Sorafenib (BAY 43-9006)

For research use only. Not for use in humans.

目录号:S7397 别名: NSC-724772 中文名称:索拉非尼

Sorafenib (BAY 43-9006) Chemical Structure

CAS No. 284461-73-0

Sorafenib (BAY 43-9006, NSC-724772)是Raf-1B-Raf的多重激酶抑制剂,无细胞试验中IC50分别为6 nM和22 nM。Sorafenib 还可抑制VEGFR-2VEGFR-3PDGFR-βFlt-3c-KIT,对应的IC50值分别为90 nM、20 nM、57 nM、59 nM和68 nM。Sorafenib 可诱导autophagyapoptosis并激活ferroptosis,Sorafenib 具有抗肿瘤活性。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1302.66 现货
RMB 1205.41 现货
RMB 2214.52 现货
RMB 5503.41 现货
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客户使用Selleck生产的Sorafenib (BAY 43-9006)发表文献369篇:

产品安全说明书

Raf抑制剂选择性比较

生物活性

产品描述 Sorafenib (BAY 43-9006, NSC-724772)是Raf-1B-Raf的多重激酶抑制剂,无细胞试验中IC50分别为6 nM和22 nM。Sorafenib 还可抑制VEGFR-2VEGFR-3PDGFR-βFlt-3c-KIT,对应的IC50值分别为90 nM、20 nM、57 nM、59 nM和68 nM。Sorafenib 可诱导autophagyapoptosis并激活ferroptosis,Sorafenib 具有抗肿瘤活性。
靶点
Raf-1 [1]
(Cell-free assay)
mVEGFR2(Flk1) [1]
(Cell-free assay)
mVEGFR3 [1]
(Cell-free assay)
B-Raf [1]
(Cell-free assay)
B-Raf (V599E) [1]
(Cell-free assay)
6 nM 15 nM 20 nM 22 nM 38 nM
体外研究

Sorafenib抑制野生型和V599E突变型B-Raf活性,IC50分别为22 nM 和 38 nM。Sorafenib也能有效抑制mVEGFR2 (Flk-1),mVEGFR3,mPDGFRβ,Flt3,和c-Kit,IC50分别为15 nM,20 nM,57 nM,58 nM,和68 nM。Sorafenib 能够较弱地抑制FGFR-1,IC50 为580 nM。Sorafenib对ERK-1,MEK-1,EGFR,HER-2,IGFR-1,c-Met,PKB,PKA,cdk1/cyclinB,PKCα,PKCγ,和pim-1没有活性。Sorafenib显著抑制NIH 3T3细胞中VEGFR2磷酸化,IC50 为 30 nM,也会抑制HEK-293细胞中Flt-3磷酸化,IC50 为20 nM。Sorafenib有效阻断大多数细胞中MEK 1/2 和 ERK 1/2磷酸化,但不阻断A549 或 H460细胞中该过程,同时不影响PKB通路的抑制。Sorafenib抑制HAoSMC 和 MDA-MB-231细胞的增殖,IC50分别为0.28 μM 和 2.6 μM。[1]除了抑制RAF/MEK/ERK信号通路,Sorafenib tosylate显著抑制eIF4E的磷酸化作用,并以MEK/ERK依赖的方式下调肝癌(HCC)细胞中Mcl-1水平。Sorafenib 抑制PLC/PRF/5 和HepG2细胞的增殖,IC50分别为6.3 μM 和 4.5 μM,并诱导显著的细胞凋亡。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MV-4-11 NFXoe5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfyPGxKSzVyPUCuNFAxODB|MEOg{txO MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxN|M3Nyd-U1HOS2VTRC:jPh?=
MONO-MAC-6 NEDKdWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlP0TWM2OD1yLkCwOFE5KM7:TR?= Mo\iQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVM{Pi9pPmPBUmdGWjxxYU6=
ALL-PO MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUexVmZnUUN3ME2wMlA{OTh2IN88US=> MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxN|M3Nyd-U1HOS2VTRC:jPh?=
NKM-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEm2OFVKSzVyPUCuNFc1OTZizszN NYHoR29rRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTN|Nj:nQnNCVkeHUkyvZV4>
CGTH-W-1 NHjQfodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTBwMkWwNlIh|ryP Mn3VQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVM{Pi9pPmPBUmdGWjxxYU6=
BB65-RCC NXv0e3dUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwNEewO|Mh|ryP MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxN|M3Nyd-U1HOS2VTRC:jPh?=
NOS-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwNU[zOkDPxE1? NFrteJc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
SH-4 M4DDPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TCb2lEPTB;MD62OVYyOyEQvF2= MnzEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVM{Pi9pPmPBUmdGWjxxYU6=
HOP-62 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTBwOEWwPFgh|ryP NFPDVXQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
HCC2998 NEXxSmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\t[oNVUUN3ME2wMlg5QDF6IN88US=> NVPkVGZVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTN|Nj:nQnNCVkeHUkyvZV4>
GDM-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\WOYJKSzVyPUCuPVA3QThizszN MnnMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVM{Pi9pPmPBUmdGWjxxYU6=
KM12 Mn23S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTFwMEKwPVgh|ryP M1X5fVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE{OzZxJ{7TRW5ITVJ:L3G+
LB2518-MEL NEXzcWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TSVWlEPTB;MT6yNFgxQSEQvF2= NHn3OIY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
NCI-H1436 NHuyc5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jq[mlEPTB;MT6yNVY4QCEQvF2= M4e4dFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE{OzZxJ{7TRW5ITVJ:L3G+
EM-2 NXPkZpkzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTFwM{W1O|gh|ryP M4nld|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE{OzZxJ{7TRW5ITVJ:L3G+
LAMA-84 M4TId2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XKdWlEPTB;MT6zO|Y1QCEQvF2= NGXhSIU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
KG-1 M{SzNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTFwNEe5N|Uh|ryP M{TKRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE{OzZxJ{7TRW5ITVJ:L3G+
A388 NVzrN3VDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTFwNUmxOlUh|ryP NFfB[IE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
no-10 NVTOeYJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvn[XlwUUN3ME2xMlYyPzJ4IN88US=> MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxN|M3Nyd-U1HOS2VTRC:jPh?=
SF126 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDVTWM2OD1zLk[zPFEzKM7:TR?= NWnm[o4{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTN|Nj:nQnNCVkeHUkyvZV4>
MEG-01 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjMTWM2OD1zLkiwPVgh|ryP NI[w[IQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
A3-KAW MlnKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjpTWM2OD1zLki4OFIh|ryP NHjYT4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
D-247MG MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3TTWM2OD1{LkG0OFgh|ryP M2TYSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE{OzZxJ{7TRW5ITVJ:L3G+
OVCAR-4 NHPkOVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXaTWM2OD1{LkKxN|k{KM7:TR?= NXLVW3BHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTN|Nj:nQnNCVkeHUkyvZV4>
NCI-SNU-1 MnP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\pTWM2OD1{LkOxOlIh|ryP NWrEZmRYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTN|Nj:nQnNCVkeHUkyvZV4>
NCI-H2171 Mm\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTJwM{m3OlQh|ryP MlywQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVM{Pi9pPmPBUmdGWjxxYU6=
SIG-M5 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7BPIR4UUN3ME2yMlQzOjR{IN88US=> Ml\RQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVM{Pi9pPmPBUmdGWjxxYU6=
BE-13 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTJwNkm2NFkh|ryP MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxN|M3Nyd-U1HOS2VTRC:jPh?=
K052 NXvmdWdWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPrXIQxUUN3ME2yMlc1PjF4IN88US=> MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxN|M3Nyd-U1HOS2VTRC:jPh?=
L-540 MmfIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTJwN{W3PFkh|ryP NIX2dnM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
KMOE-2 MlrIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTDUHlZUUN3ME2yMlgyOzVizszN MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxN|M3Nyd-U1HOS2VTRC:jPh?=
MFH-ino MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXX2SnZUUUN3ME2yMlkzOTh3IN88US=> NXTtb3V1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTN|Nj:nQnNCVkeHUkyvZV4>
HL-60 MnfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfDdmNzUUN3ME2zMlA3Ojl7IN88US=> NF62VG49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
HCC2218 MlToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjxRXJYUUN3ME2zMlEzODB|IN88US=> MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxN|M3Nyd-U1HOS2VTRC:jPh?=
TE-5 NXnIeYdXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PxSWlEPTB;Mz6xN|E3OiEQvF2= NGntNpE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
MZ1-PC NF7ndYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XqOGlEPTB;Mz60O|UxQSEQvF2= MlPOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVM{Pi9pPmPBUmdGWjxxYU6=
MRK-nu-1 NF6wS3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoizTWM2OD1|Lk[xOFY5KM7:TR?= NFXL[3I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
MZ7-mel NH3NRlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfoVItKSzVyPUOuOlYxQTlizszN NU\C[4J4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTN|Nj:nQnNCVkeHUkyvZV4>
BC-1 NHKz[oJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PNOGlEPTB;Mz63OFAzKM7:TR?= MmfZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVM{Pi9pPmPBUmdGWjxxYU6=
ST486 NEfkc2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTUNIdKSzVyPUOuPFM3PzNizszN NV3xb3lzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTN|Nj:nQnNCVkeHUkyvZV4>
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Spodoptera frugiperda M1fi[2Z2dmO2aX;uJIF{e2G7 NXn0e3BbUUN3MDC9JFAvODlizszN MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjl{MkKyPEc,OjZ7MkKyNlg9N2F-
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K562 NX6zTlk1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MXHJR|UxKD1iMD64OkDPxE1? MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDNzNUG5Nkc,OjR|MUWxPVI9N2F-
COLO205 NF\jXYtCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M4SxT2lEPTBiPTCwMlg4KM7:TR?= M1\td|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{e4PVk2Lz5{NUe3PFk6PTxxYU6=
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F-6-8 Ml[xR5l1d3SxeHnjbZR6KGG|c3H5 NGTiRXJKSzVyIE2gNU4{KM7:TR?= NXHycWtJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zNVg6QThpPkK2N|E5QTl6PD;hQi=>
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rhabdomyosarcoma NHL6O3FCdnSrdnnyZYwh[WO2aY\peJkh[XO|YYm= MW\FR|UxKD1iMT61JO69VQ>? M4LMRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5Mki4NVg3Lz5{N{K4PFE5PjxxYU6=
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HCT116 Moj1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NH3SfVNIUTVyIE2gNU42QCEQvF2= MnfQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
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SF539 MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NF\YS4JIUTVyIE2gNU42QCEQvF2= MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
UACC62 MmrRS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4DoXWdKPTBiPTCxMlU5KM7:TR?= MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
SF295 NEmyZ5JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3j4O2dKPTBiPTCxMlU5KM7:TR?= M3rzWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
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HL-60(TB) NWHYdXV5S3m2b4TvfIlkcXS7IHHzd4F6 MlPPS2k2OCB;IEGuOVgh|ryP NX;NeYJURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[1PVA2ODhpPkK2OVkxPTB6PD;hQi=>
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SF539 M1HyVGN6fG:2b4jpZ4l1gSCjc4PhfS=> MofKS2k2OCB;IEGuOVgh|ryP NHXCOGU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
SK-MEL-2 M2nRN2N6fG:2b4jpZ4l1gSCjc4PhfS=> MYnHTVUxKD1iMT61PEDPxE1? NHy3Vlk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
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KM12 NFLaPYdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MlLnS2k2OCB;IEGuOVgh|ryP NFXabZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
MDA-MB-435 Mlj6RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NXT3RVRkT0l3MDC9JFEvPThizszN MoXVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
SF539 NIPSXIxCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MmG4S2k2OCB;IEGuOVgh|ryP NUjEfmoyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
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HCT116 MYDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MWXHTVUxKD1iMT61PEDPxE1? Ml7UQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
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NCI-H522 NEfrO41Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXvsU3BnT0l3MDC9JFIh|ryP MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
HOP62 NETCeJZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4r3eWdKPTBiPTCyJO69VQ>? MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
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Hep3B NYTZOXluT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4DrfmlEPTBiPTCyMlY{KM7:TR?= NHPCbZk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUGwNlE4PSd-MkmxNFIyPzV:L3G+
A375P M4S2cGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M4rXcmlEPTBiPTCyMlch|ryP M2Pwe|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NE[wNFMxLz5{MkS2NFA{ODxxYU6=
U937 MnrFRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NUX2eY5ET0l3MDC9JFIvPzRizszN NVT6ZllQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zNVgxPjdpPkK2N|E5ODZ5PD;hQi=>
U937 M{fUcGN6fG:2b4jpZ4l1gSCjc4PhfS=> MUnHTVUxKD1iMj63OEDPxE1? M2nENVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEe4NVk{Lz5{NEi3PFE6OzxxYU6=
MCF7 NYPHbnZVT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NInBS2pKSzVyIE2gNk44QCEQvF2= MmPGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlzMEKxO|UoRjJ7MUCyNVc2RC:jPh?=
MDA-MB-231 M{HoR2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NGnEb5pKSzVyIE2gNk45KM7:TR?= MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTJyMkSwN{c,Ojl{MEK0NFM9N2F-
HepG2 MmC1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M1HJfWlEPTBiPTCyMlg1KM7:TR?= MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJ2MkW1N{c,Ojh{NEK1OVM9N2F-
U937 MoHRS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkPSS2k2OCB;IEKuPFUh|ryP MkSxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyMUS3OVUoRjJ{MEG0O|U2RC:jPh?=
A549 MnP6R5l1d3SxeHnjbZR6KGG|c3H5 MYLJR|UxKD1iMj65NkDPxE1? MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl{N{iwNUc,Ojh7Mke4NFE9N2F-
A549 NHLUXWREgXSxdH;4bYNqfHliYYPzZZk> Mo\vTWM2OCB;IEKuPVIh|ryP M1zS[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{e3NFA6Lz5{N{e3O|AxQTxxYU6=
ZR75-30 MljES5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmLWTWM2OCB;IEKuPVYh|ryP NF\RbnM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUGwNlE4PSd-MkmxNFIyPzV:L3G+
PC3 Moj4R5l1d3SxeHnjbZR6KGG|c3H5 MXLJR|UxKD1iMz6wN{DPxE1? MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDN2MEmxN{c,Ojh|NEC5NVM9N2F-
MDA-MB-231 M1XCOGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NILiWYpKSzVyIE2gN{4xQCEQvF2= MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjl7MUmzPEc,OjZ7OUG5N|g9N2F-
A549 M{L3bGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYrjdZNiUUN3MDC9JFMvOSEQvF2= M{jQNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MUCyNVc2Lz5{OUGwNlE4PTxxYU6=
K562 M3W4bGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlnlS2k2OCB;IEOuNVYh|ryP NH7IWFY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
MOLT4 NVr5V2NPT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NV7hTm53T0l3MDC9JFMvOTZizszN NV7vZ2JWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
A549/ATCC MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4\3WWdKPTBiPTCzMlE3KM7:TR?= MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
RPMI8226 MoC4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoLxWGdKKD1iMz6xOkDPxE1? NV7adWFLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
SR MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUH5OnpUT0l3MDC9JFMvOTZizszN NH6wUmM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
HOP62 NEfCTnhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUfxT|c1XEeLIE2gN{4yPiEQvF2= M3SxTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
NCI-H226 NEjYTWxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYPtdoNsXEeLIE2gN{4yPiEQvF2= NIfuUnY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
U251 MoLkS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3PaWHRIUSB;IEOuNVYh|ryP NHfRZ|g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
COLO205 NIXEfIRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmnKWGdKKD1iMz6xOkDPxE1? NVXxNpR{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
M14 Mnf5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MorRWGdKKD1iMz6xOkDPxE1? NWPKXG1ERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
HCC2998 NVfVTYVrT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkXIS2k2OCB;IEOuNVYh|ryP NIS1VIQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
SNB75 MkTvS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUXHTVUxKD1iMz6xOkDPxE1? MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
786-0 NHPkToJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWjHTVUxKD1iMz6xOkDPxE1? MmS0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
A498 MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnvQWGdKKD1iMz6xOkDPxE1? MkXqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
HCT15 NV\ZRZd5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFfUfpdVT0liPTCzMlE3KM7:TR?= MlHyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
OVCAR3 MlnNS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M33iVmdKPTBiPTCzMlE3KM7:TR?= NHTzWnU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
OVCAR4 NI\EXm5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVHHTVUxKD1iMz6xOkDPxE1? MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
Caki1 M4XH[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIXR[Y1IUTVyIE2gN{4yPiEQvF2= MmqzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
SNB19 Mn3pS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmXCS2k2OCB;IEOuNVYh|ryP MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
OVCAR5 NGC2dnJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWL1fZQ5T0l3MDC9JFMvOTZizszN M4rF[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
DU145 NHTEXVBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3rWd2dKPTBiPTCzMlE3KM7:TR?= NVrMcXlkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
OVCAR8 M3HQfGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlKyS2k2OCB;IEOuNVYh|ryP MmHyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
SN12C Ml\MS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYPUS2khRSB|LkG2JO69VQ>? M2fPSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
MDA-MB-231 M2jLZmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVjUS2khRSB|LkG2JO69VQ>? NEPaclA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
RXF393 M1;hPGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYXQWmJFT0l3MDC9JFMvOTZizszN MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
BT549 M2S2VGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MU\HTVUxKD1iMz6xOkDPxE1? Moj1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
K562 M1fsTmN6fG:2b4jpZ4l1gSCjc4PhfS=> M{nrSWdKPTBiPTCzMlE3KM7:TR?= MoH4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3OUC1NFgoRjJ4NUmwOVA5RC:jPh?=
MOLT4 NVPDVpBsS3m2b4TvfIlkcXS7IHHzd4F6 MnfQS2k2OCB;IEOuNVYh|ryP Mo\hQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3OUC1NFgoRjJ4NUmwOVA5RC:jPh?=
SNB19 MnTDR5l1d3SxeHnjbZR6KGG|c3H5 NXHSd3o1T0l3MDC9JFMvOTZizszN NXX1UotzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[1PVA2ODhpPkK2OVkxPTB6PD;hQi=>
SR MoPWR5l1d3SxeHnjbZR6KGG|c3H5 NUTkV2NYT0l3MDC9JFMvOTZizszN MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV7MEWwPEc,OjZ3OUC1NFg9N2F-
A549 MnrLR5l1d3SxeHnjbZR6KGG|c3H5 MYrHTVUxKD1iMz6xOkDPxE1? MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV7MEWwPEc,OjZ3OUC1NFg9N2F-
OVCAR3 NX7TZlJzS3m2b4TvfIlkcXS7IHHzd4F6 MnTxS2k2OCB;IEOuNVYh|ryP NHmwXWo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
OVCAR4 MonQR5l1d3SxeHnjbZR6KGG|c3H5 MmT6S2k2OCB;IEOuNVYh|ryP MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV7MEWwPEc,OjZ3OUC1NFg9N2F-
SNB75 MmPCR5l1d3SxeHnjbZR6KGG|c3H5 NUnjPXY4T0l3MDC9JFMvOTZizszN NYTzb2t6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[1PVA2ODhpPkK2OVkxPTB6PD;hQi=>
OVCAR5 NHnnfoNEgXSxdH;4bYNqfHliYYPzZZk> MUfHTVUxKD1iMz6xOkDPxE1? NITEOnk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
DU145 NHXNUXdEgXSxdH;4bYNqfHliYYPzZZk> MnvXS2k2OCB;IEOuNVYh|ryP M{i4RVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NUmwOVA5Lz5{NkW5NFUxQDxxYU6=
786-0 MWXDfZRwfG:6aXPpeJkh[XO|YYm= NGm3fXhIUTVyIE2gN{4yPiEQvF2= NXvWZYhbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[1PVA2ODhpPkK2OVkxPTB6PD;hQi=>
BT549 MVfDfZRwfG:6aXPpeJkh[XO|YYm= NV7ZdYpRT0l3MDC9JFMvOTZizszN M1\5O|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NUmwOVA5Lz5{NkW5NFUxQDxxYU6=
ACHN Mn7WR5l1d3SxeHnjbZR6KGG|c3H5 MkHwS2k2OCB;IEOuNVYh|ryP NFG2O5o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
Caki1 MWnDfZRwfG:6aXPpeJkh[XO|YYm= MoHuS2k2OCB;IEOuNVYh|ryP MnKzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3OUC1NFgoRjJ4NUmwOVA5RC:jPh?=
786-0 NIT2XXZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NF7HN2xIUTVyIE2gN{4yPiEQvF2= Mnq0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
LOXIMVI NHW2W29CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MmHHWGdKKD1iMz6xOkDPxE1? M4XzflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
Caki1 MWDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NY\NSYVGT0l3MDC9JFMvOTZizszN NIry[W89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
OVCAR5 MoroRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MVjHTVUxKD1iMz6xOkDPxE1? NVXhOplORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
RXF393 NWT3NJAxSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M2rKOmdKPTBiPTCzMlE3KM7:TR?= Mn\wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
SNB75 MX7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NWmzOnMzT0l3MDC9JFMvOTZizszN MmPnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
OVCAR3 M1TWTWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NEH5XHlIUTVyIE2gN{4yPiEQvF2= MlzXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
SNB19 NFPVd4lCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NHzGXGZIUTVyIE2gN{4yPiEQvF2= NU\N[pprRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
SK-MEL-5 NILXUHZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NY\HUYV[XEeLIE2gN{4yPiEQvF2= M3LRXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
OVCAR4 NWTRRXc5SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MonyS2k2OCB;IEOuNVYh|ryP MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
SK-MEL-2 MmLORY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NELMNGpVT0liPTCzMlE3KM7:TR?= NGTpRWI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
BT549 NYXYNnA1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NIHIbmRIUTVyIE2gN{4yPiEQvF2= M3r2ZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
MOLT4 MofSRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? Mn[5S2k2OCB;IEOuNVYh|ryP M1;mflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
K562 MmLSRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M4DrdGdKPTBiPTCzMlE3KM7:TR?= MlXIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
HCC2998 MWDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M{HPbmdKPTBiPTCzMlE3KM7:TR?= NIDUXWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
HCC2998 MmfERY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MUTUS2khRSB|LkG2JO69VQ>? M{\qV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
A549/ATCC M2r1O2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NGnCNFFIUTVyIE2gN{4yPiEQvF2= MnXuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
DU145 NEDDR41CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MkjjS2k2OCB;IEOuNVYh|ryP M2XTSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
SR Mn7pRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NX3YN|htT0l3MDC9JFMvOTZizszN MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
MCF7 MUPDfZRwfG:6aXPpeJkh[XO|YYm= NW\6V3dqUUN3MDC9JFMvOThizszN NIfiVJc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEmyO|gxOSd-Mki5Nlc5ODF:L3G+
PC3 M2PvcGN6fG:2b4jpZ4l1gSCjc4PhfS=> NEXXbW5KSzVyIE2gN{4yQCEQvF2= MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl{N{iwNUc,Ojh7Mke4NFE9N2F-
MCF7 NGKyWIVEgXSxdH;4bYNqfHliYYPzZZk> NWDqXmRUUUN3MDC9JFMvOThizszN M1XocVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{e3NFA6Lz5{N{e3O|AxQTxxYU6=
A549 NID1cWlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NXnlV5E2UUN3MDC9JFMvOTlizszN MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd5OEm5OUc,OjV5N{i5PVU9N2F-
PC3 MVTDfZRwfG:6aXPpeJkh[XO|YYm= MX;JR|UxKD1iMz6yOEDPxE1? M4\LSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{e3NFA6Lz5{N{e3O|AxQTxxYU6=
HeLa MoK5SpVv[3Srb36gZZN{[Xl? Mor5TWM2OCB;IEOuN{DPxE1? NXnBNnFQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUWyNlU4ODZpPkG1NlI2PzB4PD;hQi=>
HeLa MlLtSpVv[3Srb36gZZN{[Xl? NEjmOXZKSzVyIE2gN{4{KM7:TR?= NInkV|E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUKyOVcxPid-MUWyNlU4ODZ:L3G+
LoVo M{izU2N6fG:2b4jpZ4l1gSCjc4PhfS=> Mlv6TWM2OCB;IEOuN{DPxE1? Mlu4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2NUSwNVcoRjJ|NEW0NFE4RC:jPh?=
A375 MYfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MmTZTWM2OCB;IEOuN|Yh|ryP MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZyMk[3OEc,Ojl4MEK2O|Q9N2F-
HT-29 NVm5fWxoSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NHvRfW1KSzVyIE2gN{4{PyEQvF2= M3n4R|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OUmxPVM5Lz5{Nkm5NVk{QDxxYU6=
FLT3 gene-deficient U937 NXLLPIFvSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MofuS2k2OCB;IEOuOEDPxE1? NH71OmU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUewPFQ3QCd-MkG3NFg1Pjh:L3G+
FLT3 negative U937 M4TacGN6fG:2b4jpZ4l1gSCjc4PhfS=> M3jsXGdKPTBiPTCzMlQh|ryP M3HmUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkG4O|A6Lz5{M{[xPFcxQTxxYU6=
U937 NF\2VHdEgXSxdH;4bYNqfHliYYPzZZk> NXLGTWhjT0l3MDC9JFMvPCEQvF2= M3G1U|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MEixNFI{Lz5{NkC4NVAzOzxxYU6=
A375P M{TrUWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NV;vSpVvT0l3MDC9JFMvPCEQvF2= MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR3OUG0OEc,Ojl2NUmxOFQ9N2F-
ACHN MlPFR5l1d3SxeHnjbZR6KGG|c3H5 MXXJR|UxKD1iMz60JO69VQ>? NXXRcpEyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1NVc6ODhpPkK5OVE4QTB6PD;hQi=>
ACHN M1XZU2N6fG:2b4jpZ4l1gSCjc4PhfS=>