVUlKgZZN{[XluIFfJOVAhRSByLkCwOkDPxE1w NIfkPWU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW4PVQ5Pid-MkS1PFk1QDZ:L3G+
RXF631L NHTHcYxEgXSxdH;4bYNqfHliYYPzZZk> MnH3R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVnhHPjNzTDDj[YxteyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAxPjZizszNMi=> MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
HBC4 NFWyRo1EgXSxdH;4bYNqfHliYYPzZZk> M1H5WWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhDSzRiY3XscJMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMD6wNFY6KM7:TT6= NFfMN4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW4PVQ5Pid-MkS1PFk1QDZ:L3G+
SNB75 NV;tTII4S3m2b4TvfIlkcXS7IHHzd4F6 M1\rWGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNPSjd3IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFA4OiEQvF2u MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
BSY1 NH21SnVEgXSxdH;4bYNqfHliYYPzZZk> MYXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDCV3kyKGOnbHzzJIJ6KFOUQjDhd5NigSxiR1m1NEA:KDBwMEC4OUDPxE1w NXzDUJBKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
NCI-H226 MUjDfZRwfG:6aXPpeJkh[XO|YYm= NWn3NHluS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVkOLLViyNlYh[2WubIOgZpkhW1KEIHHzd4F6NCCJSUWwJF0hOC5yMEi5JO69VS5? NHXYWnA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW4PVQ5Pid-MkS1PFk1QDZ:L3G+
SNB78 MWLDfZRwfG:6aXPpeJkh[XO|YYm= NHraN41EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUVkJ5ODDj[YxteyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAxQTZizszNMi=> MkDkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEm0PFYoRjJ2NUi5OFg3RC:jPh?=
HBC5 NVnE[no3S3m2b4TvfIlkcXS7IHHzd4F6 MVPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIRmM2KGOnbHzzJIJ6KFOUQjDhd5NigSxiR1m1NEA:KDBwMEGzJO69VS5? M1nRSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUi5OFg3Lz5{NEW4PVQ5PjxxYU6=
MKN45 MW\DfZRwfG:6aXPpeJkh[XO|YYm= Mm\pR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWtPPDViY3XscJMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMD6wNVQh|ryPLh?= Mnq2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEm0PFYoRjJ2NUi5OFg3RC:jPh?=
MKN28 NF7qRXBEgXSxdH;4bYNqfHliYYPzZZk> MV\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNT24zQCClZXzsd{BjgSCVUlKgZZN{[XluIFfJOVAhRSByLkCxO{DPxE1w M4myVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUi5OFg3Lz5{NEW4PVQ5PjxxYU6=
PC3 NYfZZ21ZS3m2b4TvfIlkcXS7IHHzd4F6 NYPmTmlOS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEN|IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFE5KM7:TT6= NHzafHM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW4PVQ5Pid-MkS1PFk1QDZ:L3G+
ACHN NGLxRldEgXSxdH;4bYNqfHliYYPzZZk> NILGUINEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCS0iQIHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFIh|ryPLh?= NUPjZlByRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
OVCAR4 MWfDfZRwfG:6aXPpeJkh[XO|YYm= Mn7jR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gU3ZESVJ2IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFIh|ryPLh?= MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
St-4 MnXpR5l1d3SxeHnjbZR6KGG|c3H5 MUjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTeE01KGOnbHzzJIJ6KFOUQjDhd5NigSxiR1m1NEA:KDBwMEKyJO69VS5? MmLKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEm0PFYoRjJ2NUi5OFg3RC:jPh?=
293T NIC2VVhHfW6ldHnvckBie3OjeR?= MYizNEBucW6| NWm3W4dJUW6qaXLpeIlwdiCxZjDtc5V{\SCKRFHDOkBmgHC{ZYPz[YQhcW5iaIXtZY4hOjl|VDDj[YxteyC3c3nu[{BC[y2NR1zHT{hC[ylvTVPBJIF{KHO3YoP0doF1\SCjZoTldkA{OCCvaX7zJIJ6KG[udX;y[ZNk\W6lZTDhd5NigSxiSVO1NEA:KDBwM{mg{txONg>? NFH4PGs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW4PVQ5Pid-MkS1PFk1QDZ:L3G+
HCT15 NU\hOlZsS3m2b4TvfIlkcXS7IHHzd4F6 NEDiR3REgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJS1RzNTDj[YxteyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlQ2KM7:TT6= NITYc2k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW4PVQ5Pid-MkS1PFk1QDZ:L3G+
mink Mv1Lu MVfGeY5kfGmxbjDhd5NigQ>? Mm\uNlQhcHK| NHjlVJBKdmO{ZXHz[UBqdiCqdX3hckB4cWymIIT5dIUheDJzIIDyc5RmcW5iZYjwdoV{e2mxbjDpckBucW6tIF32NWx2KGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDwNlEheHKxbX;0[ZIh[XO|YYmgbY4heHKnc3XuZ4Uhd2ZiMD6xJI1OKGSrdHjpc5RpemWrdH;sMEBGSzFyMECgQUAxNjBzNUeg{txONg>? M37MWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUm3OVc5Lz5{NEm5O|U4QDxxYU6=
HCT116 MWnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MVK0PEBpenN? MYXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEGxOkBk\WyuczDh[pRmeiB2ODDodpMhcW5icILld4Vv[2Vib3[gSHRVKGK7IF3UWEBie3OjeTygTWM2OCB;IECuNFA{KM7:TT6= M4PBSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MUS3OlEzLz5{NUG0O|YyOjxxYU6=
MOLT4 NX3wbGZsSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M1rUSFczKGi{cx?= MXvBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2RTGS0JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCFQ1u4JIF{e2G7LDDHTVUxKD1iMD6wNFIxPiEQvF2u NXnpfollRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zN|E{OzRpPkK2N|MyOzN2PD;hQi=>
DU145 NFr1d25CdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M{G3U|czKGi{cx?= MUjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKESXMUS1JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCFQ1u4JIF{e2G7LDDHTVUxKD1iMD6wNFI2PSEQvF2u NUnWPHBURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zN|E{OzRpPkK2N|MyOzN2PD;hQi=>
U937 NHnCVFhCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NX;4TY1uPzJiaILz MY\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFV7M{egZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KEOFS{igZZN{[XluIFfJOVAhRSByLkCwN|QyKM7:TT6= NGrQOmM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkOzNVM{PCd-Mk[zN|E{OzR:L3G+
HLF M2q3NGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MmD5O|IhcHK| M{PRV2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFzGJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCFQ1u4JIF{e2G7LDDHTVUxKD1iMD6wNFQ5QSEQvF2u MorxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ|M{GzN|QoRjJ4M{OxN|M1RC:jPh?=
WI38 MV;BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MkPxO|IhcHK| MWnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFeLM{igZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KEOFS{igZZN{[XluIFfJOVAhRSByLkCwOVM6KM7:TT6= MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjN|MUOzOEc,OjZ|M{GzN|Q9N2F-
U937 NIjQS2lHfW6ldHnvckBie3OjeR?= MYiyOEBpenN? MlHUTY5pcWKrdHnvckBw\iCKRFHDOkBqdiCqdX3hckBWQTN5IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDv[kBidHCqYT30eYJqdGmwIHHj[ZR6dGG2aX;uJIF1KDVibl2geI8hPSC3TTDh[pRmeiB{NDDodpMh[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz MlraQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ|M{GzN|QoRjJ4M{OxN|M1RC:jPh?=
HCT116 NWnQOXJ3SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NX\OT2NTPzJiaILz NF7WfXJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFEyPiClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDjc5VtfGW{IHPveY51\XJibXX0bI9lNCCLQ{WwJF0hOC5yMkig{txONg>? MkiyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2OEG2OVkoRjJ4NEixOlU6RC:jPh?=
IGROV1/Pt1 MUDBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NWjMfmdYPzJiaILz MWTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEmJUl;WNU9RfDFiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkhcW6ldXLheIVlKG[xcjC3NkBpenNiYomgZ492dHSncjDjc5VvfGW{IH3leIhw\CxiSVO1NEA:KDBwMEig{txONg>? NWS2eI1DRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0PFE3PTlpPkK2OFgyPjV7PD;hQi=>
IGROV1 NEjvXmNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NUfBTFM4PzJiaILz Mm\NRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCLR2LPWlEh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImgbY5kfWKjdHXkJIZweiB5MjDodpMh[nliY3;1cJRmeiClb4XueIVzKG2ndHjv[EwhUUN3MDC9JFAvOjJizszNMi=> M3nFSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NEixOlU6Lz5{NkS4NVY2QTxxYU6=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p21 / Cyclin D1; 

PubMed: 19682393     


NIH 3T3 cells stably expressing the indicated proteins were treated with DMSO (Vehicle) or the indicated concentration of romidepsin for 24 h. Cell lysates were analyzed by western blotting with antibodies to cyclin D1, p21 and β-actin (loading control). Data shown are representative of at least two independent experiments.

AcH3(K9) / Ac-α-Tubulin(K40) / Ac-NFκB2(K310) p65 / 3MeH3(K27); 

PubMed: 26473529     


Effects of romidepsin (Rom) on the levels of acetylated proteins and related enzymes. Cells were exposed to romidepsin for 48 h and total cell extracts were analyzed by western blot.

HDAC3 / HDAC4 / HDAC6 / HDAC2; 

PubMed: 26473529     


Effects of romidepsin (Rom) on the levels of acetylated proteins and related enzymes. Cells were exposed to romidepsin for 48 h and total cell extracts were analyzed by western blot.

γH2AX / PARP1 / Cleaved caspase3 / BAK / p21(waf1/cip1) / XIAP; 

PubMed: 26473529     


Western blot analysis of proteins involved in DNA-damage response and apoptosis. Established cell lines were exposed to different concentrations of romidepsin (Rom) for 48 h and total cell extracts were analyzed.

Cyclin E1 / BRCA1 / E2F1 / Cleaved PARP / H3Ac; 

PubMed: 27444036     


Western blot analysis of the effects of panobinostat (25 nM), vorinostat (5 µM) and romidepsin (10 nM) on expression of cyclin E1, E2F1, BRCA1, cleaved PARP and acetylated histone H3 in OVCAR-3 cells. Actin and histone H3 were loading controls. 

pAKT(S473) / pAKT(T308) / AKT; 

PubMed: 25492515     


Western blot analysis of phosphorylated AKT in PC3 cells. Cells were treated for 3 h with various concentrations of FK228. 

19682393 26473529 27444036 25492515
Growth inhibition assay
Cell viability; 

PubMed: 27444036     


Concentration-dependent effects of panobinostat and vorinostat in SRB viability assays in OVCAR-3 cells (72 h). Values are mean+SE of 3 independent experiments. 

27444036
Immunofluorescence
SS18/TLE1; 

PubMed: 27120803     


A significant decrease in detectable PLA signal following HDAC inhibition in SYO-1 cells.

Cleaved caspase-3; 

PubMed: 22531354     


TDP-B activates cleaved caspase-3 by immunofluorescence. Representative immunofluorescence staining for cleaved caspase 3 (green) in SKOV-3 ovarian cancer cells treated with 10 nM FK228, TDP-A or TDP-B after 24 h of exposure. The nuclei are stained with DAPI (blue).

27120803 22531354
体内研究 与PBS处理的对照组相比,单独使用Erlotinib 和 Romidepsin分别可以对NCI-H1299细胞系的异种移植生长抑制到72% 和 43% ,但是并不具有明显的统计学意义。只有当两种药物联用的时候才会对其生长造成明显的抑制作用,此时生长被抑制到28% [1]。在免疫功能低下的小鼠中,Romidepsin 会抑制皮下NB 异种移植的生长,这种抑制作用具有剂量依赖的特性 。此外, 在NB病人的肿瘤组织中Romidepsin 会诱导某些基因的表达,如 p21 和p75 以及NTRK (TrkA) [2]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

- 合并

HDAC-inhibitory activity:

For the enzyme assay, 10 μL of [3H]acetyl-labeled histones (25,000 cpm/10 μg) are added to 90 μL of the HDAC enzyme fraction extracted from 293T cells overexpressing HDAC1 or HDAC2 in the presence of increasing concentrations of Romidepsin, and the mixture is incubated at 37 °C for 15 minutes. The enzyme reaction is linear for at least 1 hour. The reaction is stopped by the addition of 10 μL of concentrated HCl. The released [3H]acetic acid is extracted with 1 mL of ethylacetate, and 0.9 mL of the solvent layer is taken into 5 mL of aqueous counting scintillant II solution for determination of radioactivity. The IC50 values are determined from at least three independent dose-response curves.
细胞实验:[3]
- 合并
  • Cell lines: NCI-H1975, NCI-H157, NCI-2882, NCI-H460 和 HCC95 细胞系
  • Concentrations: 1 ng/mL
  • Incubation Time: 72 小时
  • Method: 使用MTS法分析药物敏感性。在96孔平板中每孔接种2×103个细胞(包括NCI-H1975, NCI-H157, NCI-2882, NCI-H460和HCC95) 。24小时后, 在存在或者缺少1 ng/mL Romidepsin的条件下将细胞与不同浓度 (0.01 µM - 250 µM) 的Erlotinib 37°C 孵育72 小时。 MTS 溶液加到每个孔中37°C孵育1小时。利用分光光度计测量490 nm 处的光密度值。每种药物浓度的实验都设置8个复孔并重复两次。基于细胞生存曲线的吸光度值计算药物的半抑制浓度 (IC50) 。
    (Only for Reference)
动物实验:[5]
- 合并
  • Animal Models: 携带NCI-H1299 细胞的 BALB/c无胸腺裸小鼠
  • Dosages: 1.2 mg/kg
  • Administration: 腹腔注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 10 mg/mL (18.49 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
2% DMSO+30% PEG 300+5%Tween 80+ddH2O
5mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 540.7
化学式

C24H36N4O6S2

CAS号 128517-07-7
储存条件 粉状
溶于溶剂
别名 FR 901228, NSC 630176

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03770000 Active not recruiting Drug: Tenalisib|Drug: Romidepsin T Cell Lymphoma Rhizen Pharmaceuticals SA March 12 2019 Phase 1|Phase 2
NCT02616965 Recruiting Drug: Romidepsin|Drug: Brentuximab vedotin Cutaneous T-cell Lymphoma (CTCL) Fox Chase Cancer Center|Seagen Inc.|Celgene Corporation February 22 2017 Phase 1
NCT02616874 Completed Drug: MVA.HIVconsv vaccine|Drug: Romidepsin HIV IrsiCaixa|Germans Trias i Pujol Hospital|Fundación FLS de Lucha Contra el Sida las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia|Hospital Clinic of Barcelona|Hospital de Sant Pau|HIVACAT|University of Oxford|BCN Checkpoint February 2016 Phase 1
NCT03141203 Active not recruiting Drug: Romidepsin|Drug: Carfilzomib Peripheral T Cell Lymphoma University of Birmingham|Bloodwise|Celgene|Amgen July 13 2015 Phase 1|Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

HDAC Signaling Pathway Map

HDAC Inhibitors with Unique Features

相关HDAC产品

Tags: 购买Romidepsin (FK228, Depsipeptide) | Romidepsin (FK228, Depsipeptide)供应商 | 采购Romidepsin (FK228, Depsipeptide) | Romidepsin (FK228, Depsipeptide)价格 | Romidepsin (FK228, Depsipeptide)生产 | 订购Romidepsin (FK228, Depsipeptide) | Romidepsin (FK228, Depsipeptide)代理商
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID