Alisertib (MLN8237)

For research use only. Not for use in humans.

目录号:S1133 中文名称:阿利色替

Alisertib (MLN8237) Chemical Structure

CAS No. 1028486-01-2

Alisertib (MLN8237)是一种选择性Aurora A抑制剂,无细胞试验中IC50为1.2 nM,作用于Aurora A比作用于Aurora B选择性强200倍以上。Alisertib 可诱导细胞周期阻滞、细胞凋亡与自噬。Phase 3。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1375.12 现货
RMB 983.87 现货
RMB 1725.78 现货
RMB 5505.84 现货
RMB 14496.3 现货
有超大折扣

今日订购,明日送达,全国免运费!

全国免费电话:400-668-6834   |   Email:info@selleck.cn

客户使用Selleck生产的Alisertib (MLN8237)发表文献277篇:

产品安全说明书

Aurora Kinase抑制剂选择性比较

生物活性

产品描述 Alisertib (MLN8237)是一种选择性Aurora A抑制剂,无细胞试验中IC50为1.2 nM,作用于Aurora A比作用于Aurora B选择性强200倍以上。Alisertib 可诱导细胞周期阻滞、细胞凋亡与自噬。Phase 3。
特性 MLN8237 是第一个口服有效的小分子Aurora A激酶选择性抑制剂。
靶点
Aurora A [1]
(Cell-free assay)
1.2 nM
体外研究

MLN8237作用于Aurora A选择性比作用于结构相关的Aurora B 高200多倍,IC50为396.5 nM, 而对205种其他激酶则没有显著活性。[1] 0.5 μM MLN8237处理MM1.S和 OPM1 细胞,抑制 Aurora A磷酸化,而不影响 Aurora B调节的组蛋白H3磷酸化。MLN8237作用于多发性骨髓瘤(MM) 细胞系,显著抑制细胞增殖,IC50为0.003-1.71 μM。在BM 基质细胞,IL-6和 IGF-1 存在时,MLN8237作用于原代MM 细胞和MM细胞系,抗增殖活性比只有MLN8237单独作用时高很多。0.5 μM MLN8237 作用于原代MM细胞和细胞系,使G2/M 期细胞提高2到6倍,且显著诱导凋亡和衰老,涉及p53, p21 和p27的上调,及 PARP,caspase 3,和 caspase 9的裂解。此外, MLN8237和 Dexamethasone联用具有协同作用,具有强抗MM 功效, 而和Doxorubicin 及Bortezomib联用则具有另外的功能。[2] 0.5 μM MLN8237处理 FLO-1, OE19, 和OE33 食管腺癌细胞系,抑制集落形成,且显著提高多倍体细胞百分数,随后提高G1期细胞百分数,而与 Cisplatin (2.5 μM)联用则效果进一步提高,与单独用药相比,诱导产生更多, TAp73β, PUMA, NOXA, cleaved caspase-3, 和cleaved PARP。[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HCT116 MlHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\WNE42KM7:TR?= MV[3NkBp NFW0cW9FVVOR M3zpb2lEPTB;MD6wOEDPxE1? MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF|Nk[4OEc,OjZzM{[2PFQ9N2F-
LS174T NVHlPXNIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjLfll6OC53IN88US=> Ml7nO|IhcA>? MlvFSG1UVw>? NVroUmlNUUN3ME2wMlA2KM7:TR?= NH[2Vpo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkGzOlY5PCd-Mk[xN|Y3QDR:L3G+
T84 NIHpUmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\1bVJSOC53IN88US=> NGPGNG44OiCq NGLuVVVFVVOR NGflVnJKSzVyPUCuNFkh|ryP MlnuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzM{[2PFQoRjJ4MUO2Olg1RC:jPh?=
LS180 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NESxS4YxNjVizszN MXy3NkBp NE\ZcG1FVVOR NGT4[|dKSzVyPUGg{txO M{PYXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MUO2Olg1Lz5{NkGzOlY5PDxxYU6=
SW948 NXvaRok5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE[2c4kxNjVizszN NUnMXmNTPzJiaB?= NF;YbXFFVVOR NGjWVGdKSzVyPUGg{txO NYq3Nph{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xN|Y3QDRpPkK2NVM3Pjh2PD;hQi=>
HCT15 NX\XSFRDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rqTlAvPSEQvF2= NGH3[lc4OiCq M1HMZmROW09? MkDlTWM2ODxyLkSg{txO MkmzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzM{[2PFQoRjJ4MUO2Olg1RC:jPh?=
DLD-1 NVy3Xo81T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnONE42KM7:TR?= MX[3NkBp MX7EUXNQ MYLJR|UxRDBwODFOwG0> M1PudVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MUO2Olg1Lz5{NkGzOlY5PDxxYU6=
MIP-101 Mne0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjmSHAxNjVizszN NVfte2JNPzJiaB?= MWfEUXNQ NV7FUJY6UUN3ME2xJO69VQ>? NF;r[3A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkGzOlY5PCd-Mk[xN|Y3QDR:L3G+
SNU1544 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrjdWoxNjVizszN NX7wUGFnPzJiaB?= NEm3T3ZFVVOR MnmzTWM2OD1zIN88US=> NY[3R3pZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xN|Y3QDRpPkK2NVM3Pjh2PD;hQi=>
OCI-Ly10 MYrDfZRwfG:6aXOgRZN{[Xl? M2DzbFczKGh? MnG1SG1UVw>? NYrSV2gxUUN3ME2wMlA2QCEQvF2= Mmf2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6N{izN|EoRjJ3OEe4N|MyRC:jPh?=
SU-DHL2 NX;FeZp1S3m2b4TvfIlkKEG|c3H5 NFTHTnE4OiCq NHXwXGpFVVOR MmWyTWM2OD1yLkCxJO69VQ>? MoLpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6N{izN|EoRjJ3OEe4N|MyRC:jPh?=
OCI-LY7 MVzDfZRwfG:6aXOgRZN{[Xl? MV:3NkBp NGjoOIZFVVOR MmrHTWM2OD1yLkC4NUDPxE1? MnXtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6N{izN|EoRjJ3OEe4N|MyRC:jPh?=
SU-DHL6 Ml\DR5l1d3SxeHnjJGF{e2G7 NH73VYs4OiCq Mn;wSG1UVw>? M4S5S2lEPTB;MD60PFIh|ryP Mnv5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6N{izN|EoRjJ3OEe4N|MyRC:jPh?=
Jeko-1 NXHuZXZzS3m2b4TvfIlkKEG|c3H5 MlrZO|IhcA>? MUDEUXNQ MU\JR|UxRTBwMEK5JO69VQ>? Ml3kQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6N{izN|EoRjJ3OEe4N|MyRC:jPh?=
JVM-2 MmS3R5l1d3SxeHnjJGF{e2G7 MXq3NkBp MV;EUXNQ MUTJR|UxRTBwMEGg{txO NWHLXG1URGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4O|g{OzFpPkK1PFc5OzNzPD;hQi=>
Rec-1 NE\4codEgXSxdH;4bYMhSXO|YYm= NYnhdYZNPzJiaB?= NXjxeIN[TE2VTx?= NWPnPZVoUUN3ME2wMlA5PyEQvF2= MonqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6N{izN|EoRjJ3OEe4N|MyRC:jPh?=
Z-138 NV;yOWtRS3m2b4TvfIlkKEG|c3H5 MmTKO|IhcA>? NF7s[W9FVVOR MkjrTWM2OD1yLkCxN{DPxE1? MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh5OEOzNUc,OjV6N{izN|E9N2F-
H9 M{n4RWN6fG:2b4jpZ{BCe3OjeR?= MVy3NkBp MlLvSG1UVw>? NHvXbZZKSzVyPUCuOkDPxE1? MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh5OEOzNUc,OjV6N{izN|E9N2F-
HH MX3DfZRwfG:6aXOgRZN{[Xl? NV\UOJZmPzJiaB?= MoG2SG1UVw>? M4\RfGlEPTB;MD63JO69VQ>? NH\K[JQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi3PFM{OSd-MkW4O|g{OzF:L3G+
DND41 M4jZN2N6fG:2b4jpZ{BCe3OjeR?= MWK3NkBp MUXEUXNQ NX;rO5hOUUN3ME2wMlEh|ryP MnfXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6N{izN|EoRjJ3OEe4N|MyRC:jPh?=
CCL119 MnnSR5l1d3SxeHnjJGF{e2G7 NW\Pd|Y4PzJiaB?= NYPa[HlTTE2VTx?= MVTJR|UxRTBwME[yJO69VQ>? NF\lOHA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi3PFM{OSd-MkW4O|g{OzF:L3G+
J.Cam 1.6 MWHDfZRwfG:6aXOgRZN{[Xl? MmjPO|IhcA>? NYr4NolITE2VTx?= M1fLTGlEPTB;MD6xNFUh|ryP NUnVZ2N5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4O|g{OzFpPkK1PFc5OzNzPD;hQi=>
Sup-T1 NIL2N5hEgXSxdH;4bYMhSXO|YYm= MlnaO|IhcA>? NWKwVFB{TE2VTx?= NXrFdnhtUUN3ME2yMlE1OiEQvF2= MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh5OEOzNUc,OjV6N{izN|E9N2F-
Tib 152 MoLpR5l1d3SxeHnjJGF{e2G7 MVy3NkBp NYjPb2Y5TE2VTx?= MljSTWM2OD1yLkig{txO MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh5OEOzNUc,OjV6N{izN|E9N2F-
MCF7 NHTU[lZHfW6ldHnvckBCe3OjeR?= M3rmclUh|ryP MUCyOEBp MXrEUXNQ M1TTbGlv\HWlZYOgS|IwVSCjcoLld5Q> NF\rZW89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUizOFQxOSd-MkW4N|Q1ODF:L3G+
MDA-MB-231 NHXJXnBHfW6ldHnvckBCe3OjeR?= M2HyUFUh|ryP M1zsS|I1KGh? NYrPNlZmTE2VTx?= MVrJcoR2[2W|IFezM20h[XK{ZYP0 NV\hOINWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4N|Q1ODFpPkK1PFM1PDBzPD;hQi=>
MCF7 MonXSpVv[3Srb36gRZN{[Xl? NF\kdpA2KM7:TR?= M{H1Z|I1KGh? M1zzbWROW09? NEPaXI9F\WO{ZXHz[ZMhfGinIHX4dJJme3Orb36gcIV3\Wxib3[gR2RMOS:FRFOy M1[2WVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEO0OFAyLz5{NUizOFQxOTxxYU6=
MCF7 MYHGeY5kfGmxbjDBd5NigQ>? MXu1JO69VQ>? MkO2NlQhcA>? M4LjUmROW09? NHLBXoxF\WO{ZXHz[ZMhfGinIHX4dJJme3Orb36gcIV3\Wxib3[gR2RMOg>? NUXuO|BvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4N|Q1ODFpPkK1PFM1PDBzPD;hQi=>
MCF7 MXnGeY5kfGmxbjDBd5NigQ>? NXLuc5hnPSEQvF2= Mm\ZNlQhcA>? MUnEUXNQ NETEVGJF\WO{ZXHz[ZMhfGinIHX4dJJme3Orb36gcIV3\Wxib3[gZ5lkdGmwIFKx MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh|NESwNUc,OjV6M{S0NFE9N2F-
MCF7 M2nKTWZ2dmO2aX;uJGF{e2G7 MYi1JO69VQ>? MWmyOEBp NV7Z[|NrTE2VTx?= MoPXTY5kemWjc3XzJJRp\SCneIDy[ZN{cW:wIHzleoVtKG:oIICyNUBY[WZzL1PpdFE> M{C3Z|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEO0OFAyLz5{NUizOFQxOTxxYU6=
MCF7 MXjGeY5kfGmxbjDBd5NigQ>? M{jJfVUh|ryP NHrSS4szPCCq NXXPTJdZTE2VTx?= NX3vTZBLUW6lcnXhd4V{KHSqZTDlfJBz\XO|aX;uJIxmfmWuIH;mJJAzPyCNaYCx MmSwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6M{S0NFEoRjJ3OEO0OFAyRC:jPh?=
MDA-MB-231 NGTYUY1HfW6ldHnvckBCe3OjeR?= M1\Le|Uh|ryP NFq2bWMzPCCq NUfMSWhyTE2VTx?= M1O4TWRm[3KnYYPld{B1cGViZYjwdoV{e2mxbjDs[ZZmdCCxZjDDSGsyN0OGQ{K= MlrkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6M{S0NFEoRjJ3OEO0OFAyRC:jPh?=
MDA-MB-231 NELXbVdHfW6ldHnvckBCe3OjeR?= MmHDNUDPxE1? M3PkW|I1KGh? MXPEUXNQ NVvhcJJrUW6lcnXhd4V{KHSqZTDlfJBz\XO|aX;uJIxmfmWuIH;mJGNFUzJ? NYS1WnpURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4N|Q1ODFpPkK1PFM1PDBzPD;hQi=>
MDA-MB-231 NFLyNllHfW6ldHnvckBCe3OjeR?= NXfpVXZYPSEQvF2= M{\xd|I1KGh? M3vDeWROW09? NVjCOGVyTGWlcnXhd4V{KHSqZTDlfJBz\XO|aX;uJIxmfmWuIH;mJIN6[2yrbjDCNS=> NXzJdVdQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4N|Q1ODFpPkK1PFM1PDBzPD;hQi=>
MDA-MB-231 MWnGeY5kfGmxbjDBd5NigQ>? MUC1JO69VQ>? MWGyOEBp NFXETHVFVVOR MmrKTY5kemWjc3XzJJRp\SCneIDy[ZN{cW:wIHzleoVtKG:oIICyNUBY[WZzL1PpdFE> M2HvZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEO0OFAyLz5{NUizOFQxOTxxYU6=
MDA-MB-231 MXfGeY5kfGmxbjDBd5NigQ>? MV:1JO69VQ>? M2DEeFI1KGh? MWfEUXNQ MXvJcoNz\WG|ZYOgeIhmKGW6cILld5Nqd25ibHX2[Ywhd2ZicEK3JGtqeDF? NFPvTHY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUizOFQxOSd-MkW4N|Q1ODF:L3G+
MDA-MB-231 MV\GeY5kfGmxbjDBd5NigQ>? NGjDZ|E2KM7:TR?= M2fjcFI1KGh? MXHEUXNQ Mnu3TY5kemWjc3XzJJRp\SCneIDy[ZN{cW:wIHzleoVtKG:oIIC1Ny=> MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh|NESwNUc,OjV6M{S0NFE9N2F-
MCF7 NEPzO5RCeG:ydH;zbZMhSXO|YYm= NEXkTJQ2KM7:TR?= MX[yOEBp MknkSG1UVw>? MmHvTY5lfWOnczDhdI9xfG:2aXOg[IVifGh? M3jNfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEO0OFAyLz5{NUizOFQxOTxxYU6=
MDA-MB-231 NUOwfnNzSXCxcITvd4l{KEG|c3H5 M3;IV|Uh|ryP NX3GSlVuOjRiaB?= Mn7NSG1UVw>? NFTKO3JKdmS3Y3XzJIFxd3C2b4TpZ{Bl\WG2aB?= MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh|NESwNUc,OjV6M{S0NFE9N2F-
MCF7 NYrvXYN3TnWwY4Tpc44hSXO|YYm= NXnhc4tlOSEQvF2= NF;PNoI4OiCq M3nvWmROW09? MX3JcoR2[2W|IHH1eI9xcGGpaXOg[IVifGh? Mn;3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6M{S0NFEoRjJ3OEO0OFAyRC:jPh?=
MDA-MB-231 NULVbpdxTnWwY4Tpc44hSXO|YYm= NIm3SVcyKM7:TR?= MUG3NkBp MkHqSG1UVw>? M3;5U2lv\HWlZYOgZZV1d3CqYXfpZ{Bl\WG2aB?= M4i1fVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEO0OFAyLz5{NUizOFQxOTxxYU6=
U-2 OS MlnSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHm0PWI2OCEQvF2= NXnPWIZPOjRiaB?= NX;pO495TE2VTx?= M1q3UWlEPTB;MU[uOkDPxE1? NXHnXoRMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3PVI5OTFpPkK1O|kzQDFzPD;hQi=>
MG-63 MkjSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLWOVAh|ryP NX;uRpBoOjRiaB?= M1y3XmROW09? NYDlRW12UUN3ME25MlUh|ryP MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd7MkixNUc,OjV5OUK4NVE9N2F-
U-2 OS NXvYWZg6SXCxcITvd4l{KEG|c3H5 NGDZT5I2KM7:TR?= NIG4bWEzPCCq M{W5VmROW09? MUHJcoR2[2W|IHHwc5B1d3SrYzDj[YxtKGSnYYTo M1zOeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{myPFEyLz5{NUe5NlgyOTxxYU6=
MG-63 MlLkRZBweHSxc3nzJGF{e2G7 NGG2fFA2KM7:TR?= MX[yOEBp NIW1OVRFVVOR NFvDPHNKdmS3Y3XzJIFxd3C2b4TpZ{Bk\WyuIHTlZZRp MlTHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5OUK4NVEoRjJ3N{myPFEyRC:jPh?=
U-2 OS MVXGeY5kfGmxbjDBd5NigQ>? M1\ufFUh|ryP MnrxNlQhcA>? MkTHSG1UVw>? MkHZVJJwdW:2ZYOgZZV1d3CqYXfpZ{Bk\WyuIHTlZZRp MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd7MkixNUc,OjV5OUK4NVE9N2F-
MG-63 NWPmZpQ{TnWwY4Tpc44hSXO|YYm= NHXvTnY2KM7:TR?= MkXKNlQhcA>? Ml\WSG1UVw>? NWX1RYRkWHKxbX;0[ZMh[XW2b4DoZYdq[yClZXzsJIRm[XSq MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd7MkixNUc,OjV5OUK4NVE9N2F-
PANC-1 NV3qZoVsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXrZYtJPTBizszN NUDscoV7OjRiaB?= M{XaN2ROW09? NFPLbo5KSzVyPUeuNUDPxE1? M37V[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkOyNlI2Lz5{NU[zNlIzPTxxYU6=
BxPC-3 NGP6RVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfweGE2OCEQvF2= MmPoNlQhcA>? Mle1SG1UVw>? MoSwTWM2OD14Lkig{txO MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ|MkKyOUc,OjV4M{KyNlU9N2F-
PANC-1 NGG2RXBHfW6ldHnvckBCe3OjeR?= NEHXcYY2KM7:TR?= NUeyVG1{OjRiaB?= M4TmRWROW09? MX\JcoR2[2W|IHPlcIwh[3mlbHWgZZJz\XO2IHnuJGczN01icHjhd4U> NV61Nld4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2N|IzOjVpPkK1OlMzOjJ3PD;hQi=>
BxPC-3 MVPGeY5kfGmxbjDBd5NigQ>? MVW1JO69VQ>? NFzOXHEzPCCq MYLEUXNQ NVLIU2VjUW6mdXPld{Bk\WyuIHP5Z4xmKGG{cnXzeEBqdiCJMj;NJJBp[XOn NFHMOlY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[zNlIzPSd-MkW2N|IzOjV:L3G+
PANC-1 MXXGeY5kfGmxbjDBd5NigQ>? MUG1JO69VQ>? MkfhNlQhcA>? M{faRmROW09? NIrFdmJKdmS3Y3XzJIF2fG:yaHHnbYMh[2WubDDk[YF1cA>? NVzKVo46RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2N|IzOjVpPkK1OlMzOjJ3PD;hQi=>
BxPC-3 MYXGeY5kfGmxbjDBd5NigQ>? MX61JO69VQ>? MoL1NlQhcA>? NHnMTIFFVVOR NEGwc2RKdmS3Y3XzJIF2fG:yaHHnbYMh[2WubDDk[YF1cA>? NUOz[Ws2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2N|IzOjVpPkK1OlMzOjJ3PD;hQi=>
SKOV3 NYnSfmd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvLNVAxKM7:TR?= M2TzXVI1KGh? M363cmROW09? M2KyWmlEPTB;MkCuOFgh|ryP NUm4XoF1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2NlQ4PTBpPkK1OlI1PzVyPD;hQi=>
OVCAR4 MmLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLlbFcxOTByIN88US=> Mo\yNlQhcA>? M2XYbGROW09? NVPi[GtjUUN3ME2yNk4yOyEQvF2= NYPTVW5xRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2NlQ4PTBpPkK1OlI1PzVyPD;hQi=>
SKOV3 Mof0SpVv[3Srb36gRZN{[Xl? NF76SI82KM7:TR?= M{TublczKGh? NXjOTVlpTE2VTx?= MmrWTY5lfWOnczDHNk9OKGG{cnXzeC=> M2HMS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkK0O|UxLz5{NU[yOFc2ODxxYU6=
OVCAR4 NFOzdmNHfW6ldHnvckBCe3OjeR?= MYm1JO69VQ>? NEGye2c4OiCq NGfGPItFVVOR NF;IcWRKdmS3Y3XzJGczN01iYYLy[ZN1 Mkm4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4MkS3OVAoRjJ3NkK0O|UxRC:jPh?=
SKOV3 MYrBdI9xfG:|aYOgRZN{[Xl? M4LWfVUh|ryP MlfBNlQhcA>? MW\EUXNQ Mn\5TY5lfWOnczDhdI9xfG:|aYO= MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ{NEe1NEc,OjV4MkS3OVA9N2F-
OVCAR4 NYD2fpVxSXCxcITvd4l{KEG|c3H5 MoO2OUDPxE1? NGXZPI0zPCCq NInlXJlFVVOR MX;JcoR2[2W|IHHwc5B1d3Orcx?= NXiz[5d{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2NlQ4PTBpPkK1OlI1PzVyPD;hQi=>
AGS NFS4bGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrjcYFJOjVizszN M2DRWFI1KGh? M4HKU2ROW09? MX;JR|UxRTF7LkC5JO69VQ>? M13oUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkC5PVI{Lz5{NU[wPVkzOzxxYU6=
NCI-N78 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2f5UlI2KM7:TR?= NVnn[FNOOjRiaB?= NGXHVWJFVVOR MUXJR|UxRTJ4LkOzJO69VQ>? MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZyOUmyN{c,OjV4MEm5NlM9N2F-
AGS MXTBdI9xfG:|aYOgRZN{[Xl? NIfPOYQ2KM7:TR?= NWrrUG9jOjRiaB?= NVLBWYY{TE2VTx?= M2THe2lv\HWlZYOgZZBweHSxc3nz M2m2ZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkC5PVI{Lz5{NU[wPVkzOzxxYU6=
NCI-N78 M1XvbmFxd3C2b4Ppd{BCe3OjeR?= NIPDOYY2KM7:TR?= M4r1VFI1KGh? MXzEUXNQ MVnJcoR2[2W|IHHwc5B1d3Orcx?= MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZyOUmyN{c,OjV4MEm5NlM9N2F-
AGS MnzOSpVv[3Srb36gRZN{[Xl? M2TOfVUh|ryP MWWyOEBp MUDEUXNQ MUjJcoR2[2W|IITo[UBifXSxcHjh[5k> NXrlPVhQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2NFk6OjNpPkK1OlA6QTJ|PD;hQi=>
NCI-N78 NIfpTHBHfW6ldHnvckBCe3OjeR?= NE[0SJg2KM7:TR?= NEf0W2UzPCCq MUXEUXNQ NVz3OpFoUW6mdXPld{B1cGViYYX0c5Bp[We7 MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZyOUmyN{c,OjV4MEm5NlM9N2F-
HSC-3 NEjlVJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILzdGIyKM7:TR?= MVq0PEBp MYXJR|UxRTBwNUSg{txO MlnEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV|Nk[xOFMoRjJ3M{[2NVQ{RC:jPh?=
GB30 Mnr3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1:1U|Eh|ryP NGWwV3U4KGR? Mn3oSG1UVw>? MVvJR|UxRTBwMEGxJO69VQ>? MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTFyNkSyPEc,OjVzME[0Nlg9N2F-
GB9 NVi0UI84T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1SwOlEh|ryP MX:3JIQ> NE[3PGxFVVOR MoDZTWM2OD1yLkCyOEDPxE1? M1;se|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MUC2OFI5Lz5{NUGwOlQzQDxxYU6=
GB169 NVzzfHFjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7vdGYyKM7:TR?= MV:3JIQ> NIf5bGhFVVOR NEHF[IVKSzVyPUCuNFMzKM7:TR?= NHLLVFI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUGwOlQzQCd-MkWxNFY1Ojh:L3G+
T24 M{TjTGZ2dmO2aX;uJGF{e2G7 Mn6yNUDPxE1? NVvNVlM6PDhiaB?= MoDNSG1UVw>? M2DwR2lv\HWlZYOgZ4VtdCCleXPs[UBienKnc4S= MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzRyM{[zN{c,OjN2MEO2N|M9N2F-
RT4 MUXGeY5kfGmxbjDBd5NigQ>? MknSNUDPxE1? NUTiTFF7PDhiaB?= MofwSG1UVw>? MVnJcoR2[2W|IHPlcIwh[3mlbHWgZZJz\XO2 NXm1WlhWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0NFM3OzNpPkKzOFA{PjN|PD;hQi=>
UM-UC-3 NIrqeZpHfW6ldHnvckBCe3OjeR?= M3LHbVEh|ryP M2PM[lQ5KGh? NXjWW|NtTE2VTx?= M13pd2lv\HWlZYOgZ4VtdCCleXPs[UBienKnc4S= M3q3WlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NECzOlM{Lz5{M{SwN|Y{OzxxYU6=
T24 NFzSW4VCeG:ydH;zbZMhSXO|YYm= MYezMlE3KM7:TR?= MlP0PVYhcA>? NWflbZRTTE2VTx?= Mni1TWM2OD1yLkCzNFYh|ryP M2m4[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NECzOlM{Lz5{M{SwN|Y{OzxxYU6=
RT4 M3S3dGFxd3C2b4Ppd{BCe3OjeR?= Mn7iN{4yPiEQvF2= NW\M[4xDQTZiaB?= Mn7BSG1UVw>? NIDXOmxKSzVyPUCuNVE6QCEQvF2= MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzRyM{[zN{c,OjN2MEO2N|M9N2F-
UM-UC-3 M3vlTGFxd3C2b4Ppd{BCe3OjeR?= MojzN{4yPiEQvF2= NHfsVWg6PiCq NW\ofmZOTE2VTx?= MmrkTWM2OD1yLkC0OFkh|ryP NXn4doNtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0NFM3OzNpPkKzOFA{PjN|PD;hQi=>
OVCAR-5 NHvlfHJHfW6ldHnvckBCe3OjeR?= M2G4XVUxKG6P NITXN3FKdmirYnn0d{Bk\WyuIH3p[5JifGmxbh?= NIntbIM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OzOFMzPyd-MkOzN|Q{Ojd:L3G+
SKOV3ip2 Ml;nSpVv[3Srb36gRZN{[Xl? MYS1NEBvVQ>? M3zkdGlvcGmkaYTzJINmdGxibXnndoF1cW:w NUi3UnF3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzN|Q{OjdpPkKzN|M1OzJ5PD;hQi=>
S462 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PiTFExOCEQvF2= MmLMO|IhcA>? MnjvSG1UVw>? M4LEfWF1fGWwdXH0[ZMh[2WubDDndo94fGh? MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzN{OEGxOEc,OjN|MkixNVQ9N2F-
2884 MmjBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{L0WFExOCEQvF2= MWG3NkBp MX7EUXNQ MVLBeJRmdnWjdHXzJINmdGxiZ4Lve5Rp MnyzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MkixNVQoRjJ|M{K4NVE1RC:jPh?=
2885 NVrLNGh1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nNTlExOCEQvF2= MonaO|IhcA>? NXr2RmY3TE2VTx?= NIj2ZVJCfHSnboXheIV{KGOnbHyg[5Jwf3Sq M17ucFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{K4NVE1Lz5{M{OyPFEyPDxxYU6=
CRL-2396 M3XrWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHYNVAxKM7:TR?= MX\3ZZRmeg>? NH61TldKSzVyPUCuNFkzKM7:TR?= MlnSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNzNUO1NlQoRjJ|MUWzOVI1RC:jPh?=
TIB-48 M1H4[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUWxNFAh|ryP M2H0VZdifGW{ MmPkTWM2OD1yLkC4PEDPxE1? Ml;jQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNzNUO1NlQoRjJ|MUWzOVI1RC:jPh?=
CRL-2396 MlHqR5l1d3SxeHnjJGF{e2G7 M12yUFEh|ryP NYjCOJJ{PDhiaB?= M1HWb5difGW{ M3HKWWlv\HWlZYOgZZBweHSxc3nz NXy0cWtqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOxOVM2OjRpPkKzNVU{PTJ2PD;hQi=>
TIB-48 MlvNR5l1d3SxeHnjJGF{e2G7 MVexJO69VQ>? NF7kb5Y1QCCq MkPje4F1\XJ? MX\JcoR2[2W|IHHwc5B1d3Orcx?= NUnafXdrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOxOVM2OjRpPkKzNVU{PTJ2PD;hQi=>
AGS NEDDZWxEgXSxdH;4bYMhSXO|YYm= MlXFNE42KM7:TR?= NIfMXIozPCCq NVHKVIxVTE2VTx?= NYTlR3V2TGWlcnXhd4V{KGOnbHygd5Vzfmm4YXy= NWPkXHZXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK5O|I3OTFpPkKyPVczPjFzPD;hQi=>
FLO-1 MVzDfZRwfG:6aXOgRZN{[Xl? MmqxNE42KM7:TR?= NWLqXYVOOjRiaB?= NFm2WWpFVVOR NYXGcXpLTGWlcnXhd4V{KGOnbHygd5Vzfmm4YXy= MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl5Mk[xNUc,OjJ7N{K2NVE9N2F-
OE33 NHnGXnVEgXSxdH;4bYMhSXO|YYm= NELpZnkxNjVizszN M3i1PVI1KGh? NHPWbWFFVVOR MnrGSIVkemWjc3XzJINmdGxic4Xyeol3[Wx? MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl5Mk[xNUc,OjJ7N{K2NVE9N2F-
SKLMS M{LKe2N6fG:2b4jpZ{BCe3OjeR?= NE\tdJU4PSCwTR?= NWfGdXl{QTZiaB?= MkjvTY5lfWOnczDhdI9xfG:|aYO= NV;W[JFCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4NlE6QTdpPkKyPFIyQTl5PD;hQi=>
Leio285 NXvMO49SS3m2b4TvfIlkKEG|c3H5 M4nwZVc2KG6P NV;uVWt[QTZiaB?= NWL1PGpxUW6mdXPld{BieG:ydH;zbZM> NGG1ZnM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkiyNVk6Pyd-MkK4NlE6QTd:L3G+
Mes-Sa M33mfGN6fG:2b4jpZ{BCe3OjeR?= NFPzXJA4PSCwTR?= NVvRdZNrQTZiaB?= M{LoPWlv\HWlZYOgZZBweHSxc3nz Ml20QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6MkG5PVcoRjJ{OEKxPVk4RC:jPh?=
DAOY NELNWYhEgXSxdH;4bYMhSXO|YYm= NIq5dWUyOCEQvF2= MUi3NkBp M4DBSGROW09? Ml\2TWM2OD1yLkC0JO69VQ>? NV:2fWY1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK2Olk{OzVpPkKyOlY6OzN3PD;hQi=>
IMR32 MWDDfZRwfG:6aXOgRZN{[Xl? NGXab5YyOCEQvF2= MXu3NkBp NXL6VWM1TE2VTx?= M3TSOmlEPTB;MD6wN{DPxE1? NVyzPZpFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK2Olk{OzVpPkKyOlY6OzN3PD;hQi=>
Molt-4 M{HsbWN6fG:2b4jpZ{BCe3OjeR?= NX3Kc5B4OTBizszN MknMO|IhcA>? NH7lPYJFVVOR MYfJR|UxRTBwMEKg{txO Mmr4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ4NkmzN|UoRjJ{Nk[5N|M2RC:jPh?=
MOLM-13 NIXtRohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUi0NHhFOyEQvF2= MWm3NkBp NXSzTZpiTGmvaX7pd4hmeyClZXzsJJZq[WKrbHn0fS=> MknNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2OEiyOFkoRjJ{NEi4NlQ6RC:jPh?=
HL-60 NH[0WHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XCbFMh|ryP MVe3NkBp M2LrbGRqdWmwaYPo[ZMh[2WubDD2bYFjcWyrdIm= Mn23QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2OEiyOFkoRjJ{NEi4NlQ6RC:jPh?=
MV4-11 M2DsXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLDN{DPxE1? MX[3NkBp NHfiUlhFcW2rbnnzbIV{KGOnbHygeoli[mmuaYT5 NUj0UYd6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0PFgzPDlpPkKyOFg5OjR7PD;hQi=>
SKM-1 NY\oUW9NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\nN{DPxE1? MmjUO|IhcA>? MWLEbY1qdmm|aHXzJINmdGxidnnhZoltcXS7 MmLyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2OEiyOFkoRjJ{NEi4NlQ6RC:jPh?=
SH2 NX7FflhkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFyxOm4{KM7:TR?= M3\nc|czKGh? NYjETmxVTGmvaX7pd4hmeyClZXzsJJZq[WKrbHn0fS=> M4rlUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEi4NlQ6Lz5{MkS4PFI1QTxxYU6=
NOMO-1 NWriSotsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXRZWtNOyEQvF2= Mn;sO|IhcA>? NWP1SY92TGmvaX7pd4hmeyClZXzsJJZq[WKrbHn0fS=> NETjVnQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkS4PFI1QSd-MkK0PFgzPDl:L3G+
OCL-AML2 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fmUFMh|ryP NGrQRo04OiCq M{jEWGRqdWmwaYPo[ZMh[2WubDD2bYFjcWyrdIm= M{XI[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEi4NlQ6Lz5{MkS4PFI1QTxxYU6=
PL-21 NWnCSFZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1ra[|Mh|ryP MX23NkBp MV\EbY1qdmm|aHXzJINmdGxidnnhZoltcXS7 NGTVbGQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkS4PFI1QSd-MkK0PFgzPDl:L3G+
KG-1 M4PQVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnqZlc{KM7:TR?= M4q5[VczKGh? MVvEbY1qdmm|aHXzJINmdGxidnnhZoltcXS7 MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR6OEK0PUc,OjJ2OEiyOFk9N2F-
A172 MYTDfZRwfG:6aXOgRZN{[Xl? MlXONVAxKM7:TR?= M3;0dVI1KGh? NHXxfGZFVVOR M{XxSWlEPTB;MD6xNlAh|ryP MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJ5NEO5PUc,OjJ{N{SzPVk9N2F-
U87 MVjDfZRwfG:6aXOgRZN{[Xl? M3nlW|ExOCEQvF2= NELDVlczPCCq NX:zPYVRTE2VTx?= MnW3TWM2OD1yLkGwOUDPxE1? NWPsenc{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyO|Q{QTlpPkKyNlc1Ozl7PD;hQi=>
U251 MnfCR5l1d3SxeHnjJGF{e2G7 NGLCNIEyODBizszN M2nTSlI1KGh? NFe4OFFFVVOR NEnKWmZKSzVyPUCuNVAxKM7:TR?= NHnLcpU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkK3OFM6QSd-MkKyO|Q{QTl:L3G+
T98 NYPkb45SS3m2b4TvfIlkKEG|c3H5 MVixNFAh|ryP MWCyOEBp MkHxSG1UVw>? MXrJR|UxRTBwMUK1JO69VQ>? Mkm5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{N{SzPVkoRjJ{Mke0N|k6RC:jPh?=
LN18 NXn6PYdZS3m2b4TvfIlkKEG|c3H5 NYTTRYtIOTByIN88US=> NUDwc3FxOjRiaB?= NHG4ZYJFVVOR M3j0VmlEPTB;MD6yNVAh|ryP M3nwNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{Mke0N|k6Lz5{MkK3OFM6QTxxYU6=
LN443 MkPxR5l1d3SxeHnjJGF{e2G7 M3TrTFExOCEQvF2= MVSyOEBp NXy3VnNoTE2VTx?= NWjNWW95UUN3ME2wMlIzOCEQvF2= MmfLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{N{SzPVkoRjJ{Mke0N|k6RC:jPh?=
HF66 MV;DfZRwfG:6aXOgRZN{[Xl? MWGxNFAh|ryP NE\NWVIzPCCq MYnEUXNQ NHzvT5RKSzVyPUCuNlI2KM7:TR?= MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJ5NEO5PUc,OjJ{N{SzPVk9N2F-
HF2303 MYXDfZRwfG:6aXOgRZN{[Xl? Mn;kNVAxKM7:TR?= NGrKVYMzPCCq MnfHSG1UVw>? NHPGUVhKSzVyPUCuNFYxKM7:TR?= MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJ5NEO5PUc,OjJ{N{SzPVk9N2F-
HF2359 NXL2dINUS3m2b4TvfIlkKEG|c3H5 M2[0W|ExOCEQvF2= NWqxNIxDOjRiaB?= NWLpOFJ1TE2VTx?= NGWzd5FKSzVyPUCuNFYxKM7:TR?= NILzR289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkK3OFM6QSd-MkKyO|Q{QTl:L3G+
HF2414 M3TNd2N6fG:2b4jpZ{BCe3OjeR?= MoHwNVAxKM7:TR?= MkTHNlQhcA>? NGHjcZBFVVOR NX3zW|JYUUN3ME2wMlA5OCEQvF2= NFfPR|c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkK3OFM6QSd-MkKyO|Q{QTl:L3G+
A-673 MmTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDqR5EyOCEQvF2= NWS3Vox4QTZiaB?= NX;IVpZ3TE2VTx?= NHLsVpVKSzVyPUCuNFMzKM7:TR?= M1XoVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNES4OVkyLz5{MUS0PFU6OTxxYU6=
TC-32 MnHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVOxNEDPxE1? M2jW[Fk3KGh? M{PlS2ROW09? MYXJR|UxRTBwMEO5JO69VQ>? M3[yT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNES4OVkyLz5{MUS0PFU6OTxxYU6=
TC-71 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHT1fWwyOCEQvF2= NHG3boM6PiCq M2TzTGROW09? NF;qdGNKSzVyPUCuNVAzKM7:TR?= NXjIN3FURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0OFg2QTFpPkKxOFQ5PTlzPD;hQi=>
SK-N-MC M{nWW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzpUlQyOCEQvF2= NIrneI86PiCq MV\EUXNQ M1XsfWlEPTB;MD6wO|Ih|ryP NVKxOW9DRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0OFg2QTFpPkKxOFQ5PTlzPD;hQi=>
CHLA-9 M1P4Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zJbFExKM7:TR?= MkT2PVYhcA>? MljrSG1UVw>? M1\PSWlEPTB;MD6wNVgh|ryP M1ns[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNES4OVkyLz5{MUS0PFU6OTxxYU6=
CHLA-10 MmHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moj1NVAh|ryP M2TybFk3KGh? NXTvepVRTE2VTx?= MoXvTWM2OD1yLkC2NEDPxE1? Mn;CQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2NEi1PVEoRjJzNES4OVkyRC:jPh?=
CHLA-25 NWS2SGxpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTyb|UyOCEQvF2= MmjkPVYhcA>? MVzEUXNQ MUPJR|UxRTBwMU[4JO69VQ>? NVjj[Vg{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0OFg2QTFpPkKxOFQ5PTlzPD;hQi=>
CHLA-32 NUnGeYZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljkNVAh|ryP M1zWe|k3KGh? NXTaUINGTE2VTx?= Mn7xTWM2OD1yLkGzOkDPxE1? NIPTO2s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUS0PFU6OSd-MkG0OFg2QTF:L3G+
CHLA-56 NIHxS3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7uNVAh|ryP MWW5OkBp Ml72SG1UVw>? NV\1XGs{UUN3ME2xNEDPxE1? NXuwbWRFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0OFg2QTFpPkKxOFQ5PTlzPD;hQi=>
CHLA-258 MlXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojRNVAh|ryP M{\F[lk3KGh? NHXtboJFVVOR MYDJR|UxRTBwMUOyJO69VQ>? NX;DcmE3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0OFg2QTFpPkKxOFQ5PTlzPD;hQi=>
COG-E-352 M3vtZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjvXpQyOCEQvF2= NHjISJc6PiCq NI\sNW1FVVOR NGe5ZWJKSzVyPUCuNFQ{KM7:TR?= Ml;uQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2NEi1PVEoRjJzNES4OVkyRC:jPh?=
CHLA-90 M1jnUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jFPVExKM7:TR?= MX65OkBp M3nTOWROW09? M2K3SmlEPTB;MD6wOlEh|ryP NGr3O3c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUS0PFU6OSd-MkG0OFg2QTF:L3G+
CHLA-119 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXyxNEDPxE1? NH;jWYI6PiCq NUjBfW5oTE2VTx?= MnnoTWM2OD1yLkCyNkDPxE1? NXj1e|FDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0OFg2QTFpPkKxOFQ5PTlzPD;hQi=>
CHLA-122 Mne5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUixNEDPxE1? MnrlPVYhcA>? M1zBRmROW09? MXHJR|UxRTBwMEG5JO69VQ>? NHrVR5E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUS0PFU6OSd-MkG0OFg2QTF:L3G+
CHLA-136 NWjNVJFGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4O2WVExKM7:TR?= NGXHXpQ6PiCq MlnBSG1UVw>? MmjFTWM2OD1yLkCzPUDPxE1? M4rPRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNES4OVkyLz5{MUS0PFU6OTxxYU6=
CHLA-140 NVzURYR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPtN2JsOTBizszN NIXIV3I6PiCq MWXEUXNQ M4nkSWlEPTB;MD6wNlYh|ryP MnLxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2NEi1PVEoRjJzNES4OVkyRC:jPh?=
LA-N-6 NEO4UXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HQb|ExKM7:TR?= M1HlO|k3KGh? NEHqSFJFVVOR NVz4SGVDUUN3ME2wMlA2PCEQvF2= MlvyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2NEi1PVEoRjJzNES4OVkyRC:jPh?=
NB-1643 MnfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4r4WVExKM7:TR?= MYq5OkBp NUX5fFNqTE2VTx?= NYK0d3RKUUN3ME2wMlA{PyEQvF2= NIjuN|Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUS0PFU6OSd-MkG0OFg2QTF:L3G+
NB-EBc1 NF7CO3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonMNVAh|ryP NHvX[XU6PiCq MUjEUXNQ MUXJR|UxRTBwMEWwJO69VQ>? NWXaUlFvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0OFg2QTFpPkKxOFQ5PTlzPD;hQi=>
SK-N-BE-1 M2HoUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY[xNEDPxE1? M3rWO|k3KGh? NFrEdJpFVVOR MXzJR|UxRTBwMEK4JO69VQ>? NHHPXlk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUS0PFU6OSd-MkG0OFg2QTF:L3G+
SK-N-BE-2 NY[xVlliT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPzfWYyOCEQvF2= NHPERpM6PiCq NUPYUoRQTE2VTx?= M{LvdGlEPTB;MD6wN|Yh|ryP MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTR2OEW5NUc,OjF2NEi1PVE9N2F-
SMS-KAN M1\iRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDPWI4yOCEQvF2= MVO5OkBp M1T2cWROW09? NWD4ZnY{UUN3ME2wMlA{PCEQvF2= NX;5dZdZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0OFg2QTFpPkKxOFQ5PTlzPD;hQi=>
SMS-KANR NWXYc29uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnjfmpIOTBizszN Mn7EPVYhcA>? MofOSG1UVw>? M{jpfWlEPTB;MD6wNlYh|ryP NEX6V5U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUS0PFU6OSd-MkG0OFg2QTF:L3G+
SMS-KCN M3zZfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PXT|ExKM7:TR?= NUjST3RnQTZiaB?= MVXEUXNQ NH7pSlhKSzVyPUCuNFE6KM7:TR?= M4jjd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNES4OVkyLz5{MUS0PFU6OTxxYU6=
SMS-KCNR M{PEVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkP3NVAh|ryP MX25OkBp NGnuUJhFVVOR Mk\ITWM2OD1yLkCxNEDPxE1? MnHQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2NEi1PVEoRjJzNES4OVkyRC:jPh?=
SMS-LHN MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV2xNEDPxE1? MmrGPVYhcA>? NI\uVZJFVVOR NEXvR5VKSzVyPUCuNFMzKM7:TR?= NVrCVJg2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0OFg2QTFpPkKxOFQ5PTlzPD;hQi=>
SMS-MSN NXrpe3N3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;2cpcyOCEQvF2= MUe5OkBp NWPQemJDTE2VTx?= M2rMcGlEPTB;MD6wNlIh|ryP MnzrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2NEi1PVEoRjJzNES4OVkyRC:jPh?=
SMS-SAN NHfsSGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYWxNEDPxE1? MYS5OkBp Moj5SG1UVw>? NHrs[W9KSzVyPUCuNFIxKM7:TR?= NXLVSVVuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0OFg2QTFpPkKxOFQ5PTlzPD;hQi=>
Granta-4 NGfNVZhEgXSxdH;4bYMhSXO|YYm= M4\FWlExKM7:TR?= M33EVFch\A>? MY\JR|UxRTBwMESwJO69VQ>? M1PUW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMkmxPFY4Lz5{MUK5NVg3PzxxYU6=
DB MX;DfZRwfG:6aXOgRZN{[Xl? MWKxNEDPxE1? MYq3JIQ> Mm\4TWM2OD1yLkC0NkDPxE1? M3viTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMkmxPFY4Lz5{MUK5NVg3PzxxYU6=
RL NVK2elJQS3m2b4TvfIlkKEG|c3H5 NX;KXpl1OTBizszN NYH0Ro5[PyCm NYq3VlNyUUN3ME2wMlAyPSEQvF2= NWrUXJRtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGyPVE5PjdpPkKxNlkyQDZ5PD;hQi=>
K562 NYfFcnNwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXmxNEDPxE1? MWq5OkBp MmK2TWM2OD1yLkC4O{DPxE1? NEC0WFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUC5NVY{Oyd-MkGwPVE3OzN:L3G+
LAMA-84 M3j3NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfwNVAh|ryP M1;vS|k3KGh? MYLJR|UxRTBwMEW3JO69VQ>? MojDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFyOUG2N|MoRjJzMEmxOlM{RC:jPh?=
MM15 NF7nO5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\VOEDPxE1? NHzBXIE4OiCq MnztSG1UVw>? Moj2TWM2OD1yLkGzJO69VQ>? Mo\rQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB|OEK4OFQoRjJyM{iyPFQ1RC:jPh?=
OPM1 NXfZO2E{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TRZ|Qh|ryP Mn75O|IhcA>? Mlf6SG1UVw>? NF;DOZBKSzVyPUCuNFMh|ryP NY\LVVZRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzPFI5PDRpPkKwN|gzQDR2PD;hQi=>
RPM1 NVXqfIRET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1roSVQh|ryP MVu3NkBp NVPxUFNtTE2VTx?= MmrSTWM2OD1zMD6zNkDPxE1? NVrQPFlpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzPFI5PDRpPkKwN|gzQDR2PD;hQi=>
INA6 MlL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTHOEDPxE1? M{\UTlczKGh? NXPLbHlFTE2VTx?= M1nJRmlEPTB;MD6wNFIh|ryP M1vLPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{iyPFQ1Lz5{MEO4Nlg1PDxxYU6=
OPM2 NVi4U3J1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDjV3Y1KM7:TR?= NW[1eZE6PzJiaB?= NHPuSGJFVVOR M2CwVWlEPTB;ND6zO{DPxE1? MliwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB|OEK4OFQoRjJyM{iyPFQ1RC:jPh?=
MM1R NHrPTG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnt[IM1KM7:TR?= M{mwNVczKGh? MYHEUXNQ M3LZcmlEPTB;MT62PEDPxE1? MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODN6Mki0OEc,OjB|OEK4OFQ9N2F-
DOX40 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nRdFQh|ryP M{XPb|czKGh? NICyRnNFVVOR MX\JR|UxRTVwNEig{txO MlPhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB|OEK4OFQoRjJyM{iyPFQ1RC:jPh?=
LR5 NWHjT2s{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXi0JO69VQ>? NW\1NFZvPzJiaB?= NH[zS2xFVVOR M1vz[WlEPTB;Mj61N{DPxE1? MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODN6Mki0OEc,OjB|OEK4OFQ9N2F-
U266 Ml;rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDROEDPxE1? MkLJO|IhcA>? NHjoOFNFVVOR MmLzTWM2OD1zLkSzJO69VQ>? NVLIVXhiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzPFI5PDRpPkKwN|gzQDR2PD;hQi=>
RD NHPyOXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHITJZVOTBizszN Mn22PVYhcA>? NFLSdo9KSzVyPUCuNlI5KM7:TR?= NUfEbYtTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxNFg{OzhpPkKwNVA5OzN6PD;hQi=>
Rh41 NVXoXWo2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHMWYgyOCEQvF2= NIC5eGk6PiCq NFTsPXdKSzVyPUCuNFkxKM7:TR?= NH7BU2I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEGwPFM{QCd-MkCxNFg{Ozh:L3G+
Rh30 NHXFVFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHi5dokyOCEQvF2= NWeyfFBrQTZiaB?= MXrJR|UxRTBwMkOwJO69VQ>? MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODFyOEOzPEc,OjBzMEizN|g9N2F-
BT-12 MmfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYKxNEDPxE1? M2DoV|k3KGh? MXfJR|UxRTBwME[wJO69VQ>? NFXLcWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEGwPFM{QCd-MkCxNFg{Ozh:L3G+
CHLA-266 M4Dhfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{T6VVExKM7:TR?= MVy5OkBp Mlu1TWM2OD1yLkC3NkDPxE1? MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODFyOEOzPEc,OjBzMEizN|g9N2F-
TC-71 NVXNN3dlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33rT|ExKM7:TR?= NEe4R4I6PiCq Ml;1TWM2OD1yLkGwNkDPxE1? M3zZcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUC4N|M5Lz5{MEGwPFM{QDxxYU6=
SJ-GBM2 MoezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\iVVUyOCEQvF2= NVHxZ|RbQTZiaB?= MnP0TWM2OD1yLkC1NEDPxE1? MnvXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzMEizN|goRjJyMUC4N|M5RC:jPh?=
NALM-6 MnX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfJNVAh|ryP M3O4eVk3KGh? NXnQTox7UUN3ME2wMlA3OiEQvF2= M3L1W|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUC4N|M5Lz5{MEGwPFM{QDxxYU6=
COG-LL-317 M37hVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLzcpBIOTBizszN MmnIPVYhcA>? MojNTWM2OD1yLkC0O{DPxE1? NYnqWGxYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxNFg{OzhpPkKwNVA5OzN6PD;hQi=>
RS4-11 NFq2emdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVSxNEDPxE1? NYe1[Gl1QTZiaB?= MoX1TWM2OD1yLkCxPEDPxE1? MlLZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzMEizN|goRjJyMUC4N|M5RC:jPh?=
MOLT-4 NVf0OHpFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTmNVAh|ryP NInHW2c6PiCq NGfxNmRKSzVyPUCuNFI3KM7:TR?= NVPHeVFoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxNFg{OzhpPkKwNVA5OzN6PD;hQi=>
CCRF-CEM NIrmTWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWOxNEDPxE1? Mn23PVYhcA>? M1;3U2lEPTB;MD6wPVQh|ryP MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODFyOEOzPEc,OjBzMEizN|g9N2F-
Kasumi-1 Mk\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\jSIszOTBizszN NI\1cmg6PiCq MoL5TWM2OD1yLkGwN{DPxE1? M2jCbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUC4N|M5Lz5{MEGwPFM{QDxxYU6=
Karpas-299 MkCzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHONVAh|ryP M4K5Wlk3KGh? NFW3UotKSzVyPUCuNFM5KM7:TR?= NVPXfHY6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxNFg{OzhpPkKwNVA5OzN6PD;hQi=>
Ramos-RA1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzrOXpNOTBizszN NVe3UY43QTZiaB?= MYfJR|UxRTBwMUK3JO69VQ>? NYXZUGV4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxNFg{OzhpPkKwNVA5OzN6PD;hQi=>
GSS M1rLRmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 Mlq2O|IhcHK| M3vkc2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iR2PTJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCZU2S4JIF{e2G7LDDJR|UxKD1iMD6wN|kh|ryPLh?= NVL2dlZCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2NlU3OTdpPkK1OlI2PjF5PD;hQi=>
LU99A NGXBe|VCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MXO3NkBpenN? Mnf2RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCOVUm5RUBk\WyuczDh[pRmeiB5MjDodpMh[nliV2PUPEBie3OjeTygTWM2OCB;IECuNFYzKM7:TT6= MnjMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4MkW2NVcoRjJ3NkK1OlE4RC:jPh?=
HL60 NHTXXZRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MlLOO|IhcHK| M1f5OGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFy2NEBk\WyuczDh[pRmeiB5MjDodpMh[nliV2PUPEBie3OjeTygTWM2OCB;IECuNFc1KM7:TT6= Mn3rQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4MkW2NVcoRjJ3NkK1OlE4RC:jPh?=
LC2/ad MWfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MkDqO|IhcHK| NGnNN2JCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFzDNk9i\CClZXzsd{Bi\nSncjC3NkBpenNiYomgW3NVQCCjc4PhfUwhUUN3MDC9JFAvODd5IN88UU4> MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ{NU[xO{c,OjV4MkW2NVc9N2F-
MKN45 M3\qUmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M17OSlczKGi{cx?= MULBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2NTkS1JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCZU2S4JIF{e2G7LDDJR|UxKD1iMD6wPVMh|ryPLh?= NFn5[o49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[yOVYyPyd-MkW2NlU3OTd:L3G+
HCT116 MYnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NWi0TmtIPzJiaILz MXLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEGxOkBk\WyuczDh[pRmeiB5MjDodpMh[nliV2PUPEBie3OjeTygTWM2OCB;IECuNFk2KM7:TT6= M1LiW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkK1OlE4Lz5{NU[yOVYyPzxxYU6=
Lu116 M2TOfmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M1fRflczKGi{cx?= M2\nWGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTIWxNVYh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IGfTWFgh[XO|YYmsJGlEPTBiPTCwMlA6PyEQvF2u M4KzPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkK1OlE4Lz5{NU[yOVYyPzxxYU6=
NCI-H358 MUnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? Mn\mO|IhcHK| Mm[2RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCQQ1mtTFM2QCClZXzsd{Bi\nSncjC3NkBpenNiYomgW3NVQCCjc4PhfUwhUUN3MDC9JFAvOSEQvF2u M{T0XVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkK1OlE4Lz5{NU[yOVYyPzxxYU6=
MIAPaCa2 NVPQU4tGSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MYG3NkBpenN? M2npfmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVnBVIFE[TJiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JHdUXDhiYYPzZZktKEmFNUCgQUAxNjF|IN88UU4> NIS2fFg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[yOVYyPyd-MkW2NlU3OTd:L3G+
PC14 MYTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NHv3d404OiCqcoO= MnnoRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCSQ{G0JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCZU2S4JIF{e2G7LDDJR|UxKD1iMD6xO{DPxE1w Mn7IQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4MkW2NVcoRjJ3NkK1OlE4RC:jPh?=
HT-29 MUnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MUe3NkBpenN? NFPpZ2hCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjUMVI6KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDXV3Q5KGG|c3H5MEBKSzVyIE2gNE4{OyEQvF2u MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ{NU[xO{c,OjV4MkW2NVc9N2F-
HCT15 MXvBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NF7ER2c4OiCqcoO= MmHSRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ2SxOUBk\WyuczDh[pRmeiB5MjDodpMh[nliV2PUPEBie3OjeTygTWM2OCB;IECuO|Qh|ryPLh?= NIjESWw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[yOVYyPyd-MkW2NlU3OTd:L3G+
Sf9 NXzOT|BWTnWwY4Tpc44h[XO|YYm= M3\oOGNwdXCndHn0bZZmKGmwaHnibZRqd25ib3[gdoVkd22kaX7hcpQhdW:3c3WgZZVzd3KjIHvpcoF{\SCDIHX4dJJme3OnZDDpckBqdnOnY4SgV4Y6KGOnbHzzJIlvKHC{ZYPlcoNmKG:oIFHUVEwhU2liPTCwMlAxODNizszNMi=> NYnl[3Z6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xNFE2PjRpPkK2NVAyPTZ2PD;hQi=>
Sf9 NYTCelZxTnWwY4Tpc44h[XO|YYm= MV\Jcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IH3veZNmKGG3cn;yZUBscW6jc3WgRUBmgHC{ZYPz[YQhcW5iaX7z[YN1KFOoOTDj[YxteyC3c3nu[{BjcW:2aX6tS2xTWkGVTFegZZMhe3Wkc4TyZZRmKGmwIIDy[ZNmdmOnIH;mJHto[W2vYT2zN3BeSVSSLDDJR|UxKD1iMD6wNFEh|ryPLh?= NIfZd2Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkGwNVU3PCd-Mk[xNFE2PjR:L3G+
HCT116 NEjxZXRHfW6ldHnvckBie3OjeR?= NFz1WZhKdmirYnn0bY9vKG:oIHH1do9z[SCtaX7hd4UhSSCjdYTvdIhwe3Cqb4L5cIF1cW:wIHH0JHQzQDhiaX6gbJVu[W5iSFPUNVE3KGOnbHzzJIJ6KGmvbYXuc4ZtfW:{ZYPj[Y5k\SCjbnHsfZNqeyxiSVO1NEA:KDBwMEC3JO69VS5? NW\TRZJURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xNFE2PjRpPkK2NVAyPTZ2PD;hQi=>
HCT116 NFXyNFJEgXSxdH;4bYNqfHliYYPzZZk> NX;OV5U{S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEOWMUG2JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEBxem:uaX\ldoF1cW:wIHL5JGJz\FViaX7jc5Jxd3KjdHnvckBie3OjeTygS2k2OCB;IECuNFMh|ryPLh?= M{nwTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MUCxOVY1Lz5{NkGwNVU3PDxxYU6=
HCT116 MoTPSpVv[3Srb36gZZN{[Xl? MlHJTY5pcWKrdHnvckBw\iCjdYLvdoEhc2mwYYPlJGIhcW5iaIXtZY4hUEOWMUG2JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiaHnzeI9v\SCKMzDwbI9{eGixconsZZRqd25iYomgbY1ufW6xZnz1c5Jme2OnbnPlJIFv[Wy7c3nzMEBKSzVyIE2gNU42KM7:TT6= M{D2clxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MUCxOVY1Lz5{NkGwNVU3PDxxYU6=
BL21 (DE3) Rosetta NFS1UmxHfW6ldHnvckBie3OjeR?= M1LXdVMxKG2rboO= NWjzb4N3UW6qaXLpeIlwdiCxZjDIbZMufGGpZ3XkJIh2dWGwIFH1do9z[SCDIHvpcoF{\SBqMUKyJJRwKDRyIILld4llfWW|KTDlfJBz\XO|ZXSgbY4hTXOlaHXybYNpcWFiY3;sbUBDVDJzIDjESVMqKFKxc3X0eIEh[2WubIOgeZNqdmdiYnnveIlvgWyjdHXkJHNVUzJic4Xid5Rz[XSnIHnuZ5Vj[XSnZDDmc5IhOzBibXnud{BjgSCKVGLGJIF{e2G7LDDJR|UxKD1iMD6wNFAxPCEQvF2u NXXEVFhZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkezPVEyOzNpPkK3N|kyOTN|PD;hQi=>
HeLa Kyoto NF3tTZhHfW6ldHnvckBie3OjeR?= NUG3cnFyOjBiaILz M{nVO2lvcGmkaYTpc44hd2ZiQYXyc5JiKEJia3nuZZNmKGmwIHj1cYFvKEinTHGgT5lwfG9iY3XscJMh[XO|ZYPz[YQh[XNiZX\m[YN1KG:wIHTpd5RzcWK3dHnvckBw\iCyaIPwbI8ucGm|dH;u[UBJOyC|ZYKxNEBt\X[nbDDpcoN2[mG2ZXSg[o9zKDJyIHjyd{whUUN3MDC9JFAvODBzNTFOwG0v M1LseFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5M{mxNVM{Lz5{N{O5NVE{OzxxYU6=
HeLa Kyoto Moi5SpVv[3Srb36gZZN{[Xl? NFPHZ|UzOCCqcoO= MmHJTY5pcWKrdHnvckBw\iCDdYLvdoEhSSCtaX7hd4Uh[XW2b4Doc5NxcG:{eXzheIlwdiCjdDDUbJIzQDhiaX6gbJVu[W5iSHXMZUBMgW:2bzDj[YxteyCrbnP1ZoF1\WRiZn;yJFIxKGi{czygTWM2OCB;IECuNFA3PyEQvF2u NW\veWZZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkezPVEyOzNpPkK3N|kyOTN|PD;hQi=>
multiple myeloma NFOxN29HfW6ldHnvckBie3OjeR?= NX3xTpgzW3WycILld5Nqd25ib3[gZ4VtdCCvaYTvd4l{KGmwIHj1cYFvKG23bITpdIxmKG27ZXzvcYEh[2WubIOsJGlEPTBiPTCwMlAxOyEQvF2u M3vXSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUG4NFk3Lz5{OEmxPFA6PjxxYU6=
Calu6 NVHTOohLSW62aYT1cY9zKGG|c3H5 M4nTWlIxKG2pL3vn M4qybVIyKGSjeYO= NXu2eJhpSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gR4FtfTZiY3XscJMhgGWwb3fyZYZ1\WRiaX6gcY92e2ViYYPz[ZN{\WRiYYOgeJVud3JiZ4Lve5RpKGmwaHnibZRqd25iYYSgNlAhdWdxa3esJJBwKGKrZDDh[I1qdmm|dHXy[YQh\m:{IEKxJIRigXN? NYjoVJR3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xNFE2PjRpPkK2NVAyPTZ2PD;hQi=>
HeLa Kyoto M{j6dmZ2dmO2aX;uJIF{e2G7 M{LqcVAvOjVidV2= MYSyNEBpenN? NYL4N3oxUW6qaXLpeIlwdiCxZjDBeZJwemFiQTDrbY5ie2VibH;jZYxqgmG2aX;uJIF1KHOyaX7kcIUhdWmlcn;0eYJ2dGW|IHnuJIh2dWGwIFjlUIEhU3mxdH:gZ4VtdHNiYYSgNE4zPSC3TTDpcoN2[mG2ZXSg[o9zKDJyIHjydy=> NGjubm89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{O5NVE{Oyd-MkezPVEyOzN:L3G+
MDA-MB-231 NEXaeIxHfW6ldHnvckBie3OjeR?= Mn;3NUB2VQ>? NYXrclVwPDhiaILz NH2wflJKdmS3Y4Tpc44hd2ZiY3jyc41we2:vZTDhcIlodm2nboSg[IVn\WO2czDpckBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHH0JFEhfU1iYX\0[ZIhPDhiaILzJIJ6KESDUFmgd5RicW6rbnegZoF{\WRiaX3teY5w\my3b4Lld4NmdmOnIHHzd4F6 M4PiNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7M{W4NVQ4Lz5{OUO1PFE1PzxxYU6=
MDA-MB-231 NF7yfWFHfW6ldHnvckBie3OjeR?= M4[yfFEhfU1? NILtOZo1QCCqcoO= NE\j[YhKdmS3Y4Tpc44hd2ZiYXLldpJidnRic4DpcoRt\SCob4LtZZRqd25id3n0bEB1emmyb3zhdkBidmRidHX0doFxd2yjcjDvZ4N2enKnbnPlJIlvKGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZZQhOSC3TTDh[pRmeiB2ODDodpMh[nliRFHQTUB{fGGrbnnu[{Bj[XOnZDDpcY12dm:obIXvdoV{[2WwY3WgZZN{[Xl? NVPFZplURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmzOVgyPDdpPkK5N|U5OTR5PD;hQi=>
MDA-MB-231 NXnvXHVqTnWwY4Tpc44h[XO|YYm= MXOwMlUhfU1? MlTsOFghcHK| NWT0b4ZEUW6qaXLpeIlwdiCxZjDhcJBp[S22dXL1cIlvKGmwIHj1cYFvKE2GQT3NRk0zOzFiY3XscJMh[XO|ZYPz[YQh[XNiYXLvcIl{cG2nboSgc4YhemWpdXzhdkBtd2OjdHnvckBw\iCycn;0[YlvKGG2IECuOUB2VSCjZoTldkA1QCCqcoOgZpkhTEGSSTDzeIFqdmmwZzDiZZNm\CCrbX31co9ndHWxcnXzZ4Vv[2ViYYPzZZk> MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTN3OEG0O{c,Ojl|NUixOFc9N2F-
MDA-MB-231 NIfQc5FHfW6ldHnvckBie3OjeR?= NU\KPXYxOC53IIXN M{f1ZlQ5KGi{cx?= MULJcohq[mm2aX;uJI9nKEGXUlvBJIlvKGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZZN{\XO|ZXSgZZMh[WKxbHnzbI1mdnRib3[gdoVofWyjcjDsc4NifGmxbjDv[kBxem:2ZXnuJIF1KDBwNTD1UUBi\nSncjC0PEBpenNiYomgSGFRUSC|dHHpcolv\yCkYYPl[EBqdW23bn;mcJVwemW|Y3XuZ4Uh[XO|YYm= NULnbYJQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmzOVgyPDdpPkK5N|U5OTR5PD;hQi=>
TC32 M1jrRZFJXFNiYYPzZZk> NILP[XRyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiVFOzNkBk\Wyucx?= NYfyRmtwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
Saos-2 NVzKTlFFeUiWUzDhd5NigQ>? NV\Fc2pMeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IGPhc5MuOiClZXzsdy=> M1[xPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SK-N-SH M4nYZZFJXFNiYYPzZZk> M4rBWpFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCVSz3OMXNJKGOnbHzz NYq2NnFLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
MG 63 (6-TG R) MWjxTHRUKGG|c3H5 NYPNcZl3eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IF3HJFY{KCh4LWTHJHIqKGOnbHzz M1Hvd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
NB1643 MUXxTHRUKGG|c3H5 MV;xTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhVkJzNkSzJINmdGy| M1rPVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
NB-EBc1 MX3xTHRUKGG|c3H5 MmPFdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgUmIuTUKlMTDj[Yxtew>? MoHpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
MG 63 (6-TG R) MXnxTHRUKGG|c3H5 MlrXdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgUWchPjNiKE[tWGchWiliY3XscJM> NU\i[|RRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
U-2 OS MlO5dWhVWyCjc4PhfS=> Mki5dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgWU0zKE:VIHPlcIx{ MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
SJ-GBM2 Mnj1dWhVWyCjc4PhfS=> NImyVnNyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiU1qtS2JOOiClZXzsdy=> Mk[2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
SK-N-MC NXfLV5ZJeUiWUzDhd5NigQ>? MVPxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhW0tvTj3NR{Bk\Wyucx?= NFOyOoo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
NB-EBc1 M4[zZ5FJXFNiYYPzZZk> MlLNdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKE6ELVXCZ|Eh[2WubIO= NXjIZm45RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
LAN-5 MVvxTHRUKGG|c3H5 MV\xTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhVEGQLUWgZ4VtdHN? MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
Rh18 NYPUdmtZeUiWUzDhd5NigQ>? MmDMdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKFKqMUigZ4VtdHN? NGDXPFQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
SK-N-MC NF7PNppyUFSVIHHzd4F6 M1z5dpFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJHNMNU5vTVOgZ4VtdHN? M3nlWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
TC32 MkDmdWhVWyCjc4PhfS=> M3rsSpFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJHREOzJiY3XscJM> Mm\tQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
Saos-2 NYX1[IJteUiWUzDhd5NigQ>? NEKzOlNyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBU[W:|LUKgZ4VtdHN? NUPWOZZSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-AURKA(T288) / p-EIF4E(S209) / c-Myc; 

PubMed: 28073841     


Inhibition of AURKA with alisertib downregulated p-EIF4E (S209) and c-MYC protein levels as assayed by Western blotting.

phospho-Aurora A / Aurora B; 

PubMed: 22863010     


MLN8237differentially inhibited phosphorylation of Aurora kinases. CMK cells were incubated with 0.1 µM paclitaxel for 18 hr, then DMSO or MLN8237 was added and incubated for 2 hr. The degree of phosphorylation of the Aurora kinases in each sample was determined by Western blot.

H3S10P / H3K27me2 / H3K27me3 / H3K9me2 / H3AcK / H4K16Ac; 

PubMed: 29477140     


THP-1 cells were treated with alisertib or DMSO for 48 h. The levels of histone modifications were detected by western blot analysis with the indicated antibodies. H3 was used as a loading control.

28073841 22863010 29477140
Growth inhibition assay
Cell viability; 

PubMed: 25632225     


PANC-1 and BxPC-3 cells were treated with ALS at concentrations ranging from 0.1 μM to 50 μM for 24 hours. The viability of PANC-1 and BxPC-3 cells determined by MTT assay. ALS, alisertib.

25632225
Immunofluorescence
acetylated α-tubulin / γ-tubulin; 

PubMed: 29401581     


Representative immunofluorescence (IF) image and graph in human PKD1-mutant WT9-7, WT9-12 cells or hTERT-RPE1 (RPE1) cells after 2 hours treatment with vehicle, ganetespib , or alisertib to inhibit AURKA, or combination of alisertib and ganetespib. acetylated α-tubulin (red); γ-tubulin (green); DAPI (blue). Scale bars, 5 μm.

E-cadherin / β-catenin / vimentin / p-SMAD5; 

PubMed: 23334326     


Immunofluorescence analysis of CD24 (-/low) cells treated with1 μM MLN8237 for 48 and 72 h showing reversion of EMT. E-cadherin and p-SMAD5 were labeled in red, β-catenin and vimentin were labeled in green, and DNA was labeled in blue with Hoechst dye.

Centrin-2 / tubulin; 

PubMed: 30899434     


Following inhibition of Aurora A kinase activity with 100 nM alisertib, cells with two or excess centrosomes similarly exhibit disorganized mitotic spindles. Cells with extra centrosomes are efficiently clustered into bipolar spindles prior to anaphase onset while those with supernumerary centrosomes undergo multipolar mitoses. Centrin-2, a marker of centrioles is shown in green, tubulin in red, and chromatin in blue. AurA inhibitor: alisertib.

phospho-Aurora A(T288); 

PubMed: 20382844     


MM1.S cells were treated with DMSO or MLN8237 (0.5μM) for 24 hours and then stained with anti-phospho (Thr288)-Aurora-A kinase antibody (red), αtubulin (green), and DNA (blue). Overlapping localization is shown in the merged images. Arrow indicates Aurora-A autophosphorylation on Thr288 in the centrosome (original magnification ×40). Magnified single mitotic cell image is shown in the right panel. 

29401581 23334326 30899434 20382844
体内研究 MLN8237口服处理,显著降低肿瘤负担,按15 mg/kg 和30 mg/kg剂量处理肿瘤生长抑制率(TGI) 分别为42%和80%,且与对照组相比,延迟小鼠寿命。[2] MLN8237 (30 mg/kg) 与Cisplatin (2 mg/kg) 联用作用于FLO-1移植瘤,与单独用药相比,抗癌活性增强,伴随着Ki-67表达受抑制,细胞核p73蛋白和cleaved caspase 3表达增强。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[1]
- 合并

Aurora A放射性闪光板酶实验:

进行Aurora A放射性闪光板酶实验,测定体外MLN8237抑制程度。在Sf9细胞中表达重组Aurora A,然后使用GST亲和层析进行纯化。Aurora A 肽底物与生物素联合形成生物素-GLRRASLG。在50 mM Hepes (pH 7.5), 10 mM MgCl2, 5 mM DTT, 0.05% Tween-20, 2 μM 肽底物, 3.3 μCi/mL [γ-33 P]ATP 2 μM, 和浓度不断增高的MLN8237 的混合物中进行Aurora A激酶 (5 nM)实验。
细胞实验:[2]
- 合并
  • Cell lines: MM1.S, MM.1R, LR5, RPMI 8226, DOX40, OPM1, OPM2, INA6, 和U266
  • Concentrations: 溶于DMSO,终浓度为~10 μM
  • Incubation Time: 24, 48, 和72小时
  • Method: 使用不同浓度MLN8237处理细胞24, 48,和72小时。通过MTT实验测定细胞活力,通过测定 3[3H]-胸甘渗透而测定细胞增殖。为了分析细胞周期,使用70%乙醇在-20oC下使细胞通透,然后与50 μg/mL PI 和20 单位/mL RNase-A温育。 通过流式细胞仪使用 BDFACS-Canto II和FlowJo软件分析DNA含量。 为了测定凋亡和衰老,使用异硫氰酸荧光素-annexin V和PI对细胞进行染色。通过流式细胞仪使用 BDFACS-Canto II和FlowJo软件测定凋亡细胞。
    (Only for Reference)
动物实验:[2]
- 合并
  • Animal Models: 皮下接种 MM1.S 细胞的SCID鼠
  • Dosages: ~30 mg/kg/day
  • Administration: 口服处理
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 27 mg/mL (52.03 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5%DMSO+30% PEG300+5%Tween-80+ddH2O
6mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 518.92
化学式

C27H20ClFN4O4

CAS号 1028486-01-2
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04479306 Recruiting Drug: Alisertib|Drug: Osimertinib|Drug: Sapanisertib Recurrent Lung Non-Small Cell Carcinoma|Stage IIIB Lung Cancer AJCC v8|Stage IV Lung Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8 M.D. Anderson Cancer Center June 18 2020 Phase 1
NCT02812056 Withdrawn Drug: Alisertib|Drug: TAK-228 Malignant Neoplasms of Digestive Organs|Malignant Neoplasms of Female Genital Organs|Malignant Neoplasms of Lip Oral Cavity and Pharynx|Malignant Neoplasms of Male Genital Organs M.D. Anderson Cancer Center|Millennium Pharmaceuticals Inc. September 2016 Phase 1
NCT02719691 Completed Drug: Alisertib|Drug: MLN0128 Metastatic Breast Cancer|Solid Tumors University of Colorado Denver May 13 2016 Phase 1
NCT02367352 Terminated Drug: Alisertib|Drug: Paclitaxel Advanced Solid Tumors|Ovarian Cancer|Small Cell Lung Cancer Millennium Pharmaceuticals Inc.|Takeda March 19 2015 Phase 1

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    What is the suggested formulation of this compound for mouse injection(i.p.)?

  • 回答:

    It can be dissolved in 6% DMSO/50% PEG 300/5% Tween 80/ddH2O at 10 mg/ml as a clear solution.

Aurora Kinase Signaling Pathway Map

Aurora Kinase Inhibitors with Unique Features

相关Aurora Kinase产品

Tags: 购买Alisertib (MLN8237) | Alisertib (MLN8237)供应商 | 采购Alisertib (MLN8237) | Alisertib (MLN8237)价格 | Alisertib (MLN8237)生产 | 订购Alisertib (MLN8237) | Alisertib (MLN8237)代理商
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID