Sorafenib (BAY 43-9006)

For research use only. Not for use in humans.

目录号:S7397 别名: NSC-724772 中文名称:索拉非尼

Sorafenib (BAY 43-9006) Chemical Structure

CAS No. 284461-73-0

Sorafenib (BAY 43-9006, NSC-724772)是Raf-1B-Raf的多重激酶抑制剂,无细胞试验中IC50分别为6 nM和22 nM。Sorafenib 还可抑制VEGFR-2VEGFR-3PDGFR-βFlt-3c-KIT,对应的IC50值分别为90 nM、20 nM、57 nM、59 nM和68 nM。Sorafenib 可诱导autophagyapoptosis并激活ferroptosis,Sorafenib 具有抗肿瘤活性。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1302.66 现货
RMB 1205.41 现货
RMB 2214.52 现货
RMB 5503.41 现货
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客户使用Selleck生产的Sorafenib (BAY 43-9006)发表文献397篇:

产品安全说明书

Raf抑制剂选择性比较

生物活性

产品描述 Sorafenib (BAY 43-9006, NSC-724772)是Raf-1B-Raf的多重激酶抑制剂,无细胞试验中IC50分别为6 nM和22 nM。Sorafenib 还可抑制VEGFR-2VEGFR-3PDGFR-βFlt-3c-KIT,对应的IC50值分别为90 nM、20 nM、57 nM、59 nM和68 nM。Sorafenib 可诱导autophagyapoptosis并激活ferroptosis,Sorafenib 具有抗肿瘤活性。
靶点
Raf-1 [1]
(Cell-free assay)
mVEGFR2(Flk1) [1]
(Cell-free assay)
mVEGFR3 [1]
(Cell-free assay)
B-Raf [1]
(Cell-free assay)
B-Raf (V599E) [1]
(Cell-free assay)
6 nM 15 nM 20 nM 22 nM 38 nM
体外研究

Sorafenib抑制野生型和V599E突变型B-Raf活性,IC50分别为22 nM 和 38 nM。Sorafenib也能有效抑制mVEGFR2 (Flk-1),mVEGFR3,mPDGFRβ,Flt3,和c-Kit,IC50分别为15 nM,20 nM,57 nM,58 nM,和68 nM。Sorafenib 能够较弱地抑制FGFR-1,IC50 为580 nM。Sorafenib对ERK-1,MEK-1,EGFR,HER-2,IGFR-1,c-Met,PKB,PKA,cdk1/cyclinB,PKCα,PKCγ,和pim-1没有活性。Sorafenib显著抑制NIH 3T3细胞中VEGFR2磷酸化,IC50 为 30 nM,也会抑制HEK-293细胞中Flt-3磷酸化,IC50 为20 nM。Sorafenib有效阻断大多数细胞中MEK 1/2 和 ERK 1/2磷酸化,但不阻断A549 或 H460细胞中该过程,同时不影响PKB通路的抑制。Sorafenib抑制HAoSMC 和 MDA-MB-231细胞的增殖,IC50分别为0.28 μM 和 2.6 μM。[1]除了抑制RAF/MEK/ERK信号通路,Sorafenib tosylate显著抑制eIF4E的磷酸化作用,并以MEK/ERK依赖的方式下调肝癌(HCC)细胞中Mcl-1水平。Sorafenib 抑制PLC/PRF/5 和HepG2细胞的增殖,IC50分别为6.3 μM 和 4.5 μM,并诱导显著的细胞凋亡。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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HepG2 M3XCSWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MkXZTWM2OCB;IEKuPFQh|ryP NVLOU2RVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyOFI2PTNpPkK4NlQzPTV|PD;hQi=>
U937 NGLjS3lIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NF;pWlNIUTVyIE2gNk45PSEQvF2= MnrJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyMUS3OVUoRjJ{MEG0O|U2RC:jPh?=
A549 MlLIR5l1d3SxeHnjbZR6KGG|c3H5 M{G1VmlEPTBiPTCyMlkzKM7:TR?= Mn7TQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7Mke4NFEoRjJ6OUK3PFAyRC:jPh?=
A549 MWrDfZRwfG:6aXPpeJkh[XO|YYm= MU\JR|UxKD1iMj65NkDPxE1? MlzoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5N{ewNFkoRjJ5N{e3NFA6RC:jPh?=
ZR75-30 M3nFcmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWHGc2xjUUN3MDC9JFIvQTZizszN MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTFyMkG3OUc,OjlzMEKxO|U9N2F-
PC3 MljGR5l1d3SxeHnjbZR6KGG|c3H5 M3X6fmlEPTBiPTCzMlA{KM7:TR?= MkjFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh|NEC5NVMoRjJ6M{SwPVE{RC:jPh?=
MDA-MB-231 M{jmZmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MVTJR|UxKD1iMz6wPEDPxE1? NWX2RXZWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[5PVE6OzhpPkK2PVkyQTN6PD;hQi=>
A549 MnH2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlTBTWM2OCB;IEOuNUDPxE1? MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTFyMkG3OUc,OjlzMEKxO|U9N2F-
K562 MYHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{PocWdKPTBiPTCzMlE3KM7:TR?= MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
MOLT4 NH62T3BIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWrHTVUxKD1iMz6xOkDPxE1? NYTiR|F1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
A549/ATCC Ml\OS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHT2cZhIUTVyIE2gN{4yPiEQvF2= NYf5NmpuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
RPMI8226 NUXTOJB4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXzUS2khRSB|LkG2JO69VQ>? MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
SR MoL2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkjBS2k2OCB;IEOuNVYh|ryP M{jlOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
HOP62 NWSxOGgzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2DHPXRIUSB;IEOuNVYh|ryP NF;0UWc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
NCI-H226 MWDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUHGSI1rXEeLIE2gN{4yPiEQvF2= MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
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COLO205 M{[1VWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1jmcnRIUSB;IEOuNVYh|ryP MkjGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
M14 M4fBWWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoH2WGdKKD1iMz6xOkDPxE1? NUPJc5VCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
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786-0 MlnQS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mn21S2k2OCB;IEOuNVYh|ryP Mn74QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
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HCT15 M1nZO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnzJWGdKKD1iMz6xOkDPxE1? M1nrUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
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BT549 M4XLdmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmPBS2k2OCB;IEOuNVYh|ryP Ml;TQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
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A549 MnXhR5l1d3SxeHnjbZR6KGG|c3H5 MWHHTVUxKD1iMz6xOkDPxE1? Mk\FQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3OUC1NFgoRjJ4NUmwOVA5RC:jPh?=