Vorinostat (SAHA, MK0683)

目录号：S1047 别名： SAHA, MK0683, suberoylanilide hydroxamic acid

Vorinostat (SAHA, MK0683) Chemical Structure

Molecular Weight(MW): 264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA)是一种HDAC抑制剂，无细胞试验中IC50为~10 nM。

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客户购买Selleck的此次产品后发表的文献100篇：

客户使用该产品的20个实验数据：

  • Activity of vorinostat in Jurkat and Peer T-ALL cell lines in an MTT cell viability assay. Cells were treated with increasing drug concentrations for 72 h. The data are plotted as the mean % of DMSO-treated control cells against the corresponding drug concentration. The error bars are the standard error. For each drug and cell line, 3-4 independent experiments were performed with 6 replicates at each drug concentration.

    Nature 2011 471, 235-9. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Differential effects of HDAC inhibitors on histone and tubulin acetylation. Immunofluorescence analysis of histone H3 (K9ac/K14ac) and tubulin acetylation in HeLa cells treated for 4 h with vehicle, SAHA (10 μM), tacedinaline (50 μM), PCI-24781 (20 μM. (a) Mapping of histone acetylation in K562 cells treated with HDAC inhibitors by LC-MS/MS. Cells were treated with TSA (10 μM), SAHA (5 μM), PCI-24781 (2 μM), tacedinaline (50 μM) for 6 h. Histones were extracted from cells and acetylated peptides were quantified after isobaric tagging.

    Nat Biotechnol 2011 29, 255-265. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Western blot analysis of histone H3 acetylation in the spleen of untreated and vorinostat-treated hNF-E2 tg mice (n = 4 of each genotype).

    J Exp Med 2012 209, 35-50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA down-regulates c-FLIP expression and increases the sensitivity of CaP cells to undergo apoptosis in the presence of bicalutamide (A) Bar graph illustrating the sub-G0/G1 cell population in 22Rv1 (left panel) and LNCaP (right panel) cells in the absence and presence of 10μM bicalutamide, administered as a single agent or in ombination with increasing concentrations of the HDAC inhibitor, SAHA. (B) Immunoblots demonstrating the single agent activity of bicalutamide or SAHA, or effect upon their combined administration on the expression of c-FLIP and/or the processing of PARP. Equal protein loading was confirmed by GAPDH. (C) Bar graph illustrating the effect of bicalutamide and SAHA upon the induction of caspase-8 or caspase-3/7 activity in 22Rv1 cells (left panel) and LNCaP cells (right panel). (D) Immunoblots characterizing the impact of SAHA and/or bicalutamide upon the induction of PARP cleavage, in the absence or presence of the pan-caspase inhibitor, ZIETD. ZIETD was incubated with the cells for 12 h prior to the experiment. All data points shown in (A) and (C) represent the mean ± S.E.M. value, calculated from four independent experiments.

    Clin Cancer Res 2012 18, 3822-33. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Analyses of efficacy, potency and IC50 of HDAC inhibitors point toward HDACs 1–3 as relevant candidates for beta cell protection. Ranking and raw data on ITF drugs (Table 3) and commercial HDAC inhibitors (Table 4) underlying the heat maps of Fig. 1 (A and B). The HDAC inhibitor compounds were tested using a HDAC activity kit and recombinant proteins to determine IC50 values on each individual HDAC (right part of the table). Each drug was further tested using Real-Time Cell Analysis (RTCA) to score their maximal effective concentration (ECmax) as well as the corresponding rescue percentage of cytokine treated INS-1 cells. The drugs were ranked according to % rescue. * DMSO alone controls were included in each experiment, but not shown here. The results indicate that the highest concentrations of DMSO used here (1:1,000) were slightly potentiating the proliferation of the cells. The effects observed in this group of compounds were ascribed to the DMSO.?

    Diabetologia 2012 55, 2421-2431. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Suberoylanilide hydroxyamic acid (SAHA) preserves CFP (+) expression in mouse optic nerves (MONs) from older mice. (a) CFP (+) mitochondria were longer and thicker in MONs from 12-month-old Thy-1 CFP mice (inset; scale bar = 2 μm). Oxygen–glucose deprivation (OGD) consistently reduced CFP pixel intensity in 12-month-old MONs despite longer and brighter CFP ( +) mitochondria (yellow arrows). (b) Blockade of AMPA/kain ate receptors with NBQX (30 μM), or pan-Histone deacetylase (HDAC) inhibition with SAHA (5 μM), effectively preserved CFP pixel intensity during OGD. The preservation of CFP (+) mitochondria correlates with protection of the CAP area during OGD and profound recovery.

    J Neurochem 2012 123 Suppl 2, 108-15. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • D and E, Regression of IL-13Ra 2-negative pancreatic tumors treated with SAHA and/or IL-13-PE. Mice were treated daily with i.p. injection of SAHA (25 mg/kg) from day 4 after tumor implantation for two weeks followed by i.t. injection of IL-13-PE (100 μ g/kg) from day 5 for two weeks. F and G, Regression of IL-13Ra 2-posotive pancreatic tumors (HS766T and MIA-PaCa2) treated with SAHA and/or IL-13-PE. The schedule of treatment was similar as in panel D and E. Statistical significances are shown by *: P < 0.05,†: P < 0.001.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

    IL-13Rα2 expression is upregulated in pancreatic tumors but not in organs of mice after treatment with HDAC inhibi tor, SAHA. A, qRT-PCR of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. Tumors were harvested next day after IL-13-PE treatment and total RNA extracted. Data shown is ratio of human IL-13Rα2/β-actin expression and multiplied by 1000 for convenience. Bars , SD of triplicate determinations. B, qRT-PCR of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Tissues were harvested at the same time point as in panel A and total RNA extracted. Data shown is ratio of mouse IL-13Rα2/β-actin expression and multiplied by 100 for convenience. C, IHC of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. D, IHC of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Liver, brain, kidney, pancreas, lung and spleen were fixed for immunostaining of mouse IL-13Rα2 as visualized by Alexa555. Nucleus was counterstained by DAPI.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Proliferation o f HT29 and HCT116 cells after 48 h of butyrate or SAHA treatment. Proliferation measurements using the xCEL Ligence RTCA DP instrument (Roche) in cells treated with increasing doses of butyrate or SAHA, compared with control medium cells (0) (*P < 0.05). The mean ?SEM of three cell culture replicates is shown.

    Mol Carcinog 2012 52, 459-74. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA induces the down-regulation of cFLIP expression and promotes TRAIL-mediated activation of a mitochondrial-operated apoptotic pathway. a BT-474 cells were treated as indicated in Fig. 1 and the cells were then harvested to analyse caspase-8, Bid, caspase-9, caspase-3 and PARP expression, using GAPDH as the protein loading control. b BT-474 cells were treated with SAHA for 8 h at the doses indicated and subsequently, the cells were harvested and the apoptosis-related proteins were analysed in western blots as described in the "Materials and Methods". The results shown are representative of at least three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Treatment with SAHA sensitizes breast cancer cells to TRAILinduced apoptosis. BT-474 and MDA-MB-231 cells were incubated for 8 h with SAHA at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some of the cultures for an additional 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content as described in the "Materials and methods". The results show the mean and S.E.M. of three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA facilitates the Itch/AIP4-independent proteasomal degradation of cFLIP proteins in breast cancer cells. a BT-474 cells were treated with SAHA (5 μM) for 8 h in the presence or absence of the proteasome inhibitors MG132 or epoxomicin (at the doses indicated), and they were then harvested and the cFLIP content was analysed in western blots. b BT-474 cells were transfected with either the siRNA oligonucleotides targeting Itch/AIP4 or the non-targeting RNA oligonucleotide (scrambled) for 48 h as described in the "Materials and Methods". Subsequently, the cells were treated with SAHA (5 μM) for 8 h and then cFLIP and Itch/AIP4 expression was analysed in immunoblots

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • cFLIP down-regulation following SAHA treatment is responsible for the sensitization of breast cancer cells to TRAIL. a BT-474 cells were transfected with either different siRNAs directed against the cFLIP isoforms or the non-targeting RNA oligonucleotide (scrambled) as described in the "Materials and Methods". After 24 h, the cells were treated with TRAIL (500 ng/ml) for a further 15 h and apoptosis was then measured as the percentage of cells with subG1 DNA content. The results show the mean and S.E.M. of three independent experiments. To verify protein knockdown, cells were harvested 24 h after transfection and the cFLIP levels were assessed in immunoblots. b. BT-474 cells overexpressing Cflipl (pBABE-FLIPL) or control cells (pBABE) were treated with SAHA for 8 h at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some cultures for 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content and the results show the mean and range of two independent experiments. Western blots show the cFLIP levels after SAHA treatment in pBABE and pBABE-FLIPL cells.

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Vorinostat inhibits the tumor growth. NOD ⁄ SCID-B2m-/-mice were injected s.c. with 1×106 MyLa2059 cells into both flanks. When the mice had developed established palpable tumors treatment was initiated (day 1). The mice received either vehicle (black line) or 60 mg ⁄ kg vorinostat (grey line) i.p. five days a week. In total, there were four mice in the group receiving vehicle and three mice in the group receiving vorinostat. The length and width of the tumors were measured continuously until the experiment was terminated on day 20 post treatment initiation. The tumor volume was calculated using the formula V = (a×b2)/2, where a defines the length (mm) and b the width (mm) of the tumor. The histogram shows the average tumor volume per flank ± SEM. * denotes a significant difference (P < 0.05) in the average tumor volume per flank between mice treated with vehicle and vorinostat at the given time-point both by using a one-tailed two samples test with Welch, scorrection and a Mann-Whitney U test.

     

     

    Exp Dermatol 2010 19, 1096-1102. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Western blot of whole cell extracts demonstrates SAHA and NaB treatment result in increased levels of acetylated histone H3 compared to vehicle controls. (b) Light micrographs of HDACi/vehicle treated cultures illustrate the paucity of neurospheres in HDACi-treated cultures. (c) Quantitative analysis confirms SAHA and NaB inhibit the formation of neurospheres (diameter ≥ 50 μm) and increase the prevalence of small cell clusters (≥ 4 cell, diameter < 50 μm). (d) Flow cytometry using LIVE/DEAD cell stain confirms SAHA and NaB are minimally toxic compared to vehicle controls (n = 3). Scale bar = 100 μm.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    (a) EdU flow cytometry of live cell-gated adult mouse NSCs demonstrates SAHA (**p < 0.01) and NaB (***p < 0.001) significantly inhibit DNA synthesis. (b) Analysis of DNA content by flow cytometry reveals significant accumulation of adult mouse NSCs in G1phase of the cell cycle following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (c) Correspondingly the proportion of cells in G2/M phase is significantly reduced following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (d) Fluorescence micrographs of HDACi/vehicle treated adult NSCs pulse-labeled with EdU for flow cytometry. Scale bar = 50 μm. Statistical comparisons performed using one-way ANOVA with post hoc Newman-Keuls multiple comparison tests.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Immunofluorescence labeling of NeuN, GFAP and Olig2 cell fate markers reveals reduced expression of GFAP (*p < 0.001) and Olig2 (*p < 0.05) in adult mouse NSCs treated with SAHA for 48 hours under proliferation culture conditions and then induced to differentiate for 14 days in culture (two-way ANOVA with Bonferroni post-tests). (b) Western blot of β-catenin protein in nuclear and cytoplasmic fractions of adult mouse NSCs treated with HDACi/vehicle control under proliferation culture conditions. Gapdh and lamin A/C blots are included as loading controls. (c) SAHA and NaB do not significantly alter nuclear/cytoplasmic levels of β-catenin in adult mouse NSCs. Histogram of β-catenin Western blot signal intensities normalized to loading controls (n = 4).

