Tanespimycin (17-AAG)

目录号:S1141 别名: CP127374,NSC-330507, KOS 953

Tanespimycin (17-AAG) Chemical Structure

Molecular Weight(MW): 585.69

Tanespimycin (17-AAG)是一种有效的HSP90抑制剂,无细胞试验中IC50为5 nM,作用于来自肿瘤细胞的HSP90比作用于来自正常细胞HSP90结合亲和力高100倍。Phase 2。

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RMB 1597.01 现货
RMB 1221.85 现货
RMB 3016.43 现货
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客户使用该产品的9个实验数据:

  • (A) Cell lines were seeded in 96-well plates and treated with 10 nM of 17-AAG for 72 h. Cell survival was analyzed using CellTiter-Glo. Both parental H3122 cells (red bar) and H3122 CR cells (blue bar) show sensitivity to 17-AAG. (B) Suppression of ALK signaling by 17-AAG in resistant H3122 CR cells. H3122 parental and resistant cells were exposed to increasing concentrations of 17-AAG for 6 h.

    PNAS, 2011, 108: 7535-40. Tanespimycin (17-AAG) purchased from Selleck.

    (A) Treatment of DIPG cells with an HSP90 inhibitor, 17-AAG, resulted in decreased invasion toward SVZ hNPC CM at high doses. (B) Cell viability of DIPG cells treated with increasing doses of 17-AAG, by the CellTiter-Glo assay.

    Cell, 2017, 170(5):845-859.e19. Tanespimycin (17-AAG) purchased from Selleck.

  • SKBR3 cells were treated with FW-04-806 at 10, 20, 40 uM for 24 h; 17AAG was used as a positive control at 1 and 2 uM. Hsp70, Hsp90, and Cdc37 protein level were analyzed with western blotting using relevant antibodies.

    Mol Cancer 2014 13, 150. Tanespimycin (17-AAG) purchased from Selleck.

    Western blot analysis of immunoprecipitated Hsp90/BIP complexes in MOLT-4 (T-ALL) and RS4;11 (B-ALL) treated for 22 h with CX-4945 (5 μM) and bortezomib (2.5 nM) either alone or in combination. 500 μg of protein lysates were immunoprecipitated with anti-Hsp90 antibody. Relative Induction values (Rel.Ind.) were obtained by normalizing to Hsp90 bands density. 17-AAG: tanespimycin.

    Oncotarget, 2015, 51: S659-S660. Tanespimycin (17-AAG) purchased from Selleck.

  • Co-IP analyses of direct interaction between HSP90 and HIF-1α in 17-AAG (5 μM)-treated HSCs using antibodies against HSP90, HIF-1α or IgG (n = 2).

    Br J Pharmacol, 2017, 174(5):409-423. Tanespimycin (17-AAG) purchased from Selleck.

    Treatment with an Hsp90 inhibitor results in a dose-dependent decrease in complex IV activity. A, because Hsp90 levels were reduced by 80%, in PINK1 null dopaminergic neuronal cells, the effects of specific inhibition of Hsp90 using 17-AAG were analyzed in wild-type neuronal cells. Both complex IV activity and Hsp60 levels were decreased significantly in 17-AAG-treated cells in a dose-dependent manner. B, in contrast, 17-AAG treatment did not affect expression of Hsp90 and LRPPRC.

    J Biol Chem 2012 287, 44109-20. Tanespimycin (17-AAG) purchased from Selleck.

  • UPR modulators destabilize mSmoM2. NIH 3T3 cells expressing mSmoM2 protein were treated with HSP90 inhibitors 17-AAG (50 uM and 100 uM) and SNX-2112 (25 uM and 50 uM) and the proteasome inhibitor bortezomib (25 uM and 50 uM) for 4 h prior to lysis. DMSO was the vehicle control. Western blotting of whole-cell lysates revealed mSmoM2 protein to be destabilized in response to HSP-90 inhibitors but not in response to bortezomib. Tubulin was the loading control. CHOP results indicate ER stress.

    Mol Cell Biol 2013 33(12), 2375-87. Tanespimycin (17-AAG) purchased from Selleck.

    Hsp90 is up-regulated during aging. Whole-cell extracts were prepared from young (PD 20) and old (PD 40) HFSN1 cells. c HFSN1 cells (PD 40) were treated with different concentration of the Hsp90 inhibitor (17-AAG) and then re-incubated for 24 h. Whole-cell extracts were prepared and analyzed by western blot using the indicated antibodies.

    Age 2013 35, 549-62. Tanespimycin (17-AAG) purchased from Selleck.

  • Four types of the colon cancer cells with indicated K-Ras phenotype were incubated with indicated concentration of 17-AAG for 24 h, which were then analyzed for protein expression by WB.

    Oncotarget 2014 5, 4269-82. Tanespimycin (17-AAG) purchased from Selleck.

产品安全说明书

HSP (e.g. HSP90)抑制剂选择性比较

生物活性

产品描述 Tanespimycin (17-AAG)是一种有效的HSP90抑制剂,无细胞试验中IC50为5 nM,作用于来自肿瘤细胞的HSP90比作用于来自正常细胞HSP90结合亲和力高100倍。Phase 2。
特性 17-AAG对正常细胞的毒性很小。
靶点
HSP90 [1]
(Cell-free assay)
5 nM
体外研究

17-AAG是格尔德霉素类似物, 但是与过量表达HER-2的癌细胞 (BT474, N87, SKOV3 和SKBR3)或BT474乳腺细胞衍生的Hsp90亲和力高100多倍,IC50为5-6 nM, 而作用于正常人类原代细胞时,IC50为400-943 nM, 因为肿瘤Hsp90 处于多伴复合体状态,具有高ATP酶活性,而正常细胞Hsp90 处于潜在未结合状态, 且直接与那些细胞中17-AAG毒性相关。[1]17-AAG 引起HER2, HER3, Akt,突变和野生型雄激素受体(AR)降解,导致前列腺细胞如LNCaP, LAPC-4, DU-145,和PC-3中RB依赖的 G1 期生长停顿,IC50为25-45 nM。[2]除了诱导改变野生型BCR-ABL的Ba/F3细胞凋亡, IC50为5.2 μM, 17-AAG还通过诱导野生型和突变型 BCR-ABL蛋白降解,而诱导改变抗 Imatinib Mesylate的 T315I和 E255K BCR-ABL突变型细胞生长,IC50分别为2.3 μM 和 1.0 μM。[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A549 MniyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTjTWM2OD1yLkCwNFMxOyEQvF2= MX7TRW5ITVJ?
IST-MEL1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknQTWM2OD1yLkCwNFQxPyEQvF2= NVTpVYhWW0GQR1XS
NCI-SNU-1 M{WxTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTBwMECyNFch|ryP NHm2dlVUSU6JRWK=
FADU NV7kZmo6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojVTWM2OD1yLkCwNlA6KM7:TR?= NYLIUZVXW0GQR1XS
C32 NHn3Um1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTBwMECzNFQh|ryP M3f5eXNCVkeHUh?=
D-566MG MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTBwMECzPUDPxE1? M1rMNXNCVkeHUh?=
LXF-289 NXLaeJdMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHH2SVFKSzVyPUCuNFA1OTlizszN MlPVV2FPT0WU
HGC-27 NHX6UZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTBwMEC1NUDPxE1? MVvTRW5ITVJ?
RPMI-7951 MmPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfOTWM2OD1yLkCwO|E4KM7:TR?= MmnDV2FPT0WU
HSC-3 MljES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vxPWlEPTB;MD6wNFkzQSEQvF2= MVfTRW5ITVJ?
MIA-PaCa-2 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITsTplKSzVyPUCuNFExODlizszN NUS2Rox{W0GQR1XS
KS-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDzOI9ZUUN3ME2wMlAyOzV3IN88US=> MoHQV2FPT0WU
CAL-51 Mm\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnhc3RKSzVyPUCuNFE1ODVizszN MUPTRW5ITVJ?
MDA-MB-361 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHyNIZOUUN3ME2wMlAyPDl3IN88US=> M1LoWXNCVkeHUh?=
TI-73 NHfM[FdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWSxUVh3UUN3ME2wMlAyPzl4IN88US=> NXHoOJZ3W0GQR1XS
AGS NILiOJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvYTWM2OD1yLkCxPVM5KM7:TR?= NGmwdZlUSU6JRWK=
NCI-H460 NX3PSYJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTBwMEG5O|Qh|ryP MUDTRW5ITVJ?
A204 NXrZUo45T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVy2N2xuUUN3ME2wMlAzOjR7IN88US=> MkLlV2FPT0WU
CHL-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfpTWM2OD1yLkCyNlUyKM7:TR?= MW\TRW5ITVJ?
DU-4475 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEX5fFNKSzVyPUCuNFIzPjFizszN MVTTRW5ITVJ?
CGTH-W-1 NWPDWpN2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDHWlFKSzVyPUCuNFI{PDlizszN MkjVV2FPT0WU
HCC2218 MknIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTtTWM2OD1yLkCyOFk1KM7:TR?= NYLMVoZzW0GQR1XS
A2780 NVHPb3BjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nyc2lEPTB;MD6wNlU{OSEQvF2= MknjV2FPT0WU
NCI-H720 NWHlPGlVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwMEK1OFYh|ryP M4DqUHNCVkeHUh?=
NCI-N87 M1jB[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXLTWM2OD1yLkCyOVk{KM7:TR?= MkHBV2FPT0WU
CHP-212 M2nMc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTBwMEK2Nlgh|ryP MXLTRW5ITVJ?
NCI-H23 M1vuOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX:5N4d{UUN3ME2wMlAzPjZ3IN88US=> NVvvSVZ1W0GQR1XS
D-263MG MljKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInmPFNKSzVyPUCuNFI4QDZizszN NG\rNIRUSU6JRWK=
ME-180 MlXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LpPGlEPTB;MD6wNlg6OSEQvF2= M{\tV3NCVkeHUh?=
SW982 NVrGeZJwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPLe|dkUUN3ME2wMlAzQTl7IN88US=> M3HoVnNCVkeHUh?=
OE19 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV30O3dSUUN3ME2wMlA{ODd5IN88US=> MVXTRW5ITVJ?
SK-LU-1 Ml7hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rBU2lEPTB;MD6wN|A5OiEQvF2= NWrrSoQ5W0GQR1XS
H4 MluxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;tb4RzUUN3ME2wMlA{ODlizszN MY\TRW5ITVJ?
HT-144 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnf3TWM2OD1yLkCzNFk{KM7:TR?= NXq0XnY2W0GQR1XS
SK-UT-1 M3fwZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMEOxO|gh|ryP NIXhbVBUSU6JRWK=
D-336MG M{C2bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfLVoxKSzVyPUCuNFM{ODlizszN NWLpUJdjW0GQR1XS
MDA-MB-175-VII NYnXZVM{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTBwMEOzOVQh|ryP M3jqUnNCVkeHUh?=
GAMG MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTBwMEO0N|Uh|ryP M{TJOnNCVkeHUh?=
CP50-MEL-B Mn7IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLnTWM2OD1yLkCzOFUh|ryP NV;rOXJtW0GQR1XS
OVCAR-5 NVf3SWxWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPmPFRKSzVyPUCuNFM1QCEQvF2= MYXTRW5ITVJ?
SK-MES-1 Mo\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfyOW9wUUN3ME2wMlA{PjB4IN88US=> MV;TRW5ITVJ?
VM-CUB-1 MnvKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonRTWM2OD1yLkCzOlU4KM7:TR?= NWfFcW52W0GQR1XS
WM-115 M2Dlc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLsO2NOUUN3ME2wMlA{PzZ{IN88US=> NW\6Rm9uW0GQR1XS
DSH1 NVnTZWtIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn[xTWM2OD1yLkCzPFA4KM7:TR?= NEHt[nNUSU6JRWK=
Becker MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;aZ5hKSzVyPUCuNFM5QDVizszN MVnTRW5ITVJ?
SW962 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjOTVdKSzVyPUCuNFM6PDVizszN MUTTRW5ITVJ?
TYK-nu MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHxPFFmUUN3ME2wMlA{QTh3IN88US=> NVfGU2xvW0GQR1XS
HO-1-N-1 NULEeW9UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXyUVh3UUN3ME2wMlA1ODJzIN88US=> MYrTRW5ITVJ?
T98G M{TwO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmm3TWM2OD1yLkC0NVA{KM7:TR?= NYXSXm1KW0GQR1XS
ACN NIDIboNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;FT3FGUUN3ME2wMlA1OTZ{IN88US=> NEH3V5BUSU6JRWK=
SW780 NYrle4MzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwMESyNFMh|ryP MoC2V2FPT0WU
Detroit562 NXT3U|dRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPQUWZKSzVyPUCuNFQzOzlizszN MVzTRW5ITVJ?
BB49-HNC NIrRfIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfKNmNKSzVyPUCuNFQzPDNizszN MV\TRW5ITVJ?
HN M4ry[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTBwMESyO|Ih|ryP NUWwSlZvW0GQR1XS
H9 NYq5NW04T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPCTWM2OD1yLkC0N|cyKM7:TR?= NVHMRpJPW0GQR1XS
VA-ES-BJ M{TENmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1H5Z2lEPTB;MD6wOFQ1PyEQvF2= M3LPS3NCVkeHUh?=
MEL-JUSO NFW2UmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrGd5JKSzVyPUCuNFQ1PzVizszN MWPTRW5ITVJ?
BT-474 Mm\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XPNGlEPTB;MD6wOFUh|ryP NEW4Zo5USU6JRWK=
CaR-1 NW\rVmtlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTBwMES1OFkh|ryP MX\TRW5ITVJ?
PSN1 M3\PT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwMES2NFMh|ryP M2\DUnNCVkeHUh?=
KYSE-510 M1nqPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTTTWM2OD1yLkC0OlQ6KM7:TR?= MkT6V2FPT0WU
KP-4 NEDtdVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPRRm82UUN3ME2wMlA1PzV|IN88US=> M{DLU3NCVkeHUh?=
KYSE-410 NH7RUplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkX4TWM2OD1yLkC0O|czKM7:TR?= Mn\NV2FPT0WU
G-402 NGnNVHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwMES3PFkh|ryP NV;sdZVNW0GQR1XS
DOK NWHaU5R4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVT3OYpNUUN3ME2wMlA1QTB{IN88US=> NF;nOFdUSU6JRWK=
COR-L88 NXiyTGwxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPETWM2OD1yLkC0PVEzKM7:TR?= MoS3V2FPT0WU
SKG-IIIa MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwMES5PFYh|ryP M36wXHNCVkeHUh?=
AN3-CA MnW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkC3TWM2OD1yLkC1JO69VQ>? MnrBV2FPT0WU
SW48 NE\QXm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfsXIVKSzVyPUCuNFUxOzlizszN MU\TRW5ITVJ?
YKG-1 M{\WNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjJTWM2OD1yLkC1NFcyKM7:TR?= NYe3U3MzW0GQR1XS
KYSE-150 MmfWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTjVHpKSzVyPUCuNFUzOzVizszN M2\JZXNCVkeHUh?=
HuO-3N1 M1H6XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1m0eGlEPTB;MD6wOVI{PyEQvF2= NF;tdJRUSU6JRWK=
LB1047-RCC MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwMEWyPVYh|ryP NFf4O5hUSU6JRWK=
NCI-H2030 MkT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkezTWM2OD1yLkC1OFE1KM7:TR?= NWTPTIc1W0GQR1XS
YH-13 NGjveo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkGxTWM2OD1yLkC1O|IzKM7:TR?= MojNV2FPT0WU
5637 NIHaeo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwMEW3OEDPxE1? M3HGbXNCVkeHUh?=
LOXIMVI NGDhV3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwMEW4O|Ih|ryP MWfTRW5ITVJ?
GT3TKB M1vPdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;1V2lKSzVyPUCuNFU6PDJizszN MVvTRW5ITVJ?
TCCSUP M{XhOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXXbpZCUUN3ME2wMlA2QTZ2IN88US=> NXXhSYFJW0GQR1XS
EPLC-272H NWWz[JdST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XDWGlEPTB;MD6wOlIxPSEQvF2= NX\aO5ZvW0GQR1XS
LU-99A MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTBwME[yN|ch|ryP MXrTRW5ITVJ?
NCI-H1755 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTBwME[zOFEh|ryP NFHGWXFUSU6JRWK=
KM12 Moq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHEe|RTUUN3ME2wMlA3OzR6IN88US=> NH\oPWtUSU6JRWK=
SF295 NXq0W41kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTBwME[0OVIh|ryP MoTIV2FPT0WU
MZ2-MEL NIDYR2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fZ[2lEPTB;MD6wOlU2OyEQvF2= MnPUV2FPT0WU
HEC-1 NUDtXVJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmKyTWM2OD1yLkC2OVg5KM7:TR?= NH\qUGFUSU6JRWK=
SW684 NFXxNVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHLTWM2OD1yLkC2OVkyKM7:TR?= Mk\OV2FPT0WU
SF539 MofES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXLXnFKSzVyPUCuNFY3QDFizszN M1zEcnNCVkeHUh?=
GMS-10 M2HF[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3Ic2JKSzVyPUCuNFY3QTlizszN NYKzZYhoW0GQR1XS
MV-4-11 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwME[4NFMh|ryP NEficoZUSU6JRWK=
HT-29 M3HlVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYflVHd2UUN3ME2wMlA3QTF7IN88US=> NES4fGtUSU6JRWK=
23132-87 NYn2dHdFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvjdZpOUUN3ME2wMlA3QTVizszN MX7TRW5ITVJ?
SW620 Ml\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWm1SZhnUUN3ME2wMlA4ODJ4IN88US=> M2XSVnNCVkeHUh?=
HCC1806 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTBwMEexN|Eh|ryP M1z0T3NCVkeHUh?=
Hs-578-T M2fyNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7IZVdKSzVyPUCuNFczODhizszN NYDMfoVVW0GQR1XS
A2058 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HFU2lEPTB;MD6wO|IzQCEQvF2= NYnrZ3gyW0GQR1XS
MEL-HO MlG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3H3SWlEPTB;MD6wO|I2PSEQvF2= M4DTfHNCVkeHUh?=
HCC2998 M1zVT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHXPVBKSzVyPUCuNFc{PDdizszN NEfTN4ZUSU6JRWK=
HuO9 M2\hbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3:2NmlEPTB;MD6wO|U5QSEQvF2= M4X6RnNCVkeHUh?=
CAL-39 M3vXUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIO3d4FKSzVyPUCuNFc4PjZizszN MmDBV2FPT0WU
M14 NWHyOIxUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTBwMEe5NVMh|ryP NV62W4JxW0GQR1XS
BFTC-909 Ml;PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrpfXA3UUN3ME2wMlA4QTZ7IN88US=> MoH5V2FPT0WU
TE-11 NEnEeXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LufmlEPTB;MD6wO|k6PiEQvF2= M3TVXnNCVkeHUh?=
TGBC1TKB MoPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmG4TWM2OD1yLkC4NFQ{KM7:TR?= M3\ic3NCVkeHUh?=
L-363 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDzN5JKSzVyPUCuNFgzODZizszN NI\1flNUSU6JRWK=
A431 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWq1SpE3UUN3ME2wMlA5OjFizszN NFrIV4xUSU6JRWK=
MKN45 M1vFOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrxTWM2OD1yLkC4NlE6KM7:TR?= MmLTV2FPT0WU
HT-1080 M{nIeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoW4TWM2OD1yLkC4OFM6KM7:TR?= NIHaWHJUSU6JRWK=
OVCAR-8 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHpXIpHUUN3ME2wMlA5PjJ{IN88US=> MlLSV2FPT0WU
LCLC-97TM1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFT3UodKSzVyPUCuNFg4OjhizszN M{ju[XNCVkeHUh?=
M059J MkLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTxWIVKSzVyPUCuNFkxOjdizszN M3y4R3NCVkeHUh?=
SK-MEL-2 M4LVSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHFeJdKSzVyPUCuNFkxPiEQvF2= Mo\qV2FPT0WU
TE-1 NX61TJpYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjMTWM2OD1yLkC5NlA1KM7:TR?= MlnzV2FPT0WU
KYSE-180 NGDp[GdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nqcmlEPTB;MD6wPVI3OiEQvF2= MkfrV2FPT0WU
D-247MG MoHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwMEm0OVUh|ryP M{PXR3NCVkeHUh?=
8-MG-BA MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2Po[mlEPTB;MD6wPVQ4OiEQvF2= NYDFV4NNW0GQR1XS
NCI-H1792 M2jjXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfTWHJVUUN3ME2wMlA6PjF6IN88US=> NV7pd4pQW0GQR1XS
MCF7 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfDTWM2OD1yLkC5Olc4KM7:TR?= NHnx[ZJUSU6JRWK=
NCI-H2122 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW[2OpJiUUN3ME2wMlA6PzR3IN88US=> NULaSHBqW0GQR1XS
EFO-27 NXrORpUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTBwMEm5PVch|ryP NGf5PYtUSU6JRWK=
LB2241-RCC NGT3WZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTBwMUCwOVQh|ryP NYrPbnFyW0GQR1XS
SN12C NIS4Ro5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnLTWM2OD1yLkGwNVA4KM7:TR?= NY[zT21xW0GQR1XS
A498 MlfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPzUYdPUUN3ME2wMlExOThizszN MoXZV2FPT0WU
PANC-03-27 M37QdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\3TI9mUUN3ME2wMlExOjh4IN88US=> MkjrV2FPT0WU
NCI-H1581 NVf4SYpbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PWPWlEPTB;MD6xNFI6KM7:TR?= MnXLV2FPT0WU
U-87-MG NUDjVmxDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPvVmhZUUN3ME2wMlExOzB5IN88US=> NX2yTFVZW0GQR1XS
G-401 NGDy[HlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzhTWM2OD1yLkGwN|U{KM7:TR?= MUDTRW5ITVJ?
SiHa M3vGSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\3TWM2OD1yLkGwOFg3KM7:TR?= Ml3EV2FPT0WU
U251 M13kN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3O4S2lEPTB;MD6xNFUzPSEQvF2= NH6zW4ZUSU6JRWK=
MMAC-SF MkPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTBwMUC1N|Eh|ryP NGX5ZVVUSU6JRWK=
BB65-RCC NYK5[5lQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnUXG1KSzVyPUCuNVA2PTRizszN MnTKV2FPT0WU
NKM-1 MlXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTxTWM2OD1yLkGwOlY3KM7:TR?= Mmr6V2FPT0WU
HD-MY-Z M4rD[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjjOG5KSzVyPUCuNVA5PzNizszN NYHHVmdTW0GQR1XS
TGBC11TKB NEHxbIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3OwXmlEPTB;MD6xNFkxOyEQvF2= MVLTRW5ITVJ?
COLO-679 NEKybXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTBwMUGyNVEh|ryP MkXsV2FPT0WU
TE-8 NV7uVZlvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTtTWM2OD1yLkGxNlY1KM7:TR?= MlrIV2FPT0WU
SK-MEL-28 MmfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDKUVRKSzVyPUCuNVE{OjFizszN NWiyPZNSW0GQR1XS
SH-4 M2nVR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoX0TWM2OD1yLkGxN|U3KM7:TR?= MYLTRW5ITVJ?
KALS-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zaNmlEPTB;MD6xNVM6OyEQvF2= NUnqN4o3W0GQR1XS
RKO MkXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7MTWM2OD1yLkGxO|Y1KM7:TR?= M1vTVHNCVkeHUh?=
OMC-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LkOmlEPTB;MD6xNVc6PyEQvF2= MVXTRW5ITVJ?
BT-549 MmXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTBwMUG3PVkh|ryP MnPvV2FPT0WU
NCI-H28 MkfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnqTWM2OD1yLkGxPFE4KM7:TR?= MUfTRW5ITVJ?
RXF393 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LwdWlEPTB;MD6xNVk5OiEQvF2= NX3T[HB6W0GQR1XS
COLO-829 NEn0eWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHxeVRKSzVyPUCuNVIxODVizszN M1;mbnNCVkeHUh?=
HMV-II NH3LR2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3T1XmlEPTB;MD6xNlAzKM7:TR?= NYOycY9DW0GQR1XS
SW1990 NF\HTWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2r2OmlEPTB;MD6xNlE2PyEQvF2= MlPSV2FPT0WU
NCI-H1437 MorXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\rTWM2OD1yLkGyNVU4KM7:TR?= NHrrZ3ZUSU6JRWK=
SNB75 NH7hUFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFX1WYVKSzVyPUCuNVIyPjlizszN NHHX[HJUSU6JRWK=
EW-3 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmj0TWM2OD1yLkGyOlYyKM7:TR?= MmDmV2FPT0WU
SAS NFf4c3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXRZZZPUUN3ME2wMlEzPjlizszN MXTTRW5ITVJ?
NCI-H1666 NYnEdlR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmOwTWM2OD1yLkGyO|c1KM7:TR?= M370TnNCVkeHUh?=
A375 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzyOWVUUUN3ME2wMlEzPzd6IN88US=> NFXneFZUSU6JRWK=
CAMA-1 NUiwcm9YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkn2TWM2OD1yLkGyPVI1KM7:TR?= NH:4dnBUSU6JRWK=
HuP-T4 M1e5PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjtR2JKSzVyPUCuNVI6PDNizszN MmXOV2FPT0WU
NCI-H292 M4HXemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF74ZW9KSzVyPUCuNVMyOSEQvF2= Mlv4V2FPT0WU
PC-14 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUC0SnViUUN3ME2wMlE{OjFzIN88US=> NXrWR4lzW0GQR1XS
BPH-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nU[mlEPTB;MD6xN|QyKM7:TR?= M3HlbnNCVkeHUh?=
GAK Ml\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwMUO1Olch|ryP MV;TRW5ITVJ?
VMRC-RCZ MkjmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHsOm9KSzVyPUCuNVM4PjJizszN NVjoeXBuW0GQR1XS
SK-MEL-24 NYnhOVB1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PQ[2lEPTB;MD6xN|g4KM7:TR?= NEnWWnJUSU6JRWK=
LB831-BLC NYHufotWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwMUO4PFMh|ryP NXi3Wmo3W0GQR1XS
NCI-H2452 MlrGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTBwMUO5OVYh|ryP M335b3NCVkeHUh?=
RT-112 MkTVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXmTWM2OD1yLkG0NFM2KM7:TR?= Mmn4V2FPT0WU
GP5d NGO0eJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwMUSxNFQh|ryP NWWwdWFWW0GQR1XS
LC-2-ad NUjMb2RxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTBwMUSxNlEh|ryP NH3WZ2hUSU6JRWK=
MPP-89 NXLDTGxQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXwTWM2OD1yLkG0NVI2KM7:TR?= M4TJcHNCVkeHUh?=
NUGC-3 Mm\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvGTWM2OD1yLkG0OFc5KM7:TR?= MYTTRW5ITVJ?
GI-1 NF\tXHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4C5VGlEPTB;MD6xOFU2QCEQvF2= Ml7oV2FPT0WU
HCC1419 NFzVSllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYKxV2dwUUN3ME2wMlE1PTd4IN88US=> NIfZZZZUSU6JRWK=
SW1573 MlzxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\qTWM2OD1yLkG0O|U5KM7:TR?= NFvJVmlUSU6JRWK=
NCI-H2347 NEjn[G5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWm5d|VbUUN3ME2wMlE1QDN7IN88US=> NWLWeItWW0GQR1XS
Mewo NW\QUXBiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTPTWM2OD1yLkG0PFg6KM7:TR?= NVLzTmNJW0GQR1XS
639-V NGjGS5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTJNI1YUUN3ME2wMlE2ODF|IN88US=> M33jNHNCVkeHUh?=
AsPC-1 NImzeI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37wTGlEPTB;MD6xOVIzPSEQvF2= MUfTRW5ITVJ?
NCI-H1648 MkfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHJWZk5UUN3ME2wMlE2OjN{IN88US=> NETqSWtUSU6JRWK=
786-0 M{XZOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILZeoZKSzVyPUCuNVU{QDFizszN NH\sUmtUSU6JRWK=
ETK-1 M1Pje2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\DeGZKSzVyPUCuNVU6KM7:TR?= Mk\oV2FPT0WU
BxPC-3 NIDxSGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjOTWM2OD1yLkG1PVY3KM7:TR?= MXTTRW5ITVJ?
CAL-62 NHfQcmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn:5TWM2OD1yLkG2NVY6KM7:TR?= MlHWV2FPT0WU
HCC1937 NWPje5gyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{f5ZmlEPTB;MD6xOlI4PSEQvF2= M3z5fXNCVkeHUh?=
NCI-H1299 MkHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLrTWM2OD1yLkG2Nlg2KM7:TR?= M3fReHNCVkeHUh?=
SW1088 Ml:zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPlbodKSzVyPUCuNVY1OTNizszN MV7TRW5ITVJ?
FTC-133 NV3lOnpDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;PW2lEPTB;MD6xOlU1KM7:TR?= M3fh[nNCVkeHUh?=
OC-314 NH\KSXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3S0R2lEPTB;MD6xOlY6KM7:TR?= NGHFcoNUSU6JRWK=
SCC-9 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4ryZmlEPTB;MD6xOlcyPiEQvF2= NX;oPJp{W0GQR1XS
HT-1376 MkjUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjZZ2ZNUUN3ME2wMlE3QTN4IN88US=> M13rd3NCVkeHUh?=
U-2-OS MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LZXmlEPTB;MD6xO|E4OyEQvF2= M4rKbXNCVkeHUh?=
COLO-824 NXLF[HpFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{Pzb2lEPTB;MD6xO|I6PCEQvF2= NIrlZVdUSU6JRWK=
BB30-HNC MknKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rFN2lEPTB;MD6xO|M{KM7:TR?= NU\TOGNKW0GQR1XS
NCI-H2087 NHG2TnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYKzTJpDUUN3ME2wMlE4OzZ6IN88US=> NV70RWF5W0GQR1XS
NCI-H2170 MnqyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vveWlEPTB;MD6xO|U{PiEQvF2= MXLTRW5ITVJ?
SK-OV-3 NFjEenFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPFfIdsUUN3ME2wMlE4PTdzIN88US=> NF[yWVBUSU6JRWK=
MZ7-mel M{HMW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTBwMUe2OFkh|ryP MomxV2FPT0WU
NCI-H650 M2\KRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwMUe2PFIh|ryP MYHTRW5ITVJ?
KOSC-2 MoPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7hTWM2OD1yLkG3O|M1KM7:TR?= NV:0cmV{W0GQR1XS
SCC-4 M4PjXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4n4VGlEPTB;MD6xO|c4PyEQvF2= M4rxfHNCVkeHUh?=
MDA-MB-157 MoXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHoTWM2OD1yLkG4NFgzKM7:TR?= NWDwZlg{W0GQR1XS
KYSE-520 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYmweFF[UUN3ME2wMlE5OiEQvF2= NYjtS|Z[W0GQR1XS
LK-2 M2j0UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwMUizNFMh|ryP NH3MU|JUSU6JRWK=
KNS-81-FD M3T3SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIS3UGFKSzVyPUCuNVg{QTRizszN NU\0T2x{W0GQR1XS
IGROV-1 M3;4NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LvTGlEPTB;MD6xPFQ1OyEQvF2= MorNV2FPT0WU
DEL NVTRblBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfvTWM2OD1yLkG4OFUh|ryP M1\BbXNCVkeHUh?=
NCI-H1395 M1;2fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2D4O2lEPTB;MD6xPFY5OiEQvF2= NFe1O|JUSU6JRWK=
JEG-3 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTBwMUi3NFUh|ryP M3XvbHNCVkeHUh?=
BCPAP M3XMOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH:xNXNKSzVyPUCuNVg5PzJizszN M1XNO3NCVkeHUh?=
CAL-27 MoXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\VVGlEPTB;MD6xPVAzOiEQvF2= M2fNb3NCVkeHUh?=
RD NIOxZZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwMUmxNVMh|ryP MmHoV2FPT0WU
RVH-421 M{DlRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPJSldKSzVyPUCuNVkyOTZizszN MYnTRW5ITVJ?
Capan-2 MlLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlqxTWM2OD1yLkG5NlU3KM7:TR?= MWnTRW5ITVJ?
COLO-680N M13qWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;BV|N6UUN3ME2wMlE6OzZ2IN88US=> MULTRW5ITVJ?
NCI-H1650 MkfIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFf5SopKSzVyPUCuNlAxPTdizszN MYPTRW5ITVJ?
SBC-5 Ml:4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fXNWlEPTB;MD6yNFEyQCEQvF2= M3XMenNCVkeHUh?=
U031 NV7CZmt[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEG1SlBKSzVyPUCuNlA2PDdizszN MmLvV2FPT0WU
S-117 MoLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vsTGlEPTB;MD6yNFU3PCEQvF2= M1fhPHNCVkeHUh?=
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AM-38 NG\JToxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTBwMkC4OFgh|ryP MoO5V2FPT0WU
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Ca9-22 NEXFN4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1ewPGlEPTB;ND60OVY6OSEQvF2= M{Dj[nNCVkeHUh?=
ES4 NF3lRoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHr4eIJKSzVyPUSuOFcxQTVizszN NIjvbmFUSU6JRWK=
ES6 NV7ib4xRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLwTWM2OD12LkS5OlU4KM7:TR?= MmWzV2FPT0WU
DMS-114 NH;ie5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTRwNUS2PVEh|ryP MY\TRW5ITVJ?
ONS-76 MmXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVK4XXdUUUN3ME20MlU4QTVizszN NWfweXZTW0GQR1XS
K-562 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLGVXdiUUN3ME20Mlc{QDF2IN88US=> NELEPIlUSU6JRWK=
MHH-NB-11 M4f5RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVm0VZJGUUN3ME20Mlc2PDZzIN88US=> M3XqVXNCVkeHUh?=
Calu-3 M1nu[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYqzb2Y2UUN3ME20Mlc5PTR6IN88US=> MXvTRW5ITVJ?
HT55 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTRwOES1OFUh|ryP NVnKVnFQW0GQR1XS
SK-N-FI NIfnUZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTRwOEWwNFkh|ryP M3;i[XNCVkeHUh?=
ES1 NFja[mNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjtdVlKSzVyPUSuPFYxPTdizszN MlHrV2FPT0WU
SF126 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3KxXmlEPTB;ND65N|E5PCEQvF2= M37aW3NCVkeHUh?=
ES5 NYj5c2h2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHjTWM2OD13LkGyOFI4KM7:TR?= M1m3WnNCVkeHUh?=
LoVo NYX6W5M5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHOTWM2OD13LkG1PFcyKM7:TR?= M2T2ZXNCVkeHUh?=
SNU-387 NY\QeG1ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHtPWhKSzVyPUWuN|I{OzlizszN NVXUSmRuW0GQR1XS
C8166 NIXpXIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4G5VGlEPTB;NT6zOlM{QSEQvF2= MlzlV2FPT0WU
LS-1034 NHfvRm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnoc5pKSzVyPUWuOFI{ODdizszN M1XvXnNCVkeHUh?=
GR-ST MlvrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DCdWlEPTB;NT61NlIxOSEQvF2= MYfTRW5ITVJ?
NCI-H1092 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;CcnY{UUN3ME21MlczQDR|IN88US=> MXfTRW5ITVJ?
647-V MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWOxdY8zUUN3ME21Mlc1PzB4IN88US=> M4XKe3NCVkeHUh?=
EW-13 M1j6VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTVwN{[2Nlch|ryP NXHNNYdZW0GQR1XS
KGN NFLOXHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTZwMEm5NlEh|ryP MXHTRW5ITVJ?
D-423MG MoK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTJTWM2OD14LkSwNlg1KM7:TR?= NX\sVnA6W0GQR1XS
ECC10 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTjTWM2OD15LkGwNVAyKM7:TR?= NU\y[nFMW0GQR1XS
TE-5 NXfuO3lGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4i1UWlEPTB;Nz60NVI6QCEQvF2= MUPTRW5ITVJ?
P12-ICHIKAWA MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\NTWM2OD15LkS1OVI{KM7:TR?= M4W3dnNCVkeHUh?=
NCI-H82 NWX5fmRET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvLcY5KSzVyPUeuOFU4ODFizszN NI\oVYRUSU6JRWK=
NCI-H1993 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1KyNGlEPTB;Nz64N|A3OyEQvF2= Mme2V2FPT0WU
RH-1 NVHBTGdiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\DVHdKSzVyPUeuPFUzPDRizszN MYTTRW5ITVJ?
SW948 Mn;4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETVSpZKSzVyPUeuPVYxPDlizszN MV7TRW5ITVJ?
CAL-33 Mn;jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7tTWM2OD15Lkm5PVM5KM7:TR?= NYXtem1sW0GQR1XS
U-266 NEfHfYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLDe3BKSzVyPUiuNVU4PzdizszN MmfwV2FPT0WU
CAL-72 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXrTWM2OD16LkKwN|Ih|ryP MUjTRW5ITVJ?
SNU-423 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnH6TWM2OD17LkO2OlY3KM7:TR?= MUjTRW5ITVJ?
KG-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTlwNUi0OVYh|ryP NFTPdGtUSU6JRWK=
HCC1395 NEC5RWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTlwOUKzOVIh|ryP Mm\GV2FPT0WU
BE-13 MlG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\5TWM2OD1zMD64PFkzKM7:TR?= M33CUnNCVkeHUh?=
MKN7 NVPDVWl6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXf1XmM6UUN3ME2xNE46PzZ3IN88US=> MV\TRW5ITVJ?
697 NH6xNmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTWOYJNUUN3ME2xNU4yPDd{IN88US=> MV;TRW5ITVJ?
LU-135 M4HodGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTFzLkKzNFch|ryP MVLTRW5ITVJ?
ES7 NXvwVoFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTFzLkOzNVMh|ryP NXy4ZZFKW0GQR1XS
SK-HEP-1 M1HiXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUm5NoVjUUN3ME2xNU44PjR4IN88US=> MY\TRW5ITVJ?
BEN MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrwSmJKSzVyPUGxMlg2OSEQvF2= NVHWXYx4W0GQR1XS
NCI-H1770 M4i3dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWe0NItCUUN3ME2xNk4yOjZizszN NHGxUoJUSU6JRWK=
SW13 NELWbGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;TNVQ{UUN3ME2xNk4yPTRzIN88US=> NHHMeZBUSU6JRWK=
MZ1-PC MmjaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1y2OGlEPTB;MUKuOVQ2OiEQvF2= NUi4UYl[W0GQR1XS
Mo-T NFyzOplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHPTWM2OD1zMj63OFIyKM7:TR?= MX7TRW5ITVJ?
HLE MnXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33TV2lEPTB;MUKuPFIyPSEQvF2= MYDTRW5ITVJ?
RCC10RGB Mn3LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHMR2FKSzVyPUGzMlY4OSEQvF2= MUnTRW5ITVJ?
COLO-320-HSR NHvwZVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorNTWM2OD1zMz63N|gyKM7:TR?= MYTTRW5ITVJ?
BHT-101 NGq4XXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTF|LkizOFUh|ryP MlHhV2FPT0WU
OCUB-M MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PSOGlEPTB;MUSuNVYxOiEQvF2= MXPTRW5ITVJ?
MEG-01 MlXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrGTWM2OD1zND6zO|A5KM7:TR?= M2X5NnNCVkeHUh?=
RS4-11 M{LrV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTF2Lke0NkDPxE1? NXr2N4JzW0GQR1XS
MN-60 MnjCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTF2Lke4PVQh|ryP MoLvV2FPT0WU
NCI-H1304 Ml3DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkf6TWM2OD1zNT6wOFI2KM7:TR?= M3rFS3NCVkeHUh?=
Ramos-2G6-4C10 NVjDbVE3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTF3LkC1PFEh|ryP MXLTRW5ITVJ?
NCI-H2342 MmXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHlTWM2OD1zNT6yNFQ1KM7:TR?= NHnLZYlUSU6JRWK=
LAN-6 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLocJJDUUN3ME2xOU41PDF2IN88US=> M2rjOHNCVkeHUh?=
JVM-2 NEHOW3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXjXJVSUUN3ME2xOU42PzR6IN88US=> M3TkR3NCVkeHUh?=
P30-OHK MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFW0XY9KSzVyPUG2MlA3OTRizszN M17WPXNCVkeHUh?=
C-33-A MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUf2T45UUUN3ME2xOk43OjF2IN88US=> NGXWTmFUSU6JRWK=
RPMI-8866 MlP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTF4Lki0PVYh|ryP M4XxcnNCVkeHUh?=
NCI-H630 NGTN[mVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHiTWM2OD1zNj64OVM4KM7:TR?= MWrTRW5ITVJ?
KYSE-140 NVHR[nhzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rYemlEPTB;MUeuNlAzQCEQvF2= MorNV2FPT0WU
T84 NYf4T5JGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{i0bGlEPTB;MUiuPFY6PSEQvF2= NX;Cd216W0GQR1XS
KU-19-19 M1\mfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIe2T2tKSzVyPUG4Mlk3ODhizszN MljDV2FPT0WU
BALL-1 NFSzcpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnuV2FKSzVyPUG5MlM{QTlizszN M{LjZnNCVkeHUh?=
Calu-6 NHjyXm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjwW|NSUUN3ME2xPU41QTJizszN Moi5V2FPT0WU
EGI-1 NGm4NFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7YZ3NKUUN3ME2xPU42QThizszN M4DERnNCVkeHUh?=
MFH-ino MojNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHETWM2OD1zOT63OFU1KM7:TR?= M4m0NXNCVkeHUh?=
GB-1 MmO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnSXYJWUUN3ME2yNE4{PTN3IN88US=> M3vKTXNCVkeHUh?=
NCI-H1693 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrLOW14UUN3ME2yNE43PTB3IN88US=> M4X6[nNCVkeHUh?=
SW1116 MljCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETObHNKSzVyPUKwMlk{PjJizszN MmTKV2FPT0WU
H-EMC-SS NFfNZYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILQR|lKSzVyPUKyMlA1PSEQvF2= NUHlV4pZW0GQR1XS
D-502MG NHXKcGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHP0fmRKSzVyPUKyMlgzPjFizszN NVrCVIp7W0GQR1XS
IA-LM MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTJ|LkK0PVMh|ryP MlP1V2FPT0WU
SW1463 M2jZ[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXf3VlkzUUN3ME2yN{44QSEQvF2= NHrESWdUSU6JRWK=
JAR MnziS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrUTWM2OD1{ND6zNlk{KM7:TR?= NUDpe3c4W0GQR1XS
HT NFLzOmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvGfYhPUUN3ME2yOE41PzV|IN88US=> NEC2UlVUSU6JRWK=
LCLC-103H NGDPSo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlW4TWM2OD1{ND64OFQ6KM7:TR?= M4juUHNCVkeHUh?=
SNU-449 M4nnPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTJ2Lki3OFEh|ryP M1jwNXNCVkeHUh?=
KE-37 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1freWlEPTB;MkWuNFkzQCEQvF2= M{S2cHNCVkeHUh?=
NCI-H1623 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETlc4lKSzVyPUK3MlE{ODNizszN NWTzfFRIW0GQR1XS
MOLT-13 MnewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIq5V3VKSzVyPUK3MlM2OTZizszN M2\rU3NCVkeHUh?=
COLO-741 NGTTSXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjhN|lKSzVyPUOxMlM{OzNizszN MX;TRW5ITVJ?
NB6 M1fue2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTJSHJKSzVyPUOyMlI5PzZizszN NE\YbVlUSU6JRWK=
MOLT-16 M2\RUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknpTWM2OD1|Mz6wNFU2KM7:TR?= NIXZWo5USU6JRWK=
IST-MES1 NEDZNWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTN2LkC1OFEh|ryP M333VHNCVkeHUh?=
A4-Fuk M3nZSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFP3T4VKSzVyPUO1MlA3PiEQvF2= M3;xZnNCVkeHUh?=
CAL-85-1 M2PrNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrsW41SUUN3ME2zOU4zQDF5IN88US=> MnvuV2FPT0WU
CCRF-CEM MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTN5LkG1N|Yh|ryP NVLNW4lbW0GQR1XS
HAL-01 M1ixfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nkZWlEPTB;M{iuOFg5QSEQvF2= NVmxW|lzW0GQR1XS
HEL NHi2eG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{e5R2lEPTB;NEOuN|QxQSEQvF2= M13jTHNCVkeHUh?=
EW-1 NYHXRnJXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIG5WZlKSzVyPUSzMlQ4PjhizszN NHzHcI1USU6JRWK=
MDA-MB-231 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnVWpVxUUN3ME20OU4yOTl7IN88US=> MmG1V2FPT0WU
ABC-1 NVz6eHF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfKSYpKSzVyPUS2Mlg2OzhizszN NF3UVZFUSU6JRWK=
NCI-H446 NETucmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2f1eGlEPTB;NEiuOVA2QCEQvF2= NFvqdlJUSU6JRWK=
MHH-PREB-1 MkTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTDTWM2OD12OT62NFA4KM7:TR?= MofRV2FPT0WU
DOHH-2 Mlq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTR7Lk[2OVYh|ryP Mlu3V2FPT0WU
GCT M2fnXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrjNpZKSzVyPUS5MlY6PzZizszN NYfqRlFQW0GQR1XS

... Click to View More Cell Line Experimental Data

体内研究 17-AAG作用于携带3T3-src, B16或CT26移植瘤裸鼠,与Hsp90结合具有高亲和力,IC50为8-35 nM,而作用于正常组织时,IC50为200-600 nM。[1] 17-AAG按50 mg/kg左右剂量处理,引起AR, HER2, HER3, 和 Akt表达明显降低,降低达50%以上,这种作用存在剂量依赖性,结果导致雄激素依赖型 (CWR22)和非依赖型(CWR22R 和CWRSA6) 前列腺移植瘤生长受抑制,抑制率分别为67%, 80%和 68%。[2]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[1]
+ 展开

Hsp90结合实验:

纯化的Hsp90蛋白或过量表达HER-2的癌细胞(BT474, N87, SKOV3 和 SKBR3) 裂解物或BT474乳腺癌细胞溶于溶解buffer(20 mM HEPES, pH 7.3, 1 mM EDTA, 5 mM MgCl2, 100 mM KCl) ,与不同浓度17-AAG在4oC下温育30分钟,然后和生物素-GM链接的BioMag链霉亲和素磁珠在4oC下温育1小时。试管放置于磁架上,除去未结合的上清液。在溶解buffer中清洗三次磁珠,然后在SDS–PAGE 样本缓冲液中在95oC下加热5分钟。在SDS蛋白凝胶上进行样本分析,使用特点抗体进行Western Blotting。使用Bio-rad Fluor-S 多重图像测量Western Blot条带,计算抑制Hsp90与生物素-GM结合的百分数。测定IC50。
细胞实验:[1]
+ 展开
  • Cell lines: BT474, SKBR3, N87, SKOV3, MCF7, MDA468, Hs578T, Hs578Bst, A549, HT29, U87, SKMG3, HT1080, RPTEC, NDF, HMVEC, HMEC, HUVEC, 和 PBMC
  • Concentrations: 溶于DMSO, 终浓度为10 μM 左右
  • Incubation Time: 5天
  • Method: 细胞按每孔2000个接种在96孔板上,终培养体积为100 μL,培养24小时, 然后加入浓度不断增高的17-AAG,温育5天。使用 Celltiter 96 AQueous 非放射性细胞增殖检测试剂盒测定存活细胞数。测定IC50。
    (Only for Reference)
动物实验:[2]
+ 展开
  • Animal Models: 皮下注射雄激素依赖性CWR22移植瘤的雄性 nu/nu 无胸腺小鼠, 皮下注射雄激素非依赖性的CWR22R和CWRSA6移植瘤的雌性nu/nu 无胸腺小鼠。
  • Formulation: 溶于DMSO, 对照组用蛋磷脂(EPL)稀释
  • Dosages: 50 mg/kg 左右
  • Administration: 腹膜注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 100 mg/mL (170.73 mM)
Ethanol 5 mg/mL (8.53 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5%DMSO+corn oil
10mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 585.69
化学式

C31H43N3O8

CAS号 75747-14-7
稳定性 powder
in solvent
别名 CP127374,NSC-330507, KOS 953

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00577889 Completed Adenocarcinoma of the Pancreas|Recurrent Pancreatic Cancer|Stage IV Pancreatic Cancer National Cancer Institute (NCI) March 2008 Phase 2
NCT00546780 Completed Multiple Myeloma Bristol-Myers Squibb February 2008 Phase 3
NCT00093496 Completed Primary Peritoneal Cavity Cancer|Recurrent Ovarian Epithelial Cancer|Stage III Ovarian Epithelial Cancer|Stage IV Ovarian Epithelial Cancer National Cancer Institute (NCI) October 2007 Phase 2
NCT00514371 Completed Multiple Myeloma Bristol-Myers Squibb August 2007 Phase 2|Phase 3
NCT00779428 Completed Advanced Malignancies Bristol-Myers Squibb July 2006 Phase 2
NCT00354185 Terminated Adult Nasal Type Extranodal NK/T-cell Lymphoma|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Intraocular Lymphoma|Nodal Marginal Zone B-cell Lymphoma|Post-transplant Lymphoproliferative Disorder|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Hodgkin Lymphoma|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Adult T-cell Leukemia/Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Small Intestine Lymphoma|Splenic Marginal Zone Lymphoma|Stage III Adult Burkitt Lymphoma|Stage III Adult Diffuse Large Cell Lymphoma|Stage III Adult Diffuse Mixed Cell Lymphoma|Stage III Adult Diffuse Small Cleaved Cell Lymphoma|Stage III Adult Hodgkin Lymphoma|Stage III Adult Immunoblastic Large Cell Lymphoma|Stage III Adult Lymphoblastic Lymphoma|Stage III Adult T-cell Leukemia/Lymphoma|Stage III Cutaneous T-cell Non-Hodgkin Lymphoma|Stage III Grade 1 Follicular Lymphoma|Stage III Grade 2 Follicular Lymphoma|Stage III Grade 3 Follicular Lymphoma|Stage III Mantle Cell Lymphoma|Stage III Marginal Zone Lymphoma|Stage III Mycosis Fungoides/Sezary Syndrome|Stage III Small Lymphocytic Lymphoma|Stage IV Adult Burkitt Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma|Stage IV Adult Diffuse Mixed Cell Lymphoma|Stage IV Adult Diffuse Small Cleaved Cell Lymphoma|Stage IV Adult Hodgkin Lymphoma|Stage IV Adult Immunoblastic Large Cell Lymphoma|Stage IV Adult Lymphoblastic Lymphoma|Stage IV Adult T-cell Leukemia/Lymphoma|Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma|Stage IV Grade 1 Follicular Lymphoma|Stage IV Grade 2 Follicular Lymphoma|Stage IV Grade 3 Follicular Lymphoma|Stage IV Mantle Cell Lymphoma|Stage IV Marginal Zone Lymphoma|Stage IV Mycosis Fungoides/Sezary Syndrome|Stage IV Small Lymphocytic Lymphoma|Unspecified Adult Solid Tumor Protocol Specific|Waldenström Macroglobulinemia National Cancer Institute (NCI) May 2006 Phase 1

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操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    What kind of subtypes does this compound inhibit? HSP90α or HSP90β ?

  • 回答:

    17-AAG can inhibit both HSP90α and HSP90β, but it is unclear how much are they affected respectively. You should note that Hsp90 derived from tumor cells has a 100-fold higher binding affinity for 17-AAG than that from normal cells according to this paper. http://www.nature.com.ezp-prod1.hul.harvard.edu/nature/journal/v425/n6956/full/nature01913.html

HSP (e.g. HSP90) Signaling Pathway Map

HSP (e.g. HSP90) Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID