Afatinib (BIBW2992)

目录号:S1011

Afatinib (BIBW2992) Chemical Structure

Molecular Weight(MW): 485.94

Afatinib (BIBW2992)不可逆地抑制EGFR/ErbB,包括EGFR(wt)EGFR(L858R),EGFR(L858R/T790M),ErbB2(HER2)和ErbB4(HER4),在无细胞试验中IC50分别为0.5 nM,0.4 nM,10 nM,14 nM和1 nM。

规格 价格 库存 购买数量  
RMB 1964.25 现货
RMB 977.68 现货
RMB 1724.11 现货
RMB 4652.69 现货
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客户购买Selleck的此次产品后发表的文献38篇:

客户使用该产品的4个实验数据:

  • Cytoxicity of irreversible EGFR TKIS and ethacrynic acid on breast cells lines. A, Mean IC50 value of Afatinib.

    Oncotarget, 2016, 7(36):58038-58050. Afatinib (BIBW2992) purchased from Selleck.

    Inhibition of signaling pathway activation in lung tumor cell lines by kinase inhibitors. Lung tumor cells were cultured in 10% FBS until reaching ∼80% confluence and then the cells were starved in serum-free medium for overnight, followed by 4-hour treatment with the inhibitors. Cell lysates were then prepared and used for determination of the pathway activation signals by the CEER assay.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

  • Inhibition of anchorage-independent growth of lung tumor cell lines by selected inhibitors. Each selected cell line was treated with the indicated inhibitor at 0.1 μM and 1 μM concentrations for two weeks and cell colony size formation was scored under the Nikon inverted-phase microscope.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

    After starved in serum-free medium for 24h, Breast cancer cells incubated with the indicated concentrations of BIBW2992 for 3h,followed by 15-minute stimolation of 100ng/ml EGF

    Dr. Zhang of Tianjin Medical University. Afatinib (BIBW2992) purchased from Selleck.

产品安全说明书

EGFR抑制剂选择性比较

生物活性

产品描述 Afatinib (BIBW2992)不可逆地抑制EGFR/ErbB,包括EGFR(wt)EGFR(L858R),EGFR(L858R/T790M),ErbB2(HER2)和ErbB4(HER4),在无细胞试验中IC50分别为0.5 nM,0.4 nM,10 nM,14 nM和1 nM。
靶点
EGFR (L858R) [1]
(Cell-free assay)
EGFR (wt) [1]
(Cell-free assay)
ErbB4 [2]
(Cell-free assay)
EGFR (L858R/T790M) [1]
(Cell-free assay)
HER2 [1]
(Cell-free assay)
0.4 nM 0.5 nM 1 nM 10 nM 14 nM
体外研究

BIBW2992不可逆地抑制EGFR/HER2,在体外作用于野生型EGFR ,L858R突变型EGFR, L858R/T790M 双突变型EGFR,及HER2时IC50分别为0.5, 0.4, 10, 14 nM。在体外实验中,BIBW2992不管作用于野生型EGFR/HER2还是突变型EGFR/HER2都显示出强大的活力,与gefitinib作用于L858R突变型EGFR的活力差不多,但是要比gefitinib 作用于L858R-T790M双突变型EGFR的活力大100倍。在体外,BIBW2992有效抑制所有实验类型细胞的EGFR/HER磷酸化作用。比如人类扁平上皮癌A431细胞系表达的野生型EGFR, 鼠类NIH-3T3细胞转染的野生型HER2 , 以及乳腺癌BT-474细胞系和胃癌NCI-N87细胞系表达的内源性HER2。[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HDLM-2 NYPh[lBVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHi1ZYtKSzVyPUCuNFA2PzJizszN M2\nU3NCVkeHUh?=
KASUMI-1 NYH2PJo5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfoTWM2OD1yLkCwPVEyKM7:TR?= NWnCSnpNW0GQR1XS
HCC2218 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTBwMEC5PFch|ryP MV3TRW5ITVJ?
KARPAS-45 NVTlVmR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXSSpZwUUN3ME2wMlAyPjdzIN88US=> NVTjPYp3W0GQR1XS
HSC-4 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFn0XFJKSzVyPUCuNFE4PDhizszN NWfaVnNwW0GQR1XS
CHL-1 NF\CPI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17zXmlEPTB;MD6wNVg{QSEQvF2= MX\TRW5ITVJ?
KY821 NES1XGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\heopKSzVyPUCuNFIxPiEQvF2= M3TtenNCVkeHUh?=
NCI-N87 NXLhWYR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{i0RWlEPTB;MD6wNlc4OyEQvF2= M1;ySnNCVkeHUh?=
DOK NY\2eIhNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDuTWM2OD1yLkCzNVk1KM7:TR?= NULw[G9TW0GQR1XS
DSH1 NFz2doFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nBWmlEPTB;MD6wN|MyPCEQvF2= MVrTRW5ITVJ?
MDA-MB-175-VII NFrpUpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIO5T|FKSzVyPUCuNFM1OTZizszN NGTVbXFUSU6JRWK=
NCI-H2170 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzETWM2OD1yLkCzO|I5KM7:TR?= M3vDXXNCVkeHUh?=
BT-474 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXWRXRKSzVyPUCuNFQ6QDZizszN MmnjV2FPT0WU
EFO-27 NHHiTlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vETWlEPTB;MD6wOVE5OiEQvF2= M4\ib3NCVkeHUh?=
NCI-H720 NUOyW2t[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\lNWJjUUN3ME2wMlA2OzJ3IN88US=> NE\hXYtUSU6JRWK=
PC-14 M33Qcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2npZmlEPTB;MD6wOVY3QCEQvF2= Mn7SV2FPT0WU
EC-GI-10 NFfmbVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwMEW5NVIh|ryP MoDCV2FPT0WU
KYSE-450 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTBwMEW5O|gh|ryP MXXTRW5ITVJ?
BPH-1 M3vzOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXaTWM2OD1yLkC1PVg5KM7:TR?= MWXTRW5ITVJ?
NCI-H292 NYXzOnlnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEGxeJdKSzVyPUCuNFYxQSEQvF2= Mn;aV2FPT0WU
H9 Mm\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLVTWM2OD1yLkC3NVMzKM7:TR?= MWnTRW5ITVJ?
NCI-H526 MnrvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWOyc4NlUUN3ME2wMlA4QDJ|IN88US=> M2n1bnNCVkeHUh?=
NCI-H1623 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV[0U2lGUUN3ME2wMlA5ODJ3IN88US=> NWDJN|YxW0GQR1XS
KYSE-140 M1n1R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDrTWM2OD1yLkC4N|Mh|ryP MmOyV2FPT0WU
Ca9-22 NYLMeHJXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfRNItKSzVyPUCuNFg{PTNizszN NYrFNnJmW0GQR1XS
AU565 NWKwcGNFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3GTWM2OD1yLkC4OVA1KM7:TR?= NVHNSZR1W0GQR1XS
ZR-75-30 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnTSW92UUN3ME2wMlA6PTR3IN88US=> NEjzU2JUSU6JRWK=
NCI-H1770 NHT0[nhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nYc2lEPTB;MD6xNFI5KM7:TR?= NIG0ZWdUSU6JRWK=
LB2241-RCC MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwMUC4PFQh|ryP M{DiUnNCVkeHUh?=
CAL-39 NYjmWHprT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TMWmlEPTB;MD6xNVc6OiEQvF2= NI\EV2RUSU6JRWK=
UACC-893 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXOTWM2OD1yLkGxPFg2KM7:TR?= MkniV2FPT0WU
LU-65 NHTzeWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHUTWM2OD1yLkGyOlM{KM7:TR?= MkPiV2FPT0WU
HN NHvaVWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwMUOwO|ch|ryP MVrTRW5ITVJ?
TI-73 Ml\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTBwMUS3NVUh|ryP NIC4Z|VUSU6JRWK=
KU812 NEfXV4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTjTWM2OD1yLkG1OFU3KM7:TR?= NHXYTXhUSU6JRWK=
SW13 NVWyNWVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwMU[yNVYh|ryP NGjoVY9USU6JRWK=
BB30-HNC M4XOfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nW[GlEPTB;MD6xOlU4PiEQvF2= M3vxbXNCVkeHUh?=
HSC-2 MmC4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrITWM2OD1yLkG2PFM4KM7:TR?= NIHMb2tUSU6JRWK=
BV-173 MoniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwMUe1PVYh|ryP NIO3[o1USU6JRWK=
CAL-27 MoTKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo[zTWM2OD1yLkG3OlM3KM7:TR?= NF65[5lUSU6JRWK=
SBC-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX:1Rm1vUUN3ME2wMlE5QTV7IN88US=> M2HXNXNCVkeHUh?=
CAL-33 NXz5UZF[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwMkCxPFQh|ryP NEDBNJdUSU6JRWK=
NCI-H209 Ml3WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfKNmhlUUN3ME2wMlIxPDZizszN NGDUdGtUSU6JRWK=
COR-L105 Ml:yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYT3NVU4UUN3ME2wMlIyODh2IN88US=> MYXTRW5ITVJ?
HSC-3 NYq2cYRDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\XVGlEPTB;MD6yNVE6QCEQvF2= Mo\HV2FPT0WU
NCI-H69 M3vPbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTBwMkG0OVEh|ryP M1vjSnNCVkeHUh?=
MOLT-13 NFnqPZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwMkO5O|Uh|ryP NF;5W4hUSU6JRWK=
ML-2 NVqwU3MyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnLWFQ5UUN3ME2wMlI1QDB{IN88US=> NWHVZolnW0GQR1XS
IGROV-1 M3viXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrKfHpyUUN3ME2wMlI2QTV{IN88US=> MUHTRW5ITVJ?
TK10 NXjxZ4VOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTBwMk[3N|gh|ryP NHzzeVVUSU6JRWK=
EoL-1-cell NGfaNphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvPWWRKSzVyPUCuNlY5QTJizszN M3u3eXNCVkeHUh?=
HO-1-N-1 NGPCc49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTBwMke4OVMh|ryP MXvTRW5ITVJ?
BHY MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUS3WYVTUUN3ME2wMlI5PjV3IN88US=> NFWwfXBUSU6JRWK=
LU-139 Mle3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwM{C1NUDPxE1? NGXWTndUSU6JRWK=
23132-87 M1nqcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwM{G5NlMh|ryP MXXTRW5ITVJ?
ACHN M2LCR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33MZ2lEPTB;MD6zNVk6PCEQvF2= NVriZ2p6W0GQR1XS
DoTc2-4510 NVfQcYdbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoiwTWM2OD1yLkOyNlE6KM7:TR?= MWnTRW5ITVJ?
BB65-RCC NFK4THJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTBwM{S1PVMh|ryP MYTTRW5ITVJ?
HLE MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVix[3I4UUN3ME2wMlM2ODR4IN88US=> NVSwSWVrW0GQR1XS
HCC1419 Mn70S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfncoVjUUN3ME2wMlM3PDB6IN88US=> NUTWdpd4W0GQR1XS
A388 M3uzc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUiwRmRrUUN3ME2wMlM3QDV5IN88US=> NF\Wb5BUSU6JRWK=
NUGC-3 NES5O5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonvTWM2OD1yLkO4N|c{KM7:TR?= MYjTRW5ITVJ?
KYSE-180 M36xeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTBwM{mwPFkh|ryP NIXZOYtUSU6JRWK=
TE-6 MmPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLlfpNNUUN3ME2wMlQxOjR4IN88US=> MX3TRW5ITVJ?
A498 NFq5TXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHXTWM2OD1yLkSwOlc1KM7:TR?= MlzPV2FPT0WU
NCI-H1648 NH7oS3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\yTW5KSzVyPUCuOFQyQDJizszN MWXTRW5ITVJ?
DU-145 MmHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnr4TWM2OD1yLkS0PFM{KM7:TR?= MX;TRW5ITVJ?
CW-2 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTBwNE[5NVQh|ryP MVjTRW5ITVJ?
A431 M3e2b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwNEiyN|Mh|ryP MkX2V2FPT0WU
SAS MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHGTWM2OD1yLkS4N|k5KM7:TR?= NUnlVmpWW0GQR1XS
NCI-H2126 M33aNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4f2d2lEPTB;MD61NVkzPiEQvF2= MoPMV2FPT0WU
NCI-H358 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3K1d2lEPTB;MD61N|IyKM7:TR?= MkLBV2FPT0WU
FADU NFH1fGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTBwNUS0NFQh|ryP Mn61V2FPT0WU
ACN M{PHSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwNUWwPVQh|ryP MVzTRW5ITVJ?
HCC70 Mn3YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwNUe2OlEh|ryP MV\TRW5ITVJ?
NCI-H1838 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwNkCyPVkh|ryP M1G5W3NCVkeHUh?=
CAL-54 MnO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7FTWM2OD1yLk[xOlIyKM7:TR?= NGrseHlUSU6JRWK=
NCI-H1975 NXzMRmhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWX5ZlNFUUN3ME2wMlYyPzJ6IN88US=> NF7KU3hUSU6JRWK=
COR-L88 MmjIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7aTWM2OD1yLk[0NVE{KM7:TR?= NHnvOFhUSU6JRWK=
CTV-1 NV;PTZRYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV34[lh{UUN3ME2wMlY1Ozl{IN88US=> MnjlV2FPT0WU
EW-18 Mmn4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrHUVQ4UUN3ME2wMlY5Pjl6IN88US=> MkTPV2FPT0WU
HCC1806 MnGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLk[ndKSzVyPUCuOlk3PjZizszN M3TSSHNCVkeHUh?=
HuP-T4 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlq5TWM2OD1yLk[5O|Yh|ryP MkjSV2FPT0WU
MDA-MB-361 NGPhS|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPFRnpKSzVyPUCuO|I3PjJizszN NHfBWFdUSU6JRWK=
NCI-H1573 NF\1bFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;kbmoyUUN3ME2wMlc{PjNizszN NHfSVZpUSU6JRWK=
KU-19-19 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwN{e0OlQh|ryP MYfTRW5ITVJ?
COLO-678 M2nxcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTBwOEC4N|Qh|ryP MVnTRW5ITVJ?
C-33-A MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PxW2lEPTB;MD64NVI6PyEQvF2= MnjmV2FPT0WU
Calu-3 NUfsN|lJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGmwV5BKSzVyPUCuPFE1OzRizszN MVfTRW5ITVJ?
AGS NYPoNG5KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTBwOEO2OFgh|ryP M4HwV3NCVkeHUh?=
SCC-25 MkjxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTBwOESxO|Eh|ryP MofuV2FPT0WU
JVM-2 NYC4V45QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17BT2lEPTB;MD64PFI6QSEQvF2= M2DufnNCVkeHUh?=
HCE-T MoDqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPXRmhKSzVyPUCuPFg1OjhizszN NHLqfZhUSU6JRWK=
ES4 M3i1XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnflTWM2OD1yLkm3PFM3KM7:TR?= MkHuV2FPT0WU
EKVX MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2qzWmlEPTB;MT6wNVA3PCEQvF2= MX\TRW5ITVJ?
D-542MG M4j4Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUj6TIVIUUN3ME2xMlAyODZ2IN88US=> MWjTRW5ITVJ?
SW1116 NWP4eJJPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXH3SoNQUUN3ME2xMlAyOjh5IN88US=> NVPK[3ZnW0GQR1XS
5637 M4TiOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2mycGlEPTB;MT6wNVUyKM7:TR?= NIjIcG1USU6JRWK=
HT-1376 M{ezbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37sPGlEPTB;MT6wNVUyOyEQvF2= M3rZcXNCVkeHUh?=
NB69 NGnFdmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3X1e2lEPTB;MT6wNlk1PSEQvF2= MWTTRW5ITVJ?
YKG-1 NUD4d|lWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTiSJAyUUN3ME2xMlA2PDF7IN88US=> M2TvcnNCVkeHUh?=
EW-3 NG\3eGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlG3TWM2OD1zLkC3PFg{KM7:TR?= MkfmV2FPT0WU
GCIY MlLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXhPFBKSzVyPUGuNFgyODRizszN MUjTRW5ITVJ?
SK-MES-1 NULIeHB3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjpR|FKSzVyPUGuNVE1QDdizszN NEXISZhUSU6JRWK=
PANC-08-13 Mk\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HlTGlEPTB;MT6xOlQyPiEQvF2= NIPDNW9USU6JRWK=
SK-NEP-1 MnnOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfHeZFKSzVyPUGuNVc2OTNizszN NF\VWplUSU6JRWK=
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Ca-Ski NHHYR5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\FTWM2OD15Lk[0NlU6KM7:TR?= MYPTRW5ITVJ?
HEL NHfmU4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\vVJJKSzVyPUeuO|EzODNizszN Ml\pV2FPT0WU
NH-12 NF\xSXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\ISWlEPTB;Nz63NlgxQCEQvF2= NYXmUmNIW0GQR1XS
LB373-MEL-D NGLZbnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHkRmtKSzVyPUeuO|Y4PzFizszN NFrKRVhUSU6JRWK=
SW900 M37QSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mki3TWM2OD15LkiyNVIyKM7:TR?= MY\TRW5ITVJ?
JVM-3 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXhSWtKSzVyPUeuPFk2QTlizszN NW\QZ5ZjW0GQR1XS
OAW-28 NVzYT4NuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;CTWM2OD15Lkm0OVc5KM7:TR?= NEXLW5RUSU6JRWK=
KURAMOCHI MlvaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTdwOUS4NVEh|ryP NGLZ[VJUSU6JRWK=
BE-13 NWLYeW9MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfwTWM2OD15Lkm4NVEzKM7:TR?= MoTxV2FPT0WU
VMRC-RCZ M2\MZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2i1NGlEPTB;OD6wNVY6PyEQvF2= NYnV[IN3W0GQR1XS
NCI-H727 NHi2VFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTxPXRKSzVyPUiuNVA1OiEQvF2= MnrkV2FPT0WU
SW1710 NEn2PYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRThwMUi1NVUh|ryP NYTMNlJTW0GQR1XS
D-502MG NYXaW2pMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRThwMkmyPFIh|ryP M3fUZXNCVkeHUh?=
NCI-H1993 MmDrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3NNZlKSzVyPUiuN|M3OzFizszN MULTRW5ITVJ?
SCC-4 M4rNOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRThwNESwOVkh|ryP Ml3iV2FPT0WU
HAL-01 MkK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfJTpNKSzVyPUiuOVE6OSEQvF2= M{XPSHNCVkeHUh?=
GT3TKB NHW4NpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRThwNke5OlQh|ryP MUTTRW5ITVJ?
SK-OV-3 NWHobXpxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRThwN{GzNlkh|ryP NFTnWG9USU6JRWK=
COLO-829 M3vFdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELzbWFKSzVyPUiuPFA6PzZizszN NXjyTpFHW0GQR1XS
OCI-AML2 NHX4VlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRThwOUW0PFEh|ryP NVW4dGYyW0GQR1XS
OS-RC-2 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTlwMEKxPUDPxE1? MmOzV2FPT0WU
BFTC-909 M336R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTlwME[3PVkh|ryP MnjKV2FPT0WU
EW-11 M1vHTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jMNGlEPTB;OT6xO|Y2OyEQvF2= MVTTRW5ITVJ?
HCE-4 NV:3WFVVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLDTWpKSzVyPUmuNlE2PThizszN NFjZU3JUSU6JRWK=
BALL-1 NIfvfWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;0SWtKSzVyPUmuNlE6ODdizszN NFXEZZRUSU6JRWK=
SF539 MoPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTlwMkO1OlIh|ryP MlrFV2FPT0WU
CAMA-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDOTWM2OD17LkK4NVI5KM7:TR?= NVu1bW5[W0GQR1XS
C32 NF:3PYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXqybHhqUUN3ME25MlM{ODZ2IN88US=> NUTZU5RHW0GQR1XS
NCI-H1703 NIHXSm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTlwM{SzO|Uh|ryP MnjVV2FPT0WU
NCI-H1650 NGe1W41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzD[WtkUUN3ME25MlYxQTR4IN88US=> NEi5T|FUSU6JRWK=
NCI-H1563 M3PWV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo[0TWM2OD17Lke2NFMyKM7:TR?= M2PHdHNCVkeHUh?=
CAL-85-1 MkjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTITWM2OD17Lki3N|g{KM7:TR?= M1GycHNCVkeHUh?=
UM-UC-3 NFPjVGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2L2NWlEPTB;OT65OVA{KM7:TR?= Ml:1V2FPT0WU
BxPC-3 M1jLPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\zW2FIUUN3ME2xNE4xQTd{IN88US=> NF;2RpVUSU6JRWK=
MHH-PREB-1 MnLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTFyLkG5PVkh|ryP NXvUVmF1W0GQR1XS
DEL MmezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrxTXJKSzVyPUGwMlM6PDZizszN MV\TRW5ITVJ?
HuCCT1 NUTSd4p4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLpTWM2OD1zMD62NFM{KM7:TR?= NF;GNYpUSU6JRWK=
OVCAR-4 M1PGNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37Vc2lEPTB;MUCuPFg{PSEQvF2= MkXRV2FPT0WU
CAL-72 NUCzVFZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn2zTWM2OD1zMD65N|kyKM7:TR?= MUnTRW5ITVJ?
HCC1954 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXXbYE5UUN3ME2xNU4xPzV2IN88US=> MkHLV2FPT0WU
EFO-21 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPHNJNpUUN3ME2xNU4yODR3IN88US=> MXXTRW5ITVJ?
FTC-133 M124bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrTZ2dKSzVyPUGxMlE1ODdizszN MnnwV2FPT0WU
SK-MEL-24 M3W3NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHCcpRKSzVyPUGxMlI{PjZizszN NHPwfJFUSU6JRWK=
UACC-62 NFjaS21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTFzLkKzOlgh|ryP NF31XppUSU6JRWK=
NCI-H650 M13pSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTFzLkK0NVgh|ryP NVn2XW5pW0GQR1XS
ALL-PO Mn3oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHGSVNyUUN3ME2xNU4zPTF{IN88US=> Mk\VV2FPT0WU
T84 MkjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\iSItZUUN3ME2xNU4{QTB5IN88US=> M3m4eXNCVkeHUh?=
IST-MEL1 M1zoW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17nd2lEPTB;MUGuOFU2QSEQvF2= MXTTRW5ITVJ?
SW626 Moi3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jMbmlEPTB;MUGuOVc2PSEQvF2= MWXTRW5ITVJ?
RPMI-2650 NHm2fWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTFzLkW4PFUh|ryP M1fRUHNCVkeHUh?=
MC-IXC MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEK3c2ZKSzVyPUGxMlY4OjhizszN M4fOTnNCVkeHUh?=
HOP-62 M13zPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHDepNKSzVyPUGxMlY4PjRizszN MkTCV2FPT0WU
NOS-1 NVjFcmtJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTFzLkexNFkh|ryP MXLTRW5ITVJ?
SW1573 NI\5PWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{SwTWlEPTB;MUGuO|I6PSEQvF2= NFTNZmJUSU6JRWK=
WM-115 M4LSWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFz3OJNKSzVyPUGxMlc2QDhizszN NVntNIhsW0GQR1XS
HuO9 M3\p[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M36wUmlEPTB;MUGuPFc4PCEQvF2= MV;TRW5ITVJ?
YAPC MmXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXzXZRKSzVyPUGxMlkzPTlizszN MkPuV2FPT0WU
MDA-MB-453 M1nQcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HVTWlEPTB;MUGuPVUyPSEQvF2= MlvUV2FPT0WU
NCI-H596 NFm2fHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1z6NGlEPTB;MUKuNFM3QSEQvF2= M3;yR3NCVkeHUh?=
A172 MmLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTF{LkC3PVgh|ryP M{n3b3NCVkeHUh?=
RS4-11 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTF{LkG3NlUh|ryP NV2xNGFnW0GQR1XS
HCC1937 Mn7rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTuWo1UUUN3ME2xNk44PTZ2IN88US=> NHzIe2VUSU6JRWK=
SW837 M2LHTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTF{LkmwNlgh|ryP NHLhPYxUSU6JRWK=
NMC-G1 M3\WfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13IZmlEPTB;MUKuPVI{PCEQvF2= MVnTRW5ITVJ?
PFSK-1 MlHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLZcXl7UUN3ME2xN{4xPiEQvF2= NIHVdpJUSU6JRWK=
DBTRG-05MG NEfpcIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HtZ2lEPTB;MUOuNFY{OiEQvF2= MkjpV2FPT0WU
SK-UT-1 M3zyPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LmT2lEPTB;MUOuNVA5OyEQvF2= MYnTRW5ITVJ?
OVCAR-5 M1XCNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PCPWlEPTB;MUOuNVU6OyEQvF2= MYPTRW5ITVJ?
8505C Mk[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTF|LkKwOlch|ryP NWnEc3FGW0GQR1XS
SK-MEL-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkexTWM2OD1zMz63NVM2KM7:TR?= M3nMPXNCVkeHUh?=
LK-2 MoCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnQcVBKSzVyPUGzMlc3OzlizszN MYrTRW5ITVJ?
OE33 NIXDW5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXP6fFJlUUN3ME2xN{44QDZizszN M1[ycnNCVkeHUh?=
Ramos-2G6-4C10 MojwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTBOmtYUUN3ME2xOE4xOjB{IN88US=> M2faXHNCVkeHUh?=
EW-13 M3;vPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTF2LkCzOVIh|ryP MVzTRW5ITVJ?
NCI-H1793 M1PidGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HDWWlEPTB;MUSuNlA5PyEQvF2= NXyweWJjW0GQR1XS
BHT-101 NVPFW5k4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPuSJdKSzVyPUG0MlI1OSEQvF2= NIXaeppUSU6JRWK=
RKO MmXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nPOWlEPTB;MUSuOVA4PSEQvF2= MlP5V2FPT0WU
NEC8 MlzhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\uXWlEPTB;MUSuOVQ4OiEQvF2= NEDOTGpUSU6JRWK=
PANC-10-05 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTF2Lk[yOFch|ryP M{joXXNCVkeHUh?=
NCI-H2030 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTF2Lk[0OFgh|ryP NWXuenE{W0GQR1XS
C2BBe1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\T[5E5UUN3ME2xOE44PjRizszN NX:4fpBpW0GQR1XS
EM-2 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zjUGlEPTB;MUSuPFU4PiEQvF2= MUXTRW5ITVJ?
HCC1395 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTF2LkmzN|gh|ryP MmPDV2FPT0WU
A2058 M{nF[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3FTWM2OD1zNT6wOFA6KM7:TR?= M4myVnNCVkeHUh?=
SW1463 NYH2b2VHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{P0WmlEPTB;MUWuNFQ5PSEQvF2= Ml;TV2FPT0WU
J82 NEGzOGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEj0U25KSzVyPUG1MlA2PyEQvF2= Mon0V2FPT0WU
CAL-120 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFztZXlKSzVyPUG1MlE1PDdizszN NULmfoNRW0GQR1XS
COLO-824 NVTLbWlbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljiTWM2OD1zNT6xOVc6KM7:TR?= NYK2T4VDW0GQR1XS
LNCaP-Clone-FGC NEXMXJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mli3TWM2OD1zNT60NlQ5KM7:TR?= MU\TRW5ITVJ?
CP66-MEL NUnWblFjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFX4fZdKSzVyPUG1MlQ3QDhizszN NUnscGF[W0GQR1XS
OC-314 NVruZoc4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXT2N41QUUN3ME2xOU41PzF2IN88US=> MVXTRW5ITVJ?
OVCAR-8 NHLLfHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHacFVKSzVyPUG1Mlg5PjFizszN MmTIV2FPT0WU
MFE-280 MkC0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYX2NHFPUUN3ME2xOk4xPDh6IN88US=> NInEfHZUSU6JRWK=
MHH-NB-11 NHnPOmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTxeJRUUUN3ME2xOk4xQDN7IN88US=> M1XFfXNCVkeHUh?=
SW1990 M3;UdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPTTWM2OD1zNj6xO|U2KM7:TR?= MknwV2FPT0WU
U-266 MlnSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF[3T|FKSzVyPUG2MlIzQTlizszN MXrTRW5ITVJ?
MFM-223 NGnQV4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3Hs[mlEPTB;MU[uN|k3PSEQvF2= NYP6bohtW0GQR1XS
L-363 NVjwfmR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVSzVVlsUUN3ME2xOk41PTd5IN88US=> MofGV2FPT0WU
MCF7 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1j4VmlEPTB;MU[uOFczOyEQvF2= NYnteZlnW0GQR1XS
SK-MEL-3 NVPyZW9QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nVdmlEPTB;MU[uOFc5PyEQvF2= MXLTRW5ITVJ?
HH Mm\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXLTWM2OD1zNj61NVYzKM7:TR?= Mn7aV2FPT0WU
no-10 NWLP[VNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkH6TWM2OD1zNj62N|Q{KM7:TR?= M{D0SHNCVkeHUh?=
HuP-T3 NIOzN41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\qZ25KSzVyPUG2MlY2PzZizszN NHjLPHNUSU6JRWK=
QIMR-WIL M1\RPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHCTWM2OD1zNj63NVA2KM7:TR?= NVL4dWR{W0GQR1XS
NCI-H1092 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTF4LkizNVYh|ryP M{HBcHNCVkeHUh?=
MZ2-MEL NILXZ4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTF4Lki0NFMh|ryP NYHjVo9rW0GQR1XS
ES3 MkT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTF4LkmxN|Qh|ryP MnjHV2FPT0WU
COLO-684 M4jJdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TaeWlEPTB;MU[uPVQ4PyEQvF2= NILXWFVUSU6JRWK=
NCI-H661 NHrG[XVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\1O4FKSzVyPUG2Mlk3QTRizszN NH3RZmZUSU6JRWK=
CP50-MEL-B MlWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn36TWM2OD1zNz6wN|Q{KM7:TR?= MXHTRW5ITVJ?
NCI-H2405 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTnO4xFUUN3ME2xO{4yQTd2IN88US=> MXLTRW5ITVJ?
U-2-OS Mkf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPNWoNtUUN3ME2xO{42OzB5IN88US=> MXzTRW5ITVJ?
RERF-LC-MS NFrwZ|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTF5LkW1NFgh|ryP MVHTRW5ITVJ?
NCI-H2342 NGi4cGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M323bmlEPTB;MUeuOVU4KM7:TR?= NF:4V2pUSU6JRWK=
ES8 NVTMfZoxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVG1ZWI4UUN3ME2xO{43ODh5IN88US=> NFLJe3FUSU6JRWK=
MOLT-16 NXG5VFgyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTF5Lki5N|Qh|ryP MoHWV2FPT0WU
RH-18 M1nmOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LzTWlEPTB;MUiuNFA{PSEQvF2= NVrsZ5NbW0GQR1XS
D-283MED M1OxSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPGeWo5UUN3ME2xPE4xODh6IN88US=> MVTTRW5ITVJ?
RCC10RGB MknKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\uTWM2OD1zOD6wOVU6KM7:TR?= MWjTRW5ITVJ?
NCI-H1437 MoD1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HvemlEPTB;MUiuNVY1OSEQvF2= M2\aUXNCVkeHUh?=
SW982 MoToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\BTWM2OD1zOD6yOlcyKM7:TR?= MljCV2FPT0WU
IST-MES1 NEfrOndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDmeoNWUUN3ME2xPE41PDJ6IN88US=> M{\DWHNCVkeHUh?=
A704 M2HNc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTF6LkS3OVMh|ryP NXLoPGl1W0GQR1XS
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SCH M4jwN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3W2VWlEPTB;MUiuOlQ2PiEQvF2= M1vhNXNCVkeHUh?=
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LU-135 NF24UGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fLc2lEPTB;M{OuPFgzQSEQvF2= NFPUVnRUSU6JRWK=
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T-24 MoHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnSTWM2OD1|ND6wNlA2KM7:TR?= M3PVfnNCVkeHUh?=
Mewo MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfYTWM2OD1|ND6xN|Q6KM7:TR?= NFvXcXZUSU6JRWK=
22RV1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTN2LkG3OVQh|ryP MWTTRW5ITVJ?
KM-H2 M2\yN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrGZWhKSzVyPUO0MlE4PzlizszN MYTTRW5ITVJ?
NCI-H2122 M1rTPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XnSmlEPTB;M{SuN|Q4OSEQvF2= MUfTRW5ITVJ?
ABC-1 MmXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3L4S2lEPTB;M{SuN|Y6OyEQvF2= NEnxcpZUSU6JRWK=
NCI-H1355 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nPXWlEPTB;M{SuN|g5QSEQvF2= NV;ueW1CW0GQR1XS
NOMO-1 M2TOeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jCd2lEPTB;M{SuOVcxOyEQvF2= NIHZeYVUSU6JRWK=
MZ7-mel NVSyUphXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTN2Lk[0PFch|ryP M2PVRXNCVkeHUh?=
NCI-H810 NFvlZlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3ETWM2OD1|ND63Nlc5KM7:TR?= NX;XS25yW0GQR1XS
D-392MG NFO0e2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzqZXVIUUN3ME2zOU4xPTZ3IN88US=> NHzWZplUSU6JRWK=
LB771-HNC MoDES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{[3c2lEPTB;M{WuNVY2QCEQvF2= MofNV2FPT0WU
COLO-679 MlXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnu5TWM2OD1|NT6zPFgh|ryP MlrHV2FPT0WU
SK-PN-DW NE\uepZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTN3LkSzOlkh|ryP M3rudHNCVkeHUh?=
VA-ES-BJ NGDRTlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PaS2lEPTB;M{WuOFY1QSEQvF2= NVK2cnZ7W0GQR1XS
KNS-42 NXXiSWx3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\1TWM2OD1|NT61PFI3KM7:TR?= NGn0PVNUSU6JRWK=
RVH-421 NXSzUFFNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnZTWM2OD1|NT63OlQ2KM7:TR?= MkfPV2FPT0WU
P30-OHK M{G4[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkn0TWM2OD1|NT64O|UzKM7:TR?= MmXBV2FPT0WU
G-402 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\4e5NKSzVyPUO1Mlk5PjdizszN NGn0NXNUSU6JRWK=
S-117 M4DyZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nYeGlEPTB;M{[uN|AxQCEQvF2= MYjTRW5ITVJ?
RXF393 M1\sTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fxZWlEPTB;M{[uN|c5PSEQvF2= NXrlSoFkW0GQR1XS
LCLC-103H M1X1SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTN4Lke4NFMh|ryP MUHTRW5ITVJ?
U-118-MG NWLBVHhbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDLXJVKSzVyPUO2Mlg5PDdizszN M1jobnNCVkeHUh?=
8-MG-BA MlPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;STWM2OD1|Nj65OFg{KM7:TR?= MYHTRW5ITVJ?
MFH-ino NWfrRpdzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PuNGlEPTB;M{euN|M4OSEQvF2= MkTFV2FPT0WU
NCI-H23 MlzMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjETWM2OD1|Nz60NVk3KM7:TR?= NES3c3dUSU6JRWK=
NCI-H446 MmX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIn4[FZKSzVyPUO3MlQ5PjJizszN NF6xb41USU6JRWK=
LU-99A MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPJNlZRUUN3ME2zO{42PzNzIN88US=> NED6bGpUSU6JRWK=
KP-N-YN MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XLfWlEPTB;M{euOlE6PSEQvF2= MX3TRW5ITVJ?
SCC-9 MmfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1m2VGlEPTB;M{euO|g{QCEQvF2= NUjTbVFnW0GQR1XS
EFM-19 MnPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3RTWM2OD1|Nz63PVY4KM7:TR?= MojFV2FPT0WU
A427 NEntd5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPw[5RqUUN3ME2zO{46OTB5IN88US=> MnTPV2FPT0WU
LB831-BLC MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHT6OoRKSzVyPUO4MlYxOzlizszN MX3TRW5ITVJ?
HOS NGXFOJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTrTWM2OD1|OT62Nlc{KM7:TR?= MkDPV2FPT0WU
LAN-6 NYHOfJBQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYW4cYJpUUN3ME20NE4xOTF{IN88US=> NFTXeXBUSU6JRWK=
U251 MnHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPMTWM2OD12MD60NFU1KM7:TR?= MmXhV2FPT0WU
SNU-387 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTRyLkS1OVMh|ryP MYPTRW5ITVJ?
DMS-79 Mo\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEn6XopKSzVyPUSwMlU5QDlizszN MWLTRW5ITVJ?
SK-LU-1 NX\rW21ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTRyLk[1Olgh|ryP NFnYelJUSU6JRWK=
HT MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2foXWlEPTB;NECuOlY{QSEQvF2= MWjTRW5ITVJ?
KP-N-YS NHS3U3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrOO25YUUN3ME20NE43PzZ6IN88US=> NUDwWY9MW0GQR1XS
DMS-114 MljlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\nUohKSzVyPUSwMlg{PzRizszN NVezdI45W0GQR1XS
HUTU-80 Ml33S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTRzLkC1Olkh|ryP MX;TRW5ITVJ?
ONS-76 M{n6PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTRzLkS3NFkh|ryP M3z3WXNCVkeHUh?=
A673 M4PucGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoS4TWM2OD12MT61NVU4KM7:TR?= NULXVXFYW0GQR1XS
HPAF-II NVvXVZpjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTRzLk[3NFkh|ryP NV3oV5hEW0GQR1XS
UACC-257 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfzdphNUUN3ME20NU44OzZ7IN88US=> MXrTRW5ITVJ?
EW-22 M2fRU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTRzLki2PVch|ryP NH36SXlUSU6JRWK=
NCI-H1755 NF;sOFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTRzLki3NlUh|ryP MlPiV2FPT0WU
KYSE-150 M{n5fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HESWlEPTB;NEKuNVc5OiEQvF2= NGLKdHZUSU6JRWK=
CGTH-W-1 M2nERmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLPTWM2OD12Mj60PVU2KM7:TR?= MXLTRW5ITVJ?
NB13 Mn\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF24blhKSzVyPUSyMlYzOTdizszN NYjzdVJEW0GQR1XS
SW872 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTNTWM2OD12Mj62N|MyKM7:TR?= MYfTRW5ITVJ?
KP-4 NUnhT3NqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTR{Lki4N|Ih|ryP Mn7UV2FPT0WU
HCC38 NFvX[2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnWT4w1UUN3ME20Nk46PjF6IN88US=> M17PN3NCVkeHUh?=
BB49-HNC MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTR|LkKzOVYh|ryP MWHTRW5ITVJ?
CAL-62 NWPrUFhPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXGzPI9CUUN3ME20N{41ODJ6IN88US=> NH7SOplUSU6JRWK=
NCI-H2029 NXLUOoFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPEW|JKSzVyPUSzMlU2QDFizszN NELnVGtUSU6JRWK=
M14 NV\tVGszT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTud5J2UUN3ME20OE4yOzN{IN88US=> NEL2NZNUSU6JRWK=
COLO-680N MmT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmi4TWM2OD12ND6zN|kh|ryP NVu2WYpoW0GQR1XS
Hs-578-T MnrKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2e5bmlEPTB;NEWuNFI6PCEQvF2= MlrlV2FPT0WU
MSTO-211H NF3CU|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUS3dW5LUUN3ME20OU46PDh{IN88US=> M1LTTHNCVkeHUh?=
EW-1 M37TS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTR3Lkm2PFkh|ryP NInJb4lUSU6JRWK=
SW948 MoXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7iS4ZKSzVyPUS2MlQ1PjJizszN NYrsXFVJW0GQR1XS
NCI-H460 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFntR25KSzVyPUS2MlUzOyEQvF2= MUTTRW5ITVJ?
CAS-1 NG\pTZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3YTWM2OD12Nj63O|AyKM7:TR?= NU[wU|NXW0GQR1XS
TGBC11TKB NYfSdIsyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13TOWlEPTB;NEeuNVc4PyEQvF2= MV\TRW5ITVJ?
HD-MY-Z MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTR6Lke4OkDPxE1? NXjjNmZOW0GQR1XS
NCI-H226 MmH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHZ[|lqUUN3ME20PU44Pzh3IN88US=> MnPPV2FPT0WU
PA-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTR7LkizN|Uh|ryP NFWxVWVUSU6JRWK=
LB2518-MEL MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjMfHhKSzVyPUS5Mlg4OjNizszN NFW3cndUSU6JRWK=
A101D MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DiSGlEPTB;NEmuPVQzPSEQvF2= MWrTRW5ITVJ?
NCI-H2087 M4f4Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\QeZBKSzVyPUS5Mlk3QDJizszN MUHTRW5ITVJ?

... Click to View More Cell Line Experimental Data

体内研究 活体研究时按实验对象体重,每千克口服20 mg BIBW2992持续25天,肿瘤产生明显的衰退现象,通过肿瘤切片的免疫组织化学染色观察发现,EGFR和AKT的磷酸化作用收到抑制。因此,正如lapatinib和neratinib, BIBW2992是次代酪氨酸激酶抑制剂,不可逆地抑制人类EGFR2(HER2)和EGFR激酶。BIBW2992不仅能和原代酪氨酸激酶如erlotinib和gefitinib一样有效抑制EGFR突变型,而且还能作用于抗erlotinib和gefitinib的EGFR。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

+ 展开

体外激酶活性实验:

人类EGFR和L858R/T790M双重突变型EGFR 的酪氨酸激酶区域与谷胱甘肽巯基转移酶区域相接,提取酪氨酸激酶区域的方法见补充说明。在有和没有BIBW2992时分别测定酶活。使用杆状病毒系统克隆HER2激酶,用类似提取EGFR激酶域的方法提取HER2激酶域。
细胞实验:

[1]

+ 展开
  • Cell lines: NSCLC细胞
  • Concentrations: 0-10 μM
  • Incubation Time: 1小时
  • Method:

    细胞按1×104密度转移到96孔板上,在无血清培养基上过夜培养,用于EGFR磷酸化实验。第二天添加包含BIBW2992的混合物,培养基在37oC温育1小时。在室温下用100 ng/ml EGF刺激10分钟。细胞用冰冻PBS冲洗,然后每孔用120 μl HEPEX buffer萃取,然后在室温下震荡1小时。每孔中所有2×104细胞都用于HER2磷酸化实验。在涂有链霉亲和素的板上加用封闭液按1:100比例稀释的抗EGFR的生物素和c-erb2/HER2肿瘤蛋白Ab-5-生物素。上述步骤得到的萃取物转移到有抗体包被的孔中,室温下温育1小时。彩色显影的测法见补充说明,吸光度为450纳米。


    (Only for Reference)
动物实验:

[1]

+ 展开
  • Animal Models: 雌性无胸腺NMRI-nu/nu鼠
  • Formulation: 0.5%甲基纤维素-0.4% Tween-80
  • Dosages: 20 mg/kg
  • Administration: 口服处理
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 97 mg/mL (199.61 mM)
Ethanol 15 mg/mL (30.86 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
10mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 485.94
化学式

C24H25ClFN5O3

CAS号 439081-18-2
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03727724 Not yet recruiting Carcinoma Non-Small-Cell Lung The Netherlands Cancer Institute|Boehringer Ingelheim|Merck Serono International SA November 2018 Phase 2
NCT03695510 Not yet recruiting Head and Neck Neoplasms National Taiwan University Hospital November 2018 Phase 2
NCT03652233 Not yet recruiting Recurrent Squamous Cell Carcinoma of the Head or Neck|Platinum- and Cetuximab-Refractory Squamous Cell Carcinoma of the Head or Neck|Metastatic Squamous Cell Carcinoma of the Head or Neck|Squamous Cell Carcinoma Vanderbilt-Ingram Cancer Center|National Comprehensive Cancer Network|Boehringer Ingelheim November 2018 Phase 1
NCT03711422 Not yet recruiting Non-small Cell Lung Cancer|Leptomeningeal Disease|Central Nervous System Metastases National Cancer Centre Singapore October 2018 Phase 1
NCT03574402 Not yet recruiting Carcinoma Non-Small-Cell Lung Guangdong Association of Clinical Trials July 1 2018 Phase 2
NCT03083678 Recruiting Chordoma Leiden University Medical Center|Chordoma Foundation|Boehringer Ingelheim June 21 2018 Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • 回答:

    For in vivo experiment of afatinib, we recommend 0.5% methylcellulose/0.2% Tween 80 as vehicle.

EGFR Signaling Pathway Map

EGFR Inhibitors with Unique Features

相关EGFR产品

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID