AZD8055
AZD8055是一种新型的，ATP竞争性mTOR抑制剂，在MDA-MB-468 细胞中IC50为0.8 nM，与作用于PI3K亚型和ATM/DNA-PK相比，具有优异的选择性（约1000倍）。AZD8055可诱导半胱天冬酶依赖的凋亡和自噬。Phase 1。
AZD8055 Chemical Structure
CAS: 1009298-09-2
客户使用Selleck的AZD8055发表文献245篇
产品质控
批次：
纯度：
99.84%
99.84
AZD8055相关产品
相关信号通路图
mTOR抑制剂选择性比较
细胞实验数据示例
| 细胞系 | 实验类型 | 给药浓度 | 孵育时间 | 活性描述 | 文献信息 |
|---|---|---|---|---|---|
| H1048 | Apoptosis Assay | 500 nM | 72 h | nhances ABT-263–induced apoptosis | 25737542 |
| H86 | Apoptosis Assay | 500 nM | 72 h | nhances ABT-263–induced apoptosis | 25737542 |
| H196 | Apoptosis Assay | 500 nM | 72 h | nhances ABT-263–induced apoptosis | 25737542 |
| H446 | Apoptosis Assay | 500 nM | 72 h | nhances ABT-263–induced apoptosis | 25737542 |
| OCI/AML3 | Growth Inhibition Assay | 0.2 μM | 48 h | enhances cell growth inhibition induced by selumetinib | 24739393 |
| U937 | Growth Inhibition Assay | 0.2 μM | 48 h | enhances cell growth inhibition induced by selumetinib | 24739393 |
| MOLM13 | Growth Inhibition Assay | 0.2 μM | 48 h | enhances cell growth inhibition induced by selumetinib | 24739393 |
| MCF7 | Growth Inhibition Assay | 20 nM | 72 h | reduces the PELP1-mediated increase in cell viability | 24688046 |
| 293T | Function Assay | 20 nM | 3 h | disrupts Akt-mediated TIF-IA stability, translocation, and activity | 24363449 |
| SW620 | Growth Inhibition Assay | 0.001-10μM | 24 h | inhibits the cell proliferation as the concentration rises | 24363449 |
| Huh7 | Growth Inhibition Assay | 5-100 nM | 0-24 h | increases cell death in a concentration- and time-dependent manner | 24297300 |
| Hep3B | Growth Inhibition Assay | 5-100 nM | 0-24 h | increases cell death in a concentration- and time-dependent manner | 24297300 |
| Huh7 | Function Assay | 100 nM | 12 h | induces autophagy | 24297300 |
| L3.6pl | Growth Inhibition Assay | 1 μM | 72 h | inhibits the cell growth combined with BMS-777607 | 24233399 |
| TE671 | Apoptosis Assay | 1 μM | 48 h | increases cell apoptosis induced by ABT-737 | 24133218 |
| RD | Apoptosis Assay | 1 μM | 48 h | increases cell apoptosis induced by ABT-737 | 24133218 |
| RMS13 | Apoptosis Assay | 1 μM | 48 h | increases cell apoptosis induced by ABT-737 | 24133218 |
| RH30 | Apoptosis Assay | 1 μM | 48 h | increases cell apoptosis induced by ABT-737 | 24133218 |
| Hep-2 | Growth Inhibition Assay | 0.01-1 μM | 12-96 h | increases cell death in a concentration- and time-dependent manner | 24103749 |
| SCC-9 | Growth Inhibition Assay | 0.01-1 μM | 12-96 h | increases cell death in a concentration- and time-dependent manner | 24103749 |
| Hep-2 | Function Assay | 0.1/0.5 μM | 24 h | blocks mTORC1 and mTORC2 activation | 24103749 |
| SCC-9 | Function Assay | 0.1/0.5 μM | 24 h | blocks mTORC1 and mTORC2 activation | 24103749 |
| PANC-1 | Apoptosis Assay | 500 nM | 48 h | sensitizes pancreatic cancer cells to radiotherapy | 23886294 |
| RMG2 | Apoptosis Assay | 1-1000 nM | 72 h | inhibits the cell viability concentration dependently | 23615631 |
| HAC2 | Apoptosis Assay | 1-1000 nM | 72 h | inhibits the cell viability concentration dependently | 23615631 |
| HT-29 | Apoptosis Assay | 1 μM | 72 h | attenuates 5-FU-induced cell death | 21949121 |
| DLD1 | Apoptosis Assay | 1 μM | 72 h | attenuates 5-FU-induced cell death | 21949121 |
| HT-29 | Function Assay | 1 μM | 72 h | induces autophagy to confer cytoprotection | 21949121 |
| DLD1 | Function Assay | 1 μM | 72 h | induces autophagy to confer cytoprotection | 21949121 |
| H838 | Function Assay | 1 μM | 48 h | induces cell autophagy | 20364113 |
| H838 | Growth Inhibition Assay | 0-3 μM | 72 h | induces growth inhibition and autophagy | 20028854 |
| A549 | Growth Inhibition Assay | 0-3 μM | 72 h | induces growth inhibition and autophagy | 20028854 |
| TFK-1 | Growth Inhibition Assay | 72 h | IC50=47 nM | 25152244 | |
| EGI-1 | Growth Inhibition Assay | 72 h | IC50=53 nM | 25152244 | |
| U87-MG | Growth Inhibition Assay | 72 h | GI50 = 79 nM | 24249640 | |
| Mewo | Growth Inhibition Assay | IC50=1.09248 μM | SANGER | ||
| 786-0 | Growth Inhibition Assay | IC50=1.08934 μM | SANGER | ||
| SH-4 | Growth Inhibition Assay | IC50=1.08431 μM | SANGER | ||
| KOSC-2 | Growth Inhibition Assay | IC50=1.08021 μM | SANGER | ||
| OS-RC-2 | Growth Inhibition Assay | IC50=1.0794 μM | SANGER | ||
| D-566MG | Growth Inhibition Assay | IC50=1.06726 μM | SANGER | ||
| SCH | Growth Inhibition Assay | IC50=1.0345 μM | SANGER | ||
| P12-ICHIKAWA | Growth Inhibition Assay | IC50=1.03406 μM | SANGER | ||
| PANC-03-27 | Growth Inhibition Assay | IC50=1.03141 μM | SANGER | ||
| D-423MG | Growth Inhibition Assay | IC50=1.02963 μM | SANGER | ||
| GI-ME-N | Growth Inhibition Assay | IC50=1.02827 μM | SANGER | ||
| LU-134-A | Growth Inhibition Assay | IC50=1.02675 μM | SANGER | ||
| T98G | Growth Inhibition Assay | IC50=1.01364 μM | SANGER | ||
| SW13 | Growth Inhibition Assay | IC50=0.98392 μM | SANGER | ||
| A2058 | Growth Inhibition Assay | IC50=0.9736 μM | SANGER | ||
| NCI-H1792 | Growth Inhibition Assay | IC50=0.97101 μM | SANGER | ||
| DEL | Growth Inhibition Assay | IC50=0.96773 μM | SANGER | ||
| A427 | Growth Inhibition Assay | IC50=0.96198 μM | SANGER | ||
| SNU-449 | Growth Inhibition Assay | IC50=0.95924 μM | SANGER | ||
| ACN | Growth Inhibition Assay | IC50=0.94277 μM | SANGER | ||
| MOLT-16 | Growth Inhibition Assay | IC50=0.93845 μM | SANGER | ||
| DMS-114 | Growth Inhibition Assay | IC50=0.93677 μM | SANGER | ||
| HCC1806 | Growth Inhibition Assay | IC50=0.93256 μM | SANGER | ||
| MIA-PaCa-2 | Growth Inhibition Assay | IC50=0.92922 μM | SANGER | ||
| RXF393 | Growth Inhibition Assay | IC50=0.92897 μM | SANGER | ||
| UACC-893 | Growth Inhibition Assay | IC50=0.92855 μM | SANGER | ||
| C-33-A | Growth Inhibition Assay | IC50=0.90442 μM | SANGER | ||
| NCI-H1573 | Growth Inhibition Assay | IC50=0.90229 μM | SANGER | ||
| ETK-1 | Growth Inhibition Assay | IC50=0.89372 μM | SANGER | ||
| BxPC-3 | Growth Inhibition Assay | IC50=0.88833 μM | SANGER | ||
| BHY | Growth Inhibition Assay | IC50=0.88734 μM | SANGER | ||
| SF126 | Growth Inhibition Assay | IC50=0.88714 μM | SANGER | ||
| BPH-1 | Growth Inhibition Assay | IC50=0.88395 μM | SANGER | ||
| CP50-MEL-B | Growth Inhibition Assay | IC50=0.88384 μM | SANGER | ||
| HCC1419 | Growth Inhibition Assay | IC50=0.86928 μM | SANGER | ||
| RKO | Growth Inhibition Assay | IC50=0.86817 μM | SANGER | ||
| CAL-33 | Growth Inhibition Assay | IC50=0.86495 μM | SANGER | ||
| CAL-120 | Growth Inhibition Assay | IC50=0.86041 μM | SANGER | ||
| RPMI-8866 | Growth Inhibition Assay | IC50=0.85822 μM | SANGER | ||
| HCC1569 | Growth Inhibition Assay | IC50=0.85207 μM | SANGER | ||
| KU-19-19 | Growth Inhibition Assay | IC50=0.85121 μM | SANGER | ||
| RT-112 | Growth Inhibition Assay | IC50=0.84937 μM | SANGER | ||
| HD-MY-Z | Growth Inhibition Assay | IC50=0.84092 μM | SANGER | ||
| MHH-ES-1 | Growth Inhibition Assay | IC50=0.83457 μM | SANGER | ||
| A431 | Growth Inhibition Assay | IC50=0.83116 μM | SANGER | ||
| PFSK-1 | Growth Inhibition Assay | IC50=0.83039 μM | SANGER | ||
| KYSE-450 | Growth Inhibition Assay | IC50=0.82725 μM | SANGER | ||
| OCUB-M | Growth Inhibition Assay | IC50=0.82675 μM | SANGER | ||
| NCI-H2347 | Growth Inhibition Assay | IC50=0.82401 μM | SANGER | ||
| OVCAR-4 | Growth Inhibition Assay | IC50=0.81911 μM | SANGER | ||
| A704 | Growth Inhibition Assay | IC50=0.81798 μM | SANGER | ||
| SNU-423 | Growth Inhibition Assay | IC50=0.81422 μM | SANGER | ||
| HPAF-II | Growth Inhibition Assay | IC50=0.80794 μM | SANGER | ||
| SN12C | Growth Inhibition Assay | IC50=0.80668 μM | SANGER | ||
| NCI-H1770 | Growth Inhibition Assay | IC50=0.8021 μM | SANGER | ||
| CAL-62 | Growth Inhibition Assay | IC50=0.79924 μM | SANGER | ||
| OE33 | Growth Inhibition Assay | IC50=0.79914 μM | SANGER | ||
| DOHH-2 | Growth Inhibition Assay | IC50=0.7933 μM | SANGER | ||
| NCI-H650 | Growth Inhibition Assay | IC50=0.79144 μM | SANGER | ||
| NCI-H1563 | Growth Inhibition Assay | IC50=0.78926 μM | SANGER | ||
| Ca9-22 | Growth Inhibition Assay | IC50=0.78736 μM | SANGER | ||
| VMRC-RCZ | Growth Inhibition Assay | IC50=0.78482 μM | SANGER | ||
| KYSE-140 | Growth Inhibition Assay | IC50=0.78168 μM | SANGER | ||
| CAL-12T | Growth Inhibition Assay | IC50=0.78029 μM | SANGER | ||
| LU-99A | Growth Inhibition Assay | IC50=0.77649 μM | SANGER | ||
| PSN1 | Growth Inhibition Assay | IC50=0.77057 μM | SANGER | ||
| DMS-273 | Growth Inhibition Assay | IC50=0.76922 μM | SANGER | ||
| NCI-H1623 | Growth Inhibition Assay | IC50=0.76261 μM | SANGER | ||
| NCI-H747 | Growth Inhibition Assay | IC50=0.75991 μM | SANGER | ||
| U-2-OS | Growth Inhibition Assay | IC50=0.7597 μM | SANGER | ||
| RS4-11 | Growth Inhibition Assay | IC50=0.75943 μM | SANGER | ||
| A375 | Growth Inhibition Assay | IC50=0.75193 μM | SANGER | ||
| HLE | Growth Inhibition Assay | IC50=0.74844 μM | SANGER | ||
| MHH-PREB-1 | Growth Inhibition Assay | IC50=0.74736 μM | SANGER | ||
| CAKI-1 | Growth Inhibition Assay | IC50=0.74629 μM | SANGER | ||
| AsPC-1 | Growth Inhibition Assay | IC50=0.73795 μM | SANGER | ||
| RPMI-7951 | Growth Inhibition Assay | IC50=0.73533 μM | SANGER | ||
| HTC-C3 | Growth Inhibition Assay | IC50=0.73172 μM | SANGER | ||
| OMC-1 | Growth Inhibition Assay | IC50=0.72738 μM | SANGER | ||
| MC-IXC | Growth Inhibition Assay | IC50=0.72718 μM | SANGER | ||
| C32 | Growth Inhibition Assay | IC50=0.72484 μM | SANGER | ||
| PC-3 | Growth Inhibition Assay | IC50=0.7223 μM | SANGER | ||
| EFM-19 | Growth Inhibition Assay | IC50=0.70847 μM | SANGER | ||
| 8305C | Growth Inhibition Assay | IC50=0.70755 μM | SANGER | ||
| 22RV1 | Growth Inhibition Assay | IC50=0.70717 μM | SANGER | ||
| NUGC-3 | Growth Inhibition Assay | IC50=0.70691 μM | SANGER | ||
| ATN-1 | Growth Inhibition Assay | IC50=0.7059 μM | SANGER | ||
| NB5 | Growth Inhibition Assay | IC50=0.70319 μM | SANGER | ||
| NCI-H1648 | Growth Inhibition Assay | IC50=0.70173 μM | SANGER | ||
| NTERA-S-cl-D1 | Growth Inhibition Assay | IC50=0.70063 μM | SANGER | ||
| COLO-800 | Growth Inhibition Assay | IC50=0.69813 μM | SANGER | ||
| WM-115 | Growth Inhibition Assay | IC50=0.68924 μM | SANGER | ||
| SF295 | Growth Inhibition Assay | IC50=0.68507 μM | SANGER | ||
| SW982 | Growth Inhibition Assay | IC50=0.68501 μM | SANGER | ||
| EW-22 | Growth Inhibition Assay | IC50=0.68444 μM | SANGER | ||
| TE-5 | Growth Inhibition Assay | IC50=0.68405 μM | SANGER | ||
| HO-1-N-1 | Growth Inhibition Assay | IC50=0.68064 μM | SANGER | ||
| EFO-27 | Growth Inhibition Assay | IC50=0.67979 μM | SANGER | ||
| MN-60 | Growth Inhibition Assay | IC50=0.67846 μM | SANGER | ||
| MDA-MB-157 | Growth Inhibition Assay | IC50=0.6781 μM | SANGER | ||
| MEL-HO | Growth Inhibition Assay | IC50=0.67752 μM | SANGER | ||
| MOLT-4 | Growth Inhibition Assay | IC50=0.67689 μM | SANGER | ||
| IGROV-1 | Growth Inhibition Assay | IC50=0.6745 μM | SANGER | ||
| SK-OV-3 | Growth Inhibition Assay | IC50=0.67187 μM | SANGER | ||
| MOLT-13 | Growth Inhibition Assay | IC50=0.66537 μM | SANGER | ||
| KYSE-150 | Growth Inhibition Assay | IC50=0.66186 μM | SANGER | ||
| SK-MEL-2 | Growth Inhibition Assay | IC50=0.64153 μM | SANGER | ||
| RVH-421 | Growth Inhibition Assay | IC50=0.63639 μM | SANGER | ||
| SW1710 | Growth Inhibition Assay | IC50=0.63167 μM | SANGER | ||
| NCI-H522 | Growth Inhibition Assay | IC50=0.62992 μM | SANGER | ||
| SK-NEP-1 | Growth Inhibition Assay | IC50=0.62502 μM | SANGER | ||
| CAMA-1 | Growth Inhibition Assay | IC50=0.62152 μM | SANGER | ||
| BFTC-905 | Growth Inhibition Assay | IC50=0.62126 μM | SANGER | ||
| NCI-H2452 | Growth Inhibition Assay | IC50=0.61917 μM | SANGER | ||
| KGN | Growth Inhibition Assay | IC50=0.61049 μM | SANGER | ||
| NCI-H1437 | Growth Inhibition Assay | IC50=0.60619 μM | SANGER | ||
| HL-60 | Growth Inhibition Assay | IC50=0.60351 μM | SANGER | ||
| H4 | Growth Inhibition Assay | IC50=0.60094 μM | SANGER | ||
| Hs-578-T | Growth Inhibition Assay | IC50=0.59851 μM | SANGER | ||
| IA-LM | Growth Inhibition Assay | IC50=0.59609 μM | SANGER | ||
| OAW-42 | Growth Inhibition Assay | IC50=0.59162 μM | SANGER | ||
| PC-14 | Growth Inhibition Assay | IC50=0.5897 μM | SANGER | ||
| BCPAP | Growth Inhibition Assay | IC50=0.58791 μM | SANGER | ||
| NCI-H28 | Growth Inhibition Assay | IC50=0.58675 μM | SANGER | ||
| NCI-H1048 | Growth Inhibition Assay | IC50=0.58645 μM | SANGER | ||
| SCC-4 | Growth Inhibition Assay | IC50=0.58541 μM | SANGER | ||
| ML-2 | Growth Inhibition Assay | IC50=0.58478 μM | SANGER | ||
| MSTO-211H | Growth Inhibition Assay | IC50=0.57751 μM | SANGER | ||
| MDA-MB-175-VII | Growth Inhibition Assay | IC50=0.57741 μM | SANGER | ||
| SW780 | Growth Inhibition Assay | IC50=0.57595 μM | SANGER | ||
| PANC-08-13 | Growth Inhibition Assay | IC50=0.57389 μM | SANGER | ||
| HOS | Growth Inhibition Assay | IC50=0.57192 μM | SANGER | ||
| KG-1 | Growth Inhibition Assay | IC50=0.56884 μM | SANGER | ||
| SK-MEL-28 | Growth Inhibition Assay | IC50=0.5591 μM | SANGER | ||
| GAMG | Growth Inhibition Assay | IC50=0.55658 μM | SANGER | ||
| ES1 | Growth Inhibition Assay | IC50=0.55518 μM | SANGER | ||
| LOXIMVI | Growth Inhibition Assay | IC50=0.55123 μM | SANGER | ||
| YH-13 | Growth Inhibition Assay | IC50=0.54938 μM | SANGER | ||
| NCI-H1355 | Growth Inhibition Assay | IC50=0.53878 μM | SANGER | ||
| NCI-H1793 | Growth Inhibition Assay | IC50=0.53447 μM | SANGER | ||
| J-RT3-T3-5 | Growth Inhibition Assay | IC50=0.53195 μM | SANGER | ||
| GR-ST | Growth Inhibition Assay | IC50=0.53015 μM | SANGER | ||
| HT-1080 | Growth Inhibition Assay | IC50=0.52543 μM | SANGER | ||
| CAL-39 | Growth Inhibition Assay | IC50=0.52268 μM | SANGER | ||
| DOK | Growth Inhibition Assay | IC50=0.51333 μM | SANGER | ||
| MDA-MB-361 | Growth Inhibition Assay | IC50=0.5087 μM | SANGER | ||
| NCI-H460 | Growth Inhibition Assay | IC50=0.50597 μM | SANGER | ||
| KNS-62 | Growth Inhibition Assay | IC50=0.50568 μM | SANGER | ||
| DB | Growth Inhibition Assay | IC50=0.50021 μM | SANGER | ||
| A101D | Growth Inhibition Assay | IC50=0.48968 μM | SANGER | ||
| VM-CUB-1 | Growth Inhibition Assay | IC50=0.47286 μM | SANGER | ||
| SW962 | Growth Inhibition Assay | IC50=0.4719 μM | SANGER | ||
| M14 | Growth Inhibition Assay | IC50=0.4717 μM | SANGER | ||
| MPP-89 | Growth Inhibition Assay | IC50=0.46947 μM | SANGER | ||
| JVM-3 | Growth Inhibition Assay | IC50=0.46292 μM | SANGER | ||
| GCIY | Growth Inhibition Assay | IC50=0.45754 μM | SANGER | ||
| COLO-684 | Growth Inhibition Assay | IC50=0.45726 μM | SANGER | ||
| TI-73 | Growth Inhibition Assay | IC50=0.45686 μM | SANGER | ||
| ES4 | Growth Inhibition Assay | IC50=0.45336 μM | SANGER | ||
| QIMR-WIL | Growth Inhibition Assay | IC50=0.4515 μM | SANGER | ||
| SJSA-1 | Growth Inhibition Assay | IC50=0.44554 μM | SANGER | ||
| SK-MES-1 | Growth Inhibition Assay | IC50=0.43848 μM | SANGER | ||
| CHP-212 | Growth Inhibition Assay | IC50=0.43697 μM | SANGER | ||
| HuH-7 | Growth Inhibition Assay | IC50=0.43372 μM | SANGER | ||
| KE-37 | Growth Inhibition Assay | IC50=0.43247 μM | SANGER | ||
| EPLC-272H | Growth Inhibition Assay | IC50=0.43077 μM | SANGER | ||
| KP-N-YS | Growth Inhibition Assay | IC50=0.4307 μM | SANGER | ||
| MFE-280 | Growth Inhibition Assay | IC50=0.43032 μM | SANGER | ||
| OVCAR-5 | Growth Inhibition Assay | IC50=0.42933 μM | SANGER | ||
| HSC-3 | Growth Inhibition Assay | IC50=0.42908 μM | SANGER | ||
| MFM-223 | Growth Inhibition Assay | IC50=0.42617 μM | SANGER | ||
| COR-L88 | Growth Inhibition Assay | IC50=0.42267 μM | SANGER | ||
| NEC8 | Growth Inhibition Assay | IC50=0.41695 μM | SANGER | ||
| NOS-1 | Growth Inhibition Assay | IC50=0.41074 μM | SANGER | ||
| MZ2-MEL | Growth Inhibition Assay | IC50=0.40882 μM | SANGER | ||
| BHT-101 | Growth Inhibition Assay | IC50=0.40787 μM | SANGER | ||
| HuO9 | Growth Inhibition Assay | IC50=0.40667 μM | SANGER | ||
| MCF7 | Growth Inhibition Assay | IC50=0.4053 μM | SANGER | ||
| SK-LU-1 | Growth Inhibition Assay | IC50=0.39208 μM | SANGER | ||
| L-363 | Growth Inhibition Assay | IC50=0.39026 μM | SANGER | ||
| HuO-3N1 | Growth Inhibition Assay | IC50=0.38379 μM | SANGER | ||
| ES8 | Growth Inhibition Assay | IC50=0.36553 μM | SANGER | ||
| LNCaP-Clone-FGC | Growth Inhibition Assay | IC50=0.35314 μM | SANGER | ||
| ECC10 | Growth Inhibition Assay | IC50=0.35035 μM | SANGER | ||
| NCI-H520 | Growth Inhibition Assay | IC50=0.34834 μM | SANGER | ||
| VA-ES-BJ | Growth Inhibition Assay | IC50=0.34268 μM | SANGER | ||
| EM-2 | Growth Inhibition Assay | IC50=0.34188 μM | SANGER | ||
| LB1047-RCC | Growth Inhibition Assay | IC50=0.34047 μM | SANGER | ||
| PA-1 | Growth Inhibition Assay | IC50=0.33619 μM | SANGER | ||
| P30-OHK | Growth Inhibition Assay | IC50=0.32705 μM | SANGER | ||
| CHL-1 | Growth Inhibition Assay | IC50=0.32703 μM | SANGER | ||
| NCI-SNU-1 | Growth Inhibition Assay | IC50=0.32331 μM | SANGER | ||
| TYK-nu | Growth Inhibition Assay | IC50=0.31864 μM | SANGER | ||
| G-401 | Growth Inhibition Assay | IC50=0.30986 μM | SANGER | ||
| BB65-RCC | Growth Inhibition Assay | IC50=0.30805 μM | SANGER | ||
| LB2241-RCC | Growth Inhibition Assay | IC50=0.30198 μM | SANGER | ||
| A3-KAW | Growth Inhibition Assay | IC50=0.2974 μM | SANGER | ||
| HT | Growth Inhibition Assay | IC50=0.2938 μM | SANGER | ||
| NCI-H292 | Growth Inhibition Assay | IC50=0.29164 μM | SANGER | ||
| RPMI-8226 | Growth Inhibition Assay | IC50=0.28589 μM | SANGER | ||
| T47D | Growth Inhibition Assay | IC50=0.27475 μM | SANGER | ||
| MG-63 | Growth Inhibition Assay | IC50=0.27407 μM | SANGER | ||
| ES7 | Growth Inhibition Assay | IC50=0.27383 μM | SANGER | ||
| 697 | Growth Inhibition Assay | IC50=0.27367 μM | SANGER | ||
| CTB-1 | Growth Inhibition Assay | IC50=0.27215 μM | SANGER | ||
| LK-2 | Growth Inhibition Assay | IC50=0.26824 μM | SANGER | ||
| HGC-27 | Growth Inhibition Assay | IC50=0.26414 μM | SANGER | ||
| LXF-289 | Growth Inhibition Assay | IC50=0.25041 μM | SANGER | ||
| LC-2-ad | Growth Inhibition Assay | IC50=0.22084 μM | SANGER | ||
| BEN | Growth Inhibition Assay | IC50=0.21293 μM | SANGER | ||
| HCC2218 | Growth Inhibition Assay | IC50=0.20688 μM | SANGER | ||
| HAL-01 | Growth Inhibition Assay | IC50=0.20297 μM | SANGER | ||
| LoVo | Growth Inhibition Assay | IC50=0.20202 μM | SANGER | ||
| NKM-1 | Growth Inhibition Assay | IC50=0.20029 μM | SANGER | ||
| CAL-51 | Growth Inhibition Assay | IC50=0.19651 μM | SANGER | ||
| A549 | Growth Inhibition Assay | IC50=0.1955 μM | SANGER | ||
| A204 | Growth Inhibition Assay | IC50=0.1897 μM | SANGER | ||
| NCI-H1581 | Growth Inhibition Assay | IC50=0.18966 μM | SANGER | ||
| LAMA-84 | Growth Inhibition Assay | IC50=0.18032 μM | SANGER | ||
| NBsusSR | Growth Inhibition Assay | IC50=0.17019 μM | SANGER | ||
| Ramos-2G6-4C10 | Growth Inhibition Assay | IC50=0.16983 μM | SANGER | ||
| NB14 | Growth Inhibition Assay | IC50=0.16447 μM | SANGER | ||
| D-283MED | Growth Inhibition Assay | IC50=0.14723 μM | SANGER | ||
| ME-180 | Growth Inhibition Assay | IC50=0.14681 μM | SANGER | ||
| EW-18 | Growth Inhibition Assay | IC50=0.14073 μM | SANGER | ||
| EGI-1 | Growth Inhibition Assay | IC50=0.13531 μM | SANGER | ||
| NB69 | Growth Inhibition Assay | IC50=0.135 μM | SANGER | ||
| MV-4-11 | Growth Inhibition Assay | IC50=0.10347 μM | SANGER | ||
| G-402 | Growth Inhibition Assay | IC50=0.0998 μM | SANGER | ||
| ES5 | Growth Inhibition Assay | IC50=0.0935 μM | SANGER | ||
| BV-173 | Growth Inhibition Assay | IC50=0.09061 μM | SANGER | ||
| CTV-1 | Growth Inhibition Assay | IC50=0.08641 μM | SANGER | ||
| DU-4475 | Growth Inhibition Assay | IC50=0.08047 μM | SANGER | ||
| KU812 | Growth Inhibition Assay | IC50=0.08043 μM | SANGER | ||
| HH | Growth Inhibition Assay | IC50=0.08009 μM | SANGER | ||
| AN3-CA | Growth Inhibition Assay | IC50=0.07951 μM | SANGER | ||
| H9 | Growth Inhibition Assay | IC50=0.06692 μM | SANGER | ||
| EoL-1-cell | Growth Inhibition Assay | IC50=0.06569 μM | SANGER | ||
| NCI-H209 | Growth Inhibition Assay | IC50=0.05453 μM | SANGER | ||
| SBC-1 | Growth Inhibition Assay | IC50=0.04581 μM | SANGER | ||
| EW-3 | Growth Inhibition Assay | IC50=0.04056 μM | SANGER | ||
| KARPAS-45 | Growth Inhibition Assay | IC50=0.03371 μM | SANGER | ||
| NCI-H720 | Growth Inhibition Assay | IC50=0.02938 μM | SANGER | ||
| LU-139 | Growth Inhibition Assay | IC50=0.02331 μM | SANGER | ||
| AGS | Growth Inhibition Assay | IC50=1.09459 μM | SANGER | ||
| Daoy | Growth Inhibition Assay | IC50=1.09628 μM | SANGER | ||
| SW48 | Growth Inhibition Assay | IC50=1.10911 μM | SANGER | ||
| KYSE-180 | Growth Inhibition Assay | IC50=1.11021 μM | SANGER | ||
| NH-12 | Growth Inhibition Assay | IC50=1.11237 μM | SANGER | ||
| BE-13 | Growth Inhibition Assay | IC50=1.11759 μM | SANGER | ||
| ES3 | Growth Inhibition Assay | IC50=1.13171 μM | SANGER | ||
| NCI-H1092 | Growth Inhibition Assay | IC50=1.134 μM | SANGER | ||
| NCI-H1755 | Growth Inhibition Assay | IC50=1.13941 μM | SANGER | ||
| EKVX | Growth Inhibition Assay | IC50=1.14001 μM | SANGER | ||
| NB13 | Growth Inhibition Assay | IC50=1.1445 μM | SANGER | ||
| NCI-H2405 | Growth Inhibition Assay | IC50=1.14574 μM | SANGER | ||
| LS-411N | Growth Inhibition Assay | IC50=1.15017 μM | SANGER | ||
| MDA-MB-453 | Growth Inhibition Assay | IC50=1.15624 μM | SANGER | ||
| SCC-15 | Growth Inhibition Assay | IC50=1.16956 μM | SANGER | ||
| C2BBe1 | Growth Inhibition Assay | IC50=1.17056 μM | SANGER | ||
| HT-144 | Growth Inhibition Assay | IC50=1.1707 μM | SANGER | ||
| HEC-1 | Growth Inhibition Assay | IC50=1.17627 μM | SANGER | ||
| HCE-T | Growth Inhibition Assay | IC50=1.17983 μM | SANGER | ||
| IST-MEL1 | Growth Inhibition Assay | IC50=1.19082 μM | SANGER | ||
| Detroit562 | Growth Inhibition Assay | IC50=1.19439 μM | SANGER | ||
| A4-Fuk | Growth Inhibition Assay | IC50=1.20441 μM | SANGER | ||
| HDLM-2 | Growth Inhibition Assay | IC50=1.21326 μM | SANGER | ||
| MKN7 | Growth Inhibition Assay | IC50=1.21702 μM | SANGER | ||
| MDA-MB-415 | Growth Inhibition Assay | IC50=1.21702 μM | SANGER | ||
| BT-20 | Growth Inhibition Assay | IC50=1.22444 μM | SANGER | ||
| NCI-H2030 | Growth Inhibition Assay | IC50=1.24106 μM | SANGER | ||
| LS-123 | Growth Inhibition Assay | IC50=1.24753 μM | SANGER | ||
| SK-MEL-3 | Growth Inhibition Assay | IC50=1.24776 μM | SANGER | ||
| KS-1 | Growth Inhibition Assay | IC50=1.25171 μM | SANGER | ||
| LU-65 | Growth Inhibition Assay | IC50=1.25606 μM | SANGER | ||
| NCI-H596 | Growth Inhibition Assay | IC50=1.25929 μM | SANGER | ||
| KYSE-410 | Growth Inhibition Assay | IC50=1.27014 μM | SANGER | ||
| NCI-H2228 | Growth Inhibition Assay | IC50=1.27167 μM | SANGER | ||
| LN-405 | Growth Inhibition Assay | IC50=1.28021 μM | SANGER | ||
| 8505C | Growth Inhibition Assay | IC50=1.28823 μM | SANGER | ||
| BFTC-909 | Growth Inhibition Assay | IC50=1.29434 μM | SANGER | ||
| OC-314 | Growth Inhibition Assay | IC50=1.29929 μM | SANGER | ||
| NMC-G1 | Growth Inhibition Assay | IC50=1.31135 μM | SANGER | ||
| SKG-IIIa | Growth Inhibition Assay | IC50=1.31428 μM | SANGER | ||
| GAK | Growth Inhibition Assay | IC50=1.31858 μM | SANGER | ||
| D-263MG | Growth Inhibition Assay | IC50=1.32641 μM | SANGER | ||
| NCI-H446 | Growth Inhibition Assay | IC50=1.32902 μM | SANGER | ||
| TGBC1TKB | Growth Inhibition Assay | IC50=1.32998 μM | SANGER | ||
| GCT | Growth Inhibition Assay | IC50=1.34345 μM | SANGER | ||
| COR-L23 | Growth Inhibition Assay | IC50=1.34845 μM | SANGER | ||
| TK10 | Growth Inhibition Assay | IC50=1.35797 μM | SANGER | ||
| ES6 | Growth Inhibition Assay | IC50=1.36376 μM | SANGER | ||
| SW1088 | Growth Inhibition Assay | IC50=1.36612 μM | SANGER | ||
| AM-38 | Growth Inhibition Assay | IC50=1.37199 μM | SANGER | ||
| CHP-134 | Growth Inhibition Assay | IC50=1.37844 μM | SANGER | ||
| SW872 | Growth Inhibition Assay | IC50=1.38555 μM | SANGER | ||
| LB831-BLC | Growth Inhibition Assay | IC50=1.39067 μM | SANGER | ||
| TE-12 | Growth Inhibition Assay | IC50=1.40601 μM | SANGER | ||
| LCLC-97TM1 | Growth Inhibition Assay | IC50=1.41046 μM | SANGER | ||
| HCT-116 | Growth Inhibition Assay | IC50=1.42854 μM | SANGER | ||
| ALL-PO | Growth Inhibition Assay | IC50=1.43774 μM | SANGER | ||
| EW-16 | Growth Inhibition Assay | IC50=1.43842 μM | SANGER | ||
| NCI-H661 | Growth Inhibition Assay | IC50=1.44775 μM | SANGER | ||
| TE-8 | Growth Inhibition Assay | IC50=1.4556 μM | SANGER | ||
| TCCSUP | Growth Inhibition Assay | IC50=1.4696 μM | SANGER | ||
| SW1990 | Growth Inhibition Assay | IC50=1.47533 μM | SANGER | ||
| UM-UC-3 | Growth Inhibition Assay | IC50=1.47675 μM | SANGER | ||
| HuP-T4 | Growth Inhibition Assay | IC50=1.48607 μM | SANGER | ||
| NCI-H1299 | Growth Inhibition Assay | IC50=1.50086 μM | SANGER | ||
| RO82-W-1 | Growth Inhibition Assay | IC50=1.52081 μM | SANGER | ||
| Becker | Growth Inhibition Assay | IC50=1.52187 μM | SANGER | ||
| SNU-387 | Growth Inhibition Assay | IC50=1.52241 μM | SANGER | ||
| CAL-85-1 | Growth Inhibition Assay | IC50=1.52599 μM | SANGER | ||
| 647-V | Growth Inhibition Assay | IC50=1.5388 μM | SANGER | ||
| SBC-5 | Growth Inhibition Assay | IC50=1.54593 μM | SANGER | ||
| NCI-H23 | Growth Inhibition Assay | IC50=1.55714 μM | SANGER | ||
| CGTH-W-1 | Growth Inhibition Assay | IC50=1.55819 μM | SANGER | ||
| SK-N-FI | Growth Inhibition Assay | IC50=1.55908 μM | SANGER | ||
| KM-H2 | Growth Inhibition Assay | IC50=1.56474 μM | SANGER | ||
| KY821 | Growth Inhibition Assay | IC50=1.56617 μM | SANGER | ||
| RH-1 | Growth Inhibition Assay | IC50=1.56762 μM | SANGER | ||
| KYSE-270 | Growth Inhibition Assay | IC50=1.57423 μM | SANGER | ||
| SF539 | Growth Inhibition Assay | IC50=1.57969 μM | SANGER | ||
| JEG-3 | Growth Inhibition Assay | IC50=1.58094 μM | SANGER | ||
| SCC-25 | Growth Inhibition Assay | IC50=1.58432 μM | SANGER | ||
| SW1573 | Growth Inhibition Assay | IC50=1.60158 μM | SANGER | ||
| EW-1 | Growth Inhibition Assay | IC50=1.61351 μM | SANGER | ||
| YKG-1 | Growth Inhibition Assay | IC50=1.61438 μM | SANGER | ||
| EW-11 | Growth Inhibition Assay | IC50=1.61741 μM | SANGER | ||
| DJM-1 | Growth Inhibition Assay | IC50=1.61825 μM | SANGER | ||
| Calu-3 | Growth Inhibition Assay | IC50=1.65213 μM | SANGER | ||
| HT-3 | Growth Inhibition Assay | IC50=1.6566 μM | SANGER | ||
| NCI-H69 | Growth Inhibition Assay | IC50=1.67343 μM | SANGER | ||
| NCI-H2126 | Growth Inhibition Assay | IC50=1.67797 μM | SANGER | ||
| RPMI-2650 | Growth Inhibition Assay | IC50=1.68317 μM | SANGER | ||
| TE-6 | Growth Inhibition Assay | IC50=1.70874 μM | SANGER | ||
| MDA-MB-231 | Growth Inhibition Assay | IC50=1.71993 μM | SANGER | ||
| A2780 | Growth Inhibition Assay | IC50=1.72207 μM | SANGER | ||
| GOTO | Growth Inhibition Assay | IC50=1.7356 μM | SANGER | ||
| KYSE-70 | Growth Inhibition Assay | IC50=1.74442 μM | SANGER | ||
| GMS-10 | Growth Inhibition Assay | IC50=1.74662 μM | SANGER | ||
| CaR-1 | Growth Inhibition Assay | IC50=1.74812 μM | SANGER | ||
| SW900 | Growth Inhibition Assay | IC50=1.74993 μM | SANGER | ||
| BB49-HNC | Growth Inhibition Assay | IC50=1.75168 μM | SANGER | ||
| SNB75 | Growth Inhibition Assay | IC50=1.75492 μM | SANGER | ||
| SK-PN-DW | Growth Inhibition Assay | IC50=1.75682 μM | SANGER | ||
| 5637 | Growth Inhibition Assay | IC50=1.77268 μM | SANGER | ||
| BT-474 | Growth Inhibition Assay | IC50=1.78171 μM | SANGER | ||
| KM12 | Growth Inhibition Assay | IC50=1.79741 μM | SANGER | ||
| COLO-680N | Growth Inhibition Assay | IC50=1.82381 μM | SANGER | ||
| Saos-2 | Growth Inhibition Assay | IC50=1.82445 μM | SANGER | ||
| CAL-54 | Growth Inhibition Assay | IC50=1.83313 μM | SANGER | ||
| U-118-MG | Growth Inhibition Assay | IC50=1.84622 μM | SANGER | ||
| TGBC24TKB | Growth Inhibition Assay | IC50=1.85501 μM | SANGER | ||
| NCI-H2052 | Growth Inhibition Assay | IC50=1.8641 μM | SANGER | ||
| BB30-HNC | Growth Inhibition Assay | IC50=1.86462 μM | SANGER | ||
| KNS-81-FD | Growth Inhibition Assay | IC50=1.89165 μM | SANGER | ||
| HN | Growth Inhibition Assay | IC50=1.89545 μM | SANGER | ||
| ACHN | Growth Inhibition Assay | IC50=1.90786 μM | SANGER | ||
| HSC-2 | Growth Inhibition Assay | IC50=1.91096 μM | SANGER | ||
| HCC2998 | Growth Inhibition Assay | IC50=1.93325 μM | SANGER | ||
| HEL | Growth Inhibition Assay | IC50=1.94184 μM | SANGER | ||
| SW684 | Growth Inhibition Assay | IC50=1.97371 μM | SANGER | ||
| NCI-H1693 | Growth Inhibition Assay | IC50=1.98086 μM | SANGER | ||
| 8-MG-BA | Growth Inhibition Assay | IC50=1.9821 μM | SANGER | ||
| OVCAR-8 | Growth Inhibition Assay | IC50=2.00295 μM | SANGER | ||
| DSH1 | Growth Inhibition Assay | IC50=2.01774 μM | SANGER | ||
| KYSE-520 | Growth Inhibition Assay | IC50=2.02049 μM | SANGER | ||
| GB-1 | Growth Inhibition Assay | IC50=2.02577 μM | SANGER | ||
| RCC10RGB | Growth Inhibition Assay | IC50=2.04871 μM | SANGER | ||
| SW954 | Growth Inhibition Assay | IC50=2.05036 μM | SANGER | ||
| IST-MES1 | Growth Inhibition Assay | IC50=2.05568 μM | SANGER | ||
| AU565 | Growth Inhibition Assay | IC50=2.05905 μM | SANGER | ||
| CW-2 | Growth Inhibition Assay | IC50=2.06875 μM | SANGER | ||
| TE-1 | Growth Inhibition Assay | IC50=2.09377 μM | SANGER | ||
| KP-4 | Growth Inhibition Assay | IC50=2.10312 μM | SANGER | ||
| SNU-C2B | Growth Inhibition Assay | IC50=2.10823 μM | SANGER | ||
| NCI-H1395 | Growth Inhibition Assay | IC50=2.10986 μM | SANGER | ||
| CAS-1 | Growth Inhibition Assay | IC50=2.11546 μM | SANGER | ||
| NCI-H1155 | Growth Inhibition Assay | IC50=2.2269 μM | SANGER | ||
| SK-MEL-1 | Growth Inhibition Assay | IC50=2.28181 μM | SANGER | ||
| KINGS-1 | Growth Inhibition Assay | IC50=2.30088 μM | SANGER | ||
| ESS-1 | Growth Inhibition Assay | IC50=2.3051 μM | SANGER | ||
| PANC-10-05 | Growth Inhibition Assay | IC50=2.37024 μM | SANGER | ||
| HT-1376 | Growth Inhibition Assay | IC50=2.38708 μM | SANGER | ||
| LS-513 | Growth Inhibition Assay | IC50=2.38874 μM | SANGER | ||
| KNS-42 | Growth Inhibition Assay | IC50=2.39105 μM | SANGER | ||
| 639-V | Growth Inhibition Assay | IC50=2.42758 μM | SANGER | ||
| SJRH30 | Growth Inhibition Assay | IC50=2.45161 μM | SANGER | ||
| SW1783 | Growth Inhibition Assay | IC50=2.47078 μM | SANGER | ||
| NB6 | Growth Inhibition Assay | IC50=2.4828 μM | SANGER | ||
| SK-MEL-30 | Growth Inhibition Assay | IC50=2.4883 μM | SANGER | ||
| HCE-4 | Growth Inhibition Assay | IC50=2.49402 μM | SANGER | ||
| NB10 | Growth Inhibition Assay | IC50=2.49429 μM | SANGER | ||
| H-EMC-SS | Growth Inhibition Assay | IC50=2.5465 μM | SANGER | ||
| SK-HEP-1 | Growth Inhibition Assay | IC50=2.55236 μM | SANGER | ||
| HCC1395 | Growth Inhibition Assay | IC50=2.55655 μM | SANGER | ||
| HuCCT1 | Growth Inhibition Assay | IC50=2.5639 μM | SANGER | ||
| SiHa | Growth Inhibition Assay | IC50=2.58719 μM | SANGER | ||
| EFO-21 | Growth Inhibition Assay | IC50=2.58764 μM | SANGER | ||
| NCI-H1666 | Growth Inhibition Assay | IC50=2.59076 μM | SANGER | ||
| UMC-11 | Growth Inhibition Assay | IC50=2.59868 μM | SANGER | ||
| COLO-679 | Growth Inhibition Assay | IC50=2.61233 μM | SANGER | ||
| A388 | Growth Inhibition Assay | IC50=2.65253 μM | SANGER | ||
| LB2518-MEL | Growth Inhibition Assay | IC50=2.65408 μM | SANGER | ||
| EW-13 | Growth Inhibition Assay | IC50=2.68768 μM | SANGER | ||
| MLMA | Growth Inhibition Assay | IC50=2.68856 μM | SANGER | ||
| HOP-92 | Growth Inhibition Assay | IC50=2.7011 μM | SANGER | ||
| NOMO-1 | Growth Inhibition Assay | IC50=2.71442 μM | SANGER | ||
| NCI-H810 | Growth Inhibition Assay | IC50=2.72198 μM | SANGER | ||
| 769-P | Growth Inhibition Assay | IC50=2.7228 μM | SANGER | ||
| SAS | Growth Inhibition Assay | IC50=2.765 μM | SANGER | ||
| M059J | Growth Inhibition Assay | IC50=2.78318 μM | SANGER | ||
| RD | Growth Inhibition Assay | IC50=2.79471 μM | SANGER | ||
| GT3TKB | Growth Inhibition Assay | IC50=2.83433 μM | SANGER | ||
| MZ7-mel | Growth Inhibition Assay | IC50=2.86502 μM | SANGER | ||
| KYSE-510 | Growth Inhibition Assay | IC50=2.89504 μM | SANGER | ||
| NCI-N87 | Growth Inhibition Assay | IC50=2.91807 μM | SANGER | ||
| MKN1 | Growth Inhibition Assay | IC50=3.00163 μM | SANGER | ||
| NCI-H2170 | Growth Inhibition Assay | IC50=3.00451 μM | SANGER | ||
| OVCAR-3 | Growth Inhibition Assay | IC50=3.02115 μM | SANGER | ||
| KLE | Growth Inhibition Assay | IC50=3.06812 μM | SANGER | ||
| LB771-HNC | Growth Inhibition Assay | IC50=3.09343 μM | SANGER | ||
| MC116 | Growth Inhibition Assay | IC50=3.11112 μM | SANGER | ||
| SCC-9 | Growth Inhibition Assay | IC50=3.11366 μM | SANGER | ||
| U031 | Growth Inhibition Assay | IC50=3.12423 μM | SANGER | ||
| LCLC-103H | Growth Inhibition Assay | IC50=3.23894 μM | SANGER | ||
| U-266 | Growth Inhibition Assay | IC50=3.27633 μM | SANGER | ||
| JVM-2 | Growth Inhibition Assay | IC50=3.32164 μM | SANGER | ||
| UACC-257 | Growth Inhibition Assay | IC50=3.46431 μM | SANGER | ||
| LB996-RCC | Growth Inhibition Assay | IC50=3.46502 μM | SANGER | ||
| BT-549 | Growth Inhibition Assay | IC50=3.50209 μM | SANGER | ||
| NCI-H526 | Growth Inhibition Assay | IC50=3.54158 μM | SANGER | ||
| RH-18 | Growth Inhibition Assay | IC50=3.61798 μM | SANGER | ||
| SW626 | Growth Inhibition Assay | IC50=3.71128 μM | SANGER | ||
| SK-N-AS | Growth Inhibition Assay | IC50=3.73247 μM | SANGER | ||
| IGR-1 | Growth Inhibition Assay | IC50=3.74248 μM | SANGER | ||
| NCI-H2291 | Growth Inhibition Assay | IC50=3.75336 μM | SANGER | ||
| NCI-H441 | Growth Inhibition Assay | IC50=3.82433 μM | SANGER | ||
| D-247MG | Growth Inhibition Assay | IC50=3.86031 μM | SANGER | ||
| COLO-320-HSR | Growth Inhibition Assay | IC50=3.91271 μM | SANGER | ||
| A253 | Growth Inhibition Assay | IC50=3.91436 μM | SANGER | ||
| HT55 | Growth Inhibition Assay | IC50=3.91773 μM | SANGER | ||
| MZ1-PC | Growth Inhibition Assay | IC50=3.95864 μM | SANGER | ||
| RERF-LC-MS | Growth Inhibition Assay | IC50=3.96525 μM | SANGER | ||
| SF268 | Growth Inhibition Assay | IC50=4.12881 μM | SANGER | ||
| RMG-I | Growth Inhibition Assay | IC50=4.21454 μM | SANGER | ||
| CFPAC-1 | Growth Inhibition Assay | IC50=4.21685 μM | SANGER | ||
| S-117 | Growth Inhibition Assay | IC50=4.22024 μM | SANGER | ||
| NCI-H2122 | Growth Inhibition Assay | IC50=4.30931 μM | SANGER | ||
| J82 | Growth Inhibition Assay | IC50=4.33441 μM | SANGER | ||
| CAL-72 | Growth Inhibition Assay | IC50=4.35477 μM | SANGER | ||
| GP5d | Growth Inhibition Assay | IC50=4.41298 μM | SANGER | ||
| UACC-62 | Growth Inhibition Assay | IC50=4.46545 μM | SANGER | ||
| MS-1 | Growth Inhibition Assay | IC50=4.49115 μM | SANGER | ||
| RCM-1 | Growth Inhibition Assay | IC50=4.5292 μM | SANGER | ||
| IST-SL1 | Growth Inhibition Assay | IC50=4.65359 μM | SANGER | ||
| SW756 | Growth Inhibition Assay | IC50=4.69135 μM | SANGER | ||
| HCC38 | Growth Inhibition Assay | IC50=4.71197 μM | SANGER | ||
| YAPC | Growth Inhibition Assay | IC50=4.71313 μM | SANGER | ||
| DK-MG | Growth Inhibition Assay | IC50=4.78112 μM | SANGER | ||
| HCC1937 | Growth Inhibition Assay | IC50=4.85125 μM | SANGER | ||
| OAW-28 | Growth Inhibition Assay | IC50=4.92435 μM | SANGER | ||
| MEG-01 | Growth Inhibition Assay | IC50=5.08328 μM | SANGER | ||
| GI-1 | Growth Inhibition Assay | IC50=5.23486 μM | SANGER | ||
| FADU | Growth Inhibition Assay | IC50=5.27837 μM | SANGER | ||
| CAPAN-1 | Growth Inhibition Assay | IC50=5.39432 μM | SANGER | ||
| TGBC11TKB | Growth Inhibition Assay | IC50=5.45786 μM | SANGER | ||
| DBTRG-05MG | Growth Inhibition Assay | IC50=5.5052 μM | SANGER | ||
| ONS-76 | Growth Inhibition Assay | IC50=5.55801 μM | SANGER | ||
| Ca-Ski | Growth Inhibition Assay | IC50=5.62566 μM | SANGER | ||
| COLO-741 | Growth Inhibition Assay | IC50=5.71995 μM | SANGER | ||
| HT-29 | Growth Inhibition Assay | IC50=5.80475 μM | SANGER | ||
| HCC1187 | Growth Inhibition Assay | IC50=5.81008 μM | SANGER | ||
| Capan-2 | Growth Inhibition Assay | IC50=5.95994 μM | SANGER | ||
| NCI-H630 | Growth Inhibition Assay | IC50=6.11441 μM | SANGER | ||
| COLO-678 | Growth Inhibition Assay | IC50=6.15092 μM | SANGER | ||
| D-502MG | Growth Inhibition Assay | IC50=6.17336 μM | SANGER | ||
| NB17 | Growth Inhibition Assay | IC50=6.24943 μM | SANGER | ||
| SK-MEL-24 | Growth Inhibition Assay | IC50=6.2649 μM | SANGER | ||
| NCI-SNU-5 | Growth Inhibition Assay | IC50=6.27118 μM | SANGER | ||
| D-392MG | Growth Inhibition Assay | IC50=6.33399 μM | SANGER | ||
| A498 | Growth Inhibition Assay | IC50=6.40302 μM | SANGER | ||
| OCI-AML2 | Growth Inhibition Assay | IC50=6.45445 μM | SANGER | ||
| HCC2157 | Growth Inhibition Assay | IC50=6.45616 μM | SANGER | ||
| C3A | Growth Inhibition Assay | IC50=6.52004 μM | SANGER | ||
| NCI-H1650 | Growth Inhibition Assay | IC50=6.70522 μM | SANGER | ||
| DU-145 | Growth Inhibition Assay | IC50=6.7703 μM | SANGER | ||
| COLO-829 | Growth Inhibition Assay | IC50=6.77873 μM | SANGER | ||
| LS-1034 | Growth Inhibition Assay | IC50=7.04412 μM | SANGER | ||
| HCC1954 | Growth Inhibition Assay | IC50=7.48134 μM | SANGER | ||
| KURAMOCHI | Growth Inhibition Assay | IC50=7.48533 μM | SANGER | ||
| Mo-T | Growth Inhibition Assay | IC50=7.51498 μM | SANGER | ||
| OE19 | Growth Inhibition Assay | IC50=7.65503 μM | SANGER | ||
| COR-L105 | Growth Inhibition Assay | IC50=7.71421 μM | SANGER | ||
| NCI-H2342 | Growth Inhibition Assay | IC50=7.71521 μM | SANGER | ||
| U-87-MG | Growth Inhibition Assay | IC50=8.03334 μM | SANGER | ||
| MKN28 | Growth Inhibition Assay | IC50=8.11515 μM | SANGER | ||
| HT-1197 | Growth Inhibition Assay | IC50=8.25907 μM | SANGER | ||
| ChaGo-K-1 | Growth Inhibition Assay | IC50=8.34245 μM | SANGER | ||
| NCI-H226 | Growth Inhibition Assay | IC50=8.44331 μM | SANGER | ||
| NCI-H2029 | Growth Inhibition Assay | IC50=9.06759 μM | SANGER | ||
| TE-11 | Growth Inhibition Assay | IC50=9.45588 μM | SANGER | ||
| ZR-75-30 | Growth Inhibition Assay | IC50=9.92634 μM | SANGER | ||
| SW837 | Growth Inhibition Assay | IC50=10.2293 μM | SANGER | ||
| NCI-H1651 | Growth Inhibition Assay | IC50=10.2326 μM | SANGER | ||
| NCI-H727 | Growth Inhibition Assay | IC50=10.4495 μM | SANGER | ||
| NCI-H358 | Growth Inhibition Assay | IC50=10.8365 μM | SANGER | ||
| NCI-H2087 | Growth Inhibition Assay | IC50=11.0434 μM | SANGER | ||
| FTC-133 | Growth Inhibition Assay | IC50=11.4051 μM | SANGER | ||
| LAN-6 | Growth Inhibition Assay | IC50=12.124 μM | SANGER | ||
| NCI-H1838 | Growth Inhibition Assay | IC50=12.5151 μM | SANGER | ||
| Calu-6 | Growth Inhibition Assay | IC50=14.1021 μM | SANGER | ||
| HCC70 | Growth Inhibition Assay | IC50=14.451 μM | SANGER | ||
| KARPAS-299 | Growth Inhibition Assay | IC50=15.2159 μM | SANGER | ||
| CAL-27 | Growth Inhibition Assay | IC50=15.3843 μM | SANGER | ||
| NCI-H82 | Growth Inhibition Assay | IC50=15.532 μM | SANGER | ||
| no-10 | Growth Inhibition Assay | IC50=15.938 μM | SANGER | ||
| U251 | Growth Inhibition Assay | IC50=16.3675 μM | SANGER | ||
| TE-9 | Growth Inhibition Assay | IC50=17.5166 μM | SANGER | ||
| TE-10 | Growth Inhibition Assay | IC50=19.0607 μM | SANGER | ||
| COLO-824 | Growth Inhibition Assay | IC50=20.9276 μM | SANGER | ||
| HuP-T3 | Growth Inhibition Assay | IC50=21.0748 μM | SANGER | ||
| KALS-1 | Growth Inhibition Assay | IC50=21.175 μM | SANGER | ||
| L-428 | Growth Inhibition Assay | IC50=21.4016 μM | SANGER | ||
| JAR | Growth Inhibition Assay | IC50=21.502 μM | SANGER | ||
| DoTc2-4510 | Growth Inhibition Assay | IC50=23.8475 μM | SANGER | ||
| ABC-1 | Growth Inhibition Assay | IC50=26.7957 μM | SANGER | ||
| MHH-NB-11 | Growth Inhibition Assay | IC50=33.3464 μM | SANGER | ||
| SW1463 | Growth Inhibition Assay | IC50=33.983 μM | SANGER | ||
| SW1417 | Growth Inhibition Assay | IC50=37.0952 μM | SANGER | ||
| NB12 | Growth Inhibition Assay | IC50=39.4655 μM | SANGER | ||
| NY | Growth Inhibition Assay | IC50=41.3201 μM | SANGER | ||
| TamR | Growth Inhibition Assay | IC50=18 nM | 24457069 | ||
| MCF7-X | Growth Inhibition Assay | IC50=24 nM | 24457069 | ||
| T47D-tamR | Growth Inhibition Assay | IC50=19 nM | 24457069 | ||
| Rh41 | Growth Inhibition Assay | IC50=30.7 nM | 21337679 | ||
| Rh18 | Growth Inhibition Assay | IC50=41.4 nM | 21337679 | ||
| Rh30 | Growth Inhibition Assay | IC50=14 nM | 21337679 | ||
| BT-12 | Growth Inhibition Assay | IC50=24.7 nM | 21337679 | ||
| CHLA-266 | Growth Inhibition Assay | IC50=1.1 nM | 21337679 | ||
| TC-71 | Growth Inhibition Assay | IC50=46.5 nM | 21337679 | ||
| CHLA-9 | Growth Inhibition Assay | IC50=15.3 nM | 21337679 | ||
| CHLA-10 | Growth Inhibition Assay | IC50=3.9 nM | 21337679 | ||
| CHLA-258 | Growth Inhibition Assay | IC50=10.4 nM | 21337679 | ||
| GBM2 | Growth Inhibition Assay | IC50=40.7 nM | 21337679 | ||
| NB-1643 | Growth Inhibition Assay | IC50=33.8 nM | 21337679 | ||
| NB-EBc1 | Growth Inhibition Assay | IC50=27.1 nM | 21337679 | ||
| CHLA-90 | Growth Inhibition Assay | IC50=34.5 nM | 21337679 | ||
| CHLA-136 | Growth Inhibition Assay | IC50=162.6 nM | 21337679 | ||
| NALM-6 | Growth Inhibition Assay | IC50=32.9 nM | 21337679 | ||
| COG-LL-317 | Growth Inhibition Assay | IC50=1.3 nM | 21337679 | ||
| RS4;11 | Growth Inhibition Assay | IC50=35 nM | 21337679 | ||
| MOLT-4 | Growth Inhibition Assay | IC50=8.6 nM | 21337679 | ||
| CCRF-CEM | Growth Inhibition Assay | IC50=4.1 nM | 21337679 | ||
| Kasumi-1 | Growth Inhibition Assay | IC50=1.4 nM | 21337679 | ||
| Karpas-299 | Growth Inhibition Assay | IC50=21.7 nM | 21337679 | ||
| Ramos-RA1 | Growth Inhibition Assay | IC50=8.2 nM | 21337679 | ||
| 点击查看更多细胞系数据 | |||||
生物活性
| 产品描述 | AZD8055是一种新型的，ATP竞争性mTOR抑制剂，在MDA-MB-468 细胞中IC50为0.8 nM，与作用于PI3K亚型和ATM/DNA-PK相比，具有优异的选择性（约1000倍）。AZD8055可诱导半胱天冬酶依赖的凋亡和自噬。Phase 1。 | ||||
|---|---|---|---|---|---|
| 特性 | AZD8055是第一种抑制两种类型mTOR蛋白的药物，被认为可能比之前mTOR抑制剂更有效。 | ||||
| 靶点 |
|
| 体外研究(In Vitro) | ||||
| 体外研究活性 | AZD8055作用于所有 PI3K亚型 (α, β, γ, δ) 和其他近PI3K激酶家族(ATM和DNA-PK)显示出低活性。AZD8055抑制mTORC1(p70S6K 和4E-BP1) ，mTORC2 (AKT) 和下游蛋白的磷酸化。AZD8055完全抑制4E-BP1抗Rapamycin 的T37/46 磷酸化位点, 导致明显抑制cap-dependent 转译作用。AZD8055有效抑制U87MG, A549和H838 细胞增殖， IC50分别为53, 50，和20 nM。AZD8055作用于H838和A549细胞，也诱导自体吞噬和增加LC3-II 水平。[1] AZD8055降低白血病细胞增殖和细胞周期进展, 降低白血病祖细胞的无性系生长，且在白血病细胞中诱导caspase依赖的细胞凋亡，但是作用于正常未成熟的CD34+ 细胞时不会产生这种诱导作用。[2] AZD8055 抑制儿科临床前期测试计划(PPTP)细胞系，IC50 为24.7 nM，且在EFS 分布时诱导产生明显区别。[3] | |||
|---|---|---|---|---|
| 激酶实验 | 抑制mTOR的细胞为基础的测定实验 | |||
| 通过高通量筛选细胞检测法，使用MDA-MB-468细胞，测定mTORC1 和mTORC2活性。用增加浓度的AZD8055处理细胞2小时。温育到最后时，细胞进行固定，冲洗，用p-Akt（S473）抗体和p-S6（S235/236)抗体探测。用激光扫描仪检测磷酸化水平。 | ||||
| 细胞实验 | 细胞系 | U87MG, A549，和H838 细胞 | ||
| 浓度 | 溶解在DMSO中，作为10 mM 储备液, 0.001-1.0 μM | |||
| 孵育时间 | 72到96小时 | |||
| 方法 | 用AZD8055处理细胞72到96小时， 用0.03 mg/mL Hoechst 33342染色细胞核，用1 μg/mL 吖啶橙染色酸性小囊泡染色。通过ArrayScan II平台在450和536纳米处获得图像，测量酸性小囊泡的百分数和细胞数量。进行LC3测评，用10 μg/mL e64d/抑肽素处理细胞30 到90分钟，然后和AZD8055温育。细胞溶解在冰上，通过免疫印迹法分析。 | |||
| 实验图片 | 检测方法 | 检测指标 | 实验图片 | PMID |
| Western blot | p-mTOR / p-AKT / p-4EBP1 / p-P70S6K / p-PRAS40 p-EGFR / EGFR p-FOXO1 / FOXO1 / p-FOXO3a / FOXO3a |
|
24457069 | |
| Immunofluorescence | p-4EBP1 / EIF4E / mTOR LC3B / p62 |
|
24600487 | |
| Growth inhibition assay | Cell viability |
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29263324 | |
| 体内研究(In Vivo) | ||
| 体内研究活性 | AZD8055 按2.5/10 mg/kg剂量作用于U87MG和A549移植瘤抑制pS6和pAKT，导致肿瘤生长受抑制。AZD8055按10/20 mg/kg剂量处理多种移植瘤包括U87MG, BT474c, A549, Calu-3, LoVo, SW620, PC3和MES-SA时，显示出明显的抗癌活性。[1] AZD8055诱导肿瘤体积下降约40%, 伴随着AKT, S6K，和SGK蛋白激酶磷酸化的切除。用AZD8055 (5mg/kg, 每天2次) 和SAHA (100 mg/kg/每天)处理PTEN+/−LKB1+/hypo 移植瘤，导致肿瘤生长全部受抑制，且对鼠mTORC1和mTORC2信号抑制没有副作用。[4] | |
|---|---|---|
| 动物实验 | Animal Models | U87MG, BT474c, A549, Calu-3, LoVo, SW620, PC3 and MES-SA U87-MG和A549细胞建立在无病原体，雌性裸鼠体内(nu/nu:Alpk)。 |
| Dosages | 2.5-20 mg/kg | |
| Administration | 口服饲喂，每天1到2次。 | |
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT01316809 | Completed | Glioblastoma Multiforme|Anaplastic Astrocytoma|Anaplastic Oligodendroglioma|Malignant Glioma|Brainstem Glioma |
National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) |
March 4 2011 | Phase 1 |
| NCT00999882 | Completed | Cancer|Advanced Hepatocellular Carcinoma |
AstraZeneca |
October 2009 | Phase 1 |
| NCT00973076 | Completed | Cancer|Solid Tumors|Advanced Solid Malignancies |
AstraZeneca |
August 2009 | Phase 1 |
| NCT00731263 | Completed | Solid Tumors |
AstraZeneca |
July 2008 | Phase 1 |
| NCT01194193 | Withdrawn | Cancer|Advanced Solid Tumours|Lymphomas |
AstraZeneca |
Phase 1 | |
化学信息&溶解度
| 分子量 | 465.54 | 分子式 | C25H31N5O4 |
| CAS号 | 1009298-09-2 | SDF | Download AZD8055 SDF |
| Smiles | CC1COCCN1C2=NC(=NC3=C2C=CC(=N3)C4=CC(=C(C=C4)OC)CO)N5CCOCC5C | ||
| 储存条件(自收到货起) | |||
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体外溶解度 |
DMSO : 93 mg/mL ( (199.76 mM)； DMSO吸湿会降低化合物溶解度，请使用新开封DMSO) Ethanol : 93 mg/mL Water : Insoluble |
摩尔浓度计算器 |
|
体内溶解度 现配现用，请按从左到右的顺序依次添加，澄清后再加入下一溶剂 |
动物体内配方计算器 | ||||
实验计算
动物体内配方计算器（澄清溶液）
第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）
mg/kg
g
μL
只
第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
计算结果：
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于μL DMSO溶液（母液浓度mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；
体内配方配制方法：取μL DMSO母液，加入μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入μL ddH2O，混匀澄清。
体内配方配制方法：取μL DMSO母液，加入μL Corn oil，混匀澄清。
注意：1. 首先保证母液是澄清的；
2.一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
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