Vorinostat (SAHA)

For research use only. Not for use in humans.

目录号:S1047 别名: MK0683, Suberoylanilide hydroxamic acid 中文名称:伏立诺他

Vorinostat (SAHA) Chemical Structure

CAS No. 149647-78-9

Vorinostat (suberoylanilide hydroxamic acid, SAHA, MK0683)是一种HDAC抑制剂,无细胞试验中IC50为~10 nM。Vorinostat 会抑制高效的HPV-18 DNA扩增。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1558.77 现货
RMB 1198.15 现货
RMB 1794.86 现货
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客户使用Selleck生产的Vorinostat (SAHA)发表文献428篇:

产品安全说明书

HDAC抑制剂选择性比较

生物活性

产品描述 Vorinostat (suberoylanilide hydroxamic acid, SAHA, MK0683)是一种HDAC抑制剂,无细胞试验中IC50为~10 nM。Vorinostat 会抑制高效的HPV-18 DNA扩增。
特性 Vorinostat是广谱HDAC活性抑制剂,抑制I和II类酶 。
靶点
HDAC [1]
(Cell-free assay)
~10 nM
体外研究

Vorinostat是小分子量(<300)线性肟酸,抑制HDAC活性,包括乙酰化组蛋白和非组蛋白的积累,抑制培养细胞的增殖,且抑制肿瘤生长。Vorinostat通过结合到酶的活性位点而抑制 HDAC活性。Vorinostat 抑制多种转化细胞增殖(包括 淋巴瘤,多发性骨髓瘤,白血病,和非小细胞肺癌),与对照组相比抑制生长达50% 时的浓度为0.5 到10μM。Vorinostat作用于淋巴瘤和白血病细胞,包括 Burkitt, B-细胞急性淋巴细胞白血病 (B-ALL), MCL, DLBCL, ATL和T-细胞,不同程度抑制细胞增殖。除了抑制转化细胞增殖, Vorinostat 也抑制正常细胞增殖,通过比较Vorinostat 作用于一组细胞系–正常人非纤维细胞(WI-38)和 SV40巨大T抗原转化WI-38(VA-13细胞)而得到证明。Vorinostat 抑制两种类型细胞增殖,这种作用存在剂量依赖性。但发现Vorinostat 对转化细胞具有选择毒性,包括使肿瘤细胞死亡,而对正常细胞只起抑制作用,不会使其死亡。[1] Genistein 和Vorinostat 联用效果比5-aza和Vorinostat 联用作用于诱导细胞死亡有效很多。Genistein和Vorinostat联用作用于ARCaP-E使增殖降低 80 %,作用于ARCaP-M细胞,增殖降低60 %以上。Genistein和Vorinostat 联用抑制细胞增殖具有协同效应。作用于ARCaP-E 细胞(820个基因 诱导和1046个基因抑制) ARCaP-M 细胞,Vorinostat比Genistein 影响更多基因。[2] Vorinostat作用于肿瘤细胞表面,提高Fas蛋白水平,这种作用存在剂量依赖性,且按0.75 μM剂量处理,提高达到一个稳定水平。[3] Vorinostat 抑制肿瘤细胞生长,包括NB4, H460 和HCT-116,IC50分别为0.7μM, 3.4μM和1.2 μM。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
H1299 NGrHW2hMcW6jc3WgRZN{[Xl? MoKwNlAhdWmw MkfGSG1UVw>? NFu0eY9KdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QhUESDQzDlcpp6dWVid3n0bEBKSzVyIH;mJFAvOTl2IN88US=> NFfseWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNEWyNVQzOid-MUS1NlE1OjJ:L3G+
HT1080 NFXNd4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7VfY1kPzJiaB?= M4HqNGROW09? NXni[3hWUUN3ME2yMlQh|ryP MnrNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ{N{CxO|UoRjF{MkewNVc2RC:jPh?=
K562 NEPDV2FMcW6jc3WgRZN{[Xl? Mo[1OkBp NHnlWZJFVVOR Mn7lTY5pcWKrdHnvckBw\iCqdX3hckBpcXO2b37lJIRm[WOndInsZZNmKCivaYj0eZJmKG:oIFjERWMyKGGwZDDISGFEOilid3n0bEBKSzVyIH;mJFAvODFizszN NXrNOXVURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK0NVk{QDBpPkGyOFE6OzhyPD;hQi=>
A20 MYTLbY5ie2ViQYPzZZk> MVexJIg> MoW0SG1UVw>? NI\2N3hidnSrLVjERWMyKGGldHn2bZR6KHerdHigTWM2OCCxZjCwMlEyOiEQvF2= NI\4U5M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUm2NFQ5QSd-MUG5OlA1QDl:L3G+
Friend leukemic cell NEjZUoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjsOVAh|ryP NGj4Zoc4OiCq MnHZSG1UVw>? MXXJR|UxRTBwOUmg{txO NGXpUmE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkGwPVkyOyd-MUKxNFk6OTN:L3G+
H1299 Ml;WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjkR|RnPzJiaB?= MWHEUXNQ Mlr4TWM2OD15LkK0JO69VQ>? NYjJbFdJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUS1NlE1OjJpPkG0OVIyPDJ{PD;hQi=>
HeLa M4PBWmtqdmG|ZTDBd5NigQ>? NEXDcnc{OCCvaX6= M37zeGlvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDh[4FqdnO2IHjpd5RwdmViZHXhZ4V1gWyjc3Wge4l1cCCLQ{WwJI9nKDBwMkig{txO M4Pz[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NkCzPVQ6Lz5zNU[wN|k1QTxxYU6=
LOX-IMVI MmXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7pdHR1PDhiaB?= MorsTWM2OD1zLkOg{txO MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTdzNUS3NEc,OTV5MUW0O|A9N2F-
NCI-H226 M2q3R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVS0PEBp NUGyNJk1UUN3ME2yMlYh|ryP M37MVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3N{G1OFcxLz5zNUexOVQ4ODxxYU6=
RXF-631L NFHCeGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVT6OmJJPDhiaB?= M4nNOWlEPTB;MjFOwG0> Ml7SQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV5MUW0O|AoRjF3N{G1OFcxRC:jPh?=
SNB-78 NHz3SpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIq0SIg1QCCq NYXRRopTUUN3ME2xOkDPxE1? MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTdzNUS3NEc,OTV5MUW0O|A9N2F-
St-4 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3UOFghcA>? NGfabXhKSzVyPUWuNkDPxE1? MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTdzNUS3NEc,OTV5MUW0O|A9N2F-
ARP1 NVH0SpBPTnWwY4Tpc44hSXO|YYm= MUSyJO69VQ>? MkjLOkBp M2r0OWlv\HWldHnvckBw\iCSMkHXRWYyKGenbnWg[ZhxemW|c3nvci=> Mmq3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTR5M{S4NFYoRjF2N{O0PFA3RC:jPh?=
CEM M{H6VGtqdmG|ZTDBd5NigQ>? NVS5SFNHOSCq M3r1[WROW09? M3TkV2lvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD6zN{DPxE1? NUTQ[nNKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[0NlAxPjRpPkG2OFIxODZ2PD;hQi=>
HCT15 M2\5TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnpWmE1QCCq M121OmdKPTB;MD64NkDPxE1? M4\ZWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4N{KzNlI4Lz5zNkeyN|IzPzxxYU6=
NCI-H23 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zkO|Q5KGh? NYHxU5BkT0l3ME2wMlkzKM7:TR?= NF:2XWs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkeyN|IzPyd-MU[3NlMzOjd:L3G+
GM15850 NGXpWGhMcW6jc3WgRZN{[Xl? MoDaNk42KM7:TR?= MV65OkBp NV\ZcIhxTE2VTx?= NETkdYFKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIN{BtgXOrbnWgNVQh[WOndInsZZRqd25ib3[gSnhPKGenbnW= MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjl{MUO2O{c,OTZ7MkGzOlc9N2F-
GM15850 NFHPNHhMcW6jc3WgRZN{[Xl? NV7lcYg5Oi53IN88US=> MmD5PVYhcA>? MoDQSG1UVw>? MVnJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKNDDsfZNqdmViNTDhZ4V1gWyjdHnvckBw\iCIWF6g[4Vv\Q>? Mn\uQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ7MkGzOlcoRjF4OUKxN|Y4RC:jPh?=
GM15850 NIH2[ZpMcW6jc3WgRZN{[Xl? M1XDWFIvPSEQvF2= NEjuW3M6PiCq MY\EUXNQ NEHtWo9KdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgNVIh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NEfjVHQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkmyNVM3Pyd-MU[5NlE{Pjd:L3G+
GM15850 MYDLbY5ie2ViQYPzZZk> MWmyMlUh|ryP MnnYPVYhcA>? MnvySG1UVw>? MWfJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKMzDsfZNqdmViOTDhZ4V1gWyjdHnvckBw\iCIWF6g[4Vv\Q>? MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjl{MUO2O{c,OTZ7MkGzOlc9N2F-
GM15850 MnvjT4lv[XOnIFHzd4F6 NFTQN28zNjVizszN NGnjSZE6PiCq NVPtd|dCTE2VTx?= Mnr6TY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEigZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? M1HPNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4OUKxN|Y4Lz5zNkmyNVM3PzxxYU6=
GM15850 M2fpO2tqdmG|ZTDBd5NigQ>? M1\uS|IvPSEQvF2= NIjlOZU6PiCq MkLISG1UVw>? NHrlPWRKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgNVYh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NVfoTok3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[5NlE{PjdpPkG2PVIyOzZ5PD;hQi=>
U937 NFTnfHFHfW6ldHnvckBCe3OjeR?= NUHic2NDPSEQvF2= MnfQNlQhcA>? NWLs[IZ4TE2VTx?= NWDPRWVoS2WubDDjfYNt\SCjcoLld5Qh[nliYXPjeY12dGG2aX;uJIF1KFNxR{KvUUBxcGG|ZR?= NFvQfm49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{CwOFcyQCd-MUewNFQ4OTh:L3G+
H661 MnX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjx[nI1QCCq NVnNXoxkUUN3ME2xJO69VQ>? Mkn4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzNUewNFkoRjF5MUW3NFA6RC:jPh?=
U937 NGTvTHFHfW6ldHnvckBCe3OjeR?= MlO1OUDPxE1? M3vkPVI1KGh? MYnEUXNQ MWfJcoNz\WG|ZTDpckBpcXO2b37lJGg{KGGlZYT5cIF1cW:w NV3ke2V1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0OFc4PTBpPkG3OFQ4PzVyPD;hQi=>
U937 NGPMWJRHfW6ldHnvckBCe3OjeR?= Mn6wNUDPxE1? MX2yOEBp MknCSG1UVw>? MUfF[oZm[3Rib36gZYxxcGFidIXieYxqdiCjY3X0fYxifGmxbh?= NXj2OmVkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0OFc4PTBpPkG3OFQ4PzVyPD;hQi=>
RAW264.7 NVXJb5o{TnWwY4Tpc44hSXO|YYm= NIfT[40yOCEQvF2= NFrHPVgzPGh? MWD3ZZRmeg>? MUfJcohq[mm2aX;uJI9nKEySUz3zeIlufWyjdHXkJHRPTmGucHjhJJBzd2S3Y4Tpc44hf2m2aDDJR|UxKG:oIECuO|Yh|ryP MnHFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2N{e1NVgoRjF5NEe3OVE5RC:jPh?=
RAW264.7 M2LaWGZ2dmO2aX;uJGF{e2G7 MX6xNEDPxE1? M4fyO|I1cA>? NH7sWFZ4[XSnch?= MXfJcohq[mm2aX;uJI9nKEySUz3zeIlufWyjdHXkJG5QKHC{b3T1Z5Rqd25id3n0bEBKSzVyIH;mJFEvQDhizszN MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR5N{WxPEc,OTd2N{e1NVg9N2F-
SC9 MmHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnVWIRLPDhiaB?= NVvmdZA1UUN3ME2wMlYxPiEQvF2= MnXyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3MEeyNVkoRjF5NUC3NlE6RC:jPh?=
ST14A NUDFUZJITnWwY4Tpc44hSXO|YYm= MlzkOUBvVQ>? MkLWO|IhcA>? MnGwTY5kemWjc3WgbY4hWkWVVD;OVnNHKG2UTlGg[ZhxemW|c3nvci=> NYH2[m1YRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1OlU6QTNpPkG3OVY2QTl|PD;hQi=>
ST14A MXXGeY5kfGmxbjDBd5NigQ>? MWK1JI5O M2PxNVczKGh? M1jLcWlv[3KnYYPlJIlvKEV{RkGgcXJPSSCneIDy[ZN{cW:w NGTieZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{W2OVk6Oyd-MUe1OlU6QTN:L3G+
PANC1 NV\MNWVmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PodlEh|ryP MmHVTWM2OD1yLkS1JO69VQ>? MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzV6OEe0OEc,OTd3OEi3OFQ9N2F-
PANC1 NF3oN3BHfW6ldHnvckBCe3OjeR?= NFfMPYoyKM7:TR?= NFTaNJUzPCCq Mnn3TY5kemWjc3WgbY4heDJzV1HGNU9EUVBzIHflcoUh\XiycnXzd4lwdg>? NFHqbYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{W4PFc1PCd-MUe1PFg4PDR:L3G+
PANC1 MYjGeY5kfGmxbjDBd5NigQ>? MWWxJO69VQ>? MnKzNlQhcA>? NWfDRWNLUW6lcnXhd4UhcW5icEK3b4lxOSCpZX7lJIV5eHKnc4Ppc44> NWS2[|hzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1PFg4PDRpPkG3OVg5PzR2PD;hQi=>
PT45 M1H6NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTRizszN NFTINFk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{W4PFc1PCd-MUe1PFg4PDR:L3G+
ACHN MlzsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHvNlEhcA>? NGf5SXRIUTVyPUCuOlUh|ryP MnTXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4NkK2NFYoRjF5Nk[yOlA3RC:jPh?=
PC3 MkTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULYTodLOjFiaB?= M3P4U2dKPTB;MD63NUDPxE1? NF;LVmQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[2NlYxPid-MUe2OlI3ODZ:L3G+
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HepG2 MkXLT4lv[XOnIFHzd4F6 NWHH[GFPPSEQvF2= NXvzcIN1Pmh? NHXMSnVFVVOR NYTQWJZ1UW6mdXP0bY9vKG:oIFjERWMudWWmaXH0[YQh[WyyaHGteJVjfWyrbjDhZ4V1gWyjdHnvci=> M3zOeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUSzPFQxLz5{MEG0N|g1ODxxYU6=
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COLO205 NHWyboFMcW6jc3WgRZN{[Xl? NUXWZZkzOTBizszN NVH4[IRZOjRiaB?= M1XP[GROW09? MljrTY5pcWKrdHnvckBw\iCKRFHDNUBie3Onc4Pl[EBieyCrbnT1Z5Rqd25ib3[gbIl{fG:wZTDIN{Bi[2W2eXzheIlwdiC5aYToJGlEPTBib3[gNk4zKM7:TR?= MknTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB2NUGzO|goRjJyNEWxN|c5RC:jPh?=
SCC4 MWnLbY5ie2ViQYPzZZk> MXOxJO69VQ>? Mlq5NlRp NVTJZW5LUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJJR2[nWuaX6gZYNmfHmuYYTpc44> NFywc409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MES1NlIzPSd-MkC0OVIzOjV:L3G+
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NB4 MVvGeY5kfGmxbjDBd5NigQ>? MVe1JO69VQ>? MV2yOEBp NXnydIpOTE2VTx?= MWXD[YxtKGO7Y3zlJIFzemW|dDDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCjY3P1cZVt[XSrb36gZZQheHKnLVexJJBp[XOn NYizeFJVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC0PVE1PDBpPkKwOFkyPDRyPD;hQi=>
NB4 Mn;mT4lv[XOnIFHzd4F6 MWO1JO69VQ>? M{L3UVI1KGh? MnPESG1UVw>? NUHIfId7UW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIFk\XS7bHH0[UB1fWK3bHnuJIxmfmWu NVHYPGR5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC0PVE1PDBpPkKwOFkyPDRyPD;hQi=>
NB4 NWHYNHBVTnWwY4Tpc44hSXO|YYm= MVi1JO69VQ>? M3zmbFI1KGh? NFHkdpZFVVOR M1rwWGlv\HWldHnvckBw\iCyMkHXRWYyN0OLUEGg[ZhxemW|c3nvci=> NH;MeHI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MES5NVQ1OCd-MkC0PVE1PDB:L3G+
NB4 NE\ZNWRMcW6jc3WgRZN{[Xl? MlroOUDPxE1? MlzDNlQhcA>? MmnYSG1UVw>? MnfWTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSEOgZYNmfHmuYYTpc44> MojqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB2OUG0OFAoRjJyNEmxOFQxRC:jPh?=
NUGC3 NH3zbW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjRNWE4T0l3ME2yMlk1KM7:TR?= MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODh3MEm3NUc,OjB6NUC5O|E9N2F-
A549 M2ntUWZ2dmO2aX;uJGF{e2G7 MYS1JO69VQ>? NX75cYkxOyCq M4S3VWROW09? MWXJcoR2[3Srb36gc4Yh[XW2b4DoZYd6KGmwIHj1cYFvKEF3NEmgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hVEN|SVm= MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODh3NUKwPEc,OjB6NUWyNFg9N2F-
HUT78 NHjVfZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTVO|IhcA>? NGjFc3hFVVOR M1excGdKPTB;MD6zJO69VQ>? M37ocFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOEi0NlA5Lz5{MEi4OFIxQDxxYU6=
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A431 MXfDfZRwfG:6aXOgRZN{[Xl? NYrO[WpGPzJiaB?= M1nNZmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE1OzFiY3XscJMhd3[ncnX4dJJme3OrbnegSWdHWiC5aYToJGlEPTBib3[gOE4zKM7:TR?= MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB6ME[yPUc,OjFyOEC2Nlk9N2F-
A549 NUOxNGRrS3m2b4TvfIlkKEG|c3H5 NWfIbmpLPzJiaB?= MlexR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{BwfmW{ZYjwdoV{e2mwZzDISGFEKHerdHigTWM2OCCxZjCxMlgh|ryP M2nvUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMEiwOlI6Lz5{MUC4NFYzQTxxYU6=
CAL27 MUXDfZRwfG:6aXOgRZN{[Xl? MVy3NkBp MnLPR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR2FNOjdiY3XscJMhd3[ncnX4dJJme3OrbnegSWdHWiC5aYToJGlEPTBib3[gN{4zKM7:TR?= NU\qRmE2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGwPFA3OjlpPkKxNFgxPjJ7PD;hQi=>
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Sf21 M1LwW2tqdmG|ZTDBd5NigQ>? M1PkOFMhcA>? M3rNd2lvcGmkaYTpc44hd2ZiRnzh[{B1[WepZXSgbJVu[W5icnXjc41jcW6jboSgTGRCSzhiZYjwdoV{e2WmIIfpeIghUUN3MDDv[kAyNjJizszN NUnhVYhmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGwPFA3OjlpPkKxNFgxPjJ7PD;hQi=>
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COR-L23 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\JdFVLOTBizszN NGDxbWg4OiCq MYfEUXNQ M1HWRmdKPTB;MT6xJO69VQ>? MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB6ME[0O{c,OjFyOEC2OFc9N2F-
DU145 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInrc5YyOCEQvF2= NVXHbYVXPzJiaB?= MX;EUXNQ MmXHS2k2OD1zLkC1JO69VQ>? M1G5fFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMEiwOlQ4Lz5{MUC4NFY1PzxxYU6=
LoVo NUjub|NyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDyNVAh|ryP M3rTdVczKGh? NV\SUpNwTE2VTx?= M{C2V2dKPTB;MT63JO69VQ>? MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB6ME[0O{c,OjFyOEC2OFc9N2F-
MCR5-SV2 Mn75S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILabmsyOCEQvF2= NU\hXnBiPzJiaB?= NYjwT|RmTE2VTx?= MWPHTVUxRTJwMTFOwG0> NEWwZZA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUC4NFY1Pyd-MkGwPFA3PDd:L3G+
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HCT116 NULYWIpOU2mwYYPlJGF{e2G7 MVGzNEDPxE1? MX:zNEBp MVvEUXNQ MojMTY5pcWKrdHnvckBw\iCKRFHDNUBie3Onc4Pl[EBieyCrbnT1Z5Rqd25ib3[gbIl{fG:wZTDIN2s6KGGlZYT5cIF1cW:w NGLaOVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUC4NFY1Pyd-MkGwPFA3PDd:L3G+
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CFBE41o NUfFcY1lU2mwYYPlJGF{e2G7 M{nyTlUh|ryP NXHHVXpFTE2VTx?= MmfKSI94diC{ZXf1cIF1cW:wIH;mJGhFSUN5IHH0JFAvOiC2bzC1JJVO NH\qNGM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm4OFk2QCd-MkG5PFQ6PTh:L3G+
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Hep3B M3TqUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWW0PEBp M3[xOGROW09? NGrvZXZIUTVyPUCuOlkh|ryP MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR|OUi2N{c,OjJ2M{m4OlM9N2F-
BE(2)-C MoPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV23NkBp MXLEUXNQ M4PEfGlEPzB;MjFOwG0> NXLaZZhjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK5N|I{OTZpPkKyPVMzOzF4PD;hQi=>
Bel7402 M4rE[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfIO|IhcA>? MU\EUXNQ NEnnWZpIUTlyPUG3JO69VQ>? NX7RdXdCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwOlE{PzZpPkKzNFYyOzd4PD;hQi=>
Bel7404 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XrdlczKGh? M1Hq[mROW09? NIjGOYVIUTlyPUG4JO69VQ>? M17qRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|ME[xN|c3Lz5{M{C2NVM4PjxxYU6=
BGC823 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYG3NkBp NIjNVmNFVVOR M{TheGdKQTB;Nz61JO69VQ>? NVu5NYdvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwOlE{PzZpPkKzNFYyOzd4PD;hQi=>
MGC803 MkXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVy3NkBp M{nOZ2ROW09? NIXrWmhIUTlyPUGwMlgh|ryP MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB4MUO3Okc,OjNyNkGzO|Y9N2F-
SGC7901 M3HLdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlT0O|IhcA>? MXjEUXNQ NEXVeZhIUTlyPUmuOEDPxE1? MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB4MUO3Okc,OjNyNkGzO|Y9N2F-
SKHEP1 NVjT[WgxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY[3NkBp NF7SRXVFVVOR NH3jdphIUTlyPUG3JO69VQ>? MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB4MUO3Okc,OjNyNkGzO|Y9N2F-
SMMC7721 M3mwR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVm3NkBp NGXuUY9FVVOR MYDHTVkxRTJyIN88US=> NEjRfmw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{C2NVM4Pid-MkOwOlE{PzZ:L3G+
NUGC3 M1qyXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPZNVAh|ryP MVPHTV0zNjl2IN88US=> MoPSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNzNkOzN|IoRjJ|MU[zN|MzRC:jPh?=
A2780 CisR MYTLbY5ie2ViQYPzZZk> MXuxPEBp MX3Jcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNESg{txO M4nFWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MkWyOlA{Lz5{M{K1NlYxOzxxYU6=
CAL27 sens MmfsT4lv[XOnIFHzd4F6 M1XnO|E5KGh? MoeyTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkO2JO69VQ>? NWexTmZIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyOVI3ODNpPkKzNlUzPjB|PD;hQi=>
CAL27 CisR MlvwT4lv[XOnIFHzd4F6 Ml73NVghcA>? NXvjV4htUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlYyKM7:TR?= Mnv6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{NUK2NFMoRjJ|MkWyOlA{RC:jPh?=
KYSE-510 CisR M2H6bGtqdmG|ZTDBd5NigQ>? Mk\VNVghcA>? NUDJcJhmUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlU6KM7:TR?= Mlj4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{NUK2NFMoRjJ|MkWyOlA{RC:jPh?=
KYSE-510 sens NVP6fWdwU2mwYYPlJGF{e2G7 NVu4[WV5OThiaB?= NVT6RpBiUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlch|ryP MnTXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{NUK2NFMoRjJ|MkWyOlA{RC:jPh?=
MDA-MB-231 sens NX7LOZBEU2mwYYPlJGF{e2G7 NXPhTYhWOThiaB?= NI\jdGtKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOlEh|ryP NX65UolURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyOVI3ODNpPkKzNlUzPjB|PD;hQi=>
MDA-MB-231 CisR MnLXT4lv[XOnIFHzd4F6 MnjiNVghcA>? NU\5Nnk4UW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlYyKM7:TR?= MmnXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{NUK2NFMoRjJ|MkWyOlA{RC:jPh?=
ES2 M3PSbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;xOWFMPDhiaB?= MoG4SG1UVw>? MVXJR|UxRTF{Lkeg{txO M4i5WlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NEmzOFQ6Lz5{M{S5N|Q1QTxxYU6=
MDA-MB-231 MlfYT4lv[XOnIFHzd4F6 MVGxNEDPxE1? MXSzNEBucW5? MUXEUXNQ NFTGPXZKdmirYnn0bY9vKG:oIFjERWMz[Q>? NWLsd5UzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0PVM1PDlpPkKzOFk{PDR7PD;hQi=>
MDA-MB-231 MUfLbY5ie2ViQYPzZZk> NWfV[VFEOSEQvF2= M1\zU|I1KGh? MmK2SG1UVw>? MnvaTY5pcWKrdHnvckBw\iCKRFHDOkBie3Onc4Pl[EBieyCjY3X0fYxifGmxbjDs[ZZmdHNib3[geJVjfWyrbh?= NEfISXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S5N|Q1QSd-MkO0PVM1PDl:L3G+
HS68 MYrDfZRwfG:6aXOgRZN{[Xl? MojyNVAh|ryP MX63NkBp MWPEUXNQ NX3oVIsyUUN3ME20MlYh|ryP MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzV5MEW0Nkc,OjN3N{C1OFI9N2F-
MEF MoT0R5l1d3SxeHnjJGF{e2G7 M{TGdFExKM7:TR?= MXy3NkBp MV;EUXNQ MWfJR|UxRTRwNDFOwG0> NWPhU|h[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1O|A2PDJpPkKzOVcxPTR{PD;hQi=>
BGC823 MnL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jaUWROW09? NUi3SpFLT0l3ME2zMlA6KM7:TR?= NF7HbpQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[wNVcxPid-MkO2NFE4ODZ:L3G+
High5 M1zzZWtqdmG|ZTDBd5NigQ>? MUGyOEBp M2HwPWlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiSFTBR|Yhf2m2aDDJR|UxKG:oIECuNFkh|ryP MkLSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MEK1NlMoRjJ|NkCyOVI{RC:jPh?=
High5 MmPNT4lv[XOnIFHzd4F6 MYCyOEBp NW[wd2dbUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDISGFEOSC5aYToJGlEPTBib3[gNE4yOiEQvF2= M3L5eFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkCyOVI{Lz5{M{[wNlUzOzxxYU6=
High5 M{H1dmtqdmG|ZTDBd5NigQ>? MXWyOEBp NGDXfXNKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjERWM{KHerdHigTWM2OCCxZjCwMlE4KM7:TR?= NF;TRlk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[wNlUzOyd-MkO2NFI2OjN:L3G+
A549 M2TvNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLndnRZTE2VTx?= NWnIV3dQUUN3ME2xMlA4QSEQvF2= MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ2NEKxNEc,OjN4NESyNVA9N2F-
HCT116 MnvFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjNVVhFVVOR M4DFVWlEPTB;MD63OVch|ryP NUjNT41GRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2OFQzOTBpPkKzOlQ1OjFyPD;hQi=>
K562 NWL0[4lKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zId2ROW09? NETRT2FKSzVyPUCuOlQ2KM7:TR?= NYXyPGFbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2OFQzOTBpPkKzOlQ1OjFyPD;hQi=>
GBC-SD NVnGN|h[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4GwZVUh|ryP NWPNWXJzPzJiaB?= NUToUFM6TE2VTx?= NFrZboJKSzVyPUG0Mlgh|ryP NVOxb4FNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO3NFczPjBpPkKzO|A4OjZyPD;hQi=>
HGC27 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrUOUDPxE1? MWK3NkBp M{[0VWROW09? MlTiTWM2OD13LkSg{txO NGHJSoM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{ewO|I3OCd-MkO3NFczPjB:L3G+
HL60 NInCfWpMcW6jc3WgRZN{[Xl? NYjhSmlMPSEQvF2= M1O2TFI1KGh? NWXubmZJTE2VTx?= MV\Jcohq[mm2aX;uJI9nKEiGQVO= MmrwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5MEeyOlAoRjJ|N{C3NlYxRC:jPh?=
Vero NVjZOYJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPj[FBrPzJiaB?= Ml3qSG1UVw>? NFX5SJNKSzVyPUCuPUDPxE1? MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd6NkS1Nkc,OjN5OE[0OVI9N2F-
NCI60 M4HYW2N6fG:2b4jpZ{BCe3OjeR?= MVq0PEBp NFXhN5dFVVOR M{jjRWdKRTBwNUOg{txO NFLpW5A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NECxOVMzPyd-MkSwNVU{Ojd:L3G+
SW620 NWfwUWxkS3m2b4TvfIlkKEG|c3H5 NG\BO|E1QCCq M{XERmROW09? NUD2dYhpT0l;MD61OEDPxE1? MmroQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyMUWzNlcoRjJ2MEG1N|I4RC:jPh?=
U251 MW\DfZRwfG:6aXOgRZN{[Xl? M3m0NlQ5KGh? MmHhSG1UVw>? M{HUeGdKRTFwNUOg{txO NGHqOVc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NECxOVMzPyd-MkSwNVU{Ojd:L3G+
KM12 NXzVTXJ2S3m2b4TvfIlkKEG|c3H5 MkTPOFghcA>? Mnv3SG1UVw>? NGjmNWxIUT1zLki4JO69VQ>? M3zDcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEG1N|I4Lz5{NECxOVMzPzxxYU6=
Hs578T NGXzXlREgXSxdH;4bYMhSXO|YYm= MUi0PEBp NEPEUWFFVVOR NVnPRWlxT0l;ND64N{DPxE1? NYjYcWNSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwNVU{OjdpPkK0NFE2OzJ5PD;hQi=>
MDA-MB-231 NEGx[4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\qOFghcA>? MYnJR|UxRTBwMU[g{txO MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB7NUCxOkc,OjRyOUWwNVY9N2F-
MCF7 M3z0cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV60PEBp MULHTV0xNjR3IN88US=> M1r2OVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUG5OVU2Lz5{NEGxPVU2PTxxYU6=
MDA-MB-435 NETVTWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4qwTVQ5KGh? M1Xz[WdKRTBwOEig{txO NVPoXHhQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSxNVk2PTVpPkK0NVE6PTV3PD;hQi=>
AsPC1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjYd|dSOzBizszN NF\V[2U1QCCq NYrEOWhLTE2VTx?= MmXkTWM2OD1|Lk[2JO69VQ>? M1HLR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUi1N|c5Lz5{NEG4OVM4QDxxYU6=
Jurkat E6.1 M4jOSWtqdmG|ZTDBd5NigQ>? MWiyJIg> NI[4TGtFVVOR NVfZbIM1UW6qaXLpeIlwdiCxZjDISGFEPCC5aYToJGlEPTBib3[gNE4xPCEQvF2= NV3Pd|NrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyOlE5PjJpPkK0NlYyQDZ{PD;hQi=>
KG1 MoTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\jOFghcA>? M3fUW2lEPTB;MT6xOUDPxE1? Mmm1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MkWwNFMoRjJ2NUK1NFA{RC:jPh?=
HEL MmnLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXQfGZJPDhiaB?= NHrnSJJFVVOR Ml;ITWM2OD1yLkS5JO69VQ>? MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ7NEC1OUc,OjR4OUSwOVU9N2F-
HSC3 MkDHR5l1d3SxeHnjJGF{e2G7 MUOxNkBp NULE[W5lTE2VTx?= MnT6TWM2OD1yLkexJO69VQ>? MkTxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5Nk[1OlAoRjJ2N{[2OVYxRC:jPh?=
HT-29 M4jkZWN6fG:2b4jpZ{BCe3OjeR?= MWSxNkBp Ml\JSG1UVw>? MVrJR|UxRTBwN{Kg{txO MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd4NkW2NEc,OjR5Nk[1OlA9N2F-
KB MmPOR5l1d3SxeHnjJGF{e2G7 MUWxNkBp M3vxRWROW09? NWTlXlA4UUN3ME2wMlc2KM7:TR?= NFXtZmY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEe2OlU3OCd-MkS3OlY2PjB:L3G+
H460 MVfDfZRwfG:6aXOgRZN{[Xl? M3;NRVEzKGh? NWfadINpTE2VTx?= Ml;WTWM2OD1yLkiyJO69VQ>? NVT3WnlFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3OlY2PjBpPkK0O|Y3PTZyPD;hQi=>
MONE1 MWLDfZRwfG:6aXOgRZN{[Xl? NF7pb5IyOiCq MUPEUXNQ M1fTdGlEPTB;MT6xPEDPxE1? NY\0dWl[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3OlY2PjBpPkK0O|Y3PTZyPD;hQi=>
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