Torin 1

目录号:S2827

Torin 1 Chemical Structure

Molecular Weight(MW): 607.62

Torin 1是一种有效的mTORC1/2抑制剂,在无细胞试验中IC50为2 nM/10 nM;作用于mTOR比作用于PI3K选择性高1000倍。

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RMB 1419.84 现货
RMB 3019.04 现货
RMB 5492.28 现货
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客户使用Selleck该产品发表文献11篇:

客户使用该产品的5个实验数据:

  • Huh-7.5 cells were treated with increasing concentration of Torin 1, a known autophagy inducer, and the autophagy response was assessed by measuring LC3II and p62 levels.

    Am J Pathol 2014 184(1), 214-29. Torin 1 purchased from Selleck.

    Flag-tagged SENP3 was immunoprecipitated from HeLa cells and used for in vitro phosphorylation assay with [32P]ATP with either the mock-treated or Torin1-treated mTOR/Raptor/MLST8 complex. (Upper) The samples then were subjected to SDS-PAGE, followed by autoradiography. mTOR autophosphorylation is indicated by an asterisk. (Lower) Immunopurified SENP3 was monitored by Western blotting with anti-Flag antibody.

    Mol Cell Biol 2014 34(24), 4474-84. Torin 1 purchased from Selleck.

  • Exp Cell Res, 2018, 363(1):84-94. Torin 1 purchased from Selleck.

    Representative Western blots showing LC3 in PP242 (PP) or Torin1 (Tor) treated HepG2 cells. HepG2 cells were treated with 10 uM PP242 or 0.1 uM Torin1 for 24 h.

    Biochem Biophys Res Commun 2014 10.1016/j.bbrc.2014.05.047. Torin 1 purchased from Selleck.

  • Bone marrow derived macrophages were pre-treated with 10nM Torin 1 for 1h prior to LPS treatment (100 ng/ml). TNF-a production was analyzed 24h later.

    Lim Hsiu Kim, Lina from National University of Singapore. Torin 1 purchased from Selleck.

产品安全说明书

mTOR抑制剂选择性比较

生物活性

产品描述 Torin 1是一种有效的mTORC1/2抑制剂,在无细胞试验中IC50为2 nM/10 nM;作用于mTOR比作用于PI3K选择性高1000倍。
靶点
mTORC1 [1]
(Cell-free assay)
mTOR [2]
(Cell-free assay)
DNA-PK [2]
(Cell-free assay)
mTORC2 [1]
(Cell-free assay)
p110γ [2]
(Cell-free assay)
2 nM 4.32 nM 6.34 nM 10 nM 171 nM
体外研究