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Morphological changes and histone H3 phosphorylation of HB cells treated with a combination of VX-680 and SAHA. HUH6 and HepT1 were incubated with VX-680 (6 μM) and SAHA (0.5 μM). Nuclei diameter (a) and cell diameter (b) were determined 72 h later by DAPI staining and microscopy. Data represent mean±SD of the diameters from 20 cells in each experiment. (* Two-way ANOVA, Bonferroni test, p \0.05). c Western blot analysis on HUH6 and HepT1 cells were carried out with an anti-phospho-Histone H3 (Ser 10) antibody (p-H3) 24 h after incubation with VX-680 (10 μM), SAHA (0.2 μM) or a combination of both. Controls were left untreated. Western blot analysis showed a decrease in p–H3 after treatment with VX-680 ( lane 2 ) relative to controls ( lane 1 ) and an increase when SAHA was added ( lane 3 ). For the combination of VX-680 and SAHA (lane 4 ) no p-H3 was detected.

    Pediatr Surg Int 2012 28, 579-89. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Vorinostat promotes C2C12 differentiation.In the image, the red is the myotube indicating differentiation ,the blue is the nuclei.

     

     

    Dr. Akihiko Yoshimura of Akihiko Yoshimura. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Western blot analysis of Acetyl-H3 and H3. 0-20μM SAHA was added.

     

     

    Dr. Zhang of Tianjin Medical University. Vorinostat (SAHA, MK0683) purchased from Selleck.

产品安全说明书

HDAC抑制剂选择性比较

生物活性

产品描述 Vorinostat (suberoylanilide hydroxamic acid, SAHA)是一种HDAC抑制剂，无细胞试验中IC50为~10 nM。
特性 Vorinostat是广谱HDAC活性抑制剂，抑制I和II类酶 。
靶点
HDAC [1]
(Cell-free assay)
~10 nM
体外研究

Vorinostat是小分子量（<300）线性肟酸，抑制HDAC活性，包括乙酰化组蛋白和非组蛋白的积累，抑制培养细胞的增殖，且抑制肿瘤生长。Vorinostat通过结合到酶的活性位点而抑制 HDAC活性。Vorinostat 抑制多种转化细胞增殖（包括 淋巴瘤，多发性骨髓瘤，白血病，和非小细胞肺癌），与对照组相比抑制生长达50% 时的浓度为0.5 到10μM。Vorinostat作用于淋巴瘤和白血病细胞，包括 Burkitt, B-细胞急性淋巴细胞白血病 (B-ALL), MCL, DLBCL, ATL和T-细胞，不同程度抑制细胞增殖。除了抑制转化细胞增殖, Vorinostat 也抑制正常细胞增殖，通过比较Vorinostat 作用于一组细胞系–正常人非纤维细胞(WI-38)和 SV40巨大T抗原转化WI-38(VA-13细胞)而得到证明。Vorinostat 抑制两种类型细胞增殖，这种作用存在剂量依赖性。但发现Vorinostat 对转化细胞具有选择毒性，包括使肿瘤细胞死亡，而对正常细胞只起抑制作用，不会使其死亡。[1] Genistein 和Vorinostat 联用效果比5-aza和Vorinostat 联用作用于诱导细胞死亡有效很多。Genistein和Vorinostat联用作用于ARCaP-E使增殖降低 80 %，作用于ARCaP-M细胞，增殖降低60 %以上。Genistein和Vorinostat 联用抑制细胞增殖具有协同效应。作用于ARCaP-E 细胞(820个基因 诱导和1046个基因抑制) ARCaP-M 细胞，Vorinostat比Genistein 影响更多基因。[2] Vorinostat作用于肿瘤细胞表面，提高Fas蛋白水平，这种作用存在剂量依赖性，且按0.75 μM剂量处理，提高达到一个稳定水平。[3] Vorinostat 抑制肿瘤细胞生长，包括NB4, H460 和HCT-116，IC50分别为0.7μM, 3.4μM和1.2 μM。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 MnXxT4lv[XOnIFHzd4F6 NF7VVGUyKGh? NELMTYlFVVOR NIP1dFhidnSrLVjERWMyKGGldHn2bZR6KHerdHigTWM2OCCxZjCwMlEyOiEQvF2= MVmxNVk3ODR6OR?=
Friend leukemic cell NELPbohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;EUI0xPTBizszN NWjxdGxCPzJiaB?= NVnzboFCTE2VTx?= M4H0[mlEPTB;MD65PUDPxE1? NInXSoMyOjFyOUmxNy=>
K562 M4Hq[mtqdmG|ZTDBd5NigQ>? NG[3d3M3KGh? NW\VWJh2TE2VTx?= NIP5VFZKdmirYnn0bY9vKG:oIHj1cYFvKGirc4TvcoUh\GWjY3X0fYxie2ViKH3pfJR2emVib3[gTGRCSzFiYX7kJGhFSUN{KTD3bZRpKEmFNUCgc4YhOC5yMTFOwG0> NIPmdmQyOjRzOUO4NC=>
HT1080 NVXPU257T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVy3VYVkPzJiaB?= M{nXfWROW09? MYPJR|UxRTJwNDFOwG0> MoD2NVIzPzBzN{W=
H1299 NHjFeFJMcW6jc3WgRZN{[Xl? NGX0d|kzOCCvaX6= M4C3PGROW09? NIrQN|hKdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QhUESDQzDlcpp6dWVid3n0bEBKSzVyIH;mJFAvOTl2IN88US=> NFPB[ZIyPDV{MUSyNi=>
H1299 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{OyW|czKGh? NXPtdmE1TE2VTx?= Mkm3TWM2OD15LkK0JO69VQ>? MkXKNVQ2OjF2MkK=
HeLa MoTYT4lv[XOnIFHzd4F6 NV;QU4dUOzBibXnu MX7Jcohq[mm2b4L5JINwdmOnboTyZZRqd25iYXfhbY5{fCCqaYP0c45mKGSnYXPleJlt[XOnIIfpeIghUUN3MDDv[kAxNjJ6IN88US=> MmntNVU3ODN7NEm=
LOX-IMVI MkXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M321XVQ5KGh? MkDJTWM2OD1zLkOg{txO MnfiNVU4OTV2N{C=
NCI-H226 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXIOFghcA>? MV3JR|UxRTJwNjFOwG0> NFHaZoUyPTdzNUS3NC=>
RXF-631L MlHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfodWwyPDhiaB?= NEPW[mZKSzVyPUKg{txO MXmxOVcyPTR5MB?=
SNB-78 NGPjWFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU[0PEBp Ml7VTWM2OD1zNjFOwG0> M1rSd|E2PzF3NEew
St-4 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorBOFghcA>? M2DybGlEPTB;NT6yJO69VQ>? Mny5NVU4OTV2N{C=
ARP1 NWG1TlJ2TnWwY4Tpc44hSXO|YYm= MYGyJO69VQ>? MkTuOkBp M2HPOWlv\HWldHnvckBw\iCSMkHXRWYyKGenbnWg[ZhxemW|c3nvci=> MYKxOFc{PDhyNh?=
CEM NEH6W|VMcW6jc3WgRZN{[Xl? NX;FUppEOSCq NULPRlhITE2VTx?= MYrJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwM{Og{txO MorUNVY1OjByNkS=
HCT15 M3v5Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\pSHI1QCCq NX3lVFBbT0l3ME2wMlgzKM7:TR?= NYjFfWdOOTZ5MkOyNlc>
NCI-H23 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHflXVM1QCCq M13PdWdKPTB;MD65NkDPxE1? NGjUUm4yPjd{M{KyOy=>
GM15850 MWjLbY5ie2ViQYPzZZk> M1nyeVIvPSEQvF2= M2rKOFk3KGh? MVnEUXNQ M1fw[mlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFizJIx6e2mwZTCxOEBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= Mn7ENVY6OjF|Nke=
GM15850 NHHHRXBMcW6jc3WgRZN{[Xl? M1PLS|IvPSEQvF2= MoPCPVYhcA>? M3nQRmROW09? NFXoRW9KdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgOUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= NVfVWGUzOTZ7MkGzOlc>
GM15850 NH7nVIJMcW6jc3WgRZN{[Xl? NHrYeZczNjVizszN MmXKPVYhcA>? Ml:zSG1UVw>? Mkn0TY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEGyJIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n M2XaZ|E3QTJzM{[3
GM15850 M3i1U2tqdmG|ZTDBd5NigQ>? M376[FIvPSEQvF2= NWX0VW84QTZiaB?= M{WyOmROW09? MXvJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKMzDsfZNqdmViOTDhZ4V1gWyjdHnvckBw\iCIWF6g[4Vv\Q>? MWSxOlkzOTN4Nx?=
GM15850 MlHhT4lv[XOnIFHzd4F6 M33vTlIvPSEQvF2= MVq5OkBp NILQSZdFVVOR M3PxVWlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTC4JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n MVqxOlkzOTN4Nx?=
GM15850 MWnLbY5ie2ViQYPzZZk> MWeyMlUh|ryP MknRPVYhcA>? MV\EUXNQ MkP5TY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEG2JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n M3f5TVE3QTJzM{[3
U937 M1G5[WZ2dmO2aX;uJGF{e2G7 MmXHOUDPxE1? M{TCUFI1KGh? NVvBUGt7TE2VTx?= NFS3bGhE\WyuIHP5Z4xmKGG{cnXzeEBjgSCjY3P1cZVt[XSrb36gZZQhWy:JMj;NJJBp[XOn M3v4cVE4ODB2N{G4
H661 MlTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33h[|Q5KGh? M{WxTGlEPTB;MTFOwG0> NIr2OFMyPzF3N{CwPS=>
U937 MUTGeY5kfGmxbjDBd5NigQ>? MVu1JO69VQ>? Mk\5NlQhcA>? MXPEUXNQ NHLPNGVKdmO{ZXHz[UBqdiCqaYP0c45mKEh|IHHj[ZR6dGG2aX;u NUezOHJxOTd2NEe3OVA>
U937 M1HoZ2Z2dmO2aX;uJGF{e2G7 MWSxJO69VQ>? M1jH[|I1KGh? NIDSR5pFVVOR MkTuSYZn\WO2IH;uJIFteGijIIT1ZpVtcW5iYXPleJlt[XSrb36= M4D1OVE4PDR5N{Ww
RAW264.7 M3v3c2Z2dmO2aX;uJGF{e2G7 NH\NblEyOCEQvF2= NVzBdlFDOjSq NGrGTol4[XSnch?= NGfvdYlKdmirYnn0bY9vKG:oIFzQV{1{fGmvdXzheIVlKFSQRnHsdIhiKHC{b3T1Z5Rqd25id3n0bEBKSzVyIH;mJFAvPzZizszN NF[1N3cyPzR5N{WxPC=>
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Primary bronchial epithelial cell MmDVT4lv[XOnIFHzd4F6 NHnhTWg2KM7:TR?= M4rXSlI1KGh? NWjmRXZJTE2VTx?= MlfWTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwZIXjeIlwdiCxZjDteZRidnRiRnTlcJRiPTB6IFPGWHIheHKxdHXpckBieGmlYXygd5Vz\mGlZTDsc4NidGm8YYTpc44> MXWxPVk3Pjd6OR?=
Primary bronchial epithelial cell NYP2NVBXU2mwYYPlJGF{e2G7 MY[xJO69VQ>? NEXl[Zg6PiCq MnHESG1UVw>? MYfJcohq[mm2aX;uJI9nKEiGQVO3JIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIIPoc5J1KGOrcnP1bZQh[3W{cnXueJM> NF;ldWgyQTl4Nke4PS=>
BxPC3 NIPZTmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX63NkBp NX;2bGFYUUN3ME2yMlch|ryP MmTYNlAyPDN5N{i=
CAL27 M1n2PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{Tw[|czKGh? NHjJfo5KSzVyPUOuO|Ih|ryP NHrRTZUzODF2M{e3PC=>
Capan1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPmO|IhcA>? MWjJR|UxRTdwMzFOwG0> M3HqUFIxOTR|N{e4
HCC827 MkK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPTNmo4OiCq M2Dh[GlEPTB;MT64JO69VQ>? M1XycVIxOTR|N{e4
LNCAP NG\teYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3uO|IhcA>? M2[zO2lEPTB;MD61PEDPxE1? MXWyNFE1Ozd5OB?=
NCI-H2122 Mnm3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzzWXk4OiCq M3:4PGlEPTB;Nz61JO69VQ>? NHXUXokzODF2M{e3PC=>
NCI-H358 NGjaV3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvKe|FuPzJiaB?= M2[xPWlEPTB;Mj61JO69VQ>? MXmyNFE1Ozd5OB?=
SCC15 NVnMZlliT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXW3NkBp M{\FR2lEPTB;Mj60PUDPxE1? NV61fXFlOjBzNEO3O|g>
SCC25 NFu2SIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fD[lczKGh? Mn7STWM2OD1zLkmzJO69VQ>? NE\vRWIzODF2M{e3PC=>
SKHEP1 Ml62S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPPO|IhcA>? MoTjTWM2OD1|LkS2JO69VQ>? M3v2blIxOTR|N{e4
BJ NVTaXVAxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPINVAxKM7:TR?= NH\MOIs1QCCq MVjEUXNQ NWf3Om54T3Kxd4ToJIlvcGmkaYTpc44h[XRiMD6wOUB1dyBzMECgeW0> MUiyNFE1Ozh2MB?=
MUF NEjQd3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnwNVAxKM7:TR?= NIq0VVQ1QCCq NFvwXG9FVVOR MY\Hdo94fGhiaX7obYJqfGmxbjDheEAxNjB3IITvJFExOCC3TR?= NVnIN5BQOjBzNEO4OFA>
Caco-2 MlHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPRWo0yOTByIN88US=> M3jIblQ5cA>? NH\nRXlFVVOR MVLJR|UxRThwMTFOwG0> NXXTUFJUOjBzNEO4OFA>
Caco-2 NX7KPZVMU2mwYYPlJGF{e2G7 M4jEblUh|ryP MnywOEBp NEH0cmRFVVOR NET1clRKdmS3Y4Tpc44hd2ZiSFTBR{1u\WSrYYTl[EBpcXO2b37lJIFk\XS7bHH0bY9vKEmFNUCgc4YhOC5yM{eg{txO NIHPfGUzODF2M{i0NC=>
Caco-2 MonhT4lv[XOnIFHzd4F6 NEO0NlAxNjNzNjDuUUB1dyB|MT62JO69VQ>? NFv6cIo1KGh? NWPUdVdJTE2VTx?= NF;FTJFGgCC4aY\vJIlvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{Gge4l1cCCLQ{WwJI9nKDBwMUG5JO69VQ>? NXSyU5dTOjBzNEO4OFA>
Caco-2 NUTRbIZyU2mwYYPlJGF{e2G7 Mmf3NE4{OTZibl2geI8hOzFwNjFOwG0> MXq0JIg> Mm\kSG1UVw>? M4CzbGV5KH[rdn:gbY5pcWKrdHnvckBw\iCqdX3hckBJTEGFMzD3bZRpKEmFNUCgc4YhOC5zNEeg{txO M1vn[|IxOTR|OESw
Caco-2 Mn;lT4lv[XOnIFHzd4F6 NIryVI83NjN{IH7NJJRwKDZ|MjFOwG0> MknkOEBp MUPEUXNQ Mn;CSZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUN3IIfpeIghUUN3MDDv[kAyOi54IN88US=> NYnxN5JmOjBzNEO4OFA>
Caco-2 MU\LbY5ie2ViQYPzZZk> M1\S[|YvOzJibl2geI8hPjN{IN88US=> Mo\YOEBp NHfQVHBFVVOR NXTNbnlFTXhidnn2c{BqdmirYnn0bY9vKG:oIHj1cYFvKEiGQVO3JJdqfGhiSVO1NEBw\iB2MTFOwG0> MW[yNFE1Ozh2MB?=
Caco-2 NFfG[IFMcW6jc3WgRZN{[Xl? NELmZnAxNjNzNjDuUUB1dyB|MT62JO69VQ>? NFy3dIc1KGh? MX;EUXNQ MUnFfEB3cX[xIHnubIljcXSrb36gc4YhcHWvYX6gTGRCSzZ? M2rLOFIxOTR|OESw
HepG2 MoD4T4lv[XOnIFHzd4F6 MkDJOUDPxE1? NUPScnlTPmh? NYPZWnZDTE2VTx?= M{XFcWlv\HWldHnvckBw\iCKRFHDMY1m\GmjdHXkJIhqe3SxbnWgZYNmfHmuYYTpc44> MnLYNlAyPDN6NEC=
HepG2 M3LXVmtqdmG|ZTDBd5NigQ>? NFrpUGQ2KM7:TR?= MYS2bC=> NXi3PFdxTE2VTx?= M3;DfWlv\HWldHnvckBw\iCKRFHDMY1m\GmjdHXkJIhqe3SxbnWgbJlx\XKjY3X0fYxifGmxbh?= M4LFeFIxOTR|OESw
HepG2 NH\0cFJMcW6jc3WgRZN{[Xl? NVLHOVlQPSEQvF2= Ml;vOog> NWrDTJVVTE2VTx?= NFnKd2JKdmS3Y4Tpc44hd2ZiSFTBR{1u\WSrYYTl[EBidHCqYT30eYJ2dGmwIHHj[ZR6dGG2aX;u NFvndoYzODF2M{i0NC=>
HepG2 M2ruUmtqdmG|ZTDBd5NigQ>? MXO1JO69VQ>? MVO2bC=> M3PR[2ROW09? MUXJcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDIN{9JPCCqaYP0c45mKGGlZYT5cIF1cW:w NFPG[mszODF2M{i0NC=>
COLO205 NIrqdFJMcW6jc3WgRZN{[Xl? NW\GV3IyOTBizszN MkTrNlQhcA>? NHrJZ21FVVOR NYD2cm9bUW6qaXLpeIlwdiCxZjDISGFEOSCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4YhcGm|dH;u[UBJOyCjY3X0fYxifGmxbjD3bZRpKEmFNUCgc4YhOi5{IN88US=> NWnQeogyOjB2NUGzO|g>
SCC4 NXvzfmFmU2mwYYPlJGF{e2G7 M{P2V|Eh|ryP NEfROWszPGh? MWXJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5idIXieYxqdiCjY3X0fYxifGmxbh?= MmfMNlA1PTJ{MkW=
SCC4 MUPLbY5ie2ViQYPzZZk> NV7lTGttOSEQvF2= M3PiPFI1cA>? NVHscmFHUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgZYNmfHmuYYTpc44> NYLMNJptOjB2NUKyNlU>
SCC4 MXTGeY5kfGmxbjDBd5NigQ>? MXyxJO69VQ>? NWfid|V4PSCvaX6= NF:3VFZC\2:waYP0JIFkfGm4aYT5JIF1KF[GUjDhd5Nme3OnZDDhd{BqdmS3Y4Tpc44hd2ZiQ2nQNlQh\2WwZTDlfJBz\XO|aX;u MYGyNFQ2OjJ{NR?=
NB4 NILXTphHfW6ldHnvckBCe3OjeR?= MlPyOUDPxE1? NVfzR5JYOjRiaB?= MlPWSG1UVw>? NGT0NplE\WyuIHP5Z4xmKGG{cnXzeEBie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDhZ4N2dXWuYYTpc44h[XRicILlMWcyKHCqYYPl NWLoSllqOjB2OUG0OFA>
NB4 Mn3sT4lv[XOnIFHzd4F6 NInKR|g2KM7:TR?= MonvNlQhcA>? NFrKSpRFVVOR MWXJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iYXPleJlt[XSnIIT1ZpVtcW5ibHX2[Yw> M1z5N|IxPDlzNESw
NB4 M2LDW2Z2dmO2aX;uJGF{e2G7 NET5[Go2KM7:TR?= NGLmeXIzPCCq NGnJNVRFVVOR M2X0Omlv\HWldHnvckBw\iCyMkHXRWYyN0OLUEGg[ZhxemW|c3nvci=> NEL4e5ozODR7MUS0NC=>
NB4 NGPiOoZMcW6jc3WgRZN{[Xl? Mn7ZOUDPxE1? NXq5fGU{OjRiaB?= NXnFfmpqTE2VTx?= NHSxbmNKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIN{Bi[2W2eXzheIlwdg>? NHXmXXQzODR7MUS0NC=>
NUGC3 NIPyTGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHH3NYJIUTVyPUKuPVQh|ryP NIHrNpAzODh3MEm3NS=>
A549 NIq4dHJHfW6ldHnvckBCe3OjeR?= NGC3SXU2KM7:TR?= NV\0UJVKOyCq M1fz[GROW09? MonNTY5lfWO2aX;uJI9nKGG3dH;wbIFogSCrbjDoeY1idiCDNUS5JINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKEyFM1nJ MmfuNlA5PTV{MEi=
HUT78 M1LRdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LISFczKGh? MmK3SG1UVw>? NHvKeZhIUTVyPUCuN{DPxE1? NFPIR4MzODh6NEKwPC=>
U937 MnvIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\ad|czKGh? NYTpXVFrTE2VTx?= NWDBcZl2T0l3ME2wMlM6KM7:TR?= MkD0NlA5QDR{MEi=
A431 MYXDfZRwfG:6aXOgRZN{[Xl? MkPNO|IhcA>? MYfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOFMyKGOnbHzzJI93\XKneIDy[ZN{cW6pIFXHSnIhf2m2aDDJR|UxKG:oIESuNkDPxE1? MXeyNVA5ODZ{OR?=
A549 NGK2[WJEgXSxdH;4bYMhSXO|YYm= MoDBO|IhcA>? M{\Uc2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMhd3[ncnX4dJJme3OrbnegTGRCSyC5aYToJGlEPTBib3[gNU45KM7:TR?= NULXSoM6OjFyOEC2Nlk>
CAL27 MnHHR5l1d3SxeHnjJGF{e2G7 NYHoTXBTPzJiaB?= M3zVeWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNCVDJ5IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGVITlJid3n0bEBKSzVyIH;mJFMvOiEQvF2= MVeyNVA5ODZ{OR?=
HeLa M1HmNmN6fG:2b4jpZ{BCe3OjeR?= MmfpO|IhcA>? MkS0R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVN[SClZXzsd{BwfmW{ZYjwdoV{e2mwZzDISGFEKHerdHigTWM2OCCxZjCxMlUh|ryP NGHQ[JczOTB6ME[yPS=>
Sf21 MkLST4lv[XOnIFHzd4F6 MVKzJIg> NFrMOVlKdmirYnn0bY9vKG:oIF\sZYchfGGpZ3XkJIh2dWGwIILlZ49u[mmwYX70JGhFSUN6IHX4dJJme3OnZDD3bZRpKEmFNUCgc4YhOS5{IN88US=> Mlm5NlExQDB4Mkm=
SKBR3 MVHDfZRwfG:6aXOgRZN{[Xl? NH\wfWc4OiCq MXnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTT2JTOyClZXzsd{BwfmW{ZYjwdoV{e2mwZzDISXIzKHerdHigTWM2OCCxZjCyMlYh|ryP NYL3Um9EOjFyOEC2Nlk>
SKOV3 M2LNN2N6fG:2b4jpZ{BCe3OjeR?= NIr3b4Y4OiCq M2nzSWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMV1Z|IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhGWjJid3n0bEBKSzVyIH;mJFIvOiEQvF2= NH7wN3IzOTB6ME[yPS=>
COR-L23 Ml\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYexNEDPxE1? MlHLO|IhcA>? MmHRSG1UVw>? NX7ZfXBiT0l3ME2xMlEh|ryP M4joOFIyODhyNkS3
DU145 Mnr1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjROmJvOTBizszN M2jERVczKGh? MX;EUXNQ NFqwbWxIUTVyPUGuNFUh|ryP Mk\oNlExQDB4NEe=
LoVo MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{m1cFExKM7:TR?= Mo\kO|IhcA>? MYHEUXNQ M2r6V2dKPTB;MT63JO69VQ>? MV[yNVA5ODZ2Nx?=
MCR5-SV2 Ml3BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnzcVQyOCEQvF2= NUX2U29wPzJiaB?= MUHEUXNQ MnjRS2k2OD1{LkGg{txO MlPnNlExQDB4NEe=
HCT116 NXzuT5V{U2mwYYPlJGF{e2G7 NF20W48{OCEQvF2= NIfheWk{OCCq MXnEUXNQ Mlq0TY5pcWKrdHnvckBw\iCKRFHDOkBie3Onc4Pl[EBieyCrbnT1Z5Rqd25ib3[gZYxxcGFvdIXieYxqdiCjY3X0fYxifGmxbh?= NEDMPXgzOTB6ME[0Oy=>
HCT116 MomxT4lv[XOnIFHzd4F6 NFXUfWc{OCEQvF2= MWKzNEBp MXzEUXNQ NFTNfY9KdmirYnn0bY9vKG:oIFjERWMyKGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBpcXO2b37lJGg{UzliYXPleJlt[XSrb36= MU[yNVA5ODZ2Nx?=
U937 NELiOYpMcW6jc3WgRZN{[Xl? NYniW|hVPSEQvF2= MnyzNlQhcA>? NUXxfJViTE2VTx?= NFPtSpNKdmirYnn0bY9vKG:oIHjpd5RwdmViYXPleJltfHKjboPm[ZJie2ViYYPz[ZN{\WRiYYOgbY5kemWjc3Wgc4Yh[WOndInsZZRqd25ib3[gbIl{fG:wZTDIN{BifCCNOR?= MWiyNVI6OjR7Mh?=
U937 NWnhW3YxU2mwYYPlJGF{e2G7 M1PVXVUh|ryP MUGyOEBp NX;xcZFrTE2VTx?= MnLaTY5pcWKrdHnvckBw\iCqaYP0c45mKGGlZYT5cJRz[W6|ZnXyZZNmKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIH;mJIFk\XS7bHH0bY9vKG:oIHjpd5RwdmViSEOgZZQhUzF6 NGTVUpUzOTJ7MkS5Ni=>
U937 NHPrSo1McW6jc3WgRZN{[Xl? NHTpUoU2KM7:TR?= MVyyOEBp NXKwTlFVTE2VTx?= M{D1ZWlvcGmkaYTpc44hd2ZiaHnzeI9v\SCjY3X0fYx1emGwc3\ldoF{\SCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDv[kBx[W5vYXPleJlt[XSnZDDobZN1d26nIFi0JIxmfmWu MluxNlEzQTJ2OUK=
U937 M{fFOWtqdmG|ZTDBd5NigQ>? NYD0V2tUPSEQvF2= NF\URVAyPSCvaX6= MWDEUXNQ NHG2PJVKdmirYnn0bY9vKG:oIHjpd5RwdmViYXPleJltfHKjboPm[ZJie2ViYYPz[ZN{\WRiYYOgbY5kemWjc3Wgc4YhcGm|dH;u[UBJOyCjY3X0fYxifGmxbjDs[ZZmdA>? MYGyNVI6OjR7Mh?=
A2780 MlHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEm2fIs6PiCq M4DJe2ROW09? Mom5TWM2OD1zLk[yJO69VQ>? NU\rb2ZtOjF4M{S0N|A>
COLO205 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnQWY06PiCq NXTy[3ZYTE2VTx?= NF:zSXRKSzVyPUKuNVIh|ryP MmTaNlE3OzR2M{C=
Hep3B NXzsSmNvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjGNIVLPDhiaB?= MVzEUXNQ NUTaR5FlT0l3ME2xMlIyKM7:TR?= NITmZVMzOTdzMkG0Oi=>
GM11272 MVHGeY5kfGmxbjDBd5NigQ>? MofQNVAxKG6P M3HL[VczKGh? MVnEUXNQ MYPS[YFkfGm4YYTpc44hd2ZiTXXDdFIhdXW2YX70JIV5eHKnc4Ppc44h[XRiMUCgeI8hOTByIH7N NWi3eIREOjF6NEC3NVY>
CFBE41o M4r3XmtqdmG|ZTDBd5NigQ>? M1XBW|Uh|ryP MnTpSG1UVw>? NXXkb5pmTG:5bjDy[Yd2dGG2aX;uJI9nKEiGQVO3JIF1KDBwMjD0c{A2KHWP M{TvWVIyQTh2OUW4
CFBE41o MV\GeY5kfGmxbjDBd5NigQ>? NWPLXYJQOSEQvF2= NXTSU|Z3OjRiaB?= MUPEUXNQ NUS2V4w5WmW|dH;yZZRqd25ib3[gR2ZVWiCmZXz0ZWY2ODhibYX0ZY51KHS{YX\mbYNscW6pIITvJINmdGxic4Xy[oFk\SCjczDncJlkd2[xcn3z M4\BbVIyQTh2OUW4
DU145 M1jiW2tqdmG|ZTDBd5NigQ>? NHXOdpQzNjVizszN MVmyOEBp MmrPSG1UVw>? NF\iVGFKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNidYDy[Yd2dGG2aX;uJI9nKHB{MYfh[lEheHKxdHXpckBmgHC{ZYPzbY9v NXLI[ZRpOjJ{NkCxOlY>
DU145 NGr2[WNMcW6jc3WgRZN{[Xl? MljFOUDPxE1? MXiyOEBp M1vPSWROW09? NUnBXHNQUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHjpd5RwdmViSESgZYNmfHmuYYTpc44> MmPvNlIzPjBzNk[=
DU145 MVfLbY5ie2ViQYPzZZk> NULBPZZjPSEQvF2= MXOyOEBp NXL5XXBsTE2VTx?= NXLrdYhQUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHjpd5RwdmViSEOgbJlx\XKjY3X0fYxifGmxbh?= MmDhNlIzPjBzNk[=
786-0 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTmbY03NjJizszN Ml7LO|IhcA>? MojZSG1UVw>? M{G2T2dKPTB;Mz6yJO69VQ>? MUCyNlQ{PTZ4OR?=
A498 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYi2MlIh|ryP NWroUI9GPzJiaB?= MYXEUXNQ NXuw[ZNOT0l3ME2xMlYh|ryP M2fLcVIzPDN3Nk[5
A549/ATCC M2i0TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYP1Z3d5Pi5{IN88US=> NGnoRVU4OiCq NV;FXFVsTE2VTx?= MmDvS2k2OD1zLk[g{txO NIL5OY0zOjR|NU[2PS=>
ACHN MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYq2MlIh|ryP NHXGVHM4OiCq NFL5em1FVVOR MUnHTVUxRTFwMzFOwG0> NGnjRXkzOjR|NU[2PS=>
BT549 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrYT3FpPi5{IN88US=> MX:3NkBp NWHuSW9ITE2VTx?= MULHTVUxRTFwMzFOwG0> Mn3NNlI1OzV4Nkm=
EKVX NWfBdmc6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPNdotZPi5{IN88US=> NH;uPW84OiCq Mmq0SG1UVw>? M1jOdWdKPTB;MT6zJO69VQ>? NV\u[29wOjJ2M{W2Olk>
HCT15 NXv5d21iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfQOk4zKM7:TR?= M2n0flczKGh? MUjEUXNQ MX;HTVUxRTJwNTFOwG0> M1q5OVIzPDN3Nk[5
HOP92 Mn\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLWOk4zKM7:TR?= NXnyXol5PzJiaB?= NWPKeJBzTE2VTx?= MnzGS2k2OD12IN88US=> NWLmWnRzOjJ2M{W2Olk>
IGROV1 Mn7yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETMcpM3NjJizszN MV[3NkBp MVXEUXNQ NI\uXnRIUTVyPUGuN{DPxE1? MmfqNlI1OzV4Nkm=
LOXIMVI NIPEd5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHnRoI3NjJizszN Mn7UO|IhcA>? MkG2SG1UVw>? M1uw[mdKPTB;MTFOwG0> MXiyNlQ{PTZ4OR?=
M14 NWHqRmJ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrVOk4zKM7:TR?= MVy3NkBp MmPISG1UVw>? NUTNXXRPT0l3ME2xMlMh|ryP M1nxdVIzPDN3Nk[5
MALME-3M MmjmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY[2MlIh|ryP M4TQelczKGh? NXG0PGlCTE2VTx?= M2PoTmdKPTB;MD6zNkDPxE1? MVuyNlQ{PTZ4OR?=
MCF10A M{\rT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLkNlQ3NjJizszN MlvpOFghcA>? NUflT5hlTE2VTx?= NFfIXoRIUTVyPUmuOkDPxE1? NEPsRlYzOjR|NU[2PS=>
MDA-MB-435 NUe4bolYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYm2MlIh|ryP NXzVWpRNPzJiaB?= MUfEUXNQ NWHsUIExT0l3ME2wMlUh|ryP MVWyNlQ{PTZ4OR?=
MDA-MB-468 M4rhUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfScoN5Pi5{IN88US=> NVzSd3IzPzJiaB?= NGTwdIZFVVOR Mkj3S2k2OD1yLk[zJO69VQ>? NHHac4EzOjR|NU[2PS=>
MOLT4 MkTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrhSXQxPi5{IN88US=> NI\OPYw4OiCq NUTKWIxOTE2VTx?= M1X2ZWdKPTB;MD60JO69VQ>? NVL1RohxOjJ2M{W2Olk>
NCI-ADR-RES M1HBfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX:2MlIh|ryP MmnqO|IhcA>? MlW2SG1UVw>? MX\HTVUxRTBwMU[g{txO NFLJUVEzOjR|NU[2PS=>
NCI-H23 M3T5e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zUNVYvOiEQvF2= NH;k[XI4OiCq M1fT[2ROW09? NGTk[odIUTVyPUGg{txO MmTaNlI1OzV4Nkm=
NCI-H322M MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTNVGY3NjJizszN MX[3NkBp NWOzWJN2TE2VTx?= NIPaVZNIUTVyPUCuO|kh|ryP Mmm5NlI1OzV4Nkm=
NCI-H460 MlOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGToeGQ3NjJizszN NH7CWHM4OiCq MkS5SG1UVw>? MXfHTVUxRTBwN{mg{txO NWHnUGpwOjJ2M{W2Olk>
NCI-H522 MoK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mor0Ok4zKM7:TR?= M4\NbVczKGh? NHm4dYlFVVOR MlvaS2k2OD1yLkWg{txO MUSyNlQ{PTZ4OR?=
OVCAR3 NY\6fZZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{T6WFYvOiEQvF2= MYW3NkBp NHHIVmJFVVOR NW\FNmpKT0l3ME2xMlMh|ryP MY[yNlQ{PTZ4OR?=
OVCAR4 NIXBeZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XJNVYvOiEQvF2= MXO3NkBp NXfIZ4R4TE2VTx?= NH;aTHBIUTVyPUSg{txO Mn;mNlI1OzV4Nkm=
OVCAR5 NHHwTnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3SPHFyPi5{IN88US=> NIHWfno4OiCq NWHST5p6TE2VTx?= NYnyeo4xT0l3ME2wMlc6KM7:TR?= Ml;SNlI1OzV4Nkm=
OVCAR8 M1i5WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFKyVWg3NjJizszN MX[3NkBp NGraOodFVVOR M3nOVmdKPTB;MD61JO69VQ>? NYe2[mZsOjJ2M{W2Olk>
RXF393 M4TRSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3HOk4zKM7:TR?= Ml;ZO|IhcA>? MoHWSG1UVw>? NWjmWZNYT0l3ME2xMlMh|ryP MYOyNlQ{PTZ4OR?=
SF268 MnLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnnXJY3NjJizszN NWT0dnJQPzJiaB?= M3HMVGROW09? MVvHTVUxRTFwNjFOwG0> M2fvU|IzPDN3Nk[5
SF295 NGXYXnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmCzOk4zKM7:TR?= M{jid|czKGh? MnLhSG1UVw>? NHLyRXlIUTVyPUGuOkDPxE1? NEPDRZkzOjR|NU[2PS=>
SF539 NYfaV2hkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrTW|VPPi5{IN88US=> NXHvOHdHPzJiaB?= Moe3SG1UVw>? MYTHTVUxRTJizszN NWnnV2JFOjJ2M{W2Olk>
SK-MEL-2 NUPCeIIyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13xPVYvOiEQvF2= M2L2VVczKGh? M1mxcGROW09? NFXpNVZIUTVyPUGuN{DPxE1? NH\hcI8zOjR|NU[2PS=>
SK-MEL-28 M2LpOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPJOk4zKM7:TR?= NVPoZY9FPzJiaB?= M{\6c2ROW09? NHXX[5dIUTVyPUGg{txO NFnQVWMzOjR|NU[2PS=>
SK-MEL-5 M4fhPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXq2MlIh|ryP NFv5dos4OiCq MYLEUXNQ Mm\rS2k2OD1yLk[zJO69VQ>? NEfkZ5EzOjR|NU[2PS=>
SKOV3 M1;1emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPoZYJJPi5{IN88US=> M{PTTFczKGh? MoHoSG1UVw>? NUKzeI43T0l3ME2xJO69VQ>? NWDGXYczOjJ2M{W2Olk>
SN12C MkPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzjT|N{Pi5{IN88US=> NF\wb3g4OiCq MYTEUXNQ MVXHTVUxRTJizszN MnzkNlI1OzV4Nkm=
SNB19 M2DyWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX:2MlIh|ryP NYLhZ|FqPzJiaB?= MWjEUXNQ NUPmVGdHT0l3ME2wMlY{KM7:TR?= M{OzO|IzPDN3Nk[5
SNB75 NIrKZo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUG2MlIh|ryP MWG3NkBp MYDEUXNQ MXPHTVUxRTBwN{mg{txO MoPZNlI1OzV4Nkm=
SR MlfFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXW2MlIh|ryP MVq3NkBp NUPTboozTE2VTx?= Mn:3S2k2OD1yLkSg{txO MY[yNlQ{PTZ4OR?=
T47D NW\Zdmg4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnQXGE3NjJizszN MojqO|IhcA>? NH\S[ZJFVVOR Ml;mS2k2OD1yLkWg{txO NY\sfGRoOjJ2M{W2Olk>
TK10 MlnRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXaWYs3NjJizszN MVW3NkBp MljlSG1UVw>? M1Hme2dKPTB;MD62N{DPxE1? MVuyNlQ{PTZ4OR?=
UACC257 M1K4OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HmbFYvOiEQvF2= MWe3NkBp NH:3No1FVVOR MmjJS2k2OD1yLkWg{txO NVvkVItqOjJ2M{W2Olk>
UACC62 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXe2MlIh|ryP M1\jTFczKGh? M2DUS2ROW09? NIOxU4tIUTVyPUCuOEDPxE1? NH:1foszOjR|NU[2PS=>
UO31 M2S5dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\pXpZtPi5{IN88US=> MmjKO|IhcA>? NF:5[|NFVVOR MVrHTVUxRTBwNTFOwG0> NVHqWpc3OjJ2M{W2Olk>
Hep3B NIfOd41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXRdlQ1QCCq NI\kdXRFVVOR Mn;GS2k2OD1yLk[5JO69VQ>? M3TXdFIzPDN7OE[z
BE(2)-C NYjp[I4zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4O0U|czKGh? M2HYZmROW09? NIDqeJVKSzdyPUKg{txO M2HLW|IzQTN{M{G2
Bel7402 NXTsXFVVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjsbJVrPzJiaB?= MkOwSG1UVw>? NWDKNIR1T0l7ME2xO{DPxE1? NHe2VGQzOzB4MUO3Oi=>
Bel7404 Ml3uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjVeoVpPzJiaB?= MnPPSG1UVw>? MWrHTVkxRTF6IN88US=> MlW5NlMxPjF|N{[=
BGC823 NUj3PJJWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDvPHpxPzJiaB?= NIT0XJpFVVOR NF7xdo9IUTlyPUeuOUDPxE1? MknNNlMxPjF|N{[=
MGC803 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fnVFczKGh? MWjEUXNQ NG[yRWZIUTlyPUGwMlgh|ryP M3uwTFI{ODZzM{e2
SGC7901 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWS3UGhQPzJiaB?= Ml7hSG1UVw>? M2Gz[WdKQTB;OT60JO69VQ>? MonGNlMxPjF|N{[=
SKHEP1 MnuyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXnO|IhcA>? M3vtV2ROW09? NGrOc5ZIUTlyPUG3JO69VQ>? Mm\rNlMxPjF|N{[=
SMMC7721 MnHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUSyRpluPzJiaB?= Mm\PSG1UVw>? Ml7kS2k6OD1{MDFOwG0> NF7yOnAzOzB4MUO3Oi=>
NUGC3 M{jEPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XSUFExKM7:TR?= NWT6fmtWT0l;Mj65OEDPxE1? MlnnNlMyPjN|M{K=
A2780 CisR MWfLbY5ie2ViQYPzZZk> NHznOGMyQCCq MVTJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNESg{txO M1PiPVI{OjV{NkCz
CAL27 sens M2DUcGtqdmG|ZTDBd5NigQ>? M17wc|E5KGh? M1nKRmlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD6zOkDPxE1? NHjVNVUzOzJ3Mk[wNy=>
CAL27 CisR NHXyZZBMcW6jc3WgRZN{[Xl? NF7IbnkyQCCq MV3Jcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNkGg{txO M{XSbFI{OjV{NkCz
KYSE-510 CisR NX6wRm53U2mwYYPlJGF{e2G7 Mn3xNVghcA>? NVTPRm51UW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlU6KM7:TR?= MW[yN|I2OjZyMx?=
KYSE-510 sens MnvPT4lv[XOnIFHzd4F6 M{T5cFE5KGh? NFS3eZdKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuO{DPxE1? M{LoWVI{OjV{NkCz
MDA-MB-231 sens MWPLbY5ie2ViQYPzZZk> M{LqNlE5KGh? MUjJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNkGg{txO NEDXSXEzOzJ3Mk[wNy=>
MDA-MB-231 CisR NXKzenlIU2mwYYPlJGF{e2G7 M3fJPFE5KGh? M33DPGlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1? M2Hsd|I{OjV{NkCz
ES2 NHzVd5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzzVGtbPDhiaB?= NYTHellWTE2VTx?= NHHNVIZKSzVyPUGyMlch|ryP M1K5TlI{PDl|NES5
MDA-MB-231 M2HwN2tqdmG|ZTDBd5NigQ>? Mlj6NVAh|ryP MX[zNEBucW5? NY\mRoZoTE2VTx?= NEfoW5NKdmirYnn0bY9vKG:oIFjERWMz[Q>? M4PIfVI{PDl|NES5
MDA-MB-231 MX;LbY5ie2ViQYPzZZk> Mom1NUDPxE1? MlzTNlQhcA>? MUTEUXNQ MYXJcohq[mm2aX;uJI9nKEiGQVO2JIF{e2W|c3XkJIF{KGGlZYT5cIF1cW:wIHzleoVteyCxZjD0eYJ2dGmw M3;B[|I{PDl|NES5
HS68 NGfrd4FEgXSxdH;4bYMhSXO|YYm= MnzKNVAh|ryP NYj3N5dTPzJiaB?= MY\EUXNQ Mlu0TWM2OD12Lk[g{txO NYHw[4VLOjN3N{C1OFI>
MEF MYDDfZRwfG:6aXOgRZN{[Xl? NVrN[JhwOTBizszN NHfkWFA4OiCq NILyTVhFVVOR MUDJR|UxRTRwNDFOwG0> M4D2OlI{PTdyNUSy
BGC823 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfP[|BZTE2VTx?= NHP1TmpIUTVyPUOuNFkh|ryP M2\GWVI{PjBzN{C2
High5 MX;LbY5ie2ViQYPzZZk> NXHZOlhKOjRiaB?= MWfJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEiGQVO2JJdqfGhiSVO1NEBw\iByLkC5JO69VQ>? MWWyN|YxOjV{Mx?=
High5 MlXMT4lv[XOnIFHzd4F6 MWCyOEBp MmOyTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCKRFHDNUB4cXSqIFnDOVAhd2ZiMD6xNkDPxE1? M{m5VVI{PjB{NUKz
High5 NXrnNI9lU2mwYYPlJGF{e2G7 M3\LdlI1KGh? MYTJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEiGQVOzJJdqfGhiSVO1NEBw\iByLkG3JO69VQ>? NV62e282OjN4MEK1NlM>
A549 MonQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LXPGROW09? MlXZTWM2OD1zLkC3PUDPxE1? M{HpcFI{PjR2MkGw
HCT116 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnXSG1UVw>? MnvuTWM2OD1yLke1O{DPxE1? NXzZVoY6OjN4NESyNVA>
K562 NWfJb|FGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jnWWROW09? MYDJR|UxRTBwNkS1JO69VQ>? NIHYOYgzOzZ2NEKxNC=>
GBC-SD MmnKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYC1JO69VQ>? M1X4[VczKGh? MoLOSG1UVw>? NIPHWFNKSzVyPUG0Mlgh|ryP NEPofYQzOzdyN{K2NC=>
HGC27 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TBR|Uh|ryP MmrKO|IhcA>? M1\CbGROW09? M4PqXGlEPTB;NT60JO69VQ>? NWfNc3p5OjN5MEeyOlA>
HL60 Mn3LT4lv[XOnIFHzd4F6 MojxOUDPxE1? MlL0NlQhcA>? MmDUSG1UVw>? M2DhV2lvcGmkaYTpc44hd2ZiSFTBRy=> NHj6NZIzOzdyN{K2NC=>
Vero M2jHWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLoSog4OiCq NYHWToY{TE2VTx?= NX\UR|AyUUN3ME2wMlkh|ryP M2PZPFI{Pzh4NEWy
NCI60 M4XVVmN6fG:2b4jpZ{BCe3OjeR?= M{G3W|Q5KGh? M4nx[2ROW09? Mlm0S2k:OC53MzFOwG0> MnrhNlQxOTV|Mke=
SW620 NUPCVIhQS3m2b4TvfIlkKEG|c3H5 MWi0PEBp MUjEUXNQ NV3HWVlRT0l;MD61OEDPxE1? NEfKeoIzPDBzNUOyOy=>
U251 MkfVR5l1d3SxeHnjJGF{e2G7 M3jXT|Q5KGh? MkHYSG1UVw>? MonzS2k:OS53MzFOwG0> NVX3U4o4OjRyMUWzNlc>
KM12 MWjDfZRwfG:6aXOgRZN{[Xl? NH3kPJU1QCCq M4XK[2ROW09? NHGyWpdIUT1zLki4JO69VQ>? MmS5NlQxOTV|Mke=
Hs578T MULDfZRwfG:6aXOgRZN{[Xl? NWrSTJh4PDhiaB?= MX;EUXNQ MkHhS2k:PC56MzFOwG0> MXWyOFAyPTN{Nx?=
MDA-MB-231 M1G2S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXyfFc1QCCq NEnx[XRKSzVyPUCuNVYh|ryP M1HiZ|I1ODl3MEG2
MCF7 NFL2VXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnm4OFghcA>? MVfHTV0xNjR3IN88US=> M3f6NlI1OTF7NUW1
MDA-MB-435 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XWclQ5KGh? MknzS2k:OC56ODFOwG0> NVvuPGdUOjRzMUm1OVU>
AsPC1 NXjKfJdrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HuNVMxKM7:TR?= MUW0PEBp MV\EUXNQ MYLJR|UxRTNwNk[g{txO MX6yOFE5PTN5OB?=
Jurkat E6.1 NGPxd5hMcW6jc3WgRZN{[Xl? MWiyJIg> M4rBe2ROW09? NYe4dnRuUW6qaXLpeIlwdiCxZjDISGFEPCC5aYToJGlEPTBib3[gNE4xPCEQvF2= MWWyOFI3OTh4Mh?=
KG1 M1X2[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVqwdppYPDhiaB?= MVTJR|UxRTFwMUWg{txO NETxWYMzPDV{NUCwNy=>
HEL M2TiXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zKdFQ5KGh? NHfuWIJFVVOR NV6xPHNwUUN3ME2wMlQ6KM7:TR?= MkPsNlQ3QTRyNUW=
HSC3 NUPiXHZGS3m2b4TvfIlkKEG|c3H5 NGPY[nYyOiCq NXTQWVA4TE2VTx?= M3q2PGlEPTB;MD63NUDPxE1? MYOyOFc3PjV4MB?=
HT-29 MmK3R5l1d3SxeHnjJGF{e2G7 MYGxNkBp MlnoSG1UVw>? NYHRcFd3UUN3ME2wMlczKM7:TR?= NHz3fVkzPDd4NkW2NC=>
KB NH;IRWJEgXSxdH;4bYMhSXO|YYm= Mo\wNVIhcA>? NIfxS49FVVOR M1XNSmlEPTB;MD63OUDPxE1? NF;lT5AzPDd4NkW2NC=>
H460 M3LhbWN6fG:2b4jpZ{BCe3OjeR?= M{XEZ|EzKGh? M{jIbWROW09? MU\JR|UxRTBwOEKg{txO MnvBNlQ4PjZ3NkC=
MONE1 MXrDfZRwfG:6aXOgRZN{[Xl? MVexNkBp Mn36SG1UVw>? NGTvcmlKSzVyPUGuNVgh|ryP MoDmNlQ4PjZ3NkC=
MKN45 NYLpVlE1S3m2b4TvfIlkKEG|c3H5 NVnNR4lbOTJiaB?= MmjJSG1UVw>? NVXjTmdlUUN3ME2xMlI2KM7:TR?= NGjXNFkzPDd4NkW2NC=>
TSGH MVjDfZRwfG:6aXOgRZN{[Xl? M1uzcVEzKGh? NYHHeWhMTE2VTx?= NXjWTJRYUUN3ME2yMlA6KM7:TR?= MWCyOFc3PjV4MB?=
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EFM-19 M4TPRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLFTWM2OD1zLkC0PFc6KM7:TR?= MYjTRW5ITVJ?
Ca9-22 MoTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTjTWM2OD1zLkC1NVA4KM7:TR?= NFLy[phUSU6JRWK=
NBsusSR NGLmPVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXJUmZoUUN3ME2xMlA2OTZ4IN88US=> NVP3TIlzW0GQR1XS
NB13 MljKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDiWFRKSzVyPUGuNFU2ODFizszN Mo\DV2FPT0WU
SF295 Mmi0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXOTWM2OD1zLkC2OlI1KM7:TR?= MXfTRW5ITVJ?
U-2-OS NH75[YtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLLTWM2OD1zLkC3PVEyKM7:TR?= M2LuR3NCVkeHUh?=
NCI-H526 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjCc3JZUUN3ME2xMlA5OjlzIN88US=> NXHQPZNzW0GQR1XS
KMOE-2 MnnQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\ITWM2OD1zLkC5OFIzKM7:TR?= Mmr5V2FPT0WU
RCM-1 MlT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HV[mlEPTB;MT6xNlExOiEQvF2= M3LrenNCVkeHUh?=
MC116 M4nleWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzaTWM2OD1zLkGzOlIyKM7:TR?= Mn3pV2FPT0WU
NCI-H1092 NVGzR2c4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTFwMUW0NFYh|ryP M2rVTnNCVkeHUh?=
EW-3 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;4TWM2OD1zLkG3NlEzKM7:TR?= NWnnZ2g1W0GQR1XS
HCT-116 M2fWT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTFwMUe3OUDPxE1? MWLTRW5ITVJ?
MC-IXC NUS2TIM{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLmfmNUUUN3ME2xMlE4QDhzIN88US=> MkfFV2FPT0WU
LB1047-RCC MlPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXWTWM2OD1zLkG4N|EzKM7:TR?= M3TB[XNCVkeHUh?=
VM-CUB-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;VV2lEPTB;MT6xPVExQCEQvF2= MUjTRW5ITVJ?
NB5 NXjwRZpFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTFwMUm4OVYh|ryP MWXTRW5ITVJ?
SKG-IIIa MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLrfmlLUUN3ME2xMlI{PDZ2IN88US=> NYH6N25OW0GQR1XS
HO-1-N-1 NYLxe4NzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rwe2lEPTB;MT6yN|g{PSEQvF2= NYXBNpNUW0GQR1XS
EFO-27 NXzPe4ZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVO4PWhbUUN3ME2xMlI2ODR|IN88US=> M13wWnNCVkeHUh?=
MHH-NB-11 MmjaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjpeld3UUN3ME2xMlI5OzJ7IN88US=> NGrjUGFUSU6JRWK=
SW620 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorhTWM2OD1zLkK5NFE5KM7:TR?= NGPpV4RUSU6JRWK=
MOLT-16 M3HEWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTFwMkm3PVch|ryP NYDvOlI6W0GQR1XS
NTERA-S-cl-D1 NEDURYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHXXFNKSzVyPUGuN|E4PjFizszN MkXNV2FPT0WU
VA-ES-BJ M3nzWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTFwM{K0O|ch|ryP M1vUV3NCVkeHUh?=
HCC1419 NWCwc4hzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTFwM{SwNlch|ryP MX;TRW5ITVJ?
NCI-H69 NITrcY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTFwM{SxNVIh|ryP NFvnbHdUSU6JRWK=
DEL NUnUS3VNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnwZm1{UUN3ME2xMlM2OTZ{IN88US=> NYXUdY44W0GQR1XS
LXF-289 NVfifoZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDCfopHUUN3ME2xMlM2OjRizszN MojUV2FPT0WU
EW-11 MljvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTFwM{[wNlYh|ryP MkTCV2FPT0WU
KP-4 NV[1XWNLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn[wTWM2OD1zLkO3NFg2KM7:TR?= NIK3ZmRUSU6JRWK=
NOS-1 NYO1[oZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvoTWM2OD1zLkSxNVk1KM7:TR?= NEj2d2lUSU6JRWK=
SK-NEP-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTFwNEG2PVMh|ryP M1zOXnNCVkeHUh?=
LAMA-84 NHLuXohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PldWlEPTB;MT60N|k1PSEQvF2= Mm\mV2FPT0WU
ES5 Moi4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTFwNESzJO69VQ>? M3XrenNCVkeHUh?=
HuO9 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3zVpFzUUN3ME2xMlQ2OzZ{IN88US=> M1n4cXNCVkeHUh?=
COLO-684 NEXCUY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfKcGUzUUN3ME2xMlQ3OTF6IN88US=> NUnMdIRJW0GQR1XS
EW-24 NWiwSIRHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7WN45yUUN3ME2xMlQ3PTNzIN88US=> MknrV2FPT0WU
BV-173 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFi1TlRKSzVyPUGuOFczQTFizszN M3rq[nNCVkeHUh?=
NCI-H1770 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTPWVZoUUN3ME2xMlQ5PTN4IN88US=> MYXTRW5ITVJ?
HuP-T4 M3;4[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHziRWZKSzVyPUGuOFk{KM7:TR?= M{O2UXNCVkeHUh?=
TYK-nu NYj3coJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVf1WYREUUN3ME2xMlQ6QDVzIN88US=> NG\GOmVUSU6JRWK=
YH-13 MmDiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrBS5NKSzVyPUGuOFk5QTRizszN M1\oSXNCVkeHUh?=
H4 NGnrXINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTFwNUC5NVIh|ryP M4n1cHNCVkeHUh?=
OVCAR-8 NF3xSHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDQTWM2OD1zLkW0OFc4KM7:TR?= MYPTRW5ITVJ?
NCI-H23 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTFwNUS2OFUh|ryP M1jDPHNCVkeHUh?=
ES7 M3rFVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1H4fGlEPTB;MT61OFc4OyEQvF2= NH;xOYpUSU6JRWK=
COR-L88 NYW2coR{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTFwNU[0NlQh|ryP MWHTRW5ITVJ?
TI-73 MoLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTFwNUmwOkDPxE1? MVfTRW5ITVJ?
RT-112 NHPzXopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGD1dopKSzVyPUGuOVkzQDRizszN MVvTRW5ITVJ?
HuO-3N1 Mk[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXOwS2JrUUN3ME2xMlU6Ozh3IN88US=> NWnqUFRQW0GQR1XS
HC-1 NYG2c3h5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vremlEPTB;MT61PVg3PiEQvF2= MW\TRW5ITVJ?
HT55 NF;xb|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7kcY9uUUN3ME2xMlY2OTNzIN88US=> M1fnNnNCVkeHUh?=
IA-LM M2j3Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnsTWM2OD1zLk[5Nlc5KM7:TR?= MYjTRW5ITVJ?
EM-2 MnSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moj2TWM2OD1zLkewNFE1KM7:TR?= NILrNWtUSU6JRWK=
MHH-ES-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTFwN{C0N|Uh|ryP M3PFXXNCVkeHUh?=
CAL-27 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTFwN{C2NlEh|ryP NYPMbFNYW0GQR1XS
COLO-800 NFrXOoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTFwN{GxO|kh|ryP MYPTRW5ITVJ?
HCE-T NX7yRnBLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1H0SWlEPTB;MT63NVUh|ryP NI\nblVUSU6JRWK=
CAMA-1 M2S2[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nJV2lEPTB;MT63NVk4OSEQvF2= MmHBV2FPT0WU
LOXIMVI MnLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjLeopPUUN3ME2xMlczOTFizszN MWPTRW5ITVJ?
NH-12 Mn7iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2Ow[WlEPTB;MT63NlY6OSEQvF2= Ml\EV2FPT0WU
TCCSUP MmHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;mfmx1UUN3ME2xMlczQDJ7IN88US=> NX\lXXNyW0GQR1XS
MDA-MB-361 M1;abGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIn1eWVKSzVyPUGuO|MyPTdizszN MmfwV2FPT0WU
EW-16 M{HsN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fxOWlEPTB;MT63OFExPyEQvF2= MnXPV2FPT0WU
SNU-423 NYXO[nc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofJTWM2OD1zLke1PFI4KM7:TR?= NIPmZm5USU6JRWK=
Daoy M2\vS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2[2cmlEPTB;MT63OlMyQSEQvF2= M2\3N3NCVkeHUh?=
ES4 NFrleG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrNTWM2OD1zLke4O|QyKM7:TR?= NX;YOI5xW0GQR1XS
PFSK-1 M3rTW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HwPGlEPTB;MT64NFM4KM7:TR?= MnPmV2FPT0WU
ES3 M2DUOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUCyZmxmUUN3ME2xMlgzPjhzIN88US=> NGfOdGVUSU6JRWK=
ONS-76 NVT4O3lqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;aTWM2OD1zLkiyPFk4KM7:TR?= NIriRW5USU6JRWK=
JVM-3 NUnFWlVqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXroeJNjUUN3ME2xMlg2PDVzIN88US=> Mm\LV2FPT0WU
OS-RC-2 NVfB[mpUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDnTWM2OD1zLki3NVUyKM7:TR?= NFrId2VUSU6JRWK=
COLO-320-HSR MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTFwOEixPVch|ryP NX30cVU2W0GQR1XS
HN NX\kNWU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nrNmlEPTB;MT64PFczPSEQvF2= NGe0NmJUSU6JRWK=
HT MoX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTFwOEi5OFch|ryP M1H1[HNCVkeHUh?=
LoVo MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTFwOEm4NUDPxE1? NYPHSmpoW0GQR1XS
CGTH-W-1 NH3aNo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fn[2lEPTB;MT64PVk1PiEQvF2= NXX4OlJOW0GQR1XS
NB6 NYPKW457T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXi1O4hbUUN3ME2xMlkyOjl6IN88US=> NWHLcnQ4W0GQR1XS
EW-22 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWO0V4F1UUN3ME2xMlkzQDh5IN88US=> MljjV2FPT0WU
ES6 M1HJSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTFwOUO2N|Eh|ryP NYLjNmFoW0GQR1XS
SCC-15 M1nYT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLrTWM2OD1zLkmzPFE6KM7:TR?= NH72d2lUSU6JRWK=
HL-60 NVe0cXduT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTFwOUO5NFIh|ryP MX3TRW5ITVJ?
human HOP-92 NX:wS2hsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTsTWM2OD1zLkm0NFY2KM7:TR?= M2HJN3NCVkeHUh?=
SW626 M{jmbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWna[Wo6UUN3ME2xMlk1QDl7IN88US=> Ml:xV2FPT0WU
HEC-1 Ml7kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojUTWM2OD1zLkm1N|Yh|ryP NXrWc|F4W0GQR1XS
LB2241-RCC Mn64S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTFwOUiyN|Eh|ryP NYnFcIFZW0GQR1XS
Ramos-2G6-4C10 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nzZ2lEPTB;MT65PVQ6OyEQvF2= MV7TRW5ITVJ?
A101D MlP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTJwMkCzNFMh|ryP MWrTRW5ITVJ?
NCI-H446 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzR[pc1UUN3ME2yMlA1PTl7IN88US=> MY\TRW5ITVJ?
SBC-5 Ml3FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTaO5hrUUN3ME2yMlA3OTR5IN88US=> NIniWWpUSU6JRWK=
HOS NVTxUZB[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fT[WlEPTB;Mj6wO|Y2OyEQvF2= M2jK[nNCVkeHUh?=
K5 NF;NRotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3jV5ZXUUN3ME2yMlA4QDFzIN88US=> NGLZSFBUSU6JRWK=
HLE Mm\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUi5RmtiUUN3ME2yMlA5PTJ7IN88US=> MYDTRW5ITVJ?
HSC-2 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjIfohiUUN3ME2yMlEzQDl6IN88US=> MlPaV2FPT0WU
LCLC-97TM1 M4mzOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;ldJlPUUN3ME2yMlE1PTh|IN88US=> NFjqdYpUSU6JRWK=
DMS-273 NX:5RY5VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfvS4pKSzVyPUKuNVQ5OzdizszN NYj4U2htW0GQR1XS
TE-8 NETNUmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LPTGlEPTB;Mj6xOVc3PSEQvF2= MoO2V2FPT0WU
DSH1 MlTKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLsU|ZKSzVyPUKuNVY{QThizszN MV3TRW5ITVJ?
CAL-51 M{fnZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nPeGlEPTB;Mj6xOlY6QSEQvF2= M{TMW3NCVkeHUh?=
IST-SL1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELkV4RKSzVyPUKuNVY5PDRizszN M2[5ZnNCVkeHUh?=
GCT NVjTbnZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nJSGlEPTB;Mj6xO|c4KM7:TR?= M1PHXXNCVkeHUh?=
SW948 NVfSS3JtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlL5TWM2OD1{LkG4OFU3KM7:TR?= MWLTRW5ITVJ?
NOMO-1 NHTWdppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHHfHdlUUN3ME2yMlE6OzF5IN88US=> MV3TRW5ITVJ?
C8166 MnH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjOenBKSzVyPUKuNlE{OzRizszN NFWyNlRUSU6JRWK=
OC-314 NVjRTotOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3wepFKSzVyPUKuNlMzPTlizszN M{nKPXNCVkeHUh?=
CAL-39 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LF[mlEPTB;Mj6yN|YzPiEQvF2= MoHZV2FPT0WU
MDA-MB-453 NILEW4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHvTWM2OD1{LkK0Nlc2KM7:TR?= Moj6V2FPT0WU
A673 MmP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPMVYFKSzVyPUKuNlU5PjJizszN NWXqW|E2W0GQR1XS
HTC-C3 M4DOS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoC5TWM2OD1{LkK2PFUh|ryP M4nEcXNCVkeHUh?=
NCI-H1666 NEHtdohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3nbZhKSzVyPUKuNlgyOTFizszN NXXiVIlzW0GQR1XS
PSN1 MkfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jQd2lEPTB;Mj6yPFkyOyEQvF2= MlzPV2FPT0WU
GI-1 Mnz2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo[wTWM2OD1{LkOwOVQ{KM7:TR?= M4TMO3NCVkeHUh?=
HuH-7 MlTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DoWGlEPTB;Mj6zNFY{PyEQvF2= MYnTRW5ITVJ?
JAR MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLWNHBYUUN3ME2yMlMyQTh5IN88US=> M1m4dXNCVkeHUh?=
5637 NWPFe4lkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrNN2FKSzVyPUKuN|IyOjlizszN MWPTRW5ITVJ?
GB-1 M1LTN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn63TWM2OD1{LkOyN|M2KM7:TR?= NIDFOo9USU6JRWK=
KP-N-YS NHm4UIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3P6e2lEPTB;Mj6zNlYyPSEQvF2= MVTTRW5ITVJ?
OAW-42 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{W2TmlEPTB;Mj6zN|QyPiEQvF2= MnTFV2FPT0WU
8-MG-BA MoG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTJwM{O5NFYh|ryP NX\wPVNUW0GQR1XS
RH-18 NFzidJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETDRoFKSzVyPUKuN|UxOjJizszN MknGV2FPT0WU
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ACHN Mn;XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDjTWM2OD17LkK0PVc2KM7:TR?= MorGV2FPT0WU
D-392MG NWS4WIM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\xcWNKSzVyPUmuNlU4OTVizszN NYjnTlNiW0GQR1XS
no-11 Ml70S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTlwMk[wNlgh|ryP NVPkWoFUW0GQR1XS
KLE NFjaZZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrkTWM2OD17LkOyNlMzKM7:TR?= NHf5fo5USU6JRWK=
Calu-6 NEjiSVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLZTIt7UUN3ME25MlM4PTJ6IN88US=> M13yTnNCVkeHUh?=
LB831-BLC M4fTfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLHTW57UUN3ME25MlQ2OTdzIN88US=> NVfFdYQ4W0GQR1XS
SW684 M2T5b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWe3SmE2UUN3ME25MlQ3OTF4IN88US=> MVrTRW5ITVJ?
SH-4 M2DDfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknPTWM2OD17LkS5N|Y1KM7:TR?= MX7TRW5ITVJ?
IST-MES1 NVL6fYV{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\lVIJKSzVyPUmuOVE3PDRizszN MYjTRW5ITVJ?
Saos-2 M2Lpfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3[4[2lEPTB;OT61NlE6PSEQvF2= M1jsbnNCVkeHUh?=
NCI-H2087 NE\meY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\XZW1jUUN3ME25MlY4OzV{IN88US=> MUfTRW5ITVJ?
SCC-9 NGTCclhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTlwN{G4NVYh|ryP Moq0V2FPT0WU
MFE-280 NELkVJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7ke25TUUN3ME25MlczPzh3IN88US=> NWTpcXhRW0GQR1XS
BEN M3raSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPTdIJKSzVyPUmuPFIyPTlizszN MlK4V2FPT0WU
CP50-MEL-B MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHaTWM2OD17LkmyOFMzKM7:TR?= M13uV3NCVkeHUh?=
SK-MEL-28 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7MN3BKSzVyPUGwMlAyQTNizszN NEnIeINUSU6JRWK=
NCI-H2452 MnrGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk[zTWM2OD1zMD6xOkDPxE1? M3zkTnNCVkeHUh?=
NCI-H1395 M1;GN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTzT|ZTUUN3ME2xNE4yPzhizszN MULTRW5ITVJ?
NCI-H2052 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELRcWFKSzVyPUGwMlE5QDJizszN NGPHbYVUSU6JRWK=
A375 NXnZRYJTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2WwemlEPTB;MUCuNlQ2OiEQvF2= M2LjfnNCVkeHUh?=
HCC38 NF72d4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHyxUoFKSzVyPUGwMlMzOiEQvF2= NIPlbGxUSU6JRWK=
LK-2 MnLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHDTWM2OD1zMD60NlA5KM7:TR?= Ml;CV2FPT0WU
SF126 MnLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTFyLkS3Nlch|ryP NIjPUmpUSU6JRWK=
SK-MEL-1 NELVNXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXjTWM2OD1zMD63PFM5KM7:TR?= MlHuV2FPT0WU
ACN NWDsR3VGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHDS4xLUUN3ME2xNE45Pjd7IN88US=> Mk\VV2FPT0WU
BB30-HNC M{Dlb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvqfI1KSzVyPUGwMlg4OTFizszN NGHrTIpUSU6JRWK=
NCI-H747 NWjCXlVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rQSmlEPTB;MUCuPFc1PiEQvF2= NIDsZldUSU6JRWK=
KYSE-150 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XUcGlEPTB;MUGuNFM5PyEQvF2= NFnXe4dUSU6JRWK=
D-247MG NEnwSodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;mTWM2OD1zMT6xNFA6KM7:TR?= MnLXV2FPT0WU
BxPC-3 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTFzLkO3OFch|ryP NIfhd5FUSU6JRWK=
SK-MEL-30 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkn2TWM2OD1zMT60NFc6KM7:TR?= M3fuZ3NCVkeHUh?=
CAS-1 Mon4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2H6[mlEPTB;MUGuOFExQSEQvF2= MYHTRW5ITVJ?
no-10 NYG5SmtqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGW3d2RKSzVyPUGyMlEzOTdizszN NWSyXZlqW0GQR1XS
NCI-H2405 NXq3Rop[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nkR2lEPTB;MUKuNlA{PiEQvF2= M{WwXXNCVkeHUh?=
KGN M17Q[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPL[VJJUUN3ME2xNk4zQTBzIN88US=> NUHwO5p6W0GQR1XS
BB49-HNC NGDTXGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTF{LkO5OVYh|ryP MYXTRW5ITVJ?
NCI-H1693 NFvqV29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTF{LkW4NVYh|ryP MXzTRW5ITVJ?
RO82-W-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHBNXVKSzVyPUGzMlA3PDlizszN MWrTRW5ITVJ?
CAL-85-1 NVK3[ZZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn[yTWM2OD1zMz60N|k6KM7:TR?= MnT5V2FPT0WU
H-EMC-SS NV21VmZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;QTWM2OD1zMz65NVA1KM7:TR?= M2HxUXNCVkeHUh?=
SW1783 MkPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mof0TWM2OD1zND6yN|kyKM7:TR?= NX:4SWxRW0GQR1XS
LB771-HNC NI\6NmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnr0TWM2OD1zND60NVkh|ryP NG\WcmRUSU6JRWK=
HCC70 NFjuToZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTF2LkSyN|Mh|ryP NIrZe49USU6JRWK=
KNS-81-FD NIO1WnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlqzTWM2OD1zND63NFQ2KM7:TR?= MXLTRW5ITVJ?
KYSE-520 NV3lcJJxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnnWpBKSzVyPUG0MlkzPyEQvF2= NF32PYVUSU6JRWK=
TGBC24TKB MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvJTWM2OD1zND65OVM6KM7:TR?= M4XmVHNCVkeHUh?=
SNB75 NFnSNI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGntcHlKSzVyPUG1MlA4OjlizszN NXnkOJlEW0GQR1XS
SW872 M4XBPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\S[I9KSzVyPUG1MlIzOThizszN NUTCdJZ5W0GQR1XS
U031 NGCxNmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TjN2lEPTB;MUWuPFAzQCEQvF2= MnTIV2FPT0WU
ChaGo-K-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTF3LkizOVkh|ryP NHfX[W1USU6JRWK=
NCI-H441 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULzbnVLUUN3ME2xOk4xODN7IN88US=> NUn1Smt6W0GQR1XS
TE-12 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTF4LkG4O|Mh|ryP NWi4SJBIW0GQR1XS
NCI-H1755 Mmq0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjjW3NKSzVyPUG2MlU4OyEQvF2= M37TenNCVkeHUh?=
KNS-42 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;BZ2lEPTB;MU[uOlU5QSEQvF2= MnnRV2FPT0WU
SK-PN-DW M1TsU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfXN5NKSzVyPUG3MlQzODFizszN MXLTRW5ITVJ?
NCI-H226 MorpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYK5Wo57UUN3ME2xO{46OzR3IN88US=> NWTRTVJoW0GQR1XS
K-562 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHjfXd7UUN3ME2xPE43OzF5IN88US=> M1n0N3NCVkeHUh?=
A388 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPTVGdmUUN3ME2xPU4xOzB|IN88US=> NF7KOVVUSU6JRWK=
ZR-75-30 MmLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTF7LkC5Olgh|ryP MoLJV2FPT0WU
LU-135 M{TIfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTF7LkK2N|Yh|ryP MYnTRW5ITVJ?
NCI-H2029 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnuWGlRUUN3ME2xPU43ODJzIN88US=> NGjpPHdUSU6JRWK=
HT-1197 M4\KTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTF7LkmyNlch|ryP M1f3ZnNCVkeHUh?=
IGR-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTJyLkOxNVch|ryP NH\YblRUSU6JRWK=
U-87-MG M3K2cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfnfYtmUUN3ME2yNE43PDF|IN88US=> MkP6V2FPT0WU
NCI-H1304 NFeyW3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17wN2lEPTB;MkCuO|UxOSEQvF2= MkCwV2FPT0WU
RCC10RGB M3rQ[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfsdllwUUN3ME2yNU4zQDJ7IN88US=> NVv5bIZVW0GQR1XS
NCI-H520 NWrzdGFyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTt[2l4UUN3ME2yNk44PjFzIN88US=> MnfCV2FPT0WU
SK-LU-1 NVviSmV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjKTWM2OD1{Mz6wO|E5KM7:TR?= NGG3TFBUSU6JRWK=
UACC-893 NGjvOYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGG3PHFKSzVyPUKzMlExOzhizszN NFrzUVRUSU6JRWK=
NCI-H2347 NVG3OXhlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7GbW9uUUN3ME2yN{4zPjd2IN88US=> M2L4WXNCVkeHUh?=
U-118-MG MorrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzzRVNKSzVyPUKzMlczOTdizszN NVjRbXM2W0GQR1XS
NCI-H596 M17iUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PDbGlEPTB;MkOuPVA2PSEQvF2= NUS3VlJZW0GQR1XS
MZ1-PC MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTJ2Lk[3OVkh|ryP MXTTRW5ITVJ?
SW1417 NGTYdIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTJ3LkK0PVgh|ryP M{HUWHNCVkeHUh?=
NCI-H82 M1XUTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fzOWlEPTB;Mk[uOFI5QCEQvF2= NH\NVG5USU6JRWK=
COLO-678 NUSybIdtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HYdmlEPTB;MkeuOFkyQSEQvF2= NUjHb2hUW0GQR1XS
KURAMOCHI NWnLRVNuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDwWIxKSzVyPUK4MlEzPiEQvF2= MoK5V2FPT0WU
NCI-H1650 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEGzZ4VKSzVyPUOwMlE6OjRizszN M2XLPHNCVkeHUh?=
HCC1954 Ml\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjoNm5QUUN3ME2zNU4{PjZ4IN88US=> M3O3TXNCVkeHUh?=
GAK M17IcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTN{LkK2NVYh|ryP NEnR[YtUSU6JRWK=
YAPC M{TkN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXNZVFWUUN3ME2zN{44PjR6IN88US=> NYjHTGNTW0GQR1XS
NCI-H2228 M17tZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrzTWM2OD1|ND6zOlA2KM7:TR?= MleyV2FPT0WU
VMRC-RCZ MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnPTWM2OD1|Nj6zNFIzKM7:TR?= MlPiV2FPT0WU
NMC-G1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPDZoVkUUN3ME2zO{4xPTJ7IN88US=> MnTlV2FPT0WU
D-336MG NYnkdmZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHyNnFKSzVyPUSxMlg1PDJizszN MYTTRW5ITVJ?
UACC-62 NH3HRZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTyTWM2OD12Mj61OVA2KM7:TR?= NGXoTo9USU6JRWK=
C-33-A Mlq3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfSfmpKSzVyPUS1MlMzPTZizszN NWnESHRuW0GQR1XS
HCC1937 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTR5LkG5OVgh|ryP M3zmd3NCVkeHUh?=
HDLM-2 NVSye4U5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlf6TWM2OD12Nz6yNlg4KM7:TR?= M1vR[HNCVkeHUh?=
NCI-H727 M1;5Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDGblFKSzVyPUS3MlI1PTFizszN MVzTRW5ITVJ?
NY M4HTXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTR7LkO5NFgh|ryP NVjKTXJPW0GQR1XS
NCI-H2291 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLhTWM2OD12OT64N|AyKM7:TR?= M3zMRnNCVkeHUh?=

