Romidepsin (FK228, Depsipeptide)

For research use only. Not for use in humans.

目录号:S3020 别名: FR 901228, NSC 630176 中文名称:罗米地辛

Romidepsin (FK228, Depsipeptide) Chemical Structure

CAS No. 128517-07-7

Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176)是一种有效的HDAC1HDAC2抑制剂,无细胞试验中IC50分别为36 nM和47 nM。Romidepsin (FK228/depsipeptide) 在神经母细胞瘤肿瘤细胞中可控制生长并诱导凋亡。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 13415.22 现货
RMB 1285.83 现货
RMB 6445.57 现货
RMB 12858.74 现货
有超大折扣

今日订购,明日送达,全国免运费!

全国免费电话:400-668-6834   |   Email:info@selleck.cn

客户使用Selleck生产的Romidepsin (FK228, Depsipeptide)发表文献136篇:

产品安全说明书

HDAC抑制剂选择性比较

生物活性

产品描述 Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176)是一种有效的HDAC1HDAC2抑制剂,无细胞试验中IC50分别为36 nM和47 nM。Romidepsin (FK228/depsipeptide) 在神经母细胞瘤肿瘤细胞中可控制生长并诱导凋亡。
特性 Romidepsin对I型HDAC的抑制作用明显强于对II型HDAC的抑制。
靶点
HDAC1 [1]
(Cell-free assay)
HDAC2 [1]
(Cell-free assay)
36 nM 47 nM
体外研究

