Vorinostat (SAHA)

For research use only. Not for use in humans.

目录号:S1047 别名: MK0683, Suberoylanilide hydroxamic acid, Zolinza 中文名称:伏立诺他

Vorinostat (SAHA) Chemical Structure

CAS No. 149647-78-9

Vorinostat (suberoylanilide hydroxamic acid, SAHA, MK0683, Zolinza)是一种HDAC抑制剂,无细胞试验中IC50为~10 nM。Vorinostat 会抑制高效的HPV-18 DNA扩增。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1558.77 现货
RMB 1198.15 现货
RMB 1794.86 现货
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客户使用Selleck生产的Vorinostat (SAHA)发表文献467篇:

产品安全说明书

HDAC抑制剂选择性比较

生物活性

产品描述 Vorinostat (suberoylanilide hydroxamic acid, SAHA, MK0683, Zolinza)是一种HDAC抑制剂,无细胞试验中IC50为~10 nM。Vorinostat 会抑制高效的HPV-18 DNA扩增。
特性 Vorinostat是广谱HDAC活性抑制剂,抑制I和II类酶 。
靶点
HDAC [1]
(Cell-free assay)
~10 nM
体外研究

Vorinostat是小分子量(<300)线性肟酸,抑制HDAC活性,包括乙酰化组蛋白和非组蛋白的积累,抑制培养细胞的增殖,且抑制肿瘤生长。Vorinostat通过结合到酶的活性位点而抑制 HDAC活性。Vorinostat 抑制多种转化细胞增殖(包括 淋巴瘤,多发性骨髓瘤,白血病,和非小细胞肺癌),与对照组相比抑制生长达50% 时的浓度为0.5 到10μM。Vorinostat作用于淋巴瘤和白血病细胞,包括 Burkitt, B-细胞急性淋巴细胞白血病 (B-ALL), MCL, DLBCL, ATL和T-细胞,不同程度抑制细胞增殖。除了抑制转化细胞增殖, Vorinostat 也抑制正常细胞增殖,通过比较Vorinostat 作用于一组细胞系–正常人非纤维细胞(WI-38)和 SV40巨大T抗原转化WI-38(VA-13细胞)而得到证明。Vorinostat 抑制两种类型细胞增殖,这种作用存在剂量依赖性。但发现Vorinostat 对转化细胞具有选择毒性,包括使肿瘤细胞死亡,而对正常细胞只起抑制作用,不会使其死亡。[1] Genistein 和Vorinostat 联用效果比5-aza和Vorinostat 联用作用于诱导细胞死亡有效很多。Genistein和Vorinostat联用作用于ARCaP-E使增殖降低 80 %,作用于ARCaP-M细胞,增殖降低60 %以上。Genistein和Vorinostat 联用抑制细胞增殖具有协同效应。作用于ARCaP-E 细胞(820个基因 诱导和1046个基因抑制) ARCaP-M 细胞,Vorinostat比Genistein 影响更多基因。[2] Vorinostat作用于肿瘤细胞表面,提高Fas蛋白水平,这种作用存在剂量依赖性,且按0.75 μM剂量处理,提高达到一个稳定水平。[3] Vorinostat 抑制肿瘤细胞生长,包括NB4, H460 和HCT-116,IC50分别为0.7μM, 3.4μM和1.2 μM。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
H1299 NFjlUmpMcW6jc3WgRZN{[Xl? M1XQVFIxKG2rbh?= MXXEUXNQ NED1Z4VKdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QhUESDQzDlcpp6dWVid3n0bEBKSzVyIH;mJFAvOTl2IN88US=> M2TBeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF2NUKxOFIzLz5zNEWyNVQzOjxxYU6=
HT1080 NHTKU|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH20Uok4OiCq NXj4fYFFTE2VTx?= NX30[WFZUUN3ME2yMlQh|ryP MmPlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ{N{CxO|UoRjF{MkewNVc2RC:jPh?=
K562 NGK1NlNMcW6jc3WgRZN{[Xl? NFXB[VM3KGh? M2qwd2ROW09? M37HXmlvcGmkaYTpc44hd2ZiaIXtZY4hcGm|dH;u[UBl\WGlZYT5cIF{\SBqbXn4eJVz\SCxZjDISGFEOSCjbnSgTGRCSzJrIIfpeIghUUN3MDDv[kAxNjBzIN88US=> NETP[FE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkSxPVM5OCd-MUK0NVk{QDB:L3G+
A20 NXHZZnllU2mwYYPlJGF{e2G7 NH30dmgyKGh? NYO4eWc4TE2VTx?= Mm[1ZY51cS2KRFHDNUBi[3Srdnn0fUB4cXSqIFnDOVAhd2ZiMD6xNVIh|ryP NFi3fo09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUm2NFQ5QSd-MUG5OlA1QDl:L3G+
Friend leukemic cell MmTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYCxUHhmPTBizszN M4nRfVczKGh? NX3tSIFTTE2VTx?= MlHvTWM2OD1yLkm5JO69VQ>? NFzNeIc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkGwPVkyOyd-MUKxNFk6OTN:L3G+
H1299 M{G0fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHv6WWk4OiCq MUfEUXNQ NYjzdopzUUN3ME23MlI1KM7:TR?= M2TxT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF2NUKxOFIzLz5zNEWyNVQzOjxxYU6=
HeLa MY\LbY5ie2ViQYPzZZk> NWfTUmZNOzBibXnu NEDjXFdKdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gZYdicW6|dDDobZN1d26nIHTlZYNmfHmuYYPlJJdqfGhiSVO1NEBw\iByLkK4JO69VQ>? MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTZyM{m0PUc,OTV4MEO5OFk9N2F-
LOX-IMVI MkDuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPwOFghcA>? MoPITWM2OD1zLkOg{txO NXK2enJLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW3NVU1PzBpPkG1O|E2PDdyPD;hQi=>
NCI-H226 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHSzUlA1QCCq NEjxSWJKSzVyPUKuOkDPxE1? M1fRSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3N{G1OFcxLz5zNUexOVQ4ODxxYU6=
RXF-631L MmTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PXeFQ5KGh? Moj0TWM2OD1{IN88US=> NVzPOo5iRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW3NVU1PzBpPkG1O|E2PDdyPD;hQi=>
SNB-78 NWLKNY5DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DJNFQ5KGh? NYHzPIZ{UUN3ME2xOkDPxE1? MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTdzNUS3NEc,OTV5MUW0O|A9N2F-
St-4 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXmz[mxZPDhiaB?= MU\JR|UxRTVwMjFOwG0> NX3OXFQ4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW3NVU1PzBpPkG1O|E2PDdyPD;hQi=>
ARP1 M3vtU2Z2dmO2aX;uJGF{e2G7 NWLCeYh2OiEQvF2= NWnsOHBVPiCq MX\JcoR2[3Srb36gc4YhWDJzV1HGNUBo\W6nIHX4dJJme3Orb36= M4LGW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF2N{O0PFA3Lz5zNEezOFgxPjxxYU6=
CEM M1S5VGtqdmG|ZTDBd5NigQ>? M{HWOVEhcA>? NV;vTVRPTE2VTx?= NX3pNm1bUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlM{KM7:TR?= NXTlfYxzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[0NlAxPjRpPkG2OFIxODZ2PD;hQi=>
HCT15 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHOWVk1QCCq NF:xW|RIUTVyPUCuPFIh|ryP MmO5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ5MkOyNlcoRjF4N{KzNlI4RC:jPh?=
NCI-H23 MoW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUW0PEBp MknZS2k2OD1yLkmyJO69VQ>? NGTwd2o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkeyN|IzPyd-MU[3NlMzOjd:L3G+
GM15850 NF\WTmRMcW6jc3WgRZN{[Xl? NGfYZ3AzNjVizszN MmTDPVYhcA>? NUfFZZNRTE2VTx?= M1vLNmlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFizJIx6e2mwZTCxOEBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= M{jheVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4OUKxN|Y4Lz5zNkmyNVM3PzxxYU6=
GM15850 MnjNT4lv[XOnIFHzd4F6 M1zlWVIvPSEQvF2= MVS5OkBp Mm\TSG1UVw>? NY\hc5Y{UW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFUh[WOndInsZZRqd25ib3[gSnhPKGenbnW= MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjl{MUO2O{c,OTZ7MkGzOlc9N2F-
GM15850 MkTWT4lv[XOnIFHzd4F6 NHrUN4YzNjVizszN NV3jNHdvQTZiaB?= NULVUGU1TE2VTx?= Mmj5TY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEGyJIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n NYDDZVdmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[5NlE{PjdpPkG2PVIyOzZ5PD;hQi=>
GM15850 MXvLbY5ie2ViQYPzZZk> MlX5Nk42KM7:TR?= M1jNbFk3KGh? MYPEUXNQ MXnJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKMzDsfZNqdmViOTDhZ4V1gWyjdHnvckBw\iCIWF6g[4Vv\Q>? M1u5eVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4OUKxN|Y4Lz5zNkmyNVM3PzxxYU6=
GM15850 NF3VXopMcW6jc3WgRZN{[Xl? M{T1VVIvPSEQvF2= M3;relk3KGh? M1XpOWROW09? MnXqTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEigZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? NFm0NoU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkmyNVM3Pyd-MU[5NlE{Pjd:L3G+
GM15850 M1\V[GtqdmG|ZTDBd5NigQ>? NHn1[XMzNjVizszN MoL5PVYhcA>? MUDEUXNQ NXf2[21KUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFE3KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l NGPIRWQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkmyNVM3Pyd-MU[5NlE{Pjd:L3G+
U937 NX\3TYZxTnWwY4Tpc44hSXO|YYm= MoH6OUDPxE1? MlfQNlQhcA>? M4PGXGROW09? MV3D[YxtKGO7Y3zlJIFzemW|dDDifUBi[2O3bYXsZZRqd25iYYSgV{9IOi:PIIDoZZNm NGm5Xpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{CwOFcyQCd-MUewNFQ4OTh:L3G+
H661 M1TLWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDyUndiPDhiaB?= M3;GSWlEPTB;MTFOwG0> M3nhbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUW3NFA6Lz5zN{G1O|AxQTxxYU6=
U937 M122W2Z2dmO2aX;uJGF{e2G7 MVi1JO69VQ>? NYTkPXhPOjRiaB?= NY\0TY5qTE2VTx?= NWDtbnVpUW6lcnXhd4UhcW5iaHnzeI9v\SCKMzDhZ4V1gWyjdHnvci=> NEL0W|k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{S0O|c2OCd-MUe0OFc4PTB:L3G+
U937 NEe2[mFHfW6ldHnvckBCe3OjeR?= MnXFNUDPxE1? NWP5eodTOjRiaB?= NIDOcpVFVVOR NVTicldDTW[oZXP0JI9vKGGucHjhJJR2[nWuaX6gZYNmfHmuYYTpc44> NVS3SJZ4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0OFc4PTBpPkG3OFQ4PzVyPD;hQi=>
RAW264.7 NFznT|lHfW6ldHnvckBCe3OjeR?= MVWxNEDPxE1? NHvXO5ozPGh? NFW5XJV4[XSnch?= NFXZPZBKdmirYnn0bY9vKG:oIFzQV{1{fGmvdXzheIVlKFSQRnHsdIhiKHC{b3T1Z5Rqd25id3n0bEBKSzVyIH;mJFAvPzZizszN MmP5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2N{e1NVgoRjF5NEe3OVE5RC:jPh?=
RAW264.7 MlfvSpVv[3Srb36gRZN{[Xl? NHjSR4UyOCEQvF2= MmP1NlRp MWj3ZZRmeg>? M3\1VmlvcGmkaYTpc44hd2ZiTGDTMZN1cW23bHH0[YQhVk9icILv[JVkfGmxbjD3bZRpKEmFNUCgc4YhOS56ODFOwG0> MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR5N{WxPEc,OTd2N{e1NVg9N2F-
SC9 NUTSTZBFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\ybFQ5KGh? M{jiNGlEPTB;MD62NFYh|ryP NHy4Soc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{WwO|IyQSd-MUe1NFczOTl:L3G+
ST14A MYjGeY5kfGmxbjDBd5NigQ>? MWW1JI5O MnrCO|IhcA>? MUHJcoNz\WG|ZTDpckBTTVOWL17SV2YhdVKQQTDlfJBz\XO|aX;u MlvUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3NkW5PVMoRjF5NU[1PVk{RC:jPh?=
ST14A MVHGeY5kfGmxbjDBd5NigQ>? NX3C[|VvPSCwTR?= MmLhO|IhcA>? Mo[3TY5kemWjc3WgbY4hTTKIMTDtVm5CKGW6cILld5Nqd25? MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzV4NUm5N{c,OTd3NkW5PVM9N2F-
PANC1 NE[2eFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LOWVEh|ryP MYDJR|UxRTBwNEWg{txO NVnFSWNTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1PFg4PDRpPkG3OVg5PzR2PD;hQi=>
PANC1 NWjuNlBDTnWwY4Tpc44hSXO|YYm= MUSxJO69VQ>? NHXQNogzPCCq M3K0NWlv[3KnYYPlJIlvKHB{MWfBSlEwS0mSMTDn[Y5mKGW6cILld5Nqd25? NIHsOnU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{W4PFc1PCd-MUe1PFg4PDR:L3G+
PANC1 MmCxSpVv[3Srb36gRZN{[Xl? MkO4NUDPxE1? Mn3TNlQhcA>? M2nsdmlv[3KnYYPlJIlvKHB{N3vpdFEh\2WwZTDlfJBz\XO|aX;u NUPMfIIzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1PFg4PDRpPkG3OVg5PzR2PD;hQi=>
PT45 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PRN2lEPTB;NDFOwG0> M3zOTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUi4O|Q1Lz5zN{W4PFc1PDxxYU6=
ACHN Ml7iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPpOZlTOjFiaB?= NXHROnpuT0l3ME2wMlY2KM7:TR?= M4PyfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5Nk[yOlA3Lz5zN{[2NlYxPjxxYU6=
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A549 MWXDfZRwfG:6aXOgRZN{[Xl? Mme3O|IhcA>? MnXQR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{BwfmW{ZYjwdoV{e2mwZzDISGFEKHerdHigTWM2OCCxZjCxMlgh|ryP NH3LTVk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUC4NFYzQSd-MkGwPFA3Ojl:L3G+
CAL27 MUXDfZRwfG:6aXOgRZN{[Xl? NF74Ooo4OiCq MmLUR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR2FNOjdiY3XscJMhd3[ncnX4dJJme3OrbnegSWdHWiC5aYToJGlEPTBib3[gN{4zKM7:TR?= NGLBcWI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUC4NFYzQSd-MkGwPFA3Ojl:L3G+
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SKBR3 M3fYWmN6fG:2b4jpZ{BCe3OjeR?= NHjwUpE4OiCq MXfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTT2JTOyClZXzsd{BwfmW{ZYjwdoV{e2mwZzDISXIzKHerdHigTWM2OCCxZjCyMlYh|ryP MnL1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFyOEC2NlkoRjJzMEiwOlI6RC:jPh?=
SKOV3 NW\ocJNLS3m2b4TvfIlkKEG|c3H5 M4XVS|czKGh? MXLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTT29XOyClZXzsd{BwfmW{ZYjwdoV{e2mwZzDISXIzKHerdHigTWM2OCCxZjCyMlIh|ryP NYrt[WdMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGwPFA3OjlpPkKxNFgxPjJ7PD;hQi=>
COR-L23 NU\kVmxnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnjO4VxOTBizszN M4fjWVczKGh? NXfjXFFsTE2VTx?= NIe0eY9IUTVyPUGuNUDPxE1? MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB6ME[0O{c,OjFyOEC2OFc9N2F-
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HCT116 MVPLbY5ie2ViQYPzZZk> MWSzNEDPxE1? MUGzNEBp M3fpXGROW09? NI\HUGdKdmirYnn0bY9vKG:oIFjERWM3KGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBidHCqYT30eYJ2dGmwIHHj[ZR6dGG2aX;u NUT2UpZyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGwPFA3PDdpPkKxNFgxPjR5PD;hQi=>
HCT116 NGf2Z|BMcW6jc3WgRZN{[Xl? NV;sbIRqOzBizszN Mlr4N|AhcA>? NIfRdotFVVOR MVfJcohq[mm2aX;uJI9nKEiGQVOxJIF{e2W|c3XkJIF{KGmwZIXjeIlwdiCxZjDobZN1d26nIFizT|kh[WOndInsZZRqd25? M4PQN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMEiwOlQ4Lz5{MUC4NFY1PzxxYU6=
U937 NFTQOHBMcW6jc3WgRZN{[Xl? NGrZSGs2KM7:TR?= MVGyOEBp MYDEUXNQ M4HFd2lvcGmkaYTpc44hd2ZiaHnzeI9v\SCjY3X0fYx1emGwc3\ldoF{\SCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDv[kBi[2W2eXzheIlwdiCxZjDobZN1d26nIFizJIF1KEt7 M1jhc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMkmyOFkzLz5{MUK5NlQ6OjxxYU6=
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U937 NEf4V3BMcW6jc3WgRZN{[Xl? NU\0S5N1PSEQvF2= M4m3cVE2KG2rbh?= MnfXSG1UVw>? NY\QOFNTUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGirc4TvcoUhUDNiYXPleJlt[XSrb36gcIV3\Wx? NXPkd41vRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGyPVI1QTJpPkKxNlkzPDl{PD;hQi=>
A2780 M3zXVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYm5OkBp MnHySG1UVw>? Ml7hTWM2OD1zLk[yJO69VQ>? MmGxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF4M{S0N|AoRjJzNkO0OFMxRC:jPh?=
COLO205 NXnRWml{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUW5OkBp M3nBTGROW09? NHjKWWVKSzVyPUKuNVIh|ryP NH\QOm89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MU[zOFQ{OCd-MkG2N|Q1OzB:L3G+
Hep3B NVSzfHltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWWxPVBDPDhiaB?= M1\DTmROW09? MYjHTVUxRTFwMkGg{txO MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTdzMkG0Okc,OjF5MUKxOFY9N2F-
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BT549 NHPaZXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVflWWtqPi5{IN88US=> M37QSlczKGh? NF3PUFVFVVOR NWrpbVZ5T0l3ME2xMlMh|ryP MnPmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2M{W2OlkoRjJ{NEO1OlY6RC:jPh?=
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NCI-ADR-RES M1;ZV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXW2MlIh|ryP MlHsO|IhcA>? MWTEUXNQ NYjoToo5T0l3ME2wMlE3KM7:TR?= NFL1SHg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSzOVY3QSd-MkK0N|U3Pjl:L3G+
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NCI-H322M M17GXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW[2MlIh|ryP MkHGO|IhcA>? MVzEUXNQ NIHhd4lIUTVyPUCuO|kh|ryP M{fySVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEO1OlY6Lz5{MkSzOVY3QTxxYU6=
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OVCAR3 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfLOk4zKM7:TR?= MWW3NkBp NEDJRpZFVVOR Mor3S2k2OD1zLkOg{txO MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR|NU[2PUc,OjJ2M{W2Olk9N2F-
OVCAR4 NYfMdJJPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;LOk4zKM7:TR?= NH7qNIM4OiCq MlLvSG1UVw>? M3HJXmdKPTB;NDFOwG0> NHjlRW89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSzOVY3QSd-MkK0N|U3Pjl:L3G+
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OVCAR8 M3\sUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnriOk4zKM7:TR?= MVK3NkBp MV3EUXNQ MmS2S2k2OD1yLkWg{txO NWm1U4VQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0N|U3PjlpPkKyOFM2PjZ7PD;hQi=>
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SF268 NHjCNW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXW2MlIh|ryP MXu3NkBp NIjEZnlFVVOR M{XUbWdKPTB;MT62JO69VQ>? M33iWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEO1OlY6Lz5{MkSzOVY3QTxxYU6=
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UACC62 M1fWfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PKfVYvOiEQvF2= NUjkUXp4PzJiaB?= MmTjSG1UVw>? M3HPdWdKPTB;MD60JO69VQ>? MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR|NU[2PUc,OjJ2M{W2Olk9N2F-
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Hep3B MlrDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjnb3E1QCCq NFfHZmhFVVOR NXzRd4NlT0l3ME2wMlY6KM7:TR?= MkW0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2M{m4OlMoRjJ{NEO5PFY{RC:jPh?=
BE(2)-C M17p[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHez[2g4OiCq NYns[WUxTE2VTx?= NGHHVndKSzdyPUKg{txO M3rCW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OUOyN|E3Lz5{MkmzNlMyPjxxYU6=
Bel7402 NUjBUIF[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1ixVlczKGh? M3PU[GROW09? M{\RUmdKQTB;MUeg{txO Mkf1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyNkGzO|YoRjJ|ME[xN|c3RC:jPh?=
Bel7404 MorIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo[1O|IhcA>? MYrEUXNQ NULxUXdET0l7ME2xPEDPxE1? M4j5OVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|ME[xN|c3Lz5{M{C2NVM4PjxxYU6=
BGC823 NWfvWZVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzReZI4OiCq MVHEUXNQ MVLHTVkxRTdwNTFOwG0> NYH4[Y9FRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwOlE{PzZpPkKzNFYyOzd4PD;hQi=>
MGC803 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1faPVczKGh? MWnEUXNQ NUXrXVIzT0l7ME2xNE45KM7:TR?= M2nRVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|ME[xN|c3Lz5{M{C2NVM4PjxxYU6=
SGC7901 MnTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzMO|IhcA>? NXfG[4M1TE2VTx?= MVjHTVkxRTlwNDFOwG0> NG\N[FM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{C2NVM4Pid-MkOwOlE{PzZ:L3G+
SKHEP1 NX;vO5RCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXXclU4OiCq MnqzSG1UVw>? NY[4OY9nT0l7ME2xO{DPxE1? M3\JcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|ME[xN|c3Lz5{M{C2NVM4PjxxYU6=
SMMC7721 NFrpUI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LKdVczKGh? M2PFWGROW09? NEHNRlNIUTlyPUKwJO69VQ>? MoTQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyNkGzO|YoRjJ|ME[xN|c3RC:jPh?=
NUGC3 MmXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfxPVdjOTBizszN NXz3[4lZT0l;Mj65OEDPxE1? M4\SNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MU[zN|MzLz5{M{G2N|M{OjxxYU6=
A2780 CisR MoHFT4lv[XOnIFHzd4F6 M1XpfVE5KGh? NUfVSI11UW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlQ1KM7:TR?= MmXMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{NUK2NFMoRjJ|MkWyOlA{RC:jPh?=
CAL27 sens MU\LbY5ie2ViQYPzZZk> NVPwN5pDOThiaB?= M2P3eWlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD6zOkDPxE1? MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ3Mk[wN{c,OjN{NUK2NFM9N2F-
CAL27 CisR NFjwPYtMcW6jc3WgRZN{[Xl? NUnXeIliOThiaB?= MnK2TY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLk[xJO69VQ>? MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ3Mk[wN{c,OjN{NUK2NFM9N2F-
KYSE-510 CisR Mne2T4lv[XOnIFHzd4F6 NXnKRo9iOThiaB?= NYrTNotLUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlU6KM7:TR?= NGPGPYc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{K1NlYxOyd-MkOyOVI3ODN:L3G+
KYSE-510 sens M1L0dWtqdmG|ZTDBd5NigQ>? M1fWU|E5KGh? Mm\hTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkeg{txO NHjVVVc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{K1NlYxOyd-MkOyOVI3ODN:L3G+
MDA-MB-231 sens NXL0bmVxU2mwYYPlJGF{e2G7 NWTNUm1uOThiaB?= M3PlTmlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1? M3n0cFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MkWyOlA{Lz5{M{K1NlYxOzxxYU6=
MDA-MB-231 CisR NHXiSVdMcW6jc3WgRZN{[Xl? NVLFcpRsOThiaB?= MmTDTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLk[xJO69VQ>? MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ3Mk[wN{c,OjN{NUK2NFM9N2F-
ES2 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUOzNIxLPDhiaB?= NITVS3FFVVOR NF[5VoVKSzVyPUGyMlch|ryP NITUSZk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S5N|Q1QSd-MkO0PVM1PDl:L3G+
MDA-MB-231 M1zDXGtqdmG|ZTDBd5NigQ>? MlTmNVAh|ryP NHPUbI8{OCCvaX6= M3zhXmROW09? Mnn0TY5pcWKrdHnvckBw\iCKRFHDNoE> Mm\LQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2OUO0OFkoRjJ|NEmzOFQ6RC:jPh?=
MDA-MB-231 NIPtcWxMcW6jc3WgRZN{[Xl? M2O1flEh|ryP M1rjeVI1KGh? NUO3WmlbTE2VTx?= M2\vdGlvcGmkaYTpc44hd2ZiSFTBR|Yh[XO|ZYPz[YQh[XNiYXPleJlt[XSrb36gcIV3\Wy|IH;mJJR2[nWuaX6= MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzR7M{S0PUc,OjN2OUO0OFk9N2F-
HS68 M3vs[2N6fG:2b4jpZ{BCe3OjeR?= MV:xNEDPxE1? NUTINFVlPzJiaB?= M{ntbGROW09? MU\JR|UxRTRwNjFOwG0> MkWwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3N{C1OFIoRjJ|NUewOVQzRC:jPh?=
MEF NFm1coVEgXSxdH;4bYMhSXO|YYm= MoHyNVAh|ryP M2i0SVczKGh? NGSxVJFFVVOR MUjJR|UxRTRwNDFOwG0> M2P0SFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NUewOVQzLz5{M{W3NFU1OjxxYU6=
BGC823 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfEUXNQ M3vNVWdKPTB;Mz6wPUDPxE1? NEfLWmo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[wNVcxPid-MkO2NFE4ODZ:L3G+
High5 NVnxVJhmU2mwYYPlJGF{e2G7 NX7ZUZg{OjRiaB?= MlnxTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCKRFHDOkB4cXSqIFnDOVAhd2ZiMD6wPUDPxE1? NYTicIU1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NFI2OjNpPkKzOlAzPTJ|PD;hQi=>
High5 NVvjOmF{U2mwYYPlJGF{e2G7 NU\ubVNDOjRiaB?= MYDJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEiGQVOxJJdqfGhiSVO1NEBw\iByLkGyJO69VQ>? MlHNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MEK1NlMoRjJ|NkCyOVI{RC:jPh?=
High5 MWjLbY5ie2ViQYPzZZk> M{fMRVI1KGh? M1XOcWlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiSFTBR|Mhf2m2aDDJR|UxKG:oIECuNVch|ryP NILFWIc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[wNlUzOyd-MkO2NFI2OjN:L3G+
A549 NFf1PHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfwOYJFVVOR NXXKZWVbUUN3ME2xMlA4QSEQvF2= NIjMSVM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[0OFIyOCd-MkO2OFQzOTB:L3G+
HCT116 NWnWUXhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjJW29DTE2VTx?= NVWy[m82UUN3ME2wMlc2PyEQvF2= MkLRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4NESyNVAoRjJ|NkS0NlExRC:jPh?=
K562 M2fR[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlP6SG1UVw>? NWjsZnE1UUN3ME2wMlY1PSEQvF2= MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ2NEKxNEc,OjN4NESyNVA9N2F-
GBC-SD MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVu1JO69VQ>? M3;WZVczKGh? M33q[WROW09? M1mzV2lEPTB;MUSuPEDPxE1? NX7QTFZyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO3NFczPjBpPkKzO|A4OjZyPD;hQi=>
HGC27 NViwOmVvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PZdFUh|ryP Ml76O|IhcA>? M1f3UGROW09? MYDJR|UxRTVwNDFOwG0> MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzdyN{K2NEc,OjN5MEeyOlA9N2F-
HL60 NYi3Nmg1U2mwYYPlJGF{e2G7 NFvW[pE2KM7:TR?= Mk\1NlQhcA>? MV\EUXNQ NUnlN5lKUW6qaXLpeIlwdiCxZjDISGFE MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzdyN{K2NEc,OjN5MEeyOlA9N2F-
Vero NEXaOmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLu[3RXPzJiaB?= NVTKTIt7TE2VTx?= M{TTbGlEPTB;MD65JO69VQ>? NEP3XmU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{e4OlQ2Oid-MkO3PFY1PTJ:L3G+
NCI60 Ml\kR5l1d3SxeHnjJGF{e2G7 M1jndlQ5KGh? MUHEUXNQ NV3sZld[T0l;MD61N{DPxE1? MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDBzNUOyO{c,OjRyMUWzNlc9N2F-
SW620 NHf6OnJEgXSxdH;4bYMhSXO|YYm= MojTOFghcA>? M3vkfmROW09? NIjuTnlIUT1yLkW0JO69VQ>? NFm5cZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NECxOVMzPyd-MkSwNVU{Ojd:L3G+
U251 M4LwXmN6fG:2b4jpZ{BCe3OjeR?= NYrTUnpoPDhiaB?= MmrSSG1UVw>? NHuxS5JIUT1zLkWzJO69VQ>? NUW5R25FRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwNVU{OjdpPkK0NFE2OzJ5PD;hQi=>
KM12 NYLtNVgyS3m2b4TvfIlkKEG|c3H5 NF:4V2k1QCCq Mnr1SG1UVw>? MkHvS2k:OS56ODFOwG0> NF\KNpY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NECxOVMzPyd-MkSwNVU{Ojd:L3G+
Hs578T MWrDfZRwfG:6aXOgRZN{[Xl? MUC0PEBp M1WxUmROW09? NYXvd2tFT0l;ND64N{DPxE1? M336W|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEG1N|I4Lz5{NECxOVMzPzxxYU6=
MDA-MB-231 M{XWfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\4eFQ5KGh? MYLJR|UxRTBwMU[g{txO M17icVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEm1NFE3Lz5{NEC5OVAyPjxxYU6=
MCF7 NWHBNIljT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljwOFghcA>? NVHjN3JpT0l;MD60OUDPxE1? MlHxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzMUm1OVUoRjJ2MUG5OVU2RC:jPh?=
MDA-MB-435 NVm0fHp3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWi0PEBp NUiwfIlRT0l;MD64PEDPxE1? M4nxdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUG5OVU2Lz5{NEGxPVU2PTxxYU6=
AsPC1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlT3N|Ah|ryP MoGzOFghcA>? NVroSohXTE2VTx?= Mm\4TWM2OD1|Lk[2JO69VQ>? M1LWelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUi1N|c5Lz5{NEG4OVM4QDxxYU6=
Jurkat E6.1 NVzuNHloU2mwYYPlJGF{e2G7 M3vk[|IhcA>? M3\yNGROW09? M3ryU2lvcGmkaYTpc44hd2ZiSFTBR|Qhf2m2aDDJR|UxKG:oIECuNFQh|ryP NWH1XYlyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyOlE5PjJpPkK0NlYyQDZ{PD;hQi=>
KG1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXj1c4hxPDhiaB?= M4\NNWlEPTB;MT6xOUDPxE1? NFLBTVY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWyOVAxOyd-MkS1NlUxODN:L3G+
HEL MlPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XiN|Q5KGh? M{fwOWROW09? NF\mbmlKSzVyPUCuOFkh|ryP M4mwc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2Nkm0NFU2Lz5{NE[5OFA2PTxxYU6=
HSC3 MWPDfZRwfG:6aXOgRZN{[Xl? Mo\SNVIhcA>? MVnEUXNQ MXPJR|UxRTBwN{Gg{txO NV\GVmNCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3OlY2PjBpPkK0O|Y3PTZyPD;hQi=>
HT-29 NIjrOVBEgXSxdH;4bYMhSXO|YYm= M{XM[|EzKGh? M3HQU2ROW09? MkL6TWM2OD1yLkeyJO69VQ>? MlHPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5Nk[1OlAoRjJ2N{[2OVYxRC:jPh?=
KB NWH1RnFwS3m2b4TvfIlkKEG|c3H5 MnjJNVIhcA>? M3:0OGROW09? MVvJR|UxRTBwN{Wg{txO MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd4NkW2NEc,OjR5Nk[1OlA9N2F-
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