Entinostat (MS-275)

For research use only. Not for use in humans.

目录号：S1053 别名： SNDX-275 中文名称：恩替诺特

CAS No. 209783-80-2

Entinostat (MS-275, SNDX-275)强烈抑制HDAC1和HDAC3，无细胞试验中IC50分别为0.51 μM和1.7 μM，抑制作用强于HDACs 4， 6， 8，和10。Entinostat可诱导自噬和凋亡。Phase 3。

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购买数量

10mM (1mL in DMSO)	RMB 746.45	现货
10mg	RMB 794.43	现货
25mg	RMB 1233.32	现货
50mg	RMB 2234.07	现货
200mg	RMB 6301.79	现货
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客户使用Selleck生产的Entinostat (MS-275)发表文献324篇：

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产品安全说明书

HDAC抑制剂选择性比较

生物活性

产品描述

靶点

HDAC1 ^[2] (Cell-free assay)	HDAC3 ^[2] (Cell-free assay)
0.51 μM	1.7 μM

体外研究

MS-275通过作用于2′-氨基而抑制HDACs。MS-275作用于 K562细胞，诱导 p21^WAF1/CIP1和凝溶胶蛋白的累积。MS-275作用于A2780细胞，可以降低S期细胞，提高G1期细胞。 MS-275通过抑制HAD而抑制人类肿瘤细胞系，包括 A2780, Calu-3, HL-60, K562, St-4, HT-29, KB-3-1, Capan-1, 4-1St和 HCT-15细胞增殖， IC50 为41.5 nM到4.71 μM。^[1]MS-275抑制HDACs，作用于HDAC1和 HDAC3时IC50 分别为0.51 μM和1.7 μM。而对其他的HDACs没有抑制效果，如HDAC4, 6, 8和10。^[2]MS-275有效抑制人类白血病和淋巴癌细胞，包括U937, HL-60, K562, 和Jurkat。MS-275可以诱导U937细胞p21CIP1/WAF1 调节的生长和变异Marker (CD11b)的表达。MS-275降低cyclin D1和抗凋亡蛋白Mcl-1与XIAP的表达。^[3]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
SCC-3	NVnDSXU4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NVPGe21vUUN3ME2wMlA3OSEQvF2=	NELaXIk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPzd3OT:nQnNCVkeHUkyvZV4>
ALL-PO	NGjSNoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M{PDe2lEPTB;MD6wOlM2PSEQvF2=	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyO\|c2QS9pPmPBUmdGWjxxYU6=
697	M1PIWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NIrucY5KSzVyPUCuNFk6PzZizszN	Ml;vQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlc4PTlxJ{7TRW5ITVJ:L3G+
NCI-H748	M4fDRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NETjS5BKSzVyPUCuNVA{OzRizszN	NWnXe2RvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjd5NUmvK\|5USU6JRWK8M4E,
NKM-1	NGjBbnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NGO3[pJKSzVyPUCuNVA6OTJizszN	MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyO\|c2QS9pPmPBUmdGWjxxYU6=
ES1	Ml34S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			Mnn0TWM2OD1yLkGxNlU2KM7:TR?=	MkDnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlc4PTlxJ{7TRW5ITVJ:L3G+
NCI-H1963	M3nGN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NWT6RpZxUUN3ME2wMlEyPTd7IN88US=>	NETGVJM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPzd3OT:nQnNCVkeHUkyvZV4>
NCI-H1417	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			M1rhcWlEPTB;MD6xNlk4PCEQvF2=	M12zZ\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI4PzV7Lze+V2FPT0WUPD;hQi=>
NEC8	MnvWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NF62T\|hKSzVyPUCuNVM2OjdizszN	MmXBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlc4PTlxJ{7TRW5ITVJ:L3G+
CRO-AP2	NULtdYFzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MmnGTWM2OD1yLkG2PFg6KM7:TR?=	MorrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlc4PTlxJ{7TRW5ITVJ:L3G+
A3-KAW	MormS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			M3m5W2lEPTB;MD6xO\|YzPyEQvF2=	MlTYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlc4PTlxJ{7TRW5ITVJ:L3G+
SF539	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NXXzRWpRUUN3ME2wMlE6PTl\|IN88US=>	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyO\|c2QS9pPmPBUmdGWjxxYU6=
NOS-1	M1TXfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MXPJR\|UxRTBwMUm2NVkh\|ryP	NHvRfno9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPzd3OT:nQnNCVkeHUkyvZV4>
NTERA-S-cl-D1	M2PhPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M4jW[mlEPTB;MD6yNFEyOyEQvF2=	NELFbXk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPzd3OT:nQnNCVkeHUkyvZV4>
COR-L88	M2j4bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NIe2V5FKSzVyPUCuNlI6PTlizszN	NUKyNGt1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjd5NUmvK\|5USU6JRWK8M4E,
EM-2	M{D6Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NH7meZFKSzVyPUCuNlQxPzlizszN	M4HSPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI4PzV7Lze+V2FPT0WUPD;hQi=>
KARPAS-45	Mnz4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NUW0PYcyUUN3ME2wMlI4QDN\|IN88US=>	M37OTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI4PzV7Lze+V2FPT0WUPD;hQi=>
DSH1	NXvxS4FCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MnLtTWM2OD1yLkK4O\|A5KM7:TR?=	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyO\|c2QS9pPmPBUmdGWjxxYU6=
HT-144	NFzE[21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M3jGPGlEPTB;MD6zNFI2PiEQvF2=	NGH4Upc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPzd3OT:nQnNCVkeHUkyvZV4>
ATN-1	Mmf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			M3vxfmlEPTB;MD6zNFU4PiEQvF2=	NVnFS5B4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjd5NUmvK\|5USU6JRWK8M4E,
HEL	NX;DRodPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NUnOe2N5UUN3ME2wMlMyOzR6IN88US=>	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyO\|c2QS9pPmPBUmdGWjxxYU6=
NB12	NYD1OWhFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NICybldKSzVyPUCuN\|E4PTZizszN	NUSxdHkyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjd5NUmvK\|5USU6JRWK8M4E,
LU-139	NYr1O\|FmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MlTFTWM2OD1yLkOzOVEh\|ryP	M4Xl[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI4PzV7Lze+V2FPT0WUPD;hQi=>
J-RT3-T3-5	MonGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NUjZe\|FHUUN3ME2wMlM{PzF4IN88US=>	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyO\|c2QS9pPmPBUmdGWjxxYU6=
MOLT-13	Mk[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			M17semlEPTB;MD6zN\|gyKM7:TR?=	MkLRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlc4PTlxJ{7TRW5ITVJ:L3G+
SR	M4rHfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NHfB[VhKSzVyPUCuN\|QzPjFizszN	MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyO\|c2QS9pPmPBUmdGWjxxYU6=
CMK	NUHrfZRWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MkDOTWM2OD1yLkO1O\|I4KM7:TR?=	NUC4cGlORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjd5NUmvK\|5USU6JRWK8M4E,
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OVCAR-4	M2\PSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MmLKTWM2OD1zLkGzNVY2KM7:TR?=	MlnEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlc4PTlxJ{7TRW5ITVJ:L3G+
A4-Fuk	NX7lOYd4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NV33fpY{UUN3ME2xMlE2OzZ2IN88US=>	MnOyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlc4PTlxJ{7TRW5ITVJ:L3G+
HCC2218	MkXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			M3HKOmlEPTB;MT6xOlY1OSEQvF2=	MomxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlc4PTlxJ{7TRW5ITVJ:L3G+
HAL-01	MoHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NUm4XItUUUN3ME2xMlE3QTR\|IN88US=>	M{fjNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI4PzV7Lze+V2FPT0WUPD;hQi=>
IST-MEL1	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			Mn;RTWM2OD1zLkG3OlU6KM7:TR?=	NIXWcnI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPzd3OT:nQnNCVkeHUkyvZV4>
NCI-H719	M2LMbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NH\PdYVKSzVyPUGuNVc5QThizszN	MlfuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlc4PTlxJ{7TRW5ITVJ:L3G+
EVSA-T	NELQfoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MkDyTWM2OD1zLkG4NVE1KM7:TR?=	MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyO\|c2QS9pPmPBUmdGWjxxYU6=
SK-NEP-1	NY\WdZp4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NFrYfZVKSzVyPUGuNlAzPjZizszN	MlHqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlc4PTlxJ{7TRW5ITVJ:L3G+
OCUB-M	NHrpcodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NGrmbopKSzVyPUGuNlE1QDlizszN	NIXTSW49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPzd3OT:nQnNCVkeHUkyvZV4>
MEG-01	NHnsZ2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MWjJR\|UxRTFwMkKxNVgh\|ryP	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyO\|c2QS9pPmPBUmdGWjxxYU6=
no-10	Mn33S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NI\RWodKSzVyPUGuNlMyOTJizszN	M2\icVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI4PzV7Lze+V2FPT0WUPD;hQi=>
MHH-CALL-2	NVjEdZF5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M1fxOmlEPTB;MT6yOFczOSEQvF2=	M{PV[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI4PzV7Lze+V2FPT0WUPD;hQi=>
SK-N-DZ	NUDO[mVRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NXzxSoRDUUN3ME2xMlI1Pzd4IN88US=>	NET5RlQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPzd3OT:nQnNCVkeHUkyvZV4>
SCLC-21H	NGDpbnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NFTZfpJKSzVyPUGuNlY1PzhizszN	Mn3GQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlc4PTlxJ{7TRW5ITVJ:L3G+
CTV-1	NFvtXpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M4rhWWlEPTB;MT6yO\|QzPSEQvF2=	NVW4SG1KRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjd5NUmvK\|5USU6JRWK8M4E,
NB1	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			Mli2TWM2OD1zLkK3O\|MzKM7:TR?=	NFz4OGI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPzd3OT:nQnNCVkeHUkyvZV4>
NCI-H64	NXixbYhRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NWLBZVR6UUN3ME2xMlI5PDZ{IN88US=>	NH3sN3Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPzd3OT:nQnNCVkeHUkyvZV4>
MDA-MB-134-VI	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MoPnTWM2OD1zLkK4OVc4KM7:TR?=	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyO\|c2QS9pPmPBUmdGWjxxYU6=
LB2241-RCC	M1fidmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NHXUTnNKSzVyPUGuNlg3PjNizszN	NUfhRow{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjd5NUmvK\|5USU6JRWK8M4E,
8-MG-BA	NEL6O4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M{nI[WlEPTB;MT6yPFg3PiEQvF2=	NFj6bGs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPzd3OT:nQnNCVkeHUkyvZV4>
LP-1	M4P1cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MWPJR\|UxRTFwMkm5OFch\|ryP	M1X5UFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI4PzV7Lze+V2FPT0WUPD;hQi=>
LS-411N	Mn7RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			M2HBd2lEPTB;MT6zNFk6QCEQvF2=	NFrVOZQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPzd3OT:nQnNCVkeHUkyvZV4>
CAL-148	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			M4WzZmlEPTB;MT6zNlU1OiEQvF2=	M4\WXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI4PzV7Lze+V2FPT0WUPD;hQi=>
NCI-H2171	NGLod3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MWDJR\|UxRTFwM{S1NFIh\|ryP	M1LaWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI4PzV7Lze+V2FPT0WUPD;hQi=>
JiyoyeP-2003	NYjQU\|BMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NUDsbG8yUUN3ME2xMlM2OzlizszN	NGrtcpQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPzd3OT:nQnNCVkeHUkyvZV4>
NCI-H2107	NX\tNZBvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M3XJT2lEPTB;MT6zOVg5OyEQvF2=	MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyO\|c2QS9pPmPBUmdGWjxxYU6=
BB30-HNC	NEXIUFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M{nscmlEPTB;MT6zPFk4QCEQvF2=	NGjxV2g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPzd3OT:nQnNCVkeHUkyvZV4>
K-562	M{H3WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MmezTWM2OD1zLkO5NlE6KM7:TR?=	NWn5[phjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjd5NUmvK\|5USU6JRWK8M4E,
PSN1	Mn7qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MlfyTWM2OD1zLkSyNlg4KM7:TR?=	M1W5SlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI4PzV7Lze+V2FPT0WUPD;hQi=>
HCC2157	M{PzSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M3;a[2lEPTB;MT60NlY6OSEQvF2=	MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyO\|c2QS9pPmPBUmdGWjxxYU6=
SBC-1	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NInnU3BKSzVyPUGuOFI4PDFizszN	M33kc\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI4PzV7Lze+V2FPT0WUPD;hQi=>
MC116	MlK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NVfJXI1FUUN3ME2xMlQ{PjF3IN88US=>	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyO\|c2QS9pPmPBUmdGWjxxYU6=
KARPAS-422	NX3kV5BUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M3H6T2lEPTB;MT60OVM2QCEQvF2=	NY\VR3duRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjd5NUmvK\|5USU6JRWK8M4E,
LB996-RCC	NH;1foNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MU\JR\|UxRTFwNEexNFMh\|ryP	MnXpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlc4PTlxJ{7TRW5ITVJ:L3G+
MSTO-211H	NEHOToZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NXvncm9SUUN3ME2xMlQ4QTh5IN88US=>	NGL6Z3Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPzd3OT:nQnNCVkeHUkyvZV4>
BT-474	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NGXBe2FKSzVyPUGuOVE4PjRizszN	M3vNS\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI4PzV7Lze+V2FPT0WUPD;hQi=>
A388	NXWzeHpuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NW\n[5BOUUN3ME2xMlUyQTR3IN88US=>	M1jlbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI4PzV7Lze+V2FPT0WUPD;hQi=>
SJSA-1	NF;QRmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NWH0UWV[UUN3ME2xMlUzOjZizszN	NFTi[XI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPzd3OT:nQnNCVkeHUkyvZV4>
COLO-829	M4rGcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M4XQVGlEPTB;MT61N\|U3PCEQvF2=	NHvX[2s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPzd3OT:nQnNCVkeHUkyvZV4>
KM-H2	NVPIfnRxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M{j0RmlEPTB;MT61OlY4KM7:TR?=	NHv6dXk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPzd3OT:nQnNCVkeHUkyvZV4>
GR-ST	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			M{jHPGlEPTB;MT61OlgzKM7:TR?=	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyO\|c2QS9pPmPBUmdGWjxxYU6=
RPMI-8866	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MVPJR\|UxRTFwNkCxOFQh\|ryP	MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyO\|c2QS9pPmPBUmdGWjxxYU6=
KG-1	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			Mn7LTWM2OD1zLk[xPVAyKM7:TR?=	M4nyN\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI4PzV7Lze+V2FPT0WUPD;hQi=>
NCI-H82	NV\SRnY1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NV3qOGlYUUN3ME2xMlY{PDB4IN88US=>	NUP0RlFrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjd5NUmvK\|5USU6JRWK8M4E,
LB1047-RCC	NUnPW4JrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NXTmcY1{UUN3ME2xMlY{PDV7IN88US=>	Mm\CQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlc4PTlxJ{7TRW5ITVJ:L3G+
KM12	NFq2OZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M3\0WGlEPTB;MT62OFch\|ryP	Mo\MQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlc4PTlxJ{7TRW5ITVJ:L3G+
NB5	NI\vdHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MoD2TWM2OD1zLk[1Olc4KM7:TR?=	MkSwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlc4PTlxJ{7TRW5ITVJ:L3G+
HDLM-2	MoLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NWPrUWV2UUN3ME2xMlY5OjhzIN88US=>	NI\rfms9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPzd3OT:nQnNCVkeHUkyvZV4>
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HEK293	MW\GeY5kfGmxbjDhd5NigQ>?			NXvpZmVsUW6qaXLpeIlwdiCxZjDoeY1idiCFLYTldo1qdmGuIF\MRWcufGGpZ3XkJGhFSUNzIHnuJGhGUzJ7MzDj[YxteyxiSVO1NEA:KDBwMUKg{txONg>?	MmDqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl2NEG4OFYoRjF7NESxPFQ3RC:jPh?=
HEK293	NEO5cXZHfW6ldHnvckBie3OjeR?=			M2n3V2lvcGmkaYTpc44hd2ZiSFTBR\|EhcW5iSFXLNlk{KGOnbHzzMEBKSzVyIE2gNE4yOiEQvF2u	MlXhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh\|MEi1OlMoRjF6M{C4OVY{RC:jPh?=
SNU16	NGrQ[ZBHfW6ldHnvckBie3OjeR?=			NUXFeIFmUW6qaXLpeIlwdiCxZjDISGFEKG[{b32gbJVu[W5iU17VNVYh[2WubIOsJGlEPTBiPTCwMlI{OyEQvF2u	MnPVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh{NEe1OVQoRjF6MkS3OVU1RC:jPh?=
HEK293	M1rYb2Z2dmO2aX;uJIF{e2G7			M37aV2lvcGmkaYTpc44hd2ZiaIXtZY4hSy22ZYLtbY5idCCITFHHMZRi\2enZDDISGFEOiCrbjDISWszQTNiY3XscJMtKEmFNUCgQUAxNjJ3IN88UU4>	MkOyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl2NEG4OFYoRjF7NESxPFQ3RC:jPh?=
U937	M4\qfWZ2dmO2aX;uJIF{e2G7			M{nSVmlvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{GgbY4hXTl\|NzDj[YxteyCkeTDpcY12dm:ycnXjbZBqfGG2aX;uJIF{e2G7LDDJR\|UxKD1iMD6zJO69VS5?	NG\B[XU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEO4NVI{QCd-MUizPFEzOzh:L3G+
SK-N-BE(2)	NFLmbYFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MUC0PEBpenN?	MmfvRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCVSz3OMWJGMDJrIHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjN\|IN88UU4>	MnH5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3MUG5NFYoRjJ6NUGxPVA3RC:jPh?=
AGS	NUXDeVRqSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MXm3NkBpenN?	MUXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEGJUzDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5\|NDFOwG0v	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTd6N{K2Nkc,Ojl5OEeyOlI9N2F-
MCF7	NUHEclY5SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		M4myc\|Q5KGi{cx?=	M3jX[GFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczD0doVifGWmIH\vdkA1QCCqcoOg[o9tdG:5ZXSgZpkhemWocnXzbIVlKGW4ZYL5JFk3KGi{czDt[YF{fXKnZDDvckBl[XliMUCgZpkhVG:5comgZZN{[XluIFnDOVAhRSByLkO1JO69VS5?	NX;nOXJ2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[2NVM3OzVpPkK2OlE{PjN3PD;hQi=>
HEK293	MV3GeY5kfGmxbjDhd5NigQ>?			M3;ue2lvcGmkaYTpc44hd2ZiaIXtZY4hSy22ZYLtbY5idCCITFHHMZRi\2enZDDISGFEOyCrbjDISWszQTNiY3XscJMtKEmFNUCgQUAxNjRizszNMi=>	M{jTN\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NESxPFQ3Lz5zOUS0NVg1PjxxYU6=
HEK293	NYK0WYc5TnWwY4Tpc44h[XO\|YYm=			MVnJcohq[mm2aX;uJI9nKEiGQVOzJIlvKEiHS{K5N{Bk\WyuczygTWM2OCB;IECuOEDPxE1w	NUL2VJFTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUizNFg2PjNpPkG4N\|A5PTZ\|PD;hQi=>
HEL	MknvSpVv[3Srb36gZZN{[Xl?		NFzSNXc{KGi{cx?=	NFnqNmpKdmirYnn0bY9vKG:oIHPsZZN{KDFiSFTBR{BqdiCKRVygZ4VtdHNidYPpcochSm:lLVz5d{Ap[WOndInsLU1CVUNiYYOgd5Vje3S{YYTlJJBz\WmwY4XiZZRm\CCob4KgN{BpenNiZn;scI94\WRiYomgd5Vje3S{YYTlJIFl\Gm2aX;uJI1m[XO3cnXkJIFnfGW{IEOgbJJ{KGK7IH\seY9z\XOlZX7j[UBie3OjeTygTWM2OCB;IECuOFMh\|ryPLh?=	Ml;iQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3MUG5NFYoRjJ6NUGxPVA3RC:jPh?=
PC3	MnvoS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		M{P5dlQ5KGi{cx?=	MoexS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gVGM{KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHHzd4F6NCCJSUWwJF0hOC52MzFOwG0v	NX7xfmtJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkizPVUyPTBpPkK4N\|k2OTVyPD;hQi=>
HEL	NXLK[5ZxSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MoLIO\|IhcHK\|	NVTvV\|NjSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDISWwh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuOFQh\|ryPLh?=	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTd6N{K2Nkc,Ojl5OEeyOlI9N2F-
MOLT4	M{DHRWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MlnxO\|IhcHK\|	MXjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2RTGS0JINmdGy\|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkS1JO69VS5?	MnqwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl5OEeyOlIoRjJ7N{i3NlYzRC:jPh?=
HCT116	MoixRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		Mn7YO\|IhcHK\|	NH\1PJRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFEyPiClZXzsd{Bi\nSncjC3NkBpenNiYomgR2NMNThiYYPzZZktKEmFNUCgQUAxNjR5IN88UU4>	NETRVY89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUKwNlM6Pyd-MkmyNFI{QTd:L3G+
HEL	NVP2OIRJSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		M{TjXVQ5KGi{cx?=	MX;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IFjFUEBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iMD60PEDPxE1w	NUe3bFB{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki1NVE6ODZpPkK4OVEyQTB4PD;hQi=>
HCT116	NYTmO5E{TnWwY4Tpc44h[XO\|YYm=			M2Xib2lvcGmkaYTpc44hd2ZiaIXtZY4hUEOWMUG2JINmdGy\|LDDJR\|UxKD1iMD61JO69VS5?	NVrjbYtyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUiyOFc2PTRpPkG4NlQ4PTV2PD;hQi=>
U937	MYnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NV75VJR[PzJiaILz	NYDEXms2SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDVPVM4KGOnbHzzJIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuOVUh\|ryPLh?=	NHXocHE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUm1N\|czOid-MkW5OVM4OjJ:L3G+
U937	MYnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NF7aZ2I4OiCqcoO=	MoXlRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCXOUO3JINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEBoem:5dHigZYZ1\XJiN{KgbJJ{KGK7IF3UWE1j[XOnZDDhd5NigSxiSVO1NEA:KDBwNUWg{txONg>?	M2rCU\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEe0N\|I3Lz5{NUi3OFMzPjxxYU6=
HCT116	MoDKS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		Mn74NkBl[Xm\|	MmCwS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gTGNVOTF4IHPlcIx{KGGodHXyJFIh\GG7czDifUBOXFRiYYPzZZktKEeLNUCgQUAxNjZizszNMi=>	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV2MUO5OEc,OjJ3NEGzPVQ9N2F-
HL60	NEfHdIdHfW6ldHnvckBie3OjeR?=		Mn3JN{BpenN?	M1\VXGlvcGmkaYTpc44hd2ZiY3zhd5MhOSCKRFHDJIlvKGi3bXHuJGhNPjBiY3XscJMhfXOrbnegRo9kNUGlLVz5d{1CVUNiYYOgd5Vje3S{YYTlJIlv[3WkYYTl[EBnd3JiMzDodpMh\m:ubH;3[YQh[nlic4Xid5Rz[XSnIHHk[Il1cW:wIH3lZZN2emWmIHHmeIVzKDNiaILzJIJ6KG[udX;y[ZNk\W6lZTDhd5NigSxiSVO1NEA:KDBwNkKg{txONg>?	MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDRzNUCwPUc,Ojh2MUWwNFk9N2F-
MOLT4	MmG5RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MljNOFghcHK\|	NXztUYVSSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNU2xVPCClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG\|c3H5MEBKSzVyIE2gNE43PSEQvF2u	NX;wZ\|VwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki1NVE6ODZpPkK4OVEyQTB4PD;hQi=>
HCT116	MXfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?			NWrFN\|dwSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMtKEmFNUCgQUAxNjZ5IN88UU4>	NYDZcHV2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG3OFI1QTZpPkKxO\|QzPDl4PD;hQi=>
HCT116	NEfESmFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=			MXrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEGxOkBk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckwhUUN3MDC9JFAvPjdizszNMi=>	NWexXGU{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG2OVAzOjFpPkKxOlUxOjJzPD;hQi=>
HCT116	NWfYV2g4SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MoP3O\|IhcHK\|	NYLWPWttSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDQOVMh\XiycnXzd4lv\yCKQ2SxNVYh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IHPlcIx1cXSncj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDDR\|UxKD1iMD63JO69VS5?	MkS2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl2NEG4OFYoRjF7NESxPFQ3RC:jPh?=
HCT116	MX7BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?			M2[zVWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFPUNVE3KGOnbHzzJIJ6KEOnbHzUbZRmei2EbIXlJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOC55IN88UU4>	MnLEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh\|N{CzO\|MoRjF6M{ewN\|c{RC:jPh?=
HEK293T	NIXNTG9HfW6ldHnvckBie3OjeR?=		NVH2WldiOSCqch?=	NV;hPFVYUW6qaXLpeIlwdiCxZjDGUGFINXSjZ3fl[EBJTEGFMjCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBJTUt{OUPUJINmdGy\|IIXzbY5oKGGlZYT5cIF1\WRibInzbY5mKHOrZHWgZ4hicW5iYYOgd5Vje3S{YYTlJIFnfGW{IEGgbJIh[nliY3;sc5JqdWW2cnnjJIRmfGWldHnvckBj[XOnZDDhd5NigSxiSVO1NEA:KDBwN{Sg{txONg>?	M{fzOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7Mki5PFg2Lz5{OUK4PVg5PTxxYU6=
ML1	NXrzd5llSW62aYT1cY9zKGG\|c3H5			M376dGFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIF3MNUBk\WyuczygTWM2OCB;IECuO\|Uh\|ryPLh?=	NETmbJU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUWzOFU{PCd-MUm1N\|Q2OzR:L3G+
HCT116	NH;JPWVCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MnjJN{Bl[Xm\|	M2Hp[mFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFPUNVE3KGOnbHzzJIFnfGW{IEOg[IF6eyCkeTDXV3QuOSCjc4PhfUwhUUN3MDC9JFAvPzZizszNMi=>	NWHUOno2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzNlEzOTVpPkKyN\|IyOjF3PD;hQi=>
U937	MU\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		M1nQblQ5KGi{cx?=	M{fGbGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iVUmzO{Bk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iMD63O{DPxE1w	NEHZN\|M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OESxOVAxQSd-Mki0NVUxODl:L3G+
HCT116	M{nYT2FvfGmycn;sbYZmemG2aY\lJIF{e2G7		MV23NkBpenN?	MlvtRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCKQ2SxNVYh[2WubIOgZZN{\XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKGe{b4f0bEBi\nSncjC3NkBpenNiYomgUXRVNWKjc3XkJIF{e2G7LDDJR\|UxKD1iMD63PEDPxE1w	MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh5NEOyOkc,OjV6N{SzNlY9N2F-
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NB4	NHS2U3FHfW6ldHnvckBie3OjeR?=	M3rid\|UhfU1?	MXSyOEBpenN?	MWjJcoR2[3Srb36gc4YheDJzV1HGNU9EUVBzIHX4dJJme3Orb36gbY4hcHWvYX6gUmI1KGOnbHzzJIF1KDVidV2gZYZ1\XJiMkSgbJJ{KGK7IGfld5Rmem5iYnzveEBidmGueYPpd{4>	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODR7MUS0NEc,OjB2OUG0OFA9N2F-
epithelial cells	MkTjSpVv[3Srb36gZZN{[Xl?	NEPKWW0yKHWP	NVnrSXhZPCxiNjygZY5lKDhiZHH5dy=>	MmDNTY5pcWKrdHnvckBw\iCKRFHDO{BqdiCqdX3hckBpd22xeonnc5V{KE[mZXz0ZVUxQCCycnntZZJ6KGK{b37jbIlidCCncHn0bIVtcWGuIHPlcIx{KGG\|c3Xzd4VlKGG\|IHnuZ5Jm[XOnIHnuJJNpd3K2IHPpdoN2cXRiY4XydoVvfHNiYYSgNUB2VSCob4KgOEwhPixiYX7kJFgh\GG7czDy[YxifGm4ZTD0c{Bkd262cn;sMi=>	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl4Nke4PUc,OTl7Nk[3PFk9N2F-
Hela	NGXZUHVHfW6ldHnvckBie3OjeR?=	NG\tRlYxNjZidV2=	Mn2yNVYhcHK\|	MYrJcohq[mm2aX;uJI9nKEiGQVO2JIlvKGi3bXHuJGhmdGFiY3XscJMh[XO\|ZYPz[YQh[XNiaX7jdoVie2ViaX6geI91[WxibInzbY5mKGGlZYT5cIF1cW:wIHH0JFAvPiC3TTDh[pRmeiBzNjDodpMh[nliaX3teY5w\my3b4Lld4NmdmOnIH3pZ5Jwe2OxcImu	NVjWS\|FvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG2PVY6PTZpPkKxOlk3QTV4PD;hQi=>
U937	NXzoVFlGS2WubDDjfYNt\SCjcoLld5Qh[XO\|YYm=	NXj6VJpSPSC3TR?=	MX2zNEBpenN?	NUHDRlNGS2WubDDjfYNt\SCjcoLld5QhcW5iaIXtZY4hXTl\|NzDj[YxteyCjc4Pld5Nm\CCjczDhZ4N2dXWuYYTpc44h[XRiR{GgdIhie2ViYYSgOUB2VSCjZoTldkA{OCCqcoOgZpkheHKxcHnkbZVuKGmxZHnk[UB{fGGrbnnu[{Bj[XOnZDDmcI94KGO7dH;t[ZRzgS5?	Mo[xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF{MUW2OFcoRjJzMkG1OlQ4RC:jPh?=
epithelial cells	MmjpSpVv[3Srb36gZZN{[Xl?	MkfJOUB2VQ>?		M1XKdmlvcGmkaYTpc44hd2ZiSFTBR{BqdiCqdX3hckBxemmvYYL5JIJzd26laHnhcEBmeGm2aHXsbYFtKGOnbHzzJIF{e2W\|c3XkJIF{KGmwZIXjeIlwdiCxZjDteZRidnRiRnTlcJRiPTB6IFPGWHIheHKxdHXpckBieGmlYXygd5Vz\mGlZTDsc4NidGm8YYTpc44h[XRiNTD1UU4>	NVPpOJdDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5OlY4QDlpPkG5PVY3Pzh7PD;hQi=>
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C127-LT	NWTiN2dYTnWwY4Tpc44h[XO\|YYm=	NVPjOHZ3OSC3TR?=	MoTiNlQhcHK\|	Mm[0TY5pcWKrdHnvckBw\iCKRFHDJIlvKG2xdYPlJGMyOjdvTGSgZ4VtdHNiYYPz[ZN{\WRiYYOgZYN1cX[jdHnvckBw\iCHR1\QJIV5eHKnc4Ppc44h[XRiMTD1UUBi\nSncjCyOEBpenNiYomg[ox2d3Knc3PlcoNmKG2rY4Lvd4NweHlw	MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjl7NkO3Nkc,OjZ7OU[zO\|I9N2F-
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HCT116	M{LSemZ2dmO2aX;uJIF{e2G7	MkfXNVAhfU1?	NH7iSnozPCCqcoO=	MV;Jcohq[mm2aX;uJI9nKEiGQVOyJIlvKGi3bXHuJGhEXDFzNjDj[YxteyCjc4Pld5Nm\CCjczDofZBmemGlZYT5cIF1cW:wIH;mJIhqe3SxbnWgTFMh[XRiMUCgeW0h[W[2ZYKgNlQhcHK\|IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqey5?	MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN{MUKxOUc,OjJ\|MkGyNVU9N2F-
HCT116	M3\HOWZ2dmO2aX;uJIF{e2G7	M{DEUVExKHWP	MWGyOEBpenN?	MWPJcohq[mm2aX;uJI9nKEiGQVOxJIlvKGi3bXHuJGhEXDFzNjDj[YxteyCjc4Pld5Nm\CCjczDofZBmemGlZYT5cIF1cW:wIH;mJIhqe3SxbnWgTFMh[XRiMUCgeW0h[W[2ZYKgNlQhcHK\|IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqey5?	MlnOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ\|MkGyNVUoRjJ{M{KxNlE2RC:jPh?=
TC32	MlvDdWhVWyCjc4PhfS=>			NInsOGNyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiVFOzNkBk\Wyucz6=	NWT5[no1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
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DAOY	Mn;FdWhVWyCjc4PhfS=>			Mne3dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKESDT2mgZ4VtdHNw	NWXtT2xCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
Saos-2	Ml3odWhVWyCjc4PhfS=>			M4XxXZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCVYX;zMVIh[2WubIOu	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
BT-37	NVnwbYM{eUiWUzDhd5NigQ>?			NGfxTXpyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiQmStN\|ch[2WubIOu	M1nLeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
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SK-N-SH	M{LUb5FJXFNiYYPzZZk>			MXzxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhW0tvTj3TTEBk\Wyucz6=	M3O2OFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
BT-12	MXPxTHRUKGG\|c3H5			MlfQdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKEKWLUGyJINmdGy\|Lh?=	Mn71QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
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NB1643	M17LfpFJXFNiYYPzZZk>			MX3xTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhVkJzNkSzJINmdGy\|Lh?=	MmDwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
OHS-50	NX3rXo9weUiWUzDhd5NigQ>?			MWrxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhV0iVLUWwJINmdGy\|Lh?=	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
fibroblast cells	MnzEdWhVWyCjc4PhfS=>			MUXxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5Ih[2:wdILvcEBJcCC5aXzkJJR6eGViZnnido9jdGG\|dDDj[Yxtey5?	M2HoRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
LAN-5	MX3xTHRUKGG\|c3H5			NX\WVllJeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhVEGQLUWgZ4VtdHNw	M4XIT\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
DAOY	NH[4OI5yUFSVIHHzd4F6			MULxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDERW9[KGOnbHzzMi=>	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
Rh41	MnHUdWhVWyCjc4PhfS=>			M1vF[ZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCUaESxJINmdGy\|Lh?=	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
NB-EBc1	M2LnSZFJXFNiYYPzZZk>			MYfxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDORk1GSmNzIHPlcIx{Ng>?	NUDVOIpMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
Rh30	MXjxTHRUKGG\|c3H5			NYLwcplUeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IGLoN\|Ah[2WubIOu	MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
A673	NHqxNpZyUFSVIHHzd4F6			M4fkcZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJGE3PzNiY3XscJMqNg>?	M{XHWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
BT-37	Mn;UdWhVWyCjc4PhfS=>			NY[yN4QzeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhSlRvM{egZ4VtdHNw	NXiwU2U3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
MG 63 (6-TG R)	NFjoZlFyUFSVIHHzd4F6			MVjxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDNS{A3OyBqNj3US{BTMSClZXzsd{4>	MoDBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
Rh30	NH32UXlyUFSVIHHzd4F6			NVzQVJBjeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhWmh\|MDDj[Yxtey5?	NIL2N\|I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
U-2 OS	NYjZXo05eUiWUzDhd5NigQ>?			MYTxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDVMVIhV1NiY3XscJMv	NV3WUoxYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
OHS-50	MnjDdWhVWyCjc4PhfS=>			NHraOI5yUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBQUFNvNUCgZ4VtdHNw	M1TTVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
Rh41	NWHpNZFneUiWUzDhd5NigQ>?			MUfxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDSbFQyKGOnbHzzMi=>	NHLxfpU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
RD	M2jpWJFJXFNiYYPzZZk>			MWfxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDSSEBk\Wyucz6=	M4\IWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SJ-GBM2	NEHXeZdyUFSVIHHzd4F6			NEDFUplyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiU1qtS2JOOiClZXzsd{4>	M3G0O\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SK-N-MC	NIDKO\|lyUFSVIHHzd4F6			NIfpOVZyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiU1utUk1OSyClZXzsd{4>	M4\oc\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
NB-EBc1	M4XPepFJXFNiYYPzZZk>			MWXxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhVkJvRVLjNUBk\Wyucz6=	MkO5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
LAN-5	MlPydWhVWyCjc4PhfS=>			MVnxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhVEGQLUWgZ4VtdHNw	M{DxXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
Rh18	NHfwUWxyUFSVIHHzd4F6			Mkm3dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKFKqMUigZ4VtdHNw	M3PyOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
NB1643	M2HmfpFJXFNiYYPzZZk>			MnqxdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgUmIyPjR\|IHPlcIx{Ng>?	Mlm3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
SK-N-MC	MnvldWhVWyCjc4PhfS=>			M3va[JFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJHNMNU5vTVOgZ4VtdHNw	M1PLTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SJ-GBM2	NVXnVWxbeUiWUzDhd5NigQ>?			NH31OWRyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBUUi2JQl2yJINmdGy\|Lh?=	MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
TC32	M4LRU5FJXFNiYYPzZZk>			MYnxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDUR\|MzKGOnbHzzMi=>	MnjlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
Rh18	NH\1ZWxyUFSVIHHzd4F6			M2XOfJFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJHJpOThiY3XscJMv	MnXnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
Saos-2	M3H4cJFJXFNiYYPzZZk>			NHH3VnByUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBU[W:\|LUKgZ4VtdHNw	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
HeLa	M{LuOWZ2dmO2aX;uJIF{e2G7	NFjIW2gyKHWP	Mnn3OkBpenN?	NFX3T2lKdmirYnn0bY9vKG:oIFjERWMyN0iGQVOyM2hFSUN\|IHnuJIh2dWGwIFjlUIEh[2WubIOgZZN{\XO\|ZXSgZZMhcW6lcnXhd4UhcW5iaX70doFk\WyudXzhdkBi[2W2eXytbIl{fG:wZTDIOEBt\X[nbIOgZZQhOSC3TTDh[pRmeiB4IHjyd{BjgSCZZYP0[ZJvKGKub4SgZY5idHm\|aYOu	M3TTOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7N{i3NlYzLz5{OUe4O\|I3OjxxYU6=
MV4-11	M2TuNGFxd3C2b4Ppd{Bie3OjeR?=	MUe1JJVO	MV2yOEB1dyB2ODDodpM>	MX3JcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKE2YND2xNUBk\WyuczDheEA2KHWPIHHmeIVzKDJ2IITvJFQ5KGi{czDifUBCdm6neHnuJHYuWElic4ThbY5qdmdiYnHz[YQh\myxdzDjfZRwdWW2comu	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTd\|OEm1N{c,Ojl5M{i5OVM9N2F-
MV4-11	MV\GeY5kfGmxbjDhd5NigQ>?	NYT6Zm9{OjByIH7N	NGjoW20zPCCqcoO=	M37keGlvcGmkaYTpc44hd2ZiY3zhd5MhOSCKRFHDJIlvKGi3bXHuJG1XPC1zMTDj[YxteyCjc4Pld5Nm\CCjczDofZBmemGlZYT5cIF1cW:wIH;mJIhqe3SxbnWgTFMh[XRiMkCwJI5OKGGodHXyJFI1KGi{czDifUBY\XO2ZYLuJIJtd3RiYX7hcJl{cXNw	NXmwdld2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm3N\|g6PTNpPkK5O\|M5QTV\|PD;hQi=>
HL60	NEHuT\|VCeG:ydH;zbZMh[XO\|YYm=	MoDZOUB2VQ>?	MWi0PEBpenN?	Mn7mTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCKTE[wJINmdGy\|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKHC{b3Phd5Bie2VvMzDs[ZZmdCCjdDC1JJVOKGGodHXyJFQ5KGi{czDifUBY\XO2ZYLuJIJtd3RiYX7hcJl{cXNw	MnXhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2MUWwNFkoRjJ6NEG1NFA6RC:jPh?=
HL60	NH21cpNCeG:ydH;zbZMh[XO\|YYm=	MlHxOUB2VQ>?	NWP1e5pxPDhiaILz	MWXJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKEiONkCgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4h[2ynYY\l[EBk[XOyYYPlMVMhdGW4ZXygZZQhPSC3TTDh[pRmeiB2ODDodpMh[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nzMi=>	M3;3eVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NEG1NFA6Lz5{OESxOVAxQTxxYU6=
HL60	NFv5UI5CeG:ydH;zbZMh[XO\|YYm=	NFTBPJc2KHWP	MlriOFghcHK\|	MmnSTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCKTE[wJINmdGy\|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGOuZXH2[YQhWEGUUDDs[ZZmdCCjdDC1JJVOKGGodHXyJFQ5KGi{czDifUBY\XO2ZYLuJIJtd3RiYX7hcJl{cXNw	NVPEdWtVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0NVUxODlpPkK4OFE2ODB7PD;hQi=>
MV4-11	NHfneGtE\WyuIHP5Z4xmKGG{cnXzeEBie3OjeR?=	MlL4OUB2VQ>?	NVKxRWZNOjRiaILz	MmHHR4VtdCCleXPs[UBienKnc4SgbY4hcHWvYX6gUXY1NTFzIHPlcIx{KGG\|c3Xzd4VlKGG\|IHHjZ5VufWyjdHnvckBifCC\|dXKtS\|EheGijc3WgZZQhPSC3TTDh[pRmeiB{NDDodpMh[nlicILvdIllcXWvIHnv[Ill\SC\|dHHpcolv\y2kYYPl[EBndG:5IHP5eI9u\XS{aXOgcYV1cG:mLh?=	NYj4WGQ2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1PFk1PDFpPkK5OVg6PDRzPD;hQi=>
HEL	M4HIeGNmdGxiY4njcIUh[XK{ZYP0JIF{e2G7	MWW1JJVO	NXP0dHViOjRiaILz	NEDBPYxE\WyuIHP5Z4xmKGG{cnXzeEBqdiCqdX3hckBJTUxiY3XscJMh[XRiNTD1UUBi\nSncjCyOEBpenNiYomgdJJweGmmaYXtJIlw\GmmZTDzeIFqdmmwZz3iZZNm\CCobH;3JIN6fG:vZYTybYMhdWW2aH;kMi=>	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTV6OUS0NUc,Ojl3OEm0OFE9N2F-
Jurkat	NXfEe2ZQS2WubDDjfYNt\SCjcoLld5Qh[XO\|YYm=	M2niWFUhfU1?	M3jpNVI1KGi{cx?=	MkPvR4VtdCCleXPs[UBienKnc4SgbY4hcHWvYX6gTpVzc2G2IHPlcIx{KGG2IEWgeW0h[W[2ZYKgNlQhcHK\|IHL5JJBzd3CrZHn1cUBqd2SrZHWgd5RicW6rbnetZoF{\WRiZnzve{BkgXSxbXX0dolkKG2ndHjv[E4>	M1LxVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUi5OFQyLz5{OUW4PVQ1OTxxYU6=
MV4-11	M{PtT2Z2dmO2aX;uJIF{e2G7	NVLvc25vPSC3TR?=	NV;ycYpROjRiaILz	MVHJcohq[mm2aX;uJI9nKGOuYYPzJFEhUESDQzDpckBpfW2jbjDNWlQuOTFiY3XscJMh[XO\|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJIhqe3SxbnWgbJlx\XKjY3X0fYxifGmxbjDheEA2KHWPIHHmeIVzKDJ2IHjyd{BjgSCZZYP0[ZJvKGKub4SgcYV1cG:mLh?=	NI\YUG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUW4PVQ1OSd-Mkm1PFk1PDF:L3G+
LNCAP	NFjoZ3RHfW6ldHnvckBie3OjeR?=	MXmxNEB2VQ>?	MVKyOEBpenN?	M3[0cmlvcGmkaYTpc44hd2ZiSFTBR\|YhcW5iaIXtZY4hVE6FQWCgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCGSGStbY5lfWOnZDDhcJBp[S22dXL1cIlvKGSnYXPleJlt[XSrb36gZpkhdWWjc4XybY5oKGmwY4LlZZNmKGmwIHHsdIhiNXS3YoXsbY4h[WOndInsZZRqd25iYYSgNVAhfU1ibXXhd5Vz\WRiYX\0[ZIhOjRiaILzJJJmdGG2aY\lJJRwKGOxboTyc4wv	M{DNSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{G3OVQ1Lz5{N{exO\|U1PDxxYU6=

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	AcH3 / AcH4 / HDAC1 / HDAC2 / HDAC3; PubMed: 24203492 Pharm Res HCT-15 or fresh primary NK cells were treated with entinostat for 24 h, and AcH3, AcH4, and HDAC1, 2, and 3 were detected by Western blotting. Cleaved PARP; PubMed: 19148581 J Neurooncol Induction of PARP cleavage in Daoy cells upon exposure to MS-275 was demonstrated by Western blot analyses using antibodies that recognize the cleaved 89 kDa PARP protein. Pan-Actin (45 kDa) was used as a loading control. Caspase 8 ; PubMed: 19148581 J Neurooncol Cleavage of pro-Caspase-8 was demonstrated by Western blotting with extracts prepared from Daoy cells treated with 2.5 µM MS-275 for various time periods. Antibodies specific to human Caspase-8 or the loading control, pan-Actin were used to probe protein expression. DR4 / DR5; PubMed: 19148581 J Neurooncol Western blotting to detect DR4 and DR5 expression upon treatment of Daoy cells with 2.5 µM MS-275 for 4, 8 and 24 h. TopoIIα / TopoIIβ; PubMed: 21254166 Hepatology Upper panel, concentration-dependent effects of AR42, MS-275 and vorinostat on the expression of topoIIα versus topoIIβ after 48 h. Lower panel, time-dependent effect of 0.5 μM AR42 and 5 μM MS-275 on topoIIα versus topoIIβ expression in PLC-5 cells.	24203492 19148581 21254166
Immunofluorescence	phalloidin / snail; PubMed: 29855565 Sci Rep (C) Effect of MS-275 treatment on Snail expression and localization. MCs (mesothelial cells) were treated with MS-275 (250 nM), or DMSO for 48 hr and then stimulated with TGFβ1 (2 ng/ml) for 24 h before processing for immunofluorescence with a monoclonal antibody against Snail. Cell nuclei are shown in blue (Hoechst 33342). Confocal images are shown from one representative experiment of three performed. DR4 / DR5; PubMed: 19148581 J Neurooncol Flow Cytometry to measure cell surface expression of FAS, DR4 and DR5 using PE-labeled antibodies. Cells stained with isotype matched anti-human IgG antibodies served as controls. H3K4Me3 / H3K9Me3; PubMed: 22468166 Mol Cell Pharmacol Immunocytochemical analysis of the effects of AR42, SAHA, and MS-275 at the indicated concentrations on H3K4Me3 (upper panels) and H3K9Me3 (lower panels) after 24 h of treatment in LNCaP cells.	29855565 19148581 22468166
Growth inhibition assay	Cell proliferation; PubMed: 24203492 Pharm Res (A) HCT-15 cells were cultured in indicated concentrations of entinostat for up to 72 h, and proliferation determined by MTT assay as indicated. (B) HCT-15, CCH-OS-D, COL and HOS cells were cultured in indicated concentrations of entinostat for 72 h, and viable cell number was determined using the Vi-cell assay and proliferation index calculated. (C) Freshly-isolated human NK cells were cultured in indicated concentrations of entinostat for up to 72 h, and viability was assessed by flow cytometry for 7-AAD uptake. , P < 0.05, ; P ≤ 0.01; **, P ≤ 0.001 Cell viability; PubMed: 28969017 Oncotarget PANC-1, MIA PaCa-2, BxPC3, CFPAC-1, SUIT2 and SUIT2 Clone 1 cells were plated at a density of 3-5×103 per well in 96-well microtiter plates, allowed to adhere overnight and incubated for 72 hours in the presence of variable concentrations of entinostat (0-100μM). Cell viability was determined by XTT assays. The data presented are the mean values from triplicate wells from two independent experiments ±SE.	24203492 28969017
ELISA	GCP-2 / MCP-2 / MIF ; PubMed: 24241152 Molecules MS-275 and SAHA suppressed the secretion of GCP-2, MCP-2 and MIF in E11 cells. (A) GCP suppression. (B) MCP-2 suppression. (C) MIF suppression. E11 cells were incubated with HDAC inhibitors at various concentrations for 1 h before they were stimulated by LPS. 24 h later, the secretion of GCP-2, MCP-2 and MIF were quantified by ELISA (n = 8). Bars show the mean and SD in (A–C).	24241152

体内研究

MS-275按49 mg/kg剂量作用于除了HCT-15的人类移植瘤都显示出强抗癌活性。^[1]MS-275促进恶性实体瘤和恶性血液病的治疗可能性，及生理和畸变基因表达的调节。^[4]MS-275和IL-2联用，作用于肾细胞癌显示出强抗癌活性，因为降低调节性T细胞和增强脾细胞的表达。^[5]

激酶实验：^[6]	- 合并标准HDAC实验: 用HDAC buffer按1:6稀释鼠肝内的酶。重组人类HDACs按1:4稀释在HDAC buffer中。用于标准HDAC实验，60 μl HDAC buffer和10 μl 稀释的酶溶液在30^oC混合。在HDAC buffer中加入30 μl基底液开始HDAC反应，随后在30^oC下温育30分钟。加入100 μl胰蛋白酶溶液终止反应，胰蛋白酶溶液由溶于50 mM Tris-HCl（pH 为8.0）的10 mg/ml 胰蛋白酶, 100 mM NaCl,及 2 μM TSA组成。30^oC下温育20分钟，通过测定460纳米(λ_ex = 390 nm)处的荧光监测AMC的释放。使用释放的AMC校准荧光强度。用于标准时间过程实验，在初始100 μl HDAC 反应中加入20 pmol 基底物。2-50 pmol 基底物的酶法分析产物获得荧光AMC，通过测量这种荧光AMC来测定 K_m值和 V_max值。使用Hanes 图分析实验数据。记录的AMC信号是针对没有酶而有buffer和基底物的空白区。
细胞实验：^[2]	- 合并 Cell lines: A2780, Calu-3, HL-60, K562, St-4, HT-29, KB-3-1, Capan-1, 4-1St和HCT-15细胞 Concentrations: 10 μM 左右 Incubation Time: 3天 Method: 5×10³个肿瘤细胞接种到96孔板上，加入梯度浓度MS-275培养三天。细胞用0.1 mg/mL中性红在CO₂反应器中染色1小时，测定中性红与50 μL乙醇和150 μL 0.1 M Na₂HPO₄溶解后的OD540,测定IC50值。 (Only for Reference)
动物实验：^[1]	- 合并 Animal Models: 侧腹皮下注射A2780, HT-29, HTC-15, KB-3-1, 4-1St, St-4, Capan-1和Calu-3细胞的裸鼠 Dosages: 12.3, 24.5和49 mg/kg Administration: 每天口服处理一次，每周进行5天，持续4周。 (Only for Reference)

参考文献

- 合并

溶解度 (25°C)

体外	DMSO	75 mg/mL (199.25 mM)
	Water	Insoluble
	Ethanol	Insoluble
体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： 2% DMSO+30% PEG 300+ddH2O	10mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

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