Torin 1

目录号:S2827

Torin 1 Chemical Structure

Molecular Weight(MW): 607.62

Torin 1是一种有效的mTORC1/2抑制剂,在无细胞试验中IC50为2 nM/10 nM;作用于mTOR比作用于PI3K选择性高1000倍。

规格 价格 库存 购买数量  
RMB 1419.84 现货
RMB 3019.04 现货
RMB 5492.28 现货
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客户使用该产品的5个实验数据:

  • Huh-7.5 cells were treated with increasing concentration of Torin 1, a known autophagy inducer, and the autophagy response was assessed by measuring LC3II and p62 levels.

    Am J Pathol 2014 184(1), 214-29. Torin 1 purchased from Selleck.

    Flag-tagged SENP3 was immunoprecipitated from HeLa cells and used for in vitro phosphorylation assay with [32P]ATP with either the mock-treated or Torin1-treated mTOR/Raptor/MLST8 complex. (Upper) The samples then were subjected to SDS-PAGE, followed by autoradiography. mTOR autophosphorylation is indicated by an asterisk. (Lower) Immunopurified SENP3 was monitored by Western blotting with anti-Flag antibody.

    Mol Cell Biol 2014 34(24), 4474-84. Torin 1 purchased from Selleck.

  • Exp Cell Res, 2018, 363(1):84-94. Torin 1 purchased from Selleck.

    Representative Western blots showing LC3 in PP242 (PP) or Torin1 (Tor) treated HepG2 cells. HepG2 cells were treated with 10 uM PP242 or 0.1 uM Torin1 for 24 h.

    Biochem Biophys Res Commun 2014 10.1016/j.bbrc.2014.05.047. Torin 1 purchased from Selleck.

  • Bone marrow derived macrophages were pre-treated with 10nM Torin 1 for 1h prior to LPS treatment (100 ng/ml). TNF-a production was analyzed 24h later.

    Lim Hsiu Kim, Lina from National University of Singapore. Torin 1 purchased from Selleck.

产品安全说明书

mTOR抑制剂选择性比较

生物活性

产品描述 Torin 1是一种有效的mTORC1/2抑制剂,在无细胞试验中IC50为2 nM/10 nM;作用于mTOR比作用于PI3K选择性高1000倍。
靶点
mTORC1 [1]
(Cell-free assay)
mTOR [2]
(Cell-free assay)
DNA-PK [2]
(Cell-free assay)
mTORC2 [1]
(Cell-free assay)
p110γ [2]
(Cell-free assay)
2 nM 4.32 nM 6.34 nM 10 nM 171 nM
体外研究

Torin1在2和10 nM浓度下分别抑制mTORC1 和mTORC2底物的磷酸化。此外,Torin1对mTOR比对PI3K (EC50 = 1800 nM)的选择性高1000倍,比对450种其它蛋白激酶的结合选择性高100倍。[1] [2] Torin1通过耐rapamycin机制引起细胞周期阻滞,并且其不依赖于mTORC2。Torin1比rapamycin更完全地干扰mTORC1依赖表现型。Cap依赖性翻译需要mTORC1耐Rapamycin的功能。[1]在近期的一项研究中,据报道Torin1通过活化人内分泌细胞系BON 中MEK/ERK/c-Jun通路,能够增加神经降压素分泌和基因表达。[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
ETK-1 MmHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjyTWM2OD1yLkCwNFMxPiEQvF2= NWTZXWRuW0GQR1XS
OCUB-M NH;zb4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn35TWM2OD1yLkCwNVk1KM7:TR?= M1PaWHNCVkeHUh?=
DOHH-2 NV34fHV6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HZcGlEPTB;MD6wNFIzPSEQvF2= MWPTRW5ITVJ?
NOS-1 NHSxNVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzBTWM2OD1yLkCwNlQzKM7:TR?= MmLmV2FPT0WU
L-363 NWXsWWl1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PRT2lEPTB;MD6wNFI5PCEQvF2= MYnTRW5ITVJ?
RL95-2 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rFUGlEPTB;MD6wNFMzKM7:TR?= M37heHNCVkeHUh?=
BL-70 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTVfnVKSzVyPUCuNFA{OzdizszN NVfNSYhsW0GQR1XS
TGBC1TKB M13ZdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzQVog5UUN3ME2wMlAxOzd7IN88US=> MYHTRW5ITVJ?
697 MmfFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXiXmNKSzVyPUCuNFA3OzRizszN MYHTRW5ITVJ?
RPMI-8226 MlPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnRTJhKSzVyPUCuNFA3PTFizszN NGDqdVZUSU6JRWK=
BL-41 NVHHZ281T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;EV5Y1UUN3ME2wMlAxPjl4IN88US=> MVjTRW5ITVJ?
MRK-nu-1 NIjUWW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PKeGlEPTB;MD6wNFcxPyEQvF2= M{LOV3NCVkeHUh?=
EW-1 MoSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDVelM2UUN3ME2wMlAxPzR7IN88US=> MVHTRW5ITVJ?
EVSA-T MnfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnQNmQzUUN3ME2wMlAxQDl{IN88US=> MojZV2FPT0WU
HUTU-80 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTBwMEC5Nlkh|ryP M{X5NnNCVkeHUh?=
VA-ES-BJ NVi2dI1lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PrbGlEPTB;MD6wNFk5PCEQvF2= MmPrV2FPT0WU
GCIY NGD3ZYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFK4fHhKSzVyPUCuNFExODdizszN MX\TRW5ITVJ?
ES6 NUDzdVJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2q4N2lEPTB;MD6wNVA5OyEQvF2= MVLTRW5ITVJ?
NALM-6 NVvET|RyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fIZmlEPTB;MD6wNVExOiEQvF2= MUjTRW5ITVJ?
LB996-RCC MlrxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnK1TWM2OD1yLkCxNVM4KM7:TR?= M{HBUnNCVkeHUh?=
EW-16 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrQTm9KSzVyPUCuNFEyQTJizszN MnS0V2FPT0WU
KALS-1 MoCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF64UXdKSzVyPUCuNFEyQThizszN MVfTRW5ITVJ?
OPM-2 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;JZmNtUUN3ME2wMlAyOjlizszN NWnDdm4{W0GQR1XS
KU812 M3PhXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwMEGyPVYh|ryP NELae|NUSU6JRWK=
A4-Fuk MnjrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTBwMEGzNVkh|ryP M37FcXNCVkeHUh?=
KGN NYDiU|BiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTBwMEGzOVkh|ryP NFruVY1USU6JRWK=
KS-1 M3PtZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVWwblN2UUN3ME2wMlAyOzl{IN88US=> M{O2N3NCVkeHUh?=
no-11 NHy4dnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlywTWM2OD1yLkCxN|k2KM7:TR?= M3;MeHNCVkeHUh?=
PSN1 NY\VcGlHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2f5cWlEPTB;MD6wNVQxQSEQvF2= NGj2e|JUSU6JRWK=
SK-LMS-1 NIO2XnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXVTWM2OD1yLkCxOFE{KM7:TR?= MlvFV2FPT0WU
LS-411N NFrRRlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LKPGlEPTB;MD6wNVQ{QSEQvF2= NXjxSYxnW0GQR1XS
HT-144 NGjm[4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHftfJZKSzVyPUCuNFE1PTFizszN M4LyNHNCVkeHUh?=
ACN NEfqb2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLkTWM2OD1yLkCxOUDPxE1? NWXsWnA2W0GQR1XS
RKO NVrXW|FKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwMEG1N|Mh|ryP MYHTRW5ITVJ?
CMK M{DwfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfRTYR{UUN3ME2wMlAyPTR|IN88US=> NHvld5hUSU6JRWK=
GB-1 NYe5[pRyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTBwMEG1OVMh|ryP M4XX[XNCVkeHUh?=
KE-37 NWnFO41IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml:3TWM2OD1yLkCxOVc{KM7:TR?= NGP0PXlUSU6JRWK=
no-10 NGfsco9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTBwMEG1PFQh|ryP NVXCWohEW0GQR1XS
MOLT-16 NWO5PWRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTBwMEG2NlIh|ryP MmnTV2FPT0WU
HEL NVzuXnlwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjGTWM2OD1yLkCxOlQh|ryP NYjmO|J{W0GQR1XS
NCI-H1355 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTBwMEG2OFYh|ryP M33zUHNCVkeHUh?=
IST-MEL1 MnPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7N[|FKSzVyPUCuNFE4PzRizszN NF3UfWZUSU6JRWK=
MHH-PREB-1 NVfRT4tzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwMEG4NVgh|ryP M3PsNHNCVkeHUh?=
ES8 M4rMb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4WxZ2lEPTB;MD6wNVg1PCEQvF2= MXvTRW5ITVJ?
LC-2-ad NUjLfW94T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGi4[JpKSzVyPUCuNFIyOzdizszN NF7ab|VUSU6JRWK=
LAMA-84 M1;ob2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnT2TWM2OD1yLkCyNVY4KM7:TR?= MUDTRW5ITVJ?
BV-173 NGq5bHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwMEKyNFMh|ryP Ml3YV2FPT0WU
SW872 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELscHRKSzVyPUCuNFIzPDdizszN NVvqO|VTW0GQR1XS
SK-UT-1 M4n3eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TGVWlEPTB;MD6wNlI3OSEQvF2= M{fjfnNCVkeHUh?=
OS-RC-2 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\N[GlEPTB;MD6wNlMzOyEQvF2= M{DqeXNCVkeHUh?=
NCI-H747 M4e5d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXWbVJ3UUN3ME2wMlAzOzNizszN M4\QZXNCVkeHUh?=
MZ2-MEL M1LP[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzU[3lKSzVyPUCuNFI{OzdizszN MoHSV2FPT0WU
TE-11 NH\TbopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnYVlNiUUN3ME2wMlAzOzd{IN88US=> MUjTRW5ITVJ?
KURAMOCHI M3PvcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4H2cWlEPTB;MD6wNlQyPCEQvF2= MXLTRW5ITVJ?
HD-MY-Z M373O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHYW4tOUUN3ME2wMlAzPDJ4IN88US=> NXLJSZJwW0GQR1XS
GI-1 Mmr0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDHTnZKSzVyPUCuNFI1PjlizszN M2mwOnNCVkeHUh?=
LB1047-RCC NGXaOXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTBwMEK0PFgh|ryP MVnTRW5ITVJ?
TE-12 MmL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DmZ2lEPTB;MD6wNlU2KM7:TR?= M2HS[nNCVkeHUh?=
MZ7-mel NX\JPHU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\rTWM2OD1yLkCyOlA6KM7:TR?= MUjTRW5ITVJ?
MMAC-SF M{\SSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTBwMEK2N|Mh|ryP M4noR3NCVkeHUh?=
A101D MojVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nlSmlEPTB;MD6wNlY2KM7:TR?= M2fKWnNCVkeHUh?=
GR-ST MmPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXi5[ItrUUN3ME2wMlAzPjV3IN88US=> NUntZZh3W0GQR1XS
MC116 MnOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;xTWM2OD1yLkCyOlgh|ryP NWLObndCW0GQR1XS
Ramos-2G6-4C10 Mn\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4SwdWlEPTB;MD6wNlc2KM7:TR?= M2exUXNCVkeHUh?=
ATN-1 MkGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwMEK3PFkh|ryP NUDuXmhKW0GQR1XS
MFH-ino M2LJTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzUNnJxUUN3ME2wMlAzQDF{IN88US=> NFHtNm9USU6JRWK=
DEL NFXjRnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPzTWM2OD1yLkCyPFE2KM7:TR?= MnjhV2FPT0WU
OCI-AML2 MkLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljMTWM2OD1yLkCyPFcyKM7:TR?= NHzYSW9USU6JRWK=
LXF-289 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkP6TWM2OD1yLkCyPFczKM7:TR?= NVHFcmFTW0GQR1XS
IA-LM MknCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fQVmlEPTB;MD6wNlkyPyEQvF2= NIK3WWNUSU6JRWK=
EoL-1-cell M3frd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1KxWWlEPTB;MD6wNlk6PiEQvF2= MY\TRW5ITVJ?
OVCAR-4 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3P5fWlEPTB;MD6wN|A6PCEQvF2= M1\YdXNCVkeHUh?=
ES1 M1mwRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TlZmlEPTB;MD6wN|A6PyEQvF2= MnfEV2FPT0WU
CESS NXXrVGZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYX2bGg2UUN3ME2wMlA{ODl7IN88US=> M3;VWnNCVkeHUh?=
GAK MnjMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGW5co9KSzVyPUCuNFMyQDZizszN NXS3VGNlW0GQR1XS
NTERA-S-cl-D1 NYLycIdvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXaWZV3UUN3ME2wMlA{OjJ4IN88US=> Ml33V2FPT0WU
TE-10 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwMEOzNVEh|ryP M2n2PHNCVkeHUh?=
CCRF-CEM NXu0RWg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHWSGsxUUN3ME2wMlA{OzdzIN88US=> MkizV2FPT0WU
NMC-G1 Mn7aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3H0VmlEPTB;MD6wN|Q1QCEQvF2= M1P6WnNCVkeHUh?=
HOP-62 Mny5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUn2cWJXUUN3ME2wMlA{PTV4IN88US=> NYDydZR7W0GQR1XS
SH-4 M3jtfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPob3FKSzVyPUCuNFM2QDJizszN MUnTRW5ITVJ?
NCI-H1648 M4XVNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjZRnFKSzVyPUCuNFM3OjJizszN NISwe|ZUSU6JRWK=
EB-3 NIOzRmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTBwMEO2OFMh|ryP NYG2[Gh7W0GQR1XS
BB65-RCC NFuxVpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIWzOpdKSzVyPUCuNFM3QTFizszN MlT4V2FPT0WU
BE-13 NFP4U3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fkNWlEPTB;MD6wN|c2QSEQvF2= NU\NPY9HW0GQR1XS
CP67-MEL MmflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTBwMEO3OVkh|ryP MYHTRW5ITVJ?
SW954 M3;wcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUj3UYFMUUN3ME2wMlA{PzlizszN MYHTRW5ITVJ?
TE-5 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\sSWJKSzVyPUCuNFM5PTRizszN MnXUV2FPT0WU
HCE-4 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnJcJFKSzVyPUCuNFM5PTVizszN M{XEOHNCVkeHUh?=
LC-1F MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7OTWM2OD1yLkCzPVg6KM7:TR?= NEO4OJhUSU6JRWK=
TK10 NGC4dpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDxU4JKUUN3ME2wMlA1ODF7IN88US=> Ml\wV2FPT0WU
SJSA-1 NF76NlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fWNmlEPTB;MD6wOFE5QCEQvF2= NWnWeYtGW0GQR1XS
Daudi NYXSXXJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2G1TGlEPTB;MD6wOFIzPSEQvF2= NWX2N|VuW0GQR1XS
SW982 M1H6cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTBwMESyOFYh|ryP NIHpU4ZUSU6JRWK=
SF126 Ml;NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDRTWM2OD1yLkC0N|YyKM7:TR?= Mo\sV2FPT0WU
TE-15 NEPkbIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHu5b5JKSzVyPUCuNFQ1OzVizszN MUfTRW5ITVJ?
COLO-684 NXzrbZhMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkf0TWM2OD1yLkC0OVYyKM7:TR?= MVfTRW5ITVJ?
8-MG-BA MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTBwMES2Nlkh|ryP NH\ETYhUSU6JRWK=
NB13 MnjxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfGTWM2OD1yLkC0O|c3KM7:TR?= M17vNXNCVkeHUh?=
HCC1599 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPpTWM2OD1yLkC0PFc6KM7:TR?= MYPTRW5ITVJ?
SK-PN-DW NXLqPIVXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGe3UWxKSzVyPUCuNFQ6PDlizszN MljvV2FPT0WU
ALL-PO NEHLd3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1[ybWlEPTB;MD6wOFk2PiEQvF2= NUfwfGlsW0GQR1XS
NB6 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTBwMEWyO|Eh|ryP MYfTRW5ITVJ?
IST-SL2 NWDDbYlCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDBNZNQUUN3ME2wMlA2OzZ{IN88US=> MojLV2FPT0WU
BB30-HNC Mly3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfxXYtKSzVyPUCuNFU4OyEQvF2= Ml7GV2FPT0WU
SW962 NELzSI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPCTWM2OD1yLkC1O|Y{KM7:TR?= MlvKV2FPT0WU
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TGW NFX3d5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXG0RpcyUUN3ME2wMlM4PDV|IN88US=> MnvIV2FPT0WU
SNU-C1 NWO5WmgxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrXc|ZKSzVyPUCuN|gzOTVizszN NXW1WndvW0GQR1XS
LS-513 NIrqO5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\iUVM4UUN3ME2wMlM6ODdzIN88US=> MoLqV2FPT0WU
NOMO-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2n5SWlEPTB;MD6zPVk4OSEQvF2= NGPs[lZUSU6JRWK=
MS-1 M1zwVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\ScmxKSzVyPUCuOFAyPzdizszN NIGwPXVUSU6JRWK=
EKVX MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\4TGlEPTB;MD60OFQ3OSEQvF2= NWrkO3B2W0GQR1XS
SK-MEL-2 M1PIS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrJWIFzUUN3ME2wMlQ3PCEQvF2= NGPoSnJUSU6JRWK=
HCC1187 NIrrcmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTBwNE[3Olgh|ryP MVvTRW5ITVJ?
HCC2218 NVr6WJd5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwNEeyNlch|ryP MnjHV2FPT0WU
NCI-H187 NWXJPXlsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rad2lEPTB;MD60O|g1KM7:TR?= NIDBS5pUSU6JRWK=
DB NGDF[oNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTBwNUCwOVUh|ryP NGrzTnJUSU6JRWK=
NCI-H69 M1jY[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwNUCyOFch|ryP M{TWZnNCVkeHUh?=
NCI-H1694 M1y5N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrxcFBKSzVyPUCuOVA3QTdizszN M{jFU3NCVkeHUh?=
CA46 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3CTWM2OD1yLkWwPVE4KM7:TR?= NFHFS5JUSU6JRWK=
EHEB MnvuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrLTIdKSzVyPUCuOVEyQTNizszN NXvSZlF7W0GQR1XS
NCCIT M{\3fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PiOGlEPTB;MD61OFMzOSEQvF2= MlPKV2FPT0WU
NCI-H720 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;QbplKSzVyPUCuOVQ6PjJizszN MYnTRW5ITVJ?
LU-134-A NILDeI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFv1cmdKSzVyPUCuOVUzQTZizszN Mn\PV2FPT0WU
MC-CAR MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\3TWM2OD1yLkW1OFMyKM7:TR?= MnrQV2FPT0WU
NEC8 MkPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYi1NIJUUUN3ME2wMlU3OTd{IN88US=> NITlV4JUSU6JRWK=
NCI-H524 NX;ySYZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwNUi3OFgh|ryP M3vRZ3NCVkeHUh?=
NCI-H1963 MlvVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnjS29KSzVyPUCuOlI2QCEQvF2= M1TuOnNCVkeHUh?=
SU-DHL-1 NGDBW|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTBwNkS1NlYh|ryP NGHNfWJUSU6JRWK=
NCI-H1522 NH3EO2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwNkS4PFMh|ryP Ml7YV2FPT0WU
NCI-H1155 MnexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nEPGlEPTB;MD62OVM2KM7:TR?= MYDTRW5ITVJ?
D-263MG NF\2PIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwNk[xNFEh|ryP MWLTRW5ITVJ?
TE-6 NGrvdYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPJTGwxUUN3ME2wMlY5OTB2IN88US=> NFvI[FVUSU6JRWK=
NCI-H1417 MmfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rNTWlEPTB;MD62PVcyOSEQvF2= M4LGZ3NCVkeHUh?=
NCI-H510A NYrEVWdGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHOwPIdKSzVyPUCuO|czOzZizszN M4nFZ3NCVkeHUh?=
KARPAS-45 NF7TdIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHGTWM2OD1yLke4NlM2KM7:TR?= MkPCV2FPT0WU
IST-SL1 M2jVPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LteGlEPTB;MD64OVgzPSEQvF2= NFXKVHdUSU6JRWK=
COLO-824 NF25fm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHRO5BKSzVyPUCuPFc5OzVizszN MlXJV2FPT0WU
NCI-H526 M4\6fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTaTWM2OD1yLkmwPVU5KM7:TR?= M{fkVXNCVkeHUh?=
NCI-H719 NF;FbmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1[zOWlEPTB;MD65OlY2PyEQvF2= NFHENZpUSU6JRWK=
SF539 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWP6dolxUUN3ME2wMlk5Ozl4IN88US=> MVnTRW5ITVJ?
NKM-1 NGK1cpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzMdnlOUUN3ME2wMlk5PjZ|IN88US=> MnXHV2FPT0WU
A253 NULqPHhST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXyTWM2OD1yLkm4PFg2KM7:TR?= NYrRfFN4W0GQR1XS
TE-441-T M3v2PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTFwMESzOUDPxE1? M3PFNXNCVkeHUh?=
COR-L88 M4Lwc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFe0XJhKSzVyPUGuNVE{PTRizszN NUX2PI5lW0GQR1XS
CPC-N M2X6cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M375dGlEPTB;MT6xOVg5QCEQvF2= M{LtcnNCVkeHUh?=
NCI-H2107 M3nvdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULyPGpoUUN3ME2xMlE4OjZzIN88US=> MV3TRW5ITVJ?
ECC4 NGO0d3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MluyTWM2OD1zLkG4Olk{KM7:TR?= MXTTRW5ITVJ?
NCI-H2141 NVT1fZZ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXqV5d5UUN3ME2xMlE6Ojl7IN88US=> NUnhfXg5W0GQR1XS
NCI-H1770 NH[2cmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVr3fnd2UUN3ME2xMlMzQTJ6IN88US=> M1XYd3NCVkeHUh?=
NCI-SNU-1 NX;FbXZ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTFwM{OwOEDPxE1? M4mzNnNCVkeHUh?=
LU-165 M1[wdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jrTWlEPTB;MT60OVQ3PyEQvF2= MVTTRW5ITVJ?
Raji MmW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTFwNEeyOVkh|ryP MXTTRW5ITVJ?
EW-24 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTFwNUS2NVkh|ryP MYrTRW5ITVJ?
KP-N-RT-BM-1 NXjqW29mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILMZXBKSzVyPUGuOVY2PTFizszN NVL0TFRHW0GQR1XS
SK-MEL-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3Hsb2lEPTB;MT62OFg4PyEQvF2= MmTYV2FPT0WU
SCLC-21H NICxdoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjlOoVHUUN3ME2xMlY3PjVzIN88US=> NGKzT5lUSU6JRWK=
SIMA M1;MOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTFwNkiyN|Mh|ryP M4\IT3NCVkeHUh?=
NCI-H1304 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\veFlKSzVyPUGuO|A4PjVizszN NYj2XVZNW0GQR1XS
REH M3;iXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjPfYtTUUN3ME2xMlcyODd6IN88US=> MYrTRW5ITVJ?
KP-N-YS NHz0VVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTFwOUO1OVEh|ryP M3r5XXNCVkeHUh?=
DMS-153 M2P0OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4S2T2lEPTB;MT65O|U6KM7:TR?= MoLaV2FPT0WU
NB10 NF;uVVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfmUmRnUUN3ME2yMlIxQDd6IN88US=> M4Xjc3NCVkeHUh?=
NCI-H345 NVO2ZlVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fnWmlEPTB;Mj62NVkxPSEQvF2= MUPTRW5ITVJ?
SK-N-FI M4jXemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvidXZKSzVyPUKuO|U{QDFizszN MW\TRW5ITVJ?
NCI-H1092 MljnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2SxRmlEPTB;Mj65OVM6PCEQvF2= NYO2SotsW0GQR1XS
KM-H2 NYXQbHZ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTNwNkWzPVYh|ryP M3vmU3NCVkeHUh?=
KG-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHaTotZUUN3ME2zMlcyPjh6IN88US=> NVTmOXdTW0GQR1XS
D-283MED NEC5RlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTNwN{W4O{DPxE1? NUjYc2hjW0GQR1XS
LU-65 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fPR2lEPTB;ND6xNVQ5PSEQvF2= NISwR|VUSU6JRWK=
MSTO-211H MmfpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nCPWlEPTB;ND6xPFg6QCEQvF2= NEHXNnpUSU6JRWK=
NCI-H2081 M1O0SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTRwMkmxO|Qh|ryP NVP3WGRVW0GQR1XS
D-247MG NIrqSnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmT4TWM2OD12LkSzNVkyKM7:TR?= MnnHV2FPT0WU
P31-FUJ NGLyRpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfoVVlZUUN3ME20MlQ2ODF7IN88US=> MonoV2FPT0WU
DMS-79 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEX0ZY9KSzVyPUSuPVMyQDNizszN NVXJZo5mW0GQR1XS
KASUMI-1 M1fESWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTHVopbUUN3ME20Mlk4PTB7IN88US=> MWXTRW5ITVJ?
JVM-3 NIPjTWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnhTWM2OD13LkK1NFE1KM7:TR?= NXrzPVJbW0GQR1XS
LAN-6 NFrwSnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorxTWM2OD13LkWxO|M3KM7:TR?= Mn;4V2FPT0WU
DJM-1 NGm5cmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XveWlEPTB;NT61OlAzQSEQvF2= NGC1bZpUSU6JRWK=
JVM-2 NYTZNZhGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTVwNkewPVIh|ryP NHrWR3ZUSU6JRWK=
U-87-MG Ml;lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTVwOEm5OlQh|ryP M4q4dnNCVkeHUh?=
SHP-77 NV7YfJhFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfPNpVRUUN3ME21Mlk1QTJ6IN88US=> M{PweHNCVkeHUh?=
RPMI-8866 NVLa[IN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDqTotMUUN3ME22MlI4ODF|IN88US=> MWrTRW5ITVJ?
ES7 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTZwM{m5NlQh|ryP M4PXfHNCVkeHUh?=
WSU-NHL MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTRTWM2OD14LkWxOlA6KM7:TR?= MX;TRW5ITVJ?
CAS-1 MlzqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVizenhyUUN3ME23MlA6PzR7IN88US=> M3zVU3NCVkeHUh?=
MHH-NB-11 NWjrdI1RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkftTWM2OD16LkKzNVUzKM7:TR?= MX;TRW5ITVJ?
ES5 M1HD[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPR[YljUUN3ME25MlUzOjh4IN88US=> MmLpV2FPT0WU
HDLM-2 NGO4TJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXVTWM2OD17Lkm1PVAzKM7:TR?= NWSxOW1jW0GQR1XS
NCI-H2171 Mm\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfnfIZKUUN3ME2xNE42QTJ5IN88US=> NWPjfVVVW0GQR1XS
LNCaP-Clone-FGC M2XEfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmWxTWM2OD1zMT6zO|E5KM7:TR?= MmfmV2FPT0WU
NCI-H1395 NVLWVoFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;lVFlKSzVyPUGyMlI3QTlizszN M3XqdXNCVkeHUh?=
NCI-H1436 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rJe2lEPTB;MUOuN|E6PSEQvF2= M4XPb3NCVkeHUh?=
RCC10RGB NWHNOnczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFG2SW5KSzVyPUGzMlMzOjFizszN M{mzNHNCVkeHUh?=
SW684 NUnQWGhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rhZ2lEPTB;MUOuPVc6PyEQvF2= MV7TRW5ITVJ?
NCI-H1650 MmP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\5UmlEPTB;MUWuNFQ1PyEQvF2= NVOyeY5MW0GQR1XS
EW-13 NVnTTYV3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXe4PYRyUUN3ME2xOU4zODJzIN88US=> M4[5SXNCVkeHUh?=
EC-GI-10 MkfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTnXJMxUUN3ME2xOU45PjR2IN88US=> MlXwV2FPT0WU
CHP-126 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTF5LkG5NVgh|ryP NVLUepBDW0GQR1XS
NCI-H226 M12zW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlOxTWM2OD1zOD6wOFA{KM7:TR?= NFLOUJdUSU6JRWK=
NCI-H1838 NUXXT|hnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIm4SGZKSzVyPUKwMlE5PDhizszN NIrw[5lUSU6JRWK=
EW-11 NXHx[XR6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVm4e5RWUUN3ME2yOE4zPzF6IN88US=> NGjFcG1USU6JRWK=
EB2 NF[5OlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHNV2pKSzVyPUOxMlU{OThizszN MXfTRW5ITVJ?
D-502MG MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkT0TWM2OD12Mz65NlI6KM7:TR?= Mm\qV2FPT0WU
U-698-M Mlz3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4[zOmlEPTB;NEiuPFY4OSEQvF2= MWXTRW5ITVJ?
ES3 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoT4TWM2OD12OT6zPFk{KM7:TR?= NGW0[VlUSU6JRWK=

... Click to View More Cell Line Experimental Data

体内研究 Torin1在20 mg/kg剂量下,在U87MG异种移植模型中是有效的,并且在肿瘤和外周组织中对mTOR下游效应蛋白表现出良好的药效学抑制作用。[2]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[1]
+ 展开

mTORC1和 mTORC2体外激酶试验:

为产生可溶性mTORC1,HEK-293T细胞系,稳定表达N端FLAG标记的Raptor,使用水泡性口炎病毒G-假型病毒MSCV逆转录酶病毒产生。对于mTORC2,产生相似的HeLa细胞,能够稳定表达N端FLAG-标记的Protor-1。两个复合物通过在50 mm HEPES,pH 7.4,10 mm 焦磷酸钠,10 mm β-甘油磷酸钠,100 mm NaCl,2 mm EDTA,0.3% CHAPS中裂解细胞纯化。细胞在4 °C下裂解30分钟,不溶解部分通过以13,000 rpm微量离心10分钟移除。上清液与FLAG-M2单克隆抗体-琼脂糖培育1小时,然后用裂解缓冲液洗涤3次,用包含终浓度0.5 M NaCl的裂解缓冲液洗涤1次。纯化的mTORC1用100 μg/mL 3×FLAG多肽在50 mm HEPES,pH 7.4,100 mm NaCl中洗脱。将洗出液等分收集,储存在-80 °C。纯化底物S6K1 和 Akt1。激酶试验在30 °C,由激酶缓冲液(25 mm HEPES,pH 7.4,50 mm KCl,10 mm MgCl2,500 μm ATP)和150 ng 灭活的S6K1或Akt1底物组成的20 μL终体积混合物中进行。反应通过加入80 μL样品缓冲液停止,并沸煮5分钟。随后,样品通过SDS-PAGE和免疫印迹法分析。
细胞实验:[1]
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  • Cell lines: MEFs
  • Concentrations: ~250 nM
  • Incubation Time: 4天
  • Method: 细胞活性通过CellTiter-Glo发光法细胞活性测定评估。在第0天,细胞以500细胞每孔接种到96孔板,并生长过夜。第1天,细胞用适当的化合物处理,随后在第3-5天分析。对于分析,板在室温下培育60分钟,将50 μL CellTiter-Glo试剂加入每孔中,板在定轨摇床上混合12分钟。发光在标准平板光度计上定量。
    (Only for Reference)
动物实验:[2]
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  • Animal Models: U87MG 异种移植物模型
  • Formulation: Torin1粉末首先以25 mg/mL在100% N-甲基-2-吡咯烷酮中溶解,随后以1:4 与无菌 50% PEG400稀释到5 mg/mL的终浓度
  • Dosages: 20 mg/kg
  • Administration: 腹腔注射给药,每天一次
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 2 mg/mL (3.29 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
20% NMP+50% PEG 400
5mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 607.62
化学式

C35H28F3N5O2

CAS号 1222998-36-8
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    How to re-constitute the inhibitor for i.p. administration?

  • 回答:

    S2827 Torin 1 can be dissolved in 5% DMSO/30% PEG 300/ddH2O at 0.25 mg/ml clearly, and in 10% DMSO/corn oil at 0.5 mg/ml, it is also a clear solution.

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mTOR Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID