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Niraparib (MK-4827) tosylate

目录号：S7625 别名: Niraparib tosylate, MK 4827 tosylate, ZEJULA 中文名称：尼拉帕尼甲苯磺酸盐

仅限科研使用

Niraparib tosylate (MK-4827, ZEJULA) 是PARP1/PARP2的选择性抑制剂，IC50分别为3.8 nM和2.1 nM。Niraparib可增加PARP-DNA复合体的形成，并导致DNA损伤、凋亡和细胞死亡。

Niraparib (MK-4827) tosylate Chemical Structure

CAS: 1038915-73-9

规格	价格	库存
10mM (1mL in DMSO)	RMB 1449.63	现货
5mg	RMB 959.15	现货
25mg	RMB 3251.76	现货
100mg	RMB 8165.6	现货
大包装	有超大折扣

今日订购，明日送达全国免运费分装免费分装成小规格产品（单支最小为1mg）如1支10mg产品可分装为10支1mg产品全国免费电话：400-668-6834 \| Email：info@selleck.cn

客户使用Selleck生产的Niraparib (MK-4827) tosylate发表文献33篇：

产品安全说明书

PARP抑制剂选择性比较

生物活性

产品描述

靶点

PARP2 ^[3] (Cell-free assay)	PARP1 ^[3] (Cell-free assay)
2.1 nM	3.8 nM

体外研究

微摩尔级浓度的niraparib使来自于肺癌、乳腺癌以及前列腺癌的肿瘤细胞对放射线敏感（不依赖于它们的p53状态），而对来自于正常组织的细胞没有此作用。Niraparib同样还可以使肿瘤细胞对过氧化氢敏感、在DNA复制时，将过氧化氢诱导的单链断裂转变为双链断裂^[5]。

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

HeLa	M3PEeGZ2dmO2aX;uJIF{e2G7			M13tbWlvcGmkaYTpc44hd2ZiUFHSVEBqdiCqeXTyc4dmdiCyZYLvfIll\S2rbnT1Z4VlKGi3bXHuJGhmVGFiY3XscJMh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDEUmEu\GGvYXflMYlv\HWlZXSgVGFTgWyjdHnvckwhTUN3MDC9JFAvODB2IN88UU4>	NUjVeJpERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm4O\|M6QDFpPkG5PFc{QThzPD;hQi=>
MDA-MB-436	NWrEO\|BKSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MXm2JIRigXN?	MX;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQT3NRk01OzZiY3XscJMh\XiycnXzd4lv\yCEUlPBNUA2Ozl4IDugNWc,SSCvdYThcpQh[W[2ZYKgOkBl[Xm\|IHL5JINmdGxidHn0[ZIu[my3ZTDhd5NigSxiQ1O1NEA:KDBwMEG4JO69VS5?	M1nwOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OEezPVgyLz5zOUi3N\|k5OTxxYU6=
HeLa	NUnITY5ZSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MYW3JIRigXN?	MVLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IFLSR2EyKGSnZnnjbYVvfCCqdX3hckBJ\UyjIHPlcIx{KGGodHXyJFch\GG7czDifUBk\WyuIITpeIVzNWKudXWgZZN{[XluIFPDOVAhRSByLkCzN{DPxE1w	NVfO[GtpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm4O\|M6QDFpPkG5PFc{QThzPD;hQi=>
HeLa	NVTrWVJlTnWwY4Tpc44h[XO\|YYm=			M3v2[WlvcGmkaYTpc44hd2ZiUFHSVEBqdiCqeXTyc4dmdiCyZYLvfIll\S2rbnT1Z4VlKGi3bXHuJGhmVGFiY3XscJMh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDEUmEu\GGvYXflMYlv\HWlZXSgVGFTgWyjdHnvckwhTUN7MDC9JFAvODR3IN88UU4>	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTh5M{m4NUc,OTl6N{O5PFE9N2F-
Capan1	NXzJSmliSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NYnhdIs6OTNiZHH5dy=>	MV;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEOjcHHuNUBk\WyuczDlfJBz\XO\|aX7nJGJTS0F{IE[xO\|Rl\WyWIH31eIF1cW:wIHHu[EBtd3O\|IH;mJJdqdGRvdInw[UBidGynbHWgZYZ1\XJiMUOg[IF6eyCkeTDj[YxtKHSrdHXyMYJtfWViYYPzZZktKEOFNUCgQUAxNjB7IN88UU4>	M1f2SVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OEezPVgyLz5zOUi3N\|k5OTxxYU6=
HeLa	M1\D[WFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NYSzeI5NPyCmYYnz	Mmj1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCKZVzhJINmdGy\|IHX4dJJme3Orbnege4lt\CC2eYDlJGJTS0FzIHHmeIVzKDdiZHH5d{BjgSClZXzsJJRqfGW{LXLseYUh[XO\|YYmsJGNEPTBiPTCwMlg3KM7:TT6=	MkXtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl6N{O5PFEoRjF7OEezPVgyRC:jPh?=
MDA-MB-436	Mnf0RY51cXS3bX;yJIF{e2G7	NX[we\|N[PTBibXevb4c>	NIHvT5c{OyCmYYnz	NYSzeGw6SW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUSzOkBk\WyuczDlfJBz\XO\|aX7nJGJTS0FzIEWzPVYhMyBzR{7BJI12fGGwdDD4[Y5w\3KjZoTl[EBqdiCFREGgcY92e2ViYYPz[ZN{\WRiYYOgeJVud3JicnXndoV{e2mxbjDheEA2OCCvZz;r[{wheG9iYnnkJIZweiB\|MzDkZZl{	MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTh5M{m4NUc,OTl6N{O5PFE9N2F-
MDA-MB-436	M3niVmFvfGm2dX3vdkBie3OjeR?=	NYjiTm9ZOTByIH3nM4to	MlXYN\|Mh\GG7cx?=	MlTXRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTR\|NjDj[YxteyCneIDy[ZN{cW6pIFLSR2EyKDV\|OU[gL{AyTz6DIH31eIFvfCC6ZX7v[5Ji\nSnZDDpckBETDFibX;1d4Uh[XO\|ZYPz[YQh[XNidIXtc5IhemWpcnXzd4lwdiCjdDCxNFAhdWdxa3esJJBwKHGmIH\vdkA{OyCmYYnz	NIHJWm49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUi3N\|k5OSd-MUm4O\|M6QDF:L3G+
Jurkat	MUnGeY5kfGmxbjDhd5NigQ>?		NVLycI1PQTZiaILz	NWnkPHM{UW6qaXLpeIlwdiCxZjDQRXJROSCrbjDoeY1idiCMdYLrZZQh[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKG:oIHPlcIwhfmmjYnnsbZR6KGGodHXyJFk3KGi{czDifUBOXFNiYYPzZZkhcW5icILld4Vv[2Vib3[gNVAxKHWPIH;mJJRmdW:8b3zvcYll\SxiRVO1NEA:KDBwMjFOwG0v	M1HFTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OEWwNVk6Lz5{M{i1NFE6QTxxYU6=
Jurkat	M3PJNmZ2dmO2aX;uJIF{e2G7		M2fFTlk3KGi{cx?=	NYO1c\|g3UW6qaXLpeIlwdiCxZjDQRXJROSCrbjDoeY1idiCMdYLrZZQh[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKG:oIHPlcIwhfmmjYnnsbZR6KGGodHXyJFk3KGi{czDifUBOXFNiYYPzZZktKEWFNUCgQUA{OSEQvF2u	MnfqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6NUCxPVkoRjJ\|OEWwNVk6RC:jPh?=
CAPAN-1	NFvwOWxHfW6ldHnvckBie3OjeR?=			NF7DNIZKdmirYnn0bY9vKG:oIGDBVnAhcW5iQmLDRVIu\GWoaXPp[Y51KGi3bXHuJGNCWEGQLUGgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCqeXTyc4dmdiCyZYLvfIll\S2rbnT1Z4VlKFCDUonsZZRqd25iYomgZ4VtdC2kYYPl[EBie3OjeTygTWM2OCB;IECuNFA{PSEQvF2u	NWTJZVFQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3OlExQTZpPkK1O\|YyODl4PD;hQi=>
HeLa	MX3GeY5kfGmxbjDhd5NigQ>?			MUfJcohq[mm2aX;uJI9nKFCDUmCgbY4hcHWvYX6gTIVN[SClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJIh6\HKxZ3XuJJBmem:6aXTlMYlv\HWlZXSgVGFTgWyjdHnvckBjgSClZXzsMYJie2WmIHHzd4F6NCCHQ{WwJF0hOC5yMESg{txONg>?	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd4MUC5Okc,OjV5NkGwPVY9N2F-
A2780	NHXseotHfW6ldHnvckBie3OjeR?=			NWPsV5JuUW6qaXLpeIlwdiCxZjDQRXJRKGmwIHj1cYFvKEF{N{iwJINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiaInkdo9o\W5icHXyc5hq\GVvaX7keYNm\CCSQWL5cIF1cW:wIHL5JINmdGxvYnHz[YQh[XO\|YYmsJGlEPTBiPTCwMlAxPCEQvF2u	NV:4WpdLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3OlExQTZpPkK1O\|YyODl4PD;hQi=>
A549	NFW5SXVEgXSxdH;4bYNqfHliYYPzZZk>		MnzKOUB1dyB5IHThfZM>	MXrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJJRz[W6\|ZnXjeIVlKHerdHigRnJESTJic3jSUmEh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuIIDyc4xq\mW{YYTpc44h[W[2ZYKgOUB1dyB5IHThfZMh[nliQ3XscHRqfGW{LVLseYUh[XO\|YYmsJGNEPTBiPTCwMlAyOSEQvF2u	Mle4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5NkGwPVYoRjJ3N{[xNFk3RC:jPh?=
MDA-MB-436	M4DJb2N6fG:2b4jpZ4l1gSCjc4PhfS=>			MnvTR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUSzOkBk\WyuczDjZZJzgWmwZzDCVmNCOSCvdYThcpQh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuIIDyc4xq\mW{YYTpc44tKEOFNUCgQUAxNjBzODFOwG0v	NV;pVGpLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3OlExQTZpPkK1O\|YyODl4PD;hQi=>
SUM1315MO2	NIK2XZdEgXSxdH;4bYNqfHliYYPzZZk>		MYOxNkBl[Xm\|	NV32OIhjS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW1WPMUOxOW1QOiClZXzsd{Bk[XK{eXnu[{BDWkODMTDteZRidnRiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJJBzd2yrZnXyZZRqd25iYX\0[ZIhOTJiZHH5d{BjgSCFZXzsWIl1\XJvQnz1[UBie3OjeTygR2M2OCB;IECuNFIh\|ryPLh?=	NFW2b\|k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe2NVA6Pid-MkW3OlExQTZ:L3G+
DoTc2-4510	MknIR5l1d3SxeHnjbZR6KGG\|c3H5		M3;wVFUhfG9iNzDkZZl{	M3i5SmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGRwXGN{LUS1NVAh[2WubIOgZ4FzenmrbnegRnJESTJibYX0ZY51KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4Yh[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFUhfG9iNzDkZZl{KGK7IFPlcIxVcXSncj3CcJVmKGG\|c3H5MEBESzVyIE2gNE4xOjNizszNMi=>	NXXqSYN3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3OlExQTZpPkK1O\|YyODl4PD;hQi=>
SUM149PT	M3HzRmN6fG:2b4jpZ4l1gSCjc4PhfS=>		NVLYXHRbPSC2bzC3JIRigXN?	NX;tTWdsS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW1WPMUS5VHQh[2WubIOgZ4FzenmrbnegRnJESTFibYX0ZY51KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4Yh[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFUhfG9iNzDkZZl{KGK7IFPlcIxVcXSncj3CcJVmKGG\|c3H5MEBESzVyIE2gNE4xOjRizszNMi=>	MnTpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5NkGwPVYoRjJ3N{[xNFk3RC:jPh?=
HeLa	MXnDfZRwfG:6aXPpeJkh[XO\|YYm=		MVW1JJRwKDdiZHH5dy=>	MUXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJJRz[W6\|ZnXjeIVlKHerdHigRnJESTFic3jSUmEh[XO\|ZYPz[YQh[XNicnXkeYN1cW:wIH;mJINmdGxidnnhZoltcXS7IHHmeIVzKDVidH:gO{Bl[Xm\|IHL5JGNmdGyWaYTldk1DdHWnIHHzd4F6NCCFQ{WwJF0hOC5yM{Sg{txONg>?	MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd4MUC5Okc,OjV5NkGwPVY9N2F-
HeLa	NX7LOWhRTnWwY4Tpc44h[XO\|YYm=			M3u1O2lvcGmkaYTpc44hd2ZiUFHSVEBqdiCqdX3hckBJ\UyjIHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4YhcHmmcn;n[Y4heGW{b4jp[IUucW6mdXPl[EBRSVK7bHH0bY9vKGK7IHPlcIwu[mG\|ZXSgZZN{[XluIFnDPVAhRSByLkC0OkDPxE1w	Mle1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5NkGwPVYoRjJ3N{[xNFk3RC:jPh?=
CAPAN-1	NGHzTpFHfW6ldHnvckBie3OjeR?=			MVPJcohq[mm2aX;uJI9nKFCDUmCgbY4hSlKFQUKt[IVncWOrZX70JIh2dWGwIFPBVGFPNTFiY3XscJMh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBpgWS{b3flckBx\XKxeHnk[U1qdmS3Y3XkJHBCWnmuYYTpc44h[nliY3XscE1j[XOnZDDhd5NigSxiSVO5NEA:KDBwMEWg{txONg>?	MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd4MUC5Okc,OjV5NkGwPVY9N2F-
A2780	M{DsSmZ2dmO2aX;uJIF{e2G7			NYrzTIt5UW6qaXLpeIlwdiCxZjDQRXJRKGmwIHj1cYFvKEF{N{iwJINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiaInkdo9o\W5icHXyc5hq\GVvaX7keYNm\CCSQWL5cIF1cW:wIHL5JINmdGxvYnHz[YQh[XO\|YYmsJGlEQTBiPTCwMlA2OiEQvF2u	NXjlOHV2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3OlExQTZpPkK1O\|YyODl4PD;hQi=>
UWB1.289	NG\XW5BEgXSxdH;4bYNqfHliYYPzZZk>		MnPpOUB1dyB5IHThfZM>	NXfQbmI6S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXVeEMT6yPFkh[2WubIOgZ4FzenmrbnegRnJESTFibYX0ZY51KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4Yh[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFUhfG9iNzDkZZl{KGK7IFPlcIxVcXSncj3CcJVmKGG\|c3H5MEBESzVyIE2gNE4xPTZizszNMi=>	NUHDUYFoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3OlExQTZpPkK1O\|YyODl4PD;hQi=>
Capan1	MXHDfZRwfG:6aXPpeJkh[XO\|YYm=			M{DPbGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KEKUQ1GyMYRm\mmlaXXueEBpfW2jbjDDZZBidjFiY3XscJMtKEOFNUCgQUAxNjB7IN88UU4>	NF\jcIY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe2NVA6Pid-MkW3OlExQTZ:L3G+
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BT-37	NUfOZ\|FyeUiWUzDhd5NigQ>?			MUjxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDCWE0{PyClZXzsdy=>	MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
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Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID

Western blot	c-PARP /c-caspase 3 / γ-H2AX	29158830
Immunofluorescence	Rad51 / Geminin	27614696

体内研究

MK-4827可以增强放射线对多种人类肿瘤异种移植的作用，无论是在p53野生型或是p53突变体。MK-4827在给药后1小时降低肿瘤中PAR水平并持续效果24小时^[1]。MK-4827体内给药能延长放射线处理后的动物寿命。MK-4827和放射治疗结合，显著提高肿瘤中裂解的caspase-3和γ-H2AX的水平^[4]。

细胞实验：^[2]	Cell lines: V-C8细胞 Concentrations: 50 nM Incubation Time: 24 h Method: 用PARP抑制剂MK-4827对中国仓鼠细胞V-C8（BRCA2-negative）进行处理，24小时后，洗涤并将细胞孵育在不含此化合物的培养基中5-7天，直到形成克隆。
动物实验：^[1]	Animal Models: 雌性裸鼠(Ncr Nu/Nu) Dosages: 25或50 mg/kg Administration: 口服

参考文献	[1] Wang L, et al. Invest New Drugs. 2012, 30(6):2113-20. [2] Patel AG, et al. J Biol Chem. 2012, 287(6):4198-210. [3] Jones P, et al. J Med Chem. 2009, 52(22):7170-85. [4] Mueller S, et al. Anticancer Res. 2013, 33(3):755-62. [5] Bridges KA, et al. oncotarget. 2014, 5(13):5076-86. + 展开

溶解度（25°C）

体外

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量	492.59
化学式	C₁₉H₂₀N₄O.C₇H₈O₃S
CAS号	1038915-73-9
储存条件	3年	-20°C	粉状
储存条件	2年	-80°C	溶于溶剂

Download Niraparib (MK-4827) tosylate SDF

动物体内配方计算器（澄清溶液）

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 μL 动物数量只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO + % + % Tween 80 + % ddH2O

%DMSO+ %

计算结果：

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于μL DMSO溶液（母液浓度mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取μL DMSO母液，加入μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入μL ddH₂O，混匀澄清。

体内配方配制方法：取μL DMSO母液，加入μL Corn oil，混匀澄清。

注意：1. 首先保证母液是澄清的；
2.一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×

稀释计算器分子量计算器

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