Vorinostat (SAHA)

For research use only. Not for use in humans.

目录号:S1047 别名: MK0683, Suberoylanilide hydroxamic acid 中文名称:伏立诺他

Vorinostat (SAHA) Chemical Structure

CAS No. 149647-78-9

Vorinostat (suberoylanilide hydroxamic acid, SAHA, MK0683)是一种HDAC抑制剂,无细胞试验中IC50为~10 nM。Vorinostat 会抑制高效的HPV-18 DNA扩增。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1558.77 现货
RMB 1198.15 现货
RMB 1794.86 现货
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客户使用Selleck生产的Vorinostat (SAHA)发表文献418篇:

产品安全说明书

HDAC抑制剂选择性比较

生物活性

产品描述 Vorinostat (suberoylanilide hydroxamic acid, SAHA, MK0683)是一种HDAC抑制剂,无细胞试验中IC50为~10 nM。Vorinostat 会抑制高效的HPV-18 DNA扩增。
特性 Vorinostat是广谱HDAC活性抑制剂,抑制I和II类酶 。
靶点
HDAC [1]
(Cell-free assay)
~10 nM
体外研究

Vorinostat是小分子量(<300)线性肟酸,抑制HDAC活性,包括乙酰化组蛋白和非组蛋白的积累,抑制培养细胞的增殖,且抑制肿瘤生长。Vorinostat通过结合到酶的活性位点而抑制 HDAC活性。Vorinostat 抑制多种转化细胞增殖(包括 淋巴瘤,多发性骨髓瘤,白血病,和非小细胞肺癌),与对照组相比抑制生长达50% 时的浓度为0.5 到10μM。Vorinostat作用于淋巴瘤和白血病细胞,包括 Burkitt, B-细胞急性淋巴细胞白血病 (B-ALL), MCL, DLBCL, ATL和T-细胞,不同程度抑制细胞增殖。除了抑制转化细胞增殖, Vorinostat 也抑制正常细胞增殖,通过比较Vorinostat 作用于一组细胞系–正常人非纤维细胞(WI-38)和 SV40巨大T抗原转化WI-38(VA-13细胞)而得到证明。Vorinostat 抑制两种类型细胞增殖,这种作用存在剂量依赖性。但发现Vorinostat 对转化细胞具有选择毒性,包括使肿瘤细胞死亡,而对正常细胞只起抑制作用,不会使其死亡。[1] Genistein 和Vorinostat 联用效果比5-aza和Vorinostat 联用作用于诱导细胞死亡有效很多。Genistein和Vorinostat联用作用于ARCaP-E使增殖降低 80 %,作用于ARCaP-M细胞,增殖降低60 %以上。Genistein和Vorinostat 联用抑制细胞增殖具有协同效应。作用于ARCaP-E 细胞(820个基因 诱导和1046个基因抑制) ARCaP-M 细胞,Vorinostat比Genistein 影响更多基因。[2] Vorinostat作用于肿瘤细胞表面,提高Fas蛋白水平,这种作用存在剂量依赖性,且按0.75 μM剂量处理,提高达到一个稳定水平。[3] Vorinostat 抑制肿瘤细胞生长,包括NB4, H460 和HCT-116,IC50分别为0.7μM, 3.4μM和1.2 μM。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
H1299 NELQTXVMcW6jc3WgRZN{[Xl? MnTNNlAhdWmw M{S3R2ROW09? NYnxOmZQUW6qaXLpeI9zgSCjY4Tpeol1gSCjZ3HpcpN1KEiGQVOg[Y57gW2nIIfpeIghUUN3MDDv[kAxNjF7NDFOwG0> NH2wVFQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNEWyNVQzOid-MUS1NlE1OjJ:L3G+
HT1080 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrSSm02PzJiaB?= NF[3WoVFVVOR NGTzbWlKSzVyPUKuOEDPxE1? MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjJ5MEG3OUc,OTJ{N{CxO|U9N2F-
K562 MmTZT4lv[XOnIFHzd4F6 M2H5R|YhcA>? MoroSG1UVw>? M3T6cGlvcGmkaYTpc44hd2ZiaIXtZY4hcGm|dH;u[UBl\WGlZYT5cIF{\SBqbXn4eJVz\SCxZjDISGFEOSCjbnSgTGRCSzJrIIfpeIghUUN3MDDv[kAxNjBzIN88US=> NV;Oemh2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK0NVk{QDBpPkGyOFE6OzhyPD;hQi=>
A20 NV\rR3V[U2mwYYPlJGF{e2G7 MnzVNUBp NYLyUoJPTE2VTx?= MWjhcpRqNUiGQVOxJIFkfGm4aYT5JJdqfGhiSVO1NEBw\iByLkGxNkDPxE1? NGPWVWk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUm2NFQ5QSd-MUG5OlA1QDl:L3G+
Friend leukemic cell MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHUcWM2OCEQvF2= NX3xRXJYPzJiaB?= MX;EUXNQ MVXJR|UxRTBwOUmg{txO NVTmdIx5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUKxNFk6OTNpPkGyNVA6QTF|PD;hQi=>
H1299 NHfQV4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDlVFE4OiCq MXTEUXNQ NWiySVJQUUN3ME23MlI1KM7:TR?= NIfmZVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNEWyNVQzOid-MUS1NlE1OjJ:L3G+
HeLa NWHyTlhYU2mwYYPlJGF{e2G7 MVWzNEBucW5? M2PTb2lvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDh[4FqdnO2IHjpd5RwdmViZHXhZ4V1gWyjc3Wge4l1cCCLQ{WwJI9nKDBwMkig{txO NYfw[VJGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW2NFM6PDlpPkG1OlA{QTR7PD;hQi=>
LOX-IMVI NYPJW2pnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYm0PEBp MnfxTWM2OD1zLkOg{txO NGPOe2o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUexOVQ4OCd-MUW3NVU1PzB:L3G+
NCI-H226 NVHwZWd6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWC0PEBp NXKxOGFUUUN3ME2yMlYh|ryP NF3RbXc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUexOVQ4OCd-MUW3NVU1PzB:L3G+
RXF-631L Mk\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXmzW3M2PDhiaB?= MoK1TWM2OD1{IN88US=> NYPEcY9XRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW3NVU1PzBpPkG1O|E2PDdyPD;hQi=>
SNB-78 NF73bFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\vOWM1QCCq MVTJR|UxRTF4IN88US=> NULsO4hJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW3NVU1PzBpPkG1O|E2PDdyPD;hQi=>
St-4 NUD2c2EzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3DfFY1QCCq NYjCeGVZUUN3ME21MlIh|ryP Mn20QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV5MUW0O|AoRjF3N{G1OFcxRC:jPh?=
ARP1 MUDGeY5kfGmxbjDBd5NigQ>? NEfYNpIzKM7:TR?= MkT6OkBp MkHkTY5lfWO2aX;uJI9nKFB{MWfBSlEh\2WwZTDlfJBz\XO|aX;u NEjK[IY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNEezOFgxPid-MUS3N|Q5ODZ:L3G+
CEM MXXLbY5ie2ViQYPzZZk> MUOxJIg> MV3EUXNQ MoizTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkOzJO69VQ>? NHjMUpg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkSyNFA3PCd-MU[0NlAxPjR:L3G+
HCT15 NXXCN5lrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rNb|Q5KGh? NHPIbZpIUTVyPUCuPFIh|ryP NWDFRZlRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[3NlMzOjdpPkG2O|I{OjJ5PD;hQi=>
NCI-H23 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnuVmQ1QCCq NVPlTGZKT0l3ME2wMlkzKM7:TR?= M3O1elxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4N{KzNlI4Lz5zNkeyN|IzPzxxYU6=
GM15850 MlHKT4lv[XOnIFHzd4F6 MYqyMlUh|ryP NGfafHU6PiCq NEniTmFFVVOR NWHKRlg5UW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFE1KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l NVXpemZ[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[5NlE{PjdpPkG2PVIyOzZ5PD;hQi=>
GM15850 NXexSnlDU2mwYYPlJGF{e2G7 NI[0RWEzNjVizszN NITocZM6PiCq MWfEUXNQ NFvRc3VKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgOUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= Mon5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ7MkGzOlcoRjF4OUKxN|Y4RC:jPh?=
GM15850 NVTlR25lU2mwYYPlJGF{e2G7 Mlm3Nk42KM7:TR?= NFvUVGw6PiCq M1ThcWROW09? M2PP[2lvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTCxNkBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjl{MUO2O{c,OTZ7MkGzOlc9N2F-
GM15850 NFrFVoVMcW6jc3WgRZN{[Xl? NULMZoRiOi53IN88US=> MkLOPVYhcA>? Moj0SG1UVw>? NGX1UmRKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIN{BtgXOrbnWgPUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= NXW0Z2h2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[5NlE{PjdpPkG2PVIyOzZ5PD;hQi=>
GM15850 M3X3eGtqdmG|ZTDBd5NigQ>? NEDObHYzNjVizszN NV3FN4c1QTZiaB?= NWrpeGlTTE2VTx?= NEO0[2FKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgPEBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= MlSxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ7MkGzOlcoRjF4OUKxN|Y4RC:jPh?=
GM15850 MmHqT4lv[XOnIFHzd4F6 NIG4Xm4zNjVizszN M{LZO|k3KGh? MX3EUXNQ MnTmTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEG2JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n MnvOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ7MkGzOlcoRjF4OUKxN|Y4RC:jPh?=
U937 MoftSpVv[3Srb36gRZN{[Xl? Mm\5OUDPxE1? NE\lVGkzPCCq NWXqOZFjTE2VTx?= NV[5VZU{S2WubDDjfYNt\SCjcoLld5Qh[nliYXPjeY12dGG2aX;uJIF1KFNxR{KvUUBxcGG|ZR?= NHPzUJE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{CwOFcyQCd-MUewNFQ4OTh:L3G+
H661 M36yOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYm0PEBp M2GxV2lEPTB;MTFOwG0> NGrkU5c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G1O|AxQSd-MUexOVcxODl:L3G+
U937 MVvGeY5kfGmxbjDBd5NigQ>? M2LINFUh|ryP MUOyOEBp M2\ZXmROW09? NY\YWHV4UW6lcnXhd4UhcW5iaHnzeI9v\SCKMzDhZ4V1gWyjdHnvci=> NWPUZ|NJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0OFc4PTBpPkG3OFQ4PzVyPD;hQi=>
U937 NHnMRldHfW6ldHnvckBCe3OjeR?= M2CzdlEh|ryP MmTKNlQhcA>? MXPEUXNQ NHWze4lG\m[nY4Sgc44h[WyyaHGgeJVjfWyrbjDhZ4V1gWyjdHnvci=> M4rSOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NES3O|UxLz5zN{S0O|c2ODxxYU6=
RAW264.7 NH3vOYpHfW6ldHnvckBCe3OjeR?= MWmxNEDPxE1? Mn\TNlRp NVy2ZXA3f2G2ZYK= NELFbJVKdmirYnn0bY9vKG:oIFzQV{1{fGmvdXzheIVlKFSQRnHsdIhiKHC{b3T1Z5Rqd25id3n0bEBKSzVyIH;mJFAvPzZizszN M2XHUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEe3OVE5Lz5zN{S3O|UyQDxxYU6=
RAW264.7 M{DHSGZ2dmO2aX;uJGF{e2G7 M4HRdlExKM7:TR?= NV3sd5FFOjSq Mnjie4F1\XJ? MUDJcohq[mm2aX;uJI9nKEySUz3zeIlufWyjdHXkJG5QKHC{b3T1Z5Rqd25id3n0bEBKSzVyIH;mJFEvQDhizszN NHriSWU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{S3O|UyQCd-MUe0O|c2OTh:L3G+
SC9 NH25OWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHkOFghcA>? M1jEbGlEPTB;MD62NFYh|ryP NVnQWVFjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1NFczOTlpPkG3OVA4OjF7PD;hQi=>
ST14A NEPyRXZHfW6ldHnvckBCe3OjeR?= MkX4OUBvVQ>? NG\1U3Q4OiCq MoXGTY5kemWjc3WgbY4hWkWVVD;OVnNHKG2UTlGg[ZhxemW|c3nvci=> M3TsZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NU[1PVk{Lz5zN{W2OVk6OzxxYU6=
ST14A NXTiTpRETnWwY4Tpc44hSXO|YYm= M17rd|Uhdk1? Mm\3O|IhcA>? NEn6TIJKdmO{ZXHz[UBqdiCHMl[xJI1TVkFiZYjwdoV{e2mxbh?= Mn7oQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3NkW5PVMoRjF5NU[1PVk{RC:jPh?=
PANC1 M3WxNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTF[IFpOSEQvF2= M1ribmlEPTB;MD60OUDPxE1? MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzV6OEe0OEc,OTd3OEi3OFQ9N2F-
PANC1 MYjGeY5kfGmxbjDBd5NigQ>? MVqxJO69VQ>? MXGyOEBp MmK4TY5kemWjc3WgbY4heDJzV1HGNU9EUVBzIHflcoUh\XiycnXzd4lwdg>? M1z3OVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUi4O|Q1Lz5zN{W4PFc1PDxxYU6=
PANC1 NFnkZotHfW6ldHnvckBCe3OjeR?= MYSxJO69VQ>? NXvMOGltOjRiaB?= NWnSWVVEUW6lcnXhd4UhcW5icEK3b4lxOSCpZX7lJIV5eHKnc4Ppc44> M1:0OVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUi4O|Q1Lz5zN{W4PFc1PDxxYU6=
PT45 Mnn5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTRizszN MlrxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3OEi3OFQoRjF5NUi4O|Q1RC:jPh?=
ACHN Ml\3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2q5WlIyKGh? MWPHTVUxRTBwNkWg{txO MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZ4Mk[wOkc,OTd4NkK2NFY9N2F-
PC3 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjJRWdwOjFiaB?= MYLHTVUxRTBwN{Gg{txO NUfn[VdiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2OlI3ODZpPkG3OlYzPjB4PD;hQi=>
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NCI-H460 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmqzOk4zKM7:TR?= NUXSeHFuPzJiaB?= MYDEUXNQ MYXHTVUxRTBwN{mg{txO M2Pje|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEO1OlY6Lz5{MkSzOVY3QTxxYU6=
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OVCAR3 Ml3nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVm1fnZoPi5{IN88US=> MXO3NkBp M3zoXmROW09? MW\HTVUxRTFwMzFOwG0> MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR|NU[2PUc,OjJ2M{W2Olk9N2F-
OVCAR4 M4\XVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4m2PVYvOiEQvF2= NXXU[ZZWPzJiaB?= NXjkVm9yTE2VTx?= MkHsS2k2OD12IN88US=> MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR|NU[2PUc,OjJ2M{W2Olk9N2F-
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Hep3B MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnrOFghcA>? MlvTSG1UVw>? M3r2fmdKPTB;MD62PUDPxE1? M2\3OlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEO5PFY{Lz5{MkSzPVg3OzxxYU6=
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Bel7402 M1uxfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIf4e3Y4OiCq Ml70SG1UVw>? NYe3VFRmT0l7ME2xO{DPxE1? NVLhZ2F3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwOlE{PzZpPkKzNFYyOzd4PD;hQi=>
Bel7404 NHPOS45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLGe2w4OiCq NGTRSWRFVVOR NIG5fXhIUTlyPUG4JO69VQ>? M2fkUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|ME[xN|c3Lz5{M{C2NVM4PjxxYU6=
BGC823 MojNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPOSYxoPzJiaB?= MWXEUXNQ NV3OZpkzT0l7ME23MlUh|ryP M3rLZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|ME[xN|c3Lz5{M{C2NVM4PjxxYU6=
MGC803 NUXaOoRbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPXO|IhcA>? NIHx[JhFVVOR NHPWZWlIUTlyPUGwMlgh|ryP MnPaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyNkGzO|YoRjJ|ME[xN|c3RC:jPh?=
SGC7901 M3n2[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVq3TVdYPzJiaB?= MXnEUXNQ NVWyUlQzT0l7ME25MlQh|ryP NH7VNJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{C2NVM4Pid-MkOwOlE{PzZ:L3G+
SKHEP1 NXS4WYd3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrEcI1VPzJiaB?= NXW1dIFtTE2VTx?= NGq1XJdIUTlyPUG3JO69VQ>? MorxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyNkGzO|YoRjJ|ME[xN|c3RC:jPh?=
SMMC7721 MoLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnUdI5jPzJiaB?= NIr4N29FVVOR M3rC[GdKQTB;MkCg{txO MmDJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyNkGzO|YoRjJ|ME[xN|c3RC:jPh?=
NUGC3 NHHBSIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGO5TpMyOCEQvF2= NV\iTpZtT0l;Mj65OEDPxE1? NFyxPIY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{G2N|M{Oid-MkOxOlM{OzJ:L3G+
A2780 CisR M3jkfWtqdmG|ZTDBd5NigQ>? MWexPEBp NV[3[IVEUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlQ1KM7:TR?= NHf2T409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{K1NlYxOyd-MkOyOVI3ODN:L3G+
CAL27 sens M2nqOGtqdmG|ZTDBd5NigQ>? MUKxPEBp MVvJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwM{[g{txO Mlu2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{NUK2NFMoRjJ|MkWyOlA{RC:jPh?=
CAL27 CisR M4q3N2tqdmG|ZTDBd5NigQ>? M{PablE5KGh? Ml7VTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLk[xJO69VQ>? NWTxSYg4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyOVI3ODNpPkKzNlUzPjB|PD;hQi=>
KYSE-510 CisR MYfLbY5ie2ViQYPzZZk> NXfJUGg4OThiaB?= M3rpcmlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD61PUDPxE1? MkfoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{NUK2NFMoRjJ|MkWyOlA{RC:jPh?=
KYSE-510 sens MmTJT4lv[XOnIFHzd4F6 M{TU[FE5KGh? MmXvTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkeg{txO MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ3Mk[wN{c,OjN{NUK2NFM9N2F-
MDA-MB-231 sens M2P5OWtqdmG|ZTDBd5NigQ>? MnrYNVghcA>? M1faXGlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1? NWXmdIdwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyOVI3ODNpPkKzNlUzPjB|PD;hQi=>
MDA-MB-231 CisR MkG0T4lv[XOnIFHzd4F6 M1nVRVE5KGh? NWXDToppUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlYyKM7:TR?= MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ3Mk[wN{c,OjN{NUK2NFM9N2F-
ES2 NVjqfpJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXROFghcA>? MXHEUXNQ M{OxTmlEPTB;MUKuO{DPxE1? MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzR7M{S0PUc,OjN2OUO0OFk9N2F-
MDA-MB-231 MmLBT4lv[XOnIFHzd4F6 M2G4OVExKM7:TR?= MYOzNEBucW5? M3f5UWROW09? MVfJcohq[mm2aX;uJI9nKEiGQVOyZS=> M3jUV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NEmzOFQ6Lz5{M{S5N|Q1QTxxYU6=
MDA-MB-231 MUDLbY5ie2ViQYPzZZk> MYKxJO69VQ>? NEjsdpIzPCCq MXHEUXNQ MVHJcohq[mm2aX;uJI9nKEiGQVO2JIF{e2W|c3XkJIF{KGGlZYT5cIF1cW:wIHzleoVteyCxZjD0eYJ2dGmw NIrCOZQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S5N|Q1QSd-MkO0PVM1PDl:L3G+
HS68 NWPlOIlZS3m2b4TvfIlkKEG|c3H5 M4TlelExKM7:TR?= MoXuO|IhcA>? MknYSG1UVw>? NX3aVnFZUUN3ME20MlYh|ryP MmfaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3N{C1OFIoRjJ|NUewOVQzRC:jPh?=
MEF MUPDfZRwfG:6aXOgRZN{[Xl? NWjQZXhTOTBizszN MlWwO|IhcA>? MWrEUXNQ M2XZbWlEPTB;ND60JO69VQ>? NWS4[Fh7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1O|A2PDJpPkKzOVcxPTR{PD;hQi=>
BGC823 Mmr5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37oVmROW09? NUnYcJppT0l3ME2zMlA6KM7:TR?= MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZyMUewOkc,OjN4MEG3NFY9N2F-
High5 NI\6Xo9McW6jc3WgRZN{[Xl? MVyyOEBp MnLYTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCKRFHDOkB4cXSqIFnDOVAhd2ZiMD6wPUDPxE1? NYLoNnVsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NFI2OjNpPkKzOlAzPTJ|PD;hQi=>
High5 NWrwdFc1U2mwYYPlJGF{e2G7 NUPmPZRvOjRiaB?= NV\lR2VwUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDISGFEOSC5aYToJGlEPTBib3[gNE4yOiEQvF2= Mo\mQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MEK1NlMoRjJ|NkCyOVI{RC:jPh?=
High5 NFHvVZdMcW6jc3WgRZN{[Xl? NFHJb4UzPCCq NIr3[4tKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjERWM{KHerdHigTWM2OCCxZjCwMlE4KM7:TR?= NH7XXmM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[wNlUzOyd-MkO2NFI2OjN:L3G+
A549 NVHsfnhKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDEUXNQ M4PYcmlEPTB;MT6wO|kh|ryP NV;4NHhIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2OFQzOTBpPkKzOlQ1OjFyPD;hQi=>
HCT116 M3TrNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjVNnVFVVOR NYP3T2xGUUN3ME2wMlc2PyEQvF2= M1[wR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkS0NlExLz5{M{[0OFIyODxxYU6=
K562 NGXzd3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnEUXNQ Mn\yTWM2OD1yLk[0OUDPxE1? MonQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4NESyNVAoRjJ|NkS0NlExRC:jPh?=
GBC-SD MnP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXy1JO69VQ>? NVS0SVdvPzJiaB?= M1nn[mROW09? MYDJR|UxRTF2Lkig{txO M3jq[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|N{C3NlYxLz5{M{ewO|I3ODxxYU6=
HGC27 Ml3hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXe1JO69VQ>? M1PVVFczKGh? NWPrfFB1TE2VTx?= NHXFZXFKSzVyPUWuOEDPxE1? MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzdyN{K2NEc,OjN5MEeyOlA9N2F-
HL60 MnHST4lv[XOnIFHzd4F6 MYS1JO69VQ>? NIjO[YEzPCCq MU\EUXNQ MnfXTY5pcWKrdHnvckBw\iCKRFHD M1T1ZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|N{C3NlYxLz5{M{ewO|I3ODxxYU6=
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NCI60 NGLVVHVEgXSxdH;4bYMhSXO|YYm= Ml:1OFghcA>? NFjKOGNFVVOR MVjHTV0xNjV|IN88US=> MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDBzNUOyO{c,OjRyMUWzNlc9N2F-
SW620 Ml\mR5l1d3SxeHnjJGF{e2G7 NGHLUIY1QCCq MWXEUXNQ MU\HTV0xNjV2IN88US=> NX35fVBlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwNVU{OjdpPkK0NFE2OzJ5PD;hQi=>
U251 NVGzR|VDS3m2b4TvfIlkKEG|c3H5 NUT5TVRxPDhiaB?= NX7HNFhRTE2VTx?= MYrHTV0yNjV|IN88US=> MljhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyMUWzNlcoRjJ2MEG1N|I4RC:jPh?=
KM12 MnzaR5l1d3SxeHnjJGF{e2G7 Ml;yOFghcA>? NGPTXnBFVVOR NEXhVYdIUT1zLki4JO69VQ>? MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDBzNUOyO{c,OjRyMUWzNlc9N2F-
Hs578T MWrDfZRwfG:6aXOgRZN{[Xl? NYfOOHB5PDhiaB?= M2CxVGROW09? MljwS2k:PC56MzFOwG0> NGm3e4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NECxOVMzPyd-MkSwNVU{Ojd:L3G+
MDA-MB-231 NXXFR2l3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LlT|Q5KGh? MlnnTWM2OD1yLkG2JO69VQ>? NXn5b3BuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwPVUxOTZpPkK0NFk2ODF4PD;hQi=>
MCF7 M33qNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PINFQ5KGh? MYnHTV0xNjR3IN88US=> NHnMfJA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEGxPVU2PSd-MkSxNVk2PTV:L3G+
MDA-MB-435 Mn;CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUK0PEBp M{\2cmdKRTBwOEig{txO M1;qZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUG5OVU2Lz5{NEGxPVU2PTxxYU6=
AsPC1 NUnpWVdvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TrRVMxKM7:TR?= MYC0PEBp NInrTVhFVVOR MULJR|UxRTNwNk[g{txO M{X5[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUi1N|c5Lz5{NEG4OVM4QDxxYU6=
Jurkat E6.1 NI\P[mtMcW6jc3WgRZN{[Xl? MXWyJIg> MYrEUXNQ MoraTY5pcWKrdHnvckBw\iCKRFHDOEB4cXSqIFnDOVAhd2ZiMD6wOEDPxE1? MlK3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{NkG4OlIoRjJ2Mk[xPFYzRC:jPh?=
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