AZD8055

For research use only. Not for use in humans.

目录号:S1555

AZD8055 Chemical Structure

CAS No. 1009298-09-2

AZD8055是一种新型的,ATP竞争性mTOR抑制剂,在MDA-MB-468 细胞中IC50为0.8 nM,与作用于PI3K亚型和ATM/DNA-PK相比,具有优异的选择性(约1000倍)。AZD8055可诱导半胱天冬酶依赖的凋亡和自噬。Phase 1。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1265.49 现货
RMB 712.53 现货
RMB 988.31 现货
RMB 3048.72 现货
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客户使用Selleck生产的AZD8055发表文献211篇:

产品安全说明书

mTOR抑制剂选择性比较

生物活性

产品描述 AZD8055是一种新型的,ATP竞争性mTOR抑制剂,在MDA-MB-468 细胞中IC50为0.8 nM,与作用于PI3K亚型和ATM/DNA-PK相比,具有优异的选择性(约1000倍)。AZD8055可诱导半胱天冬酶依赖的凋亡和自噬。Phase 1。
特性 AZD8055是第一种抑制两种类型mTOR蛋白的药物,被认为可能比之前mTOR抑制剂更有效。
靶点
mTOR (truncated) [1]
(MDA-MB-468 cells)
mTOR (full length) [1]
(MDA-MB-468 cells)
0.13 nM 0.8 nM
体外研究

AZD8055作用于所有 PI3K亚型 (α, β, γ, δ) 和其他近PI3K激酶家族(ATM和DNA-PK)显示出低活性。AZD8055抑制mTORC1(p70S6K 和4E-BP1) ,mTORC2 (AKT) 和下游蛋白的磷酸化。AZD8055完全抑制4E-BP1抗Rapamycin 的T37/46 磷酸化位点, 导致明显抑制cap-dependent 转译作用。AZD8055有效抑制U87MG, A549和H838 细胞增殖, IC50分别为53, 50,和20 nM。AZD8055作用于H838和A549细胞,也诱导自体吞噬和增加LC3-II 水平。[1] AZD8055降低白血病细胞增殖和细胞周期进展, 降低白血病祖细胞的无性系生长,且在白血病细胞中诱导caspase依赖的细胞凋亡,但是作用于正常未成熟的CD34+ 细胞时不会产生这种诱导作用。[2] AZD8055 抑制儿科临床前期测试计划(PPTP)细胞系,IC50 为24.7 nM,且在EFS 分布时诱导产生明显区别。[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
LU-139 MkH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HrbGlEPTB;MD6wNlM{OSEQvF2= NF3YdmM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
NCI-H720 Mn3qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjvTIxKSzVyPUCuNFI6OzhizszN NVPUeGNTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
KARPAS-45 MnzWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTBwMEOzO|Eh|ryP NIHMWGk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
EW-3 M4DJVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTvTWM2OD1yLkC0NFU3KM7:TR?= MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
SBC-1 NF3VZYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XiWmlEPTB;MD6wOFU5OSEQvF2= MnnZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
NCI-H209 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTxS5JLUUN3ME2wMlA2PDV|IN88US=> MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
EoL-1-cell MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkW5TWM2OD1yLkC2OVY6KM7:TR?= M2DOTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK|5USU6JRWK8M4E,
H9 Mk\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;V[FNKSzVyPUCuNFY3QTJizszN M3u3PFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK|5USU6JRWK8M4E,
AN3-CA MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPxdZBKSzVyPUCuNFc6PTFizszN M2L6fVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK|5USU6JRWK8M4E,
HH NHfoTG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\O[WlEPTB;MD6wPFAxQSEQvF2= MoC3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
KU812 M1\DWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYmwepdHUUN3ME2wMlA5ODR|IN88US=> M13LclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK|5USU6JRWK8M4E,
DU-4475 MkfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwMEiwOFch|ryP MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
CTV-1 NIDETWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGn1XYNKSzVyPUCuNFg3PDFizszN Mn;HQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
BV-173 NFvaco9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDqVZlKSzVyPUCuNFkxPjFizszN NGH5O4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
ES5 NIq0UplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwMEmzOUDPxE1? M4PNeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK|5USU6JRWK8M4E,
G-402 MmToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTBwMEm5PEDPxE1? Ml3jQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
MV-4-11 NH7GbYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTBwMUCzOFch|ryP NXTZcY12RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
NB69 NV[zWmxPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\s[3NKSzVyPUCuNVM2KM7:TR?= MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
EGI-1 MoTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwMUO1N|Eh|ryP MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
EW-18 M12wUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TVemlEPTB;MD6xOFA4OyEQvF2= MlrFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
ME-180 NXe2[oQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHSzbYtKSzVyPUCuNVQ3QDFizszN NHnmWFI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
D-283MED MnLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvHTWM2OD1yLkG0O|I{KM7:TR?= M2LvT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK|5USU6JRWK8M4E,
NB14 M3fodWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPzZmVkUUN3ME2wMlE3PDR5IN88US=> M1j2TVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK|5USU6JRWK8M4E,
Ramos-2G6-4C10 Mmj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTBwMU[5PFMh|ryP NYroOohwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
NBsusSR MnjXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3S4RWlEPTB;MD6xO|AyQSEQvF2= M2jxSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK|5USU6JRWK8M4E,
LAMA-84 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXZXHlKSzVyPUCuNVgxOzJizszN NIH0blE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
NCI-H1581 NIi4WmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrZ[WVKSzVyPUCuNVg6PjZizszN MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
A204 M{XERWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2qzXGlEPTB;MD6xPFk4KM7:TR?= M2S4WFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK|5USU6JRWK8M4E,
A549 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDRVXpPUUN3ME2wMlE6PTVizszN MmTPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
CAL-51 M3[1N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXKe5hKSzVyPUCuNVk3PTFizszN NXjxVIl1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
NKM-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELpemlKSzVyPUCuNlAxOjlizszN MlLkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
LoVo NYewSJpCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3PZ2JvUUN3ME2wMlIxOjB{IN88US=> MlvzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
HAL-01 NH\3bGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn70TWM2OD1yLkKwNlk4KM7:TR?= NYK4UlBGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
HCC2218 NFTWc|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLFTVA3UUN3ME2wMlIxPjh6IN88US=> MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
BEN NV;CUIdsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfHSHVTUUN3ME2wMlIyOjl|IN88US=> NHLycIQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
LC-2-ad NF;Fd|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGSyNnlKSzVyPUCuNlIxQDRizszN Mlu5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
LXF-289 NVXhOnBYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDwTWM2OD1yLkK1NFQyKM7:TR?= NEDhcZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
HGC-27 M4DZVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\wTWM2OD1yLkK2OFE1KM7:TR?= NV:3dZVlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
LK-2 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHre4I1UUN3ME2wMlI3QDJ2IN88US=> NVfJVnFiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
CTB-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjBOnhHUUN3ME2wMlI4OjF3IN88US=> M{XF[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK|5USU6JRWK8M4E,
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ES7 M{P5cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTBwMkezPFMh|ryP NIrLWFI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
MG-63 Mlm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7qTWM2OD1yLkK3OFA4KM7:TR?= MmSyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
T47D MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwMke0O|Uh|ryP NY\YV4dURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
RPMI-8226 NXm1[IUxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4KzT2lEPTB;MD6yPFU5QSEQvF2= NVXkSFZ5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
NCI-H292 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvNfGpKSzVyPUCuNlkyPjRizszN MlHVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
HT M{ntbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PCOWlEPTB;MD6yPVM5KM7:TR?= NV\mcnBtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
A3-KAW MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPqTJhKSzVyPUCuNlk4PCEQvF2= Mly2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
LB2241-RCC MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLubGdKSzVyPUCuN|AyQThizszN NFvCTIw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
BB65-RCC MnTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwM{C4NFUh|ryP MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
G-401 M3r4cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{e2PGlEPTB;MD6zNFk5PiEQvF2= M3jhVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK|5USU6JRWK8M4E,
TYK-nu MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfHSIR4UUN3ME2wMlMyQDZ2IN88US=> M13VTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK|5USU6JRWK8M4E,
NCI-SNU-1 M3HrNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwM{KzN|Eh|ryP M4TXXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK|5USU6JRWK8M4E,
CHL-1 Mnf6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1uwTWlEPTB;MD6zNlcxOyEQvF2= MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
P30-OHK MoKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nzTWlEPTB;MD6zNlcxPSEQvF2= NUfnN5BTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
PA-1 MkX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTBwM{O2NVkh|ryP M1LSe|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK|5USU6JRWK8M4E,
LB1047-RCC M1jNN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTBwM{SwOFch|ryP NGHvTGo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
EM-2 NHPxb4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfvTWM2OD1yLkO0NVg5KM7:TR?= MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
VA-ES-BJ NGjsRY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo[wTWM2OD1yLkO0NlY5KM7:TR?= MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
NCI-H520 Mn;oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmqyTWM2OD1yLkO0PFM1KM7:TR?= M2q3OFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK|5USU6JRWK8M4E,
ECC10 NGLPSIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LaTGlEPTB;MD6zOVA{PSEQvF2= MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
LNCaP-Clone-FGC NIr6T5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwM{WzNVQh|ryP M1vjblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK|5USU6JRWK8M4E,
ES8 M2[zVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDqXppKSzVyPUCuN|Y2PTNizszN MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
HuO-3N1 NWD2TG1FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\uNWlEPTB;MD6zPFM4QSEQvF2= M3\kXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK|5USU6JRWK8M4E,
L-363 M3j4fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mom0TWM2OD1yLkO5NFI3KM7:TR?= M3\HOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK|5USU6JRWK8M4E,
SK-LU-1 M4X5b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3uw[WlEPTB;MD6zPVIxQCEQvF2= NGXuXWk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
MCF7 NXi1NVh6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fQemlEPTB;MD60NFU{KM7:TR?= MkCxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
HuO9 NGjsW3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjKTWM2OD1yLkSwOlY4KM7:TR?= NYjPRWw{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
BHT-101 Ml\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPMXpFKSzVyPUCuOFA4QDdizszN NHf6OJM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
MZ2-MEL MljaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHLTWM2OD1yLkSwPFgzKM7:TR?= MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
NOS-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XHSGlEPTB;MD60NVA4PCEQvF2= NHrsVoc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
NEC8 NX7wWVBjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\aSYFYUUN3ME2wMlQyPjl3IN88US=> NH;KTXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
COR-L88 M{jSd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPqTWM2OD1yLkSyNlY4KM7:TR?= MkLqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
MFM-223 NIf0WnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M362WWlEPTB;MD60NlYyPyEQvF2= MofpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
HSC-3 M37QWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{G4W2lEPTB;MD60NlkxQCEQvF2= NHzZbJk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
OVCAR-5 NV\wfG5yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEG3So5KSzVyPUCuOFI6OzNizszN M{\yO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK|5USU6JRWK8M4E,
MFE-280 NXjQXWUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XGcWlEPTB;MD60N|A{OiEQvF2= Mor4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
KP-N-YS MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTBwNEOwO{DPxE1? M4DUV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK|5USU6JRWK8M4E,
EPLC-272H M4ntV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTBwNEOwO|ch|ryP MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
KE-37 NF3KbWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjKOHhKSzVyPUCuOFMzPDdizszN MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
HuH-7 M3\6[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLvTWM2OD1yLkSzN|czKM7:TR?= NFfUZVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
CHP-212 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTBwNEO2PVch|ryP M4DmS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK|5USU6JRWK8M4E,
SK-MES-1 NXPJR3BIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHvbVd5UUN3ME2wMlQ{QDR6IN88US=> M4\GSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK|5USU6JRWK8M4E,
SJSA-1 NV;U[WtQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7mSVhsUUN3ME2wMlQ1PTV2IN88US=> MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
QIMR-WIL NVz5cY16T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFP0dGRKSzVyPUCuOFUyPSEQvF2= NUixV214RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
ES4 M1\0O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjMTWM2OD1yLkS1N|M3KM7:TR?= NYL3UXZHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
TI-73 NFnNSXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;oZ3U4UUN3ME2wMlQ2Pjh4IN88US=> NWn3cGpCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
COLO-684 MlrCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTBwNEW3NlYh|ryP Mlj4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
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CAL-27 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY[5N4pJUUN3ME2xOU4{QDR|IN88US=> MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
NCI-H82 M4TCb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHe2XYtKSzVyPUG1MlU{OiEQvF2= MlP1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
no-10 Mn\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTF3LkmzPEDPxE1? Mm\IQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
U251 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rnRWlEPTB;MU[uN|Y4PSEQvF2= M1[3clxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK|5USU6JRWK8M4E,
TE-9 NF7uPFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2joPWlEPTB;MUeuOVE3PiEQvF2= NUnaNG5zRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
TE-10 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTF7LkC2NFch|ryP NI\LVpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
COLO-824 NGX0WW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTJyLkmyO|Yh|ryP NWjxPWRnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
HuP-T3 M3O0S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn6xTWM2OD1{MT6wO|Q5KM7:TR?= NELMcGc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
KALS-1 MlvNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnaTWM2OD1{MT6xO|Uh|ryP NIrnZlI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
L-428 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTJzLkSwNVYh|ryP NYjDNHZVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
JAR NYj2SGd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUn0UVFCUUN3ME2yNU42ODJizszN M2r0ZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK|5USU6JRWK8M4E,
DoTc2-4510 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnBTWM2OD1{Mz64OFc2KM7:TR?= M3HZWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK|5USU6JRWK8M4E,
ABC-1 M1mxS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTJ4Lke5OVch|ryP NWn5[nVZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
MHH-NB-11 NGTyZ21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\GbWlEPTB;M{OuN|Q3PCEQvF2= MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
SW1463 M{eydWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTN|Lkm4N{DPxE1? M2DDeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK|5USU6JRWK8M4E,
SW1417 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTN5LkC5OVIh|ryP MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
NB12 NIDwR|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fEfGlEPTB;M{muOFY2PSEQvF2= NYH1UXFxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
NY NXzjdm5sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzZW5F6UUN3ME20NU4{OjBzIN88US=> NGfCPVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
H1048 MWjBdI9xfG:|aYOgRZN{[Xl? NF33NFc2ODBibl2= M3zEOFczKGh? NFS1W2dvcGGwY3XzJGFDXC1{NkRihLNqdmS3Y3XkJIFxd3C2b4Ppdy=> NGTSdVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUezO|U1Oid-MkW3N|c2PDJ:L3G+
H86 NFPYcIZCeG:ydH;zbZMhSXO|YYm= MV[1NFAhdk1? NXnrOmg4PzJiaB?= NHrPSIdvcGGwY3XzJGFDXC1{NkRihLNqdmS3Y3XkJIFxd3C2b4Ppdy=> NUnmWmUyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3N|c2PDJpPkK1O|M4PTR{PD;hQi=>
H196 MYHBdI9xfG:|aYOgRZN{[Xl? MXS1NFAhdk1? M4DNRlczKGh? NGjkTGNvcGGwY3XzJGFDXC1{NkRihLNqdmS3Y3XkJIFxd3C2b4Ppdy=> MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd|N{W0Nkc,OjV5M{e1OFI9N2F-
H446 MYHBdI9xfG:|aYOgRZN{[Xl? NG\MdJk2ODBibl2= MVy3NkBp NEjTPXVvcGGwY3XzJGFDXC1{NkRihLNqdmS3Y3XkJIFxd3C2b4Ppdy=> MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd|N{W0Nkc,OjV5M{e1OFI9N2F-
TFK-1 MnHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HEU|czKGh? MmjqSG1UVw>? NETmbJBKSzVyPUS3JI5O MmDPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVzNUKyOFQoRjJ3MUWyNlQ1RC:jPh?=
EGI-1 NEXjVmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXS3NkBp NYq4ZWk1TE2VTx?= M{PsSWlEPTB;NUOgcm0> NILtfGY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUG1NlI1PCd-MkWxOVIzPDR:L3G+
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U937 NGH0doxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLJNE4zKM7:TR?= M4TiU|Q5KGh? NWrUSHFP\W6qYX7j[ZMh[2WubDDndo94fGhiaX7obYJqfGmxbjDpcoR2[2WmIHL5JJNmdHWvZYTpcolj NWnRdHFERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3N|k{QTNpPkK0O|M6Ozl|PD;hQi=>
MOLM13 NYLWdIo3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofUNE4zKM7:TR?= M4HGNFQ5KGh? MkPS[Y5p[W6lZYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCrbnT1Z4VlKGK7IIPlcJVu\XSrbnni NYniW41MRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3N|k{QTNpPkK0O|M6Ozl|PD;hQi=>
MCF7 NVq3[ZlHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HBN|IxKG6P M4nqSVczKGh? MmfXSmJU MlXMdoVlfWOnczD0bIUhWEWOUEGtcYVlcWG2ZXSgbY5kemWjc3WgbY4h[2WubDD2bYFjcWyrdIm= M1jtN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2Nki4NFQ3Lz5{NE[4PFA1PjxxYU6=
TamR NGTNd3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3sZ5pbUUN3ME2xPQKBkW6P NUPMRnZiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS0OVcxPjlpPkK0OFU4ODZ7PD;hQi=>
MCF7-X  M3TJfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTJ2IH7N M3G2XlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEW3NFY6Lz5{NES1O|A3QTxxYU6=
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293T  M3\jfWZ2dmO2aX;uJGF{e2G7 NUn1ZohEOjBibl2= M2\iTlMhcA>? NXf0dpF4\Gm|coXweJMhSWu2LX3l[IlifGWmIGTJSk1KSSC|dHHibYxqfHluIITyZY5{dG:lYYTpc44tKGGwZDDhZ5Rqfmm2eR?= NHPETpU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO2N|Q1QSd-MkSzOlM1PDl:L3G+
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Huh7  NELCWGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DTUFUuOTByIH7N MYmwMVI1KGh? M1jRXmROW09? NUXGU5RvcW6lcnXhd4V{KGOnbHyg[IVifGhiaX6gZUBkd26lZX70doF1cW:wLTDhcoQhfGmvZT3k[ZBmdmSnboSgcYFvdmW{ NW\1W3M{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyPVc{ODBpPkK0Nlk4OzByPD;hQi=>
Hep3B  MkDPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\nOU0yODBibl2= NVmxN5czOC1{NDDo MXnEUXNQ M4ra[olv[3KnYYPld{Bk\WyuIHTlZZRpKGmwIHGgZ49v[2WwdILheIlwdi1iYX7kJJRqdWVvZHXw[Y5l\W62IH3hco5meg>? NH:3NJY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEK5O|MxOCd-MkSyPVc{ODB:L3G+
Huh7  NYjQXVd4TnWwY4Tpc44hSXO|YYm= NWjwNmN3OTByIH7N NILQUHAyOiCq MV\EUXNQ MV7pcoR2[2W|IHH1eI9xcGGpedMg NE\2VI09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEK5O|MxOCd-MkSyPVc{ODB:L3G+
U87-MG  MlTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYG3NkBp MXnHTVUx6oDLPfMAjVc6KG6PwrC= NWPOSVZQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyOFk3PDBpPkK0NlQ6PjRyPD;hQi=>
 L3.6pl NGr2dmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\aSWozOSEQvF2= NIXPXos4OiCq MULpcohq[mm2czD0bIUh[2WubDDndo94fGhiY3;tZolv\WRid3n0bEBDVVNvN{e3OlA4 M4n4V|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MkOzN|k6Lz5{NEKzN|M6QTxxYU6=
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Hep-2 NG[1PXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLlN5cxNjBzLUGg{txO NXPkOYo6OTJvOU[gbC=> MkXVbY5kemWjc3XzJINmdGxiZHXheIghcW5iYTDjc45k\W62cnH0bY9vNSCjbnSgeIlu\S2mZYDlcoRmdnRibXHucoVz Mmq4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzMEO3OFkoRjJ2MUCzO|Q6RC:jPh?=
SCC-9 NFjwOpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTRNJRbOC5yMT2xJO69VQ>? NGeyR5AyOi17NjDo MlnubY5kemWjc3XzJINmdGxiZHXheIghcW5iYTDjc45k\W62cnH0bY9vNSCjbnSgeIlu\S2mZYDlcoRmdnRibXHucoVz NFj4Smw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEGwN|c1QSd-MkSxNFM4PDl:L3G+
Hep-2 NH3ZSHdHfW6ldHnvckBCe3OjeR?= MVqwMlEwOC53IN88US=> MlrwNlQhcA>? NES0bY1jdG:la4OgcXRQWkNzIHHu[EBuXE:UQ{KgZYN1cX[jdHnvci=> NUHTfmF[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSxNFM4PDlpPkK0NVA{PzR7PD;hQi=>
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PANC-1 NHr1PXNCeG:ydH;zbZMhSXO|YYm= MUG1NFAhdk1? M{fZO|Q5KGh? NIrBcGR{\W6|aYTpfoV{KHCjbnPy[YF1cWNiY3HuZ4VzKGOnbHzzJJRwKHKjZHnveIhmemGyeR?= MkfEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6OE[yPVQoRjJ|OEi2Nlk1RC:jPh?=
RMG2 NFXHU2ZCeG:ydH;zbZMhSXO|YYm= Mn;2NU0yODByIH7N M2i4T|czKGh? NXHocIN6TkKV M3jMOolvcGmkaYTzJJRp\SClZXzsJJZq[WKrbHn0fUBkd26lZX70doF1cW:wIHTldIVv\GWwdHz5 NEfzUFM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[xOVY{OSd-MkO2NVU3OzF:L3G+
HAC2 MnXmRZBweHSxc3nzJGF{e2G7 NX7JfGVrOS1zMECwJI5O MnzVO|IhcA>? MmHYSmJU M4HRNolvcGmkaYTzJJRp\SClZXzsJJZq[WKrbHn0fUBkd26lZX70doF1cW:wIHTldIVv\GWwdHz5 MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZzNU[zNUc,OjN4MUW2N|E9N2F-
HT-29 M{LiZWFxd3C2b4Ppd{BCe3OjeR?= MlnoNUDPxE1? NFjaTpA4OiCq NHjkdWVifHSnboXheIV{KDVvRmWtbY5lfWOnZDDj[YxtKGSnYYTo MnXDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NEmxNlEoRjJzOUS5NVIyRC:jPh?=
DLD1 MXfBdI9xfG:|aYOgRZN{[Xl? NEXrdHYyKM7:TR?= NUfJVFBjPzJiaB?= M1[3[YF1fGWwdXH0[ZMhPS2IVT3pcoR2[2WmIHPlcIwh\GWjdHi= M4rsTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOUS5NVIyLz5{MUm0PVEzOTxxYU6=
HT-29 NXziXYg4TnWwY4Tpc44hSXO|YYm= NYSxOYd[OSEQvF2= MVG3NkBp NF7idWJqdmS3Y3XzJIF2fG:yaHHnfUB1dyClb37m[ZIh[3m2b4Dyc5Rm[3Srb36= NWnwUmd4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OFkyOjFpPkKxPVQ6OTJzPD;hQi=>
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CHLA-9 NIHMdXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTF3LkOgcm0> NVrWSIJRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzN|c3PzlpPkKxN|M4Pjd7PD;hQi=>
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CHLA-258 M{HpXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\mWmlEPTB;MUCuOEBvVQ>? MoqwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF|M{e2O|koRjJzM{O3Olc6RC:jPh?=
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NB-1643 NHr0bXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV30e4g2UUN3ME2zN{45KG6P NYm4dFh6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzN|c3PzlpPkKxN|M4Pjd7PD;hQi=>
NB-EBc1 NVfzbFE4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTDTWM2OD1{Nz6xJI5O MojWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF|M{e2O|koRjJzM{O3Olc6RC:jPh?=
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MOLT-4 NHXhV4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{n3UGlEPTB;OD62JI5O NGfBR249[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUOzO|Y4QSd-MkGzN|c3Pzl:L3G+
CCRF-CEM M1m3cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoH2TWM2OD12LkGgcm0> MnXwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF|M{e2O|koRjJzM{O3Olc6RC:jPh?=
Kasumi-1 M{LDfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHFSVRjUUN3ME2xMlQhdk1? NGS1eZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUOzO|Y4QSd-MkGzN|c3Pzl:L3G+
Karpas-299 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HhWGlEPTB;MkGuO{BvVQ>? MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTN|N{[3PUc,OjF|M{e2O|k9N2F-
Ramos-RA1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRThwMjDuUS=> MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTN|N{[3PUc,OjF|M{e2O|k9N2F-
H838 NX31doxsTnWwY4Tpc44hSXO|YYm= MWKxJO69VQ>? NYrqRVRlPDhiaB?= NV;P[YZPcW6mdXPld{Bk\WyuIHH1eI9xcGGpeR?= NE\5XIU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEO2OFEyOyd-MkCzOlQyOTN:L3G+
H838 NXTnSpFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzFNE0{KM7:TR?= NU[5eYhUPzJiaB?= Mo\xbY5lfWOnczDndo94fGhiaX7obYJqfGmxbjDhcoQh[XW2b4DoZYd6 NXfzR2NNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCwNlg5PTRpPkKwNFI5QDV2PD;hQi=>
A549  Mmr5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3exVVAuOyEQvF2= MX23NkBp NV\Uc|N2cW6mdXPld{Boem:5dHigbY5pcWKrdHnvckBidmRiYYX0c5Bp[We7 NXGxNVRqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCwNlg5PTRpPkKwNFI5QDV2PD;hQi=>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-mTOR / p-AKT / p-4EBP1 / p-P70S6K / p-PRAS40; 

PubMed: 24457069     


Western blots of 70% confluent TamR (A) and MCF7-X (B) cells treated for 15 minutes to 24 hours with AZD8055 (0 to 100 nM). Blots were probed with phospho- and total antibodies for mTORC1 and two signalling pathways. In both cell lines mTORC1 and mTORC2 s䲧疝Ỵ疞㧀疜膉痘 瘿삨ՂᾰƌՂĀ 㺣痖帉痖Ѐ瑖堘𢡄빢᎒ՂĀ鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙

p-EGFR / EGFR; 

PubMed: 25654224     


PANC-1 cells were treated with AZD8055 for the indicated hours and EGFR (T/P), AKT (T/P) and ribosomal protein S6 (S6) (T/P) proteins were examined by western-blot;

p-FOXO1 / FOXO1 / p-FOXO3a / FOXO3a ; 

PubMed: 25654224     


PANC-1 cells were transfected with FoxO1/FoxO3a siRNAs and treated with AZD8055 for 1 h, then AKT (T/P), FoxO1 (T/P), FoxO3a (T/P) and EGFR (T/P) proteins were examined by western-blot.

24457069 25654224
Immunofluorescence
p-4EBP1 / EIF4E / mTOR; 

PubMed: 24600487     


(C) Hoechst 33258 staining of Hep-2 cells after treatment with AZD8055 for 24 hours were shown. The cells were fixed and immunereacted with anti-mTOR antibody followed by incubation with Alexa 488-labeled secondary antibody (C-F). Images were taken by a c䲧疝Ỵ疞㧀疜膉痘 瘿삨ՂᾰƌՂĀ 㺣痖帉痖Ѐ瑖堘𢡄빢᎒ՂĀ鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ�෋䐺痖暼瘿�෋ᾰƌ �෋à㺣痖�෋€𢡄�෋€䀷痗�෋౴�෋㵶痗�෋뺖᎒泌Itemセ᎒Count﫨呂�෋猴፲�෋፲씢痗猸፲髸莤䥷堙᎒セ᎒�堞ﻮ᎒፲露𢡄堚،齃礤v�堞ﻮ᎒猢Wセ᎒䨼Ą鹿齃殺獸W戀醙玛W戀ⶰ໯齃礤v 玚W玢Wⶰ໯﫰礌vtЉᔈැ鲬౴᥊疜犈፲Eo狜፲艘ᎂ艘ᎂ⩈̎䥠̌씢痗狠፲붖᎒i變ﱘ﫰﬐먙堘붖᎒狠፲i變ﱘ﫰먰堘ﱘ붖᎒�堞봆᎒릎堘붖᎒i꣩쯟巰痗ꣵ쯟巰痗Љ镴౴￿￿嶴痗Љ镨౴ᔈැ竗ᔈැ屷痗W竗尊痗

LC3B / p62 ; 

PubMed: 30337536     


Immunofluorescence staining of U87 and U251 GICs, which treated by DMSO, AZD8055 (0.3 μM) and rapamycin (3 μM). The nuclei were stained with DAPI and the antibody against LC3B and p62. Images were captured by laser confocal microscope ( × 400), scale bar 䲧疝Ỵ疞

24600487 30337536
Growth inhibition assay
Cell viability ; 

PubMed: 29263324     


Growth for the indicated cell lines was assessed after 72 h of treatment with AZD8055 (0–250 nM). Results are expressed as a percentage of cell number relative to the DMSO-treated control cells a.

29263324
体内研究 AZD8055 按2.5/10 mg/kg剂量作用于U87MG和A549移植瘤抑制pS6和pAKT,导致肿瘤生长受抑制。AZD8055按10/20 mg/kg剂量处理多种移植瘤包括U87MG, BT474c, A549, Calu-3, LoVo, SW620, PC3和MES-SA时,显示出明显的抗癌活性。[1] AZD8055诱导肿瘤体积下降约40%, 伴随着AKT, S6K,和SGK蛋白激酶磷酸化的切除。用AZD8055 (5mg/kg, 每天2次) 和SAHA (100 mg/kg/每天)处理PTEN+/−LKB1+/hypo 移植瘤,导致肿瘤生长全部受抑制,且对鼠mTORC1和mTORC2信号抑制没有副作用。[4]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[1]
- 合并

抑制mTOR的细胞为基础的测定实验:

通过高通量筛选细胞检测法,使用MDA-MB-468细胞,测定mTORC1 和mTORC2活性。用增加浓度的AZD8055处理细胞2小时。温育到最后时,细胞进行固定,冲洗,用p-Akt(S473)抗体和p-S6(S235/236)抗体探测。用激光扫描仪检测磷酸化水平。
细胞实验:[1]
- 合并
  • Cell lines: U87MG, A549,和H838 细胞
  • Concentrations: 溶解在DMSO中,作为10 mM 储备液, 0.001-1.0 μM
  • Incubation Time: 72到96小时
  • Method: 用AZD8055处理细胞72到96小时, 用0.03 mg/mL Hoechst 33342染色细胞核,用1 μg/mL 吖啶橙染色酸性小囊泡染色。通过ArrayScan II平台在450和536纳米处获得图像,测量酸性小囊泡的百分数和细胞数量。进行LC3测评,用10 μg/mL e64d/抑肽素处理细胞30 到90分钟,然后和AZD8055温育。细胞溶解在冰上,通过免疫印迹法分析。
    (Only for Reference)
动物实验:[1]
- 合并
  • Animal Models: U87MG, BT474c, A549, Calu-3, LoVo, SW620, PC3 and MES-SA U87-MG和A549细胞建立在无病原体,雌性裸鼠体内(nu/nu:Alpk)。
  • Dosages: 2.5-20 mg/kg
  • Administration: 口服饲喂,每天1到2次。
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 50 mg/mL warmed (107.4 mM)
Ethanol 3 mg/mL (6.44 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
4% DMSO+30% PEG 300+ddH2O
5mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 465.54
化学式

C25H31N5O4

CAS号 1009298-09-2
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01316809 Completed Drug: AZD8055 Glioblastoma Multiforme|Anaplastic Astrocytoma|Anaplastic Oligodendroglioma|Malignant Glioma|Brainstem Glioma National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) March 4 2011 Phase 1
NCT00999882 Completed Drug: AZD8055 Cancer|Advanced Hepatocellular Carcinoma AstraZeneca October 2009 Phase 1
NCT00973076 Completed Drug: AZD8055 Cancer|Solid Tumors|Advanced Solid Malignancies AstraZeneca August 2009 Phase 1
NCT00731263 Completed Drug: AZD8055 Solid Tumors AstraZeneca July 2008 Phase 1
NCT01194193 Withdrawn Drug: AZD8055 Cancer|Advanced Solid Tumours|Lymphomas AstraZeneca Phase 1

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID