Tozasertib (VX-680, MK-0457)

For research use only. Not for use in humans.

目录号：S1048 中文名称：陶扎色替

Tozasertib (VX-680, MK-0457) Chemical Structure

CAS No. 639089-54-6

Tozasertib (VX-680, MK-0457)是一种pan-Aurora抑制剂，对Aurora A作用最强，无细胞试验中K_iapp为0.6 nM，而对Aurora B/Aurora C的作用较弱，对Aurora A选择性比其他55种激酶高100倍。唯二的例外是 Fms-related tyrosine kinase-3 (FLT-3) 和 BCR-ABL tyrosine kinase，也可被 Tozasertib 抑制，对应的Ki值均为30 nM和30 nM。Tozasertib 可诱导凋亡和自噬。Phase 2。

规格

价格

库存

购买数量

10mM (1mL in DMSO)	RMB 1098.34	现货
25mg	RMB 1211.51	现货
250mg	RMB 3833.09	现货
300mg	RMB 4316.13	现货
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客户使用Selleck生产的Tozasertib (VX-680, MK-0457)发表文献110篇：

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产品安全说明书

Aurora Kinase抑制剂选择性比较

生物活性

产品描述

靶点

Aurora A ^[1] (Cell-free assay)	Aurora C ^[1] (Cell-free assay)	Aurora B ^[1] (Cell-free assay)	FLT3 ^[4] (Cell-free assay)	Bcr-Abl ^[4] (Cell-free assay)
0.6 nM(Ki app)	4.6 nM(Ki app)	18 nM(Ki app)	30 nM(Ki)	30 nM(Ki)

体外研究

虽然VX-680具有多激酶特性，VX-680却诱导相似的细胞毒性，IC50约为300 nM，在G2/M期，核内复制期，及转染ABL或FLT-3激酶的BaF3细胞凋亡时，显示一个Aurora B 类似的抑制表现型。VX-680抑制CAL-62细胞增殖，这种作用存在时间依赖性。用VX-680处理14天，明显降低群体的数量和大小，处理8305C下降达到70%，处理CAL-62, 8505C,和BHT-101下降达到90%。用VX-680处理不同ATC细胞，抑制细胞增殖，IC50为25到150 nM，这种作用存在时间和剂量依赖性。在软琼脂中，VX-680明显削弱不同细胞系形成群落的能力。caspase-3的活性分析显示VX-680诱导不同细胞凋亡。VX-680处理CAL-62 细胞12小时，形成DNA含量≥4N细胞累积物。微速摄影分析显示VX-680处理的CAL-62细胞离开细胞中期。VX-680可以抑制组蛋白H3的磷酸化作用。^[2] VX-680作用于携带T315I突变的BCR-Abl的病人样本，具有明显抑制活性。^[3]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
BE-13	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			M{O0SWlEPTB;MD6wNFM{QCEQvF2=	MnT1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
RS4-11	NEnGPI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M{exd2lEPTB;MD6wNFQxPCEQvF2=	NFfT[Gs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
MFH-ino	NVHBS4R[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NXLabVY1UUN3ME2wMlAxQTlizszN	M{TXUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
NTERA-S-cl-D1	NXzTfVZ[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NXftNIVyUUN3ME2wMlAyPDN2IN88US=>	NUDFdVRxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
697	M163VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NYPkWlIzUUN3ME2wMlAzPDdzIN88US=>	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
NALM-6	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MULJR\|UxRTBwMEK1OVIh\|ryP	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
ES8	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NULhdpBqUUN3ME2wMlA1PjF\|IN88US=>	NEf0cJQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
HUTU-80	M3\DVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NH\0[ZhKSzVyPUCuNFUzQTlizszN	MmHGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
MV-4-11	NH7r[\|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NUHaWVBrUUN3ME2wMlA4Pzh{IN88US=>	NFOwO4U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
MONO-MAC-6	NXjGfot[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MVXJR\|UxRTBwMEe4O\|kh\|ryP	NGXRRVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
LC-2-ad	M4nJT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NITaVoxKSzVyPUCuNFg4QDlizszN	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
BL-41	NXGzN4JvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			Ml7PTWM2OD1yLkGwOFQ2KM7:TR?=	MnjsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
A4-Fuk	NYjYTI5oT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MUjJR\|UxRTBwMUG1OlMh\|ryP	MljTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
SW954	M17TR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M4fQPWlEPTB;MD6xNlIzQSEQvF2=	MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
BV-173	M{S5UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M2jrcGlEPTB;MD6xNlY1OSEQvF2=	M3vCOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
TE-11	M2O2Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MWrJR\|UxRTBwMUS5PFIh\|ryP	NUHJbIFURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
SK-UT-1	NWHkR4s6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MlHkTWM2OD1yLkG1PVY2KM7:TR?=	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
SIG-M5	NHL5OFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MVnJR\|UxRTBwMU[3NFch\|ryP	NVfnUppORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
OCUB-M	NF3qUpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M3TW[WlEPTB;MD6xOlk5OyEQvF2=	M4DG[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
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TE-15	M2X0Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M4LjNGlEPTB;MD64OVA6QCEQvF2=	NUGyRXRyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
HOP-62	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			Mo\XTWM2OD1yLki2N\|I6KM7:TR?=	NX;rcpF1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
TGBC24TKB	NGjDRmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NIXIU3hKSzVyPUCuPFY{QDVizszN	NUDRe4FKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
HCE-4	MnrPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NHHBZWhKSzVyPUCuPFgxPjNizszN	NGfGXHU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
ALL-PO	Ml3KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			M3npOGlEPTB;MD64PFE4PSEQvF2=	NW\NVIlrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
KGN	NIi5bmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M3m0d2lEPTB;MD64PVk6PSEQvF2=	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
ML-2	NX;MdHVZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MXHJR\|UxRTBwOUCyOVkh\|ryP	NHXMXI09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
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SF126	M1TYR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NHXIWXBKSzVyPUCuPVQ5OTlizszN	NHP3cpQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
SK-N-DZ	NGnWdGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NF72RW9KSzVyPUCuPVYyQDlizszN	M1HrR\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
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DU-4475	NIHNWGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MmLlTWM2OD1zLkCxO\|U3KM7:TR?=	NYjvWo5lRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
NKM-1	NUnDZZNFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M3zLdGlEPTB;MT6wNlc4PSEQvF2=	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
HL-60	NHn5SXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NFnwbXpKSzVyPUGuNFY2PzRizszN	NYrXb\|dKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
SBC-1	MkjtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MYXJR\|UxRTFwMUK1OFIh\|ryP	M{i1OVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
TE-10	M1XKWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NFe2VmNKSzVyPUGuNVI6PDZizszN	MojXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
ETK-1	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NFWybJFKSzVyPUGuNVM3OTNizszN	Mn;DQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
HAL-01	NYTpRWhKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MY\JR\|UxRTFwMU[3NFkh\|ryP	M4LYfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
BB65-RCC	NIjvVpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M3S4bGlEPTB;MT6xPFAxPSEQvF2=	NHHCVlc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
EW-1	NG\4NFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NIjvRpRKSzVyPUGuNVg2PjJizszN	NYnvXWRpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
SK-NEP-1	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NUi0SodYUUN3ME2xMlIyOTFzIN88US=>	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
SK-LMS-1	NIfJdohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MoHLTWM2OD1zLkKyNlEzKM7:TR?=	M2XZ[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
DEL	MlrTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NV;nRlRtUUN3ME2xMlI2PjR\|IN88US=>	Ml\mQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
GT3TKB	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			M2P0fWlEPTB;MT6yPFA2PyEQvF2=	M375d\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
MOLT-16	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MkDYTWM2OD1zLkO1OFA2KM7:TR?=	MkXlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
CMK	M1PtXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NVfYfZAxUUN3ME2xMlQzOTF5IN88US=>	M4XXN\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
NB5	NWXRcoxDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NHvxcI5KSzVyPUGuOlQzOjlizszN	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
NCI-H1963	NGfqUnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MUPJR\|UxRTFwN{C1PFMh\|ryP	NX7zWZBIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
KURAMOCHI	MkX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			M3\XZmlEPTB;MT63PFkyOSEQvF2=	NFS4e5E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzJ6N{ivK\|5USU6JUlXSQE9iRg>?
TE-8	NETrVHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M4O0U2lEPTB;MT64NFM3QCEQvF2=	MlrnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
NCI-H1304	MnXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NGDPVVdKSzVyPUGuPFMxPzNizszN	NU\ze3d1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
A101D	NGe5Om5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NGrHeHJKSzVyPUGuPFc{QTVizszN	Ml:yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
SCLC-21H	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MnnTTWM2OD1zLkm3NFU4KM7:TR?=	NYDMc2dXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
GB-1	MkDaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MUfJR\|UxRTJwMEG2OFch\|ryP	NXfkWpBwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
KARPAS-45	NIPDd5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NX7KNnB5UUN3ME2yMlAzPjV2IN88US=>	NX3DO45JRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd{OEe4M{c,W0GQR2LFVlww[T5?
ATN-1	NH3BS4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MUHJR\|UxRTJwMEK4OVgh\|ryP	M1m5fFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
NCI-H720	NVHK[ZhZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M4TvfWlEPTB;Mj6wOlI1PCEQvF2=	M2nZbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
RPMI-6666	M3K4W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NF:zRlNKSzVyPUKuNVYzODdizszN	M3H1UVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
NB17	NVm3UppJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NXXkTJhmUUN3ME2yMlI6OjdizszN	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
IST-SL1	NGK1NJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M13HXWlEPTB;Mj6yPVc3PSEQvF2=	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
SH-4	NXXy[ZFPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NUTocnZqUUN3ME2yMlMzPDZ7IN88US=>	M3H0VVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4Ojh5OD:nQnNCVkeURWK8M4E,
K5	NIPQWXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MkfCTWM2OD1{LkSwN\|E6KM7:TR?=	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
OVCAR-4	NGj1VJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NWnLSpVZUUN3ME2yMlQ3OTNizszN	MkDqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVczQDd6Lze+V2FPT1KHUkyvZV4>
ACN	NFriWXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MXvJR\|UxRTJwNUCyNVMh\|ryP	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O\|I5PzhxJ{7TRW5IWkWUPD;hQi=>
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HeLa	NHnQS4ZHfW6ldHnvckBie3OjeR?=		Mnr4NVIhcHK\|	NV3MfXBvUW6qaXLpeIlwdiCxZjDBeZJwemFiQjDpckBpfW2jbjDI[WxiKGOnbHzzJIFnfGW{IEGyJIhzeyCkeTDFUGlUSSCvZYToc4QtKEmFNUC9NE41PTQQvF2=	NGi1NpI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUixNlk3Pyd-MkW4NVI6Pjd:L3G+
A549	MXHDfZRwfG:6aXPpeJkh[XO\|YYm=		MWK0PEBpenN?	MUnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTB;MUmuOO69VQ>?	NYTiU4hFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4NVI6PjdpPkK1PFEzQTZ5PD;hQi=>
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HCT8	NHy5bFJEgXSxdH;4bYNqfHliYYPzZZk>		NEnYTFk1QCCqcoO=	NH7W[VZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJS1R6IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUC9OFQvPs7:TR?=	M{\2ZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEGyPVY4Lz5{NUixNlk3PzxxYU6=
Hela	M{O5[WZ2dmO2aX;uJIF{e2G7			MnHITY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDBeZJwemFiQTDrbY5ie2ViZHXybZZm\CCocn;tJIh2dWGwIFjlcIEh[2WubIOgeZNqdmdia3XtdJRq\GViYYOgd5Vje3S{YYTlJIlvKHC{ZYPlcoNmKG:oIGvjMVMzWF2DVGCsJGtqRTBwMECy{txO	NWq1U4pERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke4PFQ3QTdpPkK3PFg1Pjl5PD;hQi=>
NCI-H23	MojzRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?			MUjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE6FST3INlMh[2WubIOgbIFz[m:{aX7nJGtTSVNiR{GyR{BufXSjboSgZZQ>	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB\|OEm0NEc,OjhyM{i5OFA9N2F-
NCI-H358	NX:0c5NpSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=			MoL0RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCQQ1mtTFM2QCClZXzsd{Bp[XKkb4LpcochU1KDUzDHNVJEKG23dHHueEBifA>?	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB\|OEm0NEc,OjhyM{i5OFA9N2F-
U937	MU\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		M1fTS\|Q5KGi{cx?=	NX\qTVVSSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDVPVM4KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDDR2s5KGG\|c3H5MEBKSzVyPUCuNFM3\|ryP	MorxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl\|NUixOFcoRjJ7M{W4NVQ4RC:jPh?=
K562	MULBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NF\RPZI1QCCqcoO=	M3XGXGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczDh[pRmeiB2ODDodpMh[nliQ1PLPEBie3OjeTygTWM2OD1yLkC3Pe69VQ>?	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTN3OEG0O{c,Ojl\|NUixOFc9N2F-
MDA-MB-231	NWfsSlJMSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MnfOOFghcHK\|	NGTpdpFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KEOFS{igZZN{[XluIFnDOVA:OC5zMkhOwG0>	MnP5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl\|NUixOFcoRjJ7M{W4NVQ4RC:jPh?=
A431	M2fSXmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MXu0PEBpenN?	NU\EPVJRSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOFMyKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDDR2s5KGG\|c3H5MEBKSzVyPUCuNlTPxE1?	NYTU[G9DRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmzOVgyPDdpPkK5N\|U5OTR5PD;hQi=>
MCF7	M{LQWWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NFS1SFI1QCCqcoO=	MlWyRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCPQ1[3JINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCFQ1u4JIF{e2G7LDDJR\|UxRTFwM988US=>	M1HVbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7M{W4NVQ4Lz5{OUO1PFE1PzxxYU6=
HeLa	NVrrSmR{SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NInobGU1QCCqcoO=	NG[0T3FCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjlUIEh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IFPDT\|gh[XO\|YYmsJGlEPTB;Mj65N:69VQ>?	M4jQ[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7M{W4NVQ4Lz5{OUO1PFE1PzxxYU6=
HCT116	M{HQPGFvfGmycn;sbYZmemG2aY\lJIF{e2G7		M1rTTlQ5KGi{cx?=	NGPsXGpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFEyPiClZXzsd{Bi\nSncjC0PEBpenNiYomgR2NMQCCjc4PhfUwhUUN3ME20MlMz\|ryP	M3nKWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7M{W4NVQ4Lz5{OUO1PFE1PzxxYU6=
TC32	MXnxTHRUKGG\|c3H5			MXLxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhXEN\|MjDj[Yxtew>?	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
A673	NGi0c3NyUFSVIHHzd4F6			M{PZW5FJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCDNkezJINmdGy\|	M2myVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
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NB1643	MVXxTHRUKGG\|c3H5			MknRdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKE6EMU[0N{Bk\Wyucx?=	Mkm1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
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MG 63 (6-TG R)	M{DXeZFJXFNiYYPzZZk>			MVLxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhVUdiNkOgLFYuXEdiUjmgZ4VtdHN?	NFrSRm09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
Rh30	M2TodJFJXFNiYYPzZZk>			Mn;adWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKFKqM{CgZ4VtdHN?	NXizWJBYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
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NB1643	MWPxTHRUKGG\|c3H5			M3m5cJFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJG5DOTZ2MzDj[Yxtew>?	Mlm3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
A673	NGfDS3VyUFSVIHHzd4F6			NH65cVRyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBCPjd\|IHPlcIx{MQ>?	MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
SK-N-MC	M4\xOZFJXFNiYYPzZZk>			M3:zUZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJHNMNU5vTVOgZ4VtdHN?	MmjPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
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HeLa	NFLMfpBHfW6ldHnvckBie3OjeR?=	M{fzZlUhfU1?	NGH3OFIyOiCqcoO=	MYjJcohq[mm2aX;uJI9nKEG3cn;yZUBDKHCqb4PwbI9zgWyjdHnvckBifCCWaIKyN\|IhemW\|aXT1[UBqdiCqdX3hckBJ\UyjIHPlcIx{KGG2IEWgeW0h[W[2ZYKgNVIhcHK\|IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>?	MoG0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB3MEKxNVUoRjNyNUCyNVE2RC:jPh?=
A549	MUXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NFLKemg1QCCqcoO=	NEHidmFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1\|NT64{txO	NHXzUYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEeyPFEyOid-M{C3NlgyOTJ:L3G+
LoVo	MYnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MVW0PEBpenN?	MlrIRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCOb2\vJINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:PDVwM988US=>	M1zwRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyN{K4NVEzLz5\|MEeyPFEyOjxxYU6=
HeLa	M2HwZ2FvfGmycn;sbYZmemG2aY\lJIF{e2G7		M2fPcVQ5KGi{cx?=	Mm[wRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCKZVzhJINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:PDZwMt88US=>	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODd{OEGxNkc,OzB5MkixNVI9N2F-

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	DLK / p-MKK7 / MKK7 / p-JNK / JNK ; PubMed: 23431148 Proc Natl Acad Sci U S A Western blot of the DLK pathway members in RGCs (retinal ganglion cells) 4 h after immunopanning in the presence of 0, 0.03, 0.06, 0.125, 0.25, 0.5, 1, or 2 μM tozasertib. p-AURKA / AURKA / Survivin ; PubMed: 28218735 Oncogenesis BGC823 cells were incubated with indicated doses of VX-680 for 24 h before subjected to western blotting with the indicated antibodies. Densitometry was used to quantify the Survivin and GAPDH levels. The relative expression shown (right panel) are means±s.e.m. of the ratios of Survivin to GAPDH. YAP; PubMed: 31160567 Cell Death Dis Western blot analysis of YAP protein level in A549 cells treated with indicated doses of VX-680 for 24 h. p-AKT / p-GSK3β / Cleaved caspase-3 / Cleaved PARP ; PubMed: 21600017 J Transl Med NB4-R2 cells were collected, lysed and subjected to Western blot analysis with cleaved caspase-3, cleaved-PARP, pAkt-1 (Ser473), pGSK-3β (Ser9) specific antibodies. GAPDH was used as a loading control. Data shown is a representative of three independent experiments.	23431148 28218735 31160567 21600017
Immunofluorescence	α-tubulin / Aurora-A ; PubMed: 21600017 J Transl Med The morphology of mitotic spindle was shown by immunofluorescence staining with anti-α-tubulin antibody and anti-Aur-A antibodies. Microtubules were stained as green, Aur-A protein as red, and nucleus as blue.	21600017
Growth inhibition assay	Cell viability; PubMed: 21600017 J Transl Med VX-680 significantly suppresses the proliferation in a number of leukemic cell types. OCI-AML3, NB4, HL-60 and ML-1 cells were incubated with increasing doses of VX-680 (1, 2, 5 and 10 nM) for 24 hr. Cell viability was measured by MTT assay. Data summarized three independent experiments, p < 0.05, *p < 0.01, compared to control.	21600017

体内研究

VX-680作用于人类AML(HL-60)移植瘤模型明显降低肿瘤尺寸。VX-680按75 mg/kg剂量给药实验鼠,每天腹腔注射两次，持续13天,与对照组相比，平均肿瘤体积下降达98%。肿瘤体积比实验之前初始体积小很多。按12.5 mg/kg剂量每天给药两次，肿瘤生长也明显降低，这种作用存在剂量依赖性。VX-680耐受性很好，只有在使用高剂量时可以观察到实验动物体重稍微降低。通过比较cisplatin,按5.4 mg/kg剂量给药，每四天腹腔注射一次，一共进行三次，抑制肿瘤生长只达9%。VX-680作用于胰脏和结肠移植瘤，也引起肿瘤衰退。VX-680静脉注射给药携带HCT116肿瘤的实验鼠，显示很强的抗癌活性。使用高剂量VX-680(每小时2 mg/kg)处理，明显提高效果，比实验钱的初始肿瘤平均尺寸下降56%。^[1]

激酶实验： ^[3]	- 合并激酶抑制实验: 丙酮酸激酶/乳酸脱氢酶催化NADH的氧化，伴随着ATP的消耗，观察340 nm 处吸光值的降低。反应包括100 mM Tris (pH 为 8), 10 mM MgCl₂, 2.2 mM ATP, 1 mM磷酸烯醇丙酮酸, 0.6 mg/ml NADH, 75 ml丙酮酸激酶, 105 ml 乳酸脱氢酶,和0.5 mM 基底肽(序列为EAIYAAPFAKKK)。加入足够的激酶开始反应，反应的激酶浓度达到30 nM，用微量滴定板分光光度计在30^oC进行30分钟，观察吸收率的降低。通过加入3.75 μl 溶于100% DMSO的VX-680 或单独DMSO，获得抑制常数。按如下公式计算K_i值，K_i = IC50/(1+[S]/K_d),[S]=[ATP]=2.2 mM, K_d=70 μM。假定作用于野生型和H396P Abl 激酶域的K_d(ATP)为70 μM，计算以上各值。
细胞实验： ^[2]	- 合并 Cell lines: CAL-62细胞 Concentrations: 5-500 nM Incubation Time: 4天 Method: 对照组CAL-62细胞培养在二甲亚砜和DMSO中，实验组加入500 nM VX-680，处理1到5天。加入不同浓度(5到500 nM) Aurora抑制剂处理不同ATC细胞4天，用来测定VX-680作用于细胞增殖的剂量依赖性。细胞在温育结束前加30 mM BrdU标记，脉冲2小时。通过比色免疫分析使用细胞增殖ELISA试剂盒分析BrdU的合并率。通过比较VX-680处理的细胞和对照组细胞得到结果， (Only for Reference)
动物实验： ^[1]	- 合并 Animal Models: 右侧腋窝处皮下注射107 HL-60白血病细胞的雌性无胸腺NCr-nu鼠 Dosages: 50 mg/kg, 75 mg/kg Administration: 腹腔注射 (Only for Reference)

参考文献

[4] Cheetham GM, et al. Cancer Lett. 2007, 251(2), 323-329.

- 合并

溶解度 (25°C)

体外	DMSO	93 mg/mL (200.17 mM)
	Water	Insoluble
	Ethanol	Insoluble
体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： 5% DMSO+30% PEG 300+2% Tween 80+ddH2O	3.75 mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download Tozasertib (VX-680, MK-0457) SDF

分子量	464.59
化学式	C₂₃H₂₈N₈OS
CAS号	639089-54-6
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	N/A

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

临床试验信息 (data from https://clinicaltrials.gov, updated on 2021-09-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT00290550	Terminated	Drug: MK0457	Carcinoma Non-Small-Cell Lung	Merck Sharp & Dohme Corp.	June 2006	Phase 2
NCT00111683	Completed	Drug: MK0457	Chronic Myelogenous Leukemia in Blast Crisis\|Lymphocytic Leukemia B Cell Acute\|Myelodysplastic Syndromes\|Myelogenous Leukemia Chronic	Merck Sharp & Dohme Corp.	June 2005	Phase 1

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

Aurora Kinase Signaling Pathway Map

Aurora Kinase Inhibitors with Unique Features

泛Aurora Kinase抑制剂

Danusertib (PHA-739358) : Pan-Aurora kinase inhibitor, Aurora A/B/C, IC50=13 nM/79 nM/61 nM.
泛Aurora Kinase抑制剂

SNS-314 Mesylate : Pan-Aurora kinase inhibitor, Aurora A/B/C, IC50=9 nM/31 nM/3 nM.
活性最高的Aurora Kinase抑制剂

MK-5108 (VX-689) : Aurora A, IC50=0.064 nM.
用于临床的Aurora Kinase抑制剂

Alisertib (MLN8237) : Phase III for Relapsed/Refractory Peripheral T-Cell Lymphoma.
经典的Aurora Kinase抑制剂

Hesperadin : Potently inhibits Aurora B with IC50 of 250 nM.

研究领域

产品类型

定制您的化合物库

Tozasertib (VX-680, MK-0457)

客户使用Selleck生产的Tozasertib (VX-680, MK-0457)发表文献110篇：

产品安全说明书

Aurora Kinase抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download Tozasertib (VX-680, MK-0457) SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

临床试验信息 (data from https://clinicaltrials.gov, updated on 2021-09-06)

技术支持

Aurora Kinase Signaling Pathway Map

Aurora Kinase Inhibitors with Unique Features

相关Aurora Kinase产品