Romidepsin抑制NSCLC细胞系生长,IC50范围从1.3 ng/mL到4.9 ng/mL。 Romidepsin可以降低Erlotinib对NSCLC细胞系的IC50值, 增加NSCLC细胞系对Erlotinib的敏感性[1]。Romidepsin处理72小时可以抑制6/6 人 NB 肿瘤细胞系的生长,而 NIH3T3细胞系并不受影响。 Romidepsin对于单拷贝或N-myc 多拷贝的NB细胞系以及含有正常或突变的p53 和含有Alk突变体的细胞系都有选择性的细胞毒性,这种毒性具有剂量依赖的特性。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
SU-DHL4 NUHyNJAyS2WubDDWbYFjcWyrdImgRZN{[Xl? M2Hkc|IvPS1zNTDuUS=> MoP3O|IhcA>? NGjQd3pqdmS3Y3XzJIN6fG:2b4jpZ4l1gSCrbjDhJINwdmOnboTyZZRqd25vZHXw[Y5l\W62IH3hco5mesLi NHr5T4E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe5NFkxPyd-MkW3PVA6ODd:L3G+
U2932  MWXD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MUmyMlUuOTVibl2= NEjkR2M4OiCq NWPvSXAxcW6mdXPld{BkgXSxdH;4bYNqfHliaX6gZUBkd26lZX70doF1cW:wLXTldIVv\GWwdDDtZY5v\XMEoB?= MkHXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5OUC5NFcoRjJ3N{mwPVA4RC:jPh?=
OCI-LY7 MoXtR4VtdCCYaXHibYxqfHliQYPzZZk> MVWyMlUuOTVibl2= MV23NkBp NGXvOWdqdmS3Y3XzJIN6fG:2b4jpZ4l1gSCrbjDhJINwdmOnboTyZZRqd25vZHXw[Y5l\W62IH3hco5mesLi NH3vR5Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe5NFkxPyd-MkW3PVA6ODd:L3G+
Farage M4TmTWNmdGxiVnnhZoltcXS7IFHzd4F6 MV:yMlUuOTVibl2= NY\iVlFQPzJiaB?= M{TCZolv\HWlZYOgZ5l1d3SxeHnjbZR6KGmwIHGgZ49v[2WwdILheIlwdi2mZYDlcoRmdnRibXHucoVzyqB? MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd7MEmwO{c,OjV5OUC5NFc9N2F-
LY7/EBV MYrD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MonFNk42NTF3IH7N NGXCc404OiCq NELidZVqdmS3Y3XzJIN6fG:2b4jpZ4l1gSCrbjDhJINwdmOnboTyZZRqd25vZHXw[Y5l\W62IH3hco5mesLi M1P0WlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{mwPVA4Lz5{NUe5NFkxPzxxYU6=
U2932/EBV MlH4R4VtdCCYaXHibYxqfHliQYPzZZk> NWHCcHZEOi53LUG1JI5O NHv4fnU4OiCq NXLPUYdocW6mdXPld{BkgXSxdH;4bYNqfHliaX6gZUBkd26lZX70doF1cW:wLXTldIVv\GWwdDDtZY5v\XMEoB?= MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd7MEmwO{c,OjV5OUC5NFc9N2F-
HCT116 Mne4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX[1MVUxODBibl2= NG[0RY0zPCCq NFq4T4NFVVOR M3PNOIlv\HWlZYOgZ4VtdCCmZXH0bEBqdiCjIHPvcoNmdnS{YYTpc44u\GWyZX7k[Y51KG2jbn7ldi=> MleyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2OUK1NVUoRjJ3NEmyOVE2RC:jPh?=
ACH-2 M1\ic2Z2dmO2aX;uJGF{e2G7 NXL6ZmJLOS17IH7N MlH0NlQhcA>? MY\pcoR2[2W|IFjJWk0yKEWwdjDlfJBz\XO|aX;u M2rIclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MUS5OFY4Lz5{NUG0PVQ3PzxxYU6=
MCF-10A M2Cw[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnyZnhEUUN3ME2wMlE4yrFyLkCxJI5O M2jQOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUW0PFU3Lz5{NEm1OFg2PjxxYU6=
MCF-7 NEDEXJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTFwMUFCtVAvOjBibl2= NYHKXFhjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5OVQ5PTZpPkK0PVU1QDV4PD;hQi=>
SK-BR-3 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTFwMEFCtVAvOzVibl2= MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3NEi1Okc,OjR7NUS4OVY9N2F-
MDA-MB-231 M4LDXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7XTWM2OD1yLk[4xtExNjF2IH7N NIfGTZI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1OFg2Pid-MkS5OVQ5PTZ:L3G+
PC3 MojsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4eyPGlEPTB;MT62OeKyOC5|NTDuUS=> MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3NEi1Okc,OjR7NUS4OVY9N2F-
HCT116 MnzzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\qd5NpUUN3ME2xMlAxyrFyLkCwJI5O MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3NEi1Okc,OjR7NUS4OVY9N2F-
HCT116-p21-/- NHfGO5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7aRZRKSzVyPUGuNlbDuTBwM{egcm0> Mo\PQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
S1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTdwNkhCtVAvOjlibl2= MlO0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
SW620 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nOR2lEPTB;MD65N:KyOC5{OTDuUS=> M4XxOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUW0PFU3Lz5{NEm1OFg2PjxxYU6=
LOX-IMVI MlfmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;abohZUUN3ME2wMlg4yrFyLkCzJI5O MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3NEi1Okc,OjR7NUS4OVY9N2F-
UACC-62 NYT3RolbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTBwNUdCtVAvOTZibl2= MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3NEi1Okc,OjR7NUS4OVY9N2F-
MDA-MB-435 NYLTbJRwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfXTWM2OD1yLkmwxtExNjB4IH7N NF;Sd4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1OFg2Pid-MkS5OVQ5PTZ:L3G+
SF-295 MoG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTBwOElCtVAvOTVibl2= NIi1fVM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1OFg2Pid-MkS5OVQ5PTZ:L3G+
A549 Ml\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XnNmlEPTB;MT6yOuKyOC5{NDDuUS=> NX\2dZU4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5OVQ5PTZpPkK0PVU1QDV4PD;hQi=>
H460 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjEd204UUN3ME2yMlU5yrFyLkiwJI5O MmHZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
EKVX NEjC[FFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2W3[2lEPTB;MT6zN:KyOC5|NDDuUS=> NH7WZ3Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1OFg2Pid-MkS5OVQ5PTZ:L3G+
H146 Mnv3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfzTWM2OD1yLkKyxtExNjB5IH7N NYnuXXpMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5OVQ5PTZpPkK0PVU1QDV4PD;hQi=>
H526 M13RTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M372emlEPTB;MD6xOeKyOC5yMzDuUS=> M3LNelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUW0PFU3Lz5{NEm1OFg2PjxxYU6=
HuT-78 NHn1d5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jHXGlEPTB;MT63N:KyOC52NDDuUS=> NEPvTlk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1OFg2Pid-MkS5OVQ5PTZ:L3G+
HA NFjie21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmO4NE43OjVvMUDuUS=> NXGzVpNrPDhiaB?= NXL2SHl2cW6mdXPld{BiKHOrZ37p[olk[W62bImgd5Rzd26pZYKgbY5pcWKrdHnvckBw\iClZXzsJJBzd2yrZnXyZZRqd25iY3:teJJm[XSnZDD3bZRpKGKxcoTlfo9ucWJ? NFzsN|c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEe3NVUyOCd-MkS3O|E2OTB:L3G+
MS-275 MlPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\nNE43OjVvMUDuUS=> NVvNS2c6PDhiaB?= M1vY[4lv\HWlZYOgZUB{cWewaX\pZ4FvfGy7IIP0do9v\2W{IHnubIljcXSrb36gc4Yh[2WubDDwdo9tcW[ncnH0bY9vKGOxLYTy[YF1\WRid3n0bEBjd3K2ZYrvcYlj NEPFToM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEe3NVUyOCd-MkS3O|E2OTB:L3G+
CD4 T M3K0Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIW1ZYk1QCCq MmrnSWM2OD12LkZCtVEvOCCwTR?= M3vpV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{KyOFU1Lz5{NEeyNlQ2PDxxYU6=
CD4 T MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nyUVQ5KGh? NV;xdXo3S0N3ME2xNFfDuTF{NjDuUS=> NFPiR3A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEeyNlQ2PCd-MkS3NlI1PTR:L3G+
CD4+ T M4rSWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17M[2VEPTB;MzDuUS=> NHj6OJQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NES5OVExPSd-MkS0PVUyODV:L3G+
A549 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\1SYtUOTEkgKOxNFDDqG6P MVSyOE8{Pi92ODDo NWTmOok2cW6qaXLpeJMh[2WubDDndo94fGhiaX6gZo91cCClb37j[Y51emG2aX;uMUBidmRidHnt[U1l\XCnbnTlcpQhdWGwbnXy Ml;4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR2OEW3PVkoRjJ2NEi1O|k6RC:jPh?=
JJN3 MmKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnSxNlQwPDhiaB?= MXzFR|UxRDIkgJnuUVshPDkkgJno MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB|MEG1NEc,OjRyM{CxOVA9N2F-
OPM-2 MlXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LiblI1NzR6IHi= NUHPfJljTUN3MIO9NgKBkW6POzC0PQKBkWh? NIDycY49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NECzNFE2OCd-MkSwN|AyPTB:L3G+
RPMI-8226 M3rQbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEf0clEzPC92ODDo NX\OOnBKTUN3MIO9NU456oDLbl27JFQ56oDLaB?= NV\KUmc4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwN|AyPTBpPkK0NFMxOTVyPD;hQi=>
U266 NVSwbGQ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU[yOE81QCCq MmnlSWM2OHN;MUFihKlvVTtiNElihKlp NV60V3YxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwN|AyPTBpPkK0NFMxOTVyPD;hQi=>
CA46 M4C0OmFxd3C2b4Ppd{BCe3OjeR?= NG\SbW03KGh? MXTpcoR2[2W|IHLseY51KGGyb4D0c5Nqew>? M2DsWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OU[2NVY1Lz5{M{m2OlE3PDxxYU6=
DG75 NX7yOYFCSXCxcITvd4l{KEG|c3H5 MoTSOkBp NWnL[ppFcW6mdXPld{BvdyCjcH;weI9{cXN? MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4NkG2OEc,OjN7Nk[xOlQ9N2F-
Ramos NVO4W3lxSXCxcITvd4l{KEG|c3H5 M{fIR|YhcA>? Mm\VbY5lfWOnczDlfJRmdnOrdnWgZZBweHSxc3nz M4fUU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OU[2NVY1Lz5{M{m2OlE3PDxxYU6=
ST486 NH7W[YNCeG:ydH;zbZMhSXO|YYm= M1S3U|YhcA>? NXXyfmx1cW6mdXPld{BmgHSnboPpeoUh[XCxcITvd4l{ MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4NkG2OEc,OjN7Nk[xOlQ9N2F-
HuT78 MkPRRZBweHSxc3nzJGF{e2G7 MWmxM|ExNzFyMDDuUS=> Mm\EOFghcA>? Mm\kbY5lfWOnczDhdI9xfG:|aYOgZZQhOSCwTR?= MnnzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3M{K3N|IoRjJ|NUOyO|MzRC:jPh?=
DpVp35 MYPBdI9xfG:|aYOgRZN{[Xl? MnSyNU8yOC9zMECgcm0> MYO0PEBp NFHpZ2xqdmS3Y3XzJIJtfW62IHHwc5B1d3Orcx?= M4XXelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NUOyO|MzLz5{M{WzNlc{OjxxYU6=
DpVp50 NVj5TVJ{SXCxcITvd4l{KEG|c3H5 NXLp[3V7OS9zMD:xNFAhdk1? MUK0PEBp MV\pcoR2[2W|IHLseY51KGGyb4D0c5Nqew>? NWewSlN1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1N|I4OzJpPkKzOVMzPzN{PD;hQi=>
DpP75  MV3BdI9xfG:|aYOgRZN{[Xl? M{jydVEwOTBxMUCwJI5O Mmr2OFghcA>? MVnpcoR2[2W|IHLseY51KGGyb4D0c5Nqew>? MoLJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3M{K3N|IoRjJ|NUOyO|MzRC:jPh?=
SKOV-3 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\IS|HjiJN{MH7N MlnLO|IhcA>? MYTEUXNQ NVPYU3dZemWmdXPld{Bk\WyuII\pZYJqdGm2eTDhcI9v\SCjbnSgZ49u[mmwZXSge4l1cCClaYPwcIF1cW5? NYXCdYl4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwNVA{PDhpPkKzNFExOzR6PD;hQi=>
Brca1 WT MnWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzwRYdbOeLCk{Kwcm0> NV\6T3RkPzJiaB?= NGfqToRFVVOR MUDy[YR2[2W|IHPlcIwhfmmjYnnsbZR6KGGub37lJIFv\CClb33ibY5m\CC5aYToJINqe3CuYYTpci=> MnXSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyMUCzOFgoRjJ|MEGwN|Q5RC:jPh?=
Brca1 Null MlzSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYWx5qCUOjCwTR?= MV23NkBp NHrnd|ZFVVOR NFfuTpNz\WS3Y3XzJINmdGxidnnhZoltcXS7IHHsc45mKGGwZDDjc41jcW6nZDD3bZRpKGOrc4DsZZRqdg>? MmWyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyMUCzOFgoRjJ|MEGwN|Q5RC:jPh?=
OVCAR-8  NW\pbGN4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIj4RlQy6oDVMkDuUS=> M1ezfFczKGh? M{PCSmROW09? MlPydoVlfWOnczDj[YxtKH[rYXLpcIl1gSCjbH;u[UBidmRiY3;tZolv\WRid3n0bEBkcXOybHH0bY4> MoHTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyMUCzOFgoRjJ|MEGwN|Q5RC:jPh?=
NCI/ADR-RES M3r4NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fkfVHjiJN{MH7N NVTFWnB7PzJiaB?= MXfEUXNQ MkizdoVlfWOnczDj[YxtKH[rYXLpcIl1gSCjbH;u[UBidmRiY3;tZolv\WRid3n0bEBkcXOybHH0bY4> M1;lVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MEGwN|Q5Lz5{M{CxNFM1QDxxYU6=
HCT116 NG\FcoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHnOUBvVS13MDFOwG0> NWKyUmJwOjRiaB?= MkXiSG1UVw>? NHj5W4tqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJINwdmOnboTyZZRqd25vZHXw[Y5l\W62IH3hco5meg>? MlXOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ7MkS5OVgoRjJ{OUK0PVU5RC:jPh?=
RKO M4XxbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVO1JI5ONTVyIN88US=> MVGyOEBp MXvEUXNQ MYTpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHPvcoNmdnS{YYTpc44u\GWyZX7k[Y51KG2jbn7ldi=> NIDxT5k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkmyOFk2QCd-MkK5NlQ6PTh:L3G+
CO115 M2DSUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWG1JI5ONTVyIN88US=> MYSyOEBp MYLEUXNQ NYLZSGFZcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBkd26lZX70doF1cW:wLXTldIVv\GWwdDDtZY5v\XJ? NVnncWNsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK5NlQ6PThpPkKyPVI1QTV6PD;hQi=>
HFS NULBXpd5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnGVHU2KG6P M2fs[|I1NzR6L{eyJIg> NVz6UJlvcW6qaXLpeJMh[2WubDDndo94fGhidHnt[U1l\XCnbnTlcpRtgQ>? NEXiVow9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkGwOlI5Oid-MkKxNFYzQDJ:L3G+
LNCaP NGLrSVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXWb4Y2KG6P MnLoNlQwPDhxN{KgbC=> NX;NVYROcW6qaXLpeJMh[2WubDDndo94fGhidHnt[U1l\XCnbnTlcpRtgQ>? NUnGOXBCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxNFYzQDJpPkKyNVA3Ojh{PD;hQi=>
A549 MlHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13uPFUhdk1? NIfkSJYzPC92OD:3NkBp MYjpcohq[mm2czDj[YxtKGe{b4f0bEB1cW2nLXTldIVv\GWwdHz5 MlH1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzME[yPFIoRjJ{MUC2NlgzRC:jPh?=
697  NXf1WGRUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;hZ4NbUUN3MPMAjV3jiIl{LkZCpI5O Mm\lQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3M{iyNVYoRjJzNUO4NlE3RC:jPh?=
697-R NVfoU45zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlmzTWM2OOLCiU5ihKk5NjcEoH7NxsA> NUjDW4Q5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1N|gzOTZpPkKxOVM5OjF4PD;hQi=>
HUT78 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7OXZhKSzVyPUGgcm0> MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTF7OEW0OUc,OjFzOUi1OFU9N2F-
THJ-16T MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWn2eXZ[OSCwTR?= MVuyOEBp NVfqPXllcW6qaXLpeJMh[2WubDDndo94fGh? NYT1[lFFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4NVA2PjhpPkKwPFExPTZ6PD;hQi=>
HCT116 MVzGeY5kfGmxbjDBd5NigQ>? MVOyNEBvVQ>? M1X6cFghcA>? MkXlcY9lfWyjdHXzJJRz[W6|Y4LpdJQhdGW4ZXzzJIZweiCqdX7kdoVleyCxZjDn[Y5meyCrbjDlbZRp\XJiZHny[YN1cW:w MkDDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB5M{m0OVQoRjJyN{O5OFU1RC:jPh?=
B104  MnjPSpVv[3Srb36gRZN{[Xl? M2PHcVIhdk1? M4LwVVI1NzR6L{eyJIg> NXXoenRQcW6lcnXhd4V{KHSqZTDzeZJn[WOnIHX4dJJme3Orb36gc4YhS0R{MNMg M{\pSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNki2OVA2Lz5{ME[4OlUxPTxxYU6=
HL-60  NGTxR2NEgXSxdH;4bYNqfHliQYPzZZk> MoPoNU02ODBibl2= NGC5bGQzPCCq NEHETJVqdmS3Y3XzJIN6fG:2b4jpZ4l1gSCrbjDhJINwdmOnboTyZZRqd25vZHXw[Y5l\W62IH3hco5mesLi M1rhdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNkK0NVY{Lz5{ME[yOFE3OzxxYU6=
HP100 NFH5Vo1EgXSxdH;4bYNqfHliQYPzZZk> NFjkfVcyNTVyMDDuUS=> MVOyOEBp MojibY5lfWOnczDjfZRwfG:6aXPpeJkhcW5iYTDjc45k\W62cnH0bY9vNWSncHXu[IVvfCCvYX7u[ZLDqA>? MmPGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB4MkSxOlMoRjJyNkK0NVY{RC:jPh?=
HL-60  NF6w[mpHfW6ldHnvckBCe3OjeR?= NYfhVodHOTBibl2= NGL4S5o1NzZxMU[gbC=> M1Pm[4lv\HWlZYOgeIhmKGenbnXyZZRqd25ib3[gbJllem:pZX6gdIVzd3irZHWg[pJwdSB2aB?= NXHCUo5GRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC2NlQyPjNpPkKwOlI1OTZ|PD;hQi=>
HP100 NULiPIFUTnWwY4Tpc44hSXO|YYm= NG\PfoMyOCCwTR?= NXvQZ4VjPC94L{G2JIg> NGrrZnJqdmS3Y3XzJJRp\SCpZX7ldoF1cW:wIH;mJIh6\HKxZ3XuJJBmem:6aXTlJIZzd21iNHi= M4\MPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNkK0NVY{Lz5{ME[yOFE3OzxxYU6=
HL-60  MVLGeY5kfGmxbjDBd5NigQ>? MXWxNE02ODBibl2= NGOzN|A1KGh? NE\tU4Jl\WO{ZXHz[ZMhfGinIHjpd5RwdmViZHXhZ4V1gWyjc3WgLGhFSUNrIHHjeIl3cXS7wrC= NVLuVpl1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC2NlQyPjNpPkKwOlI1OTZ|PD;hQi=>
HP100 M{jrNmZ2dmO2aX;uJGF{e2G7 NUfh[ZEzOTBvNUCwJI5O MW[0JIg> NXy5dXY3\GWlcnXhd4V{KHSqZTDobZN1d26nIHTlZYNmfHmuYYPlJEhJTEGFKTDhZ5Rqfmm2edMg NV7YXZpyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC2NlQyPjNpPkKwOlI1OTZ|PD;hQi=>
11z NX3ncY15U2mwYYPlJGF{e2G7 M1PPZlMuOTByIH7N M3zIWJJm\HWlZYOgTGRCSyCnbor5cYF1cWNiYXP0bZZqfHliKFnDOVDDqD1iNj61JOKyKDBwNjDucY9tN0xr NYr0[YVHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC2NFUyPDRpPkKwOlA2OTR2PD;hQi=>
SKOV-3 M1iwfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXleXM1NzhxMU[gcm0> MVG0PEBp MWDpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHPvcoNmdnS{YYTpc44u\GWyZX7k[Y51KG2jbn7ldi=> MoLKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB2MES1OlQoRjJyNEC0OVY1RC:jPh?=
OVCAR-3 MlzzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlryOE85NzF4IH7N MVO0PEBp NFL0VWdqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJINwdmOnboTyZZRqd25vZHXw[Y5l\W62IH3hco5meg>? M3jJN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNEC0OVY1Lz5{MESwOFU3PDxxYU6=
HBL-2 MlzxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jxPVIuOTBibl2= NILte4gzPCCq NX;rXolqUUN3ME20MlMhdk1? Mn6wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjByNkiwPFAoRjJyME[4NFgxRC:jPh?=
Jeko-1 MmiwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUeyMVUxKG6P M{nSdlI1KGh? Ml;QTWM2OD1zMTDuUS=> NUPVTWJTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCwOlgxQDBpPkKwNFY5ODhyPD;hQi=>
Granta-519 NXPCVIt[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLXV3o3PS12MDDuUS=> NYLpTlJxOjRiaB?= MYXJR|UxRTV6LkWgcm0> NFjoVI49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEC2PFA5OCd-MkCwOlgxQDB:L3G+
L1236 NU\IUlByS3m2b4TvfIlkcXS7IFHzd4F6 NV3Ke4pyOSCwTT2xNFAh|ryP NYriSVJzPDhiaB?= NVixbGJuTUN3ME2wMlA4KM7:TR?= M{nubVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkOzOFcxLz5zOUKzN|Q4ODxxYU6=
L428 MWfDfZRwfG:6aXPpeJkhSXO|YYm= NUPJPXZTOSCwTT2xNFAh|ryP MlWzOFghcA>? NXrwO3RjTUN3ME2wMlQ{KM7:TR?= NXvtO|J1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyN|M1PzBpPkG5NlM{PDdyPD;hQi=>
KM-H2 MWXDfZRwfG:6aXPpeJkhSXO|YYm= M4DRTVEhdk1vMUCwJO69VQ>? NF2ySmQ1QCCq MXrFR|UxRTBwNUig{txO M3;tUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkOzOFcxLz5zOUKzN|Q4ODxxYU6=
L540Cy M4O5XGN6fG:2b4jpZ4l1gSCDc4PhfS=> MXSxJI5ONTFyMDFOwG0> M{XJcFQ5KGh? M3\QVGVEPTB;MD6xOkDPxE1? M{m0OFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkOzOFcxLz5zOUKzN|Q4ODxxYU6=
G401 M1XiNWZ2dmO2aX;uJGF{e2G7 MnHzNVAhdk1? M3zoPFI1NzR6L{eyJIg> M3n1eGROW09? NH7ac2tqdmO{ZXHz[ZMhS0SNTkHDJIV5eHKnc4Ppc44> MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ{MUW4Okc,OTl{MkG1PFY9N2F-
STM91-01 NVTXZms4TnWwY4Tpc44hSXO|YYm= M3;ITFExKG6P M4jldlI1NzR6L{eyJIg> NXLuTXd2TE2VTx?= Mlj1bY5kemWjc3XzJGNFU05zQzDlfJBz\XO|aX;u NWXMU3lTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyNlE2QDZpPkG5NlIyPTh4PD;hQi=>
SJSC  NIq0eJVHfW6ldHnvckBCe3OjeR?= M3:3RVExKG6P NYXWTWtGOjRxNEivO|IhcA>? M1K3VGROW09? NH3YPWxqdmO{ZXHz[ZMhS0SNTkHDJIV5eHKnc4Ppc44> NXO5O|lGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyNlE2QDZpPkG5NlIyPTh4PD;hQi=>
BT16  NVP3Z5R[TnWwY4Tpc44hSXO|YYm= M2DuXVExKG6P MVGyOE81QC95MjDo NFj0cYVFVVOR M1;EWYlv[3KnYYPld{BETEuQMVOg[ZhxemW|c3nvci=> NX;MR5drRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyNlE2QDZpPkG5NlIyPTh4PD;hQi=>
NCI-H1299 MmrnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPMdJF[UUN3ME20MlbDuTBwMjDu[{9udA>? MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTF5OUi5NEc,OTlzN{m4PVA9N2F-
NCI-2882 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTFwNtMxNE4xPCCwZz;tcC=> M3WwZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MUe5PFkxLz5zOUG3PVg6ODxxYU6=
HCC95 MnjsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3HVmhKSzVyPUKuOeKyOC5yNTDu[{9udA>? MmXkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlzN{m4PVAoRjF7MUe5PFkxRC:jPh?=
NCI-H23 MoT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUi0RpczUUN3ME2yMlnDuTBwMjDu[{9udA>? M33yTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MUe5PFkxLz5zOUG3PVg6ODxxYU6=
NCI-H157 M17zXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTjdmxJUUN3ME2xMlbDuTBwMEKgcocwdWx? MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTF5OUi5NEc,OTlzN{m4PVA9N2F-
NCI-H460 MmDZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDWeHlKSzVyPUKuNeKyOC5yNzDu[{9udA>? NFTNdnE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUG3PVg6OCd-MUmxO|k5QTB:L3G+
NCI-H1975 Mn7jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjVdFJvUUN3ME2xMlPDuTBwMESgcocwdWx? MkXjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlzN{m4PVAoRjF7MUe5PFkxRC:jPh?=
NCI-H820 MlzPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LSb2lEPTB;Mj60xtExNjFibnevcYw> NFTHWGs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUG3PVg6OCd-MUmxO|k5QTB:L3G+
NCI-H1650 NXTvTIxpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3Wxc2lEPTB;ND65xtExNjNibnevcYw> NGr5bFg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUG3PVg6OCd-MUmxO|k5QTB:L3G+
DTC1 NIDLToNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXUTWM2OD1yLkWxJI5O MlnkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh3Nk[yOFYoRjF6NU[2NlQ3RC:jPh?=
KAO NEHlb3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\3TGlEPTB;MD65NUBvVQ>? NFGzdoc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEW2OlI1Pid-MUi1OlYzPDZ:L3G+
SU-CCS-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nk[2lEPTB;MD64PUBvVQ>? MnrOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh3Nk[yOFYoRjF6NU[2NlQ3RC:jPh?=
SYO-1 NIf3PZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3H2dWlEPTB;MD62O{BvVQ>? M2\3UlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NU[2NlQ3Lz5zOEW2OlI1PjxxYU6=
FUJI MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4WzdWlEPTB;MT6zNUBvVQ>? MmjwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh3Nk[yOFYoRjF6NU[2NlQ3RC:jPh?=
SKNMC NXnRdpRFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTFwMUegcm0> M2fMTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NU[2NlQ3Lz5zOEW2OlI1PjxxYU6=
402-91 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnSyTWM2OD1zLkK2JI5O NVzLUHhwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1OlYzPDZpPkG4OVY3OjR4PD;hQi=>
1765-92 MnvCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3LSoN[UUN3ME2xMlc4KG6P NIPlblM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEW2OlI1Pid-MUi1OlYzPDZ:L3G+
JN-DSRCT-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XkeGlEPTB;MT6yOUBvVQ>? NX\qXFBTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1OlYzPDZpPkG4OVY3OjR4PD;hQi=>
NMS-2PC MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvFfnpKSzVyPUCuPFEhdk1? MliyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh3Nk[yOFYoRjF6NU[2NlQ3RC:jPh?=
HL60 NEPvO4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTFwOE[gcm0> MmmyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh3Nk[yOFYoRjF6NU[2NlQ3RC:jPh?=
A549 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LzPWlEPTB;Mz6yOEBvVQ>? NILtU3c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEW2OlI1Pid-MUi1OlYzPDZ:L3G+
SW480 M1m1OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rScGlEPTB;Mj62PUBvVQ>? NGf4Zo09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEW2OlI1Pid-MUi1OlYzPDZ:L3G+
MCF7 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPjfJVKSzVyPUOuOVUhdk1? MorkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh3Nk[yOFYoRjF6NU[2NlQ3RC:jPh?=
PC-3 NUnTeoloT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfmNnNKSzVyPUKuOVEhdk1? NIj4flc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEW2OlI1Pid-MUi1OlYzPDZ:L3G+
MMRU M37RO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnpTWM2OD1{LkW3JI5O NUXiXGNzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1OlYzPDZpPkG4OVY3OjR4PD;hQi=>
Hs68 NV3XTIlOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfDTWM2OD1-MUCgcm0> MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDV4NkK0Okc,OTh3Nk[yOFY9N2F-
hMSC-001F NVqyU2N4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHJbotKSzVyPU6xNEBvVQ>? MoXJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh3Nk[yOFYoRjF6NU[2NlQ3RC:jPh?=
mammalian cells NVrNS4xETnWwY4Tpc44h[XO|YYm= NXfwTpQxUW6qaXLpeIlwdiCxZjDIbZN1d26nIHTlZYNmfHmuYYPlJFQhcW5ibXHtcYFtcWGwIHPlcIx{NCCLQ{WwJF0hOC53MTFOwG0v MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPDV6NEmzNkc,OTR3OES5N|I9N2F-
mammalian cells NWr1NmJSTnWwY4Tpc44h[XO|YYm= M3O0dWlvcGmkaYTpc44hd2ZiSHnzeI9v\SCmZXHj[ZR6dGG|ZTCxJIlv\HWlZXSgZYNmfHmuYYTl[EBpcXO2b37lJIlvKG2jbX3hcIlidiClZXzsd{4tKEWFNUCgQUA{PiEQvF2u NYSzVHZXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUS1PFQ6OzJpPkG0OVg1QTN{PD;hQi=>
MCF7 MUDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1LFWmdzd3e2aDDpcohq[mm2aX;uJI9nKE2FRkegZ4VtdHNuIFnDOVAhRSByLkCwNFc2KM7:TT6= MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzl3OEO0Nkc,OTd7NUizOFI9N2F-
A498 MU\DfZRwfG:6aXPpeJkh[XO|YYm= NF7z[|g3KGSjeYO= M37OXWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE1QThiY3XscJMh[W[2ZYKgOkBl[Xm|IHL5JG1VXCCjc4PhfUwhXEeLIE2gNE4xOjhizszNMi=> MnH5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkexOFYoRjJzOU[3NVQ3RC:jPh?=
COLO205 M3\COGN6fG:2b4jpZ4l1gSCjc4PhfS=> MkDhOkBl[Xm| NFqxc4pEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBEV0yRMkC1JINmdGy|IHHmeIVzKDZiZHH5d{BjgSCPVGSgZZN{[XluIGTHTUA:KDBwMEOxJO69VS5? MkLtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkexOFYoRjJzOU[3NVQ3RC:jPh?=
U251 NXTHTIhTS3m2b4TvfIlkcXS7IHHzd4F6 M{Pud|Yh\GG7cx?= M4TJc2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHUzPTFiY3XscJMh[W[2ZYKgOkBl[Xm|IHL5JG1VXCCjc4PhfUwhXEeLIE2gNE4xOzFizszNMi=> M3PXdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
RXF393 MnrDR5l1d3SxeHnjbZR6KGG|c3H5 M2TBXlYh\GG7cx?= MVvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDSXGY{QTNiY3XscJMh[W[2ZYKgOkBl[Xm|IHL5JG1VXCCjc4PhfUwhXEeLIE2gNE4xPjJizszNMi=> M3OyNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
MDA-MB-468 NULZV29oS3m2b4TvfIlkcXS7IHHzd4F6 NYfIU2pvPiCmYYnz MUnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvNE[4JINmdGy|IHHmeIVzKDZiZHH5d{BjgSCPVGSgZZN{[XluIGTHTUA:KDBwMEmg{txONg>? MoX4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkexOFYoRjJzOU[3NVQ3RC:jPh?=
COLO205 M3nNNWN6fG:2b4jpZ4l1gSCjc4PhfS=> MYq2JIRigXN? MYTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDU2xQOjB3IHPlcIx{KGGodHXyJFYh\GG7czDifUBOXFRiYYPzZZktKEyFNUCgQUAxNjB7MjFOwG0v MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl4N{G0Okc,OjF7NkexOFY9N2F-
UACC257 NV7iSZhwS3m2b4TvfIlkcXS7IHHzd4F6 MWC2JIRigXN? NGDscVBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBWSUOFMkW3JINmdGy|IHHmeIVzKDZiZHH5d{BjgSCPVGSgZZN{[XluIGTHTUA:KDBwMEm1JO69VS5? NUjDUGNZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlcyPDZpPkKxPVY4OTR4PD;hQi=>
U251 M4LTZmN6fG:2b4jpZ4l1gSCjc4PhfS=> NGm4bHo3KGSjeYO= MlPPR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWVI2OSClZXzsd{Bi\nSncjC2JIRigXNiYomgUXRVKGG|c3H5MEBNSzVyIE2gNE4yOyEQvF2u Ml\iQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkexOFYoRjJzOU[3NVQ3RC:jPh?=
A498 NITjfYdEgXSxdH;4bYNqfHliYYPzZZk> MVG2JIRigXN? NH\NVXFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPDl6IHPlcIx{KGGodHXyJFYh\GG7czDifUBOXFRiYYPzZZktKEyFNUCgQUAxNjJizszNMi=> MmHwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkexOFYoRjJzOU[3NVQ3RC:jPh?=
NCI-H322M NEPVSZlEgXSxdH;4bYNqfHliYYPzZZk> M1m1W|Yh\GG7cx?= NWXJXnd6S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVkOLLVizNlJOKGOnbHzzJIFnfGW{IE[g[IF6eyCkeTDNWHQh[XO|YYmsJHRIUSB;IECuNlMh|ryPLh?= MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl4N{G0Okc,OjF7NkexOFY9N2F-
SF295 NIr0dYFEgXSxdH;4bYNqfHliYYPzZZk> NVrGZW1rPiCmYYnz NGPucWFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUTjJ7NTDj[YxteyCjZoTldkA3KGSjeYOgZpkhVVSWIHHzd4F6NCCWR1mgQUAxNjJ3IN88UU4> MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl4N{G0Okc,OjF7NkexOFY9N2F-
RXF393 NFvu[VNEgXSxdH;4bYNqfHliYYPzZZk> NGC3WWQ3KGSjeYO= MlnMR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVnhHOzl|IHPlcIx{KGGodHXyJFYh\GG7czDifUBOXFRiYYPzZZktKEyFNUCgQUAxNjNizszNMi=> MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl4N{G0Okc,OjF7NkexOFY9N2F-
NCI60 NHPGR|VEgXSxdH;4bYNqfHliYYPzZZk> MnfoOkBl[Xm| M1PZUWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5EUTZyIHPlcIx{KGGodHXyJFYh\GG7czDifUBOXFRiYYPzZZktKFSJSTC9JFAvOzNizszNMi=> MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl4N{G0Okc,OjF7NkexOFY9N2F-
SN12C NUDrbYxoS3m2b4TvfIlkcXS7IHHzd4F6 NWf1bWhOPiCmYYnz MoT0R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV24yOkNiY3XscJMh[W[2ZYKgOkBl[Xm|IHL5JG1VXCCjc4PhfUwhXEeLIE2gNE4{PCEQvF2u MoTsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkexOFYoRjJzOU[3NVQ3RC:jPh?=
MDA-MB-231 M2TpR2N6fG:2b4jpZ4l1gSCjc4PhfS=> NF36Z5I3KGSjeYO= NF3tVpVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIFnfGW{IE[g[IF6eyCkeTDNWHQh[XO|YYmsJHRIUSB;IECuN|Uh|ryPLh?= M3HvZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
ACHN NXTiOINES3m2b4TvfIlkcXS7IHHzd4F6 MXm2JIRigXN? MlXXR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRWNJViClZXzsd{Bi\nSncjC2JIRigXNiYomgUXRVKGG|c3H5MEBVT0liPTCwMlc{KM7:TT6= NUO4PW1lRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlcyPDZpPkKxPVY4OTR4PD;hQi=>
SN12C MVfDfZRwfG:6aXPpeJkh[XO|YYm= NIXaXGQ3KGSjeYO= MUfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTUlEzSyClZXzsd{Bi\nSncjC2JIRigXNiYomgUXRVKGG|c3H5MEBNSzVyIE2gNU42KM7:TT6= NWXvXGZCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlcyPDZpPkKxPVY4OTR4PD;hQi=>
UO31 MVLDfZRwfG:6aXPpeJkh[XO|YYm= NWCzUFZrPiCmYYnz Mm\vR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWW8{OSClZXzsd{Bi\nSncjC2JIRigXNiYomgUXRVKGG|c3H5MEBVT0liPTCxMlU2KM7:TT6= NEW2U5E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm2O|E1Pid-MkG5OlcyPDZ:L3G+
Caki1 M2jlW2N6fG:2b4jpZ4l1gSCjc4PhfS=> M3rz[FYh\GG7cx?= NF7JOplEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBE[WurMTDj[YxteyCjZoTldkA3KGSjeYOgZpkhVVSWIHHzd4F6NCCWR1mgQUAyNjh7IN88UU4> NVHkZ5pORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlcyPDZpPkKxPVY4OTR4PD;hQi=>
NCI60 NYexU3VtS3m2b4TvfIlkcXS7IHHzd4F6 MWW2JIRigXN? NIHzc5BEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBPS0l4MDDj[YxteyCjZoTldkA3KGSjeYOgZpkhVVSWIHHzd4F6NCCOQ{WwJF0hOy53IN88UU4> M3HURlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
MDA-MB-231 MnXPR5l1d3SxeHnjbZR6KGG|c3H5 M4P2VFYh\GG7cx?= MWLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDZiZHH5d{BjgSCPVGSgZZN{[XluIFzDOVAhRSB2LkC4JO69VS5? MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl4N{G0Okc,OjF7NkexOFY9N2F-
MDA-MB-468 MYHDfZRwfG:6aXPpeJkh[XO|YYm= M1fCTlYh\GG7cx?= MnfPR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUS2PEBk\WyuczDh[pRmeiB4IHThfZMh[nliTWTUJIF{e2G7LDDMR|UxKD1iND6xOEDPxE1w NIi2cVc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm2O|E1Pid-MkG5OlcyPDZ:L3G+
ACHN MnfhR5l1d3SxeHnjbZR6KGG|c3H5 M2fVW|Yh\GG7cx?= NXnxXXVJS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSUOKTjDj[YxteyCjZoTldkA3KGSjeYOgZpkhVVSWIHHzd4F6NCCOQ{WwJF0hPS5|NzFOwG0v M1vQVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
UACC257 NV7GOGRrS3m2b4TvfIlkcXS7IHHzd4F6 M1j3VlYh\GG7cx?= MlzKR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWWFESzJ3NzDj[YxteyCjZoTldkA3KGSjeYOgZpkhVVSWIHHzd4F6NCCOQ{WwJF0hPS52NjFOwG0v MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl4N{G0Okc,OjF7NkexOFY9N2F-
NCI-H322M NWnNcHR1S3m2b4TvfIlkcXS7IHHzd4F6 NYTwcXZMPiCmYYnz NUX5WphwS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVkOLLVizNlJOKGOnbHzzJIFnfGW{IE[g[IF6eyCkeTDNWHQh[XO|YYmsJGxEPTBiPTC5MlAzKM7:TT6= M2HS[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
SF295 MUTDfZRwfG:6aXPpeJkh[XO|YYm= MmTrOkBl[Xm| M3e5d2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNHOjl3IHPlcIx{KGGodHXyJFYh\GG7czDifUBOXFRiYYPzZZktKEyFNUCgQUAyOC5{IN88UU4> NHT1TIY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm2O|E1Pid-MkG5OlcyPDZ:L3G+
Caki1 NXO2eJI6S3m2b4TvfIlkcXS7IHHzd4F6 MXq2JIRigXN? Mor5R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR4FscTFiY3XscJMh[W[2ZYKgOkBl[Xm|IHL5JG1VXCCjc4PhfUwhVEN3MDC9JFIxNjlizszNMi=> M1f4fFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
NCI-H23 MmD6RY51cXS3bX;yJIF{e2G7 MY[xMlYhfG9iMj60JI1oN2up NEi4OHF2eCC2bzC1JIRigXN? MlfuRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWgzOyClZXzsd{BqdXCuYX70[YQhcW62cnHw[ZJqfG:wZXHscJkhcW5ibX;1d4Uh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB1fW2xcjDj[YxtKGe{b4f0bEBifCBzLk[geI8hOi52IH3nM4toNCCrcDDh[I1qdmm|dHXy[YQhd25iZHH5JFEhfG9iNDDt[YF{fXKnZDDvckBl[XliNTDifUBpd2yub4eg[olj\XJiYYPzZZk> MmjqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkexOFYoRjJzOU[3NVQ3RC:jPh?=
NCI-H522 M2jPcGFvfGm2dX3vdkBie3OjeR?= NEThcGgyNjZidH:gNk41KG2pL3vn NIPtO5h2eCC2bzC1JIRigXN? M13VOGFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF7DTU1JPTJ{IHPlcIx{KGmvcHzhcpRm\CCrboTyZZBmemm2b37lZYxtgSCrbjDtc5V{\SCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHS3bX;yJINmdGxiZ4Lve5RpKGG2IEGuOkB1dyB{LkSgcYcwc2duIHnwJIFldWmwaYP0[ZJm\CCxbjDkZZkhOSC2bzC0JI1m[XO3cnXkJI9vKGSjeTC1JIJ6KGixbHzve{BncWKncjDhd5NigQ>? M4mw[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
OVCAR5 M2rJfGFvfGm2dX3vdkBie3OjeR?= NV:4XGpyOS54IITvJFIvPCCvZz;r[y=> Mon4eZAhfG9iNTDkZZl{ M3rIR2FvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF;WR2FTPSClZXzsd{BqdXCuYX70[YQhcW62cnHw[ZJqfG:wZXHscJkhcW5ibX;1d4Uh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB1fW2xcjDj[YxtKGe{b4f0bEBifCBzLk[geI8hOi52IH3nM4toNCCrcDDh[I1qdmm|dHXy[YQhd25iZHH5JFEhfG9iNDDt[YF{fXKnZDDvckBl[XliNTDifUBpd2yub4eg[olj\XJiYYPzZZk> MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl4N{G0Okc,OjF7NkexOFY9N2F-
SW620 NHzEe|lCdnSrdIXtc5Ih[XO|YYm= NG\6[WsyNjZidH:gNk41KG2pL3vn MkfheZAhfG9iNTDkZZl{ MYjBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDoeY1idiCVV{[yNEBk\WyuczDpcZBt[W62ZXSgbY51emGyZYLpeI9v\WGubImgbY4hdW:3c3WgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD0eY1weiClZXzsJIdzd3e2aDDheEAyNjZidH:gNk41KG2pL3vnMEBqeCCjZH3pcol{fGW{ZXSgc44h\GG7IEGgeI8hPCCvZXHzeZJm\CCxbjDkZZkhPSCkeTDoc4xtd3diZnni[ZIh[XO|YYm= NH;wc2o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm2O|E1Pid-MkG5OlcyPDZ:L3G+
MDA-MB-435 NXrRPHRqSW62aYT1cY9zKGG|c3H5 MUGxMlYhfG9iMj60JI1oN2up MlvueZAhfG9iNTDkZZl{ MmXSRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTR|NTDj[YxteyCrbYDsZY51\WRiaX70doFx\XKrdH;u[YFtdHliaX6gcY92e2ViYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC2dX3vdkBk\WyuIHfyc5d1cCCjdDCxMlYhfG9iMj60JI1oN2upLDDpdEBi\G2rbnnzeIVz\WRib36g[IF6KDFidH:gOEBu\WG|dYLl[EBwdiCmYYmgOUBjgSCqb3zsc5ch\mmkZYKgZZN{[Xl? NGTvR2I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm2O|E1Pid-MkG5OlcyPDZ:L3G+
COLO205 MUHBcpRqfHWvb4KgZZN{[Xl? M{DuOVEvPiC2bzCyMlQhdWdxa3e= NYr3WmxyfXBidH:gOUBl[Xm| NY[xe2xoSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gR29NVzJyNTDj[YxteyCrbYDsZY51\WRiaX70doFx\XKrdH;u[YFtdHliaX6gcY92e2ViYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC2dX3vdkBk\WyuIHfyc5d1cCCjdDCxMlYhfG9iMj60JI1oN2upLDDpdEBi\G2rbnnzeIVz\WRib36g[IF6KDFidH:gOEBu\WG|dYLl[EBwdiCmYYmgOUBjgSCqb3zsc5ch\mmkZYKgZZN{[Xl? NHjZb3o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm2O|E1Pid-MkG5OlcyPDZ:L3G+
LOXIMVI MoHJRY51cXS3bX;yJIF{e2G7 NXHBbW1sOS54IITvJFIvPCCvZz;r[y=> NFHqcoh2eCC2bzC1JIRigXN? NGDmRW1CdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDMU3hKVV[LIHPlcIx{KGmvcHzhcpRm\CCrboTyZZBmemm2b37lZYxtgSCrbjDtc5V{\SCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHS3bX;yJINmdGxiZ4Lve5RpKGG2IEGuOkB1dyB{LkSgcYcwc2duIHnwJIFldWmwaYP0[ZJm\CCxbjDkZZkhOSC2bzC0JI1m[XO3cnXkJI9vKGSjeTC1JIJ6KGixbHzve{BncWKncjDhd5NigQ>? NXTrRo9{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlcyPDZpPkKxPVY4OTR4PD;hQi=>
UACC62 MluzRY51cXS3bX;yJIF{e2G7 NHfYRo4yNjZidH:gNk41KG2pL3vn NXWzfHI3fXBidH:gOUBl[Xm| NInUVWVCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDVRWNEPjJiY3XscJMhcW2ybHHueIVlKGmwdILhdIVzcXSxbnXhcIx6KGmwIH3veZNmKGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhfHWvb4KgZ4VtdCCpcn;3eIgh[XRiMT62JJRwKDJwNDDt[{9s\yxiaYCgZYRucW6rc4TldoVlKG:wIHThfUAyKHSxIESgcYVie3W{ZXSgc44h\GG7IEWgZpkhcG:ubH;3JIZq[mW{IHHzd4F6 NVvZdoQ2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlcyPDZpPkKxPVY4OTR4PD;hQi=>
MDA-MB-231 NHrMVYhCdnSrdIXtc5Ih[XO|YYm= M1;lc|EvPiC2bzCyMlQhdWdxa3e= MoXJeZAhfG9iNTDkZZl{ M1HVcWFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiaX3wcIFvfGWmIHnueJJieGW{aYTvcoVidGy7IHnuJI1wfXOnIHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidIXtc5Ih[2WubDDndo94fGhiYYSgNU43KHSxIEKuOEBu\y:tZzygbZAh[WSvaX7pd5RmemWmIH;uJIRigSBzIITvJFQhdWWjc4Xy[YQhd25iZHH5JFUh[nliaH;scI94KG[rYnXyJIF{e2G7 MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl4N{G0Okc,OjF7NkexOFY9N2F-
SF295 NH;GSm9CdnSrdIXtc5Ih[XO|YYm= MmW1NU43KHSxIEKuOEBu\y:tZx?= MVv1dEB1dyB3IHThfZM> NYjqT5RWSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gV2YzQTViY3XscJMhcW2ybHHueIVlKGmwdILhdIVzcXSxbnXhcIx6KGmwIH3veZNmKGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhfHWvb4KgZ4VtdCCpcn;3eIgh[XRiMT62JJRwKDJwNDDt[{9s\yxiaYCgZYRucW6rc4TldoVlKG:wIHThfUAyKHSxIESgcYVie3W{ZXSgc44h\GG7IEWgZpkhcG:ubH;3JIZq[mW{IHHzd4F6 MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl4N{G0Okc,OjF7NkexOFY9N2F-
U251 MlzRRY51cXS3bX;yJIF{e2G7 M2qxb|EvPiC2bzCyMlQhdWdxa3e= NYTtUGtnfXBidH:gOUBl[Xm| NITtbYhCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDVNlUyKGOnbHzzJIlueGyjboTl[EBqdnS{YYDldol1d26nYXzsfUBqdiCvb4Xz[UBie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJR2dW:{IHPlcIwh\3Kxd4ToJIF1KDFwNjD0c{AzNjRibXevb4ctKGmyIHHkcYlvcXO2ZYLl[EBwdiCmYYmgNUB1dyB2IH3lZZN2emWmIH;uJIRigSB3IHL5JIhwdGyxdzDmbYJmeiCjc4PhfS=> M{PQRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
OVRAC3 MYLBcpRqfHWvb4KgZZN{[Xl? NHvh[XYyNjZidH:gNk41KG2pL3vn MoTOeZAhfG9iNTDkZZl{ MoPqRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iT2\SRWM{KGOnbHzzJIlueGyjboTl[EBqdnS{YYDldol1d26nYXzsfUBqdiCvb4Xz[UBie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJR2dW:{IHPlcIwh\3Kxd4ToJIF1KDFwNjD0c{AzNjRibXevb4ctKGmyIHHkcYlvcXO2ZYLl[EBwdiCmYYmgNUB1dyB2IH3lZZN2emWmIH;uJIRigSB3IHL5JIhwdGyxdzDmbYJmeiCjc4PhfS=> NEftZWo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm2O|E1Pid-MkG5OlcyPDZ:L3G+
LLC MXzGeY5kfGmxbjDhd5NigQ>? NWfBcmluUW6qaXLpeIlwdiCxZjDISGFENW2nZHnheIVlKEiLRj2xZYxxcGFiYXP0bZZqfHliaX6gcY92e2ViTFzDJINmdGy|LDDJR|UxKD1iMjFOwG0v M3XCNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{C1OlEzLz5{MkOwOVYyOjxxYU6=
NCI-H522 MlPES5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEPzTpJIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEWyNkBk\WyuczDifUB{fWyob4Loc4RidWmwZTDCJINwdG:{aX3leJJq[yCvZYToc4QtKEeLNUCgQUAxNjByMUig{txONg>? NV3mbGtlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNVM3OzhpPkKzN|E{PjN6PD;hQi=>
LOXIMVI M2Hpbmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYXMO2szT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVE:[SV3WTUBk\WyuczDifUB{fWyob4Loc4RidWmwZTDCJINwdG:{aX3leJJq[yCvZYToc4QtKEeLNUCgQUAxNjByMkWg{txONg>? M4TmS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{GzOlM5Lz5{M{OxN|Y{QDxxYU6=
A549 NH7CZ25Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUDHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDBOVQ6KGOnbHzzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[2:ub4LpcYV1emmlIH3leIhw\CxiR1m1NEA:KDBwMECyOkDPxE1w NH;YNXA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OxN|Y{QCd-MkOzNVM3Ozh:L3G+
OVCAR5 MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVnHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDPWmNCWjViY3XscJMh[nlic4Xs[o9zcG:mYX3pcoUhSiClb3zvdolu\XS{aXOgcYV1cG:mLDDHTVUxKD1iMD6wNFI5KM7:TT6= MmjDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MUO2N|goRjJ|M{GzOlM5RC:jPh?=
MKN74 NHTIelhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUPHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDNT244PCClZXzsd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGOxbH;ybY1mfHKrYzDt[ZRpd2RuIFfJOVAhRSByLkCwN{DPxE1w NITUS3E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OxN|Y{QCd-MkOzNVM3Ozh:L3G+
NCI-H460 NX;aWI84T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2i2dmdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNE[wJINmdGy|IHL5JJN2dG[xcnjv[IFucW6nIFKgZ49td3KrbXX0dolkKG2ndHjv[EwhT0l3MDC9JFAvODB|IN88UU4> NYj3NIw2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNVM3OzhpPkKzN|E{PjN6PD;hQi=>
HCT116 NV2wb4ZWT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFLO[VBIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBJS1RzMU[gZ4VtdHNiYomgd5Vt\m:{aH;kZY1qdmViQjDjc4xwemmvZYTybYMhdWW2aH;kMEBIUTVyIE2gNE4xODNzIN88UU4> MlnUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MUO2N|goRjJ|M{GzOlM5RC:jPh?=
HCC2998 NVjh[mFqT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NH6yV2pIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBJS0N{OUm4JINmdGy|IHL5JJN2dG[xcnjv[IFucW6nIFKgZ49td3KrbXX0dolkKG2ndHjv[EwhT0l3MDC9JFAvODB|MTFOwG0v MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{[zPEc,OjN|MUO2N|g9N2F-
MKN1 NUe0N5g3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFfnNI1Iem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBOU05zIHPlcIx{KGK7IIP1cIZwemixZHHtbY5mKEJiY3;sc5JqdWW2cnnjJI1mfGixZDygS2k2OCB;IECuNFA{OiEQvF2u MlniQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MUO2N|goRjJ|M{GzOlM5RC:jPh?=
SKOV3 NE\tXXVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MW\Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDTT29XOyClZXzsd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGOxbH;ybY1mfHKrYzDt[ZRpd2RuIFfJOVAhRSByLkCwN|Mh|ryPLh?= Mlv6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MUO2N|goRjJ|M{GzOlM5RC:jPh?=
HT-29 NWf1c2FST3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVHtfW9{T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUFRvMkmgZ4VtdHNiYomgd5Vt\m:{aH;kZY1qdmViQjDjc4xwemmvZYTybYMhdWW2aH;kMEBIUTVyIE2gNE4xODN|IN88UU4> M3XXV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{GzOlM5Lz5{M{OxN|Y{QDxxYU6=
KM12 MXzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoHKS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gT20yOiClZXzsd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGOxbH;ybY1mfHKrYzDt[ZRpd2RuIFfJOVAhRSByLkCwN|Qh|ryPLh?= NX[2T3ZzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNVM3OzhpPkKzN|E{PjN6PD;hQi=>
DMS114 Mn3VS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{\afWdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGROWzFzNDDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHPvcI9zcW2ndILpZ{Bu\XSqb3SsJGdKPTBiPTCwMlAxOzZizszNMi=> MnX5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MUO2N|goRjJ|M{GzOlM5RC:jPh?=
SF539 M3fmZWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlvMS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gV2Y2OzliY3XscJMh[nlic4Xs[o9zcG:mYX3pcoUhSiClb3zvdolu\XS{aXOgcYV1cG:mLDDHTVUxKD1iMD6wNFM3KM7:TT6= MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{[zPEc,OjN|MUO2N|g9N2F-
U251 NFHDTmlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NY\wVIJ4T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hXTJ3MTDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHPvcI9zcW2ndILpZ{Bu\XSqb3SsJGdKPTBiPTCwMlAxOzlizszNMi=> MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{[zPEc,OjN|MUO2N|g9N2F-
SF295 M3PLUWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mn\LS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gV2YzQTViY3XscJMh[nlic4Xs[o9zcG:mYX3pcoUhSiClb3zvdolu\XS{aXOgcYV1cG:mLDDHTVUxKD1iMD6wNFQh|ryPLh?= NEjySVM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OxN|Y{QCd-MkOzNVM3Ozh:L3G+
MCF7 MmLDS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXP5WlFkT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVUOINzDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHPvcI9zcW2ndILpZ{Bu\XSqb3SsJGdKPTBiPTCwMlAxPDJizszNMi=> MlfHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MUO2N|goRjJ|M{GzOlM5RC:jPh?=
NCI-H23 MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4fXNGdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkOgZ4VtdHNiYomgd5Vt\m:{aH;kZY1qdmViQjDjc4xwemmvZYTybYMhdWW2aH;kMEBIUTVyIE2gNE4xODR4IN88UU4> NXnES|FTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNVM3OzhpPkKzN|E{PjN6PD;hQi=>
OVCAR3 MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Ml36S5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gU3ZESVJ|IHPlcIx{KGK7IIP1cIZwemixZHHtbY5mKEJiY3;sc5JqdWW2cnnjJI1mfGixZDygS2k2OCB;IECuNFA1PiEQvF2u MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{[zPEc,OjN|MUO2N|g9N2F-
MKN7 NXvmVFB{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUTHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDNT244KGOnbHzzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[2:ub4LpcYV1emmlIH3leIhw\CxiR1m1NEA:KDBwMEC0PUDPxE1w M2XmZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{GzOlM5Lz5{M{OxN|Y{QDxxYU6=
SF268 MULHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkHWS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gV2YzPjhiY3XscJMh[nlic4Xs[o9zcG:mYX3pcoUhSiClb3zvdolu\XS{aXOgcYV1cG:mLDDHTVUxKD1iMD6wNFQ6KM7:TT6= MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{[zPEc,OjN|MUO2N|g9N2F-
MDA-MB-231 NEDoW2NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlnnS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDifUB{fWyob4Loc4RidWmwZTDCJINwdG:{aX3leJJq[yCvZYToc4QtKEeLNUCgQUAxNjByNUWg{txONg>? MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{[zPEc,OjN|MUO2N|g9N2F-
OVCAR8 MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NG\N[HZIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBQXkODUkigZ4VtdHNiYomgd5Vt\m:{aH;kZY1qdmViQjDjc4xwemmvZYTybYMhdWW2aH;kMEBIUTVyIE2gNE4xODV3IN88UU4> M4\yOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{GzOlM5Lz5{M{OxN|Y{QDxxYU6=
DMS273 NXHwZlIxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGXwWoRIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBFVVN{N{OgZ4VtdHNiYomgd5Vt\m:{aH;kZY1qdmViQjDjc4xwemmvZYTybYMhdWW2aH;kMEBIUTVyIE2gNE4xODV6IN88UU4> Mn\WQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MUO2N|goRjJ|M{GzOlM5RC:jPh?=
DU145 M4PrNGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NF3n[mVIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBFXTF2NTDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHPvcI9zcW2ndILpZ{Bu\XSqb3SsJGdKPTBiPTCwMlAxPiEQvF2u NU[zSHZCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNVM3OzhpPkKzN|E{PjN6PD;hQi=>
RXF631L M{nC[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlHUS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gVnhHPjNzTDDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHPvcI9zcW2ndILpZ{Bu\XSqb3SsJGdKPTBiPTCwMlAxPjZizszNMi=> MnHtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MUO2N|goRjJ|M{GzOlM5RC:jPh?=
HBC4 NUT3OYVJT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3\zW2dzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGhDSzRiY3XscJMh[nlic4Xs[o9zcG:mYX3pcoUhSiClb3zvdolu\XS{aXOgcYV1cG:mLDDHTVUxKD1iMD6wNFY6KM7:TT6= MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{[zPEc,OjN|MUO2N|g9N2F-
SNB75 M4LJVGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWXHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDTUmI4PSClZXzsd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGOxbH;ybY1mfHKrYzDt[ZRpd2RuIFfJOVAhRSByLkCwO|Ih|ryPLh?= NYHwXphURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNVM3OzhpPkKzN|E{PjN6PD;hQi=>
BSY1 MnrzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVPHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDCV3kyKGOnbHzzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[2:ub4LpcYV1emmlIH3leIhw\CxiR1m1NEA:KDBwMEC4OUDPxE1w M3rE[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{GzOlM5Lz5{M{OxN|Y{QDxxYU6=
NCI-H226 NITVZ41Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXfHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDOR2kuUDJ{NjDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHPvcI9zcW2ndILpZ{Bu\XSqb3SsJGdKPTBiPTCwMlAxQDlizszNMi=> NEjOWVY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OxN|Y{QCd-MkOzNVM3Ozh:L3G+
SNB78 MnrNS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVLHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDTUmI4QCClZXzsd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGOxbH;ybY1mfHKrYzDt[ZRpd2RuIFfJOVAhRSByLkCwPVYh|ryPLh?= MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{[zPEc,OjN|MUO2N|g9N2F-
HBC5 MVjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVu4[2YzT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUEKFNTDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHPvcI9zcW2ndILpZ{Bu\XSqb3SsJGdKPTBiPTCwMlAyOyEQvF2u Mly4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MUO2N|goRjJ|M{GzOlM5RC:jPh?=
MKN45 NWjsVIxzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHHyVHlIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBOU052NTDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHPvcI9zcW2ndILpZ{Bu\XSqb3SsJGdKPTBiPTCwMlAyPCEQvF2u MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{[zPEc,OjN|MUO2N|g9N2F-
MKN28 MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXvUcmM4T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVUuQMkigZ4VtdHNiYomgd5Vt\m:{aH;kZY1qdmViQjDjc4xwemmvZYTybYMhdWW2aH;kMEBIUTVyIE2gNE4xOTdizszNMi=> M{TUNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{GzOlM5Lz5{M{OxN|Y{QDxxYU6=
PC3 NXjDfIVtT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NF\HbZNIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBRSzNiY3XscJMh[nlic4Xs[o9zcG:mYX3pcoUhSiClb3zvdolu\XS{aXOgcYV1cG:mLDDHTVUxKD1iMD6wNVgh|ryPLh?= M2[2cVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{GzOlM5Lz5{M{OxN|Y{QDxxYU6=
ACHN MmHlS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mme5S5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gRWNJViClZXzsd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGOxbH;ybY1mfHKrYzDt[ZRpd2RuIFfJOVAhRSByLkCyJO69VS5? NVHN[21iRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNVM3OzhpPkKzN|E{PjN6PD;hQi=>
OVCAR4 NXLLWYFQT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1KzPGdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG9XS0GUNDDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHPvcI9zcW2ndILpZ{Bu\XSqb3SsJGdKPTBiPTCwMlAzKM7:TT6= MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{[zPEc,OjN|MUO2N|g9N2F-
St-4 Mn7OS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVKzOGlbT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hW3RvNDDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHPvcI9zcW2ndILpZ{Bu\XSqb3SsJGdKPTBiPTCwMlAzOiEQvF2u NWX0[WdRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNVM3OzhpPkKzN|E{PjN6PD;hQi=>
HCT15 MkfYS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUPOTmppT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUEOWMUWgZ4VtdHNiYomgd5Vt\m:{aH;kZY1qdmViQjDjc4xwemmvZYTybYMhdWW2aH;kMEBIUTVyIE2gNE41PSEQvF2u NGTVVYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OxN|Y{QCd-MkOzNVM3Ozh:L3G+
CD4+ T NIH4[nhHfW6ldHnvckBie3OjeR?= NGrjN4k4KGSjeYO= NXHQNY9ZWmWjY4TpeoF1cW:wIH;mJIxifGWwdDDITXYyKE6OND2zMWx2[yCneIDy[ZN{cW:wIHnuJIh2dWGwIH7hbZZmKEOGNDugWEBk\WyuczD0doVifGWmIEeg[IF6eyCyb4P0MYlv\mWldHnvckBu\WG|dYLl[EBi\nSncjC0PEBpenNiYomgcJVucW6nc3PlcoNmKHCuYYTlJJJm[WSncjDhcoFtgXOrczygSWM2OCB;IECuNFA{KM7:TT6= MkWzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR2OUWxNFUoRjJ2NEm1NVA2RC:jPh?=
NCI-H522 MmfaR5l1d3SxeHnjbZR6KGG|c3H5 Ml7HR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUmNKNUh3MkKgZ4VtdHNiYomgV3JDKGG|c3H5MEBIUTVyIE2gNE4xODF6IN88UU4> MlL3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEm0PFYoRjJ2NUi5OFg3RC:jPh?=
LOXIMVI NWGwcIRZS3m2b4TvfIlkcXS7IHHzd4F6 NFfRPHVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBNV1iLTW\JJINmdGy|IHL5JHNTSiCjc4PhfUwhT0l3MDC9JFAvODB{NTFOwG0v MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
A549 M1rYXmN6fG:2b4jpZ4l1gSCjc4PhfS=> NVLxUIFsS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAxOjZizszNMi=> NXjCO|hnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
OVCAR5 M4jyTGN6fG:2b4jpZ4l1gSCjc4PhfS=> MWTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDPWmNCWjViY3XscJMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMD6wNFI5KM7:TT6= M{DRZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUi5OFg3Lz5{NEW4PVQ5PjxxYU6=
NCI-H460 MojBR5l1d3SxeHnjbZR6KGG|c3H5 Mo\5R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUmNKNUh2NkCgZ4VtdHNiYomgV3JDKGG|c3H5MEBIUTVyIE2gNE4xODNizszNMi=> MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
MKN74 M{D1PWN6fG:2b4jpZ4l1gSCjc4PhfS=> MnLMR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWtPPzRiY3XscJMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMD6wNFMh|ryPLh?= NHnEWGw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW4PVQ5Pid-MkS1PFk1QDZ:L3G+
HCC2998 MoXpR5l1d3SxeHnjbZR6KGG|c3H5 MlHOR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGNEOjl7ODDj[YxteyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAxOzFizszNMi=> MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
HCT116 NED0UJVEgXSxdH;4bYNqfHliYYPzZZk> MkT4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGNVOTF4IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFA{OSEQvF2u NVzMc483RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
MKN1 MXnDfZRwfG:6aXPpeJkh[XO|YYm= MUjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNT24yKGOnbHzzJIJ6KFOUQjDhd5NigSxiR1m1NEA:KDBwMECzNkDPxE1w MmrZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEm0PFYoRjJ2NUi5OFg3RC:jPh?=
HT-29 M1LXWGN6fG:2b4jpZ4l1gSCjc4PhfS=> NHj4Wo9EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJXC1{OTDj[YxteyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAxOzNizszNMi=> NXjQcXk{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
SKOV3 MmrYR5l1d3SxeHnjbZR6KGG|c3H5 M2[0VmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMV1Z|IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFA{OyEQvF2u MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
KM12 M3ntXWN6fG:2b4jpZ4l1gSCjc4PhfS=> M3nKfmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGtOOTJiY3XscJMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMD6wNFM1KM7:TT6= MlOzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEm0PFYoRjJ2NUi5OFg3RC:jPh?=
SF539 NH76RpVEgXSxdH;4bYNqfHliYYPzZZk> NVSzTHRbS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0Z3M{mgZ4VtdHNiYomgV3JDKGG|c3H5MEBIUTVyIE2gNE4xODN4IN88UU4> MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
293T MWjGeY5kfGmxbjDhd5NigQ>? Mn\MN|AhdWmwcx?= MUfJcohq[mm2aX;uJI9nKGi3bXHuJGhFSUNzIHX4dJJme3OnZDDpckBpfW2jbjCyPVNVKGOnbHzzJJV{cW6pIFHjMWtIVEeNKFHjLU1OS0FiYYOgd5Vje3S{YYTlJIFnfGW{IEOwJI1qdnNiYomg[ox2d3Knc3PlcoNmKGG|c3H5MEBKSzVyIE2gNE4xODN4IN88UU4> Mm\PQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEm0PFYoRjJ2NUi5OFg3RC:jPh?=
DMS114 M1jjWmN6fG:2b4jpZ4l1gSCjc4PhfS=> NY\LNWNIS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hTE2VMUG0JINmdGy|IHL5JHNTSiCjc4PhfUwhT0l3MDC9JFAvODB|NjFOwG0v MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
U251 M2L6[2N6fG:2b4jpZ4l1gSCjc4PhfS=> NWTMXVRrS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXTJ3MTDj[YxteyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAxOzlizszNMi=> NVr5ZZJlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
SF295 NV\uV|JHS3m2b4TvfIlkcXS7IHHzd4F6 MofjR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2YzQTViY3XscJMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMD6wNFQh|ryPLh?= NGPqbnY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW4PVQ5Pid-MkS1PFk1QDZ:L3G+
MCF7 NELpdY5EgXSxdH;4bYNqfHliYYPzZZk> NUHVfGZVS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAxPDJizszNMi=> M2qyWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUi5OFg3Lz5{NEW4PVQ5PjxxYU6=
OVCAR3 NU\lc|lKS3m2b4TvfIlkcXS7IHHzd4F6 NUTxcWJWS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hV1[FQWKzJINmdGy|IHL5JHNTSiCjc4PhfUwhT0l3MDC9JFAvODB2NjFOwG0v M2T2O|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUi5OFg3Lz5{NEW4PVQ5PjxxYU6=
NCI-H23 MXXDfZRwfG:6aXPpeJkh[XO|YYm= NXLC[WkzS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVkOLLViyN{Bk\WyuczDifUBUWkJiYYPzZZktKEeLNUCgQUAxNjByNE[g{txONg>? Mo\ZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEm0PFYoRjJ2NUi5OFg3RC:jPh?=
SF268 MX\DfZRwfG:6aXPpeJkh[XO|YYm= M1q4PGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNHOjZ6IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFA1QSEQvF2u MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
MKN7 MlTuR5l1d3SxeHnjbZR6KGG|c3H5 MniyR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWtPPyClZXzsd{BjgSCVUlKgZZN{[XluIFfJOVAhRSByLkCwOFkh|ryPLh?= NV3JVm86RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
OVCAR8 MVzDfZRwfG:6aXPpeJkh[XO|YYm= M{\3VWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG9XS0GUODDj[YxteyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAxPTVizszNMi=> NWW4OJhERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
MDA-MB-231 MoK0R5l1d3SxeHnjbZR6KGG|c3H5 MVvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHL5JHNTSiCjc4PhfUwhT0l3MDC9JFAvODB3NTFOwG0v M3nhcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUi5OFg3Lz5{NEW4PVQ5PjxxYU6=
DMS273 M3L6SWN6fG:2b4jpZ4l1gSCjc4PhfS=> NV;kZ|VqS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hTE2VMkezJINmdGy|IHL5JHNTSiCjc4PhfUwhT0l3MDC9JFAvODB3ODFOwG0v NHLGTnc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW4PVQ5Pid-MkS1PFk1QDZ:L3G+
DU145 MofrR5l1d3SxeHnjbZR6KGG|c3H5 MmG0R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gSHUyPDViY3XscJMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMD6wNFYh|ryPLh?= NVHITItTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
RXF631L M1rrbWN6fG:2b4jpZ4l1gSCjc4PhfS=> NXP2OlczS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWliINkOxUEBk\WyuczDifUBUWkJiYYPzZZktKEeLNUCgQUAxNjByNk[g{txONg>? MnnsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEm0PFYoRjJ2NUi5OFg3RC:jPh?=
HBC4 M2fte2N6fG:2b4jpZ4l1gSCjc4PhfS=> NGjSdmtEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJSkN2IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFA3QSEQvF2u NW\HVlR7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
SNB75 NH64RWJEgXSxdH;4bYNqfHliYYPzZZk> MWDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTUmI4PSClZXzsd{BjgSCVUlKgZZN{[XluIFfJOVAhRSByLkCwO|Ih|ryPLh?= MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
BSY1 MmXlR5l1d3SxeHnjbZR6KGG|c3H5 M2TBbmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGJUYTFiY3XscJMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMD6wNFg2KM7:TT6= M1LwTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUi5OFg3Lz5{NEW4PVQ5PjxxYU6=
NCI-H226 NYXLdpI3S3m2b4TvfIlkcXS7IHHzd4F6 NW\FRVlXS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVkOLLViyNlYh[2WubIOgZpkhW1KEIHHzd4F6NCCJSUWwJF0hOC5yMEi5JO69VS5? NWP2PWVKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
SNB78 NFHrRnREgXSxdH;4bYNqfHliYYPzZZk> NF;m[WdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUVkJ5ODDj[YxteyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAxQTZizszNMi=> NWfxUWgzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
HBC5 MX7DfZRwfG:6aXPpeJkh[XO|YYm= NFjwc|ZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJSkN3IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFE{KM7:TT6= M3;idVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUi5OFg3Lz5{NEW4PVQ5PjxxYU6=
MKN45 NGrGNGVEgXSxdH;4bYNqfHliYYPzZZk> MUHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNT241PSClZXzsd{BjgSCVUlKgZZN{[XluIFfJOVAhRSByLkCxOEDPxE1w NXfC[HBSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
MKN28 NWfEUXA{S3m2b4TvfIlkcXS7IHHzd4F6 NX;S[5ZES3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUuQMkigZ4VtdHNiYomgV3JDKGG|c3H5MEBIUTVyIE2gNE4xOTdizszNMi=> NWTO[XJuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
PC3 NVzTRVV3S3m2b4TvfIlkcXS7IHHzd4F6 MXTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOgZpkhW1KEIHHzd4F6NCCJSUWwJF0hOC5yMUig{txONg>? NFXVUWw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW4PVQ5Pid-MkS1PFk1QDZ:L3G+
ACHN MlrqR5l1d3SxeHnjbZR6KGG|c3H5 MoToR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRWNJViClZXzsd{BjgSCVUlKgZZN{[XluIFfJOVAhRSByLkCyJO69VS5? NYezTlRvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
OVCAR4 Mk\YR5l1d3SxeHnjbZR6KGG|c3H5 NEntfYxEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBQXkODUkSgZ4VtdHNiYomgV3JDKGG|c3H5MEBIUTVyIE2gNE4xOiEQvF2u NVjMb291RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
St-4 MmDWR5l1d3SxeHnjbZR6KGG|c3H5 MVTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTeE01KGOnbHzzJIJ6KFOUQjDhd5NigSxiR1m1NEA:KDBwMEKyJO69VS5? MkHNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEm0PFYoRjJ2NUi5OFg3RC:jPh?=
293T MnP2SpVv[3Srb36gZZN{[Xl? M3rmVVMxKG2rboO= Mke0TY5pcWKrdHnvckBw\iCvb4Xz[UBJTEGFNjDlfJBz\XO|ZXSgbY4hcHWvYX6gNlk{XCClZXzsd{B2e2mwZzDBZ{1MT0yJSzjBZ{kuVUODIHHzJJN2[nO2cnH0[UBi\nSncjCzNEBucW6|IHL5JIZtfW:{ZYPj[Y5k\SCjc4PhfUwhUUN3MDC9JFAvOzlizszNMi=> NHXaelQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW4PVQ5Pid-MkS1PFk1QDZ:L3G+
HCT15 NXfSNXZiS3m2b4TvfIlkcXS7IHHzd4F6 Mn3yR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGNVOTViY3XscJMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMD60OUDPxE1w NGHUc5k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW4PVQ5Pid-MkS1PFk1QDZ:L3G+
mink Mv1Lu NHfQe5RHfW6ldHnvckBie3OjeR?= M2D1SlI1KGi{cx?= M2HtSmlv[3KnYYPlJIlvKGi3bXHuJJdqdGRidInw[UBxOjFicILveIVqdiCneIDy[ZN{cW:wIHnuJI1qdmtiTY[xUJUh[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IICyNUBxem:vb4TldkBie3OjeTDpckBxemW|ZX7j[UBw\iByLkGgcW0h\Gm2aHnveIhz\Wm2b3ysJGVEOTByMDC9JFAvODF3NzFOwG0v NEPMTpI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm5O|U4QCd-MkS5PVc2Pzh:L3G+
HCT116 MWnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M3PsV|Q5KGi{cx?= M2nBZmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFPUNVE3KGOnbHzzJIFnfGW{IES4JIhzeyCrbjDwdoV{\W6lZTDv[kBFXFRiYomgUXRVKGG|c3H5MEBKSzVyIE2gNE4xODNizszNMi=> NIW3U3k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUG0O|YyOid-MkWxOFc3OTJ:L3G+
MOLT4 M3nXbWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NX\UOmN6PzJiaILz MofCRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPT1zUOEBk\WyuczDh[pRmeiB5MjDodpMh[nliQ1PLPEBie3OjeTygS2k2OCB;IECuNFAzODZizszNMi=> MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjN|MUOzOEc,OjZ|M{GzN|Q9N2F-
DU145 MXjBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M4XmblczKGi{cx?= MoHGRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCGVUG0OUBk\WyuczDh[pRmeiB5MjDodpMh[nliQ1PLPEBie3OjeTygS2k2OCB;IECuNFAzPTVizszNMi=> MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjN|MUOzOEc,OjZ|M{GzN|Q9N2F-
U937 M1z4VmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 Mn7RO|IhcHK| MXrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFV7M{egZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KEOFS{igZZN{[XluIFfJOVAhRSByLkCwN|QyKM7:TT6= MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjN|MUOzOEc,OjZ|M{GzN|Q9N2F-
HLF NGK4U4VCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NE[0bmw4OiCqcoO= MY\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiORjDj[YxteyCjZoTldkA4OiCqcoOgZpkhS0ONODDhd5NigSxiR1m1NEA:KDBwMEC0PFkh|ryPLh?= NV;lb4I4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zN|E{OzRpPkK2N|MyOzN2PD;hQi=>
WI38 NUPqU4J2SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MojJO|IhcHK| MXLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFeLM{igZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KEOFS{igZZN{[XluIFfJOVAhRSByLkCwOVM6KM7:TT6= MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjN|MUOzOEc,OjZ|M{GzN|Q9N2F-
U937 MYLGeY5kfGmxbjDhd5NigQ>? M2PpbFI1KGi{cx?= NX\Scnd4UW6qaXLpeIlwdiCxZjDISGFEPiCrbjDoeY1idiCXOUO3JINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iCjbIDoZU11fWKrbHnuJIFk\XS7bHH0bY9vKGG2IEWgcm0hfG9iNTD1UUBi\nSncjCyOEBpenNiYomgW4V{fGW{bjDicI91KGGwYXz5d4l{ MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjN|MUOzOEc,OjZ|M{GzN|Q9N2F-
HCT116 NEHRZlRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MmTMO|IhcHK| Mm\wRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ2SxNVYh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImgbY5kfWKjdHXkJIZweiB5MjDodpMh[nliY3;1cJRmeiClb4XueIVzKG2ndHjv[EwhUUN3MDC9JFAvODJ6IN88UU4> Mo\OQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2OEG2OVkoRjJ4NEixOlU6RC:jPh?=
IGROV1/Pt1 NXW4VmlpSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NVW4VIpKPzJiaILz NEDHVYpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFnHVm9XOS:SdEGgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliaX7jeYJifGWmIH\vdkA4OiCqcoOgZpkh[2:3bITldkBkd3WwdHXyJI1mfGixZDygTWM2OCB;IECuNFgh|ryPLh?= MkXUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2OEG2OVkoRjJ4NEixOlU6RC:jPh?=
IGROV1 M1ywZ2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 Ml30O|IhcHK| NGr2NmtCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFnHVm9XOSClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDjc5VtfGW{IHPveY51\XJibXX0bI9lNCCLQ{WwJF0hOC5{MjFOwG0v NF6wNnM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkS4NVY2QSd-Mk[0PFE3PTl:L3G+

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p21 / Cyclin D1; 

PubMed: 19682393     


NIH 3T3 cells stably expressing the indicated proteins were treated with DMSO (Vehicle) or the indicated concentration of romidepsin for 24 h. Cell lysates were analyzed by western blotting with antibodies to cyclin D1, p21 and β-actin (loading control). Data shown are representative of at least two independent experiments.

AcH3(K9) / Ac-α-Tubulin(K40) / Ac-NFκB2(K310) p65 / 3MeH3(K27); 

PubMed: 26473529     


Effects of romidepsin (Rom) on the levels of acetylated proteins and related enzymes. Cells were exposed to romidepsin for 48 h and total cell extracts were analyzed by western blot.

HDAC3 / HDAC4 / HDAC6 / HDAC2; 

PubMed: 26473529     


Effects of romidepsin (Rom) on the levels of acetylated proteins and related enzymes. Cells were exposed to romidepsin for 48 h and total cell extracts were analyzed by western blot.

γH2AX / PARP1 / Cleaved caspase3 / BAK / p21(waf1/cip1) / XIAP; 

PubMed: 26473529     


Western blot analysis of proteins involved in DNA-damage response and apoptosis. Established cell lines were exposed to different concentrations of romidepsin (Rom) for 48 h and total cell extracts were analyzed.

Cyclin E1 / BRCA1 / E2F1 / Cleaved PARP / H3Ac; 

PubMed: 27444036     


Western blot analysis of the effects of panobinostat (25 nM), vorinostat (5 µM) and romidepsin (10 nM) on expression of cyclin E1, E2F1, BRCA1, cleaved PARP and acetylated histone H3 in OVCAR-3 cells. Actin and histone H3 were loading controls. 

pAKT(S473) / pAKT(T308) / AKT; 

PubMed: 25492515     


Western blot analysis of phosphorylated AKT in PC3 cells. Cells were treated for 3 h with various concentrations of FK228. 

19682393 26473529 27444036 25492515
Growth inhibition assay
Cell viability; 

PubMed: 27444036     


Concentration-dependent effects of panobinostat and vorinostat in SRB viability assays in OVCAR-3 cells (72 h). Values are mean+SE of 3 independent experiments. 

27444036
Immunofluorescence
SS18/TLE1; 

PubMed: 27120803     


A significant decrease in detectable PLA signal following HDAC inhibition in SYO-1 cells.

Cleaved caspase-3; 

PubMed: 22531354     


TDP-B activates cleaved caspase-3 by immunofluorescence. Representative immunofluorescence staining for cleaved caspase 3 (green) in SKOV-3 ovarian cancer cells treated with 10 nM FK228, TDP-A or TDP-B after 24 h of exposure. The nuclei are stained with DAPI (blue).

27120803 22531354
体内研究 与PBS处理的对照组相比,单独使用Erlotinib 和 Romidepsin分别可以对NCI-H1299细胞系的异种移植生长抑制到72% 和 43% ,但是并不具有明显的统计学意义。只有当两种药物联用的时候才会对其生长造成明显的抑制作用,此时生长被抑制到28% [1]。在免疫功能低下的小鼠中,Romidepsin 会抑制皮下NB 异种移植的生长,这种抑制作用具有剂量依赖的特性 。此外, 在NB病人的肿瘤组织中Romidepsin 会诱导某些基因的表达,如 p21 和p75 以及NTRK (TrkA) [2]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

- 合并

HDAC-inhibitory activity:

For the enzyme assay, 10 μL of [3H]acetyl-labeled histones (25,000 cpm/10 μg) are added to 90 μL of the HDAC enzyme fraction extracted from 293T cells overexpressing HDAC1 or HDAC2 in the presence of increasing concentrations of Romidepsin, and the mixture is incubated at 37 °C for 15 minutes. The enzyme reaction is linear for at least 1 hour. The reaction is stopped by the addition of 10 μL of concentrated HCl. The released [3H]acetic acid is extracted with 1 mL of ethylacetate, and 0.9 mL of the solvent layer is taken into 5 mL of aqueous counting scintillant II solution for determination of radioactivity. The IC50 values are determined from at least three independent dose-response curves.
细胞实验:[3]
- 合并
  • Cell lines: NCI-H1975, NCI-H157, NCI-2882, NCI-H460 和 HCC95 细胞系
  • Concentrations: 1 ng/mL
  • Incubation Time: 72 小时
  • Method: 使用MTS法分析药物敏感性。在96孔平板中每孔接种2×103个细胞(包括NCI-H1975, NCI-H157, NCI-2882, NCI-H460和HCC95) 。24小时后, 在存在或者缺少1 ng/mL Romidepsin的条件下将细胞与不同浓度 (0.01 µM - 250 µM) 的Erlotinib 37°C 孵育72 小时。 MTS 溶液加到每个孔中37°C孵育1小时。利用分光光度计测量490 nm 处的光密度值。每种药物浓度的实验都设置8个复孔并重复两次。基于细胞生存曲线的吸光度值计算药物的半抑制浓度 (IC50) 。
    (Only for Reference)
动物实验:[5]
- 合并
  • Animal Models: 携带NCI-H1299 细胞的 BALB/c无胸腺裸小鼠
  • Dosages: 1.2 mg/kg
  • Administration: 腹腔注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 10 mg/mL (18.49 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
2% DMSO+30% PEG 300+5%Tween 80+ddH2O
5mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 540.7
化学式

C24H36N4O6S2

CAS号 128517-07-7
储存条件 粉状
溶于溶剂
别名 FR 901228, NSC 630176

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03770000 Active not recruiting Drug: Tenalisib|Drug: Romidepsin T Cell Lymphoma Rhizen Pharmaceuticals SA March 12 2019 Phase 1|Phase 2
NCT02616965 Recruiting Drug: Romidepsin|Drug: Brentuximab vedotin Cutaneous T-cell Lymphoma (CTCL) Fox Chase Cancer Center|Seagen Inc.|Celgene Corporation February 22 2017 Phase 1
NCT02616874 Completed Drug: MVA.HIVconsv vaccine|Drug: Romidepsin HIV IrsiCaixa|Germans Trias i Pujol Hospital|Fundación FLS de Lucha Contra el Sida las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia|Hospital Clinic of Barcelona|Hospital de Sant Pau|HIVACAT|University of Oxford|BCN Checkpoint February 2016 Phase 1
NCT03141203 Active not recruiting Drug: Romidepsin|Drug: Carfilzomib Peripheral T Cell Lymphoma University of Birmingham|Bloodwise|Celgene|Amgen July 13 2015 Phase 1|Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

HDAC Signaling Pathway Map

HDAC Inhibitors with Unique Features

相关HDAC产品

Tags: 购买Romidepsin (FK228, Depsipeptide) | Romidepsin (FK228, Depsipeptide)供应商 | 采购Romidepsin (FK228, Depsipeptide) | Romidepsin (FK228, Depsipeptide)价格 | Romidepsin (FK228, Depsipeptide)生产 | 订购Romidepsin (FK228, Depsipeptide) | Romidepsin (FK228, Depsipeptide)代理商
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID