Tanespimycin (17-AAG)

目录号：S1141 别名： CP127374,NSC-330507, KOS 953

Tanespimycin (17-AAG) Chemical Structure

Molecular Weight(MW): 585.69

Tanespimycin (17-AAG)是一种有效的HSP90抑制剂，无细胞试验中IC50为5 nM，作用于来自肿瘤细胞的HSP90比作用于来自正常细胞HSP90结合亲和力高100倍。Phase 2。

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客户购买Selleck的此次产品后发表的文献20篇：

客户使用该产品的9个实验数据：

  • (A) Cell lines were seeded in 96-well plates and treated with 10 nM of 17-AAG for 72 h. Cell survival was analyzed using CellTiter-Glo. Both parental H3122 cells (red bar) and H3122 CR cells (blue bar) show sensitivity to 17-AAG. (B) Suppression of ALK signaling by 17-AAG in resistant H3122 CR cells. H3122 parental and resistant cells were exposed to increasing concentrations of 17-AAG for 6 h.

    PNAS, 2011, 108: 7535-40. Tanespimycin (17-AAG) purchased from Selleck.

    (A) Treatment of DIPG cells with an HSP90 inhibitor, 17-AAG, resulted in decreased invasion toward SVZ hNPC CM at high doses. (B) Cell viability of DIPG cells treated with increasing doses of 17-AAG, by the CellTiter-Glo assay.

    Cell, 2017, 170(5):845-859.e19. Tanespimycin (17-AAG) purchased from Selleck.

  • SKBR3 cells were treated with FW-04-806 at 10, 20, 40 uM for 24 h; 17AAG was used as a positive control at 1 and 2 uM. Hsp70, Hsp90, and Cdc37 protein level were analyzed with western blotting using relevant antibodies.

    Mol Cancer 2014 13, 150. Tanespimycin (17-AAG) purchased from Selleck.

    Western blot analysis of immunoprecipitated Hsp90/BIP complexes in MOLT-4 (T-ALL) and RS4;11 (B-ALL) treated for 22 h with CX-4945 (5 μM) and bortezomib (2.5 nM) either alone or in combination. 500 μg of protein lysates were immunoprecipitated with anti-Hsp90 antibody. Relative Induction values (Rel.Ind.) were obtained by normalizing to Hsp90 bands density. 17-AAG: tanespimycin.

    Oncotarget, 2015, 51: S659-S660. Tanespimycin (17-AAG) purchased from Selleck.

  • Co-IP analyses of direct interaction between HSP90 and HIF-1α in 17-AAG (5 μM)-treated HSCs using antibodies against HSP90, HIF-1α or IgG (n = 2).

    Br J Pharmacol, 2017, 174(5):409-423. Tanespimycin (17-AAG) purchased from Selleck.

    Treatment with an Hsp90 inhibitor results in a dose-dependent decrease in complex IV activity. A, because Hsp90 levels were reduced by 80%, in PINK1 null dopaminergic neuronal cells, the effects of specific inhibition of Hsp90 using 17-AAG were analyzed in wild-type neuronal cells. Both complex IV activity and Hsp60 levels were decreased significantly in 17-AAG-treated cells in a dose-dependent manner. B, in contrast, 17-AAG treatment did not affect expression of Hsp90 and LRPPRC.

    J Biol Chem 2012 287, 44109-20. Tanespimycin (17-AAG) purchased from Selleck.

  • UPR modulators destabilize mSmoM2. NIH 3T3 cells expressing mSmoM2 protein were treated with HSP90 inhibitors 17-AAG (50 uM and 100 uM) and SNX-2112 (25 uM and 50 uM) and the proteasome inhibitor bortezomib (25 uM and 50 uM) for 4 h prior to lysis. DMSO was the vehicle control. Western blotting of whole-cell lysates revealed mSmoM2 protein to be destabilized in response to HSP-90 inhibitors but not in response to bortezomib. Tubulin was the loading control. CHOP results indicate ER stress.

    Mol Cell Biol 2013 33(12), 2375-87. Tanespimycin (17-AAG) purchased from Selleck.

    Hsp90 is up-regulated during aging. Whole-cell extracts were prepared from young (PD 20) and old (PD 40) HFSN1 cells. c HFSN1 cells (PD 40) were treated with different concentration of the Hsp90 inhibitor (17-AAG) and then re-incubated for 24 h. Whole-cell extracts were prepared and analyzed by western blot using the indicated antibodies.

    Age 2013 35, 549-62. Tanespimycin (17-AAG) purchased from Selleck.

  • Four types of the colon cancer cells with indicated K-Ras phenotype were incubated with indicated concentration of 17-AAG for 24 h, which were then analyzed for protein expression by WB.

    Oncotarget 2014 5, 4269-82. Tanespimycin (17-AAG) purchased from Selleck.

产品安全说明书

HSP (e.g. HSP90)抑制剂选择性比较

生物活性

产品描述 Tanespimycin (17-AAG)是一种有效的HSP90抑制剂，无细胞试验中IC50为5 nM，作用于来自肿瘤细胞的HSP90比作用于来自正常细胞HSP90结合亲和力高100倍。Phase 2。
特性 17-AAG对正常细胞的毒性很小。
靶点
HSP90 [1]
(Cell-free assay)
5 nM
体外研究

17-AAG是格尔德霉素类似物, 但是与过量表达HER-2的癌细胞 (BT474, N87, SKOV3 和SKBR3)或BT474乳腺细胞衍生的Hsp90亲和力高100多倍，IC50为5-6 nM, 而作用于正常人类原代细胞时，IC50为400-943 nM, 因为肿瘤Hsp90 处于多伴复合体状态，具有高ATP酶活性，而正常细胞Hsp90 处于潜在未结合状态, 且直接与那些细胞中17-AAG毒性相关。[1]17-AAG 引起HER2, HER3, Akt，突变和野生型雄激素受体(AR)降解，导致前列腺细胞如LNCaP, LAPC-4, DU-145,和PC-3中RB依赖的 G1 期生长停顿，IC50为25-45 nM。[2]除了诱导改变野生型BCR-ABL的Ba/F3细胞凋亡, IC50为5.2 μM, 17-AAG还通过诱导野生型和突变型 BCR-ABL蛋白降解，而诱导改变抗 Imatinib Mesylate的 T315I和 E255K BCR-ABL突变型细胞生长，IC50分别为2.3 μM 和 1.0 μM。[3]
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A549 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnW2TWM2OD1yLkCwNFMxOyEQvF2= Mn3wV2FPT0WU
IST-MEL1 NEHkTHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljuTWM2OD1yLkCwNFQxPyEQvF2= M1XkcnNCVkeHUh?=
NCI-SNU-1 NFTZRYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLGTWM2OD1yLkCwNlA4KM7:TR?= M1uxenNCVkeHUh?=
FADU MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULOZ5hUUUN3ME2wMlAxOjB7IN88US=> Mo\nV2FPT0WU
C32 NIfGR|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVW2VFU3UUN3ME2wMlAxOzB2IN88US=> NXe2RWxiW0GQR1XS
D-566MG NXXmTodpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\iWmlEPTB;MD6wNFM6KM7:TR?= NIe4RoFUSU6JRWK=
LXF-289 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;YSWNTUUN3ME2wMlAxPDF7IN88US=> NETCVXJUSU6JRWK=
HGC-27 MmG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkizTWM2OD1yLkCwOVEh|ryP MmWzV2FPT0WU
RPMI-7951 NIjDfGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUeyWpRXUUN3ME2wMlAxPzF5IN88US=> MlnqV2FPT0WU
HSC-3 NWThS5ZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml35TWM2OD1yLkCwPVI6KM7:TR?= M3W1XnNCVkeHUh?=
MIA-PaCa-2 NUO0SmhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXwTWM2OD1yLkCxNFA6KM7:TR?= MVHTRW5ITVJ?
KS-1 M2XDXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn6zTWM2OD1yLkCxN|U2KM7:TR?= NYHGfVhRW0GQR1XS
CAL-51 M33Lbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTxXVVVUUN3ME2wMlAyPDB3IN88US=> NIrJUGlUSU6JRWK=
MDA-MB-361 NF;Ve|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmG3TWM2OD1yLkCxOFk2KM7:TR?= MlfEV2FPT0WU
TI-73 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPxdmx[UUN3ME2wMlAyPzl4IN88US=> NIXoZWtUSU6JRWK=
AGS NHz3R4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\xeIQ1UUN3ME2wMlAyQTN6IN88US=> NUnQSJZzW0GQR1XS
NCI-H460 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXm0XpBUUUN3ME2wMlAyQTd2IN88US=> MX;TRW5ITVJ?
A204 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILhT4FKSzVyPUCuNFIzPDlizszN MYTTRW5ITVJ?
CHL-1 NH7YNItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\Uc5pzUUN3ME2wMlAzOjVzIN88US=> MmHvV2FPT0WU
DU-4475 MlHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIi2[29KSzVyPUCuNFIzPjFizszN MlzNV2FPT0WU
CGTH-W-1 MnHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHSTWM2OD1yLkCyN|Q6KM7:TR?= M{XMR3NCVkeHUh?=
HCC2218 M37scGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjKeVhKSzVyPUCuNFI1QTRizszN M2j4bHNCVkeHUh?=
A2780 NWrpfIZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\FWGlEPTB;MD6wNlU{OSEQvF2= Mn7DV2FPT0WU
NCI-H720 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXhbJJKSzVyPUCuNFI2PDZizszN NULuWWNwW0GQR1XS
NCI-N87 NH;xdZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{SyRmlEPTB;MD6wNlU6OyEQvF2= NWfpRVhIW0GQR1XS
CHP-212 NXzNVVQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkT1TWM2OD1yLkCyOlI5KM7:TR?= M1jSPXNCVkeHUh?=
NCI-H23 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwMEK2OlUh|ryP M2jtSHNCVkeHUh?=
D-263MG MonrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2Ljb2lEPTB;MD6wNlc5PiEQvF2= MV;TRW5ITVJ?
ME-180 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTBwMEK4PVEh|ryP NVTKWJROW0GQR1XS
SW982 NV\vPXhjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTBwMEK5PVkh|ryP M1LBXHNCVkeHUh?=
OE19 MmHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3iwWWlEPTB;MD6wN|A4PyEQvF2= NUjZTVlWW0GQR1XS
SK-LU-1 NVrW[|F[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofNTWM2OD1yLkCzNFgzKM7:TR?= M1;kfnNCVkeHUh?=
H4 MoHxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vVNWlEPTB;MD6wN|A6KM7:TR?= NF3nZ4VUSU6JRWK=
HT-144 NFHKUGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwMEOwPVMh|ryP NIThOXpUSU6JRWK=
SK-UT-1 NED3eWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rRNmlEPTB;MD6wN|E4QCEQvF2= NHHLdI1USU6JRWK=
D-336MG M1flcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwMEOzNFkh|ryP NHr2bHZUSU6JRWK=
MDA-MB-175-VII MknoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlj0TWM2OD1yLkCzN|U1KM7:TR?= NFv1cppUSU6JRWK=
GAMG Ml3SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4Twb2lEPTB;MD6wN|Q{PSEQvF2= NHzOflBUSU6JRWK=
CP50-MEL-B NIDI[2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXhTWM2OD1yLkCzOFUh|ryP NYPWdpZ4W0GQR1XS
OVCAR-5 M1PpPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTBwMEO0PEDPxE1? NIjBeWVUSU6JRWK=
SK-MES-1 MlvZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDBSIdYUUN3ME2wMlA{PjB4IN88US=> NGTDfWxUSU6JRWK=
VM-CUB-1 NV\1c3BJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDVTWM2OD1yLkCzOlU4KM7:TR?= M1rEcXNCVkeHUh?=
WM-115 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPPSXZpUUN3ME2wMlA{PzZ{IN88US=> MX7TRW5ITVJ?
DSH1 NYS0dJdvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGO2Z45KSzVyPUCuNFM5ODdizszN M2DrS3NCVkeHUh?=
Becker M1H4Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\YTWM2OD1yLkCzPFg2KM7:TR?= NGfKbFlUSU6JRWK=
SW962 NH3i[5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7qVVZKSzVyPUCuNFM6PDVizszN M4fIOnNCVkeHUh?=
TYK-nu NUDSd49[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn:2TWM2OD1yLkCzPVg2KM7:TR?= MVXTRW5ITVJ?
HO-1-N-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXKwS|lHUUN3ME2wMlA1ODJzIN88US=> M3v1S3NCVkeHUh?=
T98G Mn3nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\mWYpKSzVyPUCuNFQyODNizszN NXHjeId{W0GQR1XS
ACN MmfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXrOGRKSzVyPUCuNFQyPjJizszN NYLxNGluW0GQR1XS
SW780 MkTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwMESyNFMh|ryP NYfsRo5DW0GQR1XS
Detroit562 M1PFS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\GOWlEPTB;MD6wOFI{QSEQvF2= MWPTRW5ITVJ?
BB49-HNC NX7tcYJUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHX1SoJKSzVyPUCuNFQzPDNizszN M{HjSXNCVkeHUh?=
HN M3fN[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPQboxMUUN3ME2wMlA1Ojd{IN88US=> MkjPV2FPT0WU
H9 NXHDXIt6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwMESzO|Eh|ryP MXLTRW5ITVJ?
VA-ES-BJ NIDVVpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3iSZJKSzVyPUCuNFQ1PDdizszN MYDTRW5ITVJ?
MEL-JUSO MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nKN2lEPTB;MD6wOFQ4PSEQvF2= NFvJO5hUSU6JRWK=
BT-474 M4\NUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTBwMES1JO69VQ>? MlHzV2FPT0WU
CaR-1 NUnXTJdqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37lcWlEPTB;MD6wOFU1QSEQvF2= MkexV2FPT0WU
PSN1 NFPhb3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\6OmlEPTB;MD6wOFYxOyEQvF2= MUXTRW5ITVJ?
KYSE-510 NIDpRZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvMTWM2OD1yLkC0OlQ6KM7:TR?= MmG0V2FPT0WU
KP-4 M4T2eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPJTWM2OD1yLkC0O|U{KM7:TR?= Mo\kV2FPT0WU
KYSE-410 NHGwcmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfpWYVOUUN3ME2wMlA1Pzd{IN88US=> NXru[WIzW0GQR1XS
G-402 NXHERnQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkG0TWM2OD1yLkC0O|g6KM7:TR?= M1jXT3NCVkeHUh?=
DOK NHjpXWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwMES5NFIh|ryP MnXXV2FPT0WU
COR-L88 NGHBUWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLUTWM2OD1yLkC0PVEzKM7:TR?= MUjTRW5ITVJ?
SKG-IIIa M3zrcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTBwMES5PFYh|ryP M4rxW3NCVkeHUh?=
AN3-CA M2jlWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfvSZNKSzVyPUCuNFUh|ryP MUnTRW5ITVJ?
SW48 MnLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF71bpFKSzVyPUCuNFUxOzlizszN MlGwV2FPT0WU
YKG-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwMEWwO|Eh|ryP NE\kS5pUSU6JRWK=
KYSE-150 NUnEd|lZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTBwMEWyN|Uh|ryP MXnTRW5ITVJ?
HuO-3N1 M3\xZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvFS|h{UUN3ME2wMlA2OjN5IN88US=> MnTMV2FPT0WU
LB1047-RCC NUTwfoRPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDTTWM2OD1yLkC1Nlk3KM7:TR?= MXrTRW5ITVJ?
NCI-H2030 NHX3OHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\pOYJbUUN3ME2wMlA2PDF2IN88US=> MUXTRW5ITVJ?
YH-13 NEjFOlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzHbWRKSzVyPUCuNFU4OjJizszN NYjlVJFoW0GQR1XS
5637 NVnYc5NDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml6xTWM2OD1yLkC1O|Qh|ryP NXPFVW1sW0GQR1XS
LOXIMVI M3nZWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTBwMEW4O|Ih|ryP M4qzWnNCVkeHUh?=
GT3TKB MmrHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGX1WVRKSzVyPUCuNFU6PDJizszN NWjSRXRbW0GQR1XS
TCCSUP MnfWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzncZNKSzVyPUCuNFU6PjRizszN MmfLV2FPT0WU
EPLC-272H NWj3[XZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYf5fpliUUN3ME2wMlA3OjB3IN88US=> NXG3[XU5W0GQR1XS
LU-99A NVzQZYpOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELzbnpKSzVyPUCuNFYzOzdizszN MU\TRW5ITVJ?
NCI-H1755 Mo\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjXTWM2OD1yLkC2N|QyKM7:TR?= MnvaV2FPT0WU
KM12 Ml60S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTBwME[zOFgh|ryP NWfK[JdHW0GQR1XS
SF295 NHu2NGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTBwME[0OVIh|ryP MmPGV2FPT0WU
MZ2-MEL NXv2NW1QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTBwME[1OVMh|ryP Mlm0V2FPT0WU
HEC-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\oUmlEPTB;MD6wOlU5QCEQvF2= NGD6e|dUSU6JRWK=
SW684 NH7vcnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwME[1PVEh|ryP NVX0[W8xW0GQR1XS
SF539 NEjsS4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUe1NFZQUUN3ME2wMlA3PjhzIN88US=> M1z2dnNCVkeHUh?=
GMS-10 M1HRXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGT2PYxKSzVyPUCuNFY3QTlizszN MkH1V2FPT0WU
MV-4-11 M4fV[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nWTGlEPTB;MD6wOlgxOyEQvF2= MXzTRW5ITVJ?
HT-29 M4fGT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzKR2x6UUN3ME2wMlA3QTF7IN88US=> M4fyWnNCVkeHUh?=
23132-87 M{XEVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnj[5dGUUN3ME2wMlA3QTVizszN NETXS3pUSU6JRWK=
SW620 MkTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zmfWlEPTB;MD6wO|AzPiEQvF2= NXK0SnNjW0GQR1XS
HCC1806 NWSyZXBHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF:5ZnpKSzVyPUCuNFcyOzFizszN MWDTRW5ITVJ?
Hs-578-T NYLS[VNNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwMEeyNFgh|ryP NG\uXlFUSU6JRWK=
A2058 MlLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPsPXZKSzVyPUCuNFczOjhizszN M1eweXNCVkeHUh?=
MEL-HO NFWzWZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXxXJhEUUN3ME2wMlA4OjV3IN88US=> NEn5PWhUSU6JRWK=
HCC2998 MkDLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4W3SmlEPTB;MD6wO|M1PyEQvF2= NFH1[JNUSU6JRWK=
HuO9 NWPZZ5NkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;sTWM2OD1yLkC3OVg6KM7:TR?= NE[4e4ZUSU6JRWK=
CAL-39 NFnVOINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTBwMEe3OlYh|ryP M2fRSXNCVkeHUh?=
M14 Mmf6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnNcpNxUUN3ME2wMlA4QTF|IN88US=> NEW1Tm1USU6JRWK=
BFTC-909 M1\JSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2r6VWlEPTB;MD6wO|k3QSEQvF2= Mn\UV2FPT0WU
TE-11 MkXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXJOo5KSzVyPUCuNFc6QTZizszN NFfZd5JUSU6JRWK=
TGBC1TKB MnnyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPOVZhDUUN3ME2wMlA5ODR|IN88US=> NGLRSYdUSU6JRWK=
L-363 NWjYW3pVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NECwZo1KSzVyPUCuNFgzODZizszN NULzXlhOW0GQR1XS
A431 NXKwWoJVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfQTWM2OD1yLkC4NlEh|ryP M{G4XXNCVkeHUh?=
MKN45 NUPlblBET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVruUJo6UUN3ME2wMlA5OjF7IN88US=> M3i5UHNCVkeHUh?=
HT-1080 M3nFfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwMEi0N|kh|ryP MmrXV2FPT0WU
OVCAR-8 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnmwTWM2OD1yLkC4OlIzKM7:TR?= NVyxXI5NW0GQR1XS
LCLC-97TM1 M{PKcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTBwMEi3Nlgh|ryP MnP6V2FPT0WU
M059J M2T1fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3yzTGlEPTB;MD6wPVAzPyEQvF2= MoP3V2FPT0WU
SK-MEL-2 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjWSoxKSzVyPUCuNFkxPiEQvF2= Ml;hV2FPT0WU
TE-1 NELpdY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PRTGlEPTB;MD6wPVIxPCEQvF2= NILxXm5USU6JRWK=
KYSE-180 M163Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLoTWM2OD1yLkC5NlYzKM7:TR?= MmSyV2FPT0WU
D-247MG NI\3[25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4[x[GlEPTB;MD6wPVQ2PSEQvF2= NWTuPXlNW0GQR1XS
8-MG-BA M1LKbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwMEm0O|Ih|ryP MkDCV2FPT0WU
NCI-H1792 NEP1XpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGW2blVKSzVyPUCuNFk3OThizszN MWrTRW5ITVJ?
MCF7 Mk\3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTBwMEm2O|ch|ryP NEfm[o1USU6JRWK=
NCI-H2122 NV36NZpbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HvW2lEPTB;MD6wPVc1PSEQvF2= NGfQeIlUSU6JRWK=
EFO-27 M17JUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGX2SVRKSzVyPUCuNFk6QTdizszN MXjTRW5ITVJ?
LB2241-RCC NIDxNnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTZcZNNUUN3ME2wMlExODV2IN88US=> NEf3SG9USU6JRWK=
SN12C NGLaRYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;uV2lEPTB;MD6xNFExPyEQvF2= NVnWe3RQW0GQR1XS
A498 NFHNS|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHftfINKSzVyPUCuNVAyQCEQvF2= NVfOToVqW0GQR1XS
PANC-03-27 MmC0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTpTWM2OD1yLkGwNlg3KM7:TR?= NIK1bIFUSU6JRWK=
NCI-H1581 NXS4TVQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTBwMUCyPUDPxE1? NXOwOJF7W0GQR1XS
U-87-MG M1Gwe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1Xuc2lEPTB;MD6xNFMxPyEQvF2= Mk\QV2FPT0WU
G-401 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWn4VnNXUUN3ME2wMlExOzV|IN88US=> MX;TRW5ITVJ?
SiHa NXfHWW5LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvJWlFKSzVyPUCuNVA1QDZizszN NUnsTWJYW0GQR1XS
U251 M1j4V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\zTWM2OD1yLkGwOVI2KM7:TR?= NG[0[4VUSU6JRWK=
MMAC-SF MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvFTWM2OD1yLkGwOVMyKM7:TR?= Mke5V2FPT0WU
BB65-RCC M2fUPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPXTWM2OD1yLkGwOVU1KM7:TR?= NV7KPI04W0GQR1XS
NKM-1 NHOyfXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTBwMUC2OlYh|ryP NHT3RotUSU6JRWK=
HD-MY-Z NHX3PFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LFemlEPTB;MD6xNFg4OyEQvF2= MoTwV2FPT0WU
TGBC11TKB M3n5Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLoUZpKSzVyPUCuNVA6ODNizszN NHrZXYpUSU6JRWK=
COLO-679 MlnCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvhTWM2OD1yLkGxNlEyKM7:TR?= NXzYfotuW0GQR1XS
TE-8 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwMUGyOlQh|ryP M1v4e3NCVkeHUh?=
SK-MEL-28 NYTBOIxpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfVVppKSzVyPUCuNVE{OjFizszN NVT4elFYW0GQR1XS
SH-4 M3Xjemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUexVlBHUUN3ME2wMlEyOzV4IN88US=> MX;TRW5ITVJ?
KALS-1 MkfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknLTWM2OD1yLkGxN|k{KM7:TR?= M37ySXNCVkeHUh?=
RKO NYTDemlCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jEUGlEPTB;MD6xNVc3PCEQvF2= MoruV2FPT0WU
OMC-1 NUXEWlN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLKW3lKSzVyPUCuNVE4QTdizszN MlrNV2FPT0WU
BT-549 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHRemhKSzVyPUCuNVE4QTlizszN NH;UUYZUSU6JRWK=
NCI-H28 NGSzeG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETMcItKSzVyPUCuNVE5OTdizszN NXS5bHhlW0GQR1XS
RXF393 NVrpWFcyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\PPVNYUUN3ME2wMlEyQTh{IN88US=> NEjySGlUSU6JRWK=
COLO-829 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHv5W2dKSzVyPUCuNVIxODVizszN MmKwV2FPT0WU
HMV-II MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTBwMUKwNkDPxE1? NFXK[IhUSU6JRWK=
SW1990 NVK0O3V5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37sXGlEPTB;MD6xNlE2PyEQvF2= M2i1enNCVkeHUh?=
NCI-H1437 M1HSSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3xTWM2OD1yLkGyNVU4KM7:TR?= NUC3clY3W0GQR1XS
SNB75 M2HidWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTBwMUKxOlkh|ryP NHnPT2pUSU6JRWK=
EW-3 M{W1XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NED0U2RKSzVyPUCuNVI3PjFizszN NEPIRXFUSU6JRWK=
SAS NEKzT5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfiXWxKSzVyPUCuNVI3QSEQvF2= MlzNV2FPT0WU
NCI-H1666 M3;MNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDDTWM2OD1yLkGyO|c1KM7:TR?= MWTTRW5ITVJ?
A375 NFTBZ4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rzdmlEPTB;MD6xNlc4QCEQvF2= NEiwfItUSU6JRWK=
CAMA-1 Mo\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nsfGlEPTB;MD6xNlkzPCEQvF2= MWjTRW5ITVJ?
HuP-T4 M3HjTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;nZW03UUN3ME2wMlEzQTR|IN88US=> MmLNV2FPT0WU
NCI-H292 NGXsSo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NED4dJRKSzVyPUCuNVMyOSEQvF2= M{W4ZnNCVkeHUh?=
PC-14 M3rCdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMUOyNVEh|ryP M2roS3NCVkeHUh?=
BPH-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7CTWM2OD1yLkGzOFEh|ryP NYDMVoVzW0GQR1XS
GAK NGPUbmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfucFRKSzVyPUCuNVM2PjdizszN MVjTRW5ITVJ?
VMRC-RCZ NWL1d4Y5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXr[WNGUUN3ME2wMlE{PzZ{IN88US=> Mn3EV2FPT0WU
SK-MEL-24 NGK4eIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDxbFZ6UUN3ME2wMlE{QDdizszN NWnQTJgyW0GQR1XS
LB831-BLC MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwMUO4PFMh|ryP NVfEboZ7W0GQR1XS
NCI-H2452 NWDKWlVjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHz1WWdKSzVyPUCuNVM6PTZizszN M1vxVHNCVkeHUh?=
RT-112 NGHmZVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;kXGRKSzVyPUCuNVQxOzVizszN NVLXfIlwW0GQR1XS
GP5d NETrendIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTBwMUSxNFQh|ryP NWLScXVJW0GQR1XS
LC-2-ad M2XRNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\1TWM2OD1yLkG0NVIyKM7:TR?= NIDKVlhUSU6JRWK=
MPP-89 M{HIVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDzPWhyUUN3ME2wMlE1OTJ3IN88US=> NWPlUXZRW0GQR1XS
NUGC-3 NEfqXINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TGRmlEPTB;MD6xOFQ4QCEQvF2= Mmf4V2FPT0WU
GI-1 M4\Tb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojhTWM2OD1yLkG0OVU5KM7:TR?= MmrtV2FPT0WU
HCC1419 NIm4cmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvXRo1CUUN3ME2wMlE1PTd4IN88US=> NEjrVpBUSU6JRWK=
SW1573 NHraW2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrJTWM2OD1yLkG0O|U5KM7:TR?= NWjIbotrW0GQR1XS
NCI-H2347 NVXDU|FpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{KwTmlEPTB;MD6xOFg{QSEQvF2= MUjTRW5ITVJ?
Mewo NIf3bHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{OyUGlEPTB;MD6xOFg5QSEQvF2= NWHoW3VSW0GQR1XS
639-V Ml7kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETHNW5KSzVyPUCuNVUxOTNizszN NXnONlJbW0GQR1XS
AsPC-1 NFH5PJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfmPXZPUUN3ME2wMlE2OjJ3IN88US=> MXHTRW5ITVJ?
NCI-H1648 MoDaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TiZWlEPTB;MD6xOVI{OiEQvF2= MoTwV2FPT0WU
786-0 NFHGS4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLuOYFKSzVyPUCuNVU{QDFizszN MmrMV2FPT0WU
ETK-1 MliwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV6xNnRIUUN3ME2wMlE2QSEQvF2= MoXhV2FPT0WU
BxPC-3 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvV[mczUUN3ME2wMlE2QTZ4IN88US=> NHPJe3NUSU6JRWK=
CAL-62 MnfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFT2N|FKSzVyPUCuNVYyPjlizszN MVfTRW5ITVJ?
HCC1937 MoTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;UfFBiUUN3ME2wMlE3Ojd3IN88US=> NIO0VVlUSU6JRWK=
NCI-H1299 NULJWZlVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nWe2lEPTB;MD6xOlI5PSEQvF2= MYLTRW5ITVJ?
SW1088 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jwS2lEPTB;MD6xOlQyOyEQvF2= MV3TRW5ITVJ?
FTC-133 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTBwMU[1OEDPxE1? MnfZV2FPT0WU
OC-314 NVTycI0xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEi1O4VKSzVyPUCuNVY3QSEQvF2= NULodVZ4W0GQR1XS
SCC-9 Mn\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorXTWM2OD1yLkG2O|E3KM7:TR?= MoP2V2FPT0WU
HT-1376 NVj5Tpg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37QTmlEPTB;MD6xOlk{PiEQvF2= M{PRRXNCVkeHUh?=
U-2-OS NIDV[lNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLQcXZGUUN3ME2wMlE4OTd|IN88US=> MkPuV2FPT0WU
COLO-824 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\tTWM2OD1yLkG3Nlk1KM7:TR?= NGPQRYRUSU6JRWK=
BB30-HNC MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfQTWM2OD1yLkG3N|Mh|ryP Mn\PV2FPT0WU
NCI-H2087 MmXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwMUezOlgh|ryP NWC3WoVMW0GQR1XS
NCI-H2170 M{\aUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3xTWM2OD1yLkG3OVM3KM7:TR?= NXf4WFQ4W0GQR1XS
SK-OV-3 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwMUe1O|Eh|ryP NUXGSIQ{W0GQR1XS
MZ7-mel NVPYN5ppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwMUe2OFkh|ryP MlnTV2FPT0WU
NCI-H650 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTBwMUe2PFIh|ryP MV\TRW5ITVJ?
KOSC-2 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37MbGlEPTB;MD6xO|c{PCEQvF2= MWfTRW5ITVJ?
SCC-4 MnzIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFq0cGRKSzVyPUCuNVc4PzdizszN NXzrZ5FOW0GQR1XS
MDA-MB-157 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFToVVZKSzVyPUCuNVgxQDJizszN MXrTRW5ITVJ?
KYSE-520 NXPsV2plT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PTUGlEPTB;MD6xPFIh|ryP NXfWU4wyW0GQR1XS
LK-2 Mm\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnDTWM2OD1yLkG4N|A{KM7:TR?= MX3TRW5ITVJ?
KNS-81-FD Mn7wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTBwMUizPVQh|ryP M17pSnNCVkeHUh?=
IGROV-1 NIXXcW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTBwMUi0OFMh|ryP M3rIVXNCVkeHUh?=
DEL NELyVIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEi4cWhKSzVyPUCuNVg1PSEQvF2= M2rHPHNCVkeHUh?=
NCI-H1395 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWeyNoloUUN3ME2wMlE5Pjh{IN88US=> MX7TRW5ITVJ?
JEG-3 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwMUi3NFUh|ryP NFnpWIpUSU6JRWK=
BCPAP MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLXTWM2OD1yLkG4PFczKM7:TR?= NILTNHZUSU6JRWK=
CAL-27 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrLXXVMUUN3ME2wMlE6ODJ{IN88US=> MYfTRW5ITVJ?
RD MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXzSXVkUUN3ME2wMlE6OTF|IN88US=> NUfGXJNYW0GQR1XS
RVH-421 NYfrTIg4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFL0OIFKSzVyPUCuNVkyOTZizszN MoniV2FPT0WU
Capan-2 NGrRSphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3G[GZKSzVyPUCuNVkzPTZizszN MUjTRW5ITVJ?
COLO-680N NGPTVZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnEfYpKSzVyPUCuNVk{PjRizszN NFTUNHFUSU6JRWK=
NCI-H1650 MlvnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnOOJN6UUN3ME2wMlIxODV5IN88US=> NUHCcm9wW0GQR1XS
SBC-5 NIXhdo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTBwMkCxNVgh|ryP MXXTRW5ITVJ?
U031 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPuUIFvUUN3ME2wMlIxPTR5IN88US=> NYPsT3ZqW0GQR1XS
S-117 NGHUTIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLodGxwUUN3ME2wMlIxPTZ2IN88US=> M3;iU3NCVkeHUh?=
DoTc2-4510 NGPZPXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTBwMkC3Olkh|ryP MV7TRW5ITVJ?
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ES4 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTRwNEewPVUh|ryP Mn3rV2FPT0WU
ES6 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoT3TWM2OD12LkS5OlU4KM7:TR?= M1TrSXNCVkeHUh?=
DMS-114 NYPXXZhkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjPTWM2OD12LkW0OlkyKM7:TR?= MWrTRW5ITVJ?
ONS-76 M{jwdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULHTIRCUUN3ME20MlU4QTVizszN MUfTRW5ITVJ?
K-562 MoGxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTtPW9sUUN3ME20Mlc{QDF2IN88US=> MYjTRW5ITVJ?
MHH-NB-11 MmHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TpTGlEPTB;ND63OVQ3OSEQvF2= MVvTRW5ITVJ?
Calu-3 NUTr[mhoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX[3OFlFUUN3ME20Mlc5PTR6IN88US=> NEPqSYNUSU6JRWK=
HT55 NID6cGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nmXWlEPTB;ND64OFU1PSEQvF2= Mn63V2FPT0WU
SK-N-FI M2rkS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTRwOEWwNFkh|ryP MkjxV2FPT0WU
ES1 NFrCb29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;uSY1KUUN3ME20Mlg3ODV5IN88US=> NI\Re29USU6JRWK=
SF126 M3fhWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTMTWM2OD12LkmzNVg1KM7:TR?= MmLtV2FPT0WU
ES5 NWOyTHhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjoZZdHUUN3ME21MlEzPDJ5IN88US=> NHPvTVVUSU6JRWK=
LoVo M4rWZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXT1XIxzUUN3ME21MlE2QDdzIN88US=> MkXkV2FPT0WU
SNU-387 M4XpNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDrSHpDUUN3ME21MlMzOzN7IN88US=> MkDEV2FPT0WU
C8166 NVHueGI6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\iTWM2OD13LkO2N|M6KM7:TR?= M3XCUnNCVkeHUh?=
LS-1034 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljMTWM2OD13LkSyN|A4KM7:TR?= NX7UXYU4W0GQR1XS
GR-ST NU\kPJRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nIe2lEPTB;NT61NlIxOSEQvF2= MmfDV2FPT0WU
NCI-H1092 NYXVUWpwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHGTVNkUUN3ME21MlczQDR|IN88US=> NInLVm5USU6JRWK=
647-V NGPQdZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYf4O2xGUUN3ME21Mlc1PzB4IN88US=> M1nUTXNCVkeHUh?=
EW-13 M2TDeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnRdoJ[UUN3ME21Mlc3PjJ5IN88US=> MnPiV2FPT0WU
KGN MorCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3j0cGlEPTB;Nj6wPVkzOSEQvF2= NWHTflNvW0GQR1XS
D-423MG NInSeGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTZwNECyPFQh|ryP M{nSSXNCVkeHUh?=
ECC10 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XoTGlEPTB;Nz6xNFExOSEQvF2= MXrTRW5ITVJ?
TE-5 M{G0RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFOxXpBKSzVyPUeuOFEzQThizszN NHnSUWVUSU6JRWK=
P12-ICHIKAWA NXeyfHR2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmD6TWM2OD15LkS1OVI{KM7:TR?= NF;ZU5JUSU6JRWK=
NCI-H82 NWHNWWN5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTCSoJyUUN3ME23MlQ2PzBzIN88US=> MWDTRW5ITVJ?
NCI-H1993 NYnvN2RET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3T2SGlEPTB;Nz64N|A3OyEQvF2= MnexV2FPT0WU
RH-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\XS4trUUN3ME23Mlg2OjR2IN88US=> MmXVV2FPT0WU
SW948 Ml3hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnOTWM2OD15Lkm2NFQ6KM7:TR?= Mnm3V2FPT0WU
CAL-33 M3GzWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vFc2lEPTB;Nz65PVk{QCEQvF2= MnnTV2FPT0WU
U-266 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjw[ldKSzVyPUiuNVU4PzdizszN MmLJV2FPT0WU
CAL-72 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DWOGlEPTB;OD6yNFMzKM7:TR?= NVjRPGtYW0GQR1XS
SNU-423 NVmzR4p6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rKcmlEPTB;OT6zOlY3PiEQvF2= MW\TRW5ITVJ?
KG-1 M{GyeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XicWlEPTB;OT61PFQ2PiEQvF2= NVK4dWVQW0GQR1XS
HCC1395 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkG5TWM2OD17LkmyN|UzKM7:TR?= NVnWZ3g5W0GQR1XS
BE-13 MoHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnnfFVpUUN3ME2xNE45QDl{IN88US=> MlPHV2FPT0WU
MKN7 NUPV[YxiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrBdG5KSzVyPUGwMlk4PjVizszN NX;4W2J3W0GQR1XS
697 M{LQcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13V[2lEPTB;MUGuNVQ4OiEQvF2= NFjtRpRUSU6JRWK=
LU-135 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\3UpRKSzVyPUGxMlI{ODdizszN NUPt[VFWW0GQR1XS
ES7 NGDGTmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTFzLkOzNVMh|ryP NIrRS5VUSU6JRWK=
SK-HEP-1 MknUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTFzLke2OFYh|ryP M{\NbHNCVkeHUh?=
BEN NEG5R2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\1U3VrUUN3ME2xNU45PTFizszN NGHBeoRUSU6JRWK=
NCI-H1770 M3e3WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTF{LkGyOkDPxE1? M{XGeHNCVkeHUh?=
SW13 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M36xTmlEPTB;MUKuNVU1OSEQvF2= M3K2PXNCVkeHUh?=
MZ1-PC MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXGUphxUUN3ME2xNk42PDV{IN88US=> NFjVUGZUSU6JRWK=
Mo-T NV\USGplT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fuN2lEPTB;MUKuO|QzOSEQvF2= MmDSV2FPT0WU
HLE MnK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHCZ29KSzVyPUGyMlgzOTVizszN MmnXV2FPT0WU
RCC10RGB NGXHR2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXkTWM2OD1zMz62O|Eh|ryP NX;UTXZ5W0GQR1XS
COLO-320-HSR M4rLZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTF|LkezPFEh|ryP MWTTRW5ITVJ?
BHT-101 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\4PVBKSzVyPUGzMlg{PDVizszN NYn6V2FSW0GQR1XS
OCUB-M NVTMTmV4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTF2LkG2NFIh|ryP M2HQR3NCVkeHUh?=
MEG-01 M2niO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW[y[Gt1UUN3ME2xOE4{PzB6IN88US=> NFraVmtUSU6JRWK=
RS4-11 MnTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rNdGlEPTB;MUSuO|QzKM7:TR?= M1XUV3NCVkeHUh?=
MN-60 NV7hfY9QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrsdlZKSzVyPUG0Mlc5QTRizszN M3nMPHNCVkeHUh?=
NCI-H1304 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DmfWlEPTB;MUWuNFQzPSEQvF2= M2\5d3NCVkeHUh?=
Ramos-2G6-4C10 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTF3LkC1PFEh|ryP MlLOV2FPT0WU
NCI-H2342 NVPvfo1iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXnNIpKSzVyPUG1MlIxPDRizszN MXPTRW5ITVJ?
LAN-6 NF3UUWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml[zTWM2OD1zNT60OFE1KM7:TR?= MnfJV2FPT0WU
JVM-2 NFHWSmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzwToV1UUN3ME2xOU42PzR6IN88US=> MoW2V2FPT0WU
P30-OHK NGjlfWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;oTWM2OD1zNj6wOlE1KM7:TR?= NIfBS2hUSU6JRWK=
C-33-A MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37y[mlEPTB;MU[uOlIyPCEQvF2= MVHTRW5ITVJ?
RPMI-8866 NYXld5pFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrmO2pKSzVyPUG2Mlg1QTZizszN M3zNRnNCVkeHUh?=
NCI-H630 NIHlWpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTF4Lki1N|ch|ryP Mn:1V2FPT0WU
KYSE-140 NYHWO2hQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTF5LkKwNlgh|ryP MkPLV2FPT0WU
T84 M2DkNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEP4UYlKSzVyPUG4Mlg3QTVizszN NYHoR|JQW0GQR1XS
KU-19-19 M2[3SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTF6Lkm2NFgh|ryP MoTsV2FPT0WU
BALL-1 NX\1UIs2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHT2RWlKSzVyPUG5MlM{QTlizszN M37Kb3NCVkeHUh?=
Calu-6 NFvDbYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnBTWM2OD1zOT60PVIh|ryP NEjJfVBUSU6JRWK=
EGI-1 NGTa[m9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTF7LkW5PEDPxE1? MoPtV2FPT0WU
MFH-ino M3jyemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jKXWlEPTB;MUmuO|Q2PCEQvF2= M{fENnNCVkeHUh?=
GB-1 NEDDfnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPLT5pYUUN3ME2yNE4{PTN3IN88US=> M1LyR3NCVkeHUh?=
NCI-H1693 NH[5[oZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnHT4ZKSzVyPUKwMlY2ODVizszN MWLTRW5ITVJ?
SW1116 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TBOGlEPTB;MkCuPVM3OiEQvF2= NV;hdXZxW0GQR1XS
H-EMC-SS MknWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTJ{LkC0OUDPxE1? MkfSV2FPT0WU
D-502MG NVPMOY5yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInSbFlKSzVyPUKyMlgzPjFizszN NGHke4FUSU6JRWK=
IA-LM MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHjXXZKSzVyPUKzMlI1QTNizszN MYfTRW5ITVJ?
SW1463 NXvIUFJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\2W|drUUN3ME2yN{44QSEQvF2= NIfIOVNUSU6JRWK=
JAR MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTaTWM2OD1{ND6zNlk{KM7:TR?= Mlq2V2FPT0WU
HT M2\jNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzyT5g3UUN3ME2yOE41PzV|IN88US=> M{LmO3NCVkeHUh?=
LCLC-103H NWHkb5JqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHre5NKSzVyPUK0Mlg1PDlizszN NWfjO2M6W0GQR1XS
SNU-449 NF2yS2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTLTWM2OD1{ND64O|QyKM7:TR?= NYXveldoW0GQR1XS
KE-37 NGfHe5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PUPWlEPTB;MkWuNFkzQCEQvF2= MYfTRW5ITVJ?
NCI-H1623 NXv3dFRWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrXPXI4UUN3ME2yO{4yOzB|IN88US=> M3:wZXNCVkeHUh?=
MOLT-13 MmXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTJ5LkO1NVYh|ryP M1rIWnNCVkeHUh?=
COLO-741 MnuwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DIZWlEPTB;M{GuN|M{OyEQvF2= MVjTRW5ITVJ?
NB6 NXXHZpVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlS2TWM2OD1|Mj6yPFc3KM7:TR?= NGjUNXZUSU6JRWK=
MOLT-16 M4j0N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTN|LkCwOVUh|ryP M2K0c3NCVkeHUh?=
IST-MES1 NWi1XVNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MniwTWM2OD1|ND6wOVQyKM7:TR?= NH35cJdUSU6JRWK=
A4-Fuk Mk\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTN3LkC2OkDPxE1? MXXTRW5ITVJ?
CAL-85-1 NWHjZpUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{e5[WlEPTB;M{WuNlgyPyEQvF2= Ml3OV2FPT0WU
CCRF-CEM NUXhOXExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fBOWlEPTB;M{euNVU{PiEQvF2= MV3TRW5ITVJ?
HAL-01 NInWd3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV2wfHhIUUN3ME2zPE41QDh7IN88US=> MWrTRW5ITVJ?
HEL MlrsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXP4O5JwUUN3ME20N{4{PDB7IN88US=> MWjTRW5ITVJ?
EW-1 MnGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTR|LkS3Olgh|ryP MlrZV2FPT0WU
MDA-MB-231 NFy0bIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXzeHhKSzVyPUS1MlEyQTlizszN NH7sbJNUSU6JRWK=
ABC-1 NF;r[ZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTR4Lki1N|gh|ryP M{fh[HNCVkeHUh?=
NCI-H446 NY[xOJBuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTR6LkWwOVgh|ryP NUP6[GhbW0GQR1XS
MHH-PREB-1 MmPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPMeoM4UUN3ME20PU43ODB5IN88US=> MkX2V2FPT0WU
DOHH-2 M1TROGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DvNGlEPTB;NEmuOlY2PiEQvF2= M3v3cXNCVkeHUh?=
GCT M37ycGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\SO2lEPTB;NEmuOlk4PiEQvF2= NHzEOJlUSU6JRWK=

... Click to View More Cell Line Experimental Data
体内研究 17-AAG作用于携带3T3-src, B16或CT26移植瘤裸鼠，与Hsp90结合具有高亲和力，IC50为8-35 nM，而作用于正常组织时，IC50为200-600 nM。[1] 17-AAG按50 mg/kg左右剂量处理，引起AR, HER2, HER3, 和 Akt表达明显降低，降低达50%以上，这种作用存在剂量依赖性，结果导致雄激素依赖型 (CWR22)和非依赖型(CWR22R 和CWRSA6) 前列腺移植瘤生长受抑制，抑制率分别为67%, 80%和 68%。[2]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验：[1]
+ 展开

Hsp90结合实验:

纯化的Hsp90蛋白或过量表达HER-2的癌细胞(BT474, N87, SKOV3 和 SKBR3) 裂解物或BT474乳腺癌细胞溶于溶解buffer(20 mM HEPES, pH 7.3, 1 mM EDTA, 5 mM MgCl2, 100 mM KCl) ，与不同浓度17-AAG在4oC下温育30分钟，然后和生物素-GM链接的BioMag链霉亲和素磁珠在4oC下温育1小时。试管放置于磁架上,除去未结合的上清液。在溶解buffer中清洗三次磁珠，然后在SDS–PAGE 样本缓冲液中在95oC下加热5分钟。在SDS蛋白凝胶上进行样本分析,使用特点抗体进行Western Blotting。使用Bio-rad Fluor-S 多重图像测量Western Blot条带，计算抑制Hsp90与生物素-GM结合的百分数。测定IC50。
细胞实验：[1]
+ 展开
  • Cell lines: BT474, SKBR3, N87, SKOV3, MCF7, MDA468, Hs578T, Hs578Bst, A549, HT29, U87, SKMG3, HT1080, RPTEC, NDF, HMVEC, HMEC, HUVEC, 和 PBMC
  • Concentrations: 溶于DMSO, 终浓度为10 μM 左右
  • Incubation Time: 5天
  • Method: 细胞按每孔2000个接种在96孔板上，终培养体积为100 μL，培养24小时， 然后加入浓度不断增高的17-AAG，温育5天。使用 Celltiter 96 AQueous 非放射性细胞增殖检测试剂盒测定存活细胞数。测定IC50。
    (Only for Reference)
动物实验：[2]
+ 展开
  • Animal Models: 皮下注射雄激素依赖性CWR22移植瘤的雄性 nu/nu 无胸腺小鼠， 皮下注射雄激素非依赖性的CWR22R和CWRSA6移植瘤的雌性nu/nu 无胸腺小鼠。
  • Formulation: 溶于DMSO, 对照组用蛋磷脂(EPL)稀释
  • Dosages: 50 mg/kg 左右
  • Administration: 腹膜注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 100 mg/mL (170.73 mM)
Ethanol 5 mg/mL (8.53 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)：
5%DMSO+corn oil 		10mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 585.69
化学式

C31H43N3O8
CAS号 75747-14-7
稳定性 powder
in solvent
别名 CP127374,NSC-330507, KOS 953

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量：

总分子量：g/mol

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00577889 Completed Adenocarcinoma of the Pancreas|Recurrent Pancreatic Cancer|Stage IV Pancreatic Cancer National Cancer Institute (NCI) March 2008 Phase 2
NCT00546780 Completed Multiple Myeloma Bristol-Myers Squibb February 2008 Phase 3
NCT00093496 Completed Primary Peritoneal Cavity Cancer|Recurrent Ovarian Epithelial Cancer|Stage III Ovarian Epithelial Cancer|Stage IV Ovarian Epithelial Cancer National Cancer Institute (NCI) October 2007 Phase 2
NCT00514371 Completed Multiple Myeloma Bristol-Myers Squibb August 2007 Phase 2|Phase 3
NCT00779428 Completed Advanced Malignancies Bristol-Myers Squibb July 2006 Phase 2
NCT00773344 Completed Solid Tumors|Breast Cancer Bristol-Myers Squibb December 2005 Phase 1|Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1：

    What kind of subtypes does this compound inhibit? HSP90α or HSP90β ?

  • 回答：

    17-AAG can inhibit both HSP90α and HSP90β, but it is unclear how much are they affected respectively. You should note that Hsp90 derived from tumor cells has a 100-fold higher binding affinity for 17-AAG than that from normal cells according to this paper. http://www.nature.com.ezp-prod1.hul.harvard.edu/nature/journal/v425/n6956/full/nature01913.html

Selleck产品目录册

HSP (e.g. HSP90) Signaling Pathway Map

HSP (e.g. HSP90) Inhibitors with Unique Features

  • 选择性强的HSP90抑制剂

    NVP-BEP800 : HSP90β-selective, IC50=58 nM.

  • 活性最高的HSP90抑制剂

    KW-2478 : HSP90, IC50=3.8 nM.

  • 用于临床的HSP90抑制剂

    17-DMAG (Alvespimycin) HCl : Phase II for Kidney Cancer.

  • 最新的HSP90抑制剂

    XL888 : ATP-competitive inhibitor of HSP90 with IC50 of 24 nM.

相关HSP (e.g. HSP90)产品

  • PU-H71 New

    PU-H71是有效的选择性HSP90抑制剂，IC50为51 nM。

  • KNK437 New

    KNK437 是一种泛-HSP 抑制剂，其抑制诱导型HSPs，包括 HSP105，HSP72，和 HSP40的合成。

  • VER155008 New

    VER-155008是一种有效的Hsp70家族抑制剂，无细胞试验中对HSP70，HSC70，和 GRP78的IC50分别为0.5 μM，2.6 μM，和 2.6 μM，比作用于HSP90选择性高100多倍。

  • Luminespib (AUY-922, NVP-AUY922)

    Luminespib (AUY-922, NVP-AUY922)是一种高效的HSP90抑制剂，无细胞试验中作用于HSP90α/β的IC50为13 nM /21 nM，对HSP90家族成员GRP94和TRAP-1具有稍弱的作用，与任何小分子HSP90配体均可紧密结合。Phase 2。

  • Ganetespib (STA-9090)

    Ganetespib (STA-9090)是一种HSP90抑制剂，在OSA 8种细胞中IC50为4 nM，诱导OSA细胞凋亡，而不影响正常的成骨细胞；是STA-1474的活性代谢物。Phase 3。

  • Alvespimycin (17-DMAG) HCl

    Alvespimycin (17-DMAG) HCl是一种有效的HSP90抑制剂，无细胞试验中IC50为62 nM。 Phase 2。

    Features:17-DMAG是抗生素Geldanamycin 的合成衍生物，比现有抗生素具有较低的肝毒性，比相似衍生物17-AAG效果和有效性更强。

  • Geldanamycin

    Geldanamycin是一种天然的HSP90抑制剂，Kd为1.2 μM，特异性干扰糖皮质激素受体（GR）/HSP联合。

  • HSP990 (NVP-HSP990)

    NVP-HSP990（HSP990）是一种新型有效的选择性 HSP90抑制剂，对HSP90α/β的IC50分别为0.6 nM和0.8 nM。

  • Elesclomol (STA-4783)

    Elesclomol (STA-4783)是一种新型有效的oxidative stress诱导剂，在肿瘤细胞中引起促凋亡作用。Phase 3。

  • Onalespib (AT13387)

    Onalespib (AT13387)是一种有效的，选择性Hsp90抑制剂，在A375细胞中IC50为18 nM，具有长持续性抗肿瘤活性。Phase 2。

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID