COVID-19相关抑制剂
目录号 产品名 中文名称 产品描述 参考文献
S4430 Hydroxychloroquine Sulfate 羟氯喹 Hydroxychloroquine Sulfate (HCQ) 是一种抗疟疾药,用于治疗系统性红斑狼疮,类风湿关节炎等自身免疫病,炎症以及皮肤病。它也是autophagytoll-like receptor (TLR) 7/9的抑制剂。 Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial
S2853 Carfilzomib (PR-171) 卡非佐米 Carfilzomib (PR-171) 是一种不可逆proteasome抑制剂,在ANBL-6细胞中IC50为<5 nM,在体外优先抑制β5亚基的ChT-L活性,对PGPH和T-L活性很弱或没有作用。Carfilzomib 可激活自噬并诱导细胞凋亡。 Fast Identification of Possible Drug Treatment of Coronavirus Disease -19 (COVID-19) Through Computational Drug Repurposing Study
S7975 Favipiravir (T-705) 法匹拉韦 Favipiravir (T-705)是一种有效的选择性RNA-dependent RNA polymerase抑制剂,用于治疗流感病毒感染。 Discovering drugs to treat coronavirus disease 2019 (COVID-19)
S1835 Azithromycin 阿奇霉素 Azithromycin是一种抑制蛋白合成的抗生素,用于细菌感染的治疗。 Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial
S1620 Darunavir Ethanolate 地瑞那韦 Darunavir Ethanolate (TMC-114, UIC 94017)是一种人类免疫缺陷病毒(HIV)蛋白酶抑制剂。 Many drugs already approved by FDA may have promise against COVID-19
S4646 Ciclesonide 环索奈德 Ciclesonide是一种糖皮质激素,用于治疗阻塞性气道疾病。 Therapeutic potential of ciclesonide inhalation for COVID-19 pneumonia: Report of three cases
S3035 Daunorubicin HCl 道诺霉素 Daunorubicin HCl抑制DNA和RNA合成,无细胞试验中抑制DNA合成的Ki为0.02 μM。Daunorubicin 是 topoisomerase II 的抑制剂并可诱导凋亡。 Many drugs already approved by FDA may have promise against COVID-19
S4157 Chloroquine diphosphate 二磷酸氯喹 Chloroquine diphosphate是一种4-氨基喹啉的抗疟疾和抗风湿药,也是一种ATM激活剂。Chloroquine 也是一种toll-like receptors (TLRs)的抑制剂。 Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
S2823 Tideglusib Tideglusib是一种不可逆的,非ATP竞争性的GSK-3β抑制剂,无细胞试验中IC50为60 nM,不能抑制位于活性位点的同源于 Cys-199的 Cys激酶。Phase 2。 Structure of M pro From COVID-19 Virus and Discovery of Its Inhibitors
S2874 Camostat Mesilate 甲磺酸卡莫司他 Camostat Mesilate是胰蛋白酶样的蛋白酶抑制剂,抑制上皮细胞钠离子通道(ENaC)功能,IC50为50 nM, 对Trypsin, Prostasin 和 Matriptase作用效果稍弱。 The Impact of Camostat Mesilate on COVID-19 Infection (CamoCO-19)
S8932 Remdesivir (GS-5734) 瑞德西韦,伦地西韦 Remdesivir是腺苷类似物的单磷酰胺酸盐前药,是一种研究性的广谱抗病毒剂,对多种RNA病毒(包括埃博拉病毒和CoV病毒)具有体外活性。 Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
S5911 Bictegravir 比克替拉韦 Bictegravir是一种新型的、有效的HIV-1 integrase抑制剂。 Potential COVID-2019 3C-like Protease Inhibitors Designed Using Generative Deep Learning Approaches
S1759 Pitavastatin Calcium 匹伐他汀钙 Pitavastatin Calcium (NK-104, P-872441, itavastatin, nisvastatin),一种新型的Statins类药物,是pitavastatin的钙盐形式。Pitavastatin是高效的HMG-CoA reductase抑制剂。Pitavastatin Calcium 可通过抑制 ROS 的生成而减弱AGEs诱导的线粒体自噬。Pitavastatin Calcium 可诱导自噬和凋亡。 Potential COVID-2019 3C-like Protease Inhibitors Designed Using Generative Deep Learning Approaches
S1680 Disulfiram 双硫仑 Disulfiram (NSC 190940) 是一个特异性的乙醛脱氢酶 aldehyde-dehydrogenase (ALDH) 抑制剂,对hALDH1和hALDH2的IC50值分别0.15 μM和1.45 μM。Disulfiram 可用于治疗慢性酒精中毒,对酒精产生急性敏感性。Disulfiram 可诱导凋亡。 Structure of M pro From COVID-19 Virus and Discovery of Its Inhibitors
S1386 Nafamostat Mesylate 甲磺酸萘莫司他 Nafamostat mesilate (FUT-175) 是合成的丝氨酸蛋白酶抑制剂,在血液透析中被用作是一种抗凝血剂。Nafamostat Mesylate可抑制SARS-CoV-2的激活,并用于COVID-19的治疗选择的研究中。Nafamostat Mesylate 可减弱炎症和凋亡。 Nafamostat inhibits SARS-CoV-2 infection, preventing COVID-19 transmission
S1706 Lamivudine 拉米夫定, 拉美呋定, 拉米呋啶 Lamivudine (GR109714X)是一种有效的核苷类似物逆转录酶抑制剂,用于治疗慢性乙肝和艾滋病。它主要是通过阻滞HIV逆转录酶乙肝病毒聚合酶发挥其作用。 COVID-19 Registered Trials – and analysis
S8279 Shikonin 紫草素 Shikonin,是一种 Pyruvate kinase M2 (PKM2) 有效的、特异的抑制剂。它是紫草的主要成分,紫草是一种中草药,具有多种生物活性。在细胞荧光淬灭试验中,Shikonin也是TMEM16A氯离子通道的抑制剂。Shikonin 通过抑制 tumor necrosis factor-α (TNF-α) 发挥抗炎作用,并可通过抑制 proteasome 来阻止 nuclear factor-κB (NF-κB) 信号途径的激活。
S1380 Lopinavir 洛匹那韦 Lopinavir (ABT-378) 是一种有效的HIV protease抑制剂,无细胞试验中Ki为1.3 pM。 Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicin
S2485 Mitoxantrone 2HCl 米托蒽醌 Mitoxantrone 2HCl (NSC-301739) 是Mitoxantrone的盐酸盐形式。Mitoxantrone 是一种 type II topoisomeraseprotein kinase C (PKC)的抑制剂,对于PKC的IC50值为 8.5 μM。Mitoxantrone 可抑制MCF-7/wt cells的细胞增殖,对应的IC50值为0.42 μM。Mitoxantrone 还可诱导细胞凋亡。 Many drugs already approved by FDA may have promise against COVID-19
S4282 Nelfinavir Mesylate 奈非那韦 Nelfinavir Mesylate (Viracept, AG1343) 是强效的HIV protease抑制剂,Ki为2 nM。 Potential COVID-2019 3C-like Protease Inhibitors Designed Using Generative Deep Learning Approaches
S1185 Ritonavir 利托那韦 Ritonavir (ABT-538, A 84538) 是Cytochrome P450 3AHIV蛋白酶抑制剂,用于治疗HIV感染和AIDS。抑制Cytochrome P450 2D6, P-Glycoprotein,诱导Cytochrome P450 2C19, Cytochrome P450 1A2, Cytochrome P450 2C9, Cytochrome P450 2B6UDP Glucuronosyltransferases。Ritonavir 可诱导凋亡。 Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicin
S1351 Ivermectin 伊维菌素, 依维菌素 Ivermectin (MK-933, IVM) 是一种chloride channel激活剂,用作广谱抗寄生虫药。Ivermectin (MK-933, IVM) 是 P2X4α7 nicotinic acetylcholine receptors (nAChRs) 的特异性正变构效应物。Ivermectin 对 HIV-1 和登革热dengue virus均具有有效的抗病毒活性。Ivermectin 可通过AKT/mTOR信号通路来诱导自噬,并诱导线粒体自噬。 Parasite Drug Shows Early Promise Against COVID-19 in Vitro
S1401 Tenofovir 替诺福韦, 泰诺福韦 Tenofovir (GS-1278) 对reverse transcriptase(逆转录酶)和B型肝炎病毒感染具有抑制作用。 COVID-19 Registered Trials – and analysis
S5250 Darunavir 达芦那韦 Darunavir (TMC114) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection. Many drugs already approved by FDA may have promise against COVID-19
S7579 Ledipasvir (GS5885) 雷迪帕韦 Ledipasvir (GS5885) 是一种HCV NS5A polymerase抑制剂,用于治疗丙型肝炎病毒感染。 Prediction of the SARS-CoV-2 (2019-nCoV) 3C-like protease (3CL pro) structure: virtual screening reveals velpatasvir, ledipasvir, and other drug repur
S1538 Telaprevir (VX-950) 特拉匹韦 Telaprevir (VX-950, LY-570310, MP-424)是一种丙型肝炎病毒(HCV)NS3-4A丝氨酸蛋白酶抑制剂,IC50为0.354 μM。 α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment
S1183 Danoprevir (ITMN-191) 丹诺瑞韦 Danoprevir (ITMN-191, RG7227) 是一种肽类抑制剂,作用于丙型肝炎病毒(HCV)的NS3/4A蛋白酶IC50为0.2-3.5 nM,抑制HCV 1A/1B/4/5/6基因型比抑制2B/3A基因型效果高10倍左右。Phase 2。 First Clinical Study Using HCV Protease Inhibitor Danoprevir to Treat Naive and Experienced COVID-19 Patients
S2169 Rosuvastatin Calcium 瑞舒伐他汀钙 Rosuvastatin Calcium (ZD4522)是一种竞争性HMG-CoA reductase抑制剂,无细胞试验中IC50为11 nM。 Many drugs already approved by FDA may have promise against COVID-19
S1289 Carmofur 卡莫氟 Carmofur (HCFU) 是嘧啶类似物,是一种作抗肿瘤药。 Structure of M pro From COVID-19 Virus and Discovery of Its Inhibitors
S7947 PX-12 PX-12是一种有效的 thioredoxin-1 (Trx-1) 抑制剂,作用于 Trx-1 上 Cys73 的不可逆硫代烷基化。Phase 2。 Structure of M pro From COVID-19 Virus and Discovery of Its Inhibitors
S3079 Atovaquone 阿托喹酮 Atovaquone 用于治疗或预防肺孢子菌肺炎,弓形虫病, 疟疾和巴贝西虫。 Many drugs already approved by FDA may have promise against COVID-19
S2926 TDZD-8 TDZD-8 (NP 01139) 是一种非ATP竞争性GSK-3β抑制剂,IC50为2 μM;对CDK1, casein kinase II, PKA和PKC具有最低限度的抑制效果。 Structure of M pro From COVID-19 Virus and Discovery of Its Inhibitors
S1691 Praziquantel 吡喹酮 Praziquantel是一种驱虫药,有效作用于扁形虫。 Potential COVID-2019 3C-like Protease Inhibitors Designed Using Generative Deep Learning Approaches
S3733 Boceprevir 博赛泼维 Boceprevir是一种口服的、直接作用于hepatitis C virus (HCV) protease的抑制剂,对NS3蛋白酶的Ki值为14 nM。在治疗慢性肝炎C(genotype 1)中,常与其他抗病毒共同给药。 α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment
S3724 Velpatasvir 维帕他韦 Velpatasvir (GS-5816) 是二代NS5A抑制剂,抑制丙型肝炎病毒(HCV)的复制。 Prediction of the SARS-CoV-2 (2019-nCoV) 3C-like protease (3CL pro) structure: virtual screening reveals velpatasvir, ledipasvir, and other drug repur
S2071 Prulifloxacin (NM441) 普鲁利沙星 Prulifloxacin是ulifloxacin的前体药物,是一种广谱喹诺酮类抗菌药。 Potential COVID-2019 3C-like Protease Inhibitors Designed Using Generative Deep Learning Approaches
S9567 Indinavir Sulfate 硫酸茚地那韦 Indinavir sulfate是一种有效的、特异的HIV-1 protease抑制剂,广泛用于艾滋病的治疗。 Potential Therapeutic Agents for COVID-19 Based on the Analysis of Protease and RNA Polymerase Docking
S2079 Moexipril HCl 莫西普利 Moexipril HCl是一种口服有效的非巯基血管紧张素转化酶(ACE)抑制剂,IC50为0.041 µM,用于治疗高血压和充血性心脏衰竭。 Many drugs already approved by FDA may have promise against COVID-19
S3037 Bepotastine Besilate 苯磺贝他斯汀 Bepotastine Besilate是一种非镇静作用的,选择性的组胺1 (H1)受体拮抗剂,pIC50为5.7。 Many drugs already approved by FDA may have promise against COVID-19
S5940 Bepotastine 贝他斯汀 Bepotastine是一种非镇静的、选择性histamine 1 (H1) receptor拮抗剂。 Many drugs already approved by FDA may have promise against COVID-19
S6676 Ebselen 依布硒 Ebselen是HIV-1复制的小分子衣壳抑制剂,在TR-FRET分析中的IC50为46.1 nM。 Structure of M pro From COVID-19 Virus and Discovery of Its Inhibitors
S8969 EIDD-2801 EIDD-2801 是一种口服生物活性的核糖核苷类似物β-d-N4-hydroxycytidine (NHC; EIDD-1931)的前药,具有广谱的抗病毒活性 antiviral activity 对抗 SARS-CoV-2MERS-CoVSARS-CoVCOVID-19的病原体。 An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice
COVID-19相关抗体
目录号 产品名 中文名称 产品描述 参考文献
A2012 Tocilizumab (anti-IL-6R) 托珠单抗 (anti-IL-6R) Tocilizumab (anti-human IL-6R)是人源单克隆单体,可与interleukin-6 receptor结合发挥抑制作用。MW: 148 KD。 Tocilizumab treatment in COVID‐19: A single center experience
A2011 Sarilumab (anti-IL-6Rα) Sarilumab (anti-IL-6Rα)是人源anti-IL-6Rα单克隆抗体,与膜结合的和可溶性的IL-6Rα以高亲和力结合。MW: 144.13 KD。 After disappointing early numbers, Sanofi and Regeneron scale back Kevzara's COVID-19 test
COVID-19相关化合物库
目录号 产品名 中文名称 产品描述
L7000 Antiviral Compound Library
L7200 Nucleoside Analogue Library