Vorinostat (SAHA, MK0683)

目录号:S1047 别名: SAHA, MK0683, suberoylanilide hydroxamic acid

Vorinostat (SAHA, MK0683) Chemical Structure

Molecular Weight(MW): 264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA)是一种HDAC抑制剂,无细胞试验中IC50为~10 nM。

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客户使用Selleck该产品发表文献104篇:

客户使用该产品的20个实验数据:

  • Activity of vorinostat in Jurkat and Peer T-ALL cell lines in an MTT cell viability assay. Cells were treated with increasing drug concentrations for 72 h. The data are plotted as the mean % of DMSO-treated control cells against the corresponding drug concentration. The error bars are the standard error. For each drug and cell line, 3-4 independent experiments were performed with 6 replicates at each drug concentration.

    Nature 2011 471, 235-9. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Differential effects of HDAC inhibitors on histone and tubulin acetylation. Immunofluorescence analysis of histone H3 (K9ac/K14ac) and tubulin acetylation in HeLa cells treated for 4 h with vehicle, SAHA (10 μM), tacedinaline (50 μM), PCI-24781 (20 μM. (a) Mapping of histone acetylation in K562 cells treated with HDAC inhibitors by LC-MS/MS. Cells were treated with TSA (10 μM), SAHA (5 μM), PCI-24781 (2 μM), tacedinaline (50 μM) for 6 h. Histones were extracted from cells and acetylated peptides were quantified after isobaric tagging.

    Nat Biotechnol 2011 29, 255-265. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Western blot analysis of histone H3 acetylation in the spleen of untreated and vorinostat-treated hNF-E2 tg mice (n = 4 of each genotype).

    J Exp Med 2012 209, 35-50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA down-regulates c-FLIP expression and increases the sensitivity of CaP cells to undergo apoptosis in the presence of bicalutamide (A) Bar graph illustrating the sub-G0/G1 cell population in 22Rv1 (left panel) and LNCaP (right panel) cells in the absence and presence of 10μM bicalutamide, administered as a single agent or in ombination with increasing concentrations of the HDAC inhibitor, SAHA. (B) Immunoblots demonstrating the single agent activity of bicalutamide or SAHA, or effect upon their combined administration on the expression of c-FLIP and/or the processing of PARP. Equal protein loading was confirmed by GAPDH. (C) Bar graph illustrating the effect of bicalutamide and SAHA upon the induction of caspase-8 or caspase-3/7 activity in 22Rv1 cells (left panel) and LNCaP cells (right panel). (D) Immunoblots characterizing the impact of SAHA and/or bicalutamide upon the induction of PARP cleavage, in the absence or presence of the pan-caspase inhibitor, ZIETD. ZIETD was incubated with the cells for 12 h prior to the experiment. All data points shown in (A) and (C) represent the mean ± S.E.M. value, calculated from four independent experiments.

    Clin Cancer Res 2012 18, 3822-33. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Analyses of efficacy, potency and IC50 of HDAC inhibitors point toward HDACs 1–3 as relevant candidates for beta cell protection. Ranking and raw data on ITF drugs (Table 3) and commercial HDAC inhibitors (Table 4) underlying the heat maps of Fig. 1 (A and B). The HDAC inhibitor compounds were tested using a HDAC activity kit and recombinant proteins to determine IC50 values on each individual HDAC (right part of the table). Each drug was further tested using Real-Time Cell Analysis (RTCA) to score their maximal effective concentration (ECmax) as well as the corresponding rescue percentage of cytokine treated INS-1 cells. The drugs were ranked according to % rescue. * DMSO alone controls were included in each experiment, but not shown here. The results indicate that the highest concentrations of DMSO used here (1:1,000) were slightly potentiating the proliferation of the cells. The effects observed in this group of compounds were ascribed to the DMSO.?

    Diabetologia 2012 55, 2421-2431. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Suberoylanilide hydroxyamic acid (SAHA) preserves CFP (+) expression in mouse optic nerves (MONs) from older mice. (a) CFP (+) mitochondria were longer and thicker in MONs from 12-month-old Thy-1 CFP mice (inset; scale bar = 2 μm). Oxygen–glucose deprivation (OGD) consistently reduced CFP pixel intensity in 12-month-old MONs despite longer and brighter CFP ( +) mitochondria (yellow arrows). (b) Blockade of AMPA/kain ate receptors with NBQX (30 μM), or pan-Histone deacetylase (HDAC) inhibition with SAHA (5 μM), effectively preserved CFP pixel intensity during OGD. The preservation of CFP (+) mitochondria correlates with protection of the CAP area during OGD and profound recovery.

    J Neurochem 2012 123 Suppl 2, 108-15. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • D and E, Regression of IL-13Ra 2-negative pancreatic tumors treated with SAHA and/or IL-13-PE. Mice were treated daily with i.p. injection of SAHA (25 mg/kg) from day 4 after tumor implantation for two weeks followed by i.t. injection of IL-13-PE (100 μ g/kg) from day 5 for two weeks. F and G, Regression of IL-13Ra 2-posotive pancreatic tumors (HS766T and MIA-PaCa2) treated with SAHA and/or IL-13-PE. The schedule of treatment was similar as in panel D and E. Statistical significances are shown by *: P < 0.05,†: P < 0.001.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

    IL-13Rα2 expression is upregulated in pancreatic tumors but not in organs of mice after treatment with HDAC inhibi tor, SAHA. A, qRT-PCR of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. Tumors were harvested next day after IL-13-PE treatment and total RNA extracted. Data shown is ratio of human IL-13Rα2/β-actin expression and multiplied by 1000 for convenience. Bars , SD of triplicate determinations. B, qRT-PCR of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Tissues were harvested at the same time point as in panel A and total RNA extracted. Data shown is ratio of mouse IL-13Rα2/β-actin expression and multiplied by 100 for convenience. C, IHC of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. D, IHC of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Liver, brain, kidney, pancreas, lung and spleen were fixed for immunostaining of mouse IL-13Rα2 as visualized by Alexa555. Nucleus was counterstained by DAPI.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Proliferation o f HT29 and HCT116 cells after 48 h of butyrate or SAHA treatment. Proliferation measurements using the xCEL Ligence RTCA DP instrument (Roche) in cells treated with increasing doses of butyrate or SAHA, compared with control medium cells (0) (*P < 0.05). The mean ?SEM of three cell culture replicates is shown.

    Mol Carcinog 2012 52, 459-74. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA induces the down-regulation of cFLIP expression and promotes TRAIL-mediated activation of a mitochondrial-operated apoptotic pathway. a BT-474 cells were treated as indicated in Fig. 1 and the cells were then harvested to analyse caspase-8, Bid, caspase-9, caspase-3 and PARP expression, using GAPDH as the protein loading control. b BT-474 cells were treated with SAHA for 8 h at the doses indicated and subsequently, the cells were harvested and the apoptosis-related proteins were analysed in western blots as described in the "Materials and Methods". The results shown are representative of at least three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Treatment with SAHA sensitizes breast cancer cells to TRAILinduced apoptosis. BT-474 and MDA-MB-231 cells were incubated for 8 h with SAHA at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some of the cultures for an additional 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content as described in the "Materials and methods". The results show the mean and S.E.M. of three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA facilitates the Itch/AIP4-independent proteasomal degradation of cFLIP proteins in breast cancer cells. a BT-474 cells were treated with SAHA (5 μM) for 8 h in the presence or absence of the proteasome inhibitors MG132 or epoxomicin (at the doses indicated), and they were then harvested and the cFLIP content was analysed in western blots. b BT-474 cells were transfected with either the siRNA oligonucleotides targeting Itch/AIP4 or the non-targeting RNA oligonucleotide (scrambled) for 48 h as described in the "Materials and Methods". Subsequently, the cells were treated with SAHA (5 μM) for 8 h and then cFLIP and Itch/AIP4 expression was analysed in immunoblots

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • cFLIP down-regulation following SAHA treatment is responsible for the sensitization of breast cancer cells to TRAIL. a BT-474 cells were transfected with either different siRNAs directed against the cFLIP isoforms or the non-targeting RNA oligonucleotide (scrambled) as described in the "Materials and Methods". After 24 h, the cells were treated with TRAIL (500 ng/ml) for a further 15 h and apoptosis was then measured as the percentage of cells with subG1 DNA content. The results show the mean and S.E.M. of three independent experiments. To verify protein knockdown, cells were harvested 24 h after transfection and the cFLIP levels were assessed in immunoblots. b. BT-474 cells overexpressing Cflipl (pBABE-FLIPL) or control cells (pBABE) were treated with SAHA for 8 h at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some cultures for 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content and the results show the mean and range of two independent experiments. Western blots show the cFLIP levels after SAHA treatment in pBABE and pBABE-FLIPL cells.

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Vorinostat inhibits the tumor growth. NOD ⁄ SCID-B2m-/-mice were injected s.c. with 1×106 MyLa2059 cells into both flanks. When the mice had developed established palpable tumors treatment was initiated (day 1). The mice received either vehicle (black line) or 60 mg ⁄ kg vorinostat (grey line) i.p. five days a week. In total, there were four mice in the group receiving vehicle and three mice in the group receiving vorinostat. The length and width of the tumors were measured continuously until the experiment was terminated on day 20 post treatment initiation. The tumor volume was calculated using the formula V = (a×b2)/2, where a defines the length (mm) and b the width (mm) of the tumor. The histogram shows the average tumor volume per flank ± SEM. * denotes a significant difference (P < 0.05) in the average tumor volume per flank between mice treated with vehicle and vorinostat at the given time-point both by using a one-tailed two samples test with Welch, scorrection and a Mann-Whitney U test.

     

     

    Exp Dermatol 2010 19, 1096-1102. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Western blot of whole cell extracts demonstrates SAHA and NaB treatment result in increased levels of acetylated histone H3 compared to vehicle controls. (b) Light micrographs of HDACi/vehicle treated cultures illustrate the paucity of neurospheres in HDACi-treated cultures. (c) Quantitative analysis confirms SAHA and NaB inhibit the formation of neurospheres (diameter ≥ 50 μm) and increase the prevalence of small cell clusters (≥ 4 cell, diameter < 50 μm). (d) Flow cytometry using LIVE/DEAD cell stain confirms SAHA and NaB are minimally toxic compared to vehicle controls (n = 3). Scale bar = 100 μm.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    (a) EdU flow cytometry of live cell-gated adult mouse NSCs demonstrates SAHA (**p < 0.01) and NaB (***p < 0.001) significantly inhibit DNA synthesis. (b) Analysis of DNA content by flow cytometry reveals significant accumulation of adult mouse NSCs in G1phase of the cell cycle following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (c) Correspondingly the proportion of cells in G2/M phase is significantly reduced following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (d) Fluorescence micrographs of HDACi/vehicle treated adult NSCs pulse-labeled with EdU for flow cytometry. Scale bar = 50 μm. Statistical comparisons performed using one-way ANOVA with post hoc Newman-Keuls multiple comparison tests.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Immunofluorescence labeling of NeuN, GFAP and Olig2 cell fate markers reveals reduced expression of GFAP (*p < 0.001) and Olig2 (*p < 0.05) in adult mouse NSCs treated with SAHA for 48 hours under proliferation culture conditions and then induced to differentiate for 14 days in culture (two-way ANOVA with Bonferroni post-tests). (b) Western blot of β-catenin protein in nuclear and cytoplasmic fractions of adult mouse NSCs treated with HDACi/vehicle control under proliferation culture conditions. Gapdh and lamin A/C blots are included as loading controls. (c) SAHA and NaB do not significantly alter nuclear/cytoplasmic levels of β-catenin in adult mouse NSCs. Histogram of β-catenin Western blot signal intensities normalized to loading controls (n = 4).

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Morphological changes and histone H3 phosphorylation of HB cells treated with a combination of VX-680 and SAHA. HUH6 and HepT1 were incubated with VX-680 (6 μM) and SAHA (0.5 μM). Nuclei diameter (a) and cell diameter (b) were determined 72 h later by DAPI staining and microscopy. Data represent mean±SD of the diameters from 20 cells in each experiment. (* Two-way ANOVA, Bonferroni test, p \0.05). c Western blot analysis on HUH6 and HepT1 cells were carried out with an anti-phospho-Histone H3 (Ser 10) antibody (p-H3) 24 h after incubation with VX-680 (10 μM), SAHA (0.2 μM) or a combination of both. Controls were left untreated. Western blot analysis showed a decrease in p–H3 after treatment with VX-680 ( lane 2 ) relative to controls ( lane 1 ) and an increase when SAHA was added ( lane 3 ). For the combination of VX-680 and SAHA (lane 4 ) no p-H3 was detected.

    Pediatr Surg Int 2012 28, 579-89. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Vorinostat promotes C2C12 differentiation.In the image, the red is the myotube indicating differentiation ,the blue is the nuclei.

     

     

    Dr. Akihiko Yoshimura of Akihiko Yoshimura. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Western blot analysis of Acetyl-H3 and H3. 0-20μM SAHA was added.

     

     

    Dr. Zhang of Tianjin Medical University. Vorinostat (SAHA, MK0683) purchased from Selleck.

产品安全说明书

HDAC抑制剂选择性比较

生物活性

产品描述 Vorinostat (suberoylanilide hydroxamic acid, SAHA)是一种HDAC抑制剂,无细胞试验中IC50为~10 nM。
特性 Vorinostat是广谱HDAC活性抑制剂,抑制I和II类酶 。
靶点
HDAC [1]
(Cell-free assay)
~10 nM
体外研究

Vorinostat是小分子量(<300)线性肟酸,抑制HDAC活性,包括乙酰化组蛋白和非组蛋白的积累,抑制培养细胞的增殖,且抑制肿瘤生长。Vorinostat通过结合到酶的活性位点而抑制 HDAC活性。Vorinostat 抑制多种转化细胞增殖(包括 淋巴瘤,多发性骨髓瘤,白血病,和非小细胞肺癌),与对照组相比抑制生长达50% 时的浓度为0.5 到10μM。Vorinostat作用于淋巴瘤和白血病细胞,包括 Burkitt, B-细胞急性淋巴细胞白血病 (B-ALL), MCL, DLBCL, ATL和T-细胞,不同程度抑制细胞增殖。除了抑制转化细胞增殖, Vorinostat 也抑制正常细胞增殖,通过比较Vorinostat 作用于一组细胞系–正常人非纤维细胞(WI-38)和 SV40巨大T抗原转化WI-38(VA-13细胞)而得到证明。Vorinostat 抑制两种类型细胞增殖,这种作用存在剂量依赖性。但发现Vorinostat 对转化细胞具有选择毒性,包括使肿瘤细胞死亡,而对正常细胞只起抑制作用,不会使其死亡。[1] Genistein 和Vorinostat 联用效果比5-aza和Vorinostat 联用作用于诱导细胞死亡有效很多。Genistein和Vorinostat联用作用于ARCaP-E使增殖降低 80 %,作用于ARCaP-M细胞,增殖降低60 %以上。Genistein和Vorinostat 联用抑制细胞增殖具有协同效应。作用于ARCaP-E 细胞(820个基因 诱导和1046个基因抑制) ARCaP-M 细胞,Vorinostat比Genistein 影响更多基因。[2] Vorinostat作用于肿瘤细胞表面,提高Fas蛋白水平,这种作用存在剂量依赖性,且按0.75 μM剂量处理,提高达到一个稳定水平。[3] Vorinostat 抑制肿瘤细胞生长,包括NB4, H460 和HCT-116,IC50分别为0.7μM, 3.4μM和1.2 μM。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 M1v3VGtqdmG|ZTDBd5NigQ>? M{Xq[lEhcA>? MoLiSG1UVw>? Mme4ZY51cS2KRFHDNUBi[3Srdnn0fUB4cXSqIFnDOVAhd2ZiMD6xNVIh|ryP MnPxNVE6PjB2OEm=
Friend leukemic cell Mk\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXywOWtRPTBizszN MXy3NkBp NXSzPGdMTE2VTx?= NGO4[VZKSzVyPUCuPVkh|ryP NUHocnQ{OTJzMEm5NVM>
K562 NWXwbnZnU2mwYYPlJGF{e2G7 Moj2OkBp Mm\4SG1UVw>? MXzJcohq[mm2aX;uJI9nKGi3bXHuJIhqe3SxbnWg[IVi[2W2eXzhd4UhMG2reIT1doUhd2ZiSFTBR|Eh[W6mIFjERWMzMSC5aYToJGlEPTBib3[gNE4xOSEQvF2= MX2xNlQyQTN6MB?=
HT1080 NYTXUnRyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXm3NkBp NE\r[mtFVVOR NHrydmhKSzVyPUKuOEDPxE1? MlPmNVIzPzBzN{W=
H1299 MU\LbY5ie2ViQYPzZZk> NFHXRpkzOCCvaX6= MXLEUXNQ NYf1XJREUW6qaXLpeI9zgSCjY4Tpeol1gSCjZ3HpcpN1KEiGQVOg[Y57gW2nIIfpeIghUUN3MDDv[kAxNjF7NDFOwG0> Mmq5NVQ2OjF2MkK=
H1299 MofFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfQdlE4OiCq M{joWmROW09? M2i4WGlEPTB;Nz6yOEDPxE1? NYT1ZYt6OTR3MkG0NlI>
HeLa MljxT4lv[XOnIFHzd4F6 NWrUeZliOzBibXnu M1K4RWlvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDh[4FqdnO2IHjpd5RwdmViZHXhZ4V1gWyjc3Wge4l1cCCLQ{WwJI9nKDBwMkig{txO MV[xOVYxOzl2OR?=
LOX-IMVI NUSzUWZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF73fGE1QCCq M4Tzb2lEPTB;MT6zJO69VQ>? MoTHNVU4OTV2N{C=
NCI-H226 MlzES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU[0PEBp NYX2TplIUUN3ME2yMlYh|ryP M3P1bFE2PzF3NEew
RXF-631L NWCze4pyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWG0PEBp MlPGTWM2OD1{IN88US=> MVyxOVcyPTR5MB?=
SNB-78 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmj4OFghcA>? NVnSdWhZUUN3ME2xOkDPxE1? MV2xOVcyPTR5MB?=
St-4 NFzrPWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{D1SlQ5KGh? MlTVTWM2OD13LkKg{txO NFjtU5kyPTdzNUS3NC=>
ARP1 NWP1Tod{TnWwY4Tpc44hSXO|YYm= M1zFZVIh|ryP M3zteFYhcA>? MnywTY5lfWO2aX;uJI9nKFB{MWfBSlEh\2WwZTDlfJBz\XO|aX;u NFv1cHgyPDd|NEiwOi=>
CEM NFPQN2VMcW6jc3WgRZN{[Xl? NXjBb|FmOSCq NWHUUI1jTE2VTx?= NHPIbYNKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuN|Mh|ryP NFfJUW8yPjR{MEC2OC=>
HCT15 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnCcXpCPDhiaB?= MVPHTVUxRTBwOEKg{txO Ml\ONVY4OjN{Mke=
NCI-H23 Mn7MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DXW|Q5KGh? MmrQS2k2OD1yLkmyJO69VQ>? NEPVWG4yPjd{M{KyOy=>
GM15850 NIrVUWJMcW6jc3WgRZN{[Xl? NWLPUI5oOi53IN88US=> NI\XcHA6PiCq NIDIbphFVVOR MY\Jcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKMzDsfZNqdmViMUSgZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? NUXYfIpYOTZ7MkGzOlc>
GM15850 NIC4R4NMcW6jc3WgRZN{[Xl? MnLXNk42KM7:TR?= MXG5OkBp NEm0VmhFVVOR NY[yVlVQUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFUh[WOndInsZZRqd25ib3[gSnhPKGenbnW= M1zlWVE3QTJzM{[3
GM15850 M1\pS2tqdmG|ZTDBd5NigQ>? NVKxW2dzOi53IN88US=> M33Kdlk3KGh? NIDJNIdFVVOR MXvJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKNDDsfZNqdmViMUKgZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? NVGxNXM6OTZ7MkGzOlc>
GM15850 MXfLbY5ie2ViQYPzZZk> NVHHSWQ1Oi53IN88US=> MmXsPVYhcA>? NFX0RVhFVVOR NXjkTYlKUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFkh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NXzhfWQ2OTZ7MkGzOlc>
GM15850 MXLLbY5ie2ViQYPzZZk> NIP0dlYzNjVizszN MXG5OkBp MVfEUXNQ NYf6doNsUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFgh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NWGyXpZrOTZ7MkGzOlc>
GM15850 MlnXT4lv[XOnIFHzd4F6 NXP0VlFIOi53IN88US=> NGfpRmc6PiCq MWLEUXNQ M2q2VWlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTCxOkBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= MUWxOlkzOTN4Nx?=
U937 M3[xVWZ2dmO2aX;uJGF{e2G7 MVe1JO69VQ>? MUSyOEBp MVjEUXNQ MUfD[YxtKGO7Y3zlJIFzemW|dDDifUBi[2O3bYXsZZRqd25iYYSgV{9IOi:PIIDoZZNm MX6xO|AxPDdzOB?=
H661 M3vsWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVu0PEBp NYL3dI9GUUN3ME2xJO69VQ>? MmW3NVcyPTdyMEm=
U937 MnyzSpVv[3Srb36gRZN{[Xl? NF32eJU2KM7:TR?= NWHpTJJzOjRiaB?= NHTGdmNFVVOR NF\Wdm1KdmO{ZXHz[UBqdiCqaYP0c45mKEh|IHHj[ZR6dGG2aX;u NYrJSWVrOTd2NEe3OVA>
U937 MlXNSpVv[3Srb36gRZN{[Xl? MYOxJO69VQ>? NEnOeW0zPCCq M4LFemROW09? M1LKUmVn\mWldDDvckBidHCqYTD0eYJ2dGmwIHHj[ZR6dGG2aX;u MoD5NVc1PDd5NUC=
RAW264.7 MWHGeY5kfGmxbjDBd5NigQ>? NFHNfJQyOCEQvF2= MoDmNlRp MlrPe4F1\XJ? NXLMTnhJUW6qaXLpeIlwdiCxZjDMVHMue3SrbYXsZZRm\CCWTl\hcJBp[SCycn;keYN1cW:wIIfpeIghUUN3MDDv[kAxNjd4IN88US=> M2\GNVE4PDd5NUG4
RAW264.7 MoHBSpVv[3Srb36gRZN{[Xl? NEHpcYkyOCEQvF2= MUWyOIg> NX;jT5puf2G2ZYK= M2m2XmlvcGmkaYTpc44hd2ZiTGDTMZN1cW23bHH0[YQhVk9icILv[JVkfGmxbjD3bZRpKEmFNUCgc4YhOS56ODFOwG0> MXmxO|Q4PzVzOB?=
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Primary bronchial epithelial cell NH;Qb5pMcW6jc3WgRZN{[Xl? NUfmcHdPOSEQvF2= MVO5OkBp MXfEUXNQ MULJcohq[mm2aX;uJI9nKEiGQVO3JIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIIPoc5J1KGOrcnP1bZQh[3W{cnXueJM> NUP4[ow5OTl7Nk[3PFk>
BxPC3 M4\uWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDEVmg4OiCq NYWxRo1jUUN3ME2yMlch|ryP NGK1[IkzODF2M{e3PC=>
CAL27 NUTE[5A1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYO3NkBp M3uz[GlEPTB;Mz63NkDPxE1? M{jzWlIxOTR|N{e4
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HCC827 Mn75S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjLblE4OiCq NUD6VJY1UUN3ME2xMlgh|ryP NIX1c4szODF2M{e3PC=>
LNCAP Mmj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfZO|IhcA>? NH31XlRKSzVyPUCuOVgh|ryP NF3z[lUzODF2M{e3PC=>
NCI-H2122 Mk\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUK3NkBp M4rQWGlEPTB;Nz61JO69VQ>? MXeyNFE1Ozd5OB?=
NCI-H358 MkDSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPXXJg4OiCq MlnvTWM2OD1{LkWg{txO MYGyNFE1Ozd5OB?=
SCC15 MnG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mor3O|IhcA>? NEHEN41KSzVyPUKuOFkh|ryP M3\QNlIxOTR|N{e4
SCC25 Mn;LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUG3NkBp MmrjTWM2OD1zLkmzJO69VQ>? MUGyNFE1Ozd5OB?=
SKHEP1 Mk\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX[3NkBp M3;RWGlEPTB;Mz60OkDPxE1? NGLOcFczODF2M{e3PC=>
BJ NIHMcXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVS0PGJsOTByIN88US=> M3XyclQ5KGh? NGfuUodFVVOR MkK1S5Jwf3SqIHnubIljcXSrb36gZZQhOC5yNTD0c{AyODBidV2= M3vVS|IxOTR|OESw
MUF M2TReWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4X2O|ExOCEQvF2= M2fxWlQ5KGh? NYfk[nl7TE2VTx?= MY\Hdo94fGhiaX7obYJqfGmxbjDheEAxNjB3IITvJFExOCC3TR?= M2T5d|IxOTR|OESw
Caco-2 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zxNlExOCEQvF2= MVe0PIg> NYjuNGtZTE2VTx?= MWfJR|UxRThwMTFOwG0> M{e3SlIxOTR|OESw
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Caco-2 NXrJNpZ4U2mwYYPlJGF{e2G7 MXqwMlMyPiCwTTD0c{A{OS54IN88US=> NFiyeWg1KGh? M13UTGROW09? NXfyPWxHTXhidnn2c{BqdmirYnn0bY9vKG:oIHj1cYFvKEiGQVOxJJdqfGhiSVO1NEBw\iByLkGxPUDPxE1? M1HKWlIxOTR|OESw
Caco-2 M3rLPGtqdmG|ZTDBd5NigQ>? M4fWSlAvOzF4IH7NJJRwKDNzLk[g{txO MUG0JIg> Mmi2SG1UVw>? NYrIOYJMTXhidnn2c{BqdmirYnn0bY9vKG:oIHj1cYFvKEiGQVOzJJdqfGhiSVO1NEBw\iByLkG0O{DPxE1? M1PpR|IxOTR|OESw
Caco-2 NFjMVWZMcW6jc3WgRZN{[Xl? M3XGb|YvOzJibl2geI8hPjN{IN88US=> NWPUW494PCCq MWHEUXNQ NWrmZmVxTXhidnn2c{BqdmirYnn0bY9vKG:oIHj1cYFvKEiGQVO1JJdqfGhiSVO1NEBw\iBzMj62JO69VQ>? NWrtRZBQOjBzNEO4OFA>
Caco-2 NWPBNoJtU2mwYYPlJGF{e2G7 MnvBOk4{OiCwTTD0c{A3OzJizszN M2XES|QhcA>? M2\qSmROW09? NEjlbVdGgCC4aY\vJIlvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{ege4l1cCCLQ{WwJI9nKDRzIN88US=> MWWyNFE1Ozh2MB?=
Caco-2 M4j0PGtqdmG|ZTDBd5NigQ>? MlXBNE4{OTZibl2geI8hOzFwNjFOwG0> NWDpfndOPCCq NWLYRYJ4TE2VTx?= M3TZO2V5KH[rdn:gbY5pcWKrdHnvckBw\iCqdX3hckBJTEGFNh?= NXS1Vo1jOjBzNEO4OFA>
HepG2 NVHs[Gw2U2mwYYPlJGF{e2G7 M32wc|Uh|ryP MV[2bC=> NHixcoJFVVOR M4LITWlv\HWldHnvckBw\iCKRFHDMY1m\GmjdHXkJIhqe3SxbnWgZYNmfHmuYYTpc44> NUTJdHYyOjBzNEO4OFA>
HepG2 M1P0ZWtqdmG|ZTDBd5NigQ>? M4\j[|Uh|ryP MkHDOog> NYrFbXZ7TE2VTx?= MYDJcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDobZN1d26nIHj5dIVz[WOndInsZZRqd25? M{TYNlIxOTR|OESw
HepG2 NE\3ZmVMcW6jc3WgRZN{[Xl? M3vmcVUh|ryP Mn\qOog> NXTpXpBDTE2VTx?= NX;VNFROUW6mdXP0bY9vKG:oIFjERWMudWWmaXH0[YQh[WyyaHGteJVjfWyrbjDhZ4V1gWyjdHnvci=> M{PVbFIxOTR|OESw
HepG2 NELCSJNMcW6jc3WgRZN{[Xl? NULXVIdqPSEQvF2= Ml;3Oog> MVzEUXNQ M4HUVmlv\HWldHnvckBw\iCKRFHDMY1m\GmjdHXkJGg{N0h2IHjpd5RwdmViYXPleJlt[XSrb36= NEfmWo8zODF2M{i0NC=>
COLO205 NVjYTGpRU2mwYYPlJGF{e2G7 Ml20NVAh|ryP Mm\INlQhcA>? MmfOSG1UVw>? NYftc20yUW6qaXLpeIlwdiCxZjDISGFEOSCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4YhcGm|dH;u[UBJOyCjY3X0fYxifGmxbjD3bZRpKEmFNUCgc4YhOi5{IN88US=> Mm\wNlA1PTF|N{i=
SCC4 NELHOZhMcW6jc3WgRZN{[Xl? NXnsXZdkOSEQvF2= MoXHNlRp M3LqPGlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjD0eYJ2dGmwIHHj[ZR6dGG2aX;u NGftOWwzODR3MkKyOS=>
SCC4 NEe3R2pMcW6jc3WgRZN{[Xl? Mlz1NUDPxE1? M3TyTFI1cA>? NVTDR4VOUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgZYNmfHmuYYTpc44> MnLtNlA1PTJ{MkW=
SCC4 NWfPNFBFTnWwY4Tpc44hSXO|YYm= NVvaeZdZOSEQvF2= M1XsV|UhdWmw MX\B[49vcXO2IHHjeIl3cXS7IHH0JHZFWiCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4YhS1mSMkSg[4Vv\SCneIDy[ZN{cW:w M4TEUlIxPDV{MkK1
NB4 MX7GeY5kfGmxbjDBd5NigQ>? M4fnbFUh|ryP NHzhN5IzPCCq NH\iflRFVVOR NFf0WmtE\WyuIHP5Z4xmKGG{cnXzeEBie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDhZ4N2dXWuYYTpc44h[XRicILlMWcyKHCqYYPl M3vWO|IxPDlzNESw
NB4 NYPRXJE1U2mwYYPlJGF{e2G7 M1HqPVUh|ryP M3TYUlI1KGh? Mly4SG1UVw>? MV3Jcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iYXPleJlt[XSnIIT1ZpVtcW5ibHX2[Yw> MofNNlA1QTF2NEC=
NB4 MkW4SpVv[3Srb36gRZN{[Xl? NX\jdlFnPSEQvF2= NXKzbYFYOjRiaB?= M3\tdGROW09? MYDJcoR2[3Srb36gc4YheDJzV1HGNU9EUVBzIHX4dJJme3Orb36= MXKyNFQ6OTR2MB?=
NB4 Mn65T4lv[XOnIFHzd4F6 NXf5d4llPSEQvF2= M4f6UFI1KGh? NXnrbldZTE2VTx?= NFrhVVJKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIN{Bi[2W2eXzheIlwdg>? NGTyTWczODR7MUS0NC=>
NUGC3 M4PQRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7wXFlrT0l3ME2yMlk1KM7:TR?= M3i1XlIxQDVyOUex
A549 NUGze5JYTnWwY4Tpc44hSXO|YYm= NWLDTZU6PSEQvF2= MVezJIg> MUHEUXNQ NFvUTGdKdmS3Y4Tpc44hd2ZiYYX0c5Bp[We7IHnuJIh2dWGwIFG1OFkh[2WubIOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iTFOzTWk> NFPWdmUzODh3NUKwPC=>
HUT78 NV:xSVB7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXr5Vow{PzJiaB?= MlLaSG1UVw>? MWrHTVUxRTBwMzFOwG0> MV6yNFg5PDJyOB?=
U937 M4D1bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvCO|IhcA>? NFnnUpVFVVOR M33jfGdKPTB;MD6zPUDPxE1? MnHUNlA5QDR{MEi=
A431 NHrVZ3dEgXSxdH;4bYMhSXO|YYm= NGTqUGw4OiCq MUXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOFMyKGOnbHzzJI93\XKneIDy[ZN{cW6pIFXHSnIhf2m2aDDJR|UxKG:oIESuNkDPxE1? M162O|IyODhyNkK5
A549 Mn7oR5l1d3SxeHnjJGF{e2G7 NVX6cpFLPzJiaB?= MonBR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{BwfmW{ZYjwdoV{e2mwZzDISGFEKHerdHigTWM2OCCxZjCxMlgh|ryP Mo\UNlExQDB4Mkm=
CAL27 NVLXWHliS3m2b4TvfIlkKEG|c3H5 MYS3NkBp M{fjcGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNCVDJ5IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGVITlJid3n0bEBKSzVyIH;mJFMvOiEQvF2= MoHyNlExQDB4Mkm=
HeLa NWnKTlVKS3m2b4TvfIlkKEG|c3H5 NVLC[3loPzJiaB?= NH3GZlREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhFSUNid3n0bEBKSzVyIH;mJFEvPSEQvF2= NH7vZ|kzOTB6ME[yPS=>
Sf21 Mnm4T4lv[XOnIFHzd4F6 M3O1RVMhcA>? Mn;QTY5pcWKrdHnvckBw\iCIbHHnJJRi\2enZDDoeY1idiC{ZXPvcYJqdmGwdDDISGFEQCCneIDy[ZN{\WRid3n0bEBKSzVyIH;mJFEvOiEQvF2= MX[yNVA5ODZ{OR?=
SKBR3 M3noemN6fG:2b4jpZ{BCe3OjeR?= NWG4TFMxPzJiaB?= MYfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTT2JTOyClZXzsd{BwfmW{ZYjwdoV{e2mwZzDISXIzKHerdHigTWM2OCCxZjCyMlYh|ryP MYSyNVA5ODZ{OR?=
SKOV3 MWTDfZRwfG:6aXOgRZN{[Xl? NIPGSZM4OiCq NEjWOoNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUU0:YMzDj[YxteyCxdnXy[ZhxemW|c3nu[{BJTVJ{IIfpeIghUUN3MDDv[kAzNjJizszN NFX2SmkzOTB6ME[yPS=>
COR-L23 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLZWXRROTBizszN MnywO|IhcA>? MoLxSG1UVw>? M4HoPGdKPTB;MT6xJO69VQ>? M2T3c|IyODhyNkS3
DU145 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LMR|ExKM7:TR?= MlOzO|IhcA>? MmnaSG1UVw>? MmfmS2k2OD1zLkC1JO69VQ>? NV;rNpJ4OjFyOEC2OFc>
LoVo MlX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLkNVAh|ryP MYC3NkBp M{LadGROW09? Ml;RS2k2OD1zLkeg{txO M1fQVFIyODhyNkS3
MCR5-SV2 NVzhXmhjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPLOFlmOTBizszN NFrXRWQ4OiCq NVn0NI4zTE2VTx?= Mo\hS2k2OD1{LkGg{txO MVGyNVA5ODZ2Nx?=
HCT116 MXjLbY5ie2ViQYPzZZk> NU[5Nms6OzBizszN NYPNVYR1OzBiaB?= NYjOfnhGTE2VTx?= NUm2NVdZUW6qaXLpeIlwdiCxZjDISGFEPiCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4Yh[WyyaHGteJVjfWyrbjDhZ4V1gWyjdHnvci=> NVvHU|Z4OjFyOEC2OFc>
HCT116 NVHYNG91U2mwYYPlJGF{e2G7 MmnlN|Ah|ryP Mn:2N|AhcA>? NGj2dWJFVVOR NVP6[GhjUW6qaXLpeIlwdiCxZjDISGFEOSCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4YhcGm|dH;u[UBJO0t7IHHj[ZR6dGG2aX;u MoDINlExQDB4NEe=
U937 NFTSPW1McW6jc3WgRZN{[Xl? MYi1JO69VQ>? Mne4NlQhcA>? MYXEUXNQ MomyTY5pcWKrdHnvckBw\iCqaYP0c45mKGGlZYT5cJRz[W6|ZnXyZZNmKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIH;mJIFk\XS7bHH0bY9vKG:oIHjpd5RwdmViSEOgZZQhUzl? NGfn[VIzOTJ7MkS5Ni=>
U937 NFrxb|FMcW6jc3WgRZN{[Xl? M1XaXlUh|ryP MknZNlQhcA>? M3rGNGROW09? NYXGeIViUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGGlZYT5cIF1cW:wIH;mJIhqe3SxbnWgTFMh[XRiS{G4 MoPONlEzQTJ2OUK=
U937 M1L5PGtqdmG|ZTDBd5NigQ>? Ml7POUDPxE1? MmPCNlQhcA>? M{nObGROW09? NITrUoNKdmirYnn0bY9vKG:oIHjpd5RwdmViYXPleJltfHKjboPm[ZJie2ViYYPz[ZN{\WRiYYOgbY5kemWjc3Wgc4YheGGwLXHj[ZR6dGG2ZXSgbIl{fG:wZTDIOEBt\X[nbB?= M3nQVlIyOjl{NEmy
U937 MWLLbY5ie2ViQYPzZZk> MUW1JO69VQ>? NIjSR|UyPSCvaX6= NXTVVHVJTE2VTx?= Mk\5TY5pcWKrdHnvckBw\iCqaYP0c45mKGGlZYT5cJRz[W6|ZnXyZZNmKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIH;mJIhqe3SxbnWgTFMh[WOndInsZZRqd25ibHX2[Yw> NEn0VVgzOTJ7MkS5Ni=>
A2780 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHy[II6PiCq MYTEUXNQ NIDXUpRKSzVyPUGuOlIh|ryP M3HEWlIyPjN2NEOw
COLO205 MnXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE[1VoE6PiCq NWm4VHlXTE2VTx?= NXXMTHE6UUN3ME2yMlEzKM7:TR?= Ml7jNlE3OzR2M{C=
Hep3B M1vVTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjLN|FxPDhiaB?= MYDEUXNQ NH2zdlhIUTVyPUGuNlEh|ryP NV\n[lF3OjF5MUKxOFY>
GM11272 MnTkSpVv[3Srb36gRZN{[Xl? NGnEUJcyODBibl2= M2\S[lczKGh? NYXNeZNFTE2VTx?= MmTjVoVi[3SrdnH0bY9vKG:oIF3lR5AzKG23dHHueEBmgHC{ZYPzbY9vKGG2IEGwJJRwKDFyMDDuUS=> M37LcVIyQDRyN{G2
CFBE41o M2Pke2tqdmG|ZTDBd5NigQ>? MV61JO69VQ>? M2jnd2ROW09? NHPrTXNFd3ewIILl[5Vt[XSrb36gc4YhUESDQ{egZZQhOC5{IITvJFUhfU1? MUSyNVk5PDl3OB?=
CFBE41o M3vm[GZ2dmO2aX;uJGF{e2G7 NYTtcYJGOSEQvF2= NE\GWYYzPCCq MWXEUXNQ M1zEc3Jme3SxcnH0bY9vKG:oIFPGWHIh\GWudHHGOVA5KG23dHHueEB1emGoZnnjb4lv\yC2bzDj[YxtKHO3cn\hZ4Uh[XNiZ3z5Z49nd3Kvcx?= MYeyNVk5PDl3OB?=
DU145 MnmzT4lv[XOnIFHzd4F6 MWKyMlUh|ryP M2f5elI1KGh? NED0NWRFVVOR NYnKS|d2UW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IIXwdoVofWyjdHnvckBw\iCyMkH3ZYYyKHC{b4TlbY4h\XiycnXzd4lwdg>? MnG3NlIzPjBzNk[=
DU145 Ml3yT4lv[XOnIFHzd4F6 NXrFcnpFPSEQvF2= NES0W|czPCCq NUTiSmVKTE2VTx?= Mnr0TY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGirc4TvcoUhUDRiYXPleJlt[XSrb36= MVSyNlI3ODF4Nh?=
DU145 Mn3uT4lv[XOnIFHzd4F6 NEmxWIQ2KM7:TR?= NVjIdWIzOjRiaB?= NGTscpNFVVOR MnrSTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGirc4TvcoUhUDNiaInw[ZJi[2W2eXzheIlwdg>? MYKyNlI3ODF4Nh?=
786-0 Mn\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF2xbWk3NjJizszN NWLhfGF1PzJiaB?= MmX5SG1UVw>? MUfHTVUxRTNwMjFOwG0> M2rveFIzPDN3Nk[5
A498 NX;ycWxoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;Fb|hpPi5{IN88US=> M4\MWlczKGh? NUXN[pNRTE2VTx?= Mn\4S2k2OD1zLk[g{txO MmDiNlI1OzV4Nkm=
A549/ATCC MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\GeJBwPi5{IN88US=> NEPPU4w4OiCq NYTsWG1LTE2VTx?= M4jjNmdKPTB;MT62JO69VQ>? MlLrNlI1OzV4Nkm=
ACHN MlPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkj3Ok4zKM7:TR?= MX63NkBp NITne5dFVVOR MkHGS2k2OD1zLkOg{txO NHjPXXozOjR|NU[2PS=>
BT549 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPCOk4zKM7:TR?= NXy4O4hQPzJiaB?= NVPhV4o6TE2VTx?= NGW0eIhIUTVyPUGuN{DPxE1? MYeyNlQ{PTZ4OR?=
EKVX NIDFWY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWC2MlIh|ryP M1nTdlczKGh? MXrEUXNQ NHziboRIUTVyPUGuN{DPxE1? NGXuUIIzOjR|NU[2PS=>
HCT15 NWrlenhzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPkOk4zKM7:TR?= NIXrWGs4OiCq MX;EUXNQ M2HYbGdKPTB;Mj61JO69VQ>? MmrpNlI1OzV4Nkm=
HOP92 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvTU4o3NjJizszN NIXQPGc4OiCq M2TMcmROW09? MmThS2k2OD12IN88US=> MUKyNlQ{PTZ4OR?=
IGROV1 NV;rS4xoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWe2MlIh|ryP MY[3NkBp NGTGPWtFVVOR NVTqfmJtT0l3ME2xMlMh|ryP MUOyNlQ{PTZ4OR?=
LOXIMVI M4LoWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH70flM3NjJizszN M3H6SFczKGh? MXXEUXNQ NHf5cYxIUTVyPUGg{txO NGfFcXYzOjR|NU[2PS=>
M14 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzXNJY3NjJizszN NFjDfFY4OiCq M{XRVWROW09? NX;Je|JqT0l3ME2xMlMh|ryP MUKyNlQ{PTZ4OR?=
MALME-3M M{TnTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3neYE3NjJizszN M{njR|czKGh? NIXmTYhFVVOR NVLn[FJ5T0l3ME2wMlMzKM7:TR?= MoDuNlI1OzV4Nkm=
MCF10A MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3BOZR4Pi5{IN88US=> MmL1OFghcA>? NEC4dYFFVVOR MVvHTVUxRTlwNjFOwG0> MU[yNlQ{PTZ4OR?=
MDA-MB-435 NXPRNm1vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\ESlYvOiEQvF2= M4\ORlczKGh? NETte4ZFVVOR MkLlS2k2OD1yLkWg{txO NEXiOWgzOjR|NU[2PS=>
MDA-MB-468 NYDWTZljT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LLSVYvOiEQvF2= M3HiNFczKGh? M3zIbGROW09? NYXWdXV[T0l3ME2wMlY{KM7:TR?= NIm1S2szOjR|NU[2PS=>
MOLT4 MmD4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUC2MlIh|ryP M{W5RlczKGh? NEDofIdFVVOR NFm2WFJIUTVyPUCuOEDPxE1? MY[yNlQ{PTZ4OR?=
NCI-ADR-RES M2LKS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLJOk4zKM7:TR?= MWS3NkBp MlTQSG1UVw>? NIT5THVIUTVyPUCuNVYh|ryP M1vrSVIzPDN3Nk[5
NCI-H23 M{G4Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LRbVYvOiEQvF2= Mn\FO|IhcA>? NWXW[IdFTE2VTx?= NHvUSWZIUTVyPUGg{txO NXu4bGZGOjJ2M{W2Olk>
NCI-H322M M4DsR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2T5RVYvOiEQvF2= MYC3NkBp MW\EUXNQ MlPGS2k2OD1yLke5JO69VQ>? NEHuUIkzOjR|NU[2PS=>
NCI-H460 MlfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWe2MlIh|ryP MY[3NkBp NILXcnFFVVOR MmHyS2k2OD1yLke5JO69VQ>? NVXuXWRpOjJ2M{W2Olk>
NCI-H522 NGnIcHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWK2MlIh|ryP MnvhO|IhcA>? MXLEUXNQ Mm[3S2k2OD1yLkWg{txO NXPN[GI3OjJ2M{W2Olk>
OVCAR3 Mo\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV62MlIh|ryP NWLvNZNzPzJiaB?= NWTSXYNYTE2VTx?= NUHSZVFuT0l3ME2xMlMh|ryP NYjUcZp3OjJ2M{W2Olk>
OVCAR4 Mn;jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXq0TnBDPi5{IN88US=> MnWxO|IhcA>? NXnUVXF7TE2VTx?= M{\WWGdKPTB;NDFOwG0> NYrxbJM3OjJ2M{W2Olk>
OVCAR5 NIfPbFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjpNFU3NjJizszN M4Djc|czKGh? MoHVSG1UVw>? M4rUXGdKPTB;MD63PUDPxE1? NXLXZlFkOjJ2M{W2Olk>
OVCAR8 NWSxc4RjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHodlc3NjJizszN M3jiU|czKGh? M4fDfWROW09? M{j3dmdKPTB;MD61JO69VQ>? NVW1U|NVOjJ2M{W2Olk>
RXF393 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTjOk4zKM7:TR?= NFPXN|g4OiCq NFHONWlFVVOR M4jJeGdKPTB;MT6zJO69VQ>? MVOyNlQ{PTZ4OR?=
SF268 MlLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nSW|YvOiEQvF2= NYrWdpZZPzJiaB?= NYmzboVVTE2VTx?= NFPDXHFIUTVyPUGuOkDPxE1? NF61OWwzOjR|NU[2PS=>
SF295 Mn\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXO2MlIh|ryP NHHv[444OiCq NITtXZVFVVOR M{HkVWdKPTB;MT62JO69VQ>? NFf5[44zOjR|NU[2PS=>
SF539 M4\WNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXuOk4zKM7:TR?= NGK3V4Y4OiCq MojtSG1UVw>? MX;HTVUxRTJizszN NEn1V2szOjR|NU[2PS=>
SK-MEL-2 NVnTeIVrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjjWmxCPi5{IN88US=> Mo\vO|IhcA>? MmrJSG1UVw>? NGjVdFlIUTVyPUGuN{DPxE1? M2HT[lIzPDN3Nk[5
SK-MEL-28 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3KwblYvOiEQvF2= MUC3NkBp NG\POVBFVVOR NXjWWIRWT0l3ME2xJO69VQ>? MUCyNlQ{PTZ4OR?=
SK-MEL-5 M{Wwb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPMVlZJPi5{IN88US=> NUXqZYd2PzJiaB?= Mn[ySG1UVw>? MVTHTVUxRTBwNkOg{txO Mo\DNlI1OzV4Nkm=
SKOV3 NWPGSVVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnmW2Y3NjJizszN MlfOO|IhcA>? MnS3SG1UVw>? NFrjTVdIUTVyPUGg{txO Mk\4NlI1OzV4Nkm=
SN12C NYjQVnZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXi2MlIh|ryP NGXlelk4OiCq Mkm3SG1UVw>? MlLsS2k2OD1{IN88US=> MnjDNlI1OzV4Nkm=
SNB19 Ml3wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M32yOlYvOiEQvF2= M3;tS|czKGh? NWrPe41YTE2VTx?= MoTDS2k2OD1yLk[zJO69VQ>? MXWyNlQ{PTZ4OR?=
SNB75 NGnsbolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\hOk4zKM7:TR?= M{\ZZlczKGh? NVvodXQ4TE2VTx?= MYDHTVUxRTBwN{mg{txO MoHWNlI1OzV4Nkm=
SR NY\3SVBOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnRZlVJPi5{IN88US=> NVfUcZVWPzJiaB?= MWPEUXNQ M2LaemdKPTB;MD60JO69VQ>? MVOyNlQ{PTZ4OR?=
T47D NIS3XHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfP[ZlZPi5{IN88US=> M{jYZlczKGh? NUPF[Wx2TE2VTx?= NV7SS2tuT0l3ME2wMlUh|ryP MX:yNlQ{PTZ4OR?=
TK10 MmDaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX22MlIh|ryP M37lSVczKGh? NWPye|YxTE2VTx?= MX\HTVUxRTBwNkOg{txO MUWyNlQ{PTZ4OR?=
UACC257 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofUOk4zKM7:TR?= MlSzO|IhcA>? MYnEUXNQ MX7HTVUxRTBwNTFOwG0> NH:0ZXkzOjR|NU[2PS=>
UACC62 M1[wT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnvdGg3NjJizszN MnrlO|IhcA>? NWPYeHNiTE2VTx?= M{PGeGdKPTB;MD60JO69VQ>? NInUemszOjR|NU[2PS=>
UO31 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHTN2Y3NjJizszN Mme3O|IhcA>? NHm0em5FVVOR MXvHTVUxRTBwNTFOwG0> NVnPeI1kOjJ2M{W2Olk>
Hep3B NXPnRoRXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXKOFghcA>? NHr1RnhFVVOR MYPHTVUxRTBwNkmg{txO MUOyNlQ{QTh4Mx?=
BE(2)-C NHuxVJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1GzUVczKGh? MWXEUXNQ MlrGTWM4OD1{IN88US=> NEjKWmYzOjl|MkOxOi=>
Bel7402 NWXnbpBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPk[4Q4OiCq NYrBbWV3TE2VTx?= MYPHTVkxRTF5IN88US=> NVHi[2ZjOjNyNkGzO|Y>
Bel7404 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\VfJk4OiCq M2LLRmROW09? NXjjUWdQT0l7ME2xPEDPxE1? M4\YR|I{ODZzM{e2
BGC823 NFnveG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXrVlVXPzJiaB?= NG\DS2VFVVOR NG\lfHRIUTlyPUeuOUDPxE1? M1zoPFI{ODZzM{e2
MGC803 MoTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjRO|IhcA>? M2jmbmROW09? NW\tfGFlT0l7ME2xNE45KM7:TR?= NFXB[okzOzB4MUO3Oi=>
SGC7901 MmnWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXy3NkBp M3qy[mROW09? MknpS2k6OD17LkSg{txO NHnNPGMzOzB4MUO3Oi=>
SKHEP1 M37lemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfzO|IhcA>? MnH3SG1UVw>? NGnBcGdIUTlyPUG3JO69VQ>? NXT1NIxTOjNyNkGzO|Y>
SMMC7721 NFf6XXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7CZnNjPzJiaB?= MYPEUXNQ NXP0bmhmT0l7ME2yNEDPxE1? MUOyN|A3OTN5Nh?=
NUGC3 M4S0eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLz[Y0yOCEQvF2= NHKwdYpIUT1{Lkm0JO69VQ>? M4jQ[FI{OTZ|M{Oy
A2780 CisR MUjLbY5ie2ViQYPzZZk> NIj1TmIyQCCq MlT5TY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkS0JO69VQ>? NVHse41JOjN{NUK2NFM>
CAL27 sens MWLLbY5ie2ViQYPzZZk> NGXkU40yQCCq MoDMTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkO2JO69VQ>? MlrvNlMzPTJ4MEO=
CAL27 CisR NWjGOVZFU2mwYYPlJGF{e2G7 NGXDOXcyQCCq MXfJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNkGg{txO Mli1NlMzPTJ4MEO=
KYSE-510 CisR M13zbmtqdmG|ZTDBd5NigQ>? MWixPEBp NX\pS5ZDUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlU6KM7:TR?= NVP1NGp4OjN{NUK2NFM>
KYSE-510 sens MmmyT4lv[XOnIFHzd4F6 NWnIbW1oOThiaB?= M1r3V2lvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD63JO69VQ>? NHL6eYEzOzJ3Mk[wNy=>
MDA-MB-231 sens NVrLVmplU2mwYYPlJGF{e2G7 NHvqSVcyQCCq MoTjTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLk[xJO69VQ>? NIPCVGozOzJ3Mk[wNy=>
MDA-MB-231 CisR NYL1VW9DU2mwYYPlJGF{e2G7 M4q2OFE5KGh? NGnEZWtKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOlEh|ryP M13he|I{OjV{NkCz
ES2 M4Hk[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXVOFghcA>? MY\EUXNQ Mmj5TWM2OD1zMj63JO69VQ>? M2raU|I{PDl|NES5
MDA-MB-231 NILLcnFMcW6jc3WgRZN{[Xl? NY\5WmM2OTBizszN M{fKUFMxKG2rbh?= NVf1RW1RTE2VTx?= NHrnNJRKdmirYnn0bY9vKG:oIFjERWMz[Q>? MmnRNlM1QTN2NEm=
MDA-MB-231 Ml;kT4lv[XOnIFHzd4F6 NWXtb4ZOOSEQvF2= NFfncVUzPCCq NXz4TZBTTE2VTx?= M1fCT2lvcGmkaYTpc44hd2ZiSFTBR|Yh[XO|ZYPz[YQh[XNiYXPleJlt[XSrb36gcIV3\Wy|IH;mJJR2[nWuaX6= NVLiNHRrOjN2OUO0OFk>
HS68 NVvJRYpSS3m2b4TvfIlkKEG|c3H5 Ml21NVAh|ryP NXL4elV2PzJiaB?= MUPEUXNQ MXTJR|UxRTRwNjFOwG0> M{Cx[|I{PTdyNUSy
MEF M33ZNGN6fG:2b4jpZ{BCe3OjeR?= MkDKNVAh|ryP NG[0Zok4OiCq NETtPZhFVVOR NFXTUXdKSzVyPUSuOEDPxE1? MY[yN|U4ODV2Mh?=
BGC823 NXXkdHdyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zIW2ROW09? MYfHTVUxRTNwMEmg{txO NI\zNVQzOzZyMUewOi=>
High5 MXXLbY5ie2ViQYPzZZk> NFnMb5AzPCCq MnPGTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCKRFHDOkB4cXSqIFnDOVAhd2ZiMD6wPUDPxE1? NGTvW2gzOzZyMkWyNy=>
High5 NGnHOZBMcW6jc3WgRZN{[Xl? MkjTNlQhcA>? NH65V4NKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjERWMyKHerdHigTWM2OCCxZjCwMlEzKM7:TR?= Ml;ENlM3ODJ3MkO=
High5 MVXLbY5ie2ViQYPzZZk> Ml7wNlQhcA>? NXTFXnZ2UW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDISGFEOyC5aYToJGlEPTBib3[gNE4yPyEQvF2= MoLBNlM3ODJ3MkO=
A549 NEfrb2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlH0SG1UVw>? M2XnW2lEPTB;MT6wO|kh|ryP MUWyN|Y1PDJzMB?=
HCT116 NWDhdZlPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInMeGRFVVOR MlfmTWM2OD1yLke1O{DPxE1? M4HIZlI{PjR2MkGw
K562 NVX2cFR2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XsV2ROW09? Mn7TTWM2OD1yLk[0OUDPxE1? NH;KR5kzOzZ2NEKxNC=>
GBC-SD M1jMPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DTZ|Uh|ryP NV\1bmVEPzJiaB?= Ml;1SG1UVw>? MVvJR|UxRTF2Lkig{txO NGW2RpUzOzdyN{K2NC=>
HGC27 M4jubGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmj3OUDPxE1? NFLqN|g4OiCq NHrUb5lFVVOR NXT1[nFLUUN3ME21MlQh|ryP M3TMTFI{PzB5Mk[w
HL60 MnXQT4lv[XOnIFHzd4F6 MXy1JO69VQ>? NUfNcmRnOjRiaB?= NWm4PY5ITE2VTx?= NIW0OndKdmirYnn0bY9vKG:oIFjERWM> NETk[IMzOzdyN{K2NC=>
Vero NVv1TWJiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3zd484OiCq NFjNN5hFVVOR MnzCTWM2OD1yLkmg{txO NVzhcJpHOjN5OE[0OVI>
NCI60 MoT2R5l1d3SxeHnjJGF{e2G7 NX\3bXZGPDhiaB?= M4TGRWROW09? NGnE[|JIUT1yLkWzJO69VQ>? NWjOXlhROjRyMUWzNlc>
SW620 MoDxR5l1d3SxeHnjJGF{e2G7 NEL0eoQ1QCCq NUn6UFN3TE2VTx?= NETPSpZIUT1yLkW0JO69VQ>? NXTISYdNOjRyMUWzNlc>
U251 NF\yTGlEgXSxdH;4bYMhSXO|YYm= M{npelQ5KGh? MnfMSG1UVw>? M{Pa[WdKRTFwNUOg{txO NVfJcnZvOjRyMUWzNlc>
KM12 MWnDfZRwfG:6aXOgRZN{[Xl? M2n0R|Q5KGh? NYTVZVJbTE2VTx?= M2XlV2dKRTFwOEig{txO Mn;sNlQxOTV|Mke=
Hs578T MWTDfZRwfG:6aXOgRZN{[Xl? NGLkTmQ1QCCq M{\ObmROW09? M4X1V2dKRTRwOEOg{txO MU[yOFAyPTN{Nx?=
MDA-MB-231 M1\SXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPSOFghcA>? M3fp[WlEPTB;MD6xOkDPxE1? NUThclJHOjRyOUWwNVY>
MCF7 NUfFNFVMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXtOFghcA>? M17DZWdKRTBwNEWg{txO MXeyOFEyQTV3NR?=
MDA-MB-435 MmjMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUi0PEBp MkD0S2k:OC56ODFOwG0> NYK2epZDOjRzMUm1OVU>
AsPC1 Mk\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfFdJNHOzBizszN MkP0OFghcA>? MmqxSG1UVw>? MoO0TWM2OD1|Lk[2JO69VQ>? MWKyOFE5PTN5OB?=
Jurkat E6.1 MoH6T4lv[XOnIFHzd4F6 MoS4NkBp NUnSNYxkTE2VTx?= NIrhXYxKdmirYnn0bY9vKG:oIFjERWM1KHerdHigTWM2OCCxZjCwMlA1KM7:TR?= MVSyOFI3OTh4Mh?=
KG1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY[0PEBp NYDuVFQxUUN3ME2xMlE2KM7:TR?= NGLrOIYzPDV{NUCwNy=>
HEL MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnob4w1QCCq NHXmZXZFVVOR M4nOXmlEPTB;MD60PUDPxE1? Ml[zNlQ3QTRyNUW=
HSC3 Mk[wR5l1d3SxeHnjJGF{e2G7 NH:2bokyOiCq NHrNVFJFVVOR NVLvXFB2UUN3ME2wMlcyKM7:TR?= M{GySlI1PzZ4NU[w
HT-29 NHzzZ3BEgXSxdH;4bYMhSXO|YYm= NEHVXpkyOiCq Mk\NSG1UVw>? NV[4[4ZrUUN3ME2wMlczKM7:TR?= NX;D[4l4OjR5Nk[1OlA>
KB M{LjXmN6fG:2b4jpZ{BCe3OjeR?= NWDmcnJ6OTJiaB?= MV7EUXNQ M3[yU2lEPTB;MD63OUDPxE1? MVKyOFc3PjV4MB?=
H460 MlPFR5l1d3SxeHnjJGF{e2G7 M2XqcVEzKGh? NGXibVZFVVOR M2nDXGlEPTB;MD64NkDPxE1? M{jXNVI1PzZ4NU[w
MONE1 M2fvdmN6fG:2b4jpZ{BCe3OjeR?= M1THTlEzKGh? NYm1R2M6TE2VTx?= MYfJR|UxRTFwMUig{txO NXewVYdyOjR5Nk[1OlA>
MKN45 NHnD[G5EgXSxdH;4bYMhSXO|YYm= NEnGcowyOiCq MWDEUXNQ NX7TSGp1UUN3ME2xMlI2KM7:TR?= M4fS[FI1PzZ4NU[w
TSGH NFz5TGxEgXSxdH;4bYMhSXO|YYm= NVm2RlR[OTJiaB?= M1;TN2ROW09? NYrjTWhLUUN3ME2yMlA6KM7:TR?= NEXJfJEzPDd4NkW2NC=>
HL60 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4T0NFczKGh? MVXEUXNQ Mo\VS2k2OD1yLkmzJO69VQ>? M3LnfVI1QTByNUCw
HEK293 M3jJUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4riXlczKGh? MnPzSG1UVw>? NIDhWWFIUTVyPUGzJO69VQ>? MlvpNlQ6ODB3MEC=
Jurkat MYTDfZRwfG:6aXOgRZN{[Xl? MYGxNFAh|ryP Mo\CO|IhcA>? M3XVTmdKPTB;MD65JO69VQ>? NILVOHEzPDlyMEe0Ny=>
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NB13 NUjBWWVvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHnW5NoUUN3ME2xMlA2PTBzIN88US=> MUHTRW5ITVJ?
SF295 NWXXU3p{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXDe4tSUUN3ME2xMlA3PjJ2IN88US=> Mm\OV2FPT0WU
U-2-OS NIXI[21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\qTWM2OD1zLkC3PVEyKM7:TR?= NYjKcWROW0GQR1XS
NCI-H526 NH:zPXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7hTWM2OD1zLkC4NlkyKM7:TR?= NYnUT3pHW0GQR1XS
KMOE-2 M{\JZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPrTWM2OD1zLkC5OFIzKM7:TR?= MoWwV2FPT0WU
RCM-1 NUPr[m54T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzCfXJKSzVyPUGuNVIyODJizszN MkXZV2FPT0WU
MC116 NIXZOVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjFTWM2OD1zLkGzOlIyKM7:TR?= M4fIWnNCVkeHUh?=
NCI-H1092 NIH1[XNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHrXHZKSzVyPUGuNVU1ODZizszN NXzRdXg4W0GQR1XS
EW-3 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfMTWM2OD1zLkG3NlEzKM7:TR?= M2\wfHNCVkeHUh?=
HCT-116 M4HUPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXHNFJiUUN3ME2xMlE4PzVizszN MV;TRW5ITVJ?
MC-IXC MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\2NmlEPTB;MT6xO|g5OSEQvF2= MljSV2FPT0WU
LB1047-RCC NEPXSmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vzT2lEPTB;MT6xPFMyOiEQvF2= MoHMV2FPT0WU
VM-CUB-1 M{DVdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTMTolKSzVyPUGuNVkyODhizszN MonvV2FPT0WU
NB5 M13DR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTFwMUm4OVYh|ryP MYPTRW5ITVJ?
SKG-IIIa M2Tsfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHpSoRKSzVyPUGuNlM1PjRizszN M2\C[nNCVkeHUh?=
HO-1-N-1 NIftU5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{Ox[WlEPTB;MT6yN|g{PSEQvF2= M4LrfHNCVkeHUh?=
EFO-27 M1rSbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPheY8xUUN3ME2xMlI2ODR|IN88US=> NVnDbXN3W0GQR1XS
MHH-NB-11 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTFwMkizNlkh|ryP NELJOmlUSU6JRWK=
SW620 NUm1dXQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUSzOoRQUUN3ME2xMlI6ODF6IN88US=> MUnTRW5ITVJ?
MOLT-16 NIHlRVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\TTWM2OD1zLkK5O|k4KM7:TR?= MX\TRW5ITVJ?
NTERA-S-cl-D1 NETXe2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;ZXHRsUUN3ME2xMlMyPzZzIN88US=> MYfTRW5ITVJ?
VA-ES-BJ MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3n2SGlEPTB;MT6zNlQ4PyEQvF2= MXfTRW5ITVJ?
HCC1419 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmr0TWM2OD1zLkO0NFI4KM7:TR?= M3\xbHNCVkeHUh?=
NCI-H69 NGjKenVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITOeZZKSzVyPUGuN|QyOTJizszN MYrTRW5ITVJ?
DEL MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTFwM{WxOlIh|ryP NXyyNGVoW0GQR1XS
LXF-289 NXKyNY9CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vFXGlEPTB;MT6zOVI1KM7:TR?= M3XWfHNCVkeHUh?=
EW-11 NETlRWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlv6TWM2OD1zLkO2NFI3KM7:TR?= MVzTRW5ITVJ?
KP-4 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlr6TWM2OD1zLkO3NFg2KM7:TR?= NF7UVnFUSU6JRWK=
NOS-1 MoPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH73bJFKSzVyPUGuOFEyQTRizszN MnLCV2FPT0WU
SK-NEP-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TXcWlEPTB;MT60NVY6OyEQvF2= M{njXXNCVkeHUh?=
LAMA-84 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLWdpRiUUN3ME2xMlQ{QTR3IN88US=> NVzHSnJLW0GQR1XS
ES5 NULFTIhnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vDeWlEPTB;MT60OFMh|ryP MW\TRW5ITVJ?
HuO9 NUi1ZWtIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjYUIZ3UUN3ME2xMlQ2OzZ{IN88US=> M2m3UnNCVkeHUh?=
COLO-684 MljTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITNTVVKSzVyPUGuOFYyOThizszN M1PXTnNCVkeHUh?=
EW-24 NWLVfXpqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTFwNE[1N|Eh|ryP M2qzTHNCVkeHUh?=
BV-173 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvVVHR1UUN3ME2xMlQ4OjlzIN88US=> MmXYV2FPT0WU
NCI-H1770 NVTuNGhXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTFwNEi1N|Yh|ryP NXLlOYlYW0GQR1XS
HuP-T4 NYLFWnNGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3W2bGlEPTB;MT60PVMh|ryP NYHEfZJ4W0GQR1XS
TYK-nu MoHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofkTWM2OD1zLkS5PFUyKM7:TR?= MXTTRW5ITVJ?
YH-13 NWfNeoZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml60TWM2OD1zLkS5PFk1KM7:TR?= NH63eHJUSU6JRWK=
H4 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIO4N4VKSzVyPUGuOVA6OTJizszN M3TpNXNCVkeHUh?=
OVCAR-8 MlPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTFwNUS0O|ch|ryP M4OzWXNCVkeHUh?=
NCI-H23 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfJNJBNUUN3ME2xMlU1PjR3IN88US=> MX3TRW5ITVJ?
ES7 M4PNXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\3PHRPUUN3ME2xMlU1Pzd|IN88US=> NHv4N2VUSU6JRWK=
COR-L88 M1XTO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfTWXRUUUN3ME2xMlU3PDJ2IN88US=> MnvFV2FPT0WU
TI-73 NFX3PHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfFTWM2OD1zLkW5NFYh|ryP MX7TRW5ITVJ?
RT-112 NYXZZYtWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\ONXVKSzVyPUGuOVkzQDRizszN NXjNNmVzW0GQR1XS
HuO-3N1 NHXpd2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXMcZRKSzVyPUGuOVk{QDVizszN Mn\SV2FPT0WU
HC-1 M4j5fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTFwNUm4OlYh|ryP NX3rV|h7W0GQR1XS
HT55 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vCdmlEPTB;MT62OVE{OSEQvF2= MmLSV2FPT0WU
IA-LM MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PlU2lEPTB;MT62PVI4QCEQvF2= NILSRWdUSU6JRWK=
EM-2 MnnjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fmSmlEPTB;MT63NFAyPCEQvF2= Mm\DV2FPT0WU
MHH-ES-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M173XmlEPTB;MT63NFQ{PSEQvF2= Ml\xV2FPT0WU
CAL-27 NXXvSFJvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HMfmlEPTB;MT63NFYzOSEQvF2= MVTTRW5ITVJ?
COLO-800 M3n4fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTuTWM2OD1zLkexNVc6KM7:TR?= NITqfYxUSU6JRWK=
HCE-T MmHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nheWlEPTB;MT63NVUh|ryP M4DqUHNCVkeHUh?=
CAMA-1 NFfSZ3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHG4[mtKSzVyPUGuO|E6PzFizszN NG[4PHVUSU6JRWK=
LOXIMVI MmexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TsfWlEPTB;MT63NlEyKM7:TR?= NYfIcW5EW0GQR1XS
NH-12 M3P0d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmD6TWM2OD1zLkeyOlkyKM7:TR?= NV\tcXo{W0GQR1XS
TCCSUP MkDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHKWZFKSzVyPUGuO|I5OjlizszN M1vTRXNCVkeHUh?=
MDA-MB-361 MkPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTFwN{OxOVch|ryP MkW3V2FPT0WU
EW-16 M{LvUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX2xO49LUUN3ME2xMlc1OTB5IN88US=> NULhSW15W0GQR1XS
SNU-423 NVnRe5V3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLNTWM2OD1zLke1PFI4KM7:TR?= Mo\lV2FPT0WU
Daoy NGnVWGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nGcmlEPTB;MT63OlMyQSEQvF2= MVHTRW5ITVJ?
ES4 Mn6wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1q1XGlEPTB;MT63PFc1OSEQvF2= MWHTRW5ITVJ?
PFSK-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTFwOECzO{DPxE1? M1;6dHNCVkeHUh?=
ES3 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fjfGlEPTB;MT64NlY5OSEQvF2= NYG1[41bW0GQR1XS
ONS-76 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrvUWppUUN3ME2xMlgzQDl5IN88US=> MYrTRW5ITVJ?
JVM-3 NFXGS3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETpWXBKSzVyPUGuPFU1PTFizszN MmnUV2FPT0WU
OS-RC-2 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTFwOEexOVEh|ryP MV\TRW5ITVJ?
COLO-320-HSR M3vCTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPnUFcyUUN3ME2xMlg5OTl5IN88US=> MljCV2FPT0WU
HN Mn;OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUO4[5FOUUN3ME2xMlg5PzJ3IN88US=> NULBVJVSW0GQR1XS
HT NYDpeY9iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7lZ4FKSzVyPUGuPFg6PDdizszN NEDI[HZUSU6JRWK=
LoVo MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXITWM2OD1zLki5PFEh|ryP NF;lbmFUSU6JRWK=
CGTH-W-1 NUjLXJB4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTFwOEm5OFYh|ryP MV7TRW5ITVJ?
NB6 M4TFR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3wTWM2OD1zLkmxNlk5KM7:TR?= NVPJNldUW0GQR1XS
EW-22 M2jCfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTFwOUK4PFch|ryP M3vRbnNCVkeHUh?=
ES6 M3zGcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fJNWlEPTB;MT65N|Y{OSEQvF2= MmTUV2FPT0WU
SCC-15 M4C5NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorZTWM2OD1zLkmzPFE6KM7:TR?= M4Pad3NCVkeHUh?=
HL-60 NYntVlN5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{m2XGlEPTB;MT65N|kxOiEQvF2= M3H2OnNCVkeHUh?=
human HOP-92 NETFS21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjkWFBEUUN3ME2xMlk1ODZ3IN88US=> MXjTRW5ITVJ?
SW626 NHHObGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\vNYJKSzVyPUGuPVQ5QTlizszN M1O4WXNCVkeHUh?=
HEC-1 M3j6OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3P2TGlEPTB;MT65OVM3KM7:TR?= NGjMdo1USU6JRWK=
LB2241-RCC M{C3S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU[xXHRYUUN3ME2xMlk5OjNzIN88US=> NELO[o5USU6JRWK=
Ramos-2G6-4C10 MorGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTFwOUm0PVMh|ryP MV\TRW5ITVJ?
A101D NFX6bGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTJwMkCzNFMh|ryP MU\TRW5ITVJ?
NCI-H446 NHT2Z4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3ftb2lEPTB;Mj6wOFU6QSEQvF2= MkjJV2FPT0WU
SBC-5 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfxdWdKSzVyPUKuNFYyPDdizszN NFzvd|BUSU6JRWK=
HOS MnrVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1[3[2lEPTB;Mj6wO|Y2OyEQvF2= M{m5fHNCVkeHUh?=
K5 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfoOZFMUUN3ME2yMlA4QDFzIN88US=> NFrIUJZUSU6JRWK=
HLE MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPjTWM2OD1{LkC4OVI6KM7:TR?= NYjOXGVVW0GQR1XS
HSC-2 MmTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjpOXlqUUN3ME2yMlEzQDl6IN88US=> M4PxfnNCVkeHUh?=
LCLC-97TM1 M2LDWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXrR4FvUUN3ME2yMlE1PTh|IN88US=> MYDTRW5ITVJ?
DMS-273 NUHpS4VST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnGN4V5UUN3ME2yMlE1QDN5IN88US=> MY\TRW5ITVJ?
TE-8 NVXwU|VmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{Cz[2lEPTB;Mj6xOVc3PSEQvF2= MoTvV2FPT0WU
DSH1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTNTWM2OD1{LkG2N|k5KM7:TR?= MVzTRW5ITVJ?
CAL-51 NXj1SnNnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXn3d5JsUUN3ME2yMlE3Pjl7IN88US=> NH7pR21USU6JRWK=
IST-SL1 NGHqSlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULTV3JvUUN3ME2yMlE3QDR2IN88US=> NUS2fVdjW0GQR1XS
GCT Mn\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTJwMUe3O{DPxE1? NY[2e5l4W0GQR1XS
SW948 NYLIR29HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTXTWM2OD1{LkG4OFU3KM7:TR?= M{XQWXNCVkeHUh?=
NOMO-1 M4Ox[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M12weGlEPTB;Mj6xPVMyPyEQvF2= M3nyWXNCVkeHUh?=
C8166 NV7DSWN2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfGdFNKSzVyPUKuNlE{OzRizszN MmL3V2FPT0WU
OC-314 MoH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFW1WIVKSzVyPUKuNlMzPTlizszN NVzsSWpNW0GQR1XS
CAL-39 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvoOW5KSzVyPUKuNlM3OjZizszN MnLmV2FPT0WU
MDA-MB-453 NHfsfmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTJwMkSyO|Uh|ryP NXGycphjW0GQR1XS
A673 NUjUd2pmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWS3NZpEUUN3ME2yMlI2QDZ{IN88US=> NIXRS|JUSU6JRWK=
HTC-C3 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3H6PWlEPTB;Mj6yOlg2KM7:TR?= NVLDT406W0GQR1XS
NCI-H1666 NEfCc2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fTbWlEPTB;Mj6yPFEyOSEQvF2= M1vq[HNCVkeHUh?=
PSN1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;oTWM2OD1{LkK4PVE{KM7:TR?= M2SyRnNCVkeHUh?=
GI-1 NHzMXpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXGcVlKSzVyPUKuN|A2PDNizszN MlzBV2FPT0WU
HuH-7 NFnWdJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTJwM{C2N|ch|ryP NVPOTXBvW0GQR1XS
JAR NIKwfmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk[2TWM2OD1{LkOxPVg4KM7:TR?= NF:yfY5USU6JRWK=
5637 M1PvZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILvWXNKSzVyPUKuN|IyOjlizszN MmniV2FPT0WU
GB-1 MlPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTBSHRDUUN3ME2yMlMzOzN3IN88US=> NIjUdGVUSU6JRWK=
KP-N-YS M3fIVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGH6cIlKSzVyPUKuN|I3OTVizszN MlTDV2FPT0WU
OAW-42 M4q4S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTJwM{O0NVYh|ryP M2mzXnNCVkeHUh?=
8-MG-BA NUHMVJBjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnUTVd2UUN3ME2yMlM{QTB4IN88US=> M3v2UnNCVkeHUh?=
RH-18 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfoTWM2OD1{LkO1NFIzKM7:TR?= MVfTRW5ITVJ?
NCI-H1155 M1S5R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIOxdYRKSzVyPUKuN|Y4OjVizszN NU\lSYZOW0GQR1XS
NB17 NIj4ZlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33ITGlEPTB;Mj6zPFI1OyEQvF2= M2nVU3NCVkeHUh?=
NCI-H1437 M1fpSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTPV|ZKSzVyPUKuOFE5PzNizszN MU\TRW5ITVJ?
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SW684 NFj2TWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTlwNE[xNVYh|ryP MoPOV2FPT0WU
SH-4 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnX5TWM2OD17LkS5N|Y1KM7:TR?= MV3TRW5ITVJ?
IST-MES1 M4rBZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;ibmt4UUN3ME25MlUyPjR2IN88US=> M{XWOHNCVkeHUh?=
Saos-2 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTlwNUKxPVUh|ryP NF\u[nhUSU6JRWK=
NCI-H2087 NILqSZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rzcWlEPTB;OT62O|M2OiEQvF2= MkPhV2FPT0WU
SCC-9 MmWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXz2fm9OUUN3ME25MlcyQDF4IN88US=> NEjoeIlUSU6JRWK=
MFE-280 NX:5b2NqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXBOGNKSzVyPUmuO|I4QDVizszN NF7qZWxUSU6JRWK=
BEN MmrTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnS0TWM2OD17LkiyNVU6KM7:TR?= MlPZV2FPT0WU
CP50-MEL-B MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTlwOUK0N|Ih|ryP NFH3PGZUSU6JRWK=
SK-MEL-28 NFnSfHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTFyLkCxPVMh|ryP MYDTRW5ITVJ?
NCI-H2452 NWn6SYV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjrfGQyUUN3ME2xNE4yPiEQvF2= NF72OXlUSU6JRWK=
NCI-H1395 NWfUVm5[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fLTmlEPTB;MUCuNVc5KM7:TR?= M4\ZS3NCVkeHUh?=
NCI-H2052 M17JZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LrNWlEPTB;MUCuNVg5OiEQvF2= MnTFV2FPT0WU
A375 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljBTWM2OD1zMD6yOFUzKM7:TR?= MoLCV2FPT0WU
HCC38 MnjTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TrTWlEPTB;MUCuN|IzKM7:TR?= NEfDbJVUSU6JRWK=
LK-2 Mn\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\Z[GlEPTB;MUCuOFIxQCEQvF2= NEDCT49USU6JRWK=
SF126 M4XmVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1X1cGlEPTB;MUCuOFczPyEQvF2= NH\IfoFUSU6JRWK=
SK-MEL-1 NVP4V5JLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULDcmh5UUN3ME2xNE44QDN6IN88US=> MVfTRW5ITVJ?
ACN NInKUnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2n5dmlEPTB;MUCuPFY4QSEQvF2= MUTTRW5ITVJ?
BB30-HNC MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTFyLki3NVEh|ryP Mnf3V2FPT0WU
NCI-H747 NYXwN5pCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDLOGhKSzVyPUGwMlg4PDZizszN NGTrPG5USU6JRWK=
KYSE-150 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTFzLkCzPFch|ryP M{TxdXNCVkeHUh?=
D-247MG NFnnWYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTFzLkGwNFkh|ryP M{LWPXNCVkeHUh?=
BxPC-3 NFGxdodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkf5TWM2OD1zMT6zO|Q4KM7:TR?= MnnjV2FPT0WU
SK-MEL-30 MmPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33hT2lEPTB;MUGuOFA4QSEQvF2= M1rtXnNCVkeHUh?=
CAS-1 NETBeFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HLNGlEPTB;MUGuOFExQSEQvF2= NHPVU29USU6JRWK=
no-10 NXP6co9PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjvcGxwUUN3ME2xNk4yOjF5IN88US=> MofWV2FPT0WU
NCI-H2405 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILNWGxKSzVyPUGyMlIxOzZizszN NH3iUplUSU6JRWK=
KGN M{DrdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPsTlBnUUN3ME2xNk4zQTBzIN88US=> NHfp[lNUSU6JRWK=
BB49-HNC M4fR[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LlUGlEPTB;MUKuN|k2PiEQvF2= MkS3V2FPT0WU
NCI-H1693 NETvTJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnVTGtuUUN3ME2xNk42QDF4IN88US=> M4jjUHNCVkeHUh?=
RO82-W-1 Mn;yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvxU5ZKSzVyPUGzMlA3PDlizszN MWPTRW5ITVJ?
CAL-85-1 NGDaeVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojNTWM2OD1zMz60N|k6KM7:TR?= MWLTRW5ITVJ?
H-EMC-SS NEHDNphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnuTWM2OD1zMz65NVA1KM7:TR?= MWrTRW5ITVJ?
SW1783 NV2zU3JGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvCRmVIUUN3ME2xOE4zOzlzIN88US=> Mn\mV2FPT0WU
LB771-HNC M3;IeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTF2LkSxPUDPxE1? NF;KTZdUSU6JRWK=
HCC70 M3q1Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEH2eIJKSzVyPUG0MlQzOzNizszN MWnTRW5ITVJ?
KNS-81-FD MoL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTRb2tKSzVyPUG0MlcxPDVizszN MYjTRW5ITVJ?
KYSE-520 Mli4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPnbVlKSzVyPUG0MlkzPyEQvF2= Ml6xV2FPT0WU
TGBC24TKB M13tUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYeyW2g3UUN3ME2xOE46PTN7IN88US=> NHrKclJUSU6JRWK=
SNB75 NHXTPVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;icoluUUN3ME2xOU4xPzJ7IN88US=> M4n6NXNCVkeHUh?=
SW872 NWO3XldnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPq[VhKSzVyPUG1MlIzOThizszN NGrkRXpUSU6JRWK=
U031 NWG5ZoxST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3z0OGlEPTB;MUWuPFAzQCEQvF2= NHzPNXNUSU6JRWK=
ChaGo-K-1 MnP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTF3LkizOVkh|ryP NXjye5dJW0GQR1XS
NCI-H441 MnLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPYWZhKSzVyPUG2MlAxOzlizszN M1m5NHNCVkeHUh?=
TE-12 M4W3Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzYWYNKSzVyPUG2MlE5PzNizszN M1q3d3NCVkeHUh?=
NCI-H1755 NH3OcG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{SycGlEPTB;MU[uOVc{KM7:TR?= MXLTRW5ITVJ?
KNS-42 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4f1[2lEPTB;MU[uOlU5QSEQvF2= Ml\1V2FPT0WU
SK-PN-DW NWD5SVhXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PBNWlEPTB;MUeuOFIxOSEQvF2= NF3nTJhUSU6JRWK=
NCI-H226 MlvqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXe3WIpIUUN3ME2xO{46OzR3IN88US=> MnTSV2FPT0WU
K-562 NILRemVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHUVGxZUUN3ME2xPE43OzF5IN88US=> M3LqPHNCVkeHUh?=
A388 NW\KfWExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEK2TIpKSzVyPUG5MlA{ODNizszN MXLTRW5ITVJ?
ZR-75-30 M4fQTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mke2TWM2OD1zOT6wPVY5KM7:TR?= NXjTXIdHW0GQR1XS
LU-135 NGjyZmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzmTWM2OD1zOT6yOlM3KM7:TR?= MmnhV2FPT0WU
NCI-H2029 NVLTOWExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3vTWM2OD1zOT62NFIyKM7:TR?= MWHTRW5ITVJ?
HT-1197 NEK5fVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH2wR4hKSzVyPUG5MlkzOjdizszN MVLTRW5ITVJ?
IGR-1 MlvWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLITWM2OD1{MD6zNVE4KM7:TR?= M164Z3NCVkeHUh?=
U-87-MG NU\2cmdOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\UTWM2OD1{MD62OFE{KM7:TR?= NXjmT3NVW0GQR1XS
NCI-H1304 NUTX[XRKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXTeIs6UUN3ME2yNE44PTBzIN88US=> M4TJd3NCVkeHUh?=
RCC10RGB M4\pemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\GXJpRUUN3ME2yNU4zQDJ7IN88US=> Mnv4V2FPT0WU
NCI-H520 MlvsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DFRmlEPTB;MkKuO|YyOSEQvF2= MVzTRW5ITVJ?
SK-LU-1 NFP6eZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1z4dGlEPTB;MkOuNFcyQCEQvF2= NXTD[m01W0GQR1XS
UACC-893 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYm5fHVkUUN3ME2yN{4yODN6IN88US=> Ml;SV2FPT0WU
NCI-H2347 M3rsTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTJ|LkK2O|Qh|ryP M2f4RXNCVkeHUh?=
U-118-MG NELETZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjCdWJqUUN3ME2yN{44OjF5IN88US=> NHvsZYtUSU6JRWK=
NCI-H596 M3;XOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDnNpJwUUN3ME2yN{46ODV3IN88US=> NFX3cJhUSU6JRWK=
MZ1-PC NUT4W|Y5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfpb2RlUUN3ME2yOE43PzV7IN88US=> MU\TRW5ITVJ?
SW1417 NXvWenQzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrIOVNKSzVyPUK1MlI1QThizszN MYnTRW5ITVJ?
NCI-H82 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTJ4LkSyPFgh|ryP NUXUemtiW0GQR1XS
COLO-678 NHXCZXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\BU5ZKSzVyPUK3MlQ6OTlizszN NIPVSIlUSU6JRWK=
KURAMOCHI MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTJ6LkGyOkDPxE1? NHTrW4NUSU6JRWK=
NCI-H1650 M3LoVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;MSmlEPTB;M{CuNVkzPCEQvF2= M3\rbnNCVkeHUh?=
HCC1954 NWXLVZZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXHUlhzUUN3ME2zNU4{PjZ4IN88US=> MW\TRW5ITVJ?
GAK MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3ITWM2OD1|Mj6yOlE3KM7:TR?= NHK3foJUSU6JRWK=
YAPC NYLCd3dQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoqyTWM2OD1|Mz63OlQ5KM7:TR?= M4XyTnNCVkeHUh?=
NCI-H2228 NHfBU5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLuN5RCUUN3ME2zOE4{PjB3IN88US=> NFHQNIpUSU6JRWK=
VMRC-RCZ NGn0bGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrJW5dKSzVyPUO2MlMxOjJizszN NGjCSHlUSU6JRWK=
NMC-G1 MnzjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTN5LkC1Nlkh|ryP M4CwOnNCVkeHUh?=
D-336MG NYrCNnFRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLwbHRWUUN3ME20NU45PDR{IN88US=> MofTV2FPT0WU
UACC-62 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUW1PFNbUUN3ME20Nk42PTB3IN88US=> M2\VO3NCVkeHUh?=
C-33-A NUjUOYk3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDqNmtKSzVyPUS1MlMzPTZizszN MmPMV2FPT0WU
HCC1937 NV\tenB2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;vd|ZsUUN3ME20O{4yQTV6IN88US=> NVj4T497W0GQR1XS
HDLM-2 NIXacmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTR5LkKyPFch|ryP Mk\pV2FPT0WU
NCI-H727 NI\wTmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTR5LkK0OVEh|ryP M{fvWnNCVkeHUh?=
NY M1;6cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTR7LkO5NFgh|ryP M1PR[3NCVkeHUh?=
NCI-H2291 NGjmOYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTR7LkizNFEh|ryP NXrReZE4W0GQR1XS

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Ac-Histone H4/Ac-Histone H3; 

PubMed: 21598070     


D54 and U87 glioma cells were treated with lower concentrations (1-3 µM) of vorinostat. The effects on histone acetylation was assessed by immunoblotting. 

phospho-CDK1; 

PubMed: 21598070     


Changes in level of inhibitory phosphorylation of cdk1 after treatment with vorinostat was determined at 24 and 48 h (using a Tyr-15 residue phospho-specific antibody) along with total cdk1 as loading control. 

phospho-Cdc25c/Cdc25c; 

PubMed: 21598070     


Time course of changes in phospho-cdc25c levels after exposure to vorinostat (5 µM).

Cyclin B1; 

PubMed: 21598070     


Cyclin B1 levels were determined in D54 and U87 cells after treatment with various doses of vorinostat at 24 and 48 h.

c-Myc/c-Raf/Akt/Cyclin D1/CDK4; 

PubMed: 19440035     


Cell lysates from JeKo-1 and Mo2058 cells exposed to vorinostat  were immunoblotted for c-Myc, c-Raf, AKT, cyclin D1, CDK4 and acetylated histone H3. The levels of β-actin served as the loading control.

p-eIF2α/ATF4/CHOP ; 

PubMed: 20072656     


Western blot was performed to evaluate activated eIF2α (P-eIF2α), translational up-regulation of ATF4, and CHOP expression in U251 cells after vorinostat exposure.

p21; 

PubMed: 21598070     


To determine the dose response relationship to vorinostat, cells were exposed to various higher concentrations (5–10 µM) of the agent and the levels of p21 determined by immunoblotting.

21598070 19440035 20072656
Immunofluorescence
HDAC1/CK19; 

PubMed: 29917299     


Immunocytochemistry to detect the expression of HDAC1 and CK 19 in PDAC cells with/without Vorinostat treatment. HDAC1 and CK19 were stained red and green, respectively. The Hoechst‐stained nuclei appear blue. Scale bar: 100 μm. The CK19 expression in PSN1 and MiaPaCa2 was increased by Vorinostat treatment.

Nrf2; 

PubMed: 20566897     


Vorinostat induced translocation of Nrf2 from cytosol to nucleus. U937 cells were treated with 2μM vorinostat for 18 hours and then cytospun. Cells were fixed and labeled for Nrf2 protein (red) and nucleus (blue, 4,6-diamidino-2-phenylindole) as described in “Immunofluorescence and confocal microscopy.” Images were taken by Nikon Eclipse TE2000 confocal microscope with 40×/1.30 numeric aperture oil objective lens. Ctrl indicates control cells without treatment; and Vor, vorinostat.

α-SMA; 

PubMed: 26330748     


Representative immunofluorescence images and the quantification graph showing the effect of vorinostat (2.5 µM), TGIF1, and TGIF2 siRNA knockdown on αSMA. Control human corneal fibroblast cultures (-TGFβ) showed no αSMA staining. Cultures treated with TGFβ1 (5 ng/ml) showed a robust αSMA staining. Vorinostat treatment markedly attenuated TGFβ-evoked αSMA staining. The knockdown of TGIF1 (+TGFβ+vorinostat+TGIF1siRNA) and TGIF2 alone (+TGFβ+vorinostat+TGIF2siRNA) or in combination (+TGFβ +vorinostat +TGIF1 +2siRNA) markedly blocked the effect of vorinostat on αSMA. Scale bar=100 μm.

Ac-STAT3/IGF2; 

PubMed: 27086926     


Immunofluorescence staining of Ac-STAT3 and IGF2 after vorinostat treatment.

29917299 20566897 26330748 27086926
Growth inhibition assay
Cell apoptosis; 

PubMed: 19440035     


Cells were treated with indicated concentrations of vorinostat for 48 hours. Following this, the percentage of annexin-V-stained apoptotic cells was determined by flow cytometry. Values represented as bar graphs are the mean of 3 experiments plus or minus the standard error (SE)

Cell viability; 

PubMed: 27086926     


The effects of vorinostat on the viability of the indicated NSCLC cell lines and their corresponding acquired VoR sublines. Cell viability was determined by the MTT assay (n = 3).

19440035 27086926
ELISA
IGF2; 

PubMed: 27086926     


Determination of vorinostat-induced IGF2 production by ELISA (n = 3). The conditioned mediums (CMs) obtained from cells treated with vorinostat (5 μM) for 2 days were used for ELISA. 

IL-13/IL-10/IL-5; 

PubMed: 18541724     


Effect of vorinostat on TH1/TH2 cytokine secretion in HL cell lines. Cells were incubated with medium or vorinostat (5 μM) for 24 hours and supernatants were examined for cytokine levels by ELISA. Each value represents a mean of 3 independent experiments done in triplicate (± SEM).

M-CSF; 

PubMed: 23042302     


Primary PyMT tumor cells were treated with SAHA (0-1000nM) for varying time points (8–48h), and supernatants were assayed by ELISA for M-CSF  secretion. *P < 0.05 and **P < 0.001 versus control treatment. 

MMP-9; 

PubMed: 23042302     


Primary PyMT tumor cells were treated with SAHA (0-1000nM) for varying time points (8–48h), and supernatants were assayed by ELISA for MMP-9 secretion. *P < 0.05 and **P < 0.001 versus control treatment. 

27086926 18541724 23042302
体内研究 Decitabine和Vorinostat都具有使肿瘤衰退的功能。然而, Decitabine 和 Vorinostat 联用使肿瘤衰退的效果更强。没有任何处理时,在野生型和Fasgld 小鼠中在肺肿瘤负担方面观察不到明显的区别。然而, Decitabine 和Vorinostat联用处理野生型小鼠,使肿瘤衰退比处理 Fasgld小鼠效果高很多。 Decitabine和Vorinostat使结肠癌细胞对FasL调节的肿瘤衰退敏感。低剂量Decitabine和Vorinostat处理,没有明显的肝脏毒性。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[4]
+ 展开

组蛋白去乙酰化酶活性测定:

为了进行 HDAC 实验24 × 104 dpm 乙醇溶液(1 mCi/ml)中提供的sup>3H-醋酸钠盐标记的组蛋白H4等份样, 加到每个试管中,试管中含悬浮在25 µL实验buffer(100 mM Tris-HCl pH 8, 2mM EDTA)中的200 µg全部HeLa细胞裂解液进行免疫沉淀获得的HDAC。加入不同浓度Vorinostat,在30oC下温育90分钟。加入20 µL 终止缓冲液(0.5 N HCl, 0.08 M AcOH)终止反应。加入0.8 mL TBME提取释放放入氚醋酸盐。在8,000 × g 转速下离心5分钟,600 µL 有机相(上相) 转移到包含3 mL闪烁液的闪烁瓶中。
细胞实验:[4]
+ 展开
  • Cell lines: NB4, NCI-H460和HCT-116肿瘤细胞系
  • Concentrations: 0 μM - 0.1 μM
  • Incubation Time: 48小时
  • Method: NB4, NCI-H460和HCT-116肿瘤细胞系生长在200 µL 96孔板中,约10%汇合,生长24小时后,覆盖孔中。使用多种浓度 Vorinostat或溶剂处理肿瘤细胞24小时。处理后,冲洗实验板,移除Vorinostat,温育48小时。使用sulphorodamine B 实验测定Vorinostat处理后存活细胞的分数。
    (Only for Reference)
动物实验:[3]
+ 展开
  • Animal Models: 携带CT26 细胞的Fasgld BALB/cByJ小鼠
  • Formulation: Dissolved in DMSO
  • Dosages: 25 mg/kg
  • Administration: 静脉注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 52 mg/mL (196.74 mM)
Ethanol 3 mg/mL (11.35 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
5mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 264.3
化学式

C14H20N2O3

CAS号 149647-78-9
稳定性 powder
in solvent
别名 SAHA, MK0683, suberoylanilide hydroxamic acid

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2