Vorinostat (SAHA)

For research use only. Not for use in humans.

目录号:S1047 别名: MK0683 中文名称:伏立诺他

Vorinostat (SAHA) Chemical Structure

CAS No. 149647-78-9

Vorinostat (suberoylanilide hydroxamic acid, SAHA, MK0683)是一种HDAC抑制剂,无细胞试验中IC50为~10 nM。Vorinostat 会抑制高效的HPV-18 DNA扩增。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1558.77 现货
RMB 1198.15 现货
RMB 1794.86 现货
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客户使用Selleck生产的Vorinostat (SAHA)发表文献396篇:

产品安全说明书

HDAC抑制剂选择性比较

生物活性

产品描述 Vorinostat (suberoylanilide hydroxamic acid, SAHA, MK0683)是一种HDAC抑制剂,无细胞试验中IC50为~10 nM。Vorinostat 会抑制高效的HPV-18 DNA扩增。
特性 Vorinostat是广谱HDAC活性抑制剂,抑制I和II类酶 。
靶点
HDAC [1]
(Cell-free assay)
~10 nM
体外研究

Vorinostat是小分子量(<300)线性肟酸,抑制HDAC活性,包括乙酰化组蛋白和非组蛋白的积累,抑制培养细胞的增殖,且抑制肿瘤生长。Vorinostat通过结合到酶的活性位点而抑制 HDAC活性。Vorinostat 抑制多种转化细胞增殖(包括 淋巴瘤,多发性骨髓瘤,白血病,和非小细胞肺癌),与对照组相比抑制生长达50% 时的浓度为0.5 到10μM。Vorinostat作用于淋巴瘤和白血病细胞,包括 Burkitt, B-细胞急性淋巴细胞白血病 (B-ALL), MCL, DLBCL, ATL和T-细胞,不同程度抑制细胞增殖。除了抑制转化细胞增殖, Vorinostat 也抑制正常细胞增殖,通过比较Vorinostat 作用于一组细胞系–正常人非纤维细胞(WI-38)和 SV40巨大T抗原转化WI-38(VA-13细胞)而得到证明。Vorinostat 抑制两种类型细胞增殖,这种作用存在剂量依赖性。但发现Vorinostat 对转化细胞具有选择毒性,包括使肿瘤细胞死亡,而对正常细胞只起抑制作用,不会使其死亡。[1] Genistein 和Vorinostat 联用效果比5-aza和Vorinostat 联用作用于诱导细胞死亡有效很多。Genistein和Vorinostat联用作用于ARCaP-E使增殖降低 80 %,作用于ARCaP-M细胞,增殖降低60 %以上。Genistein和Vorinostat 联用抑制细胞增殖具有协同效应。作用于ARCaP-E 细胞(820个基因 诱导和1046个基因抑制) ARCaP-M 细胞,Vorinostat比Genistein 影响更多基因。[2] Vorinostat作用于肿瘤细胞表面,提高Fas蛋白水平,这种作用存在剂量依赖性,且按0.75 μM剂量处理,提高达到一个稳定水平。[3] Vorinostat 抑制肿瘤细胞生长,包括NB4, H460 和HCT-116,IC50分别为0.7μM, 3.4μM和1.2 μM。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
H1299 MUHLbY5ie2ViQYPzZZk> MofTNlAhdWmw NXLBWWF3TE2VTx?= NV3TOpF{UW6qaXLpeI9zgSCjY4Tpeol1gSCjZ3HpcpN1KEiGQVOg[Y57gW2nIIfpeIghUUN3MDDv[kAxNjF7NDFOwG0> NYDMUllRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUS1NlE1OjJpPkG0OVIyPDJ{PD;hQi=>
HT1080 NEXXR41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPpUWg4OiCq M3GxemROW09? M2Lwb2lEPTB;Mj60JO69VQ>? MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjJ5MEG3OUc,OTJ{N{CxO|U9N2F-
K562 NGDSPZJMcW6jc3WgRZN{[Xl? MnXLOkBp M1jwPGROW09? NFXQfnlKdmirYnn0bY9vKG:oIHj1cYFvKGirc4TvcoUh\GWjY3X0fYxie2ViKH3pfJR2emVib3[gTGRCSzFiYX7kJGhFSUN{KTD3bZRpKEmFNUCgc4YhOC5yMTFOwG0> MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjRzOUO4NEc,OTJ2MUmzPFA9N2F-
A20 NInYfVNMcW6jc3WgRZN{[Xl? NHLsfmMyKGh? M3fPRWROW09? MkD4ZY51cS2KRFHDNUBi[3Srdnn0fUB4cXSqIFnDOVAhd2ZiMD6xNVIh|ryP MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTl4MES4PUc,OTF7NkC0PFk9N2F-
Friend leukemic cell M3nwR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWe2bW45PTBizszN MoTLO|IhcA>? NHzMbWxFVVOR MWXJR|UxRTBwOUmg{txO NEKyUY09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkGwPVkyOyd-MUKxNFk6OTN:L3G+
H1299 MlHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfXTlA4OiCq MlLRSG1UVw>? M{TtdWlEPTB;Nz6yOEDPxE1? M2SySlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF2NUKxOFIzLz5zNEWyNVQzOjxxYU6=
HeLa NUXvelluU2mwYYPlJGF{e2G7 MV2zNEBucW5? NHj3c4pKdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gZYdicW6|dDDobZN1d26nIHTlZYNmfHmuYYPlJJdqfGhiSVO1NEBw\iByLkK4JO69VQ>? M4jqN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NkCzPVQ6Lz5zNU[wN|k1QTxxYU6=
LOX-IMVI MlnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTkWI97PDhiaB?= MkDrTWM2OD1zLkOg{txO M3XQUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3N{G1OFcxLz5zNUexOVQ4ODxxYU6=
NCI-H226 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvMV|Y1QCCq NXG0SHM1UUN3ME2yMlYh|ryP MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTdzNUS3NEc,OTV5MUW0O|A9N2F-
RXF-631L Mn\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWW0PEBp MWjJR|UxRTJizszN M13RelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3N{G1OFcxLz5zNUexOVQ4ODxxYU6=
SNB-78 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYG0PEBp M{\uc2lEPTB;MU[g{txO MoPDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV5MUW0O|AoRjF3N{G1OFcxRC:jPh?=
St-4 NHvQVW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LCNVQ5KGh? NWO2bndqUUN3ME21MlIh|ryP NUjzbWdQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW3NVU1PzBpPkG1O|E2PDdyPD;hQi=>
ARP1 NHrvTY5HfW6ldHnvckBCe3OjeR?= NXz0V2J4OiEQvF2= MWm2JIg> Mlz2TY5lfWO2aX;uJI9nKFB{MWfBSlEh\2WwZTDlfJBz\XO|aX;u NEn0Z2M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNEezOFgxPid-MUS3N|Q5ODZ:L3G+
CEM MWnLbY5ie2ViQYPzZZk> MnvxNUBp M4joXmROW09? MUDJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwM{Og{txO NWe3ZnNJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[0NlAxPjRpPkG2OFIxODZ2PD;hQi=>
HCT15 NYLrNZlYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TjdlQ5KGh? NX3LWotrT0l3ME2wMlgzKM7:TR?= NUTjT3lbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[3NlMzOjdpPkG2O|I{OjJ5PD;hQi=>
NCI-H23 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnSeI5sPDhiaB?= MU\HTVUxRTBwOUKg{txO NVXuNHdQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[3NlMzOjdpPkG2O|I{OjJ5PD;hQi=>
GM15850 NFPtUZhMcW6jc3WgRZN{[Xl? MkXvNk42KM7:TR?= MYW5OkBp NXTk[4dtTE2VTx?= MorNTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSEOgcJl{cW6nIEG0JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n NGLobYc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkmyNVM3Pyd-MU[5NlE{Pjd:L3G+
GM15850 M1G2SmtqdmG|ZTDBd5NigQ>? MUmyMlUh|ryP MmXVPVYhcA>? NH3RbWVFVVOR NWjTblFUUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFUh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NILEPG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkmyNVM3Pyd-MU[5NlE{Pjd:L3G+
GM15850 NF\QVXVMcW6jc3WgRZN{[Xl? M3PycFIvPSEQvF2= MlPmPVYhcA>? NHTpdFRFVVOR MonCTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEGyJIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n MkT1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ7MkGzOlcoRjF4OUKxN|Y4RC:jPh?=
GM15850 NFPHU49McW6jc3WgRZN{[Xl? MYeyMlUh|ryP MYG5OkBp MX7EUXNQ NVjjVXdKUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFkh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NH;RUnk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkmyNVM3Pyd-MU[5NlE{Pjd:L3G+
GM15850 NYXnUoV1U2mwYYPlJGF{e2G7 MV[yMlUh|ryP NX;ZXZhxQTZiaB?= NIDGXnFFVVOR M4TuOmlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTC4JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n NVfCNnE{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[5NlE{PjdpPkG2PVIyOzZ5PD;hQi=>
GM15850 MV7LbY5ie2ViQYPzZZk> MUeyMlUh|ryP Mom1PVYhcA>? NHHrdo1FVVOR MULJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKNDDsfZNqdmViMU[gZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? Mn\rQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ7MkGzOlcoRjF4OUKxN|Y4RC:jPh?=
U937 M{S4WmZ2dmO2aX;uJGF{e2G7 NWTvSYZOPSEQvF2= NILIWYwzPCCq MULEUXNQ MkfGR4VtdCCleXPs[UBienKnc4SgZpkh[WOldX31cIF1cW:wIHH0JHMwTzJxTTDwbIF{\Q>? M2P0XVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MEC0O|E5Lz5zN{CwOFcyQDxxYU6=
H661 M3P4U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjQSJo1QCCq NYXBboh4UUN3ME2xJO69VQ>? NGDYdpk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G1O|AxQSd-MUexOVcxODl:L3G+
U937 Mmi4SpVv[3Srb36gRZN{[Xl? NHzQUms2KM7:TR?= M4faOFI1KGh? Mn;DSG1UVw>? NXXsZ25GUW6lcnXhd4UhcW5iaHnzeI9v\SCKMzDhZ4V1gWyjdHnvci=> NWD6UI1IRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0OFc4PTBpPkG3OFQ4PzVyPD;hQi=>
U937 M4ToWmZ2dmO2aX;uJGF{e2G7 NIewNW8yKM7:TR?= Mn;hNlQhcA>? NHHKbXFFVVOR MXTF[oZm[3Rib36gZYxxcGFidIXieYxqdiCjY3X0fYxifGmxbh?= NE\KWVA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{S0O|c2OCd-MUe0OFc4PTB:L3G+
RAW264.7 Moq5SpVv[3Srb36gRZN{[Xl? M{C2dFExKM7:TR?= MnvrNlRp NEHkclZ4[XSnch?= MnnpTY5pcWKrdHnvckBw\iCOUGOtd5RqdXWuYYTl[EBVVk[jbIDoZUBxem:mdXP0bY9vKHerdHigTWM2OCCxZjCwMlc3KM7:TR?= NF\aeGQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{S3O|UyQCd-MUe0O|c2OTh:L3G+
RAW264.7 M2PRUGZ2dmO2aX;uJGF{e2G7 M2P2fFExKM7:TR?= MoD5NlRp NXjRbXZ1f2G2ZYK= M{XCVWlvcGmkaYTpc44hd2ZiTGDTMZN1cW23bHH0[YQhVk9icILv[JVkfGmxbjD3bZRpKEmFNUCgc4YhOS56ODFOwG0> NE\FWms9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{S3O|UyQCd-MUe0O|c2OTh:L3G+
SC9 M3Lp[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXO0PEBp MVTJR|UxRTBwNkC2JO69VQ>? MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzVyN{KxPUc,OTd3MEeyNVk9N2F-
ST14A Mn;mSpVv[3Srb36gRZN{[Xl? MV61JI5O MVW3NkBp MXHJcoNz\WG|ZTDpckBTTVOWL17SV2YhdVKQQTDlfJBz\XO|aX;u MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzV4NUm5N{c,OTd3NkW5PVM9N2F-
ST14A NX\UN5N4TnWwY4Tpc44hSXO|YYm= NHvE[pg2KG6P NVOxephxPzJiaB?= MXPJcoNz\WG|ZTDpckBGOkZzIH3SUmEh\XiycnXzd4lwdg>? NYDFXXFXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1OlU6QTNpPkG3OVY2QTl|PD;hQi=>
PANC1 MkPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofwNUDPxE1? MoTwTWM2OD1yLkS1JO69VQ>? NHLPbnk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{W4PFc1PCd-MUe1PFg4PDR:L3G+
PANC1 NW\1bZpPTnWwY4Tpc44hSXO|YYm= NFThdWcyKM7:TR?= NX;KUnJlOjRiaB?= M4WwVWlv[3KnYYPlJIlvKHB{MWfBSlEwS0mSMTDn[Y5mKGW6cILld5Nqd25? MojPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3OEi3OFQoRjF5NUi4O|Q1RC:jPh?=
PANC1 MlXVSpVv[3Srb36gRZN{[Xl? MXuxJO69VQ>? MmDlNlQhcA>? NXf1OZRTUW6lcnXhd4UhcW5icEK3b4lxOSCpZX7lJIV5eHKnc4Ppc44> NX7ETmI5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1PFg4PDRpPkG3OVg5PzR2PD;hQi=>
PT45 MmLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTWPZROUUN3ME20JO69VQ>? MkDNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3OEi3OFQoRjF5NUi4O|Q1RC:jPh?=
ACHN M4f6RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjV[mF7OjFiaB?= NWmzNohST0l3ME2wMlY2KM7:TR?= NE\wR5g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[2NlYxPid-MUe2OlI3ODZ:L3G+
PC3 M13DSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnZeIR5OjFiaB?= M2nlOWdKPTB;MD63NUDPxE1? Mo\kQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4NkK2NFYoRjF5Nk[yOlA3RC:jPh?=
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HepG2 NWrIToNCU2mwYYPlJGF{e2G7 NHrF[Go2KM7:TR?= MXi2bC=> M3;HUmROW09? NFj1RY1KdmS3Y4Tpc44hd2ZiSFTBR{1u\WSrYYTl[EBJOy:KNDDobZN1d26nIHHj[ZR6dGG2aX;u MlXzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzNEO4OFAoRjJyMUSzPFQxRC:jPh?=
COLO205 M371WWtqdmG|ZTDBd5NigQ>? NV3icHNPOTBizszN MYeyOEBp M2X0UGROW09? NUO5RZVJUW6qaXLpeIlwdiCxZjDISGFEOSCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4YhcGm|dH;u[UBJOyCjY3X0fYxifGmxbjD3bZRpKEmFNUCgc4YhOi5{IN88US=> NH3CSog9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MES1NVM4QCd-MkC0OVE{Pzh:L3G+
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NB4 M2rjW2Z2dmO2aX;uJGF{e2G7 Ml\mOUDPxE1? NXrocVhUOjRiaB?= NXHSTVZkTE2VTx?= NHL4Z5VE\WyuIHP5Z4xmKGG{cnXzeEBie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDhZ4N2dXWuYYTpc44h[XRicILlMWcyKHCqYYPl M3PTXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNEmxOFQxLz5{MES5NVQ1ODxxYU6=
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NB4 NIXy[opMcW6jc3WgRZN{[Xl? NVTWXlBtPSEQvF2= MXWyOEBp MYHEUXNQ M3:zN2lvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFizJIFk\XS7bHH0bY9v MkLIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB2OUG0OFAoRjJyNEmxOFQxRC:jPh?=
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A549 MVvGeY5kfGmxbjDBd5NigQ>? Mn7COUDPxE1? NYHGeWtxOyCq Mn\4SG1UVw>? NH7rVphKdmS3Y4Tpc44hd2ZiYYX0c5Bp[We7IHnuJIh2dWGwIFG1OFkh[2WubIOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iTFOzTWk> NVWzRlVHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4OVUzODhpPkKwPFU2OjB6PD;hQi=>
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A431 MmGwR5l1d3SxeHnjJGF{e2G7 Mn3QO|IhcA>? MV;DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOFMyKGOnbHzzJI93\XKneIDy[ZN{cW6pIFXHSnIhf2m2aDDJR|UxKG:oIESuNkDPxE1? M1i2flxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMEiwOlI6Lz5{MUC4NFYzQTxxYU6=
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CAL27 MUXDfZRwfG:6aXOgRZN{[Xl? M3q5OlczKGh? NUf3NJJuS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hS0GOMkegZ4VtdHNib4\ldoV5eHKnc4PpcochTUeIUjD3bZRpKEmFNUCgc4YhOy5{IN88US=> NF\Rd5o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUC4NFYzQSd-MkGwPFA3Ojl:L3G+
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SKOV3 M1:2XmN6fG:2b4jpZ{BCe3OjeR?= NFX4RYk4OiCq Mn3LR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2tQXjNiY3XscJMhd3[ncnX4dJJme3OrbnegTGVTOiC5aYToJGlEPTBib3[gNk4zKM7:TR?= MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB6ME[yPUc,OjFyOEC2Nlk9N2F-
COR-L23 MlGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITocnoyOCEQvF2= NX;NN2lkPzJiaB?= MWXEUXNQ M2TXNWdKPTB;MT6xJO69VQ>? NUnoZ4M2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGwPFA3PDdpPkKxNFgxPjR5PD;hQi=>
DU145 NFTGRVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\1NVAh|ryP MmraO|IhcA>? MWLEUXNQ MofGS2k2OD1zLkC1JO69VQ>? MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB6ME[0O{c,OjFyOEC2OFc9N2F-
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MCR5-SV2 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rPOVExKM7:TR?= NHnze3E4OiCq M4LyNGROW09? NYT4cJlWT0l3ME2yMlEh|ryP NGTIUFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUC4NFY1Pyd-MkGwPFA3PDd:L3G+
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HCT116 MmLMT4lv[XOnIFHzd4F6 M1[5UVMxKM7:TR?= MmnvN|AhcA>? Mn\WSG1UVw>? NEnvSpFKdmirYnn0bY9vKG:oIFjERWMyKGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBpcXO2b37lJGg{UzliYXPleJlt[XSrb36= NVrvN2VDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGwPFA3PDdpPkKxNFgxPjR5PD;hQi=>
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U937 M3y3XGtqdmG|ZTDBd5NigQ>? MmnEOUDPxE1? NGKw[VEyPSCvaX6= Moi3SG1UVw>? MnHOTY5pcWKrdHnvckBw\iCqaYP0c45mKGGlZYT5cJRz[W6|ZnXyZZNmKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIH;mJIhqe3SxbnWgTFMh[WOndInsZZRqd25ibHX2[Yw> NWP4Z|J[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGyPVI1QTJpPkKxNlkzPDl{PD;hQi=>
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COLO205 NGTjU2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV[5OkBp NEDoSFVFVVOR MnP6TWM2OD1{LkGyJO69VQ>? MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTZ|NESzNEc,OjF4M{S0N|A9N2F-
Hep3B MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnOOJBQPDhiaB?= MkHNSG1UVw>? MoDiS2k2OD1zLkKxJO69VQ>? NY\tfWxuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG3NVIyPDZpPkKxO|EzOTR4PD;hQi=>
GM11272 MoqwSpVv[3Srb36gRZN{[Xl? MYGxNFAhdk1? NUfUXlg2PzJiaB?= NHTUS|ZFVVOR NVy0TVV2WmWjY4TpeoF1cW:wIH;mJG1mS3B{IH31eIFvfCCneIDy[ZN{cW:wIHH0JFExKHSxIEGwNEBvVQ>? MoXpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6NEC3NVYoRjJzOESwO|E3RC:jPh?=
CFBE41o M3HLVmtqdmG|ZTDBd5NigQ>? MmC1OUDPxE1? MmLpSG1UVw>? M{C3dGRwf25icnXneYxifGmxbjDv[kBJTEGFNzDheEAxNjJidH:gOUB2VQ>? MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl6NEm1PEc,OjF7OES5OVg9N2F-
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A549/ATCC NU\ifY45T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TRd|YvOiEQvF2= MUm3NkBp M2jFfGROW09? MnGxS2k2OD1zLk[g{txO MmfsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2M{W2OlkoRjJ{NEO1OlY6RC:jPh?=
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IGROV1 NGXmU|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjyOk4zKM7:TR?= NX;oWJRJPzJiaB?= NVi0TZk6TE2VTx?= Mm\iS2k2OD1zLkOg{txO MnTNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2M{W2OlkoRjJ{NEO1OlY6RC:jPh?=
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M14 NHjU[FBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYO2MlIh|ryP NX;UNpU{PzJiaB?= M1\2S2ROW09? NXfnOHd2T0l3ME2xMlMh|ryP NFHqclk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSzOVY3QSd-MkK0N|U3Pjl:L3G+
MALME-3M NEXMfHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3yzfVYvOiEQvF2= M4LOXFczKGh? M3:5eGROW09? NF:zSJdIUTVyPUCuN|Ih|ryP NWPUbJpiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0N|U3PjlpPkKyOFM2PjZ7PD;hQi=>
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MDA-MB-435 MojoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\M[FYvOiEQvF2= M2n2blczKGh? NYPCU2RTTE2VTx?= NXHIb2ZrT0l3ME2wMlUh|ryP NVTudXBHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0N|U3PjlpPkKyOFM2PjZ7PD;hQi=>
MDA-MB-468 NWLmOW1QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\JOk4zKM7:TR?= M4XqWlczKGh? NI\UXIhFVVOR M3SyTGdKPTB;MD62N{DPxE1? NWr2b|FvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0N|U3PjlpPkKyOFM2PjZ7PD;hQi=>
MOLT4 NHizfoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUC2MlIh|ryP NX73b|h5PzJiaB?= MX\EUXNQ MXnHTVUxRTBwNDFOwG0> NYTyfnJGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0N|U3PjlpPkKyOFM2PjZ7PD;hQi=>
NCI-ADR-RES MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PMb|YvOiEQvF2= MV23NkBp MVvEUXNQ M4XvfGdKPTB;MD6xOkDPxE1? M4nqZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEO1OlY6Lz5{MkSzOVY3QTxxYU6=
NCI-H23 M3;6Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkW4Ok4zKM7:TR?= NEnwXm44OiCq MYXEUXNQ NH7XXopIUTVyPUGg{txO NUXaVpJXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0N|U3PjlpPkKyOFM2PjZ7PD;hQi=>
NCI-H322M NYTzfVVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXi2MlIh|ryP MnXjO|IhcA>? MnPKSG1UVw>? MkDGS2k2OD1yLke5JO69VQ>? M1K5NFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEO1OlY6Lz5{MkSzOVY3QTxxYU6=
NCI-H460 NGHjWGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfCe5g3NjJizszN Mk\rO|IhcA>? M3S0cGROW09? MYLHTVUxRTBwN{mg{txO NUDwcoluRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0N|U3PjlpPkKyOFM2PjZ7PD;hQi=>
NCI-H522 M1XR[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\yO4VPPi5{IN88US=> Mny3O|IhcA>? M2\0NGROW09? MoHMS2k2OD1yLkWg{txO NGTMbGs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSzOVY3QSd-MkK0N|U3Pjl:L3G+
OVCAR3 NXvyc|J6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfabldLPi5{IN88US=> NE\pWYY4OiCq NXTIVVZnTE2VTx?= NF3SbotIUTVyPUGuN{DPxE1? NFiwTo09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSzOVY3QSd-MkK0N|U3Pjl:L3G+
OVCAR4 NEn6SnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4O0PVYvOiEQvF2= Mn7QO|IhcA>? NIDYSmRFVVOR MWnHTVUxRTRizszN MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR|NU[2PUc,OjJ2M{W2Olk9N2F-
OVCAR5 M1O4W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUW2MlIh|ryP M1XXXVczKGh? MmfQSG1UVw>? M2rNTmdKPTB;MD63PUDPxE1? NYnTTZBJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0N|U3PjlpPkKyOFM2PjZ7PD;hQi=>
OVCAR8 NIrzV5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7rWYI3NjJizszN M{DoeVczKGh? NHjSWXlFVVOR MmOyS2k2OD1yLkWg{txO NYW1dGZFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0N|U3PjlpPkKyOFM2PjZ7PD;hQi=>
RXF393 NGPpUWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHQOk4zKM7:TR?= MlvxO|IhcA>? NF74VnZFVVOR NEPiOZBIUTVyPUGuN{DPxE1? MnWxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2M{W2OlkoRjJ{NEO1OlY6RC:jPh?=
SF268 NX3VXIxQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HEUFYvOiEQvF2= MVi3NkBp NFXtTVdFVVOR MXPHTVUxRTFwNjFOwG0> NVSyfJZXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0N|U3PjlpPkKyOFM2PjZ7PD;hQi=>
SF295 M3ewe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\LclYvOiEQvF2= M1\IRVczKGh? NGDjfHZFVVOR M4Lu[WdKPTB;MT62JO69VQ>? NV;rcpFrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0N|U3PjlpPkKyOFM2PjZ7PD;hQi=>
SF539 NFK5XpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rCPVYvOiEQvF2= NWizeYhNPzJiaB?= MVvEUXNQ MV\HTVUxRTJizszN MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR|NU[2PUc,OjJ2M{W2Olk9N2F-
SK-MEL-2 NEW1UVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYS2MlIh|ryP MXi3NkBp Mnj1SG1UVw>? Mkn5S2k2OD1zLkOg{txO NFnjfGs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSzOVY3QSd-MkK0N|U3Pjl:L3G+
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Hep3B Mn7CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnntOFghcA>? NH\NW3hFVVOR M1jhbmdKPTB;MD62PUDPxE1? MmPjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2M{m4OlMoRjJ{NEO5PFY{RC:jPh?=
BE(2)-C M{e2PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX63NkBp NEf5bnNFVVOR M37RdGlEPzB;MjFOwG0> NWjaWXVERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK5N|I{OTZpPkKyPVMzOzF4PD;hQi=>
Bel7402 NXuwUGdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHtO|IhcA>? NIf5dlVFVVOR NVW1OGJ3T0l7ME2xO{DPxE1? MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB4MUO3Okc,OjNyNkGzO|Y9N2F-
Bel7404 NWm3N3BqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjnO|IhcA>? NV6zVldGTE2VTx?= Mmn6S2k6OD1zODFOwG0> NVzjdpZGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwOlE{PzZpPkKzNFYyOzd4PD;hQi=>
BGC823 NX36V5hvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DBbFczKGh? M2LVWmROW09? NXLNfmJCT0l7ME23MlUh|ryP MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB4MUO3Okc,OjNyNkGzO|Y9N2F-
MGC803 NYDZeohkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY[3NkBp MXHEUXNQ NYnaToVmT0l7ME2xNE45KM7:TR?= MkjPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyNkGzO|YoRjJ|ME[xN|c3RC:jPh?=
SGC7901 M{jYXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkC2O|IhcA>? NVfQdGp[TE2VTx?= NWDCdYNDT0l7ME25MlQh|ryP MnrGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyNkGzO|YoRjJ|ME[xN|c3RC:jPh?=
SKHEP1 NEDlOoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUK3NkBp MV7EUXNQ NVSxSJR1T0l7ME2xO{DPxE1? MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB4MUO3Okc,OjNyNkGzO|Y9N2F-
SMMC7721 MmW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3oO|IhcA>? M{DnOWROW09? MWfHTVkxRTJyIN88US=> M2HDPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|ME[xN|c3Lz5{M{C2NVM4PjxxYU6=
NUGC3 M{L0Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvzNWgyOCEQvF2= MnLPS2k:Oi57NDFOwG0> NVy2OYJ4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOxOlM{OzJpPkKzNVY{OzN{PD;hQi=>
A2780 CisR MojQT4lv[XOnIFHzd4F6 NInpNFgyQCCq M1\6U2lvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD60OEDPxE1? MkO1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{NUK2NFMoRjJ|MkWyOlA{RC:jPh?=
CAL27 sens MnjDT4lv[XOnIFHzd4F6 Mn3NNVghcA>? M2PidGlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD6zOkDPxE1? NHKzdJY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{K1NlYxOyd-MkOyOVI3ODN:L3G+
CAL27 CisR MV3LbY5ie2ViQYPzZZk> M3vzWlE5KGh? MYjJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNkGg{txO NHHtXGI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{K1NlYxOyd-MkOyOVI3ODN:L3G+
KYSE-510 CisR M{PVVmtqdmG|ZTDBd5NigQ>? M1XJRlE5KGh? MV\Jcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNUmg{txO M{LHZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MkWyOlA{Lz5{M{K1NlYxOzxxYU6=
KYSE-510 sens NVjRWplTU2mwYYPlJGF{e2G7 NX[1bGxrOThiaB?= NGjsb5NKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuO{DPxE1? NWXRVYRNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyOVI3ODNpPkKzNlUzPjB|PD;hQi=>
MDA-MB-231 sens NHXPe2tMcW6jc3WgRZN{[Xl? M1L0NlE5KGh? NGniSlNKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOlEh|ryP NHnCNI49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{K1NlYxOyd-MkOyOVI3ODN:L3G+
MDA-MB-231 CisR M1zlcmtqdmG|ZTDBd5NigQ>? MX6xPEBp MWLJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNkGg{txO MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ3Mk[wN{c,OjN{NUK2NFM9N2F-
ES2 M1z5TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUm0PEBp NVy4WXhsTE2VTx?= MlK5TWM2OD1zMj63JO69VQ>? NEDBTVg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S5N|Q1QSd-MkO0PVM1PDl:L3G+
MDA-MB-231 M1jzcGtqdmG|ZTDBd5NigQ>? MlWxNVAh|ryP MVGzNEBucW5? M3;2V2ROW09? NEXEdJJKdmirYnn0bY9vKG:oIFjERWMz[Q>? M3nnelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NEmzOFQ6Lz5{M{S5N|Q1QTxxYU6=
MDA-MB-231 NXrVWo1qU2mwYYPlJGF{e2G7 M{H0fFEh|ryP NHn6SWUzPCCq NVr0WYlETE2VTx?= NFvB[oxKdmirYnn0bY9vKG:oIFjERWM3KGG|c3Xzd4VlKGG|IHHj[ZR6dGG2aX;uJIxmfmWuczDv[kB1fWK3bHnu NV;ab2FIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0PVM1PDlpPkKzOFk{PDR7PD;hQi=>
HS68 MU\DfZRwfG:6aXOgRZN{[Xl? M3POOFExKM7:TR?= NXWxc3JXPzJiaB?= M3HneGROW09? NHXGSY9KSzVyPUSuOkDPxE1? NGrwSVU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{W3NFU1Oid-MkO1O|A2PDJ:L3G+
MEF M{G5OGN6fG:2b4jpZ{BCe3OjeR?= MX[xNEDPxE1? NU\NUJJCPzJiaB?= NGrlXXFFVVOR MUDJR|UxRTRwNDFOwG0> NV7xU3d[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1O|A2PDJpPkKzOVcxPTR{PD;hQi=>
BGC823 M2PtOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVu5SoRuTE2VTx?= M{HiVWdKPTB;Mz6wPUDPxE1? NHXSe2k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[wNVcxPid-MkO2NFE4ODZ:L3G+
High5 NVLJRZJ{U2mwYYPlJGF{e2G7 MUGyOEBp NHS2fHNKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjERWM3KHerdHigTWM2OCCxZjCwMlA6KM7:TR?= MnK1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MEK1NlMoRjJ|NkCyOVI{RC:jPh?=
High5 NXPiOY9tU2mwYYPlJGF{e2G7 NFfyUnkzPCCq MUnJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEiGQVOxJJdqfGhiSVO1NEBw\iByLkGyJO69VQ>? M3zKXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkCyOVI{Lz5{M{[wNlUzOzxxYU6=
High5 M3\LOGtqdmG|ZTDBd5NigQ>? MYeyOEBp MkC1TY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCKRFHDN{B4cXSqIFnDOVAhd2ZiMD6xO{DPxE1? NIDBb2M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[wNlUzOyd-MkO2NFI2OjN:L3G+
A549 M1jYOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDFPJduTE2VTx?= NIrpSotKSzVyPUGuNFc6KM7:TR?= M2PEVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkS0NlExLz5{M{[0OFIyODxxYU6=
HCT116 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrEUXNQ NX\QVIh6UUN3ME2wMlc2PyEQvF2= NVyy[WdIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2OFQzOTBpPkKzOlQ1OjFyPD;hQi=>
K562 NWjyXGNIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXL0bWc{TE2VTx?= NGSwTXBKSzVyPUCuOlQ2KM7:TR?= Ml3IQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4NESyNVAoRjJ|NkS0NlExRC:jPh?=
GBC-SD NW\ONIE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4m3T|Uh|ryP Mn3KO|IhcA>? NVLQSGlqTE2VTx?= NGizWmFKSzVyPUG0Mlgh|ryP NFP2Omw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{ewO|I3OCd-MkO3NFczPjB:L3G+
HGC27 M3TQOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13GSVUh|ryP NGDRNVk4OiCq MnzOSG1UVw>? NUj2cXl2UUN3ME21MlQh|ryP NYHpc|lnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO3NFczPjBpPkKzO|A4OjZyPD;hQi=>
HL60 MX7LbY5ie2ViQYPzZZk> M1\3OVUh|ryP MV:yOEBp NGDjRZNFVVOR NFX5c2FKdmirYnn0bY9vKG:oIFjERWM> NFHlRmU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{ewO|I3OCd-MkO3NFczPjB:L3G+
Vero Mm\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrvPZQ4OiCq M3zLTGROW09? NV3vWIw{UUN3ME2wMlkh|ryP M1zGW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|N{i2OFUzLz5{M{e4OlQ2OjxxYU6=
NCI60 MVvDfZRwfG:6aXOgRZN{[Xl? NEnpOWw1QCCq NUjuOHg1TE2VTx?= M3vjOWdKRTBwNUOg{txO MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDBzNUOyO{c,OjRyMUWzNlc9N2F-
SW620 MXrDfZRwfG:6aXOgRZN{[Xl? M{XGXVQ5KGh? MkjESG1UVw>? MX;HTV0xNjV2IN88US=> M2K0dVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEG1N|I4Lz5{NECxOVMzPzxxYU6=
U251 NWjnepNMS3m2b4TvfIlkKEG|c3H5 MmXtOFghcA>? MnfBSG1UVw>? MYDHTV0yNjV|IN88US=> MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDBzNUOyO{c,OjRyMUWzNlc9N2F-
KM12 NV\PfXZDS3m2b4TvfIlkKEG|c3H5 M4rLSFQ5KGh? NEjxcohFVVOR MljkS2k:OS56ODFOwG0> NGHXN2E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NECxOVMzPyd-MkSwNVU{Ojd:L3G+
Hs578T NXPBbo1JS3m2b4TvfIlkKEG|c3H5 MVS0PEBp MVjEUXNQ NVzie4p1T0l;ND64N{DPxE1? NUPsUXpNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwNVU{OjdpPkK0NFE2OzJ5PD;hQi=>
MDA-MB-231 NHy4bFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;EPVQ5KGh? MojwTWM2OD1yLkG2JO69VQ>? NXnUbHZkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwPVUxOTZpPkK0NFk2ODF4PD;hQi=>
MCF7 NX\rUHl3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmO2OFghcA>? M2mxemdKRTBwNEWg{txO MlPmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzMUm1OVUoRjJ2MUG5OVU2RC:jPh?=
MDA-MB-435 NF3QXYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nMU|Q5KGh? MmLFS2k:OC56ODFOwG0> M2n2PFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUG5OVU2Lz5{NEGxPVU2PTxxYU6=
AsPC1 NUnucpRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXezNEDPxE1? NVXkPJhVPDhiaB?= NGrJXZFFVVOR MorhTWM2OD1|Lk[2JO69VQ>? NGjmOGw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEG4OVM4QCd-MkSxPFU{Pzh:L3G+
Jurkat E6.1 MofTT4lv[XOnIFHzd4F6 NIrBe4IzKGh? MoDnSG1UVw>? MYTJcohq[mm2aX;uJI9nKEiGQVO0JJdqfGhiSVO1NEBw\iByLkC0JO69VQ>? M4LIVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2Mk[xPFYzLz5{NEK2NVg3OjxxYU6=
KG1 M3nCVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVy0PEBp NXPIeVFMUUN3ME2xMlE2KM7:TR?= NVfJe2RbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NlUxODNpPkK0OVI2ODB|PD;hQi=>
HEL MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MormOFghcA>? MmX3SG1UVw>? MWDJR|UxRTBwNEmg{txO NHfZUXU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[5OFA2PSd-MkS2PVQxPTV:L3G+
HSC3 NHXseWJEgXSxdH;4bYMhSXO|YYm= M1H6dlEzKGh? MnHOSG1UVw>? MVnJR|UxRTBwN{Gg{txO NFPuNWk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEe2OlU3OCd-MkS3OlY2PjB:L3G+
HT-29 M1njSmN6fG:2b4jpZ{BCe3OjeR?= NYHNSIUxOTJiaB?= NWW3OJpkTE2VTx?= MofiTWM2OD1yLkeyJO69VQ>? NWHtZ21WRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3OlY2PjBpPkK0O|Y3PTZyPD;hQi=>
KB MXvDfZRwfG:6aXOgRZN{[Xl? NH7wd2EyOiCq MlviSG1UVw>? MXLJR|UxRTBwN{Wg{txO MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd4NkW2NEc,OjR5Nk[1OlA9N2F-
H460 MkXuR5l1d3SxeHnjJGF{e2G7 M1TNTVEzKGh? MmC3SG1UVw>? M{DsWmlEPTB;MD64NkDPxE1? NXm1RnBCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3OlY2PjBpPkK0O|Y3PTZyPD;hQi=>
MONE1 Mn:zR5l1d3SxeHnjJGF{e2G7 NVHVR2ZnOTJiaB?= NH23R|VFVVOR M3SyT2lEPTB;MT6xPEDPxE1? NFzRVVY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEe2OlU3OCd-MkS3OlY2PjB:L3G+
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