Gemcitabine HCl
别名: NSC 613327 HCl,LY-188011 HCl 中文名称：盐酸吉西他滨
Gemcitabine HCl是一种DNA synthesis抑制剂，作用于PANC1，MIAPaCa2，BxPC3和Capan2细胞，IC50分别为50 nM， 40 nM， 18 nM和12 nM。
Gemcitabine HCl Chemical Structure
CAS: 122111-03-9
客户使用Selleck的Gemcitabine HCl发表文献178篇
产品质控
批次：
纯度：
99.96%
99.96
Gemcitabine HCl相关产品
相关信号通路图
DNA/RNA Synthesis抑制剂选择性比较
细胞实验数据示例
| 细胞系 | 实验类型 | 给药浓度 | 孵育时间 | 活性描述 | 文献信息 |
|---|---|---|---|---|---|
| CCRF-CEM | Growth Inhibition Assay | 72 h | IC50=2.0 ± 0.6 nM | 21851843 | |
| Ramos | Cytotoxicity assay | 72 hrs | EC50 = 0.00003 μM | 27032331 | |
| BV173 | Cytotoxicity assay | 3 days | IC50 = 0.001 μM | 21711054 | |
| NCI-H23 | Cytotoxicity assay | 5 days | GI50 = 0.002 μM | 19929004 | |
| OVCAR8 | Antiproliferative assay | 72 hrs | IC50 = 0.0026 μM | 18469809 | |
| PC3 | Antiproliferative assay | 72 hrs | IC50 = 0.0026 μM | 18469809 | |
| A2780/E6 | Antiproliferative assay | 72 hrs | IC50 = 0.0026 μM | 18469809 | |
| HCT15 | Cytotoxicity assay | 5 days | GI50 = 0.003 μM | 19929004 | |
| OVCAR8 | Antiproliferative assay | 72 hrs | IC50 = 0.003 μM | 20873740 | |
| C3 | Antiproliferative assay | 72 hrs | IC50 = 0.003 μM | 20873740 | |
| BxPC3 | Growth inhibition assay | 48 hrs | GI50 = 0.00364 μM | 23094992 | |
| A549 | Cytotoxicity assay | 24 hrs | IC50 = 0.0039 μM | 25874330 | |
| A549 | Cytotoxicity assay | 48 hrs | IC50 = 0.0039 μM | 25874330 | |
| MRC5 | Cytotoxicity assay | 48 hrs | IC50 = 0.0039 μM | 25874330 | |
| T24 | Cytotoxicity assay | 48 hrs | IC50 = 0.0039 μM | 25874330 | |
| T24 | Cytotoxicity assay | 24 hrs | IC50 = 0.0039 μM | 25874330 | |
| MRC5 | Cytotoxicity assay | 24 hrs | IC50 = 0.0039 μM | 25874330 | |
| BT549 | Cytotoxicity assay | 5 days | GI50 = 0.004 μM | 19929004 | |
| MCF7 | Cytotoxicity assay | 24 hrs | LD50 = 0.004 μM | 24786915 | |
| MES-SA | Cytotoxicity assay | 3 days | IC50 = 0.005 μM | 21711054 | |
| HCT116 | Cytotoxicity assay | 24 hrs | LD50 = 0.005 μM | 24786915 | |
| RAW264.7 | Cytotoxicity assay | 24 hrs | LD50 = 0.005 μM | 24786915 | |
| PC3 | Cytotoxicity assay | 5 days | GI50 = 0.006 μM | 19929004 | |
| HCT116 | Antiproliferative assay | 72 hrs | IC50 = 0.006 μM | 20873740 | |
| K562 | Cytotoxicity assay | 3 days | IC50 = 0.006 μM | 21711054 | |
| CT26 | Cytotoxicity assay | 3 days | IC50 = 0.006 μM | 21711054 | |
| BxPC3 | Growth inhibition assay | 96 hrs | IC50 = 0.006 μM | 29356532 | |
| MRC5 | Cytotoxicity assay | 48 hrs | IC50 = 0.0063 μM | 25874330 | |
| A549 | Cytotoxicity assay | 48 hrs | IC50 = 0.0068 μM | 25874330 | |
| MRC5 | Cytotoxicity assay | 24 hrs | IC50 = 0.0068 μM | 25874330 | |
| T24 | Cytotoxicity assay | 48 hrs | IC50 = 0.0069 μM | 25874330 | |
| EL4 | Cytotoxicity assay | 3 days | IC50 = 0.007 μM | 21711054 | |
| L1210 | Cytotoxicity assay | 3 days | IC50 = 0.007 μM | 21711054 | |
| MCF7 | Cytotoxicity assay | 2 days | IC50 = 0.0072 μM | 24341356 | |
| BT549 | Cytotoxicity assay | 3 days | IC50 = 0.008 μM | 21711054 | |
| MOLT4 | Cytotoxicity assay | 24 hrs | LD50 = 0.008 μM | 24786915 | |
| BxPC3 | Growth inhibition assay | 48 hrs | LC50 = 0.00871 μM | 23094992 | |
| DMS53 | Antiproliferative assay | 72 hrs | IC50 = 0.009 μM | 22861499 | |
| HCT116 | Antiproliferative assay | 72 hrs | IC50 = 0.0097 μM | 18469809 | |
| HCT15 | Antiproliferative assay | 72 hrs | IC50 = 0.0099 μM | 18469809 | |
| HeLa | Cytotoxicity assay | 4 days | IC50 = 0.0099 μM | 24341356 | |
| MCF7 | Antitumor assay | 48 hrs | GI50 = 0.01 μM | 18588281 | |
| SF268 | Antiproliferative assay | 72 hrs | IC50 = 0.01 μM | 20873740 | |
| HCT15 | Antiproliferative assay | 72 hrs | IC50 = 0.01 μM | 20873740 | |
| BxPC3 | Cytotoxicity assay | 5 days | EC50 = 0.01 μM | 24867590 | |
| SF268 | Antiproliferative assay | 72 hrs | IC50 = 0.0103 μM | 18469809 | |
| Jurkat | Cytotoxicity assay | 24 hrs | LD50 = 0.012 μM | 24786915 | |
| L1210 | Cytotoxicity assay | 2 days | IC50 = 0.013 μM | 24341356 | |
| L1210 | Cytotoxicity assay | 48 hrs | IC50 = 0.013 μM | 24471998 | |
| SW480 | Antiproliferative assay | 72 hrs | IC50 = 0.0136 μM | 18469809 | |
| A2780 | Antiproliferative assay | 72 hrs | IC50 = 0.0166 μM | 18469809 | |
| T24 | Cytotoxicity assay | 24 hrs | IC50 = 0.017 μM | 25874330 | |
| T24 | Cytotoxicity assay | 24 hrs | IC50 = 0.018 μM | 25874330 | |
| P388D1 | Cytotoxicity assay | 3 days | IC50 = 0.019 μM | 21711054 | |
| Capan1 | Growth inhibition assay | 96 hrs | IC50 = 0.019 μM | 29356532 | |
| SF539 | Antiproliferative assay | 72 hrs | IC50 = 0.0198 μM | 18469809 | |
| SF539 | Antiproliferative assay | 72 hrs | IC50 = 0.02 μM | 20873740 | |
| A549 | Antiproliferative assay | 72 hrs | IC50 = 0.02 μM | 22861499 | |
| CCRF-CEM | Cytotoxicity assay | 72 hrs | IC50 = 0.02 μM | 28221790 | |
| MRC5 | Cytotoxicity assay | 24 hrs | IC50 = 0.0216 μM | 25874330 | |
| CEM-DNR-bulk | Cytotoxicity assay | 3 days | IC50 = 0.022 μM | 21711054 | |
| Jurkat | Cytotoxicity assay | 72 hrs | EC50 = 0.023 μM | 27032331 | |
| HeLa | Cytotoxicity assay | 24 hrs | LD50 = 0.023 μM | 24786915 | |
| MDA-MB-231 | Antiproliferative assay | 48 hrs | IC50 = 0.025 μM | 25350923 | |
| U373-MAGI | Antiviral assay | 2 hrs | EC50 = 0.0275 μM | 24120088 | |
| A549 | Cytotoxicity assay | 24 hrs | IC50 = 0.029 μM | 25874330 | |
| HT29 | Antitumor assay | 48 hrs | GI50 = 0.03 μM | 18588281 | |
| Jurkat | Antiproliferative assay | 72 hrs | IC50 = 0.03 μM | 20873740 | |
| HCT116 | Cytotoxicity assay | 72 hrs | IC50 = 0.03 μM | 28221790 | |
| MDA-MB-231 | Growth inhibition assay | 72 hrs | IC50 = 0.03 μM | 29253340 | |
| HCT116 | Growth inhibition assay | 72 hrs | IC50 = 0.03 μM | 29253340 | |
| A2780 | Antiproliferative assay | 72 hrs | IC50 = 0.035 μM | 20873740 | |
| MIAPaCa2 | Growth inhibition assay | 48 hrs | GI50 = 0.03583 μM | 23094992 | |
| MDA-MB-231 | Antiproliferative assay | 48 hrs | IC50 = 0.0364 μM | 29795767 | |
| Jurkat | Antiproliferative assay | 72 hrs | IC50 = 0.0453 μM | 18469809 | |
| HeLa | Cytotoxicity assay | 72 hrs | IC50 = 0.05 μM | 22944119 | |
| K562 | Cytotoxicity assay | 48 hrs | IC50 = 0.05 μM | 24631359 | |
| A549 | Cytotoxicity assay | 72 hrs | IC50 = 0.05 μM | 28221790 | |
| K562-TAX | Cytotoxicity assay | 72 hrs | IC50 = 0.05 μM | 28221790 | |
| COLO205 | Antiproliferative assay | 72 hrs | IC50 = 0.0514 μM | 18469809 | |
| MCF7 | Cytotoxicity assay | 72 hrs | IC50 = 0.06 μM | 22944119 | |
| MIAPaCa2 | Cytotoxicity assay | 72 hrs | IC50 = 0.06 μM | 22944119 | |
| PC3 | Cytotoxicity assay | 72 hrs | EC50 = 0.065 μM | 27032331 | |
| CEM | Cytotoxicity assay | 3 days | IC50 = 0.069 μM | 24341356 | |
| HPAC | Cytotoxicity assay | 3 days | IC50 = 0.073 μM | 21711054 | |
| MCF7 | Antiproliferative assay | 72 hrs | IC50 = 0.08 μM | 20873740 | |
| MCF7 | Antiproliferative assay | 72 hrs | IC50 = 0.0803 μM | 18469809 | |
| CEM | Cytotoxicity assay | 72 hrs | IC50 = 0.086 μM | 24471998 | |
| U2OS | Antiproliferative assay | 72 hrs | IC50 = 0.0907 μM | 18469809 | |
| K562 | Cytotoxicity assay | 72 hrs | IC50 = 0.1 μM | 28221790 | |
| CEM-DNR-bulk | Cytotoxicity assay | 72 hrs | IC50 = 0.1 μM | 28221790 | |
| MIAPaCa2 | Growth inhibition assay | 48 hrs | LC50 = 0.1 μM | 23094992 | |
| PANC1 | Cytotoxicity assay | 48 hrs | IC50 = 0.11 μM | 22342146 | |
| MIAPaCa2 | Cytotoxicity assay | 72 hrs | IC50 = 0.11 μM | 29328656 | |
| MIAPaCa2 | Antiproliferative assay | 70 hrs | IC50 = 0.12 μM | 29471119 | |
| MCF7 | Cytotoxicity assay | 3 days | IC50 = 0.149 μM | 21711054 | |
| MCF7 | Cytotoxicity assay | 72 hrs | IC50 = 0.15 μM | 26025875 | |
| CaCo2 | Antitumor assay | 48 hrs | GI50 = 0.18 μM | 18588281 | |
| U2OS | Antiproliferative assay | 72 hrs | IC50 = 0.18 μM | 20873740 | |
| U2OS | Cytotoxicity assay | 72 hrs | IC50 = 0.18 μM | 28221790 | |
| MDA-MB-231 | Cytotoxicity assay | 24 hrs | IC50 = 0.19 μM | 25703296 | |
| NCI-H460 | Cytotoxicity assay | 48 hrs | IC50 = 0.23 μM | 22342146 | |
| MDA-MB-231 | Cytotoxicity assay | 3 days | IC50 = 0.245 μM | 21711054 | |
| A2780 | Cytotoxicity assay | 72 hrs | IC50 = 0.31 μM | 19362474 | |
| K562 | Antitumor assay | 48 hrs | GI50 = 0.32 μM | 18588281 | |
| HCT116 | Cytotoxicity assay | 48 hrs | IC50 = 0.32 μM | 22342146 | |
| CFPAC-1 | Cytotoxicity assay | 96 hrs | IC50 = 0.35 μM | 24631359 | |
| PANC1 | Cytotoxicity assay | 72 hrs | IC50 = 0.4 μM | 29656202 | |
| HCT116 | Cytotoxicity assay | 72 hrs | IC50 = 0.41 μM | 28221790 | |
| CFPAC-1 | Cytotoxicity assay | 72 hrs | IC50 = 0.47 μM | 24631359 | |
| ACHN | Cytotoxicity assay | 48 hrs | IC50 = 0.48 μM | 22342146 | |
| HCT116-E6 | Antiproliferative assay | 72 hrs | IC50 = 0.5 μM | 20873740 | |
| C6 | Cytotoxicity assay | 3 days | IC50 = 0.504 μM | 21711054 | |
| LNCAP | Cytotoxicity assay | 3 days | IC50 = 0.512 μM | 21711054 | |
| Calu1 | Cytotoxicity assay | 48 hrs | IC50 = 0.52 μM | 22342146 | |
| HT-29 | Cytotoxicity assay | 72 hrs | IC50 = 0.52 μM | 26025875 | |
| MCF7 | Cytotoxicity assay | 72 hrs | IC50 = 0.57 μM | 28075592 | |
| K562 | Antiproliferative assay | 72 hrs | IC50 = 0.6 μM | 20873740 | |
| MIAPaCa2 | Cytotoxicity assay | 24 hrs | IC50 = 0.6 μM | 25703296 | |
| MDA-MB-231 | Cytotoxicity assay | 72 hrs | IC50 = 0.65 μM | 26025875 | |
| BxPC3 | Cytotoxicity assay | 72 hrs | IC50 = 0.67 μM | 24471998 | |
| K562 | Cytotoxicity assay | 3 days | IC50 = 0.718 μM | 21711054 | |
| K562 | Antiproliferative assay | 72 hrs | IC50 = 0.7459 μM | 18469809 | |
| Bel7402 | Cytotoxicity assay | 72 hrs | IC50 = 0.84 μM | 19362474 | |
| HCT116/E6 | Antiproliferative assay | 72 hrs | IC50 = 0.8965 μM | 18469809 | |
| HeLa | Cytotoxicity assay | 96 hrs | IC50 = 0.9 μM | 24631359 | |
| HB-1 | Antiviral assay | 24 hrs | EC50 = 1 μM | 20580554 | |
| MIAPaCa2 | Cytotoxicity assay | 72 hrs | IC50 = 1.04 μM | 24471998 | |
| SK-N-AS | Cytotoxicity assay | 3 days | IC50 = 1.1 μM | 21711054 | |
| SW1990 | Cytotoxicity assay | 72 hrs | IC50 = 1.2 μM | 19362474 | |
| A549 | Cytotoxicity assay | 72 hrs | IC50 = 1.4 μM | 19362474 | |
| U87MG | Cytotoxicity assay | 3 days | IC50 = 1.49 μM | 21711054 | |
| HT-29 | Cytotoxicity assay | 3 days | IC50 = 1.53 μM | 21711054 | |
| Capan2 | Cytotoxicity assay | 72 hrs | IC50 = 1.7 μM | 19362474 | |
| SW480 | Antiproliferative assay | 72 hrs | IC50 = 1.7 μM | 20873740 | |
| PANC1 | Cytotoxicity assay | 72 hrs | IC50 = 1.7 μM | 29656202 | |
| HCT8 | Cytotoxicity assay | 72 hrs | IC50 = 1.74 μM | 19362474 | |
| HT-29 | Cytotoxicity assay | 48 hrs | IC50 = 1.95 μM | 23968824 | |
| MIAPaCa2 | Cytotoxicity assay | 5 days | EC50 = 2 μM | 24867590 | |
| BL21(DE3) | Function assay | 1 min | Km = 2.15 μM | 23230131 | |
| SW1990 | Cytotoxicity assay | 48 hrs | IC50 = 2.3 μM | 27966950 | |
| NCI-H146 | Cytotoxicity assay | 3 days | IC50 = 2.78 μM | 21711054 | |
| BxPC3 | Cytotoxicity assay | 72 hrs | IC50 = 2.9 μM | 19362474 | |
| p53 deficient COLO205 | Antiproliferative assay | 72 hrs | IC50 = 3 μM | 20873740 | |
| MiaPaCa | Cytotoxicity assay | 6 days | IC50 = 3 μM | 23360104 | |
| COLO205 | Cytotoxicity assay | 48 hrs | IC50 = 3.24 μM | 23968824 | |
| MCF7 | Cytotoxicity assay | 72 hrs | IC50 = 3.28 μM | 19362474 | |
| MIAPaCa2 | Cytotoxicity assay | 72 hrs | IC50 = 3.3 μM | 29328656 | |
| HeLa | Cytotoxicity assay | 24 hrs | IC50 = 3.3 μM | 25703296 | |
| FTC-133 | Cytotoxicity assay | 24 hrs | IC50 = 3.36 μM | 24436994 | |
| BxPC3 | Growth inhibition assay | 48 hrs | GI50 = 3.64 μM | 22512908 | |
| COLO320DM | Cytotoxicity assay | 48 hrs | IC50 = 3.92 μM | 23968824 | |
| HeLa | Cytotoxicity assay | 3 days | IC50 = 4.12 μM | 21711054 | |
| 8305C | Cytotoxicity assay | 24 hrs | IC50 = 4.53 μM | 24436994 | |
| PANC1 | Cytotoxicity assay | 72 hrs | IC50 = 5.6 μM | 19362474 | |
| PANC1 | Growth inhibition assay | 72 hrs | GI50 = 5.8 μM | 28495081 | |
| SK-MEL-2 | Cytotoxicity assay | 3 days | IC50 = 7.11 μM | 21711054 | |
| CEM | Cytotoxicity assay | 3 days | IC50 = 7.6 μM | 24341356 | |
| SW1573 | Cytotoxicity assay | 72 hrs | IC50 = 8.3 μM | 17419604 | |
| BxPC3 | Growth inhibition assay | 48 hrs | LC50 = 8.71 μM | 22512908 | |
| MCF7 | Cytotoxicity assay | 72 hrs | IC50 = 8.9 μM | 28075592 | |
| BJ | Cytotoxicity assay | 3 days | IC50 = 9.88 μM | 21711054 | |
| HeLa | Cytotoxicity assay | 72 hrs | IC50 = 10 μM | 24631359 | |
| B16-F10-Luc-G5 | Antiproliferative assay | 24 hrs | IC50 = 11 μM | 27349332 | |
| A549 | Cytotoxicity assay | 72 hrs | IC50 = 13.1 μM | 17419604 | |
| MiaPaCa | Cytotoxicity assay | 72 hrs | IC50 = 17.1 μM | 23489626 | |
| BxPC3 | Antiproliferative assay | 72 hrs | IC50 = 20.2 μM | 28576633 | |
| CV1 | Cytotoxicity assay | 72 hrs | IC50 = 21.9 μM | 23489626 | |
| AsPC1 | Antiproliferative assay | 72 hrs | IC50 = 26.8 μM | 28576633 | |
| PANC1 | Antiproliferative assay | 72 hrs | IC50 = 30.4 μM | 28576633 | |
| MIAPaCa2 | Growth inhibition assay | 48 hrs | GI50 = 35.83 μM | 22512908 | |
| TC-1 | Growth Inhibition Assay | IC50=14.7 ± 2.8 nM | 22425885 | ||
| L1210 10K | Growth Inhibition Assay | IC50=22.2 ± 3.7 μM | 22425885 | ||
| L1210 wt | Growth Inhibition Assay | IC50=1.3 ± 0.3 nM | 22425885 | ||
| CCRF-CEM/dCK−/− | Growth Inhibition Assay | IC50=240.4 ± 29.0 μM | 22425885 | ||
| CCRF-CEM | Growth Inhibition Assay | IC50=2.9 ± 1.8 nM | 22425885 | ||
| TC-1-GR | Growth Inhibition Assay | IC50=36.7 ± 5.1 μM | 22425885 | ||
| MIA PaCa-2 | Growth Inhibition Assay | IC50=49.7 ± 17.7 nM | 22425885 | ||
| PANC-1 | Growth Inhibition Assay | IC50=> 400 μM | 22425885 | ||
| CCRF-CEM | Growth Inhibition Assay | IC50=2.9 ± 1.8 nM | 22425885 | ||
| CCRF-CEM-AraC-8C | Growth Inhibition Assay | IC50=998.8 ± 9.4 nM | 22425885 | ||
| MV-4-11 | Growth inhibition assay | IC50 = 0.0005 nM | SANGER | ||
| ES4 | Growth inhibition assay | IC50 = 0.0007 nM | SANGER | ||
| ACHN | Growth inhibition assay | IC50 = 0.0009 nM | SANGER | ||
| KYSE-510 | Growth inhibition assay | IC50 = 0.001 nM | SANGER | ||
| EW-7 | Growth inhibition assay | IC50 = 0.0026 nM | SANGER | ||
| BFTC-905 | Growth inhibition assay | IC50 = 0.0051 nM | SANGER | ||
| KE-37 | Growth inhibition assay | IC50 = 0.0056 nM | SANGER | ||
| SBC-5 | Growth inhibition assay | IC50 = 0.0057 nM | SANGER | ||
| NKM-1 | Growth inhibition assay | IC50 = 0.0071 nM | SANGER | ||
| RH-1 | Growth inhibition assay | IC50 = 0.0072 nM | SANGER | ||
| ALL-PO | Growth inhibition assay | IC50 = 0.0083 nM | SANGER | ||
| QIMR-WIL | Growth inhibition assay | IC50 = 0.0089 nM | SANGER | ||
| A375 | Growth inhibition assay | IC50 = 0.0099 nM | SANGER | ||
| SIG-M5 | Growth inhibition assay | IC50 = 0.0104 nM | SANGER | ||
| KGN | Growth inhibition assay | IC50 = 0.0108 nM | SANGER | ||
| EW-13 | Growth inhibition assay | IC50 = 0.0112 nM | SANGER | ||
| NCI-SNU-1 | Growth inhibition assay | IC50 = 0.016 nM | SANGER | ||
| PSN1 | Growth inhibition assay | IC50 = 0.0165 nM | SANGER | ||
| HUTU-80 | Growth inhibition assay | IC50 = 0.0166 nM | SANGER | ||
| 786-0 | Growth inhibition assay | IC50 = 0.023 nM | SANGER | ||
| EW-16 | Growth inhibition assay | IC50 = 0.023 nM | SANGER | ||
| ES1 | Growth inhibition assay | IC50 = 0.0268 nM | SANGER | ||
| RKO | Growth inhibition assay | IC50 = 0.0278 nM | SANGER | ||
| ESS-1 | Growth inhibition assay | IC50 = 0.0286 nM | SANGER | ||
| SK-UT-1 | Growth inhibition assay | IC50 = 0.0297 nM | SANGER | ||
| LB2241-RCC | Growth inhibition assay | IC50 = 0.0318 nM | SANGER | ||
| CHL-1 | Growth inhibition assay | IC50 = 0.0324 nM | SANGER | ||
| SW1783 | Growth inhibition assay | IC50 = 0.0336 nM | SANGER | ||
| MEL-JUSO | Growth inhibition assay | IC50 = 0.0391 nM | SANGER | ||
| HT-29 | Growth inhibition assay | IC50 = 0.0413 nM | SANGER | ||
| SNG-M | Growth inhibition assay | IC50 = 0.0425 nM | SANGER | ||
| TE-15 | Growth inhibition assay | IC50 = 0.0464 nM | SANGER | ||
| HOS | Growth inhibition assay | IC50 = 0.048 nM | SANGER | ||
| BB65-RCC | Growth inhibition assay | IC50 = 0.0512 nM | SANGER | ||
| HCE-4 | Growth inhibition assay | IC50 = 0.0528 nM | SANGER | ||
| MHH-ES-1 | Growth inhibition assay | IC50 = 0.0531 nM | SANGER | ||
| RPMI-7951 | Growth inhibition assay | IC50 = 0.0541 nM | SANGER | ||
| IST-SL2 | Growth inhibition assay | IC50 = 0.0584 nM | SANGER | ||
| CMK | Growth inhibition assay | IC50 = 0.0586 nM | SANGER | ||
| GR-ST | Growth inhibition assay | IC50 = 0.0595 nM | SANGER | ||
| NALM-6 | Growth inhibition assay | IC50 = 0.0622 nM | SANGER | ||
| RPMI-6666 | Growth inhibition assay | IC50 = 0.0652 nM | SANGER | ||
| LC-2-ad | Growth inhibition assay | IC50 = 0.0653 nM | SANGER | ||
| ARH-77 | Growth inhibition assay | IC50 = 0.0711 nM | SANGER | ||
| IST-MEL1 | Growth inhibition assay | IC50 = 0.0726 nM | SANGER | ||
| SW1710 | Growth inhibition assay | IC50 = 0.0751 nM | SANGER | ||
| DEL | Growth inhibition assay | IC50 = 0.0887 nM | SANGER | ||
| AGS | Growth inhibition assay | IC50 = 0.0902 nM | SANGER | ||
| NCI-H2122 | Growth inhibition assay | IC50 = 0.0945 nM | SANGER | ||
| HSC-4 | Growth inhibition assay | IC50 = 0.1022 nM | SANGER | ||
| AM-38 | Growth inhibition assay | IC50 = 0.1215 nM | SANGER | ||
| 769-P | Growth inhibition assay | IC50 = 0.1231 nM | SANGER | ||
| RT-112 | Growth inhibition assay | IC50 = 0.1273 nM | SANGER | ||
| MCF7 | Growth inhibition assay | IC50 = 0.1359 nM | SANGER | ||
| IGROV-1 | Growth inhibition assay | IC50 = 0.145 nM | SANGER | ||
| OCI-AML2 | Growth inhibition assay | IC50 = 0.1466 nM | SANGER | ||
| NCI-H1299 | Growth inhibition assay | IC50 = 0.1566 nM | SANGER | ||
| A431 | Growth inhibition assay | IC50 = 0.1831 nM | SANGER | ||
| SW982 | Growth inhibition assay | IC50 = 0.2133 nM | SANGER | ||
| BB30-HNC | Growth inhibition assay | IC50 = 0.2312 nM | SANGER | ||
| ACN | Growth inhibition assay | IC50 = 0.2436 nM | SANGER | ||
| 647-V | Growth inhibition assay | IC50 = 0.2481 nM | SANGER | ||
| SK-PN-DW | Growth inhibition assay | IC50 = 0.2656 nM | SANGER | ||
| LCLC-97TM1 | Growth inhibition assay | IC50 = 0.2673 nM | SANGER | ||
| LB1047-RCC | Growth inhibition assay | IC50 = 0.2688 nM | SANGER | ||
| A2780 | Growth inhibition assay | IC50 = 0.2702 nM | SANGER | ||
| C-33-A | Growth inhibition assay | IC50 = 0.2733 nM | SANGER | ||
| NCI-H2228 | Growth inhibition assay | IC50 = 0.314 nM | SANGER | ||
| TE-5 | Growth inhibition assay | IC50 = 0.3157 nM | SANGER | ||
| HC-1 | Growth inhibition assay | IC50 = 0.3273 nM | SANGER | ||
| SK-MES-1 | Growth inhibition assay | IC50 = 0.3279 nM | SANGER | ||
| NCI-H1355 | Growth inhibition assay | IC50 = 0.3806 nM | SANGER | ||
| YKG-1 | Growth inhibition assay | IC50 = 0.4194 nM | SANGER | ||
| RS4-11 | Growth inhibition assay | IC50 = 0.4326 nM | SANGER | ||
| Daoy | Growth inhibition assay | IC50 = 0.4565 nM | SANGER | ||
| A3-KAW | Growth inhibition assay | IC50 = 0.5512 nM | SANGER | ||
| SK-MEL-30 | Growth inhibition assay | IC50 = 0.5545 nM | SANGER | ||
| U031 | Growth inhibition assay | IC50 = 0.5647 nM | SANGER | ||
| SK-LMS-1 | Growth inhibition assay | IC50 = 0.5776 nM | SANGER | ||
| ES6 | Growth inhibition assay | IC50 = 0.5856 nM | SANGER | ||
| EoL-1-cell | Growth inhibition assay | IC50 = 0.6162 nM | SANGER | ||
| NCI-H2009 | Growth inhibition assay | IC50 = 0.6187 nM | SANGER | ||
| A4-Fuk | Growth inhibition assay | IC50 = 0.6263 nM | SANGER | ||
| KYSE-270 | Growth inhibition assay | IC50 = 0.6341 nM | SANGER | ||
| SK-LU-1 | Growth inhibition assay | IC50 = 0.6552 nM | SANGER | ||
| SW872 | Growth inhibition assay | IC50 = 0.7647 nM | SANGER | ||
| ES8 | Growth inhibition assay | IC50 = 0.7802 nM | SANGER | ||
| G-402 | Growth inhibition assay | IC50 = 0.7844 nM | SANGER | ||
| ATN-1 | Growth inhibition assay | IC50 = 0.8069 nM | SANGER | ||
| DoTc2-4510 | Growth inhibition assay | IC50 = 0.9012 nM | SANGER | ||
| MES-SA | Growth inhibition assay | IC50 = 0.9049 nM | SANGER | ||
| SF268 | Growth inhibition assay | IC50 = 0.9274 nM | SANGER | ||
| SF539 | Growth inhibition assay | IC50 = 1.023 nM | SANGER | ||
| NB69 | Growth inhibition assay | IC50 = 1.046 nM | SANGER | ||
| 8505C | Growth inhibition assay | IC50 = 1.063 nM | SANGER | ||
| CAL-12T | Growth inhibition assay | IC50 = 1.084 nM | SANGER | ||
| BHY | Growth inhibition assay | IC50 = 1.141 nM | SANGER | ||
| LB647-SCLC | Growth inhibition assay | IC50 = 1.18 nM | SANGER | ||
| CAL-62 | Growth inhibition assay | IC50 = 1.215 nM | SANGER | ||
| MEG-01 | Growth inhibition assay | IC50 = 1.266 nM | SANGER | ||
| MG-63 | Growth inhibition assay | IC50 = 1.335 nM | SANGER | ||
| SW620 | Growth inhibition assay | IC50 = 1.346 nM | SANGER | ||
| A388 | Growth inhibition assay | IC50 = 1.365 nM | SANGER | ||
| BCPAP | Growth inhibition assay | IC50 = 1.452 nM | SANGER | ||
| P30-OHK | Growth inhibition assay | IC50 = 1.459 nM | SANGER | ||
| Ca9-22 | Growth inhibition assay | IC50 = 1.538 nM | SANGER | ||
| VMRC-RCZ | Growth inhibition assay | IC50 = 1.542 nM | SANGER | ||
| LOXIMVI | Growth inhibition assay | IC50 = 1.596 nM | SANGER | ||
| L-540 | Growth inhibition assay | IC50 = 1.602 nM | SANGER | ||
| NTERA-S-cl-D1 | Growth inhibition assay | IC50 = 1.641 nM | SANGER | ||
| MFH-ino | Growth inhibition assay | IC50 = 1.656 nM | SANGER | ||
| Calu-6 | Growth inhibition assay | IC50 = 1.735 nM | SANGER | ||
| HEL | Growth inhibition assay | IC50 = 1.791 nM | SANGER | ||
| CAL-33 | Growth inhibition assay | IC50 = 1.893 nM | SANGER | ||
| HSC-3 | Growth inhibition assay | IC50 = 1.905 nM | SANGER | ||
| KU812 | Growth inhibition assay | IC50 = 1.913 nM | SANGER | ||
| EB2 | Growth inhibition assay | IC50 = 2.012 nM | SANGER | ||
| SR | Growth inhibition assay | IC50 = 2.121 nM | SANGER | ||
| NCI-H2087 | Growth inhibition assay | IC50 = 2.143 nM | SANGER | ||
| H4 | Growth inhibition assay | IC50 = 2.175 nM | SANGER | ||
| EW-1 | Growth inhibition assay | IC50 = 2.223 nM | SANGER | ||
| MC-IXC | Growth inhibition assay | IC50 = 2.264 nM | SANGER | ||
| NCI-H727 | Growth inhibition assay | IC50 = 2.506 nM | SANGER | ||
| MRK-nu-1 | Growth inhibition assay | IC50 = 2.567 nM | SANGER | ||
| COLO-668 | Growth inhibition assay | IC50 = 2.66 nM | SANGER | ||
| CGTH-W-1 | Growth inhibition assay | IC50 = 2.723 nM | SANGER | ||
| CHP-212 | Growth inhibition assay | IC50 = 2.752 nM | SANGER | ||
| GI-1 | Growth inhibition assay | IC50 = 2.764 nM | SANGER | ||
| HCC1806 | Growth inhibition assay | IC50 = 2.908 nM | SANGER | ||
| HLE | Growth inhibition assay | IC50 = 3.004 nM | SANGER | ||
| HSC-2 | Growth inhibition assay | IC50 = 3.03 nM | SANGER | ||
| DMS-273 | Growth inhibition assay | IC50 = 3.07 nM | SANGER | ||
| DU-4475 | Growth inhibition assay | IC50 = 3.143 nM | SANGER | ||
| LXF-289 | Growth inhibition assay | IC50 = 3.314 nM | SANGER | ||
| PANC-03-27 | Growth inhibition assay | IC50 = 3.513 nM | SANGER | ||
| GAMG | Growth inhibition assay | IC50 = 3.739 nM | SANGER | ||
| NCI-H522 | Growth inhibition assay | IC50 = 4.337 nM | SANGER | ||
| SW626 | Growth inhibition assay | IC50 = 4.464 nM | SANGER | ||
| HT-144 | Growth inhibition assay | IC50 = 4.92 nM | SANGER | ||
| MEL-HO | Growth inhibition assay | IC50 = 5.162 nM | SANGER | ||
| BE-13 | Growth inhibition assay | IC50 = 5.21 nM | SANGER | ||
| VA-ES-BJ | Growth inhibition assay | IC50 = 5.256 nM | SANGER | ||
| NCI-H441 | Growth inhibition assay | IC50 = 5.597 nM | SANGER | ||
| KP-4 | Growth inhibition assay | IC50 = 5.611 nM | SANGER | ||
| LoVo | Growth inhibition assay | IC50 = 5.714 nM | SANGER | ||
| HT-1080 | Growth inhibition assay | IC50 = 5.834 nM | SANGER | ||
| GB-1 | Growth inhibition assay | IC50 = 5.845 nM | SANGER | ||
| IA-LM | Growth inhibition assay | IC50 = 5.906 nM | SANGER | ||
| 8-MG-BA | Growth inhibition assay | IC50 = 5.93 nM | SANGER | ||
| SK-HEP-1 | Growth inhibition assay | IC50 = 6.136 nM | SANGER | ||
| 697 | Growth inhibition assay | IC50 = 6.247 nM | SANGER | ||
| KYSE-450 | Growth inhibition assay | IC50 = 6.315 nM | SANGER | ||
| HCC2998 | Growth inhibition assay | IC50 = 6.339 nM | SANGER | ||
| HD-MY-Z | Growth inhibition assay | IC50 = 6.679 nM | SANGER | ||
| OS-RC-2 | Growth inhibition assay | IC50 = 6.681 nM | SANGER | ||
| SF126 | Growth inhibition assay | IC50 = 7.054 nM | SANGER | ||
| Ca-Ski | Growth inhibition assay | IC50 = 7.093 nM | SANGER | ||
| NCI-H358 | Growth inhibition assay | IC50 = 7.16 nM | SANGER | ||
| J82 | Growth inhibition assay | IC50 = 7.41 nM | SANGER | ||
| NCI-H2342 | Growth inhibition assay | IC50 = 7.634 nM | SANGER | ||
| OVCAR-8 | Growth inhibition assay | IC50 = 7.904 nM | SANGER | ||
| TE-8 | Growth inhibition assay | IC50 = 8.001 nM | SANGER | ||
| ETK-1 | Growth inhibition assay | IC50 = 8.076 nM | SANGER | ||
| HAL-01 | Growth inhibition assay | IC50 = 8.195 nM | SANGER | ||
| KYSE-150 | Growth inhibition assay | IC50 = 8.469 nM | SANGER | ||
| NCI-H810 | Growth inhibition assay | IC50 = 8.558 nM | SANGER | ||
| ONS-76 | Growth inhibition assay | IC50 = 8.677 nM | SANGER | ||
| NMC-G1 | Growth inhibition assay | IC50 = 8.762 nM | SANGER | ||
| C3A | Growth inhibition assay | IC50 = 8.839 nM | SANGER | ||
| PA-1 | Growth inhibition assay | IC50 = 8.993 nM | SANGER | ||
| SH-4 | Growth inhibition assay | IC50 = 9.022 nM | SANGER | ||
| EFO-27 | Growth inhibition assay | IC50 = 9.046 nM | SANGER | ||
| CAPAN-1 | Growth inhibition assay | IC50 = 9.227 nM | SANGER | ||
| DU-145 | Growth inhibition assay | IC50 = 9.29 nM | SANGER | ||
| A101D | Growth inhibition assay | IC50 = 9.373 nM | SANGER | ||
| ST486 | Growth inhibition assay | IC50 = 9.406 nM | SANGER | ||
| NCI-H1437 | Growth inhibition assay | IC50 = 9.418 nM | SANGER | ||
| HGC-27 | Growth inhibition assay | IC50 = 9.601 nM | SANGER | ||
| 8305C | Growth inhibition assay | IC50 = 9.64 nM | SANGER | ||
| OCUB-M | Growth inhibition assay | IC50 = 10.03 nM | SANGER | ||
| COLO-679 | Growth inhibition assay | IC50 = 10.07 nM | SANGER | ||
| Detroit562 | Growth inhibition assay | IC50 = 10.42 nM | SANGER | ||
| A204 | Growth inhibition assay | IC50 = 11.16 nM | SANGER | ||
| NCI-H1734 | Growth inhibition assay | IC50 = 11.29 nM | SANGER | ||
| MC-CAR | Growth inhibition assay | IC50 = 11.58 nM | SANGER | ||
| NCI-H2170 | Growth inhibition assay | IC50 = 11.97 nM | SANGER | ||
| NCI-SNU-5 | Growth inhibition assay | IC50 = 12.13 nM | SANGER | ||
| HCE-T | Growth inhibition assay | IC50 = 12.42 nM | SANGER | ||
| KYSE-180 | Growth inhibition assay | IC50 = 12.81 nM | SANGER | ||
| C8166 | Growth inhibition assay | IC50 = 13.08 nM | SANGER | ||
| NCI-H460 | Growth inhibition assay | IC50 = 13.54 nM | SANGER | ||
| SNU-449 | Growth inhibition assay | IC50 = 13.77 nM | SANGER | ||
| MDA-MB-468 | Growth inhibition assay | IC50 = 14.12 nM | SANGER | ||
| COR-L23 | Growth inhibition assay | IC50 = 14.13 nM | SANGER | ||
| CTV-1 | Growth inhibition assay | IC50 = 14.14 nM | SANGER | ||
| BL-41 | Growth inhibition assay | IC50 = 14.37 nM | SANGER | ||
| IGR-1 | Growth inhibition assay | IC50 = 14.42 nM | SANGER | ||
| TK10 | Growth inhibition assay | IC50 = 14.49 nM | SANGER | ||
| REH | Growth inhibition assay | IC50 = 14.51 nM | SANGER | ||
| LU-139 | Growth inhibition assay | IC50 = 14.59 nM | SANGER | ||
| KP-N-YS | Growth inhibition assay | IC50 = 14.97 nM | SANGER | ||
| PANC-10-05 | Growth inhibition assay | IC50 = 15.38 nM | SANGER | ||
| HL-60 | Growth inhibition assay | IC50 = 15.69 nM | SANGER | ||
| T84 | Growth inhibition assay | IC50 = 15.96 nM | SANGER | ||
| RPMI-8226 | Growth inhibition assay | IC50 = 16.02 nM | SANGER | ||
| UM-UC-3 | Growth inhibition assay | IC50 = 16.16 nM | SANGER | ||
| TE-10 | Growth inhibition assay | IC50 = 16.21 nM | SANGER | ||
| CAL-148 | Growth inhibition assay | IC50 = 17.23 nM | SANGER | ||
| BV-173 | Growth inhibition assay | IC50 = 17.27 nM | SANGER | ||
| Calu-3 | Growth inhibition assay | IC50 = 17.29 nM | SANGER | ||
| RPMI-2650 | Growth inhibition assay | IC50 = 17.59 nM | SANGER | ||
| MKN45 | Growth inhibition assay | IC50 = 17.73 nM | SANGER | ||
| NUGC-3 | Growth inhibition assay | IC50 = 18.34 nM | SANGER | ||
| NCI-H520 | Growth inhibition assay | IC50 = 18.77 nM | SANGER | ||
| CCRF-CEM | Growth inhibition assay | IC50 = 18.85 nM | SANGER | ||
| NCI-H2405 | Growth inhibition assay | IC50 = 19.1 nM | SANGER | ||
| ES7 | Growth inhibition assay | IC50 = 19.76 nM | SANGER | ||
| BPH-1 | Growth inhibition assay | IC50 = 20.28 nM | SANGER | ||
| SAS | Growth inhibition assay | IC50 = 20.5 nM | SANGER | ||
| HuCCT1 | Growth inhibition assay | IC50 = 20.58 nM | SANGER | ||
| LOUCY | Growth inhibition assay | IC50 = 20.66 nM | SANGER | ||
| NCI-H292 | Growth inhibition assay | IC50 = 20.79 nM | SANGER | ||
| G-361 | Growth inhibition assay | IC50 = 21.07 nM | SANGER | ||
| M059J | Growth inhibition assay | IC50 = 21.08 nM | SANGER | ||
| NCI-H1651 | Growth inhibition assay | IC50 = 21.11 nM | SANGER | ||
| KALS-1 | Growth inhibition assay | IC50 = 21.39 nM | SANGER | ||
| DJM-1 | Growth inhibition assay | IC50 = 21.59 nM | SANGER | ||
| AU565 | Growth inhibition assay | IC50 = 21.83 nM | SANGER | ||
| HCC38 | Growth inhibition assay | IC50 = 21.95 nM | SANGER | ||
| U251 | Growth inhibition assay | IC50 = 22.27 nM | SANGER | ||
| ABC-1 | Growth inhibition assay | IC50 = 22.65 nM | SANGER | ||
| SK-NEP-1 | Growth inhibition assay | IC50 = 22.93 nM | SANGER | ||
| CESS | Growth inhibition assay | IC50 = 23.19 nM | SANGER | ||
| MIA-PaCa-2 | Growth inhibition assay | IC50 = 23.36 nM | SANGER | ||
| SUP-T1 | Growth inhibition assay | IC50 = 23.47 nM | SANGER | ||
| L-428 | Growth inhibition assay | IC50 = 23.62 nM | SANGER | ||
| SW954 | Growth inhibition assay | IC50 = 23.68 nM | SANGER | ||
| HO-1-N-1 | Growth inhibition assay | IC50 = 23.77 nM | SANGER | ||
| CHP-126 | Growth inhibition assay | IC50 = 24.14 nM | SANGER | ||
| HMV-II | Growth inhibition assay | IC50 = 24.34 nM | SANGER | ||
| NB10 | Growth inhibition assay | IC50 = 24.37 nM | SANGER | ||
| A172 | Growth inhibition assay | IC50 = 24.71 nM | SANGER | ||
| MONO-MAC-6 | Growth inhibition assay | IC50 = 24.84 nM | SANGER | ||
| NCI-H1650 | Growth inhibition assay | IC50 = 25.4 nM | SANGER | ||
| NH-12 | Growth inhibition assay | IC50 = 25.5 nM | SANGER | ||
| ML-2 | Growth inhibition assay | IC50 = 25.74 nM | SANGER | ||
| MZ2-MEL | Growth inhibition assay | IC50 = 26.22 nM | SANGER | ||
| COLO-684 | Growth inhibition assay | IC50 = 26.41 nM | SANGER | ||
| HuP-T4 | Growth inhibition assay | IC50 = 27.3 nM | SANGER | ||
| SW837 | Growth inhibition assay | IC50 = 27.62 nM | SANGER | ||
| MDA-MB-231 | Growth inhibition assay | IC50 = 27.78 nM | SANGER | ||
| KYSE-140 | Growth inhibition assay | IC50 = 27.91 nM | SANGER | ||
| NOMO-1 | Growth inhibition assay | IC50 = 28.68 nM | SANGER | ||
| GP5d | Growth inhibition assay | IC50 = 28.72 nM | SANGER | ||
| COR-L105 | Growth inhibition assay | IC50 = 29.42 nM | SANGER | ||
| LS-411N | Growth inhibition assay | IC50 = 29.88 nM | SANGER | ||
| NY | Growth inhibition assay | IC50 = 30.18 nM | SANGER | ||
| NCI-H2030 | Growth inhibition assay | IC50 = 30.45 nM | SANGER | ||
| CCF-STTG1 | Growth inhibition assay | IC50 = 31.42 nM | SANGER | ||
| NCI-H1703 | Growth inhibition assay | IC50 = 31.78 nM | SANGER | ||
| TUR | Growth inhibition assay | IC50 = 32.03 nM | SANGER | ||
| NOS-1 | Growth inhibition assay | IC50 = 32.44 nM | SANGER | ||
| A2058 | Growth inhibition assay | IC50 = 32.83 nM | SANGER | ||
| LCLC-103H | Growth inhibition assay | IC50 = 33.25 nM | SANGER | ||
| NCI-H510A | Growth inhibition assay | IC50 = 33.27 nM | SANGER | ||
| BC-1 | Growth inhibition assay | IC50 = 33.77 nM | SANGER | ||
| SK-CO-1 | Growth inhibition assay | IC50 = 34.01 nM | SANGER | ||
| A673 | Growth inhibition assay | IC50 = 34.17 nM | SANGER | ||
| VM-CUB-1 | Growth inhibition assay | IC50 = 34.69 nM | SANGER | ||
| HH | Growth inhibition assay | IC50 = 35.06 nM | SANGER | ||
| CAL-27 | Growth inhibition assay | IC50 = 35.16 nM | SANGER | ||
| NEC8 | Growth inhibition assay | IC50 = 35.37 nM | SANGER | ||
| BxPC-3 | Growth inhibition assay | IC50 = 36.91 nM | SANGER | ||
| SNB75 | Growth inhibition assay | IC50 = 37.24 nM | SANGER | ||
| NB13 | Growth inhibition assay | IC50 = 38.23 nM | SANGER | ||
| SK-OV-3 | Growth inhibition assay | IC50 = 38.74 nM | SANGER | ||
| ME-180 | Growth inhibition assay | IC50 = 38.8 nM | SANGER | ||
| JiyoyeP-2003 | Growth inhibition assay | IC50 = 39.38 nM | SANGER | ||
| LU-134-A | Growth inhibition assay | IC50 = 40.02 nM | SANGER | ||
| LS-123 | Growth inhibition assay | IC50 = 40.28 nM | SANGER | ||
| COLO-800 | Growth inhibition assay | IC50 = 40.56 nM | SANGER | ||
| LB831-BLC | Growth inhibition assay | IC50 = 41.85 nM | SANGER | ||
| NCI-H747 | Growth inhibition assay | IC50 = 42.28 nM | SANGER | ||
| MZ7-mel | Growth inhibition assay | IC50 = 42.66 nM | SANGER | ||
| GT3TKB | Growth inhibition assay | IC50 = 42.72 nM | SANGER | ||
| 23132-87 | Growth inhibition assay | IC50 = 43.05 nM | SANGER | ||
| MOLT-16 | Growth inhibition assay | IC50 = 43.05 nM | SANGER | ||
| PF-382 | Growth inhibition assay | IC50 = 44.22 nM | SANGER | ||
| ES3 | Growth inhibition assay | IC50 = 44.6 nM | SANGER | ||
| SW756 | Growth inhibition assay | IC50 = 45.14 nM | SANGER | ||
| OAW-28 | Growth inhibition assay | IC50 = 45.36 nM | SANGER | ||
| RPMI-8402 | Growth inhibition assay | IC50 = 45.93 nM | SANGER | ||
| NCI-H1693 | Growth inhibition assay | IC50 = 46.09 nM | SANGER | ||
| MS-1 | Growth inhibition assay | IC50 = 46.34 nM | SANGER | ||
| WSU-NHL | Growth inhibition assay | IC50 = 50.35 nM | SANGER | ||
| HCT-116 | Growth inhibition assay | IC50 = 50.83 nM | SANGER | ||
| SF295 | Growth inhibition assay | IC50 = 51.12 nM | SANGER | ||
| MFE-296 | Growth inhibition assay | IC50 = 51.35 nM | SANGER | ||
| NCI-H209 | Growth inhibition assay | IC50 = 52.07 nM | SANGER | ||
| SW962 | Growth inhibition assay | IC50 = 52.41 nM | SANGER | ||
| CTB-1 | Growth inhibition assay | IC50 = 53.39 nM | SANGER | ||
| EFO-21 | Growth inhibition assay | IC50 = 53.66 nM | SANGER | ||
| A704 | Growth inhibition assay | IC50 = 53.78 nM | SANGER | ||
| COR-L279 | Growth inhibition assay | IC50 = 53.91 nM | SANGER | ||
| HN | Growth inhibition assay | IC50 = 54.09 nM | SANGER | ||
| Caov-3 | Growth inhibition assay | IC50 = 54.13 nM | SANGER | ||
| NCI-H1770 | Growth inhibition assay | IC50 = 55.04 nM | SANGER | ||
| G-401 | Growth inhibition assay | IC50 = 55.16 nM | SANGER | ||
| KYSE-410 | Growth inhibition assay | IC50 = 55.87 nM | SANGER | ||
| OE33 | Growth inhibition assay | IC50 = 61.17 nM | SANGER | ||
| NCI-H1694 | Growth inhibition assay | IC50 = 61.29 nM | SANGER | ||
| KG-1 | Growth inhibition assay | IC50 = 62.2 nM | SANGER | ||
| SNU-423 | Growth inhibition assay | IC50 = 62.48 nM | SANGER | ||
| GDM-1 | Growth inhibition assay | IC50 = 62.54 nM | SANGER | ||
| SU-DHL-1 | Growth inhibition assay | IC50 = 62.66 nM | SANGER | ||
| LB2518-MEL | Growth inhibition assay | IC50 = 64.52 nM | SANGER | ||
| LB996-RCC | Growth inhibition assay | IC50 = 65.09 nM | SANGER | ||
| MOLT-4 | Growth inhibition assay | IC50 = 65.28 nM | SANGER | ||
| J-RT3-T3-5 | Growth inhibition assay | IC50 = 67.18 nM | SANGER | ||
| HCC1599 | Growth inhibition assay | IC50 = 70.22 nM | SANGER | ||
| TYK-nu | Growth inhibition assay | IC50 = 72.64 nM | SANGER | ||
| EW-18 | Growth inhibition assay | IC50 = 72.75 nM | SANGER | ||
| LC4-1 | Growth inhibition assay | IC50 = 74.74 nM | SANGER | ||
| COLO-680N | Growth inhibition assay | IC50 = 75.49 nM | SANGER | ||
| MKN1 | Growth inhibition assay | IC50 = 78.37 nM | SANGER | ||
| HCT-15 | Growth inhibition assay | IC50 = 82.16 nM | SANGER | ||
| NCI-H1882 | Growth inhibition assay | IC50 = 82.45 nM | SANGER | ||
| IMR-5 | Growth inhibition assay | IC50 = 82.96 nM | SANGER | ||
| DB | Growth inhibition assay | IC50 = 84.4 nM | SANGER | ||
| P12-ICHIKAWA | Growth inhibition assay | IC50 = 84.7 nM | SANGER | ||
| KARPAS-422 | Growth inhibition assay | IC50 = 85.79 nM | SANGER | ||
| SK-N-DZ | Growth inhibition assay | IC50 = 86.56 nM | SANGER | ||
| FTC-133 | Growth inhibition assay | IC50 = 87.49 nM | SANGER | ||
| SCC-3 | Growth inhibition assay | IC50 = 89.64 nM | SANGER | ||
| KM12 | Growth inhibition assay | IC50 = 91.49 nM | SANGER | ||
| OAW-42 | Growth inhibition assay | IC50 = 92.14 nM | SANGER | ||
| GCIY | Growth inhibition assay | IC50 = 92.69 nM | SANGER | ||
| KYSE-520 | Growth inhibition assay | IC50 = 92.84 nM | SANGER | ||
| RPMI-8866 | Growth inhibition assay | IC50 = 95.23 nM | SANGER | ||
| L-363 | Growth inhibition assay | IC50 = 95.5 nM | SANGER | ||
| 22RV1 | Growth inhibition assay | IC50 = 96.48 nM | SANGER | ||
| DSH1 | Growth inhibition assay | IC50 = 96.5 nM | SANGER | ||
| A253 | Growth inhibition assay | IC50 = 102.28 nM | SANGER | ||
| NCI-H661 | Growth inhibition assay | IC50 = 104.02 nM | SANGER | ||
| SK-MEL-3 | Growth inhibition assay | IC50 = 105.1 nM | SANGER | ||
| FADU | Growth inhibition assay | IC50 = 105.45 nM | SANGER | ||
| SJRH30 | Growth inhibition assay | IC50 = 106.41 nM | SANGER | ||
| HCC1569 | Growth inhibition assay | IC50 = 109.36 nM | SANGER | ||
| NCI-H526 | Growth inhibition assay | IC50 = 109.88 nM | SANGER | ||
| BL-70 | Growth inhibition assay | IC50 = 110.97 nM | SANGER | ||
| SW1990 | Growth inhibition assay | IC50 = 113.07 nM | SANGER | ||
| LAMA-84 | Growth inhibition assay | IC50 = 115.04 nM | SANGER | ||
| COLO-741 | Growth inhibition assay | IC50 = 120.12 nM | SANGER | ||
| SCC-15 | Growth inhibition assay | IC50 = 121.13 nM | SANGER | ||
| DBTRG-05MG | Growth inhibition assay | IC50 = 121.82 nM | SANGER | ||
| HEC-1 | Growth inhibition assay | IC50 = 123.63 nM | SANGER | ||
| D-283MED | Growth inhibition assay | IC50 = 126.98 nM | SANGER | ||
| RD | Growth inhibition assay | IC50 = 130.11 nM | SANGER | ||
| K052 | Growth inhibition assay | IC50 = 136.71 nM | SANGER | ||
| CAL-85-1 | Growth inhibition assay | IC50 = 144.63 nM | SANGER | ||
| NCI-H2052 | Growth inhibition assay | IC50 = 144.82 nM | SANGER | ||
| BFTC-909 | Growth inhibition assay | IC50 = 145.6 nM | SANGER | ||
| HuP-T3 | Growth inhibition assay | IC50 = 145.65 nM | SANGER | ||
| NCI-H64 | Growth inhibition assay | IC50 = 150.93 nM | SANGER | ||
| C-4-II | Growth inhibition assay | IC50 = 152.37 nM | SANGER | ||
| KMOE-2 | Growth inhibition assay | IC50 = 154.93 nM | SANGER | ||
| NB12 | Growth inhibition assay | IC50 = 155.15 nM | SANGER | ||
| EM-2 | Growth inhibition assay | IC50 = 159.9 nM | SANGER | ||
| SIMA | Growth inhibition assay | IC50 = 161.25 nM | SANGER | ||
| SBC-1 | Growth inhibition assay | IC50 = 165.57 nM | SANGER | ||
| KS-1 | Growth inhibition assay | IC50 = 166.52 nM | SANGER | ||
| no-10 | Growth inhibition assay | IC50 = 173.76 nM | SANGER | ||
| NCCIT | Growth inhibition assay | IC50 = 176.26 nM | SANGER | ||
| RERF-LC-MS | Growth inhibition assay | IC50 = 176.69 nM | SANGER | ||
| BT-20 | Growth inhibition assay | IC50 = 181.74 nM | SANGER | ||
| NCI-H1623 | Growth inhibition assay | IC50 = 187.08 nM | SANGER | ||
| TE-9 | Growth inhibition assay | IC50 = 189.63 nM | SANGER | ||
| U-87-MG | Growth inhibition assay | IC50 = 190.57 nM | SANGER | ||
| CAL-51 | Growth inhibition assay | IC50 = 191.14 nM | SANGER | ||
| 639-V | Growth inhibition assay | IC50 = 193.14 nM | SANGER | ||
| SJSA-1 | Growth inhibition assay | IC50 = 195.01 nM | SANGER | ||
| DOHH-2 | Growth inhibition assay | IC50 = 195.64 nM | SANGER | ||
| IST-SL1 | Growth inhibition assay | IC50 = 197.47 nM | SANGER | ||
| NCI-H1618 | Growth inhibition assay | IC50 = 197.56 nM | SANGER | ||
| TGW | Growth inhibition assay | IC50 = 199.64 nM | SANGER | ||
| HT-3 | Growth inhibition assay | IC50 = 0.20054 μM | SANGER | ||
| AN3-CA | Growth inhibition assay | IC50 = 0.20329 μM | SANGER | ||
| PC-14 | Growth inhibition assay | IC50 = 0.20331 μM | SANGER | ||
| BHT-101 | Growth inhibition assay | IC50 = 0.21039 μM | SANGER | ||
| NCI-H23 | Growth inhibition assay | IC50 = 0.21106 μM | SANGER | ||
| SCC-4 | Growth inhibition assay | IC50 = 0.21185 μM | SANGER | ||
| EGI-1 | Growth inhibition assay | IC50 = 0.21386 μM | SANGER | ||
| Calu-1 | Growth inhibition assay | IC50 = 0.22003 μM | SANGER | ||
| BC-3 | Growth inhibition assay | IC50 = 0.22065 μM | SANGER | ||
| HOP-62 | Growth inhibition assay | IC50 = 0.22258 μM | SANGER | ||
| NCI-H1793 | Growth inhibition assay | IC50 = 0.22363 μM | SANGER | ||
| COLO-320-HSR | Growth inhibition assay | IC50 = 0.22408 μM | SANGER | ||
| NCI-H596 | Growth inhibition assay | IC50 = 0.22513 μM | SANGER | ||
| EHEB | Growth inhibition assay | IC50 = 0.22651 μM | SANGER | ||
| BEN | Growth inhibition assay | IC50 = 0.23791 μM | SANGER | ||
| MHH-PREB-1 | Growth inhibition assay | IC50 = 0.24804 μM | SANGER | ||
| TE-6 | Growth inhibition assay | IC50 = 0.25035 μM | SANGER | ||
| KARPAS-299 | Growth inhibition assay | IC50 = 0.252 μM | SANGER | ||
| BOKU | Growth inhibition assay | IC50 = 0.25433 μM | SANGER | ||
| MZ1-PC | Growth inhibition assay | IC50 = 0.25435 μM | SANGER | ||
| IPC-298 | Growth inhibition assay | IC50 = 0.25477 μM | SANGER | ||
| NCI-H1792 | Growth inhibition assay | IC50 = 0.25904 μM | SANGER | ||
| KM-H2 | Growth inhibition assay | IC50 = 0.26068 μM | SANGER | ||
| Becker | Growth inhibition assay | IC50 = 0.26704 μM | SANGER | ||
| NCI-H446 | Growth inhibition assay | IC50 = 0.26911 μM | SANGER | ||
| MLMA | Growth inhibition assay | IC50 = 0.27156 μM | SANGER | ||
| JEG-3 | Growth inhibition assay | IC50 = 0.27669 μM | SANGER | ||
| SCC-25 | Growth inhibition assay | IC50 = 0.28928 μM | SANGER | ||
| CA46 | Growth inhibition assay | IC50 = 0.29339 μM | SANGER | ||
| CAL-54 | Growth inhibition assay | IC50 = 0.29759 μM | SANGER | ||
| KYSE-70 | Growth inhibition assay | IC50 = 0.29969 μM | SANGER | ||
| LU-65 | Growth inhibition assay | IC50 = 0.30381 μM | SANGER | ||
| OVCAR-5 | Growth inhibition assay | IC50 = 0.30577 μM | SANGER | ||
| NCI-H2081 | Growth inhibition assay | IC50 = 0.31077 μM | SANGER | ||
| NCI-H226 | Growth inhibition assay | IC50 = 0.31696 μM | SANGER | ||
| A427 | Growth inhibition assay | IC50 = 0.32398 μM | SANGER | ||
| CPC-N | Growth inhibition assay | IC50 = 0.329 μM | SANGER | ||
| SW13 | Growth inhibition assay | IC50 = 0.33037 μM | SANGER | ||
| K-562 | Growth inhibition assay | IC50 = 0.33298 μM | SANGER | ||
| NCI-N87 | Growth inhibition assay | IC50 = 0.33304 μM | SANGER | ||
| U-698-M | Growth inhibition assay | IC50 = 0.34453 μM | SANGER | ||
| IM-9 | Growth inhibition assay | IC50 = 0.34691 μM | SANGER | ||
| NCI-H748 | Growth inhibition assay | IC50 = 0.35458 μM | SANGER | ||
| UACC-257 | Growth inhibition assay | IC50 = 0.36412 μM | SANGER | ||
| HT-1376 | Growth inhibition assay | IC50 = 0.36895 μM | SANGER | ||
| GAK | Growth inhibition assay | IC50 = 0.37294 μM | SANGER | ||
| NCI-H82 | Growth inhibition assay | IC50 = 0.37297 μM | SANGER | ||
| NCI-H1304 | Growth inhibition assay | IC50 = 0.38454 μM | SANGER | ||
| MHH-NB-11 | Growth inhibition assay | IC50 = 0.38597 μM | SANGER | ||
| CAMA-1 | Growth inhibition assay | IC50 = 0.3958 μM | SANGER | ||
| GCT | Growth inhibition assay | IC50 = 0.4051 μM | SANGER | ||
| HPAF-II | Growth inhibition assay | IC50 = 0.42847 μM | SANGER | ||
| Raji | Growth inhibition assay | IC50 = 0.43145 μM | SANGER | ||
| EW-11 | Growth inhibition assay | IC50 = 0.43352 μM | SANGER | ||
| SW1573 | Growth inhibition assay | IC50 = 0.45733 μM | SANGER | ||
| KLE | Growth inhibition assay | IC50 = 0.45942 μM | SANGER | ||
| NCI-H69 | Growth inhibition assay | IC50 = 0.45948 μM | SANGER | ||
| MDA-MB-361 | Growth inhibition assay | IC50 = 0.46064 μM | SANGER | ||
| SW48 | Growth inhibition assay | IC50 = 0.46259 μM | SANGER | ||
| SK-MM-2 | Growth inhibition assay | IC50 = 0.47912 μM | SANGER | ||
| MC116 | Growth inhibition assay | IC50 = 0.48166 μM | SANGER | ||
| NB1 | Growth inhibition assay | IC50 = 0.48753 μM | SANGER | ||
| NCI-H1155 | Growth inhibition assay | IC50 = 0.48828 μM | SANGER | ||
| SN12C | Growth inhibition assay | IC50 = 0.49734 μM | SANGER | ||
| NCI-H838 | Growth inhibition assay | IC50 = 0.49875 μM | SANGER | ||
| SW1463 | Growth inhibition assay | IC50 = 0.51017 μM | SANGER | ||
| NCI-H1648 | Growth inhibition assay | IC50 = 0.51081 μM | SANGER | ||
| M14 | Growth inhibition assay | IC50 = 0.51466 μM | SANGER | ||
| T98G | Growth inhibition assay | IC50 = 0.53948 μM | SANGER | ||
| CaR-1 | Growth inhibition assay | IC50 = 0.55122 μM | SANGER | ||
| NCI-H650 | Growth inhibition assay | IC50 = 0.56569 μM | SANGER | ||
| HuH-7 | Growth inhibition assay | IC50 = 0.56861 μM | SANGER | ||
| Daudi | Growth inhibition assay | IC50 = 0.56949 μM | SANGER | ||
| CAL-120 | Growth inhibition assay | IC50 = 0.57588 μM | SANGER | ||
| EW-3 | Growth inhibition assay | IC50 = 0.57956 μM | SANGER | ||
| OMC-1 | Growth inhibition assay | IC50 = 0.58333 μM | SANGER | ||
| U-266 | Growth inhibition assay | IC50 = 0.60794 μM | SANGER | ||
| OVCAR-4 | Growth inhibition assay | IC50 = 0.62523 μM | SANGER | ||
| RCC10RGB | Growth inhibition assay | IC50 = 0.63374 μM | SANGER | ||
| NCI-H2141 | Growth inhibition assay | IC50 = 0.64404 μM | SANGER | ||
| Ramos-2G6-4C10 | Growth inhibition assay | IC50 = 0.66087 μM | SANGER | ||
| THP-1 | Growth inhibition assay | IC50 = 0.6642 μM | SANGER | ||
| RCM-1 | Growth inhibition assay | IC50 = 0.66478 μM | SANGER | ||
| K5 | Growth inhibition assay | IC50 = 0.68269 μM | SANGER | ||
| MPP-89 | Growth inhibition assay | IC50 = 0.69228 μM | SANGER | ||
| ChaGo-K-1 | Growth inhibition assay | IC50 = 0.6956 μM | SANGER | ||
| OE19 | Growth inhibition assay | IC50 = 0.70216 μM | SANGER | ||
| NCI-H1755 | Growth inhibition assay | IC50 = 0.71816 μM | SANGER | ||
| KNS-42 | Growth inhibition assay | IC50 = 0.73582 μM | SANGER | ||
| no-11 | Growth inhibition assay | IC50 = 0.73668 μM | SANGER | ||
| IST-MES1 | Growth inhibition assay | IC50 = 0.77354 μM | SANGER | ||
| NCI-H2347 | Growth inhibition assay | IC50 = 0.79201 μM | SANGER | ||
| SKG-IIIa | Growth inhibition assay | IC50 = 0.80972 μM | SANGER | ||
| UACC-62 | Growth inhibition assay | IC50 = 0.8126 μM | SANGER | ||
| SNU-387 | Growth inhibition assay | IC50 = 0.82744 μM | SANGER | ||
| LS-513 | Growth inhibition assay | IC50 = 0.88761 μM | SANGER | ||
| NCI-H719 | Growth inhibition assay | IC50 = 0.89157 μM | SANGER | ||
| HOP-92 | Growth inhibition assay | IC50 = 0.95075 μM | SANGER | ||
| CAS-1 | Growth inhibition assay | IC50 = 0.95508 μM | SANGER | ||
| HTC-C3 | Growth inhibition assay | IC50 = 0.9965 μM | SANGER | ||
| D-392MG | Growth inhibition assay | IC50 = 1.02288 μM | SANGER | ||
| MHH-CALL-2 | Growth inhibition assay | IC50 = 1.02319 μM | SANGER | ||
| DMS-53 | Growth inhibition assay | IC50 = 1.03815 μM | SANGER | ||
| TGBC24TKB | Growth inhibition assay | IC50 = 1.04183 μM | SANGER | ||
| NCI-H1417 | Growth inhibition assay | IC50 = 1.07075 μM | SANGER | ||
| OVCAR-3 | Growth inhibition assay | IC50 = 1.0739 μM | SANGER | ||
| RXF393 | Growth inhibition assay | IC50 = 1.1432 μM | SANGER | ||
| MKN28 | Growth inhibition assay | IC50 = 1.15124 μM | SANGER | ||
| MSTO-211H | Growth inhibition assay | IC50 = 1.15257 μM | SANGER | ||
| NCI-H2126 | Growth inhibition assay | IC50 = 1.15799 μM | SANGER | ||
| TCCSUP | Growth inhibition assay | IC50 = 1.16785 μM | SANGER | ||
| TE-12 | Growth inhibition assay | IC50 = 1.17366 μM | SANGER | ||
| NCI-H1581 | Growth inhibition assay | IC50 = 1.17372 μM | SANGER | ||
| GOTO | Growth inhibition assay | IC50 = 1.20277 μM | SANGER | ||
| NCI-H28 | Growth inhibition assay | IC50 = 1.2149 μM | SANGER | ||
| KNS-81-FD | Growth inhibition assay | IC50 = 1.23463 μM | SANGER | ||
| YT | Growth inhibition assay | IC50 = 1.28559 μM | SANGER | ||
| NB5 | Growth inhibition assay | IC50 = 1.32585 μM | SANGER | ||
| U-118-MG | Growth inhibition assay | IC50 = 1.35159 μM | SANGER | ||
| LS-1034 | Growth inhibition assay | IC50 = 1.3845 μM | SANGER | ||
| PANC-08-13 | Growth inhibition assay | IC50 = 1.39613 μM | SANGER | ||
| COLO-205 | Growth inhibition assay | IC50 = 1.47181 μM | SANGER | ||
| KURAMOCHI | Growth inhibition assay | IC50 = 1.49739 μM | SANGER | ||
| SNU-C2B | Growth inhibition assay | IC50 = 1.54777 μM | SANGER | ||
| HDLM-2 | Growth inhibition assay | IC50 = 1.63327 μM | SANGER | ||
| PFSK-1 | Growth inhibition assay | IC50 = 1.64794 μM | SANGER | ||
| SW1088 | Growth inhibition assay | IC50 = 1.66167 μM | SANGER | ||
| LB373-MEL-D | Growth inhibition assay | IC50 = 1.66495 μM | SANGER | ||
| HT-1197 | Growth inhibition assay | IC50 = 1.76425 μM | SANGER | ||
| MMAC-SF | Growth inhibition assay | IC50 = 1.7766 μM | SANGER | ||
| T-24 | Growth inhibition assay | IC50 = 2.07629 μM | SANGER | ||
| LK-2 | Growth inhibition assay | IC50 = 2.08563 μM | SANGER | ||
| 5637 | Growth inhibition assay | IC50 = 2.10298 μM | SANGER | ||
| GI-ME-N | Growth inhibition assay | IC50 = 2.10851 μM | SANGER | ||
| NCI-H2196 | Growth inhibition assay | IC50 = 2.31034 μM | SANGER | ||
| KOSC-2 | Growth inhibition assay | IC50 = 2.35338 μM | SANGER | ||
| MN-60 | Growth inhibition assay | IC50 = 2.43457 μM | SANGER | ||
| AsPC-1 | Growth inhibition assay | IC50 = 2.50301 μM | SANGER | ||
| MDA-MB-175-VII | Growth inhibition assay | IC50 = 2.51493 μM | SANGER | ||
| DG-75 | Growth inhibition assay | IC50 = 2.5612 μM | SANGER | ||
| LNCaP-Clone-FGC | Growth inhibition assay | IC50 = 2.65415 μM | SANGER | ||
| SCLC-21H | Growth inhibition assay | IC50 = 2.77414 μM | SANGER | ||
| EFE-184 | Growth inhibition assay | IC50 = 2.79042 μM | SANGER | ||
| HCC2157 | Growth inhibition assay | IC50 = 2.80678 μM | SANGER | ||
| NCI-H1573 | Growth inhibition assay | IC50 = 2.80723 μM | SANGER | ||
| PC-3 | Growth inhibition assay | IC50 = 2.83163 μM | SANGER | ||
| KY821 | Growth inhibition assay | IC50 = 2.8814 μM | SANGER | ||
| ECC4 | Growth inhibition assay | IC50 = 2.92765 μM | SANGER | ||
| SK-N-AS | Growth inhibition assay | IC50 = 2.96758 μM | SANGER | ||
| NB6 | Growth inhibition assay | IC50 = 3.2819 μM | SANGER | ||
| KMS-12-PE | Growth inhibition assay | IC50 = 3.55998 μM | SANGER | ||
| NCI-H2171 | Growth inhibition assay | IC50 = 3.76535 μM | SANGER | ||
| TE-11 | Growth inhibition assay | IC50 = 4.09997 μM | SANGER | ||
| DMS-153 | Growth inhibition assay | IC50 = 4.10246 μM | SANGER | ||
| RVH-421 | Growth inhibition assay | IC50 = 4.11559 μM | SANGER | ||
| RO82-W-1 | Growth inhibition assay | IC50 = 4.42356 μM | SANGER | ||
| TE-1 | Growth inhibition assay | IC50 = 5.86741 μM | SANGER | ||
| MFE-280 | Growth inhibition assay | IC50 = 5.90388 μM | SANGER | ||
| HT | Growth inhibition assay | IC50 = 5.93153 μM | SANGER | ||
| NCI-H1963 | Growth inhibition assay | IC50 = 6.26713 μM | SANGER | ||
| S-117 | Growth inhibition assay | IC50 = 6.30327 μM | SANGER | ||
| TGBC1TKB | Growth inhibition assay | IC50 = 6.51712 μM | SANGER | ||
| NCI-H1522 | Growth inhibition assay | IC50 = 6.53336 μM | SANGER | ||
| TE-441-T | Growth inhibition assay | IC50 = 6.5501 μM | SANGER | ||
| UACC-893 | Growth inhibition assay | IC50 = 6.55203 μM | SANGER | ||
| SHP-77 | Growth inhibition assay | IC50 = 6.85463 μM | SANGER | ||
| TALL-1 | Growth inhibition assay | IC50 = 7.00001 μM | SANGER | ||
| T47D | Growth inhibition assay | IC50 = 7.00094 μM | SANGER | ||
| Capan-2 | Growth inhibition assay | IC50 = 7.09987 μM | SANGER | ||
| SK-MEL-2 | Growth inhibition assay | IC50 = 7.13094 μM | SANGER | ||
| NCI-H1092 | Growth inhibition assay | IC50 = 7.15535 μM | SANGER | ||
| LP-1 | Growth inhibition assay | IC50 = 7.30969 μM | SANGER | ||
| NCI-H889 | Growth inhibition assay | IC50 = 7.57024 μM | SANGER | ||
| NCI-H2452 | Growth inhibition assay | IC50 = 7.63456 μM | SANGER | ||
| UMC-11 | Growth inhibition assay | IC50 = 8.35939 μM | SANGER | ||
| LU-165 | Growth inhibition assay | IC50 = 8.41085 μM | SANGER | ||
| Mewo | Growth inhibition assay | IC50 = 8.43715 μM | SANGER | ||
| C32 | Growth inhibition assay | IC50 = 8.43927 μM | SANGER | ||
| DV-90 | Growth inhibition assay | IC50 = 8.45559 μM | SANGER | ||
| SW1417 | Growth inhibition assay | IC50 = 8.63434 μM | SANGER | ||
| NCI-H187 | Growth inhibition assay | IC50 = 8.85234 μM | SANGER | ||
| LU-99A | Growth inhibition assay | IC50 = 9.13742 μM | SANGER | ||
| DMS-79 | Growth inhibition assay | IC50 = 9.4013 μM | SANGER | ||
| MDA-MB-415 | Growth inhibition assay | IC50 = 9.95336 μM | SANGER | ||
| HCC1954 | Growth inhibition assay | IC50 = 9.97404 μM | SANGER | ||
| EB-3 | Growth inhibition assay | IC50 = 11.1641 μM | SANGER | ||
| CW-2 | Growth inhibition assay | IC50 = 11.2237 μM | SANGER | ||
| COR-L88 | Growth inhibition assay | IC50 = 11.4887 μM | SANGER | ||
| CP50-MEL-B | Growth inhibition assay | IC50 = 11.567 μM | SANGER | ||
| LN-405 | Growth inhibition assay | IC50 = 11.8448 μM | SANGER | ||
| EVSA-T | Growth inhibition assay | IC50 = 11.9609 μM | SANGER | ||
| HCC70 | Growth inhibition assay | IC50 = 12.0511 μM | SANGER | ||
| UACC-812 | Growth inhibition assay | IC50 = 13.3687 μM | SANGER | ||
| LC-1F | Growth inhibition assay | IC50 = 13.4575 μM | SANGER | ||
| HCC1419 | Growth inhibition assay | IC50 = 13.5715 μM | SANGER | ||
| C2BBe1 | Growth inhibition assay | IC50 = 13.6612 μM | SANGER | ||
| COLO-678 | Growth inhibition assay | IC50 = 13.7484 μM | SANGER | ||
| RT4 | Growth inhibition assay | IC50 = 13.8428 μM | SANGER | ||
| NCI-H524 | Growth inhibition assay | IC50 = 15.3769 μM | SANGER | ||
| HCC1143 | Growth inhibition assay | IC50 = 16.3541 μM | SANGER | ||
| HT55 | Growth inhibition assay | IC50 = 16.4103 μM | SANGER | ||
| CAL-39 | Growth inhibition assay | IC50 = 16.6227 μM | SANGER | ||
| KU-19-19 | Growth inhibition assay | IC50 = 16.8123 μM | SANGER | ||
| LB771-HNC | Growth inhibition assay | IC50 = 16.9876 μM | SANGER | ||
| OPM-2 | Growth inhibition assay | IC50 = 17.6337 μM | SANGER | ||
| CAKI-1 | Growth inhibition assay | IC50 = 18.0406 μM | SANGER | ||
| KP-N-YN | Growth inhibition assay | IC50 = 18.8885 μM | SANGER | ||
| SW948 | Growth inhibition assay | IC50 = 20.4975 μM | SANGER | ||
| SK-MEL-1 | Growth inhibition assay | IC50 = 20.6083 μM | SANGER | ||
| NCI-H1563 | Growth inhibition assay | IC50 = 21.5347 μM | SANGER | ||
| GMS-10 | Growth inhibition assay | IC50 = 21.6061 μM | SANGER | ||
| MDA-MB-453 | Growth inhibition assay | IC50 = 22.2184 μM | SANGER | ||
| PLC-PRF-5 | Growth inhibition assay | IC50 = 22.8813 μM | SANGER | ||
| EFM-19 | Growth inhibition assay | IC50 = 24.2029 μM | SANGER | ||
| SK-N-FI | Growth inhibition assay | IC50 = 25.1429 μM | SANGER | ||
| Saos-2 | Growth inhibition assay | IC50 = 26.765 μM | SANGER | ||
| KARPAS-45 | Growth inhibition assay | IC50 = 27.5648 μM | SANGER | ||
| EKVX | Growth inhibition assay | IC50 = 27.7875 μM | SANGER | ||
| KINGS-1 | Growth inhibition assay | IC50 = 30.879 μM | SANGER | ||
| NCI-H2227 | Growth inhibition assay | IC50 = 31.2813 μM | SANGER | ||
| D-542MG | Growth inhibition assay | IC50 = 32.2968 μM | SANGER | ||
| D-263MG | Growth inhibition assay | IC50 = 33.5726 μM | SANGER | ||
| A498 | Growth inhibition assay | IC50 = 38.4491 μM | SANGER | ||
| MDA-MB-157 | Growth inhibition assay | IC50 = 38.5533 μM | SANGER | ||
| RMG-I | Growth inhibition assay | IC50 = 42.9009 μM | SANGER | ||
| COLO-792 | Growth inhibition assay | IC50 = 43.2931 μM | SANGER | ||
| SK-MEL-24 | Growth inhibition assay | IC50 = 43.4294 μM | SANGER | ||
| SNU-475 | Growth inhibition assay | IC50 = 44.5002 μM | SANGER | ||
| HuO-3N1 | Growth inhibition assay | IC50 = 46.3321 μM | SANGER | ||
| LAN-6 | Growth inhibition assay | IC50 = 46.6441 μM | SANGER | ||
| NCI-H720 | Growth inhibition assay | IC50 = 46.7503 μM | SANGER | ||
| BB49-HNC | Growth inhibition assay | IC50 = 47.6209 μM | SANGER | ||
| TT | Growth inhibition assay | IC50 = 49.8459 μM | SANGER | ||
| MDA-MB-231 | Antiproliferative assay | GI50 = 0.000251 μM | 29301085 | ||
| Colo-357 | Cytotoxicity assay | IC50 = 0.00036 μM | 20930123 | ||
| SW620 | Antiproliferative assay | GI50 = 0.00084 μM | 29301085 | ||
| PANC1 | Cytotoxicity assay | IC50 = 0.001 μM | 20930123 | ||
| RT112 | Cytotoxicity assay | EC50 = 0.0014 μM | 24471998 | ||
| A2780 | Growth inhibition assay | IC50 = 0.0015 μM | 17602464 | ||
| T3M4 | Cytotoxicity assay | IC50 = 0.0015 μM | 20930123 | ||
| H460 | Antiproliferative assay | GI50 = 0.002085 μM | 29301085 | ||
| Patu-T | Cytotoxicity assay | IC50 = 0.0028 μM | 20930123 | ||
| HT-29 | Cytotoxicity assay | IC50 = 0.003 μM | 11728191 | ||
| Patu-S | Cytotoxicity assay | IC50 = 0.0032 μM | 20930123 | ||
| Patu-02 | Cytotoxicity assay | IC50 = 0.0034 μM | 20930123 | ||
| DAN-G | Cytotoxicity assay | IC50 = 0.0034 μM | 20930123 | ||
| DU145 | Antiproliferative assay | IC50 = 0.0035 μM | 17887663 | ||
| Aspc-1 | Cytotoxicity assay | IC50 = 0.004 μM | 20930123 | ||
| HCT116 | Cytotoxicity assay | IC50 = 0.005 μM | 19691349 | ||
| NCI-H460 | Cytotoxicity assay | IC50 = 0.0078 μM | 11728191 | ||
| MES-SA | Cytotoxicity assay | IC50 = 0.0092 μM | 11728191 | ||
| H460 | Growth inhibition assay | IC50 = 0.01 μM | 17602464 | ||
| MDA-MB-231 | Antiproliferative assay | IC50 = 0.0114 μM | 17887663 | ||
| H292 | Growth inhibition assay | IC50 = 0.013 μM | 17602464 | ||
| A549 | Growth inhibition assay | IC50 = 0.014 μM | 17602464 | ||
| A2780 | Growth inhibition assay | IC50 = 0.015 μM | 17602464 | ||
| SW1573 | Growth inhibition assay | IC50 = 0.016 μM | 17602464 | ||
| DU-145 | Cytotoxicity assay | IC50 = 0.0356 μM | 11728191 | ||
| PC3 | Cytotoxicity assay | IC50 = 0.04 μM | 19691349 | ||
| A549 | Cytotoxicity assay | IC50 = 0.09 μM | 19691349 | ||
| HuH7 | Cytotoxicity assay | CC50 = 0.1 μM | 20580554 | ||
| H460 | Growth inhibition assay | IC50 = 0.103 μM | 17602464 | ||
| RT112 | Cytotoxicity assay | EC50 = 0.1049 μM | 24471998 | ||
| CEM | Growth inhibition assay | IC50 = 0.13 μM | 17602464 | ||
| H292 | Growth inhibition assay | IC50 = 0.21 μM | 17602464 | ||
| A549 | Growth inhibition assay | IC50 = 0.225 μM | 17602464 | ||
| SW1573 | Growth inhibition assay | IC50 = 0.275 μM | 17602464 | ||
| CEM | Growth inhibition assay | IC50 = 1 μM | 17602464 | ||
| HepG2 | Function assay | Km = 1.4 μM | 17101674 | ||
| BL21(DE3) | Function assay | Km = 1.43 μM | 23230131 | ||
| BL21(DE3) | Function assay | Km = 1.52 μM | 23230131 | ||
| SW1990 | Cytotoxicity assay | IC50 = 1.6 μM | 24195466 | ||
| BL21(DE3) | Function assay | Km = 1.75 μM | 23230131 | ||
| SW1990 | Cytotoxicity assay | IC50 = 2.2 μM | 25105722 | ||
| HCT15 | Cytotoxicity assay | IC50 = 11.8 μM | 18186604 | ||
| HCT116 | Cytotoxicity assay | IC50 = 14.3 μM | 18186604 | ||
| AG6000 | Growth inhibition assay | IC50 = 20 μM | 17602464 | ||
| AG6000 | Growth inhibition assay | IC50 = 20 μM | 17602464 | ||
| 点击查看更多细胞系数据 | |||||
生物活性
| 产品描述 | Gemcitabine HCl是一种DNA synthesis抑制剂，作用于PANC1，MIAPaCa2，BxPC3和Capan2细胞，IC50分别为50 nM， 40 nM， 18 nM和12 nM。 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 特性 | Gemcitabine已经用于治疗胰腺癌，作为最有效的抗癌药物。 | ||||||||
| 靶点 |
|
| 体外研究(In Vitro) | ||||
| 体外研究活性 | Gemcitabine作用于BxPC-3, PANC-1, 和MIA PaCa-2细胞，诱导NF-κB活性，作用于BxPC-3 和PANC-1细胞，降低NF-κB抑制剂 IκBα水平。低剂量Gemcitabine处理BxPC-3细胞48小时提高NF-κB 结合，这种作用存在剂量依赖性。相反, 更高剂量Gemcitabine处理BxPC-3细胞48小时，降低 NF-κB DNA 结合，而更高剂量Gemcitabine处理BxPC-3细胞24小时，提高NF-κB结合。[2] | |||
|---|---|---|---|---|
| 细胞实验 | 细胞系 | BxPC-3, MIA PaCa-2, 和 PANC-1 细胞 | ||
| 浓度 | 0.2 μM | |||
| 孵育时间 | 24 小时或48小时 | |||
| 方法 | BxPC-3, MIA PaCa-2, 和PANC-1 细胞接种在96孔板中。24小时后,使用 DMAPT 和/或 Gemcitabine处理24小时或48小时。使用细胞死亡检测 ELISA测定细胞质组蛋白相关 DNA片段的量，而量化细胞凋亡。 | |||
| 实验图片 | 检测方法 | 检测指标 | 实验图片 | PMID |
| Western blot | p70S6K1 / p-S6 / HIF-1α LC3-I / LC3-II pS-ERα / ERα / pERK / ERK caspase-3 / caspase-8 / caspase-9 p-JNK / JNK / p-ATF2 / p-c-Jun |
|
27765914 | |
| Immunofluorescence | BMI1 |
|
27177084 | |
| Growth inhibition assay | Cell viability |
|
27765914 | |
| 体内研究(In Vivo) | ||
| 体内研究活性 | 与PBS处理的小鼠相比，Gemcitabine处理的小鼠瘤内NF-κB 活性显著提高(提高1.3- 到1.8-倍),说明 Gemcitabine也诱导NF-κB 活性。[2] | |
|---|---|---|
| 动物实验 | Animal Models | 携带MIA PaCa-2细胞的无胸腺裸鼠 |
| Dosages | 50 mg/kg或100 mg/kg | |
| Administration | 腹腔注射 | |
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT06046794 | Not yet recruiting | Cancer Of Pancreas |
Institut Paoli-Calmettes |
February 1 2024 | Not Applicable |
| NCT06055348 | Not yet recruiting | Serous Ovarian Cancer|Advanced Ovarian Cancer |
Biocity Biopharmaceutics Co. Ltd. |
October 30 2023 | Phase 1|Phase 2 |
| NCT06059001 | Recruiting | Metastatic Pancreatic Cancer |
Peptomyc S.L. |
August 31 2023 | Phase 1 |
| NCT05562297 | Not yet recruiting | Pancreatic Cancer Stage IB|Pancreatic Cancer Stage IIA|Pancreatic Cancer Stage IIB|Pancreatic Cancer Stage III |
Shanghai Zhongshan Hospital|Fudan University |
July 1 2023 | Phase 2 |
化学信息&溶解度
| 分子量 | 299.66 | 分子式 | C9H11F2N3O4.HCI |
| CAS号 | 122111-03-9 | SDF | Download Gemcitabine HCl SDF |
| Smiles | C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)(F)F.Cl | ||
| 储存条件(自收到货起) | |||
|
体外溶解度 |
Water : 59 mg/mL DMSO : Insoluble ( DMSO吸湿会降低化合物溶解度，请使用新开封DMSO) Ethanol : Insoluble |
摩尔浓度计算器 |
|
体内溶解度 现配现用，请按从左到右的顺序依次添加，澄清后再加入下一溶剂 |
动物体内配方计算器 | ||||
实验计算
动物体内配方计算器（澄清溶液）
第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）
mg/kg
g
μL
只
第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
计算结果：
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于μL DMSO溶液（母液浓度mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；
体内配方配制方法：取μL DMSO母液，加入μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入μL ddH2O，混匀澄清。
体内配方配制方法：取μL DMSO母液，加入μL Corn oil，混匀澄清。
注意：1. 首先保证母液是澄清的；
2.一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
技术支持
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常见问题及建议解决方法
问题 1:
What’s the difference between S1714 and S1149 and which one is better?
回答：
They have the same biological activities. The free base(S1714) dissolves better in DMSO, and the hydrochloride (S1149) dissolves better in water.
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