... Click to View More Cell Line Experimental Data
体内研究 Decitabine和Vorinostat都具有使肿瘤衰退的功能。然而, Decitabine 和 Vorinostat 联用使肿瘤衰退的效果更强。没有任何处理时,在野生型和Fasgld 小鼠中在肺肿瘤负担方面观察不到明显的区别。然而, Decitabine 和Vorinostat联用处理野生型小鼠，使肿瘤衰退比处理 Fasgld小鼠效果高很多。 Decitabine和Vorinostat使结肠癌细胞对FasL调节的肿瘤衰退敏感。低剂量Decitabine和Vorinostat处理，没有明显的肝脏毒性。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验：[4]
+ 展开

组蛋白去乙酰化酶活性测定:

为了进行 HDAC 实验24 × 104 dpm 乙醇溶液(1 mCi/ml)中提供的sup>3H-醋酸钠盐标记的组蛋白H4等份样, 加到每个试管中，试管中含悬浮在25 µL实验buffer(100 mM Tris-HCl pH 8, 2mM EDTA)中的200 µg全部HeLa细胞裂解液进行免疫沉淀获得的HDAC。加入不同浓度Vorinostat，在30oC下温育90分钟。加入20 µL 终止缓冲液(0.5 N HCl, 0.08 M AcOH)终止反应。加入0.8 mL TBME提取释放放入氚醋酸盐。在8,000 × g 转速下离心5分钟，600 µL 有机相(上相) 转移到包含3 mL闪烁液的闪烁瓶中。
细胞实验：[4]
+ 展开
  • Cell lines: NB4, NCI-H460和HCT-116肿瘤细胞系
  • Concentrations: 0 μM - 0.1 μM
  • Incubation Time: 48小时
  • Method: NB4, NCI-H460和HCT-116肿瘤细胞系生长在200 µL 96孔板中，约10%汇合，生长24小时后，覆盖孔中。使用多种浓度 Vorinostat或溶剂处理肿瘤细胞24小时。处理后，冲洗实验板，移除Vorinostat，温育48小时。使用sulphorodamine B 实验测定Vorinostat处理后存活细胞的分数。
    (Only for Reference)
动物实验：[3]
+ 展开
  • Animal Models: 携带CT26 细胞的Fasgld BALB/cByJ小鼠
  • Formulation: Dissolved in DMSO
  • Dosages: 25 mg/kg
  • Administration: 静脉注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 52 mg/mL (196.74 mM)
Ethanol 3 mg/mL (11.35 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)：
2% DMSO+30% PEG 300+5% Tween 80+ddH2O 		5mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 264.3
化学式

C14H20N2O3
CAS号 149647-78-9
稳定性 powder
in solvent
别名 SAHA, MK0683, suberoylanilide hydroxamic acid

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量：

总分子量：g/mol

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01281176 Active not recruiting Adult Solid Neoplasm National Cancer Institute (NCI) February 9 2011 Phase 1
NCT01189266 Active not recruiting Anaplastic Astrocytoma|Anaplastic Oligoastrocytoma|Brain Stem Glioma|Childhood Glioblastoma|Giant Cell Glioblastoma|Gliosarcoma|Untreated Childhood Anaplastic Astrocytoma|Untreated Childhood Anaplastic Oligoastrocytoma|Untreated Childhood Brain Stem Glioma|Untreated Childhood Giant Cell Glioblastoma|Untreated Childhood Gliosarcoma National Cancer Institute (NCI) August 9 2010 Phase 1|Phase 2
NCT00703664 Completed Recurrent Mantle Cell Lymphoma|Recurrent Non-Hodgkin Lymphoma National Cancer Institute (NCI) July 9 2008 Phase 2
NCT03198559 Suspended HIV Infections The Peter Doherty Institute for Infection and Immunity|Merck Sharp & Dohme Corp.|The Alfred|University of Melbourne August 8 2017 Phase 1|Phase 2
NCT02538510 Active not recruiting Head and Neck Squamous Cell Carcinoma|Recurrent Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma|Recurrent Nasopharynx Carcinoma|Recurrent Salivary Gland Carcinoma|Squamous Cell Carcinoma Metastatic in the Neck With Occult Primary|Stage III Major Salivary Gland Carcinoma|Stage III Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma|Stage III Nasopharyngeal Carcinoma|Stage IV Nasopharyngeal Carcinoma|Stage IVA Major Salivary Gland Carcinoma|Stage IVA Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma|Stage IVB Major Salivary Gland Carcinoma|Stage IVB Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma|Stage IVC Major Salivary Gland Carcinoma|Stage IVC Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma University of Washington|National Cancer Institute (NCI) October 8 2015 Phase 1|Phase 2
NCT01983969 Completed Advanced Cancers|Lymphoma M.D. Anderson Cancer Center November 7 2013 Phase 1|Phase 2

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操作手册

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  • * 必填项

常见问题及建议解决方法

  • 问题 1：

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • 回答：

    We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

Selleck产品目录册

HDAC Signaling Pathway Map

HDAC Inhibitors with Unique Features

相关HDAC产品

  • LMK-235 New

    LMK-235是HDAC4和HDAC5的选择性抑制剂， IC50分别为11.9 nM 和 4.2 nM。

  • CAY10603 New

    CAY10603是一种强效的选择性HDAC6抑制剂，IC50为2 pM，选择性比其它HDACs高200多倍。

  • 4SC-202 New

    4SC-202是一种选择性的I类HDAC抑制剂，对HDAC1，HDAC2，和HDAC3的IC50分别为1.20 μM，1.12 μM，和0.57 μM。也对Lysine specific demethylase 1 (LSD1)表现出抑制活性。Phase 1。

  • Panobinostat (LBH589)

    Panobinostat (LBH589)是一种新型的，广谱HDAC抑制剂，无细胞试验中IC50为5 nM。Phase 3。

  • Entinostat (MS-275)

    Entinostat (MS-275)强烈抑制HDAC1和HDAC3，无细胞试验中IC50分别为0.51 μM和1.7 μM，抑制作用强于HDACs 4， 6， 8，和10。Phase 3。

  • Trichostatin A (TSA)

    Trichostatin A (TSA)是一种HDAC抑制剂，无细胞试验中IC50为1.8 nM左右。

  • Romidepsin (FK228, Depsipeptide)

    Romidepsin (FK228, Depsipeptide)是一种有效的HDAC1和HDAC2抑制剂，无细胞试验中IC50分别为36 nM和47 nM。

    Features:Romidepsin对I型HDAC的抑制作用明显强于对II型HDAC的抑制。

  • RGFP966

    RGFP966是一种HDAC3抑制剂，无细胞试验中IC50为0.08μM ，比作用于其他HDAC选择性高200倍以上。

  • Tubastatin A

    Tubastatin A是一种有效的，选择性HDAC6抑制剂，无细胞试验中IC50为15 nM，选择性远高于所有其他同工酶(1000倍)除了HDAC8(57倍)。

  • Mocetinostat (MGCD0103)

    Mocetinostat (MGCD0103)是一种有效的HDAC抑制剂，对HDAC1抑制作用最强，无细胞试验中IC50为0.15 μM，比作用于HDAC2， 3，和11选择性高2到10倍，对HDAC4， 5， 6， 7，和8没有抑制活性。Phase 2。

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID