Vorinostat (SAHA, MK0683)

目录号：S1047 别名： SAHA, MK0683, suberoylanilide hydroxamic acid

Vorinostat (SAHA, MK0683) Chemical Structure

Molecular Weight(MW): 264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA)是一种HDAC抑制剂，无细胞试验中IC50为~10 nM。

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客户使用Selleck该产品发表文献103篇：

客户使用该产品的20个实验数据：

  • Activity of vorinostat in Jurkat and Peer T-ALL cell lines in an MTT cell viability assay. Cells were treated with increasing drug concentrations for 72 h. The data are plotted as the mean % of DMSO-treated control cells against the corresponding drug concentration. The error bars are the standard error. For each drug and cell line, 3-4 independent experiments were performed with 6 replicates at each drug concentration.

    Nature 2011 471, 235-9. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Differential effects of HDAC inhibitors on histone and tubulin acetylation. Immunofluorescence analysis of histone H3 (K9ac/K14ac) and tubulin acetylation in HeLa cells treated for 4 h with vehicle, SAHA (10 μM), tacedinaline (50 μM), PCI-24781 (20 μM. (a) Mapping of histone acetylation in K562 cells treated with HDAC inhibitors by LC-MS/MS. Cells were treated with TSA (10 μM), SAHA (5 μM), PCI-24781 (2 μM), tacedinaline (50 μM) for 6 h. Histones were extracted from cells and acetylated peptides were quantified after isobaric tagging.

    Nat Biotechnol 2011 29, 255-265. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Western blot analysis of histone H3 acetylation in the spleen of untreated and vorinostat-treated hNF-E2 tg mice (n = 4 of each genotype).

    J Exp Med 2012 209, 35-50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA down-regulates c-FLIP expression and increases the sensitivity of CaP cells to undergo apoptosis in the presence of bicalutamide (A) Bar graph illustrating the sub-G0/G1 cell population in 22Rv1 (left panel) and LNCaP (right panel) cells in the absence and presence of 10μM bicalutamide, administered as a single agent or in ombination with increasing concentrations of the HDAC inhibitor, SAHA. (B) Immunoblots demonstrating the single agent activity of bicalutamide or SAHA, or effect upon their combined administration on the expression of c-FLIP and/or the processing of PARP. Equal protein loading was confirmed by GAPDH. (C) Bar graph illustrating the effect of bicalutamide and SAHA upon the induction of caspase-8 or caspase-3/7 activity in 22Rv1 cells (left panel) and LNCaP cells (right panel). (D) Immunoblots characterizing the impact of SAHA and/or bicalutamide upon the induction of PARP cleavage, in the absence or presence of the pan-caspase inhibitor, ZIETD. ZIETD was incubated with the cells for 12 h prior to the experiment. All data points shown in (A) and (C) represent the mean ± S.E.M. value, calculated from four independent experiments.

    Clin Cancer Res 2012 18, 3822-33. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Analyses of efficacy, potency and IC50 of HDAC inhibitors point toward HDACs 1–3 as relevant candidates for beta cell protection. Ranking and raw data on ITF drugs (Table 3) and commercial HDAC inhibitors (Table 4) underlying the heat maps of Fig. 1 (A and B). The HDAC inhibitor compounds were tested using a HDAC activity kit and recombinant proteins to determine IC50 values on each individual HDAC (right part of the table). Each drug was further tested using Real-Time Cell Analysis (RTCA) to score their maximal effective concentration (ECmax) as well as the corresponding rescue percentage of cytokine treated INS-1 cells. The drugs were ranked according to % rescue. * DMSO alone controls were included in each experiment, but not shown here. The results indicate that the highest concentrations of DMSO used here (1:1,000) were slightly potentiating the proliferation of the cells. The effects observed in this group of compounds were ascribed to the DMSO.?

    Diabetologia 2012 55, 2421-2431. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Suberoylanilide hydroxyamic acid (SAHA) preserves CFP (+) expression in mouse optic nerves (MONs) from older mice. (a) CFP (+) mitochondria were longer and thicker in MONs from 12-month-old Thy-1 CFP mice (inset; scale bar = 2 μm). Oxygen–glucose deprivation (OGD) consistently reduced CFP pixel intensity in 12-month-old MONs despite longer and brighter CFP ( +) mitochondria (yellow arrows). (b) Blockade of AMPA/kain ate receptors with NBQX (30 μM), or pan-Histone deacetylase (HDAC) inhibition with SAHA (5 μM), effectively preserved CFP pixel intensity during OGD. The preservation of CFP (+) mitochondria correlates with protection of the CAP area during OGD and profound recovery.

    J Neurochem 2012 123 Suppl 2, 108-15. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • D and E, Regression of IL-13Ra 2-negative pancreatic tumors treated with SAHA and/or IL-13-PE. Mice were treated daily with i.p. injection of SAHA (25 mg/kg) from day 4 after tumor implantation for two weeks followed by i.t. injection of IL-13-PE (100 μ g/kg) from day 5 for two weeks. F and G, Regression of IL-13Ra 2-posotive pancreatic tumors (HS766T and MIA-PaCa2) treated with SAHA and/or IL-13-PE. The schedule of treatment was similar as in panel D and E. Statistical significances are shown by *: P < 0.05,†: P < 0.001.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

    IL-13Rα2 expression is upregulated in pancreatic tumors but not in organs of mice after treatment with HDAC inhibi tor, SAHA. A, qRT-PCR of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. Tumors were harvested next day after IL-13-PE treatment and total RNA extracted. Data shown is ratio of human IL-13Rα2/β-actin expression and multiplied by 1000 for convenience. Bars , SD of triplicate determinations. B, qRT-PCR of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Tissues were harvested at the same time point as in panel A and total RNA extracted. Data shown is ratio of mouse IL-13Rα2/β-actin expression and multiplied by 100 for convenience. C, IHC of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. D, IHC of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Liver, brain, kidney, pancreas, lung and spleen were fixed for immunostaining of mouse IL-13Rα2 as visualized by Alexa555. Nucleus was counterstained by DAPI.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Proliferation o f HT29 and HCT116 cells after 48 h of butyrate or SAHA treatment. Proliferation measurements using the xCEL Ligence RTCA DP instrument (Roche) in cells treated with increasing doses of butyrate or SAHA, compared with control medium cells (0) (*P < 0.05). The mean ?SEM of three cell culture replicates is shown.

    Mol Carcinog 2012 52, 459-74. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA induces the down-regulation of cFLIP expression and promotes TRAIL-mediated activation of a mitochondrial-operated apoptotic pathway. a BT-474 cells were treated as indicated in Fig. 1 and the cells were then harvested to analyse caspase-8, Bid, caspase-9, caspase-3 and PARP expression, using GAPDH as the protein loading control. b BT-474 cells were treated with SAHA for 8 h at the doses indicated and subsequently, the cells were harvested and the apoptosis-related proteins were analysed in western blots as described in the "Materials and Methods". The results shown are representative of at least three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Treatment with SAHA sensitizes breast cancer cells to TRAILinduced apoptosis. BT-474 and MDA-MB-231 cells were incubated for 8 h with SAHA at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some of the cultures for an additional 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content as described in the "Materials and methods". The results show the mean and S.E.M. of three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA facilitates the Itch/AIP4-independent proteasomal degradation of cFLIP proteins in breast cancer cells. a BT-474 cells were treated with SAHA (5 μM) for 8 h in the presence or absence of the proteasome inhibitors MG132 or epoxomicin (at the doses indicated), and they were then harvested and the cFLIP content was analysed in western blots. b BT-474 cells were transfected with either the siRNA oligonucleotides targeting Itch/AIP4 or the non-targeting RNA oligonucleotide (scrambled) for 48 h as described in the "Materials and Methods". Subsequently, the cells were treated with SAHA (5 μM) for 8 h and then cFLIP and Itch/AIP4 expression was analysed in immunoblots

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • cFLIP down-regulation following SAHA treatment is responsible for the sensitization of breast cancer cells to TRAIL. a BT-474 cells were transfected with either different siRNAs directed against the cFLIP isoforms or the non-targeting RNA oligonucleotide (scrambled) as described in the "Materials and Methods". After 24 h, the cells were treated with TRAIL (500 ng/ml) for a further 15 h and apoptosis was then measured as the percentage of cells with subG1 DNA content. The results show the mean and S.E.M. of three independent experiments. To verify protein knockdown, cells were harvested 24 h after transfection and the cFLIP levels were assessed in immunoblots. b. BT-474 cells overexpressing Cflipl (pBABE-FLIPL) or control cells (pBABE) were treated with SAHA for 8 h at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some cultures for 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content and the results show the mean and range of two independent experiments. Western blots show the cFLIP levels after SAHA treatment in pBABE and pBABE-FLIPL cells.

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Vorinostat inhibits the tumor growth. NOD ⁄ SCID-B2m-/-mice were injected s.c. with 1×106 MyLa2059 cells into both flanks. When the mice had developed established palpable tumors treatment was initiated (day 1). The mice received either vehicle (black line) or 60 mg ⁄ kg vorinostat (grey line) i.p. five days a week. In total, there were four mice in the group receiving vehicle and three mice in the group receiving vorinostat. The length and width of the tumors were measured continuously until the experiment was terminated on day 20 post treatment initiation. The tumor volume was calculated using the formula V = (a×b2)/2, where a defines the length (mm) and b the width (mm) of the tumor. The histogram shows the average tumor volume per flank ± SEM. * denotes a significant difference (P < 0.05) in the average tumor volume per flank between mice treated with vehicle and vorinostat at the given time-point both by using a one-tailed two samples test with Welch, scorrection and a Mann-Whitney U test.

     

     

    Exp Dermatol 2010 19, 1096-1102. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Western blot of whole cell extracts demonstrates SAHA and NaB treatment result in increased levels of acetylated histone H3 compared to vehicle controls. (b) Light micrographs of HDACi/vehicle treated cultures illustrate the paucity of neurospheres in HDACi-treated cultures. (c) Quantitative analysis confirms SAHA and NaB inhibit the formation of neurospheres (diameter ≥ 50 μm) and increase the prevalence of small cell clusters (≥ 4 cell, diameter < 50 μm). (d) Flow cytometry using LIVE/DEAD cell stain confirms SAHA and NaB are minimally toxic compared to vehicle controls (n = 3). Scale bar = 100 μm.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    (a) EdU flow cytometry of live cell-gated adult mouse NSCs demonstrates SAHA (**p < 0.01) and NaB (***p < 0.001) significantly inhibit DNA synthesis. (b) Analysis of DNA content by flow cytometry reveals significant accumulation of adult mouse NSCs in G1phase of the cell cycle following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (c) Correspondingly the proportion of cells in G2/M phase is significantly reduced following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (d) Fluorescence micrographs of HDACi/vehicle treated adult NSCs pulse-labeled with EdU for flow cytometry. Scale bar = 50 μm. Statistical comparisons performed using one-way ANOVA with post hoc Newman-Keuls multiple comparison tests.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Immunofluorescence labeling of NeuN, GFAP and Olig2 cell fate markers reveals reduced expression of GFAP (*p < 0.001) and Olig2 (*p < 0.05) in adult mouse NSCs treated with SAHA for 48 hours under proliferation culture conditions and then induced to differentiate for 14 days in culture (two-way ANOVA with Bonferroni post-tests). (b) Western blot of β-catenin protein in nuclear and cytoplasmic fractions of adult mouse NSCs treated with HDACi/vehicle control under proliferation culture conditions. Gapdh and lamin A/C blots are included as loading controls. (c) SAHA and NaB do not significantly alter nuclear/cytoplasmic levels of β-catenin in adult mouse NSCs. Histogram of β-catenin Western blot signal intensities normalized to loading controls (n = 4).

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Morphological changes and histone H3 phosphorylation of HB cells treated with a combination of VX-680 and SAHA. HUH6 and HepT1 were incubated with VX-680 (6 μM) and SAHA (0.5 μM). Nuclei diameter (a) and cell diameter (b) were determined 72 h later by DAPI staining and microscopy. Data represent mean±SD of the diameters from 20 cells in each experiment. (* Two-way ANOVA, Bonferroni test, p \0.05). c Western blot analysis on HUH6 and HepT1 cells were carried out with an anti-phospho-Histone H3 (Ser 10) antibody (p-H3) 24 h after incubation with VX-680 (10 μM), SAHA (0.2 μM) or a combination of both. Controls were left untreated. Western blot analysis showed a decrease in p–H3 after treatment with VX-680 ( lane 2 ) relative to controls ( lane 1 ) and an increase when SAHA was added ( lane 3 ). For the combination of VX-680 and SAHA (lane 4 ) no p-H3 was detected.

    Pediatr Surg Int 2012 28, 579-89. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Vorinostat promotes C2C12 differentiation.In the image, the red is the myotube indicating differentiation ,the blue is the nuclei.

     

     

    Dr. Akihiko Yoshimura of Akihiko Yoshimura. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Western blot analysis of Acetyl-H3 and H3. 0-20μM SAHA was added.

     

     

    Dr. Zhang of Tianjin Medical University. Vorinostat (SAHA, MK0683) purchased from Selleck.

产品安全说明书

HDAC抑制剂选择性比较

生物活性

产品描述 Vorinostat (suberoylanilide hydroxamic acid, SAHA)是一种HDAC抑制剂，无细胞试验中IC50为~10 nM。
特性 Vorinostat是广谱HDAC活性抑制剂，抑制I和II类酶 。
靶点
HDAC [1]
(Cell-free assay)
~10 nM
体外研究

Vorinostat是小分子量（<300）线性肟酸，抑制HDAC活性，包括乙酰化组蛋白和非组蛋白的积累，抑制培养细胞的增殖，且抑制肿瘤生长。Vorinostat通过结合到酶的活性位点而抑制 HDAC活性。Vorinostat 抑制多种转化细胞增殖（包括 淋巴瘤，多发性骨髓瘤，白血病，和非小细胞肺癌），与对照组相比抑制生长达50% 时的浓度为0.5 到10μM。Vorinostat作用于淋巴瘤和白血病细胞，包括 Burkitt, B-细胞急性淋巴细胞白血病 (B-ALL), MCL, DLBCL, ATL和T-细胞，不同程度抑制细胞增殖。除了抑制转化细胞增殖, Vorinostat 也抑制正常细胞增殖，通过比较Vorinostat 作用于一组细胞系–正常人非纤维细胞(WI-38)和 SV40巨大T抗原转化WI-38(VA-13细胞)而得到证明。Vorinostat 抑制两种类型细胞增殖，这种作用存在剂量依赖性。但发现Vorinostat 对转化细胞具有选择毒性，包括使肿瘤细胞死亡，而对正常细胞只起抑制作用，不会使其死亡。[1] Genistein 和Vorinostat 联用效果比5-aza和Vorinostat 联用作用于诱导细胞死亡有效很多。Genistein和Vorinostat联用作用于ARCaP-E使增殖降低 80 %，作用于ARCaP-M细胞，增殖降低60 %以上。Genistein和Vorinostat 联用抑制细胞增殖具有协同效应。作用于ARCaP-E 细胞(820个基因 诱导和1046个基因抑制) ARCaP-M 细胞，Vorinostat比Genistein 影响更多基因。[2] Vorinostat作用于肿瘤细胞表面，提高Fas蛋白水平，这种作用存在剂量依赖性，且按0.75 μM剂量处理，提高达到一个稳定水平。[3] Vorinostat 抑制肿瘤细胞生长，包括NB4, H460 和HCT-116，IC50分别为0.7μM, 3.4μM和1.2 μM。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 Mn7lT4lv[XOnIFHzd4F6 Mo\xNUBp MXzEUXNQ Ml;kZY51cS2KRFHDNUBi[3Srdnn0fUB4cXSqIFnDOVAhd2ZiMD6xNVIh|ryP NV;kbodnOTF7NkC0PFk>
Friend leukemic cell NGruRlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3n6bVUxKM7:TR?= NF72Tms4OiCq MmHISG1UVw>? NE\6UIhKSzVyPUCuPVkh|ryP MW[xNlExQTlzMx?=
K562 M3fX[2tqdmG|ZTDBd5NigQ>? NED2WnY3KGh? NGrIdnFFVVOR Mn7yTY5pcWKrdHnvckBw\iCqdX3hckBpcXO2b37lJIRm[WOndInsZZNmKCivaYj0eZJmKG:oIFjERWMyKGGwZDDISGFEOilid3n0bEBKSzVyIH;mJFAvODFizszN MWCxNlQyQTN6MB?=
HT1080 M1PtcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVm3NkBp NYTnN|BLTE2VTx?= MnHtTWM2OD1{LkSg{txO MWWxNlI4ODF5NR?=
H1299 MYLLbY5ie2ViQYPzZZk> M1vIdlIxKG2rbh?= MWPEUXNQ NFHlU4NKdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QhUESDQzDlcpp6dWVid3n0bEBKSzVyIH;mJFAvOTl2IN88US=> MmK0NVQ2OjF2MkK=
H1299 NXnUeppjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{OwclczKGh? MlPhSG1UVw>? M1:3c2lEPTB;Nz6yOEDPxE1? NGf2XXkyPDV{MUSyNi=>
HeLa M1XOfGtqdmG|ZTDBd5NigQ>? MVmzNEBucW5? NEnoRoNKdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gZYdicW6|dDDobZN1d26nIHTlZYNmfHmuYYPlJJdqfGhiSVO1NEBw\iByLkK4JO69VQ>? MUSxOVYxOzl2OR?=
LOX-IMVI M1TTUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\xOFghcA>? M3HPSGlEPTB;MT6zJO69VQ>? MXWxOVcyPTR5MB?=
NCI-H226 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPkOFghcA>? MUjJR|UxRTJwNjFOwG0> NIKzRpkyPTdzNUS3NC=>
RXF-631L Mn\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF76VI41QCCq NGi3TGhKSzVyPUKg{txO NYfPNll{OTV5MUW0O|A>
SNB-78 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvRSo5HPDhiaB?= MVfJR|UxRTF4IN88US=> NX7qcWpGOTV5MUW0O|A>
St-4 NHLRXI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHRcpM1QCCq NYPIbpBNUUN3ME21MlIh|ryP MVSxOVcyPTR5MB?=
ARP1 M1L6dmZ2dmO2aX;uJGF{e2G7 M1uxcVIh|ryP NXSzVWluPiCq MY\JcoR2[3Srb36gc4YhWDJzV1HGNUBo\W6nIHX4dJJme3Orb36= M4TuVlE1PzN2OEC2
CEM NXvGdVQxU2mwYYPlJGF{e2G7 MVGxJIg> M1;ic2ROW09? M13SRmlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD6zN{DPxE1? NEDrcpUyPjR{MEC2OC=>
HCT15 MorvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfvOFghcA>? MkjXS2k2OD1yLkiyJO69VQ>? MVmxOlczOzJ{Nx?=
NCI-H23 NIPCRmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUG0PEBp M2rjfGdKPTB;MD65NkDPxE1? MUCxOlczOzJ{Nx?=
GM15850 MUfLbY5ie2ViQYPzZZk> M{j0PFIvPSEQvF2= MVO5OkBp NIjyZnZFVVOR M{TFS2lvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFizJIx6e2mwZTCxOEBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= Mof3NVY6OjF|Nke=
GM15850 MlLPT4lv[XOnIFHzd4F6 M{jhNVIvPSEQvF2= MoTBPVYhcA>? MWTEUXNQ M2f0d2lvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTC1JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n MlrXNVY6OjF|Nke=
GM15850 MV;LbY5ie2ViQYPzZZk> NFnmTnIzNjVizszN NHPPZ3I6PiCq MoiySG1UVw>? NYLsbWs6UW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFEzKGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l MX6xOlkzOTN4Nx?=
GM15850 MW\LbY5ie2ViQYPzZZk> MVSyMlUh|ryP NILhemc6PiCq NGH5emhFVVOR Mln2TY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSEOgcJl{cW6nIEmgZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? Mo\KNVY6OjF|Nke=
GM15850 NFnaZlNMcW6jc3WgRZN{[Xl? MkTDNk42KM7:TR?= NYrhT2dzQTZiaB?= M3[2RWROW09? NX63NIJiUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFgh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NIW3S2oyPjl{MUO2Oy=>
GM15850 M3H1WWtqdmG|ZTDBd5NigQ>? NHKwfJozNjVizszN NX3QWm1jQTZiaB?= M1;tZmROW09? NV\lV4JHUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFE3KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l NF30VWcyPjl{MUO2Oy=>
U937 Ml;USpVv[3Srb36gRZN{[Xl? MkizOUDPxE1? NWjG[2ZNOjRiaB?= Mk\4SG1UVw>? MYHD[YxtKGO7Y3zlJIFzemW|dDDifUBi[2O3bYXsZZRqd25iYYSgV{9IOi:PIIDoZZNm Mn;KNVcxODR5MUi=
H661 NWjaRYNVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1f2fFQ5KGh? Mn\qTWM2OD1zIN88US=> MlzmNVcyPTdyMEm=
U937 M1TaS2Z2dmO2aX;uJGF{e2G7 NVXzfpZpPSEQvF2= Mor2NlQhcA>? M2DrVmROW09? M3S2bWlv[3KnYYPlJIlvKGirc4TvcoUhUDNiYXPleJlt[XSrb36= M1XUPFE4PDR5N{Ww
U937 NY\qb4FiTnWwY4Tpc44hSXO|YYm= MYixJO69VQ>? MX[yOEBp MUPEUXNQ NXi4RZEzTW[oZXP0JI9vKGGucHjhJJR2[nWuaX6gZYNmfHmuYYTpc44> NG\VZ3gyPzR2N{e1NC=>
RAW264.7 NY\ySJpLTnWwY4Tpc44hSXO|YYm= NVm3PFNWOTBizszN NEjFXVQzPGh? MVT3ZZRmeg>? MXjJcohq[mm2aX;uJI9nKEySUz3zeIlufWyjdHXkJHRPTmGucHjhJJBzd2S3Y4Tpc44hf2m2aDDJR|UxKG:oIECuO|Yh|ryP MXGxO|Q4PzVzOB?=
RAW264.7 MkLNSpVv[3Srb36gRZN{[Xl? MnuxNVAh|ryP NYL0c5NUOjSq M321NpdifGW{ M4LVeWlvcGmkaYTpc44hd2ZiTGDTMZN1cW23bHH0[YQhVk9icILv[JVkfGmxbjD3bZRpKEmFNUCgc4YhOS56ODFOwG0> MVyxO|Q4PzVzOB?=
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Primary bronchial epithelial cell Mn\ET4lv[XOnIFHzd4F6 MUG1JO69VQ>? NWDkW|J{OjRiaB?= NHjzTIhFVVOR MUPJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6mdXP0bY9vKG:oIH31eIFvfCCIZHXseIE2ODhiQ1\UVkBxem:2ZXnuJIFxcWOjbDDzeZJn[WOnIHzvZ4FtcXqjdHnvci=> NVL5Tm1qOTl7Nk[3PFk>
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BxPC3 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI[0UpY4OiCq NELxfHZKSzVyPUKuO{DPxE1? MV[yNFE1Ozd5OB?=
CAL27 NV7LZYU5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUm3NkBp MV;JR|UxRTNwN{Kg{txO MYOyNFE1Ozd5OB?=
Capan1 MlXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUK3NkBp MU\JR|UxRTdwMzFOwG0> M{LQc|IxOTR|N{e4
HCC827 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUG3eJRbPzJiaB?= MmW3TWM2OD1zLkig{txO MWKyNFE1Ozd5OB?=
LNCAP NWnvNWw3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFL5NmQ4OiCq MWHJR|UxRTBwNUig{txO M4rLWlIxOTR|N{e4
NCI-H2122 NX3hdHlNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\HUnBjPzJiaB?= Mn22TWM2OD15LkWg{txO M1PudlIxOTR|N{e4
NCI-H358 NUP5VJdqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHWW4l4PzJiaB?= MX3JR|UxRTJwNTFOwG0> NWfOfpp5OjBzNEO3O|g>
SCC15 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWi3NkBp M17QOGlEPTB;Mj60PUDPxE1? M2O5ZVIxOTR|N{e4
SCC25 MnT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfZfXI4OiCq MmPFTWM2OD1zLkmzJO69VQ>? NITTeXYzODF2M{e3PC=>
SKHEP1 NGHZU4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2ftOFczKGh? MVXJR|UxRTNwNE[g{txO MVOyNFE1Ozd5OB?=
BJ M1Lhb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\mNVExOCEQvF2= NVPyW4c5PDhiaB?= MYfEUXNQ Mof3S5Jwf3SqIHnubIljcXSrb36gZZQhOC5yNTD0c{AyODBidV2= M4HYN|IxOTR|OESw
MUF MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHGNId3OTByIN88US=> MnjUOFghcA>? Mn76SG1UVw>? NFjicXhIem:5dHigbY5pcWKrdHnvckBifCByLkC1JJRwKDFyMDD1US=> MVmyNFE1Ozh2MB?=
Caco-2 NGrTXJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYOxNFAh|ryP MYm0PIg> MYDEUXNQ NVrqWHlPUUN3ME24MlEh|ryP NV[4T5dROjBzNEO4OFA>
Caco-2 NX;DfY9QU2mwYYPlJGF{e2G7 NFfjZm02KM7:TR?= NUTNUINXPCCq MWnEUXNQ MofRTY5lfWO2aX;uJI9nKEiGQVOtcYVlcWG2ZXSgbIl{fG:wZTDhZ4V1gWyjdHnvckBKSzVyIH;mJFAvODN5IN88US=> MVKyNFE1Ozh2MB?=
Caco-2 MXXLbY5ie2ViQYPzZZk> MVmwMlMyPiCwTTD0c{A{OS54IN88US=> MX[0JIg> MmT3SG1UVw>? MVTFfEB3cX[xIHnubIljcXSrb36gc4YhcHWvYX6gTGRCSzFid3n0bEBKSzVyIH;mJFAvOTF7IN88US=> NWDtOG95OjBzNEO4OFA>
Caco-2 NWjUTmdZU2mwYYPlJGF{e2G7 NULibGgxOC5|MU[gcm0hfG9iM{GuOkDPxE1? M3LjUVQhcA>? Ml7oSG1UVw>? M3:0ZmV5KH[rdn:gbY5pcWKrdHnvckBw\iCqdX3hckBJTEGFMzD3bZRpKEmFNUCgc4YhOC5zNEeg{txO M3zQdlIxOTR|OESw
Caco-2 MXzLbY5ie2ViQYPzZZk> Mn3qOk4{OiCwTTD0c{A3OzJizszN NIXrOog1KGh? NHLQd4dFVVOR NEPh[FVGgCC4aY\vJIlvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{Wge4l1cCCLQ{WwJI9nKDF{Lk[g{txO M1L4NFIxOTR|OESw
Caco-2 NEO4bmJMcW6jc3WgRZN{[Xl? NUHxOoVqPi5|MjDuUUB1dyB4M{Kg{txO NH\hUmM1KGh? MXvEUXNQ MXfFfEB3cX[xIHnubIljcXSrb36gc4YhcHWvYX6gTGRCSzdid3n0bEBKSzVyIH;mJFQyKM7:TR?= MXKyNFE1Ozh2MB?=
Caco-2 M4LjdWtqdmG|ZTDBd5NigQ>? MlK0NE4{OTZibl2geI8hOzFwNjFOwG0> MoPvOEBp M4fvZmROW09? M{nxNmV5KH[rdn:gbY5pcWKrdHnvckBw\iCqdX3hckBJTEGFNh?= MnvGNlAyPDN6NEC=
HepG2 NFTjeG9McW6jc3WgRZN{[Xl? MVy1JO69VQ>? NFPCXlg3cA>? MVzEUXNQ MU\JcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDobZN1d26nIHHj[ZR6dGG2aX;u NYq2fZZNOjBzNEO4OFA>
HepG2 MVTLbY5ie2ViQYPzZZk> NXXJdIFwPSEQvF2= MorxOog> NX;mb2pITE2VTx?= MX3JcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDobZN1d26nIHj5dIVz[WOndInsZZRqd25? M2HPd|IxOTR|OESw
HepG2 NV3re|VyU2mwYYPlJGF{e2G7 MVq1JO69VQ>? Ml3LOog> NVS0U5J[TE2VTx?= NVf0fHQyUW6mdXP0bY9vKG:oIFjERWMudWWmaXH0[YQh[WyyaHGteJVjfWyrbjDhZ4V1gWyjdHnvci=> MYeyNFE1Ozh2MB?=
HepG2 MVTLbY5ie2ViQYPzZZk> M1rVeVUh|ryP MorsOog> MorkSG1UVw>? MmewTY5lfWO2aX;uJI9nKEiGQVOtcYVlcWG2ZXSgTFMwUDRiaHnzeI9v\SCjY3X0fYxifGmxbh?= MVqyNFE1Ozh2MB?=
COLO205 M3;Rd2tqdmG|ZTDBd5NigQ>? NICyfHEyOCEQvF2= MUKyOEBp NVvtd5EyTE2VTx?= M1jtZWlvcGmkaYTpc44hd2ZiSFTBR|Eh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJIhqe3SxbnWgTFMh[WOndInsZZRqd25id3n0bEBKSzVyIH;mJFIvOiEQvF2= NILMVXQzODR3MUO3PC=>
SCC4 Mlr4T4lv[XOnIFHzd4F6 M2H4UVEh|ryP NWfDSpd1OjSq MoTmTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIIT1ZpVtcW5iYXPleJlt[XSrb36= MY[yNFQ2OjJ{NR?=
SCC4 NIHmXolMcW6jc3WgRZN{[Xl? MWCxJO69VQ>? NVvRblhpOjSq M1HBSGlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIHHj[ZR6dGG2aX;u Mln0NlA1PTJ{MkW=
SCC4 NYDXdlJOTnWwY4Tpc44hSXO|YYm= MUKxJO69VQ>? M1H1dlUhdWmw NH32SolC\2:waYP0JIFkfGm4aYT5JIF1KF[GUjDhd5Nme3OnZDDhd{BqdmS3Y4Tpc44hd2ZiQ2nQNlQh\2WwZTDlfJBz\XO|aX;u M1LlPVIxPDV{MkK1
NB4 M1LsOmZ2dmO2aX;uJGF{e2G7 NV3jOGtvPSEQvF2= MnXsNlQhcA>? NVHvNFh[TE2VTx?= MojXR4VtdCCleXPs[UBienKnc4SgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iYXPjeY12dGG2aX;uJIF1KHC{ZT3HNUBxcGG|ZR?= MkHWNlA1QTF2NEC=
NB4 NHTDXmhMcW6jc3WgRZN{[Xl? MVG1JO69VQ>? NWHk[2t5OjRiaB?= MYHEUXNQ NIe3fWtKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gZYNmfHmuYYTlJJR2[nWuaX6gcIV3\Wx? Ml:zNlA1QTF2NEC=
NB4 MlfmSpVv[3Srb36gRZN{[Xl? MXW1JO69VQ>? NVLKe5QxOjRiaB?= MVnEUXNQ NUT3fohzUW6mdXP0bY9vKG:oIICyNXdCTjFxQ1nQNUBmgHC{ZYPzbY9v NHH6b5UzODR7MUS0NC=>
NB4 NWrxSHJNU2mwYYPlJGF{e2G7 M1XVbFUh|ryP MVeyOEBp NFTXcVNFVVOR NXTzWXJJUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMh[WOndInsZZRqd25? MYCyNFQ6OTR2MB?=
NUGC3 M2XPbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\LS2k2OD1{Lkm0JO69VQ>? NXvmR5dZOjB6NUC5O|E>
A549 NEDuVHdHfW6ldHnvckBCe3OjeR?= NYHSfmtoPSEQvF2= Mn7SN{Bp Mn;RSG1UVw>? NWPFN|dEUW6mdXP0bY9vKG:oIHH1eI9xcGGpeTDpckBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIFzDN2lK MVqyNFg2PTJyOB?=
HUT78 NIPGSIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vIeFczKGh? NH22TIhFVVOR NVHwO3h1T0l3ME2wMlMh|ryP NHPFb4QzODh6NEKwPC=>
U937 NHrKd5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVyz[G9TPzJiaB?= NE\3T|FFVVOR NFjvUXpIUTVyPUCuN|kh|ryP M{H5ZlIxQDh2MkC4
A431 MXLDfZRwfG:6aXOgRZN{[Xl? Mlj4O|IhcA>? MlLOR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVQ{OSClZXzsd{BwfmW{ZYjwdoV{e2mwZzDFS2ZTKHerdHigTWM2OCCxZjC0MlIh|ryP M1GyN|IyODhyNkK5
A549 MlvpR5l1d3SxeHnjJGF{e2G7 NFfQZoY4OiCq MYPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJI93\XKneIDy[ZN{cW6pIFjERWMhf2m2aDDJR|UxKG:oIEGuPEDPxE1? Mo\FNlExQDB4Mkm=
CAL27 M2frcWN6fG:2b4jpZ{BCe3OjeR?= MmjtO|IhcA>? NE[3RohEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBESUx{NzDj[YxteyCxdnXy[ZhxemW|c3nu[{BGT0[UIIfpeIghUUN3MDDv[kA{NjJizszN MVqyNVA5ODZ{OR?=
HeLa NXnk[4tZS3m2b4TvfIlkKEG|c3H5 NUjXNGh1PzJiaB?= NYfrXVZuS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCxdnXy[ZhxemW|c3nu[{BJTEGFIIfpeIghUUN3MDDv[kAyNjVizszN M{PxXVIyODhyNkK5
Sf21 NXLTbGc3U2mwYYPlJGF{e2G7 MnvaN{Bp NETLUXVKdmirYnn0bY9vKG:oIF\sZYchfGGpZ3XkJIh2dWGwIILlZ49u[mmwYX70JGhFSUN6IHX4dJJme3OnZDD3bZRpKEmFNUCgc4YhOS5{IN88US=> MWWyNVA5ODZ{OR?=
SKBR3 MYPDfZRwfG:6aXOgRZN{[Xl? NFXpfmI4OiCq MnLFR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2tDWjNiY3XscJMhd3[ncnX4dJJme3OrbnegTGVTOiC5aYToJGlEPTBib3[gNk43KM7:TR?= M37ieFIyODhyNkK5
SKOV3 NH\jd4dEgXSxdH;4bYMhSXO|YYm= NWm0XVExPzJiaB?= NU\F[WFjS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0uRVkOgZ4VtdHNib4\ldoV5eHKnc4PpcochUEWUMjD3bZRpKEmFNUCgc4YhOi5{IN88US=> NHjZXoQzOTB6ME[yPS=>
COR-L23 MlzvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVyxNEDPxE1? M3;RfFczKGh? NVj2SotsTE2VTx?= MnTDS2k2OD1zLkGg{txO M1;YUVIyODhyNkS3
DU145 MlvPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXW[3M5OTBizszN NUnrTml6PzJiaB?= MkO0SG1UVw>? NYn1NlcxT0l3ME2xMlA2KM7:TR?= M1;CblIyODhyNkS3
LoVo Mme3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHa[oVUOTBizszN MlKxO|IhcA>? MWXEUXNQ MmT3S2k2OD1zLkeg{txO NHjsOm0zOTB6ME[0Oy=>
MCR5-SV2 MorRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4izXlExKM7:TR?= MXO3NkBp M1fHUGROW09? MnKxS2k2OD1{LkGg{txO NV;OeWtEOjFyOEC2OFc>
HCT116 Mn\nT4lv[XOnIFHzd4F6 MUezNEDPxE1? NWfabVk3OzBiaB?= MonrSG1UVw>? M37ZOmlvcGmkaYTpc44hd2ZiSFTBR|Yh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJIFteGijLYT1ZpVtcW5iYXPleJlt[XSrb36= NUfWUG4xOjFyOEC2OFc>
HCT116 MkPuT4lv[XOnIFHzd4F6 MoXMN|Ah|ryP MnTsN|AhcA>? M33wTGROW09? M3\jTmlvcGmkaYTpc44hd2ZiSFTBR|Eh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJIhqe3SxbnWgTFNMQSCjY3X0fYxifGmxbh?= NXH2NolLOjFyOEC2OFc>
U937 M{jrUmtqdmG|ZTDBd5NigQ>? NYi0dnVDPSEQvF2= MYeyOEBp MX\EUXNQ MoLNTY5pcWKrdHnvckBw\iCqaYP0c45mKGGlZYT5cJRz[W6|ZnXyZZNmKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIH;mJIFk\XS7bHH0bY9vKG:oIHjpd5RwdmViSEOgZZQhUzl? MonDNlEzQTJ2OUK=
U937 MUXLbY5ie2ViQYPzZZk> NEPOelQ2KM7:TR?= NF72fZgzPCCq MVXEUXNQ NF;2OnhKdmirYnn0bY9vKG:oIHjpd5RwdmViYXPleJltfHKjboPm[ZJie2ViYYPz[ZN{\WRiYYOgbY5kemWjc3Wgc4Yh[WOndInsZZRqd25ib3[gbIl{fG:wZTDIN{BifCCNMUi= NGTxSo4zOTJ7MkS5Ni=>
U937 MnfFT4lv[XOnIFHzd4F6 NF;wTGg2KM7:TR?= MUKyOEBp MUPEUXNQ NX7CW3ZGUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKHCjbj3hZ4V1gWyjdHXkJIhqe3SxbnWgTFQhdGW4ZXy= MlXpNlEzQTJ2OUK=
U937 NUPIPIprU2mwYYPlJGF{e2G7 MmG2OUDPxE1? M2rKUlE2KG2rbh?= M33p[2ROW09? Mo[wTY5pcWKrdHnvckBw\iCqaYP0c45mKGGlZYT5cJRz[W6|ZnXyZZNmKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIH;mJIhqe3SxbnWgTFMh[WOndInsZZRqd25ibHX2[Yw> MoGwNlEzQTJ2OUK=
A2780 NYrU[|lsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWm4dJNbQTZiaB?= NIH5[ZZFVVOR NH\LcllKSzVyPUGuOlIh|ryP MX[yNVY{PDR|MB?=
COLO205 MlnaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3z3WFk3KGh? MoXWSG1UVw>? NXm4VZZuUUN3ME2yMlEzKM7:TR?= NHK4O4IzOTZ|NESzNC=>
Hep3B NGf5dHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPrXHdxPDhiaB?= M1;JcWROW09? NVzi[GZkT0l3ME2xMlIyKM7:TR?= NYrkUHBmOjF5MUKxOFY>
GM11272 NXOyRm4yTnWwY4Tpc44hSXO|YYm= NIn6e3QyODBibl2= Mn\3O|IhcA>? MYrEUXNQ M364[nJm[WO2aY\heIlwdiCxZjDN[WNxOiCvdYThcpQh\XiycnXzd4lwdiCjdDCxNEB1dyBzMECgcm0> MnjoNlE5PDB5MU[=
CFBE41o MVnLbY5ie2ViQYPzZZk> M4TvT|Uh|ryP M4[4bWROW09? MXrEc5dvKHKnZ4XsZZRqd25ib3[gTGRCSzdiYYSgNE4zKHSxIEWgeW0> M3vLSFIyQTh2OUW4
CFBE41o NYHibZF5TnWwY4Tpc44hSXO|YYm= NXqzW5FSOSEQvF2= NIjDVW0zPCCq MnHuSG1UVw>? MVXS[ZN1d3KjdHnvckBw\iCFRmTSJIRmdHSjRkWwPEBufXSjboSgeJJi\m[rY3vpcochfG9iY3XscEB{fXKoYXPlJIF{KGeueXPv[o9zdXN? Mof2NlE6QDR7NUi=
DU145 NWewR4hHU2mwYYPlJGF{e2G7 MlXrNk42KM7:TR?= MVeyOEBp MVfEUXNQ NXvlNFkxUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IIXwdoVofWyjdHnvckBw\iCyMkH3ZYYyKHC{b4TlbY4h\XiycnXzd4lwdg>? NUPHTJFZOjJ{NkCxOlY>
DU145 NXvMV5R[U2mwYYPlJGF{e2G7 Ml\NOUDPxE1? M3LkblI1KGh? NE\ub2dFVVOR M3fwSGlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCqaYP0c45mKEh2IHHj[ZR6dGG2aX;u MYeyNlI3ODF4Nh?=
DU145 NWXrcW1ZU2mwYYPlJGF{e2G7 M3GxWVUh|ryP M2\wUlI1KGh? M4P0ZWROW09? NIXJWlhKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaHnzeI9v\SCKMzDofZBmemGlZYT5cIF1cW:w MW[yNlI3ODF4Nh?=
786-0 NG\JN45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXy4VHdNPi5{IN88US=> MoTKO|IhcA>? MnzQSG1UVw>? NH;aVVlIUTVyPUOuNkDPxE1? NIjscpkzOjR|NU[2PS=>
A498 M2T6Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWe2MlIh|ryP MofTO|IhcA>? NF7QR4ZFVVOR MX3HTVUxRTFwNjFOwG0> NX;Ie2VjOjJ2M{W2Olk>
A549/ATCC MnfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vBfVYvOiEQvF2= MXG3NkBp NWPJbGYxTE2VTx?= NYnic4QzT0l3ME2xMlYh|ryP M{T1RlIzPDN3Nk[5
ACHN NWTtU3RFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\SRpVZPi5{IN88US=> MWK3NkBp Ml;2SG1UVw>? M123RWdKPTB;MT6zJO69VQ>? MX2yNlQ{PTZ4OR?=
BT549 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zWWlYvOiEQvF2= MVi3NkBp M2rCNGROW09? MUTHTVUxRTFwMzFOwG0> NV72bHhjOjJ2M{W2Olk>
EKVX MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPkPFF3Pi5{IN88US=> MWq3NkBp M{X6VWROW09? NXvSfGxXT0l3ME2xMlMh|ryP NYS1d4h{OjJ2M{W2Olk>
HCT15 MnXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV[2MlIh|ryP NV7uZ4s6PzJiaB?= MVjEUXNQ MYTHTVUxRTJwNTFOwG0> NEXmdJIzOjR|NU[2PS=>
HOP92 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWK2MlIh|ryP MoHpO|IhcA>? Ml3YSG1UVw>? MVHHTVUxRTRizszN NWPkXJNpOjJ2M{W2Olk>
IGROV1 NV3XTYRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHGe4c3Pi5{IN88US=> MkT0O|IhcA>? NGLS[YZFVVOR MnXqS2k2OD1zLkOg{txO MmO3NlI1OzV4Nkm=
LOXIMVI NYW5UpRmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHniSo03NjJizszN MmXnO|IhcA>? M3y5emROW09? M1ntW2dKPTB;MTFOwG0> NEPod20zOjR|NU[2PS=>
M14 NUfpXldkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTXOk4zKM7:TR?= MoXjO|IhcA>? M1PpRWROW09? MmryS2k2OD1zLkOg{txO M3\H[VIzPDN3Nk[5
MALME-3M NGKyZndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13acFYvOiEQvF2= M{G3W|czKGh? NWSxcI9PTE2VTx?= MY\HTVUxRTBwM{Kg{txO MWmyNlQ{PTZ4OR?=
MCF10A MkTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHBZXI3NjJizszN M2rPUFQ5KGh? M1[5R2ROW09? NGXsT|FIUTVyPUmuOkDPxE1? M{HSVVIzPDN3Nk[5
MDA-MB-435 M2T2U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkL3Ok4zKM7:TR?= MkPkO|IhcA>? MWjEUXNQ M1\0SmdKPTB;MD61JO69VQ>? M1WyO|IzPDN3Nk[5
MDA-MB-468 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\rOk4zKM7:TR?= NXTlepR2PzJiaB?= NXvaV4JNTE2VTx?= NIHGZ3pIUTVyPUCuOlMh|ryP NXnVXoJvOjJ2M{W2Olk>
MOLT4 NHLZWZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M136O|YvOiEQvF2= M1z2elczKGh? NG\YVW1FVVOR MnfpS2k2OD1yLkSg{txO MnLmNlI1OzV4Nkm=
NCI-ADR-RES NFzOOWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPnWXg3NjJizszN Ml\OO|IhcA>? M{LYNmROW09? MUTHTVUxRTBwMU[g{txO M{nUPFIzPDN3Nk[5
NCI-H23 MlPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXlOk4zKM7:TR?= NXLoPGVUPzJiaB?= M2exVmROW09? MlzRS2k2OD1zIN88US=> MonONlI1OzV4Nkm=
NCI-H322M MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXW2MlIh|ryP M2XWb|czKGh? Ml\USG1UVw>? M2\Nc2dKPTB;MD63PUDPxE1? M3vwe|IzPDN3Nk[5
NCI-H460 NYPQR25{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13mPVYvOiEQvF2= MlywO|IhcA>? NHrs[HRFVVOR MVHHTVUxRTBwN{mg{txO NF24ZnAzOjR|NU[2PS=>
NCI-H522 NIjCVIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\2Ok4zKM7:TR?= NG\JUm04OiCq NH\MR2VFVVOR MXnHTVUxRTBwNTFOwG0> MlvjNlI1OzV4Nkm=
OVCAR3 MkPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;5Ok4zKM7:TR?= NFm0O|I4OiCq Mk[3SG1UVw>? NH\ZdYlIUTVyPUGuN{DPxE1? MXiyNlQ{PTZ4OR?=
OVCAR4 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUe2MlIh|ryP MU[3NkBp M4T1[mROW09? MkO1S2k2OD12IN88US=> M{j6PFIzPDN3Nk[5
OVCAR5 M{e0OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjQdVQ3NjJizszN MlT1O|IhcA>? MUXEUXNQ MVHHTVUxRTBwN{mg{txO NXPhWo8{OjJ2M{W2Olk>
OVCAR8 NEDON4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVO2MlIh|ryP MlL5O|IhcA>? NGjZR5hFVVOR M1n6UGdKPTB;MD61JO69VQ>? NVTtZ5J7OjJ2M{W2Olk>
RXF393 NVf6XFVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHVOk4zKM7:TR?= NFnlfWY4OiCq M1LyXGROW09? NVfXSpJRT0l3ME2xMlMh|ryP NHTCNHUzOjR|NU[2PS=>
SF268 M3zG[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonvOk4zKM7:TR?= M3fVR|czKGh? NF;iWZFFVVOR NV;mUm5iT0l3ME2xMlYh|ryP NEflc28zOjR|NU[2PS=>
SF295 NF7rO5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7VOk4zKM7:TR?= MVy3NkBp NU\lSW83TE2VTx?= NVvsW2I4T0l3ME2xMlYh|ryP NUDSU|JkOjJ2M{W2Olk>
SF539 M1nqOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITRUFI3NjJizszN NEPqflk4OiCq NEe0[XJFVVOR MnrLS2k2OD1{IN88US=> M{LaVlIzPDN3Nk[5
SK-MEL-2 NWTKXodFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;aWFYvOiEQvF2= MYe3NkBp MmPOSG1UVw>? NEDTTGtIUTVyPUGuN{DPxE1? MkT6NlI1OzV4Nkm=
SK-MEL-28 NGXVUGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXO2MlIh|ryP NUPaSFF7PzJiaB?= NYnZS3o2TE2VTx?= M3mzTGdKPTB;MTFOwG0> MonENlI1OzV4Nkm=
SK-MEL-5 NILHe4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LGWlYvOiEQvF2= NH;tOFM4OiCq NETxfHhFVVOR NFLHTphIUTVyPUCuOlMh|ryP NUPye3pKOjJ2M{W2Olk>
SKOV3 MkP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3Xle|YvOiEQvF2= NFPSbZU4OiCq M3HGZ2ROW09? NUHX[IJST0l3ME2xJO69VQ>? M4PlUlIzPDN3Nk[5
SN12C MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH73enU3NjJizszN M3vj[FczKGh? Mm\HSG1UVw>? MVvHTVUxRTJizszN MXqyNlQ{PTZ4OR?=
SNB19 NHnSS2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfLfnJWPi5{IN88US=> NFvCeFA4OiCq NUnyPIkzTE2VTx?= M2XFRmdKPTB;MD62N{DPxE1? M4LHNVIzPDN3Nk[5
SNB75 NHzyfYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Lp[VYvOiEQvF2= MmDIO|IhcA>? MY\EUXNQ NWHFdIUyT0l3ME2wMlc6KM7:TR?= Mkm3NlI1OzV4Nkm=
SR NES4TVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW[2MlIh|ryP MoHRO|IhcA>? MUHEUXNQ Mlj2S2k2OD1yLkSg{txO MlzINlI1OzV4Nkm=
T47D NWPRPIpkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXEdmpmPi5{IN88US=> NXXJbVEyPzJiaB?= NUOzO|R[TE2VTx?= MWTHTVUxRTBwNTFOwG0> M1rkNFIzPDN3Nk[5
TK10 M3\F[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVu2MlIh|ryP M1LyVFczKGh? MWHEUXNQ NHzISotIUTVyPUCuOlMh|ryP M3n5VFIzPDN3Nk[5
UACC257 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfEU|IzPi5{IN88US=> NHvDeFg4OiCq M2PRWmROW09? MV3HTVUxRTBwNTFOwG0> M4XFRlIzPDN3Nk[5
UACC62 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF6zSZU3NjJizszN NF32NYs4OiCq MnnNSG1UVw>? MXzHTVUxRTBwNDFOwG0> MVmyNlQ{PTZ4OR?=
UO31 MmCyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TZVlYvOiEQvF2= MlXSO|IhcA>? NEDySYNFVVOR MWjHTVUxRTBwNTFOwG0> NYfIO5BCOjJ2M{W2Olk>
Hep3B MoraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYC0PEBp MoD6SG1UVw>? M3TPWWdKPTB;MD62PUDPxE1? Mn3WNlI1Ozl6NkO=
BE(2)-C MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLIO|IhcA>? MUDEUXNQ MlHJTWM4OD1{IN88US=> NGPPXHgzOjl|MkOxOi=>
Bel7402 NXn1S29bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGflR4c4OiCq NU[3b4dvTE2VTx?= NY\wcI5VT0l7ME2xO{DPxE1? MYiyN|A3OTN5Nh?=
Bel7404 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUK3NkBp NYP5bY8xTE2VTx?= M3zaemdKQTB;MUig{txO NXr4Rmw4OjNyNkGzO|Y>
BGC823 NYmzelk5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGP3UlA4OiCq MW\EUXNQ NGnrZ4ZIUTlyPUeuOUDPxE1? MnziNlMxPjF|N{[=
MGC803 NYri[m92T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXK3NkBp M2nOZWROW09? M{jieGdKQTB;MUCuPEDPxE1? MVOyN|A3OTN5Nh?=
SGC7901 NV3YXGVTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\I[|czKGh? NEDoWlNFVVOR Ml:2S2k6OD17LkSg{txO MlqxNlMxPjF|N{[=
SKHEP1 NFmydmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfC[2c2PzJiaB?= NIPrdYNFVVOR M3H3fWdKQTB;MUeg{txO Mn7LNlMxPjF|N{[=
SMMC7721 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjNdZV7PzJiaB?= MmPWSG1UVw>? MYTHTVkxRTJyIN88US=> NHrkTIMzOzB4MUO3Oi=>
NUGC3 NYPm[VVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3IWIEyOCEQvF2= NHG5Z|dIUT1{Lkm0JO69VQ>? MUKyN|E3OzN|Mh?=
A2780 CisR M{HZ[WtqdmG|ZTDBd5NigQ>? MV2xPEBp M3\jWGlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD60OEDPxE1? M1G1VFI{OjV{NkCz
CAL27 sens MmDET4lv[XOnIFHzd4F6 M4nZPVE5KGh? MkDDTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkO2JO69VQ>? NY\3bnZoOjN{NUK2NFM>
CAL27 CisR NWe0[ZpKU2mwYYPlJGF{e2G7 NXXVdo1kOThiaB?= MXjJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNkGg{txO NUe4WlcxOjN{NUK2NFM>
KYSE-510 CisR MWnLbY5ie2ViQYPzZZk> MnHiNVghcA>? NGDuNJlKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOVkh|ryP MoLONlMzPTJ4MEO=
KYSE-510 sens MYjLbY5ie2ViQYPzZZk> NUf5[W5iOThiaB?= NHjwRldKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuO{DPxE1? MnvUNlMzPTJ4MEO=
MDA-MB-231 sens MX\LbY5ie2ViQYPzZZk> NGPhc24yQCCq MWfJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNkGg{txO M1z4eFI{OjV{NkCz
MDA-MB-231 CisR NXPhTFhbU2mwYYPlJGF{e2G7 NX\ZS5ZQOThiaB?= NXnsNlZyUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlYyKM7:TR?= Mm\iNlMzPTJ4MEO=
ES2 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXe0PEBp M3PRRWROW09? NVLpc3hiUUN3ME2xNk44KM7:TR?= MUCyN|Q6OzR2OR?=
MDA-MB-231 NH7PNFFMcW6jc3WgRZN{[Xl? NEXUflIyOCEQvF2= MWezNEBucW5? MV7EUXNQ MkCyTY5pcWKrdHnvckBw\iCKRFHDNoE> M2DYNFI{PDl|NES5
MDA-MB-231 NVjPVGRKU2mwYYPlJGF{e2G7 MnfXNUDPxE1? M2HvS|I1KGh? NXHnR|BXTE2VTx?= MVzJcohq[mm2aX;uJI9nKEiGQVO2JIF{e2W|c3XkJIF{KGGlZYT5cIF1cW:wIHzleoVteyCxZjD0eYJ2dGmw NUmzdpN7OjN2OUO0OFk>
HS68 MVnDfZRwfG:6aXOgRZN{[Xl? M3jUe|ExKM7:TR?= NEi4cYI4OiCq MkjPSG1UVw>? NHzNbYRKSzVyPUSuOkDPxE1? NYHrTW9NOjN3N{C1OFI>
MEF NYG4elFES3m2b4TvfIlkKEG|c3H5 M3XuXFExKM7:TR?= NU[2eY1PPzJiaB?= M2T4SmROW09? NWL3TZZDUUN3ME20MlQh|ryP NWfVboNlOjN3N{C1OFI>
BGC823 NFL1VmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHEUXNQ NE\IbXFIUTVyPUOuNFkh|ryP MX2yN|YxOTdyNh?=
High5 MW\LbY5ie2ViQYPzZZk> NXzXWHFSOjRiaB?= NYrsSIVwUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDISGFEPiC5aYToJGlEPTBib3[gNE4xQSEQvF2= NIjITVczOzZyMkWyNy=>
High5 MmjMT4lv[XOnIFHzd4F6 MYeyOEBp M2D3VGlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiSFTBR|Ehf2m2aDDJR|UxKG:oIECuNVIh|ryP NX3NepJHOjN4MEK1NlM>
High5 MX\LbY5ie2ViQYPzZZk> M4D6PVI1KGh? MknPTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCKRFHDN{B4cXSqIFnDOVAhd2ZiMD6xO{DPxE1? MmTVNlM3ODJ3MkO=
A549 NFHGVIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVi1[VhqTE2VTx?= NXH1XFNCUUN3ME2xMlA4QSEQvF2= MVOyN|Y1PDJzMB?=
HCT116 MlLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zCcmROW09? M33sWGlEPTB;MD63OVch|ryP MmD0NlM3PDR{MUC=
K562 MmjnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvYSG1UVw>? NHzBNnVKSzVyPUCuOlQ2KM7:TR?= NEnNbo0zOzZ2NEKxNC=>
GBC-SD NVTYT49DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVy1JO69VQ>? M37P[FczKGh? NVntfVBqTE2VTx?= NGHtb4tKSzVyPUG0Mlgh|ryP NULB[IZQOjN5MEeyOlA>
HGC27 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGG5fWc2KM7:TR?= M2m4c|czKGh? MVzEUXNQ MXvJR|UxRTVwNDFOwG0> NYfwNWl5OjN5MEeyOlA>
HL60 MWTLbY5ie2ViQYPzZZk> NUDUTYNRPSEQvF2= MkHqNlQhcA>? M1n1UmROW09? NUfLbohHUW6qaXLpeIlwdiCxZjDISGFE NIrHU4IzOzdyN{K2NC=>
Vero NEjSOYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vY[VczKGh? MWLEUXNQ M1S0R2lEPTB;MD65JO69VQ>? NVLaVFBQOjN5OE[0OVI>
NCI60 NUfyTJlCS3m2b4TvfIlkKEG|c3H5 MXK0PEBp MWjEUXNQ MYPHTV0xNjV|IN88US=> NGf4epczPDBzNUOyOy=>
SW620 M3f4[GN6fG:2b4jpZ{BCe3OjeR?= NVPjOGxGPDhiaB?= NGPlT4ZFVVOR NFW4NHZIUT1yLkW0JO69VQ>? MlX6NlQxOTV|Mke=
U251 NVO0cop2S3m2b4TvfIlkKEG|c3H5 M1zZVVQ5KGh? NFr6fXNFVVOR NUHTT29zT0l;MT61N{DPxE1? Mm\QNlQxOTV|Mke=
KM12 M3H5c2N6fG:2b4jpZ{BCe3OjeR?= MkDmOFghcA>? Mm\VSG1UVw>? Ml;FS2k:OS56ODFOwG0> M4LCeFI1ODF3M{K3
Hs578T NYfWTot1S3m2b4TvfIlkKEG|c3H5 MnfUOFghcA>? NHjNU5RFVVOR NEPPcY1IUT12LkizJO69VQ>? NX\Qc2VqOjRyMUWzNlc>
MDA-MB-231 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nCeFQ5KGh? MnvJTWM2OD1yLkG2JO69VQ>? Mm\wNlQxQTVyMU[=
MCF7 MlzQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFv1T3k1QCCq MoOyS2k:OC52NTFOwG0> M2PWR|I1OTF7NUW1
MDA-MB-435 MnHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;3dHE1QCCq MnnHS2k:OC56ODFOwG0> NV7EZ4o{OjRzMUm1OVU>
AsPC1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVWzNEDPxE1? M1LxVVQ5KGh? MlexSG1UVw>? NVz4XFNmUUN3ME2zMlY3KM7:TR?= MnnGNlQyQDV|N{i=
Jurkat E6.1 NH\WfmlMcW6jc3WgRZN{[Xl? NVjWUnJmOiCq Ml;wSG1UVw>? NEHx[GVKdmirYnn0bY9vKG:oIFjERWM1KHerdHigTWM2OCCxZjCwMlA1KM7:TR?= NH:1V|IzPDJ4MUi2Ni=>
KG1 MkjlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYe4c414PDhiaB?= NYn0ZoVTUUN3ME2xMlE2KM7:TR?= MVqyOFUzPTByMx?=
HEL M13FRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jQN|Q5KGh? MVPEUXNQ M2LhUmlEPTB;MD60PUDPxE1? MVKyOFY6PDB3NR?=
HSC3 M3XKZmN6fG:2b4jpZ{BCe3OjeR?= M4rXN|EzKGh? MkDsSG1UVw>? MXPJR|UxRTBwN{Gg{txO MWSyOFc3PjV4MB?=
HT-29 MYrDfZRwfG:6aXOgRZN{[Xl? MX6xNkBp M4\xO2ROW09? MnvJTWM2OD1yLkeyJO69VQ>? MUiyOFc3PjV4MB?=
KB MXvDfZRwfG:6aXOgRZN{[Xl? NYLHSlNkOTJiaB?= NVXmRnYzTE2VTx?= NVTyd3VCUUN3ME2wMlc2KM7:TR?= NVrVdWR1OjR5Nk[1OlA>
H460 MUfDfZRwfG:6aXOgRZN{[Xl? M3:w[FEzKGh? NInWPW9FVVOR NHW5cWhKSzVyPUCuPFIh|ryP NUfKcVBbOjR5Nk[1OlA>
MONE1 MX7DfZRwfG:6aXOgRZN{[Xl? MV2xNkBp M1fqTGROW09? MnryTWM2OD1zLkG4JO69VQ>? MnTZNlQ4PjZ3NkC=
MKN45 M{Xj[2N6fG:2b4jpZ{BCe3OjeR?= NVfaO4tDOTJiaB?= M3XMWGROW09? M3jkbGlEPTB;MT6yOUDPxE1? MXqyOFc3PjV4MB?=
TSGH NULNS4NkS3m2b4TvfIlkKEG|c3H5 MWexNkBp NHTINIFFVVOR MX\JR|UxRTJwMEmg{txO NFLvZ28zPDd4NkW2NC=>
HL60 NGjXTG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HLR|czKGh? NITDZoFFVVOR MoTLS2k2OD1yLkmzJO69VQ>? M1zWTFI1QTByNUCw
HEK293 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\UPVQ4OiCq Mn7OSG1UVw>? NGnl[2hIUTVyPUGzJO69VQ>? M3HzUVI1QTByNUCw
Jurkat MYTDfZRwfG:6aXOgRZN{[Xl? NGTFNo4yODBizszN M3y2NVczKGh? NWXRepljT0l3ME2wMlkh|ryP NYniS2dYOjR7MEC3OFM>
GM15850 MVjLbY5ie2ViQYPzZZk> MYGyMlUh|ryP MYi5OkBp NW\QdW5qTE2VTx?= M1LFcIRw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg{KGy7c3nu[UAyPCCjY3X0fYxifGmxbjDv[kBHYE5iZ3Xu[S=> MlG1NVY6OjF|Nke=
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GM15850 M{LjNGtqdmG|ZTDBd5NigQ>? NY\MVXJUOi53IN88US=> Mo\wPVYhcA>? NVnMeJlPTE2VTx?= NITtVYNld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJPCCueYPpcoUhOTJiYXPleJlt[XSrb36gc4YhTliQIHflcoU> M4C4TFE3QTJzM{[3
GM15850 NXrx[XptU2mwYYPlJGF{e2G7 NYL2SXluOi53IN88US=> NFzw[Jg6PiCq MX7EUXNQ M4Hqe4Rw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg{KGy7c3nu[UA6KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l MmezNVY6OjF|Nke=
GM15850 NYDGNWlLU2mwYYPlJGF{e2G7 NGT3PIwzNjVizszN NYTNXZg5QTZiaB?= Ml:0SG1UVw>? MWTkc4V{KG6xdDDpcohq[mm2IFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgPEBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= MUOxOlkzOTN4Nx?=
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Jurkat Mmj3R5l1d3SxeHnjJGF{e2G7 MViyNEDPxE1? NH3X[ZU4OiCq M2WxPGROW09? NUPtSFhudm9iY4n0c5RwgGmlaYT5JIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9v NVPVO|lxOjR|MESzOFg>
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BHT-101 NHzNeHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIKzc4VKSzVyPUK0OE4yQCCwTR?= MUDTRW5ITVJ?
H9 NFLT[5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmntTWM2OD1{NUWuNFQhdk1? NFP0e|BUSU6JRWK=
PA-1 NGHiR5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3O2TmlEPTB;Mki2MlI3KG6P MWHTRW5ITVJ?
NEC8 M3z1OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\qTWlEPTB;Mki5MlM5KG6P NYDWNIxUW0GQR1XS
MHH-PREB-1 MnzkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTJ7ND61N{BvVQ>? M1PvfnNCVkeHUh?=
NB7 NHLzbVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXCeo17UUN3ME2zOFUvPzRibl2= MnjzV2FPT0WU
A3-KAW MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTRyMD61PUBvVQ>? MoPwV2FPT0WU
NB69 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jEdWlEPTB;NEGxMlcyKG6P NYLqTGZGW0GQR1XS
EoL-1-cell NV;JVJp2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTR3NEK1JI5O MofBV2FPT0WU
CHP-212 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\GSHNKSzVyPUS1O{42OyCwTR?= NX22[4Z2W0GQR1XS
C2BBe1 NYjuXHVrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnSSXlKSzVyPUS3Nk4yQSCwTR?= NGnYRo9USU6JRWK=
697 NVHITWV6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlW3TWM2OD12N{OuOFEhdk1? NF3WZZNUSU6JRWK=
BCPAP NXjtWm96T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfzOI1kUUN3ME21NFEvPDJibl2= NET3WY9USU6JRWK=
L-363 NXTYe2txT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13RR2lEPTB;NUCzMlEhdk1? M1O2OHNCVkeHUh?=
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BE-13 NV25U5hbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHOzepRKSzVyPUWyOk46PiCwTR?= NUPxNmcxW0GQR1XS
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HD-MY-Z Mn;3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHH6[XdKSzVyPUWzPE4yOyCwTR?= M1vBSHNCVkeHUh?=
NKM-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTV2ND6yO{BvVQ>? Ml;VV2FPT0WU
NCI-H720 NH7KenZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\qWnhKSzVyPUW2NE4yQCCwTR?= MoLRV2FPT0WU
KY821 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;LWlZMUUN3ME21OlMvOjVibl2= MWPTRW5ITVJ?
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CTV-1 NWXBOlhVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUftcWMxUUN3ME21PFEvPTZibl2= NUfITJltW0GQR1XS
P12-ICHIKAWA MlLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTV7Nj61NUBvVQ>? MU\TRW5ITVJ?
DB NFThenRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTV7OD61O{BvVQ>? MljpV2FPT0WU
CHL-1 MnjjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{j0W2lEPTB;NkSyMlA5KG6P M4DaSnNCVkeHUh?=
A4-Fuk NU[3XWVYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTZ2ND65NUBvVQ>? MmP5V2FPT0WU
MV-4-11 M1\N[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\nTWM2OD14NUmuNUBvVQ>? NVW4dnJoW0GQR1XS
RPMI-8226 MmrZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTLNWVKSzVyPU[3PE4yQCCwTR?= M2nrVnNCVkeHUh?=
NB14 NY[2S2h3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmC1TWM2OD14OU[uPVUhdk1? NYT3N3NJW0GQR1XS
DOHH-2 MmnQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX63WG86UUN3ME23NFYvPjhibl2= MYrTRW5ITVJ?
D-423MG MkTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXITWM2OD15ME[uPFkhdk1? NYfVOmVlW0GQR1XS
D-283MED NWDLTYRlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWe5XFVbUUN3ME23NVQvOTRibl2= MmjiV2FPT0WU
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GOTO M3PHZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rh[GlEPTB;N{K5MlEzKG6P NWPKSmp6W0GQR1XS
NCI-H209 NWm4RYp[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\WfWJKSzVyPUeyPU46KG6P M1\MZ3NCVkeHUh?=
MOLT-13 NITkbZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3X3UGlEPTB;N{O4Mlk5KG6P MWXTRW5ITVJ?
ATN-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjNTWM2OD15NECuNlghdk1? MVfTRW5ITVJ?
DU-4475 NXTubZhET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvEW|RxUUN3ME23OVEvQTFibl2= NUDMXWtVW0GQR1XS
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KG-1 NX70XGtOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHuTWM2OD15N{WuOFUhdk1? M3LTOXNCVkeHUh?=
MOLT-4 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmmzTWM2OD15OEeuOFYhdk1? MVLTRW5ITVJ?
TE-1 NIniUpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rxRWlEPTB;N{mxMlEhdk1? NHHjZVRUSU6JRWK=
SBC-1 NITi[o1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\hTGZKSzVyPUe5N{45PCCwTR?= NGnTd4ZUSU6JRWK=
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KU812 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TCOGlEPTB;OEGzMlEhdk1? M3\vUnNCVkeHUh?=
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ALL-PO NFjTUIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRThzND62OkBvVQ>? M3vYS3NCVkeHUh?=
LU-139 NIHrTJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\ZNo5KSzVyPUiyNk45PiCwTR?= MWHTRW5ITVJ?
RS4-11 M3LCdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojMTWM2OD16M{KuOFUhdk1? M4Tpd3NCVkeHUh?=
EW-18 Mnz3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnveFJKSzVyPUizNk46PiCwTR?= MlfoV2FPT0WU
P30-OHK Mo\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPDbnA{UUN3ME24N|UvPyCwTR?= NXmzPXJvW0GQR1XS
D-566MG M2rBWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTkTWM2OD16M{iuOlIhdk1? MlXPV2FPT0WU
HSC-4 NWLiWWE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4ryfmlEPTB;OES2MlUyKG6P NWLnNY5FW0GQR1XS
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HGC-27 M1PPdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2niUmlEPTB;OEeyMlM1KG6P M1LCUHNCVkeHUh?=
HH MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7keZZKSzVyPUi5OE4yOiCwTR?= NYTXTIZjW0GQR1XS
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A427 M37kO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3j2XWlEPTB;OUKwMlg1KG6P NWHTUZZkW0GQR1XS
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HAL-01 NXfTdFFKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17T[mlEPTB;OU[4MlA1KG6P NWnSNmVLW0GQR1XS
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MEL-HO MkXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nuOGlEPTB;MT6wNFU5OiEQvF2= MXvTRW5ITVJ?
MS-1 NGPZ[5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjpVGNwUUN3ME2xMlAxPjF5IN88US=> NIG5c|RUSU6JRWK=
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MN-60 MmXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\JNWlEPTB;MT6wNlY5KM7:TR?= NUTXcogyW0GQR1XS
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EFM-19 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTFwMES4O|kh|ryP M4rOSnNCVkeHUh?=
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LB831-BLC MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWn0eIYxUUN3ME25MlQ2OTdzIN88US=> NELLWoxUSU6JRWK=
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SH-4 Mn3OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\YemlKUUN3ME25MlQ6OzZ2IN88US=> NYLaemw4W0GQR1XS
IST-MES1 NF61[m5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTlwNUG2OFQh|ryP MmrmV2FPT0WU
Saos-2 NWj5WWhGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\xTmtzUUN3ME25MlUzOTl3IN88US=> MYnTRW5ITVJ?
NCI-H2087 NGrkNVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PX[mlEPTB;OT62O|M2OiEQvF2= MmW2V2FPT0WU
SCC-9 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\XTWM2OD17LkexPFE3KM7:TR?= MVfTRW5ITVJ?
MFE-280 M3\uRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTlwN{K3PFUh|ryP NXzWUpExW0GQR1XS
BEN NVjmTmJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTlwOEKxOVkh|ryP NI\kbWhUSU6JRWK=
CP50-MEL-B MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHnTWM2OD17LkmyOFMzKM7:TR?= NFfiPHRUSU6JRWK=
SK-MEL-28 NWLNdXpPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTkTWM2OD1zMD6wNVk{KM7:TR?= MWXTRW5ITVJ?
NCI-H2452 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LlR2lEPTB;MUCuNVYh|ryP NV\mXIhzW0GQR1XS
NCI-H1395 Ml;RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfFV4FKSzVyPUGwMlE4QCEQvF2= M3vjc3NCVkeHUh?=
NCI-H2052 MmjmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XPWWlEPTB;MUCuNVg5OiEQvF2= MoHIV2FPT0WU
A375 NGPLSGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnGTWM2OD1zMD6yOFUzKM7:TR?= M2DGXnNCVkeHUh?=
HCC38 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NES2[45KSzVyPUGwMlMzOiEQvF2= NHPUSZZUSU6JRWK=
LK-2 NHe5N4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLMTWM2OD1zMD60NlA5KM7:TR?= MU\TRW5ITVJ?
SF126 NISwd2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnLTWM2OD1zMD60O|I4KM7:TR?= NG\DdYdUSU6JRWK=
SK-MEL-1 NHn5WXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTFyLke4N|gh|ryP Mm\nV2FPT0WU
ACN MnHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULVZmZSUUN3ME2xNE45Pjd7IN88US=> MmrFV2FPT0WU
BB30-HNC M4f3OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XMdWlEPTB;MUCuPFcyOSEQvF2= MmXtV2FPT0WU
NCI-H747 NFO5fHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUKzWGxGUUN3ME2xNE45PzR4IN88US=> MVrTRW5ITVJ?
KYSE-150 M1;IdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE[0fmRKSzVyPUGxMlA{QDdizszN NW\MbpU5W0GQR1XS
D-247MG MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LPUGlEPTB;MUGuNVAxQSEQvF2= NHu3NGVUSU6JRWK=
BxPC-3 MlfpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nLVWlEPTB;MUGuN|c1PyEQvF2= MYDTRW5ITVJ?
SK-MEL-30 M1r1VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTFzLkSwO|kh|ryP NWqxNWR7W0GQR1XS
CAS-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTFzLkSxNFkh|ryP NFnIW2hUSU6JRWK=
no-10 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTF{LkGyNVch|ryP NXX1Nm9PW0GQR1XS
NCI-H2405 M2XieWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mly3TWM2OD1zMj6yNFM3KM7:TR?= NHj2RpFUSU6JRWK=
KGN NHnlSJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEGzWJpKSzVyPUGyMlI6ODFizszN MnPsV2FPT0WU
BB49-HNC NF3sblFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXQTWM2OD1zMj6zPVU3KM7:TR?= NUPuVI1DW0GQR1XS
NCI-H1693 MlzvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLLNY9KSzVyPUGyMlU5OTZizszN NX3BfFlUW0GQR1XS
RO82-W-1 M4KwPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTF|LkC2OFkh|ryP MofZV2FPT0WU
CAL-85-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\5dVBmUUN3ME2xN{41Ozl7IN88US=> NEHmbmFUSU6JRWK=
H-EMC-SS NUTTOXBZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHKPVFKSzVyPUGzMlkyODRizszN NEOwN21USU6JRWK=
SW1783 MoXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzRTWM2OD1zND6yN|kyKM7:TR?= NGLYbmdUSU6JRWK=
LB771-HNC MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzsdopnUUN3ME2xOE41OTlizszN M4DtO3NCVkeHUh?=
HCC70 MnvSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXjNo9oUUN3ME2xOE41OjN|IN88US=> NHy1N41USU6JRWK=
KNS-81-FD M{j3TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmj4TWM2OD1zND63NFQ2KM7:TR?= M{GyVnNCVkeHUh?=
KYSE-520 NVfDcpBpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfBeIN4UUN3ME2xOE46OjdizszN MUDTRW5ITVJ?
TGBC24TKB M1jXdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVT4PXk{UUN3ME2xOE46PTN7IN88US=> NYTQR2hjW0GQR1XS
SNB75 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETyUohKSzVyPUG1MlA4OjlizszN MkS2V2FPT0WU
SW872 M{S1[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoX4TWM2OD1zNT6yNlE5KM7:TR?= M1jvd3NCVkeHUh?=
U031 NVTuUpJCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjF[Y9KSzVyPUG1MlgxOjhizszN M3vpWHNCVkeHUh?=
ChaGo-K-1 M3\z[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfJTWM2OD1zNT64N|U6KM7:TR?= NYPYTG9vW0GQR1XS
NCI-H441 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvTTWM2OD1zNj6wNFM6KM7:TR?= MnLCV2FPT0WU
TE-12 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTF4LkG4O|Mh|ryP MorMV2FPT0WU
NCI-H1755 MkfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTF4LkW3N{DPxE1? NYHlfZFjW0GQR1XS
KNS-42 NXrTV4J5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzlTWM2OD1zNj62OVg6KM7:TR?= M2GxdXNCVkeHUh?=
SK-PN-DW MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIi1UZRKSzVyPUG3MlQzODFizszN MXXTRW5ITVJ?
NCI-H226 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILXbotKSzVyPUG3Mlk{PDVizszN MoDEV2FPT0WU
K-562 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHETWM2OD1zOD62N|E4KM7:TR?= Mn;2V2FPT0WU
A388 MnLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjPelhkUUN3ME2xPU4xOzB|IN88US=> MYTTRW5ITVJ?
ZR-75-30 NIDHVopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTF7LkC5Olgh|ryP M1HOc3NCVkeHUh?=
LU-135 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTJdFJ7UUN3ME2xPU4zPjN4IN88US=> NHTRSpBUSU6JRWK=
NCI-H2029 NVOwcHVXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTF7Lk[wNlEh|ryP M1fEXnNCVkeHUh?=
HT-1197 NVTPSol4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGG2fI1KSzVyPUG5MlkzOjdizszN MVnTRW5ITVJ?
IGR-1 NXzFS|g2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rJTmlEPTB;MkCuN|EyPyEQvF2= MV7TRW5ITVJ?
U-87-MG NEPueZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjsPJRKSzVyPUKwMlY1OTNizszN NGjBTI5USU6JRWK=
NCI-H1304 Mnn2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrQbnNKSzVyPUKwMlc2ODFizszN MVTTRW5ITVJ?
RCC10RGB MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkGyTWM2OD1{MT6yPFI6KM7:TR?= NUP5O5U5W0GQR1XS
NCI-H520 Mo\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXzbZJMUUN3ME2yNk44PjFzIN88US=> NUX2PZh3W0GQR1XS
SK-LU-1 NITWTYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zuOGlEPTB;MkOuNFcyQCEQvF2= Mmm0V2FPT0WU
UACC-893 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTJ|LkGwN|gh|ryP NH\lO5ZUSU6JRWK=
NCI-H2347 NV[z[YYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTJ|LkK2O|Qh|ryP NVHX[VdHW0GQR1XS
U-118-MG MmTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTJ|LkeyNVch|ryP M{nScXNCVkeHUh?=
NCI-H596 NYTwbnJRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\zTWM2OD1{Mz65NFU2KM7:TR?= M1vQV3NCVkeHUh?=
MZ1-PC Mn\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDtXFNKSzVyPUK0MlY4PTlizszN NXfRNY1LW0GQR1XS
SW1417 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NECxW49KSzVyPUK1MlI1QThizszN MXvTRW5ITVJ?
NCI-H82 NIDYe4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7wZlRKSzVyPUK2MlQzQDhizszN M3v6SHNCVkeHUh?=
COLO-678 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfBTWM2OD1{Nz60PVE6KM7:TR?= MYXTRW5ITVJ?
KURAMOCHI NVvCfVFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4r6Z2lEPTB;MkiuNVI3KM7:TR?= MX;TRW5ITVJ?
NCI-H1650 MorSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTNyLkG5NlQh|ryP MlT6V2FPT0WU
HCC1954 NXy2S4RvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\iRmdEUUN3ME2zNU4{PjZ4IN88US=> MV;TRW5ITVJ?
GAK MoK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DvXWlEPTB;M{KuNlYyPiEQvF2= NXqwSpZEW0GQR1XS
YAPC M4LySmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjqUI5KSzVyPUOzMlc3PDhizszN M{HKNXNCVkeHUh?=
NCI-H2228 NEXoZW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PJPWlEPTB;M{SuN|YxPSEQvF2= MoH5V2FPT0WU
VMRC-RCZ MkLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3ezT2lEPTB;M{[uN|AzOiEQvF2= NHj5VZlUSU6JRWK=
NMC-G1 M3TzcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVX3VpV2UUN3ME2zO{4xPTJ7IN88US=> Mm\SV2FPT0WU
D-336MG M{DyUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;JRnBKSzVyPUSxMlg1PDJizszN M{LPO3NCVkeHUh?=
UACC-62 NHTYNm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PrPGlEPTB;NEKuOVUxPSEQvF2= M{G3RnNCVkeHUh?=
C-33-A NHXI[ZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzzTWM2OD12NT6zNlU3KM7:TR?= M2W1R3NCVkeHUh?=
HCC1937 M3TFcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLWd5NiUUN3ME20O{4yQTV6IN88US=> NXPNRXlEW0GQR1XS
HDLM-2 NGK0W2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDvOJpuUUN3ME20O{4zOjh5IN88US=> MlPSV2FPT0WU
NCI-H727 NV\ESW1bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnUTWM2OD12Nz6yOFUyKM7:TR?= MVPTRW5ITVJ?
NY MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTR7LkO5NFgh|ryP NWK4WolsW0GQR1XS
NCI-H2291 NUXDNmoyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTR7LkizNFEh|ryP NWroV3k1W0GQR1XS

... Click to View More Cell Line Experimental Data
体内研究 Decitabine和Vorinostat都具有使肿瘤衰退的功能。然而, Decitabine 和 Vorinostat 联用使肿瘤衰退的效果更强。没有任何处理时,在野生型和Fasgld 小鼠中在肺肿瘤负担方面观察不到明显的区别。然而, Decitabine 和Vorinostat联用处理野生型小鼠，使肿瘤衰退比处理 Fasgld小鼠效果高很多。 Decitabine和Vorinostat使结肠癌细胞对FasL调节的肿瘤衰退敏感。低剂量Decitabine和Vorinostat处理，没有明显的肝脏毒性。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验：[4]
+ 展开

组蛋白去乙酰化酶活性测定:

为了进行 HDAC 实验24 × 104 dpm 乙醇溶液(1 mCi/ml)中提供的sup>3H-醋酸钠盐标记的组蛋白H4等份样, 加到每个试管中，试管中含悬浮在25 µL实验buffer(100 mM Tris-HCl pH 8, 2mM EDTA)中的200 µg全部HeLa细胞裂解液进行免疫沉淀获得的HDAC。加入不同浓度Vorinostat，在30oC下温育90分钟。加入20 µL 终止缓冲液(0.5 N HCl, 0.08 M AcOH)终止反应。加入0.8 mL TBME提取释放放入氚醋酸盐。在8,000 × g 转速下离心5分钟，600 µL 有机相(上相) 转移到包含3 mL闪烁液的闪烁瓶中。
细胞实验：[4]
+ 展开
  • Cell lines: NB4, NCI-H460和HCT-116肿瘤细胞系
  • Concentrations: 0 μM - 0.1 μM
  • Incubation Time: 48小时
  • Method: NB4, NCI-H460和HCT-116肿瘤细胞系生长在200 µL 96孔板中，约10%汇合，生长24小时后，覆盖孔中。使用多种浓度 Vorinostat或溶剂处理肿瘤细胞24小时。处理后，冲洗实验板，移除Vorinostat，温育48小时。使用sulphorodamine B 实验测定Vorinostat处理后存活细胞的分数。
    (Only for Reference)
动物实验：[3]
+ 展开
  • Animal Models: 携带CT26 细胞的Fasgld BALB/cByJ小鼠
  • Formulation: Dissolved in DMSO
  • Dosages: 25 mg/kg
  • Administration: 静脉注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 52 mg/mL (196.74 mM)
Ethanol 3 mg/mL (11.35 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)：
2% DMSO+30% PEG 300+5% Tween 80+ddH2O 		5mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 264.3
化学式

C14H20N2O3
CAS号 149647-78-9
稳定性 powder
in solvent
别名 SAHA, MK0683, suberoylanilide hydroxamic acid

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量：

总分子量：g/mol

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03022565 Recruiting Uveal Melanoma University of Miami|University of Miami Sylvester Comprehensive Cancer Center July 2019 Early Phase 1
NCT03022565 Recruiting Uveal Melanoma University of Miami|University of Miami Sylvester Comprehensive Cancer Center July 2019 Early Phase 1
NCT03843528 Not yet recruiting Acute Myeloid Leukemia|Myelodysplastic Syndromes|Mixed Phenotype Acute Leukemia|Juvenile Myelomonocytic Leukemia Johns Hopkins All Children''s Hospital May 1 2019 Phase 1
NCT03843528 Not yet recruiting Acute Myeloid Leukemia|Myelodysplastic Syndromes|Mixed Phenotype Acute Leukemia|Juvenile Myelomonocytic Leukemia Johns Hopkins All Children''s Hospital May 1 2019 Phase 1
NCT03742245 Not yet recruiting Breast Cancer Metastatic|Breast Cancer Jenny C. Chang MD|AstraZeneca|The Methodist Hospital System April 1 2019 Phase 1
NCT03742245 Not yet recruiting Breast Cancer Metastatic|Breast Cancer Jenny C. Chang MD|AstraZeneca|The Methodist Hospital System April 1 2019 Phase 1

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1：

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • 回答：

    We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

Selleck产品目录册

HDAC Signaling Pathway Map

HDAC Inhibitors with Unique Features

相关HDAC产品

  • LMK-235 New

    LMK-235是HDAC4和HDAC5的选择性抑制剂， IC50分别为11.9 nM 和 4.2 nM。

  • CAY10603 New

    CAY10603是一种强效的选择性HDAC6抑制剂，IC50为2 pM，选择性比其它HDACs高200多倍。

  • Domatinostat (4SC-202) New

    4SC-202是一种选择性的I类HDAC抑制剂，对HDAC1，HDAC2，和HDAC3的IC50分别为1.20 μM，1.12 μM，和0.57 μM。也对Lysine specific demethylase 1 (LSD1)表现出抑制活性。Phase 1。

  • Panobinostat (LBH589)

    Panobinostat (LBH589)是一种新型的，广谱HDAC抑制剂，无细胞试验中IC50为5 nM。Phase 3。

  • Entinostat (MS-275)

    Entinostat (MS-275)强烈抑制HDAC1和HDAC3，无细胞试验中IC50分别为0.51 μM和1.7 μM，抑制作用强于HDACs 4， 6， 8，和10。Phase 3。

  • Trichostatin A (TSA)

    Trichostatin A (TSA)是一种HDAC抑制剂，无细胞试验中IC50为1.8 nM左右。

  • Romidepsin (FK228, Depsipeptide)

    Romidepsin (FK228, Depsipeptide)是一种有效的HDAC1和HDAC2抑制剂，无细胞试验中IC50分别为36 nM和47 nM。

    Features:Romidepsin对I型HDAC的抑制作用明显强于对II型HDAC的抑制。

  • RGFP966

    RGFP966是一种HDAC3抑制剂，无细胞试验中IC50为0.08μM ，比作用于其他HDAC选择性高200倍以上。

  • Tubastatin A

    Tubastatin A是一种有效的，选择性HDAC6抑制剂，无细胞试验中IC50为15 nM，选择性远高于所有其他同工酶(1000倍)除了HDAC8(57倍)。

  • Mocetinostat (MGCD0103)

    Mocetinostat (MGCD0103)是一种有效的HDAC抑制剂，对HDAC1抑制作用最强，无细胞试验中IC50为0.15 μM，比作用于HDAC2， 3，和11选择性高2到10倍，对HDAC4， 5， 6， 7，和8没有抑制活性。Phase 2。

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