Tanespimycin (17-AAG)

目录号:S1141 别名: CP127374,NSC-330507, KOS 953

Tanespimycin (17-AAG) Chemical Structure

Molecular Weight(MW): 585.69

Tanespimycin (17-AAG)是一种有效的HSP90抑制剂,无细胞试验中IC50为5 nM,作用于来自肿瘤细胞的HSP90比作用于来自正常细胞HSP90结合亲和力高100倍。Phase 2。

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RMB 1597.01 现货
RMB 1221.85 现货
RMB 3016.43 现货
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产品安全说明书

HSP (e.g. HSP90)抑制剂选择性比较

生物活性

产品描述 Tanespimycin (17-AAG)是一种有效的HSP90抑制剂,无细胞试验中IC50为5 nM,作用于来自肿瘤细胞的HSP90比作用于来自正常细胞HSP90结合亲和力高100倍。Phase 2。
特性 17-AAG对正常细胞的毒性很小。
靶点
HSP90 [1]
(Cell-free assay)
5 nM
体外研究

17-AAG是格尔德霉素类似物, 但是与过量表达HER-2的癌细胞 (BT474, N87, SKOV3 和SKBR3)或BT474乳腺细胞衍生的Hsp90亲和力高100多倍,IC50为5-6 nM, 而作用于正常人类原代细胞时,IC50为400-943 nM, 因为肿瘤Hsp90 处于多伴复合体状态,具有高ATP酶活性,而正常细胞Hsp90 处于潜在未结合状态, 且直接与那些细胞中17-AAG毒性相关。[1]17-AAG 引起HER2, HER3, Akt,突变和野生型雄激素受体(AR)降解,导致前列腺细胞如LNCaP, LAPC-4, DU-145,和PC-3中RB依赖的 G1 期生长停顿,IC50为25-45 nM。[2]除了诱导改变野生型BCR-ABL的Ba/F3细胞凋亡, IC50为5.2 μM, 17-AAG还通过诱导野生型和突变型 BCR-ABL蛋白降解,而诱导改变抗 Imatinib Mesylate的 T315I和 E255K BCR-ABL突变型细胞生长,IC50分别为2.3 μM 和 1.0 μM。[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A549 MnL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1znfWlEPTB;MD6wNFA{ODNizszN NU\GcHdrW0GQR1XS
IST-MEL1 NH\l[5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTBwMECwOFA4KM7:TR?= NH7oOI5USU6JRWK=
NCI-SNU-1 NUTmT3NVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;RbGdKSzVyPUCuNFAzODdizszN M2rDdnNCVkeHUh?=
FADU M17rUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwMECyNFkh|ryP M1TSR3NCVkeHUh?=
C32 NEniVJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlO2TWM2OD1yLkCwN|A1KM7:TR?= MmnWV2FPT0WU
D-566MG M1\NbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHFTWM2OD1yLkCwN|kh|ryP NG\xTWJUSU6JRWK=
LXF-289 M3fYRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zqTWlEPTB;MD6wNFQyQSEQvF2= NXTEcYc{W0GQR1XS
HGC-27 NXroTZV4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTmTnZKUUN3ME2wMlAxPTFizszN NGHOWXNUSU6JRWK=
RPMI-7951 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwMEC3NVch|ryP NEfPT4RUSU6JRWK=
HSC-3 Ml7nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTBwMEC5Nlkh|ryP MXrTRW5ITVJ?
MIA-PaCa-2 NFflRpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{njOWlEPTB;MD6wNVAxQSEQvF2= NVXs[JZRW0GQR1XS
KS-1 MmrLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLxTWM2OD1yLkCxN|U2KM7:TR?= MULTRW5ITVJ?
CAL-51 MmXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrRVZduUUN3ME2wMlAyPDB3IN88US=> M2izWnNCVkeHUh?=
MDA-MB-361 MoiyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDkTWM2OD1yLkCxOFk2KM7:TR?= NInBemdUSU6JRWK=
TI-73 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;lWmlEPTB;MD6wNVc6PiEQvF2= M4jVTHNCVkeHUh?=
AGS M1n6XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vDW2lEPTB;MD6wNVk{QCEQvF2= NIiweFhUSU6JRWK=
NCI-H460 NHnH[2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrOXGdKSzVyPUCuNFE6PzRizszN M4XLeHNCVkeHUh?=
A204 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjD[|lKSzVyPUCuNFIzPDlizszN MlfHV2FPT0WU
CHL-1 NVXKd3V3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;hdY5KSzVyPUCuNFIzPTFizszN MnvPV2FPT0WU
DU-4475 M1vJc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml32TWM2OD1yLkCyNlYyKM7:TR?= NYK0UGdWW0GQR1XS
CGTH-W-1 MofaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTBwMEKzOFkh|ryP Mmq1V2FPT0WU
HCC2218 NFLOfpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1X6[GlEPTB;MD6wNlQ6PCEQvF2= NFy2cHdUSU6JRWK=
A2780 NXfQZWlWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnUN3h3UUN3ME2wMlAzPTNzIN88US=> M{jPenNCVkeHUh?=
NCI-H720 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DOWGlEPTB;MD6wNlU1PiEQvF2= M1;ScHNCVkeHUh?=
NCI-N87 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXFTWM2OD1yLkCyOVk{KM7:TR?= Mni0V2FPT0WU
CHP-212 M1H0XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjV[4JRUUN3ME2wMlAzPjJ6IN88US=> MYrTRW5ITVJ?
NCI-H23 MnqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPzXHZTUUN3ME2wMlAzPjZ3IN88US=> MYjTRW5ITVJ?
D-263MG NETURnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwMEK3PFYh|ryP MYLTRW5ITVJ?
ME-180 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfYTWM2OD1yLkCyPFkyKM7:TR?= NGjCOmVUSU6JRWK=
SW982 M2jqT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHw[ZQ6UUN3ME2wMlAzQTl7IN88US=> MYrTRW5ITVJ?
OE19 M4XIfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjvXYhTUUN3ME2wMlA{ODd5IN88US=> M4q1enNCVkeHUh?=
SK-LU-1 NHX1eohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvYVppmUUN3ME2wMlA{ODh{IN88US=> NH7vXWVUSU6JRWK=
H4 NInvXmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1v0O2lEPTB;MD6wN|A6KM7:TR?= NFK0fpJUSU6JRWK=
HT-144 NX25UZczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnT2TWM2OD1yLkCzNFk{KM7:TR?= MXPTRW5ITVJ?
SK-UT-1 M1O2cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkO5TWM2OD1yLkCzNVc5KM7:TR?= NVP1dFdHW0GQR1XS
D-336MG MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwMEOzNFkh|ryP MWLTRW5ITVJ?
MDA-MB-175-VII M4fpTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVn4W4RSUUN3ME2wMlA{OzV2IN88US=> Mn\tV2FPT0WU
GAMG MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nXW2lEPTB;MD6wN|Q{PSEQvF2= MWjTRW5ITVJ?
CP50-MEL-B NV[3SGI3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrBNlA2UUN3ME2wMlA{PDVizszN NFXGOnFUSU6JRWK=
OVCAR-5 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7GPXBXUUN3ME2wMlA{PDhizszN NWnOc206W0GQR1XS
SK-MES-1 MkDiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\ETWM2OD1yLkCzOlA3KM7:TR?= NYDVOpJsW0GQR1XS
VM-CUB-1 NID1bZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3OcXlKSzVyPUCuNFM3PTdizszN M3;2RnNCVkeHUh?=
WM-115 M{Tzdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwMEO3OlIh|ryP NILPbnpUSU6JRWK=
DSH1 MoTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPzfHBZUUN3ME2wMlA{QDB5IN88US=> M33UZXNCVkeHUh?=
Becker MlrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTBwMEO4PFUh|ryP M1PBcHNCVkeHUh?=
SW962 MoDOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4Xz[2lEPTB;MD6wN|k1PSEQvF2= M1LFWHNCVkeHUh?=
TYK-nu Mn21S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHDW2J6UUN3ME2wMlA{QTh3IN88US=> MVLTRW5ITVJ?
HO-1-N-1 NYHOe5dLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fsWGlEPTB;MD6wOFAzOSEQvF2= M1W5dnNCVkeHUh?=
T98G M4DIdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfQNIhKSzVyPUCuNFQyODNizszN MX;TRW5ITVJ?
ACN NHiwNGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWiyNYMyUUN3ME2wMlA1OTZ{IN88US=> M2LJfHNCVkeHUh?=
SW780 MofDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nzT2lEPTB;MD6wOFIxOyEQvF2= NGPXdnlUSU6JRWK=
Detroit562 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkj3TWM2OD1yLkC0NlM6KM7:TR?= M3u2bnNCVkeHUh?=
BB49-HNC MmDuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnqxTWM2OD1yLkC0NlQ{KM7:TR?= MnjNV2FPT0WU
HN M33EWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmC5TWM2OD1yLkC0NlczKM7:TR?= MUjTRW5ITVJ?
H9 MofxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTBwMESzO|Eh|ryP NHLFeIpUSU6JRWK=
VA-ES-BJ M{jPXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTBwMES0OFch|ryP MnHhV2FPT0WU
MEL-JUSO M{HFcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DabWlEPTB;MD6wOFQ4PSEQvF2= MlfHV2FPT0WU
BT-474 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mni5TWM2OD1yLkC0OUDPxE1? MX3TRW5ITVJ?
CaR-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTBwMES1OFkh|ryP MYTTRW5ITVJ?
PSN1 M4r0Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHjXo1MUUN3ME2wMlA1PjB|IN88US=> MXvTRW5ITVJ?
KYSE-510 NFHDeFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LTZmlEPTB;MD6wOFY1QSEQvF2= M1\uVnNCVkeHUh?=
KP-4 NYL3XGhxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zzZmlEPTB;MD6wOFc2OyEQvF2= MmPDV2FPT0WU
KYSE-410 M3Hvc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMES3O|Ih|ryP NGruPZFUSU6JRWK=
G-402 M2Di[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTBwMES3PFkh|ryP NV;tS45CW0GQR1XS
DOK NEnrdYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDIb|lKSzVyPUCuNFQ6ODJizszN MX;TRW5ITVJ?
COR-L88 M3n3VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PDeGlEPTB;MD6wOFkyOiEQvF2= MV;TRW5ITVJ?
SKG-IIIa M3zzemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fNVWlEPTB;MD6wOFk5PiEQvF2= NEjMZ2FUSU6JRWK=
AN3-CA MnPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTBwMEWg{txO MX;TRW5ITVJ?
SW48 M3;Ybmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTBwMEWwN|kh|ryP NETib|hUSU6JRWK=
YKG-1 M4LKZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnS4TWM2OD1yLkC1NFcyKM7:TR?= MWPTRW5ITVJ?
KYSE-150 NUmxXJR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTBwMEWyN|Uh|ryP NFPlXGpUSU6JRWK=
HuO-3N1 NVHTcXptT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUG2cGx2UUN3ME2wMlA2OjN5IN88US=> MYjTRW5ITVJ?
LB1047-RCC NEW3WnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPXZ5dNUUN3ME2wMlA2Ojl4IN88US=> NWHkdGdnW0GQR1XS
NCI-H2030 MoTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTBwMEW0NVQh|ryP MkS0V2FPT0WU
YH-13 MofsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojjTWM2OD1yLkC1O|IzKM7:TR?= NEfEXI1USU6JRWK=
5637 MmrrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLpTWM2OD1yLkC1O|Qh|ryP MWjTRW5ITVJ?
LOXIMVI NIXQW4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPse5JNUUN3ME2wMlA2QDd{IN88US=> MmryV2FPT0WU
GT3TKB Mn7YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIOwV5BKSzVyPUCuNFU6PDJizszN M4PjSHNCVkeHUh?=
TCCSUP NEjD[GlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PBe2lEPTB;MD6wOVk3PCEQvF2= NYHpPYJmW0GQR1XS
EPLC-272H NVe3fINXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTBwME[yNFUh|ryP M4n2cXNCVkeHUh?=
LU-99A MlTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nyTGlEPTB;MD6wOlI{PyEQvF2= NUn2[np6W0GQR1XS
NCI-H1755 M37zbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\tbJVKSzVyPUCuNFY{PDFizszN MnnBV2FPT0WU
KM12 MmWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrzfnFPUUN3ME2wMlA3OzR6IN88US=> NGPGSoNUSU6JRWK=
SF295 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnZS5ByUUN3ME2wMlA3PDV{IN88US=> NIr2WZBUSU6JRWK=
MZ2-MEL NVvKcXpVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LFdmlEPTB;MD6wOlU2OyEQvF2= M2LtXXNCVkeHUh?=
HEC-1 NXPD[GhDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLZWWdKSzVyPUCuNFY2QDhizszN MkLQV2FPT0WU
SW684 M4LZOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwME[1PVEh|ryP M{fTdnNCVkeHUh?=
SF539 NXPvbopRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknFTWM2OD1yLkC2OlgyKM7:TR?= NWPlOpVyW0GQR1XS
GMS-10 Mo\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTBwME[2PVkh|ryP NV3Wb4w4W0GQR1XS
MV-4-11 NVf1T2xGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXuTWM2OD1yLkC2PFA{KM7:TR?= MV\TRW5ITVJ?
HT-29 MkPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3kT|BKSzVyPUCuNFY6OTlizszN Ml3rV2FPT0WU
23132-87 NHv2eVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\6fWFKSzVyPUCuNFY6PSEQvF2= NGThR|hUSU6JRWK=
SW620 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPTTWM2OD1yLkC3NFI3KM7:TR?= NXK0b5NnW0GQR1XS
HCC1806 NYjMcJlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPVWohEUUN3ME2wMlA4OTNzIN88US=> M3ruOHNCVkeHUh?=
Hs-578-T NWG1TVN{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXvTWM2OD1yLkC3NlA5KM7:TR?= NW\uV45tW0GQR1XS
A2058 NFrQNmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrLTWM2OD1yLkC3NlI5KM7:TR?= MXvTRW5ITVJ?
MEL-HO MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXO1WWhZUUN3ME2wMlA4OjV3IN88US=> MlW2V2FPT0WU
HCC2998 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwMEezOFch|ryP M{n6ZnNCVkeHUh?=
HuO9 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWryU3dEUUN3ME2wMlA4PTh7IN88US=> NUPDUpNOW0GQR1XS
CAL-39 M{\qeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTqZ3hPUUN3ME2wMlA4PzZ4IN88US=> NIrifoNUSU6JRWK=
M14 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX[1e2lTUUN3ME2wMlA4QTF|IN88US=> MYXTRW5ITVJ?
BFTC-909 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYG0Xmt2UUN3ME2wMlA4QTZ7IN88US=> MWfTRW5ITVJ?
TE-11 MmHkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXf5bIRjUUN3ME2wMlA4QTl4IN88US=> NV7leYF3W0GQR1XS
TGBC1TKB NIrK[ndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;zeYhEUUN3ME2wMlA5ODR|IN88US=> NUnUOmRLW0GQR1XS
L-363 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWqybVhDUUN3ME2wMlA5OjB4IN88US=> MmHtV2FPT0WU
A431 Ml;kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwMEiyNUDPxE1? NITlTYZUSU6JRWK=
MKN45 NWH6[WY6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvzXG4zUUN3ME2wMlA5OjF7IN88US=> Mnm3V2FPT0WU
HT-1080 Ml31S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nJbGlEPTB;MD6wPFQ{QSEQvF2= M1r2PHNCVkeHUh?=
OVCAR-8 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvxO4JKSzVyPUCuNFg3OjJizszN Mn7jV2FPT0WU
LCLC-97TM1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3T1fWlEPTB;MD6wPFczQCEQvF2= MojIV2FPT0WU
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SK-MEL-2 NVPnbGI{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzKWIpKSzVyPUCuNFkxPiEQvF2= Mo\3V2FPT0WU
TE-1 MkXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLQeIxQUUN3ME2wMlA6OjB2IN88US=> NIO5cVRUSU6JRWK=
KYSE-180 NUjEfIxmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;UTWM2OD1yLkC5NlYzKM7:TR?= NFLzXoZUSU6JRWK=
D-247MG M4HhW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jPSmlEPTB;MD6wPVQ2PSEQvF2= NELidFJUSU6JRWK=
8-MG-BA MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHQ[G0yUUN3ME2wMlA6PDd{IN88US=> NXrOVGE3W0GQR1XS
NCI-H1792 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYi3NotsUUN3ME2wMlA6PjF6IN88US=> M{LwOnNCVkeHUh?=
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NCI-H2122 NGK0T5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDtTWM2OD1yLkC5O|Q2KM7:TR?= NWnDVmZKW0GQR1XS
EFO-27 NF3qcXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnmTWM2OD1yLkC5PVk4KM7:TR?= M{jCdXNCVkeHUh?=
LB2241-RCC MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjsTWM2OD1yLkGwNFU1KM7:TR?= M1rqNXNCVkeHUh?=
SN12C NYn1dldXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2OzZWlEPTB;MD6xNFExPyEQvF2= NGq4eYpUSU6JRWK=
A498 NH;5fGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\jTWM2OD1yLkGwNVgh|ryP M13aS3NCVkeHUh?=
PANC-03-27 NIrCfnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXPWIVKUUN3ME2wMlExOjh4IN88US=> NHTIVFhUSU6JRWK=
NCI-H1581 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1K1RmlEPTB;MD6xNFI6KM7:TR?= Moq2V2FPT0WU
U-87-MG MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTBwMUCzNFch|ryP Mn\lV2FPT0WU
G-401 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLB[G5wUUN3ME2wMlExOzV|IN88US=> NHnvOlhUSU6JRWK=
SiHa MkHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHKTWM2OD1yLkGwOFg3KM7:TR?= NYLPNVVVW0GQR1XS
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BB65-RCC NIPN[3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIW5TlhKSzVyPUCuNVA2PTRizszN NWT3OFZCW0GQR1XS
NKM-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrxRoRKSzVyPUCuNVA3PjZizszN MV;TRW5ITVJ?
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TGBC11TKB MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7XTWM2OD1yLkGwPVA{KM7:TR?= M17uOHNCVkeHUh?=
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TE-8 NHnWNoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPNbFRzUUN3ME2wMlEyOjZ2IN88US=> MoC4V2FPT0WU
SK-MEL-28 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjxTItEUUN3ME2wMlEyOzJzIN88US=> MV\TRW5ITVJ?
SH-4 NGWxZ2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vTd2lEPTB;MD6xNVM2PiEQvF2= M1OyfnNCVkeHUh?=
KALS-1 MkTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFH2[YZKSzVyPUCuNVE{QTNizszN NULRdpd1W0GQR1XS
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OMC-1 M1SyXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTBwMUG3PVch|ryP NGe3W5ZUSU6JRWK=
BT-549 M1HWXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjZbVBKSzVyPUCuNVE4QTlizszN NFW4enhUSU6JRWK=
NCI-H28 Mn24S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXP6eZcxUUN3ME2wMlEyQDF5IN88US=> MoLKV2FPT0WU
RXF393 M4CxPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTBwMUG5PFIh|ryP MV;TRW5ITVJ?
COLO-829 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXe1c4hLUUN3ME2wMlEzODB3IN88US=> MY\TRW5ITVJ?
HMV-II Mkf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HEbGlEPTB;MD6xNlAzKM7:TR?= NF60cIpUSU6JRWK=
SW1990 Mn;PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTBwMUKxOVch|ryP M1fTRXNCVkeHUh?=
NCI-H1437 M2XDOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfBTWM2OD1yLkGyNVU4KM7:TR?= MoXkV2FPT0WU
SNB75 NWS3eI9JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\Jd5hvUUN3ME2wMlEzOTZ7IN88US=> MnfnV2FPT0WU
EW-3 Mk\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjqWWd{UUN3ME2wMlEzPjZzIN88US=> NXL2eJZkW0GQR1XS
SAS NWG5OZJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnmSZdKSzVyPUCuNVI3QSEQvF2= M3XR[XNCVkeHUh?=
NCI-H1666 M1PuN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fPZ2lEPTB;MD6xNlc4PCEQvF2= MXzTRW5ITVJ?
A375 NITtbm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkD3TWM2OD1yLkGyO|c5KM7:TR?= MnjDV2FPT0WU
CAMA-1 NV70ZYN2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwMUK5NlQh|ryP NF;YbFNUSU6JRWK=
HuP-T4 NHq4fWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwMUK5OFMh|ryP NUPVWZV[W0GQR1XS
NCI-H292 NGq4VW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTBwMUOxNUDPxE1? MXXTRW5ITVJ?
PC-14 NHO1d2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHOcmpKSzVyPUCuNVMzOTFizszN MkXGV2FPT0WU
BPH-1 NGLKWWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXNTWM2OD1yLkGzOFEh|ryP Mn;CV2FPT0WU
GAK MorhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYW4dYt{UUN3ME2wMlE{PTZ5IN88US=> NV\Ccm5FW0GQR1XS
VMRC-RCZ MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHCZ5lmUUN3ME2wMlE{PzZ{IN88US=> MWXTRW5ITVJ?
SK-MEL-24 NWW2NFBQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTBwMUO4O{DPxE1? M2HMTnNCVkeHUh?=
LB831-BLC MkHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjrPYQ6UUN3ME2wMlE{QDh|IN88US=> M3rIUnNCVkeHUh?=
NCI-H2452 MlTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfCTWM2OD1yLkGzPVU3KM7:TR?= MW\TRW5ITVJ?
RT-112 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofZTWM2OD1yLkG0NFM2KM7:TR?= M1:yOXNCVkeHUh?=
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MPP-89 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnsTWM2OD1yLkG0NVI2KM7:TR?= NULiXJFKW0GQR1XS
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GI-1 NHrVbZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vrOmlEPTB;MD6xOFU2QCEQvF2= Mm[zV2FPT0WU
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NCI-H2347 M1m3U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXyRY1[UUN3ME2wMlE1QDN7IN88US=> NIXYZXdUSU6JRWK=
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NCI-H1648 M4rveWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvRTWM2OD1yLkG1NlMzKM7:TR?= M17rR3NCVkeHUh?=
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ETK-1 M{jxN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTFTWM2OD1yLkG1PUDPxE1? MoryV2FPT0WU
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CAL-62 Ml7uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHH0RZRKSzVyPUCuNVYyPjlizszN MV7TRW5ITVJ?
HCC1937 M2j6bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwMU[yO|Uh|ryP NYDBV2ZbW0GQR1XS
NCI-H1299 M1rzdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHFTWM2OD1yLkG2Nlg2KM7:TR?= NYXOO5Z[W0GQR1XS
SW1088 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HodmlEPTB;MD6xOlQyOyEQvF2= NIH5TFVUSU6JRWK=
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OC-314 NGjOeHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3E[5pKSzVyPUCuNVY3QSEQvF2= NHzoPZRUSU6JRWK=
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COLO-824 MlfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzJfHpXUUN3ME2wMlE4Ojl2IN88US=> M37hcHNCVkeHUh?=
BB30-HNC Mo\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELMd4hKSzVyPUCuNVc{OyEQvF2= MYnTRW5ITVJ?
NCI-H2087 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPSTIVKSzVyPUCuNVc{PjhizszN NGC5XWZUSU6JRWK=
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KYSE-520 NH\sZXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XoemlEPTB;MD6xPFIh|ryP NFOxbYpUSU6JRWK=
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NCI-H1395 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\oVWFGUUN3ME2wMlE5Pjh{IN88US=> MYHTRW5ITVJ?
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KARPAS-45 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHuO29pUUN3ME2wMlM4QDZ{IN88US=> NU\hO2hnW0GQR1XS
NCI-H1793 MnnaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTBwM{i1NUDPxE1? MVLTRW5ITVJ?
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NCI-H2126 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjXUGpJUUN3ME2wMlU3QDF3IN88US=> M{PxTXNCVkeHUh?=
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DBTRG-05MG MmXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\tWmlEPTB;MD61PFA2OyEQvF2= MUPTRW5ITVJ?
MKN1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXtTm8xUUN3ME2wMlU5Pzh|IN88US=> NIXXT|BUSU6JRWK=
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OVCAR-3 MnnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoH3TWM2OD1yLkW5N|QyKM7:TR?= Mnf3V2FPT0WU
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CP66-MEL MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfUbVVbUUN3ME2wMlYxQTZ7IN88US=> MofWV2FPT0WU
NCI-H661 NHf6OoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrRdohVUUN3ME2wMlYyOTB2IN88US=> MlvoV2FPT0WU
UACC-893 M1rwOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHmeHI4UUN3ME2wMlY{PjhzIN88US=> MUPTRW5ITVJ?
JVM-3 MlzzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XwN2lEPTB;MD62N|gxPCEQvF2= NYCxWVZKW0GQR1XS
SF268 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2WxeWlEPTB;MD62OFM1QSEQvF2= NWPjWHJQW0GQR1XS
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RPMI-8226 MkHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\kW3J1UUN3ME2wMlY3OzJ|IN88US=> MlnsV2FPT0WU
MKN28 NXvpOGFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TrNmlEPTB;MD62OlYzPCEQvF2= MmnmV2FPT0WU
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BV-173 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrwSnFGUUN3ME2wMlY5Pjd7IN88US=> MnLVV2FPT0WU
NCI-H358 M3WxOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTLTWM2OD1yLk[4O|I3KM7:TR?= NWrYTYVUW0GQR1XS
NCI-H1651 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moq4TWM2OD1yLkeg{txO M4fk[HNCVkeHUh?=
MDA-MB-415 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\EdoN3UUN3ME2wMlcxQDJ7IN88US=> NXK5V3k3W0GQR1XS
8305C MnvIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVj0cYdiUUN3ME2wMlczPDl6IN88US=> Ml\iV2FPT0WU
EFM-19 M3vxT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\uSIpnUUN3ME2wMlc{PjdzIN88US=> Mk[wV2FPT0WU
RERF-LC-MS NFPMWmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlX2TWM2OD1yLke0OlE{KM7:TR?= MYnTRW5ITVJ?
A388 MoiwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XGUWlEPTB;MD63OlQ3PyEQvF2= NHLDZWVUSU6JRWK=
GI-ME-N M163[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnwXYxKSzVyPUCuO|czOzVizszN MoDYV2FPT0WU
IGR-1 NHTHSlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TOZ2lEPTB;MD63PVA1OyEQvF2= Mn;NV2FPT0WU
LNCaP-Clone-FGC M4HleWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHe3T3lKSzVyPUCuPFAxODRizszN NVzXVGE5W0GQR1XS
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C8166 M1;NTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDtNnd{UUN3ME21MlM3OzN7IN88US=> MnjHV2FPT0WU
LS-1034 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPFNFFmUUN3ME21MlQzOzB5IN88US=> NH\VcFlUSU6JRWK=
GR-ST NXrkdYQ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XVdWlEPTB;NT61NlIxOSEQvF2= NUHhXVlvW0GQR1XS
NCI-H1092 MofOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDPXGNnUUN3ME21MlczQDR|IN88US=> MoLuV2FPT0WU
647-V NGPwUnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjBVodsUUN3ME21Mlc1PzB4IN88US=> NIj6WXlUSU6JRWK=
EW-13 M3nZSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW[3ZpVOUUN3ME21Mlc3PjJ5IN88US=> M4\RUXNCVkeHUh?=
KGN MmT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{G4TGlEPTB;Nj6wPVkzOSEQvF2= M2HDUXNCVkeHUh?=
D-423MG MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\XU|JYUUN3ME22MlQxOjh2IN88US=> MWjTRW5ITVJ?
ECC10 NILkOXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;tZmlEPTB;Nz6xNFExOSEQvF2= MmDEV2FPT0WU
TE-5 Mom0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\uTWM2OD15LkSxNlk5KM7:TR?= NXrW[W5EW0GQR1XS
P12-ICHIKAWA MmfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUT2SHljUUN3ME23MlQ2PTJ|IN88US=> M4nXVXNCVkeHUh?=
NCI-H82 NYi3SpY4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfoPXJRUUN3ME23MlQ2PzBzIN88US=> M1fyWXNCVkeHUh?=
NCI-H1993 NFvwZYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXiz[nhvUUN3ME23Mlg{ODZ|IN88US=> MWPTRW5ITVJ?
RH-1 M33LPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF35XnZKSzVyPUeuPFUzPDRizszN MlvRV2FPT0WU
SW948 M1Xs[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjmOIJvUUN3ME23Mlk3ODR7IN88US=> MWfTRW5ITVJ?
CAL-33 NYKx[VhRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTdwOUm5N|gh|ryP M17wfXNCVkeHUh?=
U-266 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPWfXhKSzVyPUiuNVU4PzdizszN M{HHPHNCVkeHUh?=
CAL-72 NHvTPVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnrTWM2OD16LkKwN|Ih|ryP NGnxNWxUSU6JRWK=
SNU-423 NWC4XWJQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{n1bmlEPTB;OT6zOlY3PiEQvF2= MVrTRW5ITVJ?
KG-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTlwNUi0OVYh|ryP NIXRdJhUSU6JRWK=
HCC1395 MoDkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXyVJdCUUN3ME25MlkzOzV{IN88US=> NITubGtUSU6JRWK=
BE-13 NFm0TnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUH2b4g5UUN3ME2xNE45QDl{IN88US=> M2DicnNCVkeHUh?=
MKN7 NUfjWZBRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzBTWM2OD1zMD65O|Y2KM7:TR?= MXvTRW5ITVJ?
697 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnf3TWM2OD1zMT6xOFczKM7:TR?= MWTTRW5ITVJ?
LU-135 NUjUcJRzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTFzLkKzNFch|ryP MnjSV2FPT0WU
ES7 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGT2fJhKSzVyPUGxMlM{OTNizszN M3ThN3NCVkeHUh?=
SK-HEP-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPWTWM2OD1zMT63OlQ3KM7:TR?= Mm\0V2FPT0WU
BEN M3PYSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHyTWM2OD1zMT64OVEh|ryP M4q0PHNCVkeHUh?=
NCI-H1770 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkm0TWM2OD1zMj6xNlYh|ryP NV64VVFzW0GQR1XS
SW13 NHjLdWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjjTWM2OD1zMj6xOVQyKM7:TR?= NV34e25UW0GQR1XS
MZ1-PC MnnDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PIU2lEPTB;MUKuOVQ2OiEQvF2= MnnSV2FPT0WU
Mo-T Mn:xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\PPZZsUUN3ME2xNk44PDJzIN88US=> NWm4eWpnW0GQR1XS
HLE MkG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmP1TWM2OD1zMj64NlE2KM7:TR?= M2G1ZnNCVkeHUh?=
RCC10RGB NHrLcoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETWXXBKSzVyPUGzMlY4OSEQvF2= MmfXV2FPT0WU
COLO-320-HSR NFy1bJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PBNmlEPTB;MUOuO|M5OSEQvF2= NULJWFc6W0GQR1XS
BHT-101 NXG3[|VNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4j6WmlEPTB;MUOuPFM1PSEQvF2= M{G3[3NCVkeHUh?=
OCUB-M MmG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfSdHhKSzVyPUG0MlE3ODJizszN M37mO3NCVkeHUh?=
MEG-01 NG\UT|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XuXWlEPTB;MUSuN|cxQCEQvF2= NUTrb4c{W0GQR1XS
RS4-11 M{nUW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DGPWlEPTB;MUSuO|QzKM7:TR?= NEfJUGlUSU6JRWK=
MN-60 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HIWGlEPTB;MUSuO|g6PCEQvF2= NWPYXppnW0GQR1XS
NCI-H1304 M4Oybmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M123d2lEPTB;MUWuNFQzPSEQvF2= M{[xbXNCVkeHUh?=
Ramos-2G6-4C10 MmLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33RZmlEPTB;MUWuNFU5OSEQvF2= M4XoNnNCVkeHUh?=
NCI-H2342 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYG0UmdXUUN3ME2xOU4zODR2IN88US=> NILIfYtUSU6JRWK=
LAN-6 MoTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfaeIJtUUN3ME2xOU41PDF2IN88US=> MmPGV2FPT0WU
JVM-2 M3raT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXHTWM2OD1zNT61O|Q5KM7:TR?= NI\q[pRUSU6JRWK=
P30-OHK NGnvfVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4ftZmlEPTB;MU[uNFYyPCEQvF2= M{PaSnNCVkeHUh?=
C-33-A MkXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTF4Lk[yNVQh|ryP MVvTRW5ITVJ?
RPMI-8866 M1PrfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTF4Lki0PVYh|ryP MlPLV2FPT0WU
NCI-H630 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvFTWM2OD1zNj64OVM4KM7:TR?= NFmxe5pUSU6JRWK=
KYSE-140 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3uV4xKSzVyPUG3MlIxOjhizszN MnmxV2FPT0WU
T84 M3\jd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLzTWM2OD1zOD64Olk2KM7:TR?= MWTTRW5ITVJ?
KU-19-19 M{PYfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HzZmlEPTB;MUiuPVYxQCEQvF2= NGL2PIVUSU6JRWK=
BALL-1 M2HTeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTF7LkOzPVkh|ryP NXrNPYh2W0GQR1XS
Calu-6 NVrYTHd7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7HTWM2OD1zOT60PVIh|ryP NYDk[XI{W0GQR1XS
EGI-1 M1;pOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETYdIRKSzVyPUG5MlU6QCEQvF2= MYTTRW5ITVJ?
MFH-ino NGDJeYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTF7Lke0OVQh|ryP M1fvO3NCVkeHUh?=
GB-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPTNYE3UUN3ME2yNE4{PTN3IN88US=> M1[3cXNCVkeHUh?=
NCI-H1693 NH[3XXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXpTWM2OD1{MD62OVA2KM7:TR?= NV\u[GtOW0GQR1XS
SW1116 NEfyWIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfkbI5PUUN3ME2yNE46OzZ{IN88US=> M4TieXNCVkeHUh?=
H-EMC-SS NEHVUphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkC2TWM2OD1{Mj6wOFUh|ryP NHXPUlBUSU6JRWK=
D-502MG NHzicoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTJ{LkiyOlEh|ryP MkPsV2FPT0WU
IA-LM NYHVVGZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTETWM2OD1{Mz6yOFk{KM7:TR?= NXjLdWcxW0GQR1XS
SW1463 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTJ|Lke5JO69VQ>? MWLTRW5ITVJ?
JAR NX71OWpNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTJ2LkOyPVMh|ryP MVPTRW5ITVJ?
HT MnjiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHmxZodKSzVyPUK0MlQ4PTNizszN MYLTRW5ITVJ?
LCLC-103H MlvtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;wTWM2OD1{ND64OFQ6KM7:TR?= NVT2e|F1W0GQR1XS
SNU-449 NInzenRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnCTWM2OD1{ND64O|QyKM7:TR?= MnTXV2FPT0WU
KE-37 NHzRVWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTJ3LkC5Nlgh|ryP M{DEe3NCVkeHUh?=
NCI-H1623 Mom5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTTZ5BUUUN3ME2yO{4yOzB|IN88US=> NVLOO3NnW0GQR1XS
MOLT-13 NXrGT|dGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnmT49KSzVyPUK3MlM2OTZizszN NIL4SY5USU6JRWK=
COLO-741 NFTlPW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTNzLkOzN|Mh|ryP MVrTRW5ITVJ?
NB6 NV:xXJhCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDQTXpKSzVyPUOyMlI5PzZizszN NIe0NpdUSU6JRWK=
MOLT-16 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPtOYdKSzVyPUOzMlAxPTVizszN M1X6eXNCVkeHUh?=
IST-MES1 NF3tRWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjjdIVOUUN3ME2zOE4xPTRzIN88US=> MkP4V2FPT0WU
A4-Fuk MoPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTN3LkC2OkDPxE1? NF;GRXNUSU6JRWK=
CAL-85-1 NF\zWIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HOWWlEPTB;M{WuNlgyPyEQvF2= NVTaN2UyW0GQR1XS
CCRF-CEM Mnn1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInYRZdKSzVyPUO3MlE2OzZizszN M3OyNXNCVkeHUh?=
HAL-01 NWTEb2xNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzYV3ZyUUN3ME2zPE41QDh7IN88US=> MlfhV2FPT0WU
HEL M4DRV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjONYxKSzVyPUSzMlM1ODlizszN MnSxV2FPT0WU
EW-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1f6N2lEPTB;NEOuOFc3QCEQvF2= MnjaV2FPT0WU
MDA-MB-231 NIi5NndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nqOGlEPTB;NEWuNVE6QSEQvF2= NVn1UpN1W0GQR1XS
ABC-1 NWH2TFVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVe3eI8xUUN3ME20Ok45PTN6IN88US=> Mm\3V2FPT0WU
NCI-H446 Mo\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTR6LkWwOVgh|ryP Mn3sV2FPT0WU
MHH-PREB-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPwcFlKSzVyPUS5MlYxODdizszN MX;TRW5ITVJ?
DOHH-2 Mk\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTR7Lk[2OVYh|ryP MkTrV2FPT0WU
GCT M4ezT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fZWmlEPTB;NEmuOlk4PiEQvF2= Mn3YV2FPT0WU

... Click to View More Cell Line Experimental Data

体内研究 17-AAG作用于携带3T3-src, B16或CT26移植瘤裸鼠,与Hsp90结合具有高亲和力,IC50为8-35 nM,而作用于正常组织时,IC50为200-600 nM。[1] 17-AAG按50 mg/kg左右剂量处理,引起AR, HER2, HER3, 和 Akt表达明显降低,降低达50%以上,这种作用存在剂量依赖性,结果导致雄激素依赖型 (CWR22)和非依赖型(CWR22R 和CWRSA6) 前列腺移植瘤生长受抑制,抑制率分别为67%, 80%和 68%。[2]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[1]
+ 展开

Hsp90结合实验:

纯化的Hsp90蛋白或过量表达HER-2的癌细胞(BT474, N87, SKOV3 和 SKBR3) 裂解物或BT474乳腺癌细胞溶于溶解buffer(20 mM HEPES, pH 7.3, 1 mM EDTA, 5 mM MgCl2, 100 mM KCl) ,与不同浓度17-AAG在4oC下温育30分钟,然后和生物素-GM链接的BioMag链霉亲和素磁珠在4oC下温育1小时。试管放置于磁架上,除去未结合的上清液。在溶解buffer中清洗三次磁珠,然后在SDS–PAGE 样本缓冲液中在95oC下加热5分钟。在SDS蛋白凝胶上进行样本分析,使用特点抗体进行Western Blotting。使用Bio-rad Fluor-S 多重图像测量Western Blot条带,计算抑制Hsp90与生物素-GM结合的百分数。测定IC50。
细胞实验:[1]
+ 展开
  • Cell lines: BT474, SKBR3, N87, SKOV3, MCF7, MDA468, Hs578T, Hs578Bst, A549, HT29, U87, SKMG3, HT1080, RPTEC, NDF, HMVEC, HMEC, HUVEC, 和 PBMC
  • Concentrations: 溶于DMSO, 终浓度为10 μM 左右
  • Incubation Time: 5天
  • Method: 细胞按每孔2000个接种在96孔板上,终培养体积为100 μL,培养24小时, 然后加入浓度不断增高的17-AAG,温育5天。使用 Celltiter 96 AQueous 非放射性细胞增殖检测试剂盒测定存活细胞数。测定IC50。
    (Only for Reference)
动物实验:[2]
+ 展开
  • Animal Models: 皮下注射雄激素依赖性CWR22移植瘤的雄性 nu/nu 无胸腺小鼠, 皮下注射雄激素非依赖性的CWR22R和CWRSA6移植瘤的雌性nu/nu 无胸腺小鼠。
  • Formulation: 溶于DMSO, 对照组用蛋磷脂(EPL)稀释
  • Dosages: 50 mg/kg 左右
  • Administration: 腹膜注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 100 mg/mL (170.73 mM)
Ethanol 5 mg/mL (8.53 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5%DMSO+corn oil
10mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 585.69
化学式

C31H43N3O8

CAS号 75747-14-7
稳定性 powder
in solvent
别名 CP127374,NSC-330507, KOS 953

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00577889 Completed Adenocarcinoma of the Pancreas|Recurrent Pancreatic Cancer|Stage IV Pancreatic Cancer National Cancer Institute (NCI) March 2008 Phase 2
NCT00577889 Completed Adenocarcinoma of the Pancreas|Recurrent Pancreatic Cancer|Stage IV Pancreatic Cancer National Cancer Institute (NCI) March 2008 Phase 2
NCT00546780 Completed Multiple Myeloma Bristol-Myers Squibb February 2008 Phase 3
NCT00546780 Completed Multiple Myeloma Bristol-Myers Squibb February 2008 Phase 3
NCT00093496 Completed Primary Peritoneal Cavity Cancer|Recurrent Ovarian Epithelial Cancer|Stage III Ovarian Epithelial Cancer|Stage IV Ovarian Epithelial Cancer National Cancer Institute (NCI) October 2007 Phase 2
NCT00093496 Completed Primary Peritoneal Cavity Cancer|Recurrent Ovarian Epithelial Cancer|Stage III Ovarian Epithelial Cancer|Stage IV Ovarian Epithelial Cancer National Cancer Institute (NCI) October 2007 Phase 2

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操作手册

如果有其他问题,请给我们留言。

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常见问题及建议解决方法

  • 问题 1:

    What kind of subtypes does this compound inhibit? HSP90α or HSP90β ?

  • 回答:

    17-AAG can inhibit both HSP90α and HSP90β, but it is unclear how much are they affected respectively. You should note that Hsp90 derived from tumor cells has a 100-fold higher binding affinity for 17-AAG than that from normal cells according to this paper. http://www.nature.com.ezp-prod1.hul.harvard.edu/nature/journal/v425/n6956/full/nature01913.html

HSP (e.g. HSP90) Signaling Pathway Map

HSP (e.g. HSP90) Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID