AZD8055

For research use only. Not for use in humans.

目录号:S1555

AZD8055 Chemical Structure

CAS No. 1009298-09-2

AZD8055是一种新型的,ATP竞争性mTOR抑制剂,在MDA-MB-468 细胞中IC50为0.8 nM,与作用于PI3K亚型和ATM/DNA-PK相比,具有优异的选择性(约1000倍)。AZD8055可诱导半胱天冬酶依赖的凋亡和自噬。Phase 1。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1265.49 现货
RMB 712.53 现货
RMB 988.31 现货
RMB 3048.72 现货
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客户使用Selleck生产的AZD8055发表文献153篇:

产品安全说明书

mTOR抑制剂选择性比较

生物活性

产品描述 AZD8055是一种新型的,ATP竞争性mTOR抑制剂,在MDA-MB-468 细胞中IC50为0.8 nM,与作用于PI3K亚型和ATM/DNA-PK相比,具有优异的选择性(约1000倍)。AZD8055可诱导半胱天冬酶依赖的凋亡和自噬。Phase 1。
特性 AZD8055是第一种抑制两种类型mTOR蛋白的药物,被认为可能比之前mTOR抑制剂更有效。
靶点
mTOR (truncated) [1]
(MDA-MB-468 cells)
mTOR (full length) [1]
(MDA-MB-468 cells)
0.13 nM 0.8 nM
体外研究

AZD8055作用于所有 PI3K亚型 (α, β, γ, δ) 和其他近PI3K激酶家族(ATM和DNA-PK)显示出低活性。AZD8055抑制mTORC1(p70S6K 和4E-BP1) ,mTORC2 (AKT) 和下游蛋白的磷酸化。AZD8055完全抑制4E-BP1抗Rapamycin 的T37/46 磷酸化位点, 导致明显抑制cap-dependent 转译作用。AZD8055有效抑制U87MG, A549和H838 细胞增殖, IC50分别为53, 50,和20 nM。AZD8055作用于H838和A549细胞,也诱导自体吞噬和增加LC3-II 水平。[1] AZD8055降低白血病细胞增殖和细胞周期进展, 降低白血病祖细胞的无性系生长,且在白血病细胞中诱导caspase依赖的细胞凋亡,但是作用于正常未成熟的CD34+ 细胞时不会产生这种诱导作用。[2] AZD8055 抑制儿科临床前期测试计划(PPTP)细胞系,IC50 为24.7 nM,且在EFS 分布时诱导产生明显区别。[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
LU-139 NITjcZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XCRmlEPTB;MD6wNlM{OSEQvF2= NH3FO|FUSU6JRWK=
NCI-H720 M1LzdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILIclBKSzVyPUCuNFI6OzhizszN NU\jXFBnW0GQR1XS
KARPAS-45 Mn\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{X5R2lEPTB;MD6wN|M4OSEQvF2= M2\XXXNCVkeHUh?=
EW-3 NE\LVVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwMESwOVYh|ryP NYjITFF7W0GQR1XS
SBC-1 NWW0RnpbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TONGlEPTB;MD6wOFU5OSEQvF2= NXvMPVFRW0GQR1XS
NCI-H209 M1fVZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWP5OJhlUUN3ME2wMlA2PDV|IN88US=> NI\aVpVUSU6JRWK=
EoL-1-cell NUPmU2RTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX30e3VFUUN3ME2wMlA3PTZ7IN88US=> NUSwTWtRW0GQR1XS
H9 NXjhO2l{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLVTWM2OD1yLkC2OlkzKM7:TR?= M33UVHNCVkeHUh?=
AN3-CA NVTaNVFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLNSm5NUUN3ME2wMlA4QTVzIN88US=> MmfDV2FPT0WU
HH NGexeJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfvTWM2OD1yLkC4NFA6KM7:TR?= NH7TdJRUSU6JRWK=
KU812 MnTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPHSZRNUUN3ME2wMlA5ODR|IN88US=> MXPTRW5ITVJ?
DU-4475 NF3meo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwMEiwOFch|ryP NXi5bWF2W0GQR1XS
CTV-1 NHuyXVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHe5RZhKSzVyPUCuNFg3PDFizszN M{XrRnNCVkeHUh?=
BV-173 M2n4XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYH4WXViUUN3ME2wMlA6ODZzIN88US=> M1\CPHNCVkeHUh?=
ES5 M2D2PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwMEmzOUDPxE1? MXnTRW5ITVJ?
G-402 MlzHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\jTWM2OD1yLkC5PVgh|ryP MVrTRW5ITVJ?
MV-4-11 Mmi5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHpTWM2OD1yLkGwN|Q4KM7:TR?= MmjEV2FPT0WU
NB69 M1foe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwMUO1JO69VQ>? NILJRmZUSU6JRWK=
EGI-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjkdlNZUUN3ME2wMlE{PTNzIN88US=> NX3aWG1DW0GQR1XS
EW-18 M4H1Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzU[o9GUUN3ME2wMlE1ODd|IN88US=> Mn\pV2FPT0WU
ME-180 MoW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzXenVKSzVyPUCuNVQ3QDFizszN MkXNV2FPT0WU
D-283MED MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLIXIlFUUN3ME2wMlE1PzJ|IN88US=> MUTTRW5ITVJ?
NB14 NVruOmdKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3IOldKSzVyPUCuNVY1PDdizszN NF;RcIhUSU6JRWK=
Ramos-2G6-4C10 NVnkNVdHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHq3Uo9KSzVyPUCuNVY6QDNizszN NGrmdIVUSU6JRWK=
NBsusSR MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDETYNKSzVyPUCuNVcxOTlizszN M2DJRnNCVkeHUh?=
LAMA-84 MljJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPPTWM2OD1yLkG4NFMzKM7:TR?= MnS0V2FPT0WU
NCI-H1581 NU\HblVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzqfVlKSzVyPUCuNVg6PjZizszN NXzKc|BqW0GQR1XS
A204 NY\ETItxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXn2OZZGUUN3ME2wMlE5QTdizszN MnTjV2FPT0WU
A549 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljBTWM2OD1yLkG5OVUh|ryP M3foWXNCVkeHUh?=
CAL-51 MmHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVn2XnhDUUN3ME2wMlE6PjVzIN88US=> M1XjWHNCVkeHUh?=
NKM-1 MnfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTBwMkCwNlkh|ryP M3fkcXNCVkeHUh?=
LoVo MmDwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLSTHVUUUN3ME2wMlIxOjB{IN88US=> M2m1fnNCVkeHUh?=
HAL-01 NYDqdmlYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TrWGlEPTB;MD6yNFI6PyEQvF2= NXTDZphWW0GQR1XS
HCC2218 MnvFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\hZog{UUN3ME2wMlIxPjh6IN88US=> MXfTRW5ITVJ?
BEN M1jrPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTBwMkGyPVMh|ryP M4XwOnNCVkeHUh?=
LC-2-ad MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTBwMkKwPFQh|ryP MmPaV2FPT0WU
LXF-289 NWnXPG5zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jRS2lEPTB;MD6yOVA1OSEQvF2= M3;2S3NCVkeHUh?=
HGC-27 NEnLdVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;hTWM2OD1yLkK2OFE1KM7:TR?= Mm\UV2FPT0WU
LK-2 M4Hm[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TZWWlEPTB;MD6yOlgzPCEQvF2= M2LHcHNCVkeHUh?=
CTB-1 MkPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTBwMkeyNVUh|ryP NFPpdZlUSU6JRWK=
697 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fFXGlEPTB;MD6yO|M3PyEQvF2= MoPMV2FPT0WU
ES7 M3y3Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwMkezPFMh|ryP M3TIZ3NCVkeHUh?=
MG-63 MnHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTBwMke0NFch|ryP NXn6ZWtJW0GQR1XS
T47D M1yzfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG[z[mxKSzVyPUCuNlc1PzVizszN MUjTRW5ITVJ?
RPMI-8226 NGPzb|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nsXWlEPTB;MD6yPFU5QSEQvF2= NYXEVGkyW0GQR1XS
NCI-H292 NXXDVoNVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLSTWM2OD1yLkK5NVY1KM7:TR?= MV3TRW5ITVJ?
HT NXLBdJNjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPzenRKSzVyPUCuNlk{QCEQvF2= NHrIT3FUSU6JRWK=
A3-KAW MmDaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLkNpkxUUN3ME2wMlI6PzRizszN M1GzOHNCVkeHUh?=
LB2241-RCC MkfZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwM{CxPVgh|ryP M3XGSXNCVkeHUh?=
BB65-RCC NUXMdYNwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwM{C4NFUh|ryP M2fBUnNCVkeHUh?=
G-401 Mnn5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXH5SnFtUUN3ME2wMlMxQTh4IN88US=> NEDmb4FUSU6JRWK=
TYK-nu NV:2RnF1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfKVm5HUUN3ME2wMlMyQDZ2IN88US=> NFLQOIVUSU6JRWK=
NCI-SNU-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vZemlEPTB;MD6zNlM{OSEQvF2= NFTWSmNUSU6JRWK=
CHL-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPJfYxKSzVyPUCuN|I4ODNizszN MVLTRW5ITVJ?
P30-OHK MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkCyTWM2OD1yLkOyO|A2KM7:TR?= M3nkNHNCVkeHUh?=
PA-1 M2fPe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzaZlZKSzVyPUCuN|M3OTlizszN MkHYV2FPT0WU
LB1047-RCC M3TsRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTBwM{SwOFch|ryP M1;rSnNCVkeHUh?=
EM-2 NVjtW5NMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnUXHB6UUN3ME2wMlM1OTh6IN88US=> NXnIemJ3W0GQR1XS
VA-ES-BJ MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYm5dGNxUUN3ME2wMlM1OjZ6IN88US=> NETXXFZUSU6JRWK=
NCI-H520 NIHnPWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTBwM{S4N|Qh|ryP MoTyV2FPT0WU
ECC10 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwM{WwN|Uh|ryP Mlj6V2FPT0WU
LNCaP-Clone-FGC MkDGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfK[XFKSzVyPUCuN|U{OTRizszN M361dXNCVkeHUh?=
ES8 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XmNGlEPTB;MD6zOlU2OyEQvF2= MUjTRW5ITVJ?
HuO-3N1 NUC3UJJMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwM{izO|kh|ryP MnrwV2FPT0WU
L-363 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\zWJBKSzVyPUCuN|kxOjZizszN NGrOfopUSU6JRWK=
SK-LU-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTPOZFtUUN3ME2wMlM6OjB6IN88US=> M3jjbXNCVkeHUh?=
MCF7 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwNEC1N{DPxE1? NUDkSoVCW0GQR1XS
HuO9 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnm0TWM2OD1yLkSwOlY4KM7:TR?= NE\lRoFUSU6JRWK=
BHT-101 NH3nXmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTBwNEC3PFch|ryP NW\JUnNEW0GQR1XS
MZ2-MEL M2\MNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTNSphNUUN3ME2wMlQxQDh{IN88US=> M1TFRnNCVkeHUh?=
NOS-1 NHe2enVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4naS2lEPTB;MD60NVA4PCEQvF2= MnXRV2FPT0WU
NEC8 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYKxempPUUN3ME2wMlQyPjl3IN88US=> NWfvO2dsW0GQR1XS
COR-L88 NXHsVplST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTBwNEKyOlch|ryP NUOwXphmW0GQR1XS
MFM-223 MlT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwNEK2NVch|ryP NWrxW5ZjW0GQR1XS
HSC-3 NFPsUIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rhfWlEPTB;MD60NlkxQCEQvF2= M{nYVHNCVkeHUh?=
OVCAR-5 NE\IO3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofXTWM2OD1yLkSyPVM{KM7:TR?= NEX3S|VUSU6JRWK=
MFE-280 NHnkeHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPuTWM2OD1yLkSzNFMzKM7:TR?= M2\HPXNCVkeHUh?=
KP-N-YS MnXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrrTWM2OD1yLkSzNFch|ryP MlPqV2FPT0WU
EPLC-272H NVHoZYNqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFz2cJZKSzVyPUCuOFMxPzdizszN NEnYSoZUSU6JRWK=
KE-37 NFjFWpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rzfWlEPTB;MD60N|I1PyEQvF2= NFP4dZlUSU6JRWK=
HuH-7 NHK4VZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzPNo1KSzVyPUCuOFM{PzJizszN NFLxSJJUSU6JRWK=
CHP-212 NIDiUVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwNEO2PVch|ryP MnHFV2FPT0WU
SK-MES-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPBXWVFUUN3ME2wMlQ{QDR6IN88US=> NILPc4tUSU6JRWK=
SJSA-1 MlHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwNES1OVQh|ryP Mn;VV2FPT0WU
QIMR-WIL MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDmNodKSzVyPUCuOFUyPSEQvF2= NW\ZenYxW0GQR1XS
ES4 M1\pZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwNEWzN|Yh|ryP NV[5dZRYW0GQR1XS
TI-73 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTBwNEW2PFYh|ryP MWDTRW5ITVJ?
COLO-684 NFLrU5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnyT2hKSzVyPUCuOFU4OjZizszN M1zU[XNCVkeHUh?=
GCIY NWXrbmZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXOOmNKSzVyPUCuOFU4PTRizszN MVjTRW5ITVJ?
JVM-3 NVTJNIRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHQTWM2OD1yLkS2NlkzKM7:TR?= M3rlZXNCVkeHUh?=
MPP-89 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nsVWlEPTB;MD60Olk1PyEQvF2= MVnTRW5ITVJ?
M14 M{TKcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDFVFNuUUN3ME2wMlQ4OTdizszN MXfTRW5ITVJ?
SW962 NF[4S3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4X0c2lEPTB;MD60O|E6KM7:TR?= NFrnWY9USU6JRWK=
VM-CUB-1 M1v1SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3vOIdKSzVyPUCuOFczQDZizszN M2DV[nNCVkeHUh?=
A101D NWrQXo5UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3BTWM2OD1yLkS4PVY5KM7:TR?= NHrIOI9USU6JRWK=
DB MlvLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LnZmlEPTB;MD61NFAzOSEQvF2= MUHTRW5ITVJ?
KNS-62 NHywRoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fSNGlEPTB;MD61NFU3QCEQvF2= MUDTRW5ITVJ?
NCI-H460 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTjTWM2OD1yLkWwOVk4KM7:TR?= NFzkR4xUSU6JRWK=
MDA-MB-361 NYW5XWpyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nWSWlEPTB;MD61NFg4KM7:TR?= NGLmRoNUSU6JRWK=
DOK M1PtXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLqU3hKSzVyPUCuOVE{OzNizszN M{SyNXNCVkeHUh?=
CAL-39 NF6wS4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHoTWM2OD1yLkWyNlY5KM7:TR?= NFnpSmFUSU6JRWK=
HT-1080 M3\vfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkGzTWM2OD1yLkWyOVQ{KM7:TR?= MoDYV2FPT0WU
GR-ST Ml\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwNUOwNVUh|ryP MWjTRW5ITVJ?
J-RT3-T3-5 MkXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTOTWhGUUN3ME2wMlU{OTl3IN88US=> NV;Rd5p3W0GQR1XS
NCI-H1793 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn71TWM2OD1yLkWzOFQ4KM7:TR?= MV\TRW5ITVJ?
NCI-H1355 M2[yemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfRfWc1UUN3ME2wMlU{QDd6IN88US=> M2jNVXNCVkeHUh?=
YH-13 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3OVWhCUUN3ME2wMlU1QTN6IN88US=> NYryUHBvW0GQR1XS
LOXIMVI NVnHb2NNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jJWmlEPTB;MD61OVEzOyEQvF2= NEPHN4RUSU6JRWK=
ES1 MmewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4H4ZWlEPTB;MD61OVUyQCEQvF2= M3fNXXNCVkeHUh?=
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KNS-81-FD MoC4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTFwOEmxOlUh|ryP MU\TRW5ITVJ?
HN MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHCPZdKSzVyPUGuPFk2PDVizszN MVnTRW5ITVJ?
ACHN M2jtTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDjeIJ4UUN3ME2xMlkxPzh4IN88US=> NFPJ[pFUSU6JRWK=
HSC-2 M3;HTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfrbmNwUUN3ME2xMlkyODl4IN88US=> NFjCeJNUSU6JRWK=
HCC2998 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHV[XR4UUN3ME2xMlk{OzJ3IN88US=> Mn\wV2FPT0WU
HEL Ml3jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHvSnNRUUN3ME2xMlk1OTh2IN88US=> Mlq5V2FPT0WU
SW684 Mn;iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;2TWM2OD1zLkm3N|cyKM7:TR?= M{HLUHNCVkeHUh?=
NCI-H1693 MnTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HUSWlEPTB;MT65PFA5PiEQvF2= M1r5XnNCVkeHUh?=
8-MG-BA NFfidW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HWfGlEPTB;MT65PFIyKM7:TR?= NH71Z2RUSU6JRWK=
OVCAR-8 NVnZVJhFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\TemlEPTB;Mj6wNFI6PSEQvF2= NXrQTJJJW0GQR1XS
DSH1 NGLVXZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTJwMEG3O|Qh|ryP NVnEe2JCW0GQR1XS
KYSE-520 MkHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1[ze2lEPTB;Mj6wNlA1QSEQvF2= MlnaV2FPT0WU
GB-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1e5ZmlEPTB;Mj6wNlU4PyEQvF2= M2\JRnNCVkeHUh?=
RCC10RGB MnHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3uzcGlEPTB;Mj6wOFg4OSEQvF2= MoiyV2FPT0WU
SW954 M4PVVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvtTWM2OD1{LkC1NFM3KM7:TR?= NYDpe5pSW0GQR1XS
IST-MES1 MnnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XrWmlEPTB;Mj6wOVU3QCEQvF2= M3:wW3NCVkeHUh?=
AU565 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTJwMEW5NFUh|ryP MWrTRW5ITVJ?
CW-2 MlT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnqPItKSzVyPUKuNFY5PzVizszN NHSyeXlUSU6JRWK=
TE-1 MkfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;EcVZKSzVyPUKuNFk{PzdizszN MYTTRW5ITVJ?
KP-4 MkDZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn[1TWM2OD1{LkGwN|EzKM7:TR?= M1v0ZXNCVkeHUh?=
SNU-C2B NFzQTIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\aS2l2UUN3ME2yMlExQDJ|IN88US=> NYXMe4hLW0GQR1XS
NCI-H1395 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3vfWdKSzVyPUKuNVA6QDZizszN NGL3ZZFUSU6JRWK=
CAS-1 Ml3US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLkeXdMUUN3ME2yMlEyPTR4IN88US=> M3PWNHNCVkeHUh?=
NCI-H1155 M{nKfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTqVY1KSzVyPUKuNlI3QSEQvF2= M2DqU3NCVkeHUh?=
SK-MEL-1 MkXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTJwMkixPFEh|ryP M3\oNnNCVkeHUh?=
KINGS-1 NFT3NIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfqZXRLUUN3ME2yMlMxODh6IN88US=> NFvZRoVUSU6JRWK=
ESS-1 M3TWXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTJwM{C1NUDPxE1? NVfLe2RSW0GQR1XS
PANC-10-05 NV3sb4ZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\K[WlEPTB;Mj6zO|AzPCEQvF2= M{XQfHNCVkeHUh?=
HT-1376 MnnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHmzVnFKSzVyPUKuN|g4ODhizszN MU\TRW5ITVJ?
LS-513 NYTDVoVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPyTWM2OD1{LkO4PFc1KM7:TR?= M3v4SXNCVkeHUh?=
KNS-42 MlL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHWTWM2OD1{LkO5NVA2KM7:TR?= NYnqZ2FRW0GQR1XS
639-V MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXwfZNwUUN3ME2yMlQzPzV6IN88US=> MWPTRW5ITVJ?
SJRH30 M4L2Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{ezfWlEPTB;Mj60OVE3OSEQvF2= NXfzUYpJW0GQR1XS
SW1783 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\xRVVKSzVyPUKuOFcxPzhizszN NX32dmxlW0GQR1XS
NB6 M3\JNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fjW2lEPTB;Mj60PFI5KM7:TR?= NV\YOFdJW0GQR1XS
SK-MEL-30 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3y4SWlEPTB;Mj60PFg{KM7:TR?= NHf2T4FUSU6JRWK=
HCE-4 Mlq3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDmbVhKSzVyPUKuOFk1ODJizszN NVnIeIQxW0GQR1XS
NB10 NYPUO|g2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTJwNEm0Nlkh|ryP M2jTbXNCVkeHUh?=
H-EMC-SS MkPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7tbGdKSzVyPUKuOVQ3PSEQvF2= MXPTRW5ITVJ?
SK-HEP-1 M1jVSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\aTWM2OD1{LkW1NlM3KM7:TR?= NFTBbWpUSU6JRWK=
HCC1395 Mm\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoOwTWM2OD1{LkW1OlU2KM7:TR?= NFz2V|JUSU6JRWK=
HuCCT1 MlrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTJwNU[zPUDPxE1? NVvRUG9LW0GQR1XS
SiHa MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\JcmVvUUN3ME2yMlU5PzF7IN88US=> NXXCbZNTW0GQR1XS
EFO-21 NFP6fHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2m4ZmlEPTB;Mj61PFc3PCEQvF2= NWG0UFd3W0GQR1XS
NCI-H1666 M3HNRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPRdWlKSzVyPUKuOVkxPzZizszN MV;TRW5ITVJ?
UMC-11 NH24TpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPGXI1QUUN3ME2yMlU6QDZ6IN88US=> NFjPT2VUSU6JRWK=
COLO-679 NV73V4FST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PWeGlEPTB;Mj62NVI{OyEQvF2= M4nKNHNCVkeHUh?=
A388 NWf0SoZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrOVWlYUUN3ME2yMlY2OjV|IN88US=> MVrTRW5ITVJ?
LB2518-MEL NF3OcGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHv1Rm9KSzVyPUKuOlU1ODhizszN MV\TRW5ITVJ?
EW-13 NHvpe5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXCZnVJUUN3ME2yMlY5PzZ6IN88US=> MoTWV2FPT0WU
MLMA NFroWYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjCWVlJUUN3ME2yMlY5QDV4IN88US=> MXHTRW5ITVJ?
HOP-92 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTJwN{CxNUDPxE1? NHHlUlhUSU6JRWK=
NOMO-1 MkG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1W3T2lEPTB;Mj63NVQ1OiEQvF2= MWLTRW5ITVJ?
NCI-H810 M3jiZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTJwN{KxPVgh|ryP M37JeXNCVkeHUh?=
769-P MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGSyeI9KSzVyPUKuO|IzQCEQvF2= MX3TRW5ITVJ?
SAS M37aXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXqblRyUUN3ME2yMlc3PSEQvF2= MYfTRW5ITVJ?
M059J MoDVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fTW2lEPTB;Mj63PFMyQCEQvF2= M2OxNHNCVkeHUh?=
RD MmfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTyWo9KSzVyPUKuO|k1PzFizszN NEj3e3dUSU6JRWK=
GT3TKB Ml;2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTJwOEO0N|Mh|ryP MmXLV2FPT0WU
MZ7-mel MnnXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfIZ|BKSzVyPUKuPFY2ODJizszN NHXZUYxUSU6JRWK=
KYSE-510 M2DB[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7hbmlKSzVyPUKuPFk2ODRizszN M3vEWHNCVkeHUh?=
NCI-N87 MoX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjCflI{UUN3ME2yMlkyQDB5IN88US=> NWPtSYhnW0GQR1XS
MKN1 NUDRWFZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfJU5FKSzVyPUOuNFAyPjNizszN MoXiV2FPT0WU
NCI-H2170 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrG[|ZUUUN3ME2zMlAxPDVzIN88US=> NVHwVmhOW0GQR1XS
OVCAR-3 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1u5XGlEPTB;Mz6wNlEyPSEQvF2= M2f5eHNCVkeHUh?=
KLE NWrWeJE1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4D6bGlEPTB;Mz6wOlgyOiEQvF2= MUTTRW5ITVJ?
LB771-HNC NEfiSoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTNwMEmzOFMh|ryP NVewSWViW0GQR1XS
MC116 NWfUPGw3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXuTWM2OD1|LkGxNVEzKM7:TR?= NWPBZYJbW0GQR1XS
SCC-9 MmrmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWOwW5FTUUN3ME2zMlEyOzZ4IN88US=> M4qyeXNCVkeHUh?=
U031 NHPNXoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTNwMUK0NlMh|ryP NF3SUmFUSU6JRWK=
LCLC-103H M4rpeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\LNGFKSzVyPUOuNlM5QTRizszN MXTTRW5ITVJ?
U-266 NXG5ZXBGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXQTWM2OD1|LkK3OlM{KM7:TR?= Mn;sV2FPT0WU
JVM-2 MlPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWT1cFRRUUN3ME2zMlMzOTZ2IN88US=> M3;iOHNCVkeHUh?=
UACC-257 Mle2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrUOYxKSzVyPUOuOFY1OzFizszN NUSyXopuW0GQR1XS
LB996-RCC MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfpdVdKSzVyPUOuOFY2ODJizszN NXf6UIVCW0GQR1XS
BT-549 MkDrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYX4SWNGUUN3ME2zMlUxOjB7IN88US=> M1qxNnNCVkeHUh?=
NCI-H526 NYH6clBzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHITWM2OD1|LkW0NVU5KM7:TR?= NHXvWVVUSU6JRWK=
RH-18 NIHjWldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHz2ZodKSzVyPUOuOlE4QThizszN NYeyVWZOW0GQR1XS
SW626 NEXVSHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2ewbmlEPTB;Mz63NVEzQCEQvF2= M{PvcXNCVkeHUh?=
SK-N-AS NFK4d4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3P6RWlEPTB;Mz63N|I1PyEQvF2= M{G2ZnNCVkeHUh?=
IGR-1 NGLqO4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLTVY1uUUN3ME2zMlc1OjR6IN88US=> Ml7XV2FPT0WU
NCI-H2291 NF6x[HpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2i3cWlEPTB;Mz63OVM{PiEQvF2= MlzoV2FPT0WU
NCI-H441 NHjYd4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUn6S4hkUUN3ME2zMlgzPDN|IN88US=> NWfrSGgxW0GQR1XS
D-247MG MmrkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTOZ|lpUUN3ME2zMlg3ODNzIN88US=> NYXrXYhpW0GQR1XS
COLO-320-HSR NIDlbFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3yzUmlEPTB;Mz65NVI4OSEQvF2= NYDSUnl[W0GQR1XS
A253 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{Dzb2lEPTB;Mz65NVQ{PiEQvF2= NIW5[mdUSU6JRWK=
HT55 M1roSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTZNHVkUUN3ME2zMlkyPzd|IN88US=> NFfzUFFUSU6JRWK=
MZ1-PC NH\VfYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vtUmlEPTB;Mz65OVg3PCEQvF2= MnnoV2FPT0WU
RERF-LC-MS NYj5XpZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTNwOU[1NlUh|ryP M1LWTnNCVkeHUh?=
SF268 NV;MZmd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TicWlEPTB;ND6xNlg5OSEQvF2= NF31bYZUSU6JRWK=
RMG-I NGDJc5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\XTWM2OD12LkKxOFU1KM7:TR?= NX3OO|djW0GQR1XS
CFPAC-1 MmruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3i1bWlEPTB;ND6yNVY5PSEQvF2= MkDyV2FPT0WU
S-117 MnXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PJS2lEPTB;ND6yNlAzPCEQvF2= MVzTRW5ITVJ?
NCI-H2122 NUnQR2hzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XyUmlEPTB;ND6zNFk{OSEQvF2= MUDTRW5ITVJ?
J82 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PF[WlEPTB;ND6zN|Q1OSEQvF2= NIPTWmxUSU6JRWK=
CAL-72 M2fQeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTRwM{W0O|ch|ryP Mkn3V2FPT0WU
GP5d M1zLb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTRwNEGyPVgh|ryP MoC5V2FPT0WU
UACC-62 NHHmd41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DBXGlEPTB;ND60OlU1PSEQvF2= MnfjV2FPT0WU
MS-1 MofHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7xSIFKSzVyPUSuOFkyOTVizszN NWTCc|JSW0GQR1XS
RCM-1 Mn\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULJclRSUUN3ME20MlUzQTJizszN Ml7sV2FPT0WU
IST-SL1 NGHodGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vjNWlEPTB;ND62OVM2QSEQvF2= NVGzcZl2W0GQR1XS
SW756 NGm4N21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHITWM2OD12Lk[5NVM2KM7:TR?= M3LXW3NCVkeHUh?=
HCC38 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17aeGlEPTB;ND63NVE6PyEQvF2= MmDwV2FPT0WU
YAPC M2PuOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4P5NGlEPTB;ND63NVMyOyEQvF2= MY\TRW5ITVJ?
DK-MG MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH6xVIpKSzVyPUSuO|gyOTJizszN NHLaVnpUSU6JRWK=
HCC1937 M{\JOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTRwOEWxNlUh|ryP MVnTRW5ITVJ?
OAW-28 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTRwOUK0N|Uh|ryP M1PlcnNCVkeHUh?=
MEG-01 MoPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTVwMEizNlgh|ryP NH\1VnpUSU6JRWK=
GI-1 NWftS3RHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnGTWM2OD13LkKzOFg3KM7:TR?= MonVV2FPT0WU
FADU MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXwUm5KSzVyPUWuNlc5OzdizszN M4LyXHNCVkeHUh?=
CAPAN-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjTTWM2OD13LkO5OFMzKM7:TR?= NYXIXlFUW0GQR1XS
TGBC11TKB NWLYfIpHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTVwNEW3PFYh|ryP MVrTRW5ITVJ?
DBTRG-05MG M{DtcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvlWnkyUUN3ME21MlUxPTJizszN NEXS[5RUSU6JRWK=
ONS-76 MlnsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTVwNUW4NFEh|ryP MlPEV2FPT0WU
Ca-Ski MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXyZVlRUUN3ME21MlYzPTZ4IN88US=> MYjTRW5ITVJ?
COLO-741 NGO1XHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\6XGxKSzVyPUWuO|E6QTVizszN M2HzW3NCVkeHUh?=
HT-29 NEKwbHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLSTZlKSzVyPUWuPFA1PzVizszN MljOV2FPT0WU
HCC1187 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXwWHFKSzVyPUWuPFExODhizszN NUO0bYU6W0GQR1XS
Capan-2 NYT3fVZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7ITWM2OD13Lkm1PVk1KM7:TR?= MV7TRW5ITVJ?
NCI-H630 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml33TWM2OD14LkGxOFQyKM7:TR?= MVjTRW5ITVJ?
COLO-678 NXLkVXo2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\3XmlEPTB;Nj6xOVA6OiEQvF2= NH7WeJdUSU6JRWK=
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GBM2 NEXZfnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfIT|lKSzVyPUSwMlchdk1? NHPHSmYzOTN|N{[3PS=>
NB-1643 NWj3dXk4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTkTpI1UUN3ME2zN{45KG6P M4HXelIyOzN5Nke5
NB-EBc1 MnHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7odplOUUN3ME2yO{4yKG6P M2DiNVIyOzN5Nke5
CHLA-90 M1PjUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofHTWM2OD1|ND61JI5O NYe4WZM5OjF|M{e2O|k>
CHLA-136 NUDzT|hQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXLTWM2OD1zNkKuOkBvVQ>? NHXRPGUzOTN|N{[3PS=>
NALM-6 M{DYOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTRd|h6UUN3ME2zNk46KG6P NFL5bVkzOTN|N{[3PS=>
COG-LL-317 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3lTWM2OD1zLkOgcm0> MYKyNVM{PzZ5OR?=
RS4;11 NWTGWY9PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHPb4FKSzVyPUO1JI5O MnfiNlE{Ozd4N{m=
MOLT-4 Mn;oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3[0UmlEPTB;OD62JI5O NFLiWGczOTN|N{[3PS=>
CCRF-CEM MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvsNFZKSzVyPUSuNUBvVQ>? NUPVUphOOjF|M{e2O|k>
Kasumi-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTFwNDDuUS=> MnXENlE{Ozd4N{m=
Karpas-299 MnzuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTJzLkegcm0> M1v4UVIyOzN5Nke5
Ramos-RA1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRThwMjDuUS=> NUOxOphjOjF|M{e2O|k>
H838 MkfNSpVv[3Srb36gRZN{[Xl? NGXQVocyKM7:TR?= M{TnSlQ5KGh? Mn\ZbY5lfWOnczDj[YxtKGG3dH;wbIFogQ>? M3;acVIxOzZ2MUGz
H838 Mmq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mle4NE0{KM7:TR?= MXy3NkBp NH;yO3BqdmS3Y3XzJIdzd3e2aDDpcohq[mm2aX;uJIFv\CCjdYTvdIhi\3l? MWOyNFAzQDh3NB?=
A549  NGrJcVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DvS|AuOyEQvF2= NGrKW5E4OiCq NV7yUXpmcW6mdXPld{Boem:5dHigbY5pcWKrdHnvckBidmRiYYX0c5Bp[We7 NULDepk1OjByMki4OVQ>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-mTOR / p-AKT / p-4EBP1 / p-P70S6K / p-PRAS40; 

PubMed: 24457069     


Western blots of 70% confluent TamR (A) and MCF7-X (B) cells treated for 15 minutes to 24 hours with AZD8055 (0 to 100 nM). Blots were probed with phospho- and total antibodies for mTORC1 and two signalling pathways. In both cell lines mTORC1 and mTORC2 s䲧疝Ỵ疞㧀疜膉痘 瘿삨ՂᾰƌՂĀ 㺣痖帉痖Ѐ瑖堘𢡄빢᎒ՂĀ鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙

p-EGFR / EGFR; 

PubMed: 25654224     


PANC-1 cells were treated with AZD8055 for the indicated hours and EGFR (T/P), AKT (T/P) and ribosomal protein S6 (S6) (T/P) proteins were examined by western-blot;

p-FOXO1 / FOXO1 / p-FOXO3a / FOXO3a ; 

PubMed: 25654224     


PANC-1 cells were transfected with FoxO1/FoxO3a siRNAs and treated with AZD8055 for 1 h, then AKT (T/P), FoxO1 (T/P), FoxO3a (T/P) and EGFR (T/P) proteins were examined by western-blot.

24457069 25654224
Immunofluorescence
p-4EBP1 / EIF4E / mTOR; 

PubMed: 24600487     


(C) Hoechst 33258 staining of Hep-2 cells after treatment with AZD8055 for 24 hours were shown. The cells were fixed and immunereacted with anti-mTOR antibody followed by incubation with Alexa 488-labeled secondary antibody (C-F). Images were taken by a c䲧疝Ỵ疞㧀疜膉痘 瘿삨ՂᾰƌՂĀ 㺣痖帉痖Ѐ瑖堘𢡄빢᎒ՂĀ鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ�෋䐺痖暼瘿�෋ᾰƌ �෋à㺣痖�෋€𢡄�෋€䀷痗�෋౴�෋㵶痗�෋뺖᎒泌Itemセ᎒Count﫨呂�෋猴፲�෋፲씢痗猸፲髸莤䥷堙᎒セ᎒�堞ﻮ᎒፲露𢡄堚،齃礤v�堞ﻮ᎒猢Wセ᎒䨼Ą鹿齃殺獸W戀醙玛W戀ⶰ໯齃礤v 玚W玢Wⶰ໯﫰礌vtЉᔈැ鲬౴᥊疜犈፲Eo狜፲艘ᎂ艘ᎂ⩈̎䥠̌씢痗狠፲붖᎒i變ﱘ﫰﬐먙堘붖᎒狠፲i變ﱘ﫰먰堘ﱘ붖᎒�堞봆᎒릎堘붖᎒i꣩쯟巰痗ꣵ쯟巰痗Љ镴౴￿￿嶴痗Љ镨౴ᔈැ竗ᔈැ屷痗W竗尊痗

LC3B / p62 ; 

PubMed: 30337536     


Immunofluorescence staining of U87 and U251 GICs, which treated by DMSO, AZD8055 (0.3 μM) and rapamycin (3 μM). The nuclei were stained with DAPI and the antibody against LC3B and p62. Images were captured by laser confocal microscope ( × 400), scale bar 䲧疝Ỵ疞

24600487 30337536
Growth inhibition assay
Cell viability ; 

PubMed: 29263324     


Growth for the indicated cell lines was assessed after 72 h of treatment with AZD8055 (0–250 nM). Results are expressed as a percentage of cell number relative to the DMSO-treated control cells a.

29263324
体内研究 AZD8055 按2.5/10 mg/kg剂量作用于U87MG和A549移植瘤抑制pS6和pAKT,导致肿瘤生长受抑制。AZD8055按10/20 mg/kg剂量处理多种移植瘤包括U87MG, BT474c, A549, Calu-3, LoVo, SW620, PC3和MES-SA时,显示出明显的抗癌活性。[1] AZD8055诱导肿瘤体积下降约40%, 伴随着AKT, S6K,和SGK蛋白激酶磷酸化的切除。用AZD8055 (5mg/kg, 每天2次) 和SAHA (100 mg/kg/每天)处理PTEN+/−LKB1+/hypo 移植瘤,导致肿瘤生长全部受抑制,且对鼠mTORC1和mTORC2信号抑制没有副作用。[4]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[1]
- 合并

抑制mTOR的细胞为基础的测定实验:

通过高通量筛选细胞检测法,使用MDA-MB-468细胞,测定mTORC1 和mTORC2活性。用增加浓度的AZD8055处理细胞2小时。温育到最后时,细胞进行固定,冲洗,用p-Akt(S473)抗体和p-S6(S235/236)抗体探测。用激光扫描仪检测磷酸化水平。
细胞实验:[1]
- 合并
  • Cell lines: U87MG, A549,和H838 细胞
  • Concentrations: 溶解在DMSO中,作为10 mM 储备液, 0.001-1.0 μM
  • Incubation Time: 72到96小时
  • Method: 用AZD8055处理细胞72到96小时, 用0.03 mg/mL Hoechst 33342染色细胞核,用1 μg/mL 吖啶橙染色酸性小囊泡染色。通过ArrayScan II平台在450和536纳米处获得图像,测量酸性小囊泡的百分数和细胞数量。进行LC3测评,用10 μg/mL e64d/抑肽素处理细胞30 到90分钟,然后和AZD8055温育。细胞溶解在冰上,通过免疫印迹法分析。
    (Only for Reference)
动物实验:[1]
- 合并
  • Animal Models: U87MG, BT474c, A549, Calu-3, LoVo, SW620, PC3 and MES-SA U87-MG和A549细胞建立在无病原体,雌性裸鼠体内(nu/nu:Alpk)。
  • Dosages: 2.5-20 mg/kg
  • Administration: 口服饲喂,每天1到2次。
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 50 mg/mL warmed (107.4 mM)
Water Insoluble
Ethanol '3 mg/mL
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
4% DMSO+30% PEG 300+ddH2O
5mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 465.54
化学式

C25H31N5O4

CAS号 1009298-09-2
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

mTOR Signaling Pathway Map

mTOR Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID