Tanespimycin (17-AAG)

目录号：S1141 别名： CP127374,NSC-330507, KOS 953

Molecular Weight(MW): 585.69

Tanespimycin (17-AAG)是一种有效的HSP90抑制剂，无细胞试验中IC50为5 nM，作用于来自肿瘤细胞的HSP90比作用于来自正常细胞HSP90结合亲和力高100倍。Phase 2。

规格

价格

库存

购买数量

10mM (in 1mL DMSO)	RMB 1597.01	现货
25mg	RMB 1221.85	现货
100mg	RMB 3016.43	现货
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客户购买Selleck的此次产品后发表的文献20篇：

客户使用该产品的9个实验数据：

(A) Cell lines were seeded in 96-well plates and treated with 10 nM of 17-AAG for 72 h. Cell survival was analyzed using CellTiter-Glo. Both parental H3122 cells (red bar) and H3122 CR cells (blue bar) show sensitivity to 17-AAG. (B) Suppression of ALK signaling by 17-AAG in resistant H3122 CR cells. H3122 parental and resistant cells were exposed to increasing concentrations of 17-AAG for 6 h.

PNAS, 2011, 108: 7535-40. Tanespimycin (17-AAG) purchased from Selleck.

(A) Treatment of DIPG cells with an HSP90 inhibitor, 17-AAG, resulted in decreased invasion toward SVZ hNPC CM at high doses. (B) Cell viability of DIPG cells treated with increasing doses of 17-AAG, by the CellTiter-Glo assay.

Cell, 2017, 170(5):845-859.e19. Tanespimycin (17-AAG) purchased from Selleck.
SKBR3 cells were treated with FW-04-806 at 10, 20, 40 uM for 24 h; 17AAG was used as a positive control at 1 and 2 uM. Hsp70, Hsp90, and Cdc37 protein level were analyzed with western blotting using relevant antibodies.

Mol Cancer 2014 13, 150. Tanespimycin (17-AAG) purchased from Selleck.

Western blot analysis of immunoprecipitated Hsp90/BIP complexes in MOLT-4 (T-ALL) and RS4;11 (B-ALL) treated for 22 h with CX-4945 (5 μM) and bortezomib (2.5 nM) either alone or in combination. 500 μg of protein lysates were immunoprecipitated with anti-Hsp90 antibody. Relative Induction values (Rel.Ind.) were obtained by normalizing to Hsp90 bands density. 17-AAG: tanespimycin.

Oncotarget, 2015, 51: S659-S660. Tanespimycin (17-AAG) purchased from Selleck.
Co-IP analyses of direct interaction between HSP90 and HIF-1α in 17-AAG (5 μM)-treated HSCs using antibodies against HSP90, HIF-1α or IgG (n = 2).

Br J Pharmacol, 2017, 174(5):409-423. Tanespimycin (17-AAG) purchased from Selleck.

Treatment with an Hsp90 inhibitor results in a dose-dependent decrease in complex IV activity. A, because Hsp90 levels were reduced by 80%, in PINK1 null dopaminergic neuronal cells, the effects of specific inhibition of Hsp90 using 17-AAG were analyzed in wild-type neuronal cells. Both complex IV activity and Hsp60 levels were decreased significantly in 17-AAG-treated cells in a dose-dependent manner. B, in contrast, 17-AAG treatment did not affect expression of Hsp90 and LRPPRC.

J Biol Chem 2012 287, 44109-20. Tanespimycin (17-AAG) purchased from Selleck.
UPR modulators destabilize mSmoM2. NIH 3T3 cells expressing mSmoM2 protein were treated with HSP90 inhibitors 17-AAG (50 uM and 100 uM) and SNX-2112 (25 uM and 50 uM) and the proteasome inhibitor bortezomib (25 uM and 50 uM) for 4 h prior to lysis. DMSO was the vehicle control. Western blotting of whole-cell lysates revealed mSmoM2 protein to be destabilized in response to HSP-90 inhibitors but not in response to bortezomib. Tubulin was the loading control. CHOP results indicate ER stress.

Mol Cell Biol 2013 33(12), 2375-87. Tanespimycin (17-AAG) purchased from Selleck.

Hsp90 is up-regulated during aging. Whole-cell extracts were prepared from young (PD 20) and old (PD 40) HFSN1 cells. c HFSN1 cells (PD 40) were treated with different concentration of the Hsp90 inhibitor (17-AAG) and then re-incubated for 24 h. Whole-cell extracts were prepared and analyzed by western blot using the indicated antibodies.

Age 2013 35, 549-62. Tanespimycin (17-AAG) purchased from Selleck.
Four types of the colon cancer cells with indicated K-Ras phenotype were incubated with indicated concentration of 17-AAG for 24 h, which were then analyzed for protein expression by WB.

Oncotarget 2014 5, 4269-82. Tanespimycin (17-AAG) purchased from Selleck.

产品安全说明书

HSP (e.g. HSP90)抑制剂选择性比较

生物活性

产品描述

特性

17-AAG对正常细胞的毒性很小。

靶点

HSP90 ^[1]
(Cell-free assay)

5 nM

体外研究

17-AAG是格尔德霉素类似物, 但是与过量表达HER-2的癌细胞 (BT474, N87, SKOV3 和SKBR3)或BT474乳腺细胞衍生的Hsp90亲和力高100多倍，IC50为5-6 nM, 而作用于正常人类原代细胞时，IC50为400-943 nM, 因为肿瘤Hsp90 处于多伴复合体状态，具有高ATP酶活性，而正常细胞Hsp90 处于潜在未结合状态, 且直接与那些细胞中17-AAG毒性相关。^[1]17-AAG 引起HER2, HER3, Akt，突变和野生型雄激素受体(AR)降解，导致前列腺细胞如LNCaP, LAPC-4, DU-145,和PC-3中RB依赖的 G1 期生长停顿，IC50为25-45 nM。^[2]除了诱导改变野生型BCR-ABL的Ba/F3细胞凋亡, IC50为5.2 μM, 17-AAG还通过诱导野生型和突变型 BCR-ABL蛋白降解，而诱导改变抗 Imatinib Mesylate的 T315I和 E255K BCR-ABL突变型细胞生长，IC50分别为2.3 μM 和 1.0 μM。^[3]

Cell Data

Cell Lines	Assay Type	Activity Description	PMID
A549	MniyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnTjTWM2OD1yLkCwNFMxOyEQvF2=	MX7TRW5ITVJ?
IST-MEL1	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MknQTWM2OD1yLkCwNFQxPyEQvF2=	NVTpVYhWW0GQR1XS
NCI-SNU-1	M{WxTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVrJR\|UxRTBwMECyNFch\|ryP	NHm2dlVUSU6JRWK=
FADU	NV7kZmo6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MojVTWM2OD1yLkCwNlA6KM7:TR?=	NYLIUZVXW0GQR1XS
C32	NHn3Um1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUHJR\|UxRTBwMECzNFQh\|ryP	M3f5eXNCVkeHUh?=
D-566MG	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYTJR\|UxRTBwMECzPUDPxE1?	M1rMNXNCVkeHUh?=
LXF-289	NXLaeJdMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHH2SVFKSzVyPUCuNFA1OTlizszN	MlPVV2FPT0WU
HGC-27	NHX6UZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXLJR\|UxRTBwMEC1NUDPxE1?	MVvTRW5ITVJ?
RPMI-7951	MmPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnfOTWM2OD1yLkCwO\|E4KM7:TR?=	MmnDV2FPT0WU
HSC-3	MljES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3vxPWlEPTB;MD6wNFkzQSEQvF2=	MVfTRW5ITVJ?
MIA-PaCa-2	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NITsTplKSzVyPUCuNFExODlizszN	NUS2Rox{W0GQR1XS
KS-1	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUDzOI9ZUUN3ME2wMlAyOzV3IN88US=>	MoHQV2FPT0WU
CAL-51	Mm\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGnhc3RKSzVyPUCuNFE1ODVizszN	MUPTRW5ITVJ?
MDA-MB-361	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVHyNIZOUUN3ME2wMlAyPDl3IN88US=>	M1LoWXNCVkeHUh?=
TI-73	NHfM[FdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWSxUVh3UUN3ME2wMlAyPzl4IN88US=>	NXHoOJZ3W0GQR1XS
AGS	NILiOJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlvYTWM2OD1yLkCxPVM5KM7:TR?=	NGmwdZlUSU6JRWK=
NCI-H460	NX3PSYJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYrJR\|UxRTBwMEG5O\|Qh\|ryP	MUDTRW5ITVJ?
A204	NXrZUo45T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVy2N2xuUUN3ME2wMlAzOjR7IN88US=>	MkLlV2FPT0WU
CHL-1	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmfpTWM2OD1yLkCyNlUyKM7:TR?=	MW\TRW5ITVJ?
DU-4475	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEX5fFNKSzVyPUCuNFIzPjFizszN	MVTTRW5ITVJ?
CGTH-W-1	NWPDWpN2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGDHWlFKSzVyPUCuNFI{PDlizszN	MkjVV2FPT0WU
HCC2218	MknIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlTtTWM2OD1yLkCyOFk1KM7:TR?=	NYLMVoZzW0GQR1XS
A2780	NVHPb3BjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4nyc2lEPTB;MD6wNlU{OSEQvF2=	MknjV2FPT0WU
NCI-H720	NWHlPGlVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWPJR\|UxRTBwMEK1OFYh\|ryP	M4DqUHNCVkeHUh?=
NCI-N87	M1jB[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlXLTWM2OD1yLkCyOVk{KM7:TR?=	MkHBV2FPT0WU
CHP-212	M2nMc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXvJR\|UxRTBwMEK2Nlgh\|ryP	MXLTRW5ITVJ?
NCI-H23	M1vuOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NX:5N4d{UUN3ME2wMlAzPjZ3IN88US=>	NVvvSVZ1W0GQR1XS
D-263MG	MljKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NInmPFNKSzVyPUCuNFI4QDZizszN	NG\rNIRUSU6JRWK=
ME-180	MlXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3LpPGlEPTB;MD6wNlg6OSEQvF2=	M{\tV3NCVkeHUh?=
SW982	NVrGeZJwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWPLe\|dkUUN3ME2wMlAzQTl7IN88US=>	M3HoVnNCVkeHUh?=
OE19	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NV30O3dSUUN3ME2wMlA{ODd5IN88US=>	MVXTRW5ITVJ?
SK-LU-1	Ml7hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4rBU2lEPTB;MD6wN\|A5OiEQvF2=	NWrrSoQ5W0GQR1XS
H4	MluxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NX;tb4RzUUN3ME2wMlA{ODlizszN	MY\TRW5ITVJ?
HT-144	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mnf3TWM2OD1yLkCzNFk{KM7:TR?=	NXq0XnY2W0GQR1XS
SK-UT-1	M3fwZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWTJR\|UxRTBwMEOxO\|gh\|ryP	NIXhbVBUSU6JRWK=
D-336MG	M{C2bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEfLVoxKSzVyPUCuNFM{ODlizszN	NWLpUJdjW0GQR1XS
MDA-MB-175-VII	NYnXZVM{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MV\JR\|UxRTBwMEOzOVQh\|ryP	M3jqUnNCVkeHUh?=
GAMG	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWXJR\|UxRTBwMEO0N\|Uh\|ryP	M{TJOnNCVkeHUh?=
CP50-MEL-B	Mn7IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnLnTWM2OD1yLkCzOFUh\|ryP	NV;rOXJtW0GQR1XS
OVCAR-5	NVf3SWxWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGPmPFRKSzVyPUCuNFM1QCEQvF2=	MYXTRW5ITVJ?
SK-MES-1	Mo\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUfyOW9wUUN3ME2wMlA{PjB4IN88US=>	MV;TRW5ITVJ?
VM-CUB-1	MnvKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MonRTWM2OD1yLkCzOlU4KM7:TR?=	NWfFcW52W0GQR1XS
WM-115	M2Dlc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXLsO2NOUUN3ME2wMlA{PzZ{IN88US=>	NW\6Rm9uW0GQR1XS
DSH1	NVnTZWtIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mn[xTWM2OD1yLkCzPFA4KM7:TR?=	NEHt[nNUSU6JRWK=
Becker	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NH;aZ5hKSzVyPUCuNFM5QDVizszN	MVnTRW5ITVJ?
SW962	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFjOTVdKSzVyPUCuNFM6PDVizszN	MUTTRW5ITVJ?
TYK-nu	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUHxPFFmUUN3ME2wMlA{QTh3IN88US=>	NVfGU2xvW0GQR1XS
HO-1-N-1	NULEeW9UT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXXyUVh3UUN3ME2wMlA1ODJzIN88US=>	MYrTRW5ITVJ?
T98G	M{TwO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mmm3TWM2OD1yLkC0NVA{KM7:TR?=	NYXSXm1KW0GQR1XS
ACN	NIDIboNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NV;FT3FGUUN3ME2wMlA1OTZ{IN88US=>	NEH3V5BUSU6JRWK=
SW780	NYrle4MzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYTJR\|UxRTBwMESyNFMh\|ryP	MoC2V2FPT0WU
Detroit562	NXT3U\|dRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHPQUWZKSzVyPUCuNFQzOzlizszN	MVzTRW5ITVJ?
BB49-HNC	NIrRfIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHfKNmNKSzVyPUCuNFQzPDNizszN	MV\TRW5ITVJ?
HN	M4ry[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWLJR\|UxRTBwMESyO\|Ih\|ryP	NUWwSlZvW0GQR1XS
H9	NYq5NW04T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlPCTWM2OD1yLkC0N\|cyKM7:TR?=	NVHMRpJPW0GQR1XS
VA-ES-BJ	M{TENmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1H5Z2lEPTB;MD6wOFQ1PyEQvF2=	M3LPS3NCVkeHUh?=
MEL-JUSO	NFW2UmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHrGd5JKSzVyPUCuNFQ1PzVizszN	MWPTRW5ITVJ?
BT-474	Mm\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{XPNGlEPTB;MD6wOFUh\|ryP	NEW4Zo5USU6JRWK=
CaR-1	NW\rVmtlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVXJR\|UxRTBwMES1OFkh\|ryP	MX\TRW5ITVJ?
PSN1	M3\PT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MW\JR\|UxRTBwMES2NFMh\|ryP	M2\DUnNCVkeHUh?=
KYSE-510	M1nqPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmTTTWM2OD1yLkC0OlQ6KM7:TR?=	MkT6V2FPT0WU
KP-4	NEDtdVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVPRRm82UUN3ME2wMlA1PzV\|IN88US=>	M{DLU3NCVkeHUh?=
KYSE-410	NH7RUplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkX4TWM2OD1yLkC0O\|czKM7:TR?=	Mn\NV2FPT0WU
G-402	NGnNVHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUjJR\|UxRTBwMES3PFkh\|ryP	NV;sdZVNW0GQR1XS
DOK	NWHaU5R4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVT3OYpNUUN3ME2wMlA1QTB{IN88US=>	NF;nOFdUSU6JRWK=
COR-L88	NXiyTGwxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlPETWM2OD1yLkC0PVEzKM7:TR?=	MoS3V2FPT0WU
SKG-IIIa	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYPJR\|UxRTBwMES5PFYh\|ryP	M36wXHNCVkeHUh?=
AN3-CA	MnW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkC3TWM2OD1yLkC1JO69VQ>?	MnrBV2FPT0WU
SW48	NE\QXm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIfsXIVKSzVyPUCuNFUxOzlizszN	MU\TRW5ITVJ?
YKG-1	M{\WNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmjJTWM2OD1yLkC1NFcyKM7:TR?=	NYe3U3MzW0GQR1XS
KYSE-150	MmfWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGTjVHpKSzVyPUCuNFUzOzVizszN	M2\JZXNCVkeHUh?=
HuO-3N1	M1H6XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1m0eGlEPTB;MD6wOVI{PyEQvF2=	NF;tdJRUSU6JRWK=
LB1047-RCC	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYnJR\|UxRTBwMEWyPVYh\|ryP	NFf4O5hUSU6JRWK=
NCI-H2030	MkT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkezTWM2OD1yLkC1OFE1KM7:TR?=	NWTPTIc1W0GQR1XS
YH-13	NGjveo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkGxTWM2OD1yLkC1O\|IzKM7:TR?=	MojNV2FPT0WU
5637	NIHaeo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV;JR\|UxRTBwMEW3OEDPxE1?	M3HGbXNCVkeHUh?=
LOXIMVI	NGDhV3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVrJR\|UxRTBwMEW4O\|Ih\|ryP	MWfTRW5ITVJ?
GT3TKB	M1vPdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NF;1V2lKSzVyPUCuNFU6PDJizszN	MVvTRW5ITVJ?
TCCSUP	M{XhOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWXXbpZCUUN3ME2wMlA2QTZ2IN88US=>	NXXhSYFJW0GQR1XS
EPLC-272H	NWWz[JdST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2XDWGlEPTB;MD6wOlIxPSEQvF2=	NX\aO5ZvW0GQR1XS
LU-99A	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUDJR\|UxRTBwME[yN\|ch\|ryP	MXrTRW5ITVJ?
NCI-H1755	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXXJR\|UxRTBwME[zOFEh\|ryP	NFHGWXFUSU6JRWK=
KM12	Moq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVHEe\|RTUUN3ME2wMlA3OzR6IN88US=>	NH\oPWtUSU6JRWK=
SF295	NXq0W41kT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUjJR\|UxRTBwME[0OVIh\|ryP	MoTIV2FPT0WU
MZ2-MEL	NIDYR2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2fZ[2lEPTB;MD6wOlU2OyEQvF2=	MnPUV2FPT0WU
HEC-1	NUDtXVJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmKyTWM2OD1yLkC2OVg5KM7:TR?=	NH\qUGFUSU6JRWK=
SW684	NFXxNVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlHLTWM2OD1yLkC2OVkyKM7:TR?=	Mk\OV2FPT0WU
SF539	MofES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFXLXnFKSzVyPUCuNFY3QDFizszN	M1zEcnNCVkeHUh?=
GMS-10	M2HF[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NH3Ic2JKSzVyPUCuNFY3QTlizszN	NYKzZYhoW0GQR1XS
MV-4-11	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXLJR\|UxRTBwME[4NFMh\|ryP	NEficoZUSU6JRWK=
HT-29	M3HlVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYflVHd2UUN3ME2wMlA3QTF7IN88US=>	NES4fGtUSU6JRWK=
23132-87	NYn2dHdFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXvjdZpOUUN3ME2wMlA3QTVizszN	MX7TRW5ITVJ?
SW620	Ml\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWm1SZhnUUN3ME2wMlA4ODJ4IN88US=>	M2XSVnNCVkeHUh?=
HCC1806	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUDJR\|UxRTBwMEexN\|Eh\|ryP	M1z0T3NCVkeHUh?=
Hs-578-T	M2fyNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NF7IZVdKSzVyPUCuNFczODhizszN	NYDMfoVVW0GQR1XS
A2058	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2HFU2lEPTB;MD6wO\|IzQCEQvF2=	NYnrZ3gyW0GQR1XS
MEL-HO	MlG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3H3SWlEPTB;MD6wO\|I2PSEQvF2=	M4DTfHNCVkeHUh?=
HCC2998	M1zVT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGHXPVBKSzVyPUCuNFc{PDdizszN	NEfTN4ZUSU6JRWK=
HuO9	M2\hbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3:2NmlEPTB;MD6wO\|U5QSEQvF2=	M4X6RnNCVkeHUh?=
CAL-39	M3vXUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIO3d4FKSzVyPUCuNFc4PjZizszN	MmDBV2FPT0WU
M14	NWHyOIxUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYjJR\|UxRTBwMEe5NVMh\|ryP	NV62W4JxW0GQR1XS
BFTC-909	Ml;PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWrpfXA3UUN3ME2wMlA4QTZ7IN88US=>	MoH5V2FPT0WU
TE-11	NEnEeXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{LufmlEPTB;MD6wO\|k6PiEQvF2=	M3TVXnNCVkeHUh?=
TGBC1TKB	MoPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmG4TWM2OD1yLkC4NFQ{KM7:TR?=	M3\ic3NCVkeHUh?=
L-363	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEDzN5JKSzVyPUCuNFgzODZizszN	NI\1flNUSU6JRWK=
A431	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWq1SpE3UUN3ME2wMlA5OjFizszN	NFrIV4xUSU6JRWK=
MKN45	M1vFOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmrxTWM2OD1yLkC4NlE6KM7:TR?=	MmLTV2FPT0WU
HT-1080	M{nIeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoW4TWM2OD1yLkC4OFM6KM7:TR?=	NIHaWHJUSU6JRWK=
OVCAR-8	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUHpXIpHUUN3ME2wMlA5PjJ{IN88US=>	MlLSV2FPT0WU
LCLC-97TM1	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFT3UodKSzVyPUCuNFg4OjhizszN	M{ju[XNCVkeHUh?=
M059J	MkLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHTxWIVKSzVyPUCuNFkxOjdizszN	M3y4R3NCVkeHUh?=
SK-MEL-2	M4LVSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFHFeJdKSzVyPUCuNFkxPiEQvF2=	Mo\qV2FPT0WU
TE-1	NX61TJpYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnjMTWM2OD1yLkC5NlA1KM7:TR?=	MlnzV2FPT0WU
KYSE-180	NGDp[GdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{nqcmlEPTB;MD6wPVI3OiEQvF2=	MkfrV2FPT0WU
D-247MG	MoHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYHJR\|UxRTBwMEm0OVUh\|ryP	M{PXR3NCVkeHUh?=
8-MG-BA	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2Po[mlEPTB;MD6wPVQ4OiEQvF2=	NYDFV4NNW0GQR1XS
NCI-H1792	M2jjXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVfTWHJVUUN3ME2wMlA6PjF6IN88US=>	NV7pd4pQW0GQR1XS
MCF7	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlfDTWM2OD1yLkC5Olc4KM7:TR?=	NHnx[ZJUSU6JRWK=
NCI-H2122	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NW[2OpJiUUN3ME2wMlA6PzR3IN88US=>	NULaSHBqW0GQR1XS
EFO-27	NXrORpUzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVvJR\|UxRTBwMEm5PVch\|ryP	NGf5PYtUSU6JRWK=
LB2241-RCC	NGT3WZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYfJR\|UxRTBwMUCwOVQh\|ryP	NYrPbnFyW0GQR1XS
SN12C	NIS4Ro5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlnLTWM2OD1yLkGwNVA4KM7:TR?=	NY[zT21xW0GQR1XS
A498	MlfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWPzUYdPUUN3ME2wMlExOThizszN	MoXZV2FPT0WU
PANC-03-27	M37QdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NY\3TI9mUUN3ME2wMlExOjh4IN88US=>	MkjrV2FPT0WU
NCI-H1581	NVf4SYpbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3PWPWlEPTB;MD6xNFI6KM7:TR?=	MnXLV2FPT0WU
U-87-MG	NUDjVmxDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWPvVmhZUUN3ME2wMlExOzB5IN88US=>	NX2yTFVZW0GQR1XS
G-401	NGDy[HlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnzhTWM2OD1yLkGwN\|U{KM7:TR?=	MUDTRW5ITVJ?
SiHa	M3vGSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mk\3TWM2OD1yLkGwOFg3KM7:TR?=	Ml3EV2FPT0WU
U251	M13kN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3O4S2lEPTB;MD6xNFUzPSEQvF2=	NH6zW4ZUSU6JRWK=
MMAC-SF	MkPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVnJR\|UxRTBwMUC1N\|Eh\|ryP	NGX5ZVVUSU6JRWK=
BB65-RCC	NYK5[5lQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHnUXG1KSzVyPUCuNVA2PTRizszN	MnTKV2FPT0WU
NKM-1	MlXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoTxTWM2OD1yLkGwOlY3KM7:TR?=	Mmr6V2FPT0WU
HD-MY-Z	M4rD[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIjjOG5KSzVyPUCuNVA5PzNizszN	NYHHVmdTW0GQR1XS
TGBC11TKB	NEHxbIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3OwXmlEPTB;MD6xNFkxOyEQvF2=	MVLTRW5ITVJ?
COLO-679	NEKybXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MX;JR\|UxRTBwMUGyNVEh\|ryP	MkXsV2FPT0WU
TE-8	NV7uVZlvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnTtTWM2OD1yLkGxNlY1KM7:TR?=	MlrIV2FPT0WU
SK-MEL-28	MmfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIDKUVRKSzVyPUCuNVE{OjFizszN	NWiyPZNSW0GQR1XS
SH-4	M2nVR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoX0TWM2OD1yLkGxN\|U3KM7:TR?=	MYLTRW5ITVJ?
KALS-1	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1zaNmlEPTB;MD6xNVM6OyEQvF2=	NUnqN4o3W0GQR1XS
RKO	MkXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mn7MTWM2OD1yLkGxO\|Y1KM7:TR?=	M1vTVHNCVkeHUh?=
OMC-1	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1LkOmlEPTB;MD6xNVc6PyEQvF2=	MVXTRW5ITVJ?
BT-549	MmXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWjJR\|UxRTBwMUG3PVkh\|ryP	MnPvV2FPT0WU
NCI-H28	MkfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmnqTWM2OD1yLkGxPFE4KM7:TR?=	MUfTRW5ITVJ?
RXF393	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4LwdWlEPTB;MD6xNVk5OiEQvF2=	NX3T[HB6W0GQR1XS
COLO-829	NEn0eWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGHxeVRKSzVyPUCuNVIxODVizszN	M1;mbnNCVkeHUh?=
HMV-II	NH3LR2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3T1XmlEPTB;MD6xNlAzKM7:TR?=	NYOycY9DW0GQR1XS
SW1990	NF\HTWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2r2OmlEPTB;MD6xNlE2PyEQvF2=	MlPSV2FPT0WU
NCI-H1437	MorXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mo\rTWM2OD1yLkGyNVU4KM7:TR?=	NHrrZ3ZUSU6JRWK=
SNB75	NH7hUFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFX1WYVKSzVyPUCuNVIyPjlizszN	NHHX[HJUSU6JRWK=
EW-3	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mmj0TWM2OD1yLkGyOlYyKM7:TR?=	MmDmV2FPT0WU
SAS	NFf4c3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWXRZZZPUUN3ME2wMlEzPjlizszN	MXTTRW5ITVJ?
NCI-H1666	NYnEdlR3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmOwTWM2OD1yLkGyO\|c1KM7:TR?=	M370TnNCVkeHUh?=
A375	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXzyOWVUUUN3ME2wMlEzPzd6IN88US=>	NFXneFZUSU6JRWK=
CAMA-1	NUiwcm9YT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mkn2TWM2OD1yLkGyPVI1KM7:TR?=	NH:4dnBUSU6JRWK=
HuP-T4	M1e5PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHjtR2JKSzVyPUCuNVI6PDNizszN	MmXOV2FPT0WU
NCI-H292	M4HXemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NF74ZW9KSzVyPUCuNVMyOSEQvF2=	Mlv4V2FPT0WU
PC-14	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUC0SnViUUN3ME2wMlE{OjFzIN88US=>	NXrWR4lzW0GQR1XS
BPH-1	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{nU[mlEPTB;MD6xN\|QyKM7:TR?=	M3HlbnNCVkeHUh?=
GAK	Ml\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXnJR\|UxRTBwMUO1Olch\|ryP	MV;TRW5ITVJ?
VMRC-RCZ	MkjmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIHsOm9KSzVyPUCuNVM4PjJizszN	NVjoeXBuW0GQR1XS
SK-MEL-24	NYnhOVB1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2PQ[2lEPTB;MD6xN\|g4KM7:TR?=	NEnWWnJUSU6JRWK=
LB831-BLC	NYHufotWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYXJR\|UxRTBwMUO4PFMh\|ryP	NXi3Wmo3W0GQR1XS
NCI-H2452	MlrGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUjJR\|UxRTBwMUO5OVYh\|ryP	M335b3NCVkeHUh?=
RT-112	MkTVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoXmTWM2OD1yLkG0NFM2KM7:TR?=	Mmn4V2FPT0WU
GP5d	NGO0eJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYDJR\|UxRTBwMUSxNFQh\|ryP	NWWwdWFWW0GQR1XS
LC-2-ad	NUjMb2RxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVjJR\|UxRTBwMUSxNlEh\|ryP	NH3WZ2hUSU6JRWK=
MPP-89	NXLDTGxQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmXwTWM2OD1yLkG0NVI2KM7:TR?=	M4TJcHNCVkeHUh?=
NUGC-3	Mm\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnvGTWM2OD1yLkG0OFc5KM7:TR?=	MYTTRW5ITVJ?
GI-1	NF\tXHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4C5VGlEPTB;MD6xOFU2QCEQvF2=	Ml7oV2FPT0WU
HCC1419	NFzVSllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYKxV2dwUUN3ME2wMlE1PTd4IN88US=>	NIfZZZZUSU6JRWK=
SW1573	MlzxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mm\qTWM2OD1yLkG0O\|U5KM7:TR?=	NFvJVmlUSU6JRWK=
NCI-H2347	NEjn[G5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWm5d\|VbUUN3ME2wMlE1QDN7IN88US=>	NWLWeItWW0GQR1XS
Mewo	NW\QUXBiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmTPTWM2OD1yLkG0PFg6KM7:TR?=	NVLzTmNJW0GQR1XS
639-V	NGjGS5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWTJNI1YUUN3ME2wMlE2ODF\|IN88US=>	M33jNHNCVkeHUh?=
AsPC-1	NImzeI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M37wTGlEPTB;MD6xOVIzPSEQvF2=	MUfTRW5ITVJ?
NCI-H1648	MkfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUHJWZk5UUN3ME2wMlE2OjN{IN88US=>	NETqSWtUSU6JRWK=
786-0	M{XZOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NILZeoZKSzVyPUCuNVU{QDFizszN	NH\sUmtUSU6JRWK=
ETK-1	M1Pje2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NE\DeGZKSzVyPUCuNVU6KM7:TR?=	Mk\oV2FPT0WU
BxPC-3	NIDxSGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnjOTWM2OD1yLkG1PVY3KM7:TR?=	MXTTRW5ITVJ?
CAL-62	NHfQcmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mn:5TWM2OD1yLkG2NVY6KM7:TR?=	MlHWV2FPT0WU
HCC1937	NWPje5gyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{f5ZmlEPTB;MD6xOlI4PSEQvF2=	M3z5fXNCVkeHUh?=
NCI-H1299	MkHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkLrTWM2OD1yLkG2Nlg2KM7:TR?=	M3fReHNCVkeHUh?=
SW1088	Ml:zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIPlbodKSzVyPUCuNVY1OTNizszN	MV7TRW5ITVJ?
FTC-133	NV3lOnpDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1;PW2lEPTB;MD6xOlU1KM7:TR?=	M3fh[nNCVkeHUh?=
OC-314	NH\KSXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3S0R2lEPTB;MD6xOlY6KM7:TR?=	NGHFcoNUSU6JRWK=
SCC-9	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4ryZmlEPTB;MD6xOlcyPiEQvF2=	NX;oPJp{W0GQR1XS
HT-1376	MkjUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWjZZ2ZNUUN3ME2wMlE3QTN4IN88US=>	M13rd3NCVkeHUh?=
U-2-OS	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1LZXmlEPTB;MD6xO\|E4OyEQvF2=	M4rKbXNCVkeHUh?=
COLO-824	NXLF[HpFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{Pzb2lEPTB;MD6xO\|I6PCEQvF2=	NIrlZVdUSU6JRWK=
BB30-HNC	MknKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1rFN2lEPTB;MD6xO\|M{KM7:TR?=	NU\TOGNKW0GQR1XS
NCI-H2087	NHG2TnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYKzTJpDUUN3ME2wMlE4OzZ6IN88US=>	NV70RWF5W0GQR1XS
NCI-H2170	MnqyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1vveWlEPTB;MD6xO\|U{PiEQvF2=	MXLTRW5ITVJ?
SK-OV-3	NFjEenFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWPFfIdsUUN3ME2wMlE4PTdzIN88US=>	NF[yWVBUSU6JRWK=
MZ7-mel	M{HMW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYPJR\|UxRTBwMUe2OFkh\|ryP	MomxV2FPT0WU
NCI-H650	M2\KRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MW\JR\|UxRTBwMUe2PFIh\|ryP	MYHTRW5ITVJ?
KOSC-2	MoPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mn7hTWM2OD1yLkG3O\|M1KM7:TR?=	NV:0cmV{W0GQR1XS
SCC-4	M4PjXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4n4VGlEPTB;MD6xO\|c4PyEQvF2=	M4rxfHNCVkeHUh?=
MDA-MB-157	MoXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlHoTWM2OD1yLkG4NFgzKM7:TR?=	NWDwZlg{W0GQR1XS
KYSE-520	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYmweFF[UUN3ME2wMlE5OiEQvF2=	NYjtS\|Z[W0GQR1XS
LK-2	M2j0UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUPJR\|UxRTBwMUizNFMh\|ryP	NH3MU\|JUSU6JRWK=
KNS-81-FD	M3T3SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIS3UGFKSzVyPUCuNVg{QTRizszN	NU\0T2x{W0GQR1XS
IGROV-1	M3;4NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3LvTGlEPTB;MD6xPFQ1OyEQvF2=	MorNV2FPT0WU
DEL	NVTRblBbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnfvTWM2OD1yLkG4OFUh\|ryP	M1\BbXNCVkeHUh?=
NCI-H1395	M1;2fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2D4O2lEPTB;MD6xPFY5OiEQvF2=	NFe1O\|JUSU6JRWK=
JEG-3	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MV\JR\|UxRTBwMUi3NFUh\|ryP	M3XvbHNCVkeHUh?=
BCPAP	M3XMOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NH:xNXNKSzVyPUCuNVg5PzJizszN	M1XNO3NCVkeHUh?=
CAL-27	MoXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2\VVGlEPTB;MD6xPVAzOiEQvF2=	M2fNb3NCVkeHUh?=
RD	NIOxZZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWjJR\|UxRTBwMUmxNVMh\|ryP	MmHoV2FPT0WU
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MSTO-211H	MoTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYHJR\|UxRTBwNUW3OlIh\|ryP	M1PrTnNCVkeHUh?=
NCI-H2126	MlruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHjpN41KSzVyPUCuOVY5OTVizszN	NVqzfIc{W0GQR1XS
SNU-C2B	NY\ydFNbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXHJR\|UxRTBwNUe5O\|ch\|ryP	MXHTRW5ITVJ?
DBTRG-05MG	NHP6T2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGPyRZZKSzVyPUCuOVgxPTNizszN	MVnTRW5ITVJ?
MKN1	NWf0enRIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXnVZ2NlUUN3ME2wMlU5Pzh\|IN88US=>	NGTS[I5USU6JRWK=
ES3	MmnqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NInMRnpKSzVyPUCuOVkyOjRizszN	NI[5XotUSU6JRWK=
OVCAR-3	NYexd2NWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHnac\|JKSzVyPUCuOVk{PDFizszN	NXjQ[pkzW0GQR1XS
ACHN	NH;ISZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXXGfWczUUN3ME2wMlYxPTZ7IN88US=>	MmTQV2FPT0WU
SW872	M32yO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NX7MVJZRUUN3ME2wMlYxPzZ\|IN88US=>	M1yyfXNCVkeHUh?=
CP66-MEL	NIXCTGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHW2WlhKSzVyPUCuOlA6PjlizszN	NFXMcI5USU6JRWK=
NCI-H661	NYXQ[\|JQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFjVPGRKSzVyPUCuOlEyODRizszN	MoHjV2FPT0WU
UACC-893	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1XKSGlEPTB;MD62N\|Y5OSEQvF2=	M1LYR3NCVkeHUh?=
JVM-3	NXXveHQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NG\BcWVKSzVyPUCuOlM5ODRizszN	NEThb\|hUSU6JRWK=
SF268	NXvtdIdYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWC5c45xUUN3ME2wMlY1OzR7IN88US=>	NF;l[ZpUSU6JRWK=
OCI-AML2	NEm1TIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUPJR\|UxRTBwNkWzPVch\|ryP	NVjZPXNkW0GQR1XS
RPMI-8226	NYHjN5JxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVztcFdQUUN3ME2wMlY3OzJ\|IN88US=>	M4\yR3NCVkeHUh?=
MKN28	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUDJR\|UxRTBwNk[2NlQh\|ryP	NWPUflhbW0GQR1XS
MDA-MB-453	MmWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVLJR\|UxRTBwNkexPEDPxE1?	M2P1UnNCVkeHUh?=
BV-173	NWD1ZlZyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkS1TWM2OD1yLk[4Olc6KM7:TR?=	NWe5Z4s6W0GQR1XS
NCI-H358	NIflWXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mm\YTWM2OD1yLk[4O\|I3KM7:TR?=	NWX1XotpW0GQR1XS
NCI-H1651	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVLJR\|UxRTBwNzFOwG0>	MnXXV2FPT0WU
MDA-MB-415	M4Dvfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1jRTWlEPTB;MD63NFgzQSEQvF2=	MXzTRW5ITVJ?
8305C	M3[zS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEHEdodKSzVyPUCuO\|I1QThizszN	NFOxOlhUSU6JRWK=
EFM-19	MlzxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnzNTWM2OD1yLkezOlcyKM7:TR?=	NIHpNpVUSU6JRWK=
RERF-LC-MS	NIfIXZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXm2UXU2UUN3ME2wMlc1PjF\|IN88US=>	NEnQSINUSU6JRWK=
A388	NYqzOnN4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEm3PW5KSzVyPUCuO\|Y1PjdizszN	MV\TRW5ITVJ?
GI-ME-N	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NH[2VFhKSzVyPUCuO\|czOzVizszN	MVnTRW5ITVJ?
IGR-1	NF\J[Y1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGTIPY5KSzVyPUCuO\|kxPDNizszN	M2Pmc3NCVkeHUh?=
LNCaP-Clone-FGC	M2rQXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mo\STWM2OD1yLkiwNFA1KM7:TR?=	M{T5XHNCVkeHUh?=
SK-MEL-3	NEXhNoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnXNTWM2OD1yLkixOVA5KM7:TR?=	MnThV2FPT0WU
UACC-257	M1nZNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NICzco9KSzVyPUCuPFIzOzFizszN	MlnyV2FPT0WU
OE33	NUfs[5Z{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUnWWVJSUUN3ME2wMlg2OTBzIN88US=>	M1ezRnNCVkeHUh?=
QIMR-WIL	NYrwbI43T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUfJR\|UxRTBwOEWxOFEh\|ryP	MYTTRW5ITVJ?
NCI-H2009	M3\kdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVzJR\|UxRTBwOEWzNVEh\|ryP	NEPESo1USU6JRWK=
NCI-H522	NVO3VoQzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVnJR\|UxRTBwOEe3PFMh\|ryP	NGfXR2ZUSU6JRWK=
Saos-2	M2roZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NV3TRYV2UUN3ME2wMlg4QDdzIN88US=>	MYDTRW5ITVJ?
NB17	NHnubYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnTlTWM2OD1yLki4NFI2KM7:TR?=	MoXMV2FPT0WU
D-392MG	NWW1dpZET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1;VRWlEPTB;MD64PVM2PiEQvF2=	NYDaUpNIW0GQR1XS
SHP-77	MkPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnywTWM2OD1yLkmwOFg2KM7:TR?=	NILFSmVUSU6JRWK=
SK-MEL-30	NGfRNXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVPvWJA1UUN3ME2wMlkyOTh3IN88US=>	MXjTRW5ITVJ?
GCIY	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1W0N2lEPTB;MD65NVg1OyEQvF2=	MnvXV2FPT0WU
HCC70	M4DlN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2O5N2lEPTB;MD65NlA2QSEQvF2=	NYXGcVhLW0GQR1XS
LU-65	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NF7rUohKSzVyPUCuPVI2QTFizszN	MVXTRW5ITVJ?
NCI-H1563	NGHkdWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mo\lTWM2OD1yLkm0PFY2KM7:TR?=	M4C5PHNCVkeHUh?=
KURAMOCHI	Mom3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NV73NWFuUUN3ME2wMlk2OTl{IN88US=>	NYXrc\|VRW0GQR1XS
PA-1	MlvBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHrTVHNKSzVyPUCuPVU1OjRizszN	NEjDbnhUSU6JRWK=
NOS-1	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmDQTWM2OD1yLkm3OFg6KM7:TR?=	MVHTRW5ITVJ?
NCI-H69	M2LzTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NX3PW4ZmUUN3ME2wMlk4PjN2IN88US=>	M4HscHNCVkeHUh?=
KYSE-450	NUG4TmNqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVXJR\|UxRTBwOUi2NlYh\|ryP	M1\2XXNCVkeHUh?=
8505C	MoGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NE\RT5JKSzVyPUCuPVk6QDJizszN	M3XwVnNCVkeHUh?=
TGBC24TKB	MmfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1nodWlEPTB;MT6wNFA5PCEQvF2=	M17POnNCVkeHUh?=
PFSK-1	MoD0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHTRUXJKSzVyPUGuNFE1OjhizszN	M4XTbnNCVkeHUh?=
EKVX	NYKz[5dDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYTGR21pUUN3ME2xMlA{OTJzIN88US=>	NI\2PW1USU6JRWK=
RCM-1	MmnKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NInhRmNKSzVyPUGuNFU2ODdizszN	MlHGV2FPT0WU
SW900	MknoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWHVN4syUUN3ME2xMlA4QDNizszN	NFjFZZBUSU6JRWK=
D-542MG	NVTiXWpOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUHJR\|UxRTFwMEe4OVUh\|ryP	M3\FenNCVkeHUh?=
SK-PN-DW	MoPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MW\JR\|UxRTFwMUCwOVYh\|ryP	MXjTRW5ITVJ?
NCI-H727	NGHDVmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NG\E[mVKSzVyPUGuNVAyPTRizszN	MlfBV2FPT0WU
SW837	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlPwTWM2OD1zLkGwPVU1KM7:TR?=	M{\BPHNCVkeHUh?=
BT-20	NYHiRZFFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mk\kTWM2OD1zLkGxNlA1KM7:TR?=	NWrFXo84W0GQR1XS
RH-18	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVHJR\|UxRTFwMUOxNFMh\|ryP	MYfTRW5ITVJ?
TE-12	MkP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnniTWM2OD1zLkGzN\|M{KM7:TR?=	MXzTRW5ITVJ?
NB10	Mlq1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NH3CR\|VKSzVyPUGuNVM{PDRizszN	MY\TRW5ITVJ?
AU565	M3;CTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFPOcmRKSzVyPUGuNVU6PzNizszN	M3i0[XNCVkeHUh?=
OAW-42	NYDCS4ZFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWjUW3B5UUN3ME2xMlE5OzB4IN88US=>	NFfqV41USU6JRWK=
DJM-1	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYLLe4FRUUN3ME2xMlE6QDhzIN88US=>	MVnTRW5ITVJ?
HH	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2DRTWlEPTB;MT6yN\|g{OSEQvF2=	M4\wXnNCVkeHUh?=
LAMA-84	MonzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXrRcnJLUUN3ME2xMlI4Ozl2IN88US=>	M3TxPHNCVkeHUh?=
KNS-42	M1XGZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWPJR\|UxRTFwM{CyPVYh\|ryP	MYjTRW5ITVJ?
NCI-H2052	MmDGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MW\JR\|UxRTFwM{C1NFch\|ryP	NImwTHlUSU6JRWK=
MLMA	M4HrcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mnf1TWM2OD1zLkOyOFA4KM7:TR?=	MoTVV2FPT0WU
NB12	NYLIPYJST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVLJR\|UxRTFwM{W2N\|Yh\|ryP	MkTwV2FPT0WU
NCI-H1838	NYLJbJBOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGP3[pdKSzVyPUGuN\|Y{ODZizszN	NHPMN\|JUSU6JRWK=
NCI-H526	MoLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmryTWM2OD1zLkO3PFU{KM7:TR?=	MUfTRW5ITVJ?
LS-123	NGjVfG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NULQcVN7UUN3ME2xMlM6ODl2IN88US=>	MoTuV2FPT0WU
HDLM-2	Mk\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NH\zN25KSzVyPUGuN\|kzPzFizszN	NFXZT2pUSU6JRWK=
MC-IXC	M{LzNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mnu3TWM2OD1zLkSyN\|cyKM7:TR?=	NYfuVIFyW0GQR1XS
HCT-15	NUnHblVsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MULJR\|UxRTFwNEOwOlgh\|ryP	NHzS[WJUSU6JRWK=
NCI-H596	MkP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnvWTWM2OD1zLkS1NFYyKM7:TR?=	MlTVV2FPT0WU
ZR-75-30	MoW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYXJR\|UxRTFwNEewPFIh\|ryP	MWLTRW5ITVJ?
A704	NH\aTJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXTJR\|UxRTFwNk[1OlMh\|ryP	NGryVY5USU6JRWK=
OVCAR-4	NGPBTnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlnYTWM2OD1zLk[5OlA4KM7:TR?=	MV7TRW5ITVJ?
SW1417	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUHJR\|UxRTFwN{K4OFkh\|ryP	MoPUV2FPT0WU
CAS-1	M2fncWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYXJR\|UxRTFwN{O5N\|Yh\|ryP	NFK1R2NUSU6JRWK=
IST-SL1	NHvUUFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFS3SJBKSzVyPUGuO\|k4PTlizszN	MkTqV2FPT0WU
A253	NH24bmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYX3fpBnUUN3ME2xMlgzOjN7IN88US=>	MXvTRW5ITVJ?
EW-16	NXjQOo9JT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUjJR\|UxRTFwOEK4O\|Uh\|ryP	NGX1[oFUSU6JRWK=
SK-NEP-1	NWm5N\|kxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEHSPVhKSzVyPUGuPFY6QDhizszN	NWK2[Hh5W0GQR1XS
NCI-H226	NYr0OVRxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NELB[WhKSzVyPUGuPFk{PTlizszN	MXfTRW5ITVJ?
HOP-92	NVPa[YdtT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXzJR\|UxRTFwOU[wPVkh\|ryP	MkDPV2FPT0WU
NCI-H441	NVnhTpQxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVu3S5U2UUN3ME2yMlAzOzN5IN88US=>	NH;mS21USU6JRWK=
LU-139	NVf4UZdYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYDKOlNlUUN3ME2yMlA{OTF2IN88US=>	NVzlW4xMW0GQR1XS
SJRH30	Ml3vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1zhNGlEPTB;Mj6wOFI2OyEQvF2=	MXPTRW5ITVJ?
MG-63	NUD3RmJyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{nRNWlEPTB;Mj6xOFEyOSEQvF2=	Ml;CV2FPT0WU
NH-12	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVPYN3B4UUN3ME2yMlE2ODB4IN88US=>	MVzTRW5ITVJ?
NB7	NE\0PG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{OzVmlEPTB;Mj6xPVY4OyEQvF2=	MkTVV2FPT0WU
LB771-HNC	NXTUemhNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnPlTWM2OD1{LkKwOVk2KM7:TR?=	MUDTRW5ITVJ?
HCC1569	M3vFV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGjJWnhKSzVyPUKuNlQ2QDNizszN	MXjTRW5ITVJ?
D-283MED	NWnXPIV3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkT0TWM2OD1{LkK0O\|gzKM7:TR?=	NFjrb5lUSU6JRWK=
J-RT3-T3-5	MkfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mm[0TWM2OD1{LkK1N\|UyKM7:TR?=	MmPmV2FPT0WU
ATN-1	NXGxfIFIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYC4N4JxUUN3ME2yMlM{ODh{IN88US=>	MX\TRW5ITVJ?
HCC1954	NV\uZWV[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M161V2lEPTB;Mj6zOFQxQCEQvF2=	MmjEV2FPT0WU
SCC-15	NFTzNFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV7JR\|UxRTJwM{mzNVIh\|ryP	M4jiXnNCVkeHUh?=
COLO-668	MnGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoGxTWM2OD1{LkSzNkDPxE1?	MYLTRW5ITVJ?
LB373-MEL-D	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGXTbHRKSzVyPUKuOVQ3PzdizszN	M4fpdHNCVkeHUh?=
no-10	M2H2dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUTNT41lUUN3ME2yMlU1QTR5IN88US=>	MnHjV2FPT0WU
HT-1197	NHv3dW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWHDRXBCUUN3ME2yMlY{OTh6IN88US=>	NVzYXWpOW0GQR1XS
DU-145	M4m2RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXXVTIhWUUN3ME2yMlc6OTZ{IN88US=>	M{LnU3NCVkeHUh?=
SK-N-AS	NVm4V3N7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVnJR\|UxRTJwOES2PVIh\|ryP	MXvTRW5ITVJ?
MOLT-4	NXztVVFDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEPUfmJKSzVyPUKuPFU{OjJizszN	M1fYVnNCVkeHUh?=
EW-22	NXX0UmY{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXKzcZRWUUN3ME2yMlkzQDRzIN88US=>	M4PKWnNCVkeHUh?=
DB	M1LXT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mor0TWM2OD1{Lkm3O\|U6KM7:TR?=	M4\NTXNCVkeHUh?=
HL-60	M3LrUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NX\hSZFoUUN3ME2zMlA1Ozd4IN88US=>	NF;sU\|hUSU6JRWK=
SK-N-DZ	MmTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2\semlEPTB;Mz6wOVA4PSEQvF2=	NYHkOYVrW0GQR1XS
NY	M4PxUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnL1TWM2OD1\|LkC4OVQzKM7:TR?=	MmjNV2FPT0WU
T47D	NVyyOmpOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MV;JR\|UxRTNwMUC1OVgh\|ryP	M1LqO3NCVkeHUh?=
NCI-H2029	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3LBWGlEPTB;Mz6yNlQ4PyEQvF2=	M{DSNXNCVkeHUh?=
KARPAS-299	NXj4U2d6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUXifG9LUUN3ME2zMlI3ODJ5IN88US=>	NFjhXohUSU6JRWK=
KM-H2	NVzIclVuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NX;LOYVvUUN3ME2zMlMxPjhizszN	MVvTRW5ITVJ?
CHP-134	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NF\nSolKSzVyPUOuOFc{QSEQvF2=	M3naOnNCVkeHUh?=
22RV1	M2HCNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIHBbmpKSzVyPUOuOFkyPjhizszN	M3LDb3NCVkeHUh?=
NB5	M4fDcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M37PSWlEPTB;Mz61NFY5QSEQvF2=	NXrtZ44yW0GQR1XS
CW-2	NEX5PW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3XyTGlEPTB;Mz61OVMyPCEQvF2=	MWXTRW5ITVJ?
EFO-21	M3y3OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUjwNJpiUUN3ME2zMlU3QTRizszN	NHf4[HFUSU6JRWK=
HuH-7	NY[2ZlZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MV7JR\|UxRTNwNUi0NVQh\|ryP	NW\V[G9SW0GQR1XS
ALL-PO	NF3i[IJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXThXJFpUUN3ME2zMlYzOzN3IN88US=>	MWfTRW5ITVJ?
EM-2	M3\VOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYXJR\|UxRTNwNkmwNVEh\|ryP	MXzTRW5ITVJ?
KLE	NF;oPXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NX;HcVAxUUN3ME2zMlc{ODJ7IN88US=>	NITweGlUSU6JRWK=
NEC8	MmTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NH:1eIpKSzVyPUOuPVE5ODhizszN	NUDUe2t7W0GQR1XS
KP-N-YN	NVP1fnJLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHH0b2RKSzVyPUOuPVM1PzZizszN	M{TLW3NCVkeHUh?=
SK-MEL-1	Ml;OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXnJVFk{UUN3ME20MlA{PTF6IN88US=>	M{LDfnNCVkeHUh?=
CAL-54	NGXNRZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVHmVmlVUUN3ME20MlA2QTFizszN	MVPTRW5ITVJ?
MS-1	NU\BO49qT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFjkVZlKSzVyPUSuNVYyPTVizszN	M{jyN3NCVkeHUh?=
NCI-H209	NH;oOGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYHDe205UUN3ME20MlI6QTl7IN88US=>	NGjOSGlUSU6JRWK=
NOMO-1	M{fhcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2T6VWlEPTB;ND6zNlE{OSEQvF2=	NVfXXWJEW0GQR1XS
RPMI-2650	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXrJR\|UxRTRwM{[zNlch\|ryP	M1LOTHNCVkeHUh?=
NCI-H810	M3XEb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlXnTWM2OD12LkO5O\|M3KM7:TR?=	NX\WRo9SW0GQR1XS
Ca9-22	NEXFN4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1ewPGlEPTB;ND60OVY6OSEQvF2=	M{Dj[nNCVkeHUh?=
ES4	NF3lRoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHr4eIJKSzVyPUSuOFcxQTVizszN	NIjvbmFUSU6JRWK=
ES6	NV7ib4xRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkLwTWM2OD12LkS5OlU4KM7:TR?=	MmWzV2FPT0WU
DMS-114	NH;ie5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUHJR\|UxRTRwNUS2PVEh\|ryP	MY\TRW5ITVJ?
ONS-76	MmXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVK4XXdUUUN3ME20MlU4QTVizszN	NWfweXZTW0GQR1XS
K-562	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYLGVXdiUUN3ME20Mlc{QDF2IN88US=>	NELEPIlUSU6JRWK=
MHH-NB-11	M4f5RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVm0VZJGUUN3ME20Mlc2PDZzIN88US=>	M3XqVXNCVkeHUh?=
Calu-3	M1nu[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYqzb2Y2UUN3ME20Mlc5PTR6IN88US=>	MXvTRW5ITVJ?
HT55	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWfJR\|UxRTRwOES1OFUh\|ryP	NVnKVnFQW0GQR1XS
SK-N-FI	NIfnUZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV7JR\|UxRTRwOEWwNFkh\|ryP	M3;i[XNCVkeHUh?=
ES1	NFja[mNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFjtdVlKSzVyPUSuPFYxPTdizszN	MlHrV2FPT0WU
SF126	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3KxXmlEPTB;ND65N\|E5PCEQvF2=	M37aW3NCVkeHUh?=
ES5	NYj5c2h2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkHjTWM2OD13LkGyOFI4KM7:TR?=	M1m3WnNCVkeHUh?=
LoVo	NYX6W5M5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MoHOTWM2OD13LkG1PFcyKM7:TR?=	M2T2ZXNCVkeHUh?=
SNU-387	NY\QeG1ET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEHtPWhKSzVyPUWuN\|I{OzlizszN	NVXUSmRuW0GQR1XS
C8166	NIXpXIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4G5VGlEPTB;NT6zOlM{QSEQvF2=	MlzlV2FPT0WU
LS-1034	NHfvRm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGnoc5pKSzVyPUWuOFI{ODdizszN	M1XvXnNCVkeHUh?=
GR-ST	MlvrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2DCdWlEPTB;NT61NlIxOSEQvF2=	MYfTRW5ITVJ?
NCI-H1092	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NX;CcnY{UUN3ME21MlczQDR\|IN88US=>	MXfTRW5ITVJ?
647-V	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWOxdY8zUUN3ME21Mlc1PzB4IN88US=>	M4XKe3NCVkeHUh?=
EW-13	M1j6VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXvJR\|UxRTVwN{[2Nlch\|ryP	NXHNNYdZW0GQR1XS
KGN	NFLOXHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUTJR\|UxRTZwMEm5NlEh\|ryP	MXHTRW5ITVJ?
D-423MG	MoK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoTJTWM2OD14LkSwNlg1KM7:TR?=	NX\sVnA6W0GQR1XS
ECC10	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MoTjTWM2OD15LkGwNVAyKM7:TR?=	NU\y[nFMW0GQR1XS
TE-5	NXfuO3lGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4i1UWlEPTB;Nz60NVI6QCEQvF2=	MUPTRW5ITVJ?
P12-ICHIKAWA	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mo\NTWM2OD15LkS1OVI{KM7:TR?=	M4W3dnNCVkeHUh?=
NCI-H82	NWX5fmRET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFvLcY5KSzVyPUeuOFU4ODFizszN	NI\oVYRUSU6JRWK=
NCI-H1993	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1KyNGlEPTB;Nz64N\|A3OyEQvF2=	Mme2V2FPT0WU
RH-1	NVHBTGdiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NF\DVHdKSzVyPUeuPFUzPDRizszN	MYTTRW5ITVJ?
SW948	Mn;4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NETVSpZKSzVyPUeuPVYxPDlizszN	MV7TRW5ITVJ?
CAL-33	Mn;jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mn7tTWM2OD15Lkm5PVM5KM7:TR?=	NYXtem1sW0GQR1XS
U-266	NEfHfYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFLDe3BKSzVyPUiuNVU4PzdizszN	MmfwV2FPT0WU
CAL-72	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmXrTWM2OD16LkKwN\|Ih\|ryP	MUjTRW5ITVJ?
SNU-423	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnH6TWM2OD17LkO2OlY3KM7:TR?=	MUjTRW5ITVJ?
KG-1	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUjJR\|UxRTlwNUi0OVYh\|ryP	NFTPdGtUSU6JRWK=
HCC1395	NEC5RWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXXJR\|UxRTlwOUKzOVIh\|ryP	Mm\GV2FPT0WU
BE-13	MlG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mm\5TWM2OD1zMD64PFkzKM7:TR?=	M33CUnNCVkeHUh?=
MKN7	NVPDVWl6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXf1XmM6UUN3ME2xNE46PzZ3IN88US=>	MV\TRW5ITVJ?
697	NH6xNmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUTWOYJNUUN3ME2xNU4yPDd{IN88US=>	MV;TRW5ITVJ?
LU-135	M4HodGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYjJR\|UxRTFzLkKzNFch\|ryP	MVLTRW5ITVJ?
ES7	NXvwVoFkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUHJR\|UxRTFzLkOzNVMh\|ryP	NXy4ZZFKW0GQR1XS
SK-HEP-1	M1HiXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUm5NoVjUUN3ME2xNU44PjR4IN88US=>	MY\TRW5ITVJ?
BEN	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFrwSmJKSzVyPUGxMlg2OSEQvF2=	NVHWXYx4W0GQR1XS
NCI-H1770	M4i3dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWe0NItCUUN3ME2xNk4yOjZizszN	NHGxUoJUSU6JRWK=
SW13	NELWbGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NV;TNVQ{UUN3ME2xNk4yPTRzIN88US=>	NHHMeZBUSU6JRWK=
MZ1-PC	MmjaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1y2OGlEPTB;MUKuOVQ2OiEQvF2=	NUi4UYl[W0GQR1XS
Mo-T	NFyzOplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkHPTWM2OD1zMj63OFIyKM7:TR?=	MX7TRW5ITVJ?
HLE	MnXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M33TV2lEPTB;MUKuPFIyPSEQvF2=	MYDTRW5ITVJ?
RCC10RGB	Mn3LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGHMR2FKSzVyPUGzMlY4OSEQvF2=	MUnTRW5ITVJ?
COLO-320-HSR	NHvwZVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MorNTWM2OD1zMz63N\|gyKM7:TR?=	MYTTRW5ITVJ?
BHT-101	NGq4XXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXfJR\|UxRTF\|LkizOFUh\|ryP	MlHhV2FPT0WU
OCUB-M	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4PSOGlEPTB;MUSuNVYxOiEQvF2=	MXPTRW5ITVJ?
MEG-01	MlXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmrGTWM2OD1zND6zO\|A5KM7:TR?=	M2X5NnNCVkeHUh?=
RS4-11	M{LrV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVTJR\|UxRTF2Lke0NkDPxE1?	NXr2N4JzW0GQR1XS
MN-60	MnjCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWnJR\|UxRTF2Lke4PVQh\|ryP	MoLvV2FPT0WU
NCI-H1304	Ml3DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mkf6TWM2OD1zNT6wOFI2KM7:TR?=	M3rFS3NCVkeHUh?=
Ramos-2G6-4C10	NVjDbVE3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYXJR\|UxRTF3LkC1PFEh\|ryP	MXLTRW5ITVJ?
NCI-H2342	MmXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnHlTWM2OD1zNT6yNFQ1KM7:TR?=	NHnLZYlUSU6JRWK=
LAN-6	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWLocJJDUUN3ME2xOU41PDF2IN88US=>	M2rjOHNCVkeHUh?=
JVM-2	NEHOW3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVXjXJVSUUN3ME2xOU42PzR6IN88US=>	M3TkR3NCVkeHUh?=
P30-OHK	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFW0XY9KSzVyPUG2MlA3OTRizszN	M17WPXNCVkeHUh?=
C-33-A	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUf2T45UUUN3ME2xOk43OjF2IN88US=>	NGXWTmFUSU6JRWK=
RPMI-8866	MlP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUnJR\|UxRTF4Lki0PVYh\|ryP	M4XxcnNCVkeHUh?=
NCI-H630	NGTN[mVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmHiTWM2OD1zNj64OVM4KM7:TR?=	MWrTRW5ITVJ?
KYSE-140	NVHR[nhzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4rYemlEPTB;MUeuNlAzQCEQvF2=	MorNV2FPT0WU
T84	NYf4T5JGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{i0bGlEPTB;MUiuPFY6PSEQvF2=	NX;Cd216W0GQR1XS
KU-19-19	M1\mfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIe2T2tKSzVyPUG4Mlk3ODhizszN	MljDV2FPT0WU
BALL-1	NFSzcpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFnuV2FKSzVyPUG5MlM{QTlizszN	M{LjZnNCVkeHUh?=
Calu-6	NHjyXm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXjwW\|NSUUN3ME2xPU41QTJizszN	Moi5V2FPT0WU
EGI-1	NGm4NFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NX7YZ3NKUUN3ME2xPU42QThizszN	M4DERnNCVkeHUh?=
MFH-ino	MojNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlHETWM2OD1zOT63OFU1KM7:TR?=	M4m0NXNCVkeHUh?=
GB-1	MmO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYnSXYJWUUN3ME2yNE4{PTN3IN88US=>	M3vKTXNCVkeHUh?=
NCI-H1693	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXrLOW14UUN3ME2yNE43PTB3IN88US=>	M4X6[nNCVkeHUh?=
SW1116	MljCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NETObHNKSzVyPUKwMlk{PjJizszN	MmTKV2FPT0WU
H-EMC-SS	NFfNZYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NILQR\|lKSzVyPUKyMlA1PSEQvF2=	NUHlV4pZW0GQR1XS
D-502MG	NHXKcGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHP0fmRKSzVyPUKyMlgzPjFizszN	NVrCVIp7W0GQR1XS
IA-LM	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWLJR\|UxRTJ\|LkK0PVMh\|ryP	MlP1V2FPT0WU
SW1463	M2jZ[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXf3VlkzUUN3ME2yN{44QSEQvF2=	NHrESWdUSU6JRWK=
JAR	MnziS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlrUTWM2OD1{ND6zNlk{KM7:TR?=	NUDpe3c4W0GQR1XS
HT	NFLzOmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVvGfYhPUUN3ME2yOE41PzV\|IN88US=>	NEC2UlVUSU6JRWK=
LCLC-103H	NGDPSo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlW4TWM2OD1{ND64OFQ6KM7:TR?=	M4juUHNCVkeHUh?=
SNU-449	M4nnPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUfJR\|UxRTJ2Lki3OFEh\|ryP	M1jwNXNCVkeHUh?=
KE-37	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1freWlEPTB;MkWuNFkzQCEQvF2=	M{S2cHNCVkeHUh?=
NCI-H1623	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NETlc4lKSzVyPUK3MlE{ODNizszN	NWTzfFRIW0GQR1XS
MOLT-13	MnewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIq5V3VKSzVyPUK3MlM2OTZizszN	M2\rU3NCVkeHUh?=
COLO-741	NGTTSXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFjhN\|lKSzVyPUOxMlM{OzNizszN	MX;TRW5ITVJ?
NB6	M1fue2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGTJSHJKSzVyPUOyMlI5PzZizszN	NE\YbVlUSU6JRWK=
MOLT-16	M2\RUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MknpTWM2OD1\|Mz6wNFU2KM7:TR?=	NIXZWo5USU6JRWK=
IST-MES1	NEDZNWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXrJR\|UxRTN2LkC1OFEh\|ryP	M333VHNCVkeHUh?=
A4-Fuk	M3nZSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFP3T4VKSzVyPUO1MlA3PiEQvF2=	M3;xZnNCVkeHUh?=
CAL-85-1	M2PrNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYrsW41SUUN3ME2zOU4zQDF5IN88US=>	MnvuV2FPT0WU
CCRF-CEM	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWDJR\|UxRTN5LkG1N\|Yh\|ryP	NVLNW4lbW0GQR1XS
HAL-01	M1ixfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2nkZWlEPTB;M{iuOFg5QSEQvF2=	NVmxW\|lzW0GQR1XS
HEL	NHi2eG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{e5R2lEPTB;NEOuN\|QxQSEQvF2=	M13jTHNCVkeHUh?=
EW-1	NYHXRnJXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIG5WZlKSzVyPUSzMlQ4PjhizszN	NHzHcI1USU6JRWK=
MDA-MB-231	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUnVWpVxUUN3ME20OU4yOTl7IN88US=>	MmG1V2FPT0WU
ABC-1	NVz6eHF{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFfKSYpKSzVyPUS2Mlg2OzhizszN	NF3UVZFUSU6JRWK=
NCI-H446	NETucmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2f1eGlEPTB;NEiuOVA2QCEQvF2=	NFvqdlJUSU6JRWK=
MHH-PREB-1	MkTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlTDTWM2OD12OT62NFA4KM7:TR?=	MofRV2FPT0WU
DOHH-2	Mlq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWHJR\|UxRTR7Lk[2OVYh\|ryP	Mlu3V2FPT0WU
GCT	M2fnXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFrjNpZKSzVyPUS5MlY6PzZizszN	NYfqRlFQW0GQR1XS

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体内研究

17-AAG作用于携带3T3-src, B16或CT26移植瘤裸鼠，与Hsp90结合具有高亲和力，IC50为8-35 nM，而作用于正常组织时，IC50为200-600 nM。^[1] 17-AAG按50 mg/kg左右剂量处理，引起AR, HER2, HER3, 和 Akt表达明显降低，降低达50%以上，这种作用存在剂量依赖性，结果导致雄激素依赖型 (CWR22)和非依赖型(CWR22R 和CWRSA6) 前列腺移植瘤生长受抑制，抑制率分别为67%, 80%和 68%。^[2]

激酶实验：^[1]	+ 展开 Hsp90结合实验: 纯化的Hsp90蛋白或过量表达HER-2的癌细胞(BT474, N87, SKOV3 和 SKBR3) 裂解物或BT474乳腺癌细胞溶于溶解buffer(20 mM HEPES, pH 7.3, 1 mM EDTA, 5 mM MgCl₂, 100 mM KCl) ，与不同浓度17-AAG在4^oC下温育30分钟，然后和生物素-GM链接的BioMag链霉亲和素磁珠在4^oC下温育1小时。试管放置于磁架上,除去未结合的上清液。在溶解buffer中清洗三次磁珠，然后在SDS–PAGE 样本缓冲液中在95^oC下加热5分钟。在SDS蛋白凝胶上进行样本分析,使用特点抗体进行Western Blotting。使用Bio-rad Fluor-S 多重图像测量Western Blot条带，计算抑制Hsp90与生物素-GM结合的百分数。测定IC50。
细胞实验：^[1]	+ 展开 Cell lines: BT474, SKBR3, N87, SKOV3, MCF7, MDA468, Hs578T, Hs578Bst, A549, HT29, U87, SKMG3, HT1080, RPTEC, NDF, HMVEC, HMEC, HUVEC, 和 PBMC Concentrations: 溶于DMSO, 终浓度为10 μM 左右 Incubation Time: 5天 Method: 细胞按每孔2000个接种在96孔板上，终培养体积为100 μL，培养24小时，然后加入浓度不断增高的17-AAG，温育5天。使用 Celltiter 96 AQueous 非放射性细胞增殖检测试剂盒测定存活细胞数。测定IC50。 (Only for Reference)
动物实验：^[2]	+ 展开 Animal Models: 皮下注射雄激素依赖性CWR22移植瘤的雄性 nu/nu 无胸腺小鼠，皮下注射雄激素非依赖性的CWR22R和CWRSA6移植瘤的雌性nu/nu 无胸腺小鼠。 Formulation: 溶于DMSO, 对照组用蛋磷脂(EPL)稀释 Dosages: 50 mg/kg 左右 Administration: 腹膜注射 (Only for Reference)

参考文献

溶解度 (25°C)

体外	DMSO	100 mg/mL (170.73 mM)
	Ethanol	5 mg/mL (8.53 mM)
	Water	Insoluble
体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： 5%DMSO+corn oil	10mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download Tanespimycin (17-AAG) SDF

分子量	585.69
化学式	C₃₁H₄₃N₃O₈
CAS号	75747-14-7
稳定性	3 years -20°C powder
稳定性	2 years -80°C in solvent
别名	CP127374,NSC-330507, KOS 953

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

临床试验信息 (data from https://clinicaltrials.gov, updated on 2018-11-16)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT00577889	Completed	Adenocarcinoma of the Pancreas\|Recurrent Pancreatic Cancer\|Stage IV Pancreatic Cancer	National Cancer Institute (NCI)	March 2008	Phase 2
NCT00546780	Completed	Multiple Myeloma	Bristol-Myers Squibb	February 2008	Phase 3
NCT00093496	Completed	Primary Peritoneal Cavity Cancer\|Recurrent Ovarian Epithelial Cancer\|Stage III Ovarian Epithelial Cancer\|Stage IV Ovarian Epithelial Cancer	National Cancer Institute (NCI)	October 2007	Phase 2
NCT00514371	Completed	Multiple Myeloma	Bristol-Myers Squibb	August 2007	Phase 2\|Phase 3
NCT00779428	Completed	Advanced Malignancies	Bristol-Myers Squibb	July 2006	Phase 2
NCT00354185	Terminated	Adult Nasal Type Extranodal NK/T-cell Lymphoma\|Anaplastic Large Cell Lymphoma\|Angioimmunoblastic T-cell Lymphoma\|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue\|Intraocular Lymphoma\|Nodal Marginal Zone B-cell Lymphoma\|Post-transplant Lymphoproliferative Disorder\|Recurrent Adult Burkitt Lymphoma\|Recurrent Adult Diffuse Large Cell Lymphoma\|Recurrent Adult Diffuse Mixed Cell Lymphoma\|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma\|Recurrent Adult Grade III Lymphomatoid Granulomatosis\|Recurrent Adult Hodgkin Lymphoma\|Recurrent Adult Immunoblastic Large Cell Lymphoma\|Recurrent Adult Lymphoblastic Lymphoma\|Recurrent Adult T-cell Leukemia/Lymphoma\|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma\|Recurrent Grade 1 Follicular Lymphoma\|Recurrent Grade 2 Follicular Lymphoma\|Recurrent Grade 3 Follicular Lymphoma\|Recurrent Mantle Cell Lymphoma\|Recurrent Marginal Zone Lymphoma\|Recurrent Mycosis Fungoides/Sezary Syndrome\|Recurrent Small Lymphocytic Lymphoma\|Small Intestine Lymphoma\|Splenic Marginal Zone Lymphoma\|Stage III Adult Burkitt Lymphoma\|Stage III Adult Diffuse Large Cell Lymphoma\|Stage III Adult Diffuse Mixed Cell Lymphoma\|Stage III Adult Diffuse Small Cleaved Cell Lymphoma\|Stage III Adult Hodgkin Lymphoma\|Stage III Adult Immunoblastic Large Cell Lymphoma\|Stage III Adult Lymphoblastic Lymphoma\|Stage III Adult T-cell Leukemia/Lymphoma\|Stage III Cutaneous T-cell Non-Hodgkin Lymphoma\|Stage III Grade 1 Follicular Lymphoma\|Stage III Grade 2 Follicular Lymphoma\|Stage III Grade 3 Follicular Lymphoma\|Stage III Mantle Cell Lymphoma\|Stage III Marginal Zone Lymphoma\|Stage III Mycosis Fungoides/Sezary Syndrome\|Stage III Small Lymphocytic Lymphoma\|Stage IV Adult Burkitt Lymphoma\|Stage IV Adult Diffuse Large Cell Lymphoma\|Stage IV Adult Diffuse Mixed Cell Lymphoma\|Stage IV Adult Diffuse Small Cleaved Cell Lymphoma\|Stage IV Adult Hodgkin Lymphoma\|Stage IV Adult Immunoblastic Large Cell Lymphoma\|Stage IV Adult Lymphoblastic Lymphoma\|Stage IV Adult T-cell Leukemia/Lymphoma\|Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma\|Stage IV Grade 1 Follicular Lymphoma\|Stage IV Grade 2 Follicular Lymphoma\|Stage IV Grade 3 Follicular Lymphoma\|Stage IV Mantle Cell Lymphoma\|Stage IV Marginal Zone Lymphoma\|Stage IV Mycosis Fungoides/Sezary Syndrome\|Stage IV Small Lymphocytic Lymphoma\|Unspecified Adult Solid Tumor Protocol Specific\|Waldenström Macroglobulinemia	National Cancer Institute (NCI)	May 2006	Phase 1

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

常见问题及建议解决方法

问题 1：
What kind of subtypes does this compound inhibit? HSP90α or HSP90β ?
回答：
17-AAG can inhibit both HSP90α and HSP90β, but it is unclear how much are they affected respectively. You should note that Hsp90 derived from tumor cells has a 100-fold higher binding affinity for 17-AAG than that from normal cells according to this paper. http://www.nature.com.ezp-prod1.hul.harvard.edu/nature/journal/v425/n6956/full/nature01913.html

HSP (e.g. HSP90) Signaling Pathway Map

HSP (e.g. HSP90) Inhibitors with Unique Features

选择性强的HSP90抑制剂

NVP-BEP800 : HSP90β-selective, IC50=58 nM.
活性最高的HSP90抑制剂

KW-2478 : HSP90, IC50=3.8 nM.
用于临床的HSP90抑制剂

17-DMAG (Alvespimycin) HCl : Phase II for Kidney Cancer.
最新的HSP90抑制剂

XL888 : ATP-competitive inhibitor of HSP90 with IC50 of 24 nM.

研究领域

产品类型

Tanespimycin (17-AAG)

客户购买Selleck的此次产品后发表的文献20篇：

客户使用该产品的9个实验数据：

产品安全说明书

HSP (e.g. HSP90)抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download Tanespimycin (17-AAG) SDF

计算器

摩尔浓度计算器

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

临床试验信息 (data from https://clinicaltrials.gov, updated on 2018-11-16)

技术支持

常见问题及建议解决方法

HSP (e.g. HSP90) Signaling Pathway Map

HSP (e.g. HSP90) Inhibitors with Unique Features

相关HSP (e.g. HSP90)产品