Fluorouracil (5-Fluorouracil, 5-FU)

For research use only. Not for use in humans.

目录号:S1209 别名: NSC 19893 中文名称:氟尿嘧啶

Fluorouracil (5-Fluorouracil, 5-FU) Chemical Structure

CAS No. 51-21-8

Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) 是DNA/RNA合成抑制剂,在肿瘤细胞中通过抑制胸苷酸合成酶(TS)而干扰核苷酸合成。Fluorouracil 可诱导细胞凋亡并可用于治疗HIV。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1091.79 现货
RMB 1187.43 现货
RMB 1799.08 现货
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客户使用Selleck生产的Fluorouracil (5-Fluorouracil, 5-FU)发表文献149篇:

产品安全说明书

DNA/RNA Synthesis抑制剂选择性比较

生物活性

产品描述 Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) 是DNA/RNA合成抑制剂,在肿瘤细胞中通过抑制胸苷酸合成酶(TS)而干扰核苷酸合成。Fluorouracil 可诱导细胞凋亡并可用于治疗HIV。
靶点
Thymidylate synthase [1]
(Tumor cells)
体外研究

Adrucil是一种尿嘧啶类似物,在C-5位置上有一个氟原子。利用和尿嘧啶一致的转运途径快速进入细胞。Adrucil在细胞内转化成几个活性代谢物:氟脱氧尿苷单磷酸盐(FdUMP),氟脱氧尿苷三磷酸盐(FdUTP) 以及氟尿苷三磷酸盐 (FUTP)。Adrucil的代谢物FdUMP结合到TS核苷酸结合位点,与CH2THF形成稳定的三聚体,进而阻断了正常的底物dUMP的结合,抑制了dTMP的合成。Adrucil代谢物能够插入DNA,导致DNA双链断裂和细胞死亡。Adrucil的促凋亡作用可能和激活肿瘤抑制因子P53有关。P53功能缺失降低细胞对Adrucil的敏感性。[1]Adrucil抑制存活诱导各种细胞的凋亡。Adrucil 抑制鼻咽癌细胞系CNE2 和 HONE的生存能力[2],Adrucil抑制Capan-1细胞的生存能力[3],Adrucil抑制HT-29细胞的生存能力[4],IC50 分别是 9 μg/mL, 3 μg/mL, 0.22 μM, 2.5 μM。

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H292 NITGPYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTqNJU4OsLiaNMg NITxTZRKSzVyPjCyOUDPxGdxbVy= NHHCS3A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC5OVE4Pid-MkSwPVUyPzZ:L3G+
HL-60 M1P6bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjLNok4OsLiaNMg M{Hz[GlEPTB;OD62NFEh|rypL33M MlvwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyOUWxO|YoRjJ2MEm1NVc3RC:jPh?=
HT-29 M{fHR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TCUVczyqCqwrC= NVzmfXZoUUN3ME6gNlUh|rypL33M NWT2b3pYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwPVUyPzZpPkK0NFk2OTd4PD;hQi=>
MCF-7 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\4b3Y3PzMEoHlCpC=> NIOyTWpKSzVyPUKwJO69\y:vTB?= MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB7NUG3Okc,OjRyOUWxO|Y9N2F-
L1210/0 MUDGeY5kfGmxbjDhd5NigQ>? Mme1SYZn\WO2IH;uJGwyOjFyL{CgZ4VtdHNiaX6gZ5VtfHW{ZTygTWM2OCB;IECuN{DPxE1w NV\aZZN3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NlI4QCd-MkO2NlI4QDxxYU6=
CCRF-CEM NG\1RYFHfW6ldHnvckBie3OjeR?= MXLF[oZm[3Rib36gR2NTTi2FRV2gZ4VtdHNiaX6gZ5VtfHW{ZTygTWM2OCB;IEKg{txONg>? MnSxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MkK3PEc,OjN4MkK3PFww[T5?
P388 NEjUbnhCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= Mm\pOFghcHK| NHXa[4lCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIGCzPFgh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuOlA6KM7:TT6= NFzBSpo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e4OFQ6Lz5{N{e4OFQ6RC:jPh?=
HT-29 M3HWRmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NGTrdYg6PiCqcoO= NEfITllCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjUMVI6KGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlY6KM7:TT6= MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd6NES5K|4zPzd6NES5QE9iRg>?
L1210 MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4jpbWlvcGmkaYTpc44hd2ZiY3XscEBoem:5dHigc4YhVDF{MUCgcY92e2ViTHX1b4VucWFiY3XscJMtKEmFNUCgQUAxNjNizszNMi=> NYW1XmJbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2O|M4PSd-Mkm2O|M4PTxxYU6=
L1210 NGXhTJdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mk\NR49v[2WwdILheIlwdiC{ZYH1bZJm\CCob4KgeIhmKDVyJTDpcohq[mm2aX;uJI9nKGe{b4f0bEBw\iCOMUKxNEBud3W|ZTDs[ZVs\W2rYTDj[YxteyCrbjDjeYx1fXKnLDDJR|UxKD1iMD61JO69VS5? MoXWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwPzF{MEK5NEc,PzF{MEK5NFww[T5?
CCRF-CEM NYfHR|JCT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEHGWW1Ed26lZX70doF1cW:wIILldZVqemWmIH\vdkB1cGViNUClJIlvcGmkaYTpc44hd2ZiZ4Lve5RpKG:oIFPDVmYuS0WPIHj1cYFvKGyndXvlcYliKGOnbHzzJIlvKGO3bIT1doUtKEmFNUCgQUA2KM7:TT6= NXnrNFNWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxN{GyNFI6OCd-N{GyNFI6ODxxYU6=
L1210 NWnsXIp[T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGS0O3A1QCCqcoO= M3:4d2lvKH[rdILvJIdzd3e2aDDpcohq[mm2aX;uJI9nKExzMkGwJINmdGy|IES4JIhwfXK|IHHmeIVzKGGmbXnubZN1emG2aX;uJI9nKGOxbYDveY5lNCCLQ{WwJF0hOC5zMjFOwG0v MlrBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwPzZ{OUiwOkc,PzZ{OUiwOlww[T5?
L1210 M1rSU2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVuyOEBpenN? MVTJckB3cXS{bzDndo94fGhiaX7obYJqfGmxbjDv[kBNOTJzMDDj[YxteyB{NDDoc5VzeyCjZoTldkBi\G2rbnnzeJJifGmxbjDv[kBkd22yb4Xu[EwhUUN3MDC9JFAvOjJizszNMi=> M3nyZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzd4Mkm4NFYoRjd4Mkm4NFY9N2F-
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L1210 NFz0OHRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWHycnZFOiCqcoO= MmDnTY4hfmm2cn:g[5Jwf3SqIHnubIljcXSrb36gc4YhVDF{MUCgZ4VtdHNiMjDoc5VzeyCjZoTldkBi\G2rbnnzeJJifGmxbjDv[kBkd22yb4Xu[EwhUUN3MDC9JFIvOiEQvF2u M{jwb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzd4Mkm4NFYoRjd4Mkm4NFY9N2F-
CHO MnHvS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NU\TUFluT3Kxd4ToJIlvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBEUE9iY3XscJMhcW5iY4XseJVz\S5uIFnDOVAhRSB3IN88UU4> Ml[xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwPzh3M{O0Nkc,Pzh3M{O0Nlww[T5?
SCLC MoDWR5l1d3SxeHnjbZR6KGG|c3H5 MVHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTR2xEKGOnbHzzJJJme2m|dHHueEB1dyClaYPwcIF1cW5iKGPDUGMwS0SGUDmsJGlEPTBiPTC4MlQh|ryPLh?= MkDNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQDJ3OEizOUc,QDJ3OEizOVww[T5?
T-24 NXLqPGpbS3m2b4TvfIlkcXS7IHHzd4F6 Mn;PWIV{fGWmIH\vdkBkgXSxdH;4bYNqfHliYXfhbY5{fCCjboTp[4VvKG6nZ3H0bZZmKFRvMkSgZoxi\GSncjDjZZJkcW6xbXGgZ4VtdHNiaHH2bY5oKG:wbImgN{02LSCjboTp[4VvKGW6cILld5Nqd25uIFnDOVAhRSB2LkGg{txONg>? MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek85PDl4OUK2K|45PDl4OUK2QE9iRg>?
791T NEnHeJVEgXSxdH;4bYNqfHliYYPzZZk> MWPU[ZN1\WRiZn;yJIN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGGwdHnn[Y4heG:|aYTpeoUhPzlzVDDvd5Rmd3OjcnPvcYEh[2WubIOgbIF3cW6pIH;ucJkhOy13JTDhcpRq\2WwIHX4dJJme3Orb36sJGlEPTBiPTC1MlUh|ryPLh?= NILqWm49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi96NEm2PVI3Lz56NEm2PVI3RC:jPh?=
9L MnnORY51cWOjbnPldkBie3OjeR?= MXHU[ZN1\WRiaX6geol1em9iZn;yJIFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEA6VCClZXzsd{whUUN3MDC9JFEh|ryPLh?= M3TSelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyMEeyOlg{Lz5zMEC3NlY5OzxxYU6=
SK-MEL-28 MnfHRY51cWOjbnPldkBie3OjeR?= M{DJW3Rme3SnZDDpckB3cXS{bzDmc5Ih[W62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KFONLV3FUE0zQCClZXzsd{whUUN3MDC9JFQvPSEQvF2u MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODB5Mk[4N{c,OTByN{K2PFM9N2F-
PBM NITON|JEgXSxdH;4bYNqfHliYYPzZZk> NUHqS4Z5XGW|dHXkJIlvKH[rdILvJIZweiCleYTveI95cWOrdImgZYdicW6|dDDQRm0h[2WubIOsJGlEPTBiPTC1JO69VS5? NUXXeJVzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUCwO|I3QDNpPkGwNFczPjh|PD;hQi=>
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SK-MES-1 MVjBcpRq[2GwY3XyJIF{e2G7 MkPPWIV{fGWmIHnuJJZqfHKxIH\vdkBidnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhW0tvTVXTMVEh[2WubIOsJGlEPTBiPTCxN{4yKM7:TT6= M2DiR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyMEeyOlg{Lz5zMEC3NlY5OzxxYU6=
HepG2 MYnBcpRq[2GwY3XyJIF{e2G7 NIL2[FZV\XO2ZXSgbY4hfmm2cn:g[o9zKGGwdHnjZY5k\XJiYXP0bZZqfHliYXfhbY5{fCCKZYDHNkBk\WyuczygTWM2OCB;IEO3Mlkh|ryPLh?= MkTPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTByN{K2PFMoRjFyMEeyOlg{RC:jPh?=
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Molt 4/C8 MknrS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUe4Z2QxS2:wY3XueJJifGmxbjDy[ZF2cXKnZDD0c{BqdmirYnn0JFUxLSCxZjDj[YxtKGe{b4f0bEBwdiCqdX3hckBOd2y2IESvR|gh[2WubIOuMEBKSzVyIE2gNlMh|ryPLh?= M{nr[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzMEWyO|k5Lz5zMUC1Nlc6QDxxYU6=
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NCI-H522 M3fRRmFvfGm2dX3vdkBie3OjeR?= NV;Rdod2SW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUmNKNUh3MkKgZ4VtdHNuIFfJOVAhRSB|OT64NVA4KM7:TT6= NUToPY5ERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0OFYxPzdpPkG3OFQ3ODd5PD;hQi=>
NCI/ADR-RES MnnhRY51cXS3bX;yJIF{e2G7 NFLib4FCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOR2kwSUSULWLFV{Bk\WyuczygS2k2OCB;IEO5MlgyODdizszNMi=> M4P4bVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NES2NFc4Lz5zN{S0OlA4PzxxYU6=
SW480 MU\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M2XydVczKGi{cx?= M1vu[mFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iU2e0PFAh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBu\XSqb3SsJGlEPTBiPTC4MlEh|ryPLh?= MmDpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3MkS2OVUoRjF5NUK0OlU2RC:jPh?=
MDA-MB-435S M{PEUWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M1Pje|czKGi{cx?= MknURY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRFGtUWIuPDN3UzDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIH3leIhw\CxiSVO1NEA:KDF2LkWg{txONg>? MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzV{NE[1OUc,OTd3MkS2OVU9N2F-
HCCLM7 MULBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NVLreo9IPzJiaILz NYXsRpJqSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIR2NNVTdiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCvZYToc4QtKEmFNUCgQUAyQC54IN88UU4> NGPSeGM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{WyOFY2PSd-MUe1NlQ3PTV:L3G+
Caco-2 MoDoS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{\BNWdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGNi[29vMjDj[YxteyxiSVO1NEA:KDFwNTFOwG0v MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzV2OEGyPUc,OTd3NEixNlk9N2F-
MCF7 NV7qV25TSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NXy2elNTPzJiaILz NVj2foFvSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEeyJIhzeyxiSVO1NEA:KDBwMzFOwG0v NH\FTY09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{W0PFE6QCd-MUe1OFgyQTh:L3G+
HCT116 NYKyOoNOSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NGXaNYE4OiCqcoO= MVXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEGxOkBk\WyuczDh[pRmeiB5MjDodpMtKEmFNUCgQUAzNjhizszNMi=> NFL4[|g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{W0PFE6QCd-MUe1OFgyQTh:L3G+
SW480 NXe3NGxOSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MXm3NkBpenN? NGXSNlNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPXOFgxKGOnbHzzJIFnfGW{IEeyJIhzeyxiSVO1NEA:KDNwNTFOwG0v NWTqUmJMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1OFgyQThpPkG3OVQ5OTl6PD;hQi=>
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DLD1 NIqyV4NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEn0[plIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBFVERzIHPlcIx{NCCLQ{WwJF0hPC53IN88UU4> MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzV3M{[4OUc,OTd3NUO2PFU9N2F-
Caco-2 Mn\KS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHXaV|cyOCCmYYnz MXLHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDDZYNwNTJiY3XscJMh[W[2ZYKgNVAh\GG7czygTWM2OCB;IEGuOUDPxE1w MmTIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3NUW5OlkoRjF5NUW1PVY6RC:jPh?=
colon cancer cell NF\Xd|NEgXSxdH;4bYNqfHliYYPzZZk> M3\NdGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJINwdG:wIHPhcoNmeiClZXzsd{whT0l3MDC9JFUvPzVizszNMi=> MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzV4MkO2OUc,OTd3NkKzOlU9N2F-
A549 NF7qOG1EgXSxdH;4bYNqfHliYYPzZZk> NXTyT5V6PDhiaILz MnnDR5l1d3SxeHnjbZR6KGGpYXnud5QhSTV2OTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hQS5{IN88UU4> NFfSSlE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[wOFM6PCd-MUe2NFQ{QTR:L3G+
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CEM MmLGR5l1d3O2YYTpZ{Bi[3Srdnn0fUBie3OjeR?= MmHmR5l1d3O2YYTpZ{Bi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFPFUUBk\WyuczygTWM2OCB;IEmg{txONg>? NVHnZ2JyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe5N|E5PjJpPkG3PVMyQDZ{PD;hQi=>
Molt4/C8 NEXkfWJEgXSxc4TheIlkKGGldHn2bZR6KGG|c3H5 NGfTcI5EgXSxc4TheIlkKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUY9tfDRxQ{igZ4VtdHNuIFnDOVAhRSB{MzFOwG0v NF7jXW49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{mzNVg3Oid-MUe5N|E5PjJ:L3G+
Caco-2 MWHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUCxNEBl[Xm| NGHROmlIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBE[WOxLUKgZ4VtdHNiYX\0[ZIhOTBiZHH5d{whUUN3MDC9JFEvPSEQvF2u M37UOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6MEO3NVk2Lz5zOECzO|E6PTxxYU6=
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HepG2 NHfRXnJEgXSxdH;4bYNqfHliYYPzZZk> NX7MUFNGS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNuIFnDOVAhRSBzOD63JO69VS5? MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDNyMkOzOkc,OTh|MEKzN|Y9N2F-
L1210 M4Lte2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 MnrhNkBl[Xm| NH7hXYhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFyxNlExKGOnbHzzJIFnfGW{IEKg[IF6eyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlY6KM7:TT6= M2DiVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NEK0NVU2Lz5zOESyOFE2PTxxYU6=
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HepG2 MnXWRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MnjaN{Bl[Xm| NHjIO3RCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IEOg[IF6eyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC5MlIh|ryPLh?= NX:3bWI2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0NlQyPTVpPkG4OFI1OTV3PD;hQi=>
CEM MmDlRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NYjxPFhmOyCmYYnz MUDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEOHTTDj[YxteyCjZoTldkA{KGSjeYOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hQS5{MzFOwG0v MofPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh2MkSxOVUoRjF6NEK0NVU2RC:jPh?=
WI38 MnfBR5l1d3SxeHnjbZR6KGG|c3H5 M2HTO|Mh\GG7cx?= NXfpemE5S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hX0l|ODDj[YxteyCjZoTldkA{KGSjeYOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTBizszNMi=> MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDR{NEG1OUc,OTh2MkSxOVU9N2F-
HeLa M4PTcWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M3TCXlMh\GG7cx?= NUfKRnVKSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIFnfGW{IEOg[IF6eyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxOkDPxE1w MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDR{NEG1OUc,OTh2MkSxOVU9N2F-
Molt4/C8 NWfxV2xrSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M4TaT|Mh\GG7cx?= NH35UIlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3vcJQ1N0N6IHPlcIx{KGGodHXyJFMh\GG7czDifUBOXFRiYYPzZZktKEmFNUCgQUAzOCEQvF2u MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDR{NEG1OUc,OTh2MkSxOVU9N2F-
colon 26-L5 MUjDfZRwfG:6aXPpeJkh[XO|YYm= Mm\XO|IhcHK| MXLDfZRwfG:6aXPpeJkh[WejaX7zeEBud3W|ZTDjc4xwdiB{Nj3MOUBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMD60OkDPxE1w NV:4bGNxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0OFAzOzNpPkG4OFQxOjN|PD;hQi=>
HeLa MUDDfZRwfG:6aXPpeJkh[XO|YYm= MkG3O|IhcHK| NYHjeJZzS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC55NzFOwG0v NWnuVXFGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0OFAzOzNpPkG4OFQxOjN|PD;hQi=>
LLC MWLDfZRwfG:6aXPpeJkh[XO|YYm= NELYRWM4OiCqcoO= MkKzR5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgUGxEKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyMlU6KM7:TT6= M2\nRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NESwNlM{Lz5zOES0NFI{OzxxYU6=
B16-BL6 NYLYdVRSS3m2b4TvfIlkcXS7IHHzd4F6 Mnv6O|IhcHK| MWnDfZRwfG:6aXPpeJkh[WejaX7zeEBud3W|ZTDCNVYuSkx4IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA2Njd6IN88UU4> MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDR2MEKzN{c,OTh2NECyN|M9N2F-
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K562 NXW3RXYyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnvBOFghcHK| NXfT[WhFT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUzV4MjDj[YxteyCjZoTldkA1QCCqcoOgZpkhe3WuZn;ybI9l[W2rbnWgRkBie3OjeTygS2k2OCB;IEOuOVQ5OTNizszNMi=> M1PFRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOEWwNlA1Lz5{MEi1NFIxPDxxYU6=
UACC257 NG\nbJRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXm0PEBpenN? MWDHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDVRWNEOjV5IHPlcIx{KGGodHXyJFQ5KGi{czDifUB{fWyob4Loc4RidWmwZTDCJIF{e2G7LDDHTVUxKD1iMz61OFgyOyEQvF2u NEHMPHA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEi1NFIxPCd-MkC4OVAzODR:L3G+
SNB19 MWHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{HlfFQ5KGi{cx?= NGm0foFIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBUVkJzOTDj[YxteyCjZoTldkA1QCCqcoOgZpkhe3WuZn;ybI9l[W2rbnWgRkBie3OjeTygS2k2OCB;IEOuPFAyQDlizszNMi=> NUnHUYU2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4OVAzODRpPkKwPFUxOjB2PD;hQi=>
OVCAR4 MmH5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlHSOFghcHK| MUfHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDPWmNCWjRiY3XscJMh[W[2ZYKgOFghcHK|IHL5JJN2dG[xcnjv[IFucW6nIFKgZZN{[XluIFfJOVAhRSB2LkS2Olg1KM7:TT6= NFr5SYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEi1NFIxPCd-MkC4OVAzODR:L3G+
MDA-MB-231 M1u1N2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHLCTG81QCCqcoO= MV\Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDR6IHjyd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGG|c3H5MEBIUTVyIE2gOk43ODZ7MzFOwG0v M2rHZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOEWwNlA1Lz5{MEi1NFIxPDxxYU6=
NCI-H522 MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NH3qfHQ1QCCqcoO= MlTwS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUmNKNUh3MkKgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[XO|YYmsJGdKPTBiPTC3MlI1PDN4IN88UU4> NYLDZlFmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4OVAzODRpPkKwPFUxOjB2PD;hQi=>
T47D Ml\yS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NF3admY1QCCqcoO= NEG3SlBIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBVPDeGIHPlcIx{KGGodHXyJFQ5KGi{czDifUB{fWyob4Loc4RidWmwZTDCJIF{e2G7LDDHTVUxKD1iOD6xNlg{OSEQvF2u MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODh3MEKwOEc,OjB6NUCyNFQ9N2F-
CCRF-CEM NEnudlRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWGzZ4lbPDhiaILz NInZWpNIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBES1KILVPFUUBk\WyuczDh[pRmeiB2ODDodpMh[nlic4Xs[o9zcG:mYX3pcoUhSiCjc4PhfUwhT0l3MDC9JFkvPzd{M{eg{txONg>? M2Pyb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOEWwNlA1Lz5{MEi1NFIxPDxxYU6=
Hs 578T MX3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mn;ROFghcHK| NXjjTWN3T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUHNiNUe4WEBk\WyuczDh[pRmeiB2ODDodpMh[nlic4Xs[o9zcG:mYX3pcoUhSiCjc4PhfUwhT0l3MDC9JFkvPzd{M{eg{txONg>? MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODh3MEKwOEc,OjB6NUCyNFQ9N2F-
BT549 MkfYS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXfKTWR{PDhiaILz MmO2S5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gRnQ2PDliY3XscJMh[W[2ZYKgOFghcHK|IHL5JJN2dG[xcnjv[IFucW6nIFKgZZN{[XluIFfJOVAhRSBzMD63NVUzKM7:TT6= NUTJUodmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4OVAzODRpPkKwPFUxOjB2PD;hQi=>
OVCAR5 NVrJRm5kT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3rVXVQ5KGi{cx?= MUPHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDPWmNCWjViY3XscJMh[W[2ZYKgOFghcHK|IHL5JJN2dG[xcnjv[IFucW6nIFKgZZN{[XluIFfJOVAhRSBzMD65OlQ5KM7:TT6= M4C2UlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOEWwNlA1Lz5{MEi1NFIxPDxxYU6=
SKOV3 NU\M[YM1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVO0PEBpenN? M3G4bmdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJHNMV1Z|IHPlcIx{KGGodHXyJFQ5KGi{czDifUB{fWyob4Loc4RidWmwZTDCJIF{e2G7LDDHTVUxKD1iMkGuPFc4PiEQvF2u MnvyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6NUCyNFQoRjJyOEWwNlA1RC:jPh?=
HCT116 Ml\JRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MU[3NkBpenN? Mn;rRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ2SxNVYh[2WubIOg[ZhxemW|c3nu[{BxPTNiYX\0[ZIhPzJiaILzJIJ6KGOnbHz0bZRmei2pbH:gZZN{[XluIFnDOVAhRSBzMjFOwG0v MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODh5M{e0NEc,OjB6N{O3OFA9N2F-
A2780 NHfZS3NCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NGLOTpE4OiCqcoO= NYLFTYI3SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBNlc5OCClZXzsd{BmgHC{ZYPzbY5oKHB3MzDh[pRmeiB5MjDodpMh[nliY3XscJRqfGW{LXfsc{Bie3OjeTygTWM2OCB;IEG0JO69VS5? NFHrdmU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEi3N|c1OCd-MkC4O|M4PDB:L3G+
U2OS M2XaRmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 Ml\EO|IhcHK| M37ue2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iVULPV{Bk\WyuczDlfJBz\XO|aX7nJJA2OyCjZoTldkA4OiCqcoOgZpkh[2WubITpeIVzNWeubzDhd5NigSxiSVO1NEA:KDF4IN88UU4> NGmxSWQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEi3N|c1OCd-MkC4O|M4PDB:L3G+
p53 deficient PC3 NH7sPWJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MVS3NkBpenN? MUPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKHB3MzDk[YZq[2mnboSgVGM{KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDj[YxtfGm2ZYKt[4xwKGG|c3H5MEBKSzVyIE2gN|Ah|ryPLh?= NXzWWVRmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4O|M4PDBpPkKwPFc{PzRyPD;hQi=>
SF539 M1i3SWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M{C0XlczKGi{cx?= MlnDRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCVRkWzPUBk\WyuczDlfJBz\XO|aX7nJJA2OyCjZoTldkA4OiCqcoOgZpkh[2WubITpeIVzNWeubzDhd5NigSxiSVO1NEA:KDR|IN88UU4> MmXBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6N{O3OFAoRjJyOEezO|QxRC:jPh?=
HCT15 Ml;sRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NXG1bIFpPzJiaILz NH;kZZZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFE2KGOnbHzzJIV5eHKnc4PpcocheDV|IHHmeIVzKDd{IHjyd{BjgSClZXzseIl1\XJvZ3zvJIF{e2G7LDDJR|UxKD1iNEig{txONg>? NEjTd5I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEi3N|c1OCd-MkC4O|M4PDB:L3G+
T3M4 NH3UPXZEgXSxdH;4bYNqfHliYYPzZZk> MYPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDUN201KGOnbHzzJIJ6KGO{eYP0ZYwhfmmxbHX0JJN1[WmwaX7nMEBKSzVyIE2gNE4{OyEQvF2u NVHVcpozRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC5N|AyOjNpPkKwPVMxOTJ|PD;hQi=>
Colo-357 NFnFZWZEgXSxdH;4bYNqfHliYYPzZZk> MXzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDc4xwNTN3NzDj[YxteyCkeTDjdpl{fGGuII\pc4xmfCC|dHHpcolv\yxiSVO1NEA:KDJwMEWg{txONg>? NIDwcVg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEmzNFEzOyd-MkC5N|AyOjN:L3G+
Patu-T MoTlR5l1d3SxeHnjbZR6KGG|c3H5 M4X2XGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBifHVvVDDj[YxteyCkeTDjdpl{fGGuII\pc4xmfCC|dHHpcolv\yxiSVO1NEA:KDJwMEig{txONg>? MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODl|MEGyN{c,OjB7M{CxNlM9N2F-
Patu-S Mkm0R5l1d3SxeHnjbZR6KGG|c3H5 NYryd2pIS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWGG2dT3TJINmdGy|IHL5JINzgXO2YXygeolwdGW2IIP0ZYlvcW6pLDDJR|UxKD1iMj65N{DPxE1w MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODl|MEGyN{c,OjB7M{CxNlM9N2F-
Aspc-1 MULDfZRwfG:6aXPpeJkh[XO|YYm= NGX1b5dEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCe3ClLUGgZ4VtdHNiYomgZ5J6e3SjbDD2bY9t\XRic4ThbY5qdmduIFnDOVAhRSB{Lkm3JO69VS5? MmDRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB7M{CxNlMoRjJyOUOwNVI{RC:jPh?=
PANC1 MV;DfZRwfG:6aXPpeJkh[XO|YYm= NEj6O2pEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSU6FMTDj[YxteyCkeTDjdpl{fGGuII\pc4xmfCC|dHHpcolv\yxiSVO1NEA:KDNwOUSg{txONg>? NGS4N5M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEmzNFEzOyd-MkC5N|AyOjN:L3G+
Patu-02 M1PRW2N6fG:2b4jpZ4l1gSCjc4PhfS=> MXrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQZZR2NTB{IHPlcIx{KGK7IHPyfZN1[WxidnnvcIV1KHO2YXnubY5oNCCLQ{WwJF0hOy57NTFOwG0v MnTLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB7M{CxNlMoRjJyOUOwNVI{RC:jPh?=
DAN-G Mk\PR5l1d3SxeHnjbZR6KGG|c3H5 MX\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDERW4uTyClZXzsd{BjgSClconzeIFtKH[rb3zleEB{fGGrbnnu[{whUUN3MDC9JFQvOzhizszNMi=> MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODl|MEGyN{c,OjB7M{CxNlM9N2F-
Patu-T M1XmW2N6fG:2b4jpZ4l1gSCjc4PhfS=> NV;2emlwS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hPS2IVT3y[ZNqe3SjboSgVIF1fS2WIHPlcIx{KGK7IHPyfZN1[WxidnnvcIV1KHO2YXnubY5oNCCLQ{WwJF0hOzNwMjFOwG0v M{DKWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOUOwNVI{Lz5{MEmzNFEzOzxxYU6=
Hep2 MUTBcpRq[2GwY3XyJIF{e2G7 NIP0ZVA1QCCqcoO= NFPL[XNCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gTIVxOiClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gNE4{KM7:TT6= MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB5NES0OEc,OjFyN{S0OFQ9N2F-
A549 M3PjT2FvfGmlYX7j[ZIh[XO|YYm= M323PFQ5KGi{cx?= M{DWOWFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTCyMlQh|ryPLh?= MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB5NES0OEc,OjFyN{S0OFQ9N2F-
HCT15 MnzWRY51cWOjbnPldkBie3OjeR?= MWK0PEBpenN? MnHWRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFE2KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTCzMlYh|ryPLh?= M{Lp[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMEe0OFQ1Lz5{MUC3OFQ1PDxxYU6=
502713 MlTRRY51cWOjbnPldkBie3OjeR?= NF3ydpY1QCCqcoO= MnLMRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIEWwNlcyOyClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gOE43KM7:TT6= NYfIPWF{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGwO|Q1PDRpPkKxNFc1PDR2PD;hQi=>
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DU145 NX7YSVNwS3m2b4TvfIlkcXS7IHHzd4F6 MkXJO|IhcHK| NYK1c|BoS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hTFVzNEWgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF{LkOyJO69VS5? NYDkWWtDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK2PFc4PDVpPkKyOlg4PzR3PD;hQi=>
SGC7901 MYnDfZRwfG:6aXPpeJkh[XO|YYm= NEH5[Xk4OiCqcoO= NYrjcXNCS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0eFN{mwNUBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUSuOFkh|ryPLh?= M37BUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{Nki3O|Q2Lz5{Mk[4O|c1PTxxYU6=
HeLa NVe4d2U3S3m2b4TvfIlkcXS7IHHzd4F6 NEDOVYI4OiCqcoO= M122eGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmVGFiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE2Njl7IN88UU4> MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjZ6N{e0OUc,OjJ4OEe3OFU9N2F-
HepG2 NHXr[3FEgXSxdH;4bYNqfHliYYPzZZk> MkflO|IhcHK| M2rYNGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA{Oi5{MjFOwG0v MlHNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ4OEe3OFUoRjJ{Nki3O|Q2RC:jPh?=
NCI-H460 NITwWZBEgXSxdH;4bYNqfHliYYPzZZk> MoL3O|IhcHK| NUfKcYsyS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVkOLLVi0OlAh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKuOEDPxE1w MlfiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ5Mke0OFUoRjJ{N{K3OFQ2RC:jPh?=
BGC823 M3HNPGN6fG:2b4jpZ4l1gSCjc4PhfS=> NIOweYw4OiCqcoO= MVjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDCS2M5OjNiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFQvPSEQvF2u MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjd{N{S0OUc,OjJ5Mke0OFU9N2F-
HepG2 NIm4fXdEgXSxdH;4bYNqfHliYYPzZZk> M2PDS|czKGi{cx?= NWPDWFBKS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDRwODFOwG0v MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjd{N{S0OUc,OjJ5Mke0OFU9N2F-
SGC7901 M4HUd2N6fG:2b4jpZ4l1gSCjc4PhfS=> MkfmO|IhcHK| NYD6NpNDS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0eFN{mwNUBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNj6zJO69VS5? NF;iepA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkeyO|Q1PSd-MkK3Nlc1PDV:L3G+
MCF7 NUnnPGhvS3m2b4TvfIlkcXS7IHHzd4F6 MXG3NkBpenN? NHjGcplEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyOi53IN88UU4> NXezeHBORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK3Nlc1PDVpPkKyO|I4PDR3PD;hQi=>
KB MVrDfZRwfG:6aXPpeJkh[XO|YYm= Mn[2O|IhcHK| MnPGR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT2Ih[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEiuNlgh|ryPLh?= NX3LcnVIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK3OFkyQTJpPkKyO|Q6OTl{PD;hQi=>
MCF7 M{frWmN6fG:2b4jpZ4l1gSCjc4PhfS=> NGC4PYI4OiCqcoO= M4PUUWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE1NjJizszNMi=> Mn\mQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ5NEmxPVIoRjJ{N{S5NVkzRC:jPh?=
CNE2 M4DUe2N6fG:2b4jpZ4l1gSCjc4PhfS=> NHzUT484OiCqcoO= NITiUGVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBEVkV{IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyPS5zIN88UU4> Mnq4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ5NEmxPVIoRjJ{N{S5NVkzRC:jPh?=
GLC82 M{ixXWN6fG:2b4jpZ4l1gSCjc4PhfS=> NFP2cI84OiCqcoO= Mmr4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gS2xEQDJiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE4NjRizszNMi=> M4fQUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{N{S5NVkzLz5{Mke0PVE6OjxxYU6=
MGC803 MnnOR5l1d3SxeHnjbZR6KGG|c3H5 NXHLXFdUPzJiaILz M3fUNmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ISzhyMzDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOThwNTFOwG0v MlvDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ5NEmxPVIoRjJ{N{S5NVkzRC:jPh?=
MCF7 MlfHRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MlTJO|IhcHK| NWDzem45SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDjdpl{fGGuII\pc4xmfCC|dHHpcolv\yCvZYToc4QtKEmFNUCgQUA1NjdizszNMi=> NHPJd2U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mke2OVg6Pyd-MkK3OlU5QTd:L3G+
HT-29 MYLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NX:zco5JPzJiaILz NUfNW|JQSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIWE0zQSClZXzsd{Bi\nSncjC3NkBpenNiYomgZ5J6e3SjbDD2bY9t\XRic4ThbY5qdmdibXX0bI9lNCCLQ{WwJF0hPy5|IN88UU4> NXn5UZA5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK3OlU5QTdpPkKyO|Y2QDl5PD;hQi=>
MDA-MB-231 M2nNO2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 MVy3NkBpenN? M3Xoe2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTJ|MTDj[YxteyCjZoTldkA4OiCqcoOgZpkh[3K7c4ThcEB3cW:uZYSgd5RicW6rbnegcYV1cG:mLDDJR|UxKD1iOT62JO69VS5? NW\JbJBLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK3OlU5QTdpPkKyO|Y2QDl5PD;hQi=>
HT1080 MU\DfZRwfG:6aXPpeJkh[XO|YYm= NI\HPYNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJXDFyOECgZ4VtdHNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN{4xPiEQvF2u M{O5fFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OECxOlQ1Lz5{MkiwNVY1PDxxYU6=
A375-S2 MX\DfZRwfG:6aXPpeJkh[XO|YYm= M4f1OGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE{PzVvU{KgZ4VtdHNiYomgUXRVKGG|c3H5MEBKSzVyIE2gPU46OiEQvF2u NHu0PVY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkiwNVY1PCd-MkK4NFE3PDR:L3G+
HeLa M2nwU2N6fG:2b4jpZ4l1gSCjc4PhfS=> M4[zOWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmVGFiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUCuN|Yh|ryPLh?= MmfBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6MEG2OFQoRjJ{OECxOlQ1RC:jPh?=
HepG2 MWXDfZRwfG:6aXPpeJkh[XO|YYm= NFy5cI1EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxNE41PSEQvF2u M3\aXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OECxOlQ1Lz5{MkiwNVY1PDxxYU6=
BGC823 NFjCZoJEgXSxdH;4bYNqfHliYYPzZZk> NYrPZXdNS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSkeFOEKzJINmdGy|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE2NjZ3IN88UU4> MkPGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6MEG2OFQoRjJ{OECxOlQ1RC:jPh?=
Hep2 NXHvfGc4S3m2b4TvfIlkcXS7IHHzd4F6 MWXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZAzKGOnbHzzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ2LkW4JO69VS5? NHPifYQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkiwNVY1PCd-MkK4NFE3PDR:L3G+
MCF7 NHTK[FVEgXSxdH;4bYNqfHliYYPzZZk> MULDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ2LkW4JO69VS5? NHr6VmQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkiwNVY1PCd-MkK4NFE3PDR:L3G+
A549 NF;UUVFEgXSxdH;4bYNqfHliYYPzZZk> NI\YbFREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OCB;IEOxMlUzKM7:TT6= NWDKS4FGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4NFE3PDRpPkKyPFAyPjR2PD;hQi=>
MDA231 MW\DfZRwfG:6aXPpeJkh[XO|YYm= MVHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEzOzFiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxKD1iM{GuOVch|ryPLh?= NIPGO209[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkiwNVY1PCd-MkK4NFE3PDR:L3G+
PC3 MknoR5l1d3SxeHnjbZR6KGG|c3H5 NFz6bXZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSzNiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxKD1iM{WuO|Uh|ryPLh?= MnnOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6MEG2OFQoRjJ{OECxOlQ1RC:jPh?=
PC3M M13pSWN6fG:2b4jpZ4l1gSCjc4PhfS=> MnK1OFghcHK| NVH3eWFsS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEN|TTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjJwNkOg{txONg>? NEPrT|Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkiwPVU2QCd-MkK4NFk2PTh:L3G+
A549 NYm4b2tGS3m2b4TvfIlkcXS7IHHzd4F6 MYG0PEBpenN? M4XDWmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFM2NjRzIN88UU4> MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjhyOUW1PEc,OjJ6MEm1OVg9N2F-
MKN45 NUO4fW5qS3m2b4TvfIlkcXS7IHHzd4F6 M3nIcFQ5KGi{cx?= NWXWTZVSS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUuQNEWgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDRzLkezJO69VS5? NXvUSGVwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4NFk2PThpPkKyPFA6PTV6PD;hQi=>
HepG2 NXvSXHRtS3m2b4TvfIlkcXS7IHHzd4F6 Mn\HOFghcHK| Ml\LR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFQ3Njh|IN88UU4> MorEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6MEm1OVgoRjJ{OEC5OVU5RC:jPh?=
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A549 NEjn[GdCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M1;iWVQ5KGi{cx?= M1L5SWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUKuPEDPxE1w MojuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6NEC0PVMoRjJ{OESwOFk{RC:jPh?=
MCF7 MlXlRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NWDQcItZPDhiaILz Mk\KRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzNj6yJO69VS5? M1vQfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OESwOFk{Lz5{Mki0NFQ6OzxxYU6=
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CAMA1 MmLkR5l1d3SxeHnjbZR6KGG|c3H5 M3rVZlczKGi{cx?= M2\3b2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNCVUFzIHPlcIx{KGmwY4XiZZRm\CCob4KgO|IhcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFEvOjhizszNMi=> NIi5RnQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mki2O|cxPyd-MkK4Olc4ODd:L3G+
MCF7 MnXnR5l1d3SxeHnjbZR6KGG|c3H5 NVrMO2FiPzJiaILz Mmr1R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{BqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTCzMlUh|ryPLh?= Mk\LQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6Nke3NFcoRjJ{OE[3O|A4RC:jPh?=
HepG2 MX7DfZRwfG:6aXPpeJkh[XO|YYm= NXftcHMyPzJiaILz NG\qfWhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBUWkJiYYPzZZktKEmFNUCgQUA2NjdizszNMi=> M2jhS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OE[3O|A4Lz5{Mki2O|cxPzxxYU6=
FOCUS NG[xeopEgXSxdH;4bYNqfHliYYPzZZk> MlLSO|IhcHK| M4XVUWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGZQS1WVIHPlcIx{KGmwY4XiZZRm\CCob4KgO|IhcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFcvPjlizszNMi=> NWq3NHJQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4Olc4ODdpPkKyPFY4PzB5PD;hQi=>
T47D NFvjfZBEgXSxdH;4bYNqfHliYYPzZZk> Mo\FO|IhcHK| M1[4W2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHQ1P0RiY3XscJMhcW6ldXLheIVlKG[xcjC3NkBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gPE46OSEQvF2u MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh4N{ewO{c,OjJ6Nke3NFc9N2F-
MV M33SR2N6fG:2b4jpZ4l1gSCjc4PhfS=> M1fJb|czKGi{cx?= NHTCNoNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOXiClZXzsd{BqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTC5Mlk4KM7:TT6= MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh4N{ewO{c,OjJ6Nke3NFc9N2F-
HCT116 MmnnR5l1d3SxeHnjbZR6KGG|c3H5 NWL3cY5sPzJiaILz NGPVZ3ZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJS1RzMU[gZ4VtdHNiaX7jeYJifGWmIH\vdkA4OiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwJF0hOThwNzFOwG0v MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh4N{ewO{c,OjJ6Nke3NFc9N2F-
MFE296 MkfIR5l1d3SxeHnjbZR6KGG|c3H5 NIHPPYY4OiCqcoO= NH7k[IREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTkV{OU[gZ4VtdHNiaX7jeYJifGWmIH\vdkA4OiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwJF0hOzBwNkig{txONg>? NVP5WoNYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4Olc4ODdpPkKyPFY4PzB5PD;hQi=>
HuH7 MXvDfZRwfG:6aXPpeJkh[XO|YYm= M3XZOlczKGi{cx?= NFfyfIpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJfUh5IHPlcIx{KGmwY4XiZZRm\CCob4KgO|IhcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFMxNjdizszNMi=> NVH4PItpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4Olc4ODdpPkKyPFY4PzB5PD;hQi=>
BT20 MXHDfZRwfG:6aXPpeJkh[XO|YYm= MlvDO|IhcHK| NFXxOGpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBDXDJyIHPlcIx{KGmwY4XiZZRm\CCob4KgO|IhcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFQ4NjNizszNMi=> MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh4N{ewO{c,OjJ6Nke3NFc9N2F-
COLO320 NV3zPYhCS3m2b4TvfIlkcXS7IHHzd4F6 M4rld|czKGi{cx?= M{jIcWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNQVE9|MkCgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KFeVVD2xJIF{e2G7LDDJR|UxKD1iMUKuOUDPxE1w M{LEcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OUW1NFk2Lz5{Mkm1OVA6PTxxYU6=
MCF7 NX:5e4RQS3m2b4TvfIlkcXS7IHHzd4F6 M4fURlczKGi{cx?= NHHqTG5EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFczKGi{czDifUBkenm|dHHsJJZqd2yndDDzeIFqdmmwZzygTWM2OCB;IESuO{DPxE1w NITS[Xo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mkm1PVIxPSd-MkK5OVkzODV:L3G+
HT-29 Mn\ER5l1d3SxeHnjbZR6KGG|c3H5 MmH3O|IhcHK| M2\uRWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhVNTJ7IHPlcIx{KGGodHXyJFczKGi{czDifUBkenm|dHHsJJZqd2yndDDzeIFqdmmwZzygTWM2OCB;IEeuN{DPxE1w M1XkbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OUW5NlA2Lz5{Mkm1PVIxPTxxYU6=
MDA-MB-231 MonPR5l1d3SxeHnjbZR6KGG|c3H5 M{nDUVczKGi{cx?= NHT1UndEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDjdpl{fGGuII\pc4xmfCC|dHHpcolv\yxiSVO1NEA:KDlwNjFOwG0v MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl3OUKwOUc,OjJ7NUmyNFU9N2F-
HL60 MYjDfZRwfG:6aXPpeJkh[XO|YYm= Mn65O|IhcHK| M2nHd2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhNPjBiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvODZizszNMi=> MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl3OUWxPEc,OjJ7NUm1NVg9N2F-
HeLa MlftR5l1d3SxeHnjbZR6KGG|c3H5 MXq3NkBpenN? NWDqTIFXS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5{ODFOwG0v NE\qOJQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mkm1PVUyQCd-MkK5OVk2OTh:L3G+
U937 M3S1XWN6fG:2b4jpZ4l1gSCjc4PhfS=> Mlf0O|IhcHK| M4Hk[2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHU6OzdiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFEvODdizszNMi=> NWr0fpJYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK5OVk2OThpPkKyPVU6PTF6PD;hQi=>
colon cancer M1jReGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MWq0PEBpenN? NUnTR5V3SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDjc4xwdiClYX7j[ZIh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IHPlcIwh[2:3boTpcoch[W6jbInzbZMtKEeLNUCgQUA5NjRizszNMi=> NUfVcFYyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK5PVU3OjFpPkKyPVk2PjJzPD;hQi=>
leukemia NYjXTo9WSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M1nQelQ5KGi{cx?= MYTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKGyndXvlcYliKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDj[YxtKGOxdX70bY5oKGGwYXz5d4l{NCCJSUWwJF0hOTVwMTFOwG0v NITjbWg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mkm5OVYzOSd-MkK5PVU3OjF:L3G+
prostate cancer M3rlOmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MoTCOFghcHK| NG\FXWJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIIDyc5N1[XSnIHPhcoNmeiClZXzsd{Bi\nSncjC0PEBpenNiYomgZ4VtdCClb4XueIlv\yCjbnHsfZNqeyxiR1m1NEA:KDJ{Lkeg{txONg>? NITDR|A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mkm5OVYzOSd-MkK5PVU3OjF:L3G+
renal cancer M1qw[2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 MV:0PEBpenN? Mn\5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiC{ZX7hcEBk[W6lZYKgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KGOnbHygZ492dnSrbnegZY5idHm|aYOsJGdKPTBiPTC0OU43KM7:TT6= NF7MUIw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mkm5OVYzOSd-MkK5PVU3OjF:L3G+
HeLa MW\DfZRwfG:6aXPpeJkh[XO|YYm= MmjQOFghcHK| M2TCbmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmVGFiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFkvPSEQvF2u MknaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyMEK5NlQoRjJ|MECyPVI1RC:jPh?=
MNK45 M{HlT2N6fG:2b4jpZ4l1gSCjc4PhfS=> MVG0PEBpenN? NUHRSlBwS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVU6NNEWgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF{IN88UU4> MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzByMkmyOEc,OjNyMEK5NlQ9N2F-
HepG2 M{PoS2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 M1K3R|Q5KGi{cx?= MXrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEincFeyJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgcYV1cG:mLDDJR|UxKD1iMT6zJO69VS5? MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzBzOEC5Okc,OjNyMUiwPVY9N2F-
BGC823 Mo\qRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MljhOFghcHK| MWPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEKJQ{iyN{Bk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJI1mfGixZDygTWM2OCB;IEGuOVIh|ryPLh?= MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzBzOEC5Okc,OjNyMUiwPVY9N2F-
SW1116 Mn\5RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MlTUOFghcHK| Mnj4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCVV{GxNVYh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBu\XSqb3SsJGlEPTBiPTCyMlQyKM7:TT6= MnjzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyMUiwPVYoRjJ|MEG4NFk3RC:jPh?=
HeLa NFLHVlFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MmHXOFghcHK| NVTadm06SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQhdWW2aH;kMEBKSzVyIE2gN{4zPSEQvF2u MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzBzOEC5Okc,OjNyMUiwPVY9N2F-
A549 NGexTlBEgXSxdH;4bYNqfHliYYPzZZk> M1fCOVQ5KGi{cx?= NUfDTlNPS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjc4Pld5Nm\CClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gOE4zOSEQvF2u MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB2NEO3NEc,OjNyNESzO|A9N2F-
HT1080 NHH3VHFEgXSxdH;4bYNqfHliYYPzZZk> NHfNeY01QCCqcoO= MmLTR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTHQyODhyIHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyPS5{IN88UU4> MkXFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyNke1OFkoRjJ|ME[3OVQ6RC:jPh?=
HCT116 NEDBUmJEgXSxdH;4bYNqfHliYYPzZZk> NHvpZ5E1QCCqcoO= MnzHR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGNVOTF4IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA{Pi52IN88UU4> MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB4N{W0PUc,OjNyNke1OFk9N2F-
2008 MnPtS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MV7Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjCyNFA5KGOnbHzzJIJ6KGO{eYP0ZYwhfmmxbHX0JIF{e2G7LDDJR|UxKD1iND6yJO69VS5? NIrDWpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{C3OVQyPCd-MkOwO|U1OTR:L3G+
Vero NG\ZdYdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3\1Z2dzd3e2aDDpcohq[mm2aX;uJI9nKGGocnnjZY4h\3KnZX6gcY9vc2W7IG\ldo8h[2WubIOgZpkh[3K7c4ThcEB3cW:uZYSgZZN{[XluIFnDOVAhRSB2LkWg{txONg>? NHnjepI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{C3OVQyPCd-MkOwO|U1OTR:L3G+
A2780 NF7sW49Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{Hqdmdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGEzPzhyIHPlcIx{KGK7IHPyfZN1[WxidnnvcIV1KGG|c3H5MEBKSzVyIE2gOU4yKM7:TT6= NYDQ[lFFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwO|U1OTRpPkKzNFc2PDF2PD;hQi=>
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HeLa Mn22RY51cXS3bX;yJIF{e2G7 Ml3QOFghcHK| M{fwXWFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjlUIEh[2WubIOgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44hdWWjc4Xy[YQh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE1Njd6IN88UU4> MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{[zOUc,OjN|MUO2N|U9N2F-
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MGC803 MXjDfZRwfG:6aXPpeJkh[XO|YYm= MWe3NkBpenN? NHHNbI9EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOT0N6MEOgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEeuNFEh|ryPLh?= NHXJSYM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{O1N|c1Oyd-MkOzOVM4PDN:L3G+
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leukemia NVK4R3k6S3m2b4TvfIlkcXS7IHHzd4F6 NXvEb|JRPDhiaILz MXjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDs[ZVs\W2rYTDj[YxteyCjZoTldkA1QCCqcoOgZpkhe3WucHjvdohw\GGvaX7lJGIh[XO|YYmsJGdKPTBiPTCxOU4yKM7:TT6= MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzR5NEi5PUc,OjN2N{S4PVk9N2F-
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HeLa NEjUSVhEgXSxdH;4bYNqfHliYYPzZZk> NHTNTFA1QCCqcoO= NW\1OnFHS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPy5|NDFOwG0v Mm\GQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3NUiyN|goRjJ|NUW4NlM5RC:jPh?=
HL60 NVfGN4FDS3m2b4TvfIlkcXS7IHHzd4F6 M4\jbVQ5KGi{cx?= MVzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIUFYxKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxNE4xPSEQvF2u MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzV3OEKzPEc,OjN3NUiyN|g9N2F-
MCF7 NXrxRYlVS3m2b4TvfIlkcXS7IHHzd4F6 M1PISlQ5KGi{cx?= M3Hl[WN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFEyNjVizszNMi=> MlLMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3NUiyN|goRjJ|NUW4NlM5RC:jPh?=
K562 Mo\vR5l1d3SxeHnjbZR6KGG|c3H5 NXfabZFVPDhiaILz NVPB[4duS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjNwNUWg{txONg>? MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzV3OEKzPEc,OjN3NUiyN|g9N2F-
U937 NV3KVVFIS3m2b4TvfIlkcXS7IHHzd4F6 Mn21OFghcHK| NFTjXndEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBWQTN5IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzOy57MzFOwG0v NIXIUJA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{W1PFI{QCd-MkO1OVgzOzh:L3G+
HCT116 MlLDR5l1d3SxeHnjbZR6KGG|c3H5 NXjMVVV7PDhiaILz M3XGfWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhEXDFzNjDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjdwN{[g{txONg>? NGWyOW49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{W1PFI{QCd-MkO1OVgzOzh:L3G+
HT1080 NITtXWZEgXSxdH;4bYNqfHliYYPzZZk> MWe0PEBpenN? MljhR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTHQyODhyIHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA{PS54MjFOwG0v NEPCVYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{W1PFI{QCd-MkO1OVgzOzh:L3G+
HepG2 NGf1NYFEgXSxdH;4bYNqfHliYYPzZZk> MV20PEBpenN? M1ThZmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA1OC5|NDFOwG0v MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzV3OEKzPEc,OjN3NUiyN|g9N2F-
A549 MlLER5l1d3SxeHnjbZR6KGG|c3H5 NHHrXXE1QCCqcoO= NIXYTHJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA1PC5yNTFOwG0v NXHBTYoxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1OVgzOzhpPkKzOVU5OjN6PD;hQi=>
EC9706 MX;DfZRwfG:6aXPpeJkh[XO|YYm= NXTkfZVNPzJiaILz M4fEOGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGVEQTdyNjDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5|MjFOwG0v MlzMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4NESxPVMoRjJ|NkS0NVk{RC:jPh?=
MGC803 M3rUXWN6fG:2b4jpZ4l1gSCjc4PhfS=> MX63NkBpenN? MkC3R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWdEQDB|IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA4NjF2IN88UU4> MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ2NEG5N{c,OjN4NESxPVM9N2F-
MCF7 MlyzR5l1d3SxeHnjbZR6KGG|c3H5 MkjDO|IhcHK| Ml\sR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gO{4{OyEQvF2u MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ2NEG5N{c,OjN4NESxPVM9N2F-
SMMC7721 Mne2R5l1d3SxeHnjbZR6KGG|c3H5 MX:3NkBpenN? NUn1UHhzS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW02PQ{e3NlEh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEK2MlcyKM7:TT6= NHHBVlE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[0OFE6Oyd-MkO2OFQyQTN:L3G+
HCT116 MYDDfZRwfG:6aXPpeJkh[XO|YYm= NXW5UpVQPDhiaILz M1f1ZWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhEXDFzNjDj[YxteyCjZoTldkA1QCCqcoOgZpkhe3WuZn;ybI9l[W2rbnWgRkBie3OjeTygTWM2OCB;IESuOVIh|ryPLh?= NYT0bYw{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2OFQzOTVpPkKzOlQ1OjF3PD;hQi=>
HT-29 MYTDfZRwfG:6aXPpeJkh[XO|YYm= MonXOFghcHK| MU\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIWE0zQSClZXzsd{Bi\nSncjC0PEBpenNiYomgd5Vt\m:{aH;kZY1qdmViQjDhd5NigSxiSVO1NEA:KDZwM{Wg{txONg>? NUnhNItqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2OFQzOTVpPkKzOlQ1OjF3PD;hQi=>
A549 M{LwVWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NGXpR5k4OiCqcoO= NUfPVWU6SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzMlUzKM7:TT6= NIXhUW49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[2OVExPid-MkO2OlUyODZ:L3G+
HCT116 MlLURY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NWr3[GZsPzJiaILz MkfKRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ2SxNVYh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEWuOVMh|ryPLh?= M3;nWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|Nk[1NVA3Lz5{M{[2OVExPjxxYU6=
HT-29 NIX5XmdCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NFPTfnI4OiCqcoO= M1S1UGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSGStNlkh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEK0MlUh|ryPLh?= MnH1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4NkWxNFYoRjJ|Nk[1NVA3RC:jPh?=
MCF7 M2fQd2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 NXu3fI5YPzJiaILz M37abGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iM{KuNVgh|ryPLh?= Mn;IQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4NkWxNFYoRjJ|Nk[1NVA3RC:jPh?=
HeLa NVzwTm4{SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MoC3O|IhcHK| NWrBelgzSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC0N{44OSEQvF2u M3zQUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|Nk[1NVA3Lz5{M{[2OVExPjxxYU6=
colon cancer M1P1XmN6fG:2b4jpZ4l1gSCjc4PhfS=> NVyxdXhWPDhiaILz MYTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDjc4xwdiClYX7j[ZIh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IHPveYx1\XJiY3;1cpRmeiCjbnHsfZNqeyxiR1m1NEA:KDhwNDFOwG0v NWXWO5BWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2PFM2QTJpPkKzOlg{PTl{PD;hQi=>
leukemia MVPDfZRwfG:6aXPpeJkh[XO|YYm= Mn3OOFghcHK| NXz5PZVZS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hdGW3a3XtbYEh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IHPveYx1\XJiY3;1cpRmeiCjbnHsfZNqeyxiR1m1NEA:KDF3LkGg{txONg>? MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ6M{W5Nkc,OjN4OEO1PVI9N2F-
prostate cancer M3TRemN6fG:2b4jpZ4l1gSCjc4PhfS=> MVy0PEBpenN? NV2xbWJKS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4heHKxc4TheIUh[2GwY3XyJINmdGy|IHHmeIVzKDR6IHjyd{BjgSClb4XseIVzKGOxdX70[ZIh[W6jbInzbZMtKEeLNUCgQUAzOi55IN88UU4> NI\4V4E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[4N|U6Oid-MkO2PFM2QTJ:L3G+
renal cancer M17sfGN6fG:2b4jpZ4l1gSCjc4PhfS=> Ml35OFghcHK| M2q3b2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJJJmdmGuIHPhcoNmeiClZXzsd{Bi\nSncjC0PEBpenNiYomgZ492dHSncjDjc5VvfGW{IHHuZYx6e2m|LDDHTVUxKD1iNEWuOkDPxE1w NVzMUFZPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2PFM2QTJpPkKzOlg{PTl{PD;hQi=>
SH-SY5Y NICw[|JEgXSxdH;4bYNqfHliYYPzZZk> M2rqfVczKGi{cx?= NWHnWVZwS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0hvU2m1XUBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMD65O{DPxE1w MkTHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4OEW1O|EoRjJ|Nki1OVcyRC:jPh?=
HCT116 MlqwR5l1d3SxeHnjbZR6KGG|c3H5 NFu2dlA4OiCqcoO= MnPGR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGNVOTF4IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA{NjJ2IN88UU4> MnvZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4OEW1O|EoRjJ|Nki1OVcyRC:jPh?=
A549 NXLNXXpSS3m2b4TvfIlkcXS7IHHzd4F6 MkTBO|IhcHK| MmnMR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gPE44OSEQvF2u MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ6NUW3NUc,OjN4OEW1O|E9N2F-
Vero M4[2WmN6fG:2b4jpZ4l1gSCjc4PhfS=> MXm3NkBpenN? MVnDfZRwfG:6aXPpeJkh[WejaX7zeEBC\nKrY3HuJIdz\WWwIH3vcotmgSCYZYLvJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB7LkexJO69VS5? NXLYWpJDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2PFU2PzFpPkKzOlg2PTdzPD;hQi=>
MCF7 MX\DfZRwfG:6aXPpeJkh[XO|YYm= NEfFVWc4OiCqcoO= MW\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxNE4yPCEQvF2u MoP5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4OEW1O|EoRjJ|Nki1OVcyRC:jPh?=
HepG2 MWHDfZRwfG:6aXPpeJkh[XO|YYm= NFzzeY04OiCqcoO= NUG4PYVZS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ2Lkm2JO69VS5? MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ6NUW3NUc,OjN4OEW1O|E9N2F-
PC3 NYPCdHVqSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MYm3NkBpenN? NUD5UnpVSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOg[ZhxemW|c3nu[{BUU1B{IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{Nz6wO{DPxE1w M{DBclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|N{O1NlgyLz5{M{ezOVI5OTxxYU6=