Afatinib (BIBW2992)

For research use only. Not for use in humans.

目录号:S1011

Afatinib (BIBW2992) Chemical Structure

Molecular Weight(MW): 485.94

Afatinib (BIBW2992) 不可逆地抑制EGFR/ErbB,包括EGFR(wt)EGFR(L858R),EGFR(L858R/T790M),ErbB2(HER2)和ErbB4(HER4),在无细胞试验中IC50分别为0.5 nM,0.4 nM,10 nM,14 nM和1 nM。Afatinib可诱导自噬。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1964.25 现货
RMB 977.68 现货
RMB 1724.11 现货
RMB 3087.63 现货
RMB 4652.69 现货
RMB 10401.3 现货
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客户使用Selleck生产的Afatinib (BIBW2992)发表文献202篇:

产品安全说明书

EGFR抑制剂选择性比较

生物活性

产品描述 Afatinib (BIBW2992) 不可逆地抑制EGFR/ErbB,包括EGFR(wt)EGFR(L858R),EGFR(L858R/T790M),ErbB2(HER2)和ErbB4(HER4),在无细胞试验中IC50分别为0.5 nM,0.4 nM,10 nM,14 nM和1 nM。Afatinib可诱导自噬。
靶点
EGFR (L858R) [1]
(Cell-free assay)
EGFR (wt) [1]
(Cell-free assay)
ErbB4 [2]
(Cell-free assay)
EGFR (L858R/T790M) [1]
(Cell-free assay)
HER2 [1]
(Cell-free assay)
0.4 nM 0.5 nM 1 nM 10 nM 14 nM
体外研究

BIBW2992不可逆地抑制EGFR/HER2,在体外作用于野生型EGFR ,L858R突变型EGFR, L858R/T790M 双突变型EGFR,及HER2时IC50分别为0.5, 0.4, 10, 14 nM。在体外实验中,BIBW2992不管作用于野生型EGFR/HER2还是突变型EGFR/HER2都显示出强大的活力,与gefitinib作用于L858R突变型EGFR的活力差不多,但是要比gefitinib 作用于L858R-T790M双突变型EGFR的活力大100倍。在体外,BIBW2992有效抑制所有实验类型细胞的EGFR/HER磷酸化作用。比如人类扁平上皮癌A431细胞系表达的野生型EGFR, 鼠类NIH-3T3细胞转染的野生型HER2 , 以及乳腺癌BT-474细胞系和胃癌NCI-N87细胞系表达的内源性HER2。[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HDLM-2 NXHqNY5yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTBwMEC1O|Ih|ryP M{fZenNCVkeHUh?=
KASUMI-1 NVG2WpBOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PjXWlEPTB;MD6wNFkyOSEQvF2= MWjTRW5ITVJ?
HCC2218 NFTCWlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo[5TWM2OD1yLkCwPVg4KM7:TR?= M1HCZnNCVkeHUh?=
KARPAS-45 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVX3fFVVUUN3ME2wMlAyPjdzIN88US=> NEfZ[2FUSU6JRWK=
HSC-4 M4i3WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;MTWM2OD1yLkCxO|Q5KM7:TR?= NFHiWZZUSU6JRWK=
CHL-1 MoTVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPuTWM2OD1yLkCxPFM6KM7:TR?= NVnnSFcxW0GQR1XS
KY821 MoW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmS2TWM2OD1yLkCyNFYh|ryP NFvRUlRUSU6JRWK=
NCI-N87 NEfXNXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfzb2xkUUN3ME2wMlAzPzd|IN88US=> NF\NeZpUSU6JRWK=
DOK Mo\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrHOJBKSzVyPUCuNFMyQTRizszN MoDYV2FPT0WU
DSH1 MnTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTBwMEOzNVQh|ryP M3j4NnNCVkeHUh?=
MDA-MB-175-VII NHzYSYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV[5fXo2UUN3ME2wMlA{PDF4IN88US=> MUPTRW5ITVJ?
NCI-H2170 MnH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rmRmlEPTB;MD6wN|czQCEQvF2= M3ra[HNCVkeHUh?=
BT-474 Mm\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWX2SYhGUUN3ME2wMlA1QTh4IN88US=> NVHBNYFtW0GQR1XS
EFO-27 MkXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTBwMEWxPFIh|ryP Mn;jV2FPT0WU
NCI-H720 M1;yVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnn0TWM2OD1yLkC1N|I2KM7:TR?= NIj5cVZUSU6JRWK=
PC-14 NETlWFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jzXmlEPTB;MD6wOVY3QCEQvF2= M4PqcnNCVkeHUh?=
EC-GI-10 M2ft[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M170cmlEPTB;MD6wOVkyOiEQvF2= M3LqfHNCVkeHUh?=
KYSE-450 MnT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVj3dZAyUUN3ME2wMlA2QTd6IN88US=> M2XGPXNCVkeHUh?=
BPH-1 NFLOepJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwMEW5PFgh|ryP NYG5cWw3W0GQR1XS
NCI-H292 NHXhO4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;MeJJKSzVyPUCuNFYxQSEQvF2= MlPUV2FPT0WU
H9 MkHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlz6TWM2OD1yLkC3NVMzKM7:TR?= NHi5R3RUSU6JRWK=
NCI-H526 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnlTWM2OD1yLkC3PFI{KM7:TR?= MXTTRW5ITVJ?
NCI-H1623 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwMEiwNlUh|ryP MkPqV2FPT0WU
KYSE-140 NGfCOWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTBwMEizN{DPxE1? NUnlXFFQW0GQR1XS
Ca9-22 MkXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLUTWM2OD1yLkC4N|U{KM7:TR?= NF\ZZohUSU6JRWK=
AU565 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWCwdVN2UUN3ME2wMlA5PTB2IN88US=> NF6wWYZUSU6JRWK=
ZR-75-30 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwMEm1OFUh|ryP NUHoS4c1W0GQR1XS
NCI-H1770 MofPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjV[ZlsUUN3ME2wMlExOjhizszN NHHV[nBUSU6JRWK=
LB2241-RCC Mkn1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2i1U2lEPTB;MD6xNFg5PCEQvF2= NGqzTZFUSU6JRWK=
CAL-39 M4TwXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3QV4pKSzVyPUCuNVE4QTJizszN MkiyV2FPT0WU
UACC-893 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwMUG4PFUh|ryP M1rNO3NCVkeHUh?=
LU-65 M2[3XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV61WIxVUUN3ME2wMlEzPjN|IN88US=> NUSxZ3JJW0GQR1XS
HN MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLHTWM2OD1yLkGzNFc4KM7:TR?= NUC2cnFzW0GQR1XS
TI-73 NFPkNHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTBwMUS3NVUh|ryP MlLJV2FPT0WU
KU812 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnG0TWM2OD1yLkG1OFU3KM7:TR?= NFvt[mtUSU6JRWK=
SW13 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn23TWM2OD1yLkG2NlE3KM7:TR?= NVfSUopwW0GQR1XS
BB30-HNC NH7idIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXWxcFNQUUN3ME2wMlE3PTd4IN88US=> NFfSOpZUSU6JRWK=
HSC-2 NYrRdHVNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTBwMU[4N|ch|ryP NWi2TJhuW0GQR1XS
BV-173 NG\2XJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzTTWM2OD1yLkG3OVk3KM7:TR?= NVHwO|BXW0GQR1XS
CAL-27 M3i2cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33RR2lEPTB;MD6xO|Y{PiEQvF2= M1fJTnNCVkeHUh?=
SBC-1 MkTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUX4OG03UUN3ME2wMlE5QTV7IN88US=> MnzUV2FPT0WU
CAL-33 MmT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGryemlKSzVyPUCuNlAyQDRizszN MX7TRW5ITVJ?
NCI-H209 MkK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYiwVHFXUUN3ME2wMlIxPDZizszN M3vEUnNCVkeHUh?=
COR-L105 MnToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLvbHFxUUN3ME2wMlIyODh2IN88US=> NELrXnNUSU6JRWK=
HSC-3 M1jzTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTmfINxUUN3ME2wMlIyOTl6IN88US=> NX7nUGROW0GQR1XS
NCI-H69 NYPoVZhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwMkG0OVEh|ryP MnjHV2FPT0WU
MOLT-13 MkP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PxZmlEPTB;MD6yN|k4PSEQvF2= NF2wZnVUSU6JRWK=
ML-2 NEHq[VNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvxcXByUUN3ME2wMlI1QDB{IN88US=> MoXjV2FPT0WU
IGROV-1 M1vDVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrjXZBKSzVyPUCuNlU6PTJizszN M{C3[XNCVkeHUh?=
TK10 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjFTWM2OD1yLkK2O|M5KM7:TR?= NIHHSoVUSU6JRWK=
EoL-1-cell NEjHNnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwMk[4PVIh|ryP NYfhZXFwW0GQR1XS
HO-1-N-1 M2LlUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYqzdJQ1UUN3ME2wMlI4QDV|IN88US=> M3f6ZnNCVkeHUh?=
BHY NFKwcnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwMki2OVUh|ryP NXrxNW1IW0GQR1XS
LU-139 NGXGclBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLRTWM2OD1yLkOwOVEh|ryP NXXhSGdbW0GQR1XS
23132-87 MlHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LsfmlEPTB;MD6zNVkzOyEQvF2= MkXnV2FPT0WU
ACHN NW[4NIZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlGxTWM2OD1yLkOxPVk1KM7:TR?= Ml7GV2FPT0WU
DoTc2-4510 MlnLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHq3[WlKSzVyPUCuN|IzOTlizszN NGPCb5RUSU6JRWK=
BB65-RCC NWjKb4NGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3kTlZMUUN3ME2wMlM1PTl|IN88US=> M1LqfnNCVkeHUh?=
HLE NFjEcmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWf4em9pUUN3ME2wMlM2ODR4IN88US=> MWXTRW5ITVJ?
HCC1419 M1vENGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwM{[0NFgh|ryP MmjpV2FPT0WU
A388 Mn;yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLWTWM2OD1yLkO2PFU4KM7:TR?= NYfPZ3lkW0GQR1XS
NUGC-3 NVXuTmtxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwM{izO|Mh|ryP NXjSNoR7W0GQR1XS
KYSE-180 M{nzUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDPTWM2OD1yLkO5NFg6KM7:TR?= NHTqbodUSU6JRWK=
TE-6 M3LacGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTUTHZKSzVyPUCuOFAzPDZizszN MYrTRW5ITVJ?
A498 M2\SbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvEfW5PUUN3ME2wMlQxPjd2IN88US=> NXPT[|VwW0GQR1XS
NCI-H1648 M2nHbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYT0b5h[UUN3ME2wMlQ1OTh{IN88US=> MofyV2FPT0WU
DU-145 NGHvW4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnTeY9JUUN3ME2wMlQ1QDN|IN88US=> NHfWdIJUSU6JRWK=
CW-2 MnPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3XT4dKSzVyPUCuOFY6OTRizszN M1vMc3NCVkeHUh?=
A431 MlvBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vhNWlEPTB;MD60PFI{OyEQvF2= M4PsO3NCVkeHUh?=
SAS NUPLO5c2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfuNpdKSzVyPUCuOFg{QThizszN NXv2R4x1W0GQR1XS
NCI-H2126 NEn2WFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\FWWNoUUN3ME2wMlUyQTJ4IN88US=> MoPzV2FPT0WU
NCI-H358 NXfoWGQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXZ[W1KSzVyPUCuOVMzOSEQvF2= NEnEcWpUSU6JRWK=
FADU M4L2VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LCNWlEPTB;MD61OFQxPCEQvF2= Ml6yV2FPT0WU
ACN NHv2PW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTBwNUWwPVQh|ryP MV7TRW5ITVJ?
HCC70 NYT1[oI4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwNUe2OlEh|ryP MXTTRW5ITVJ?
NCI-H1838 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkD1TWM2OD1yLk[wNlk6KM7:TR?= MVfTRW5ITVJ?
CAL-54 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3BdHRKSzVyPUCuOlE3OjFizszN M{T6WnNCVkeHUh?=
NCI-H1975 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\MUGlEPTB;MD62NVczQCEQvF2= MWrTRW5ITVJ?
COR-L88 M1LPOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTBwNkSxNVMh|ryP MXzTRW5ITVJ?
CTV-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTBwNkSzPVIh|ryP NVvxOGdmW0GQR1XS
EW-18 M{X0b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LYcGlEPTB;MD62PFY6QCEQvF2= M174eHNCVkeHUh?=
HCC1806 MoL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTBwNkm2OlYh|ryP MlPzV2FPT0WU
HuP-T4 NXH1OGp{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzUTGRKSzVyPUCuOlk4PiEQvF2= NGnweVNUSU6JRWK=
MDA-MB-361 M3vCVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHSxR5ZKSzVyPUCuO|I3PjJizszN M1XLVHNCVkeHUh?=
NCI-H1573 NVjpXWVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HTT2lEPTB;MD63N|Y{KM7:TR?= MYXTRW5ITVJ?
KU-19-19 MmnqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLkNJNKSzVyPUCuO|c1PjRizszN NFe0dYFUSU6JRWK=
COLO-678 NG[4UopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYSzUYJjUUN3ME2wMlgxQDN2IN88US=> M3;vb3NCVkeHUh?=
C-33-A M{Hk[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3lWFBnUUN3ME2wMlgyOjl5IN88US=> M1LYdHNCVkeHUh?=
Calu-3 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1K0U2lEPTB;MD64NVQ{PCEQvF2= NVrxPFU2W0GQR1XS
AGS NIDrfIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TzWmlEPTB;MD64N|Y1QCEQvF2= MkLDV2FPT0WU
SCC-25 MkD5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTBwOESxO|Eh|ryP NYm5NG5yW0GQR1XS
JVM-2 NF[xbHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3DeHdmUUN3ME2wMlg5Ojl7IN88US=> MYHTRW5ITVJ?
HCE-T MmPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LwfmlEPTB;MD64PFQzQCEQvF2= M3G0fHNCVkeHUh?=
ES4 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnVd3pKSzVyPUCuPVc5OzZizszN NXPHfXp5W0GQR1XS
EKVX NV71NmRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFr1N2tKSzVyPUGuNFExPjRizszN M{HY[XNCVkeHUh?=
D-542MG NFziSpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTFwMEGwOlQh|ryP MXfTRW5ITVJ?
SW1116 M4f3NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDuTWM2OD1zLkCxNlg4KM7:TR?= NVvON4NYW0GQR1XS
5637 NYjXXWpGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknuTWM2OD1zLkCxOVEh|ryP Mnu1V2FPT0WU
HT-1376 NVvUbJBHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\5OmNCUUN3ME2xMlAyPTF|IN88US=> NWPlclNSW0GQR1XS
NB69 NH;5eIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\YTWM2OD1zLkCyPVQ2KM7:TR?= NHL3TXZUSU6JRWK=
YKG-1 NXKx[VRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTFwMEW0NVkh|ryP Mn7YV2FPT0WU
EW-3 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTFwMEe4PFMh|ryP NHL5WYJUSU6JRWK=
GCIY MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MomyTWM2OD1zLkC4NVA1KM7:TR?= NYfIOohRW0GQR1XS
SK-MES-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DjXmlEPTB;MT6xNVQ5PyEQvF2= M2LXT3NCVkeHUh?=
PANC-08-13 MoLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M124PGlEPTB;MT6xOlQyPiEQvF2= MX3TRW5ITVJ?
SK-NEP-1 MoDXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fZcmlEPTB;MT6xO|UyOyEQvF2= M1fleXNCVkeHUh?=
SW954 MmnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDXNIlKSzVyPUGuNlAzOTRizszN Mmr5V2FPT0WU
NCI-SNU-5 M4DEXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrvPHVKSzVyPUGuNlM6KM7:TR?= NVzRPJZsW0GQR1XS
SW48 NF7kN21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M32xO2lEPTB;MT6yOVQ{OiEQvF2= MXLTRW5ITVJ?
HT-3 NGHDXWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTFwMki3OVMh|ryP M1P1ZnNCVkeHUh?=
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JVM-3 NITaNlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTdwOEm1PVkh|ryP MU\TRW5ITVJ?
OAW-28 NHu5e4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTdwOUS1O|gh|ryP MXfTRW5ITVJ?
KURAMOCHI MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnlTWM2OD15Lkm0PFEyKM7:TR?= NVfscoFRW0GQR1XS
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VMRC-RCZ M4Kzcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NECzcY9KSzVyPUiuNFE3QTdizszN NFrPfnBUSU6JRWK=
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D-502MG NY\DXFZUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjFWGpFUUN3ME24MlI6Ojh{IN88US=> MmTQV2FPT0WU
NCI-H1993 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGe4OGJKSzVyPUiuN|M3OzFizszN MUnTRW5ITVJ?
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HAL-01 NEXX[25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\uTWM2OD16LkWxPVEh|ryP M3r4[nNCVkeHUh?=
GT3TKB NXi3TFBMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HofGlEPTB;OD62O|k3PCEQvF2= MnXsV2FPT0WU
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COLO-829 NUf5[o5VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRThwOEC5O|Yh|ryP M1;DTHNCVkeHUh?=
OCI-AML2 Mn3KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1npTWlEPTB;OD65OVQ5OSEQvF2= MX7TRW5ITVJ?
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BFTC-909 NEDY[2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoS0TWM2OD17LkC2O|k6KM7:TR?= NVW1UpBjW0GQR1XS
EW-11 NIrQ[ZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7ZVnVKSzVyPUmuNVc3PTNizszN NHnvcHBUSU6JRWK=
HCE-4 NG\F[ndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTlwMkG1OVgh|ryP NFXJV4ZUSU6JRWK=
BALL-1 M{TSTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XpTmlEPTB;OT6yNVkxPyEQvF2= M2L1XXNCVkeHUh?=
SF539 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEm4TG5KSzVyPUmuNlM2PjJizszN NXiwWmNrW0GQR1XS
CAMA-1 MkHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vQOWlEPTB;OT6yPFEzQCEQvF2= MX;TRW5ITVJ?
C32 M3v0bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\yd2lEPTB;OT6zN|A3PCEQvF2= NIjnVW5USU6JRWK=
NCI-H1703 NWDZU5VxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\UTWM2OD17LkO0N|c2KM7:TR?= M4j2OHNCVkeHUh?=
NCI-H1650 M1zEb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTlwNkC5OFYh|ryP NUnOVmN5W0GQR1XS
NCI-H1563 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrQ[VZLUUN3ME25Mlc3ODNzIN88US=> NEPrVlZUSU6JRWK=
CAL-85-1 NF;wUVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETJS4NKSzVyPUmuPFc{QDNizszN NXr6OZVlW0GQR1XS
UM-UC-3 NGnyfo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXreY0xUUN3ME25Mlk2ODNizszN NWqxVWVGW0GQR1XS
BxPC-3 M1HWbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGmy[lZKSzVyPUGwMlA6PzJizszN NIDKc2lUSU6JRWK=
MHH-PREB-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTFyLkG5PVkh|ryP MYnTRW5ITVJ?
DEL NXf6WZFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzzeJEzUUN3ME2xNE4{QTR4IN88US=> MoPXV2FPT0WU
HuCCT1 NVPz[ndkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvuTWM2OD1zMD62NFM{KM7:TR?= M{XuUXNCVkeHUh?=
OVCAR-4 NX;rVZN3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fHW2lEPTB;MUCuPFg{PSEQvF2= NWPONGJuW0GQR1XS
CAL-72 Ml7TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TiU2lEPTB;MUCuPVM6OSEQvF2= M4e3PHNCVkeHUh?=
HCC1954 NV23[XNlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUX5W28yUUN3ME2xNU4xPzV2IN88US=> MUfTRW5ITVJ?
EFO-21 NVvuTIFsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF[zb4RKSzVyPUGxMlExPDVizszN M1HIe3NCVkeHUh?=
FTC-133 MnPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTFzLkG0NFch|ryP MkXxV2FPT0WU
SK-MEL-24 NEK3VpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorCTWM2OD1zMT6yN|Y3KM7:TR?= M{S0PXNCVkeHUh?=
UACC-62 NEOw[lRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTFzLkKzOlgh|ryP NHPZNWJUSU6JRWK=
NCI-H650 NVL0fXVIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLKZ2M2UUN3ME2xNU4zPDF6IN88US=> MoPsV2FPT0WU
ALL-PO MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\wTWM2OD1zMT6yOVEzKM7:TR?= M2LBcnNCVkeHUh?=
T84 Mlr4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX74c3FYUUN3ME2xNU4{QTB5IN88US=> MXPTRW5ITVJ?
IST-MEL1 NETkeGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1e3T2lEPTB;MUGuOFU2QSEQvF2= NH60PYRUSU6JRWK=
SW626 NHfI[5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIqwWVFKSzVyPUGxMlU4PTVizszN NVTBXZpFW0GQR1XS
RPMI-2650 M1LoRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTFzLkW4PFUh|ryP M{e4dHNCVkeHUh?=
MC-IXC NV7QcHJGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{f1O2lEPTB;MUGuOlczQCEQvF2= NFP3R2RUSU6JRWK=
HOP-62 MlS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\pTWM2OD1zMT62O|Y1KM7:TR?= MnnwV2FPT0WU
NOS-1 NFK1PXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnPUY1KSzVyPUGxMlcyODlizszN Mm\DV2FPT0WU
SW1573 NYq4NolMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PQ[2lEPTB;MUGuO|I6PSEQvF2= MnL3V2FPT0WU
WM-115 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGG1c|NKSzVyPUGxMlc2QDhizszN NF;Y[GhUSU6JRWK=
HuO9 NFzIcWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTMbpJFUUN3ME2xNU45Pzd2IN88US=> MortV2FPT0WU
YAPC MnywS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTFzLkmyOVkh|ryP MYrTRW5ITVJ?
MDA-MB-453 M4jqPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETnTJVKSzVyPUGxMlk2OTVizszN MWXTRW5ITVJ?
NCI-H596 NYHqZVJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTF{LkCzOlkh|ryP MnfrV2FPT0WU
A172 NITpUJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7ocoNKSzVyPUGyMlA4QThizszN NWfJSlk3W0GQR1XS
RS4-11 NETsdnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DzW2lEPTB;MUKuNVczPSEQvF2= MY\TRW5ITVJ?
HCC1937 NUHNOmtXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfOTWM2OD1zMj63OVY1KM7:TR?= M4fxVHNCVkeHUh?=
SW837 M33nT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX72ToV1UUN3ME2xNk46ODJ6IN88US=> M1fISXNCVkeHUh?=
NMC-G1 M4TXPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjvTWM2OD1zMj65NlM1KM7:TR?= NGPObY9USU6JRWK=
PFSK-1 NFS3c45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljMTWM2OD1zMz6wOkDPxE1? NGj5[YhUSU6JRWK=
DBTRG-05MG MnH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTF|LkC2N|Ih|ryP MofUV2FPT0WU
SK-UT-1 M1ryfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXvTWM2OD1zMz6xNFg{KM7:TR?= MnjvV2FPT0WU
OVCAR-5 M1LGZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPnTWM2OD1zMz6xOVk{KM7:TR?= MmrHV2FPT0WU
8505C M3zoRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTF|LkKwOlch|ryP NXTkPFRJW0GQR1XS
SK-MEL-1 NFLndGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWX5boVqUUN3ME2xN{44OTN3IN88US=> M2PubXNCVkeHUh?=
LK-2 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrMOW9iUUN3ME2xN{44PjN7IN88US=> NH\SXZVUSU6JRWK=
OE33 MljFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLHUlNIUUN3ME2xN{44QDZizszN NGLjVIpUSU6JRWK=
Ramos-2G6-4C10 Mlm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHHTWM2OD1zND6wNlAzKM7:TR?= NYX2NVRxW0GQR1XS
EW-13 NXXYZ48xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTHTWM2OD1zND6wN|UzKM7:TR?= MkD0V2FPT0WU
NCI-H1793 M2XBTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPMTWM2OD1zND6yNFg4KM7:TR?= NWq3R2NUW0GQR1XS
BHT-101 NXT2dJlNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofWTWM2OD1zND6yOFEh|ryP M1jCbHNCVkeHUh?=
RKO NUW4U2l2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7QTpU6UUN3ME2xOE42ODd3IN88US=> MXLTRW5ITVJ?
NEC8 Mo\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHXTWM2OD1zND61OFczKM7:TR?= MoDiV2FPT0WU
PANC-10-05 M2\4UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7aTI5KSzVyPUG0MlYzPDdizszN M{W1WXNCVkeHUh?=
NCI-H2030 M3;Tb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDmTWM2OD1zND62OFQ5KM7:TR?= MoXaV2FPT0WU
C2BBe1 M3H6VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjRVXZKSzVyPUG0Mlc3PCEQvF2= NGPDW2VUSU6JRWK=
EM-2 NXXE[mZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\KeFZtUUN3ME2xOE45PTd4IN88US=> MWLTRW5ITVJ?
HCC1395 NHHmeGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTF2LkmzN|gh|ryP NF7iNFdUSU6JRWK=
A2058 NYfiO4RuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTF3LkC0NFkh|ryP M1\1TXNCVkeHUh?=
SW1463 Mmn3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fmZ2lEPTB;MUWuNFQ5PSEQvF2= MlzUV2FPT0WU
J82 M1O2cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTBR4pEUUN3ME2xOU4xPTdizszN MnzhV2FPT0WU
CAL-120 MkXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1K3PGlEPTB;MUWuNVQ1PyEQvF2= NHzpVWFUSU6JRWK=
COLO-824 M1z0RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTF3LkG1O|kh|ryP M{HvTnNCVkeHUh?=
LNCaP-Clone-FGC MofJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTF3LkSyOFgh|ryP NVyzS|hiW0GQR1XS
CP66-MEL NVrrNVlNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrGT|lwUUN3ME2xOU41Pjh6IN88US=> Mmn3V2FPT0WU
OC-314 NHPEdHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTJVphNUUN3ME2xOU41PzF2IN88US=> Mn6yV2FPT0WU
OVCAR-8 Mn76S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHCTWM2OD1zNT64PFYyKM7:TR?= MUfTRW5ITVJ?
MFE-280 NYC3XVZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4G3XWlEPTB;MU[uNFQ5QCEQvF2= NELycHlUSU6JRWK=
MHH-NB-11 M3jhZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTJTWM2OD1zNj6wPFM6KM7:TR?= NIfmTHpUSU6JRWK=
SW1990 M{nwcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWf0N|RrUUN3ME2xOk4yPzV3IN88US=> M4jkOnNCVkeHUh?=
U-266 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTF4LkKyPVkh|ryP M1rrW3NCVkeHUh?=
MFM-223 NWTKd4FlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm[3TWM2OD1zNj6zPVY2KM7:TR?= MXjTRW5ITVJ?
L-363 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPuTWM2OD1zNj60OVc4KM7:TR?= M{izd3NCVkeHUh?=
MCF7 M{jQfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXvTWM2OD1zNj60O|I{KM7:TR?= NF\pbGRUSU6JRWK=
SK-MEL-3 NVPiOGlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorOTWM2OD1zNj60O|g4KM7:TR?= MXTTRW5ITVJ?
HH MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTlUHNKSzVyPUG2MlUyPjJizszN MVLTRW5ITVJ?
no-10 NGK3Z5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXnSo9KSzVyPUG2MlY{PDNizszN MmTnV2FPT0WU
HuP-T3 M1;ZN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfOOWJkUUN3ME2xOk43PTd4IN88US=> M3TJTnNCVkeHUh?=
QIMR-WIL NYewR5hWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXn1T|FOUUN3ME2xOk44OTB3IN88US=> NUP1WpdWW0GQR1XS
NCI-H1092 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITRRlVKSzVyPUG2Mlg{OTZizszN Mn\5V2FPT0WU
MZ2-MEL MkHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HKWGlEPTB;MU[uPFQxOyEQvF2= NYfQWHB1W0GQR1XS
ES3 NWTzNmRxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DwZmlEPTB;MU[uPVE{PCEQvF2= M37nWnNCVkeHUh?=
COLO-684 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEC3S4VKSzVyPUG2Mlk1PzdizszN NV\sRndnW0GQR1XS
NCI-H661 NGTZcFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7zTWM2OD1zNj65Olk1KM7:TR?= NUfLXnY3W0GQR1XS
CP50-MEL-B NEOxOFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrxTWM2OD1zNz6wN|Q{KM7:TR?= NYP5ZZQ2W0GQR1XS
NCI-H2405 M3Xj[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDnfoRKSzVyPUG3MlE6PzRizszN NEnZXHFUSU6JRWK=
U-2-OS MmXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTF5LkWzNFch|ryP NVW0PXFiW0GQR1XS
RERF-LC-MS NXHaOXRMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfi[W1KSzVyPUG3MlU2ODhizszN MlG3V2FPT0WU
NCI-H2342 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTF5LkW1O{DPxE1? NUXZblFyW0GQR1XS
ES8 NEX1PGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWD3[XhbUUN3ME2xO{43ODh5IN88US=> NX6wbZR6W0GQR1XS
MOLT-16 NGHsVGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHnS291UUN3ME2xO{45QTN2IN88US=> Mnj4V2FPT0WU
RH-18 M4X5Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rMNGlEPTB;MUiuNFA{PSEQvF2= MXzTRW5ITVJ?
D-283MED NIHOZodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3kflNEUUN3ME2xPE4xODh6IN88US=> MnL2V2FPT0WU
RCC10RGB NHH1eZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DmPGlEPTB;MUiuNFU2QSEQvF2= M17OWHNCVkeHUh?=
NCI-H1437 MnTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTF6LkG2OFEh|ryP M3vLW3NCVkeHUh?=
SW982 NHLQPXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HpbWlEPTB;MUiuNlY4OSEQvF2= MVvTRW5ITVJ?
IST-MES1 NVPZS492T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTF6LkS0Nlgh|ryP MmHiV2FPT0WU
A704 Mkf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\pTWM2OD1zOD60O|U{KM7:TR?= MXHTRW5ITVJ?
ESS-1 MmnTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnlRXpxUUN3ME2xPE42OjB3IN88US=> NXjrSZh1W0GQR1XS
SCH M3fmRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\xeWlEPTB;MUiuOlQ2PiEQvF2= MVzTRW5ITVJ?
COLO-320-HSR NVzsOWxbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3sfmNKSzVyPUG4Mlc1PiEQvF2= NU\FcJNGW0GQR1XS
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KM-H2 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;XZ4FKSzVyPUO0MlE4PzlizszN MnzpV2FPT0WU
NCI-H2122 NXL5bmhtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPLRXhKSzVyPUO0MlM1PzFizszN NXq2XmpZW0GQR1XS
ABC-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX:3cW9jUUN3ME2zOE4{Pjl|IN88US=> NGPGW3dUSU6JRWK=
NCI-H1355 M3HkPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTN2LkO4PFkh|ryP M{LienNCVkeHUh?=
NOMO-1 NWD5XY1qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLRNVRRUUN3ME2zOE42PzB|IN88US=> NXzWSppkW0GQR1XS
MZ7-mel M{DwTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fINGlEPTB;M{SuOlQ5PyEQvF2= NUPKemlGW0GQR1XS
NCI-H810 M4PQZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;NRXhKSzVyPUO0MlczPzhizszN M2TxdXNCVkeHUh?=
D-392MG MnTKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHFTWM2OD1|NT6wOVY2KM7:TR?= NEfLcpBUSU6JRWK=
LB771-HNC MmDaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTN3LkG2OVgh|ryP NGfBc4ZUSU6JRWK=
COLO-679 NHexTWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnOPWlKSzVyPUO1MlM5QCEQvF2= M2TlcXNCVkeHUh?=
SK-PN-DW M{HodWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFq2VmlKSzVyPUO1MlQ{PjlizszN NEj3foZUSU6JRWK=
VA-ES-BJ MkPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;FVGlEPTB;M{WuOFY1QSEQvF2= M4DlWHNCVkeHUh?=
KNS-42 M33EfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HXWWlEPTB;M{WuOVgzPiEQvF2= NFHwZWtUSU6JRWK=
RVH-421 NHXuRnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPRTWM2OD1|NT63OlQ2KM7:TR?= NU\hW206W0GQR1XS
P30-OHK NWDwUo1LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrZTWM2OD1|NT64O|UzKM7:TR?= MWnTRW5ITVJ?
G-402 M2qyUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTITWM2OD1|NT65PFY4KM7:TR?= M3\CR3NCVkeHUh?=
S-117 M2XaUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnteGVmUUN3ME2zOk4{ODB6IN88US=> NFjvRXhUSU6JRWK=
RXF393 NGrXPZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLpdGNvUUN3ME2zOk4{Pzh3IN88US=> MlrnV2FPT0WU
LCLC-103H NEW2c|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTN4Lke4NFMh|ryP MVzTRW5ITVJ?
U-118-MG NWXWZ20zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LrXWlEPTB;M{[uPFg1PyEQvF2= MmLxV2FPT0WU
8-MG-BA MonQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3ruN2lEPTB;M{[uPVQ5OyEQvF2= NXHENmJbW0GQR1XS
MFH-ino MoHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFX4XZBKSzVyPUO3MlM{PzFizszN M3fEOHNCVkeHUh?=
NCI-H23 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DhSmlEPTB;M{euOFE6PiEQvF2= M2OwTnNCVkeHUh?=
NCI-H446 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTN5LkS4OlIh|ryP MVPTRW5ITVJ?
LU-99A M3L6[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTN5LkW3N|Eh|ryP MlfmV2FPT0WU
KP-N-YN M1PhSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PhXWlEPTB;M{euOlE6PSEQvF2= NFjGUGxUSU6JRWK=
SCC-9 NXz4[5VwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHLTWM2OD1|Nz63PFM5KM7:TR?= M1jDbHNCVkeHUh?=
EFM-19 M2K1N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrjdXVKSzVyPUO3Mlc6PjdizszN M4[0SXNCVkeHUh?=
A427 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mor0TWM2OD1|Nz65NVA4KM7:TR?= MoDJV2FPT0WU
LB831-BLC MlnHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTJTWM2OD1|OD62NFM6KM7:TR?= MkXpV2FPT0WU
HOS MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fEd2lEPTB;M{muOlI4OyEQvF2= NWLYU|MxW0GQR1XS
LAN-6 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTRyLkCxNVIh|ryP M4fkZnNCVkeHUh?=
U251 MlfOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXyxSVQyUUN3ME20NE41ODV2IN88US=> NXv1[YJvW0GQR1XS
SNU-387 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jISWlEPTB;NECuOFU2OyEQvF2= MkH3V2FPT0WU
DMS-79 M{Owe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnycWVtUUN3ME20NE42QDh7IN88US=> M{PVSHNCVkeHUh?=
SK-LU-1 MknsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\pU2lEPTB;NECuOlU3QCEQvF2= M1n1dHNCVkeHUh?=
HT MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnUS4d7UUN3ME20NE43PjN7IN88US=> NUjvfJJyW0GQR1XS
KP-N-YS MlXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DZSWlEPTB;NECuOlc3QCEQvF2= NGTiWmdUSU6JRWK=
DMS-114 M33P[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYmwXmVyUUN3ME20NE45Ozd2IN88US=> MWPTRW5ITVJ?
HUTU-80 MnvwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jHc2lEPTB;NEGuNFU3QSEQvF2= NVXYWGV6W0GQR1XS
ONS-76 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPCcFJKSzVyPUSxMlQ4ODlizszN MUjTRW5ITVJ?
A673 M3vBfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXVU|hIUUN3ME20NU42OTV5IN88US=> MmrtV2FPT0WU
HPAF-II MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTRzLk[3NFkh|ryP MkLoV2FPT0WU
UACC-257 Mn:yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnU[2NiUUN3ME20NU44OzZ7IN88US=> MXvTRW5ITVJ?
EW-22 NX7qZm5mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEG2XGlKSzVyPUSxMlg3QTdizszN NWLXfHhSW0GQR1XS
NCI-H1755 NEjITpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXIfXhpUUN3ME20NU45PzJ3IN88US=> M1PobXNCVkeHUh?=
KYSE-150 NVnyU3ZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIK0[mFKSzVyPUSyMlE4QDJizszN MnLiV2FPT0WU
CGTH-W-1 NIO4b4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTuTWM2OD12Mj60PVU2KM7:TR?= MVrTRW5ITVJ?
NB13 NVm0NZdIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrCcGVKSzVyPUSyMlYzOTdizszN MWXTRW5ITVJ?
SW872 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDTTWM2OD12Mj62N|MyKM7:TR?= Ml;TV2FPT0WU
KP-4 MoDSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTR{Lki4N|Ih|ryP NHzXSVlUSU6JRWK=
HCC38 NIPLU2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\rVVdKSzVyPUSyMlk3OThizszN NHrUTWJUSU6JRWK=
BB49-HNC NWrteGtST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrQTWM2OD12Mz6yN|U3KM7:TR?= MlLmV2FPT0WU
CAL-62 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LIV2lEPTB;NEOuOFAzQCEQvF2= MYDTRW5ITVJ?
NCI-H2029 MoHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGj4OHRKSzVyPUSzMlU2QDFizszN NF3SUnNUSU6JRWK=
M14 M4DWdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mki2TWM2OD12ND6xN|MzKM7:TR?= NGTQW2RUSU6JRWK=
COLO-680N M4G3O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTR2LkOzPUDPxE1? NEXXUW9USU6JRWK=
Hs-578-T MmD1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPvNmFKSzVyPUS1MlAzQTRizszN Mn3EV2FPT0WU
MSTO-211H NEiwTHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTR3Lkm0PFIh|ryP NILPUW9USU6JRWK=
EW-1 M4L1bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LTT2lEPTB;NEWuPVY5QSEQvF2= NXT6XW9SW0GQR1XS
SW948 M{\3PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULjPYpFUUN3ME20Ok41PDZ{IN88US=> NH:4S5dUSU6JRWK=
NCI-H460 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHtTWM2OD12Nj61NlMh|ryP NWW4eXNDW0GQR1XS
CAS-1 M1riTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoSyTWM2OD12Nj63O|AyKM7:TR?= MX3TRW5ITVJ?
TGBC11TKB M4rySGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4K5ZWlEPTB;NEeuNVc4PyEQvF2= NF;UfoJUSU6JRWK=
HD-MY-Z M1z0VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXVT3JYUUN3ME20PE44QDZizszN NHHmN2VUSU6JRWK=
NCI-H226 M3jyRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF75e2dKSzVyPUS5Mlc4QDVizszN M{GyT3NCVkeHUh?=
PA-1 M4LEfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTR7LkizN|Uh|ryP M3HEfHNCVkeHUh?=
LB2518-MEL NXnzTYtKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlu4TWM2OD12OT64O|I{KM7:TR?= NGjyZ2pUSU6JRWK=
A101D Mnz1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljLTWM2OD12OT65OFI2KM7:TR?= NWH6dIFIW0GQR1XS
NCI-H2087 NGLtNIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjGbZBjUUN3ME20PU46Pjh{IN88US=> MV7TRW5ITVJ?

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
CIP2A / p-AKT / AKT / PARP; 

PubMed: 25537503     


Time-dependent effects of afatinib on CIP2A, p-AKT and apoptosis-related proteins in the sensitive H358 and resistant H460 cells. Cells were exposed to 10 μM afatinib for up to 48 hours. Immunoblots were scanned and quantitated to determine the ratio of the level of CIP2A to actin. Data are mean ± SD. n = 3 for the different time intervals.

p-EGFR / p-IGF1R / p-ERK / p-AKT; 

PubMed: 26052929     


Effects of afatinib on EGFR and IGF1R Signaling Pathways. H1975 cells were treated with afatinib with various doses and cell lysates were subjected to Western blot analysis. Afatinib effectively inhibits p-EGFR and p-ERK while p-AKT was partially inhibited. IGF1R phosphorylation was increased upon afatinib treatment in H1975 cells.

p-VEGFR2 / VEGFR2 / JAG1 / DLL4 / NICD1 ; 

PubMed: 28533486     


HUVECs were cultured in the presence of Vatalanib (100 nM) or DBZ (10 nM) for 1 h and then treated for 15 min with rhgal-3 (37 nM) and cultured for additional 6 hrs. After this period, the total protein was isolated and the protein levels of galectin-3, NICD1, DLL4, JAG1, VEGFR2 and VEGFR2-p were assessed by Western blot. β-actin was used as a loading control.

25537503 26052929 28533486
Growth inhibition assay
Cell apoptosis; 

PubMed: 25537503     


Dose-dependent effects of afatinib on apoptosis. Data are mean ± SD. n = 3 for each concentration. *, p < 0.05, **, p < 0.01, vs. no afatinib. 

Cell viability; 

PubMed: 26515464     


A. MTS assay for Ba/F3 cells harboring EGFR exon 19 deletion and L858R. The proportional cell viability is shown. B. MTS assay for Ba/F3 cells harboring EGFR exon 19 deletion+T790M and L858R+T790M. The proportional cell viability is shown. C. MTS assay for Ba/F3 cells harboring wild type EGFR. The proportional cell viability is shown. Erlotinib, afatinib, osimertinib, and rociletinib were used as EGFR-TKIs. Error bars indicate standard deviation.

25537503 26515464
Immunofluorescence
p65; 

PubMed: 26317651     


Effects of different treatments on the nuclear translocation of the NF-κB subunit p65. A2780T cells were treated with 2.5 μM afatinib for 48 hours, or 10 μM PDTC for 2 hours. Subsequently, the NF-κB subunit p65 (red) was localized by immunofluorescence and a confocal microscopy. Nuclei were stained with DAPI (blue). Scale bar = 10 μM.

vacuoles; 

PubMed: 29713246     


Autophagy activation upon treatment with Afatinib and Sorafenib was validated using immunofluorescence in order to visualize a creation of autophagosomes; ×60 magnification. DMSO treatment was used as control. Green—autophagy vacuoles; Blue—Hoechst, nuclear staining. 

26317651 29713246
体内研究 活体研究时按实验对象体重,每千克口服20 mg BIBW2992持续25天,肿瘤产生明显的衰退现象,通过肿瘤切片的免疫组织化学染色观察发现,EGFR和AKT的磷酸化作用收到抑制。因此,正如lapatinib和neratinib, BIBW2992是次代酪氨酸激酶抑制剂,不可逆地抑制人类EGFR2(HER2)和EGFR激酶。BIBW2992不仅能和原代酪氨酸激酶如erlotinib和gefitinib一样有效抑制EGFR突变型,而且还能作用于抗erlotinib和gefitinib的EGFR。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

- 合并

体外激酶活性实验:

人类EGFR和L858R/T790M双重突变型EGFR 的酪氨酸激酶区域与谷胱甘肽巯基转移酶区域相接,提取酪氨酸激酶区域的方法见补充说明。在有和没有BIBW2992时分别测定酶活。使用杆状病毒系统克隆HER2激酶,用类似提取EGFR激酶域的方法提取HER2激酶域。
细胞实验:

[1]

- 合并
  • Cell lines: NSCLC细胞
  • Concentrations: 0-10 μM
  • Incubation Time: 1小时
  • Method:

    细胞按1×104密度转移到96孔板上,在无血清培养基上过夜培养,用于EGFR磷酸化实验。第二天添加包含BIBW2992的混合物,培养基在37oC温育1小时。在室温下用100 ng/ml EGF刺激10分钟。细胞用冰冻PBS冲洗,然后每孔用120 μl HEPEX buffer萃取,然后在室温下震荡1小时。每孔中所有2×104细胞都用于HER2磷酸化实验。在涂有链霉亲和素的板上加用封闭液按1:100比例稀释的抗EGFR的生物素和c-erb2/HER2肿瘤蛋白Ab-5-生物素。上述步骤得到的萃取物转移到有抗体包被的孔中,室温下温育1小时。彩色显影的测法见补充说明,吸光度为450纳米。


    (Only for Reference)
动物实验:

[1]

- 合并
  • Animal Models: 雌性无胸腺NMRI-nu/nu鼠
  • Dosages: 20 mg/kg
  • Administration: 口服处理
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 97 mg/mL (199.61 mM)
Ethanol 15 mg/mL (30.86 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
10mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 485.94
化学式

C24H25ClFN5O3

CAS号 439081-18-2
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04206787 Not yet recruiting Drug: Afatinib Non-squamous Non-Small Cell Lung Cancer Boehringer Ingelheim May 6 2020 --
NCT04158947 Recruiting Drug: Afatinib|Drug: T-DM1 HER2-positive Breast Cancer|Brain Metastases xuexin he|Second Affiliated Hospital School of Medicine Zhejiang University May 10 2020 Phase 2
NCT03711422 Not yet recruiting Drug: Afatinib Non-small Cell Lung Cancer|Leptomeningeal Disease|Central Nervous System Metastases National Cancer Centre Singapore October 2018 Phase 1
NCT03083678 Recruiting Drug: Afatinib Chordoma Leiden University Medical Center|Chordoma Foundation|Boehringer Ingelheim June 21 2018 Phase 2
NCT03370770 Completed Drug: Afatinib|Drug: Osimertinib Carcinoma Non-Small-Cell Lung Boehringer Ingelheim December 28 2017 --
NCT02423525 Recruiting Drug: Afatinib Brain Cancer Santosh Kesari|Boehringer Ingelheim|John Wayne Cancer Institute December 2016 Phase 1

技术支持

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操作手册

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常见问题及建议解决方法

  • 问题 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • 回答:

    For in vivo experiment of afatinib, we recommend 0.5% methylcellulose/0.2% Tween 80 as vehicle.

EGFR Signaling Pathway Map

EGFR Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID