Entinostat (MS-275)

For research use only. Not for use in humans.

目录号:S1053 别名: SNDX-275 中文名称:恩替诺特

Entinostat (MS-275) Chemical Structure

CAS No. 209783-80-2

Entinostat (MS-275, SNDX-275)强烈抑制HDAC1HDAC3,无细胞试验中IC50分别为0.51 μM和1.7 μM,抑制作用强于HDACs 4, 6, 8,和10。Entinostat可诱导自噬和凋亡。Phase 3。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 746.45 现货
RMB 794.43 现货
RMB 2234.07 现货
RMB 6301.79 现货
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客户使用Selleck生产的Entinostat (MS-275)发表文献337篇:

产品安全说明书

HDAC抑制剂选择性比较

生物活性

产品描述 Entinostat (MS-275, SNDX-275)强烈抑制HDAC1HDAC3,无细胞试验中IC50分别为0.51 μM和1.7 μM,抑制作用强于HDACs 4, 6, 8,和10。Entinostat可诱导自噬和凋亡。Phase 3。
靶点
HDAC1 [2]
(Cell-free assay)
HDAC3 [2]
(Cell-free assay)
0.51 μM 1.7 μM
体外研究

MS-275通过作用于2′-氨基而抑制HDACs。MS-275作用于 K562细胞,诱导 p21WAF1/CIP1和凝溶胶蛋白的累积。MS-275作用于A2780细胞,可以降低S期细胞,提高G1期细胞。 MS-275通过抑制HAD而抑制人类肿瘤细胞系,包括 A2780, Calu-3, HL-60, K562, St-4, HT-29, KB-3-1, Capan-1, 4-1St和 HCT-15细胞增殖, IC50 为41.5 nM到4.71 μM。[1]MS-275抑制HDACs,作用于HDAC1和 HDAC3时IC50 分别为0.51 μM和1.7 μM。而对其他的HDACs没有抑制效果,如HDAC4, 6, 8和10。[2]MS-275有效抑制人类白血病和淋巴癌细胞,包括U937, HL-60, K562, 和Jurkat。MS-275可以诱导U937细胞p21CIP1/WAF1 调节的生长和变异Marker (CD11b)的表达。MS-275降低cyclin D1和抗凋亡蛋白Mcl-1与XIAP的表达。[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
SCC-3 M1fQPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7nRYlKSzVyPUCuNFYyKM7:TR?= MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyO|c2QS9pPmPBUmdGWjxxYU6=
ALL-PO NYL5WpZ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{T2O2lEPTB;MD6wOlM2PSEQvF2= NWTXOWN7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjd5NUmvK|5USU6JRWK8M4E,
697 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoS1TWM2OD1yLkC5PVc3KM7:TR?= NH7KRlQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPzd3OT:nQnNCVkeHUkyvZV4>
NCI-H748 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTBwMUCzN|Qh|ryP NWDIb4FRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjd5NUmvK|5USU6JRWK8M4E,
NKM-1 NUnwNYJPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;CTWM2OD1yLkGwPVEzKM7:TR?= MnTCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlc4PTlxJ{7TRW5ITVJ:L3G+
ES1 MmfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGe3PGVKSzVyPUCuNVEzPTVizszN NYDV[4t2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjd5NUmvK|5USU6JRWK8M4E,
NCI-H1963 M1XNNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXEXmNKSzVyPUCuNVE2PzlizszN MoPRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlc4PTlxJ{7TRW5ITVJ:L3G+
NCI-H1417 NIfnTWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwMUK5O|Qh|ryP M{W0[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI4PzV7Lze+V2FPT0WUPD;hQi=>
NEC8 MlfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHDTWM2OD1yLkGzOVI4KM7:TR?= NWjadYhGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjd5NUmvK|5USU6JRWK8M4E,
CRO-AP2 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTBwMU[4PFkh|ryP MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyO|c2QS9pPmPBUmdGWjxxYU6=
A3-KAW M4rZTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jzc2lEPTB;MD6xO|YzPyEQvF2= NH65N5k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPzd3OT:nQnNCVkeHUkyvZV4>
SF539 NWLSTmVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zQemlEPTB;MD6xPVU6OyEQvF2= Mon0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlc4PTlxJ{7TRW5ITVJ:L3G+
NOS-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwMUm2NVkh|ryP NVLWc41VRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjd5NUmvK|5USU6JRWK8M4E,
NTERA-S-cl-D1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37rTmlEPTB;MD6yNFEyOyEQvF2= NG\USZI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPzd3OT:nQnNCVkeHUkyvZV4>
COR-L88 M1jaW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfpTWM2OD1yLkKyPVU6KM7:TR?= NUP6T5ViRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjd5NUmvK|5USU6JRWK8M4E,
EM-2 NU\UcZdyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjyU3I3UUN3ME2wMlI1ODd7IN88US=> MkLHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlc4PTlxJ{7TRW5ITVJ:L3G+
KARPAS-45 MlzrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXGWWdKSzVyPUCuNlc5OzNizszN NWPKcnlzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjd5NUmvK|5USU6JRWK8M4E,
DSH1 MoHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwMki3NFgh|ryP M3HNblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI4PzV7Lze+V2FPT0WUPD;hQi=>
HT-144 Ml\sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\KeXRKSzVyPUCuN|AzPTZizszN M3rYfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI4PzV7Lze+V2FPT0WUPD;hQi=>
ATN-1 NX7Ld3Q2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPXSnd3UUN3ME2wMlMxPTd4IN88US=> NHO5UoY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPzd3OT:nQnNCVkeHUkyvZV4>
HEL M{nsUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFv0W3pKSzVyPUCuN|E{PDhizszN MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyO|c2QS9pPmPBUmdGWjxxYU6=
NB12 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17h[GlEPTB;MD6zNVc2PiEQvF2= NIfBZ3Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPzd3OT:nQnNCVkeHUkyvZV4>
LU-139 MnTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTBwM{O1NUDPxE1? MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyO|c2QS9pPmPBUmdGWjxxYU6=
J-RT3-T3-5 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nqVmlEPTB;MD6zN|cyPiEQvF2= M{\lZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI4PzV7Lze+V2FPT0WUPD;hQi=>
MOLT-13 MlW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTKcYZZUUN3ME2wMlM{QDFizszN MnPnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlc4PTlxJ{7TRW5ITVJ:L3G+
SR MkTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHP1Zo1KSzVyPUCuN|QzPjFizszN NF7xdpE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPzd3OT:nQnNCVkeHUkyvZV4>
CMK MlH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLjTWM2OD1yLkO1O|I4KM7:TR?= MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyO|c2QS9pPmPBUmdGWjxxYU6=
ES8 MniyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnX1TWM2OD1yLkO2NFIzKM7:TR?= M4XWblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI4PzV7Lze+V2FPT0WUPD;hQi=>
LB647-SCLC NWPm[HpXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrFZYNKSzVyPUCuN|Y4OyEQvF2= NVfsVlhyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjd5NUmvK|5USU6JRWK8M4E,
TE-8 M3;hVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\y[ZdKSzVyPUCuN|Y6OzVizszN NFHkUng9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPzd3OT:nQnNCVkeHUkyvZV4>
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DEL NUPIcHd[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIr5blRKSzVyPUCuN|c1QDdizszN MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyO|c2QS9pPmPBUmdGWjxxYU6=
ARH-77 Mn2yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGG5SJBKSzVyPUCuN|gyQTNizszN M3TVdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI4PzV7Lze+V2FPT0WUPD;hQi=>
NCCIT M4rEemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTBwM{i2OFkh|ryP MmPvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlc4PTlxJ{7TRW5ITVJ:L3G+
RPMI-8402 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYCyZ3pxUUN3ME2wMlM5PzBzIN88US=> NXXUO21tRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjd5NUmvK|5USU6JRWK8M4E,
MONO-MAC-6 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEG1U5JKSzVyPUCuN|g4PzZizszN MmmyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlc4PTlxJ{7TRW5ITVJ:L3G+
SK-MM-2 MnLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLhO|A3UUN3ME2wMlM6QDZ6IN88US=> NYHEc3d[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjd5NUmvK|5USU6JRWK8M4E,
CHP-126 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEiwfmlKSzVyPUCuOFAzOzFizszN M{fzSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI4PzV7Lze+V2FPT0WUPD;hQi=>
A101D MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX23VnAyUUN3ME2wMlQxOyEQvF2= M2myVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI4PzV7Lze+V2FPT0WUPD;hQi=>
SCH NYK0XIxFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLldFQ{UUN3ME2wMlQxOzR{IN88US=> NEeyT2Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPzd3OT:nQnNCVkeHUkyvZV4>
NMC-G1 NF7qcWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfqT2dOUUN3ME2wMlQxOzZ5IN88US=> NF36fW09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPzd3OT:nQnNCVkeHUkyvZV4>
NCI-H209 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvITWM2OD1yLkSwOlE{KM7:TR?= MmnNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlc4PTlxJ{7TRW5ITVJ:L3G+
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LP-1 NVfnZlNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TxdGlEPTB;MT6yPVk1PyEQvF2= MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyO|c2QS9pPmPBUmdGWjxxYU6=
LS-411N Mm\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jGSWlEPTB;MT6zNFk6QCEQvF2= M1HMOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI4PzV7Lze+V2FPT0WUPD;hQi=>
CAL-148 M36we2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jUSWlEPTB;MT6zNlU1OiEQvF2= NY[2V5lxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjd5NUmvK|5USU6JRWK8M4E,
NCI-H2171 MmHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17VOmlEPTB;MT6zOFUxOiEQvF2= MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyO|c2QS9pPmPBUmdGWjxxYU6=
JiyoyeP-2003 NYDBdFdtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFntbJJKSzVyPUGuN|U{QSEQvF2= MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyO|c2QS9pPmPBUmdGWjxxYU6=
NCI-H2107 M3vnT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfqTWM2OD1zLkO1PFg{KM7:TR?= MkjCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlc4PTlxJ{7TRW5ITVJ:L3G+
BB30-HNC MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTFwM{i5O|gh|ryP NXHocW5yRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjd5NUmvK|5USU6JRWK8M4E,
K-562 M3;0WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHpTWM2OD1zLkO5NlE6KM7:TR?= NWi3VoNkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjd5NUmvK|5USU6JRWK8M4E,
PSN1 NVvnXYx4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTySpNKSzVyPUGuOFIzQDdizszN M3f5O|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI4PzV7Lze+V2FPT0WUPD;hQi=>
HCC2157 M3LEeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{Czc2lEPTB;MT60NlY6OSEQvF2= NXvvbY9GRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjd5NUmvK|5USU6JRWK8M4E,
SBC-1 NXThV4tnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnZTWM2OD1zLkSyO|QyKM7:TR?= NInjPY49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPzd3OT:nQnNCVkeHUkyvZV4>
MC116 M3\yVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHuWWlKSzVyPUGuOFM3OTVizszN NYrDZ|VORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjd5NUmvK|5USU6JRWK8M4E,
KARPAS-422 NX;lTVlzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojCTWM2OD1zLkS1N|U5KM7:TR?= NXHxfHJbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjd5NUmvK|5USU6JRWK8M4E,
LB996-RCC M{HTeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LOfWlEPTB;MT60O|ExOyEQvF2= Ml34QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlc4PTlxJ{7TRW5ITVJ:L3G+
MSTO-211H M4rIXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTFwNEe5PFch|ryP MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyO|c2QS9pPmPBUmdGWjxxYU6=
BT-474 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXiRW1KSzVyPUGuOVE4PjRizszN NUHuXJl3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjd5NUmvK|5USU6JRWK8M4E,
A388 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTFwNUG5OFUh|ryP NUHJRnFNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjd5NUmvK|5USU6JRWK8M4E,
SJSA-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33BUmlEPTB;MT61NlI3KM7:TR?= M{LUTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI4PzV7Lze+V2FPT0WUPD;hQi=>
COLO-829 NV3lW3dwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXToOYJvUUN3ME2xMlU{PTZ2IN88US=> NGfMVmk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPzd3OT:nQnNCVkeHUkyvZV4>
KM-H2 NVnzZolPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHtTWM2OD1zLkW2Olch|ryP M3vVTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI4PzV7Lze+V2FPT0WUPD;hQi=>
GR-ST MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDlOpFXUUN3ME2xMlU3QDJizszN MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyO|c2QS9pPmPBUmdGWjxxYU6=
RPMI-8866 M3u4emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXYTWM2OD1zLk[wNVQ1KM7:TR?= MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyO|c2QS9pPmPBUmdGWjxxYU6=
KG-1 NUH1fGI5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTFwNkG5NFEh|ryP MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyO|c2QS9pPmPBUmdGWjxxYU6=
NCI-H82 M2TGOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYexRXhtUUN3ME2xMlY{PDB4IN88US=> NFK3coc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPzd3OT:nQnNCVkeHUkyvZV4>
LB1047-RCC NYDlPZNjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzRTWM2OD1zLk[zOFU6KM7:TR?= NEC1Opk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPzd3OT:nQnNCVkeHUkyvZV4>
KM12 MoTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrzcGFbUUN3ME2xMlY1PyEQvF2= MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyO|c2QS9pPmPBUmdGWjxxYU6=
NB5 NGjSWJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTFwNkW2O|ch|ryP MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyO|c2QS9pPmPBUmdGWjxxYU6=
HDLM-2 NGLwS4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\xTWM2OD1zLk[4NlgyKM7:TR?= M2DES|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI4PzV7Lze+V2FPT0WUPD;hQi=>
KU812 NHrIXFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTFwNkm2NFUh|ryP M4jJflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI4PzV7Lze+V2FPT0WUPD;hQi=>
DB MoG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTVS4IxUUN3ME2xMlcxOzV|IN88US=> MkjLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlc4PTlxJ{7TRW5ITVJ:L3G+
HD-MY-Z NXfNbJN7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7sOHFDUUN3ME2xMlc2OjN2IN88US=> NXfNUVhMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjd5NUmvK|5USU6JRWK8M4E,
KURAMOCHI MnLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vGPGlEPTB;MT63O|IxPyEQvF2= M{jCcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI4PzV7Lze+V2FPT0WUPD;hQi=>
ETK-1 NYjvRYdzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zqb2lEPTB;MT63PFg4QSEQvF2= MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyO|c2QS9pPmPBUmdGWjxxYU6=
SK-UT-1 NGfwXWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYW0b5ZwUUN3ME2xMlc6Ozh6IN88US=> MmW0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlc4PTlxJ{7TRW5ITVJ:L3G+
HUTU-80 NWe3NVhwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjTTW5KSzVyPUGuO|k2ODhizszN NUHyd|llRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjd5NUmvK|5USU6JRWK8M4E,
ES7 M2rHXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vSW2lEPTB;MT64NFMxOiEQvF2= NEC5c5c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPzd3OT:nQnNCVkeHUkyvZV4>
SW872 MlXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnkTWM2OD1zLkixN|k2KM7:TR?= NILGUJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPzd3OT:nQnNCVkeHUkyvZV4>
TK10 M{\lTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTFwOEOxNFgh|ryP MnXSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlc4PTlxJ{7TRW5ITVJ:L3G+
LB831-BLC NUD3Z3NPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTFwOEO1OlMh|ryP MkT4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlc4PTlxJ{7TRW5ITVJ:L3G+
TE-9 M2DHPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmK1TWM2OD1zLki0OFIzKM7:TR?= MoXvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlc4PTlxJ{7TRW5ITVJ:L3G+
MLMA NYPpdG1[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rJdmlEPTB;MT64PFI{PCEQvF2= MoniQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlc4PTlxJ{7TRW5ITVJ:L3G+
D-542MG NILU[XNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTFwOEmzO|Mh|ryP MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyO|c2QS9pPmPBUmdGWjxxYU6=
EW-16 NGfYPXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTFwOUK3NkDPxE1? MoDOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlc4PTlxJ{7TRW5ITVJ:L3G+
LOXIMVI NEL3VplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fpPWlEPTB;MT65N|I5KM7:TR?= MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyO|c2QS9pPmPBUmdGWjxxYU6=
GB-1 NHjpfW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTFwOUO4OlYh|ryP M{fUbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI4PzV7Lze+V2FPT0WUPD;hQi=>
IST-SL2 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnoU3RyUUN3ME2yMlAxOjZ{IN88US=> NFfBT2I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPzd3OT:nQnNCVkeHUkyvZV4>
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MV4-11 NWP0dlliSXCxcITvd4l{KGG|c3H5 MnrYOUB2VQ>? NX3yUpNpOjRidH:gOFghcHK| MU\JcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKE2YND2xNUBk\WyuczDheEA2KHWPIHHmeIVzKDJ2IITvJFQ5KGi{czDifUBCdm6neHnuJHYuWElic4ThbY5qdmdiYnHz[YQh\myxdzDjfZRwdWW2comu M134XlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7N{O4PVU{Lz5{OUezPFk2OzxxYU6=
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HL60 MYHBdI9xfG:|aYOgZZN{[Xl? MmPpOUB2VQ>? Mn\pOFghcHK| MX\JcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKEiONkCgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4heHKxY3HzdIF{\S1|IHzleoVtKGG2IEWgeW0h[W[2ZYKgOFghcHK|IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqey5? M3rNfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NEG1NFA6Lz5{OESxOVAxQTxxYU6=
HL60 NIDLWJZCeG:ydH;zbZMh[XO|YYm= M{HGPFUhfU1? NYTDVnB[PDhiaILz MVvJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKEiONkCgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4h[2ynYY\l[EBk[XOyYYPlMVMhdGW4ZXygZZQhPSC3TTDh[pRmeiB2ODDodpMh[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nzMi=> MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDRzNUCwPUc,Ojh2MUWwNFk9N2F-
HL60 NY[wUmYySXCxcITvd4l{KGG|c3H5 MlPXOUB2VQ>? NGnGO5M1QCCqcoO= M4PN[Glv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iSFy2NEBk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiClbHXheoVlKFCDUmCgcIV3\WxiYYSgOUB2VSCjZoTldkA1QCCqcoOgZpkhX2W|dHXyckBjdG:2IHHuZYx6e2m|Lh?= NHnNS5c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OESxOVAxQSd-Mki0NVUxODl:L3G+
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MV4-11 NF7lR4VHfW6ldHnvckBie3OjeR?= NYXxPZJzPSC3TR?= NV[wUYxGOjRiaILz MV;Jcohq[mm2aX;uJI9nKGOuYYPzJFEhUESDQzDpckBpfW2jbjDNWlQuOTFiY3XscJMh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJIhqe3SxbnWgbJlx\XKjY3X0fYxifGmxbjDheEA2KHWPIHHmeIVzKDJ2IHjyd{BjgSCZZYP0[ZJvKGKub4SgcYV1cG:mLh?= M{n5TlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUi5OFQyLz5{OUW4PVQ1OTxxYU6=
LNCAP M{nBXmZ2dmO2aX;uJIF{e2G7 NG\oWmMyOCC3TR?= M1n2dVI1KGi{cx?= NYDkVXpqUW6qaXLpeIlwdiCxZjDISGFEPiCrbjDoeY1idiCOTlPBVEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFTIWE1qdmS3Y3XkJIFteGijLYT1ZpVtcW5iZHXhZ4V1gWyjdHnvckBjgSCvZXHzeZJqdmdiaX7jdoVie2ViaX6gZYxxcGFvdIXieYxqdiCjY3X0fYxifGmxbjDheEAyOCC3TTDt[YF{fXKnZDDh[pRmeiB{NDDodpMhemWuYYTpeoUhfG9iY3;ueJJwdC5? NFnvW3k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{exO|U1PCd-Mke3NVc2PDR:L3G+

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
AcH3 / AcH4 / HDAC1 / HDAC2 / HDAC3; 

PubMed: 24203492     


HCT-15 or fresh primary NK cells were treated with entinostat for 24 h, and AcH3, AcH4, and HDAC1, 2, and 3 were detected by Western blotting. 

Cleaved PARP; 

PubMed: 19148581     


Induction of PARP cleavage in Daoy cells upon exposure to MS-275 was demonstrated by Western blot analyses using antibodies that recognize the cleaved 89 kDa PARP protein. Pan-Actin (45 kDa) was used as a loading control.

Caspase 8 ; 

PubMed: 19148581     


Cleavage of pro-Caspase-8 was demonstrated by Western blotting with extracts prepared from Daoy cells treated with 2.5 µM MS-275 for various time periods. Antibodies specific to human Caspase-8 or the loading control, pan-Actin were used to probe protein expression.

DR4 / DR5; 

PubMed: 19148581     


Western blotting to detect DR4 and DR5 expression upon treatment of Daoy cells with 2.5 µM MS-275 for 4, 8 and 24 h.

TopoIIα / TopoIIβ; 

PubMed: 21254166     


Upper panel, concentration-dependent effects of AR42, MS-275 and vorinostat on the expression of topoIIα versus topoIIβ after 48 h. Lower panel, time-dependent effect of 0.5 μM AR42 and 5 μM MS-275 on topoIIα versus topoIIβ expression in PLC-5 cells.

24203492 19148581 21254166
Immunofluorescence
phalloidin / snail; 

PubMed: 29855565     


(C) Effect of MS-275 treatment on Snail expression and localization. MCs (mesothelial cells) were treated with MS-275 (250 nM), or DMSO for 48 hr and then stimulated with TGFβ1 (2 ng/ml) for 24 h before processing for immunofluorescence with a monoclonal antibody against Snail. Cell nuclei are shown in blue (Hoechst 33342). Confocal images are shown from one representative experiment of three performed.

DR4 / DR5; 

PubMed: 19148581     


Flow Cytometry to measure cell surface expression of FAS, DR4 and DR5 using PE-labeled antibodies. Cells stained with isotype matched anti-human IgG antibodies served as controls.

H3K4Me3 / H3K9Me3; 

PubMed: 22468166     


Immunocytochemical analysis of the effects of AR42, SAHA, and MS-275 at the indicated concentrations on H3K4Me3 (upper panels) and H3K9Me3 (lower panels) after 24 h of treatment in LNCaP cells.

29855565 19148581 22468166
Growth inhibition assay
Cell proliferation; 

PubMed: 24203492     


(A) HCT-15 cells were cultured in indicated concentrations of entinostat for up to 72 h, and proliferation determined by MTT assay as indicated. (B) HCT-15, CCH-OS-D, COL and HOS cells were cultured in indicated concentrations of entinostat for 72 h, and viable cell number was determined using the Vi-cell assay and proliferation index calculated. (C) Freshly-isolated human NK cells were cultured in indicated concentrations of entinostat for up to 72 h, and viability was assessed by flow cytometry for 7-AAD uptake. *, P < 0.05, **; P ≤ 0.01; ***, P ≤ 0.001

Cell viability; 

PubMed: 28969017     


PANC-1, MIA PaCa-2, BxPC3, CFPAC-1, SUIT2 and SUIT2 Clone 1 cells were plated at a density of 3-5×103 per well in 96-well microtiter plates, allowed to adhere overnight and incubated for 72 hours in the presence of variable concentrations of entinostat (0-100μM). Cell viability was determined by XTT assays. The data presented are the mean values from triplicate wells from two independent experiments ±SE.

24203492 28969017
ELISA