Tanespimycin (17-AAG)

For research use only. Not for use in humans.

目录号:S1141 别名: CP127374,NSC-330507, KOS 953 中文名称:坦螺旋霉素

Tanespimycin (17-AAG) Chemical Structure

CAS No. 75747-14-7

Tanespimycin (17-AAG, CP127374, NSC-330507, KOS 953) 是一种有效的HSP90抑制剂,无细胞试验中IC50为5 nM,作用于来自肿瘤细胞的HSP90比作用于来自正常细胞HSP90结合亲和力高100倍。Tanespimycin (17-AAG)可诱导细胞凋亡、坏死、自噬和线粒体自噬。Phase 3。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 2350.91 现货
RMB 795.18 现货
RMB 2432.97 现货
RMB 6527.43 现货
RMB 10950.03 现货

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客户使用Selleck生产的Tanespimycin (17-AAG)发表文献81篇:

产品安全说明书

HSP (HSP90)抑制剂选择性比较

生物活性

产品描述 Tanespimycin (17-AAG, CP127374, NSC-330507, KOS 953) 是一种有效的HSP90抑制剂,无细胞试验中IC50为5 nM,作用于来自肿瘤细胞的HSP90比作用于来自正常细胞HSP90结合亲和力高100倍。Tanespimycin (17-AAG)可诱导细胞凋亡、坏死、自噬和线粒体自噬。Phase 3。
特性 17-AAG对正常细胞的毒性很小。
靶点
HSP90 [1]
(Cell-free assay)
5 nM
体外研究

17-AAG是格尔德霉素类似物, 但是与过量表达HER-2的癌细胞 (BT474, N87, SKOV3 和SKBR3)或BT474乳腺细胞衍生的Hsp90亲和力高100多倍,IC50为5-6 nM, 而作用于正常人类原代细胞时,IC50为400-943 nM, 因为肿瘤Hsp90 处于多伴复合体状态,具有高ATP酶活性,而正常细胞Hsp90 处于潜在未结合状态, 且直接与那些细胞中17-AAG毒性相关。[1]17-AAG 引起HER2, HER3, Akt,突变和野生型雄激素受体(AR)降解,导致前列腺细胞如LNCaP, LAPC-4, DU-145,和PC-3中RB依赖的 G1 期生长停顿,IC50为25-45 nM。[2]除了诱导改变野生型BCR-ABL的Ba/F3细胞凋亡, IC50为5.2 μM, 17-AAG还通过诱导野生型和突变型 BCR-ABL蛋白降解,而诱导改变抗 Imatinib Mesylate的 T315I和 E255K BCR-ABL突变型细胞生长,IC50分别为2.3 μM 和 1.0 μM。[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A549 M2TTT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVf2NW9DUUN3ME2wMlAxODNyMzFOwG0> NIjSNZlUSU6JRWK=
IST-MEL1 Mlj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjwUHdKSzVyPUCuNFAxPDB5IN88US=> M13xSnNCVkeHUh?=
NCI-SNU-1 NHSxeHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\YcGlEPTB;MD6wNFIxPyEQvF2= MorqV2FPT0WU
FADU MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTBwMECyNFkh|ryP M2izT3NCVkeHUh?=
C32 M4\xe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXKTWM2OD1yLkCwN|A1KM7:TR?= Moe5V2FPT0WU
D-566MG NH;Qb|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fuPGlEPTB;MD6wNFM6KM7:TR?= NWfVelFPW0GQR1XS
LXF-289 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3QeJR1UUN3ME2wMlAxPDF7IN88US=> M3LFS3NCVkeHUh?=
HGC-27 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2[wOWlEPTB;MD6wNFUyKM7:TR?= NEnNXmlUSU6JRWK=
RPMI-7951 NWnPcZpjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvIPGJKSzVyPUCuNFA4OTdizszN MXPTRW5ITVJ?
HSC-3 M4niRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;CS2lEPTB;MD6wNFkzQSEQvF2= MoTMV2FPT0WU
MIA-PaCa-2 MojGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwMEGwNFkh|ryP NFvMTINUSU6JRWK=
KS-1 M37uNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3mUpdSUUN3ME2wMlAyOzV3IN88US=> NV2xRVFIW0GQR1XS
CAL-51 NWi1d2piT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHKRnZKSzVyPUCuNFE1ODVizszN MWfTRW5ITVJ?
MDA-MB-361 M{j6Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDWTWM2OD1yLkCxOFk2KM7:TR?= MYDTRW5ITVJ?
TI-73 M3f3Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\sTWM2OD1yLkCxO|k3KM7:TR?= MVTTRW5ITVJ?
AGS MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwMEG5N|gh|ryP MlvVV2FPT0WU
NCI-H460 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXroVoo4UUN3ME2wMlAyQTd2IN88US=> M{jnS3NCVkeHUh?=
A204 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvBdm1KSzVyPUCuNFIzPDlizszN NYHZRXpDW0GQR1XS
CHL-1 M4foc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\WTmlEPTB;MD6wNlI2OSEQvF2= MVrTRW5ITVJ?
DU-4475 NIXQO4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPITWM2OD1yLkCyNlYyKM7:TR?= M1vRNXNCVkeHUh?=
CGTH-W-1 MojSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vrNGlEPTB;MD6wNlM1QSEQvF2= NUjCRVhXW0GQR1XS
HCC2218 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;oTWM2OD1yLkCyOFk1KM7:TR?= M2jHbnNCVkeHUh?=
A2780 NVPicZRDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjoeXk1UUN3ME2wMlAzPTNzIN88US=> MkHCV2FPT0WU
NCI-H720 Mn;6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVm1WYhxUUN3ME2wMlAzPTR4IN88US=> NUPBSoRiW0GQR1XS
NCI-N87 Mo\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXCTFhKSzVyPUCuNFI2QTNizszN M33VZ3NCVkeHUh?=
CHP-212 NV;zWFF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHNN|hKSzVyPUCuNFI3OjhizszN MkDDV2FPT0WU
NCI-H23 M{KxWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTBwMEK2OlUh|ryP NVy0e3JSW0GQR1XS
D-263MG MnrJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwMEK3PFYh|ryP MkfEV2FPT0WU
ME-180 NFezNnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHhenZKSzVyPUCuNFI5QTFizszN NFXpOmRUSU6JRWK=
SW982 Mn;kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTBwMEK5PVkh|ryP M3HvWXNCVkeHUh?=
OE19 NXLBZnRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTBwMEOwO|ch|ryP MWnTRW5ITVJ?
SK-LU-1 M3TUb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13kfmlEPTB;MD6wN|A5OiEQvF2= NIX0WWZUSU6JRWK=
H4 Mn33S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvRTWM2OD1yLkCzNFkh|ryP MVPTRW5ITVJ?
HT-144 MnzCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nyTGlEPTB;MD6wN|A6OyEQvF2= NYnkUGxnW0GQR1XS
SK-UT-1 MljYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojsTWM2OD1yLkCzNVc5KM7:TR?= MleyV2FPT0WU
D-336MG M1q1PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4W5b2lEPTB;MD6wN|MxQSEQvF2= M4Szb3NCVkeHUh?=
MDA-MB-175-VII M3\1emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLDTWM2OD1yLkCzN|U1KM7:TR?= M4[2eXNCVkeHUh?=
GAMG MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTBwMEO0N|Uh|ryP M1[xPHNCVkeHUh?=
CP50-MEL-B M4O0fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX23ZVlDUUN3ME2wMlA{PDVizszN MXzTRW5ITVJ?
OVCAR-5 NGHSdGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDR[VVKSzVyPUCuNFM1QCEQvF2= NEjsfYRUSU6JRWK=
SK-MES-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWD3eoJpUUN3ME2wMlA{PjB4IN88US=> MWfTRW5ITVJ?
VM-CUB-1 NUj6RnNiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\MRoFKSzVyPUCuNFM3PTdizszN MVjTRW5ITVJ?
WM-115 NFPkOJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTmTWM2OD1yLkCzO|YzKM7:TR?= NX3nR4V4W0GQR1XS
DSH1 M3XxWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4X5SGlEPTB;MD6wN|gxPyEQvF2= Ml3nV2FPT0WU
Becker NV;kSXA3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7h[WtKSzVyPUCuNFM5QDVizszN M1rLN3NCVkeHUh?=
SW962 NFHjTpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHjTWM2OD1yLkCzPVQ2KM7:TR?= MX3TRW5ITVJ?
TYK-nu NYDPW4s{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTBwMEO5PFUh|ryP NX3PVGxIW0GQR1XS
HO-1-N-1 NX7q[YxNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2OxdmlEPTB;MD6wOFAzOSEQvF2= M17oVXNCVkeHUh?=
T98G NW\1R5VGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwMESxNFMh|ryP NHKz[XVUSU6JRWK=
ACN NVzs[|NvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDHTWM2OD1yLkC0NVYzKM7:TR?= M1PnOXNCVkeHUh?=
SW780 NH;CfIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DRemlEPTB;MD6wOFIxOyEQvF2= NYnEc4JPW0GQR1XS
Detroit562 NF;zZm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mor4TWM2OD1yLkC0NlM6KM7:TR?= NUTUfY96W0GQR1XS
BB49-HNC NVeyfFNYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvJ[XRyUUN3ME2wMlA1OjR|IN88US=> M{L1UHNCVkeHUh?=
HN MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWixV5p3UUN3ME2wMlA1Ojd{IN88US=> NIfpbGtUSU6JRWK=
H9 MlvXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jhNWlEPTB;MD6wOFM4OSEQvF2= NUjNUW1MW0GQR1XS
VA-ES-BJ NX\rVJliT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLJbnVrUUN3ME2wMlA1PDR5IN88US=> M3LxTnNCVkeHUh?=
MEL-JUSO NUXXcotpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTBwMES0O|Uh|ryP NEDEUVRUSU6JRWK=
BT-474 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTBwMES1JO69VQ>? NVvTXm1QW0GQR1XS
CaR-1 M2rZemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fQVmlEPTB;MD6wOFU1QSEQvF2= Ml\TV2FPT0WU
PSN1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HwOWlEPTB;MD6wOFYxOyEQvF2= MUHTRW5ITVJ?
KYSE-510 M1;vRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPiTWM2OD1yLkC0OlQ6KM7:TR?= NHXDeoNUSU6JRWK=
KP-4 M4HCcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrubZdKSzVyPUCuNFQ4PTNizszN MkjLV2FPT0WU
KYSE-410 NH;kOJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHPTWM2OD1yLkC0O|czKM7:TR?= MXzTRW5ITVJ?
G-402 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwMES3PFkh|ryP NGjTXWxUSU6JRWK=
DOK MmTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTBwMES5NFIh|ryP Ml[4V2FPT0WU
COR-L88 MkTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknHTWM2OD1yLkC0PVEzKM7:TR?= NX7TSXhkW0GQR1XS
SKG-IIIa NVXIT3prT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVi5SWl[UUN3ME2wMlA1QTh4IN88US=> MXLTRW5ITVJ?
AN3-CA NUTXdlFyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInhNmNKSzVyPUCuNFUh|ryP NV2yWohkW0GQR1XS
SW48 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3j0dGlEPTB;MD6wOVA{QSEQvF2= MUPTRW5ITVJ?
YKG-1 MmjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NES0R2pKSzVyPUCuNFUxPzFizszN MVnTRW5ITVJ?
KYSE-150 NIXkOJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2O1ZmlEPTB;MD6wOVI{PSEQvF2= NGTQV41USU6JRWK=
HuO-3N1 NYXtZnBET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XMb2lEPTB;MD6wOVI{PyEQvF2= NWHadFVDW0GQR1XS
LB1047-RCC MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLUNHpKSzVyPUCuNFUzQTZizszN MWfTRW5ITVJ?
NCI-H2030 M2\1RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFOxbHdKSzVyPUCuNFU1OTRizszN M1TLUXNCVkeHUh?=
YH-13 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\W[2lEPTB;MD6wOVczOiEQvF2= NI\IRoNUSU6JRWK=
5637 NHLjNoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPHO2VKSzVyPUCuNFU4PCEQvF2= MXrTRW5ITVJ?
LOXIMVI M3G3dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUO2TJJlUUN3ME2wMlA2QDd{IN88US=> MYnTRW5ITVJ?
GT3TKB NHPxU5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF[4V4xKSzVyPUCuNFU6PDJizszN MV7TRW5ITVJ?
TCCSUP NFjEZ29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwMEW5OlQh|ryP MUTTRW5ITVJ?
EPLC-272H M3ntZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\VWGlEPTB;MD6wOlIxPSEQvF2= MnThV2FPT0WU
LU-99A NV\SRnR4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPnSnRKSzVyPUCuNFYzOzdizszN NWTy[2JpW0GQR1XS
NCI-H1755 NVf1PVg5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PC[WlEPTB;MD6wOlM1OSEQvF2= MWHTRW5ITVJ?
KM12 M4rUTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwME[zOFgh|ryP NV7GTnUyW0GQR1XS
SF295 MmS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvx[49kUUN3ME2wMlA3PDV{IN88US=> NXLnPYI5W0GQR1XS
MZ2-MEL NFPVUlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTBwME[1OVMh|ryP M2LrS3NCVkeHUh?=
HEC-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LFV2lEPTB;MD6wOlU5QCEQvF2= M{jr[nNCVkeHUh?=
SW684 NF7lbmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13SSmlEPTB;MD6wOlU6OSEQvF2= NUDVTnNLW0GQR1XS
SF539 NYDuXZRbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTBwME[2PFEh|ryP Mlj1V2FPT0WU
GMS-10 NXnnR4M5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwME[2PVkh|ryP NHy5WHhUSU6JRWK=
MV-4-11 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PkdGlEPTB;MD6wOlgxOyEQvF2= M3HRTXNCVkeHUh?=
HT-29 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnYeVhKSzVyPUCuNFY6OTlizszN NFO1dVZUSU6JRWK=
23132-87 M3rq[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHlTWM2OD1yLkC2PVUh|ryP NVLubFhbW0GQR1XS
SW620 M4m3SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwMEewNlYh|ryP NXmwcGxqW0GQR1XS
HCC1806 NVzlUW9ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrwTWM2OD1yLkC3NVMyKM7:TR?= MnXDV2FPT0WU
Hs-578-T MmrXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\z[mlEPTB;MD6wO|IxQCEQvF2= M3fQ[XNCVkeHUh?=
A2058 MmPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzkbWJ[UUN3ME2wMlA4OjJ6IN88US=> M3\McHNCVkeHUh?=
MEL-HO MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnSxTWM2OD1yLkC3NlU2KM7:TR?= M13udXNCVkeHUh?=
HCC2998 MlzwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTBwMEezOFch|ryP MlzQV2FPT0WU
HuO9 NVfYVIJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DBT2lEPTB;MD6wO|U5QSEQvF2= MUDTRW5ITVJ?
CAL-39 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3pTWM2OD1yLkC3O|Y3KM7:TR?= NWmzZYg4W0GQR1XS
M14 M1flUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2r4OGlEPTB;MD6wO|kyOyEQvF2= MnTDV2FPT0WU
BFTC-909 M{TEWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLaTWM2OD1yLkC3PVY6KM7:TR?= NWjtNYFqW0GQR1XS
TE-11 NFHDfodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPUN25[UUN3ME2wMlA4QTl4IN88US=> NX31[FB{W0GQR1XS
TGBC1TKB M2LENmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTBwMEiwOFMh|ryP NXPkN4VXW0GQR1XS
L-363 NETyfIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\TW3JKSzVyPUCuNFgzODZizszN NWnWZYNSW0GQR1XS
A431 MmDkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfLOlNQUUN3ME2wMlA5OjFizszN NH\zcohUSU6JRWK=
MKN45 NE\wcYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfqN3BKSzVyPUCuNFgzOTlizszN NUjPVlVHW0GQR1XS
HT-1080 NFHCZXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwMEi0N|kh|ryP M{G4NHNCVkeHUh?=
OVCAR-8 M4O5S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XXTWlEPTB;MD6wPFYzOiEQvF2= MWLTRW5ITVJ?
LCLC-97TM1 NWjV[ZdtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2D6S2lEPTB;MD6wPFczQCEQvF2= MWLTRW5ITVJ?
M059J M2nHWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PzSWlEPTB;MD6wPVAzPyEQvF2= MWDTRW5ITVJ?
SK-MEL-2 NHr4SY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTBwMEmwOkDPxE1? M2LQ[HNCVkeHUh?=
TE-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rOd2lEPTB;MD6wPVIxPCEQvF2= MmTSV2FPT0WU
KYSE-180 MlzoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwMEmyOlIh|ryP MVHTRW5ITVJ?
D-247MG M4L1OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTBwMEm0OVUh|ryP NUXjT216W0GQR1XS
8-MG-BA NUS2ZlFbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;pTnoxUUN3ME2wMlA6PDd{IN88US=> M1y3R3NCVkeHUh?=
NCI-H1792 NUe1boV3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzhV2dKSzVyPUCuNFk3OThizszN MW\TRW5ITVJ?
MCF7 NWHhSFYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY[0UZZOUUN3ME2wMlA6Pjd5IN88US=> NXvCcmwxW0GQR1XS
NCI-H2122 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTn[FZ4UUN3ME2wMlA6PzR3IN88US=> NIXn[mRUSU6JRWK=
EFO-27 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHXTWM2OD1yLkC5PVk4KM7:TR?= NGLXWVNUSU6JRWK=
LB2241-RCC M{j6cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fQR2lEPTB;MD6xNFA2PCEQvF2= NYPMRo9tW0GQR1XS
SN12C NXrvVXl2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTBwMUCxNFch|ryP M{XkUnNCVkeHUh?=
A498 Mlu3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfyTWM2OD1yLkGwNVgh|ryP M3jMdnNCVkeHUh?=
PANC-03-27 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvzWpFkUUN3ME2wMlExOjh4IN88US=> Mnn1V2FPT0WU
NCI-H1581 NULKRWZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwMUCyPUDPxE1? MoOzV2FPT0WU
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G-401 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrRTWM2OD1yLkGwN|U{KM7:TR?= NV3UUGxSW0GQR1XS
SiHa MnriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTBwMUC0PFYh|ryP NYTQR2RuW0GQR1XS
U251 NV24[ohPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;XTWM2OD1yLkGwOVI2KM7:TR?= MoeyV2FPT0WU
MMAC-SF MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLaUHpKSzVyPUCuNVA2OzFizszN MmHIV2FPT0WU
BB65-RCC NFTxcoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfYTWM2OD1yLkGwOVU1KM7:TR?= NHi2WJZUSU6JRWK=
NKM-1 NInsVJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTBwMUC2OlYh|ryP NIfW[3lUSU6JRWK=
HD-MY-Z NYDQdYpWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4raNWlEPTB;MD6xNFg4OyEQvF2= MkLCV2FPT0WU
TGBC11TKB NHuyelhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTBwMUC5NFMh|ryP M1f0cXNCVkeHUh?=
COLO-679 NFP1TFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XLcWlEPTB;MD6xNVIyOSEQvF2= NEXIcphUSU6JRWK=
TE-8 M1zMe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TwU2lEPTB;MD6xNVI3PCEQvF2= M1rOUXNCVkeHUh?=
SK-MEL-28 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;oTWM2OD1yLkGxN|IyKM7:TR?= NGe0c4pUSU6JRWK=
SH-4 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrsNZBKSzVyPUCuNVE{PTZizszN MkLpV2FPT0WU
KALS-1 M1jmOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXT1PYJMUUN3ME2wMlEyOzl|IN88US=> MYXTRW5ITVJ?
RKO NXfES2c3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\HbmlEPTB;MD6xNVc3PCEQvF2= Mn\MV2FPT0WU
OMC-1 MlK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPWTWM2OD1yLkGxO|k4KM7:TR?= NHfneZdUSU6JRWK=
BT-549 M1PJe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoS1TWM2OD1yLkGxO|k6KM7:TR?= NYPSW4RXW0GQR1XS
NCI-H28 M3rL[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTUTWM2OD1yLkGxPFE4KM7:TR?= M1nKU3NCVkeHUh?=
RXF393 M{W0UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljmTWM2OD1yLkGxPVgzKM7:TR?= NHTIZ4pUSU6JRWK=
COLO-829 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTBwMUKwNFUh|ryP MYDTRW5ITVJ?
HMV-II MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jVcGlEPTB;MD6xNlAzKM7:TR?= M1K1VXNCVkeHUh?=
SW1990 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnGwTWM2OD1yLkGyNVU4KM7:TR?= NYq0[3hxW0GQR1XS
NCI-H1437 M4Xmbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELvbGRKSzVyPUCuNVIyPTdizszN NHfqUlVUSU6JRWK=
SNB75 NXnWVZVrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDNTWM2OD1yLkGyNVY6KM7:TR?= NUS0d5lGW0GQR1XS
EW-3 NEjvWJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\2TWM2OD1yLkGyOlYyKM7:TR?= NIm1[4JUSU6JRWK=
SAS M4G4cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnZTWM2OD1yLkGyOlkh|ryP MlLtV2FPT0WU
NCI-H1666 M4XTSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPFUVRKSzVyPUCuNVI4PzRizszN Mn;pV2FPT0WU
A375 MmXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwMUK3O|gh|ryP NFLpTWFUSU6JRWK=
CAMA-1 NVr6V5Y{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfiW|BEUUN3ME2wMlEzQTJ2IN88US=> NEm1SllUSU6JRWK=
HuP-T4 NUjwVHIyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPEb|Z1UUN3ME2wMlEzQTR|IN88US=> MVLTRW5ITVJ?
NCI-H292 M3S5emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTBwMUOxNUDPxE1? NGTzR3dUSU6JRWK=
PC-14 M4\kZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTBwMUOyNVEh|ryP MmnHV2FPT0WU
BPH-1 NVXnbHc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTBwMUO0NUDPxE1? M1zuUnNCVkeHUh?=
GAK MnnTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mom3TWM2OD1yLkGzOVY4KM7:TR?= MmCzV2FPT0WU
VMRC-RCZ MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV6xWZJPUUN3ME2wMlE{PzZ{IN88US=> Mn\uV2FPT0WU
SK-MEL-24 NXXlWZJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3DfWVKSzVyPUCuNVM5PyEQvF2= NET4XmFUSU6JRWK=
LB831-BLC Mnf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7sRYhYUUN3ME2wMlE{QDh|IN88US=> NYXqcI1HW0GQR1XS
NCI-H2452 NVPOUW1wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljWTWM2OD1yLkGzPVU3KM7:TR?= M2LrcXNCVkeHUh?=
RT-112 NGPLUVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17W[WlEPTB;MD6xOFA{PSEQvF2= MnHWV2FPT0WU
GP5d NH\QUlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTBwMUSxNFQh|ryP MYPTRW5ITVJ?
LC-2-ad MmjMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1Oxc2lEPTB;MD6xOFEzOSEQvF2= M1;2UHNCVkeHUh?=
MPP-89 M3jUb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2ftdGlEPTB;MD6xOFEzPSEQvF2= MkPpV2FPT0WU
NUGC-3 NGTYeXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULvOXdRUUN3ME2wMlE1PDd6IN88US=> Mo\EV2FPT0WU
GI-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3OTWM2OD1yLkG0OVU5KM7:TR?= NVewOWM6W0GQR1XS
HCC1419 NF[xeVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\wSGlEPTB;MD6xOFU4PiEQvF2= NIfVTJBUSU6JRWK=
SW1573 M1TDRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTBwMUS3OVgh|ryP MUnTRW5ITVJ?
NCI-H2347 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLqbHJKSzVyPUCuNVQ5OzlizszN NXvuU2pWW0GQR1XS
Mewo MljvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwMUS4PFkh|ryP MYXTRW5ITVJ?
639-V Mo\sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XRTmlEPTB;MD6xOVAyOyEQvF2= NXe5S49xW0GQR1XS
AsPC-1 MlnXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwMUWyNlUh|ryP MoXCV2FPT0WU
NCI-H1648 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;CNXNKUUN3ME2wMlE2OjN{IN88US=> NVj2PGNzW0GQR1XS
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ETK-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2njUGlEPTB;MD6xOVkh|ryP MomyV2FPT0WU
BxPC-3 MnOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrCNllKSzVyPUCuNVU6PjZizszN MVrTRW5ITVJ?
CAL-62 Ml23S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zGRmlEPTB;MD6xOlE3QSEQvF2= NFS0SnRUSU6JRWK=
HCC1937 Ml76S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTBwMU[yO|Uh|ryP Mn3aV2FPT0WU
NCI-H1299 NF\TfWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwMU[yPFUh|ryP NEfy[otUSU6JRWK=
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FTC-133 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;xTWM2OD1yLkG2OVQh|ryP NHS4eWRUSU6JRWK=
OC-314 M1;uXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDlOWVKSzVyPUCuNVY3QSEQvF2= NH7hcFdUSU6JRWK=
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HT-1376 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTBwMU[5N|Yh|ryP MoP2V2FPT0WU
U-2-OS M4XXU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPSUFc3UUN3ME2wMlE4OTd|IN88US=> NXm1dVhZW0GQR1XS
COLO-824 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfmVWhKSzVyPUCuNVczQTRizszN M3KyZ3NCVkeHUh?=
BB30-HNC MlziS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorlTWM2OD1yLkG3N|Mh|ryP NIPYV|RUSU6JRWK=
NCI-H2087 NIPEXW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvsXIFKSzVyPUCuNVc{PjhizszN NYPsbVVUW0GQR1XS
NCI-H2170 NYqzdo5NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTBwMUe1N|Yh|ryP NX\hcFB1W0GQR1XS
SK-OV-3 M4PBXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfye5RKSzVyPUCuNVc2PzFizszN NFjBTI1USU6JRWK=
MZ7-mel NUGwTY9pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnmV3dvUUN3ME2wMlE4PjR7IN88US=> M3H1XXNCVkeHUh?=
NCI-H650 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXf2eWV4UUN3ME2wMlE4Pjh{IN88US=> MXvTRW5ITVJ?
KOSC-2 MoD4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHriUYhKSzVyPUCuNVc4OzRizszN MWfTRW5ITVJ?
SCC-4 MofqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVn0XWd5UUN3ME2wMlE4Pzd5IN88US=> NHL1bWFUSU6JRWK=
MDA-MB-157 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPWVZlKSzVyPUCuNVgxQDJizszN M2TWSnNCVkeHUh?=
KYSE-520 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwMUiyJO69VQ>? NIGzepFUSU6JRWK=
LK-2 NYPRVYloT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nsUmlEPTB;MD6xPFMxOyEQvF2= MkTHV2FPT0WU
KNS-81-FD MkPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPXO41yUUN3ME2wMlE5Ozl2IN88US=> MWfTRW5ITVJ?
IGROV-1 NGDMS2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3L3fWlEPTB;MD6xPFQ1OyEQvF2= MWjTRW5ITVJ?
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NCI-H1395 MnfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWS4c3RtUUN3ME2wMlE5Pjh{IN88US=> MVfTRW5ITVJ?
JEG-3 MlK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnjTWM2OD1yLkG4O|A2KM7:TR?= MVjTRW5ITVJ?
BCPAP NIfscVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTVTWM2OD1yLkG4PFczKM7:TR?= NI\lbmVUSU6JRWK=
CAL-27 MljnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTBwMUmwNlIh|ryP MnOyV2FPT0WU
RD NIL6TXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwMUmxNVMh|ryP MWrTRW5ITVJ?
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COLO-680N MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPZTWM2OD1yLkG5N|Y1KM7:TR?= MWDTRW5ITVJ?
NCI-H1650 NX3IUZdKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7VTWM2OD1yLkKwNFU4KM7:TR?= NE\kN4JUSU6JRWK=
SBC-5 Mo\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTBwMkCxNVgh|ryP NEHaO5FUSU6JRWK=
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DoTc2-4510 NEmwNGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPTTWM2OD1yLkKwO|Y6KM7:TR?= M3POc3NCVkeHUh?=
AM-38 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HWeGlEPTB;MD6yNFg1QCEQvF2= MVvTRW5ITVJ?
A172 NUjR[pE5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjqWmpKSzVyPUCuNlExOjJizszN MXLTRW5ITVJ?
HPAF-II MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrDXlJKSzVyPUCuNlEzPjRizszN MVXTRW5ITVJ?
769-P NVi2[YM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHNS5JKSzVyPUCuNlEzQCEQvF2= MYjTRW5ITVJ?
MFE-280 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moq2TWM2OD1yLkKxNlk5KM7:TR?= MkPlV2FPT0WU
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EoL-1-cell M1\lTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rjWmlEPTB;MD6yNlIxOyEQvF2= M1zme3NCVkeHUh?=
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KYSE-270 NEn6[I9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUS0XlJtUUN3ME2wMlI{ODh2IN88US=> MYrTRW5ITVJ?
TK10 NX3DZZJwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTBwMkOxNVch|ryP NF;6fFRUSU6JRWK=
ML-2 Mlz5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXzSVdHUUN3ME2wMlI{OTF7IN88US=> M1zr[nNCVkeHUh?=
MHH-ES-1 NFzsPW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTBwMkO2PFEh|ryP Mn\qV2FPT0WU
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GR-ST NF3DS4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\SXJlnUUN3ME21MlUzOjBzIN88US=> MV\TRW5ITVJ?
NCI-H1092 NVf0PXRjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHmTWM2OD13LkeyPFQ{KM7:TR?= MnPLV2FPT0WU
647-V MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTVwN{S3NFYh|ryP MVXTRW5ITVJ?
EW-13 M2rQZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoewTWM2OD13Lke2OlI4KM7:TR?= MljlV2FPT0WU
KGN NUXOdpljT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX34UJdEUUN3ME22MlA6QTJzIN88US=> NWnNTWFQW0GQR1XS
D-423MG MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTZwNECyPFQh|ryP M2LxT3NCVkeHUh?=
ECC10 M1rze2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTdwMUCxNFEh|ryP M1XsN3NCVkeHUh?=
TE-5 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DPbWlEPTB;Nz60NVI6QCEQvF2= M4TLcHNCVkeHUh?=
P12-ICHIKAWA NV;ucW9jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jCNWlEPTB;Nz60OVUzOyEQvF2= MVLTRW5ITVJ?
NCI-H82 MortS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjOTWM2OD15LkS1O|AyKM7:TR?= NWi1Z|JTW0GQR1XS
NCI-H1993 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7yUWR1UUN3ME23Mlg{ODZ|IN88US=> NV;od2hVW0GQR1XS
RH-1 NW[3eFlyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjLdZVpUUN3ME23Mlg2OjR2IN88US=> MkW5V2FPT0WU
SW948 NFq2fm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\Q[lhvUUN3ME23Mlk3ODR7IN88US=> NX;tTlNYW0GQR1XS
CAL-33 NYPRN2JUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTdwOUm5N|gh|ryP NFjMNllUSU6JRWK=
U-266 M{\Vd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzETWM2OD16LkG1O|c4KM7:TR?= MUfTRW5ITVJ?
CAL-72 M{\1Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvpTWM2OD16LkKwN|Ih|ryP NXTvT25xW0GQR1XS
SNU-423 Mnn1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LocGlEPTB;OT6zOlY3PiEQvF2= MW\TRW5ITVJ?
KG-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTlwNUi0OVYh|ryP M17wSnNCVkeHUh?=
HCC1395 NULFR4syT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfse4V7UUN3ME25MlkzOzV{IN88US=> NWO0PFNKW0GQR1XS
BE-13 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUj2eHJLUUN3ME2xNE45QDl{IN88US=> M3\lO3NCVkeHUh?=
MKN7 MmLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2[4cmlEPTB;MUCuPVc3PSEQvF2= M2XIZXNCVkeHUh?=
697 MlnZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmr1TWM2OD1zMT6xOFczKM7:TR?= M2LvTHNCVkeHUh?=
LU-135 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGL2dXdKSzVyPUGxMlI{ODdizszN MnrDV2FPT0WU
ES7 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;DO2pKSzVyPUGxMlM{OTNizszN NXfBSW9wW0GQR1XS
SK-HEP-1 NYjBXIVtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfjb5RKSzVyPUGxMlc3PDZizszN NHz6So5USU6JRWK=
BEN NHT0SFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTFzLki1NUDPxE1? NYGycVlSW0GQR1XS
NCI-H1770 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkS2TWM2OD1zMj6xNlYh|ryP M4DOUXNCVkeHUh?=
SW13 NV3iZ5E{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rYfmlEPTB;MUKuNVU1OSEQvF2= NWW4SGZCW0GQR1XS
MZ1-PC M1K1[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzrO4pKSzVyPUGyMlU1PTJizszN MVvTRW5ITVJ?
Mo-T MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HwUWlEPTB;MUKuO|QzOSEQvF2= MW\TRW5ITVJ?
HLE MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXwTWM2OD1zMj64NlE2KM7:TR?= MV;TRW5ITVJ?
RCC10RGB MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTF|Lk[3NUDPxE1? M2C1dnNCVkeHUh?=
COLO-320-HSR NWHzR5V[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PoemlEPTB;MUOuO|M5OSEQvF2= Moj1V2FPT0WU
BHT-101 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonoTWM2OD1zMz64N|Q2KM7:TR?= M2L5ZnNCVkeHUh?=
OCUB-M NID0XoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTF2LkG2NFIh|ryP NFG1VHZUSU6JRWK=
MEG-01 NWX5VotCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLZTWM2OD1zND6zO|A5KM7:TR?= NXfaS|kzW0GQR1XS
RS4-11 M{PBOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\5b45KSzVyPUG0Mlc1OiEQvF2= M4jwSXNCVkeHUh?=
MN-60 NHyyXI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzxb3JKSzVyPUG0Mlc5QTRizszN MVzTRW5ITVJ?
NCI-H1304 M33DbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGe4UZdKSzVyPUG1MlA1OjVizszN MkDsV2FPT0WU
Ramos-2G6-4C10 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zYXmlEPTB;MUWuNFU5OSEQvF2= NWHuVHJmW0GQR1XS
NCI-H2342 NUnmZmVrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1niWmlEPTB;MUWuNlA1PCEQvF2= M{fFbHNCVkeHUh?=
LAN-6 M{HiV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnUTWM2OD1zNT60OFE1KM7:TR?= MVzTRW5ITVJ?
JVM-2 NXH6e5N[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGq1XndKSzVyPUG1MlU4PDhizszN M1HwU3NCVkeHUh?=
P30-OHK MmDRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTF4LkC2NVQh|ryP MWjTRW5ITVJ?
C-33-A NFyw[WZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjRTWM2OD1zNj62NlE1KM7:TR?= Mo\iV2FPT0WU
RPMI-8866 Ml\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{e3SGlEPTB;MU[uPFQ6PiEQvF2= NV3RToVwW0GQR1XS
NCI-H630 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFSwS2JKSzVyPUG2Mlg2OzdizszN MXHTRW5ITVJ?
KYSE-140 NU\QeoRJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInNXotKSzVyPUG3MlIxOjhizszN MnnLV2FPT0WU
T84 MkfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3yO4lKSzVyPUG4Mlg3QTVizszN MnPDV2FPT0WU
KU-19-19 NUHRR2Q2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPmTWM2OD1zOD65OlA5KM7:TR?= NXzUXGs{W0GQR1XS
BALL-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTF7LkOzPVkh|ryP MVvTRW5ITVJ?
Calu-6 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEL5fpNKSzVyPUG5MlQ6OiEQvF2= MYDTRW5ITVJ?
EGI-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTF7LkW5PEDPxE1? M2TBOXNCVkeHUh?=
MFH-ino NXW4O2xuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF:yVpBKSzVyPUG5Mlc1PTRizszN NY\IVnZ4W0GQR1XS
GB-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2q5N2lEPTB;MkCuN|U{PSEQvF2= NFr1SlNUSU6JRWK=
NCI-H1693 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXNSm0yUUN3ME2yNE43PTB3IN88US=> NWDsZ4J4W0GQR1XS
SW1116 M1T1fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjaV5B4UUN3ME2yNE46OzZ{IN88US=> NWTBUGNKW0GQR1XS
H-EMC-SS Mlu0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnuTWM2OD1{Mj6wOFUh|ryP MXLTRW5ITVJ?
D-502MG M1fVXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnTbo5KSzVyPUKyMlgzPjFizszN NVe2TY5NW0GQR1XS
IA-LM M1PEd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MneyTWM2OD1{Mz6yOFk{KM7:TR?= NVrTOm5vW0GQR1XS
SW1463 Mk\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XHXWlEPTB;MkOuO|kh|ryP MYXTRW5ITVJ?
JAR MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVv5UpFpUUN3ME2yOE4{Ojl|IN88US=> M4K3VXNCVkeHUh?=
HT M{\QVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTJ2LkS3OVMh|ryP MX\TRW5ITVJ?
LCLC-103H NX73VXZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\u[nNKSzVyPUK0Mlg1PDlizszN Ml\uV2FPT0WU
SNU-449 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFn4fZhKSzVyPUK0Mlg4PDFizszN NH33doJUSU6JRWK=
KE-37 NX73O3E{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTJ3LkC5Nlgh|ryP M4C5c3NCVkeHUh?=
NCI-H1623 M{jvN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFqx[3pKSzVyPUK3MlE{ODNizszN M1fT[XNCVkeHUh?=
MOLT-13 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDEZlFKSzVyPUK3MlM2OTZizszN MYLTRW5ITVJ?
COLO-741 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLu[nFKSzVyPUOxMlM{OzNizszN NFnHeZBUSU6JRWK=
NB6 MlnSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVH5fopyUUN3ME2zNk4zQDd4IN88US=> M2XKVnNCVkeHUh?=
MOLT-16 M1HlS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFi0cppKSzVyPUOzMlAxPTVizszN M3f6U3NCVkeHUh?=
IST-MES1 M2rVV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zBNmlEPTB;M{SuNFU1OSEQvF2= NEXGWXVUSU6JRWK=
A4-Fuk NVPwV3E4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;IdGlEPTB;M{WuNFY3KM7:TR?= NXLadmltW0GQR1XS
CAL-85-1 M4LFU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmWzTWM2OD1|NT6yPFE4KM7:TR?= MVrTRW5ITVJ?
CCRF-CEM M3fSSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWO1[3ByUUN3ME2zO{4yPTN4IN88US=> NHXLO5JUSU6JRWK=
HAL-01 MmjyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTZV4RKSzVyPUO4MlQ5QDlizszN NVjabI5kW0GQR1XS
HEL NXz0T5N2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XHeWlEPTB;NEOuN|QxQSEQvF2= MkTIV2FPT0WU
EW-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml32TWM2OD12Mz60O|Y5KM7:TR?= MoPYV2FPT0WU
MDA-MB-231 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmn5TWM2OD12NT6xNVk6KM7:TR?= MojpV2FPT0WU
ABC-1 M3;DeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnH1TWM2OD12Nj64OVM5KM7:TR?= NU\Jc|FwW0GQR1XS
NCI-H446 Ml7hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXNZ4VjUUN3ME20PE42ODV6IN88US=> NXj3VYg4W0GQR1XS
MHH-PREB-1 M1HKSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHqToVKSzVyPUS5MlYxODdizszN NXzJNo51W0GQR1XS
DOHH-2 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTR7Lk[2OVYh|ryP MYHTRW5ITVJ?
GCT M3\1SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjNTWM2OD12OT62PVc3KM7:TR?= MWfTRW5ITVJ?

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
α-Synuclein / HSP90 / HSP70 / HSP32 / αB-Crystallin; 

PubMed: 20090920     


Immunoblot analysis of heat shock protein induction. Cells were treated with 17-AAG (1–200 nM, 24 h), or subjected to heat shock (HS: 44°C, 30 min, 24 h recovery) or to MG-132 (MG: 1 µM, 24 h). Cell lysates were prepared and immunoblot analysis was carried out with antibodies against the individual proteins as indicated on the right. Co, untreated control.

EGFR / PDGFR / AKT / MAPK / c-RAS; 

PubMed: 18682579     


17-AAG promotes the degradation of HSP90 client proteins that are involved in the pathology of glioblastoma multiforme (GBM). Glioma cell lines were treated with increasing concentrations of 17-AAG for 48 h, and protein lysates were run on Western blots. HSP90 client proteins known to be involved in gliomagenesis showed degradation while nonclient proteins remained unaffected by 17-AAG treatment.

pAKT / pMAPK / pRb; 

PubMed: 18682579     


The phosphorylated states of signaling proteins involved in glioma growth are also affected by 17-AAG treatment.

Cleaved PARP / Survivin; 

PubMed: 18827603     


Western analysis of expression levels of cleaved PARP and Survivin in MM cell lines. β-Actin served as loading control.

LATS1 / p-LATS1 / YAP / CTGF; 

PubMed: 25712415     


Effects of 17-AAG on the expression of LATS1, p-LATS1, YAP and CTGF.  The expression levels of YAP and CTGF proteins, indicated by Western blot assay, were down-regulated, while LATS1 was upregulated in a dose-dependent manner in 17-AAG treated groups compared to the untreated group.

20090920 18682579 18827603 25712415
Immunofluorescence
STAT3; 

PubMed: 27279418     


Effects of 17-AAG on STAT3 expression of H446 cells. (A) Control group; (B) 3.125 mg/l; (C) 6.25 mg/l. 17-AAG, 17-allylamino-17-demethoxygel-danamycin; STAT3, signal transducer and activator of transcription 3; DAPI, 4′,6-diamidino-2-phenylindole.

YAP / TAZ; 

PubMed: 25290150     


Reduction in cytoplasmic distribution accompanied by increased nuclear localization of YAP/TAZ was more apparent in cells treated with 45 nM 17-AAG (red channel for YAP/TAZ and blue channel for nucleus). Statistical comparisons were performed using one-way Kruskal-Wallis multiple comparison, ***p<0.001 compared with control (0 nM).

β-catenin / E-cadherin; 

PubMed: 25290150     


Co-localization of β-catenin (Red) and E-cadherin (Green) was observed at the cell-cell junctions (white arrows) both in siCtrl and siCTGF cells after 17-AAG treatment. Scale bar is 20 µm.

27279418 25290150
Growth inhibition assay
Cell viability; 

PubMed: 18682579     


17-AAG inhibits the growth of human glioma cell lines. Human glioma cell lines and a nontumorigenic fibroblast cell line were treated with increasing concentrations of 17-AAG for 4 days, and the effect on cell growth was assessed by a 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt (MTS) assay. The 50% inhibitory concentration (IC50) of all glioma cell lines ranged from 0.05 to 0.5 μM 17-AAG, as compared to 1.5 μM for the nontumorigenic cells.

18682579
体内研究 17-AAG作用于携带3T3-src, B16或CT26移植瘤裸鼠,与Hsp90结合具有高亲和力,IC50为8-35 nM,而作用于正常组织时,IC50为200-600 nM。[1] 17-AAG按50 mg/kg左右剂量处理,引起AR, HER2, HER3, 和 Akt表达明显降低,降低达50%以上,这种作用存在剂量依赖性,结果导致雄激素依赖型 (CWR22)和非依赖型(CWR22R 和CWRSA6) 前列腺移植瘤生长受抑制,抑制率分别为67%, 80%和 68%。[2]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[1]
- 合并

Hsp90结合实验:

纯化的Hsp90蛋白或过量表达HER-2的癌细胞(BT474, N87, SKOV3 和 SKBR3) 裂解物或BT474乳腺癌细胞溶于溶解buffer(20 mM HEPES, pH 7.3, 1 mM EDTA, 5 mM MgCl2, 100 mM KCl) ,与不同浓度17-AAG在4oC下温育30分钟,然后和生物素-GM链接的BioMag链霉亲和素磁珠在4oC下温育1小时。试管放置于磁架上,除去未结合的上清液。在溶解buffer中清洗三次磁珠,然后在SDS–PAGE 样本缓冲液中在95oC下加热5分钟。在SDS蛋白凝胶上进行样本分析,使用特点抗体进行Western Blotting。使用Bio-rad Fluor-S 多重图像测量Western Blot条带,计算抑制Hsp90与生物素-GM结合的百分数。测定IC50。
细胞实验:[1]
- 合并
  • Cell lines: BT474, SKBR3, N87, SKOV3, MCF7, MDA468, Hs578T, Hs578Bst, A549, HT29, U87, SKMG3, HT1080, RPTEC, NDF, HMVEC, HMEC, HUVEC, 和 PBMC
  • Concentrations: 溶于DMSO, 终浓度为10 μM 左右
  • Incubation Time: 5天
  • Method: 细胞按每孔2000个接种在96孔板上,终培养体积为100 μL,培养24小时, 然后加入浓度不断增高的17-AAG,温育5天。使用 Celltiter 96 AQueous 非放射性细胞增殖检测试剂盒测定存活细胞数。测定IC50。
    (Only for Reference)
动物实验:[2]
- 合并
  • Animal Models: 皮下注射雄激素依赖性CWR22移植瘤的雄性 nu/nu 无胸腺小鼠, 皮下注射雄激素非依赖性的CWR22R和CWRSA6移植瘤的雌性nu/nu 无胸腺小鼠。
  • Dosages: 50 mg/kg 左右
  • Administration: 腹膜注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 100 mg/mL (170.73 mM)
Water Insoluble
Ethanol '5 mg/mL
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5%DMSO+corn oil
10mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 585.69
化学式

C31H43N3O8

CAS号 75747-14-7
储存条件 粉状
溶于溶剂
别名 CP127374,NSC-330507, KOS 953

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00103272 Terminated Drug: tanespimycin|Drug: bortezomib Adult Acute Basophilic Leukemia|Adult Acute Eosinophilic Leukemia|Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Nodal Marginal Zone B-cell Lymphoma|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult T-cell Leukemia/Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Refractory Chronic Lymphocytic Leukemia|Small Intestine Lymphoma|Splenic Marginal Zone Lymphoma|Waldenström Macroglobulinemia National Cancer Institute (NCI) April 2005 Phase 1
NCT00098488 Terminated Drug: tanespimycin|Biological: rituximab B-cell Chronic Lymphocytic Leukemia|Prolymphocytic Leukemia|Refractory Chronic Lymphocytic Leukemia National Cancer Institute (NCI) April 2005 Phase 1
NCT00118248 Completed Drug: tanespimycin Recurrent Thyroid Cancer|Stage IV Follicular Thyroid Cancer|Stage IV Papillary Thyroid Cancer|Thyroid Gland Medullary Carcinoma National Cancer Institute (NCI) December 2004 Phase 2
NCT00098423 Completed Drug: tanespimycin|Drug: cytarabine Accelerated Phase Chronic Myelogenous Leukemia|Adult Acute Basophilic Leukemia|Adult Acute Eosinophilic Leukemia|Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Blastic Phase Chronic Myelogenous Leukemia|Chronic Myelomonocytic Leukemia|de Novo Myelodysplastic Syndromes|Previously Treated Myelodysplastic Syndromes|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia|Refractory Anemia With Excess Blasts in Transformation|Relapsing Chronic Myelogenous Leukemia|Secondary Acute Myeloid Leukemia|Secondary Myelodysplastic Syndromes National Cancer Institute (NCI) November 2004 Phase 1

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操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    What kind of subtypes does this compound inhibit? HSP90α or HSP90β ?

  • 回答:

    17-AAG can inhibit both HSP90α and HSP90β, but it is unclear how much are they affected respectively. You should note that Hsp90 derived from tumor cells has a 100-fold higher binding affinity for 17-AAG than that from normal cells according to this paper. http://www.nature.com.ezp-prod1.hul.harvard.edu/nature/journal/v425/n6956/full/nature01913.html

HSP (HSP90) Signaling Pathway Map

HSP (HSP90) Inhibitors with Unique Features

相关HSP (HSP90)产品

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID