COVID-19相关产品

目录号 产品名 中文名称 产品描述 参考文献
S4430 Hydroxychloroquine Sulfate (NSC 4375) 羟氯喹 Hydroxychloroquine Sulfate (NSC 4375, HCQ)是一种抗疟疾药,用于治疗系统性红斑狼疮,类风湿关节炎等自身免疫病,炎症以及皮肤病。它也是autophagytoll-like receptor (TLR) 7/9的抑制剂。 Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial
S2853 Carfilzomib (PR-171) 卡非佐米 Carfilzomib (PR-171) 是一种不可逆proteasome抑制剂,在ANBL-6细胞中IC50为<5 nM,在体外优先抑制β5亚基的ChT-L活性,对PGPH和T-L活性很弱或没有作用。Carfilzomib 可激活自噬并诱导细胞凋亡。 Fast Identification of Possible Drug Treatment of Coronavirus Disease -19 (COVID-19) Through Computational Drug Repurposing Study
S7975 Favipiravir (T-705) 法匹拉韦 Favipiravir (T-705)是一种有效的选择性RNA-dependent RNA polymerase抑制剂,用于治疗流感病毒感染。 Discovering drugs to treat coronavirus disease 2019 (COVID-19)
S1835 Azithromycin (CP-62993) 阿奇霉素 Azithromycin (CP-62993, XZ-450)是一种抑制蛋白合成的抗生素,用于细菌感染的治疗。 Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial
S1620 Darunavir Ethanolate 地瑞那韦乙醇盐 Darunavir Ethanolate (TMC-114, UIC 94017)是一种人类免疫缺陷病毒(HIV)蛋白酶抑制剂。 Many drugs already approved by FDA may have promise against COVID-19
S4646 Ciclesonide 环索奈德 Ciclesonide (Alvesco, Omnaris, RPR251526, Zetonna)是一种糖皮质激素,用于治疗阻塞性气道疾病。 Therapeutic potential of ciclesonide inhalation for COVID-19 pneumonia: Report of three cases
S3035 Daunorubicin (RP 13057) HCl 道诺霉素,盐酸柔红霉素, 盐酸正丁霉素 Daunorubicin HCl (Daunomycin, RP 13057, Rubidomycin)抑制DNA和RNA合成,无细胞试验中抑制DNA合成的Ki为0.02 μM。Daunorubicin 是 topoisomerase II 的抑制剂并可诱导凋亡。 Many drugs already approved by FDA may have promise against COVID-19
S4157 Chloroquine diphosphate 二磷酸氯喹 Chloroquine diphosphate是一种4-氨基喹啉的抗疟疾和抗风湿药,也是一种ATM激活剂。Chloroquine 也是一种toll-like receptors (TLRs)的抑制剂。 Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
S2823 Tideglusib (NP031112) Tideglusib (NP031112, NP-12)是一种不可逆的,非ATP竞争性的GSK-3β抑制剂,无细胞试验中IC50为60 nM,不能抑制位于活性位点的同源于 Cys-199的 Cys激酶。Phase 2。 Structure of M pro From COVID-19 Virus and Discovery of Its Inhibitors
S2874 Camostat Mesilate 甲磺酸卡莫司他 Camostat (FOY-305, FOY-S980)是胰蛋白酶样的蛋白酶抑制剂,抑制上皮细胞钠离子通道(ENaC)功能,IC50为50 nM, 对Trypsin, Prostasin 和 Matriptase作用效果稍弱。 The Impact of Camostat Mesilate on COVID-19 Infection (CamoCO-19)
S8932 Remdesivir (GS-5734) 瑞德西韦,伦地西韦 Remdesivir (GS-5734)是腺苷类似物的单磷酰胺酸盐前药,是一种研究性的广谱抗病毒剂,对多种RNA病毒(包括埃博拉病毒和CoV病毒)具有体外活性。 Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
S5911 Bictegravir 比克替拉韦 Bictegravir (GS-9883)是一种新型的、有效的HIV-1 integrase抑制剂。 Potential COVID-2019 3C-like Protease Inhibitors Designed Using Generative Deep Learning Approaches
S1759 Pitavastatin (NK-104) calcium 匹伐他汀钙 Pitavastatin Calcium (NK-104, P-872441, itavastatin, nisvastatin),一种新型的Statins类药物,是pitavastatin的钙盐形式。Pitavastatin是高效的HMG-CoA reductase抑制剂。Pitavastatin Calcium 可通过抑制 ROS 的生成而减弱AGEs诱导的线粒体自噬。Pitavastatin Calcium 可诱导自噬和凋亡。 Potential COVID-2019 3C-like Protease Inhibitors Designed Using Generative Deep Learning Approaches
S1680 Disulfiram (NSC 190940) 双硫仑 Disulfiram (NSC 190940, Tetraethylthiuram disulfide, TETD)是一个特异性的乙醛脱氢酶 aldehyde-dehydrogenase (ALDH) 抑制剂,对hALDH1和hALDH2的IC50值分别0.15 μM和1.45 μM。Disulfiram 可用于治疗慢性酒精中毒,对酒精产生急性敏感性。Disulfiram 可诱导凋亡。Disulfiram 还是一种通过 gasdermin D (GSDMD) 作用的孔隙形成抑制剂。 Structure of M pro From COVID-19 Virus and Discovery of Its Inhibitors
S1386 Nafamostat mesilate (FUT-175) 甲磺酸萘莫司他 Nafamostat mesilate (FUT-175) 是合成的丝氨酸蛋白酶抑制剂,在血液透析中被用作是一种抗凝血剂。Nafamostat Mesylate可抑制SARS-CoV-2的激活,并用于COVID-19的治疗选择的研究中。Nafamostat Mesylate 可减弱炎症和凋亡。 Nafamostat inhibits SARS-CoV-2 infection, preventing COVID-19 transmission
S1706 Lamivudine (BCH-189) 拉米夫定, 拉美呋定, 拉米呋啶 Lamivudine (BCH-189, GR109714X)是一种有效的核苷类似物逆转录酶抑制剂,用于治疗慢性乙肝和艾滋病。它主要是通过阻滞HIV逆转录酶乙肝病毒聚合酶发挥其作用。 COVID-19 Registered Trials – and analysis
S8279 Shikonin (C.I. 75535) 紫草素 Shikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844)是一种 Pyruvate kinase M2 (PKM2) 有效的、特异的抑制剂。它是紫草的主要成分,紫草是一种中草药,具有多种生物活性。在细胞荧光淬灭试验中,Shikonin也是TMEM16A氯离子通道的抑制剂。Shikonin 通过抑制 tumor necrosis factor-α (TNF-α) 发挥抗炎作用,并可通过抑制 proteasome 来阻止 nuclear factor-κB (NF-κB) 信号途径的激活。
S1380 Lopinavir (ABT-378) 洛匹那韦 Lopinavir (ABT-378) 是一种有效的HIV protease抑制剂,无细胞试验中Ki为1.3 pM。 Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicin
S2485 Mitoxantrone (NSC-301739) 2HCl 米托蒽醌 Mitoxantrone 2HCl (NSC-301739) 是Mitoxantrone的盐酸盐形式。Mitoxantrone 是一种 type II topoisomeraseprotein kinase C (PKC)的抑制剂,对于PKC的IC50值为 8.5 μM。Mitoxantrone 可抑制MCF-7/wt cells的细胞增殖,对应的IC50值为0.42 μM。Mitoxantrone 还可诱导细胞凋亡。 Many drugs already approved by FDA may have promise against COVID-19
S4282 Nelfinavir (AG 1343) Mesylate 奈非那韦   Potential COVID-2019 3C-like Protease Inhibitors Designed Using Generative Deep Learning Approaches
S1185 Ritonavir (ABT-538) 利托那韦   Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicin
S1351 Ivermectin (MK-933) 伊维菌素, 依维菌素 Ivermectin (MK-933, IVM) 是一种chloride channel激活剂,用作广谱抗寄生虫药。Ivermectin (MK-933, IVM) 是 P2X4α7 nicotinic acetylcholine receptors (nAChRs) 的特异性正变构效应物。Ivermectin 对 HIV-1 和登革热dengue virus均具有有效的抗病毒活性。Ivermectin 可通过AKT/mTOR信号通路来诱导自噬,并诱导线粒体自噬。 Parasite Drug Shows Early Promise Against COVID-19 in Vitro
S1401 Tenofovir 替诺福韦, 泰诺福韦 Tenofovir (GS-1278) 对reverse transcriptase(逆转录酶)和B型肝炎病毒感染具有抑制作用。 COVID-19 Registered Trials – and analysis
S5250 Darunavir 达芦那韦   Many drugs already approved by FDA may have promise against COVID-19
S7579 Ledipasvir (GS5885) 雷迪帕韦 Ledipasvir (GS5885) 是一种HCV NS5A polymerase抑制剂,用于治疗丙型肝炎病毒感染。 Prediction of the SARS-CoV-2 (2019-nCoV) 3C-like protease (3CL pro) structure: virtual screening reveals velpatasvir, ledipasvir, and other drug repur
S1538 Telaprevir (VX-950) 特拉匹韦 Telaprevir (VX-950, LY-570310, MP-424)是一种丙型肝炎病毒(HCV)NS3-4A丝氨酸蛋白酶抑制剂,IC50为0.354 μM。 α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment
S1183 Danoprevir (ITMN-191) 丹诺瑞韦 Danoprevir (ITMN-191, RG7227) 是一种肽类抑制剂,作用于丙型肝炎病毒(HCV)的NS3/4A蛋白酶IC50为0.2-3.5 nM,抑制HCV 1A/1B/4/5/6基因型比抑制2B/3A基因型效果高10倍左右。Phase 2。 First Clinical Study Using HCV Protease Inhibitor Danoprevir to Treat Naive and Experienced COVID-19 Patients
S2169 Rosuvastatin (ZD4522) calcium 瑞舒伐他汀钙 Rosuvastatin Calcium (ZD4522)是一种竞争性HMG-CoA reductase抑制剂,无细胞试验中IC50为11 nM。 Many drugs already approved by FDA may have promise against COVID-19
S1289 Carmofur 卡莫氟 Carmofur (HCFU) 是嘧啶类似物,是一种作抗肿瘤药。 Structure of M pro From COVID-19 Virus and Discovery of Its Inhibitors
S7947 PX-12 PX-12 (DB05448, 1-methyl propyl 2-imidazolyl disulfide)是一种有效的 thioredoxin-1 (Trx-1) 抑制剂,作用于 Trx-1 上 Cys73 的不可逆硫代烷基化。Phase 2。 Structure of M pro From COVID-19 Virus and Discovery of Its Inhibitors
S3079 Atovaquone 阿托喹酮 Atovaquone (Atavaquone)用于治疗或预防肺孢子菌肺炎,弓形虫病, 疟疾和巴贝西虫。 Many drugs already approved by FDA may have promise against COVID-19
S2926 TDZD-8 TDZD-8 (NP 01139) 是一种非ATP竞争性GSK-3β抑制剂,IC50为2 μM;对CDK1, casein kinase II, PKA和PKC具有最低限度的抑制效果。 Structure of M pro From COVID-19 Virus and Discovery of Its Inhibitors
S1691 Praziquantel 吡喹酮 Praziquantel是一种驱虫药,有效作用于扁形虫。 Potential COVID-2019 3C-like Protease Inhibitors Designed Using Generative Deep Learning Approaches
S3733 Boceprevir 博赛泼维 Boceprevir (EBP 520, SCH 503034)是一种口服的、直接作用于hepatitis C virus (HCV) protease的抑制剂,对NS3蛋白酶的Ki值为14 nM。在治疗慢性肝炎C(genotype 1)中,常与其他抗病毒共同给药。 α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment
S3724 Velpatasvir 维帕他韦   Prediction of the SARS-CoV-2 (2019-nCoV) 3C-like protease (3CL pro) structure: virtual screening reveals velpatasvir, ledipasvir, and other drug repur
S2071 Prulifloxacin (NM441) 普鲁利沙星 Prulifloxacin (NM441, AF 3013)是ulifloxacin的前体药物,是一种广谱喹诺酮类抗菌药。 Potential COVID-2019 3C-like Protease Inhibitors Designed Using Generative Deep Learning Approaches
S9567 Indinavir Sulfate 硫酸茚地那韦 Indinavir sulfate (Crixivan, L-735524, MK-639)是一种有效的、特异的HIV-1 protease抑制剂,广泛用于艾滋病的治疗。 Potential Therapeutic Agents for COVID-19 Based on the Analysis of Protease and RNA Polymerase Docking
S2079 Moexipril HCl 莫西普利 Moexipril HCl (RS-10085)是一种口服有效的非巯基血管紧张素转化酶(ACE)抑制剂,IC50为0.041 µM,用于治疗高血压和充血性心脏衰竭。 Many drugs already approved by FDA may have promise against COVID-19
S3037 Bepotastine Besilate 苯磺贝他斯汀 Bepotastine Besilate (TAU 284)是一种非镇静作用的,选择性的组胺1 (H1)受体拮抗剂,pIC50为5.7。 Many drugs already approved by FDA may have promise against COVID-19
S5940 Bepotastine 贝他斯汀 Bepotastine是一种非镇静的、选择性histamine 1 (H1) receptor拮抗剂。 Many drugs already approved by FDA may have promise against COVID-19
S6676 Ebselen 依布硒 Ebselen (DR 3305, SPI-1005, PZ-51, CCG-39161)是HIV-1复制的小分子衣壳抑制剂,在TR-FRET分析中的IC50为46.1 nM。 Structure of M pro From COVID-19 Virus and Discovery of Its Inhibitors
S8969 Molnupiravir (EIDD-2801) Molnupiravir (EIDD-2801, MK-4482) 是一种口服生物活性的核糖核苷类似物β-d-N4-hydroxycytidine (NHC; EIDD-1931)的前药,具有广谱的抗病毒活性 antiviral activity 对抗 SARS-CoV-2MERS-CoVSARS-CoVCOVID-19的病原体。 An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice
目录号 产品名 中文名称 产品描述 参考文献
A2012 Tocilizumab (anti-IL-6R) Tocilizumab treatment in COVID‐19: A single center experience
A2011 Sarilumab (anti-IL-6Rα) After disappointing early numbers, Sanofi and Regeneron scale back Kevzara's COVID-19 test
目录号 产品名 中文名称 产品描述 参考文献
L7000 Antiviral Compound Library 抗病毒化合物库 700种抗病毒化合物的独特集合,用于探索新型抗病毒药物。
L7200 Nucleoside Analogue Library 核苷类似物库 195种核苷类似物的独特集合,适用于高通量筛选(HTS)和高内涵筛选(HCS)。