Torin1在2和10 nM浓度下分别抑制mTORC1 和mTORC2底物的磷酸化。此外,Torin1对mTOR比对PI3K (EC50 = 1800 nM)的选择性高1000倍,比对450种其它蛋白激酶的结合选择性高100倍。[1] [2] Torin1通过耐rapamycin机制引起细胞周期阻滞,并且其不依赖于mTORC2。Torin1比rapamycin更完全地干扰mTORC1依赖表现型。Cap依赖性翻译需要mTORC1耐Rapamycin的功能。[1]在近期的一项研究中,据报道Torin1通过活化人内分泌细胞系BON 中MEK/ERK/c-Jun通路,能够增加神经降压素分泌和基因表达。[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
ETK-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTBwMECwN|A3KM7:TR?= NGXjU41USU6JRWK=
OCUB-M MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlG4TWM2OD1yLkCwNVk1KM7:TR?= Mn2xV2FPT0WU
DOHH-2 NVPvPHlwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfwO5dKSzVyPUCuNFAzOjVizszN NVLy[WxXW0GQR1XS
NOS-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIn0eolKSzVyPUCuNFAzPDJizszN NXzXZ4tzW0GQR1XS
L-363 MnjDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\hVZVZUUN3ME2wMlAxOjh2IN88US=> M{TOWnNCVkeHUh?=
RL95-2 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzld|VKSzVyPUCuNFA{OiEQvF2= M3rEZXNCVkeHUh?=
BL-70 MmO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XxZWlEPTB;MD6wNFM{PyEQvF2= NV:xXlREW0GQR1XS
TGBC1TKB MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvLRWh4UUN3ME2wMlAxOzd7IN88US=> NY[1[4h7W0GQR1XS
697 M3Ln[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\jTWM2OD1yLkCwOlM1KM7:TR?= NGm0bGVUSU6JRWK=
RPMI-8226 NVfXc5RET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDHTWM2OD1yLkCwOlUyKM7:TR?= NE[3dZlUSU6JRWK=
BL-41 M4LNPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTBwMEC2PVYh|ryP MkTOV2FPT0WU
MRK-nu-1 NE\5RZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwMEC3NFch|ryP NUDuXIpIW0GQR1XS
EW-1 NEnEeHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLDXJhKSzVyPUCuNFA4PDlizszN Mk[4V2FPT0WU
EVSA-T NFHidoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTBwMEC4PVIh|ryP MofmV2FPT0WU
HUTU-80 NIr2WWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDxVYJKSzVyPUCuNFA6OjlizszN M3vRbHNCVkeHUh?=
VA-ES-BJ M3XKbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTBwMEC5PFQh|ryP NUDQXYFKW0GQR1XS
GCIY NYDCOWRvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;UTWM2OD1yLkCxNFA4KM7:TR?= M{\KPXNCVkeHUh?=
ES6 M4LlO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jYPWlEPTB;MD6wNVA5OyEQvF2= NWjuSFJlW0GQR1XS
NALM-6 M4LtRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELveG9KSzVyPUCuNFEyODJizszN M4PLbHNCVkeHUh?=
LB996-RCC M{Dpc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7ibldKSzVyPUCuNFEyOzdizszN NXj1fVlOW0GQR1XS
EW-16 NVXrbFhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYOzVnJiUUN3ME2wMlAyOTl{IN88US=> NWP3ZXdpW0GQR1XS
KALS-1 MnfpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjKToVKSzVyPUCuNFEyQThizszN NVnINHUzW0GQR1XS
OPM-2 MnH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\ZTWM2OD1yLkCxNlkh|ryP NGTnR45USU6JRWK=
KU812 NUWzNFBiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPHTWc3UUN3ME2wMlAyOjl4IN88US=> NXLQNZRiW0GQR1XS
A4-Fuk M1nWT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGn6T|lKSzVyPUCuNFE{OTlizszN NWT1ZnVvW0GQR1XS
KGN MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLKTWM2OD1yLkCxN|U6KM7:TR?= MY\TRW5ITVJ?
KS-1 NGPm[VNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLUV5I2UUN3ME2wMlAyOzl{IN88US=> MYHTRW5ITVJ?
no-11 M1;EdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjlXHpKSzVyPUCuNFE{QTVizszN NGrhSlFUSU6JRWK=
PSN1 MonLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTBwMEG0NFkh|ryP NHvDbY9USU6JRWK=
SK-LMS-1 M4nJTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwMEG0NVMh|ryP NGTQVXVUSU6JRWK=
LS-411N NV3pc|k1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\IVnJKSzVyPUCuNFE1OzlizszN MV3TRW5ITVJ?
HT-144 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGi1[W5KSzVyPUCuNFE1PTFizszN NVjqdIRLW0GQR1XS
ACN Ml7GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkG4TWM2OD1yLkCxOUDPxE1? NUPqbmVnW0GQR1XS
RKO M1HLdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7FTWM2OD1yLkCxOVM{KM7:TR?= MmfwV2FPT0WU
CMK M{DP[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXmyT|JRUUN3ME2wMlAyPTR|IN88US=> NWfZN|lnW0GQR1XS
GB-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\lNYFKSzVyPUCuNFE2PTNizszN M1;tZ3NCVkeHUh?=
KE-37 M1f5c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTaTWM2OD1yLkCxOVc{KM7:TR?= MnHNV2FPT0WU
no-10 NHfKOZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTZTWM2OD1yLkCxOVg1KM7:TR?= NIrDem9USU6JRWK=
MOLT-16 NFvn[5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TTdmlEPTB;MD6wNVYzOiEQvF2= NEfjcW1USU6JRWK=
HEL NUTvVFFXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfZVHZKSzVyPUCuNFE3PCEQvF2= NInEXJFUSU6JRWK=
NCI-H1355 MmS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml[zTWM2OD1yLkCxOlQ3KM7:TR?= MXzTRW5ITVJ?
IST-MEL1 M3rFdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTBwMEG3O|Qh|ryP NEmwUpZUSU6JRWK=
MHH-PREB-1 M1;rcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnITYNTUUN3ME2wMlAyQDF6IN88US=> MXHTRW5ITVJ?
ES8 M1n2Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mne2TWM2OD1yLkCxPFQ1KM7:TR?= NIjJcGlUSU6JRWK=
LC-2-ad MmroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonCTWM2OD1yLkCyNVM4KM7:TR?= MUnTRW5ITVJ?
LAMA-84 M3PhcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWO3UXhDUUN3ME2wMlAzOTZ5IN88US=> MkTFV2FPT0WU
BV-173 M{PiPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwMEKyNFMh|ryP Mmj4V2FPT0WU
SW872 M{TUbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2e5c2lEPTB;MD6wNlI1PyEQvF2= MkHCV2FPT0WU
SK-UT-1 M330Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfWTlFKSzVyPUCuNFIzPjFizszN NVnIOHA{W0GQR1XS
OS-RC-2 M4raWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjSSI1KSzVyPUCuNFI{OjNizszN M13GbnNCVkeHUh?=
NCI-H747 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHoTWM2OD1yLkCyN|Mh|ryP NFe1VG5USU6JRWK=
MZ2-MEL NEOz[JVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13v[2lEPTB;MD6wNlM{PyEQvF2= NX2yU3JUW0GQR1XS
TE-11 M{DZd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHT6N3JKSzVyPUCuNFI{PzJizszN NXrObXlDW0GQR1XS
KURAMOCHI NGDiVY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfpTWM2OD1yLkCyOFE1KM7:TR?= MljxV2FPT0WU
HD-MY-Z MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorXTWM2OD1yLkCyOFI3KM7:TR?= NVLDUGZKW0GQR1XS
GI-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlmzTWM2OD1yLkCyOFY6KM7:TR?= NYL1eXlKW0GQR1XS
LB1047-RCC MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXJTWM2OD1yLkCyOFg5KM7:TR?= NHvFXpBUSU6JRWK=
TE-12 NVjKcYptT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTBwMEK1OUDPxE1? M3rnU3NCVkeHUh?=
MZ7-mel M4LGNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojwTWM2OD1yLkCyOlA6KM7:TR?= NHrRdJdUSU6JRWK=
MMAC-SF NUK4SFVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rOPGlEPTB;MD6wNlY{OyEQvF2= NFPGTXlUSU6JRWK=
A101D MkHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjiT2FkUUN3ME2wMlAzPjVizszN MmfoV2FPT0WU
GR-ST MojrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;2ZVdXUUN3ME2wMlAzPjV3IN88US=> MnPwV2FPT0WU
MC116 MkS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTBwMEK2PEDPxE1? NWOzfG0xW0GQR1XS
Ramos-2G6-4C10 MnvWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDnUnNKSzVyPUCuNFI4PSEQvF2= NF;EOJdUSU6JRWK=
ATN-1 NF72cXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDoNnFKSzVyPUCuNFI4QDlizszN NYf4OlB7W0GQR1XS
MFH-ino NV72NWhKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXIUXFmUUN3ME2wMlAzQDF{IN88US=> NF3UUWhUSU6JRWK=
DEL M1zLXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfTUYlLUUN3ME2wMlAzQDF3IN88US=> NF;wRY5USU6JRWK=
OCI-AML2 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlj1TWM2OD1yLkCyPFcyKM7:TR?= NH\QSW9USU6JRWK=
LXF-289 NXvNb4p[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHMTWM2OD1yLkCyPFczKM7:TR?= MkCyV2FPT0WU
IA-LM NYrJ[Gs5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDuW5ZFUUN3ME2wMlAzQTF5IN88US=> NVeybY1uW0GQR1XS
EoL-1-cell MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\NSmlEPTB;MD6wNlk6PiEQvF2= MYjTRW5ITVJ?
OVCAR-4 MnXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvFO4hZUUN3ME2wMlA{ODl2IN88US=> MX;TRW5ITVJ?
ES1 NYnTbXF7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHMd3FKSzVyPUCuNFMxQTdizszN MVrTRW5ITVJ?
CESS NYXuVohzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjBUVVKSzVyPUCuNFMxQTlizszN MXzTRW5ITVJ?
GAK M2LBWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTBwMEOxPFYh|ryP MoG3V2FPT0WU
NTERA-S-cl-D1 MnLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTBwMEOyNlYh|ryP NX7NPGJUW0GQR1XS
TE-10 M3vDS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fOPWlEPTB;MD6wN|MyOSEQvF2= NYHHNHZIW0GQR1XS
CCRF-CEM NFnROlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3YTWM2OD1yLkCzN|cyKM7:TR?= NFHpbndUSU6JRWK=
NMC-G1 M2DYdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\2TItKSzVyPUCuNFM1PDhizszN Mn7IV2FPT0WU
HOP-62 NEjmbItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\WN4tKSzVyPUCuNFM2PTZizszN NF;iWpFUSU6JRWK=
SH-4 NHTLTmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4D6fWlEPTB;MD6wN|U5OiEQvF2= M3qwdnNCVkeHUh?=
NCI-H1648 NHHu[HRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYmxeo0xUUN3ME2wMlA{PjJ{IN88US=> Mk\UV2FPT0WU
EB-3 NH71e|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfacXBKSzVyPUCuNFM3PDNizszN MVfTRW5ITVJ?
BB65-RCC M2nDUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTsdJZKSzVyPUCuNFM3QTFizszN M{XscHNCVkeHUh?=
BE-13 NGHrdmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEG1XFJKSzVyPUCuNFM4PTlizszN M1vOSXNCVkeHUh?=
CP67-MEL M3viOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TMNmlEPTB;MD6wN|c2QSEQvF2= M4jSfHNCVkeHUh?=
SW954 NH\pXJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwMEO3PUDPxE1? MkTEV2FPT0WU
TE-5 MlnDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUW3d5R2UUN3ME2wMlA{QDV2IN88US=> NVzxTm5LW0GQR1XS
HCE-4 NF\ZOI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\GTWM2OD1yLkCzPFU2KM7:TR?= M3fw[XNCVkeHUh?=
LC-1F NGnG[pdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rxeWlEPTB;MD6wN|k5QSEQvF2= M1\lS3NCVkeHUh?=
TK10 NXzKXFVTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3MeFl3UUN3ME2wMlA1ODF7IN88US=> M4D3OHNCVkeHUh?=
SJSA-1 NXjKdJpzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmiyTWM2OD1yLkC0NVg5KM7:TR?= NHrUPY9USU6JRWK=
Daudi Mn;jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\wOGFKUUN3ME2wMlA1OjJ3IN88US=> NIjBeWlUSU6JRWK=
SW982 MlrDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjxSnpoUUN3ME2wMlA1OjR4IN88US=> NH\zfIpUSU6JRWK=
SF126 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jrXWlEPTB;MD6wOFM3OSEQvF2= MUHTRW5ITVJ?
TE-15 M2jXPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrIT5hKSzVyPUCuNFQ1OzVizszN MnriV2FPT0WU
COLO-684 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLTe5pSUUN3ME2wMlA1PTZzIN88US=> MVHTRW5ITVJ?
8-MG-BA M1\r[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NET1ZnBKSzVyPUCuNFQ3OjlizszN MYjTRW5ITVJ?
NB13 NYC1eYxnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTBwMES3O|Yh|ryP MWDTRW5ITVJ?
HCC1599 M1rHPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXpTWM2OD1yLkC0PFc6KM7:TR?= NVO2T2VVW0GQR1XS
SK-PN-DW MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTBwMES5OFkh|ryP MlWxV2FPT0WU
ALL-PO MoTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVL4OoM6UUN3ME2wMlA1QTV4IN88US=> MmS2V2FPT0WU
NB6 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlW1TWM2OD1yLkC1NlcyKM7:TR?= MVLTRW5ITVJ?
IST-SL2 NF[4c5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwMEWzOlIh|ryP MUfTRW5ITVJ?
BB30-HNC MnryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUn4R|FvUUN3ME2wMlA2PzNizszN NHrYZVJUSU6JRWK=
SW962 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITYWYdKSzVyPUCuNFU4PjNizszN MV;TRW5ITVJ?
TGBC24TKB MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\QTWlEPTB;MD6wOVc6QSEQvF2= MmXwV2FPT0WU
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HCC2157 Mn7PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4izU2lEPTB;MD6zN|k2PCEQvF2= MXfTRW5ITVJ?
LS-1034 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jpSGlEPTB;MD6zOlM5QCEQvF2= M2jsfnNCVkeHUh?=
BOKU MnK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUntXWJyUUN3ME2wMlM4OTl7IN88US=> MYfTRW5ITVJ?
GDM-1 MoXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX:yNFhTUUN3ME2wMlM4OjN2IN88US=> MWHTRW5ITVJ?
TGW NWTFRoFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXWTWM2OD1yLkO3OFU{KM7:TR?= M3rvcHNCVkeHUh?=
SNU-C1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HDRWlEPTB;MD6zPFIyPSEQvF2= NEj6VIlUSU6JRWK=
LS-513 NFLRU49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorqTWM2OD1yLkO5NFcyKM7:TR?= NYn5[HhSW0GQR1XS
NOMO-1 M3vnTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDoXoE6UUN3ME2wMlM6QTdzIN88US=> NUHIPFVJW0GQR1XS
MS-1 NEX3W3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwNECxO|ch|ryP M4n1dnNCVkeHUh?=
EKVX NITtS25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwNES0OlEh|ryP NEnCO|ZUSU6JRWK=
SK-MEL-2 MkCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrZdI9KSzVyPUCuOFY1KM7:TR?= MUnTRW5ITVJ?
HCC1187 M1fHemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTBwNE[3Olgh|ryP NYHsdWdXW0GQR1XS
HCC2218 NXLBT|dOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUi1Ulk6UUN3ME2wMlQ4OjJ5IN88US=> M4\xZ3NCVkeHUh?=
NCI-H187 NUm4e4YyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPvTWM2OD1yLkS3PFQh|ryP M2[zVnNCVkeHUh?=
DB MkfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmP0TWM2OD1yLkWwNFU2KM7:TR?= NEC0OndUSU6JRWK=
NCI-H69 NHH0eldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwNUCyOFch|ryP M2KwbXNCVkeHUh?=
NCI-H1694 NXf4UW9rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTuV4FmUUN3ME2wMlUxPjl5IN88US=> NGCwZmlUSU6JRWK=
CA46 M1K5U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXQTWM2OD1yLkWwPVE4KM7:TR?= NIHVUHdUSU6JRWK=
EHEB MnzOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwNUGxPVMh|ryP MmP3V2FPT0WU
NCCIT MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;TPWNVUUN3ME2wMlU1OzJzIN88US=> MUDTRW5ITVJ?
NCI-H720 NU\RfHFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXr0OY05UUN3ME2wMlU1QTZ{IN88US=> NHziXXNUSU6JRWK=
LU-134-A M4WxeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DoV2lEPTB;MD61OVI6PiEQvF2= NUXiV5RtW0GQR1XS
MC-CAR NXy4V5J3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rZdGlEPTB;MD61OVQ{OSEQvF2= NGTjOpVUSU6JRWK=
NEC8 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlm2TWM2OD1yLkW2NVczKM7:TR?= NV;RVY96W0GQR1XS
NCI-H524 NFv6UJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrYbItKSzVyPUCuOVg4PDhizszN NVmxTnV7W0GQR1XS
NCI-H1963 NYTmcXBLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHXPIVKSzVyPUCuOlI2QCEQvF2= M4nkenNCVkeHUh?=
SU-DHL-1 M{fWXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTBwNkS1NlYh|ryP NWfSdm12W0GQR1XS
NCI-H1522 NIjUR45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fXWWlEPTB;MD62OFg5OyEQvF2= NHHEfYJUSU6JRWK=
NCI-H1155 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH:1bHVKSzVyPUCuOlU{PSEQvF2= M{fXbXNCVkeHUh?=
D-263MG MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXP5eVV7UUN3ME2wMlY3OTBzIN88US=> M1:2cnNCVkeHUh?=
TE-6 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwNkixNFQh|ryP Mn;HV2FPT0WU
NCI-H1417 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPvZmxKSzVyPUCuOlk4OTFizszN NHvvV29USU6JRWK=
NCI-H510A MnHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwN{eyN|Yh|ryP MnXuV2FPT0WU
KARPAS-45 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HxcmlEPTB;MD63PFI{PSEQvF2= MV3TRW5ITVJ?
IST-SL1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTITm9KSzVyPUCuPFU5OjVizszN MVXTRW5ITVJ?
COLO-824 NGns[ZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LaUGlEPTB;MD64O|g{PSEQvF2= NWTKbmpsW0GQR1XS
NCI-H526 NYHib3NwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTBwOUC5OVgh|ryP MlTkV2FPT0WU
NCI-H719 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX76[pprUUN3ME2wMlk3PjV5IN88US=> Mo\iV2FPT0WU
SF539 M1WzSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7QZ41KSzVyPUCuPVg{QTZizszN NW\5OmR7W0GQR1XS
NKM-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjYd4tKSzVyPUCuPVg3PjNizszN MoL5V2FPT0WU
A253 NILKcoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLxWJJKSzVyPUCuPVg5QDVizszN MnjtV2FPT0WU
TE-441-T NIXOWldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHTNGlKSzVyPUGuNFQ{PSEQvF2= NWLycHBnW0GQR1XS
COR-L88 M{TqdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVG2bmluUUN3ME2xMlEyOzV2IN88US=> Mki4V2FPT0WU
CPC-N M3LUU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfmTWM2OD1zLkG1PFg5KM7:TR?= MUfTRW5ITVJ?
NCI-H2107 MoW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTFwMUeyOlEh|ryP NWXRZZhIW0GQR1XS
ECC4 NELVTY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmKwTWM2OD1zLkG4Olk{KM7:TR?= M4XsNXNCVkeHUh?=
NCI-H2141 M{HWTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTFwMUmyPVkh|ryP MnS0V2FPT0WU
NCI-H1770 M1[1N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTFwM{K5Nlgh|ryP MYDTRW5ITVJ?
NCI-SNU-1 NXPQOJZ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nG[GlEPTB;MT6zN|A1KM7:TR?= MnTaV2FPT0WU
LU-165 NH\l[mpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXQU|hKSzVyPUGuOFU1PjdizszN NHvOOpNUSU6JRWK=
Raji MlzLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3iRldKSzVyPUGuOFczPTlizszN M2foenNCVkeHUh?=
EW-24 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTFwNUS2NVkh|ryP M4PGRXNCVkeHUh?=
KP-N-RT-BM-1 Ml3aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTFwNU[1OVEh|ryP M3nRPXNCVkeHUh?=
SK-MEL-1 Mk\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLBR2dSUUN3ME2xMlY1QDd5IN88US=> MYfTRW5ITVJ?
SCLC-21H NVrQT4hoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrnWXh[UUN3ME2xMlY3PjVzIN88US=> NUHrXG17W0GQR1XS
SIMA Mn3jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXZTWM2OD1zLk[4NlM{KM7:TR?= M3XsdXNCVkeHUh?=
NCI-H1304 M4T3Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfKS2VKSzVyPUGuO|A4PjVizszN MoTEV2FPT0WU
REH M3jnVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnGTIVtUUN3ME2xMlcyODd6IN88US=> NWrEWGh1W0GQR1XS
KP-N-YS M1HvN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojlTWM2OD1zLkmzOVUyKM7:TR?= M4PDWHNCVkeHUh?=
DMS-153 M3;xemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LWO2lEPTB;MT65O|U6KM7:TR?= M{DLPHNCVkeHUh?=
NB10 M2HlZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjTTWM2OD1{LkKwPFc5KM7:TR?= MWDTRW5ITVJ?
NCI-H345 MnHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrqTWM2OD1{Lk[xPVA2KM7:TR?= M33EPHNCVkeHUh?=
SK-N-FI M4jRRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3J[2U4UUN3ME2yMlc2OzhzIN88US=> MUPTRW5ITVJ?
NCI-H1092 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTmcFU2UUN3ME2yMlk2Ozl2IN88US=> NXrBNWs3W0GQR1XS
KM-H2 NUm1W|d4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLrdotKSzVyPUOuOlU{QTZizszN NGH3RZZUSU6JRWK=
KG-1 M2PoWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIG2SG1KSzVyPUOuO|E3QDhizszN NEfBR2FUSU6JRWK=
D-283MED NWPQNZV{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1izPWlEPTB;Mz63OVg4KM7:TR?= MkLIV2FPT0WU
LU-65 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTRwMUG0PFUh|ryP NFvHO4NUSU6JRWK=
MSTO-211H NGDGeY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PUXGlEPTB;ND6xPFg6QCEQvF2= MXHTRW5ITVJ?
NCI-H2081 NWKxNlVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1eyT2lEPTB;ND6yPVE4PCEQvF2= NXGzOo1WW0GQR1XS
D-247MG MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLWTVVKSzVyPUSuOFMyQTFizszN NFn5flNUSU6JRWK=
P31-FUJ MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTRwNEWwNVkh|ryP MoHiV2FPT0WU
DMS-79 NFPrVoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrrTWM2OD12LkmzNVg{KM7:TR?= NFPw[|NUSU6JRWK=
KASUMI-1 NHTycXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPsU3JKSzVyPUSuPVc2ODlizszN MY\TRW5ITVJ?
JVM-3 M2jWV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MortTWM2OD13LkK1NFE1KM7:TR?= NVyyTmtDW0GQR1XS
LAN-6 NYOxelQ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrke5Z[UUN3ME21MlUyPzN4IN88US=> MV;TRW5ITVJ?
DJM-1 MmPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4f6[WlEPTB;NT61OlAzQSEQvF2= MkPhV2FPT0WU
JVM-2 NFXGO4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPLRpc1UUN3ME21MlY4ODl{IN88US=> NEfNcZpUSU6JRWK=
U-87-MG MkDFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGK4NHVKSzVyPUWuPFk6PjRizszN Mly0V2FPT0WU
SHP-77 NVvPNmlJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mom5TWM2OD13Lkm0PVI5KM7:TR?= M3HCbXNCVkeHUh?=
RPMI-8866 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnz4TWM2OD14LkK3NFE{KM7:TR?= NYjET4g5W0GQR1XS
ES7 M1z5RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3ryN2lEPTB;Nj6zPVkzPCEQvF2= Mn62V2FPT0WU
WSU-NHL M4Hqe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXZTWM2OD14LkWxOlA6KM7:TR?= MYXTRW5ITVJ?
CAS-1 M2O4ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPyTWM2OD15LkC5O|Q6KM7:TR?= Mle0V2FPT0WU
MHH-NB-11 NYrjWoVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRThwMkOxOVIh|ryP NIrkcXRUSU6JRWK=
ES5 NXW2VY5KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXNTWM2OD17LkWyNlg3KM7:TR?= MkDmV2FPT0WU
HDLM-2 M1vtVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfOTWM2OD17Lkm1PVAzKM7:TR?= NFnQUVBUSU6JRWK=
NCI-H2171 M{LHe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTYRW1KSzVyPUGwMlU6OjdizszN MV\TRW5ITVJ?
LNCaP-Clone-FGC MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTFzLkO3NVgh|ryP NGXEcIJUSU6JRWK=
NCI-H1395 MlPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTF{LkK2PVkh|ryP NWS2ZpA1W0GQR1XS
NCI-H1436 MkHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfCT413UUN3ME2xN{4{OTl3IN88US=> M{To[nNCVkeHUh?=
RCC10RGB NUn0foh5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTF|LkOyNlEh|ryP M{PWcXNCVkeHUh?=
SW684 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXkTWM2OD1zMz65O|k4KM7:TR?= NHO0W5hUSU6JRWK=
NCI-H1650 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rxZWlEPTB;MUWuNFQ1PyEQvF2= M1jqO3NCVkeHUh?=
EW-13 MmPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3TTWM2OD1zNT6yNFIyKM7:TR?= M4fQZ3NCVkeHUh?=
EC-GI-10 NE\1ZmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTF3Lki2OFQh|ryP MVHTRW5ITVJ?
CHP-126 Mn70S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1Sxd2lEPTB;MUeuNVkyQCEQvF2= NWLOUng4W0GQR1XS
NCI-H226 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3STmpKSzVyPUG4MlA1ODNizszN NH;xZoZUSU6JRWK=
NCI-H1838 Mn7IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHVTWM2OD1{MD6xPFQ5KM7:TR?= M36wZ3NCVkeHUh?=
EW-11 MkLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDzTWM2OD1{ND6yO|E5KM7:TR?= MkDaV2FPT0WU
EB2 M3fsdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXyxOm1oUUN3ME2zNU42OzF6IN88US=> NUf3U29[W0GQR1XS
D-502MG MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLrTWM2OD12Mz65NlI6KM7:TR?= NIPGVJJUSU6JRWK=
U-698-M NVvFd3RDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPHRoxsUUN3ME20PE45PjdzIN88US=> MWLTRW5ITVJ?
ES3 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnJV|dKSzVyPUS5MlM5QTNizszN NYTjc49NW0GQR1XS

... Click to View More Cell Line Experimental Data

体内研究 Torin1在20 mg/kg剂量下,在U87MG异种移植模型中是有效的,并且在肿瘤和外周组织中对mTOR下游效应蛋白表现出良好的药效学抑制作用。[2]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[1]
+ 展开

mTORC1和 mTORC2体外激酶试验:

为产生可溶性mTORC1,HEK-293T细胞系,稳定表达N端FLAG标记的Raptor,使用水泡性口炎病毒G-假型病毒MSCV逆转录酶病毒产生。对于mTORC2,产生相似的HeLa细胞,能够稳定表达N端FLAG-标记的Protor-1。两个复合物通过在50 mm HEPES,pH 7.4,10 mm 焦磷酸钠,10 mm β-甘油磷酸钠,100 mm NaCl,2 mm EDTA,0.3% CHAPS中裂解细胞纯化。细胞在4 °C下裂解30分钟,不溶解部分通过以13,000 rpm微量离心10分钟移除。上清液与FLAG-M2单克隆抗体-琼脂糖培育1小时,然后用裂解缓冲液洗涤3次,用包含终浓度0.5 M NaCl的裂解缓冲液洗涤1次。纯化的mTORC1用100 μg/mL 3×FLAG多肽在50 mm HEPES,pH 7.4,100 mm NaCl中洗脱。将洗出液等分收集,储存在-80 °C。纯化底物S6K1 和 Akt1。激酶试验在30 °C,由激酶缓冲液(25 mm HEPES,pH 7.4,50 mm KCl,10 mm MgCl2,500 μm ATP)和150 ng 灭活的S6K1或Akt1底物组成的20 μL终体积混合物中进行。反应通过加入80 μL样品缓冲液停止,并沸煮5分钟。随后,样品通过SDS-PAGE和免疫印迹法分析。
细胞实验:[1]
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  • Cell lines: MEFs
  • Concentrations: ~250 nM
  • Incubation Time: 4天
  • Method: 细胞活性通过CellTiter-Glo发光法细胞活性测定评估。在第0天,细胞以500细胞每孔接种到96孔板,并生长过夜。第1天,细胞用适当的化合物处理,随后在第3-5天分析。对于分析,板在室温下培育60分钟,将50 μL CellTiter-Glo试剂加入每孔中,板在定轨摇床上混合12分钟。发光在标准平板光度计上定量。
    (Only for Reference)
动物实验:[2]
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  • Animal Models: U87MG 异种移植物模型
  • Formulation: Torin1粉末首先以25 mg/mL在100% N-甲基-2-吡咯烷酮中溶解,随后以1:4 与无菌 50% PEG400稀释到5 mg/mL的终浓度
  • Dosages: 20 mg/kg
  • Administration: 腹腔注射给药,每天一次
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 2 mg/mL (3.29 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
20% NMP+50% PEG 400
5mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 607.62
化学式

C35H28F3N5O2

CAS号 1222998-36-8
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    How to re-constitute the inhibitor for i.p. administration?

  • 回答:

    S2827 Torin 1 can be dissolved in 5% DMSO/30% PEG 300/ddH2O at 0.25 mg/ml clearly, and in 10% DMSO/corn oil at 0.5 mg/ml, it is also a clear solution.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID