Alisertib (MLN8237)

For research use only. Not for use in humans.

目录号:S1133 中文名称:阿利色替

Alisertib (MLN8237) Chemical Structure

CAS No. 1028486-01-2

Alisertib (MLN8237)是一种选择性Aurora A抑制剂,无细胞试验中IC50为1.2 nM,作用于Aurora A比作用于Aurora B选择性强200倍以上。Alisertib 可诱导细胞周期阻滞、细胞凋亡与自噬。Phase 3。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1375.12 现货
RMB 983.87 现货
RMB 1725.78 现货
RMB 5505.84 现货
RMB 14496.3 现货
有超大折扣

今日订购,明日送达,全国免运费!

全国免费电话:400-668-6834   |   Email:info@selleck.cn

客户使用Selleck生产的Alisertib (MLN8237)发表文献235篇:

产品安全说明书

Aurora Kinase抑制剂选择性比较

生物活性

产品描述 Alisertib (MLN8237)是一种选择性Aurora A抑制剂,无细胞试验中IC50为1.2 nM,作用于Aurora A比作用于Aurora B选择性强200倍以上。Alisertib 可诱导细胞周期阻滞、细胞凋亡与自噬。Phase 3。
特性 MLN8237 是第一个口服有效的小分子Aurora A激酶选择性抑制剂。
靶点
Aurora A [1]
(Cell-free assay)
1.2 nM
体外研究

MLN8237作用于Aurora A选择性比作用于结构相关的Aurora B 高200多倍,IC50为396.5 nM, 而对205种其他激酶则没有显著活性。[1] 0.5 μM MLN8237处理MM1.S和 OPM1 细胞,抑制 Aurora A磷酸化,而不影响 Aurora B调节的组蛋白H3磷酸化。MLN8237作用于多发性骨髓瘤(MM) 细胞系,显著抑制细胞增殖,IC50为0.003-1.71 μM。在BM 基质细胞,IL-6和 IGF-1 存在时,MLN8237作用于原代MM 细胞和MM细胞系,抗增殖活性比只有MLN8237单独作用时高很多。0.5 μM MLN8237 作用于原代MM细胞和细胞系,使G2/M 期细胞提高2到6倍,且显著诱导凋亡和衰老,涉及p53, p21 和p27的上调,及 PARP,caspase 3,和 caspase 9的裂解。此外, MLN8237和 Dexamethasone联用具有协同作用,具有强抗MM 功效, 而和Doxorubicin 及Bortezomib联用则具有另外的功能。[2] 0.5 μM MLN8237处理 FLO-1, OE19, 和OE33 食管腺癌细胞系,抑制集落形成,且显著提高多倍体细胞百分数,随后提高G1期细胞百分数,而与 Cisplatin (2.5 μM)联用则效果进一步提高,与单独用药相比,诱导产生更多, TAp73β, PUMA, NOXA, cleaved caspase-3, 和cleaved PARP。[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HCT116 NIXJfVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkG5NE42KM7:TR?= NWPrSHFIPzJiaB?= MVLEUXNQ NFXFZ2xKSzVyPUCuNFQh|ryP Mn7IQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzM{[2PFQoRjJ4MUO2Olg1RC:jPh?=
LS174T MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHHNE42KM7:TR?= NXzI[npmPzJiaB?= M1XKRmROW09? NU\oU5pzUUN3ME2wMlA2KM7:TR?= MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF|Nk[4OEc,OjZzM{[2PFQ9N2F-
T84 NYjjZo1ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLHNE42KM7:TR?= M{C5WVczKGh? Mki3SG1UVw>? MXTJR|UxRTBwMEmg{txO NGjrRYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkGzOlY5PCd-Mk[xN|Y3QDR:L3G+
LS180 NFnocWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnSzNE42KM7:TR?= MlrEO|IhcA>? MVrEUXNQ MkXsTWM2OD1zIN88US=> MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF|Nk[4OEc,OjZzM{[2PFQ9N2F-
SW948 NX3xd4FRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYWwMlUh|ryP MmOzO|IhcA>? NFTKd|lFVVOR M1PWcGlEPTB;MTFOwG0> MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF|Nk[4OEc,OjZzM{[2PFQ9N2F-
HCT15 M1q1SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;tO5NNOC53IN88US=> M1PxcVczKGh? NH2zWXlFVVOR MlLJTWM2ODxyLkSg{txO NEXwNoQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkGzOlY5PCd-Mk[xN|Y3QDR:L3G+
DLD-1 MlXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPwdmUxNjVizszN NHjURmY4OiCq M2W4UmROW09? MV\JR|UxRDBwODFOwG0> NHSwfJg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkGzOlY5PCd-Mk[xN|Y3QDR:L3G+
MIP-101 NF\1dFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUThO3RCOC53IN88US=> NFy3N444OiCq NIC1ZZFFVVOR M4fifGlEPTB;MTFOwG0> M4jLdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MUO2Olg1Lz5{NkGzOlY5PDxxYU6=
SNU1544 NHziS4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vZUlAvPSEQvF2= NGrCfGw4OiCq Mn20SG1UVw>? Ml3yTWM2OD1zIN88US=> M1rQNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MUO2Olg1Lz5{NkGzOlY5PDxxYU6=
OCI-Ly10 M2ruTWN6fG:2b4jpZ{BCe3OjeR?= MXK3NkBp M1\hWWROW09? NWXlPWZ7UUN3ME2wMlA2QCEQvF2= MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh5OEOzNUc,OjV6N{izN|E9N2F-
SU-DHL2 MXPDfZRwfG:6aXOgRZN{[Xl? MnrFO|IhcA>? Mk\QSG1UVw>? MVrJR|UxRTBwMEGg{txO MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh5OEOzNUc,OjV6N{izN|E9N2F-
OCI-LY7 MVPDfZRwfG:6aXOgRZN{[Xl? M4XqSFczKGh? MlTPSG1UVw>? NXyyenRQUUN3ME2wMlA5OSEQvF2= M1;E[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEe4N|MyLz5{NUi3PFM{OTxxYU6=
SU-DHL6 MlrsR5l1d3SxeHnjJGF{e2G7 NFjmZYw4OiCq MVrEUXNQ MXTJR|UxRTBwNEiyJO69VQ>? M4jmOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEe4N|MyLz5{NUi3PFM{OTxxYU6=
Jeko-1 NXqxdVVPS3m2b4TvfIlkKEG|c3H5 MVq3NkBp NFnPOYhFVVOR NISz[2JKSzVyPUCuNFI6KM7:TR?= NX\KNmdERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4O|g{OzFpPkK1PFc5OzNzPD;hQi=>
JVM-2 NX35[IUzS3m2b4TvfIlkKEG|c3H5 NXHDU2NzPzJiaB?= NXfVWGFqTE2VTx?= NVO1eYJyUUN3ME2wMlAyKM7:TR?= NUnmTXF1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4O|g{OzFpPkK1PFc5OzNzPD;hQi=>
Rec-1 NHfENW9EgXSxdH;4bYMhSXO|YYm= M1j3SVczKGh? NXnJe|R5TE2VTx?= MWDJR|UxRTBwMEi3JO69VQ>? M{TsblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEe4N|MyLz5{NUi3PFM{OTxxYU6=
Z-138 NX7semUzS3m2b4TvfIlkKEG|c3H5 MUG3NkBp MX3EUXNQ NHviOGxKSzVyPUCuNFE{KM7:TR?= MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh5OEOzNUc,OjV6N{izN|E9N2F-
H9 MUXDfZRwfG:6aXOgRZN{[Xl? NF\oTYU4OiCq NIjqNGRFVVOR NFLXWldKSzVyPUCuOkDPxE1? MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh5OEOzNUc,OjV6N{izN|E9N2F-
HH NWDmc3Z{S3m2b4TvfIlkKEG|c3H5 M3\4V|czKGh? MoK3SG1UVw>? M{T1fWlEPTB;MD63JO69VQ>? NULkR4dxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4O|g{OzFpPkK1PFc5OzNzPD;hQi=>
DND41 Mk\JR5l1d3SxeHnjJGF{e2G7 MmflO|IhcA>? MonQSG1UVw>? NWXlZY1MUUN3ME2wMlEh|ryP NF3rW2I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi3PFM{OSd-MkW4O|g{OzF:L3G+
CCL119 NYDFU4tUS3m2b4TvfIlkKEG|c3H5 MYG3NkBp NGLPdJFFVVOR MWPJR|UxRTBwME[yJO69VQ>? M4XyTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEe4N|MyLz5{NUi3PFM{OTxxYU6=
J.Cam 1.6 MmXRR5l1d3SxeHnjJGF{e2G7 M1nrSlczKGh? MmT6SG1UVw>? MWXJR|UxRTBwMUC1JO69VQ>? MnLxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6N{izN|EoRjJ3OEe4N|MyRC:jPh?=
Sup-T1 MXLDfZRwfG:6aXOgRZN{[Xl? MXK3NkBp NXLueW5iTE2VTx?= NYDMTpVbUUN3ME2yMlE1OiEQvF2= NIjhTZU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi3PFM{OSd-MkW4O|g{OzF:L3G+
Tib 152 MXLDfZRwfG:6aXOgRZN{[Xl? M1GyWlczKGh? MlG4SG1UVw>? MWrJR|UxRTBwODFOwG0> M3ruPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEe4N|MyLz5{NUi3PFM{OTxxYU6=
MCF7 M{mzOWZ2dmO2aX;uJGF{e2G7 NGDoVYU2KM7:TR?= NH7sO3AzPCCq NI\6[IhFVVOR NYXLPVRzUW6mdXPld{BIOi:PIHHydoV{fA>? MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh|NESwNUc,OjV6M{S0NFE9N2F-
MDA-MB-231 MlvsSpVv[3Srb36gRZN{[Xl? M3\ZPFUh|ryP NH;hOGQzPCCq MUjEUXNQ NEH5bG5KdmS3Y3XzJGc{N01iYYLy[ZN1 NHv0bmg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUizOFQxOSd-MkW4N|Q1ODF:L3G+
MCF7 NXP4WGRGTnWwY4Tpc44hSXO|YYm= NX3CeG9UPSEQvF2= MofSNlQhcA>? MVXEUXNQ NVyxRpdDTGWlcnXhd4V{KHSqZTDlfJBz\XO|aX;uJIxmfmWuIH;mJGNFUzFxQ1TDNi=> MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh|NESwNUc,OjV6M{S0NFE9N2F-
MCF7 MXPGeY5kfGmxbjDBd5NigQ>? NWHL[pBuPSEQvF2= NFexVpAzPCCq NY\Fb|BQTE2VTx?= M1PrSWRm[3KnYYPld{B1cGViZYjwdoV{e2mxbjDs[ZZmdCCxZjDDSGsz MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh|NESwNUc,OjV6M{S0NFE9N2F-
MCF7 NIX0S45HfW6ldHnvckBCe3OjeR?= MUi1JO69VQ>? NUn4W|REOjRiaB?= Mo\KSG1UVw>? MVTE[YNz\WG|ZYOgeIhmKGW6cILld5Nqd25ibHX2[Ywhd2ZiY4njcIlvKEJz M2LGVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEO0OFAyLz5{NUizOFQxOTxxYU6=
MCF7 NUjXVpQxTnWwY4Tpc44hSXO|YYm= NH;wXWU2KM7:TR?= M4D6ZVI1KGh? M1XGVWROW09? M3vQdGlv[3KnYYPld{B1cGViZYjwdoV{e2mxbjDs[ZZmdCCxZjDwNlEhX2GoMT;DbZAy Ml3YQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6M{S0NFEoRjJ3OEO0OFAyRC:jPh?=
MCF7 NVfmSnBkTnWwY4Tpc44hSXO|YYm= NEPrUY42KM7:TR?= NUDlXVZxOjRiaB?= NF32dXVFVVOR MV7JcoNz\WG|ZYOgeIhmKGW6cILld5Nqd25ibHX2[Ywhd2ZicEK3JGtqeDF? NWn4TZRlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4N|Q1ODFpPkK1PFM1PDBzPD;hQi=>
MDA-MB-231 Mnj2SpVv[3Srb36gRZN{[Xl? MWe1JO69VQ>? NX\4b4E6OjRiaB?= NX7IUpRXTE2VTx?= MVfE[YNz\WG|ZYOgeIhmKGW6cILld5Nqd25ibHX2[Ywhd2ZiQ1TLNU9ETEN{ NHjpb|c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUizOFQxOSd-MkW4N|Q1ODF:L3G+
MDA-MB-231 MWHGeY5kfGmxbjDBd5NigQ>? MWqxJO69VQ>? NXfue2hxOjRiaB?= M{TXN2ROW09? MkXFTY5kemWjc3XzJJRp\SCneIDy[ZN{cW:wIHzleoVtKG:oIFPET|I> NVPUS5p3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4N|Q1ODFpPkK1PFM1PDBzPD;hQi=>
MDA-MB-231 MY\GeY5kfGmxbjDBd5NigQ>? NHn6WYU2KM7:TR?= M1S2UlI1KGh? NYfvNlRJTE2VTx?= M3TQNGRm[3KnYYPld{B1cGViZYjwdoV{e2mxbjDs[ZZmdCCxZjDjfYNtcW5iQkG= M1zmTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEO0OFAyLz5{NUizOFQxOTxxYU6=
MDA-MB-231 MmWzSpVv[3Srb36gRZN{[Xl? M3zWS|Uh|ryP MoLmNlQhcA>? NUDSWnJQTE2VTx?= M{LzSmlv[3KnYYPld{B1cGViZYjwdoV{e2mxbjDs[ZZmdCCxZjDwNlEhX2GoMT;DbZAy MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh|NESwNUc,OjV6M{S0NFE9N2F-
MDA-MB-231 MUPGeY5kfGmxbjDBd5NigQ>? NEHLT|Y2KM7:TR?= NWDqV4JMOjRiaB?= NIrEO3VFVVOR NHfzO|hKdmO{ZXHz[ZMhfGinIHX4dJJme3Orb36gcIV3\Wxib3[gdFI4KEurcEG= MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh|NESwNUc,OjV6M{S0NFE9N2F-
MDA-MB-231 M1nMZ2Z2dmO2aX;uJGF{e2G7 NIjLN2g2KM7:TR?= NIP5cHczPCCq MnPmSG1UVw>? Moq2TY5kemWjc3XzJJRp\SCneIDy[ZN{cW:wIHzleoVtKG:oIIC1Ny=> NXjnc|N[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4N|Q1ODFpPkK1PFM1PDBzPD;hQi=>
MCF7 NGWzUINCeG:ydH;zbZMhSXO|YYm= MnvyOUDPxE1? NEjL[|kzPCCq NH7GV21FVVOR Ml;WTY5lfWOnczDhdI9xfG:2aXOg[IVifGh? M1O3eVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEO0OFAyLz5{NUizOFQxOTxxYU6=
MDA-MB-231 NFnFZplCeG:ydH;zbZMhSXO|YYm= MUC1JO69VQ>? M2XqTlI1KGh? MWDEUXNQ NEfmPJFKdmS3Y3XzJIFxd3C2b4TpZ{Bl\WG2aB?= NHftVVM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUizOFQxOSd-MkW4N|Q1ODF:L3G+
MCF7 NVrZdJBoTnWwY4Tpc44hSXO|YYm= NUn5XVJoOSEQvF2= NEWzPYI4OiCq NFz6R|ZFVVOR NXjOXIREUW6mdXPld{BifXSxcHjh[4lkKGSnYYTo NHrKeVM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUizOFQxOSd-MkW4N|Q1ODF:L3G+
MDA-MB-231 MmGzSpVv[3Srb36gRZN{[Xl? NIHOXoQyKM7:TR?= NWXrfIlPPzJiaB?= NHraWmVFVVOR NHywT|VKdmS3Y3XzJIF2fG:yaHHnbYMh\GWjdHi= NGjRfoY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUizOFQxOSd-MkW4N|Q1ODF:L3G+
U-2 OS MnjWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWO1NEDPxE1? MYGyOEBp M3f6fmROW09? MlfaTWM2OD1zNj62JO69VQ>? MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd7MkixNUc,OjV5OUK4NVE9N2F-
MG-63 MoTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTPSZh[PTBizszN MYKyOEBp M12zO2ROW09? NGLaW25KSzVyPUmuOUDPxE1? NGjtfWw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe5NlgyOSd-MkW3PVI5OTF:L3G+
U-2 OS MlPVRZBweHSxc3nzJGF{e2G7 M3fseFUh|ryP NFnPPFczPCCq M2\Zb2ROW09? MkX6TY5lfWOnczDhdI9xfG:2aXOgZ4VtdCCmZXH0bC=> MlPzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5OUK4NVEoRjJ3N{myPFEyRC:jPh?=
MG-63 M4e2e2Fxd3C2b4Ppd{BCe3OjeR?= NYLJNHN5PSEQvF2= NWrLfm5pOjRiaB?= Mm[xSG1UVw>? NWL3UFBVUW6mdXPld{BieG:ydH;0bYMh[2WubDDk[YF1cA>? NI\GXoc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe5NlgyOSd-MkW3PVI5OTF:L3G+
U-2 OS NHW0PG5HfW6ldHnvckBCe3OjeR?= NVPlUmM1PSEQvF2= NULwfHd6OjRiaB?= M3i0ZmROW09? MkPPVJJwdW:2ZYOgZZV1d3CqYXfpZ{Bk\WyuIHTlZZRp NF[3UIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe5NlgyOSd-MkW3PVI5OTF:L3G+
MG-63 NEjKTllHfW6ldHnvckBCe3OjeR?= NFX0SpI2KM7:TR?= Mm[0NlQhcA>? Ml62SG1UVw>? MUjQdo9ud3SnczDheZRweGijZ3njJINmdGxiZHXheIg> M{Lq[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{myPFEyLz5{NUe5NlgyOTxxYU6=
PANC-1 M1fLRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPXOVAh|ryP Mn3vNlQhcA>? MXTEUXNQ NVrEdHQzUUN3ME23MlEh|ryP MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ|MkKyOUc,OjV4M{KyNlU9N2F-
BxPC-3 M3nzUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWm1NEDPxE1? NFLPdJczPCCq NUjPfYNzTE2VTx?= M1TvR2lEPTB;Nj64JO69VQ>? M{e5UlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkOyNlI2Lz5{NU[zNlIzPTxxYU6=
PANC-1 MXXGeY5kfGmxbjDBd5NigQ>? Mn\LOUDPxE1? MV[yOEBp M3\BZWROW09? M3zLfWlv\HWlZYOgZ4VtdCCleXPs[UBienKnc4SgbY4hTzJxTTDwbIF{\Q>? M{n2cVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkOyNlI2Lz5{NU[zNlIzPTxxYU6=
BxPC-3 NYfPdodRTnWwY4Tpc44hSXO|YYm= M2i1eVUh|ryP NU\4SJNHOjRiaB?= NEe4OYVFVVOR MorETY5lfWOnczDj[YxtKGO7Y3zlJIFzemW|dDDpckBIOi:PIIDoZZNm M3ywd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkOyNlI2Lz5{NU[zNlIzPTxxYU6=
PANC-1 MYTGeY5kfGmxbjDBd5NigQ>? MXW1JO69VQ>? NVTjT4tXOjRiaB?= NWP3O4x4TE2VTx?= M4nkSGlv\HWlZYOgZZV1d3CqYXfpZ{Bk\WyuIHTlZZRp NIPMN5U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[zNlIzPSd-MkW2N|IzOjV:L3G+
BxPC-3 NWT5T3ZHTnWwY4Tpc44hSXO|YYm= M3nrO|Uh|ryP MnzQNlQhcA>? NEjIRXhFVVOR M3rSbWlv\HWlZYOgZZV1d3CqYXfpZ{Bk\WyuIHTlZZRp M2jKdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkOyNlI2Lz5{NU[zNlIzPTxxYU6=
SKOV3 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLSV|d4OTByIN88US=> NXj4UpRwOjRiaB?= MnjXSG1UVw>? NH;UZ|VKSzVyPUKwMlQ5KM7:TR?= MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ{NEe1NEc,OjV4MkS3OVA9N2F-
OVCAR4 NFTkO4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnSXZNjOTByIN88US=> Mn76NlQhcA>? Ml62SG1UVw>? MUDJR|UxRTJ{LkGzJO69VQ>? MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ{NEe1NEc,OjV4MkS3OVA9N2F-
SKOV3 NVL1SFJ7TnWwY4Tpc44hSXO|YYm= M3TFRVUh|ryP NVzFXnVGPzJiaB?= NV\IVoVZTE2VTx?= NFrTUYNKdmS3Y3XzJGczN01iYYLy[ZN1 NX[5UFZDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2NlQ4PTBpPkK1OlI1PzVyPD;hQi=>
OVCAR4 M3e5TWZ2dmO2aX;uJGF{e2G7 MnmzOUDPxE1? MXy3NkBp NX3qS2c6TE2VTx?= Ml\rTY5lfWOnczDHNk9OKGG{cnXzeC=> NIfQPZE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[yOFc2OCd-MkW2NlQ4PTB:L3G+
SKOV3 M4jLPWFxd3C2b4Ppd{BCe3OjeR?= NETLWHU2KM7:TR?= NHSwTpozPCCq NVnNWmZlTE2VTx?= MXTJcoR2[2W|IHHwc5B1d3Orcx?= M4HoeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkK0O|UxLz5{NU[yOFc2ODxxYU6=
OVCAR4 MYjBdI9xfG:|aYOgRZN{[Xl? MWe1JO69VQ>? Mlz4NlQhcA>? Ml\nSG1UVw>? NXG2e3NvUW6mdXPld{BieG:ydH;zbZM> NYHXN4hFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2NlQ4PTBpPkK1OlI1PzVyPD;hQi=>
AGS M1qwXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUT5XpN7OjVizszN MV[yOEBp MXvEUXNQ MmDRTWM2OD1zOT6wPUDPxE1? MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZyOUmyN{c,OjV4MEm5NlM9N2F-
NCI-N78 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYiyOUDPxE1? Mn2zNlQhcA>? NEDz[m1FVVOR NUf0V4VFUUN3ME2yOk4{OyEQvF2= MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZyOUmyN{c,OjV4MEm5NlM9N2F-
AGS M1z2fmFxd3C2b4Ppd{BCe3OjeR?= MUm1JO69VQ>? MX[yOEBp MVPEUXNQ MY\JcoR2[2W|IHHwc5B1d3Orcx?= NEftbFY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[wPVkzOyd-MkW2NFk6OjN:L3G+
NCI-N78 NXroNYJXSXCxcITvd4l{KEG|c3H5 Mn;OOUDPxE1? MlLiNlQhcA>? M2XqOWROW09? MWrJcoR2[2W|IHHwc5B1d3Orcx?= NUXXbVhWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2NFk6OjNpPkK1OlA6QTJ|PD;hQi=>
AGS MU\GeY5kfGmxbjDBd5NigQ>? M1TNTVUh|ryP M2rue|I1KGh? NFPkSmZFVVOR MnPVTY5lfWOnczD0bIUh[XW2b4DoZYd6 MmHJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4MEm5NlMoRjJ3NkC5PVI{RC:jPh?=
NCI-N78 MXTGeY5kfGmxbjDBd5NigQ>? NWrUUYs{PSEQvF2= M1\nOFI1KGh? NFXVOGpFVVOR M4LGUGlv\HWlZYOgeIhmKGG3dH;wbIFogQ>? NF7Fe3k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[wPVkzOyd-MkW2NFk6OjN:L3G+
HSC-3 NIq0bWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1iyfVEh|ryP MoS5OFghcA>? NG\Ic2lKSzVyPUCuOVQh|ryP NYHmVXpqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWzOlYyPDNpPkK1N|Y3OTR|PD;hQi=>
GB30 NF\LXldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2[0SlEh|ryP MnG1O{Bl MX\EUXNQ NVfmVJk2UUN3ME2wMlAyOSEQvF2= MoXHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVzME[0NlgoRjJ3MUC2OFI5RC:jPh?=
GB9 NHzFVIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\ueJAyKM7:TR?= MV63JIQ> NX\KXG5rTE2VTx?= NXrlbopFUUN3ME2wMlAzPCEQvF2= Mmf0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVzME[0NlgoRjJ3MUC2OFI5RC:jPh?=
GB169 NHjPXG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYX3N4tmOSEQvF2= Mm\XO{Bl MYrEUXNQ MV\JR|UxRTBwMEOyJO69VQ>? Ml\MQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVzME[0NlgoRjJ3MUC2OFI5RC:jPh?=
T24 MXnGeY5kfGmxbjDBd5NigQ>? NX\2UFg4OSEQvF2= M3fzR|Q5KGh? NIfYeJBFVVOR MWnJcoR2[2W|IHPlcIwh[3mlbHWgZZJz\XO2 NHXK[ZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{SwN|Y{Oyd-MkO0NFM3OzN:L3G+
RT4 MYTGeY5kfGmxbjDBd5NigQ>? NFq4c3oyKM7:TR?= M1zBe|Q5KGh? M{P6PWROW09? NET3NHVKdmS3Y3XzJINmdGxiY4njcIUh[XK{ZYP0 MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzRyM{[zN{c,OjN2MEO2N|M9N2F-
UM-UC-3 M1;DemZ2dmO2aX;uJGF{e2G7 MXSxJO69VQ>? Mnv6OFghcA>? NHvHRmxFVVOR MUDJcoR2[2W|IHPlcIwh[3mlbHWgZZJz\XO2 MnfLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2MEO2N|MoRjJ|NECzOlM{RC:jPh?=
T24 NWXjfGV5SXCxcITvd4l{KEG|c3H5 MoXTN{4yPiEQvF2= MonHPVYhcA>? M2n5TmROW09? NIex[3RKSzVyPUCuNFMxPiEQvF2= NUP4ZnBIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0NFM3OzNpPkKzOFA{PjN|PD;hQi=>
RT4 MV3BdI9xfG:|aYOgRZN{[Xl? Ml;DN{4yPiEQvF2= MlrLPVYhcA>? MUPEUXNQ MmW5TWM2OD1yLkGxPVgh|ryP M3Tl[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NECzOlM{Lz5{M{SwN|Y{OzxxYU6=
UM-UC-3 NGX2ephCeG:ydH;zbZMhSXO|YYm= MmLEN{4yPiEQvF2= NH3EN3o6PiCq MWfEUXNQ NETG[41KSzVyPUCuNFQ1QSEQvF2= NVm0UG5wRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0NFM3OzNpPkKzOFA{PjN|PD;hQi=>
OVCAR-5 M2LUbmZ2dmO2aX;uJGF{e2G7 MUW1NEBvVQ>? MVHJcohq[mm2czDj[YxtKG2rZ4LheIlwdg>? NWrIbFU5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzN|Q{OjdpPkKzN|M1OzJ5PD;hQi=>
SKOV3ip2 M1XJO2Z2dmO2aX;uJGF{e2G7 M4i2[|UxKG6P M{nHWWlvcGmkaYTzJINmdGxibXnndoF1cW:w MkLsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|M{SzNlcoRjJ|M{O0N|I4RC:jPh?=
S462 NF7lVm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUKxNFAh|ryP MUe3NkBp NUHvT4pETE2VTx?= NH7ZephCfHSnboXheIV{KGOnbHyg[5Jwf3Sq MnrMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MkixNVQoRjJ|M{K4NVE1RC:jPh?=
2884 M2LiOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TXT|ExOCEQvF2= NGLGU4I4OiCq MnfCSG1UVw>? M{\0O2F1fGWwdXH0[ZMh[2WubDDndo94fGh? M1LM[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{K4NVE1Lz5{M{OyPFEyPDxxYU6=
2885 MmjpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;ONVAxKM7:TR?= NWPDUnlTPzJiaB?= Ml;wSG1UVw>? M3\yemF1fGWwdXH0[ZMh[2WubDDndo94fGh? M3W3elxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{K4NVE1Lz5{M{OyPFEyPDxxYU6=
CRL-2396 MnTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHTN5p2OTByIN88US=> Mmn4e4F1\XJ? NUnDPG1lUUN3ME2wMlA6OiEQvF2= MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzF3M{WyOEc,OjNzNUO1NlQ9N2F-
TIB-48 MofqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPyNVAxKM7:TR?= M4rS[5difGW{ NFj5XHNKSzVyPUCuNFg5KM7:TR?= NVjOUYFVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOxOVM2OjRpPkKzNVU{PTJ2PD;hQi=>
CRL-2396 NH7kenNEgXSxdH;4bYMhSXO|YYm= NVy4R|d5OSEQvF2= M4n5VFQ5KGh? MW\3ZZRmeg>? NHLqT3hKdmS3Y3XzJIFxd3C2b4Ppdy=> MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzF3M{WyOEc,OjNzNUO1NlQ9N2F-
TIB-48 NETzWo9EgXSxdH;4bYMhSXO|YYm= NHfiVHcyKM7:TR?= MmLoOFghcA>? MVX3ZZRmeg>? M{nvUmlv\HWlZYOgZZBweHSxc3nz NVjDVo1ORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOxOVM2OjRpPkKzNVU{PTJ2PD;hQi=>
AGS NILrXYVEgXSxdH;4bYMhSXO|YYm= MVGwMlUh|ryP M1u1PVI1KGh? MUDEUXNQ M1nzOGRm[3KnYYPld{Bk\WyuIIP1dpZqfmGu NILQRlg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mkm3NlYyOSd-MkK5O|I3OTF:L3G+
FLO-1 NWrqXGQ5S3m2b4TvfIlkKEG|c3H5 Mn\BNE42KM7:TR?= MXuyOEBp NGLGNYdFVVOR MmTsSIVkemWjc3XzJINmdGxic4Xyeol3[Wx? MmD1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ7N{K2NVEoRjJ{OUeyOlEyRC:jPh?=
OE33 NF3RSolEgXSxdH;4bYMhSXO|YYm= MWiwMlUh|ryP Mk\LNlQhcA>? NHXMSlJFVVOR NY\LVlFTTGWlcnXhd4V{KGOnbHygd5Vzfmm4YXy= MlrtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ7N{K2NVEoRjJ{OUeyOlEyRC:jPh?=
SKLMS MYfDfZRwfG:6aXOgRZN{[Xl? MYS3OUBvVQ>? NInKPI06PiCq NVO4SYdqUW6mdXPld{BieG:ydH;zbZM> M2TTblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OEKxPVk4Lz5{MkiyNVk6PzxxYU6=
Leio285 NUPuZXVrS3m2b4TvfIlkKEG|c3H5 Ml7pO|Uhdk1? NXLNUpBuQTZiaB?= M2TwU2lv\HWlZYOgZZBweHSxc3nz MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh{MUm5O{c,OjJ6MkG5PVc9N2F-
Mes-Sa NWfvcoV5S3m2b4TvfIlkKEG|c3H5 MWK3OUBvVQ>? MnHIPVYhcA>? NVvVSVNSUW6mdXPld{BieG:ydH;zbZM> MoryQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6MkG5PVcoRjJ{OEKxPVk4RC:jPh?=
DAOY M2LhPWN6fG:2b4jpZ{BCe3OjeR?= NX7sb4w1OTBizszN NIjHO|c4OiCq NX\ISlAxTE2VTx?= NYLNPHIxUUN3ME2wMlA1KM7:TR?= NHPIUW49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mk[2PVM{PSd-MkK2Olk{OzV:L3G+
IMR32 MWTDfZRwfG:6aXOgRZN{[Xl? M3LkdVExKM7:TR?= MWq3NkBp MmnzSG1UVw>? M2O5OmlEPTB;MD6wN{DPxE1? NXnqWJc{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK2Olk{OzVpPkKyOlY6OzN3PD;hQi=>
Molt-4 NWD0[oZ6S3m2b4TvfIlkKEG|c3H5 M4\1d|ExKM7:TR?= NEG2PFk4OiCq NISzTGNFVVOR NX3OO2tyUUN3ME2wMlAzKM7:TR?= MlnxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ4NkmzN|UoRjJ{Nk[5N|M2RC:jPh?=
MOLM-13 M33KV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfvbmk4OyEQvF2= MmLnO|IhcA>? NEjTPYZFcW2rbnnzbIV{KGOnbHygeoli[mmuaYT5 NF7IZ2w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkS4PFI1QSd-MkK0PFgzPDl:L3G+
HL-60 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HrNFMh|ryP M2DDeVczKGh? NY\BToZZTGmvaX7pd4hmeyClZXzsJJZq[WKrbHn0fS=> NI[3OHY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkS4PFI1QSd-MkK0PFgzPDl:L3G+
MV4-11 M2\uOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHtTXJlOyEQvF2= M1rpRVczKGh? M{DwRWRqdWmwaYPo[ZMh[2WubDD2bYFjcWyrdIm= MnnVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2OEiyOFkoRjJ{NEi4NlQ6RC:jPh?=
SKM-1 M{noOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEj4bGI{KM7:TR?= MV23NkBp M{PDfmRqdWmwaYPo[ZMh[2WubDD2bYFjcWyrdIm= NVTydpV1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0PFgzPDlpPkKyOFg5OjR7PD;hQi=>
SH2 Mn3NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;6NVMh|ryP MUO3NkBp NWTMcFF3TGmvaX7pd4hmeyClZXzsJJZq[WKrbHn0fS=> M1r5W|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEi4NlQ6Lz5{MkS4PFI1QTxxYU6=
NOMO-1 MljZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfoSVZJOyEQvF2= NE\sSZA4OiCq M4nxPWRqdWmwaYPo[ZMh[2WubDD2bYFjcWyrdIm= MnG1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2OEiyOFkoRjJ{NEi4NlQ6RC:jPh?=
OCL-AML2 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVizJO69VQ>? M2TIZ|czKGh? NXnlTHJJTGmvaX7pd4hmeyClZXzsJJZq[WKrbHn0fS=> MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR6OEK0PUc,OjJ2OEiyOFk9N2F-
PL-21 NFTYZWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX63[5lQOyEQvF2= NVfKdlR4PzJiaB?= NVvFbnQzTGmvaX7pd4hmeyClZXzsJJZq[WKrbHn0fS=> NFPDXGQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkS4PFI1QSd-MkK0PFgzPDl:L3G+
KG-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HwPFMh|ryP M{nkN|czKGh? NXvRfJNZTGmvaX7pd4hmeyClZXzsJJZq[WKrbHn0fS=> NF\2UVg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkS4PFI1QSd-MkK0PFgzPDl:L3G+
A172 M3zndWN6fG:2b4jpZ{BCe3OjeR?= MWSxNFAh|ryP MX6yOEBp M3OzPWROW09? MVvJR|UxRTBwMUKwJO69VQ>? NELxNpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkK3OFM6QSd-MkKyO|Q{QTl:L3G+
U87 MV\DfZRwfG:6aXOgRZN{[Xl? MnzFNVAxKM7:TR?= NFOwSHczPCCq NEO4TnhFVVOR NHjqUmdKSzVyPUCuNVA2KM7:TR?= M4G1OlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{Mke0N|k6Lz5{MkK3OFM6QTxxYU6=
U251 NFfV[mJEgXSxdH;4bYMhSXO|YYm= NXH2S5FSOTByIN88US=> M{jFb|I1KGh? NV3Ye5FsTE2VTx?= MnPTTWM2OD1yLkGwNEDPxE1? NUC1ZWNCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyO|Q{QTlpPkKyNlc1Ozl7PD;hQi=>
T98 NV3ieWtzS3m2b4TvfIlkKEG|c3H5 NW\XdJp7OTByIN88US=> MX[yOEBp NHnOeIJFVVOR Mlz2TWM2OD1yLkGyOUDPxE1? NVTHWm1MRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyO|Q{QTlpPkKyNlc1Ozl7PD;hQi=>
LN18 MkXsR5l1d3SxeHnjJGF{e2G7 NUjZNVJiOTByIN88US=> MkDoNlQhcA>? MXnEUXNQ NFvBdXZKSzVyPUCuNlExKM7:TR?= M1HsclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{Mke0N|k6Lz5{MkK3OFM6QTxxYU6=
LN443 MYrDfZRwfG:6aXOgRZN{[Xl? NHvCN4MyODBizszN NH2wflEzPCCq NYSyN45jTE2VTx?= NXHHWWw6UUN3ME2wMlIzOCEQvF2= NYO5SXRORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyO|Q{QTlpPkKyNlc1Ozl7PD;hQi=>
HF66 M{m4VGN6fG:2b4jpZ{BCe3OjeR?= M2[2OlExOCEQvF2= MUKyOEBp MljSSG1UVw>? M4L3V2lEPTB;MD6yNlUh|ryP MoLkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{N{SzPVkoRjJ{Mke0N|k6RC:jPh?=
HF2303 NYnQN2FnS3m2b4TvfIlkKEG|c3H5 MV[xNFAh|ryP M2jsW|I1KGh? NHLBUIVFVVOR NGLaV2dKSzVyPUCuNFYxKM7:TR?= MkLoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{N{SzPVkoRjJ{Mke0N|k6RC:jPh?=
HF2359 NXn3XlFIS3m2b4TvfIlkKEG|c3H5 M133R|ExOCEQvF2= NGi0dowzPCCq M1XHV2ROW09? MX;JR|UxRTBwME[wJO69VQ>? NH7ZcWk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkK3OFM6QSd-MkKyO|Q{QTl:L3G+
HF2414 NF\PbIJEgXSxdH;4bYMhSXO|YYm= Mon3NVAxKM7:TR?= M2jhUFI1KGh? NUD5NJJlTE2VTx?= NXfYTIpjUUN3ME2wMlA5OCEQvF2= NUXzdpprRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyO|Q{QTlpPkKyNlc1Ozl7PD;hQi=>
A-673 NFLTUGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn[4NVAh|ryP MXS5OkBp MnHISG1UVw>? MVHJR|UxRTBwMEOyJO69VQ>? M{DM[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNES4OVkyLz5{MUS0PFU6OTxxYU6=
TC-32 M3\1Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLLZZRFOTBizszN NHjTUWk6PiCq MUnEUXNQ M4TOSmlEPTB;MD6wN|kh|ryP Mn;yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2NEi1PVEoRjJzNES4OVkyRC:jPh?=
TC-71 NXjuXYRUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPIR2kyOCEQvF2= MWq5OkBp NF7UPXdFVVOR NWDxOXpZUUN3ME2wMlExOiEQvF2= M4DpVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNES4OVkyLz5{MUS0PFU6OTxxYU6=
SK-N-MC MkftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\ndG41OTBizszN M4LJWlk3KGh? NXHjOFFrTE2VTx?= NIPCTFVKSzVyPUCuNFczKM7:TR?= MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTR2OEW5NUc,OjF2NEi1PVE9N2F-
CHLA-9 M4LFcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXft[GZmOTBizszN NWH6b5AzQTZiaB?= MX7EUXNQ M4XCc2lEPTB;MD6wNVgh|ryP NUTUcYxXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0OFg2QTFpPkKxOFQ5PTlzPD;hQi=>
CHLA-10 NXTWdW9kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLWNVAh|ryP NULWcXpHQTZiaB?= NWX3TJpSTE2VTx?= MYPJR|UxRTBwME[wJO69VQ>? M1LtTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNES4OVkyLz5{MUS0PFU6OTxxYU6=
CHLA-25 NWTPOHNwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\yN4oyOCEQvF2= NWHrVGtXQTZiaB?= MX3EUXNQ M4S1N2lEPTB;MD6xOlgh|ryP MoHDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2NEi1PVEoRjJzNES4OVkyRC:jPh?=
CHLA-32 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYmxNEDPxE1? NGfpVW86PiCq M{D2UWROW09? NIPYRYZKSzVyPUCuNVM3KM7:TR?= NUDUcG1QRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0OFg2QTFpPkKxOFQ5PTlzPD;hQi=>
CHLA-56 NYC0PIFbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYmxNEDPxE1? MkLFPVYhcA>? NYH2VGpVTE2VTx?= NWPsTVlCUUN3ME2xNEDPxE1? NW\FPGRHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0OFg2QTFpPkKxOFQ5PTlzPD;hQi=>
CHLA-258 M{XqRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLpNVAh|ryP M1;I[|k3KGh? NFP5NndFVVOR MoL6TWM2OD1yLkGzNkDPxE1? M1fsVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNES4OVkyLz5{MUS0PFU6OTxxYU6=
COG-E-352 NU\Wc29DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYixNEDPxE1? MVG5OkBp Mo\SSG1UVw>? MnnkTWM2OD1yLkC0N{DPxE1? Mln5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2NEi1PVEoRjJzNES4OVkyRC:jPh?=
CHLA-90 NVzsfotFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmexNVAh|ryP MYe5OkBp NYGzNHBVTE2VTx?= NFXHU|VKSzVyPUCuNFYyKM7:TR?= MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTR2OEW5NUc,OjF2NEi1PVE9N2F-
CHLA-119 NYjoR5ZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moi4NVAh|ryP MWK5OkBp NXvBXpRtTE2VTx?= NGH0c3BKSzVyPUCuNFIzKM7:TR?= NYqzW5VkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0OFg2QTFpPkKxOFQ5PTlzPD;hQi=>
CHLA-122 NGD0bVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3aUGRiOTBizszN M2TJXFk3KGh? NFXUcWVFVVOR NF:wO4lKSzVyPUCuNFE6KM7:TR?= NX3PcHFxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0OFg2QTFpPkKxOFQ5PTlzPD;hQi=>
CHLA-136 M4rwcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4P6TlExKM7:TR?= M2rvOVk3KGh? NGn5UXNFVVOR Mn:1TWM2OD1yLkCzPUDPxE1? MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTR2OEW5NUc,OjF2NEi1PVE9N2F-
CHLA-140 NXPCUngzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoKxNVAh|ryP NHL3UII6PiCq MW\EUXNQ MVzJR|UxRTBwMEK2JO69VQ>? M124cVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNES4OVkyLz5{MUS0PFU6OTxxYU6=
LA-N-6 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnLNHkyOCEQvF2= NVHwTpp3QTZiaB?= NHzLVoZFVVOR MVjJR|UxRTBwMEW0JO69VQ>? MoHJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2NEi1PVEoRjJzNES4OVkyRC:jPh?=
NB-1643 NF3zOJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYqxNEDPxE1? Mn7SPVYhcA>? M4rvVWROW09? MVzJR|UxRTBwMEO3JO69VQ>? M{PUelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNES4OVkyLz5{MUS0PFU6OTxxYU6=
NB-EBc1 NYHTb49QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2C0R|ExKM7:TR?= MmD6PVYhcA>? Ml3BSG1UVw>? NHTuZmVKSzVyPUCuNFUxKM7:TR?= NXH4[JBjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0OFg2QTFpPkKxOFQ5PTlzPD;hQi=>
SK-N-BE-1 MoC2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV[xNEDPxE1? NHjtVXY6PiCq NYTaVXZzTE2VTx?= NXzWXGxyUUN3ME2wMlAzQCEQvF2= M{i3ZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNES4OVkyLz5{MUS0PFU6OTxxYU6=
SK-N-BE-2 NHTGT5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWni[oNCOTBizszN NU[0RWtjQTZiaB?= NVrTTmNlTE2VTx?= MnnzTWM2OD1yLkCzOkDPxE1? NEe4OIc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUS0PFU6OSd-MkG0OFg2QTF:L3G+
SMS-KAN NEjjTYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYCxNEDPxE1? NETFd|Y6PiCq MWHEUXNQ Mo\lTWM2OD1yLkCzOEDPxE1? M3HGflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNES4OVkyLz5{MUS0PFU6OTxxYU6=
SMS-KANR NUD2VmVXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn:3NVAh|ryP NVzLVmFtQTZiaB?= NXL1VW0yTE2VTx?= MkXjTWM2OD1yLkCyOkDPxE1? NGrNd3U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUS0PFU6OSd-MkG0OFg2QTF:L3G+
SMS-KCN MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlWzNVAh|ryP MnS1PVYhcA>? MUPEUXNQ MmPGTWM2OD1yLkCxPUDPxE1? M2HGTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNES4OVkyLz5{MUS0PFU6OTxxYU6=
SMS-KCNR Mn3DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVmxNEDPxE1? NHrsSFA6PiCq NEn0cGZFVVOR MnXaTWM2OD1yLkCxNEDPxE1? NIDmbZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUS0PFU6OSd-MkG0OFg2QTF:L3G+
SMS-LHN NGXhRmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nYdVExKM7:TR?= M3PZSVk3KGh? Mlv1SG1UVw>? M3nqeGlEPTB;MD6wN|Ih|ryP M2\hb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNES4OVkyLz5{MUS0PFU6OTxxYU6=
SMS-MSN M{H4VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV:xNEDPxE1? NVzuZo45QTZiaB?= MU\EUXNQ MoSwTWM2OD1yLkCyNkDPxE1? NXHM[5BCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0OFg2QTFpPkKxOFQ5PTlzPD;hQi=>
SMS-SAN MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILSPYwyOCEQvF2= MUG5OkBp NXfYWmV4TE2VTx?= NVLBPIY3UUN3ME2wMlAzOCEQvF2= MlmyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2NEi1PVEoRjJzNES4OVkyRC:jPh?=
Granta-4 MVrDfZRwfG:6aXOgRZN{[Xl? NYTrVIRQOTBizszN MlLUO{Bl MkDDTWM2OD1yLkC0NEDPxE1? M{HM[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMkmxPFY4Lz5{MUK5NVg3PzxxYU6=
DB NVj2T2NXS3m2b4TvfIlkKEG|c3H5 M1W0W|ExKM7:TR?= MWi3JIQ> M4j6[mlEPTB;MD6wOFIh|ryP M4DJSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMkmxPFY4Lz5{MUK5NVg3PzxxYU6=
RL MXnDfZRwfG:6aXOgRZN{[Xl? M2jWe|ExKM7:TR?= NVPIT4o6PyCm NWDPb|k6UUN3ME2wMlAyPSEQvF2= NGLXfGM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUK5NVg3Pyd-MkGyPVE5Pjd:L3G+
K562 NFvBNINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUWyfpd3OTBizszN NH:3do86PiCq MU\JR|UxRTBwMEi3JO69VQ>? MojTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFyOUG2N|MoRjJzMEmxOlM{RC:jPh?=
LAMA-84 NYnpOFFGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWmxNEDPxE1? NGDROow6PiCq MW\JR|UxRTBwMEW3JO69VQ>? M3rnflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMEmxOlM{Lz5{MUC5NVY{OzxxYU6=
MM15 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXK0JO69VQ>? MYK3NkBp NHr4XZpFVVOR NH;MZlFKSzVyPUCuNVMh|ryP NYHjd2poRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzPFI5PDRpPkKwN|gzQDR2PD;hQi=>
OPM1 MmjES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\COEDPxE1? MVS3NkBp NGHYTZlFVVOR MnPhTWM2OD1yLkCzJO69VQ>? NX63bXpIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzPFI5PDRpPkKwN|gzQDR2PD;hQi=>
RPM1 NFe3OmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDzdY9wPCEQvF2= NX6wVGF3PzJiaB?= MXXEUXNQ NGDBSYRKSzVyPUGwMlMzKM7:TR?= MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODN6Mki0OEc,OjB|OEK4OFQ9N2F-
INA6 NEXkT|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYS0JO69VQ>? NWn3fVJUPzJiaB?= MVTEUXNQ NHXLbXRKSzVyPUCuNFAzKM7:TR?= NYHWTYVRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzPFI5PDRpPkKwN|gzQDR2PD;hQi=>
OPM2 NVuyNG5JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVW0JO69VQ>? NUnpdlN7PzJiaB?= NHn1WJhFVVOR MV\JR|UxRTRwM{eg{txO MnzSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB|OEK4OFQoRjJyM{iyPFQ1RC:jPh?=
MM1R NVXYc4xWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILTPWc1KM7:TR?= NHXKfYg4OiCq NUHnWGM4TE2VTx?= NVfIO|dUUUN3ME2xMlY5KM7:TR?= M{f5VVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{iyPFQ1Lz5{MEO4Nlg1PDxxYU6=
DOX40 MnjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfKOEDPxE1? NYfQRnozPzJiaB?= M3TY[WROW09? NUnZZ4ozUUN3ME21MlQ5KM7:TR?= MmH4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB|OEK4OFQoRjJyM{iyPFQ1RC:jPh?=
LR5 NX7IXlh{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{SxOFQh|ryP M{\XNFczKGh? MV3EUXNQ MkPlTWM2OD1{LkWzJO69VQ>? NWPBTJdRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzPFI5PDRpPkKwN|gzQDR2PD;hQi=>
U266 MoT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHBdIo1KM7:TR?= MkjmO|IhcA>? NEnOdpZFVVOR MorDTWM2OD1zLkSzJO69VQ>? MkXGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB|OEK4OFQoRjJyM{iyPFQ1RC:jPh?=
RD MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LzSlExKM7:TR?= MXe5OkBp NFvyWlVKSzVyPUCuNlI5KM7:TR?= MmfHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzMEizN|goRjJyMUC4N|M5RC:jPh?=
Rh41 NGf6[49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV2xNEDPxE1? NYXmeJllQTZiaB?= Ml7MTWM2OD1yLkC5NEDPxE1? M2rtblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUC4N|M5Lz5{MEGwPFM{QDxxYU6=
Rh30 M4W0[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFH5dWEyOCEQvF2= NFjteW86PiCq MWfJR|UxRTBwMkOwJO69VQ>? MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODFyOEOzPEc,OjBzMEizN|g9N2F-
BT-12 NFrRUJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\OZlIxOTBizszN NEXhb4E6PiCq M1vIUWlEPTB;MD6wOlAh|ryP MmjaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzMEizN|goRjJyMUC4N|M5RC:jPh?=
CHLA-266 M3vHNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHOb4RQOTBizszN MWO5OkBp M1PCfGlEPTB;MD6wO|Ih|ryP MlLxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzMEizN|goRjJyMUC4N|M5RC:jPh?=
TC-71 NYWyRmtZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnYNVAh|ryP NYTrdmJtQTZiaB?= M3HUTWlEPTB;MD6xNFIh|ryP NH[4TXY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEGwPFM{QCd-MkCxNFg{Ozh:L3G+
SJ-GBM2 NGfSOWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrQeYU1OTBizszN NVS1WJpJQTZiaB?= NEDQSmJKSzVyPUCuNFUxKM7:TR?= NHnEOYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEGwPFM{QCd-MkCxNFg{Ozh:L3G+
NALM-6 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jZUFExKM7:TR?= MV[5OkBp MofrTWM2OD1yLkC2NkDPxE1? M2qwVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUC4N|M5Lz5{MEGwPFM{QDxxYU6=
COG-LL-317 Ml\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFS0cYcyOCEQvF2= MXm5OkBp NFXqUG1KSzVyPUCuNFQ4KM7:TR?= MmT1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzMEizN|goRjJyMUC4N|M5RC:jPh?=
RS4-11 MnXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnQNVAh|ryP NFPmOHY6PiCq MVPJR|UxRTBwMEG4JO69VQ>? M{[zNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUC4N|M5Lz5{MEGwPFM{QDxxYU6=
MOLT-4 MmfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW[xNEDPxE1? NIrPbWw6PiCq MWHJR|UxRTBwMEK2JO69VQ>? MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODFyOEOzPEc,OjBzMEizN|g9N2F-
CCRF-CEM MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTvbHYyOCEQvF2= NULDN2FJQTZiaB?= NVHTRZhmUUN3ME2wMlA6PCEQvF2= Mn7nQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzMEizN|goRjJyMUC4N|M5RC:jPh?=
Kasumi-1 Mlu0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXz2b|R{OTBizszN MV25OkBp NEL1RnZKSzVyPUCuNVA{KM7:TR?= NIXlUHI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEGwPFM{QCd-MkCxNFg{Ozh:L3G+
Karpas-299 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInzOo0yOCEQvF2= MV[5OkBp MVnJR|UxRTBwMEO4JO69VQ>? MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODFyOEOzPEc,OjBzMEizN|g9N2F-
Ramos-RA1 M3rjWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPWTpQ3OTBizszN MX:5OkBp MlT5TWM2OD1yLkGyO{DPxE1? MlPMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzMEizN|goRjJyMUC4N|M5RC:jPh?=
GSS Mo\MRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MWO3NkBpenN? NEXQWlRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFfTV{Bk\WyuczDh[pRmeiB5MjDodpMh[nliV2PUPEBie3OjeTygTWM2OCB;IECuNFM6KM7:TT6= NXrGd3FYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2NlU3OTdpPkK1OlI2PjF5PD;hQi=>
LU99A NFX3XGhCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M2W0XVczKGi{cx?= MlT3RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCOVUm5RUBk\WyuczDh[pRmeiB5MjDodpMh[nliV2PUPEBie3OjeTygTWM2OCB;IECuNFYzKM7:TT6= Mnz2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4MkW2NVcoRjJ3NkK1OlE4RC:jPh?=
HL60 Moj4RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NFG5VHo4OiCqcoO= M13P[2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFy2NEBk\WyuczDh[pRmeiB5MjDodpMh[nliV2PUPEBie3OjeTygTWM2OCB;IECuNFc1KM7:TT6= MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ{NU[xO{c,OjV4MkW2NVc9N2F-
LC2/ad M{jyVmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M4H5eVczKGi{cx?= MmjvRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCOQ{KvZYQh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IGfTWFgh[XO|YYmsJGlEPTBiPTCwMlA4PyEQvF2u NUnMR4VnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2NlU3OTdpPkK1OlI2PjF5PD;hQi=>
MKN45 MmTuRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NH\IPII4OiCqcoO= MnOzRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPS160OUBk\WyuczDh[pRmeiB5MjDodpMh[nliV2PUPEBie3OjeTygTWM2OCB;IECuNFk{KM7:TT6= NYTsfHBGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2NlU3OTdpPkK1OlI2PjF5PD;hQi=>
HCT116 Ml;JRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NIrXZW04OiCqcoO= MULBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEGxOkBk\WyuczDh[pRmeiB5MjDodpMh[nliV2PUPEBie3OjeTygTWM2OCB;IECuNFk2KM7:TT6= NXPwS4oxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2NlU3OTdpPkK1OlI2PjF5PD;hQi=>
Lu116 NXG1WXVtSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MmKzO|IhcHK| NUfCdpZjSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDMeVEyPiClZXzsd{Bi\nSncjC3NkBpenNiYomgW3NVQCCjc4PhfUwhUUN3MDC9JFAvODl5IN88UU4> NHPqWZc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[yOVYyPyd-MkW2NlU3OTd:L3G+
NCI-H358 MULBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M17iR|czKGi{cx?= M4nWV2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWg{PThiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JHdUXDhiYYPzZZktKEmFNUCgQUAxNjFizszNMi=> M1q4NVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkK1OlE4Lz5{NU[yOVYyPzxxYU6=
MIAPaCa2 MUnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NYPo[XhGPzJiaILz MWnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2LQWDhR4EzKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDXV3Q5KGG|c3H5MEBKSzVyIE2gNE4yOyEQvF2u MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ{NU[xO{c,OjV4MkW2NVc9N2F-
PC14 NGS2fIdCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NHHkfJU4OiCqcoO= MUPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFCFMUSgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KFeVVEigZZN{[XluIFnDOVAhRSByLkG3JO69VS5? NFXZUJQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[yOVYyPyd-MkW2NlU3OTd:L3G+
HT-29 NULqO5N3SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M1LOeFczKGi{cx?= M1K0WmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSGStNlkh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IGfTWFgh[XO|YYmsJGlEPTBiPTCwMlM{KM7:TT6= Ml72QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4MkW2NVcoRjJ3NkK1OlE4RC:jPh?=
HCT15 MnX1RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MUe3NkBpenN? Mn;WRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ2SxOUBk\WyuczDh[pRmeiB5MjDodpMh[nliV2PUPEBie3OjeTygTWM2OCB;IECuO|Qh|ryPLh?= MlrXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4MkW2NVcoRjJ3NkK1OlE4RC:jPh?=
Sf9 NV:zUmg6TnWwY4Tpc44h[XO|YYm= NUn3fFR7S2:vcHX0bZRqfmViaX7obYJqfGmxbjDv[kBz\WOxbXLpcoFvfCCvb4Xz[UBifXKxcnGgb4lv[XOnIFGg[ZhxemW|c3XkJIlvKGmwc3XjeEBU\jliY3XscJMhcW5icILld4Vv[2Vib3[gRXRRNCCNaTC9JFAvODByMzFOwG0v NGny[W89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkGwNVU3PCd-Mk[xNFE2PjR:L3G+
Sf9 NFLlb|FHfW6ldHnvckBie3OjeR?= MlPuTY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDtc5V{\SCjdYLvdoEhc2mwYYPlJGEh\XiycnXzd4VlKGmwIHnud4VkfCCVZkmgZ4VtdHNidYPpcoch[mmxdHnuMWdNWlKDU1zHJIF{KHO3YoP0doF1\SCrbjDwdoV{\W6lZTDv[kBc\2GvbXGtN|NRZUGWUDygTWM2OCB;IECuNFAyKM7:TT6= NEC4XmY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkGwNVU3PCd-Mk[xNFE2PjR:L3G+
HCT116 M2D4PWZ2dmO2aX;uJIF{e2G7 NYDicnlnUW6qaXLpeIlwdiCxZjDheZJwemFia3nuZZNmKEFiYYX0c5Bpd3OyaH;yfYxifGmxbjDheEBVOjh6IHnuJIh2dWGwIFjDWFEyPiClZXzsd{BjgSCrbX31co9ndHWxcnXzZ4Vv[2ViYX7hcJl{cXNuIFnDOVAhRSByLkCwO{DPxE1w MnLuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzMEG1OlQoRjJ4MUCxOVY1RC:jPh?=
HCT116 M3PSZWN6fG:2b4jpZ4l1gSCjc4PhfS=> MU\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuIIDyc4xq\mW{YYTpc44h[nliQoLkWUBqdmOxcoDvdoF1cW:wIHHzd4F6NCCJSUWwJF0hOC5yMzFOwG0v MnLIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzMEG1OlQoRjJ4MUCxOVY1RC:jPh?=
HCT116 MULGeY5kfGmxbjDhd5NigQ>? MmjnTY5pcWKrdHnvckBw\iCjdYLvdoEhc2mwYYPlJGIhcW5iaIXtZY4hUEOWMUG2JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiaHnzeI9v\SCKMzDwbI9{eGixconsZZRqd25iYomgbY1ufW6xZnz1c5Jme2OnbnPlJIFv[Wy7c3nzMEBKSzVyIE2gNU42KM7:TT6= MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjFyMUW2OEc,OjZzMEG1OlQ9N2F-
BL21 (DE3) Rosetta M3PZSWZ2dmO2aX;uJIF{e2G7 MljNN|AhdWmwcx?= M3TlV2lvcGmkaYTpc44hd2ZiSHnzMZRi\2enZDDoeY1idiCDdYLvdoEhSSCtaX7hd4UhMDF{MjD0c{A1OCC{ZYPp[JVmeyliZYjwdoV{e2WmIHnuJGV{[2incnnjbIliKGOxbHmgRmwzOSBqRFWzLUBTd3OndIThJINmdGy|IIXzbY5oKGKrb4Tpcplt[XSnZDDTWGszKHO3YoP0doF1\SCrbnP1ZoF1\WRiZn;yJFMxKG2rboOgZpkhUFSURjDhd5NigSxiSVO1NEA:KDBwMECwNFQh|ryPLh?= M37FPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5M{mxNVM{Lz5{N{O5NVE{OzxxYU6=
HeLa Kyoto NUjHWohRTnWwY4Tpc44h[XO|YYm= NVyzWpVNOjBiaILz MX;Jcohq[mm2aX;uJI9nKEG3cn;yZUBDKGurbnHz[UBqdiCqdX3hckBJ\UyjIFv5c5RwKGOnbHzzJIF{e2W|c3XkJIF{KGWoZnXjeEBwdiCmaYP0doljfXSrb36gc4YheGi|cHjvMYhqe3SxbnWgTFMhe2W{MUCgcIV3\WxiaX7jeYJifGWmIH\vdkAzOCCqcoOsJGlEPTBiPTCwMlAxOTVizszNMi=> NH:0NFQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{O5NVE{Oyd-MkezPVEyOzN:L3G+
HeLa Kyoto NV;hZ3A5TnWwY4Tpc44h[XO|YYm= MYiyNEBpenN? NXyzNYdHUW6qaXLpeIlwdiCxZjDBeZJwemFiQTDrbY5ie2ViYYX0c5Bpd3OyaH;yfYxifGmxbjDheEBVcHJ{OEigbY4hcHWvYX6gTIVN[SCNeX;0c{Bk\WyuczDpcoN2[mG2ZXSg[o9zKDJyIHjyd{whUUN3MDC9JFAvODB4NzFOwG0v MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzN7MUGzN{c,Ojd|OUGxN|M9N2F-
multiple myeloma NGfhSXNHfW6ldHnvckBie3OjeR?= MluxV5VxeHKnc4Ppc44hd2ZiY3XscEBucXSxc3nzJIlvKGi3bXHuJI12dHSrcHzlJI16\WyxbXGgZ4VtdHNuIFnDOVAhRSByLkCwN{DPxE1w NV7uNpp1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5NVgxQTZpPkK4PVE5ODl4PD;hQi=>
Calu6 MoHvRY51cXS3bX;yJIF{e2G7 Mn3tNlAhdWdxa3e= NWLQW|MzOjFiZHH5dy=> MlLNRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQ3HseVYh[2WubIOgfIVvd2e{YX\0[YQhcW5ibX;1d4Uh[XO|ZYPz[YQh[XNidIXtc5Ih\3Kxd4ToJIlvcGmkaYTpc44h[XRiMkCgcYcwc2duIIDvJIJq\CCjZH3pcol{fGW{ZXSg[o9zKDJzIHThfZM> M4HiNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MUCxOVY1Lz5{NkGwNVU3PDxxYU6=
HeLa Kyoto MXTGeY5kfGmxbjDhd5NigQ>? M4DvSlAvOjVidV2= M4HwUFIxKGi{cx?= NF;KeWNKdmirYnn0bY9vKG:oIFH1do9z[SCDIHvpcoF{\SCub3PhcIl7[XSrb36gZZQhe3CrbnTs[UBucWO{b4T1ZpVt\XNiaX6gbJVu[W5iSHXMZUBMgW:2bzDj[YxteyCjdDCwMlI2KHWPIHnuZ5Vj[XSnZDDmc5IhOjBiaILz NH7aRVU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{O5NVE{Oyd-MkezPVEyOzN:L3G+
MDA-MB-231 NEHFV3NHfW6ldHnvckBie3OjeR?= NYr6SVJbOSC3TR?= NEjGTHc1QCCqcoO= MkiwTY5lfWO2aX;uJI9nKGOqcn;tc5NwdWViYXzp[45u\W62IHTl[oVkfHNiaX6gbJVu[W5iTVTBMW1DNTJ|MTDj[YxteyCjdDCxJJVOKGGodHXyJFQ5KGi{czDifUBFSVCLIIP0ZYlvcW6pIHLhd4VlKGmvbYXuc4ZtfW:{ZYPj[Y5k\SCjc4PhfS=> MmPpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl|NUixOFcoRjJ7M{W4NVQ4RC:jPh?=
MDA-MB-231 MmTNSpVv[3Srb36gZZN{[Xl? M2j2TlEhfU1? NH3VPY41QCCqcoO= Ml\QTY5lfWO2aX;uJI9nKGGkZYLyZY51KHOyaX7kcIUh\m:{bXH0bY9vKHerdHigeJJqeG:uYYKgZY5lKHSndILhdI9t[XJib3PjeZJz\W6lZTDpckBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHH0JFEhfU1iYX\0[ZIhPDhiaILzJIJ6KESDUFmgd5RicW6rbnegZoF{\WRiaX3teY5w\my3b4Lld4NmdmOnIHHzd4F6 MlLiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl|NUixOFcoRjJ7M{W4NVQ4RC:jPh?=
MDA-MB-231 MXzGeY5kfGmxbjDhd5NigQ>? M{K0c|AvPSC3TR?= NXrJTW91PDhiaILz M2\jc2lvcGmkaYTpc44hd2ZiYXzwbIEufHWkdXzpckBqdiCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIF{e2W|c3XkJIF{KGGkb3zpd4hu\W62IH;mJJJm\3WuYYKgcI9k[XSrb36gc4YheHKxdHXpckBifCByLkWgeW0h[W[2ZYKgOFghcHK|IHL5JGRCWElic4ThbY5qdmdiYnHz[YQhcW2vdX7v[ox2d3Knc3PlcoNmKGG|c3H5 MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTN3OEG0O{c,Ojl|NUixOFc9N2F-
MDA-MB-231 M1HZT2Z2dmO2aX;uJIF{e2G7 NVj1NmpZOC53IIXN NIDUXY41QCCqcoO= NVTQUJlLUW6qaXLpeIlwdiCxZjDBWXJMSSCrbjDoeY1idiCPRFGtUWIuOjNzIHPlcIx{KGG|c3Xzd4VlKGG|IHHic4xqe2ivZX70JI9nKHKnZ4XsZZIhdG:lYYTpc44hd2ZicILveIVqdiCjdDCwMlUhfU1iYX\0[ZIhPDhiaILzJIJ6KESDUFmgd5RicW6rbnegZoF{\WRiaX3teY5w\my3b4Lld4NmdmOnIHHzd4F6 M1TJZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7M{W4NVQ4Lz5{OUO1PFE1PzxxYU6=
TC32 NI\xdodyUFSVIHHzd4F6 MYXxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhXEN|MjDj[Yxtew>? MlvRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
Saos-2 NVj3UY9CeUiWUzDhd5NigQ>? NWKzN4VxeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IGPhc5MuOiClZXzsdy=> MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
SK-N-SH M2m2dJFJXFNiYYPzZZk> NVrSeoRreUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IGPLMW4uW0hiY3XscJM> MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
MG 63 (6-TG R) MYHxTHRUKGG|c3H5 MYHxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhVUdiNkOgLFYuXEdiUjmgZ4VtdHN? NWPWZ2NjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
NB1643 MV;xTHRUKGG|c3H5 NX24TXdSeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IF7CNVY1OyClZXzsdy=> NIr5TJk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
NB-EBc1 NFPJdJpyUFSVIHHzd4F6 NF3ue2FyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBPSi2HQnOxJINmdGy| MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
MG 63 (6-TG R) NWewXI54eUiWUzDhd5NigQ>? MUfxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDNS{A3OyBqNj3US{BTMSClZXzsdy=> MlvhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
U-2 OS M{WyXpFJXFNiYYPzZZk> MV3xTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDVMVIhV1NiY3XscJM> MmnYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
SJ-GBM2 MkTSdWhVWyCjc4PhfS=> MUjxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhW0pvR1LNNkBk\Wyucx?= NE\IXoU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
SK-N-MC NYXrVlRueUiWUzDhd5NigQ>? M3HN[5FJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCVSz3OMW1EKGOnbHzz MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
NB-EBc1 NUDVXI9KeUiWUzDhd5NigQ>? Mn:xdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKE6ELVXCZ|Eh[2WubIO= NIDzfWg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
LAN-5 M4ezZZFJXFNiYYPzZZk> NWj1NnVleUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IFzBUk02KGOnbHzz MmHaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
Rh18 MVvxTHRUKGG|c3H5 NIX2WHFyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiUnixPEBk\Wyucx?= M4jGN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SK-N-MC MXfxTHRUKGG|c3H5 NUTUTYNEeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhW0tvTj3NR{Bk\Wyucx?= NGnEdYc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
TC32 NEO5b|VyUFSVIHHzd4F6 NYHUTpl4eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhXEN|MjDj[Yxtew>? NIrJfow9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
Saos-2 NH3hO2lyUFSVIHHzd4F6 M3;jWJFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJHNid3NvMjDj[Yxtew>? Mnf6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-AURKA(T288) / p-EIF4E(S209) / c-Myc; 

PubMed: 28073841     


Inhibition of AURKA with alisertib downregulated p-EIF4E (S209) and c-MYC protein levels as assayed by Western blotting.

phospho-Aurora A / Aurora B; 

PubMed: 22863010     


MLN8237differentially inhibited phosphorylation of Aurora kinases. CMK cells were incubated with 0.1 µM paclitaxel for 18 hr, then DMSO or MLN8237 was added and incubated for 2 hr. The degree of phosphorylation of the Aurora kinases in each sample was determined by Western blot.

H3S10P / H3K27me2 / H3K27me3 / H3K9me2 / H3AcK / H4K16Ac; 

PubMed: 29477140     


THP-1 cells were treated with alisertib or DMSO for 48 h. The levels of histone modifications were detected by western blot analysis with the indicated antibodies. H3 was used as a loading control.

28073841 22863010 29477140
Growth inhibition assay
Cell viability; 

PubMed: 25632225     


PANC-1 and BxPC-3 cells were treated with ALS at concentrations ranging from 0.1 μM to 50 μM for 24 hours. The viability of PANC-1 and BxPC-3 cells determined by MTT assay. ALS, alisertib.

25632225
Immunofluorescence
acetylated α-tubulin / γ-tubulin; 

PubMed: 29401581     


Representative immunofluorescence (IF) image and graph in human PKD1-mutant WT9-7, WT9-12 cells or hTERT-RPE1 (RPE1) cells after 2 hours treatment with vehicle, ganetespib , or alisertib to inhibit AURKA, or combination of alisertib and ganetespib. acetylated α-tubulin (red); γ-tubulin (green); DAPI (blue). Scale bars, 5 μm.

E-cadherin / β-catenin / vimentin / p-SMAD5; 

PubMed: 23334326     


Immunofluorescence analysis of CD24 (-/low) cells treated with1 μM MLN8237 for 48 and 72 h showing reversion of EMT. E-cadherin and p-SMAD5 were labeled in red, β-catenin and vimentin were labeled in green, and DNA was labeled in blue with Hoechst dye.

Centrin-2 / tubulin; 

PubMed: 30899434     


Following inhibition of Aurora A kinase activity with 100 nM alisertib, cells with two or excess centrosomes similarly exhibit disorganized mitotic spindles. Cells with extra centrosomes are efficiently clustered into bipolar spindles prior to anaphase onset while those with supernumerary centrosomes undergo multipolar mitoses. Centrin-2, a marker of centrioles is shown in green, tubulin in red, and chromatin in blue. AurA inhibitor: alisertib.

phospho-Aurora A(T288); 

PubMed: 20382844     


MM1.S cells were treated with DMSO or MLN8237 (0.5μM) for 24 hours and then stained with anti-phospho (Thr288)-Aurora-A kinase antibody (red), αtubulin (green), and DNA (blue). Overlapping localization is shown in the merged images. Arrow indicates Aurora-A autophosphorylation on Thr288 in the centrosome (original magnification ×40). Magnified single mitotic cell image is shown in the right panel. 

29401581 23334326 30899434 20382844
体内研究 MLN8237口服处理,显著降低肿瘤负担,按15 mg/kg 和30 mg/kg剂量处理肿瘤生长抑制率(TGI) 分别为42%和80%,且与对照组相比,延迟小鼠寿命。[2] MLN8237 (30 mg/kg) 与Cisplatin (2 mg/kg) 联用作用于FLO-1移植瘤,与单独用药相比,抗癌活性增强,伴随着Ki-67表达受抑制,细胞核p73蛋白和cleaved caspase 3表达增强。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[1]
- 合并

Aurora A放射性闪光板酶实验:

进行Aurora A放射性闪光板酶实验,测定体外MLN8237抑制程度。在Sf9细胞中表达重组Aurora A,然后使用GST亲和层析进行纯化。Aurora A 肽底物与生物素联合形成生物素-GLRRASLG。在50 mM Hepes (pH 7.5), 10 mM MgCl2, 5 mM DTT, 0.05% Tween-20, 2 μM 肽底物, 3.3 μCi/mL [γ-33 P]ATP 2 μM, 和浓度不断增高的MLN8237 的混合物中进行Aurora A激酶 (5 nM)实验。
细胞实验:[2]
- 合并
  • Cell lines: MM1.S, MM.1R, LR5, RPMI 8226, DOX40, OPM1, OPM2, INA6, 和U266
  • Concentrations: 溶于DMSO,终浓度为~10 μM
  • Incubation Time: 24, 48, 和72小时
  • Method: 使用不同浓度MLN8237处理细胞24, 48,和72小时。通过MTT实验测定细胞活力,通过测定 3[3H]-胸甘渗透而测定细胞增殖。为了分析细胞周期,使用70%乙醇在-20oC下使细胞通透,然后与50 μg/mL PI 和20 单位/mL RNase-A温育。 通过流式细胞仪使用 BDFACS-Canto II和FlowJo软件分析DNA含量。 为了测定凋亡和衰老,使用异硫氰酸荧光素-annexin V和PI对细胞进行染色。通过流式细胞仪使用 BDFACS-Canto II和FlowJo软件测定凋亡细胞。
    (Only for Reference)
动物实验:[2]
- 合并
  • Animal Models: 皮下接种 MM1.S 细胞的SCID鼠
  • Dosages: ~30 mg/kg/day
  • Administration: 口服处理
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 27 mg/mL (52.03 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5%DMSO+30% PEG300+5%Tween-80+ddH2O
6mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 518.92
化学式

C27H20ClFN4O4

CAS号 1028486-01-2
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04479306 Recruiting Drug: Alisertib|Drug: Osimertinib|Drug: Sapanisertib EGFR T790M Mutation Positive Non-Small Cell Lung Carcinoma|Recurrent Lung Non-Small Cell Carcinoma|Stage IIIB Lung Cancer AJCC v8|Stage IV Lung Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8 M.D. Anderson Cancer Center|National Cancer Institute (NCI) June 18 2020 Phase 1
NCT02812056 Withdrawn Drug: Alisertib|Drug: TAK-228 Malignant Neoplasms of Digestive Organs|Malignant Neoplasms of Female Genital Organs|Malignant Neoplasms of Lip Oral Cavity and Pharynx|Malignant Neoplasms of Male Genital Organs M.D. Anderson Cancer Center|Millennium Pharmaceuticals Inc. September 2016 Phase 1
NCT02719691 Active not recruiting Drug: Alisertib|Drug: MLN0128 Metastatic Breast Cancer|Solid Tumors University of Colorado Denver May 13 2016 Phase 1
NCT02367352 Terminated Drug: Alisertib|Drug: Paclitaxel Advanced Solid Tumors|Ovarian Cancer|Small Cell Lung Cancer Millennium Pharmaceuticals Inc.|Takeda March 19 2015 Phase 1

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    What is the suggested formulation of this compound for mouse injection(i.p.)?

  • 回答:

    It can be dissolved in 6% DMSO/50% PEG 300/5% Tween 80/ddH2O at 10 mg/ml as a clear solution.

Aurora Kinase Signaling Pathway Map

Aurora Kinase Inhibitors with Unique Features

相关Aurora Kinase产品

Tags: 购买Alisertib (MLN8237) | Alisertib (MLN8237)供应商 | 采购Alisertib (MLN8237) | Alisertib (MLN8237)价格 | Alisertib (MLN8237)生产 | 订购Alisertib (MLN8237) | Alisertib (MLN8237)代理商
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID