AZD8055

For research use only. Not for use in humans.

目录号：S1555

CAS No. 1009298-09-2

AZD8055是一种新型的，ATP竞争性mTOR抑制剂，在MDA-MB-468 细胞中IC50为0.8 nM，与作用于PI3K亚型和ATM/DNA-PK相比，具有优异的选择性（约1000倍）。AZD8055可诱导半胱天冬酶依赖的凋亡和自噬。Phase 1。

规格

价格

库存

购买数量

10mM (1mL in DMSO)	RMB 1265.49	现货
10mg	RMB 988.31	现货
50mg	RMB 3048.72	现货
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客户使用Selleck生产的AZD8055发表文献224篇：

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Nature, 2019, 10.1038/s41586-019-1607-3

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Nat Med, 2019, 25(5):838-849

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Cancer Cell, 2019, 35(5):752-766

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Cell, 2018, 172(1-2):373-386

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Cell Stem Cell, 2018, 22(3):369-383

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Nat Med, 2017, 23(2):200-212

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Cell Stem Cell, 2017, 20(2):177-190

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Cancer Cell, 2017, 31(5):635-652

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Nat Med, 2015, 10.1038/nm.3855

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Cancer Discov, 2015, 5(3):255-63

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Cancer Cell, 2015, 27(1):97-108

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Cancer Cell, 2015, 27(4):533-46

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Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7

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Metabolism, 2022, 130:155165

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Microbiol Spectr, 2022, 10(1):e0200721

PubMed: 35019705 ( click the link to review the publication )

Cancers (Basel), 2022, 14(6)1575

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Sci Adv, 2021, 7(40):eabj2485

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Nat Chem Biol, 2021, 10.1038/s41589-021-00751-4

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Nat Commun, 2021, 12(1):1589

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Nat Commun, 2021, 12(1):1920

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Cancer Res, 2021, 81(22):5652-5665

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Cell Rep, 2021, 34(11):108870

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Cell Rep, 2021, 35(1):108940

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Elife, 2021, 10e65962

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Haematologica, 2021, 10.3324/haematol.2021.278743

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Cell Death Dis, 2021, 12(11):1044

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Plant Physiol, 2021, kiab589

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J Clin Endocrinol Metab, 2021, dgab020

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Mol Cancer Ther, 2021, molcanther.0224.2021

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Front Cell Dev Biol, 2021, 9:662868

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Front Oncol, 2021, 11:648809

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Front Microbiol, 2021, 12:596874

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J Biol Chem, 2021, S0021-9258(21)00418-X

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J Pharm Biomed Anal, 2021, 208:114436

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Arch Pharm Res, 2021, 10.1007/s12272-021-01358-y

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Oncol Lett, 2021, 21(4):269

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Biomed Chromatogr, 2021, e5190

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STAR Protoc, 2021, 2(1):100300

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Nat Commun, 2020, 11(1):4684

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Dev Cell, 2020, 55(3):298-313.e10

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Clin Cancer Res, 2020, 10.1158/1078-0432

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Cell Rep, 2020, 31(12):107810

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J Bone Miner Res, 2020, 10.1002/jbmr.4176

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Br J Cancer, 2020, 22

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Front Immunol, 2020, 11:572960

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Mol Cancer Ther, 2020, 5;molcanther.1131.2019

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Mol Cancer Ther, 2020, 19(3):882-894

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Aging (Albany NY), 2020, 12(19):19022-19044

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J Cancer, 2020, 15;11(12):3492-3501

PubMed: 32284745 ( click the link to review the publication )

J Cell Sci, 2020, 133(14)jcs246306

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Sci Rep, 2020, 4;10(1):4025

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J Biol Chem, 2020, 22;295(21):7418-7430

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Cell Cycle, 2020, 1-15

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Biosci Rep, 2020, 30;40(4):BSR20200905

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Biochem Biophys Res Commun, 2020, 23;S0006-291X(20)30951-7

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G3 (Bethesda), 2020, 4;10(5):1585-1597

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Kaohsiung J Med Sci, 2020, 10.1002/kjm2.12319

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Nat Commun, 2020, 11(1):3627

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BMC Cancer, 2020, 20(1):724

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Nat Med, 2020, 10.1038/s41591-020-0986-1

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J Cell Biol, 2020, 219(2)

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J Invest Dermatol, 2020, S0022-202X(20)31981-3

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Int Immunopharmacol, 2020, 81:106241

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Cell Rep, 2020, 32(3):107933

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Mol Oncol, 2020, 10.1002/1878-0261.12673

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Cancer, 2020, 10.1002/cncr.33071

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Mol Cell, 2019, 10.1016/j.molcel.2019.10.016

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Autophagy, 2019, 10.1080/15548627.2019.1660545

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Autophagy, 2019, 15(3):543-557

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Clin Cancer Res, 2019, 25(21):6429-6442

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Clin Cancer Res, 2019, 25(16):5107-5121

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Curr Biol, 2019, 29(5):737-749

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Cell Rep, 2019, 27(12):3696-3708.e5

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Sci Signal, 2019, 12(612)

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Cancers (Basel), 2019, 11(10)

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J Neurosci, 2019, 39(27):5255-5268

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Cell Death Dis, 2019, 10(8):563

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Cell Chem Biol, 2019, 26(3):366-377

PubMed: 30661989 ( click the link to review the publication )

Curr Biol, 2019, 29(5):737-749

PubMed: 30773367 ( click the link to review the publication )

Am J Cancer Res, 2019, 9(9):1922-1937

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Sci Rep, 2019, 9(1):30

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Sci Rep, 2019, 9(1):9805

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Cancer Gene Ther, 2019, 10.1038/s41417-019-0117-7

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Biochem J, 2019, 476(20):3081-3107

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Front Physiol, 2019, 10:167

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Biomed Res Int, 2019, 2019:5196028

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JCI Insight, 2019, 4(20)124164

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Cell Mol Gastroenterol Hepatol, 2019, 8(1):21-36

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Cancer Biol Med, 2019, 16(1):66-83

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Nat Cell Biol, 2018, 20(4):465-478

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Cancer Res, 2018, 78(12):3176-3189

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Cancer Res, 2018, 78(15):4396-4410

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Cell Death Dis, 2018, 9(11):1063

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J Mol Cell Biol, 2018, 10(4):331-340

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Sci Rep, 2018, 8(1):10784

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Acta Pharmacol Sin, 2018, 39(8):1338-1346

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Front Genet, 2018, 9:690

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Cell Signal, 2018, 44:127-137

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PLoS One, 2018, 13(8):e0200725

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Med Sci Monit, 2018, 24:2735-2743

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Oncol Lett, 2018, 16(4):4561-4566

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J Exp Med, 2018, 215(1):159-175

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Oncol Lett, 2018, 16(1):632-642

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Nat Commun, 2017, 8(1):1090

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Nat Commun, 2017, 8(1):2207

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Nucleic Acids Res, 2017, 45(16):9654-9678

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Cell Syst, 2017,

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Mol Syst Biol, 2017, 13(1):905

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Cell Rep, 2017, 20(10):2341-2356

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Oncogene, 2017, 36(15):2074-2084

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Oncogene, 2017, 36(26):3651-3660

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Sci Signal, 2017, 10(507)eaam7550

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PLoS Pathog, 2017, 13(4):e1006344

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Cell Commun Signal, 2017, 10.1186/s12964-017-0164-3

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Biochim Biophys Acta Mol Cell Res, 2017, 1864(10):1554-1565

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Sci Rep, 2017, 7(1):1994

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Sci Rep, 2017, 7(1):1535

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J Pharm Biomed Anal, 2017, 145:473-481

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PLoS One, 2017, 12(7):e0181243

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Anticancer Res, 2017, 37(3):1083-1090

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Oncotarget, 2017, 8(4):5992-6002

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Oncotarget, 2017, 8(1):979-987

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Oncotarget, 2017, 8(25):41422-41431

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Nat Cell Biol, 2016, 18(5):527-39

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Genome Biol, 2016, 17(1):149

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Nat Chem Biol, 2016, 12(1):22-8

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EMBO J, 2016, 35(17):1902-22

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Mol Oncol, 2016, 10(1):101-12

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Mol Oncol, 2016, 10(4):538-52

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Aging (Albany NY), 2016, 8(2):231-44

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Aging (Albany NY), 2016, 8(12):3535-3551

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J Immunol, 2016, 196(10):4390-9

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Sci Rep, 2016,

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J Biol Chem, 2016, 291(12):6262-71

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Front Plant Sci, 2016, 7:1746

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Cell Signal, 2016, 28(4):284-93

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PLoS One, 2016, 11(4):e0154564

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Biochem Biophys Res Commun, 2016, 478(4):1515-20

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Int J Endocrinol, 2016, 2016:5286972

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Oncotarget, 2016, 7(44):71211-71222

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Oncotarget, 2016, 7(4):3947-65

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Autophagy, 2015, 11(2):285-97

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Cancer Res, 2015, 75(20):4398-406

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Cell Rep, 2015, 11(3):446-59

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J Hematol Oncol, 2015,

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Sci Signal, 2015, 8(375):ra42

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J Med Chem, 2015, 58(16):6559-73

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Cancer Discov, 2015, 5(3):255-63

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Cancer Discov, 2015, 5(3):245-54

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Clin Sci, 2015, 128(8):517-26

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J Cancer, 2015, 6(12):1195-205

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Mol Cancer Res, 2015, 13(2):223-30

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Mol Cancer Res, 2015, 13(1):120-9

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Mol Cancer Res, 2015, 13(1):120-9

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Mol Cancer Res, 2015, 13(2):223-30

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Int J Mol Sci, 2015, 16(2):3267-82

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Am J Physiol Endocrinol Metab, 2015, 309(2):E142-53

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J Biol Chem, 2015, 10.1074/jbc.C114.627778

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Stem Cells Int, 2015, 2015:561404

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Biochem J, 2015, 465(2):227-38

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J Chromatogr A, 2015, 1388:267-73

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J Chromatogr A, 2015, 1388:267-73

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Proteomics, 2015, 10.1002/pmic.201400586

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Cell Signal, 2015, 27(8):1557-68

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Cancer Biol Ther, 2015,

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PLoS One, 2015, 10(11):e0143357

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PLoS One, 2015, 10(7):e0131400

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Oncotarget, 2015, 6(11):8722-35

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Clin Sci (Lond), 2015, 128(8):517-26

PubMed: 25428582 ( click the link to review the publication )

Oncotarget, 2015, 6(7):5118-33

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Cell Signal, 2015, 27(11):2191-200

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J Clin Invest, 2014, 10.1172/JCI73935

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Nat Commun, 2014, 5:3384

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Autophagy, 2014, 10(6):1120-36

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Leukemia, 2014, 28(5):1092-102

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Cancer Res, 2014, 74(10):2846-56

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Cancer Res, 2014, 74(14):3947-58

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Clin Cancer Res, 2014, 20(22):5756-67

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Int J Cancer, 2014, 10.1002/ijc.28880

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Antioxid Redox Sign, 2014, 20(9):1382-95

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Sci Signal, 2014, 7(349):ra102

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Mol Metab, 2014, 3(6):630-41

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Mol Cell Proteomics, 2014, 13(6):1429-38

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Am J Cancer Res, 2014,

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Am J Cancer Res, 2014, 4(6):824-837

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Biochem J, 2014, 463(3):413-27

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Mol Cell Biol, 2014, 34(22):4088-103

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Mol Cell Biol, 2014, 34(13):2517-32

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Mol Reprod Dev, 2014, 81(7):655-65

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Oncol Rep, 2014, 31(2):649-56

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PLoS One, 2014, 9(12):e113555

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Oncotarget, 2014,

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Oncotarget, 2014, 5(21):10732-44

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Oncotarget, 2014, 5(21):10503-17

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Oncotarget, 2014, 5(15):6015-27

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Oncotarget, 2014, 5(18):8737-49

PubMed: 25228590 ( click the link to review the publication )

Blood, 2013, 121(18):3619-30

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EMBO J, 2013, 28;32(17):2377-91

PubMed: 23921550 ( click the link to review the publication )

Cancer Res, 2013, 73(11):3402-11

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Mol Cancer, 2013, 12:81

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Am J Transplant, 2013, 13(8):2035-43

PubMed: 23841834 ( click the link to review the publication )

Sci Signal, 2013, 6(271):ra25

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Mol Cancer Ther, 2013, 13(1):37-48

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Mol Cancer Ther, 2013,

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Mol Oncol, 2013, 33:404-18

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J Hypertens, 2013, 31(2):303-11

PubMed: 23303355 ( click the link to review the publication )

J Biol Chem, 2013, 288(49):35287-96

PubMed: 24133218 ( click the link to review the publication )

Mol Biol Cell, 2013, 24(23):3736-45

PubMed: 24088573 ( click the link to review the publication )
Cancer Chemother Pharmacol, 2013, 71(5):1297-307

PubMed: 23479136 ( click the link to review the publication )

PLoS One, 2013, 8(2):e56567

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Onco Targets Ther, 2013, 6:1373-84

PubMed: 24124380 ( click the link to review the publication )

Biochem Biophys Res Commun, 2013, 440(4):701-6

PubMed: 24103749 ( click the link to review the publication )

Oncol Lett, 2013, 5(2):717-721

PubMed: 23420667 ( click the link to review the publication )

Autophagy, 2012, 9(1):74-92

PubMed: 23196898 ( click the link to review the publication )

Exp Neurol, 2012, 233(2):799-806

PubMed: 22177999 ( click the link to review the publication )

Biochem Pharmacol, 2012, 83(9):1183-94

PubMed: 22305748 ( click the link to review the publication )

产品安全说明书

mTOR抑制剂选择性比较

生物活性

产品描述

特性

AZD8055是第一种抑制两种类型mTOR蛋白的药物，被认为可能比之前mTOR抑制剂更有效。

靶点

mTOR (truncated) ^[1] (MDA-MB-468 cells)	mTOR (full length) ^[1] (MDA-MB-468 cells)
0.13 nM	0.8 nM

体外研究

AZD8055作用于所有 PI3K亚型 (α, β, γ, δ) 和其他近PI3K激酶家族(ATM和DNA-PK)显示出低活性。AZD8055抑制mTORC1(p70S6K 和4E-BP1) ，mTORC2 (AKT) 和下游蛋白的磷酸化。AZD8055完全抑制4E-BP1抗Rapamycin 的T37/46 磷酸化位点, 导致明显抑制cap-dependent 转译作用。AZD8055有效抑制U87MG, A549和H838 细胞增殖， IC50分别为53, 50，和20 nM。AZD8055作用于H838和A549细胞，也诱导自体吞噬和增加LC3-II 水平。^[1] AZD8055降低白血病细胞增殖和细胞周期进展, 降低白血病祖细胞的无性系生长，且在白血病细胞中诱导caspase依赖的细胞凋亡，但是作用于正常未成熟的CD34+ 细胞时不会产生这种诱导作用。^[2] AZD8055 抑制儿科临床前期测试计划(PPTP)细胞系，IC50 为24.7 nM，且在EFS 分布时诱导产生明显区别。^[3]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
LU-139	M4fEVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NX\RRnVKUUN3ME2wMlAzOzNzIN88US=>	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
NCI-H720	M3fm[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYPJR\|UxRTBwMEK5N\|gh\|ryP	NEjkVnM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
KARPAS-45	NEO0Z4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MYTJR\|UxRTBwMEOzO\|Eh\|ryP	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
EW-3	NXjNepNwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXnJR\|UxRTBwMESwOVYh\|ryP	NFPrcoE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
SBC-1	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Mm\4TWM2OD1yLkC0OVgyKM7:TR?=	M3;IbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
NCI-H209	M1\mSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MkXvTWM2OD1yLkC1OFU{KM7:TR?=	MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
EoL-1-cell	NWjzbZRyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MmXRTWM2OD1yLkC2OVY6KM7:TR?=	M4DIPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
H9	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MoTYTWM2OD1yLkC2OlkzKM7:TR?=	M1PublxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
AN3-CA	M331VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MUPJR\|UxRTBwMEe5OVEh\|ryP	NXLjWIdURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
HH	NF20OGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MkHITWM2OD1yLkC4NFA6KM7:TR?=	M3jCW\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
KU812	NVzaSlE3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1rNTGlEPTB;MD6wPFA1OyEQvF2=	MkDiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
DU-4475	M3HGR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mo\3TWM2OD1yLkC4NFQ4KM7:TR?=	NWPORlhXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
CTV-1	NUK3XWs1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MYfJR\|UxRTBwMEi2OFEh\|ryP	NY[zXpBORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
BV-173	M4rNcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M3u4UGlEPTB;MD6wPVA3OSEQvF2=	NVyy[FFyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
ES5	M2qweGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MlL2TWM2OD1yLkC5N\|Uh\|ryP	MlntQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
G-402	MmD2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1\pUWlEPTB;MD6wPVk5KM7:TR?=	NGfPe\|M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
MV-4-11	NVjJdlNCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnvzTWM2OD1yLkGwN\|Q4KM7:TR?=	MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
NB69	NXTLcZpNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXrJR\|UxRTBwMUO1JO69VQ>?	Ml7lQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
EGI-1	MonrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGL5dFVKSzVyPUCuNVM2OzFizszN	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
EW-18	Mln0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MWfJR\|UxRTBwMUSwO\|Mh\|ryP	NUT0eYZtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
ME-180	MlXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2O0U2lEPTB;MD6xOFY5OSEQvF2=	NYHLR3d7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
D-283MED	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NXrBRWJtUUN3ME2wMlE1PzJ\|IN88US=>	NVKwR\|Y6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
NB14	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUjJR\|UxRTBwMU[0OFch\|ryP	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
Ramos-2G6-4C10	NYizUYRJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnvkTWM2OD1yLkG2PVg{KM7:TR?=	NHvMSpQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
NBsusSR	NGThUpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NGPBdGNKSzVyPUCuNVcxOTlizszN	NFPOdZE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
LAMA-84	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{D0RmlEPTB;MD6xPFA{OiEQvF2=	NUe1WolQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
NCI-H1581	MmDuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NEG0SpZKSzVyPUCuNVg6PjZizszN	MlfHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
A204	NH\oRY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NIrnWFZKSzVyPUCuNVg6PyEQvF2=	MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
A549	NFjHZ3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NIDWTmVKSzVyPUCuNVk2PSEQvF2=	MkL2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
CAL-51	NVvTbWpOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MmXYTWM2OD1yLkG5OlUyKM7:TR?=	NXnlPFBCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
NKM-1	NH\KSm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NYXpcJg5UUN3ME2wMlIxODJ7IN88US=>	NITReok9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
LoVo	NF;hb\|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NYjwWVZyUUN3ME2wMlIxOjB{IN88US=>	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
HAL-01	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MojSTWM2OD1yLkKwNlk4KM7:TR?=	Mmr6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
HCC2218	NXj3SWVnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NX\pTHV1UUN3ME2wMlIxPjh6IN88US=>	MlviQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
BEN	NVroc2dNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MmLBTWM2OD1yLkKxNlk{KM7:TR?=	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
LC-2-ad	MmnlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlHQTWM2OD1yLkKyNFg1KM7:TR?=	NEjoZlI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
LXF-289	MojoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MUHJR\|UxRTBwMkWwOFEh\|ryP	NXjvb5pERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
HGC-27	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Mn7RTWM2OD1yLkK2OFE1KM7:TR?=	M1fpbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
LK-2	M4XZbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M32weGlEPTB;MD6yOlgzPCEQvF2=	MlP5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
CTB-1	NVe4fmdWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NFrtbFlKSzVyPUCuNlczOTVizszN	M1HCPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
697	M3vWdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYDJR\|UxRTBwMkezOlch\|ryP	MnXFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
ES7	NEnNXnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NH;uT4ZKSzVyPUCuNlc{QDNizszN	M2n1eFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
MG-63	M{i2PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVvJR\|UxRTBwMke0NFch\|ryP	NX;KfpgyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
T47D	MlTVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MmPNTWM2OD1yLkK3OFc2KM7:TR?=	MnzSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
RPMI-8226	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnjRTWM2OD1yLkK4OVg6KM7:TR?=	MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
NCI-H292	NX32NFhNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NYDkRohxUUN3ME2wMlI6OTZ2IN88US=>	NEHHPHM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
HT	MknsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NF76[o9KSzVyPUCuNlk{QCEQvF2=	NVrZcVY6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
A3-KAW	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MX\JR\|UxRTBwMkm3OEDPxE1?	MnrMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
LB2241-RCC	NFHFNXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NEXQO2tKSzVyPUCuN\|AyQThizszN	Mnu0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
BB65-RCC	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NUfENW0xUUN3ME2wMlMxQDB3IN88US=>	NXPiU3pyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
G-401	NGnkUotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4X5dmlEPTB;MD6zNFk5PiEQvF2=	NFHrRW89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
TYK-nu	M4\iO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NXjvO4V6UUN3ME2wMlMyQDZ2IN88US=>	NYnXWnd[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
NCI-SNU-1	NI[ycHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NIjiT\|ZKSzVyPUCuN\|I{OzFizszN	M3nYbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
CHL-1	MnfDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHnCb\|JKSzVyPUCuN\|I4ODNizszN	M4XTTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
P30-OHK	MkX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M13G[WlEPTB;MD6zNlcxPSEQvF2=	Ml\WQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
PA-1	M2LXfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MX;JR\|UxRTBwM{O2NVkh\|ryP	M{nkWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
LB1047-RCC	MnOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M4i3WGlEPTB;MD6zOFA1PyEQvF2=	NX7oSog6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
EM-2	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVPJR\|UxRTBwM{SxPFgh\|ryP	NVn5e5h3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
VA-ES-BJ	Ml7LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGTnV2pKSzVyPUCuN\|QzPjhizszN	NYrTc\|M6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
NCI-H520	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NH71d3hKSzVyPUCuN\|Q5OzRizszN	Mlm5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
ECC10	NXi2WGk5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MorOTWM2OD1yLkO1NFM2KM7:TR?=	NXnvWGFQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
LNCaP-Clone-FGC	NHm1NYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWLJR\|UxRTBwM{WzNVQh\|ryP	Mkj2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
ES8	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NGnLOnRKSzVyPUCuN\|Y2PTNizszN	NVTRclNpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
HuO-3N1	M3ixdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MV7JR\|UxRTBwM{izO\|kh\|ryP	M4W4VlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
L-363	NVz2Om9VT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NX3MNZJRUUN3ME2wMlM6ODJ4IN88US=>	M4fC[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
SK-LU-1	M3P0dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVPWN2ZQUUN3ME2wMlM6OjB6IN88US=>	NVfnN4dDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
MCF7	M1rDSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MmjKTWM2OD1yLkSwOVMh\|ryP	NXXFTJdjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
HuO9	NX70d4VOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MmX5TWM2OD1yLkSwOlY4KM7:TR?=	NH7HPGc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
BHT-101	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MXvJR\|UxRTBwNEC3PFch\|ryP	MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
MZ2-MEL	MoTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYTJR\|UxRTBwNEC4PFIh\|ryP	NVz3O5ltRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
NOS-1	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3T0SWlEPTB;MD60NVA4PCEQvF2=	MljwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
NEC8	Mm[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NI\adZlKSzVyPUCuOFE3QTVizszN	M4e1fVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
COR-L88	MmL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NIrqd5VKSzVyPUCuOFIzPjdizszN	M4XqbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
MFM-223	NHjCTmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NGK2W49KSzVyPUCuOFI3OTdizszN	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
HSC-3	NIroVoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUG4bXpIUUN3ME2wMlQzQTB6IN88US=>	NF;0XYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
OVCAR-5	NGHsNG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Ml;mTWM2OD1yLkSyPVM{KM7:TR?=	NVPTTpc3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
MFE-280	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MXPJR\|UxRTBwNEOwN\|Ih\|ryP	NIXxZWM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
KP-N-YS	M2\J[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVfqSmhwUUN3ME2wMlQ{ODdizszN	M1u2RVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
EPLC-272H	NFLSNVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4WxO2lEPTB;MD60N\|A4PyEQvF2=	NYrQeo53RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
KE-37	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWfJNWUxUUN3ME2wMlQ{OjR5IN88US=>	NF\OTGY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
HuH-7	M4LxdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MmnsTWM2OD1yLkSzN\|czKM7:TR?=	NXjEUYY3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
CHP-212	NUjsZoxZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1\XOWlEPTB;MD60N\|Y6PyEQvF2=	NX36N5pHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
SK-MES-1	NFPsbYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3TRSGlEPTB;MD60N\|g1QCEQvF2=	NX7pNXc2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
SJSA-1	M1HXW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NEXVU\|RKSzVyPUCuOFQ2PTRizszN	M2rFfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
QIMR-WIL	NX3EO\|E2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{HLdmlEPTB;MD60OVE2KM7:TR?=	Mn;aQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
ES4	NYPLPVdrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MULJR\|UxRTBwNEWzN\|Yh\|ryP	NVHNdWtqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
TI-73	NEX3RVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXzYb3JEUUN3ME2wMlQ2Pjh4IN88US=>	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
COLO-684	MnfNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MX\JR\|UxRTBwNEW3NlYh\|ryP	MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
GCIY	M3PMZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4fIXGlEPTB;MD60OVc2PCEQvF2=	M4ns[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
JVM-3	Mke1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3WwUmlEPTB;MD60OlI6OiEQvF2=	MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
MPP-89	NEXHOpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NH;4PIxKSzVyPUCuOFY6PDdizszN	NICzZ3U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
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HCC1569	M3vkV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NInHWphKSzVyPUCuPFUzODdizszN	MmHZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
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U87-MG	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		Ml;ZO\|IhcA>?		M1PvXGdKPTEkgJm95qCKPzlibl5CpC=>	NH;tZ5k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEK0PVY1OCd-MkSyOFk3PDB:L3G+
L3.6pl	MkXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MW[xJO69VQ>?	M13BWVczKGh?		MmjUbY5pcWKrdIOgeIhmKGOnbHyg[5Jwf3SqIHPvcYJqdmWmIIfpeIghSk2VLUe3O\|YxPw>?	NFfwcng9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEKzN\|M6QSd-MkSyN\|M{QTl:L3G+
TE671	NFG2VHVCeG:ydH;zbZMhSXO\|YYm=	MVyxJO69VQ>?	Ml3jOFghcA>?		M3Pkcolv[3KnYYPld{Bk\WyuIHHwc5B1d3OrczDpcoR2[2WmIHL5JGFDXC15M{e=	NIrGUGQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEGzN\|IyQCd-MkSxN\|MzOTh:L3G+
RD	NG[1SZFCeG:ydH;zbZMhSXO\|YYm=	NIT6[4oyKM7:TR?=	M3XjdlQ5KGh?		MXrpcoNz\WG\|ZYOgZ4VtdCCjcH;weI9{cXNiaX7keYNm\CCkeTDBRnQuPzN5	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDF\|M{KxPEc,OjRzM{OyNVg9N2F-
RMS13	M1nibmFxd3C2b4Ppd{BCe3OjeR?=	MmHaNUDPxE1?	M3rJelQ5KGh?		MV\pcoNz\WG\|ZYOgZ4VtdCCjcH;weI9{cXNiaX7keYNm\CCkeTDBRnQuPzN5	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDF\|M{KxPEc,OjRzM{OyNVg9N2F-
RH30	NGLyeYFCeG:ydH;zbZMhSXO\|YYm=	M4mySlEh\|ryP	MkHtOFghcA>?		NHjjdWJqdmO{ZXHz[ZMh[2WubDDhdI9xfG:\|aYOgbY5lfWOnZDDifUBCSlRvN{O3	MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDF\|M{KxPEc,OjRzM{OyNVg9N2F-
Hep-2	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NV;R[2dIOC5yMT2xJO69VQ>?	MVmxNk06PiCq		M4exOolv[3KnYYPld{Bk\WyuIHTlZZRpKGmwIHGgZ49v[2WwdILheIlwdi1iYX7kJJRqdWVvZHXw[Y5l\W62IH3hco5meg>?	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDFyM{e0PUc,OjRzMEO3OFk9N2F-
SCC-9	MkHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVj1dWlLOC5yMT2xJO69VQ>?	M4XiRlEzNTl4IHi=		M2P0Solv[3KnYYPld{Bk\WyuIHTlZZRpKGmwIHGgZ49v[2WwdILheIlwdi1iYX7kJJRqdWVvZHXw[Y5l\W62IH3hco5meg>?	M4PlNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUCzO\|Q6Lz5{NEGwN\|c1QTxxYU6=
Hep-2	M2fOT2Z2dmO2aX;uJGF{e2G7	NHXlXmYxNjFxMD61JO69VQ>?	MnnlNlQhcA>?		NVnXNnZM[myxY3vzJI1VV1KFMTDhcoQhdVSRUlOyJIFkfGm4YYTpc44>	M{DDZ\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUCzO\|Q6Lz5{NEGwN\|c1QTxxYU6=
SCC-9	NFXaW4FHfW6ldHnvckBCe3OjeR?=	M2CwT\|AvOS9yLkWg{txO	M{nINVI1KGh?		MlvrZoxw[2u\|IH3UU3JEOSCjbnSgcXRQWkN{IHHjeIl3[XSrb36=	M2myeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUCzO\|Q6Lz5{NEGwN\|c1QTxxYU6=
PANC-1	MoiwRZBweHSxc3nzJGF{e2G7	NHTiUFQ2ODBibl2=	M2jDdFQ5KGh?		NInxUFB{\W6\|aYTpfoV{KHCjbnPy[YF1cWNiY3HuZ4VzKGOnbHzzJJRwKHKjZHnveIhmemGyeR?=	MlLBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6OE[yPVQoRjJ\|OEi2Nlk1RC:jPh?=
RMG2	MmjmRZBweHSxc3nzJGF{e2G7	NELEUIIyNTFyMECgcm0>	MYe3NkBp	NWjNfolkTkKV	NGLGO5NqdmirYnn0d{B1cGViY3XscEB3cWGkaXzpeJkh[2:wY3XueJJifGmxbjDk[ZBmdmSnboTsfS=>	Ml3MQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MUW2N\|EoRjJ\|NkG1OlMyRC:jPh?=
HAC2	NEewNWJCeG:ydH;zbZMhSXO\|YYm=	NUHzdHZDOS1zMECwJI5O	NEPhXJM4OiCq	NGSxSFBHSlN?	NGXZOIpqdmirYnn0d{B1cGViY3XscEB3cWGkaXzpeJkh[2:wY3XueJJifGmxbjDk[ZBmdmSnboTsfS=>	NF:2[lg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[xOVY{OSd-MkO2NVU3OzF:L3G+
HT-29	NGnx[GRCeG:ydH;zbZMhSXO\|YYm=	NHXZfWwyKM7:TR?=	MUe3NkBp		M3\ZfYF1fGWwdXH0[ZMhPS2IVT3pcoR2[2WmIHPlcIwh\GWjdHi=	MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl2OUGyNUc,OjF7NEmxNlE9N2F-
DLD1	NEf0RZdCeG:ydH;zbZMhSXO\|YYm=	MknVNUDPxE1?	NVHTO5RxPzJiaB?=		M{DLb4F1fGWwdXH0[ZMhPS2IVT3pcoR2[2WmIHPlcIwh\GWjdHi=	Mm[4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NEmxNlEoRjJzOUS5NVIyRC:jPh?=
HT-29	NWPCO4lpTnWwY4Tpc44hSXO\|YYm=	M2HRXVEh\|ryP	NELnO2Q4OiCq		NHfHVGdqdmS3Y3XzJIF2fG:yaHHnfUB1dyClb37m[ZIh[3m2b4Dyc5Rm[3Srb36=	MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl2OUGyNUc,OjF7NEmxNlE9N2F-
DLD1	NInWVYxHfW6ldHnvckBCe3OjeR?=	NVXTNmdWOSEQvF2=	MYW3NkBp		M2S3W4lv\HWlZYOgZZV1d3CqYXf5JJRwKGOxbn\ldkBkgXSxcILveIVkfGmxbh?=	MmfIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NEmxNlEoRjJzOUS5NVIyRC:jPh?=
Rh41	NFjENlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVvJR\|UxRTNyLkegcm0>	M1nLdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzM{O3Olc6Lz5{MUOzO\|Y4QTxxYU6=
Rh18	M{\BOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MX;JR\|UxRTRzLkSgcm0>	NEnKVms9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUOzO\|Y4QSd-MkGzN\|c3Pzl:L3G+
Rh30	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVPJR\|UxRTF2IH7N	NIHCOFM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUOzO\|Y4QSd-MkGzN\|c3Pzl:L3G+
BT-12	NF;1cGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUfiZWRZUUN3ME2yOE44KG6P	MnLrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF\|M{e2O\|koRjJzM{O3Olc6RC:jPh?=
CHLA-266	NG\wS\|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVPNVXVLUUN3ME2xMlEhdk1?	MnG1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF\|M{e2O\|koRjJzM{O3Olc6RC:jPh?=
TC-71	MoS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MoC2TWM2OD12Nj61JI5O	NFzNSXE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUOzO\|Y4QSd-MkGzN\|c3Pzl:L3G+
CHLA-9	NV3jNnVyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MVLJR\|UxRTF3LkOgcm0>	NV\KU4hCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzN\|c3PzlpPkKxN\|M4Pjd7PD;hQi=>
CHLA-10	Mke1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MoLnTWM2OD1\|Lkmgcm0>	NFHBPZc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUOzO\|Y4QSd-MkGzN\|c3Pzl:L3G+
CHLA-258	NUXHcFNXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MV7JR\|UxRTFyLkSgcm0>	MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTN\|N{[3PUc,OjF\|M{e2O\|k9N2F-
GBM2	NYW4c4d7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MU\JR\|UxRTRyLkegcm0>	M4LmZ\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzM{O3Olc6Lz5{MUOzO\|Y4QTxxYU6=
NB-1643	NHPoVVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NED1NWtKSzVyPUOzMlghdk1?	NXfpW5h7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzN\|c3PzlpPkKxN\|M4Pjd7PD;hQi=>
NB-EBc1	Ml\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NY\Me\|Q3UUN3ME2yO{4yKG6P	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTN\|N{[3PUc,OjF\|M{e2O\|k9N2F-
CHLA-90	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2\oTmlEPTB;M{SuOUBvVQ>?	NYfpWYh5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzN\|c3PzlpPkKxN\|M4Pjd7PD;hQi=>
CHLA-136	NVn1UGxMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mm\STWM2OD1zNkKuOkBvVQ>?	NFjFZYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUOzO\|Y4QSd-MkGzN\|c3Pzl:L3G+
NALM-6	MlTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1rCOWlEPTB;M{KuPUBvVQ>?	NVuz[\|FYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzN\|c3PzlpPkKxN\|M4Pjd7PD;hQi=>
COG-LL-317	NI[zUGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Ml\GTWM2OD1zLkOgcm0>	NGKySnA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUOzO\|Y4QSd-MkGzN\|c3Pzl:L3G+
RS4;11	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4TaWGlEPTB;M{Wgcm0>	NFXQT4c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUOzO\|Y4QSd-MkGzN\|c3Pzl:L3G+
MOLT-4	Ml\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M33EdmlEPTB;OD62JI5O	M4PY[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzM{O3Olc6Lz5{MUOzO\|Y4QTxxYU6=
CCRF-CEM	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmLHTWM2OD12LkGgcm0>	M1fuUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzM{O3Olc6Lz5{MUOzO\|Y4QTxxYU6=
Kasumi-1	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2fQdmlEPTB;MT60JI5O	NXj4VmtKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzN\|c3PzlpPkKxN\|M4Pjd7PD;hQi=>
Karpas-299	M4TaPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4HvZ2lEPTB;MkGuO{BvVQ>?	MkHuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF\|M{e2O\|koRjJzM{O3Olc6RC:jPh?=
Ramos-RA1	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2[zWWlEPTB;OD6yJI5O	NH7yVXA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUOzO\|Y4QSd-MkGzN\|c3Pzl:L3G+
H838	MUnGeY5kfGmxbjDBd5NigQ>?	NGXxNZEyKM7:TR?=	M4XJflQ5KGh?		NY\yd3FMcW6mdXPld{Bk\WyuIHH1eI9xcGGpeR?=	NX7JbFl6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzOlQyOTNpPkKwN\|Y1OTF\|PD;hQi=>
H838	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MX2wMVMh\|ryP	Mnq1O\|IhcA>?		MU\pcoR2[2W\|IHfyc5d1cCCrbnjpZol1cW:wIHHu[EBifXSxcHjh[5k>	M37oRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMEK4PFU1Lz5{MECyPFg2PDxxYU6=
A549	Mlu0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4OzZVAuOyEQvF2=	MVK3NkBp		MVjpcoR2[2W\|IHfyc5d1cCCrbnjpZol1cW:wIHHu[EBifXSxcHjh[5k>	NEnZVGc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MECyPFg2PCd-MkCwNlg5PTR:L3G+

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-mTOR / p-AKT / p-4EBP1 / p-P70S6K / p-PRAS40; PubMed: 24457069 Breast Cancer Res Western blots of 70% confluent TamR (A) and MCF7-X (B) cells treated for 15 minutes to 24 hours with AZD8055 (0 to 100 nM). Blots were probed with phospho- and total antibodies for mTORC1 and two signalling pathways. In both cell lines mTORC1 and mTORC2 s䲧疝Ỵ疞㧀疜膉痘瘿삨ՂᾰƌՂĀ㺣痖帉痖Ѐ瑖堘𢡄빢᎒ՂĀ鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙 p-EGFR / EGFR; PubMed: 25654224 Int J Mol Sci PANC-1 cells were treated with AZD8055 for the indicated hours and EGFR (T/P), AKT (T/P) and ribosomal protein S6 (S6) (T/P) proteins were examined by western-blot; p-FOXO1 / FOXO1 / p-FOXO3a / FOXO3a ; PubMed: 25654224 Int J Mol Sci PANC-1 cells were transfected with FoxO1/FoxO3a siRNAs and treated with AZD8055 for 1 h, then AKT (T/P), FoxO1 (T/P), FoxO3a (T/P) and EGFR (T/P) proteins were examined by western-blot.	24457069 25654224
Immunofluorescence	p-4EBP1 / EIF4E / mTOR; PubMed: 24600487 Int J Clin Exp Med (C) Hoechst 33258 staining of Hep-2 cells after treatment with AZD8055 for 24 hours were shown. The cells were fixed and immunereacted with anti-mTOR antibody followed by incubation with Alexa 488-labeled secondary antibody (C-F). Images were taken by a c䲧疝Ỵ疞㧀疜膉痘瘿삨ՂᾰƌՂĀ㺣痖帉痖Ѐ瑖堘𢡄빢᎒ՂĀ鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ�෋䐺痖暼瘿�෋ᾰƌ �෋à㺣痖�෋𢡄�෋䀷痗�෋౴�෋㵶痗�෋뺖᎒泌Itemｾ᎒Count﫨呂�෋猴፲�෋፲씢痗猸፲髸莤䥷堙᎒ｾ᎒�堞ﻮ᎒፲露𢡄堚،齃礤v�堞ﻮ᎒猢Wｾ᎒䨼Ą鹿齃殺獸W戀醙玛W戀ⶰ໯齃礤v玚W玢Wⶰ໯﫰礌vtЉᔈැ鲬౴᥊疜犈፲Eo狜፲艘ᎂ艘ᎂ⩈̎䥠̌씢痗狠፲붖᎒i變ﱘ﫰﬐먙堘붖᎒狠፲i變ﱘ﫰먰堘ﱘ붖᎒�堞봆᎒릎堘붖᎒i꣩쯟巰痗ꣵ쯟巰痗Љ镴౴嶴痗Љ镨౴ᔈැ竗ᔈැ屷痗W竗尊痗 LC3B / p62 ; PubMed: 30337536 Cell Death Dis Immunofluorescence staining of U87 and U251 GICs, which treated by DMSO, AZD8055 (0.3 μM) and rapamycin (3 μM). The nuclei were stained with DAPI and the antibody against LC3B and p62. Images were captured by laser confocal microscope ( × 400), scale bar 䲧疝Ỵ疞	24600487 30337536
Growth inhibition assay	Cell viability ; PubMed: 29263324 Nat Commun Growth for the indicated cell lines was assessed after 72 h of treatment with AZD8055 (0–250 nM). Results are expressed as a percentage of cell number relative to the DMSO-treated control cells a.	29263324

体内研究

AZD8055 按2.5/10 mg/kg剂量作用于U87MG和A549移植瘤抑制pS6和pAKT，导致肿瘤生长受抑制。AZD8055按10/20 mg/kg剂量处理多种移植瘤包括U87MG, BT474c, A549, Calu-3, LoVo, SW620, PC3和MES-SA时，显示出明显的抗癌活性。^[1] AZD8055诱导肿瘤体积下降约40%, 伴随着AKT, S6K，和SGK蛋白激酶磷酸化的切除。用AZD8055 (5mg/kg, 每天2次) 和SAHA (100 mg/kg/每天)处理PTEN+/−LKB1+/hypo 移植瘤，导致肿瘤生长全部受抑制，且对鼠mTORC1和mTORC2信号抑制没有副作用。^[4]

激酶实验：^[1]	- 合并抑制mTOR的细胞为基础的测定实验: 通过高通量筛选细胞检测法，使用MDA-MB-468细胞，测定mTORC1 和mTORC2活性。用增加浓度的AZD8055处理细胞2小时。温育到最后时，细胞进行固定，冲洗，用p-Akt（S473）抗体和p-S6（S235/236)抗体探测。用激光扫描仪检测磷酸化水平。
细胞实验：^[1]	- 合并 Cell lines: U87MG, A549，和H838 细胞 Concentrations: 溶解在DMSO中，作为10 mM 储备液, 0.001-1.0 μM Incubation Time: 72到96小时 Method: 用AZD8055处理细胞72到96小时，用0.03 mg/mL Hoechst 33342染色细胞核，用1 μg/mL 吖啶橙染色酸性小囊泡染色。通过ArrayScan II平台在450和536纳米处获得图像，测量酸性小囊泡的百分数和细胞数量。进行LC3测评，用10 μg/mL e64d/抑肽素处理细胞30 到90分钟，然后和AZD8055温育。细胞溶解在冰上，通过免疫印迹法分析。 (Only for Reference)
动物实验：^[1]	- 合并 Animal Models: U87MG, BT474c, A549, Calu-3, LoVo, SW620, PC3 and MES-SA U87-MG和A549细胞建立在无病原体，雌性裸鼠体内(nu/nu:Alpk)。 Dosages: 2.5-20 mg/kg Administration: 口服饲喂，每天1到2次。 (Only for Reference)

参考文献

[4] García-Martínez JM, et al. Br J Cancer, 2011, 104(7), 1116-1

- 合并

溶解度 (25°C)

体外	DMSO	50 mg/mL warmed (107.4 mM)
	Ethanol	3 mg/mL (6.44 mM)
	Water	Insoluble
体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： 4% DMSO+30% PEG 300+ddH2O	5mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download AZD8055 SDF

分子量	465.54
化学式	C₂₅H₃₁N₅O₄
CAS号	1009298-09-2
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	N/A

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

临床试验信息 (data from https://clinicaltrials.gov, updated on 2022-01-17)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT01316809	Completed	Drug: AZD8055	Glioblastoma Multiforme\|Anaplastic Astrocytoma\|Anaplastic Oligodendroglioma\|Malignant Glioma\|Brainstem Glioma	National Cancer Institute (NCI)\|National Institutes of Health Clinical Center (CC)	March 4 2011	Phase 1
NCT00999882	Completed	Drug: AZD8055	Cancer\|Advanced Hepatocellular Carcinoma	AstraZeneca	October 2009	Phase 1
NCT00973076	Completed	Drug: AZD8055	Cancer\|Solid Tumors\|Advanced Solid Malignancies	AstraZeneca	August 2009	Phase 1
NCT00731263	Completed	Drug: AZD8055	Solid Tumors	AstraZeneca	July 2008	Phase 1
NCT01194193	Withdrawn	Drug: AZD8055	Cancer\|Advanced Solid Tumours\|Lymphomas	AstraZeneca		Phase 1

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

mTOR Signaling Pathway Map

mTOR Inhibitors with Unique Features

选择性强的mTOR抑制剂

Rapamycin (Sirolimus) : mTORC1-selective, IC50=~0.1 nM.
活性最高的mTOR抑制剂

Rapamycin (Sirolimus) : mTOR, IC50=~0.1 nM.
FDA批准的mTOR抑制剂

Temsirolimus (CCI-779, NSC 683864) : Approved by FDA for Renal Cell Carcinoma (RCC).
最新的mTOR抑制剂

XL388 ^New : Highly potent, selective, ATP-competitive inhibitor of mTOR with IC50 of 9.9 nM, 1000-fold selectivity over the closely related PI3K kinases.

研究领域

产品类型

定制您的化合物库

AZD8055

客户使用Selleck生产的AZD8055发表文献224篇：

产品安全说明书

mTOR抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download AZD8055 SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

临床试验信息 (data from https://clinicaltrials.gov, updated on 2022-01-17)

技术支持

mTOR Signaling Pathway Map

mTOR Inhibitors with Unique Features

相关mTOR产品