Afatinib (BIBW2992)

目录号:S1011

Afatinib (BIBW2992) Chemical Structure

Molecular Weight(MW): 485.94

Afatinib (BIBW2992)不可逆地抑制EGFR/ErbB,包括EGFR(wt)EGFR(L858R),EGFR(L858R/T790M),ErbB2(HER2)和ErbB4(HER4),在无细胞试验中IC50分别为0.5 nM,0.4 nM,10 nM,14 nM和1 nM。

规格 价格 库存 购买数量  
RMB 1964.25 现货
RMB 977.68 现货
RMB 1724.11 现货
RMB 4652.69 现货
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客户购买Selleck的此次产品后发表的文献37篇:

客户使用该产品的4个实验数据:

  • Cytoxicity of irreversible EGFR TKIS and ethacrynic acid on breast cells lines. A, Mean IC50 value of Afatinib.

    Oncotarget, 2016, 7(36):58038-58050. Afatinib (BIBW2992) purchased from Selleck.

    Inhibition of signaling pathway activation in lung tumor cell lines by kinase inhibitors. Lung tumor cells were cultured in 10% FBS until reaching ∼80% confluence and then the cells were starved in serum-free medium for overnight, followed by 4-hour treatment with the inhibitors. Cell lysates were then prepared and used for determination of the pathway activation signals by the CEER assay.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

  • Inhibition of anchorage-independent growth of lung tumor cell lines by selected inhibitors. Each selected cell line was treated with the indicated inhibitor at 0.1 μM and 1 μM concentrations for two weeks and cell colony size formation was scored under the Nikon inverted-phase microscope.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

    After starved in serum-free medium for 24h, Breast cancer cells incubated with the indicated concentrations of BIBW2992 for 3h,followed by 15-minute stimolation of 100ng/ml EGF

    Dr. Zhang of Tianjin Medical University. Afatinib (BIBW2992) purchased from Selleck.

产品安全说明书

EGFR抑制剂选择性比较

生物活性

产品描述 Afatinib (BIBW2992)不可逆地抑制EGFR/ErbB,包括EGFR(wt)EGFR(L858R),EGFR(L858R/T790M),ErbB2(HER2)和ErbB4(HER4),在无细胞试验中IC50分别为0.5 nM,0.4 nM,10 nM,14 nM和1 nM。
靶点
EGFR (L858R) [1]
(Cell-free assay)
EGFR (wt) [1]
(Cell-free assay)
ErbB4 [2]
(Cell-free assay)
EGFR (L858R/T790M) [1]
(Cell-free assay)
HER2 [1]
(Cell-free assay)
0.4 nM 0.5 nM 1 nM 10 nM 14 nM
体外研究

BIBW2992不可逆地抑制EGFR/HER2,在体外作用于野生型EGFR ,L858R突变型EGFR, L858R/T790M 双突变型EGFR,及HER2时IC50分别为0.5, 0.4, 10, 14 nM。在体外实验中,BIBW2992不管作用于野生型EGFR/HER2还是突变型EGFR/HER2都显示出强大的活力,与gefitinib作用于L858R突变型EGFR的活力差不多,但是要比gefitinib 作用于L858R-T790M双突变型EGFR的活力大100倍。在体外,BIBW2992有效抑制所有实验类型细胞的EGFR/HER磷酸化作用。比如人类扁平上皮癌A431细胞系表达的野生型EGFR, 鼠类NIH-3T3细胞转染的野生型HER2 , 以及乳腺癌BT-474细胞系和胃癌NCI-N87细胞系表达的内源性HER2。[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HDLM-2 NV\u[mZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTBwMEC1O|Ih|ryP MnfJV2FPT0WU
KASUMI-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTs[oppUUN3ME2wMlAxQTFzIN88US=> NID0fJVUSU6JRWK=
HCC2218 NGr5dVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTBwMEC5PFch|ryP NY\RTZJSW0GQR1XS
KARPAS-45 NVHHdZJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fuRmlEPTB;MD6wNVY4OSEQvF2= MofwV2FPT0WU
HSC-4 NXnIN|R[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTBwMEG3OFgh|ryP NGTBO4dUSU6JRWK=
CHL-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvqTWM2OD1yLkCxPFM6KM7:TR?= NUfw[WRVW0GQR1XS
KY821 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTBwMEKwOkDPxE1? M2X6O3NCVkeHUh?=
NCI-N87 M37HXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;ETFZKSzVyPUCuNFI4PzNizszN NXfQ[YNnW0GQR1XS
DOK NVzBd5Y1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwMEOxPVQh|ryP NX3QdItYW0GQR1XS
DSH1 Ml;MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXXTJJKSzVyPUCuNFM{OTRizszN NVHFXVNNW0GQR1XS
MDA-MB-175-VII NGPGWWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGf3d41KSzVyPUCuNFM1OTZizszN NYHxUo9VW0GQR1XS
NCI-H2170 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTBwMEO3Nlgh|ryP NFjydotUSU6JRWK=
BT-474 NYGzTYhuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDQN4k4UUN3ME2wMlA1QTh4IN88US=> MlnMV2FPT0WU
EFO-27 M1LVVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrLT|FKSzVyPUCuNFUyQDJizszN NH;UVHJUSU6JRWK=
NCI-H720 NXTxO29oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33veGlEPTB;MD6wOVMzPSEQvF2= MkPyV2FPT0WU
PC-14 M{LTbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17qVGlEPTB;MD6wOVY3QCEQvF2= NVjqbG8xW0GQR1XS
EC-GI-10 MnjrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\VUWVKSzVyPUCuNFU6OTJizszN M33oeHNCVkeHUh?=
KYSE-450 MlnhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTBwMEW5O|gh|ryP NXzMfWdtW0GQR1XS
BPH-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHT[4VSUUN3ME2wMlA2QTh6IN88US=> MkTlV2FPT0WU
NCI-H292 M3fSS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrZWWdKSzVyPUCuNFYxQSEQvF2= NF7qe4pUSU6JRWK=
H9 MlHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoeyTWM2OD1yLkC3NVMzKM7:TR?= MVTTRW5ITVJ?
NCI-H526 NY\sT5ZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTBwMEe4NlMh|ryP M4CwR3NCVkeHUh?=
NCI-H1623 NGXoPGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnKzTWM2OD1yLkC4NFI2KM7:TR?= M3HIN3NCVkeHUh?=
KYSE-140 NVfTem46T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfKTWM2OD1yLkC4N|Mh|ryP NGPpT29USU6JRWK=
Ca9-22 M1nsR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTBwMEizOVMh|ryP M4DL[XNCVkeHUh?=
AU565 NFvabY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;2TWM2OD1yLkC4OVA1KM7:TR?= MnXxV2FPT0WU
ZR-75-30 MlnRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTBwMEm1OFUh|ryP NVjnWXNXW0GQR1XS
NCI-H1770 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTBwMUCyPEDPxE1? M1HLdXNCVkeHUh?=
LB2241-RCC M37jXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXCO2hKSzVyPUCuNVA5QDRizszN MorJV2FPT0WU
CAL-39 NH\CTZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjLTWM2OD1yLkGxO|kzKM7:TR?= MkLSV2FPT0WU
UACC-893 NITtSnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jjOWlEPTB;MD6xNVg5PSEQvF2= M{\RZ3NCVkeHUh?=
LU-65 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGT6UnpKSzVyPUCuNVI3OzNizszN NEnoVJNUSU6JRWK=
HN MmXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTBwMUOwO|ch|ryP NVLHUlQ1W0GQR1XS
TI-73 M2\iNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDvUWZKSzVyPUCuNVQ4OTVizszN M1S1d3NCVkeHUh?=
KU812 MlLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHoXWtLUUN3ME2wMlE2PDV4IN88US=> M17mNnNCVkeHUh?=
SW13 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjOSFJKSzVyPUCuNVYzOTZizszN MVHTRW5ITVJ?
BB30-HNC NHTycGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTzeJFrUUN3ME2wMlE3PTd4IN88US=> MXTTRW5ITVJ?
HSC-2 M1;yVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvaTFA5UUN3ME2wMlE3QDN5IN88US=> NXzHO215W0GQR1XS
BV-173 NH:y[2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTBwMUe1PVYh|ryP MXvTRW5ITVJ?
CAL-27 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljlTWM2OD1yLkG3OlM3KM7:TR?= Mnr4V2FPT0WU
SBC-1 M175PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjTVY1TUUN3ME2wMlE5QTV7IN88US=> MkizV2FPT0WU
CAL-33 NFniUWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnX5TWM2OD1yLkKwNVg1KM7:TR?= MWPTRW5ITVJ?
NCI-H209 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHqeZZsUUN3ME2wMlIxPDZizszN MUDTRW5ITVJ?
COR-L105 NXLkOYhMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPCTWM2OD1yLkKxNFg1KM7:TR?= NYDNeppZW0GQR1XS
HSC-3 MkewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTBwMkGxPVgh|ryP NH;2O3VUSU6JRWK=
NCI-H69 MlnhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwMkG0OVEh|ryP MnjTV2FPT0WU
MOLT-13 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVL4SndyUUN3ME2wMlI{QTd3IN88US=> NF;0Sm9USU6JRWK=
ML-2 NH[wOYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELDbmpKSzVyPUCuNlQ5ODJizszN MkXTV2FPT0WU
IGROV-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7uR|IzUUN3ME2wMlI2QTV{IN88US=> M1fKNXNCVkeHUh?=
TK10 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTBwMk[3N|gh|ryP MU\TRW5ITVJ?
EoL-1-cell MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvUOGx2UUN3ME2wMlI3QDl{IN88US=> NIjhWXhUSU6JRWK=
HO-1-N-1 MkmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFn6cohKSzVyPUCuNlc5PTNizszN MkiwV2FPT0WU
BHY M2jpXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwMki2OVUh|ryP MUfTRW5ITVJ?
LU-139 NGC0[41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2i0W2lEPTB;MD6zNFUyKM7:TR?= MWrTRW5ITVJ?
23132-87 Ml\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwM{G5NlMh|ryP NH\jWGtUSU6JRWK=
ACHN M4PPcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLUeWc1UUN3ME2wMlMyQTl2IN88US=> NWnJRXZyW0GQR1XS
DoTc2-4510 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjaS4FKSzVyPUCuN|IzOTlizszN M3TWTXNCVkeHUh?=
BB65-RCC NHLPfpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDoSW1KSzVyPUCuN|Q2QTNizszN MX7TRW5ITVJ?
HLE MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3RSZF[UUN3ME2wMlM2ODR4IN88US=> M1O2WnNCVkeHUh?=
HCC1419 NFLETGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVX3VoRLUUN3ME2wMlM3PDB6IN88US=> MV\TRW5ITVJ?
A388 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXrc5dKSzVyPUCuN|Y5PTdizszN NITLWIpUSU6JRWK=
NUGC-3 M4SwTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYezeoZ1UUN3ME2wMlM5Ozd|IN88US=> MUnTRW5ITVJ?
KYSE-180 MnXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTBwM{mwPFkh|ryP M2\yT3NCVkeHUh?=
TE-6 NILLRWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;lOGM3UUN3ME2wMlQxOjR4IN88US=> M2fyeHNCVkeHUh?=
A498 M4G2[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rWSWlEPTB;MD60NFY4PCEQvF2= MWXTRW5ITVJ?
NCI-H1648 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTBwNESxPFIh|ryP MoGwV2FPT0WU
DU-145 MmnkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2D5PGlEPTB;MD60OFg{OyEQvF2= MluzV2FPT0WU
CW-2 NX76WnNkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnNd5llUUN3ME2wMlQ3QTF2IN88US=> NEP1XJJUSU6JRWK=
A431 NX\hTHVMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vDemlEPTB;MD60PFI{OyEQvF2= NIT1[4NUSU6JRWK=
SAS Mn30S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjmVphKSzVyPUCuOFg{QThizszN NW\6SYpXW0GQR1XS
NCI-H2126 M3;GUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml:zTWM2OD1yLkWxPVI3KM7:TR?= MorHV2FPT0WU
NCI-H358 Ml7nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnhUIVKSzVyPUCuOVMzOSEQvF2= NX3Lb2NrW0GQR1XS
FADU MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUWyOWpjUUN3ME2wMlU1PDB2IN88US=> M4\pbXNCVkeHUh?=
ACN NFToT3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHsPVdKSzVyPUCuOVUxQTRizszN M33YWHNCVkeHUh?=
HCC70 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPNVXM1UUN3ME2wMlU4PjZzIN88US=> MV3TRW5ITVJ?
NCI-H1838 NGfZWYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvsTIZKSzVyPUCuOlAzQTlizszN MVHTRW5ITVJ?
CAL-54 MlnZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTBwNkG2NlEh|ryP NX;TW3dkW0GQR1XS
NCI-H1975 M3n6[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HRTWlEPTB;MD62NVczQCEQvF2= MXrTRW5ITVJ?
COR-L88 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwNkSxNVMh|ryP M3z5Z3NCVkeHUh?=
CTV-1 M3[3b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HXR2lEPTB;MD62OFM6OiEQvF2= MmD3V2FPT0WU
EW-18 MoriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwNki2PVgh|ryP MUTTRW5ITVJ?
HCC1806 NXnjb4Z2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTBwNkm2OlYh|ryP NGrnOZNUSU6JRWK=
HuP-T4 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHkZll2UUN3ME2wMlY6PzZizszN MV7TRW5ITVJ?
MDA-MB-361 MluxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlj1TWM2OD1yLkeyOlYzKM7:TR?= MlrXV2FPT0WU
NCI-H1573 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlH2TWM2OD1yLkezOlMh|ryP M{HaOXNCVkeHUh?=
KU-19-19 NFnjVIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfvTWVLUUN3ME2wMlc4PDZ2IN88US=> M1npfXNCVkeHUh?=
COLO-678 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTBwOEC4N|Qh|ryP NVixSlVMW0GQR1XS
C-33-A MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTBwOEGyPVch|ryP Mki4V2FPT0WU
Calu-3 M4rhUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfjTWM2OD1yLkixOFM1KM7:TR?= M17XT3NCVkeHUh?=
AGS MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPuTWM2OD1yLkizOlQ5KM7:TR?= MUnTRW5ITVJ?
SCC-25 M1PXdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\5NW5KSzVyPUCuPFQyPzFizszN M4jJXHNCVkeHUh?=
JVM-2 M1\DO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwOEiyPVkh|ryP M{f5dHNCVkeHUh?=
HCE-T M1P6Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfsTWM2OD1yLki4OFI5KM7:TR?= MVXTRW5ITVJ?
ES4 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfx[HVKSzVyPUCuPVc5OzZizszN MoLEV2FPT0WU
EKVX MlHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3iTWM2OD1zLkCxNFY1KM7:TR?= Mk\JV2FPT0WU
D-542MG NGHnPWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;xN2lEPTB;MT6wNVA3PCEQvF2= M3HiR3NCVkeHUh?=
SW1116 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkH3TWM2OD1zLkCxNlg4KM7:TR?= MkHjV2FPT0WU
5637 NHrRUG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jv[WlEPTB;MT6wNVUyKM7:TR?= NV7zOoZKW0GQR1XS
HT-1376 MnHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfCNmRGUUN3ME2xMlAyPTF|IN88US=> MV;TRW5ITVJ?
NB69 MorJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTuTWM2OD1zLkCyPVQ2KM7:TR?= NGTCcllUSU6JRWK=
YKG-1 NFTQWXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1freWlEPTB;MT6wOVQyQSEQvF2= NUXtcIJoW0GQR1XS
EW-3 M{XCXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTFwMEe4PFMh|ryP M121WXNCVkeHUh?=
GCIY NXO4SFBQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTCRoJKSzVyPUGuNFgyODRizszN MXfTRW5ITVJ?
SK-MES-1 MoXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTWZ5NmUUN3ME2xMlEyPDh5IN88US=> NWDzOZdHW0GQR1XS
PANC-08-13 M3TsUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLLS4I5UUN3ME2xMlE3PDF4IN88US=> M3\CPHNCVkeHUh?=
SK-NEP-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvrTWM2OD1zLkG3OVE{KM7:TR?= MVHTRW5ITVJ?
SW954 NF7Je3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rkZ2lEPTB;MT6yNFIyPCEQvF2= MWrTRW5ITVJ?
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CAL-72 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M124PWlEPTB;MUCuPVM6OSEQvF2= NVi1ZmlCW0GQR1XS
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NCI-H650 NGO3e2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTFzLkK0NVgh|ryP M{jtVnNCVkeHUh?=
ALL-PO Mn3rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTFzLkK1NVIh|ryP NGLK[3JUSU6JRWK=
T84 Ml\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;DXmlEPTB;MUGuN|kxPyEQvF2= NX\yW29MW0GQR1XS
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SW626 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fkTWlEPTB;MUGuOVc2PSEQvF2= NHSzUI9USU6JRWK=
RPMI-2650 NIXsSXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTFzLkW4PFUh|ryP M{\xdnNCVkeHUh?=
MC-IXC MnvNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLoNnl4UUN3ME2xNU43PzJ6IN88US=> NUe0dI5{W0GQR1XS
HOP-62 M1H3TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTFzLk[3OlQh|ryP MYTTRW5ITVJ?
NOS-1 M325U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPqZpczUUN3ME2xNU44OTB7IN88US=> M2HocXNCVkeHUh?=
SW1573 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7GNHF4UUN3ME2xNU44Ojl3IN88US=> NELob3dUSU6JRWK=
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HuO9 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPVeoNKSzVyPUGxMlg4PzRizszN MoL1V2FPT0WU
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MDA-MB-453 NGrwPJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\OO4dWUUN3ME2xNU46PTF3IN88US=> M4DxXXNCVkeHUh?=
NCI-H596 MoTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fmN2lEPTB;MUKuNFM3QSEQvF2= NF;DRXZUSU6JRWK=
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SW837 MonCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkL3TWM2OD1zMj65NFI5KM7:TR?= Mlm1V2FPT0WU
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PFSK-1 MmTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILVfXlKSzVyPUGzMlA3KM7:TR?= NYTXcnJOW0GQR1XS
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OVCAR-5 NWLiO3dNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTF|LkG1PVMh|ryP MYXTRW5ITVJ?
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Ramos-2G6-4C10 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTF2LkCyNFIh|ryP Mn7XV2FPT0WU
EW-13 NHfOU|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLHdpdKSzVyPUG0MlA{PTJizszN NXO0OnR2W0GQR1XS
NCI-H1793 NXXhTJJWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTF2LkKwPFch|ryP NIXPSnBUSU6JRWK=
BHT-101 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPVTWM2OD1zND6yOFEh|ryP MljJV2FPT0WU
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NCI-H2030 MoP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTF2Lk[0OFgh|ryP MU\TRW5ITVJ?
C2BBe1 Mo\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGGwR5pKSzVyPUG0Mlc3PCEQvF2= M1XhS3NCVkeHUh?=
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HCC1395 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTF2LkmzN|gh|ryP NH\DWpdUSU6JRWK=
A2058 NITKdm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHW4TYZKSzVyPUG1MlA1ODlizszN M3mxdHNCVkeHUh?=
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COLO-824 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3oXmxZUUN3ME2xOU4yPTd7IN88US=> MWXTRW5ITVJ?
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CP66-MEL MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3lVmRKSzVyPUG1MlQ3QDhizszN M{HiOXNCVkeHUh?=
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OVCAR-8 NXexWlRZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\JWWlEPTB;MUWuPFg3OSEQvF2= MXPTRW5ITVJ?
MFE-280 MmGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jvV2lEPTB;MU[uNFQ5QCEQvF2= NYnxcZZbW0GQR1XS
MHH-NB-11 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TUdmlEPTB;MU[uNFg{QSEQvF2= MmO5V2FPT0WU
SW1990 MmPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHLTWM2OD1zNj6xO|U2KM7:TR?= Mme4V2FPT0WU
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MFM-223 MlXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTF4LkO5OlUh|ryP MVHTRW5ITVJ?
L-363 NV\2XFdVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYm3XIhVUUN3ME2xOk41PTd5IN88US=> MWnTRW5ITVJ?
MCF7 NXzCVllpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWS5SW9SUUN3ME2xOk41PzJ|IN88US=> MoL5V2FPT0WU
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QIMR-WIL M4DFRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37VU2lEPTB;MU[uO|ExPSEQvF2= NIn2NppUSU6JRWK=
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COLO-684 NHLuXYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrnTWM2OD1zNj65OFc4KM7:TR?= NWHkPFJyW0GQR1XS
NCI-H661 Mo\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\DTWM2OD1zNj65Olk1KM7:TR?= M3izUnNCVkeHUh?=
CP50-MEL-B MlfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTF5LkCzOFMh|ryP MlrGV2FPT0WU
NCI-H2405 NVP4VXR2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rse2lEPTB;MUeuNVk4PCEQvF2= MY\TRW5ITVJ?
U-2-OS NILpV2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTF5LkWzNFch|ryP NHL1NohUSU6JRWK=
RERF-LC-MS Ml\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnzTWM2OD1zNz61OVA5KM7:TR?= NGXnR4VUSU6JRWK=
NCI-H2342 M2XhXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTF5LkW1O{DPxE1? M3zPdnNCVkeHUh?=
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MOLT-16 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHaTWM2OD1zNz64PVM1KM7:TR?= NH:zXmpUSU6JRWK=
RH-18 MnGxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTF6LkCwN|Uh|ryP NYG3eZJRW0GQR1XS
D-283MED MoC5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkf2TWM2OD1zOD6wNFg5KM7:TR?= MkTNV2FPT0WU
RCC10RGB M{Hxcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\RWpp6UUN3ME2xPE4xPTV7IN88US=> NFLobodUSU6JRWK=
NCI-H1437 M1Hpbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTkTWM2OD1zOD6xOlQyKM7:TR?= NV3U[XV2W0GQR1XS
SW982 MnHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTF6LkK2O|Eh|ryP M3[xUnNCVkeHUh?=
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A704 NH3FRnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTF6LkS3OVMh|ryP NGf1THhUSU6JRWK=
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LU-135 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vTUGlEPTB;M{OuPFgzQSEQvF2= M3nKdnNCVkeHUh?=
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T-24 Mm\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1ztdGlEPTB;M{SuNFIxPSEQvF2= MoHqV2FPT0WU
Mewo MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfDTWM2OD1|ND6xN|Q6KM7:TR?= NHfoUXBUSU6JRWK=
22RV1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4O2NmlEPTB;M{SuNVc2PCEQvF2= M{m0eXNCVkeHUh?=
KM-H2 NHnB[|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljaTWM2OD1|ND6xO|c6KM7:TR?= NYDFNY5ZW0GQR1XS
NCI-H2122 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTN2LkO0O|Eh|ryP NVH0fJFPW0GQR1XS
ABC-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHWTWM2OD1|ND6zOlk{KM7:TR?= NF60foRUSU6JRWK=
NCI-H1355 NUn2VGZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rqN2lEPTB;M{SuN|g5QSEQvF2= MoXFV2FPT0WU
NOMO-1 NFXz[XdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml[4TWM2OD1|ND61O|A{KM7:TR?= NF3KPYhUSU6JRWK=
MZ7-mel Mn:2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;kTWM2OD1|ND62OFg4KM7:TR?= MmnOV2FPT0WU
NCI-H810 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTN2LkeyO|gh|ryP M3fZS3NCVkeHUh?=
D-392MG Ml;rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XMOGlEPTB;M{WuNFU3PSEQvF2= NHm5OpJUSU6JRWK=
LB771-HNC M1:wPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXSxOJdLUUN3ME2zOU4yPjV6IN88US=> MV\TRW5ITVJ?
COLO-679 NXf6ZpIyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnjTWM2OD1|NT6zPFgh|ryP Mn\GV2FPT0WU
SK-PN-DW Mn\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;TVphKUUN3ME2zOU41OzZ7IN88US=> NHPyT5NUSU6JRWK=
VA-ES-BJ MmfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILWXmtKSzVyPUO1MlQ3PDlizszN M4rVb3NCVkeHUh?=
KNS-42 Mn\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3HPFNlUUN3ME2zOU42QDJ4IN88US=> MX3TRW5ITVJ?
RVH-421 M4fMZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHxdolKSzVyPUO1Mlc3PDVizszN MnzZV2FPT0WU
P30-OHK NHLETVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3S5O2lEPTB;M{WuPFc2OiEQvF2= MYfTRW5ITVJ?
G-402 NG\rVJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjOOIZWUUN3ME2zOU46QDZ5IN88US=> NFLkcXNUSU6JRWK=
S-117 NF\PVmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{n1R2lEPTB;M{[uN|AxQCEQvF2= NXPvW4U1W0GQR1XS
RXF393 M3u3dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTN4LkO3PFUh|ryP MX7TRW5ITVJ?
LCLC-103H NWq0SndST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{WyPWlEPTB;M{[uO|gxOyEQvF2= NGLIUVhUSU6JRWK=
U-118-MG NUHKVpByT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{Xs[2lEPTB;M{[uPFg1PyEQvF2= MWrTRW5ITVJ?
8-MG-BA MnjpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWD0UVJ7UUN3ME2zOk46PDh|IN88US=> MXPTRW5ITVJ?
MFH-ino MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTN5LkOzO|Eh|ryP MXXTRW5ITVJ?
NCI-H23 NF\ZfohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fu[2lEPTB;M{euOFE6PiEQvF2= MnvwV2FPT0WU
NCI-H446 M2K2O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\ETWM2OD1|Nz60PFYzKM7:TR?= MWXTRW5ITVJ?
LU-99A MlTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTqTWM2OD1|Nz61O|MyKM7:TR?= NELoe4FUSU6JRWK=
KP-N-YN NV;CWIt3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\YTWM2OD1|Nz62NVk2KM7:TR?= MUPTRW5ITVJ?
SCC-9 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\GOIlvUUN3ME2zO{44QDN6IN88US=> Ml3RV2FPT0WU
EFM-19 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTqTWM2OD1|Nz63PVY4KM7:TR?= NWLZWph5W0GQR1XS
A427 NHfuS21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7QW4lKSzVyPUO3MlkyODdizszN MV;TRW5ITVJ?
LB831-BLC NF23NINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTN6Lk[wN|kh|ryP MlLvV2FPT0WU
HOS MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVj5RpNZUUN3ME2zPU43Ojd|IN88US=> M4HyXnNCVkeHUh?=
LAN-6 MofIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnWVpl7UUN3ME20NE4xOTF{IN88US=> NHvHWppUSU6JRWK=
U251 MmjYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTRyLkSwOVQh|ryP NILYWY9USU6JRWK=
SNU-387 NFracVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;EPIhKSzVyPUSwMlQ2PTNizszN M{DxO3NCVkeHUh?=
DMS-79 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn[xTWM2OD12MD61PFg6KM7:TR?= M2myNnNCVkeHUh?=
SK-LU-1 Mm\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjGVpdKSzVyPUSwMlY2PjhizszN NYHxO4JHW0GQR1XS
HT M4jvOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvMRZNKSzVyPUSwMlY3OzlizszN MmrBV2FPT0WU
KP-N-YS MljhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfIVY1KSzVyPUSwMlY4PjhizszN NIDVUWJUSU6JRWK=
DMS-114 NF7kSmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LLd2lEPTB;NECuPFM4PCEQvF2= M4LPR3NCVkeHUh?=
HUTU-80 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTDZVhlUUN3ME20NU4xPTZ7IN88US=> Moj5V2FPT0WU
ONS-76 NIfCdmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fqeWlEPTB;NEGuOFcxQSEQvF2= MlPLV2FPT0WU
A673 NV;hOnhvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTRzLkWxOVch|ryP MV7TRW5ITVJ?
HPAF-II NVnBcpRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPsTWM2OD12MT62O|A6KM7:TR?= NVzoUoM3W0GQR1XS
UACC-257 M4q4Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDOTWM2OD12MT63N|Y6KM7:TR?= MWDTRW5ITVJ?
EW-22 NVLDN|YzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTRzLki2PVch|ryP NIDo[VJUSU6JRWK=
NCI-H1755 NFzxS49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{Phd2lEPTB;NEGuPFczPSEQvF2= M{PNcHNCVkeHUh?=
KYSE-150 Ml73S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIC0XYtKSzVyPUSyMlE4QDJizszN M2\vdnNCVkeHUh?=
CGTH-W-1 M2\XSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTLTWM2OD12Mj60PVU2KM7:TR?= NH3MbIRUSU6JRWK=
NB13 NVvCS5hPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX:5TI1PUUN3ME20Nk43OjF5IN88US=> M4nxOHNCVkeHUh?=
SW872 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvBTWM2OD12Mj62N|MyKM7:TR?= Mm[0V2FPT0WU
KP-4 M{TXNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTR{Lki4N|Ih|ryP MVLTRW5ITVJ?
HCC38 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;HcWpRUUN3ME20Nk46PjF6IN88US=> NX:2fFNDW0GQR1XS
BB49-HNC NGS1VWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHGTWM2OD12Mz6yN|U3KM7:TR?= M{jOV3NCVkeHUh?=
CAL-62 M{[z[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;yc2lKSzVyPUSzMlQxOjhizszN MlfYV2FPT0WU
NCI-H2029 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlv2TWM2OD12Mz61OVgyKM7:TR?= Mo\PV2FPT0WU
M14 MmPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTR2LkGzN|Ih|ryP MYrTRW5ITVJ?
COLO-680N NY\Pc4pYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zYUGlEPTB;NESuN|M6KM7:TR?= MmrjV2FPT0WU
Hs-578-T MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTR3LkCyPVQh|ryP M4r3UnNCVkeHUh?=
MSTO-211H M1HkV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPSTWM2OD12NT65OFgzKM7:TR?= NWnZcpkxW0GQR1XS
EW-1 Mk\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLYWYFKSzVyPUS1Mlk3QDlizszN M37oW3NCVkeHUh?=
SW948 Mlr4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjpW3d6UUN3ME20Ok41PDZ{IN88US=> MYfTRW5ITVJ?
NCI-H460 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFyzbotKSzVyPUS2MlUzOyEQvF2= NHzwVo5USU6JRWK=
CAS-1 NEKxSGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLUR4NFUUN3ME20Ok44PzBzIN88US=> MWfTRW5ITVJ?
TGBC11TKB NVHTWpR4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\DZlE4UUN3ME20O{4yPzd5IN88US=> NIG2RZFUSU6JRWK=
HD-MY-Z Mn7mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlf3TWM2OD12OD63PFYh|ryP NXTEV5g2W0GQR1XS
NCI-H226 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfEXIxbUUN3ME20PU44Pzh3IN88US=> Mn7FV2FPT0WU
PA-1 NILYOpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnTTWM2OD12OT64N|M2KM7:TR?= NXLQb2Y{W0GQR1XS
LB2518-MEL M2PrWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\oUIxjUUN3ME20PU45PzJ|IN88US=> NX\IO5NXW0GQR1XS
A101D NEDBNJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fEbmlEPTB;NEmuPVQzPSEQvF2= NF[zdZJUSU6JRWK=
NCI-H2087 NUPNNYI6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3lWZhDUUN3ME20PU46Pjh{IN88US=> M{W0enNCVkeHUh?=

... Click to View More Cell Line Experimental Data

体内研究 活体研究时按实验对象体重,每千克口服20 mg BIBW2992持续25天,肿瘤产生明显的衰退现象,通过肿瘤切片的免疫组织化学染色观察发现,EGFR和AKT的磷酸化作用收到抑制。因此,正如lapatinib和neratinib, BIBW2992是次代酪氨酸激酶抑制剂,不可逆地抑制人类EGFR2(HER2)和EGFR激酶。BIBW2992不仅能和原代酪氨酸激酶如erlotinib和gefitinib一样有效抑制EGFR突变型,而且还能作用于抗erlotinib和gefitinib的EGFR。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

+ 展开

体外激酶活性实验:

人类EGFR和L858R/T790M双重突变型EGFR 的酪氨酸激酶区域与谷胱甘肽巯基转移酶区域相接,提取酪氨酸激酶区域的方法见补充说明。在有和没有BIBW2992时分别测定酶活。使用杆状病毒系统克隆HER2激酶,用类似提取EGFR激酶域的方法提取HER2激酶域。
细胞实验:

[1]

+ 展开
  • Cell lines: NSCLC细胞
  • Concentrations: 0-10 μM
  • Incubation Time: 1小时
  • Method:

    细胞按1×104密度转移到96孔板上,在无血清培养基上过夜培养,用于EGFR磷酸化实验。第二天添加包含BIBW2992的混合物,培养基在37oC温育1小时。在室温下用100 ng/ml EGF刺激10分钟。细胞用冰冻PBS冲洗,然后每孔用120 μl HEPEX buffer萃取,然后在室温下震荡1小时。每孔中所有2×104细胞都用于HER2磷酸化实验。在涂有链霉亲和素的板上加用封闭液按1:100比例稀释的抗EGFR的生物素和c-erb2/HER2肿瘤蛋白Ab-5-生物素。上述步骤得到的萃取物转移到有抗体包被的孔中,室温下温育1小时。彩色显影的测法见补充说明,吸光度为450纳米。


    (Only for Reference)
动物实验:

[1]

+ 展开
  • Animal Models: 雌性无胸腺NMRI-nu/nu鼠
  • Formulation: 0.5%甲基纤维素-0.4% Tween-80
  • Dosages: 20 mg/kg
  • Administration: 口服处理
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 97 mg/mL (199.61 mM)
Ethanol 15 mg/mL (30.86 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
10mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 485.94
化学式

C24H25ClFN5O3

CAS号 439081-18-2
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02780687 Recruiting Urologic Neoplasms Boehringer Ingelheim June 9 2016 Phase 2
NCT02131259 Completed Carcinoma Non-Small-Cell Lung Boehringer Ingelheim May 7 2014 --
NCT02216617 Completed HNSCC Groupe Oncologie Radiotherapie Tete et Cou August 6 2014 Phase 1
NCT02451553 Recruiting Advanced Malignant Solid Neoplasm|Bile Duct Carcinoma|Recurrent Malignant Solid Neoplasm|Recurrent Pancreatic Carcinoma|Stage III Pancreatic Cancer AJCC v6 and v7|Stage IVA Pancreatic Cancer|Stage IVB Pancreatic Cancer University of Washington|National Cancer Institute (NCI) November 5 2015 Phase 1
NCT01523587 Completed Carcinoma Non-Small-Cell Lung Boehringer Ingelheim March 5 2012 Phase 3
NCT01345682 Completed Head and Neck Neoplasms|Carcinoma Squamous Cell Boehringer Ingelheim January 5 2012 Phase 3

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • 回答:

    For in vivo experiment of afatinib, we recommend 0.5% methylcellulose/0.2% Tween 80 as vehicle.

EGFR Signaling Pathway Map

EGFR Inhibitors with Unique Features

相关EGFR产品

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID