Afatinib (BIBW2992)

目录号:S1011

Afatinib (BIBW2992) Chemical Structure

Molecular Weight(MW): 485.94

Afatinib (BIBW2992)不可逆地抑制EGFR/ErbB,包括EGFR(wt)EGFR(L858R),EGFR(L858R/T790M),ErbB2(HER2)和ErbB4(HER4),在无细胞试验中IC50分别为0.5 nM,0.4 nM,10 nM,14 nM和1 nM。

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RMB 1964.25 现货
RMB 977.68 现货
RMB 1724.11 现货
RMB 4652.69 现货
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客户使用Selleck该产品发表文献38篇:

产品安全说明书

EGFR抑制剂选择性比较

生物活性

产品描述 Afatinib (BIBW2992)不可逆地抑制EGFR/ErbB,包括EGFR(wt)EGFR(L858R),EGFR(L858R/T790M),ErbB2(HER2)和ErbB4(HER4),在无细胞试验中IC50分别为0.5 nM,0.4 nM,10 nM,14 nM和1 nM。
靶点
EGFR (L858R) [1]
(Cell-free assay)
EGFR (wt) [1]
(Cell-free assay)
ErbB4 [2]
(Cell-free assay)
EGFR (L858R/T790M) [1]
(Cell-free assay)
HER2 [1]
(Cell-free assay)
0.4 nM 0.5 nM 1 nM 10 nM 14 nM
体外研究

BIBW2992不可逆地抑制EGFR/HER2,在体外作用于野生型EGFR ,L858R突变型EGFR, L858R/T790M 双突变型EGFR,及HER2时IC50分别为0.5, 0.4, 10, 14 nM。在体外实验中,BIBW2992不管作用于野生型EGFR/HER2还是突变型EGFR/HER2都显示出强大的活力,与gefitinib作用于L858R突变型EGFR的活力差不多,但是要比gefitinib 作用于L858R-T790M双突变型EGFR的活力大100倍。在体外,BIBW2992有效抑制所有实验类型细胞的EGFR/HER磷酸化作用。比如人类扁平上皮癌A431细胞系表达的野生型EGFR, 鼠类NIH-3T3细胞转染的野生型HER2 , 以及乳腺癌BT-474细胞系和胃癌NCI-N87细胞系表达的内源性HER2。[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HDLM-2 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTBwMEC1O|Ih|ryP MoPyV2FPT0WU
KASUMI-1 M2naN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHwNog1UUN3ME2wMlAxQTFzIN88US=> NWXzb|c6W0GQR1XS
HCC2218 NFPkTHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPNTWM2OD1yLkCwPVg4KM7:TR?= MmLvV2FPT0WU
KARPAS-45 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nMeWlEPTB;MD6wNVY4OSEQvF2= M4[wenNCVkeHUh?=
HSC-4 NHHveYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLQNWFIUUN3ME2wMlAyPzR6IN88US=> NVHjPYVsW0GQR1XS
CHL-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jUTmlEPTB;MD6wNVg{QSEQvF2= MorTV2FPT0WU
KY821 NIf6O4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLDOplTUUN3ME2wMlAzODZizszN MXHTRW5ITVJ?
NCI-N87 M36wU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\ZcXhKSzVyPUCuNFI4PzNizszN M2ntW3NCVkeHUh?=
DOK NW\SN2llT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrEOYRKSzVyPUCuNFMyQTRizszN Mnn4V2FPT0WU
DSH1 M3vneWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PJ[WlEPTB;MD6wN|MyPCEQvF2= Mkn4V2FPT0WU
MDA-MB-175-VII MlTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rzd2lEPTB;MD6wN|QyPiEQvF2= NXLXVpllW0GQR1XS
NCI-H2170 M{\ndGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFz4N3RKSzVyPUCuNFM4OjhizszN NUXrZpd4W0GQR1XS
BT-474 MkfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HDPWlEPTB;MD6wOFk5PiEQvF2= MVzTRW5ITVJ?
EFO-27 M3v6Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrjTWM2OD1yLkC1NVgzKM7:TR?= NF[0NGpUSU6JRWK=
NCI-H720 NYHEb5p6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXud4lKSzVyPUCuNFU{OjVizszN MYDTRW5ITVJ?
PC-14 NHO3R5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHyelBKSzVyPUCuNFU3PjhizszN NF65RYRUSU6JRWK=
EC-GI-10 Mkf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rERmlEPTB;MD6wOVkyOiEQvF2= NGDkRoFUSU6JRWK=
KYSE-450 M2C3fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDXWWl[UUN3ME2wMlA2QTd6IN88US=> NU\ySIs2W0GQR1XS
BPH-1 Mk\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHhWoRKSzVyPUCuNFU6QDhizszN NVrUV3p4W0GQR1XS
NCI-H292 NG\DfmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUS1Wod6UUN3ME2wMlA3ODlizszN NFX6WFRUSU6JRWK=
H9 NX76WlNkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjydXZKSzVyPUCuNFcyOzJizszN MYfTRW5ITVJ?
NCI-H526 M1fzVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTJfGFKSzVyPUCuNFc5OjNizszN NF7LeFRUSU6JRWK=
NCI-H1623 NHrKdFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUi0dnU4UUN3ME2wMlA5ODJ3IN88US=> NWLMSXM6W0GQR1XS
KYSE-140 Mo[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3foPWlEPTB;MD6wPFM{KM7:TR?= MXHTRW5ITVJ?
Ca9-22 NHrpb|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXIXZNYUUN3ME2wMlA5OzV|IN88US=> MYfTRW5ITVJ?
AU565 M1OwTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2[wVGlEPTB;MD6wPFUxPCEQvF2= NF60XY1USU6JRWK=
ZR-75-30 NFXxVlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTBwMEm1OFUh|ryP MnLRV2FPT0WU
NCI-H1770 M1OzVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7WW2NKSzVyPUCuNVAzQCEQvF2= MnnwV2FPT0WU
LB2241-RCC MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwMUC4PFQh|ryP NHXPUphUSU6JRWK=
CAL-39 M2L2NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XkeWlEPTB;MD6xNVc6OiEQvF2= MnTpV2FPT0WU
UACC-893 NVPsSnVmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXkWndMUUN3ME2wMlEyQDh3IN88US=> M1mzN3NCVkeHUh?=
LU-65 NWrYPXVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPaeHRKSzVyPUCuNVI3OzNizszN NIPyS3NUSU6JRWK=
HN NV7jTI9WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjieIhKSzVyPUCuNVMxPzdizszN MXPTRW5ITVJ?
TI-73 M1T6TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XpfmlEPTB;MD6xOFcyPSEQvF2= NHj5PIxUSU6JRWK=
KU812 NEDh[|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjSbZFKSzVyPUCuNVU1PTZizszN M{LQVHNCVkeHUh?=
SW13 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1W4ZmlEPTB;MD6xOlIyPiEQvF2= MWjTRW5ITVJ?
BB30-HNC M4f6SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTBwMU[1O|Yh|ryP M{DGZ3NCVkeHUh?=
HSC-2 MmnjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYL1fol1UUN3ME2wMlE3QDN5IN88US=> NVzK[XdoW0GQR1XS
BV-173 NWDwR3Y5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXT2VI04UUN3ME2wMlE4PTl4IN88US=> MWXTRW5ITVJ?
CAL-27 NYrnZ3BJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjPT5NKSzVyPUCuNVc3OzZizszN NHLVOoRUSU6JRWK=
SBC-1 NWrxVII5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTIWJZKSzVyPUCuNVg6PTlizszN MlzTV2FPT0WU
CAL-33 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTBwMkCxPFQh|ryP NVfsSYhsW0GQR1XS
NCI-H209 NVrKTVIyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jJVGlEPTB;MD6yNFQ3KM7:TR?= NWXtOoYyW0GQR1XS
COR-L105 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTBwMkGwPFQh|ryP NEHTS29USU6JRWK=
HSC-3 MmXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3q1dWlEPTB;MD6yNVE6QCEQvF2= MXzTRW5ITVJ?
NCI-H69 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPMXpRuUUN3ME2wMlIyPDVzIN88US=> NW\P[5BKW0GQR1XS
MOLT-13 NH3RS|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWL1[Hh6UUN3ME2wMlI{QTd3IN88US=> MVzTRW5ITVJ?
ML-2 NXrUdZR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\iUIlKSzVyPUCuNlQ5ODJizszN NEjlbJdUSU6JRWK=
IGROV-1 M2DWNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLIU2xKSzVyPUCuNlU6PTJizszN NI\4TlFUSU6JRWK=
TK10 NGDFPIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwMk[3N|gh|ryP NF3X[FBUSU6JRWK=
EoL-1-cell NWLxc4FxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHy2VVhKSzVyPUCuNlY5QTJizszN M33BdXNCVkeHUh?=
HO-1-N-1 MojnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTBwMke4OVMh|ryP M37Jb3NCVkeHUh?=
BHY NFHCdopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnTZ3hLUUN3ME2wMlI5PjV3IN88US=> MVTTRW5ITVJ?
LU-139 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTBwM{C1NUDPxE1? M{K4eXNCVkeHUh?=
23132-87 MkfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17TSGlEPTB;MD6zNVkzOyEQvF2= NVTkeWhVW0GQR1XS
ACHN MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HVUWlEPTB;MD6zNVk6PCEQvF2= Mn3yV2FPT0WU
DoTc2-4510 M17FOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzJTWM2OD1yLkOyNlE6KM7:TR?= MWrTRW5ITVJ?
BB65-RCC M1f6W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrDVGdKSzVyPUCuN|Q2QTNizszN MkXxV2FPT0WU
HLE NFTESYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1H1S2lEPTB;MD6zOVA1PiEQvF2= M{HDSXNCVkeHUh?=
HCC1419 NFi3bFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzOXIJKSzVyPUCuN|Y1ODhizszN NXP4bm5QW0GQR1XS
A388 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2m0eWlEPTB;MD6zOlg2PyEQvF2= NILGSJRUSU6JRWK=
NUGC-3 M4DYfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnKzTWM2OD1yLkO4N|c{KM7:TR?= NHKzN|VUSU6JRWK=
KYSE-180 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjLV3pKSzVyPUCuN|kxQDlizszN MWHTRW5ITVJ?
TE-6 NWmxSHZ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTBwNECyOFYh|ryP NHPadHlUSU6JRWK=
A498 NWTZe|hbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrnWJRKSzVyPUCuOFA3PzRizszN M4L6Z3NCVkeHUh?=
NCI-H1648 M3niZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zVV2lEPTB;MD60OFE5OiEQvF2= MYTTRW5ITVJ?
DU-145 M4\VbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{i1ZWlEPTB;MD60OFg{OyEQvF2= Mn\YV2FPT0WU
CW-2 NGXscmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHoTWM2OD1yLkS2PVE1KM7:TR?= NHjRTlRUSU6JRWK=
A431 Ml7qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwNEiyN|Mh|ryP NX3mT4trW0GQR1XS
SAS NWfVR|NCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLLV2dKSzVyPUCuOFg{QThizszN MWPTRW5ITVJ?
NCI-H2126 NH;Db2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnK5TWM2OD1yLkWxPVI3KM7:TR?= NYDifGtwW0GQR1XS
NCI-H358 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLwTWM2OD1yLkWzNlEh|ryP NWTzb49rW0GQR1XS
FADU NFrVWIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXq2R|VVUUN3ME2wMlU1PDB2IN88US=> M1zrNHNCVkeHUh?=
ACN MmrQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTBwNUWwPVQh|ryP NXXlTJRRW0GQR1XS
HCC70 M2\BPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHiTWM2OD1yLkW3OlYyKM7:TR?= MWHTRW5ITVJ?
NCI-H1838 M4XGdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rYeWlEPTB;MD62NFI6QSEQvF2= NF22[FFUSU6JRWK=
CAL-54 Mn3ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwNkG2NlEh|ryP NXTRUmx7W0GQR1XS
NCI-H1975 NXrCfI1VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwNkG3Nlgh|ryP MVnTRW5ITVJ?
COR-L88 NXLnT4FNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTBwNkSxNVMh|ryP MlfYV2FPT0WU
CTV-1 NF;aUm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTaPJltUUN3ME2wMlY1Ozl{IN88US=> Mk\YV2FPT0WU
EW-18 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXzXnlbUUN3ME2wMlY5Pjl6IN88US=> MVLTRW5ITVJ?
HCC1806 NXzGbldpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvFO29KSzVyPUCuOlk3PjZizszN M3HoXnNCVkeHUh?=
HuP-T4 NXjN[ZlST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTH[Ys6UUN3ME2wMlY6PzZizszN MV\TRW5ITVJ?
MDA-MB-361 NEnOSZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWmwRXg1UUN3ME2wMlczPjZ{IN88US=> MmmyV2FPT0WU
NCI-H1573 MlT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjwU3lKSzVyPUCuO|M3OyEQvF2= NHToNYhUSU6JRWK=
KU-19-19 M1v6NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULFNpJTUUN3ME2wMlc4PDZ2IN88US=> MmrvV2FPT0WU
COLO-678 M2XBZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\WWW1KSzVyPUCuPFA5OzRizszN MXXTRW5ITVJ?
C-33-A MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnr2TWM2OD1yLkixNlk4KM7:TR?= NF7lRpVUSU6JRWK=
Calu-3 M330U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTBwOEG0N|Qh|ryP MnmxV2FPT0WU
AGS MoHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXiTWM2OD1yLkizOlQ5KM7:TR?= M3f6fnNCVkeHUh?=
SCC-25 MmXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnjdVJKSzVyPUCuPFQyPzFizszN M2nrWHNCVkeHUh?=
JVM-2 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHewUplKSzVyPUCuPFgzQTlizszN Mn:xV2FPT0WU
HCE-T Mk\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHXTWM2OD1yLki4OFI5KM7:TR?= M{jFNnNCVkeHUh?=
ES4 NVP5Rm1iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHSTnZYUUN3ME2wMlk4QDN4IN88US=> NFTVUolUSU6JRWK=
EKVX MkTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlSzTWM2OD1zLkCxNFY1KM7:TR?= NXHkW4J7W0GQR1XS
D-542MG MlzVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rsT2lEPTB;MT6wNVA3PCEQvF2= NEHjPXRUSU6JRWK=
SW1116 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonwTWM2OD1zLkCxNlg4KM7:TR?= NEG0c5NUSU6JRWK=
5637 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPHZ3RKSzVyPUGuNFE2OSEQvF2= MojhV2FPT0WU
HT-1376 NUDldXJOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7NdpdKSzVyPUGuNFE2OTNizszN MmryV2FPT0WU
NB69 NEXVUW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M335TGlEPTB;MT6wNlk1PSEQvF2= MXPTRW5ITVJ?
YKG-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPaTWM2OD1zLkC1OFE6KM7:TR?= NX7pPVVjW0GQR1XS
EW-3 NXLxU4lNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jsb2lEPTB;MT6wO|g5OyEQvF2= M2LsenNCVkeHUh?=
GCIY MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHpeXNNUUN3ME2xMlA5OTB2IN88US=> NUfEPIJ7W0GQR1XS
SK-MES-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTFwMUG0PFch|ryP MUTTRW5ITVJ?
PANC-08-13 MknXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTFwMU[0NVYh|ryP MYPTRW5ITVJ?
SK-NEP-1 MmrGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLV[WNHUUN3ME2xMlE4PTF|IN88US=> NFm1XVdUSU6JRWK=
SW954 MmexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFeyblRKSzVyPUGuNlAzOTRizszN MV;TRW5ITVJ?
NCI-SNU-5 M1jqcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTFwMkO5JO69VQ>? NVP0SodsW0GQR1XS
SW48 Mn;pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDUUWlKSzVyPUGuNlU1OzJizszN NEW4PZhUSU6JRWK=
HT-3 M2TCSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{Xoc2lEPTB;MT6yPFc2OyEQvF2= M4S3S3NCVkeHUh?=
ETK-1 MnX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTFwM{e0OVYh|ryP MWnTRW5ITVJ?
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OAW-28 NGrwNFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrKS5RXUUN3ME23Mlk1PTd6IN88US=> NFXjTWFUSU6JRWK=
KURAMOCHI NXHyTpF4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUX0blN5UUN3ME23Mlk1QDFzIN88US=> NEPNZ2xUSU6JRWK=
BE-13 NV:2OpFlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV72XpJKUUN3ME23Mlk5OTF{IN88US=> M3rOdnNCVkeHUh?=
VMRC-RCZ NG[zZZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPWPJZKSzVyPUiuNFE3QTdizszN NV75W5hiW0GQR1XS
NCI-H727 NEjYellIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPCW4xKSzVyPUiuNVA1OiEQvF2= NFHGV3lUSU6JRWK=
SW1710 Mn36S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWr3V|lzUUN3ME24MlE5PTF3IN88US=> MXTTRW5ITVJ?
D-502MG Mm\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRThwMkmyPFIh|ryP NWXOcZZZW0GQR1XS
NCI-H1993 NWD2Tlg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjKTWM2OD16LkOzOlMyKM7:TR?= MYDTRW5ITVJ?
SCC-4 M2XDSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\KOJRKSzVyPUiuOFQxPTlizszN NVn2fINyW0GQR1XS
HAL-01 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDTTWM2OD16LkWxPVEh|ryP MlW3V2FPT0WU
GT3TKB MmP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HJNmlEPTB;OD62O|k3PCEQvF2= M2nnenNCVkeHUh?=
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COLO-829 MnLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTyTWM2OD16LkiwPVc3KM7:TR?= NWfONFhYW0GQR1XS
OCI-AML2 Mn\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFT4c|BKSzVyPUiuPVU1QDFizszN MmPiV2FPT0WU
OS-RC-2 NUf5V2JWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;CTWM2OD17LkCyNVkh|ryP Mo\NV2FPT0WU
BFTC-909 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfZVlY5UUN3ME25MlA3Pzl7IN88US=> M3vLfXNCVkeHUh?=
EW-11 M4W3[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfoTWM2OD17LkG3OlU{KM7:TR?= M2\lV3NCVkeHUh?=
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BALL-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETiUXZKSzVyPUmuNlE6ODdizszN NYixO2xmW0GQR1XS
SF539 NHy2[FRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XrZmlEPTB;OT6yN|U3OiEQvF2= M1jhV3NCVkeHUh?=
CAMA-1 NIftZVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXT6cpRQUUN3ME25MlI5OTJ6IN88US=> M1fqfnNCVkeHUh?=
C32 M2fkS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTlwM{OwOlQh|ryP NUm4Z5JUW0GQR1XS
NCI-H1703 M3fzRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nnSmlEPTB;OT6zOFM4PSEQvF2= MnTFV2FPT0WU
NCI-H1650 NWDPVFg4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nheWlEPTB;OT62NFk1PiEQvF2= NWm1S3VoW0GQR1XS
NCI-H1563 NWXlT2s1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1T0XGlEPTB;OT63OlA{OSEQvF2= NEDQ[4dUSU6JRWK=
CAL-85-1 NHrTS2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTlwOEezPFMh|ryP M1XjUXNCVkeHUh?=
UM-UC-3 M1PUemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzWXnJqUUN3ME25Mlk2ODNizszN NXXY[|BEW0GQR1XS
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DEL NYfRRow5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULE[ppJUUN3ME2xNE4{QTR4IN88US=> NIrOc3lUSU6JRWK=
HuCCT1 NI\uRm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHFclNKSzVyPUGwMlYxOzNizszN NIfzfZJUSU6JRWK=
OVCAR-4 MnvZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\XRYVKUUN3ME2xNE45QDN3IN88US=> NV7JPFQ2W0GQR1XS
CAL-72 NVuyW5FGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPTZYlKSzVyPUGwMlk{QTFizszN MWrTRW5ITVJ?
HCC1954 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;DWmlEPTB;MUGuNFc2PCEQvF2= NV;OTHRrW0GQR1XS
EFO-21 M3H3[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTFzLkGwOFUh|ryP NWnuTJVXW0GQR1XS
FTC-133 M37iWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrpXpFKSzVyPUGxMlE1ODdizszN MWPTRW5ITVJ?
SK-MEL-24 NV;HdXJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjTTWM2OD1zMT6yN|Y3KM7:TR?= M3XIUHNCVkeHUh?=
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NCI-H650 NF7mV2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDKTWM2OD1zMT6yOFE5KM7:TR?= NVWxPWNiW0GQR1XS
ALL-PO MmS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXL5[INkUUN3ME2xNU4zPTF{IN88US=> NYG3elJ5W0GQR1XS
T84 NXLORZlTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPxcYNKSzVyPUGxMlM6ODdizszN NFzs[VJUSU6JRWK=
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SW626 NFfyUpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfI[YREUUN3ME2xNU42PzV3IN88US=> M{\zRnNCVkeHUh?=
RPMI-2650 MmnmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGX4cJVKSzVyPUGxMlU5QDVizszN NFnldVlUSU6JRWK=
MC-IXC MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTFzLk[3Nlgh|ryP NXHo[5piW0GQR1XS
HOP-62 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HwO2lEPTB;MUGuOlc3PCEQvF2= MXzTRW5ITVJ?
NOS-1 M1PnOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLHOJhKSzVyPUGxMlcyODlizszN NFL3bW9USU6JRWK=
SW1573 MlPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXRTo1KSzVyPUGxMlczQTVizszN NF7ZWYNUSU6JRWK=
WM-115 M1vqNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnu2TWM2OD1zMT63OVg5KM7:TR?= MlHJV2FPT0WU
HuO9 Mof2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvyUGxzUUN3ME2xNU45Pzd2IN88US=> NX7ISnplW0GQR1XS
YAPC NFLhWHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHqRWd7UUN3ME2xNU46OjV7IN88US=> MlPkV2FPT0WU
MDA-MB-453 NFzZc4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTJWGhkUUN3ME2xNU46PTF3IN88US=> MY\TRW5ITVJ?
NCI-H596 NWHUT41YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nBWmlEPTB;MUKuNFM3QSEQvF2= MX7TRW5ITVJ?
A172 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrJTWM2OD1zMj6wO|k5KM7:TR?= MnjKV2FPT0WU
RS4-11 NYfzV3ByT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTF{LkG3NlUh|ryP NWHncpVtW0GQR1XS
HCC1937 MlnkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFz5W|FKSzVyPUGyMlc2PjRizszN M{foU3NCVkeHUh?=
SW837 NYfXcWtJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XHUmlEPTB;MUKuPVAzQCEQvF2= M3i1c3NCVkeHUh?=
NMC-G1 MmnDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rQRmlEPTB;MUKuPVI{PCEQvF2= NXfNOXV{W0GQR1XS
PFSK-1 M4iwWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETvO4VKSzVyPUGzMlA3KM7:TR?= MnvkV2FPT0WU
DBTRG-05MG MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\sSmlEPTB;MUOuNFY{OiEQvF2= MULTRW5ITVJ?
SK-UT-1 M1TK[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEC4UItKSzVyPUGzMlExQDNizszN NFi2SItUSU6JRWK=
OVCAR-5 NITDNnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXJTWM2OD1zMz6xOVk{KM7:TR?= M4HqfHNCVkeHUh?=
8505C NI\FUYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUm1THRuUUN3ME2xN{4zODZ5IN88US=> M1;oeXNCVkeHUh?=
SK-MEL-1 NHf1eXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rUdWlEPTB;MUOuO|E{PSEQvF2= NIHlNJlUSU6JRWK=
LK-2 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHUUFRKSzVyPUGzMlc3OzlizszN MkC5V2FPT0WU
OE33 M1;yXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoT5TWM2OD1zMz63PFYh|ryP MoLHV2FPT0WU
Ramos-2G6-4C10 NH;BS4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HPUGlEPTB;MUSuNFIxOiEQvF2= MoK0V2FPT0WU
EW-13 NGnqWplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvsTWM2OD1zND6wN|UzKM7:TR?= NGTJUG5USU6JRWK=
NCI-H1793 MnzzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rrZmlEPTB;MUSuNlA5PyEQvF2= MYjTRW5ITVJ?
BHT-101 NEPr[HJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTF2LkK0NUDPxE1? Mn\qV2FPT0WU
RKO M{jMeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIL1eXdKSzVyPUG0MlUxPzVizszN M2jzZXNCVkeHUh?=
NEC8 NH:2RZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWH2cog1UUN3ME2xOE42PDd{IN88US=> MnPQV2FPT0WU
PANC-10-05 NI\tOVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTF2Lk[yOFch|ryP MmrwV2FPT0WU
NCI-H2030 MmraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojFTWM2OD1zND62OFQ5KM7:TR?= NVjzdZdXW0GQR1XS
C2BBe1 NHvhdFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHO0fYJKSzVyPUG0Mlc3PCEQvF2= NHPENlBUSU6JRWK=
EM-2 NHvCRXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HWW2lEPTB;MUSuPFU4PiEQvF2= MWXTRW5ITVJ?
HCC1395 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY[1XVFWUUN3ME2xOE46OzN6IN88US=> NXPxXWFNW0GQR1XS
A2058 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HONGlEPTB;MUWuNFQxQSEQvF2= MXnTRW5ITVJ?
SW1463 NF\4TFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnzc3V7UUN3ME2xOU4xPDh3IN88US=> NFHNVJBUSU6JRWK=
J82 M3XIVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkG2TWM2OD1zNT6wOVch|ryP MYXTRW5ITVJ?
CAL-120 Ml3ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTF3LkG0OFch|ryP NXy5XG5tW0GQR1XS
COLO-824 Mn63S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3HTWM2OD1zNT6xOVc6KM7:TR?= NXTuRnRMW0GQR1XS
LNCaP-Clone-FGC NUX2R29yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HqNWlEPTB;MUWuOFI1QCEQvF2= NEHr[4JUSU6JRWK=
CP66-MEL NWOxXnlDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DQeGlEPTB;MUWuOFY5QCEQvF2= MlXTV2FPT0WU
OC-314 NXHiRnpVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7UPGRKSzVyPUG1MlQ4OTRizszN MVjTRW5ITVJ?
OVCAR-8 NF21eVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13OZ2lEPTB;MUWuPFg3OSEQvF2= NXnnRodoW0GQR1XS
MFE-280 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nY[WlEPTB;MU[uNFQ5QCEQvF2= Ml3LV2FPT0WU
MHH-NB-11 NFjWfoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTF4LkC4N|kh|ryP M{HuOnNCVkeHUh?=
SW1990 NV\Td5Y6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPWTWM2OD1zNj6xO|U2KM7:TR?= NGHrRlJUSU6JRWK=
U-266 Mnz4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHQZ5pGUUN3ME2xOk4zOjl7IN88US=> Mm[wV2FPT0WU
MFM-223 NH:zfZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTF4LkO5OlUh|ryP M2HSSXNCVkeHUh?=
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MCF7 NHvud|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TBcWlEPTB;MU[uOFczOyEQvF2= M3fIbnNCVkeHUh?=
SK-MEL-3 NVnyfo9bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XRWWlEPTB;MU[uOFc5PyEQvF2= MlLhV2FPT0WU
HH NX;uNGNLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\ndmlEPTB;MU[uOVE3OiEQvF2= NWjLPIdqW0GQR1XS
no-10 NIT2[mlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{W0dWlEPTB;MU[uOlM1OyEQvF2= MVrTRW5ITVJ?
HuP-T3 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTF4Lk[1O|Yh|ryP MVTTRW5ITVJ?
QIMR-WIL NUDKbVlyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LlVGlEPTB;MU[uO|ExPSEQvF2= MWTTRW5ITVJ?
NCI-H1092 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rPW2lEPTB;MU[uPFMyPiEQvF2= MlPtV2FPT0WU
MZ2-MEL NWrjeldVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\1TWM2OD1zNj64OFA{KM7:TR?= NFHUemJUSU6JRWK=
ES3 M{i0dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;rNHpKSzVyPUG2MlkyOzRizszN M3;yeHNCVkeHUh?=
COLO-684 NFKwVVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rod2lEPTB;MU[uPVQ4PyEQvF2= NYjkRXdHW0GQR1XS
NCI-H661 NFHjWGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVuxOnFRUUN3ME2xOk46Pjl2IN88US=> NI\4T4dUSU6JRWK=
CP50-MEL-B M2DHTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml2wTWM2OD1zNz6wN|Q{KM7:TR?= Mk\1V2FPT0WU
NCI-H2405 NVS4Wmg3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVToTnZyUUN3ME2xO{4yQTd2IN88US=> MnHSV2FPT0WU
U-2-OS MnnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTF5LkWzNFch|ryP MljJV2FPT0WU
RERF-LC-MS NE[2NXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXNTWM2OD1zNz61OVA5KM7:TR?= NYTkZVVGW0GQR1XS
NCI-H2342 NIfQ[IpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPUW|REUUN3ME2xO{42PTdizszN M{mxd3NCVkeHUh?=
ES8 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjjWXhxUUN3ME2xO{43ODh5IN88US=> M33WXHNCVkeHUh?=
MOLT-16 NYrrb5RpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnTfotnUUN3ME2xO{45QTN2IN88US=> MmDFV2FPT0WU
RH-18 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjITWM2OD1zOD6wNFM2KM7:TR?= NYHzPYE{W0GQR1XS
D-283MED NYLEb5RtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1f4W2lEPTB;MUiuNFA5QCEQvF2= M2HwbnNCVkeHUh?=
RCC10RGB NUPGZZpOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTF6LkC1OVkh|ryP NHi3U25USU6JRWK=
NCI-H1437 NFrRSXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIm3eIRKSzVyPUG4MlE3PDFizszN NEnwWFdUSU6JRWK=
SW982 M3;xO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYK3T2JVUUN3ME2xPE4zPjdzIN88US=> MnjlV2FPT0WU
IST-MES1 NEXIWHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlr3TWM2OD1zOD60OFI5KM7:TR?= MkfRV2FPT0WU
A704 MmLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTF6LkS3OVMh|ryP M1\UXnNCVkeHUh?=
ESS-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDRTWM2OD1zOD61NlA2KM7:TR?= MXrTRW5ITVJ?
SCH NFvRR4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo[yTWM2OD1zOD62OFU3KM7:TR?= NVPoe|N{W0GQR1XS
COLO-320-HSR MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfwO2JKSzVyPUG4Mlc1PiEQvF2= NFrkbFVUSU6JRWK=
Mo-T NH7a[oNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2WwNWlEPTB;MUiuPFIxPCEQvF2= MVTTRW5ITVJ?
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22RV1 NUC4V2F6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfRSpp7UUN3ME2zOE4yPzV2IN88US=> NInhb3lUSU6JRWK=
KM-H2 NUT1PI9WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XadGlEPTB;M{SuNVc4QSEQvF2= MV3TRW5ITVJ?
NCI-H2122 NYTsZ4ttT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXP5bWtlUUN3ME2zOE4{PDdzIN88US=> NV;wUXlKW0GQR1XS
ABC-1 NF\yfVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlyxTWM2OD1|ND6zOlk{KM7:TR?= NEPVZYdUSU6JRWK=
NCI-H1355 NHP1N3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDwfGlKSzVyPUO0MlM5QDlizszN MmC0V2FPT0WU
NOMO-1 NVfVe2ZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTN2LkW3NFMh|ryP MWHTRW5ITVJ?
MZ7-mel MlS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nQT2lEPTB;M{SuOlQ5PyEQvF2= MoO4V2FPT0WU
NCI-H810 NW[3To11T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;ETWM2OD1|ND63Nlc5KM7:TR?= NVS4OGF5W0GQR1XS
D-392MG NWfWd4FmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2r5NWlEPTB;M{WuNFU3PSEQvF2= NXu0THdZW0GQR1XS
LB771-HNC M3jXTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\DU2RKSzVyPUO1MlE3PThizszN NYnnZYcxW0GQR1XS
COLO-679 NF[zN|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLxTWM2OD1|NT6zPFgh|ryP NXPRS45IW0GQR1XS
SK-PN-DW MojrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTN3LkSzOlkh|ryP NIP1S5VUSU6JRWK=
VA-ES-BJ NUDUc442T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUG0PXlKUUN3ME2zOU41PjR7IN88US=> MVTTRW5ITVJ?
KNS-42 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13RTmlEPTB;M{WuOVgzPiEQvF2= NVjTdXdxW0GQR1XS
RVH-421 MoHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfw[ZdUUUN3ME2zOU44PjR3IN88US=> NUPsUphmW0GQR1XS
P30-OHK NX\UboRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofPTWM2OD1|NT64O|UzKM7:TR?= NEfnWWtUSU6JRWK=
G-402 M33uPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXr0TnBYUUN3ME2zOU46QDZ5IN88US=> M2\QSXNCVkeHUh?=
S-117 NHvYXYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIH0PGRKSzVyPUO2MlMxODhizszN NGfYfZRUSU6JRWK=
RXF393 M3T4OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDMU3M{UUN3ME2zOk4{Pzh3IN88US=> M2H2XXNCVkeHUh?=
LCLC-103H NXHE[GI2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEH4NYZKSzVyPUO2Mlc5ODNizszN M3ixdnNCVkeHUh?=
U-118-MG NVXEcHkzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzyTWM2OD1|Nj64PFQ4KM7:TR?= NWe1ephRW0GQR1XS
8-MG-BA MkXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXCcIRWUUN3ME2zOk46PDh|IN88US=> MVPTRW5ITVJ?
MFH-ino M373NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjJRYdKSzVyPUO3MlM{PzFizszN NYm3VZByW0GQR1XS
NCI-H23 NGC5UYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPjVnZKSzVyPUO3MlQyQTZizszN NFrpRm9USU6JRWK=
NCI-H446 NWXKVm1RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvUTWM2OD1|Nz60PFYzKM7:TR?= MkTyV2FPT0WU
LU-99A NVTDSJg4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{G3UGlEPTB;M{euOVc{OSEQvF2= NWrP[oxGW0GQR1XS
KP-N-YN Mlr1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrTTWM2OD1|Nz62NVk2KM7:TR?= NULWZ5I{W0GQR1XS
SCC-9 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITH[4dKSzVyPUO3Mlc5OzhizszN M2LDcXNCVkeHUh?=
EFM-19 M1:4Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfyUJVKSzVyPUO3Mlc6PjdizszN MV\TRW5ITVJ?
A427 MkfzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGm3OYdKSzVyPUO3MlkyODdizszN M1z5fXNCVkeHUh?=
LB831-BLC MmPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfWWHVUUUN3ME2zPE43ODN7IN88US=> MnvlV2FPT0WU
HOS MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvCb3NKSzVyPUO5MlYzPzNizszN MYLTRW5ITVJ?
LAN-6 NHfPW3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLvNHNzUUN3ME20NE4xOTF{IN88US=> NWTYfWdMW0GQR1XS
U251 NG\hfIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfpTWM2OD12MD60NFU1KM7:TR?= MVTTRW5ITVJ?
SNU-387 MoDRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jHNmlEPTB;NECuOFU2OyEQvF2= NGTzWWNUSU6JRWK=
DMS-79 MkGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDtVFFVUUN3ME20NE42QDh7IN88US=> NGrMb2RUSU6JRWK=
SK-LU-1 M1\oTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTRyLk[1Olgh|ryP NIrFfJBUSU6JRWK=
HT MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLrTWM2OD12MD62OlM6KM7:TR?= MnrNV2FPT0WU
KP-N-YS NWLK[lBpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2ricGlEPTB;NECuOlc3QCEQvF2= MV3TRW5ITVJ?
DMS-114 NUDvR2NZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2H4[mlEPTB;NECuPFM4PCEQvF2= MXvTRW5ITVJ?
HUTU-80 M3PtPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTRzLkC1Olkh|ryP NVf4eVhOW0GQR1XS
ONS-76 MkDwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PpXmlEPTB;NEGuOFcxQSEQvF2= MVfTRW5ITVJ?
A673 M2XMfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPrNY5FUUN3ME20NU42OTV5IN88US=> MnLjV2FPT0WU
HPAF-II NGnJRpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVryXpRnUUN3ME20NU43PzB7IN88US=> NVPXSI1SW0GQR1XS
UACC-257 NVXsV|FPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PDXmlEPTB;NEGuO|M3QSEQvF2= NYnYRmF5W0GQR1XS
EW-22 NWPDdHlTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTw[GRKSzVyPUSxMlg3QTdizszN MVfTRW5ITVJ?
NCI-H1755 M3jB[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrYWJBKSzVyPUSxMlg4OjVizszN MoLNV2FPT0WU
KYSE-150 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPyRZJlUUN3ME20Nk4yPzh{IN88US=> NUDkSpZnW0GQR1XS
CGTH-W-1 NVvkdIY{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rFWWlEPTB;NEKuOFk2PSEQvF2= M4\YXXNCVkeHUh?=
NB13 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTR{Lk[yNVch|ryP NIPsbYJUSU6JRWK=
SW872 M4PaeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TBRWlEPTB;NEKuOlM{OSEQvF2= NFjxflVUSU6JRWK=
KP-4 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTR{Lki4N|Ih|ryP M1LrS3NCVkeHUh?=
HCC38 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojkTWM2OD12Mj65OlE5KM7:TR?= M132OXNCVkeHUh?=
BB49-HNC M2C1TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTR|LkKzOVYh|ryP MXvTRW5ITVJ?
CAL-62 NVXuWHRVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1n6XGlEPTB;NEOuOFAzQCEQvF2= NInFfYFUSU6JRWK=
NCI-H2029 Mkj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nlXWlEPTB;NEOuOVU5OSEQvF2= M3Tzb3NCVkeHUh?=
M14 M4TCPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjPOm12UUN3ME20OE4yOzN{IN88US=> MXPTRW5ITVJ?
COLO-680N M2XjO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWniUpNUUUN3ME20OE4{OzlizszN MUnTRW5ITVJ?
Hs-578-T NF7o[3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTYUmZKSzVyPUS1MlAzQTRizszN MmS1V2FPT0WU
MSTO-211H NXf6TVQ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlm5TWM2OD12NT65OFgzKM7:TR?= MX\TRW5ITVJ?
EW-1 NV;HfGtrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HGWGlEPTB;NEWuPVY5QSEQvF2= M4LkXnNCVkeHUh?=
SW948 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvSdWRKSzVyPUS2MlQ1PjJizszN MnrWV2FPT0WU
NCI-H460 NWnMcJRtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTR4LkWyN{DPxE1? NGnkVpRUSU6JRWK=
CAS-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vOUmlEPTB;NE[uO|cxOSEQvF2= NGHLXm1USU6JRWK=
TGBC11TKB MlHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTR5LkG3O|ch|ryP MWrTRW5ITVJ?
HD-MY-Z M3;kcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFKyUoJKSzVyPUS4Mlc5PiEQvF2= MkXMV2FPT0WU
NCI-H226 NUHIT5V{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;abIRKSzVyPUS5Mlc4QDVizszN MkXQV2FPT0WU
PA-1 NGnSWYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LpWmlEPTB;NEmuPFM{PSEQvF2= NF7rS4hUSU6JRWK=
LB2518-MEL MmPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3S4fGlEPTB;NEmuPFczOyEQvF2= MmLIV2FPT0WU
A101D NFvqdGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfzTWM2OD12OT65OFI2KM7:TR?= NX\iXIVMW0GQR1XS
NCI-H2087 NX[zfFlIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTR7Lkm2PFIh|ryP MVTTRW5ITVJ?

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
CIP2A / p-AKT / AKT / PARP; 

PubMed: 25537503     


Time-dependent effects of afatinib on CIP2A, p-AKT and apoptosis-related proteins in the sensitive H358 and resistant H460 cells. Cells were exposed to 10 μM afatinib for up to 48 hours. Immunoblots were scanned and quantitated to determine the ratio of the level of CIP2A to actin. Data are mean ± SD. n = 3 for the different time intervals.

p-EGFR / p-IGF1R / p-ERK / p-AKT; 

PubMed: 26052929     


Effects of afatinib on EGFR and IGF1R Signaling Pathways. H1975 cells were treated with afatinib with various doses and cell lysates were subjected to Western blot analysis. Afatinib effectively inhibits p-EGFR and p-ERK while p-AKT was partially inhibited. IGF1R phosphorylation was increased upon afatinib treatment in H1975 cells.

25537503 26052929
Growth inhibition assay
Cell apoptosis; 

PubMed: 25537503     


Dose-dependent effects of afatinib on apoptosis. Data are mean ± SD. n = 3 for each concentration. *, p < 0.05, **, p < 0.01, vs. no afatinib. 

Cell viability; 

PubMed: 26515464     


A. MTS assay for Ba/F3 cells harboring EGFR exon 19 deletion and L858R. The proportional cell viability is shown. B. MTS assay for Ba/F3 cells harboring EGFR exon 19 deletion+T790M and L858R+T790M. The proportional cell viability is shown. C. MTS assay for Ba/F3 cells harboring wild type EGFR. The proportional cell viability is shown. Erlotinib, afatinib, osimertinib, and rociletinib were used as EGFR-TKIs. Error bars indicate standard deviation.

25537503 26515464
Immunofluorescence
p65; 

PubMed: 26317651     


Effects of different treatments on the nuclear translocation of the NF-κB subunit p65. A2780T cells were treated with 2.5 μM afatinib for 48 hours, or 10 μM PDTC for 2 hours. Subsequently, the NF-κB subunit p65 (red) was localized by immunofluorescence and a confocal microscopy. Nuclei were stained with DAPI (blue). Scale bar = 10 μM.

vacuoles; 

PubMed: 29713246     


Autophagy activation upon treatment with Afatinib and Sorafenib was validated using immunofluorescence in order to visualize a creation of autophagosomes; ×60 magnification. DMSO treatment was used as control. Green—autophagy vacuoles; Blue—Hoechst, nuclear staining. 

26317651 29713246
体内研究 活体研究时按实验对象体重,每千克口服20 mg BIBW2992持续25天,肿瘤产生明显的衰退现象,通过肿瘤切片的免疫组织化学染色观察发现,EGFR和AKT的磷酸化作用收到抑制。因此,正如lapatinib和neratinib, BIBW2992是次代酪氨酸激酶抑制剂,不可逆地抑制人类EGFR2(HER2)和EGFR激酶。BIBW2992不仅能和原代酪氨酸激酶如erlotinib和gefitinib一样有效抑制EGFR突变型,而且还能作用于抗erlotinib和gefitinib的EGFR。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

+ 展开

体外激酶活性实验:

人类EGFR和L858R/T790M双重突变型EGFR 的酪氨酸激酶区域与谷胱甘肽巯基转移酶区域相接,提取酪氨酸激酶区域的方法见补充说明。在有和没有BIBW2992时分别测定酶活。使用杆状病毒系统克隆HER2激酶,用类似提取EGFR激酶域的方法提取HER2激酶域。
细胞实验:

[1]

+ 展开
  • Cell lines: NSCLC细胞
  • Concentrations: 0-10 μM
  • Incubation Time: 1小时
  • Method:

    细胞按1×104密度转移到96孔板上,在无血清培养基上过夜培养,用于EGFR磷酸化实验。第二天添加包含BIBW2992的混合物,培养基在37oC温育1小时。在室温下用100 ng/ml EGF刺激10分钟。细胞用冰冻PBS冲洗,然后每孔用120 μl HEPEX buffer萃取,然后在室温下震荡1小时。每孔中所有2×104细胞都用于HER2磷酸化实验。在涂有链霉亲和素的板上加用封闭液按1:100比例稀释的抗EGFR的生物素和c-erb2/HER2肿瘤蛋白Ab-5-生物素。上述步骤得到的萃取物转移到有抗体包被的孔中,室温下温育1小时。彩色显影的测法见补充说明,吸光度为450纳米。


    (Only for Reference)
动物实验:

[1]

+ 展开
  • Animal Models: 雌性无胸腺NMRI-nu/nu鼠
  • Formulation: 0.5%甲基纤维素-0.4% Tween-80
  • Dosages: 20 mg/kg
  • Administration: 口服处理
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 97 mg/mL (199.61 mM)
Ethanol 15 mg/mL (30.86 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
10mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 485.94
化学式

C24H25ClFN5O3

CAS号 439081-18-2
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03878524 Not yet recruiting Breast Cancer|Prostate Cancer|Pancreatic Cancer|Acute Myelogenous Leukemia OHSU Knight Cancer Institute|Oregon Health and Science University|Prospect Creek Foundation March 14 2019 Phase 1
NCT03878524 Not yet recruiting Breast Cancer|Prostate Cancer|Pancreatic Cancer|Acute Myelogenous Leukemia OHSU Knight Cancer Institute|Oregon Health and Science University|Prospect Creek Foundation March 14 2019 Phase 1
NCT03827070 Recruiting Non Small Cell Lung Cancer Center Trials & Treatment Europe|Center Trials & Treatment March 5 2019 Phase 1
NCT03827070 Recruiting Non Small Cell Lung Cancer Center Trials & Treatment Europe|Center Trials & Treatment March 5 2019 Phase 1
NCT03727724 Active not recruiting Carcinoma Non-Small-Cell Lung The Netherlands Cancer Institute|Boehringer Ingelheim|Merck Serono International SA December 4 2018 Phase 2
NCT03727724 Active not recruiting Carcinoma Non-Small-Cell Lung The Netherlands Cancer Institute|Boehringer Ingelheim|Merck Serono International SA December 4 2018 Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • 回答:

    For in vivo experiment of afatinib, we recommend 0.5% methylcellulose/0.2% Tween 80 as vehicle.

EGFR Signaling Pathway Map

EGFR Inhibitors with Unique Features

相关EGFR产品

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID