Tanespimycin (17-AAG)

目录号:S1141 别名: CP127374,NSC-330507, KOS 953

Tanespimycin (17-AAG) Chemical Structure

Molecular Weight(MW): 585.69

Tanespimycin (17-AAG)是一种有效的HSP90抑制剂,无细胞试验中IC50为5 nM,作用于来自肿瘤细胞的HSP90比作用于来自正常细胞HSP90结合亲和力高100倍。Phase 2。

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RMB 1597.01 现货
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RMB 3016.43 现货
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客户使用Selleck该产品发表文献20篇:

客户使用该产品的9个实验数据:

  • (A) Cell lines were seeded in 96-well plates and treated with 10 nM of 17-AAG for 72 h. Cell survival was analyzed using CellTiter-Glo. Both parental H3122 cells (red bar) and H3122 CR cells (blue bar) show sensitivity to 17-AAG. (B) Suppression of ALK signaling by 17-AAG in resistant H3122 CR cells. H3122 parental and resistant cells were exposed to increasing concentrations of 17-AAG for 6 h.

    PNAS, 2011, 108: 7535-40. Tanespimycin (17-AAG) purchased from Selleck.

    (A) Treatment of DIPG cells with an HSP90 inhibitor, 17-AAG, resulted in decreased invasion toward SVZ hNPC CM at high doses. (B) Cell viability of DIPG cells treated with increasing doses of 17-AAG, by the CellTiter-Glo assay.

    Cell, 2017, 170(5):845-859.e19. Tanespimycin (17-AAG) purchased from Selleck.

  • SKBR3 cells were treated with FW-04-806 at 10, 20, 40 uM for 24 h; 17AAG was used as a positive control at 1 and 2 uM. Hsp70, Hsp90, and Cdc37 protein level were analyzed with western blotting using relevant antibodies.

    Mol Cancer 2014 13, 150. Tanespimycin (17-AAG) purchased from Selleck.

    Western blot analysis of immunoprecipitated Hsp90/BIP complexes in MOLT-4 (T-ALL) and RS4;11 (B-ALL) treated for 22 h with CX-4945 (5 μM) and bortezomib (2.5 nM) either alone or in combination. 500 μg of protein lysates were immunoprecipitated with anti-Hsp90 antibody. Relative Induction values (Rel.Ind.) were obtained by normalizing to Hsp90 bands density. 17-AAG: tanespimycin.

    Oncotarget, 2015, 51: S659-S660. Tanespimycin (17-AAG) purchased from Selleck.

  • Co-IP analyses of direct interaction between HSP90 and HIF-1α in 17-AAG (5 μM)-treated HSCs using antibodies against HSP90, HIF-1α or IgG (n = 2).

    Br J Pharmacol, 2017, 174(5):409-423. Tanespimycin (17-AAG) purchased from Selleck.

    Treatment with an Hsp90 inhibitor results in a dose-dependent decrease in complex IV activity. A, because Hsp90 levels were reduced by 80%, in PINK1 null dopaminergic neuronal cells, the effects of specific inhibition of Hsp90 using 17-AAG were analyzed in wild-type neuronal cells. Both complex IV activity and Hsp60 levels were decreased significantly in 17-AAG-treated cells in a dose-dependent manner. B, in contrast, 17-AAG treatment did not affect expression of Hsp90 and LRPPRC.

    J Biol Chem 2012 287, 44109-20. Tanespimycin (17-AAG) purchased from Selleck.

  • UPR modulators destabilize mSmoM2. NIH 3T3 cells expressing mSmoM2 protein were treated with HSP90 inhibitors 17-AAG (50 uM and 100 uM) and SNX-2112 (25 uM and 50 uM) and the proteasome inhibitor bortezomib (25 uM and 50 uM) for 4 h prior to lysis. DMSO was the vehicle control. Western blotting of whole-cell lysates revealed mSmoM2 protein to be destabilized in response to HSP-90 inhibitors but not in response to bortezomib. Tubulin was the loading control. CHOP results indicate ER stress.

    Mol Cell Biol 2013 33(12), 2375-87. Tanespimycin (17-AAG) purchased from Selleck.

    Hsp90 is up-regulated during aging. Whole-cell extracts were prepared from young (PD 20) and old (PD 40) HFSN1 cells. c HFSN1 cells (PD 40) were treated with different concentration of the Hsp90 inhibitor (17-AAG) and then re-incubated for 24 h. Whole-cell extracts were prepared and analyzed by western blot using the indicated antibodies.

    Age 2013 35, 549-62. Tanespimycin (17-AAG) purchased from Selleck.

  • Four types of the colon cancer cells with indicated K-Ras phenotype were incubated with indicated concentration of 17-AAG for 24 h, which were then analyzed for protein expression by WB.

    Oncotarget 2014 5, 4269-82. Tanespimycin (17-AAG) purchased from Selleck.

产品安全说明书

HSP (e.g. HSP90)抑制剂选择性比较

生物活性

产品描述 Tanespimycin (17-AAG)是一种有效的HSP90抑制剂,无细胞试验中IC50为5 nM,作用于来自肿瘤细胞的HSP90比作用于来自正常细胞HSP90结合亲和力高100倍。Phase 2。
特性 17-AAG对正常细胞的毒性很小。
靶点
HSP90 [1]
(Cell-free assay)
5 nM
体外研究

17-AAG是格尔德霉素类似物, 但是与过量表达HER-2的癌细胞 (BT474, N87, SKOV3 和SKBR3)或BT474乳腺细胞衍生的Hsp90亲和力高100多倍,IC50为5-6 nM, 而作用于正常人类原代细胞时,IC50为400-943 nM, 因为肿瘤Hsp90 处于多伴复合体状态,具有高ATP酶活性,而正常细胞Hsp90 处于潜在未结合状态, 且直接与那些细胞中17-AAG毒性相关。[1]17-AAG 引起HER2, HER3, Akt,突变和野生型雄激素受体(AR)降解,导致前列腺细胞如LNCaP, LAPC-4, DU-145,和PC-3中RB依赖的 G1 期生长停顿,IC50为25-45 nM。[2]除了诱导改变野生型BCR-ABL的Ba/F3细胞凋亡, IC50为5.2 μM, 17-AAG还通过诱导野生型和突变型 BCR-ABL蛋白降解,而诱导改变抗 Imatinib Mesylate的 T315I和 E255K BCR-ABL突变型细胞生长,IC50分别为2.3 μM 和 1.0 μM。[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A549 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jXeWlEPTB;MD6wNFA{ODNizszN NEDjcVlUSU6JRWK=
IST-MEL1 NUTCRZo{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvRNnZwUUN3ME2wMlAxODRyNzFOwG0> NIXVeG1USU6JRWK=
NCI-SNU-1 MlfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3ITWM2OD1yLkCwNlA4KM7:TR?= MkW5V2FPT0WU
FADU NVPwe5hUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LD[WlEPTB;MD6wNFIxQSEQvF2= NEDiO2lUSU6JRWK=
C32 NELvb45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TPUGlEPTB;MD6wNFMxPCEQvF2= MmfqV2FPT0WU
D-566MG MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3uNndCUUN3ME2wMlAxOzlizszN NFzuOotUSU6JRWK=
LXF-289 Mk\3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYqx[5prUUN3ME2wMlAxPDF7IN88US=> NFvIUIFUSU6JRWK=
HGC-27 NHHBTmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTBwMEC1NUDPxE1? Mkj4V2FPT0WU
RPMI-7951 NGPpNHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXG4[3hlUUN3ME2wMlAxPzF5IN88US=> MYDTRW5ITVJ?
HSC-3 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwMEC5Nlkh|ryP NHHieZlUSU6JRWK=
MIA-PaCa-2 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moi5TWM2OD1yLkCxNFA6KM7:TR?= MnTCV2FPT0WU
KS-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PQcGlEPTB;MD6wNVM2PSEQvF2= M{PLbHNCVkeHUh?=
CAL-51 NGCyOYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nkZ2lEPTB;MD6wNVQxPSEQvF2= NVz3VZNTW0GQR1XS
MDA-MB-361 MnGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTBwMEG0PVUh|ryP NWLSRmNMW0GQR1XS
TI-73 NV62fVMzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLKeFA{UUN3ME2wMlAyPzl4IN88US=> MVnTRW5ITVJ?
AGS NFr5dHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\KVGRKSzVyPUCuNFE6OzhizszN NXrJUpgyW0GQR1XS
NCI-H460 M3fDXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3f4[2lEPTB;MD6wNVk4PCEQvF2= MXrTRW5ITVJ?
A204 MlvZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTBwMEKyOFkh|ryP NUXyRYJOW0GQR1XS
CHL-1 M3[wcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnq[W9KSzVyPUCuNFIzPTFizszN MnTOV2FPT0WU
DU-4475 NULpO4tNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPLTFFKSzVyPUCuNFIzPjFizszN Mn;6V2FPT0WU
CGTH-W-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwMEKzOFkh|ryP M1\yfXNCVkeHUh?=
HCC2218 NWjXZ5dwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\oUXlyUUN3ME2wMlAzPDl2IN88US=> NFPDRYFUSU6JRWK=
A2780 NIPrfnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwMEK1N|Eh|ryP MX;TRW5ITVJ?
NCI-H720 M{HLNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\r[mlEPTB;MD6wNlU1PiEQvF2= MkHBV2FPT0WU
NCI-N87 NULrZVJoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\0TWM2OD1yLkCyOVk{KM7:TR?= NFHEOnJUSU6JRWK=
CHP-212 M{G0V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HrNmlEPTB;MD6wNlYzQCEQvF2= NVq1N2J7W0GQR1XS
NCI-H23 NVzXclNMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVu5OpRQUUN3ME2wMlAzPjZ3IN88US=> MljiV2FPT0WU
D-263MG NX7vNYlJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTBwMEK3PFYh|ryP M1ntNnNCVkeHUh?=
ME-180 M3XPXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwMEK4PVEh|ryP MU\TRW5ITVJ?
SW982 NUnk[IJyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rFdmlEPTB;MD6wNlk6QSEQvF2= NWnOfGN[W0GQR1XS
OE19 M2juS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrSTWM2OD1yLkCzNFc4KM7:TR?= NIHNOlNUSU6JRWK=
SK-LU-1 MnrZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1f0XmlEPTB;MD6wN|A5OiEQvF2= MXXTRW5ITVJ?
H4 NWXE[2x6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPtTWM2OD1yLkCzNFkh|ryP MmruV2FPT0WU
HT-144 NYn5enhZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TTfGlEPTB;MD6wN|A6OyEQvF2= NXvzN4RkW0GQR1XS
SK-UT-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTBwMEOxO|gh|ryP NEeyS|hUSU6JRWK=
D-336MG NVnx[ZJyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHld5NGUUN3ME2wMlA{OzB7IN88US=> M1f5OnNCVkeHUh?=
MDA-MB-175-VII MmfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfpTWM2OD1yLkCzN|U1KM7:TR?= MkLrV2FPT0WU
GAMG MnLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XjNGlEPTB;MD6wN|Q{PSEQvF2= NWXVcI5zW0GQR1XS
CP50-MEL-B NV\l[pg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwMEO0OUDPxE1? M3K2[nNCVkeHUh?=
OVCAR-5 NWXq[m8{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHtTWM2OD1yLkCzOFgh|ryP M1Lae3NCVkeHUh?=
SK-MES-1 M2fkN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTYW|hpUUN3ME2wMlA{PjB4IN88US=> M1\ZcXNCVkeHUh?=
VM-CUB-1 MmTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHrTWM2OD1yLkCzOlU4KM7:TR?= MWfTRW5ITVJ?
WM-115 NVXBfJNPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTBwMEO3OlIh|ryP NVe0SVVJW0GQR1XS
DSH1 MmPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DrV2lEPTB;MD6wN|gxPyEQvF2= NH3sOZRUSU6JRWK=
Becker NGezbJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jFeGlEPTB;MD6wN|g5PSEQvF2= M2DhcnNCVkeHUh?=
SW962 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwMEO5OFUh|ryP MV\TRW5ITVJ?
TYK-nu MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPmUJhKSzVyPUCuNFM6QDVizszN M2PCPXNCVkeHUh?=
HO-1-N-1 NVizUWsyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjlTWM2OD1yLkC0NFIyKM7:TR?= NYX5WlZ3W0GQR1XS
T98G NX;5XWdMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrVTWM2OD1yLkC0NVA{KM7:TR?= MXLTRW5ITVJ?
ACN NUf2Zo9GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DBSGlEPTB;MD6wOFE3OiEQvF2= MYPTRW5ITVJ?
SW780 NXr1[Ww1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHSOFI{UUN3ME2wMlA1OjB|IN88US=> MnHrV2FPT0WU
Detroit562 M2HhVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTOOFlKSzVyPUCuNFQzOzlizszN MXvTRW5ITVJ?
BB49-HNC NVrTW5RoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjzOHVKSzVyPUCuNFQzPDNizszN M{Lz[nNCVkeHUh?=
HN NV75S4VIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTBwMESyO|Ih|ryP MWHTRW5ITVJ?
H9 NWfTWZZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwMESzO|Eh|ryP Mnu3V2FPT0WU
VA-ES-BJ M2\6VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTBwMES0OFch|ryP MXvTRW5ITVJ?
MEL-JUSO Mn[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrFTWM2OD1yLkC0OFc2KM7:TR?= NHKzb4RUSU6JRWK=
BT-474 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwMES1JO69VQ>? NUfVS2tLW0GQR1XS
CaR-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPXd|VGUUN3ME2wMlA1PTR7IN88US=> MX7TRW5ITVJ?
PSN1 NWexTVdbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjuTWM2OD1yLkC0OlA{KM7:TR?= MY\TRW5ITVJ?
KYSE-510 M4LncWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\MTWM2OD1yLkC0OlQ6KM7:TR?= NVj5VlIyW0GQR1XS
KP-4 NWDMeG5jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTBwMES3OVMh|ryP NUj4PZI{W0GQR1XS
KYSE-410 M{XZSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjrTWM2OD1yLkC0O|czKM7:TR?= MWTTRW5ITVJ?
G-402 MlfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTBwMES3PFkh|ryP M1e5UnNCVkeHUh?=
DOK MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPVTWM2OD1yLkC0PVAzKM7:TR?= NIW1cYVUSU6JRWK=
COR-L88 NY\Ccpl3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLqc3pQUUN3ME2wMlA1QTF{IN88US=> NHjVXmtUSU6JRWK=
SKG-IIIa MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkmzTWM2OD1yLkC0PVg3KM7:TR?= MoPZV2FPT0WU
AN3-CA M4ixU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jUXGlEPTB;MD6wOUDPxE1? MYfTRW5ITVJ?
SW48 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzmXY9KSzVyPUCuNFUxOzlizszN M2PFNXNCVkeHUh?=
YKG-1 NFOzSHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknLTWM2OD1yLkC1NFcyKM7:TR?= M1m5TnNCVkeHUh?=
KYSE-150 NHjCdXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzB[VVKSzVyPUCuNFUzOzVizszN NXjDTXhDW0GQR1XS
HuO-3N1 M2\jdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV6yVHJjUUN3ME2wMlA2OjN5IN88US=> M1rBR3NCVkeHUh?=
LB1047-RCC NEnncVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTBwMEWyPVYh|ryP NYPReHM3W0GQR1XS
NCI-H2030 NWDMSFZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTBwMEW0NVQh|ryP NWXjO3NPW0GQR1XS
YH-13 NIHTfmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwMEW3NlIh|ryP NEL0[XVUSU6JRWK=
5637 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorXTWM2OD1yLkC1O|Qh|ryP MXjTRW5ITVJ?
LOXIMVI M3rxXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfqTWM2OD1yLkC1PFczKM7:TR?= MVrTRW5ITVJ?
GT3TKB M1TlXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjXcVFKSzVyPUCuNFU6PDJizszN NVXDXm1oW0GQR1XS
TCCSUP NV;oSIZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnwU2I3UUN3ME2wMlA2QTZ2IN88US=> NFjjSGtUSU6JRWK=
EPLC-272H NV7ZZ4ZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnNOot7UUN3ME2wMlA3OjB3IN88US=> M1;tO3NCVkeHUh?=
LU-99A MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvxVHBKSzVyPUCuNFYzOzdizszN NVXQV3NWW0GQR1XS
NCI-H1755 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljHTWM2OD1yLkC2N|QyKM7:TR?= MXHTRW5ITVJ?
KM12 NIK4[YNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTBwME[zOFgh|ryP MY\TRW5ITVJ?
SF295 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;IcohiUUN3ME2wMlA3PDV{IN88US=> NUPFTms3W0GQR1XS
MZ2-MEL NW\QSIxST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnTO3FSUUN3ME2wMlA3PTV|IN88US=> NFrLbHNUSU6JRWK=
HEC-1 M1nhdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIW2RZZKSzVyPUCuNFY2QDhizszN MUPTRW5ITVJ?
SW684 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7GR5pKSzVyPUCuNFY2QTFizszN NUDaSINQW0GQR1XS
SF539 MkHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUC1dHFqUUN3ME2wMlA3PjhzIN88US=> MX7TRW5ITVJ?
GMS-10 MmXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLY[pZKSzVyPUCuNFY3QTlizszN NFfSUYNUSU6JRWK=
MV-4-11 MnPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\oOmlEPTB;MD6wOlgxOyEQvF2= NWThVpdIW0GQR1XS
HT-29 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInzUVlKSzVyPUCuNFY6OTlizszN MVzTRW5ITVJ?
23132-87 NH;K[ZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFu5bJhKSzVyPUCuNFY6PSEQvF2= MmHBV2FPT0WU
SW620 M3PUc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjoTWM2OD1yLkC3NFI3KM7:TR?= MV7TRW5ITVJ?
HCC1806 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrQfo5KSzVyPUCuNFcyOzFizszN MWjTRW5ITVJ?
Hs-578-T M3S0Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorqTWM2OD1yLkC3NlA5KM7:TR?= NVLlO2FpW0GQR1XS
A2058 M1nlNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXLT2lKSzVyPUCuNFczOjhizszN NF24R4FUSU6JRWK=
MEL-HO M3yyfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTBwMEeyOVUh|ryP MljaV2FPT0WU
HCC2998 NITDdVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{O3fGlEPTB;MD6wO|M1PyEQvF2= M3O1NXNCVkeHUh?=
HuO9 NV7JSXdqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{K2[mlEPTB;MD6wO|U5QSEQvF2= MX3TRW5ITVJ?
CAL-39 M3f6d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfYTWM2OD1yLkC3O|Y3KM7:TR?= NVvH[HV5W0GQR1XS
M14 M3frR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEj2U2ZKSzVyPUCuNFc6OTNizszN MY\TRW5ITVJ?
BFTC-909 M3HyWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTBwMEe5Olkh|ryP NEHCT3FUSU6JRWK=
TE-11 MlO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3X2dmlEPTB;MD6wO|k6PiEQvF2= MmD6V2FPT0WU
TGBC1TKB MmHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLHTWM2OD1yLkC4NFQ{KM7:TR?= NVTCWXVDW0GQR1XS
L-363 M3z4N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoL4TWM2OD1yLkC4NlA3KM7:TR?= MkD5V2FPT0WU
A431 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml61TWM2OD1yLkC4NlEh|ryP MXPTRW5ITVJ?
MKN45 MmnsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDITWM2OD1yLkC4NlE6KM7:TR?= M4j4THNCVkeHUh?=
HT-1080 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDEcGxGUUN3ME2wMlA5PDN7IN88US=> NW\2OFBtW0GQR1XS
OVCAR-8 M123TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rDSGlEPTB;MD6wPFYzOiEQvF2= NVjEfZNSW0GQR1XS
LCLC-97TM1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fvU2lEPTB;MD6wPFczQCEQvF2= M3P0bnNCVkeHUh?=
M059J M2WyWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DD[WlEPTB;MD6wPVAzPyEQvF2= M{XC[HNCVkeHUh?=
SK-MEL-2 NV70bFZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPYfmRoUUN3ME2wMlA6ODZizszN NIrXcZVUSU6JRWK=
TE-1 M2DXfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nneWlEPTB;MD6wPVIxPCEQvF2= MUjTRW5ITVJ?
KYSE-180 Mmi3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTBwMEmyOlIh|ryP M{jod3NCVkeHUh?=
D-247MG M3;DUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTT[YpKSzVyPUCuNFk1PTVizszN M{LTNHNCVkeHUh?=
8-MG-BA NIK3RVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTBwMEm0O|Ih|ryP NEezWnBUSU6JRWK=
NCI-H1792 NHvPOFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\OUWdOUUN3ME2wMlA6PjF6IN88US=> NVHDWHRpW0GQR1XS
MCF7 MmK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrzTWM2OD1yLkC5Olc4KM7:TR?= M{DvbnNCVkeHUh?=
NCI-H2122 NVrR[nM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvrUYRKSzVyPUCuNFk4PDVizszN NVfMV4J4W0GQR1XS
EFO-27 M4WyfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTBwMEm5PVch|ryP NXnLb5BSW0GQR1XS
LB2241-RCC MmryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmn0TWM2OD1yLkGwNFU1KM7:TR?= NV7jTIdoW0GQR1XS
SN12C M1GwTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jFb2lEPTB;MD6xNFExPyEQvF2= MXzTRW5ITVJ?
A498 NFKxfZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwMUCxPEDPxE1? M2DreHNCVkeHUh?=
PANC-03-27 MoTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzaTWM2OD1yLkGwNlg3KM7:TR?= NFHqbGZUSU6JRWK=
NCI-H1581 NHPoO3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwMUCyPUDPxE1? M1OxfHNCVkeHUh?=
U-87-MG MnXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;WTWM2OD1yLkGwN|A4KM7:TR?= NV;VSFNqW0GQR1XS
G-401 NIXHPY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwMUCzOVMh|ryP M2q1NXNCVkeHUh?=
SiHa MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHucY9KUUN3ME2wMlExPDh4IN88US=> Mo\LV2FPT0WU
U251 MmLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlOxTWM2OD1yLkGwOVI2KM7:TR?= M4HCdHNCVkeHUh?=
MMAC-SF MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnLTWM2OD1yLkGwOVMyKM7:TR?= MmH5V2FPT0WU
BB65-RCC NFTMXldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfmTWM2OD1yLkGwOVU1KM7:TR?= NUi2TIkzW0GQR1XS
NKM-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjBdIJNUUN3ME2wMlExPjZ4IN88US=> Mk[xV2FPT0WU
HD-MY-Z MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX72NJlGUUN3ME2wMlExQDd|IN88US=> NHnCRZdUSU6JRWK=
TGBC11TKB M1nzNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMUC5NFMh|ryP M4HhVHNCVkeHUh?=
COLO-679 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;DTWM2OD1yLkGxNlEyKM7:TR?= MmnCV2FPT0WU
TE-8 NXn1VY96T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPifnFKSzVyPUCuNVEzPjRizszN NV\tUYVmW0GQR1XS
SK-MEL-28 MoPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnKyTWM2OD1yLkGxN|IyKM7:TR?= NES5SoNUSU6JRWK=
SH-4 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTwRpB3UUN3ME2wMlEyOzV4IN88US=> MV;TRW5ITVJ?
KALS-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTBwMUGzPVMh|ryP M4\LRXNCVkeHUh?=
RKO MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXDbGNKSzVyPUCuNVE4PjRizszN NVywXpBMW0GQR1XS
OMC-1 MkTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTTTWM2OD1yLkGxO|k4KM7:TR?= MlnvV2FPT0WU
BT-549 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTBwMUG3PVkh|ryP M3LEd3NCVkeHUh?=
NCI-H28 NHHFeWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTBwMUG4NVch|ryP MWHTRW5ITVJ?
RXF393 NHTu[HdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvOfpVKSzVyPUCuNVE6QDJizszN NUXzbHBVW0GQR1XS
COLO-829 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTBwMUKwNFUh|ryP NYriS5lyW0GQR1XS
HMV-II NFLhZlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHQ[HgyUUN3ME2wMlEzODJizszN NEXVV5hUSU6JRWK=
SW1990 NVv3[FVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwMUKxOVch|ryP NWTETGh2W0GQR1XS
NCI-H1437 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTBwMUKxOVch|ryP Mmj6V2FPT0WU
SNB75 MknTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYO4R|Q2UUN3ME2wMlEzOTZ7IN88US=> MnzYV2FPT0WU
EW-3 NGjKdIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HBV2lEPTB;MD6xNlY3OSEQvF2= NE\1SpJUSU6JRWK=
SAS Mo[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\xUFdIUUN3ME2wMlEzPjlizszN Mn7IV2FPT0WU
NCI-H1666 M4G2TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjvTWM2OD1yLkGyO|c1KM7:TR?= MX3TRW5ITVJ?
A375 NGr5eYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLCcINKSzVyPUCuNVI4PzhizszN NIDlXmJUSU6JRWK=
CAMA-1 NIP0OoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTBwMUK5NlQh|ryP MUDTRW5ITVJ?
HuP-T4 NFvCSVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\WTWM2OD1yLkGyPVQ{KM7:TR?= MW\TRW5ITVJ?
NCI-H292 MmK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmD3TWM2OD1yLkGzNVEh|ryP MnPFV2FPT0WU
PC-14 NX3zXooyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjXV41FUUN3ME2wMlE{OjFzIN88US=> M3fUZXNCVkeHUh?=
BPH-1 M2\wfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1O2[GlEPTB;MD6xN|QyKM7:TR?= MoXnV2FPT0WU
GAK MnTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXxbZBIUUN3ME2wMlE{PTZ5IN88US=> NGrEVW5USU6JRWK=
VMRC-RCZ MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\EOGlEPTB;MD6xN|c3OiEQvF2= M3zHdXNCVkeHUh?=
SK-MEL-24 NE\ENpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjLV5ZqUUN3ME2wMlE{QDdizszN NXTlOVZYW0GQR1XS
LB831-BLC NI\HO5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmj2TWM2OD1yLkGzPFg{KM7:TR?= MVvTRW5ITVJ?
NCI-H2452 NV7pXYxXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofSTWM2OD1yLkGzPVU3KM7:TR?= Mk\QV2FPT0WU
RT-112 MojiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHVTWM2OD1yLkG0NFM2KM7:TR?= MYjTRW5ITVJ?
GP5d M{nS[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmewTWM2OD1yLkG0NVA1KM7:TR?= MVvTRW5ITVJ?
LC-2-ad MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXaT|R3UUN3ME2wMlE1OTJzIN88US=> NFrhPWVUSU6JRWK=
MPP-89 M{\jd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIf6W2FKSzVyPUCuNVQyOjVizszN M1zVZXNCVkeHUh?=
NUGC-3 NWTidVIzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTBwMUS0O|gh|ryP MYTTRW5ITVJ?
GI-1 MnnLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHi3NJhKSzVyPUCuNVQ2PThizszN MWLTRW5ITVJ?
HCC1419 NW\xe4lET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjsW3lxUUN3ME2wMlE1PTd4IN88US=> MWHTRW5ITVJ?
SW1573 Mkf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3v[IJKSzVyPUCuNVQ4PThizszN MkDqV2FPT0WU
NCI-H2347 NH3DdWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzzTlhIUUN3ME2wMlE1QDN7IN88US=> NV3wVZhmW0GQR1XS
Mewo MnPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfYcmY4UUN3ME2wMlE1QDh7IN88US=> NVe2SnVKW0GQR1XS
639-V NXjyOZNqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDaRmNKSzVyPUCuNVUxOTNizszN MnOwV2FPT0WU
AsPC-1 NFLwb4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\GTWM2OD1yLkG1NlI2KM7:TR?= MoLnV2FPT0WU
NCI-H1648 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfC[2tKSzVyPUCuNVUzOzJizszN MWDTRW5ITVJ?
786-0 NHvWdnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTBwMUWzPFEh|ryP M{HtdHNCVkeHUh?=
ETK-1 NXzjTGY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWi1R2ZHUUN3ME2wMlE2QSEQvF2= MoflV2FPT0WU
BxPC-3 NUXycIRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LBTWlEPTB;MD6xOVk3PiEQvF2= M1fP[3NCVkeHUh?=
CAL-62 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwMU[xOlkh|ryP M4THVHNCVkeHUh?=
HCC1937 MorUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{e4SWlEPTB;MD6xOlI4PSEQvF2= NEL5bFFUSU6JRWK=
NCI-H1299 NVPCOnZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTBwMU[yPFUh|ryP NVvteoF7W0GQR1XS
SW1088 NH:wW3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37zZ2lEPTB;MD6xOlQyOyEQvF2= M2HJXXNCVkeHUh?=
FTC-133 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zlcGlEPTB;MD6xOlU1KM7:TR?= M2XaN3NCVkeHUh?=
OC-314 MmK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnVTWM2OD1yLkG2Olkh|ryP MkD4V2FPT0WU
SCC-9 NHqxNo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEK1enFKSzVyPUCuNVY4OTZizszN M4O5fnNCVkeHUh?=
HT-1376 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\MOlRKSzVyPUCuNVY6OzZizszN MnfZV2FPT0WU
U-2-OS NFmzdHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwMUexO|Mh|ryP NYLHXJV2W0GQR1XS
COLO-824 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPSO2t2UUN3ME2wMlE4Ojl2IN88US=> NUTYRVhTW0GQR1XS
BB30-HNC Ml7WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vjSmlEPTB;MD6xO|M{KM7:TR?= MWfTRW5ITVJ?
NCI-H2087 M1v4SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTBwMUezOlgh|ryP MlHYV2FPT0WU
NCI-H2170 MnjrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{f0VWlEPTB;MD6xO|U{PiEQvF2= NGHMWVlUSU6JRWK=
SK-OV-3 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfv[3dKSzVyPUCuNVc2PzFizszN M4DYXHNCVkeHUh?=
MZ7-mel NYWyXGNXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvsdphyUUN3ME2wMlE4PjR7IN88US=> MWDTRW5ITVJ?
NCI-H650 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XLdmlEPTB;MD6xO|Y5OiEQvF2= NGS2V3pUSU6JRWK=
KOSC-2 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HUZmlEPTB;MD6xO|c{PCEQvF2= MkPJV2FPT0WU
SCC-4 NXnzRWhXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrWPZBwUUN3ME2wMlE4Pzd5IN88US=> MoTyV2FPT0WU
MDA-MB-157 Mn;tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPyTWM2OD1yLkG4NFgzKM7:TR?= NYjIZlh[W0GQR1XS
KYSE-520 NU\QS5JOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fIeWlEPTB;MD6xPFIh|ryP MkDZV2FPT0WU
LK-2 M2H0fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHTWGtKSzVyPUCuNVg{ODNizszN MWXTRW5ITVJ?
KNS-81-FD MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvJOoNKSzVyPUCuNVg{QTRizszN NHLsT5lUSU6JRWK=
IGROV-1 MmDmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\qfpNLUUN3ME2wMlE5PDR|IN88US=> NXqyNWR2W0GQR1XS
DEL NGLYSI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nPVGlEPTB;MD6xPFQ2KM7:TR?= M132UXNCVkeHUh?=
NCI-H1395 MknsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXRRo1KSzVyPUCuNVg3QDJizszN NUjrPW13W0GQR1XS
JEG-3 MnHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HkbmlEPTB;MD6xPFcxPSEQvF2= NUP4WlBzW0GQR1XS
BCPAP NXuyflBNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1:xZ2lEPTB;MD6xPFg4OiEQvF2= MnjsV2FPT0WU
CAL-27 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXHTWM2OD1yLkG5NFIzKM7:TR?= M3LmbXNCVkeHUh?=
RD M2nDfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jGb2lEPTB;MD6xPVEyOyEQvF2= NF\ST|hUSU6JRWK=
RVH-421 NXywbFNFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwMUmxNVYh|ryP MoTaV2FPT0WU
Capan-2 M2HrWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4SwWGlEPTB;MD6xPVI2PiEQvF2= MXXTRW5ITVJ?
COLO-680N MoKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmryTWM2OD1yLkG5N|Y1KM7:TR?= MWfTRW5ITVJ?
NCI-H1650 MkjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mor4TWM2OD1yLkKwNFU4KM7:TR?= MYnTRW5ITVJ?
SBC-5 NV7IUVlZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjnPHpuUUN3ME2wMlIxOTF6IN88US=> NUmw[ppNW0GQR1XS
U031 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjVPWtKSzVyPUCuNlA2PDdizszN MmnFV2FPT0WU
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Ca9-22 NWi3eGhjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTRwNEW2PVEh|ryP NFrrOYVUSU6JRWK=
ES4 NHm2SIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTRwNEewPVUh|ryP MVXTRW5ITVJ?
ES6 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljQTWM2OD12LkS5OlU4KM7:TR?= NFq3eo9USU6JRWK=
DMS-114 NX;rUZZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2j1UmlEPTB;ND61OFY6OSEQvF2= NECwTG1USU6JRWK=
ONS-76 NGTaemJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWS4UndiUUN3ME20MlU4QTVizszN NYnNWndHW0GQR1XS
K-562 M2W4R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHn5[HdKSzVyPUSuO|M5OTRizszN NV;zZYMyW0GQR1XS
MHH-NB-11 MmLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;LTWM2OD12Lke1OFYyKM7:TR?= NVjBVZB6W0GQR1XS
Calu-3 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXH1R2xIUUN3ME20Mlc5PTR6IN88US=> MoDFV2FPT0WU
HT55 NGLibodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;Nb2lEPTB;ND64OFU1PSEQvF2= M{XLZ3NCVkeHUh?=
SK-N-FI Ml;4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3rTWM2OD12Lki1NFA6KM7:TR?= MV7TRW5ITVJ?
ES1 M3HQSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXvXY1bUUN3ME20Mlg3ODV5IN88US=> M1n3WnNCVkeHUh?=
SF126 NVX5VmV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nJ[2lEPTB;ND65N|E5PCEQvF2= MVHTRW5ITVJ?
ES5 NGfG[|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrWPWJKSzVyPUWuNVI1OjdizszN MlL2V2FPT0WU
LoVo M3jO[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XuXWlEPTB;NT6xOVg4OSEQvF2= M2PrRXNCVkeHUh?=
SNU-387 NV;KVYJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jwemlEPTB;NT6zNlM{QSEQvF2= NUDMRZQzW0GQR1XS
C8166 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HO[2lEPTB;NT6zOlM{QSEQvF2= NHzqTm9USU6JRWK=
LS-1034 M{TRNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTVwNEKzNFch|ryP M3L6dXNCVkeHUh?=
GR-ST MlTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPGdXFKSzVyPUWuOVIzODFizszN M2D5PXNCVkeHUh?=
NCI-H1092 MnvUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTVwN{K4OFMh|ryP M2HNdHNCVkeHUh?=
647-V NGq3UmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTVwN{S3NFYh|ryP NIDuUHFUSU6JRWK=
EW-13 NX;SW3RST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1H0ZmlEPTB;NT63OlYzPyEQvF2= MlTaV2FPT0WU
KGN NFrncVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFOxU|JKSzVyPU[uNFk6OjFizszN Mnf2V2FPT0WU
D-423MG NFrGXFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDXOXlKSzVyPU[uOFAzQDRizszN NGj4OXVUSU6JRWK=
ECC10 NXfTdYFbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjvc3FKSzVyPUeuNVAyODFizszN M1nx[3NCVkeHUh?=
TE-5 NFG2ZohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1j0PGlEPTB;Nz60NVI6QCEQvF2= NUPjPXJPW0GQR1XS
P12-ICHIKAWA NFXGUIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTNTWM2OD15LkS1OVI{KM7:TR?= MlrUV2FPT0WU
NCI-H82 MknWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTdwNEW3NFEh|ryP M3nVeXNCVkeHUh?=
NCI-H1993 NX;2S2wyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTdwOEOwOlMh|ryP NUfKNGJ4W0GQR1XS
RH-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3CTWM2OD15Lki1NlQ1KM7:TR?= MnrvV2FPT0WU
SW948 NUnyfmdRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3zTWM2OD15Lkm2NFQ6KM7:TR?= NXvpcYNVW0GQR1XS
CAL-33 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjzbZE2UUN3ME23Mlk6QTN6IN88US=> NXH5WIY{W0GQR1XS
U-266 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrDTWM2OD16LkG1O|c4KM7:TR?= NYLEcYw5W0GQR1XS
CAL-72 Mlz0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4ftN2lEPTB;OD6yNFMzKM7:TR?= M2DldHNCVkeHUh?=
SNU-423 NIPybWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTLVZpKSzVyPUmuN|Y3PjZizszN MYnTRW5ITVJ?
KG-1 NFPiO2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2qzcmlEPTB;OT61PFQ2PiEQvF2= NIHZe2ZUSU6JRWK=
HCC1395 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknDTWM2OD17LkmyN|UzKM7:TR?= MV3TRW5ITVJ?
BE-13 NEnVdINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIO4bYJKSzVyPUGwMlg5QTJizszN M1;lbHNCVkeHUh?=
MKN7 NIe3b45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTFyLkm3OlUh|ryP M1HRUnNCVkeHUh?=
697 NVnVfoNIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHS3WXdKSzVyPUGxMlE1PzJizszN MWXTRW5ITVJ?
LU-135 NHGwVHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rCcWlEPTB;MUGuNlMxPyEQvF2= MV;TRW5ITVJ?
ES7 NGTnT4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1S1WGlEPTB;MUGuN|MyOyEQvF2= MYrTRW5ITVJ?
SK-HEP-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;1R|VKSzVyPUGxMlc3PDZizszN M{HIXHNCVkeHUh?=
BEN NH\peopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVH5dIxEUUN3ME2xNU45PTFizszN MYXTRW5ITVJ?
NCI-H1770 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jPTWlEPTB;MUKuNVI3KM7:TR?= MXLTRW5ITVJ?
SW13 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPQcnNKSzVyPUGyMlE2PDFizszN NXvafmRVW0GQR1XS
MZ1-PC M1\lbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTF{LkW0OVIh|ryP MUfTRW5ITVJ?
Mo-T MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTF{Lke0NlEh|ryP NU\aVZQ{W0GQR1XS
HLE MljkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPtUVRDUUN3ME2xNk45OjF3IN88US=> NWHrNphMW0GQR1XS
RCC10RGB M3e3O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTF|Lk[3NUDPxE1? MmHlV2FPT0WU
COLO-320-HSR NEDPXlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPjd3JUUUN3ME2xN{44OzhzIN88US=> M3jrWnNCVkeHUh?=
BHT-101 NWrTTY1DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTRfJpKSzVyPUGzMlg{PDVizszN MkDjV2FPT0WU
OCUB-M MnHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlT0TWM2OD1zND6xOlAzKM7:TR?= NVj4eYxWW0GQR1XS
MEG-01 NXH6UGJuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vSZ2lEPTB;MUSuN|cxQCEQvF2= MmXJV2FPT0WU
RS4-11 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzwTWM2OD1zND63OFIh|ryP M17KXnNCVkeHUh?=
MN-60 NF2xZppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDk[21QUUN3ME2xOE44QDl2IN88US=> M4jqSXNCVkeHUh?=
NCI-H1304 M{fvV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTF3LkC0NlUh|ryP M2DyXHNCVkeHUh?=
Ramos-2G6-4C10 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7ETWM2OD1zNT6wOVgyKM7:TR?= M3HQTnNCVkeHUh?=
NCI-H2342 M3Phdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk[1TWM2OD1zNT6yNFQ1KM7:TR?= NIL5PIlUSU6JRWK=
LAN-6 NGLlfVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jXOGlEPTB;MUWuOFQyPCEQvF2= NHf2XGdUSU6JRWK=
JVM-2 NEXI[5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fIcGlEPTB;MUWuOVc1QCEQvF2= M4L2VXNCVkeHUh?=
P30-OHK MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XUfWlEPTB;MU[uNFYyPCEQvF2= NX7FTGlbW0GQR1XS
C-33-A NY[3ZYh7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPodXRKSzVyPUG2MlYzOTRizszN M{\yR3NCVkeHUh?=
RPMI-8866 M3nCNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTF4Lki0PVYh|ryP MUXTRW5ITVJ?
NCI-H630 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXXR|I6UUN3ME2xOk45PTN5IN88US=> MVzTRW5ITVJ?
KYSE-140 NEHSN4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFSxfZdKSzVyPUG3MlIxOjhizszN NIroZWhUSU6JRWK=
T84 NI[2VlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3z1TGlEPTB;MUiuPFY6PSEQvF2= NIDRNIhUSU6JRWK=
KU-19-19 M1LsU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTF6Lkm2NFgh|ryP M4PxUHNCVkeHUh?=
BALL-1 MkjPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;UZ2ZKSzVyPUG5MlM{QTlizszN NYfFR3NKW0GQR1XS
Calu-6 NF\jd4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTF7LkS5NkDPxE1? MXHTRW5ITVJ?
EGI-1 MoriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2Tsb2lEPTB;MUmuOVk5KM7:TR?= MYXTRW5ITVJ?
MFH-ino MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTF7Lke0OVQh|ryP NGLCcVFUSU6JRWK=
GB-1 NIGxT4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjUZ3YzUUN3ME2yNE4{PTN3IN88US=> MV\TRW5ITVJ?
NCI-H1693 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWK3V2NKUUN3ME2yNE43PTB3IN88US=> MX;TRW5ITVJ?
SW1116 NIDDVWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NESzU4ZKSzVyPUKwMlk{PjJizszN NWrIOHZEW0GQR1XS
H-EMC-SS M4nlUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHnclN6UUN3ME2yNk4xPDVizszN MnzHV2FPT0WU
D-502MG MlHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDXTWM2OD1{Mj64NlYyKM7:TR?= NX;vSYdpW0GQR1XS
IA-LM MlX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTBTWM2OD1{Mz6yOFk{KM7:TR?= M4jEdHNCVkeHUh?=
SW1463 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnOU5VKSzVyPUKzMlc6KM7:TR?= NYK3dJhYW0GQR1XS
JAR NIXZV4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HLTGlEPTB;MkSuN|I6OyEQvF2= MnnUV2FPT0WU
HT MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M134XGlEPTB;MkSuOFc2OyEQvF2= MXjTRW5ITVJ?
LCLC-103H NF\Jc41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTJ2Lki0OFkh|ryP NE\ifG1USU6JRWK=
SNU-449 NUm4fFY6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPPSGVKSzVyPUK0Mlg4PDFizszN M2f0V3NCVkeHUh?=
KE-37 MoLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PQSmlEPTB;MkWuNFkzQCEQvF2= MlLiV2FPT0WU
NCI-H1623 M3;WTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzl[W9KSzVyPUK3MlE{ODNizszN NH\5c45USU6JRWK=
MOLT-13 NWDqe3VmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTJ5LkO1NVYh|ryP MoPkV2FPT0WU
COLO-741 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHZdXRKSzVyPUOxMlM{OzNizszN MlTpV2FPT0WU
NB6 MlXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnEfZlKSzVyPUOyMlI5PzZizszN MX7TRW5ITVJ?
MOLT-16 NFrBSm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LnS2lEPTB;M{OuNFA2PSEQvF2= NWnHXW9NW0GQR1XS
IST-MES1 M1PENWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTN2LkC1OFEh|ryP NEfF[GVUSU6JRWK=
A4-Fuk NYDkSI57T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDFSYVKSzVyPUO1MlA3PiEQvF2= NEjtbWZUSU6JRWK=
CAL-85-1 MnnTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTN3LkK4NVch|ryP MVXTRW5ITVJ?
CCRF-CEM NGPqXZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTN5LkG1N|Yh|ryP NYDWSIc3W0GQR1XS
HAL-01 NX\ibI9kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTN6LkS4PFkh|ryP NFTyRY5USU6JRWK=
HEL NFLXOm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnaU3U1UUN3ME20N{4{PDB7IN88US=> MV3TRW5ITVJ?
EW-1 MnrLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rTeWlEPTB;NEOuOFc3QCEQvF2= M1HaWHNCVkeHUh?=
MDA-MB-231 NIHa[YVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTR3LkGxPVkh|ryP MYfTRW5ITVJ?
ABC-1 NHrnU29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTR4Lki1N|gh|ryP NYHscYRQW0GQR1XS
NCI-H446 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGn2cWxKSzVyPUS4MlUxPThizszN NFLKUY1USU6JRWK=
MHH-PREB-1 NX[2eY9KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\OdWlEPTB;NEmuOlAxPyEQvF2= MlHoV2FPT0WU
DOHH-2 M2fCXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTR7Lk[2OVYh|ryP NWDweHJGW0GQR1XS
GCT NHzMRmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;NTWM2OD12OT62PVc3KM7:TR?= NHvvbGpUSU6JRWK=

... Click to View More Cell Line Experimental Data

体内研究 17-AAG作用于携带3T3-src, B16或CT26移植瘤裸鼠,与Hsp90结合具有高亲和力,IC50为8-35 nM,而作用于正常组织时,IC50为200-600 nM。[1] 17-AAG按50 mg/kg左右剂量处理,引起AR, HER2, HER3, 和 Akt表达明显降低,降低达50%以上,这种作用存在剂量依赖性,结果导致雄激素依赖型 (CWR22)和非依赖型(CWR22R 和CWRSA6) 前列腺移植瘤生长受抑制,抑制率分别为67%, 80%和 68%。[2]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[1]
+ 展开

Hsp90结合实验:

纯化的Hsp90蛋白或过量表达HER-2的癌细胞(BT474, N87, SKOV3 和 SKBR3) 裂解物或BT474乳腺癌细胞溶于溶解buffer(20 mM HEPES, pH 7.3, 1 mM EDTA, 5 mM MgCl2, 100 mM KCl) ,与不同浓度17-AAG在4oC下温育30分钟,然后和生物素-GM链接的BioMag链霉亲和素磁珠在4oC下温育1小时。试管放置于磁架上,除去未结合的上清液。在溶解buffer中清洗三次磁珠,然后在SDS–PAGE 样本缓冲液中在95oC下加热5分钟。在SDS蛋白凝胶上进行样本分析,使用特点抗体进行Western Blotting。使用Bio-rad Fluor-S 多重图像测量Western Blot条带,计算抑制Hsp90与生物素-GM结合的百分数。测定IC50。
细胞实验:[1]
+ 展开
  • Cell lines: BT474, SKBR3, N87, SKOV3, MCF7, MDA468, Hs578T, Hs578Bst, A549, HT29, U87, SKMG3, HT1080, RPTEC, NDF, HMVEC, HMEC, HUVEC, 和 PBMC
  • Concentrations: 溶于DMSO, 终浓度为10 μM 左右
  • Incubation Time: 5天
  • Method: 细胞按每孔2000个接种在96孔板上,终培养体积为100 μL,培养24小时, 然后加入浓度不断增高的17-AAG,温育5天。使用 Celltiter 96 AQueous 非放射性细胞增殖检测试剂盒测定存活细胞数。测定IC50。
    (Only for Reference)
动物实验:[2]
+ 展开
  • Animal Models: 皮下注射雄激素依赖性CWR22移植瘤的雄性 nu/nu 无胸腺小鼠, 皮下注射雄激素非依赖性的CWR22R和CWRSA6移植瘤的雌性nu/nu 无胸腺小鼠。
  • Formulation: 溶于DMSO, 对照组用蛋磷脂(EPL)稀释
  • Dosages: 50 mg/kg 左右
  • Administration: 腹膜注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 100 mg/mL (170.73 mM)
Ethanol 5 mg/mL (8.53 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5%DMSO+corn oil
10mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 585.69
化学式

C31H43N3O8

CAS号 75747-14-7
稳定性 powder
in solvent
别名 CP127374,NSC-330507, KOS 953

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00577889 Completed Adenocarcinoma of the Pancreas|Recurrent Pancreatic Cancer|Stage IV Pancreatic Cancer National Cancer Institute (NCI) March 2008 Phase 2
NCT00577889 Completed Adenocarcinoma of the Pancreas|Recurrent Pancreatic Cancer|Stage IV Pancreatic Cancer National Cancer Institute (NCI) March 2008 Phase 2
NCT00546780 Completed Multiple Myeloma Bristol-Myers Squibb February 2008 Phase 3
NCT00546780 Completed Multiple Myeloma Bristol-Myers Squibb February 2008 Phase 3
NCT00093496 Completed Primary Peritoneal Cavity Cancer|Recurrent Ovarian Epithelial Cancer|Stage III Ovarian Epithelial Cancer|Stage IV Ovarian Epithelial Cancer National Cancer Institute (NCI) October 2007 Phase 2
NCT00093496 Completed Primary Peritoneal Cavity Cancer|Recurrent Ovarian Epithelial Cancer|Stage III Ovarian Epithelial Cancer|Stage IV Ovarian Epithelial Cancer National Cancer Institute (NCI) October 2007 Phase 2

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操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    What kind of subtypes does this compound inhibit? HSP90α or HSP90β ?

  • 回答:

    17-AAG can inhibit both HSP90α and HSP90β, but it is unclear how much are they affected respectively. You should note that Hsp90 derived from tumor cells has a 100-fold higher binding affinity for 17-AAG than that from normal cells according to this paper. http://www.nature.com.ezp-prod1.hul.harvard.edu/nature/journal/v425/n6956/full/nature01913.html

HSP (e.g. HSP90) Signaling Pathway Map

HSP (e.g. HSP90) Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID