Tanespimycin (17-AAG)

目录号:S1141 别名: CP127374,NSC-330507, KOS 953

Tanespimycin (17-AAG) Chemical Structure

Molecular Weight(MW): 585.69

Tanespimycin (17-AAG)是一种有效的HSP90抑制剂,无细胞试验中IC50为5 nM,作用于来自肿瘤细胞的HSP90比作用于来自正常细胞HSP90结合亲和力高100倍。Phase 2。

规格 价格 库存 购买数量  
In DMSO RMB 1597.01 现货
RMB 1221.85 现货
RMB 3016.43 现货
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客户使用Selleck该产品发表文献35篇:

产品安全说明书

HSP (e.g. HSP90)抑制剂选择性比较

生物活性

产品描述 Tanespimycin (17-AAG)是一种有效的HSP90抑制剂,无细胞试验中IC50为5 nM,作用于来自肿瘤细胞的HSP90比作用于来自正常细胞HSP90结合亲和力高100倍。Phase 2。
特性 17-AAG对正常细胞的毒性很小。
靶点
HSP90 [1]
(Cell-free assay)
5 nM
体外研究

17-AAG是格尔德霉素类似物, 但是与过量表达HER-2的癌细胞 (BT474, N87, SKOV3 和SKBR3)或BT474乳腺细胞衍生的Hsp90亲和力高100多倍,IC50为5-6 nM, 而作用于正常人类原代细胞时,IC50为400-943 nM, 因为肿瘤Hsp90 处于多伴复合体状态,具有高ATP酶活性,而正常细胞Hsp90 处于潜在未结合状态, 且直接与那些细胞中17-AAG毒性相关。[1]17-AAG 引起HER2, HER3, Akt,突变和野生型雄激素受体(AR)降解,导致前列腺细胞如LNCaP, LAPC-4, DU-145,和PC-3中RB依赖的 G1 期生长停顿,IC50为25-45 nM。[2]除了诱导改变野生型BCR-ABL的Ba/F3细胞凋亡, IC50为5.2 μM, 17-AAG还通过诱导野生型和突变型 BCR-ABL蛋白降解,而诱导改变抗 Imatinib Mesylate的 T315I和 E255K BCR-ABL突变型细胞生长,IC50分别为2.3 μM 和 1.0 μM。[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A549 Mlr4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jLZ2lEPTB;MD6wNFA{ODNizszN NWnLO3FqW0GQR1XS
IST-MEL1 M322Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV22PVFqUUN3ME2wMlAxODRyNzFOwG0> M1TqfHNCVkeHUh?=
NCI-SNU-1 NIntO4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHn0dZRKSzVyPUCuNFAzODdizszN M370[XNCVkeHUh?=
FADU NYTlbHdJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LPSGlEPTB;MD6wNFIxQSEQvF2= NGTVVHpUSU6JRWK=
C32 M3zlNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwMECzNFQh|ryP M36yNnNCVkeHUh?=
D-566MG NHLDU2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{flXWlEPTB;MD6wNFM6KM7:TR?= NXzheHlCW0GQR1XS
LXF-289 M4XrNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjSTWM2OD1yLkCwOFE6KM7:TR?= MX\TRW5ITVJ?
HGC-27 NH;peIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LOdWlEPTB;MD6wNFUyKM7:TR?= MnP2V2FPT0WU
RPMI-7951 Mn61S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETMfJpKSzVyPUCuNFA4OTdizszN MV7TRW5ITVJ?
HSC-3 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDYTWM2OD1yLkCwPVI6KM7:TR?= NFTmPFlUSU6JRWK=
MIA-PaCa-2 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLnXJExUUN3ME2wMlAyODB7IN88US=> Ml\WV2FPT0WU
KS-1 NIjq[5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nWNGlEPTB;MD6wNVM2PSEQvF2= NVewPIJFW0GQR1XS
CAL-51 NIXxVYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVO3cYVTUUN3ME2wMlAyPDB3IN88US=> MVXTRW5ITVJ?
MDA-MB-361 NEPrRY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTBwMEG0PVUh|ryP MWPTRW5ITVJ?
TI-73 MnHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIi4SVJKSzVyPUCuNFE4QTZizszN MYDTRW5ITVJ?
AGS MoGxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fQXmlEPTB;MD6wNVk{QCEQvF2= NYTmUWR4W0GQR1XS
NCI-H460 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PV[mlEPTB;MD6wNVk4PCEQvF2= MmXrV2FPT0WU
A204 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPycJZKSzVyPUCuNFIzPDlizszN MnjCV2FPT0WU
CHL-1 M2TGemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHGz[pBKSzVyPUCuNFIzPTFizszN MmP0V2FPT0WU
DU-4475 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTBwMEKyOlEh|ryP M{S1U3NCVkeHUh?=
CGTH-W-1 M{KwPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwMEKzOFkh|ryP M1vPOHNCVkeHUh?=
HCC2218 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVq5bmZyUUN3ME2wMlAzPDl2IN88US=> M1j6PHNCVkeHUh?=
A2780 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHr5blFKSzVyPUCuNFI2OzFizszN NGfPOplUSU6JRWK=
NCI-H720 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLyTWM2OD1yLkCyOVQ3KM7:TR?= MWPTRW5ITVJ?
NCI-N87 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LHOGlEPTB;MD6wNlU6OyEQvF2= MYDTRW5ITVJ?
CHP-212 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrPUYxuUUN3ME2wMlAzPjJ6IN88US=> M2fKXHNCVkeHUh?=
NCI-H23 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHzTWM2OD1yLkCyOlY2KM7:TR?= NH;XfYRUSU6JRWK=
D-263MG MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGn0PFJKSzVyPUCuNFI4QDZizszN M2WxdHNCVkeHUh?=
ME-180 M1vEN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jGRmlEPTB;MD6wNlg6OSEQvF2= NH3Db5VUSU6JRWK=
SW982 MlzvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjITWM2OD1yLkCyPVk6KM7:TR?= M4HpcnNCVkeHUh?=
OE19 NGH0WFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnuzTWM2OD1yLkCzNFc4KM7:TR?= NYXkd2NIW0GQR1XS
SK-LU-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPVfIRKSzVyPUCuNFMxQDJizszN Mm[3V2FPT0WU
H4 NXjJcnJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\NUXJKSzVyPUCuNFMxQSEQvF2= NFnidG5USU6JRWK=
HT-144 NWjxdVZ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwMEOwPVMh|ryP MWjTRW5ITVJ?
SK-UT-1 NFrLOo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXwTG1kUUN3ME2wMlA{OTd6IN88US=> Mn\UV2FPT0WU
D-336MG NIrjb5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH24e2lKSzVyPUCuNFM{ODlizszN MYLTRW5ITVJ?
MDA-MB-175-VII MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3L4XGlEPTB;MD6wN|M2PCEQvF2= NGPNWXNUSU6JRWK=
GAMG MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PEVGlEPTB;MD6wN|Q{PSEQvF2= Ml22V2FPT0WU
CP50-MEL-B MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTBwMEO0OUDPxE1? MUDTRW5ITVJ?
OVCAR-5 NGjTdWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwMEO0PEDPxE1? NFjEOXdUSU6JRWK=
SK-MES-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljVTWM2OD1yLkCzOlA3KM7:TR?= NEXDUGNUSU6JRWK=
VM-CUB-1 NWD2S4MxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XyO2lEPTB;MD6wN|Y2PyEQvF2= NWj1WFdRW0GQR1XS
WM-115 M33MZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2O4[WlEPTB;MD6wN|c3OiEQvF2= M3[2fHNCVkeHUh?=
DSH1 NUDGdoJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml6zTWM2OD1yLkCzPFA4KM7:TR?= NIC5d2dUSU6JRWK=
Becker MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13BWWlEPTB;MD6wN|g5PSEQvF2= MVXTRW5ITVJ?
SW962 NVrFRWhvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTBwMEO5OFUh|ryP NYDMdGpwW0GQR1XS
TYK-nu NFv5R3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHhUFhnUUN3ME2wMlA{QTh3IN88US=> NF;QWHNUSU6JRWK=
HO-1-N-1 Mk\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXNN4tKSzVyPUCuNFQxOjFizszN M3fidHNCVkeHUh?=
T98G M{jXVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\FSZBwUUN3ME2wMlA1OTB|IN88US=> M4XreXNCVkeHUh?=
ACN NUfSdmZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7nZnFoUUN3ME2wMlA1OTZ{IN88US=> MoO5V2FPT0WU
SW780 Mlu2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7wSVFFUUN3ME2wMlA1OjB|IN88US=> M1HmdHNCVkeHUh?=
Detroit562 M4HhNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TBXmlEPTB;MD6wOFI{QSEQvF2= MofyV2FPT0WU
BB49-HNC Ml3lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2P0N2lEPTB;MD6wOFI1OyEQvF2= NV34cVliW0GQR1XS
HN NWDxVZRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzBZ5RKUUN3ME2wMlA1Ojd{IN88US=> M3;LcXNCVkeHUh?=
H9 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXlWGZKSzVyPUCuNFQ{PzFizszN NYK4dXpYW0GQR1XS
VA-ES-BJ NE\lTXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkOwTWM2OD1yLkC0OFQ4KM7:TR?= M2Ppb3NCVkeHUh?=
MEL-JUSO MorWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLDTWM2OD1yLkC0OFc2KM7:TR?= MWDTRW5ITVJ?
BT-474 NH;6TlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnftTWM2OD1yLkC0OUDPxE1? MYPTRW5ITVJ?
CaR-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjFcpRKSzVyPUCuNFQ2PDlizszN M{O1cXNCVkeHUh?=
PSN1 NIXub4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LK[2lEPTB;MD6wOFYxOyEQvF2= MWPTRW5ITVJ?
KYSE-510 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjFTWM2OD1yLkC0OlQ6KM7:TR?= M4PMOXNCVkeHUh?=
KP-4 NUfPfINRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzv[m1KSzVyPUCuNFQ4PTNizszN M1T6e3NCVkeHUh?=
KYSE-410 NXHadGp5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDFZnVIUUN3ME2wMlA1Pzd{IN88US=> M4nrbXNCVkeHUh?=
G-402 NIO2T2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLGOJBYUUN3ME2wMlA1Pzh7IN88US=> MnXvV2FPT0WU
DOK NX7Qe2xZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTBwMES5NFIh|ryP MmXRV2FPT0WU
COR-L88 NYrlOWZ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnsTWM2OD1yLkC0PVEzKM7:TR?= NGP1fmFUSU6JRWK=
SKG-IIIa MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XFXWlEPTB;MD6wOFk5PiEQvF2= NILzcIFUSU6JRWK=
AN3-CA NVHjTmJjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfGVJBKSzVyPUCuNFUh|ryP MojVV2FPT0WU
SW48 MoXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTBwMEWwN|kh|ryP MXLTRW5ITVJ?
YKG-1 M1jqbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LrfmlEPTB;MD6wOVA4OSEQvF2= M1vsdnNCVkeHUh?=
KYSE-150 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXGxdVRWUUN3ME2wMlA2OjN3IN88US=> NHjGdVRUSU6JRWK=
HuO-3N1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTBwMEWyN|ch|ryP MVrTRW5ITVJ?
LB1047-RCC NGfkPWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWX6b3ZZUUN3ME2wMlA2Ojl4IN88US=> M{PaO3NCVkeHUh?=
NCI-H2030 NEn2bpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfDTWM2OD1yLkC1OFE1KM7:TR?= M1zX[3NCVkeHUh?=
YH-13 Ml6yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\ITWM2OD1yLkC1O|IzKM7:TR?= NF\6fGlUSU6JRWK=
5637 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTBwMEW3OEDPxE1? M4WwNHNCVkeHUh?=
LOXIMVI NIHOU4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHLSI5iUUN3ME2wMlA2QDd{IN88US=> Mm\QV2FPT0WU
GT3TKB NInHUWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwMEW5OFIh|ryP MXzTRW5ITVJ?
TCCSUP NGG4SHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nOfGlEPTB;MD6wOVk3PCEQvF2= MUnTRW5ITVJ?
EPLC-272H NWjWTYdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnvPZpTUUN3ME2wMlA3OjB3IN88US=> MmH3V2FPT0WU
LU-99A NVH2bHpQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moi4TWM2OD1yLkC2NlM4KM7:TR?= NGG0UnlUSU6JRWK=
NCI-H1755 NHmwNZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;VWmlEPTB;MD6wOlM1OSEQvF2= M2jpNnNCVkeHUh?=
KM12 M{TzeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHyTGl7UUN3ME2wMlA3OzR6IN88US=> M3LRbHNCVkeHUh?=
SF295 NY\3SXpKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Hx[WlEPTB;MD6wOlQ2OiEQvF2= M4mxT3NCVkeHUh?=
MZ2-MEL NEO0NoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vlOWlEPTB;MD6wOlU2OyEQvF2= NIrsS5dUSU6JRWK=
HEC-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfWZ4xKSzVyPUCuNFY2QDhizszN M4K2[nNCVkeHUh?=
SW684 NXPTPVZ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XlTGlEPTB;MD6wOlU6OSEQvF2= NG[wcoFUSU6JRWK=
SF539 MlvsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUGyTXo{UUN3ME2wMlA3PjhzIN88US=> NYnkVVAyW0GQR1XS
GMS-10 NH;R[HRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHCeY9RUUN3ME2wMlA3Pjl7IN88US=> MXPTRW5ITVJ?
MV-4-11 NWTHO3BnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fVNmlEPTB;MD6wOlgxOyEQvF2= NGf6eVRUSU6JRWK=
HT-29 MoDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwME[5NVkh|ryP NVS1ZZNZW0GQR1XS
23132-87 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPZTWM2OD1yLkC2PVUh|ryP MVTTRW5ITVJ?
SW620 NUDKd2RkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\KTWM2OD1yLkC3NFI3KM7:TR?= NVTyfVZMW0GQR1XS
HCC1806 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTBwMEexN|Eh|ryP NIPydnZUSU6JRWK=
Hs-578-T MlvoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLaNY5UUUN3ME2wMlA4OjB6IN88US=> NGrzU5RUSU6JRWK=
A2058 MmqyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPtTWM2OD1yLkC3NlI5KM7:TR?= MU\TRW5ITVJ?
MEL-HO M{fVbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonwTWM2OD1yLkC3NlU2KM7:TR?= MnewV2FPT0WU
HCC2998 M{XvTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTBwMEezOFch|ryP MWfTRW5ITVJ?
HuO9 NGDTVnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\LTWM2OD1yLkC3OVg6KM7:TR?= NInnNG9USU6JRWK=
CAL-39 M3TGXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLEfWRKSzVyPUCuNFc4PjZizszN MlrDV2FPT0WU
M14 NHSy[JBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUG3XJZ3UUN3ME2wMlA4QTF|IN88US=> MVzTRW5ITVJ?
BFTC-909 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\2TWM2OD1yLkC3PVY6KM7:TR?= M{jUPHNCVkeHUh?=
TE-11 MlXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDQOWdKSzVyPUCuNFc6QTZizszN NGHqOXNUSU6JRWK=
TGBC1TKB M{\SdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rmSmlEPTB;MD6wPFA1OyEQvF2= Ml[3V2FPT0WU
L-363 M2roNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTBwMEiyNFYh|ryP MWDTRW5ITVJ?
A431 NUn6bnl7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDGNYpKSzVyPUCuNFgzOSEQvF2= NFPsO2FUSU6JRWK=
MKN45 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHP5XlJKSzVyPUCuNFgzOTlizszN Mn;mV2FPT0WU
HT-1080 NF\ZZ2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjHTWM2OD1yLkC4OFM6KM7:TR?= NXe3O4puW0GQR1XS
OVCAR-8 MnLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTBwMEi2NlIh|ryP NVvJSVY3W0GQR1XS
LCLC-97TM1 M33NNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXlTWM2OD1yLkC4O|I5KM7:TR?= NV;FeHBMW0GQR1XS
M059J M2C5bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnryTWM2OD1yLkC5NFI4KM7:TR?= M2PUOXNCVkeHUh?=
SK-MEL-2 NXLneI5KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrLTWM2OD1yLkC5NFYh|ryP NUjZNlBHW0GQR1XS
TE-1 NILX[4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3vTWM2OD1yLkC5NlA1KM7:TR?= NXjDT|hyW0GQR1XS
KYSE-180 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTicJV1UUN3ME2wMlA6OjZ{IN88US=> MVLTRW5ITVJ?
D-247MG MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37QW2lEPTB;MD6wPVQ2PSEQvF2= NFzZd4VUSU6JRWK=
8-MG-BA MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{[2[WlEPTB;MD6wPVQ4OiEQvF2= MVnTRW5ITVJ?
NCI-H1792 MlT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrIb4FIUUN3ME2wMlA6PjF6IN88US=> MXfTRW5ITVJ?
MCF7 NITOXo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rZ[2lEPTB;MD6wPVY4PyEQvF2= MVXTRW5ITVJ?
NCI-H2122 NYHBWI5YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwMEm3OFUh|ryP NVvvVIJSW0GQR1XS
EFO-27 Mn;RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;lW2lEPTB;MD6wPVk6PyEQvF2= M4nvRXNCVkeHUh?=
LB2241-RCC NFjnOXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPE[VhKSzVyPUCuNVAxPTRizszN M{PSSHNCVkeHUh?=
SN12C M3\v[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzOOlJnUUN3ME2wMlExOTB5IN88US=> MULTRW5ITVJ?
A498 Ml7lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTBwMUCxPEDPxE1? NFi3eolUSU6JRWK=
PANC-03-27 M{nuO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnsboxKSzVyPUCuNVAzQDZizszN NXHQVJNRW0GQR1XS
NCI-H1581 M2HHXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTBwMUCyPUDPxE1? MoO2V2FPT0WU
U-87-MG M4r5cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTBwMUCzNFch|ryP M3jrXnNCVkeHUh?=
G-401 NULjc2EyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTBwMUCzOVMh|ryP NHvvVmJUSU6JRWK=
SiHa MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jUS2lEPTB;MD6xNFQ5PiEQvF2= MUPTRW5ITVJ?
U251 NUfq[4ZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2GydWlEPTB;MD6xNFUzPSEQvF2= NWPmOnY1W0GQR1XS
MMAC-SF NX\tcI1oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrLTWM2OD1yLkGwOVMyKM7:TR?= MoPXV2FPT0WU
BB65-RCC MknuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nwbGlEPTB;MD6xNFU2PCEQvF2= NEnLd4lUSU6JRWK=
NKM-1 MlrGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvkTWM2OD1yLkGwOlY3KM7:TR?= M1K1NnNCVkeHUh?=
HD-MY-Z MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEK3eZJKSzVyPUCuNVA5PzNizszN NIjLbVVUSU6JRWK=
TGBC11TKB MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfE[IJKSzVyPUCuNVA6ODNizszN NXO4S4dFW0GQR1XS
COLO-679 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUe0[IU{UUN3ME2wMlEyOjFzIN88US=> NGXyeFZUSU6JRWK=
TE-8 M3fCR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLnTWM2OD1yLkGxNlY1KM7:TR?= MWLTRW5ITVJ?
SK-MEL-28 NVjRbHNTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfpUVJ7UUN3ME2wMlEyOzJzIN88US=> NULMZWRiW0GQR1XS
SH-4 NUDuVnd[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfQTWM2OD1yLkGxN|U3KM7:TR?= M4W0c3NCVkeHUh?=
KALS-1 M3\Lcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDSTWM2OD1yLkGxN|k{KM7:TR?= NYjjWItMW0GQR1XS
RKO M1zvc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGj5XJNKSzVyPUCuNVE4PjRizszN MonOV2FPT0WU
OMC-1 MmrxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTBwMUG3PVch|ryP MljNV2FPT0WU
BT-549 MorOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XqNGlEPTB;MD6xNVc6QSEQvF2= NH3VPJhUSU6JRWK=
NCI-H28 NV3kRXRrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfYRWtCUUN3ME2wMlEyQDF5IN88US=> NHPHS3NUSU6JRWK=
RXF393 NEjte5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXk[XpIUUN3ME2wMlEyQTh{IN88US=> NHrCfIVUSU6JRWK=
COLO-829 NInXR2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3WUZBKSzVyPUCuNVIxODVizszN M37oPHNCVkeHUh?=
HMV-II NHvYPYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrmWHFVUUN3ME2wMlEzODJizszN NGDyNmJUSU6JRWK=
SW1990 NUKwS5NST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTBwMUKxOVch|ryP Mo\pV2FPT0WU
NCI-H1437 NVr1[YJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjYOZcyUUN3ME2wMlEzOTV5IN88US=> MWDTRW5ITVJ?
SNB75 M{P2N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPYWFRlUUN3ME2wMlEzOTZ7IN88US=> Mk\kV2FPT0WU
EW-3 MnfmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HkVWlEPTB;MD6xNlY3OSEQvF2= NWfZbZhSW0GQR1XS
SAS NYSzdVVtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETQbVhKSzVyPUCuNVI3QSEQvF2= NHX6XItUSU6JRWK=
NCI-H1666 MmOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\Ub2lEPTB;MD6xNlc4PCEQvF2= NGDUO4pUSU6JRWK=
A375 MoXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTBwMUK3O|gh|ryP M3LUbXNCVkeHUh?=
CAMA-1 NHXiR2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTBwMUK5NlQh|ryP NGPYSZNUSU6JRWK=
HuP-T4 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDjVWRsUUN3ME2wMlEzQTR|IN88US=> M3PBW3NCVkeHUh?=
NCI-H292 M{D4Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfHbVRKSzVyPUCuNVMyOSEQvF2= MUHTRW5ITVJ?
PC-14 NUXUfVdsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLPTWM2OD1yLkGzNlEyKM7:TR?= NIDmWYdUSU6JRWK=
BPH-1 NX3pNmJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPrPYlHUUN3ME2wMlE{PDFizszN MmPUV2FPT0WU
GAK NFTZTGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVmz[IQzUUN3ME2wMlE{PTZ5IN88US=> NXXlOHNRW0GQR1XS
VMRC-RCZ M2D1V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fy[WlEPTB;MD6xN|c3OiEQvF2= MlLoV2FPT0WU
SK-MEL-24 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVL6Xld5UUN3ME2wMlE{QDdizszN MYTTRW5ITVJ?
LB831-BLC MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTBwMUO4PFMh|ryP MWrTRW5ITVJ?
NCI-H2452 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwMUO5OVYh|ryP Mlz5V2FPT0WU
RT-112 M2j0Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLHTWM2OD1yLkG0NFM2KM7:TR?= MkDSV2FPT0WU
GP5d MlXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnP0TWM2OD1yLkG0NVA1KM7:TR?= M3vUUHNCVkeHUh?=
LC-2-ad M4TUb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkO0TWM2OD1yLkG0NVIyKM7:TR?= Mn7wV2FPT0WU
MPP-89 NXLZ[HRbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3hTWM2OD1yLkG0NVI2KM7:TR?= Ml;oV2FPT0WU
NUGC-3 M2OzN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn[yTWM2OD1yLkG0OFc5KM7:TR?= M{jqUnNCVkeHUh?=
GI-1 NHPkVVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrrSmxVUUN3ME2wMlE1PTV6IN88US=> MlnNV2FPT0WU
HCC1419 Ml7QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTBwMUS1O|Yh|ryP Mn;6V2FPT0WU
SW1573 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XnV2lEPTB;MD6xOFc2QCEQvF2= MmjTV2FPT0WU
NCI-H2347 NWfh[HZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELXW5hKSzVyPUCuNVQ5OzlizszN MUTTRW5ITVJ?
Mewo MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmGzTWM2OD1yLkG0PFg6KM7:TR?= MkTFV2FPT0WU
639-V NV7QPZR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrCW3JKSzVyPUCuNVUxOTNizszN NFTQSoNUSU6JRWK=
AsPC-1 NXjsZldFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnf3TWM2OD1yLkG1NlI2KM7:TR?= MWXTRW5ITVJ?
NCI-H1648 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rKXGlEPTB;MD6xOVI{OiEQvF2= MYPTRW5ITVJ?
786-0 Mo\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTBwMUWzPFEh|ryP M2n1NHNCVkeHUh?=
ETK-1 M4nOPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTBwMUW5JO69VQ>? NH3xb4tUSU6JRWK=
BxPC-3 NV:yVZRsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fQ[2lEPTB;MD6xOVk3PiEQvF2= M4LZTnNCVkeHUh?=
CAL-62 MnPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjzU|VZUUN3ME2wMlE3OTZ7IN88US=> NXfzSlBVW0GQR1XS
HCC1937 NIHYUlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPtTWM2OD1yLkG2Nlc2KM7:TR?= M2nqRXNCVkeHUh?=
NCI-H1299 MmjWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nXRWlEPTB;MD6xOlI5PSEQvF2= NEXrepNUSU6JRWK=
SW1088 MlTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7sTWM2OD1yLkG2OFE{KM7:TR?= NGDZ[4lUSU6JRWK=
FTC-133 NUfK[5lFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTBwMU[1OEDPxE1? NEHX[GJUSU6JRWK=
OC-314 NF7JdHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PvZWlEPTB;MD6xOlY6KM7:TR?= NF[0Z4tUSU6JRWK=
SCC-9 NYXmO2czT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlX0TWM2OD1yLkG2O|E3KM7:TR?= MVvTRW5ITVJ?
HT-1376 NUe4fJBQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\nOpNPUUN3ME2wMlE3QTN4IN88US=> MWLTRW5ITVJ?
U-2-OS MlzmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfBcoNxUUN3ME2wMlE4OTd|IN88US=> MU\TRW5ITVJ?
COLO-824 NFP0flVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTETWM2OD1yLkG3Nlk1KM7:TR?= MWfTRW5ITVJ?
BB30-HNC M37aTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;pTWM2OD1yLkG3N|Mh|ryP NILJcJdUSU6JRWK=
NCI-H2087 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofwTWM2OD1yLkG3N|Y5KM7:TR?= MXzTRW5ITVJ?
NCI-H2170 NYXrUGs{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPxTWM2OD1yLkG3OVM3KM7:TR?= NHrzW4JUSU6JRWK=
SK-OV-3 Mo\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{D5OmlEPTB;MD6xO|U4OSEQvF2= MkK1V2FPT0WU
MZ7-mel MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\Jb|VKSzVyPUCuNVc3PDlizszN MXrTRW5ITVJ?
NCI-H650 MlyxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYW5RXRCUUN3ME2wMlE4Pjh{IN88US=> M3HufXNCVkeHUh?=
KOSC-2 MkfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWj2fFRuUUN3ME2wMlE4PzN2IN88US=> NVvpUm1UW0GQR1XS
SCC-4 MnHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fVSWlEPTB;MD6xO|c4PyEQvF2= NYL1R3B1W0GQR1XS
MDA-MB-157 MnfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTBwMUiwPFIh|ryP M4XXPHNCVkeHUh?=
KYSE-520 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkT3TWM2OD1yLkG4NkDPxE1? MnTXV2FPT0WU
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KNS-81-FD MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfKfZZkUUN3ME2wMlE5Ozl2IN88US=> NHPyPVVUSU6JRWK=
IGROV-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{npWWlEPTB;MD6xPFQ1OyEQvF2= M4LmW3NCVkeHUh?=
DEL MnzVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfDTWM2OD1yLkG4OFUh|ryP M3XhbnNCVkeHUh?=
NCI-H1395 NVLHfoxUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjadVdKSzVyPUCuNVg3QDJizszN MkLBV2FPT0WU
JEG-3 M2PYOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPMTWM2OD1yLkG4O|A2KM7:TR?= NGXkRnJUSU6JRWK=
BCPAP NHfNNG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzifpkzUUN3ME2wMlE5QDd{IN88US=> MmPaV2FPT0WU
CAL-27 MkXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37YSGlEPTB;MD6xPVAzOiEQvF2= M4THUHNCVkeHUh?=
RD NYfIXJh1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHWSldDUUN3ME2wMlE6OTF|IN88US=> NWntdlFVW0GQR1XS
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COLO-680N NHjyUnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nlZWlEPTB;MD6xPVM3PCEQvF2= NE[5UFJUSU6JRWK=
NCI-H1650 NEjiNZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTBwMkCwOVch|ryP NX3NNlh7W0GQR1XS
SBC-5 M1LVSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTHb3d3UUN3ME2wMlIxOTF6IN88US=> NXzqSGVKW0GQR1XS
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S-117 M4TmV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;sTFJmUUN3ME2wMlIxPTZ2IN88US=> MYfTRW5ITVJ?
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AM-38 M2nEbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HJU2lEPTB;MD6yNFg1QCEQvF2= M4WzU3NCVkeHUh?=
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HPAF-II M1jtU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jyPWlEPTB;MD6yNVI3PCEQvF2= M3n0d3NCVkeHUh?=
769-P MnjkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HrR2lEPTB;MD6yNVI5KM7:TR?= NH;jdZBUSU6JRWK=
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TE-9 M1PxZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jteWlEPTB;MD6yNVc5PiEQvF2= NXzhe|NLW0GQR1XS
C2BBe1 NX7nc|Y3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwMkKxPUDPxE1? NWPyTpZ7W0GQR1XS
EoL-1-cell MkDZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrQXGFKSzVyPUCuNlIzODNizszN Mlz4V2FPT0WU
G-361 M2jwW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjtTWM2OD1yLkKyOlgzKM7:TR?= NF73TYlUSU6JRWK=
KYSE-270 M2ToRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPXTWM2OD1yLkKzNFg1KM7:TR?= NU\rW21tW0GQR1XS
TK10 M3zWS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwMkOxNVch|ryP M3fTV3NCVkeHUh?=
ML-2 MkfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTBwMkOxNVkh|ryP MlW2V2FPT0WU
MHH-ES-1 NGL6O4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXYTWM2OD1yLkKzOlgyKM7:TR?= M1TYTHNCVkeHUh?=
BHY NFjmNFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEn0T2NKSzVyPUCuNlM3QTFizszN NVnUeVdTW0GQR1XS
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NCI-H1355 MnzJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PlXWlEPTB;MD6yPFA4PCEQvF2= M4PSNHNCVkeHUh?=
NCI-H1048 MnXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfMXY5pUUN3ME2wMlI5QTV4IN88US=> NF21[5BUSU6JRWK=
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HCC38 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwM{CwO|gh|ryP MXjTRW5ITVJ?
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KYSE-70 MoXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWK2foRPUUN3ME2wMlM{Ojh|IN88US=> MUHTRW5ITVJ?
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A3-KAW MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TpfmlEPTB;MD6zOFE3OiEQvF2= MoHEV2FPT0WU
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NCI-H2405 MmmxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHO0PWJKSzVyPUCuN|Q3OzFizszN Mo\CV2FPT0WU
NCI-H2228 MmTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TrbGlEPTB;MD6zOVM2PyEQvF2= NVTyTXhRW0GQR1XS
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PANC-10-05 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwNEGxO{DPxE1? MkjDV2FPT0WU
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TE-10 M3LpfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXITWM2OD1yLkSxOFQ4KM7:TR?= NFzCSVRUSU6JRWK=
HOS MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTBwNEG2PFIh|ryP NH3wNWFUSU6JRWK=
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CAL-12T MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwNEK3PEDPxE1? NEHoPFJUSU6JRWK=
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HOP-62 NHjoc2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\FcI9SUUN3ME2wMlQ6QDZ3IN88US=> MYPTRW5ITVJ?
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PANC-08-13 NE\XSolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrOOldEUUN3ME2wMlU{OTd5IN88US=> M4DzT3NCVkeHUh?=
CAL-120 NIricJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnVfZdkUUN3ME2wMlU{Ozl7IN88US=> MnjMV2FPT0WU
UMC-11 NFi4fZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnV[lFPUUN3ME2wMlU2OjN2IN88US=> MXjTRW5ITVJ?
MSTO-211H MlXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojZTWM2OD1yLkW1O|YzKM7:TR?= MljDV2FPT0WU
NCI-H2126 NHf6R4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\COmlEPTB;MD61OlgyPSEQvF2= NE\iTnRUSU6JRWK=
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DBTRG-05MG M4PPXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnixTWM2OD1yLkW4NFU{KM7:TR?= M4jJbnNCVkeHUh?=
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OVCAR-3 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTBwNUmzOFEh|ryP MnS3V2FPT0WU
ACHN Mn;HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPGTWM2OD1yLk[wOVY6KM7:TR?= NEf6TVhUSU6JRWK=
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NCI-H661 Mn3KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mle4TWM2OD1yLk[xNVA1KM7:TR?= NYDyUm5PW0GQR1XS
UACC-893 MlvSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHmTWM2OD1yLk[zOlgyKM7:TR?= Ml;yV2FPT0WU
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SF268 NXr5cHFPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;5V2lEPTB;MD62OFM1QSEQvF2= M{DjVXNCVkeHUh?=
OCI-AML2 M1\BTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TLcWlEPTB;MD62OVM6PyEQvF2= M2\UTnNCVkeHUh?=
RPMI-8226 MnjNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTBwNk[zNlMh|ryP MkDSV2FPT0WU
MKN28 NIjPdJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nBSGlEPTB;MD62OlYzPCEQvF2= NV23T41MW0GQR1XS
MDA-MB-453 NVOwOW56T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnaO4l{UUN3ME2wMlY4OThizszN MYTTRW5ITVJ?
BV-173 NX;QS2hCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2i3XWlEPTB;MD62PFY4QSEQvF2= M{fHSHNCVkeHUh?=
NCI-H358 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWq0PWZ6UUN3ME2wMlY5PzJ4IN88US=> MmrTV2FPT0WU
NCI-H1651 M2fVN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkC5TWM2OD1yLkeg{txO MnHYV2FPT0WU
MDA-MB-415 NYOzU|hXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELn[JRKSzVyPUCuO|A5OjlizszN NVO2[|A4W0GQR1XS
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EFM-19 MmPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXG3XItHUUN3ME2wMlc{PjdzIN88US=> MX\TRW5ITVJ?
RERF-LC-MS M2TGS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoruTWM2OD1yLke0OlE{KM7:TR?= M1rwUXNCVkeHUh?=
A388 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULs[pNvUUN3ME2wMlc3PDZ5IN88US=> NIrTWJBUSU6JRWK=
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IGR-1 NHTvOXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITlenBKSzVyPUCuO|kxPDNizszN MmnhV2FPT0WU
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SK-MEL-3 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDlTWM2OD1yLkixOVA5KM7:TR?= NGP4PYVUSU6JRWK=
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LS-1034 M3rQcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTVwNEKzNFch|ryP NIjJPYZUSU6JRWK=
GR-ST M4XRSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTVwNUKyNFEh|ryP M4nrUHNCVkeHUh?=
NCI-H1092 NUnQTYQzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTsPGQxUUN3ME21MlczQDR|IN88US=> NV3vcIk1W0GQR1XS
647-V NFnP[|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFftbGhKSzVyPUWuO|Q4ODZizszN NH3lWW9USU6JRWK=
EW-13 NYTQdGNGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlz2TWM2OD13Lke2OlI4KM7:TR?= M1PvbHNCVkeHUh?=
KGN MmHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfPTWM2OD14LkC5PVIyKM7:TR?= M{e3enNCVkeHUh?=
D-423MG NUfwSpJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1yzSmlEPTB;Nj60NFI5PCEQvF2= NFq1WHRUSU6JRWK=
ECC10 NWPpSZNMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUj3OG5TUUN3ME23MlExOTBzIN88US=> M37mSXNCVkeHUh?=
TE-5 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M123U2lEPTB;Nz60NVI6QCEQvF2= M3;1cXNCVkeHUh?=
P12-ICHIKAWA MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoP1TWM2OD15LkS1OVI{KM7:TR?= M3nOb3NCVkeHUh?=
NCI-H82 M3jiUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILTTFVKSzVyPUeuOFU4ODFizszN MYDTRW5ITVJ?
NCI-H1993 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV:xTGt4UUN3ME23Mlg{ODZ|IN88US=> MnuxV2FPT0WU
RH-1 NH;leHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3mTWM2OD15Lki1NlQ1KM7:TR?= NXjk[HhOW0GQR1XS
SW948 NV3xZo9vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTdwOU[wOFkh|ryP MVvTRW5ITVJ?
CAL-33 M1nFZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPsTWM2OD15Lkm5PVM5KM7:TR?= NHPMN3dUSU6JRWK=
U-266 NInlSpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjhUGRKSzVyPUiuNVU4PzdizszN M1rXNnNCVkeHUh?=
CAL-72 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjPfmlKSzVyPUiuNlA{OiEQvF2= M4\GOnNCVkeHUh?=
SNU-423 Mor6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mom2TWM2OD17LkO2OlY3KM7:TR?= NFnCUXJUSU6JRWK=
KG-1 MmD6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjo[IQ5UUN3ME25MlU5PDV4IN88US=> M1O5T3NCVkeHUh?=
HCC1395 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXWZolqUUN3ME25MlkzOzV{IN88US=> NYH3[ZdoW0GQR1XS
BE-13 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnVTWM2OD1zMD64PFkzKM7:TR?= NFXkO3lUSU6JRWK=
MKN7 M1qyZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TieWlEPTB;MUCuPVc3PSEQvF2= NW\hTHRbW0GQR1XS
697 NYD4XXRrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moe4TWM2OD1zMT6xOFczKM7:TR?= M1zJW3NCVkeHUh?=
LU-135 M3vxTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HLRmlEPTB;MUGuNlMxPyEQvF2= MlHQV2FPT0WU
ES7 MknNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTFzLkOzNVMh|ryP M3\6XnNCVkeHUh?=
SK-HEP-1 M13mV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEP0WW5KSzVyPUGxMlc3PDZizszN MWrTRW5ITVJ?
BEN MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nVZmlEPTB;MUGuPFUyKM7:TR?= MVzTRW5ITVJ?
NCI-H1770 NIGxNG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVSyWpZIUUN3ME2xNk4yOjZizszN MkH6V2FPT0WU
SW13 M3;1WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTF{LkG1OFEh|ryP NYL5fGRoW0GQR1XS
MZ1-PC M3fsUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4[wemlEPTB;MUKuOVQ2OiEQvF2= NYXOV3hUW0GQR1XS
Mo-T NYnWUGRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrDTWM2OD1zMj63OFIyKM7:TR?= NFn4S2NUSU6JRWK=
HLE NVXvd2VyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPKdFUyUUN3ME2xNk45OjF3IN88US=> M3S3b3NCVkeHUh?=
RCC10RGB NV\WboZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHubopKSzVyPUGzMlY4OSEQvF2= MVLTRW5ITVJ?
COLO-320-HSR NHK3ZnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXycJU{UUN3ME2xN{44OzhzIN88US=> M3vC[3NCVkeHUh?=
BHT-101 MnTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\MTWM2OD1zMz64N|Q2KM7:TR?= NWfoVFJPW0GQR1XS
OCUB-M MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLhWmJFUUN3ME2xOE4yPjB{IN88US=> MVPTRW5ITVJ?
MEG-01 M2n5Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4f5bmlEPTB;MUSuN|cxQCEQvF2= NWPQPY46W0GQR1XS
RS4-11 MnHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\wOmlEPTB;MUSuO|QzKM7:TR?= M2KzNnNCVkeHUh?=
MN-60 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4q1d2lEPTB;MUSuO|g6PCEQvF2= MXLTRW5ITVJ?
NCI-H1304 NHXxRW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnr3TWM2OD1zNT6wOFI2KM7:TR?= NHrYbHZUSU6JRWK=
Ramos-2G6-4C10 NH7Z[YxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fuTGlEPTB;MUWuNFU5OSEQvF2= NELaSpVUSU6JRWK=
NCI-H2342 NWjZ[WJiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfGOoJKSzVyPUG1MlIxPDRizszN MUPTRW5ITVJ?
LAN-6 NVzubIxPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XqfWlEPTB;MUWuOFQyPCEQvF2= MkTIV2FPT0WU
JVM-2 M{DLSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jufWlEPTB;MUWuOVc1QCEQvF2= M2W5fHNCVkeHUh?=
P30-OHK MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\kOWFKSzVyPUG2MlA3OTRizszN M2rYW3NCVkeHUh?=
C-33-A MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPxW4JKSzVyPUG2MlYzOTRizszN NEHWbotUSU6JRWK=
RPMI-8866 MnzWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mly2TWM2OD1zNj64OFk3KM7:TR?= MnL3V2FPT0WU
NCI-H630 NGC2bpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\SXnA5UUN3ME2xOk45PTN5IN88US=> NEj1b5pUSU6JRWK=
KYSE-140 NVTwd4x3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LFRmlEPTB;MUeuNlAzQCEQvF2= Mkm4V2FPT0WU
T84 M2LVbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHLOFJKSzVyPUG4Mlg3QTVizszN MYrTRW5ITVJ?
KU-19-19 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTF6Lkm2NFgh|ryP M1XWXHNCVkeHUh?=
BALL-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTF7LkOzPVkh|ryP MlzHV2FPT0WU
Calu-6 M2TTXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofYTWM2OD1zOT60PVIh|ryP M1mxN3NCVkeHUh?=
EGI-1 NUflN|FOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDnTWM2OD1zOT61PVgh|ryP NYqxTnRmW0GQR1XS
MFH-ino MlfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYr0[Yt1UUN3ME2xPU44PDV2IN88US=> M2HhUnNCVkeHUh?=
GB-1 NULQS3RJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFva[mxKSzVyPUKwMlM2OzVizszN NWrDW4dlW0GQR1XS
NCI-H1693 MkLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXRR4FKSzVyPUKwMlY2ODVizszN MYfTRW5ITVJ?
SW1116 NF3YfJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTJyLkmzOlIh|ryP MX\TRW5ITVJ?
H-EMC-SS MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jEOmlEPTB;MkKuNFQ2KM7:TR?= MV7TRW5ITVJ?
D-502MG MmLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nJbGlEPTB;MkKuPFI3OSEQvF2= M33GbnNCVkeHUh?=
IA-LM MnG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{D6OGlEPTB;MkOuNlQ6OyEQvF2= M2PmeXNCVkeHUh?=
SW1463 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXGeGRrUUN3ME2yN{44QSEQvF2= NIHH[ZNUSU6JRWK=
JAR NEezVIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrqTWM2OD1{ND6zNlk{KM7:TR?= NIDybWpUSU6JRWK=
HT M3\WS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXnWGhtUUN3ME2yOE41PzV|IN88US=> M{nH[XNCVkeHUh?=
LCLC-103H NGXENVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTJ2Lki0OFkh|ryP M{DEenNCVkeHUh?=
SNU-449 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;h[GlEPTB;MkSuPFc1OSEQvF2= NH3EWWFUSU6JRWK=
KE-37 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTJ3LkC5Nlgh|ryP NX7udpg{W0GQR1XS
NCI-H1623 M4n0Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXT5RYZHUUN3ME2yO{4yOzB|IN88US=> NU[ydlBQW0GQR1XS
MOLT-13 MnXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjzdYpKSzVyPUK3MlM2OTZizszN NVv2RYdTW0GQR1XS
COLO-741 M17abWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWL0VXBbUUN3ME2zNU4{OzN|IN88US=> NELhUnNUSU6JRWK=
NB6 NHW3VlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTN{LkK4O|Yh|ryP NVvwUlMzW0GQR1XS
MOLT-16 NFHOU2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPsN4xKSzVyPUOzMlAxPTVizszN MnO2V2FPT0WU
IST-MES1 NVnIPIQ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDqU3FKSzVyPUO0MlA2PDFizszN NHqxOohUSU6JRWK=
A4-Fuk Mn\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\hWmlEPTB;M{WuNFY3KM7:TR?= NGLyNopUSU6JRWK=
CAL-85-1 M2LhWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DYRmlEPTB;M{WuNlgyPyEQvF2= NV3VN2h6W0GQR1XS
CCRF-CEM MmXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUP6WlhEUUN3ME2zO{4yPTN4IN88US=> MWDTRW5ITVJ?
HAL-01 M{C3U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfvboR2UUN3ME2zPE41QDh7IN88US=> MVjTRW5ITVJ?
HEL NHrHeW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTR|LkO0NFkh|ryP M{nYcXNCVkeHUh?=
EW-1 M1[1Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTR|LkS3Olgh|ryP M2rE[HNCVkeHUh?=
MDA-MB-231 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jSe2lEPTB;NEWuNVE6QSEQvF2= NHLvPVJUSU6JRWK=
ABC-1 NEnVcZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXsTWM2OD12Nj64OVM5KM7:TR?= MVvTRW5ITVJ?
NCI-H446 NGXi[YJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jvSmlEPTB;NEiuOVA2QCEQvF2= MU\TRW5ITVJ?
MHH-PREB-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLzWYR4UUN3ME20PU43ODB5IN88US=> Ml3iV2FPT0WU
DOHH-2 NEm2TXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTR7Lk[2OVYh|ryP NUDV[mh{W0GQR1XS
GCT Mk\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXTTWM2OD12OT62PVc3KM7:TR?= MVzTRW5ITVJ?

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
α-Synuclein / HSP90 / HSP70 / HSP32 / αB-Crystallin; 

PubMed: 20090920     


Immunoblot analysis of heat shock protein induction. Cells were treated with 17-AAG (1–200 nM, 24 h), or subjected to heat shock (HS: 44°C, 30 min, 24 h recovery) or to MG-132 (MG: 1 µM, 24 h). Cell lysates were prepared and immunoblot analysis was carried out with antibodies against the individual proteins as indicated on the right. Co, untreated control.

EGFR / PDGFR / AKT / MAPK / c-RAS; 

PubMed: 18682579     


17-AAG promotes the degradation of HSP90 client proteins that are involved in the pathology of glioblastoma multiforme (GBM). Glioma cell lines were treated with increasing concentrations of 17-AAG for 48 h, and protein lysates were run on Western blots. HSP90 client proteins known to be involved in gliomagenesis showed degradation while nonclient proteins remained unaffected by 17-AAG treatment.

pAKT / pMAPK / pRb; 

PubMed: 18682579     


The phosphorylated states of signaling proteins involved in glioma growth are also affected by 17-AAG treatment.

Cleaved PARP / Survivin; 

PubMed: 18827603     


Western analysis of expression levels of cleaved PARP and Survivin in MM cell lines. β-Actin served as loading control.

LATS1 / p-LATS1 / YAP / CTGF; 

PubMed: 25712415     


Effects of 17-AAG on the expression of LATS1, p-LATS1, YAP and CTGF.  The expression levels of YAP and CTGF proteins, indicated by Western blot assay, were down-regulated, while LATS1 was upregulated in a dose-dependent manner in 17-AAG treated groups compared to the untreated group.

20090920 18682579 18827603 25712415
Immunofluorescence
STAT3; 

PubMed: 27279418     


Effects of 17-AAG on STAT3 expression of H446 cells. (A) Control group; (B) 3.125 mg/l; (C) 6.25 mg/l. 17-AAG, 17-allylamino-17-demethoxygel-danamycin; STAT3, signal transducer and activator of transcription 3; DAPI, 4′,6-diamidino-2-phenylindole.

YAP / TAZ; 

PubMed: 25290150     


Reduction in cytoplasmic distribution accompanied by increased nuclear localization of YAP/TAZ was more apparent in cells treated with 45 nM 17-AAG (red channel for YAP/TAZ and blue channel for nucleus). Statistical comparisons were performed using one-way Kruskal-Wallis multiple comparison, ***p<0.001 compared with control (0 nM).

β-catenin / E-cadherin; 

PubMed: 25290150     


Co-localization of β-catenin (Red) and E-cadherin (Green) was observed at the cell-cell junctions (white arrows) both in siCtrl and siCTGF cells after 17-AAG treatment. Scale bar is 20 µm.

27279418 25290150
Growth inhibition assay
Cell viability; 

PubMed: 18682579     


17-AAG inhibits the growth of human glioma cell lines. Human glioma cell lines and a nontumorigenic fibroblast cell line were treated with increasing concentrations of 17-AAG for 4 days, and the effect on cell growth was assessed by a 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt (MTS) assay. The 50% inhibitory concentration (IC50) of all glioma cell lines ranged from 0.05 to 0.5 μM 17-AAG, as compared to 1.5 μM for the nontumorigenic cells.

18682579
体内研究 17-AAG作用于携带3T3-src, B16或CT26移植瘤裸鼠,与Hsp90结合具有高亲和力,IC50为8-35 nM,而作用于正常组织时,IC50为200-600 nM。[1] 17-AAG按50 mg/kg左右剂量处理,引起AR, HER2, HER3, 和 Akt表达明显降低,降低达50%以上,这种作用存在剂量依赖性,结果导致雄激素依赖型 (CWR22)和非依赖型(CWR22R 和CWRSA6) 前列腺移植瘤生长受抑制,抑制率分别为67%, 80%和 68%。[2]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[1]
+ 展开

Hsp90结合实验:

纯化的Hsp90蛋白或过量表达HER-2的癌细胞(BT474, N87, SKOV3 和 SKBR3) 裂解物或BT474乳腺癌细胞溶于溶解buffer(20 mM HEPES, pH 7.3, 1 mM EDTA, 5 mM MgCl2, 100 mM KCl) ,与不同浓度17-AAG在4oC下温育30分钟,然后和生物素-GM链接的BioMag链霉亲和素磁珠在4oC下温育1小时。试管放置于磁架上,除去未结合的上清液。在溶解buffer中清洗三次磁珠,然后在SDS–PAGE 样本缓冲液中在95oC下加热5分钟。在SDS蛋白凝胶上进行样本分析,使用特点抗体进行Western Blotting。使用Bio-rad Fluor-S 多重图像测量Western Blot条带,计算抑制Hsp90与生物素-GM结合的百分数。测定IC50。
细胞实验:[1]
+ 展开
  • Cell lines: BT474, SKBR3, N87, SKOV3, MCF7, MDA468, Hs578T, Hs578Bst, A549, HT29, U87, SKMG3, HT1080, RPTEC, NDF, HMVEC, HMEC, HUVEC, 和 PBMC
  • Concentrations: 溶于DMSO, 终浓度为10 μM 左右
  • Incubation Time: 5天
  • Method: 细胞按每孔2000个接种在96孔板上,终培养体积为100 μL,培养24小时, 然后加入浓度不断增高的17-AAG,温育5天。使用 Celltiter 96 AQueous 非放射性细胞增殖检测试剂盒测定存活细胞数。测定IC50。
    (Only for Reference)
动物实验:[2]
+ 展开
  • Animal Models: 皮下注射雄激素依赖性CWR22移植瘤的雄性 nu/nu 无胸腺小鼠, 皮下注射雄激素非依赖性的CWR22R和CWRSA6移植瘤的雌性nu/nu 无胸腺小鼠。
  • Formulation: 溶于DMSO, 对照组用蛋磷脂(EPL)稀释
  • Dosages: 50 mg/kg 左右
  • Administration: 腹膜注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 100 mg/mL (170.73 mM)
Ethanol 5 mg/mL (8.53 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5%DMSO+corn oil
10mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 585.69
化学式

C31H43N3O8

CAS号 75747-14-7
储存条件 powder
in solvent
别名 CP127374,NSC-330507, KOS 953

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00103272 Terminated Adult Acute Basophilic Leukemia|Adult Acute Eosinophilic Leukemia|Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Nodal Marginal Zone B-cell Lymphoma|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult T-cell Leukemia/Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Refractory Chronic Lymphocytic Leukemia|Small Intestine Lymphoma|Splenic Marginal Zone Lymphoma|Waldenström Macroglobulinemia National Cancer Institute (NCI) April 2005 Phase 1
NCT00098488 Terminated B-cell Chronic Lymphocytic Leukemia|Prolymphocytic Leukemia|Refractory Chronic Lymphocytic Leukemia National Cancer Institute (NCI) April 2005 Phase 1
NCT00118248 Completed Recurrent Thyroid Cancer|Stage IV Follicular Thyroid Cancer|Stage IV Papillary Thyroid Cancer|Thyroid Gland Medullary Carcinoma National Cancer Institute (NCI) December 2004 Phase 2
NCT00098423 Completed Accelerated Phase Chronic Myelogenous Leukemia|Adult Acute Basophilic Leukemia|Adult Acute Eosinophilic Leukemia|Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Blastic Phase Chronic Myelogenous Leukemia|Chronic Myelomonocytic Leukemia|de Novo Myelodysplastic Syndromes|Previously Treated Myelodysplastic Syndromes|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia|Refractory Anemia With Excess Blasts in Transformation|Relapsing Chronic Myelogenous Leukemia|Secondary Acute Myeloid Leukemia|Secondary Myelodysplastic Syndromes National Cancer Institute (NCI) November 2004 Phase 1

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操作手册

如果有其他问题,请给我们留言。

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常见问题及建议解决方法

  • 问题 1:

    What kind of subtypes does this compound inhibit? HSP90α or HSP90β ?

  • 回答:

    17-AAG can inhibit both HSP90α and HSP90β, but it is unclear how much are they affected respectively. You should note that Hsp90 derived from tumor cells has a 100-fold higher binding affinity for 17-AAG than that from normal cells according to this paper. http://www.nature.com.ezp-prod1.hul.harvard.edu/nature/journal/v425/n6956/full/nature01913.html

HSP (e.g. HSP90) Signaling Pathway Map

HSP (e.g. HSP90) Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID