Tanespimycin (17-AAG)

目录号:S1141 别名: CP127374,NSC-330507, KOS 953

Tanespimycin (17-AAG) Chemical Structure

Molecular Weight(MW): 585.69

Tanespimycin (17-AAG)是一种有效的HSP90抑制剂,无细胞试验中IC50为5 nM,作用于来自肿瘤细胞的HSP90比作用于来自正常细胞HSP90结合亲和力高100倍。Phase 2。

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RMB 1597.01 现货
RMB 1221.85 现货
RMB 3016.43 现货
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客户使用该产品的9个实验数据:

  • (A) Cell lines were seeded in 96-well plates and treated with 10 nM of 17-AAG for 72 h. Cell survival was analyzed using CellTiter-Glo. Both parental H3122 cells (red bar) and H3122 CR cells (blue bar) show sensitivity to 17-AAG. (B) Suppression of ALK signaling by 17-AAG in resistant H3122 CR cells. H3122 parental and resistant cells were exposed to increasing concentrations of 17-AAG for 6 h.

    PNAS, 2011, 108: 7535-40. Tanespimycin (17-AAG) purchased from Selleck.

    (A) Treatment of DIPG cells with an HSP90 inhibitor, 17-AAG, resulted in decreased invasion toward SVZ hNPC CM at high doses. (B) Cell viability of DIPG cells treated with increasing doses of 17-AAG, by the CellTiter-Glo assay.

    Cell, 2017, 170(5):845-859.e19. Tanespimycin (17-AAG) purchased from Selleck.

  • SKBR3 cells were treated with FW-04-806 at 10, 20, 40 uM for 24 h; 17AAG was used as a positive control at 1 and 2 uM. Hsp70, Hsp90, and Cdc37 protein level were analyzed with western blotting using relevant antibodies.

    Mol Cancer 2014 13, 150. Tanespimycin (17-AAG) purchased from Selleck.

    Western blot analysis of immunoprecipitated Hsp90/BIP complexes in MOLT-4 (T-ALL) and RS4;11 (B-ALL) treated for 22 h with CX-4945 (5 μM) and bortezomib (2.5 nM) either alone or in combination. 500 μg of protein lysates were immunoprecipitated with anti-Hsp90 antibody. Relative Induction values (Rel.Ind.) were obtained by normalizing to Hsp90 bands density. 17-AAG: tanespimycin.

    Oncotarget, 2015, 51: S659-S660. Tanespimycin (17-AAG) purchased from Selleck.

  • Co-IP analyses of direct interaction between HSP90 and HIF-1α in 17-AAG (5 μM)-treated HSCs using antibodies against HSP90, HIF-1α or IgG (n = 2).

    Br J Pharmacol, 2017, 174(5):409-423. Tanespimycin (17-AAG) purchased from Selleck.

    Treatment with an Hsp90 inhibitor results in a dose-dependent decrease in complex IV activity. A, because Hsp90 levels were reduced by 80%, in PINK1 null dopaminergic neuronal cells, the effects of specific inhibition of Hsp90 using 17-AAG were analyzed in wild-type neuronal cells. Both complex IV activity and Hsp60 levels were decreased significantly in 17-AAG-treated cells in a dose-dependent manner. B, in contrast, 17-AAG treatment did not affect expression of Hsp90 and LRPPRC.

    J Biol Chem 2012 287, 44109-20. Tanespimycin (17-AAG) purchased from Selleck.

  • UPR modulators destabilize mSmoM2. NIH 3T3 cells expressing mSmoM2 protein were treated with HSP90 inhibitors 17-AAG (50 uM and 100 uM) and SNX-2112 (25 uM and 50 uM) and the proteasome inhibitor bortezomib (25 uM and 50 uM) for 4 h prior to lysis. DMSO was the vehicle control. Western blotting of whole-cell lysates revealed mSmoM2 protein to be destabilized in response to HSP-90 inhibitors but not in response to bortezomib. Tubulin was the loading control. CHOP results indicate ER stress.

    Mol Cell Biol 2013 33(12), 2375-87. Tanespimycin (17-AAG) purchased from Selleck.

    Hsp90 is up-regulated during aging. Whole-cell extracts were prepared from young (PD 20) and old (PD 40) HFSN1 cells. c HFSN1 cells (PD 40) were treated with different concentration of the Hsp90 inhibitor (17-AAG) and then re-incubated for 24 h. Whole-cell extracts were prepared and analyzed by western blot using the indicated antibodies.

    Age 2013 35, 549-62. Tanespimycin (17-AAG) purchased from Selleck.

  • Four types of the colon cancer cells with indicated K-Ras phenotype were incubated with indicated concentration of 17-AAG for 24 h, which were then analyzed for protein expression by WB.

    Oncotarget 2014 5, 4269-82. Tanespimycin (17-AAG) purchased from Selleck.

产品安全说明书

HSP (e.g. HSP90)抑制剂选择性比较

生物活性

产品描述 Tanespimycin (17-AAG)是一种有效的HSP90抑制剂,无细胞试验中IC50为5 nM,作用于来自肿瘤细胞的HSP90比作用于来自正常细胞HSP90结合亲和力高100倍。Phase 2。
特性 17-AAG对正常细胞的毒性很小。
靶点
HSP90 [1]
(Cell-free assay)
5 nM
体外研究

17-AAG是格尔德霉素类似物, 但是与过量表达HER-2的癌细胞 (BT474, N87, SKOV3 和SKBR3)或BT474乳腺细胞衍生的Hsp90亲和力高100多倍,IC50为5-6 nM, 而作用于正常人类原代细胞时,IC50为400-943 nM, 因为肿瘤Hsp90 处于多伴复合体状态,具有高ATP酶活性,而正常细胞Hsp90 处于潜在未结合状态, 且直接与那些细胞中17-AAG毒性相关。[1]17-AAG 引起HER2, HER3, Akt,突变和野生型雄激素受体(AR)降解,导致前列腺细胞如LNCaP, LAPC-4, DU-145,和PC-3中RB依赖的 G1 期生长停顿,IC50为25-45 nM。[2]除了诱导改变野生型BCR-ABL的Ba/F3细胞凋亡, IC50为5.2 μM, 17-AAG还通过诱导野生型和突变型 BCR-ABL蛋白降解,而诱导改变抗 Imatinib Mesylate的 T315I和 E255K BCR-ABL突变型细胞生长,IC50分别为2.3 μM 和 1.0 μM。[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A549 Ml3mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXsTWM2OD1yLkCwNFMxOyEQvF2= MlnvV2FPT0WU
IST-MEL1 MmnBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jOWWlEPTB;MD6wNFA1ODdizszN MkW2V2FPT0WU
NCI-SNU-1 M{jhTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGq3dlhKSzVyPUCuNFAzODdizszN NYjIN2k{W0GQR1XS
FADU M{fpTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHq1PYlKSzVyPUCuNFAzODlizszN NFPL[ZFUSU6JRWK=
C32 M4HQ[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTBwMECzNFQh|ryP NGTjWGJUSU6JRWK=
D-566MG M4XKXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\2TWM2OD1yLkCwN|kh|ryP MnjKV2FPT0WU
LXF-289 MlfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTBwMEC0NVkh|ryP NVOyWGlLW0GQR1XS
HGC-27 NYP6cnlLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPtTWM2OD1yLkCwOVEh|ryP NILuO5pUSU6JRWK=
RPMI-7951 Mm[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXBUlNKSzVyPUCuNFA4OTdizszN NWLtV5dtW0GQR1XS
HSC-3 NXryW5lsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fq[mlEPTB;MD6wNFkzQSEQvF2= MmnZV2FPT0WU
MIA-PaCa-2 NXSx[mpuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHrPHBqUUN3ME2wMlAyODB7IN88US=> MlrJV2FPT0WU
KS-1 NHvPUllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWCyPZVGUUN3ME2wMlAyOzV3IN88US=> MkDIV2FPT0WU
CAL-51 M2[5b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NICzbHRKSzVyPUCuNFE1ODVizszN MXLTRW5ITVJ?
MDA-MB-361 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rqVmlEPTB;MD6wNVQ6PSEQvF2= MkKwV2FPT0WU
TI-73 NVLJeXpDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHNXpNEUUN3ME2wMlAyPzl4IN88US=> NYj1N2xQW0GQR1XS
AGS NYL0S4ZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPmV3o3UUN3ME2wMlAyQTN6IN88US=> M2fkUnNCVkeHUh?=
NCI-H460 NUfQUVFvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLWTWM2OD1yLkCxPVc1KM7:TR?= NXXBem5mW0GQR1XS
A204 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXuZVZKSzVyPUCuNFIzPDlizszN MlzwV2FPT0WU
CHL-1 M2ew[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPQTWM2OD1yLkCyNlUyKM7:TR?= NYfrRpJSW0GQR1XS
DU-4475 NY\Zc3ByT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWX4Z5BlUUN3ME2wMlAzOjZzIN88US=> MVjTRW5ITVJ?
CGTH-W-1 NVHXNYJGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLwTWM2OD1yLkCyN|Q6KM7:TR?= M1nhNnNCVkeHUh?=
HCC2218 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjURldKSzVyPUCuNFI1QTRizszN Ml7UV2FPT0WU
A2780 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M36xSmlEPTB;MD6wNlU{OSEQvF2= NVrqdlA6W0GQR1XS
NCI-H720 Mk\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHtbFFKSzVyPUCuNFI2PDZizszN NXnXW41IW0GQR1XS
NCI-N87 MnzNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPaTWM2OD1yLkCyOVk{KM7:TR?= MYjTRW5ITVJ?
CHP-212 NFzPVJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjXUmpKSzVyPUCuNFI3OjhizszN M{HTZnNCVkeHUh?=
NCI-H23 Mn\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjrNpBqUUN3ME2wMlAzPjZ3IN88US=> NUTI[2syW0GQR1XS
D-263MG MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHje3F2UUN3ME2wMlAzPzh4IN88US=> NWj5[2RqW0GQR1XS
ME-180 NEnVW|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLtUmxKSzVyPUCuNFI5QTFizszN Mn\iV2FPT0WU
SW982 MoL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwMEK5PVkh|ryP MYXTRW5ITVJ?
OE19 NEL4cZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjxO4dRUUN3ME2wMlA{ODd5IN88US=> M37tOnNCVkeHUh?=
SK-LU-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7D[WZOUUN3ME2wMlA{ODh{IN88US=> MXLTRW5ITVJ?
H4 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PYVGlEPTB;MD6wN|A6KM7:TR?= MmnXV2FPT0WU
HT-144 MoPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknFTWM2OD1yLkCzNFk{KM7:TR?= NYDvS|RxW0GQR1XS
SK-UT-1 MmXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\adWJ7UUN3ME2wMlA{OTd6IN88US=> NEXROJRUSU6JRWK=
D-336MG MkXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVS0bZAyUUN3ME2wMlA{OzB7IN88US=> NEDQdYtUSU6JRWK=
MDA-MB-175-VII M3;1[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXP5cIt4UUN3ME2wMlA{OzV2IN88US=> NY\1PIpWW0GQR1XS
GAMG MmG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTOTWM2OD1yLkCzOFM2KM7:TR?= MWHTRW5ITVJ?
CP50-MEL-B MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37vdWlEPTB;MD6wN|Q2KM7:TR?= NVjFWG9nW0GQR1XS
OVCAR-5 MnGxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPjTWM2OD1yLkCzOFgh|ryP NH7EZoxUSU6JRWK=
SK-MES-1 NELxb3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HyXGlEPTB;MD6wN|YxPiEQvF2= M{XhbXNCVkeHUh?=
VM-CUB-1 NEDvOpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXkXphIUUN3ME2wMlA{PjV5IN88US=> NFTGTWpUSU6JRWK=
WM-115 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{n4d2lEPTB;MD6wN|c3OiEQvF2= M1;0NHNCVkeHUh?=
DSH1 MlXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonYTWM2OD1yLkCzPFA4KM7:TR?= MkXBV2FPT0WU
Becker NVry[pRlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTXTWM2OD1yLkCzPFg2KM7:TR?= MlToV2FPT0WU
SW962 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTBwMEO5OFUh|ryP NICzb|dUSU6JRWK=
TYK-nu M2DT[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLwTWM2OD1yLkCzPVg2KM7:TR?= MYLTRW5ITVJ?
HO-1-N-1 MoOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\BSHk3UUN3ME2wMlA1ODJzIN88US=> NVLzfFNRW0GQR1XS
T98G MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rI[2lEPTB;MD6wOFExOyEQvF2= NV61Rmk5W0GQR1XS
ACN NHHtUXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYK5VHpjUUN3ME2wMlA1OTZ{IN88US=> NW\JWVNNW0GQR1XS
SW780 NUf6Xo9YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fhbWlEPTB;MD6wOFIxOyEQvF2= MVLTRW5ITVJ?
Detroit562 MoX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\JSlQ{UUN3ME2wMlA1OjN7IN88US=> NGnxSHJUSU6JRWK=
BB49-HNC M3TaTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrT[lVKSzVyPUCuNFQzPDNizszN MVTTRW5ITVJ?
HN MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\zcGtFUUN3ME2wMlA1Ojd{IN88US=> NVfrTWp1W0GQR1XS
H9 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTBwMESzO|Eh|ryP MVHTRW5ITVJ?
VA-ES-BJ M3n1bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXlO5BKSzVyPUCuNFQ1PDdizszN NHrNR|dUSU6JRWK=
MEL-JUSO M{TZSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHsNGtKSzVyPUCuNFQ1PzVizszN NVzvfVdDW0GQR1XS
BT-474 M2PMN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUi5Tlg1UUN3ME2wMlA1PSEQvF2= MXTTRW5ITVJ?
CaR-1 NV;FdYZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPPenZKSzVyPUCuNFQ2PDlizszN NHriVXNUSU6JRWK=
PSN1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrMUlRHUUN3ME2wMlA1PjB|IN88US=> NUL3ToRzW0GQR1XS
KYSE-510 NVHLfGV{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILieIlKSzVyPUCuNFQ3PDlizszN M2PCO3NCVkeHUh?=
KP-4 MoG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLxTWM2OD1yLkC0O|U{KM7:TR?= NVvCbGM3W0GQR1XS
KYSE-410 NEDLN|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjiNZNKSzVyPUCuNFQ4PzJizszN NGfPSo9USU6JRWK=
G-402 MlT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHafmJKSzVyPUCuNFQ4QDlizszN NF65PWlUSU6JRWK=
DOK MlPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnixTWM2OD1yLkC0PVAzKM7:TR?= M3L2e3NCVkeHUh?=
COR-L88 NES4UI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTBwMES5NVIh|ryP NXzPRpduW0GQR1XS
SKG-IIIa NVrBeI1UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4T2TmlEPTB;MD6wOFk5PiEQvF2= M4rIUnNCVkeHUh?=
AN3-CA MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHvXJRKSzVyPUCuNFUh|ryP MWLTRW5ITVJ?
SW48 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PyUmlEPTB;MD6wOVA{QSEQvF2= MV3TRW5ITVJ?
YKG-1 M3\RcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXUTWM2OD1yLkC1NFcyKM7:TR?= NF\EWXBUSU6JRWK=
KYSE-150 NFPtT3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzqTWM2OD1yLkC1NlM2KM7:TR?= M1;JZ3NCVkeHUh?=
HuO-3N1 NWe5[|Z4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwMEWyN|ch|ryP MmLFV2FPT0WU
LB1047-RCC MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4H0RmlEPTB;MD6wOVI6PiEQvF2= Mn:xV2FPT0WU
NCI-H2030 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTBwMEW0NVQh|ryP MXvTRW5ITVJ?
YH-13 MmnIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HnZWlEPTB;MD6wOVczOiEQvF2= MUDTRW5ITVJ?
5637 Moq3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\rN242UUN3ME2wMlA2PzRizszN M3\rSHNCVkeHUh?=
LOXIMVI NFXwO2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnoTWM2OD1yLkC1PFczKM7:TR?= MYrTRW5ITVJ?
GT3TKB M1\HeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDpTWM2OD1yLkC1PVQzKM7:TR?= MkjRV2FPT0WU
TCCSUP NUnQcG93T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1flbGlEPTB;MD6wOVk3PCEQvF2= MXLTRW5ITVJ?
EPLC-272H Mm\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVW4[mlHUUN3ME2wMlA3OjB3IN88US=> NXzpPJZyW0GQR1XS
LU-99A NVjKVWYyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXCdmNKSzVyPUCuNFYzOzdizszN MVzTRW5ITVJ?
NCI-H1755 NXfTfJhGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\ITWM2OD1yLkC2N|QyKM7:TR?= NX7afZE6W0GQR1XS
KM12 MnTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwME[zOFgh|ryP MmrTV2FPT0WU
SF295 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFL0VYhKSzVyPUCuNFY1PTJizszN NF7Jco5USU6JRWK=
MZ2-MEL MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLlZmtKSzVyPUCuNFY2PTNizszN NVnudJRiW0GQR1XS
HEC-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPEe2tMUUN3ME2wMlA3PTh6IN88US=> NGfr[4lUSU6JRWK=
SW684 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nKT2lEPTB;MD6wOlU6OSEQvF2= NGfrNW9USU6JRWK=
SF539 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUi0SIJTUUN3ME2wMlA3PjhzIN88US=> NWPXVJFnW0GQR1XS
GMS-10 NUmwem5iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;PU5gyUUN3ME2wMlA3Pjl7IN88US=> M2LBSXNCVkeHUh?=
MV-4-11 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTBwME[4NFMh|ryP M2j6PXNCVkeHUh?=
HT-29 NW\UU41VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\ERnV1UUN3ME2wMlA3QTF7IN88US=> Ml3wV2FPT0WU
23132-87 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDKT5R5UUN3ME2wMlA3QTVizszN NGDZVmFUSU6JRWK=
SW620 M1zBb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrScHhCUUN3ME2wMlA4ODJ4IN88US=> M{HHdnNCVkeHUh?=
HCC1806 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTBwMEexN|Eh|ryP NUjhOIFKW0GQR1XS
Hs-578-T NEPrPIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HZemlEPTB;MD6wO|IxQCEQvF2= M2[3UXNCVkeHUh?=
A2058 NX\rZVhFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjUO49IUUN3ME2wMlA4OjJ6IN88US=> M33ab3NCVkeHUh?=
MEL-HO NETFVXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fa[GlEPTB;MD6wO|I2PSEQvF2= MV;TRW5ITVJ?
HCC2998 MoLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rjbGlEPTB;MD6wO|M1PyEQvF2= Mo\JV2FPT0WU
HuO9 NX3R[mdxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nvR2lEPTB;MD6wO|U5QSEQvF2= MkTPV2FPT0WU
CAL-39 NVS4dHV5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvBUHpKSzVyPUCuNFc4PjZizszN NXfCcXFjW0GQR1XS
M14 NHnYNVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LjWmlEPTB;MD6wO|kyOyEQvF2= NVjEdGNEW0GQR1XS
BFTC-909 NVnFOFFGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXuwXZBCUUN3ME2wMlA4QTZ7IN88US=> MoezV2FPT0WU
TE-11 NFjRW41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVv3Z3IzUUN3ME2wMlA4QTl4IN88US=> NUPrTYtpW0GQR1XS
TGBC1TKB NX;5ephzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Da[WlEPTB;MD6wPFA1OyEQvF2= MmTqV2FPT0WU
L-363 Ml3TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPXOo5KSzVyPUCuNFgzODZizszN NYL0dmJRW0GQR1XS
A431 NUDGU5FYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIThO3pKSzVyPUCuNFgzOSEQvF2= MVrTRW5ITVJ?
MKN45 NFfRVmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fYRmlEPTB;MD6wPFIyQSEQvF2= NEL4SFFUSU6JRWK=
HT-1080 MoX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4H3W2lEPTB;MD6wPFQ{QSEQvF2= MXzTRW5ITVJ?
OVCAR-8 M1P5[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwMEi2NlIh|ryP NV3zb4RoW0GQR1XS
LCLC-97TM1 NGPZUXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnwTlk{UUN3ME2wMlA5PzJ6IN88US=> M4\zbnNCVkeHUh?=
M059J MonkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXrTWM2OD1yLkC5NFI4KM7:TR?= NYfB[YdNW0GQR1XS
SK-MEL-2 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfoVZU3UUN3ME2wMlA6ODZizszN MVvTRW5ITVJ?
TE-1 NVTMSIZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7tPY5KSzVyPUCuNFkzODRizszN NF[1RXhUSU6JRWK=
KYSE-180 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWn6O5RlUUN3ME2wMlA6OjZ{IN88US=> M4\uUHNCVkeHUh?=
D-247MG NYKyOWR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2G2T2lEPTB;MD6wPVQ2PSEQvF2= M4\MbHNCVkeHUh?=
8-MG-BA MnT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XRV2lEPTB;MD6wPVQ4OiEQvF2= MlS1V2FPT0WU
NCI-H1792 NIPrVItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDPNoZZUUN3ME2wMlA6PjF6IN88US=> MlPBV2FPT0WU
MCF7 M1PueGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTBwMEm2O|ch|ryP MU\TRW5ITVJ?
NCI-H2122 NGLBUmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTBwMEm3OFUh|ryP NH7RXYlUSU6JRWK=
EFO-27 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTHN5BKSzVyPUCuNFk6QTdizszN NV7yd2RzW0GQR1XS
LB2241-RCC MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3ezOmlEPTB;MD6xNFA2PCEQvF2= NH\LdlJUSU6JRWK=
SN12C NYn6PFF5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTBwMUCxNFch|ryP MlH0V2FPT0WU
A498 NGPtSW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWixXpl3UUN3ME2wMlExOThizszN NWfUVFdHW0GQR1XS
PANC-03-27 Mn\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3nfFNKSzVyPUCuNVAzQDZizszN MmG3V2FPT0WU
NCI-H1581 NH\pXWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwMUCyPUDPxE1? NFe2V|lUSU6JRWK=
U-87-MG MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlS0TWM2OD1yLkGwN|A4KM7:TR?= MX3TRW5ITVJ?
G-401 NWCydWtRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{K0fGlEPTB;MD6xNFM2OyEQvF2= NWH0Z2JiW0GQR1XS
SiHa MnTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTBwMUC0PFYh|ryP NFPtc5FUSU6JRWK=
U251 NXXxdWZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjlNGczUUN3ME2wMlExPTJ3IN88US=> NUTONYNlW0GQR1XS
MMAC-SF M37ufWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\lN21ZUUN3ME2wMlExPTNzIN88US=> NVzjbVRVW0GQR1XS
BB65-RCC NIrD[JFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUf5dmk6UUN3ME2wMlExPTV2IN88US=> MW\TRW5ITVJ?
NKM-1 NXSwTlZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjITWM2OD1yLkGwOlY3KM7:TR?= M2S5cnNCVkeHUh?=
HD-MY-Z NY\2eFVHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TEVWlEPTB;MD6xNFg4OyEQvF2= MnXaV2FPT0WU
TGBC11TKB NVvjdlFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLwTmFZUUN3ME2wMlExQTB|IN88US=> M3;tSHNCVkeHUh?=
COLO-679 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fse2lEPTB;MD6xNVIyOSEQvF2= NUXiXm1HW0GQR1XS
TE-8 NX\jVYwyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HGW2lEPTB;MD6xNVI3PCEQvF2= NXT3TYJ{W0GQR1XS
SK-MEL-28 M2HmOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTMSlA{UUN3ME2wMlEyOzJzIN88US=> MYPTRW5ITVJ?
SH-4 MoL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfSTWM2OD1yLkGxN|U3KM7:TR?= NYjD[ZJ3W0GQR1XS
KALS-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWG0[JhTUUN3ME2wMlEyOzl|IN88US=> NXzZS5E6W0GQR1XS
RKO Mn:5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nOeGlEPTB;MD6xNVc3PCEQvF2= NILlU5JUSU6JRWK=
OMC-1 NH\GUGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDo[HlKSzVyPUCuNVE4QTdizszN M1viVHNCVkeHUh?=
BT-549 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljLTWM2OD1yLkGxO|k6KM7:TR?= NXKyUY1XW0GQR1XS
NCI-H28 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTBwMUG4NVch|ryP MlrUV2FPT0WU
RXF393 NHTFSIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwMUG5PFIh|ryP NWqzdZVxW0GQR1XS
COLO-829 M{TtWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTBwMUKwNFUh|ryP MYTTRW5ITVJ?
HMV-II MoS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzvc4pSUUN3ME2wMlEzODJizszN NVrEN|FnW0GQR1XS
SW1990 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwMUKxOVch|ryP NGD3T2JUSU6JRWK=
NCI-H1437 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HMRWlEPTB;MD6xNlE2PyEQvF2= NFvEWZNUSU6JRWK=
SNB75 NFe1N4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLSWFZGUUN3ME2wMlEzOTZ7IN88US=> Mmi4V2FPT0WU
EW-3 NFjjNZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDEPXpKSzVyPUCuNVI3PjFizszN M3;ae3NCVkeHUh?=
SAS MnSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfaWYZKSzVyPUCuNVI3QSEQvF2= M4XM[nNCVkeHUh?=
NCI-H1666 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE[2eIRKSzVyPUCuNVI4PzRizszN NXjZOlJXW0GQR1XS
A375 NEDycZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEf3eGNKSzVyPUCuNVI4PzhizszN MYDTRW5ITVJ?
CAMA-1 Mn;WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHlVG1KSzVyPUCuNVI6OjRizszN Ml;tV2FPT0WU
HuP-T4 NGPURXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jYdGlEPTB;MD6xNlk1OyEQvF2= M{m4eHNCVkeHUh?=
NCI-H292 NYO3fpNIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17oRmlEPTB;MD6xN|EyKM7:TR?= NEPJXVBUSU6JRWK=
PC-14 NUjJNWRkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1n3Z2lEPTB;MD6xN|IyOSEQvF2= MUPTRW5ITVJ?
BPH-1 Moe1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITONXJKSzVyPUCuNVM1OSEQvF2= M1j5bXNCVkeHUh?=
GAK NFzvPHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHoRZJmUUN3ME2wMlE{PTZ5IN88US=> NWfrdlM4W0GQR1XS
VMRC-RCZ M3nRZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rCN2lEPTB;MD6xN|c3OiEQvF2= MoXXV2FPT0WU
SK-MEL-24 MnPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjhVHA4UUN3ME2wMlE{QDdizszN M1j1VHNCVkeHUh?=
LB831-BLC MoHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1f4bWlEPTB;MD6xN|g5OyEQvF2= MnTzV2FPT0WU
NCI-H2452 NIrkb4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDpTWM2OD1yLkGzPVU3KM7:TR?= MkXEV2FPT0WU
RT-112 M4TGV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\qS2dKSzVyPUCuNVQxOzVizszN MX;TRW5ITVJ?
GP5d MonSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTBwMUSxNFQh|ryP MVPTRW5ITVJ?
LC-2-ad MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nQOWlEPTB;MD6xOFEzOSEQvF2= MWDTRW5ITVJ?
MPP-89 M1HZbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlL1TWM2OD1yLkG0NVI2KM7:TR?= MY\TRW5ITVJ?
NUGC-3 NFPtZ5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTBwMUS0O|gh|ryP MX\TRW5ITVJ?
GI-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTBwMUS1OVgh|ryP NGmyd4RUSU6JRWK=
HCC1419 NFrwUGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfOTWM2OD1yLkG0OVc3KM7:TR?= NH;POldUSU6JRWK=
SW1573 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4frU2lEPTB;MD6xOFc2QCEQvF2= M1\lNHNCVkeHUh?=
NCI-H2347 M2OxZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofUTWM2OD1yLkG0PFM6KM7:TR?= NIn3epNUSU6JRWK=
Mewo M{\md2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTLTWM2OD1yLkG0PFg6KM7:TR?= NYP4PZFXW0GQR1XS
639-V NYrhSGE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4W2cmlEPTB;MD6xOVAyOyEQvF2= M1LwSXNCVkeHUh?=
AsPC-1 NYLF[WxzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3hVGtKSzVyPUCuNVUzOjVizszN NILHTllUSU6JRWK=
NCI-H1648 Mkj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXpTGFKSzVyPUCuNVUzOzJizszN MX7TRW5ITVJ?
786-0 MnPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlWyTWM2OD1yLkG1N|gyKM7:TR?= MUHTRW5ITVJ?
ETK-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPLfZlKSzVyPUCuNVU6KM7:TR?= MofBV2FPT0WU
BxPC-3 NVLIbFYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLrTWM2OD1yLkG1PVY3KM7:TR?= NELzXVhUSU6JRWK=
CAL-62 NXHsbpN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULoR49mUUN3ME2wMlE3OTZ7IN88US=> MkXjV2FPT0WU
HCC1937 M1zV[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTBwMU[yO|Uh|ryP Mn;3V2FPT0WU
NCI-H1299 M3HzXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTBwMU[yPFUh|ryP M4fPNnNCVkeHUh?=
SW1088 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\rTWM2OD1yLkG2OFE{KM7:TR?= NWKw[|JRW0GQR1XS
FTC-133 NILmXWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwMU[1OEDPxE1? NIjlUJBUSU6JRWK=
OC-314 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTBwMU[2PUDPxE1? NVHrR2F5W0GQR1XS
SCC-9 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHTTWM2OD1yLkG2O|E3KM7:TR?= MVPTRW5ITVJ?
HT-1376 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvHTWM2OD1yLkG2PVM3KM7:TR?= NEfadHVUSU6JRWK=
U-2-OS NF\wb45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HRR2lEPTB;MD6xO|E4OyEQvF2= MoXaV2FPT0WU
COLO-824 M12wUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPVe2dCUUN3ME2wMlE4Ojl2IN88US=> M3HBXXNCVkeHUh?=
BB30-HNC NYXkcGZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTBwMUezN{DPxE1? NYPQSmJyW0GQR1XS
NCI-H2087 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3q2OGlEPTB;MD6xO|M3QCEQvF2= MXfTRW5ITVJ?
NCI-H2170 NV\1XHMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\hfo9KSzVyPUCuNVc2OzZizszN MoixV2FPT0WU
SK-OV-3 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmT1TWM2OD1yLkG3OVcyKM7:TR?= NFGyTmZUSU6JRWK=
MZ7-mel MnjhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn[3TWM2OD1yLkG3OlQ6KM7:TR?= Ml;vV2FPT0WU
NCI-H650 MoHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXJcpZKSzVyPUCuNVc3QDJizszN NVPCdZJQW0GQR1XS
KOSC-2 NIruS4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTBwMUe3N|Qh|ryP MoqxV2FPT0WU
SCC-4 M2HROmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\XTWM2OD1yLkG3O|c4KM7:TR?= M3HmRXNCVkeHUh?=
MDA-MB-157 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4T3PGlEPTB;MD6xPFA5OiEQvF2= NVHTfYZwW0GQR1XS
KYSE-520 M2jQe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwMUiyJO69VQ>? NFrMT5NUSU6JRWK=
LK-2 M1XINGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTmTWM2OD1yLkG4N|A{KM7:TR?= NUfwR5Q6W0GQR1XS
KNS-81-FD M1LDXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXK0[ZR4UUN3ME2wMlE5Ozl2IN88US=> MnO5V2FPT0WU
IGROV-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXTcHpKSzVyPUCuNVg1PDNizszN NVrZd4JkW0GQR1XS
DEL NHLzR5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTBwMUi0OUDPxE1? M1O3TnNCVkeHUh?=
NCI-H1395 NFfoRXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHWxO4NKSzVyPUCuNVg3QDJizszN MXPTRW5ITVJ?
JEG-3 NGDVOGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrESlFKSzVyPUCuNVg4ODVizszN NV3YTpVkW0GQR1XS
BCPAP MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NED4TmtKSzVyPUCuNVg5PzJizszN M4K3b3NCVkeHUh?=
CAL-27 M{PYRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPHTWM2OD1yLkG5NFIzKM7:TR?= NWLOZpA3W0GQR1XS
RD M{TXZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3q3ZWlEPTB;MD6xPVEyOyEQvF2= MVrTRW5ITVJ?
RVH-421 NV24Rnd1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3qVolKSzVyPUCuNVkyOTZizszN NUm1dpZqW0GQR1XS
Capan-2 NFvnfpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHX6fIlKSzVyPUCuNVkzPTZizszN NITSdVZUSU6JRWK=
COLO-680N MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrQeZlYUUN3ME2wMlE6OzZ2IN88US=> NVHzeHE2W0GQR1XS
NCI-H1650 NIHXelVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVP4O2JRUUN3ME2wMlIxODV5IN88US=> MmfEV2FPT0WU
SBC-5 MlvjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLyTWM2OD1yLkKwNVE5KM7:TR?= MnjRV2FPT0WU
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RPMI-8226 M1LYU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HQbWlEPTB;MD62OlMzOyEQvF2= M1GxXHNCVkeHUh?=
MKN28 NVXT[JJKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vWT2lEPTB;MD62OlYzPCEQvF2= NUPteVF6W0GQR1XS
MDA-MB-453 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4[5V2lEPTB;MD62O|E5KM7:TR?= MkLMV2FPT0WU
BV-173 M1rmTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\XfmlEPTB;MD62PFY4QSEQvF2= MmTZV2FPT0WU
NCI-H358 NVHS[JhET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLoW2pQUUN3ME2wMlY5PzJ4IN88US=> MmnZV2FPT0WU
NCI-H1651 MnywS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLtbYZCUUN3ME2wMlch|ryP MnLoV2FPT0WU
MDA-MB-415 M{nBWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fpSmlEPTB;MD63NFgzQSEQvF2= M3fzZXNCVkeHUh?=
8305C NF6z[JJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nCPWlEPTB;MD63NlQ6QCEQvF2= MV7TRW5ITVJ?
EFM-19 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXTTWM2OD1yLkezOlcyKM7:TR?= M1raWXNCVkeHUh?=
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A388 MoLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmniTWM2OD1yLke2OFY4KM7:TR?= M2Tnc3NCVkeHUh?=
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IGR-1 Mlv0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrwdIx1UUN3ME2wMlc6ODR|IN88US=> NW\KeWQ5W0GQR1XS
LNCaP-Clone-FGC MojjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnyzTWM2OD1yLkiwNFA1KM7:TR?= MXnTRW5ITVJ?
SK-MEL-3 NV3xXmdwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTBwOEG1NFgh|ryP NIW2fIxUSU6JRWK=
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NCI-H2009 NHz0bJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGP2b2JKSzVyPUCuPFU{OTFizszN MXPTRW5ITVJ?
NCI-H522 MmPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILHbW5KSzVyPUCuPFc4QDNizszN NFrFW5VUSU6JRWK=
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NB17 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXDUoJlUUN3ME2wMlg5ODJ3IN88US=> NEjwRZlUSU6JRWK=
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LU-65 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTBwOUK1PVEh|ryP MWXTRW5ITVJ?
NCI-H1563 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUe4c4tpUUN3ME2wMlk1QDZ3IN88US=> MlL6V2FPT0WU
KURAMOCHI MnnJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1z6dmlEPTB;MD65OVE6OiEQvF2= MV7TRW5ITVJ?
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NCI-H69 Ml3mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{P2dmlEPTB;MD65O|Y{PCEQvF2= Ml3TV2FPT0WU
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RCM-1 MlzaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3tdJJTUUN3ME2xMlA2PTB5IN88US=> NYLTUYVjW0GQR1XS
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SK-PN-DW MlizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33rcWlEPTB;MT6xNFA2PiEQvF2= M1rjRXNCVkeHUh?=
NCI-H727 M{HVSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXqc4pyUUN3ME2xMlExOTV2IN88US=> M1n0VnNCVkeHUh?=
SW837 NWjqTZdyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTFwMUC5OVQh|ryP MWLTRW5ITVJ?
BT-20 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;mVmJKSzVyPUGuNVEzODRizszN M{PiS3NCVkeHUh?=
RH-18 M3fEUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2WwcGlEPTB;MT6xN|ExOyEQvF2= MkL0V2FPT0WU
TE-12 Ml60S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\sUWRLUUN3ME2xMlE{OzN|IN88US=> M37INnNCVkeHUh?=
NB10 MnTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfOTWM2OD1zLkGzN|Q1KM7:TR?= NGfBeodUSU6JRWK=
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DJM-1 M4\vXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3aTmtWUUN3ME2xMlE6QDhzIN88US=> NUDJUXNlW0GQR1XS
HH MlzZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjRTWM2OD1zLkKzPFMyKM7:TR?= M2PuWXNCVkeHUh?=
LAMA-84 MlzjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3mNZVKSzVyPUGuNlc{QTRizszN MVvTRW5ITVJ?
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NCI-H2052 NUfDcFdKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTFwM{C1NFch|ryP MonVV2FPT0WU
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NCI-H1838 NGHTc5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\ud4NKSzVyPUGuN|Y{ODZizszN M1LtOHNCVkeHUh?=
NCI-H526 NWHYN4Y5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTFwM{e4OVMh|ryP MVTTRW5ITVJ?
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HDLM-2 Ml3oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTFwM{myO|Eh|ryP MVnTRW5ITVJ?
MC-IXC M1XKcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTFwNEKzO|Eh|ryP MV3TRW5ITVJ?
HCT-15 M13D[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTFwNEOwOlgh|ryP NEmxS2dUSU6JRWK=
NCI-H596 NWTUUmNHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTFwNEWwOlEh|ryP M2rmfHNCVkeHUh?=
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A704 NIn3R|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTFwNk[1OlMh|ryP MoTMV2FPT0WU
OVCAR-4 MofTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDpTWM2OD1zLk[5OlA4KM7:TR?= MYTTRW5ITVJ?
SW1417 MlHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvaTWM2OD1zLkeyPFQ6KM7:TR?= NI\Ob4NUSU6JRWK=
CAS-1 NFXXc|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTFwN{O5N|Yh|ryP NUTodYpOW0GQR1XS
IST-SL1 NEPVe2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTFwN{m3OVkh|ryP NYnxNGVvW0GQR1XS
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EW-16 MnTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HzXWlEPTB;MT64Nlg4PSEQvF2= NUnJPGh7W0GQR1XS
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NCI-H226 Mn;xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVf3[4xnUUN3ME2xMlg6OzV7IN88US=> NEf1WllUSU6JRWK=
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NCI-H441 MkPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHheXF4UUN3ME2yMlAzOzN5IN88US=> MlT5V2FPT0WU
LU-139 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnSO|FKSzVyPUKuNFMyOTRizszN MX7TRW5ITVJ?
SJRH30 NHfYR3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjrUoVWUUN3ME2yMlA1OjV|IN88US=> NIP5eZpUSU6JRWK=
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LB771-HNC MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXaTWM2OD1{LkKwOVk2KM7:TR?= M3LSfnNCVkeHUh?=
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EW-22 MmG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfZb3lKSzVyPUKuPVI5PDFizszN MojPV2FPT0WU
DB MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LKUGlEPTB;Mj65O|c2QSEQvF2= MmrrV2FPT0WU
HL-60 M3;qcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPUTWM2OD1|LkC0N|c3KM7:TR?= NIjYU2FUSU6JRWK=
SK-N-DZ MojRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnWfYRKSzVyPUOuNFUxPzVizszN M{e4SnNCVkeHUh?=
NY NF[zSFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPs[m5KSzVyPUOuNFg2PDJizszN NEDJSJVUSU6JRWK=
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NCI-H2029 MnewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1qxcWlEPTB;Mz6yNlQ4PyEQvF2= MWPTRW5ITVJ?
KARPAS-299 MlzRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fVNWlEPTB;Mz6yOlAzPyEQvF2= MV;TRW5ITVJ?
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ALL-PO MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTNwNkKzN|Uh|ryP NV;LZ4MzW0GQR1XS
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CAL-54 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzUVnBKSzVyPUSuNFU6OSEQvF2= NYP0fYliW0GQR1XS
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NCI-H209 MnTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnndZVKSzVyPUSuNlk6QTlizszN M1fuSHNCVkeHUh?=
NOMO-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PxPGlEPTB;ND6zNlE{OSEQvF2= NWPRXnJIW0GQR1XS
RPMI-2650 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTRwM{[zNlch|ryP M4ixXXNCVkeHUh?=
NCI-H810 NHrxPW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M372b2lEPTB;ND6zPVc{PiEQvF2= NHzOPWpUSU6JRWK=
Ca9-22 NETaPVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfGTWM2OD12LkS1OlkyKM7:TR?= NYDWZnZoW0GQR1XS
ES4 MnrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjQTWM2OD12LkS3NFk2KM7:TR?= NXr5blM5W0GQR1XS
ES6 MljnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkSzTWM2OD12LkS5OlU4KM7:TR?= NVzLbJo{W0GQR1XS
DMS-114 MnPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nTVGlEPTB;ND61OFY6OSEQvF2= NILEfFhUSU6JRWK=
ONS-76 M33N[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3j5dWlEPTB;ND61O|k2KM7:TR?= NWTxfVczW0GQR1XS
K-562 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULyeVExUUN3ME20Mlc{QDF2IN88US=> NH7KZnNUSU6JRWK=
MHH-NB-11 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVr0T5ZpUUN3ME20Mlc2PDZzIN88US=> M1LyWnNCVkeHUh?=
Calu-3 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkj1TWM2OD12Lke4OVQ5KM7:TR?= MVHTRW5ITVJ?
HT55 M3XqVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV33O5RpUUN3ME20Mlg1PTR3IN88US=> NIO1[mJUSU6JRWK=
SK-N-FI MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rNT2lEPTB;ND64OVAxQSEQvF2= NETwSFNUSU6JRWK=
ES1 M3\vWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFW5TpBKSzVyPUSuPFYxPTdizszN NFz2fmZUSU6JRWK=
SF126 NFHRUHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TIeWlEPTB;ND65N|E5PCEQvF2= MmS5V2FPT0WU
ES5 NXzJb2JzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHOeVJKUUN3ME21MlEzPDJ5IN88US=> NInuZ2tUSU6JRWK=
LoVo NGLjOmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn[wTWM2OD13LkG1PFcyKM7:TR?= MX3TRW5ITVJ?
SNU-387 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXToZpF7UUN3ME21MlMzOzN7IN88US=> M4q5XXNCVkeHUh?=
C8166 Ml;VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDqZoxKSzVyPUWuN|Y{OzlizszN MnzmV2FPT0WU
LS-1034 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLRUXpbUUN3ME21MlQzOzB5IN88US=> M{\hWXNCVkeHUh?=
GR-ST M2H3V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETwendKSzVyPUWuOVIzODFizszN NV\ZXI5PW0GQR1XS
NCI-H1092 M3XWZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mki5TWM2OD13LkeyPFQ{KM7:TR?= NEexT4ZUSU6JRWK=
647-V M3e3fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDzTWM2OD13Lke0O|A3KM7:TR?= MkXZV2FPT0WU
EW-13 Mm\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NED2VmhKSzVyPUWuO|Y3OjdizszN NF\1[FBUSU6JRWK=
KGN MlPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXUZW9KSzVyPU[uNFk6OjFizszN MnjuV2FPT0WU
D-423MG MlfzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTZwNECyPFQh|ryP MoTZV2FPT0WU
ECC10 NFW3NYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3JXZVKSzVyPUeuNVAyODFizszN Mn3jV2FPT0WU
TE-5 MlHkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfKT21KSzVyPUeuOFEzQThizszN NF6zUpZUSU6JRWK=
P12-ICHIKAWA NEnqUnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlq1TWM2OD15LkS1OVI{KM7:TR?= NHPBTnJUSU6JRWK=
NCI-H82 NGjPOYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTdwNEW3NFEh|ryP MYXTRW5ITVJ?
NCI-H1993 M1v1Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPsWZFKSzVyPUeuPFMxPjNizszN MU\TRW5ITVJ?
RH-1 MlHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jNS2lEPTB;Nz64OVI1PCEQvF2= M2SyUnNCVkeHUh?=
SW948 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUGzXGpSUUN3ME23Mlk3ODR7IN88US=> NH;ncG1USU6JRWK=
CAL-33 NF3tT5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XMUmlEPTB;Nz65PVk{QCEQvF2= M1HsZXNCVkeHUh?=
U-266 NEnzO|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRThwMUW3O|ch|ryP NVvIeIJsW0GQR1XS
CAL-72 NWG2W3Y6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7ETWM2OD16LkKwN|Ih|ryP M2exW3NCVkeHUh?=
SNU-423 M2W5NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;1[mlEPTB;OT6zOlY3PiEQvF2= MmHCV2FPT0WU
KG-1 Ml36S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFGzeFBKSzVyPUmuOVg1PTZizszN MoHNV2FPT0WU
HCC1395 NFPRW|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fVcGlEPTB;OT65NlM2OiEQvF2= MoPlV2FPT0WU
BE-13 NIe2Wo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzPTWM2OD1zMD64PFkzKM7:TR?= MUHTRW5ITVJ?
MKN7 NX\rSoJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzqZ3pKSzVyPUGwMlk4PjVizszN MmPOV2FPT0WU
697 M1TYS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjKfY84UUN3ME2xNU4yPDd{IN88US=> Mnm2V2FPT0WU
LU-135 NXfJcHlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIflNJhKSzVyPUGxMlI{ODdizszN M2jkcHNCVkeHUh?=
ES7 M3PhWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TVZ2lEPTB;MUGuN|MyOyEQvF2= MkTsV2FPT0WU
SK-HEP-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrtTWM2OD1zMT63OlQ3KM7:TR?= NFvYUZJUSU6JRWK=
BEN MnSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHqb2hKSzVyPUGxMlg2OSEQvF2= MXzTRW5ITVJ?
NCI-H1770 NIr1[GJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLuTWM2OD1zMj6xNlYh|ryP M4PhbnNCVkeHUh?=
SW13 NVj4[ZZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfy[pBKSzVyPUGyMlE2PDFizszN M1TVN3NCVkeHUh?=
MZ1-PC NXmwbIJPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInUUGVKSzVyPUGyMlU1PTJizszN Mnz3V2FPT0WU
Mo-T MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoruTWM2OD1zMj63OFIyKM7:TR?= MlnUV2FPT0WU
HLE MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTF{LkiyNVUh|ryP NVGwfXIzW0GQR1XS
RCC10RGB NH;x[WpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jKPGlEPTB;MUOuOlcyKM7:TR?= M4nVRXNCVkeHUh?=
COLO-320-HSR MoXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTF|LkezPFEh|ryP NFv1PFZUSU6JRWK=
BHT-101 NVi0RWFFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTF|LkizOFUh|ryP MV7TRW5ITVJ?
OCUB-M MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\3TWM2OD1zND6xOlAzKM7:TR?= NYf1VndWW0GQR1XS
MEG-01 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1yxTWlEPTB;MUSuN|cxQCEQvF2= MUTTRW5ITVJ?
RS4-11 NXSzXYxlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nR[GlEPTB;MUSuO|QzKM7:TR?= NVXFTXg6W0GQR1XS
MN-60 MnrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvPUI9kUUN3ME2xOE44QDl2IN88US=> MUDTRW5ITVJ?
NCI-H1304 NF;2bI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTF3LkC0NlUh|ryP Mk\6V2FPT0WU
Ramos-2G6-4C10 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTXTWM2OD1zNT6wOVgyKM7:TR?= NHixXoNUSU6JRWK=
NCI-H2342 NGfqVXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\OfVRCUUN3ME2xOU4zODR2IN88US=> M3jtVXNCVkeHUh?=
LAN-6 NVL2W2dqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDUe21GUUN3ME2xOU41PDF2IN88US=> M{nTNnNCVkeHUh?=
JVM-2 M4LyRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfMTWM2OD1zNT61O|Q5KM7:TR?= NX;GZpFXW0GQR1XS
P30-OHK Mne3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fDTGlEPTB;MU[uNFYyPCEQvF2= NIPNZnlUSU6JRWK=
C-33-A M4P5bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVm4b4xOUUN3ME2xOk43OjF2IN88US=> NFfMd2xUSU6JRWK=
RPMI-8866 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLETWM2OD1zNj64OFk3KM7:TR?= NH7PUWdUSU6JRWK=
NCI-H630 NXXXcnU1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGKwNIlKSzVyPUG2Mlg2OzdizszN NIP6[lhUSU6JRWK=
KYSE-140 NVjUdFJmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLpNGlRUUN3ME2xO{4zODJ6IN88US=> NEfxRllUSU6JRWK=
T84 NWPyV4x2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYf6[2RnUUN3ME2xPE45Pjl3IN88US=> NYS0TVRDW0GQR1XS
KU-19-19 NVnJS4RVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fnPWlEPTB;MUiuPVYxQCEQvF2= NVHVVpJiW0GQR1XS
BALL-1 NWK2UnpVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPsN5dKSzVyPUG5MlM{QTlizszN MmXqV2FPT0WU
Calu-6 NUXp[ndCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTF7LkS5NkDPxE1? MVrTRW5ITVJ?
EGI-1 M4OxVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DsSWlEPTB;MUmuOVk5KM7:TR?= MmW5V2FPT0WU
MFH-ino MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHmTWM2OD1zOT63OFU1KM7:TR?= MnzOV2FPT0WU
GB-1 MnrzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTJyLkO1N|Uh|ryP MVzTRW5ITVJ?
NCI-H1693 Mlj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUD2VoxuUUN3ME2yNE43PTB3IN88US=> NEewWoZUSU6JRWK=
SW1116 MofiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnL0TWM2OD1{MD65N|YzKM7:TR?= NYLjU3M6W0GQR1XS
H-EMC-SS MmC4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPheGpKSzVyPUKyMlA1PSEQvF2= MW\TRW5ITVJ?
D-502MG NXH5RmFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYT4eIhKUUN3ME2yNk45OjZzIN88US=> M3;MdHNCVkeHUh?=
IA-LM MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHpTWM2OD1{Mz6yOFk{KM7:TR?= M334VXNCVkeHUh?=
SW1463 NHP6OW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETuZ2NKSzVyPUKzMlc6KM7:TR?= NV;WZZFQW0GQR1XS
JAR NXfCUpljT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTJ2LkOyPVMh|ryP MYLTRW5ITVJ?
HT NEjxVWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfRTWM2OD1{ND60O|U{KM7:TR?= NF3VeWtUSU6JRWK=
LCLC-103H NIe0SFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\CTWM2OD1{ND64OFQ6KM7:TR?= MVXTRW5ITVJ?
SNU-449 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3jTWM2OD1{ND64O|QyKM7:TR?= MVfTRW5ITVJ?
KE-37 M4\MSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn[3TWM2OD1{NT6wPVI5KM7:TR?= MmXIV2FPT0WU
NCI-H1623 M3jtZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jhemlEPTB;MkeuNVMxOyEQvF2= NX7wSlZCW0GQR1XS
MOLT-13 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTJ5LkO1NVYh|ryP NX\MeXJxW0GQR1XS
COLO-741 Mlj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTNzLkOzN|Mh|ryP Ml\qV2FPT0WU
NB6 NULwXJZ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnuRoVIUUN3ME2zNk4zQDd4IN88US=> NFLjNmZUSU6JRWK=
MOLT-16 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLJTWM2OD1|Mz6wNFU2KM7:TR?= NV[5WIZzW0GQR1XS
IST-MES1 NVHyWpZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;ofJhKSzVyPUO0MlA2PDFizszN MonCV2FPT0WU
A4-Fuk NG\HXItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTN3LkC2OkDPxE1? M{WxT3NCVkeHUh?=
CAL-85-1 NYDrUGdjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTN3LkK4NVch|ryP MXrTRW5ITVJ?
CCRF-CEM NVrsTIc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTN5LkG1N|Yh|ryP MkL1V2FPT0WU
HAL-01 MkXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HvNmlEPTB;M{iuOFg5QSEQvF2= MWfTRW5ITVJ?
HEL NUjKOXR{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXyTXc2UUN3ME20N{4{PDB7IN88US=> NH\Cc|ZUSU6JRWK=
EW-1 M1HPbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TRNGlEPTB;NEOuOFc3QCEQvF2= NF\nUHNUSU6JRWK=
MDA-MB-231 NFrIRXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF34SFNKSzVyPUS1MlEyQTlizszN MVXTRW5ITVJ?
ABC-1 M1LlVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGqzeI5KSzVyPUS2Mlg2OzhizszN NHHaRXdUSU6JRWK=
NCI-H446 NF3OeohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\nTWM2OD12OD61NFU5KM7:TR?= M4PFXHNCVkeHUh?=
MHH-PREB-1 MlrXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDlTWM2OD12OT62NFA4KM7:TR?= M1;UNnNCVkeHUh?=
DOHH-2 M4f4fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTR7Lk[2OVYh|ryP NEfh[YZUSU6JRWK=
GCT NXHlXFdiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlntTWM2OD12OT62PVc3KM7:TR?= NHH4bZRUSU6JRWK=

... Click to View More Cell Line Experimental Data

体内研究 17-AAG作用于携带3T3-src, B16或CT26移植瘤裸鼠,与Hsp90结合具有高亲和力,IC50为8-35 nM,而作用于正常组织时,IC50为200-600 nM。[1] 17-AAG按50 mg/kg左右剂量处理,引起AR, HER2, HER3, 和 Akt表达明显降低,降低达50%以上,这种作用存在剂量依赖性,结果导致雄激素依赖型 (CWR22)和非依赖型(CWR22R 和CWRSA6) 前列腺移植瘤生长受抑制,抑制率分别为67%, 80%和 68%。[2]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[1]
+ 展开

Hsp90结合实验:

纯化的Hsp90蛋白或过量表达HER-2的癌细胞(BT474, N87, SKOV3 和 SKBR3) 裂解物或BT474乳腺癌细胞溶于溶解buffer(20 mM HEPES, pH 7.3, 1 mM EDTA, 5 mM MgCl2, 100 mM KCl) ,与不同浓度17-AAG在4oC下温育30分钟,然后和生物素-GM链接的BioMag链霉亲和素磁珠在4oC下温育1小时。试管放置于磁架上,除去未结合的上清液。在溶解buffer中清洗三次磁珠,然后在SDS–PAGE 样本缓冲液中在95oC下加热5分钟。在SDS蛋白凝胶上进行样本分析,使用特点抗体进行Western Blotting。使用Bio-rad Fluor-S 多重图像测量Western Blot条带,计算抑制Hsp90与生物素-GM结合的百分数。测定IC50。
细胞实验:[1]
+ 展开
  • Cell lines: BT474, SKBR3, N87, SKOV3, MCF7, MDA468, Hs578T, Hs578Bst, A549, HT29, U87, SKMG3, HT1080, RPTEC, NDF, HMVEC, HMEC, HUVEC, 和 PBMC
  • Concentrations: 溶于DMSO, 终浓度为10 μM 左右
  • Incubation Time: 5天
  • Method: 细胞按每孔2000个接种在96孔板上,终培养体积为100 μL,培养24小时, 然后加入浓度不断增高的17-AAG,温育5天。使用 Celltiter 96 AQueous 非放射性细胞增殖检测试剂盒测定存活细胞数。测定IC50。
    (Only for Reference)
动物实验:[2]
+ 展开
  • Animal Models: 皮下注射雄激素依赖性CWR22移植瘤的雄性 nu/nu 无胸腺小鼠, 皮下注射雄激素非依赖性的CWR22R和CWRSA6移植瘤的雌性nu/nu 无胸腺小鼠。
  • Formulation: 溶于DMSO, 对照组用蛋磷脂(EPL)稀释
  • Dosages: 50 mg/kg 左右
  • Administration: 腹膜注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 100 mg/mL (170.73 mM)
Ethanol 5 mg/mL (8.53 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5%DMSO+corn oil
10mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 585.69
化学式

C31H43N3O8

CAS号 75747-14-7
稳定性 powder
in solvent
别名 CP127374,NSC-330507, KOS 953

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00577889 Completed Adenocarcinoma of the Pancreas|Recurrent Pancreatic Cancer|Stage IV Pancreatic Cancer National Cancer Institute (NCI) March 2008 Phase 2
NCT00546780 Completed Multiple Myeloma Bristol-Myers Squibb February 2008 Phase 3
NCT00093496 Completed Primary Peritoneal Cavity Cancer|Recurrent Ovarian Epithelial Cancer|Stage III Ovarian Epithelial Cancer|Stage IV Ovarian Epithelial Cancer National Cancer Institute (NCI) October 2007 Phase 2
NCT00514371 Completed Multiple Myeloma Bristol-Myers Squibb August 2007 Phase 2|Phase 3
NCT00779428 Completed Advanced Malignancies Bristol-Myers Squibb July 2006 Phase 2
NCT00354185 Terminated Adult Nasal Type Extranodal NK/T-cell Lymphoma|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Intraocular Lymphoma|Nodal Marginal Zone B-cell Lymphoma|Post-transplant Lymphoproliferative Disorder|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Hodgkin Lymphoma|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Adult T-cell Leukemia/Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Small Intestine Lymphoma|Splenic Marginal Zone Lymphoma|Stage III Adult Burkitt Lymphoma|Stage III Adult Diffuse Large Cell Lymphoma|Stage III Adult Diffuse Mixed Cell Lymphoma|Stage III Adult Diffuse Small Cleaved Cell Lymphoma|Stage III Adult Hodgkin Lymphoma|Stage III Adult Immunoblastic Large Cell Lymphoma|Stage III Adult Lymphoblastic Lymphoma|Stage III Adult T-cell Leukemia/Lymphoma|Stage III Cutaneous T-cell Non-Hodgkin Lymphoma|Stage III Grade 1 Follicular Lymphoma|Stage III Grade 2 Follicular Lymphoma|Stage III Grade 3 Follicular Lymphoma|Stage III Mantle Cell Lymphoma|Stage III Marginal Zone Lymphoma|Stage III Mycosis Fungoides/Sezary Syndrome|Stage III Small Lymphocytic Lymphoma|Stage IV Adult Burkitt Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma|Stage IV Adult Diffuse Mixed Cell Lymphoma|Stage IV Adult Diffuse Small Cleaved Cell Lymphoma|Stage IV Adult Hodgkin Lymphoma|Stage IV Adult Immunoblastic Large Cell Lymphoma|Stage IV Adult Lymphoblastic Lymphoma|Stage IV Adult T-cell Leukemia/Lymphoma|Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma|Stage IV Grade 1 Follicular Lymphoma|Stage IV Grade 2 Follicular Lymphoma|Stage IV Grade 3 Follicular Lymphoma|Stage IV Mantle Cell Lymphoma|Stage IV Marginal Zone Lymphoma|Stage IV Mycosis Fungoides/Sezary Syndrome|Stage IV Small Lymphocytic Lymphoma|Unspecified Adult Solid Tumor Protocol Specific|Waldenström Macroglobulinemia National Cancer Institute (NCI) May 2006 Phase 1

技术支持

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操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    What kind of subtypes does this compound inhibit? HSP90α or HSP90β ?

  • 回答:

    17-AAG can inhibit both HSP90α and HSP90β, but it is unclear how much are they affected respectively. You should note that Hsp90 derived from tumor cells has a 100-fold higher binding affinity for 17-AAG than that from normal cells according to this paper. http://www.nature.com.ezp-prod1.hul.harvard.edu/nature/journal/v425/n6956/full/nature01913.html

HSP (e.g. HSP90) Signaling Pathway Map

HSP (e.g. HSP90) Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID