Tozasertib (VX-680, MK-0457)

For research use only. Not for use in humans.

目录号：S1048 中文名称：陶扎色替

Tozasertib (VX-680, MK-0457) Chemical Structure

CAS No. 639089-54-6

Tozasertib (VX-680, MK-0457)是一种pan-Aurora抑制剂，对Aurora A作用最强，无细胞试验中K_iapp为0.6 nM，而对Aurora B/Aurora C的作用较弱，对Aurora A选择性比其他55种激酶高100倍。唯二的例外是 Fms-related tyrosine kinase-3 (FLT-3) 和 BCR-ABL tyrosine kinase，也可被 Tozasertib 抑制，对应的Ki值均为30 nM和30 nM。Tozasertib 可诱导凋亡和自噬。Phase 2。

规格

价格

库存

购买数量

10mM (1mL in DMSO)	RMB 1098.34	现货
25mg	RMB 1211.51	现货
100mg	RMB 3017.92	现货
250mg	RMB 3833.09	现货
300mg	RMB 4316.13	现货
大包装	有超大折扣

大剂量询单有大折扣!

今日订购，明日送达，全国免运费！

全国免费电话：400-668-6834 | Email：info@selleck.cn

客户使用Selleck生产的Tozasertib (VX-680, MK-0457)发表文献102篇：

Nature, 2018, 559(7713):211-216.

PubMed: 29973724 ( click the link to review the publication )

Cancer Cell, 2014, 26(3):414-427

PubMed: 25175806 ( click the link to review the publication )

Cell Stem Cell, 2012, 11(2):179-94

PubMed: 22862944 ( click the link to review the publication )

Cell, 2010, 6;142(3):444-55.

PubMed: 20691903 ( click the link to review the publication )

J Cell Biol, 2021, 220(2)e202008029

PubMed: 33355621 ( click the link to review the publication )

PLoS Biol, 2021, 19(1):e3001029

PubMed: 33395410 ( click the link to review the publication )

Breast Cancer, 2021, 10.1007/s12282-021-01242-z

PubMed: 33813687 ( click the link to review the publication )

STAR Protoc, 2021, 2(3):100495

PubMed: 34195669 ( click the link to review the publication )

J Clin Invest, 2020, 139080

PubMed: 33016928 ( click the link to review the publication )

EMBO Rep, 2020, 3;21(4):e49700

PubMed: 32030856 ( click the link to review the publication )

Cancer Res, 2020, 80(18):3841-3854

PubMed: 32690724 ( click the link to review the publication )

Cancers (Basel), 2020, 12(11)E3172

PubMed: 33126775 ( click the link to review the publication )

Cancers (Basel), 2020, 12(9)E2697

PubMed: 32967224 ( click the link to review the publication )

Mol Cancer Ther, 2020, 10.1158/1535-7163.MCT-19-1017

PubMed: 32847978 ( click the link to review the publication )

Mol Cancer Ther, 2020, 19(4):1008-1017

PubMed: 31848297 ( click the link to review the publication )

Sci Adv, 2020, 6(29):eaba1941

PubMed: 32832623 ( click the link to review the publication )

Toxicol Sci, 2020, kfaa103

PubMed: 32617558 ( click the link to review the publication )

Cancer Res, 2019, 79(1):209-219

PubMed: 30389701 ( click the link to review the publication )

Cell Death Differ, 2019, 26(3):548-564

PubMed: 30050055 ( click the link to review the publication )

Cancers (Basel), 2019, 11(10)

PubMed: 31652588 ( click the link to review the publication )

Cell Death Dis, 2019, 10(6):385

PubMed: 31097686 ( click the link to review the publication )

Cell Death Dis, 2019, 10(6):432

PubMed: 31160567 ( click the link to review the publication )

Cell Chem Biol, 2019, 26(3):390-399.e5

PubMed: 30612951 ( click the link to review the publication )

FEBS J, 2019, 286(5):963-974

PubMed: 30600590 ( click the link to review the publication )
Antiviral Res, 2019, 170:104572

PubMed: 31376425 ( click the link to review the publication )

Toxicol Sci, 2019, 10.1093/toxsci/kfz123

PubMed: 31132080 ( click the link to review the publication )

Sci Rep, 2019, 9(1):1897

PubMed: 30760778 ( click the link to review the publication )

Analyst, 2019, 145(1):97-106

PubMed: 31746831 ( click the link to review the publication )

J Pharm Biomed Anal, 2019, doi: 101016/jjpba2019112962

PubMed: 31711864 ( click the link to review the publication )

Environ Mol Mutagen, 2019, 60(6):513-533

PubMed: 30702769 ( click the link to review the publication )

J Pediatr Hematol Oncol, 2019, 41(6):e359-e370

PubMed: 30702467 ( click the link to review the publication )

Int J Mol Sci, 2018, 19(12)

PubMed: 30544932 ( click the link to review the publication )

Cell Signal, 2018, 52:137-146

PubMed: 30223016 ( click the link to review the publication )

SLAS Discov, 2018, 23(2):132-143

PubMed: 28957641 ( click the link to review the publication )

Anticancer Drugs, 2018, 29(10):1004-1010

PubMed: 30080692 ( click the link to review the publication )

Oncotarget, 2018,

PubMed: 29560108 ( click the link to review the publication )

Neuron, 2017, 94(6):1142-1154

PubMed: 28641113 ( click the link to review the publication )

Nat Commun, 2017, 1;8(1):1232

PubMed: 29089541 ( click the link to review the publication )

Cancer Res, 2017, 77(2):494-508

PubMed: 28069801 ( click the link to review the publication )

Oncogene, 2017, 36(44):6177-6189

PubMed: 28869606 ( click the link to review the publication )

Oncogenesis, 2017, 6(2):e298

PubMed: 28218735 ( click the link to review the publication )

Toxicol Sci, 2017, 162(1):146-166

PubMed: 29106658 ( click the link to review the publication )

J Biol Chem, 2017, 292(36):15028-15038

PubMed: 28739871 ( click the link to review the publication )

Cell Signal, 2017, 39:74-83

PubMed: 28780319 ( click the link to review the publication )

Nat Chem Biol, 2016, 10.1038/nchembio.2017

PubMed: 26829474 ( click the link to review the publication )

Nat Commun, 2016, 7:10180

PubMed: 26782714 ( click the link to review the publication )

EMBO J, 2016, 35(8):803-19

PubMed: 26929011 ( click the link to review the publication )

Proc Natl Acad Sci U S A, 2016, 113(50):14366-14371

PubMed: 28182563 ( click the link to review the publication )
Elife, 2016, 5:e11402

PubMed: 26878753 ( click the link to review the publication )

Arch Toxicol, 2016, 291(10):4939-54

PubMed: 26404763 ( click the link to review the publication )

J Biol Chem, 2016, 10.1074/jbc.M116.722751

PubMed: 27226586 ( click the link to review the publication )

Cancer Biol Ther, 2016, 17(5):566-76

PubMed: 27082306 ( click the link to review the publication )

Exp Cell Res, 2016, 344(2):153-66

PubMed: 27138904 ( click the link to review the publication )

Cell Cycle, 2016, 15(15):2009-18

PubMed: 27249336 ( click the link to review the publication )

Oncol Rep, 2016, 36(2):819-26

PubMed: 27373675 ( click the link to review the publication )

Biochem Biophys Res Commun, 2016, 473(1):212-8

PubMed: 27003257 ( click the link to review the publication )

Exp Hematol, 2016, 44(3):189-93

PubMed: 26706195 ( click the link to review the publication )

Tumour Biol, 2016, 37(11):14745-14755

PubMed: 27629142 ( click the link to review the publication )

Oncotarget, 2016, 7(18):26580-92

PubMed: 27058891 ( click the link to review the publication )

Nat Cell Biol, 2015, 17(1):31-43

PubMed: 25503564 ( click the link to review the publication )

Nat Commun, 2015, 6:7935

PubMed: 26228240 ( click the link to review the publication )

Clin Cancer Res, 2015, 21(23):5338-48

PubMed: 26152738 ( click the link to review the publication )

Proc Natl Acad Sci U S A, 2015, 112(19):5875-82

PubMed: 25883264 ( click the link to review the publication )

Mol Cancer Ther, 2015, 14(2):419-28

PubMed: 25522764 ( click the link to review the publication )

Oncol Rep, 2015, 34(2):803-10

PubMed: 26044736 ( click the link to review the publication )

PLoS One, 2015, 10(7):e0134306

PubMed: 26218638 ( click the link to review the publication )

BMC Res Notes, 2015, 8:484

PubMed: 26415506 ( click the link to review the publication )

Mol Cancer Ther, 2015, 14(6):1354-64

PubMed: 25873592 ( click the link to review the publication )

J Mol Cell Biol, 2014, 6(3):240-54

PubMed: 24847103 ( click the link to review the publication )

Biochim Biophys Acta, 2014, 1843(5):934-44

PubMed: 24480460 ( click the link to review the publication )

Hum Gene Ther, 2014, 25(7):599-608

PubMed: 24568341 ( click the link to review the publication )

Am J Physiol Lung Cell Mol Physiol, 2014, 307(2):L173-85

PubMed: 24838752 ( click the link to review the publication )
Cell Cycle, 2014, 13(12):1885-901

PubMed: 24739512 ( click the link to review the publication )

PLoS One, 2014, 9(9):e108758

PubMed: 25268132 ( click the link to review the publication )

PLoS One, 2014, 9(7):e102741

PubMed: 25048812 ( click the link to review the publication )

Oncol Lett, 2014, 7(1):121-124

PubMed: 24348832 ( click the link to review the publication )

Oncotarget, 2014, 5(17):7498-511

PubMed: 25115395 ( click the link to review the publication )

Cancer Res, 2013, 73(22):6722-33

PubMed: 24101154 ( click the link to review the publication )

Cancer Res, 2013, 73(20):6310-22

PubMed: 24067506 ( click the link to review the publication )

Arthritis Rheum, 2013,

PubMed: 23653330 ( click the link to review the publication )

Mol Cancer Res, 2013, 12(3):433-9

PubMed: 24336958 ( click the link to review the publication )

Mol Cancer Res, 2013, 11(11):1326-36

PubMed: 24008673 ( click the link to review the publication )

J Cell Sci, 2013, 126(Pt 5):1235-46

PubMed: 23321637 ( click the link to review the publication )

J Cell Mol Med, 2013, 17(2):265-76

PubMed: 23301855 ( click the link to review the publication )

Vet Comp Oncol, 2013, 10.1111/vco.12018

PubMed: 23410058 ( click the link to review the publication )

Oncotarget, 2013,

PubMed: 23328114 ( click the link to review the publication )

Eur J Cancer, 2012, 48(15):2417-30

PubMed: 22244830 ( click the link to review the publication )

Oncogene, 2012, 31(31):3584-96

PubMed: 22120720 ( click the link to review the publication )

J Med Chem, 2012, 55(17):7392-416

PubMed: 22803810 ( click the link to review the publication )

Brain Pathol, 2012, 23(3):244-53

PubMed: 22971244 ( click the link to review the publication )

J Neurosci, 2012, 32(32):11050-66

PubMed: 22875938 ( click the link to review the publication )

Biochem Pharmacol, 2012, 83(9):1217-28

PubMed: 22306067 ( click the link to review the publication )

Biochem J, 2012, 447(1):93-102

PubMed: 22784093 ( click the link to review the publication )

Exp Cell Res, 2012, 318(4):336-49

PubMed: 22197704 ( click the link to review the publication )

Cytoskeleton, 2012, 69(10):840-53

PubMed: 22887753 ( click the link to review the publication )

J Biomol Screen, 2012, 18(4):388-99

PubMed: 23134735 ( click the link to review the publication )
Pediatr Surg Int, 2012, 28(6):579-89

PubMed: 22526548 ( click the link to review the publication )

Curr Biol, 2011, 21(16):1356-65

PubMed: 21820309 ( click the link to review the publication )

Cancer Res, 2011, 71(23):7207-15

PubMed: 21978935 ( click the link to review the publication )

J Biol Chem, 2011, 286(42):36304-15

PubMed: 21878642 ( click the link to review the publication )

Biochem J, 2011, 440(1):85-93

PubMed: 21774789 ( click the link to review the publication )

Mol Cancer Ther, 2010, 9(5):1318-27

PubMed: 20388735 ( click the link to review the publication )

产品安全说明书

Aurora Kinase抑制剂选择性比较

生物活性

产品描述

靶点

Aurora A ^[1] (Cell-free assay)	Aurora C ^[1] (Cell-free assay)	Aurora B ^[1] (Cell-free assay)	FLT3 ^[4] (Cell-free assay)	Bcr-Abl ^[4] (Cell-free assay)
0.6 nM(Ki app)	4.6 nM(Ki app)	18 nM(Ki app)	30 nM(Ki)	30 nM(Ki)

体外研究

虽然VX-680具有多激酶特性，VX-680却诱导相似的细胞毒性，IC50约为300 nM，在G2/M期，核内复制期，及转染ABL或FLT-3激酶的BaF3细胞凋亡时，显示一个Aurora B 类似的抑制表现型。VX-680抑制CAL-62细胞增殖，这种作用存在时间依赖性。用VX-680处理14天，明显降低群体的数量和大小，处理8305C下降达到70%，处理CAL-62, 8505C,和BHT-101下降达到90%。用VX-680处理不同ATC细胞，抑制细胞增殖，IC50为25到150 nM，这种作用存在时间和剂量依赖性。在软琼脂中，VX-680明显削弱不同细胞系形成群落的能力。caspase-3的活性分析显示VX-680诱导不同细胞凋亡。VX-680处理CAL-62 细胞12小时，形成DNA含量≥4N细胞累积物。微速摄影分析显示VX-680处理的CAL-62细胞离开细胞中期。VX-680可以抑制组蛋白H3的磷酸化作用。^[2] VX-680作用于携带T315I突变的BCR-Abl的病人样本，具有明显抑制活性。^[3]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
BE-13	NYO2SZdRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M{C2PGlEPTB;MD6wNFM{QCEQvF2=	NGnDdG49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
RS4-11	NILtTGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NEn2eGNKSzVyPUCuNFA1ODRizszN	MkO1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
MFH-ino	M3rUTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M4DteGlEPTB;MD6wNFk6KM7:TR?=	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
NTERA-S-cl-D1	NEXiUG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MVvJR\|UxRTBwMEG0N\|Qh\|ryP	NV;meXVoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
697	NHj2[\|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NH:1foRKSzVyPUCuNFI1PzFizszN	NVXufmV2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
NALM-6	NILpXHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NV\xXGlZUUN3ME2wMlAzPTV{IN88US=>	NVvD[oc{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
ES8	MkjZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NWixbpBCUUN3ME2wMlA1PjF\|IN88US=>	MnXBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
HUTU-80	M2PxeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MkfKTWM2OD1yLkC1Nlk6KM7:TR?=	MkjWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
MV-4-11	NWPNUIRCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MVnJR\|UxRTBwMEe3PFIh\|ryP	Mn7OQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
MONO-MAC-6	NH3VfVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			Mom1TWM2OD1yLkC3PFc6KM7:TR?=	MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
LC-2-ad	NFf1T2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NGfYO49KSzVyPUCuNFg4QDlizszN	NIq0WGk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
BL-41	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			M{TOXmlEPTB;MD6xNFQ1PSEQvF2=	MlS5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
A4-Fuk	NWD4b4RQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MVjJR\|UxRTBwMUG1OlMh\|ryP	MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
SW954	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			M{PLfGlEPTB;MD6xNlIzQSEQvF2=	MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
BV-173	NEW1dotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MYjJR\|UxRTBwMUK2OFEh\|ryP	NIC1bG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
TE-11	NUD0U\|hET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M1v3XmlEPTB;MD6xOFk5OiEQvF2=	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
SK-UT-1	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MYnJR\|UxRTBwMUW5OlUh\|ryP	MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
SIG-M5	Mm\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			M1rGRmlEPTB;MD6xOlcxPyEQvF2=	M4j6WlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
OCUB-M	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NICzR\|FKSzVyPUCuNVY6QDNizszN	NX\ac\|loRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
K052	MmTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NWfyUWpmUUN3ME2wMlE6PDhizszN	NWXifIpHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
VA-ES-BJ	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NVO0TY9VUUN3ME2wMlIxODh4IN88US=>	NE\IWJk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
SW982	NGjscXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M2jSTmlEPTB;MD6yNVM5KM7:TR?=	NGjCOWo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
LB647-SCLC	NGjZcZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			Mo\oTWM2OD1yLkKxOVI{KM7:TR?=	NFG3T3o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
PSN1	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NFi0UndKSzVyPUCuNlIxOjZizszN	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
BB30-HNC	M3;h[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M3HvW2lEPTB;MD6yNlU6OSEQvF2=	NF3Tc2k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
ST486	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MlvwTWM2OD1yLkKzNFg4KM7:TR?=	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
MOLT-4	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NIKzbZVKSzVyPUCuNlM{OzdizszN	MnGxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
EW-16	NWP5VZRPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			Mlq5TWM2OD1yLkKzO\|Y5KM7:TR?=	MmfHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
KS-1	NHHzVmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NHTKfFlKSzVyPUCuNlM4QDVizszN	NHriSlE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
SR	Mn\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MkjjTWM2OD1yLkK0OVY1KM7:TR?=	MoPVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
KM12	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NWm4ZVhVUUN3ME2wMlI3OzZizszN	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
EM-2	NXXOblBYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NVO2dZJsUUN3ME2wMlI3PjRzIN88US=>	M{jWdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
MEG-01	Ml75S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NVG3fHpHUUN3ME2wMlI4QDR7IN88US=>	NX;hSJpbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
NB13	M1LjOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M1;hPGlEPTB;MD6yO\|k5PCEQvF2=	NXjEWndLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
RKO	M1nZV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NVK4ZmQ5UUN3ME2wMlMxQDF\|IN88US=>	M3v3b\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
CESS	NHHJZ49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M{n1ZmlEPTB;MD6zNVMzQCEQvF2=	NIHZbFM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
EoL-1-cell	NY\ReoU1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MkSyTWM2OD1yLkOzOFU6KM7:TR?=	NEXXTmE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
DOHH-2	NH7iZopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NH62OnNKSzVyPUCuN\|M4QDFizszN	NF75W2E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
A388	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			M3rwPGlEPTB;MD6zOFA5PiEQvF2=	M33DTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
LAMA-84	M37xVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NYTnZY5PUUN3ME2wMlM2OTd6IN88US=>	M37aZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
IMR-5	Mni4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MWLJR\|UxRTBwM{W1OEDPxE1?	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
KARPAS-422	MkPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MWjJR\|UxRTBwM{eyO\|Ih\|ryP	NVLRN5Y1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
MRK-nu-1	M1uxVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MVjJR\|UxRTBwM{ixN{DPxE1?	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
BL-70	NW\HfJhoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MWXJR\|UxRTBwM{i5O\|Qh\|ryP	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
LXF-289	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MVXJR\|UxRTBwNEC0NFYh\|ryP	NYX0bXZ3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
RL95-2	NHrQfVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MXTJR\|UxRTBwNEC1Olch\|ryP	NWjuWVlnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
QIMR-WIL	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MknRTWM2OD1yLkSyOlc3KM7:TR?=	NEPpS2w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
K-562	NXruN3ViT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NEnXc5hKSzVyPUCuOFM1PzJizszN	M4TWVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
NCI-H510A	MkfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MWTJR\|UxRTBwNEO4NlMh\|ryP	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
NCI-H524	NXXBd4hUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MX3JR\|UxRTBwNUGxOFch\|ryP	NGm5NmY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
KE-37	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			M3i2cWlEPTB;MD61NlExOiEQvF2=	NGPPZY89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
KP-N-YS	M4\RbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NEP4b2pKSzVyPUCuOVQ{QTJizszN	Mn7BQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
LS-411N	NHj5b25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NXH2WWFWUUN3ME2wMlU4PzV{IN88US=>	MlrvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
CTV-1	M3r2WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NYrVTnFzUUN3ME2wMlU5Pzd\|IN88US=>	M3\ZfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
NCI-SNU-16	NUnCdHBsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NEPtNmhKSzVyPUCuOlM2PzFizszN	M17NdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
HT-144	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MXvJR\|UxRTBwNkO3PVgh\|ryP	NV3F[WRPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
NCI-H187	M1\n[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MYjJR\|UxRTBwNkSxN{DPxE1?	Mo\PQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
OCI-AML2	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MXnJR\|UxRTBwNkS0NFMh\|ryP	M2\LUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
CCRF-CEM	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MXjJR\|UxRTBwNkWzOFYh\|ryP	MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
ONS-76	M1TnPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MmL4TWM2OD1yLk[2OFU5KM7:TR?=	MoPEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
IST-SL2	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NUTSWphIUUN3ME2wMlcyQTh{IN88US=>	Mo\qQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
NB6	MkT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NEHo[mpKSzVyPUCuO\|czPTRizszN	Mmm1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
SK-PN-DW	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NWLSeIF6UUN3ME2wMlc6OTRizszN	Mlf6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
HCC1599	M3;CZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			Ml7LTWM2OD1yLkiwPFc1KM7:TR?=	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
MC116	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MmPPTWM2OD1yLki1NFEyKM7:TR?=	M{f2T\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
TE-15	NEHzbJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NUDEPJFXUUN3ME2wMlg2ODl6IN88US=>	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
HOP-62	NWX6NFJOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MY\JR\|UxRTBwOE[zNlkh\|ryP	M2qyT\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
TGBC24TKB	NWTGe4p7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NWTGd3ZJUUN3ME2wMlg3Ozh3IN88US=>	M2rjeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
HCE-4	MlvyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MXzJR\|UxRTBwOEiwOlMh\|ryP	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
ALL-PO	Mn;MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MV\JR\|UxRTBwOEixO\|Uh\|ryP	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
KGN	NGPpWIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NUDMN3ExUUN3ME2wMlg6QTl3IN88US=>	MmTWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
ML-2	NIP6bZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MorCTWM2OD1yLkmwNlU6KM7:TR?=	NYH2NIp{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
ES4	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			M2P0SmlEPTB;MD65NVEzQCEQvF2=	M4TNNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
SF126	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MXzJR\|UxRTBwOUS4NVkh\|ryP	NE\PUJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
SK-N-DZ	NYDJfIx1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NYm4WJlYUUN3ME2wMlk3OTh7IN88US=>	MlnVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
HCC1187	NUHKd\|BjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MojtTWM2OD1zLkCwOVA2KM7:TR?=	NF:yNJQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
DU-4475	NGf4V3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NEe4bIVKSzVyPUGuNFE4PTZizszN	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
NKM-1	NYLn[41HT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MWDJR\|UxRTFwMEK3O\|Uh\|ryP	M4K4VVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
HL-60	NETpdHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MkHtTWM2OD1zLkC2OVc1KM7:TR?=	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
SBC-1	MlXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MnrqTWM2OD1zLkGyOVQzKM7:TR?=	MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
TE-10	M3Py[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M1jod2lEPTB;MT6xNlk1PiEQvF2=	NWPqUpI4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
ETK-1	M{fOWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NW\RW5E{UUN3ME2xMlE{PjF\|IN88US=>	NU\CSGRpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
HAL-01	MkThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NInD[WpKSzVyPUGuNVY4ODlizszN	MkDKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
BB65-RCC	MknTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			M4HEVGlEPTB;MT6xPFAxPSEQvF2=	NWO0PINYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
EW-1	NYXzNIRKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M1TlXWlEPTB;MT6xPFU3OiEQvF2=	NGLJZVk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
SK-NEP-1	NFnFO5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MoiwTWM2OD1zLkKxNVEyKM7:TR?=	M{f5dlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
SK-LMS-1	NGnsTJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NE\GSYpKSzVyPUGuNlIzOTJizszN	MknvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
DEL	NYTC[WtzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MYTJR\|UxRTFwMkW2OFMh\|ryP	NFvYXFA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
GT3TKB	M1jDTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MYLJR\|UxRTFwMkiwOVch\|ryP	NVm3cpU{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
MOLT-16	M4DaZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NV:2TVdPUUN3ME2xMlM2PDB3IN88US=>	Mo\3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
CMK	MnP5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			M1rBbWlEPTB;MT60NlEyPyEQvF2=	NV3w[5dNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
NB5	NWf5dldNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NHX0eIVKSzVyPUGuOlQzOjlizszN	Mk\1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
NCI-H1963	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MmXrTWM2OD1zLkewOVg{KM7:TR?=	MnWxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
KURAMOCHI	NV3FXFNPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NXS3RnZLUUN3ME2xMlc5QTFzIN88US=>	NHrGRmU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
TE-8	NVX1NlEyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NG\E[FdKSzVyPUGuPFA{PjhizszN	NHTtdlU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
NCI-H1304	MnP5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NVfqZYlxUUN3ME2xMlg{ODd\|IN88US=>	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
A101D	NGnob3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MXXJR\|UxRTFwOEezPVUh\|ryP	M1v0VlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
SCLC-21H	M373emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M1jteGlEPTB;MT65O\|A2PyEQvF2=	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
GB-1	Mn2wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			M2fM[GlEPTB;Mj6wNVY1PyEQvF2=	NWO3VnZQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
KARPAS-45	M2CyTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NHP3NXpKSzVyPUKuNFI3PTRizszN	M3zUblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
ATN-1	NGP1cXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NF[yUFNKSzVyPUKuNFI5PThizszN	MmTlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
NCI-H720	MkfiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			M4T0SWlEPTB;Mj6wOlI1PCEQvF2=	MnHlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
RPMI-6666	NY[5cmp1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NFHrOHRKSzVyPUKuNVYzODdizszN	MonzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
NB17	M1zJZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M4XCWGlEPTB;Mj6yPVI4KM7:TR?=	NHm0bGQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
IST-SL1	Moq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NGXwXmRKSzVyPUKuNlk4PjVizszN	M2GyblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
SH-4	Ml21S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			Mnq4TWM2OD1{LkOyOFY6KM7:TR?=	M{HCUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
K5	NVf0XVQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MnS1TWM2OD1{LkSwN\|E6KM7:TR?=	MnrHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
OVCAR-4	NYrGV5k2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M4[3RWlEPTB;Mj60OlE{KM7:TR?=	NEPDWJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
ACN	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NWDpRZdXUUN3ME2yMlUxOjF\|IN88US=>	NX7wXmtsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
TGW	NUTZNFBUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M4TLbGlEPTB;Mj62OVg{OiEQvF2=	M3T0PFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
NCI-H2107	MoHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MWTJR\|UxRTJwOEO3NVEh\|ryP	NIrydJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
NCI-H82	MlPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NXL1RZpGUUN3ME2yMlg{QDN6IN88US=>	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
SK-N-FI	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			M3r6UmlEPTB;Mj64Olg3QCEQvF2=	NUjKSm5WRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
LB1047-RCC	NVPHTGY3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MnLVTWM2OD1{Lki4NVI3KM7:TR?=	MoCyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
LU-134-A	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MmrpTWM2OD1{Lki5NlYh\|ryP	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
NCI-H209	NVz3c2wzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M3PDSmlEPTB;Mj65NVI2OyEQvF2=	M13NcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
NOMO-1	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MYjJR\|UxRTNwMEKyO\|Qh\|ryP	MkHzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
RH-1	NH[wcmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			Mn60TWM2OD1\|LkG3NlkyKM7:TR?=	NFv5S\|Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
LOUCY	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NUPNc4V[UUN3ME2zMlE5Pjl\|IN88US=>	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
TE-9	M{LNO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MmXqTWM2OD1\|LkK2O\|M3KM7:TR?=	NWnkVmw4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
PF-382	NGqx[mRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NIK2eZhKSzVyPUOuN\|U4PzhizszN	M2nwcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
RPMI-8402	NEXyW3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NWXLOmRkUUN3ME2zMlU5PjB\|IN88US=>	MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
HEL	NF;SW3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			Mnj6TWM2OD1\|Lk[zNkDPxE1?	M2HyWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
NOS-1	M1;hUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NX;0V3hvUUN3ME2zMlg1PzV2IN88US=>	MnqyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
ES1	NI[y[mlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MWTJR\|UxRTNwOUKyPVMh\|ryP	NIC5fZI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
NCI-H2171	M2HKcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MYLJR\|UxRTNwOUK0NlMh\|ryP	NFjudGo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
NCI-H747	M4OwZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MWLJR\|UxRTNwOUSyNlEh\|ryP	NV7udIRbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
MHH-NB-11	Mnn0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			M{[4dWlEPTB;Mz65OVMyOiEQvF2=	MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
MZ1-PC	NIDBVoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M1qzN2lEPTB;Mz65PVI1KM7:TR?=	Mly2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
MMAC-SF	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NXTOPZEzUUN3ME20MlAzPDZ5IN88US=>	M2jGPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
NMC-G1	NFTnbFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M4jvcGlEPTB;ND6yNlczOyEQvF2=	NH;FWlM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
SW872	NEHYPY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MnfSTWM2OD12LkO0N\|Qh\|ryP	NVn6cHNoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
TE-12	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NGKxcGFKSzVyPUSuOVY{QTRizszN	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
LU-139	NFXjcVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MX\JR\|UxRTRwNkG4N\|Uh\|ryP	M3vNN\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
HC-1	NHPMPWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NUThbmpVUUN3ME20MlY6PDl2IN88US=>	NYnZN3V5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
COR-L279	NGSxWFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NETOSIdKSzVyPUSuO\|U5QTFizszN	MnixQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
SF268	M3vLPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M3PEV2lEPTB;ND63PVkyPiEQvF2=	NX\ad2VvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
MC-CAR	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NEXkW5FKSzVyPUWuNFY4PTdizszN	M1zYVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
TK10	MlLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NHLOW4VKSzVyPUWuN\|U1PjlizszN	NVnwSpB3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
TE-1	NHXreHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MVPJR\|UxRTVwNEmwNFQh\|ryP	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
NCI-H2126	NXGzZ5JFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NYTjT4RYUUN3ME21MlY1PTd2IN88US=>	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
Daudi	MmDJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MUHJR\|UxRTVwNkmxNkDPxE1?	M4H5T\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
NCI-H1648	NXP5RlFZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MlnqTWM2OD13LkixOFU1KM7:TR?=	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
OS-RC-2	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MlnHTWM2OD13Lkm4OVk4KM7:TR?=	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
DJM-1	M2DrXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			Ml\CTWM2OD14LkO0OlY3KM7:TR?=	M1fnNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
LS-1034	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MojaTWM2OD14Lke1OlYh\|ryP	NWrV[oQ3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
NCI-H1581	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MkTuTWM2OD14Lke4OFA2KM7:TR?=	Mli2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
UACC-257	NWnaXXk5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M3LJOmlEPTB;Nz6wOFUyOiEQvF2=	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
KM-H2	M2DvWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MXvJR\|UxRTdwMUi0OVch\|ryP	M1T2R\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
NCI-H1436	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NFj6T3ZKSzVyPUeuOlk6OzJizszN	NFOzUZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
IA-LM	NGrXbIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NI[0[GNKSzVyPUeuPFU6KM7:TR?=	M{joOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
NCI-H526	MmLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NV7XVnJHUUN3ME24MlI2PjN5IN88US=>	NUDRbFVrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
GCIY	NUHGcI54T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MYPJR\|UxRThwM{[5OlUh\|ryP	MmP1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
CP67-MEL	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NV32WIU2UUN3ME24MlU{OjZizszN	NInzTHc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
KALS-1	MlTVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MYPJR\|UxRThwOEO4OVEh\|ryP	MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
NCI-H1770	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MkHDTWM2OD16LkmwNlY2KM7:TR?=	MoriQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
8-MG-BA	Mof6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			M{D4R2lEPTB;OT6zNlg1PCEQvF2=	NGT3fJc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
KY821	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NWjtbnVWUUN3ME25Mlc4PDh2IN88US=>	NUfvToJRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
SNB75	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			Ml7iTWM2OD1zMD6wO\|Yh\|ryP	M1n1PFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
NCCIT	NInYUIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NHe3SoRKSzVyPUGxMlA2QDJizszN	NXzsbIdJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
SJSA-1	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NGX6dnZKSzVyPUGxMlI5QTFizszN	NYK4SJR{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
LB373-MEL-D	NY\oUnFzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NUjn[lZCUUN3ME2xNU4{QDJ5IN88US=>	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
TALL-1	NFzy[\|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NIXEXY5KSzVyPUGxMlQxPThizszN	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
NB69	NU\zdXlOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M3nFbGlEPTB;MUGuO\|cxPSEQvF2=	NH3wcVc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
NCI-H1355	Mkm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			M3HCT2lEPTB;MUGuPVQzPiEQvF2=	M{X4dlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
DMS-153	NV3pb5d1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MWjJR\|UxRTF{LkC0NlYh\|ryP	NYjRVldlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
OPM-2	NFfFVmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NYHHZ2VXUUN3ME2xNk4yPTl4IN88US=>	M4LkWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
NB1	Mnz5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MnjaTWM2OD1zMj6yPUDPxE1?	NFLyT5Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
A3-KAW	NFLse\|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			Ml;4TWM2OD1zMj6zNlM3KM7:TR?=	MoHwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
NCI-H1882	NYHnXpZjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NXjnWpRrUUN3ME2xNk41ODZ4IN88US=>	NG\0do09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
KG-1	NUK1clE3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NV\vWm0{UUN3ME2xNk43PTR3IN88US=>	M2rKVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
LC4-1	M1fVZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7			Mnq3TWM2OD1zMj63O\|A3KM7:TR?=	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
HCE-T	NIDrOmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			Ml7OTWM2OD1zMz6wNFQ6KM7:TR?=	NIP1dHQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
NEC8	MnP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MlPnTWM2OD1zMz6xNFM5KM7:TR?=	NEjmSYI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
IST-MEL1	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MkDKTWM2OD1zMz61O\|g5KM7:TR?=	M2XVZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
EW-3	M{PzbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M4PXe2lEPTB;MUOuO\|QxOiEQvF2=	NFLkRW09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
CTB-1	NEPWSYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MlHBTWM2OD1zND6wN\|I6KM7:TR?=	Moj0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
LS-123	NX;BSpVwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MX7JR\|UxRTF2LkG1PFgh\|ryP	NHW1b2w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
NCI-H1417	NYP0fYZHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MUjJR\|UxRTF2LkOwOVIh\|ryP	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
MZ7-mel	M2TNWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NY\JO4JoUUN3ME2xOE41PDN\|IN88US=>	M{DWN\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
JiyoyeP-2003	NEXuXJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NYPab5pYUUN3ME2xOU43OzJ4IN88US=>	MlX6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
ES6	NWPLOXZjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MXzJR\|UxRTF4LkKzOlEh\|ryP	MnvTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
HH	M2LKUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NIjGWJNKSzVyPUG3MlE6PjNizszN	MmG5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
SF539	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NFTWS25KSzVyPUG3Mlk6OjJizszN	MoraQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
Calu-6	NYXrOG1FT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NYDkboFNUUN3ME2xPU4zOzlizszN	MmHoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
SK-MM-2	NF6yfpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MknETWM2OD1zOT61OVUh\|ryP	NVXrNIVxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
IST-MES1	NYCzb21nT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			Mnn5TWM2OD1zOT62OlY{KM7:TR?=	NWHjNJBFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
GI-ME-N	MnjyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			M4jFdWlEPTB;MUmuPFIzPyEQvF2=	NX;nO3VzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
CAL-148	M{XOdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M1nOOWlEPTB;MkCuPVk{PCEQvF2=	NEPT[Gg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
EVSA-T	NHvxe\|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M2\FeGlEPTB;MkGuNVQ6QSEQvF2=	MnTlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
LP-1	M1S1N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M4nwe2lEPTB;MkGuN\|Q{OiEQvF2=	MlLZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
BOKU	MmXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MWjJR\|UxRTJzLkS1N\|Mh\|ryP	NH;O[JU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
KLE	NInVNY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M2XtUmlEPTB;MkKuNVkxOyEQvF2=	NVvTOJpjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
LB831-BLC	MkHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NHXFbZBKSzVyPUK1MlE2OjZizszN	MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
NCI-H889	M1rJV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M2r0dGlEPTB;MkWuNVk{OSEQvF2=	NF;tfGQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
REH	NFK5[4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M2rMOmlEPTB;MkWuOFY4OSEQvF2=	NU\iVGppRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
KP-N-RT-BM-1	NYm4OXUzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NG\1O3JKSzVyPUK1MlQ4PTJizszN	NVm0N5FNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
MPP-89	NWKyO3R6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NGfrfZRKSzVyPUK1MlU{OTRizszN	NYOzfnZNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
no-11	MmnCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			M2j3XmlEPTB;MkWuO\|Q4KM7:TR?=	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
NCI-H748	NGrNepNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NID4UmFKSzVyPUK1Mlc3OjdizszN	MnPOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
LB2518-MEL	NUTLRXBZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NGTKSpBKSzVyPUK3MlE4PzNizszN	NFHBSYQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
TGBC1TKB	M37QS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M2C0WmlEPTB;MkeuOVU5PSEQvF2=	NG\mPYM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
MHH-PREB-1	M{e3SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MmXuTWM2OD1{OD6wO\|M1KM7:TR?=	Mlm2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
MZ2-MEL	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MWTJR\|UxRTJ6Lk[xOFMh\|ryP	NFXXXow9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
U-266	NI\vTW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MnvpTWM2OD1{OD62N\|Y3KM7:TR?=	NIro[YQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
SNU-C1	M{H2Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NVzaS5JIUUN3ME2yPE46PDNizszN	NVzKfnJmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
SW962	MoC2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NWC4boJ2UUN3ME2zNE4zPzR5IN88US=>	NHL4dVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
Raji	NXnoPYlRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NIKyZnFKSzVyPUOwMlU2QTJizszN	Mm\aQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
KNS-42	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MVjJR\|UxRTNyLki5OVYh\|ryP	NWTnOGs5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
LB996-RCC	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MofQTWM2OD1\|MT6xO\|AzKM7:TR?=	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
CHP-126	NFrXXYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NYXkWI5oUUN3ME2zNU4yQTh2IN88US=>	NFmwcYc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
RXF393	MnrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NIXjR\|RKSzVyPUOyMlQ6PyEQvF2=	NIjrcmU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
COLO-684	NWTWbJp5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MXfJR\|UxRTN{Lk[0N\|gh\|ryP	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
A704	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MorQTWM2OD1\|Mz61OVM5KM7:TR?=	NWLO[3hRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
A253	MnT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MnuyTWM2OD1\|Mz61PFUzKM7:TR?=	NXHNNWZPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
KNS-81-FD	Mn\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			M3;XSGlEPTB;M{SuOVQ2PiEQvF2=	MoXtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
TE-441-T	M4LHO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M2PYcmlEPTB;M{SuOlM4OSEQvF2=	M2Li[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
HCC2157	NGLTdFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M4D1XGlEPTB;M{WuOFYyQSEQvF2=	M{Lzc\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
ES3	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NYnLNpZ[UUN3ME2zOk43PzVizszN	NUXydXNQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
NCI-H1155	NFjrNodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M1zzWmlEPTB;M{euPFE2KM7:TR?=	NFrD[nk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
SNU-C2B	MlPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NFPZb\|hKSzVyPUO4MlE3PTRizszN	Mn7iQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
JAR	Ml;oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NGG3VYVKSzVyPUO4MlI1PDlizszN	MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
GDM-1	M{P4WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NInQcY1KSzVyPUO4MlkyOTZizszN	NWDWeZNlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
KU812	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NWq2c45wUUN3ME20NU42ODdizszN	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
BC-1	Mlr3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NHLHe2lKSzVyPUSyMlY4OzFizszN	NEf5c3g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
GI-1	NWfTcFBbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M4HWZ2lEPTB;NEKuPVE6OiEQvF2=	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
NCI-H1694	NEK3[FVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NW\LTo41UUN3ME20OE46PDd{IN88US=>	NXf1Rnh2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
DG-75	NIq2OGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MnXUTWM2OD12NT6xOVc4KM7:TR?=	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
COR-L88	M{jLVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MkT0TWM2OD12NT6yO\|c5KM7:TR?=	Mm\6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
LS-513	NEnibJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MUHJR\|UxRTR3LkmxOVYh\|ryP	M3;zcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
HD-MY-Z	MkDVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MWXJR\|UxRTR4LkS2NVIh\|ryP	NH7aXmw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
L-363	NUm1[VFOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M2f3T2lEPTB;NE[uPFgyKM7:TR?=	M1zndFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
TE-6	NW\BT4ZQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MmHLTWM2OD12OD60OFYh\|ryP	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
NCI-H345	NFrXNVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NYTRZmN[UUN3ME20PE41PjhizszN	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
TE-5	NF7GTZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MW\JR\|UxRTR7LkexNVgh\|ryP	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
MCF7	M2rE[mFvfGmycn;sbYZmemG2aY\lJIF{e2G7			MY\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNuIFnDOVA:OC5yNElOwG0>	NEn1cI09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOE[zNFg6OCd-MUi2N\|A5QTB:L3G+
HCT116	NYHLU3RXSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=			MUDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEGxOkBk\WyuczygTWM2OD1yLkC1N:69VQ>?	NYPvZpI3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi2N\|A5QTBpPkG4OlMxQDlyPD;hQi=>
HT29	NYn3dVI1SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=			NGjX[mtCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjUNlkh[2WubIOsJGlEPTB;MD6xOe69VQ>?	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDZ\|MEi5NEc,OTh4M{C4PVA9N2F-
HCT	M4PwN2Z2dmO2aX;uJIF{e2G7			M2e3XWlvcGmkaYTpc44hd2ZiQYXyc5JiKEFiaX6gbJVu[W5iSFPUJINmdGy\|IHHzd4V{e2WmIHHzJIxwe3Nib3[gZZV1d3Cqb4PwbI9zgWyjdHnvckBw\iCDdYLvdoEhSSxiSVO1NF0xNjNzzszN	MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDZ\|MEi5NEc,OTh4M{C4PVA9N2F-
HCT	Mn[xSpVv[3Srb36gZZN{[Xl?			NYn6dolSUW6qaXLpeIlwdiCxZjDBeZJwemFiQTDhd5Nme3OnZDDhd{B{\XCjcnH0bY9vKG:oIHPlcpRzd3OxbXXzJIlvKGi3bXHuJGhEXCClZXzsd{whUUN3ME2wMlMy\|ryP	MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDZ\|MEi5NEc,OTh4M{C4PVA9N2F-
HCT	M4T6S2Z2dmO2aX;uJIF{e2G7			NFjTSYxKdmirYnn0bY9vKG:oIFH1do9z[SCEIHHzd4V{e2WmIHHzJIxwe3Nib3[gdIhwe3CqbzDobZN1d26nIFizJIlvKGi3bXHuJGhEXCClZXzsd{whUUN3ME2wMlMy\|ryP	NUfhSIlWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi2N\|A5QTBpPkG4OlMxQDlyPD;hQi=>
H29	NIHsNlNHfW6ldHnvckBie3OjeR?=			Ml7YTY5pcWKrdHnvckBw\iCDdYLvdoEhSiCjc4Pld5Nm\CCjczDsc5N{KG:oIIDoc5NxcG9iaHnzeI9v\SCKMzDpckBpfW2jbjDINlkh[2WubIOsJGlEPTB;MD63OO69VQ>?	NIq3V4s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOE[zNFg6OCd-MUi2N\|A5QTB:L3G+
HCT116	M2DXN2N6fG:2b4jpZ4l1gSCjc4PhfS=>		MnzrNVAhfG9iMUSg[IF6ew>?	NH\4b5ZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJS1RzMU[gZ4VtdHNiYYPz[ZN{\WRiYYOgcpVu[mW{IH;mJINwdG:waXXzJIFnfGW{IEGwJJRwKDF2IHThfZMh[nliY3;sc456KG[xcn3pcoch[XO\|YYmsJGlEPTB;MD6wNlTPxE1?	NVLhNpBzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmxOFM2PjdpPkG5NVQ{PTZ5PD;hQi=>
HCT116	NE\0RW5EgXSxdH;4bYNqfHliYYPzZZk>		Ml7WO\|IhcHK\|	MnjaR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGNVOTF4IHPlcIx{KGG\|c3Xzd4VlKGG\|IHTpd5RqdmO2IIDvcJlxdG:rZImgdIhmdm:2eYDlJIFnfGW{IEeyJIhzeyxiQXP0bZZqfHl;MD6wN:69VQ>?	NVTNWIpERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmxOFM2PjdpPkG5NVQ{PTZ5PD;hQi=>
COLO205	M1LXXGFvfGmycn;sbYZmemG2aY\lJIF{e2G7			MnLQRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCFT1zPNlA2KGOnbHzzJIJ6KFt\|SG30bJlucWSrbnWgeZB1[WunIHHzd4F6NCCLQ{WwQVAvODF7zszN	MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTR2N{[yNkc,OTl2NEe2NlI9N2F-
HCT116	NI\SSYtEgXSxdH;4bYNqfHliYYPzZZk>			NGrOXYJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJS1RzMU[gZ4VtdHNiYomgUXRUKGG\|c3H5MEBKSzVyPUCuNVLPxE1?	M1;6c\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNUWwNlEzLz5{MEW1NFIyOjxxYU6=
HeLa	MWrGeY5kfGmxbjDhd5NigQ>?			NHS5VVJKdmirYnn0bY9vKG:oIIDoc5NxcG:2cnHud4ZmemG\|ZTDhZ5Rqfmm2eTDv[kBz\WOxbXLpcoFvfCCjdYLvdoEhSSCneIDy[ZN{\WRiaX6gTIVN[SClZXzsd{whU2l;MD6wNFLPxE1?	Mmi4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB3N{O1NFkoRjJyNUezOVA6RC:jPh?=
BA/F3	M2XWSGFvfGmycn;sbYZmemG2aY\lJIF{e2G7			MkWyRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDtc5V{\SCEQT;GN{Bk\WyuczDlfJBz\XO\|aX7nJGJkei2DYnygWFMyPUlibYX0ZY51NCCLQ{WwQVAvODQQvF2=	NWSwV2N{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC2NFQ2PjRpPkKwOlA1PTZ2PD;hQi=>
BA/F3	MVXGeY5kfGmxbjDhd5NigQ>?			MWfJcohq[mm2aX;uJI9nKEKlcj3BZowhXDNzNVmgcZV1[W62IHH1eI9xcG:\|cHjvdplt[XSrb36gbY4hdW:3c3WgRmEwTjNiY3XscJMtKEmFNUC9Oe69VQ>?	M4nGRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNkC0OVY1Lz5{ME[wOFU3PDxxYU6=
insect	MlT3SpVv[3Srb36gZZN{[Xl?			NGLlTFRKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjpd{11[WepZXSgRZVzd3KjIFGgb4lv[XOnIHX4dJJme3OnZDDpckBqdnOnY4SgZ4VtdHNuIFnDOVA:OC5yMEC3{txO	MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTF7NEm1N{c,OjFzOUS5OVM9N2F-
HCT116	M2frR2FvfGmycn;sbYZmemG2aY\lJIF{e2G7			NUm4fJJLSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMtKEmFNUC9NE4xOjkQvF2=	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOThyMkm0PEc,OjF6MEK5OFg9N2F-
HCT116	MlrNSpVv[3Srb36gZZN{[Xl?			M2fJdmlvcGmkaYTpc44hd2ZiQYXyc5JiKEJia3nuZZNmKGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDpckBpcXO2b37lJGg{KHCqb4PwbI9zgWyjdHnvckBqdiCqdX3hckBJS1RzMU[gZ4VtdHNuIFnDOVA:OC5yNUZOwG0>	M3rz[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOECyPVQ5Lz5{MUiwNlk1QDxxYU6=
HCT116	M2fCZmN6fG:2b4jpZ4l1gSCjc4PhfS=>		MUi0PEBpenN?	NI\TT3REgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJS1RzMU[gZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0xNjQQvF2=	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV5MkW4NEc,OjJ3N{K1PFA9N2F-
MCF7	MmrJR5l1d3SxeHnjbZR6KGG\|c3H5		M{DlOFQ5KGi{cx?=	NGfiUFREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUC9NE4{QM7:TR?=	NVfxUYpZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK1O\|I2QDBpPkKyOVczPThyPD;hQi=>
sf9	MkHhSpVv[3Srb36gZZN{[Xl?		M3v3WVE2KG2rboO=	NWfhb4w4UW6qaXLpeIlwdiCxZjDHV3QufGGpZ3XkJGF2em:{YTDrbY5ie2ViQTDjZZRidHm2aXOg[I9u[WmwIDixNlMhfG9iNECxJIFucW6xIHHjbYR{MSBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDz[lkh[2WubIOgeZNqdmdidHX0doEpVFKUV2PMS{kh[XNic4Xid5Rz[XSnIIDy[Ylv[3WkYYTl[EBnd3JiMUWgcYlveyCycnnvdkB1dyC\|dXLzeJJifGViYXTkbZRqd25ibXXhd5Vz\WRiYX\0[ZIhQTBibXnud{BjgSCudX3pcoV{[2WwY3WgZZN{[XluIFnDOVA:OC5yMt88US=>	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzhyOEOyO{c,OjN6MEizNlc9N2F-
HCT116	MXrBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NUXFO2M6QTZiaILz	Mn20RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCKQ2SxNVYh[2WubIOgZYZ1\XJiOU[gbJJ{KGK7IF3UV{Bie3OjeTygSWM2OD1yLkGy{txO	NGfncno9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{iwPFMzPyd-MkO4NFg{Ojd:L3G+
HCT116	MlG2RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?			M3rR[WFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFPUNVE3KGOnbHzzMEBKSzVyPUCuNVLPxE1?	NYrLZYpLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4NFg{OjdpPkKzPFA5OzJ5PD;hQi=>
HCT116	MlvNRY51cXS3bX;yJIF{e2G7	NIDPe3A2OCCvZz;r[y=>	MorPOUBl[Xm\|	MnHRRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFPUNVE3KGOnbHzzJJhmdm:pcnHmeIVlKGmwIHH0bJlucWNiboWvcpUhdW:3c3WgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIIT1cY9zKHOrenWgZZQhPTBibXevb4ctKGm4IIHkJIZweiB3IHThfZMheGW{IIfl[Ysh\m:{IEKge4Vmc3NibXXhd5Vz\WRidIfpZ4Uh[SC5ZXXr	NEfNcGs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{iwPFMzPyd-MkO4NFg{Ojd:L3G+
HeLa	Mm\vSpVv[3Srb36gZZN{[Xl?	NG\nSoQyOCC2bzCxNFAxKG6P	NH\0e\|Y1QCCqcoO=	MY\Jcohq[mm2aX;uJI9nKEG3cn;yZUBscW6jc3WgRkBqdiCqdX3hckBJ\UyjIHPlcIx{KGG\|c3Xzd4VlKGG\|IHTlcIF6KGmwIH3peI91cWNiYYLy[ZN1KGK7IHHjZ5VufWyjdHnvckBw\iCvdXz0bY52[2ynYYTl[EBk\WyuczD3bZRpKDSQL{jOJGRPSSClb370[Y51KGG2IEGwJJRwKDFyMECgcm0h[W[2ZYKgOFghcHK\|IHL5JJBzd3CrZHn1cUBqd2SrZHWgd5RicW6rbnetZoF{\WRiRlHDV{BndG:5IHP5eI9u\XS{aXOgZY5idHm\|aYO=	M4jxUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OEC4N\|I4Lz5{M{iwPFMzPzxxYU6=
MOLT4	MUPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NVrzVIVCPzJiaILz	MoLQRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCPT1zUOEBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDh[pRmeiB5MjDodpMh[nliQ1PLPEBie3OjeTygTWM2OD1yLkCyNVLPxE1?	M3rNN\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkixNFY3Lz5{NE[4NVA3PjxxYU6=
U937	M3SwPWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		M4n5UVczKGi{cx?=	NW\pUZcySW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDVPVM4KGOnbHzzJIF{e2W\|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDDR2s5KGG\|c3H5MEBKSzVyPUCuNFM3\|ryP	NW\md4NqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2PFExPjZpPkK0OlgyODZ4PD;hQi=>
HL60	M2frVWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NWrDc\|hSPzJiaILz	NUPyS2F7SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIUFYxKGOnbHzzJIF{e2W\|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDDR2s5KGG\|c3H5MEBKSzVyPUCuNFM5Os7:TR?=	NXTpR2wxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2PFExPjZpPkK0OlgyODZ4PD;hQi=>
K562	MVXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NGjySJo4OiCqcoO=	M1zGSmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDh[pRmeiB5MjDodpMh[nliQ1PLPEBie3OjeTygTWM2OD1yLkC3PVHPxE1?	NGfrfmw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[4NVA3Pid-MkS2PFExPjZ:L3G+
MDA-MB-231	M3nBfWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NFj2SWQ4OiCqcoO=	MVLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQT3NRk0zOzFiY3XscJMh[XO\|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgO\|IhcHK\|IHL5JGNEUzhiYYPzZZktKEmFNUC9NE4yOjgQvF2=	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ6MUC2Okc,OjR4OEGwOlY9N2F-
A431	MXPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		M2rlOFczKGi{cx?=	MWXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF2M{GgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KEOFS{igZZN{[XluIFnDOVA:OC5{NN88US=>	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ6MUC2Okc,OjR4OEGwOlY9N2F-
DU145	Moj6RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		M1O0RlczKGi{cx?=	M3L6N2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iRGWxOFUh[2WubIOgZZN{\XO\|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiN{KgbJJ{KGK7IFPDT\|gh[XO\|YYmsJGlEPTB;MD60{txO	NGTacpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[4NVA3Pid-MkS2PFExPjZ:L3G+
MCF7	MUDBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MXO3NkBpenN?	NEm1ZlFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZZN{\XO\|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiN{KgbJJ{KGK7IFPDT\|gh[XO\|YYmsJGlEPTB;MT6z{txO	M4TrO\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkixNFY3Lz5{NE[4NVA3PjxxYU6=
HeLa	NVrRfIhoSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NY\hTnhrPzJiaILz	NFHGOoJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjlUIEh[2WubIOgZZN{\XO\|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiN{KgbJJ{KGK7IFPDT\|gh[XO\|YYmsJGlEPTB;Mj65N:69VQ>?	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ6MUC2Okc,OjR4OEGwOlY9N2F-
A549	MXvBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MWK3NkBpenN?	NFe3PGtCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZZN{\XO\|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiN{KgbJJ{KGK7IFPDT\|gh[XO\|YYmsJGlEPTB;Mz6wOe69VQ>?	M2nDSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkixNFY3Lz5{NE[4NVA3PjxxYU6=
PANC1	M33Md2FvfGmycn;sbYZmemG2aY\lJIF{e2G7		NV7VS5BjPzJiaILz	NHLwfnNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGDBUmMyKGOnbHzzJIF{e2W\|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDDR2s5KGG\|c3H5MEBKSzVyPUSuNVPPxE1?	M2K0Z\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkixNFY3Lz5{NE[4NVA3PjxxYU6=
HCT116	Mn7uRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MnLBO\|IhcHK\|	NFfpVI9CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFEyPiClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgR2NMQCCjc4PhfUwhUUN3ME20MlMz\|ryP	M2TiclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkixNFY3Lz5{NE[4NVA3PjxxYU6=
PC3	MmHtRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NGHp[oQ4OiCqcoO=	MknxRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCSQ{OgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KEOFS{igZZN{[XluIFnDOVA:PS56Md88US=>	M1vrb\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkixNFY3Lz5{NE[4NVA3PjxxYU6=
SKBR3	NFu2dJVCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		M1HxeFczKGi{cx?=	NGDCPG1CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPLRnI{KGOnbHzzJIF{e2W\|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDDR2s5KGG\|c3H5MEBKSzVyPUmuPVnPxE1?	NFzxR3o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[4NVA3Pid-MkS2PFExPjZ:L3G+
NCI-N87	NIHDWY5CdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NULWNpZrPzJiaILz	M2LafWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMW45PyClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgR2NMQCCjc4PhfUwhUUN3ME2xNU43\|ryP	NETzNZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[4NVA3Pid-MkS2PFExPjZ:L3G+
HepG2	MoroR5l1d3SxeHnjbZR6KGG\|c3H5		Mkn1OFghcHK\|	MkDuR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgOFghcHK\|IHL5JG1VXCCjc4PhfUwhXEN3ME2zMlPPxE1?	NEj4foQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmxNFc3Pid-MkS5NVA4PjZ:L3G+
HeLa	NYnFdHF2TnWwY4Tpc44h[XO\|YYm=		NIC5ZmMyOiCqcoO=	NVXuR4VrUW6qaXLpeIlwdiCxZjDBeZJwemFiQTDpckBpfW2jbjDI[WxiKGOnbHzzJIFnfGW{IEGyJIhzeyCkeTDFUGlUSSCvZYToc4QtKEmFNUC9NE4zPjIQvF2=	NFTQfHk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUixNlk3Pyd-MkW4NVI6Pjd:L3G+
HeLa	NFjMRoJHfW6ldHnvckBie3OjeR?=		NYLGSotLOTJiaILz	M3LHS2lvcGmkaYTpc44hd2ZiQYXyc5JiKEJiaX6gbJVu[W5iSHXMZUBk\WyuczDh[pRmeiBzMjDodpMh[nliRVzJV2EhdWW2aH;kMEBKSzVyPUCuOFU{\|ryP	NWT4T\|R4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4NVI6PjdpPkK1PFEzQTZ5PD;hQi=>
A549	MX7DfZRwfG:6aXPpeJkh[XO\|YYm=		MXy0PEBpenN?	MX\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTB;MUmuOO69VQ>?	NV;2UodRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4NVI6PjdpPkK1PFEzQTZ5PD;hQi=>
HeLa	NIi0TZpEgXSxdH;4bYNqfHliYYPzZZk>		MVS0PEBpenN?	Ml\qR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVN[SClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG\|c3H5MEBKSzVyPUK3MlPPxE1?	NGXjTVc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUixNlk3Pyd-MkW4NVI6Pjd:L3G+
HCT8	Ml;pR5l1d3SxeHnjbZR6KGG\|c3H5		Mkn3OFghcHK\|	M4HKemN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhEXDhiY3XscJMh[W[2ZYKgOFghcHK\|IHL5JG1VXCCjc4PhfUwhUUN3ME20OE43\|ryP	NEXX[Go9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUixNlk3Pyd-MkW4NVI6Pjd:L3G+
Hela	Mn7OSpVv[3Srb36gZZN{[Xl?			NEXoTY5KdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JGF2em:{YTDBJItqdmG\|ZTDk[ZJqfmWmIH\yc40hcHWvYX6gTIVt[SClZXzsd{B2e2mwZzDr[Y1xfGmmZTDhd{B{fWK\|dILheIUhcW5icILld4Vv[2Vib3[gX4MuOzKSXVHUVEwhU2l;MD6wNFLPxE1?	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzh6NE[5O{c,Ojd6OES2PVc9N2F-
NCI-H23	NFH1W3lCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=			NX\1cGlESW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOR2kuUDJ\|IHPlcIx{KGijcnLvdolv\yCNUlHTJGcyOkNibYX0ZY51KGG2	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB\|OEm0NEc,OjhyM{i5OFA9N2F-
NCI-H358	NXrQOGRkSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=			NUnWUJRJSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOR2kuUDN3ODDj[YxteyCqYYLic5JqdmdiS2LBV{BIOTKFIH31eIFvfCCjdB?=	MljTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyM{i5OFAoRjJ6MEO4PVQxRC:jPh?=
U937	MUXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NEjTbXI1QCCqcoO=	MW\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFV7M{egZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KEOFS{igZZN{[XluIFnDOVA:OC5yM{dOwG0>	MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTN3OEG0O{c,Ojl\|NUixOFc9N2F-
K562	MoXXRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		M1vz[\|Q5KGi{cx?=	NXLST\|gxSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDDR2s5KGG\|c3H5MEBKSzVyPUCuNFc6\|ryP	NHTBSJE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUO1PFE1Pyd-MkmzOVgyPDd:L3G+
MDA-MB-231	MofORY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NXjzc2dYPDhiaILz	MUDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQT3NRk0zOzFiY3XscJMh[W[2ZYKgOFghcHK\|IHL5JGNEUzhiYYPzZZktKEmFNUC9NE4yOjgQvF2=	NFTldY09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUO1PFE1Pyd-MkmzOVgyPDd:L3G+
A431	MXnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NH62XoY1QCCqcoO=	MoL0RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCDNEOxJINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCFQ1u4JIF{e2G7LDDJR\|UxRTBwMkVOwG0>	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTN3OEG0O{c,Ojl\|NUixOFc9N2F-
MCF7	M4mxO2FvfGmycn;sbYZmemG2aY\lJIF{e2G7		MlvROFghcHK\|	M1;TTmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB2ODDodpMh[nliQ1PLPEBie3OjeTygTWM2OD1zLkROwG0>	NHu1VJA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUO1PFE1Pyd-MkmzOVgyPDd:L3G+
HeLa	Mn\lRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NUPSdY9qPDhiaILz	MnXXRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCKZVzhJINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCFQ1u4JIF{e2G7LDDJR\|UxRTJwOUROwG0>	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTN3OEG0O{c,Ojl\|NUixOFc9N2F-
HCT116	NYLGU2xtSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MnziOFghcHK\|	NXvofINpSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[W[2ZYKgOFghcHK\|IHL5JGNEUzhiYYPzZZktKEmFNUC9OE4{Os7:TR?=	M4rxRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7M{W4NVQ4Lz5{OUO1PFE1PzxxYU6=
TC32	NUXWWXdFeUiWUzDhd5NigQ>?			MWnxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhXEN\|MjDj[Yxtew>?	MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
A673	NUex[m5jeUiWUzDhd5NigQ>?			NV:xRm1seUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IFG2O\|Mh[2WubIO=	NIXYO4U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
SK-N-MC	MXnxTHRUKGG\|c3H5			MVzxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhW0tvTj3NR{Bk\Wyucx?=	NFflN\|Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
NB-EBc1	MnjQdWhVWyCjc4PhfS=>			MWDxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhVkJvRVLjNUBk\Wyucx?=	MkTIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
SK-N-SH	M2KzcpFJXFNiYYPzZZk>			MX7xTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhW0tvTj3TTEBk\Wyucx?=	M2TSbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
NB1643	MkHpdWhVWyCjc4PhfS=>			NHjRcIdyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiTlKxOlQ{KGOnbHzz	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
LAN-5	M3HEbpFJXFNiYYPzZZk>			NG\CSFdyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiTFHOMVUh[2WubIO=	MneyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
BT-12	MVvxTHRUKGG\|c3H5			MmS4dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKEKWLUGyJINmdGy\|	NH\UT5o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
Rh18	M334SJFJXFNiYYPzZZk>			NWPWUXpSeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IGLoNVgh[2WubIO=	NFm4[409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
OHS-50	MVTxTHRUKGG\|c3H5			NW\qRpE5eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IF;IV{02OCClZXzsdy=>	MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
RD	NYPKfWxVeUiWUzDhd5NigQ>?			NIXSXo9yUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiUlSgZ4VtdHN?	Mn3NQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
MG 63 (6-TG R)	NFPDR5ByUFSVIHHzd4F6			NGe1RoFyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiTVegOlMhMDZvVFegVkkh[2WubIO=	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
Rh30	M4S5W5FJXFNiYYPzZZk>			NVHqNnJueUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IGLoN\|Ah[2WubIO=	NGL3d4s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
Rh41	NH3CUHFyUFSVIHHzd4F6			NXO2blFQeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IGLoOFEh[2WubIO=	MmHxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
NB1643	MmrBdWhVWyCjc4PhfS=>			MnT1dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgUmIyPjR\|IHPlcIx{	M3;vR\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
A673	MYjxTHRUKGG\|c3H5			MVrxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDBOlc{KGOnbHzzLS=>	M3LVV\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SK-N-MC	NWPIZ2tjeUiWUzDhd5NigQ>?			NX\sVHIxeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhW0tvTj3NR{Bk\Wyucx?=	NE\ZN3A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
DAOY	M3XNOZFJXFNiYYPzZZk>			NEDlT\|ByUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBFSU:\IHPlcIx{	NX73SYVZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
TC32	MlHodWhVWyCjc4PhfS=>			NGTxUm1yUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBVSzN{IHPlcIx{	M135dlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
MG 63 (6-TG R)	NVjsVWwxeUiWUzDhd5NigQ>?			MnnCdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgUWchPjNiKE[tWGchWiliY3XscJM>	M3zoclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
U-2 OS	MmC0dWhVWyCjc4PhfS=>			MnzDdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgWU0zKE:VIHPlcIx{	NWDIOVh4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
Rh41	M1j3WZFJXFNiYYPzZZk>			NIXTZo5yUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBTcDRzIHPlcIx{	MmGxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
Rh30	MmX6dWhVWyCjc4PhfS=>			M2TyOZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJHJpOzBiY3XscJM>	NGLWSYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
Saos-2	NWjRbZRoeUiWUzDhd5NigQ>?			M3HYW5FJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJHNid3NvMjDj[Yxtew>?	NVT3bZRxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
OHS-50	NUPNNXZueUiWUzDhd5NigQ>?			NUO2SmhQeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhV0iVLUWwJINmdGy\|	NEm1dGw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
SK-N-SH	M1[3NpFJXFNiYYPzZZk>			MUDxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDTT{1PNVOKIHPlcIx{	M1T6bVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
L929sA	NIK2OJZHfW6ldHnvckBie3OjeR?=		M4HYS\|I1KGi{cx?=	MULJcohq[mm2aX;uJI9nKEG3cnugcY92e2ViTEmyPZNCKGOnbHzzJJRz[W6\|ZnXjeIVlKHerdHigbJVu[W5iRnHzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKGe{b4f0bEBi\nSncjCyOEBpenNiaX6gdJJme2WwY3Wgc4YhXE6IIHL5JGhw\WOqc4SgN\|M{PDJic4ThbY5qdmdvYnHz[YQhdWmlcn;zZ49xcWNiYYPzZZktKEmFNUC9NE46P87:TR?=	M323N\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO3N\|g3Lz5{OUSzO\|M5PjxxYU6=
L929sA	M{DaWWZ2dmO2aX;uJIF{e2G7		NGe5PVcxNjViaILz	MlS5TY5pcWKrdHnvckBw\iCUSWDLNUBqdiCvb4Xz[UBNQTJ7c1GgZ4VtdHNidILhcpNn\WO2ZXSge4l1cCCqdX3hckBH[XNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBqdiCWTl[tbY5lfWOnZDDu[YNzd3C2b4Ppd{BxemW2cnXheIVlKG[xcjCwMlUhcHK\|IH\vcIxwf2WmIHL5JHRPTiCjbnSgfnZCTC6obXugZYRlcXSrb36gcYVie3W{ZXSgZYZ1\XJiMzDodpMh[nliSH;lZ4h{fCB\|M{O0Nk9xem:yaXTpeY0hcW:maXTlJJN1[WmwaX7nMYJie2WmIHHzd4F6NCCLQ{WwQVAvQTkQvF2=	NHzSbJM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzO\|M5Pid-Mkm0N\|c{QDZ:L3G+
L929sA	MVfGeY5kfGmxbjDhd5NigQ>?		MYSyOEBpenN?	Mm\QTY5pcWKrdHnvckBw\iCUSWDLNUBqdiCvb4Xz[UBNQTJ7c1GgZ4VtdHNidILhcpNn\WO2ZXSge4l1cCCqdX3hckBH[XNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBqdiCWTl[tbY5lfWOnZDDu[YNzd3C2b4Ppd{BxemW2cnXheIVlKG[xcjCyOEBpenNiZn;scI94\WRiYomgWG5HKGGwZDD6WmFFNm[vazDh[IRqfGmxbjDt[YF{fXKnZDDh[pRmeiB\|IHjyd{BjgSCKb3XjbJN1KDN\|M{SyM5Bzd3CrZHn1cUBqd2SrZHWgd5RicW6rbnetZoF{\WRiYYPzZZktKEmFNUC9NU4xOs7:TR?=	M2rhRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO3N\|g3Lz5{OUSzO\|M5PjxxYU6=
L929sA	MljISpVv[3Srb36gZZN{[Xl?		NH\TZlQzPCCqcoO=	MkX3TY5pcWKrdHnvckBw\iCDdYLrJI1wfXOnIFy5Nll{SSClZXzsd{B1emGwc3\lZ5Rm\CC5aYToJIh2dWGwIF\hd{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDueYNt\WG{IHHy[YEh[W[2ZYKgNlQhcHK\|IHnuJJBz\XOnbnPlJI9nKFSQRjDifUBJd2WlaIP0JFM{OzR{IIP0ZYlvcW6pLXLhd4VlKG2rY4Lvd4NweGmlIHHzd4F6NCCLQ{WwQVEvODcQvF2=	NVv0b5V5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|c{QDZpPkK5OFM4Ozh4PD;hQi=>
HCT116	M1q5NWN6fG:2b4jpZ4l1gSCjc4PhfS=>		M1vH[VQ5KGi{cx?=	Mlq3R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGNVOTF4IHPlcIx{KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTBwNEZOwG0>	M2G2ZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUSzOFI{Lz5\|MEG0N\|QzOzxxYU6=
HCT15	Mom4R5l1d3SxeHnjbZR6KGG\|c3H5		MX60PEBpenN?	M3;Jd2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhEXDF3IHPlcIx{KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTFwMkROwG0>	M1TOelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUSzOFI{Lz5\|MEG0N\|QzOzxxYU6=
HCT116	MVfGeY5kfGmxbjDhd5NigQ>?	NXW2dIZ4OTByIH7N	MmTTNlQhcHK\|	MoPLTY5pcWKrdHnvckBw\iCleYTvb4lv\XOrczDpckBpfW2jbjDIR3QyOTZiY3XscJMh[XRiMUCwJI5OKGGodHXyJFI1KGi{czDifUBxem:yaXTpeY0hcW:maXTlM3JP[XOnIIP0ZYlvcW6pLXLhd4VlKG[ub4egZ5l1d22ndILpZ{BidmGueYPpdy=>	M{TmflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUSzOFI{Lz5\|MEG0N\|QzOzxxYU6=
HCT116	Mn;CSpVv[3Srb36gZZN{[Xl?	NVLzUJJROSC3TR?=	NXXTdWxiOjRiaILz	NFjicGNKdmirYnn0bY9vKG:oIHP5eI9scW6nc3nzJIlvKGi3bXHuJGhEXDFzNjDj[YxteyCjdDCxJJVOKGGodHXyJFI1KGi{czDifUBxem:yaXTpeY0hcW:maXTlM3JP[XOnIIP0ZYlvcW6pLXLhd4VlKG[ub4egZ5l1d22ndILpZ{BidmGueYPpdy=>	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODF2M{SyN{c,OzBzNEO0NlM9N2F-
HCT116	MV3GeY5kfGmxbjDhd5NigQ>?	M4TNZ\|EhfU1?	M4TGcVMhcHK\|	MWLJcohq[mm2aX;uJI9nKEG3cn;yZUBDKGmwIHj1cYFvKEiFVEGxOkBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iaHnzeI9v\SCKMzDwbI9{eGixconsZZRqd25iYYSgV4VzOTBicnXzbYR2\SC3cDD0c{AyKHWPIHHmeIVzKDNiaILzJIJ6KFenc4Tldo4h[myxdDDhcoFtgXOrcx?=	Mm\DQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzBzNEO0NlMoRjNyMUSzOFI{RC:jPh?=
HCT116	NEfkUFlHfW6ldHnvckBie3OjeR?=		MofHN{BpenN?	NF7VXlRKdmirYnn0bY9vKG:oIFH1do9z[SCDIIDoc5NxcG:{eXzheIlwdiCjdDDUbJIzQDhicnXzbYR2\SCrbjDoeY1idiCKQ2SxNVYh[2WubIOgeZAhfG9iMTD1UUBi\nSncjCzJIhzeyCkeTDX[ZN1\XKwIHLsc5Qh[W6jbInzbZM>	M3nyXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUSzOFI{Lz5\|MEG0N\|QzOzxxYU6=
HCT116	NXSyeJJMTnWwY4Tpc44h[XO\|YYm=		NWniU2J7OyCqcoO=	M{HIemlvcGmkaYTpc44hd2ZiQYXyc5JiKEJicHjvd5Bpd3K7bHH0bY9vKGG2IGTodlI{OiC{ZYPp[JVmKGmwIHj1cYFvKEiFVEGxOkBk\WyuczD1dEB1dyBzIIXNJIFnfGW{IEOgbJJ{KGK7IGfld5Rmem5iYnzveEBu\XSqb3S=	MkOwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzBzNEO0NlMoRjNyMUSzOFI{RC:jPh?=
Sf9	MlX2SpVv[3Srb36gZZN{[Xl?			M17oVGlvcGmkaYTpc44hd2ZiR2PUMZRi\2enZDDBWXJQWkFiQTCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBj[WO3bH;2bZJ2eyCrbn\lZ5Rm\CCVZkmgZ4VtdHNidYPpcochVUKSIHHzJJN2[nO2cnH0[UwhUUN3ME2wMlAzO87:TR?=	NFP4eXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEKzOFk5Pyd-M{CyN\|Q6QDd:L3G+
HeLa	NH71RYpHfW6ldHnvckBie3OjeR?=		M1\JcFEzKGi{cx?=	M4TK[2lvcGmkaYTpc44hd2ZiQYXyc5JiKEFicHjvd5Bpd3K7bHH0bY9vKGG2IGTodlI5QCC{ZYPp[JVmKGmwIHj1cYFvKEinTHGgZ4VtdHNiYX\0[ZIhOTJiaILzJIJ6KEWOSWPBMEBKSzVyPUCuNFE{\|ryP	MlzsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB3MEKxNVUoRjNyNUCyNVE2RC:jPh?=
HeLa	NVnmUFloTnWwY4Tpc44h[XO\|YYm=		NIXRTGUyOiCqcoO=	NIq4doFKdmirYnn0bY9vKG:oIFH1do9z[SCEIIDoc5NxcG:{eXzheIlwdiCjdDDUbJIzOzJicnXzbYR2\SCrbjDoeY1idiCKZVzhJINmdGy\|IHHmeIVzKDF{IHjyd{BjgSCHTFnTRUwhUUN3ME2wMlE1QM7:TR?=	MoLuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB3MEKxNVUoRjNyNUCyNVE2RC:jPh?=
A549	M3;ZV2FvfGmycn;sbYZmemG2aY\lJIF{e2G7		Mm\IOFghcHK\|	MnXxRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCDNUS5JINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFfJOVA:OzVwON88US=>	NIXnSFA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEWwNlEyPSd-M{C1NFIyOTV:L3G+
LoVo	NE\je4ZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MlXoOFghcHK\|	M2ixRWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTH;Wc{Bk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDHTVUxRTR3LkROwG0>	NHnyVIM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEWwNlEyPSd-M{C1NFIyOTV:L3G+
HeLa	MkDlRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NIi0SHg1QCCqcoO=	MlTrRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCKZVzhJINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFfJOVA:PDZwMt88US=>	NYnse4VMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C1NFIyOTVpPkOwOVAzOTF3PD;hQi=>
HeLa	NWjD[XFtS2WubDDjfYNt\SCjc4PhfS=>	MlHLOUB2VQ>?	NETYbVcyOiCqcoO=	NIXDenZE\WyuIHP5Z4xmKGG{cnXzeEBqdiCqdX3hckBJ\UyjIHPlcIx{KGG\|c3Xzd4VlKGG\|IHTlZ5Jm[XOnIHnuJIN6[2yrbjDCNUBxem:2ZXnuJIV5eHKnc4Ppc44h[XRiNTD1UUBi\nSncjCxNkBpenNiYomgW4V{fGW{bjDicI91KGGwYXz5d4l{	MojDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB3MEKxNVUoRjNyNUCyNVE2RC:jPh?=
HeLa	M1XGdmNmdGxiY4njcIUh[XO\|YYm=	NWTmbZdtPSC3TR?=	NXLtT2NTOTJiaILz	M2rTcmNmdGxiY4njcIUh[XK{ZYP0JIlvKGi3bXHuJGhmVGFiY3XscJMh[XO\|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4RkOiCycn;0[YlvKGW6cILld5Nqd25iYYSgOUB2VSCjZoTldkAyOiCqcoOgZpkhX2W\|dHXyckBjdG:2IHHuZYx6e2m\|	NEjtbW49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEWwNlEyPSd-M{C1NFIyOTV:L3G+
HeLa	MWDGeY5kfGmxbjDhd5NigQ>?	MmGyOUB2VQ>?	NVPtXFlMOTJiaILz	M4LYdGlvcGmkaYTpc44hd2ZiQYXyc5JiKEFicHjvd5Bpd3K7bHH0bY9vKGG2IGTodlI5QCC{ZYPp[JVmKGmwIHj1cYFvKEinTHGgZ4VtdHNiYYSgOUB2VSCjZoTldkAyOiCqcoOgZpkhX2W\|dHXyckBjdG:2IHHuZYx6e2m\|	MmLXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB3MEKxNVUoRjNyNUCyNVE2RC:jPh?=
HeLa	M2DGNmZ2dmO2aX;uJIF{e2G7	M1XJ[FUhfU1?	MoHlNVIhcHK\|	NUjLb3loUW6qaXLpeIlwdiCxZjDBeZJwemFiQjDwbI9{eGixconsZZRqd25iYYSgWIhzOjN{IILld4llfWViaX6gbJVu[W5iSHXMZUBk\WyuczDheEA2KHWPIHHmeIVzKDF{IHjyd{BjgSCZZYP0[ZJvKGKub4SgZY5idHm\|aYO=	NH7Uc3A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEWwNlEyPSd-M{C1NFIyOTV:L3G+
A549	NIrEZmhCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		M4jZNFQ5KGi{cx?=	M4nUWWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTN3LklOwG0>	MlfXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB5MkixNVIoRjNyN{K4NVEzRC:jPh?=
LoVo	M4\wNGFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NFjxbFE1QCCqcoO=	NUXSbHYzSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDMc3ZwKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTB;NEWuN:69VQ>?	NXf3UG5TRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C3NlgyOTJpPkOwO\|I5OTF{PD;hQi=>
HeLa	MoDGRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NYfQOW96PDhiaILz	MULBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEinTHGgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF01Pi5{zszN	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODd{OEGxNkc,OzB5MkixNVI9N2F-

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	DLK / p-MKK7 / MKK7 / p-JNK / JNK ; PubMed: 23431148 Proc Natl Acad Sci U S A Western blot of the DLK pathway members in RGCs (retinal ganglion cells) 4 h after immunopanning in the presence of 0, 0.03, 0.06, 0.125, 0.25, 0.5, 1, or 2 μM tozasertib. p-AURKA / AURKA / Survivin ; PubMed: 28218735 Oncogenesis BGC823 cells were incubated with indicated doses of VX-680 for 24 h before subjected to western blotting with the indicated antibodies. Densitometry was used to quantify the Survivin and GAPDH levels. The relative expression shown (right panel) are means±s.e.m. of the ratios of Survivin to GAPDH. YAP; PubMed: 31160567 Cell Death Dis Western blot analysis of YAP protein level in A549 cells treated with indicated doses of VX-680 for 24 h. p-AKT / p-GSK3β / Cleaved caspase-3 / Cleaved PARP ; PubMed: 21600017 J Transl Med NB4-R2 cells were collected, lysed and subjected to Western blot analysis with cleaved caspase-3, cleaved-PARP, pAkt-1 (Ser473), pGSK-3β (Ser9) specific antibodies. GAPDH was used as a loading control. Data shown is a representative of three independent experiments.	23431148 28218735 31160567 21600017
Immunofluorescence	α-tubulin / Aurora-A ; PubMed: 21600017 J Transl Med The morphology of mitotic spindle was shown by immunofluorescence staining with anti-α-tubulin antibody and anti-Aur-A antibodies. Microtubules were stained as green, Aur-A protein as red, and nucleus as blue.	21600017
Growth inhibition assay	Cell viability; PubMed: 21600017 J Transl Med VX-680 significantly suppresses the proliferation in a number of leukemic cell types. OCI-AML3, NB4, HL-60 and ML-1 cells were incubated with increasing doses of VX-680 (1, 2, 5 and 10 nM) for 24 hr. Cell viability was measured by MTT assay. Data summarized three independent experiments, p < 0.05, *p < 0.01, compared to control.	21600017

体内研究

VX-680作用于人类AML(HL-60)移植瘤模型明显降低肿瘤尺寸。VX-680按75 mg/kg剂量给药实验鼠,每天腹腔注射两次，持续13天,与对照组相比，平均肿瘤体积下降达98%。肿瘤体积比实验之前初始体积小很多。按12.5 mg/kg剂量每天给药两次，肿瘤生长也明显降低，这种作用存在剂量依赖性。VX-680耐受性很好，只有在使用高剂量时可以观察到实验动物体重稍微降低。通过比较cisplatin,按5.4 mg/kg剂量给药，每四天腹腔注射一次，一共进行三次，抑制肿瘤生长只达9%。VX-680作用于胰脏和结肠移植瘤，也引起肿瘤衰退。VX-680静脉注射给药携带HCT116肿瘤的实验鼠，显示很强的抗癌活性。使用高剂量VX-680(每小时2 mg/kg)处理，明显提高效果，比实验钱的初始肿瘤平均尺寸下降56%。^[1]

激酶实验： ^[3]	- 合并激酶抑制实验: 丙酮酸激酶/乳酸脱氢酶催化NADH的氧化，伴随着ATP的消耗，观察340 nm 处吸光值的降低。反应包括100 mM Tris (pH 为 8), 10 mM MgCl₂, 2.2 mM ATP, 1 mM磷酸烯醇丙酮酸, 0.6 mg/ml NADH, 75 ml丙酮酸激酶, 105 ml 乳酸脱氢酶,和0.5 mM 基底肽(序列为EAIYAAPFAKKK)。加入足够的激酶开始反应，反应的激酶浓度达到30 nM，用微量滴定板分光光度计在30^oC进行30分钟，观察吸收率的降低。通过加入3.75 μl 溶于100% DMSO的VX-680 或单独DMSO，获得抑制常数。按如下公式计算K_i值，K_i = IC50/(1+[S]/K_d),[S]=[ATP]=2.2 mM, K_d=70 μM。假定作用于野生型和H396P Abl 激酶域的K_d(ATP)为70 μM，计算以上各值。
细胞实验： ^[2]	- 合并 Cell lines: CAL-62细胞 Concentrations: 5-500 nM Incubation Time: 4天 Method: 对照组CAL-62细胞培养在二甲亚砜和DMSO中，实验组加入500 nM VX-680，处理1到5天。加入不同浓度(5到500 nM) Aurora抑制剂处理不同ATC细胞4天，用来测定VX-680作用于细胞增殖的剂量依赖性。细胞在温育结束前加30 mM BrdU标记，脉冲2小时。通过比色免疫分析使用细胞增殖ELISA试剂盒分析BrdU的合并率。通过比较VX-680处理的细胞和对照组细胞得到结果， (Only for Reference)
动物实验： ^[1]	- 合并 Animal Models: 右侧腋窝处皮下注射107 HL-60白血病细胞的雌性无胸腺NCr-nu鼠 Dosages: 50 mg/kg, 75 mg/kg Administration: 腹腔注射 (Only for Reference)

参考文献

[4] Cheetham GM, et al. Cancer Lett. 2007, 251(2), 323-329.

- 合并

溶解度 (25°C)

体外	DMSO	93 mg/mL (200.17 mM)
	Water	Insoluble
	Ethanol	Insoluble
体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： 5% DMSO+30% PEG 300+2% Tween 80+ddH2O	3.75 mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download Tozasertib (VX-680, MK-0457) SDF

分子量	464.59
化学式	C₂₃H₂₈N₈OS
CAS号	639089-54-6
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	N/A

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

临床试验信息 (data from https://clinicaltrials.gov, updated on 2021-05-17)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT00290550	Terminated	Drug: MK0457	Carcinoma Non-Small-Cell Lung	Merck Sharp & Dohme Corp.	June 2006	Phase 2
NCT00111683	Completed	Drug: MK0457	Chronic Myelogenous Leukemia in Blast Crisis\|Lymphocytic Leukemia B Cell Acute\|Myelodysplastic Syndromes\|Myelogenous Leukemia Chronic	Merck Sharp & Dohme Corp.	June 2005	Phase 1

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

Aurora Kinase Signaling Pathway Map

Aurora Kinase Inhibitors with Unique Features

泛Aurora Kinase抑制剂

Danusertib (PHA-739358) : Pan-Aurora kinase inhibitor, Aurora A/B/C, IC50=13 nM/79 nM/61 nM.
泛Aurora Kinase抑制剂

SNS-314 Mesylate : Pan-Aurora kinase inhibitor, Aurora A/B/C, IC50=9 nM/31 nM/3 nM.
活性最高的Aurora Kinase抑制剂

MK-5108 (VX-689) : Aurora A, IC50=0.064 nM.
用于临床的Aurora Kinase抑制剂

Alisertib (MLN8237) : Phase III for Relapsed/Refractory Peripheral T-Cell Lymphoma.
经典的Aurora Kinase抑制剂

Hesperadin : Potently inhibits Aurora B with IC50 of 250 nM.

研究领域

产品类型

定制您的化合物库

Tozasertib (VX-680, MK-0457)

客户使用Selleck生产的Tozasertib (VX-680, MK-0457)发表文献102篇：

产品安全说明书

Aurora Kinase抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download Tozasertib (VX-680, MK-0457) SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

临床试验信息 (data from https://clinicaltrials.gov, updated on 2021-05-17)

技术支持

Aurora Kinase Signaling Pathway Map

Aurora Kinase Inhibitors with Unique Features

相关Aurora Kinase产品