AZD8055

For research use only. Not for use in humans.

目录号：S1555

CAS No. 1009298-09-2

AZD8055是一种新型的，ATP竞争性mTOR抑制剂，在MDA-MB-468 细胞中IC50为0.8 nM，与作用于PI3K亚型和ATM/DNA-PK相比，具有优异的选择性（约1000倍）。AZD8055可诱导半胱天冬酶依赖的凋亡和自噬。Phase 1。

规格

价格

库存

购买数量

10mM (1mL in DMSO)	RMB 1265.49	现货
5mg	RMB 712.53	现货
10mg	RMB 988.31	现货
50mg	RMB 3048.72	现货
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客户使用Selleck生产的AZD8055发表文献207篇：

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Mol Cell, 2019, 10.1016/j.molcel.2019.10.016

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Cancers (Basel), 2019, 11(10)

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J Immunol, 2016, 196(10):4390-9

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PLoS One, 2015, 10(11):e0143357

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J Clin Invest, 2014, 10.1172/JCI73935

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Cancer Res, 2014, 74(10):2846-56

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Oncol Rep, 2014, 31(2):649-56

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Oncotarget, 2014,

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Blood, 2013, 121(18):3619-30

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EMBO J, 2013, 28;32(17):2377-91

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Cancer Res, 2013, 73(11):3402-11

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Mol Cancer, 2013, 12:81

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Autophagy, 2012, 9(1):74-92

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Biochem Pharmacol, 2012, 83(9):1183-94

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产品安全说明书

mTOR抑制剂选择性比较

生物活性

产品描述

特性

AZD8055是第一种抑制两种类型mTOR蛋白的药物，被认为可能比之前mTOR抑制剂更有效。

靶点

mTOR (truncated) ^[1] (MDA-MB-468 cells)	mTOR (full length) ^[1] (MDA-MB-468 cells)
0.13 nM	0.8 nM

体外研究

AZD8055作用于所有 PI3K亚型 (α, β, γ, δ) 和其他近PI3K激酶家族(ATM和DNA-PK)显示出低活性。AZD8055抑制mTORC1(p70S6K 和4E-BP1) ，mTORC2 (AKT) 和下游蛋白的磷酸化。AZD8055完全抑制4E-BP1抗Rapamycin 的T37/46 磷酸化位点, 导致明显抑制cap-dependent 转译作用。AZD8055有效抑制U87MG, A549和H838 细胞增殖， IC50分别为53, 50，和20 nM。AZD8055作用于H838和A549细胞，也诱导自体吞噬和增加LC3-II 水平。^[1] AZD8055降低白血病细胞增殖和细胞周期进展, 降低白血病祖细胞的无性系生长，且在白血病细胞中诱导caspase依赖的细胞凋亡，但是作用于正常未成熟的CD34+ 细胞时不会产生这种诱导作用。^[2] AZD8055 抑制儿科临床前期测试计划(PPTP)细胞系，IC50 为24.7 nM，且在EFS 分布时诱导产生明显区别。^[3]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
LU-139	NHr0Z2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MkfRTWM2OD1yLkCyN\|MyKM7:TR?=	MmnhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
NCI-H720	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2HieGlEPTB;MD6wNlk{QCEQvF2=	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
KARPAS-45	M33Hbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFPPWZBKSzVyPUCuNFM{PzFizszN	NFzYZ2Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
EW-3	NVv1Z29tT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MmTWTWM2OD1yLkC0NFU3KM7:TR?=	M1\pSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
SBC-1	NGjIR\|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWDJR\|UxRTBwMES1PFEh\|ryP	NH3KbVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
NCI-H209	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NXOxR\|lFUUN3ME2wMlA2PDV\|IN88US=>	NF;VeVA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
EoL-1-cell	MkK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MkjUTWM2OD1yLkC2OVY6KM7:TR?=	MkLJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
H9	MmfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mnz2TWM2OD1yLkC2OlkzKM7:TR?=	NXHQUJJCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
AN3-CA	Ml;oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mm\hTWM2OD1yLkC3PVUyKM7:TR?=	NH;xems9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
HH	NE\vS4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NG\JTmpKSzVyPUCuNFgxODlizszN	MkTEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
KU812	MoTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2i3T2lEPTB;MD6wPFA1OyEQvF2=	NXLNNmVGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
DU-4475	M1zqSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NETZRXJKSzVyPUCuNFgxPDdizszN	NIr6ZYc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
CTV-1	NGXYOlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXXrd3NuUUN3ME2wMlA5PjRzIN88US=>	Mn73QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
BV-173	NYrCO5RiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NELuZ2JKSzVyPUCuNFkxPjFizszN	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
ES5	Mkm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MUnJR\|UxRTBwMEmzOUDPxE1?	NV;yZ2xIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
G-402	NHPxVnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mn3lTWM2OD1yLkC5PVgh\|ryP	MmL1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
MV-4-11	NILKNWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUXkS4dsUUN3ME2wMlExOzR5IN88US=>	MkLxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
NB69	NYS1RZdGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MkWzTWM2OD1yLkGzOUDPxE1?	M3rzflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
EGI-1	M1jFPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NH7CUVNKSzVyPUCuNVM2OzFizszN	NH7ueIE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
EW-18	MoHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYDFWG9KUUN3ME2wMlE1ODd\|IN88US=>	MlnJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
ME-180	NUf3cFJGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NYS2RpZWUUN3ME2wMlE1PjhzIN88US=>	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
D-283MED	NH\TXoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NHLQR5RKSzVyPUCuNVQ4OjNizszN	Mlr4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
NB14	NFr2cHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1PNe2lEPTB;MD6xOlQ1PyEQvF2=	NYfYe3JkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
Ramos-2G6-4C10	NVLmNG57T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MUnJR\|UxRTBwMU[5PFMh\|ryP	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
NBsusSR	M2jHPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MX\JR\|UxRTBwMUewNVkh\|ryP	M2Hoc\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
LAMA-84	NXT2dmVpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MWXJR\|UxRTBwMUiwN\|Ih\|ryP	M{nHdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
NCI-H1581	M{HHTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mom0TWM2OD1yLkG4PVY3KM7:TR?=	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
A204	M{jafGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NXq1SHR5UUN3ME2wMlE5QTdizszN	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
A549	NH:1d2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWDJR\|UxRTBwMUm1OUDPxE1?	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
CAL-51	NGrU[49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NF;jW2lKSzVyPUCuNVk3PTFizszN	NUHMblJORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
NKM-1	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUPJR\|UxRTBwMkCwNlkh\|ryP	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
LoVo	NEniO3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MYXJR\|UxRTBwMkCyNFIh\|ryP	MlLuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
HAL-01	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFrsZ4hKSzVyPUCuNlAzQTdizszN	MlSzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
HCC2218	NHK0fJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NEXYcpFKSzVyPUCuNlA3QDhizszN	NHHWbYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
BEN	NETFSXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NHLIPXdKSzVyPUCuNlEzQTNizszN	M3nWT\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
LC-2-ad	MnzGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3zWbmlEPTB;MD6yNlA5PCEQvF2=	NWPsXYdWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
LXF-289	NH\mTmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NYKxVpNTUUN3ME2wMlI2ODRzIN88US=>	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
HGC-27	NXW5bXZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NYjtRldHUUN3ME2wMlI3PDF2IN88US=>	MlvFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
LK-2	NWnHUW9PT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MlKxTWM2OD1yLkK2PFI1KM7:TR?=	MlryQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
CTB-1	M{PsZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MnjCTWM2OD1yLkK3NlE2KM7:TR?=	M2nwU\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
697	NVT2TWtiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NH\4dIVKSzVyPUCuNlc{PjdizszN	NHm1SoY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
ES7	NV\vPHllT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1PVT2lEPTB;MD6yO\|M5OyEQvF2=	Ml75QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
MG-63	M2nBR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MoTjTWM2OD1yLkK3OFA4KM7:TR?=	NIPvbXQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
T47D	Mn;NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mnm4TWM2OD1yLkK3OFc2KM7:TR?=	NE[1[Go9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
RPMI-8226	NYLNXVU3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXjJR\|UxRTBwMki1PFkh\|ryP	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
NCI-H292	M4rmN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1rYZmlEPTB;MD6yPVE3PCEQvF2=	MlewQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
HT	NUXscFNjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Moj6TWM2OD1yLkK5N\|gh\|ryP	NETMU\|A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
A3-KAW	MmjsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M4W4R2lEPTB;MD6yPVc1KM7:TR?=	NV;JcnAxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
LB2241-RCC	NFi0Z3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVvJR\|UxRTBwM{CxPVgh\|ryP	M4HJUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
BB65-RCC	NVLzfFBST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M4rybmlEPTB;MD6zNFgxPSEQvF2=	M3LhOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
G-401	MkfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NXPBNHBmUUN3ME2wMlMxQTh4IN88US=>	NEC5WYc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
TYK-nu	M2TxeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NUjJR4ZjUUN3ME2wMlMyQDZ2IN88US=>	M3\MWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
NCI-SNU-1	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NIfsfVVKSzVyPUCuN\|I{OzFizszN	NVTDRZk2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
CHL-1	NYP3bW9ZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUe3eHl2UUN3ME2wMlMzPzB\|IN88US=>	MorxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
P30-OHK	NYjleGFKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1iy[2lEPTB;MD6zNlcxPSEQvF2=	M3H1flxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
PA-1	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NED6XGxKSzVyPUCuN\|M3OTlizszN	NUDjZ5lZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
LB1047-RCC	NIize5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVTJR\|UxRTBwM{SwOFch\|ryP	M2Hzd\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
EM-2	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MX\JR\|UxRTBwM{SxPFgh\|ryP	M2KwblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
VA-ES-BJ	M1\JOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MoCzTWM2OD1yLkO0NlY5KM7:TR?=	NWDvbYUzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
NCI-H520	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlLxTWM2OD1yLkO0PFM1KM7:TR?=	M{nCelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
ECC10	NF[0b\|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MUTJR\|UxRTBwM{WwN\|Uh\|ryP	NV:zOXJ3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
LNCaP-Clone-FGC	MlzVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHryWlJKSzVyPUCuN\|U{OTRizszN	M1jheVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
ES8	NHP2T\|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MoX2TWM2OD1yLkO2OVU{KM7:TR?=	M{jwZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
HuO-3N1	M3[wWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MnnVTWM2OD1yLkO4N\|c6KM7:TR?=	MkjFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
L-363	M{P4dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NGT0b5FKSzVyPUCuN\|kxOjZizszN	MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
SK-LU-1	NXfiU3kxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MmLWTWM2OD1yLkO5NlA5KM7:TR?=	NUW3SIlXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
MCF7	NWHmOpdTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NFHCcm5KSzVyPUCuOFA2OyEQvF2=	M4LmOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
HuO9	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MWPJR\|UxRTBwNEC2Olch\|ryP	NVnxdpNjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
BHT-101	NYTMSnRrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXf2elgxUUN3ME2wMlQxPzh5IN88US=>	NWHtRYpjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
MZ2-MEL	MmrvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGnKeG1KSzVyPUCuOFA5QDJizszN	MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
NOS-1	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MV\JR\|UxRTBwNEGwO\|Qh\|ryP	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
NEC8	MkLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlrOTWM2OD1yLkSxOlk2KM7:TR?=	NXTNWYtORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
COR-L88	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NVfDbJNuUUN3ME2wMlQzOjZ5IN88US=>	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
MFM-223	MnHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYnJR\|UxRTBwNEK2NVch\|ryP	M1fZelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
HSC-3	M1zsWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mn7sTWM2OD1yLkSyPVA5KM7:TR?=	MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
OVCAR-5	NIHMN3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MUjJR\|UxRTBwNEK5N\|Mh\|ryP	NYmwO5Q1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
MFE-280	NWjMbHViT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2\kdGlEPTB;MD60N\|A{OiEQvF2=	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
KP-N-YS	MlT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1L4NGlEPTB;MD60N\|A4KM7:TR?=	M4rV[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
EPLC-272H	NXfWUnNST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHjaU\|BKSzVyPUCuOFMxPzdizszN	NF3OW5k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
KE-37	NELnV3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NEXRWXhKSzVyPUCuOFMzPDdizszN	MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
HuH-7	NHzDRotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVjJR\|UxRTBwNEOzO\|Ih\|ryP	NVvmdYoyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
CHP-212	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2HCcmlEPTB;MD60N\|Y6PyEQvF2=	M{jDWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
SK-MES-1	NI[zOFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NYe1OZpRUUN3ME2wMlQ{QDR6IN88US=>	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
SJSA-1	NWr6cWhvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUDiRZN1UUN3ME2wMlQ1PTV2IN88US=>	MmnDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
QIMR-WIL	M{m5[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MUDJR\|UxRTBwNEWxOUDPxE1?	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFAyOjB2Lze+V2FPT0WUPD;hQi=>
ES4	NISwW3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXnzZm1yUUN3ME2wMlQ2OzN4IN88US=>	NHnNXXE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
TI-73	MmLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFrob4lKSzVyPUCuOFU3QDZizszN	MmXzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
COLO-684	M4i1cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NH;CWGhKSzVyPUCuOFU4OjZizszN	NFfI[oY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
GCIY	MmrOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MWHJR\|UxRTBwNEW3OVQh\|ryP	M4fnN\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5ODF{MESvK\|5USU6JRWK8M4E,
JVM-3	MlrMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NIjNWHJKSzVyPUCuOFYzQTJizszN	NIL6T5g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDBzMkC0M{c,W0GQR1XSQE9iRg>?
MPP-89	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MWXJR\|UxRTBwNE[5OFch\|ryP	MlvyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
M14	NF\qRndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M37WeWlEPTB;MD60O\|E4KM7:TR?=	MnzjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
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RT-112	MlrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MoD3TWM2OD1yLki0PVM4KM7:TR?=	NYTKVG52RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
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RPMI-8866	NWfMXoJST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M4jyS2lEPTB;MD64OVgzOiEQvF2=	MnHoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVgxOTJyND:nQnNCVkeHUkyvZV4>
CAL-120	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlTCTWM2OD1yLki2NFQyKM7:TR?=	NVPj[pZnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOThyMUKwOE8oRlODTlfFVlww[T5?
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L3.6pl	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NG\YcJAyKM7:TR?=	M4nlcVczKGh?		MWDpcohq[mm2czD0bIUh[2WubDDndo94fGhiY3;tZolv\WRid3n0bEBDVVNvN{e3OlA4	Mlz5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{M{OzPVkoRjJ2MkOzN\|k6RC:jPh?=
TE671	M4PRUGFxd3C2b4Ppd{BCe3OjeR?=	M2nlb\|Eh\|ryP	NFK3WlA1QCCq		NYqzZ4NucW6lcnXhd4V{KGOnbHygZZBweHSxc3nzJIlv\HWlZXSgZpkhSUKWLUezOy=>	M2m5PFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUOzNlE5Lz5{NEGzN\|IyQDxxYU6=
RD	NVqx[3gzSXCxcITvd4l{KEG\|c3H5	M1HIeVEh\|ryP	NFPXbJo1QCCq		M{LsNIlv[3KnYYPld{Bk\WyuIHHwc5B1d3OrczDpcoR2[2WmIHL5JGFDXC15M{e=	NH3DVo89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEGzN\|IyQCd-MkSxN\|MzOTh:L3G+
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Hep-2	MkHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2nTVlAvODFvMTFOwG0>	M2PZOlEzNTl4IHi=		MWPpcoNz\WG\|ZYOgZ4VtdCCmZXH0bEBqdiCjIHPvcoNmdnS{YYTpc44uKGGwZDD0bY1mNWSncHXu[IVvfCCvYX7u[ZI>	MmnhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzMEO3OFkoRjJ2MUCzO\|Q6RC:jPh?=
SCC-9	MnPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXHvWohOOC5yMT2xJO69VQ>?	MW[xNk06PiCq		M1GwWIlv[3KnYYPld{Bk\WyuIHTlZZRpKGmwIHGgZ49v[2WwdILheIlwdi1iYX7kJJRqdWVvZHXw[Y5l\W62IH3hco5meg>?	M{Xtd\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUCzO\|Q6Lz5{NEGwN\|c1QTxxYU6=
Hep-2	NXSwVpl1TnWwY4Tpc44hSXO\|YYm=	M2PRclAvOS9yLkWg{txO	M{KwWVI1KGh?		M{LNW4Jtd2OtczDtWG9TSzFiYX7kJI1VV1KFMjDhZ5RqfmG2aX;u	Mm[5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzMEO3OFkoRjJ2MUCzO\|Q6RC:jPh?=
SCC-9	M4rUOGZ2dmO2aX;uJGF{e2G7	M2jPVVAvOS9yLkWg{txO	MXGyOEBp		NVrocZVX[myxY3vzJI1VV1KFMTDhcoQhdVSRUlOyJIFkfGm4YYTpc44>	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDFyM{e0PUc,OjRzMEO3OFk9N2F-
PANC-1	MUPBdI9xfG:\|aYOgRZN{[Xl?	M4GzT\|UxOCCwTR?=	M2XmSVQ5KGh?		NF;vPYx{\W6\|aYTpfoV{KHCjbnPy[YF1cWNiY3HuZ4VzKGOnbHzzJJRwKHKjZHnveIhmemGyeR?=	MnTCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6OE[yPVQoRjJ\|OEi2Nlk1RC:jPh?=
RMG2	NIn5SZJCeG:ydH;zbZMhSXO\|YYm=	MWmxMVExODBibl2=	M1m1ZVczKGh?	NV7Ub5dSTkKV	MXTpcohq[mm2czD0bIUh[2WubDD2bYFjcWyrdImgZ49v[2WwdILheIlwdiCmZYDlcoRmdnSueR?=	NIriTIU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[xOVY{OSd-MkO2NVU3OzF:L3G+
HAC2	MYnBdI9xfG:\|aYOgRZN{[Xl?	Mnm3NU0yODByIH7N	M{L0[VczKGh?	MVXGRnM>	NE\nRYZqdmirYnn0d{B1cGViY3XscEB3cWGkaXzpeJkh[2:wY3XueJJifGmxbjDk[ZBmdmSnboTsfS=>	NIjFfYQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[xOVY{OSd-MkO2NVU3OzF:L3G+
HT-29	MUTBdI9xfG:\|aYOgRZN{[Xl?	M4rmT\|Eh\|ryP	MXS3NkBp		MUjheJRmdnWjdHXzJFUuTlVvaX7keYNm\CClZXzsJIRm[XSq	MlG0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NEmxNlEoRjJzOUS5NVIyRC:jPh?=
DLD1	NUHr[WlzSXCxcITvd4l{KEG\|c3H5	MnPFNUDPxE1?	MYe3NkBp		NUXjUZlL[XS2ZX71ZZRmeyB3LV\VMYlv\HWlZXSgZ4VtdCCmZXH0bC=>	NUPYUIlPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OFkyOjFpPkKxPVQ6OTJzPD;hQi=>
HT-29	M{i1OmZ2dmO2aX;uJGF{e2G7	NFfOWGUyKM7:TR?=	NG[4R4w4OiCq		MWLpcoR2[2W\|IHH1eI9xcGGpeTD0c{Bkd26oZYKgZ5l1d3C{b4TlZ5Rqd25?	NEL0NZU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm0PVEzOSd-MkG5OFkyOjF:L3G+
DLD1	MYnGeY5kfGmxbjDBd5NigQ>?	NUj3OHJ7OSEQvF2=	M{fjUlczKGh?		MUnpcoR2[2W\|IHH1eI9xcGGpeTD0c{Bkd26oZYKgZ5l1d3C{b4TlZ5Rqd25?	NUKwZ\|lKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OFkyOjFpPkKxPVQ6OTJzPD;hQi=>
Rh41	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmDPTWM2OD1\|MD63JI5O	M4rKUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzM{O3Olc6Lz5{MUOzO\|Y4QTxxYU6=
Rh18	NGrLXo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MmCyTWM2OD12MT60JI5O	NYPkbFI6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzN\|c3PzlpPkKxN\|M4Pjd7PD;hQi=>
Rh30	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M1jvOmlEPTB;MUSgcm0>	MnnBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF\|M{e2O\|koRjJzM{O3Olc6RC:jPh?=
BT-12	MmT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NV\PTo5TUUN3ME2yOE44KG6P	NVL6b4Z2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzN\|c3PzlpPkKxN\|M4Pjd7PD;hQi=>
CHLA-266	M4PVSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2DkfGlEPTB;MT6xJI5O	NHG1dpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUOzO\|Y4QSd-MkGzN\|c3Pzl:L3G+
TC-71	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MX;JR\|UxRTR4LkWgcm0>	NXT0NHdtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzN\|c3PzlpPkKxN\|M4Pjd7PD;hQi=>
CHLA-9	Ml7JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MmfSTWM2OD1zNT6zJI5O	M1nqNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzM{O3Olc6Lz5{MUOzO\|Y4QTxxYU6=
CHLA-10	MmfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NIjmNppKSzVyPUOuPUBvVQ>?	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTN\|N{[3PUc,OjF\|M{e2O\|k9N2F-
CHLA-258	MoCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1rafWlEPTB;MUCuOEBvVQ>?	M3nQVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzM{O3Olc6Lz5{MUOzO\|Y4QTxxYU6=
GBM2	NHrMWmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MYHJR\|UxRTRyLkegcm0>	NHzF[5M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUOzO\|Y4QSd-MkGzN\|c3Pzl:L3G+
NB-1643	NXnae2s3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{XYbWlEPTB;M{OuPEBvVQ>?	MnfyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF\|M{e2O\|koRjJzM{O3Olc6RC:jPh?=
NB-EBc1	MnfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3PHbWlEPTB;MkeuNUBvVQ>?	NVfOVWtURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzN\|c3PzlpPkKxN\|M4Pjd7PD;hQi=>
CHLA-90	NVHzUWhuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MVPJR\|UxRTN2LkWgcm0>	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTN\|N{[3PUc,OjF\|M{e2O\|k9N2F-
CHLA-136	NVHTfGFQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mn;MTWM2OD1zNkKuOkBvVQ>?	NX;2SmVLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzN\|c3PzlpPkKxN\|M4Pjd7PD;hQi=>
NALM-6	MmDxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mmj1TWM2OD1\|Mj65JI5O	M1LvOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzM{O3Olc6Lz5{MUOzO\|Y4QTxxYU6=
COG-LL-317	M1;kdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NYTFNXo5UUN3ME2xMlMhdk1?	NID4WHg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUOzO\|Y4QSd-MkGzN\|c3Pzl:L3G+
RS4;11	NHfLWZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NIraemtKSzVyPUO1JI5O	M4PkSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzM{O3Olc6Lz5{MUOzO\|Y4QTxxYU6=
MOLT-4	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4W2[2lEPTB;OD62JI5O	MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTN\|N{[3PUc,OjF\|M{e2O\|k9N2F-
CCRF-CEM	MkT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2i2SWlEPTB;ND6xJI5O	NIPL[3o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUOzO\|Y4QSd-MkGzN\|c3Pzl:L3G+
Kasumi-1	Ml7vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVjiWXdmUUN3ME2xMlQhdk1?	M{G2UlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzM{O3Olc6Lz5{MUOzO\|Y4QTxxYU6=
Karpas-299	M1zuNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYLJR\|UxRTJzLkegcm0>	M4q3NFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzM{O3Olc6Lz5{MUOzO\|Y4QTxxYU6=
Ramos-RA1	NHi3XpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MX3JR\|UxRThwMjDuUS=>	NFK3NFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUOzO\|Y4QSd-MkGzN\|c3Pzl:L3G+
H838	MnrSSpVv[3Srb36gRZN{[Xl?	NX\2OIZEOSEQvF2=	MkOwOFghcA>?		M4q4XIlv\HWlZYOgZ4VtdCCjdYTvdIhi\3l?	NV7acnpSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzOlQyOTNpPkKwN\|Y1OTF\|PD;hQi=>
H838	MoHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXuwMVMh\|ryP	NWjwO3JDPzJiaB?=		NV3mbmVqcW6mdXPld{Boem:5dHigbY5pcWKrdHnvckBidmRiYYX0c5Bp[We7	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODB{OEi1OEc,OjByMki4OVQ9N2F-
A549	NV7nVmU6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYewMVMh\|ryP	NHnvOFM4OiCq		MnjDbY5lfWOnczDndo94fGhiaX7obYJqfGmxbjDhcoQh[XW2b4DoZYd6	MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODB{OEi1OEc,OjByMki4OVQ9N2F-

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-mTOR / p-AKT / p-4EBP1 / p-P70S6K / p-PRAS40; PubMed: 24457069 Breast Cancer Res Western blots of 70% confluent TamR (A) and MCF7-X (B) cells treated for 15 minutes to 24 hours with AZD8055 (0 to 100 nM). Blots were probed with phospho- and total antibodies for mTORC1 and two signalling pathways. In both cell lines mTORC1 and mTORC2 s䲧疝Ỵ疞㧀疜膉痘 瘿삨ՂᾰƌՂĀ 㺣痖帉痖Ѐ瑖堘𢡄빢᎒ՂĀ鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙 p-EGFR / EGFR; PubMed: 25654224 Int J Mol Sci PANC-1 cells were treated with AZD8055 for the indicated hours and EGFR (T/P), AKT (T/P) and ribosomal protein S6 (S6) (T/P) proteins were examined by western-blot; p-FOXO1 / FOXO1 / p-FOXO3a / FOXO3a ; PubMed: 25654224 Int J Mol Sci PANC-1 cells were transfected with FoxO1/FoxO3a siRNAs and treated with AZD8055 for 1 h, then AKT (T/P), FoxO1 (T/P), FoxO3a (T/P) and EGFR (T/P) proteins were examined by western-blot.	24457069 25654224
Immunofluorescence	p-4EBP1 / EIF4E / mTOR; PubMed: 24600487 Int J Clin Exp Med (C) Hoechst 33258 staining of Hep-2 cells after treatment with AZD8055 for 24 hours were shown. The cells were fixed and immunereacted with anti-mTOR antibody followed by incubation with Alexa 488-labeled secondary antibody (C-F). Images were taken by a c䲧疝Ỵ疞㧀疜膉痘 瘿삨ՂᾰƌՂĀ 㺣痖帉痖Ѐ瑖堘𢡄빢᎒ՂĀ鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ�෋䐺痖暼瘿�෋ᾰƌ �෋à㺣痖�෋𢡄�෋䀷痗�෋౴�෋㵶痗�෋뺖᎒泌Itemｾ᎒Count﫨呂�෋猴፲�෋፲씢痗猸፲髸莤䥷堙᎒ｾ᎒�堞ﻮ᎒፲露𢡄堚،齃礤v�堞ﻮ᎒猢Wｾ᎒䨼Ą鹿齃殺獸W戀醙玛W戀ⶰ໯齃礤v 玚W玢Wⶰ໯﫰礌vtЉᔈැ鲬౴᥊疜犈፲Eo狜፲艘ᎂ艘ᎂ⩈̎䥠̌씢痗狠፲붖᎒i變ﱘ﫰﬐먙堘붖᎒狠፲i變ﱘ﫰먰堘ﱘ붖᎒�堞봆᎒릎堘붖᎒i꣩쯟巰痗ꣵ쯟巰痗Љ镴౴嶴痗Љ镨౴ᔈැ竗ᔈැ屷痗W竗尊痗 LC3B / p62 ; PubMed: 30337536 Cell Death Dis Immunofluorescence staining of U87 and U251 GICs, which treated by DMSO, AZD8055 (0.3 μM) and rapamycin (3 μM). The nuclei were stained with DAPI and the antibody against LC3B and p62. Images were captured by laser confocal microscope ( × 400), scale bar 䲧疝Ỵ疞	24600487 30337536
Growth inhibition assay	Cell viability ; PubMed: 29263324 Nat Commun Growth for the indicated cell lines was assessed after 72 h of treatment with AZD8055 (0–250 nM). Results are expressed as a percentage of cell number relative to the DMSO-treated control cells a.	29263324

体内研究

AZD8055 按2.5/10 mg/kg剂量作用于U87MG和A549移植瘤抑制pS6和pAKT，导致肿瘤生长受抑制。AZD8055按10/20 mg/kg剂量处理多种移植瘤包括U87MG, BT474c, A549, Calu-3, LoVo, SW620, PC3和MES-SA时，显示出明显的抗癌活性。^[1] AZD8055诱导肿瘤体积下降约40%, 伴随着AKT, S6K，和SGK蛋白激酶磷酸化的切除。用AZD8055 (5mg/kg, 每天2次) 和SAHA (100 mg/kg/每天)处理PTEN+/−LKB1+/hypo 移植瘤，导致肿瘤生长全部受抑制，且对鼠mTORC1和mTORC2信号抑制没有副作用。^[4]

激酶实验：^[1]	- 合并抑制mTOR的细胞为基础的测定实验: 通过高通量筛选细胞检测法，使用MDA-MB-468细胞，测定mTORC1 和mTORC2活性。用增加浓度的AZD8055处理细胞2小时。温育到最后时，细胞进行固定，冲洗，用p-Akt（S473）抗体和p-S6（S235/236)抗体探测。用激光扫描仪检测磷酸化水平。
细胞实验：^[1]	- 合并 Cell lines: U87MG, A549，和H838 细胞 Concentrations: 溶解在DMSO中，作为10 mM 储备液, 0.001-1.0 μM Incubation Time: 72到96小时 Method: 用AZD8055处理细胞72到96小时，用0.03 mg/mL Hoechst 33342染色细胞核，用1 μg/mL 吖啶橙染色酸性小囊泡染色。通过ArrayScan II平台在450和536纳米处获得图像，测量酸性小囊泡的百分数和细胞数量。进行LC3测评，用10 μg/mL e64d/抑肽素处理细胞30 到90分钟，然后和AZD8055温育。细胞溶解在冰上，通过免疫印迹法分析。 (Only for Reference)
动物实验：^[1]	- 合并 Animal Models: U87MG, BT474c, A549, Calu-3, LoVo, SW620, PC3 and MES-SA U87-MG和A549细胞建立在无病原体，雌性裸鼠体内(nu/nu:Alpk)。 Dosages: 2.5-20 mg/kg Administration: 口服饲喂，每天1到2次。 (Only for Reference)

参考文献

[4] García-Martínez JM, et al. Br J Cancer, 2011, 104(7), 1116-1

- 合并

溶解度 (25°C)

体外	DMSO	50 mg/mL warmed (107.4 mM)
	Ethanol	3 mg/mL (6.44 mM)
	Water	Insoluble
体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： 4% DMSO+30% PEG 300+ddH2O	5mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download AZD8055 SDF

分子量	465.54
化学式	C₂₅H₃₁N₅O₄
CAS号	1009298-09-2
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	N/A

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

临床试验信息 (data from https://clinicaltrials.gov, updated on 2021-05-17)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT01316809	Completed	Drug: AZD8055	Glioblastoma Multiforme\|Anaplastic Astrocytoma\|Anaplastic Oligodendroglioma\|Malignant Glioma\|Brainstem Glioma	National Cancer Institute (NCI)\|National Institutes of Health Clinical Center (CC)	March 4 2011	Phase 1
NCT00999882	Completed	Drug: AZD8055	Cancer\|Advanced Hepatocellular Carcinoma	AstraZeneca	October 2009	Phase 1
NCT00973076	Completed	Drug: AZD8055	Cancer\|Solid Tumors\|Advanced Solid Malignancies	AstraZeneca	August 2009	Phase 1
NCT00731263	Completed	Drug: AZD8055	Solid Tumors	AstraZeneca	July 2008	Phase 1
NCT01194193	Withdrawn	Drug: AZD8055	Cancer\|Advanced Solid Tumours\|Lymphomas	AstraZeneca		Phase 1

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

mTOR Signaling Pathway Map

mTOR Inhibitors with Unique Features

选择性强的mTOR抑制剂

Rapamycin (Sirolimus) : mTORC1-selective, IC50=~0.1 nM.
活性最高的mTOR抑制剂

Rapamycin (Sirolimus) : mTOR, IC50=~0.1 nM.
FDA批准的mTOR抑制剂

Temsirolimus (CCI-779, NSC 683864) : Approved by FDA for Renal Cell Carcinoma (RCC).
最新的mTOR抑制剂

XL388 ^New : Highly potent, selective, ATP-competitive inhibitor of mTOR with IC50 of 9.9 nM, 1000-fold selectivity over the closely related PI3K kinases.

研究领域

产品类型

定制您的化合物库

AZD8055

客户使用Selleck生产的AZD8055发表文献207篇：

产品安全说明书

mTOR抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download AZD8055 SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

临床试验信息 (data from https://clinicaltrials.gov, updated on 2021-05-17)

技术支持

mTOR Signaling Pathway Map

mTOR Inhibitors with Unique Features

相关mTOR产品