Gefitinib (ZD1839)

目录号:S1025

Gefitinib (ZD1839) Chemical Structure

Molecular Weight(MW): 446.90

Gefitinib (ZD1839)是一种EGFR抑制剂,作用于NR6wtEGFR和NR6W细胞中的Tyr1173,Tyr992,Tyr1173和Tyr992,IC50 分别为37 nM,37nM,26 nM和57 nM。

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客户使用Selleck该产品发表文献95篇:

客户使用该产品的14个实验数据:

  • c, HCC4006 lung cancer cells that have acquired a high-mesenchymal state concomitant with becoming resistant to gefitinib (red curve) exhibit increased sensitivity to GPX4 inhibition.

    Nature, 2017, 547(7664):453-457. Gefitinib (ZD1839) purchased from Selleck.

    Perturbation of EGFR by its ligand EGF and gefitinib (ZD-1839 Iressat; inhibits EGFR) produces opposite responses in the predicted EGFR target genes SOCS2 and NR2E1.

    Mol Syst Biol 2011 7, 486. Gefitinib (ZD1839) purchased from Selleck.

  • Effects of shRNA-mediated RECK depletion on EGFR signaling in MEFs. (a) Immunoblotting (IB) of the indicated proteins in wild-type MEFs transduced with the indicated shRNAs and cultured for 48 h in the presence of 0.1% dimethyl sulfoxide (DMSO; vehicle) or 1 mM gefitinib (S1025, Selleck Chemicals,Houston, TX, USA). (b) Immunoprecipitation from whole lysates of cells from panel a with an anti-phosphorylated tyrosine (pTyr) antibody. Precipitates from 500 mg protein in whole cell lysates (upper) or 20 mg protein in whole cell lysates (lower) were analyzed by IB with anti-EGFR antibody.

    Oncogene 2010 30, 737-750. Gefitinib (ZD1839) purchased from Selleck.

    (B–C) LNCaP (B) and LNCaP-AI (C) cells were transiently transfected with sPLA2-IIa(-800)-Luc (0.5 μg). The cells were then treated with Erlotinib (20 μM), Gefitinib (20 μM), Lapatinib (20 μM), CI-1033 (8 μM), LY294002 (20 lM) and Bortezomib (20 μM) without or with EGF (100 ng/ml) for 24 h. Luciferase assay was performed according to a standard protocol with Renilla luciferase as an internal control. Data are presented as the mean (±SD) of duplicate values of a representative experiment that was independently repeated for five times.

    Carcinogenesis 2010 31, 1948–1955 . Gefitinib (ZD1839) purchased from Selleck.

  • LNCaP-AI cells were starved in 1% stripped medium for 24 h. The cells were then treated with Erlotinib (20 μM), Gefitinib (20 μM), Lapatinib (20 μM), CI-1033 (8 μM), LY294002 (20 μM) and Bortezomib (20 μM) for 24 h. Cell culture medium was collected from each sample and subjected to ELISA for sPLA2-IIa. The condition medium samples were diluted 10 times for ELISA. Average of duplicate samples was converted to nanogram per milliliter against standard curve. The data represent one of five repeated experiments.

     

     

    Carcinogenesis 2010 31, 1948–1955. Gefitinib (ZD1839) purchased from Selleck.

    Suppression of EGFR signaling by Gefitinib is dose dependent and non- toxic at millimolar concentrations.Results from plaque reduction tests of Hep2 cells infected with VACV(12.5pfu/well) treated with a serial dilution of Gefitinib (1000-0.01 m) and analyzed for (A)proliferation as indicator of cytotoxicity,(B) IC50 of plaque size inhibition, (C)dose dependent inhibition of EGFR-ERK1/2signaling and VACV proteins by Western blot analysis (pEGFR detection was obtained from a different experiment with identicals ettings) and (D)dose dependent inhibition of orthopoxvirus genome replication by real-time PCR.Untreated VACV infectedcells and uninfected cells are shown as controls in the right panel.

    Antiviral Res 2010 89, 64-70. Gefitinib (ZD1839) purchased from Selleck.

  • A circular zone of EGFR activated but uninfected cells facilitate virus induced plaque development , efficiently blocked by Gefitinib. (A)Immun of luorescent staining of aplaque reduction tests with Hep2 cells 24,48,72 and 96 h after VACV infection (6.25pfu/chamber). VACV infected cells(green) were visualized by human IgG directed to orthopoxviruses (VIG) detected with a secondary FITC labelled antibody. Uninfected cells with activated EGFR signaling(red) are detected with a secondary Cy3labelled antibody. Positive cells for both , VACV and phosphorylated EGFR are shown in yellow(merge). Cellular nuclei are counterstained with DAPI. (B)Immunofluorescent staining of a plaque reduction test as described for (A) and treated with three different Gefitinib concentrations (1000 nM, 1 nM, and 0.01 nM) . The test was analyzed 96h afterVACV infection.Uninfected cells are shown as controls. Magnification100×.(For interpretation of the references to color in this figure legend , the reader is referred to the web version of the article.)

     

     

    Antiviral Res 2010 89, 64-70. Gefitinib (ZD1839) purchased from Selleck.

    Susceptibility of lung cancer cells to cytolytic activity of NK-92 cells after treatment with EGFR inhibitors. Three lung cancer cells were untreated (open circle) or treated with 10 μM erlotinib or gefitinib (black filled square or black filled triangle) for 24 hours. The lung cancer cells were cocultured with NK-92 cells at indicated effector to target ratio (E:T ratio). To determine the specificity of NKG2D-mediated cytolysis of lung cancer cells, NK-92 cells were preincubated with blocking mAb against NKG2D before the assay (gray filled square and triangle) and correspond-ing isotype mAb (open square and triangle).

    J Immunother 2011 34(4), 372-81. Gefitinib (ZD1839) purchased from Selleck.

  • Inhibition of 5-HT-induced 5-HT3A and 5-HT3AB receptor currents.

    Eur J Pharmacol, 2017, 821:21-28. Gefitinib (ZD1839) purchased from Selleck.

    The EGF-dependent increased association of PCM1 and AZI1 requires EGFR kinase activity. ZD1839 (Iressa)—EGFR tyrosine kinase inhibitor.

    Mol Biosyst 2011 7, 3223-33. Gefitinib (ZD1839) purchased from Selleck.

  • Reduction of GPER expression in HCC1806 cells after treatment with gefitinib. (A) Concentration dependence. HCC1806 cells were treated with 50-500 nM gefitinib for 48 h. GPER was detected by western blotting. (B) Time dependence. HCC1806 cells were treated with 200 nM gefitinib for 24-96 h. ap<0.05 vs. control; bp<0.001 vs. control. Mean values and SE of three independent experiments are shown. (C) Representative western blotting of concentration dependence. (D) Representative western blotting of time dependence

    Oncol Rep, 2017, 37(2):1212-1218. Gefitinib (ZD1839) purchased from Selleck.

    Inhibition of signaling pathway activation in lung tumor cell lines by kinase inhibitors. Lung tumor cells were cultured in 10% FBS until reaching ∼80% confluence and then the cells were starved in serum-free medium for overnight, followed by 4-hour treatment with the inhibitors. Cell lysates were then prepared and used for determination of the pathway activation signals by the CEER assay.

    Int J Proteomics 2011 215496. Gefitinib (ZD1839) purchased from Selleck.

  • Breast cancer cells were pretreated with 100ng/ml EGF for 15 min and then treated with the indicated concentrations of  Gefitinib for 24 hours.

     

     

    2010 Dr. Zhang of Tianjin Medical University. Gefitinib (ZD1839) purchased from Selleck.

    MTT assay result. 0-500nM Gefitinib treated with H1299, H358, H25 and HCC827 cell lines by 72h, Proliferation rate was tested.

     

     

    2010 Dr. Vicky Tin from University of Hong Kong. Gefitinib (ZD1839) purchased from Selleck.

产品安全说明书

EGFR抑制剂选择性比较

生物活性

产品描述 Gefitinib (ZD1839)是一种EGFR抑制剂,作用于NR6wtEGFR和NR6W细胞中的Tyr1173,Tyr992,Tyr1173和Tyr992,IC50 分别为37 nM,37nM,26 nM和57 nM。
特性 Gefitinib是有效的EGFR酪氨酸激酶抑制剂。
靶点
Tyr1173 (NR6W cells) [1] Tyr1173 (NR6wtEGFR cells) [1] Tyr992 (NR6wtEGFR cells) [1] Tyr992 (NR6W cells) [1]
26 nM 37 nM 37 nM 57 nM
体外研究

Gefitinib 作用于高和低表达EGFR的细胞系,包括NR6, NR6M 和 NR6W 细胞系,有效抑制EGFR上全部酪氨酸磷酸化位点。磷酸化位点 Tyr1173和Tyr992敏感性较低,需要高浓度Gefitinib才能抑制。Gefitinib作用于NR6W细胞,高效阻断PLC-γ磷酸化, IC50为27nM。NR6wtEGFR 和NR6M细胞系具有低水平PLC-γ磷酸化, IC50 分别为 43 nM和 369 nM。Gefitinib抑制AKT磷酸化,作用于低EGFR和EGFRvIII表达的细胞系, IC50 分别为220 和263nM。Gefitinib按 0.1 到 0.5μM剂量处理,显著促进而不是废除 NR6M细胞形成集落。然而, 2μM Gefitinib 完全抑制 NR6M 集落形成。Gefitinib 作用于高和低EGFR表达的细胞系,EGF 刺激72小时后,快速抑制EGFR 和ERK 磷酸化,这种作用存在剂量依赖性。[1]Gefitinib抑制 EGF驱动的未转化MCF10A 细胞生长,IC50为 20 nM。[2] Gefitinib 作用于MDA-MB-231细胞,抑制EGF信号。Gefitinib严重抑制细胞数的增多,这种作用存在剂量依赖性。 [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KB MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHYeJZzUUN3ME2wMlA2PCEQvF2= MoPjNVY2OTZ2N{O=
NIH3T3 NInCTolHfW6ldHnvckBCe3OjeR?= NID1UI8xNjJizszN NWP4WJQ3OiCq MnzVSG1UVw>? MXvJcohq[mm2aX;uJI9nKEWJRjDzeIlufWyjdHXkJIh2dWGwIHXyZmIyKGG3dH;wbI9{eGixconsZZRqd25id3n0bEBKSzVyIH;mJFAvODF2NDFOwG0> NUD2Om95OTZ2OECyPFQ>
COS7 M2P1c2Z2dmO2aX;uJGF{e2G7 M{jIV|k3KM7:TR?= NEPwWJdKdmirYnn0bY9vKG:oIHj1cYFvKEqDS{KgWlYyP0ZibYX0ZY51KGW6cILld5Nm\A>? NHfyc28yPzF5OEeyNi=>
A549 MnrWR5l1d3SxeHnjJGF{e2G7 MX[5OkBp M1zP[2ROW09? NGjZXIRKSzVyPUGzMlU6KM7:TR?= NX;KPHpvOTh|MUO4NFc>
K562 NU[4SZlLS3m2b4TvfIlkKEG|c3H5 MXW5OkBp MnfiSG1UVw>? MnXOTWM2OD17LkO2JO69VQ>? NFTGNXAyQDNzM{iwOy=>
MDA-MB-231 M{PWNmN6fG:2b4jpZ{BCe3OjeR?= MoL5PVYhcA>? NVj4fXZ{TE2VTx?= NXSwWnpXUUN3ME2zOk43OSEQvF2= NXyyS|ZvOTh|MUO4NFc>
MOLT4 NWfQTnd5S3m2b4TvfIlkKEG|c3H5 M4[4Ulk3KGh? NXu0OoRsTE2VTx?= NXvBWlZ{UUN3ME2xOU4xOiEQvF2= M{PCfFE5OzF|OEC3
MCF7 MVTDfZRwfG:6aXOgRZN{[Xl? MnvjOVAh|ryP M{\Pd|czKGh? Mny5TWM2OD1zMj6wOUDPxE1? NVPCSFR6OTh5N{G4NVk>
BT474 NH:0foVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIG0OlQ4OiCq NEDkPG1CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFLUOFc1KGOnbHzzJI93\XKneIDy[ZN{cW6pIFXSRoIzKHerdHigSWM2OCCxZjCwMlMh|ryP NVz2ZVNQOTlyMki0NlQ>
HN5 M1zKPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rH[FczKGh? MojjRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKTkWgZ4VtdHNib4\ldoV5eHKnc4PpcochTUeIUjD3bZRpKEWFNUCgc4YhOC5yMTFOwG0> M333S|E6ODJ6NEK0
BA/F3 NYnmSoljS3m2b4TvfIlkKEG|c3H5 NXHhcWVIPzJiaB?= NU\3N|NkS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhSkFxRkOgZ4VtdHNiZYjwdoV{e2mwZzDFS2ZTKEx6NUjSJI12fGGwdDD3bZRpKEmFNUCgc4YhOC5yMUC4JO69VQ>? MoSzNVkzOzl{Mkm=
NIH3T3 MmrYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrJelE4OiCq NETzNYJIem:5dHigbY5pcWKrdHnvckBw\iCvb4Xz[UBPUUhxM2SzJINmdGy|IHX4dJJme3Orbneg[ZJDOiCpZX7lJJdqfGhiSVO1NEBw\iByLkW0JO69VQ>? MmrvNVk3PjV|N{e=
MCF7 MX MUjGeY5kfGmxbjDBd5NigQ>? MnzvN|AhdWmw NVj5XZozUW6qaXLpeIlwdiCxZjDCR3JRKGW6cILld5Nm\CC5aYToJGlEPTBib3[gNU4yKM7:TR?= NHTxVIgyQTl|Mkm2NC=>
A431 NIewZZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TzV|ExKM7:TR?= MnyxO|IhcA>? MlfoS2k2OD1yLkWxOEDPxE1? MWSxPVk3QTR4NR?=
A431 Mn6yT4lv[XOnIFHzd4F6 M1e2TlAvOSEQvF2= NFPXT4EyKGh? Mn7pTY5pcWKrdHnvckBw\iCHR1[tbY5lfWOnZDDFS2ZTKHCqb4PwbI9zgWyjdHnvci=> M4LrXFE6QTZ7NE[1
A431 Mlv1T4lv[XOnIFHzd4F6 NEHQ[JoyODBizszN M4XhO|ExKG2rbh?= MYTQdo9td26pZXSgbY5pcWKrdH;yfUBi[3Srdnn0fUBw\iCHR1[tbY5lfWOnZDDFS2ZTKHCqb4PwbI9zgWyjdHnvci=> MYexPVk3QTR4NR?=
Sf9 M2\zTmtqdmG|ZTDBd5NigQ>? NWTSVJlpOTBibXnu NV7lVFB1TE2VTx?= MlvtTY5pcWKrdHnvckBw\iCHR1\SJIV5eHKnc4Pl[EBie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJJm[2WydH;yJIF2fG:yaH;zdIhwenmuYYTpc44hf2m2aDDJR|UxKG:oIECuNFM{KM7:TR?= MlrDNlAxPTZ2MkW=
NCI-H1975 NHfv[INIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXS1JO69VQ>? MVO3NkBp NXz6WlNPUUN3ME24MlI3KM7:TR?= NEfKWmgzODF3MU[3NC=>
NCI-H1975 NWnLc|FVU2mwYYPlJGF{e2G7 M1TQTVExKM7:TR?= NUj6PHlKUW6qaXLpeIlwdiCxZjDFS2ZTKGG3dH;wbI9{eGixconsZZRqd25? NXfGOmlbOjBzNUG2O|A>
NCI-H1975 NFn3fGNHfW6ldHnvckBCe3OjeR?= Ml3tNVAh|ryP NY\xUGxWUW6qaXLpeIlwdiCxZjDFVmJDOiCjdYTvdIhwe3Cqb4L5cIF1cW:w M4\YWlIxOTVzNkew
NCI-H1975 NFqxc4pHfW6ldHnvckBCe3OjeR?= Mlf0OUDPxE1? M1LK[FQ5KGh? NX3SNHN{UW6mdXP0bY9vKG:oIHHwc5B1d3OrczDhd5Nme3OnZDDhd{Bi[3SrdnH0bY9vKG:oIHPhd5Bie2VvMx?= MXOyNFE2OTZ5MB?=
A375 NHjMNoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV31RXRFPDhiaB?= MWXJR|UxRTJyLkW1JO69VQ>? NF;qVlczODNyNEWzOy=>
SMMC7721 NX70SnNkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUH4e2NxPDhiaB?= NUXVdWhPUUN3ME2zN{4yOiEQvF2= NEC5OHozODNyNEWzOy=>
DU145 NHHL[mZEgXSxdH;4bYMhSXO|YYm= MnTNOUBl NE\D[GdFVVOR NECzeppKSzVyPUSyMlE4KM7:TR?= M{nIOlIxPDZ4NUW1
MIAPaCa2 MoL4R5l1d3SxeHnjJGF{e2G7 NYHWb|ZtPSCm NWjsZY93TE2VTx?= MlzhTWM2OD13MD62NkDPxE1? NILTRlAzODR4NkW1OS=>
PANC1 MoDkR5l1d3SxeHnjJGF{e2G7 NHnqUIw2KGR? NUPpS2s3TE2VTx?= NYroO3NkUUN3ME20NE41OiEQvF2= NV65Wo1DOjB2Nk[1OVU>
PC9 NH\UTHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LHcWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgSWdHWi2mZX\pZ4lmdnRiaIXtZY4hWEN7IHPlcIx{KHerdHigSWM2OCCxZjCwMlAyPyEQvF2= MUmyNVIxQDhyMh?=
PC9 NEPHblZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPjRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDndo94fGhvcnXzbZN1[W62IHj1cYFvKFCFOTDj[YxteyCneIDy[ZN{cW6pIFXHSnIhTTd2Nm;BO|UxN1R5OUDNJI12fGGwdDD3bZRpKEWFNUCgc4YhPyEQvF2= M1LRfFIyOjB6OECy
PC3 M{LNbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW[xNEDPxE1? M4rwfVczKGh? MnHqSG1UVw>? M125RWlEPTB;Nz60JO69VQ>? MkT4NlE{PTN3NE[=
MDA-MB-468 NXrKW|RZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7BeGUyODBizszN M2CxUFQ5KGh? NVHM[XJNTE2VTx?= MnjlRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdIm= MWiyNVQzQTZ|Mh?=
Plasmodium falciparum NIjLcpFyUFSVIIDyc4ZqdGmwZzDmc5IhcW6qaXLpeI9zeyCxZjDQcIF{dW:maYXtJIZidGOrcHHyeY0heHKxbHnm[ZJifGmxbh?= MWqyNVgyPzB2NR?=
NCI-H1993 NG\MfmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvaWpl1PzJiaB?= MojNSG1UVw>? NFzFWZlKSzVyPUCuNUDPxE1? M3v0dlIyQTF4NEOz
NCI-H292 NHHVN3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1Oyd|czKGh? NUPWUnJNTE2VTx?= NWTjXpdpUUN3ME2wMlAzKM7:TR?= NYX3OXpbOjF7MU[0N|M>
A431 MlS2T4lv[XOnIFHzd4F6 NInwbVAzKGh? NGDC[G9FVVOR NXu0Sm5PUW6qaXLpeIlwdiCxZjDFS2ZTKHCqb4PwbI9zgWyjdHnvckBqdiCHR1[td5RqdXWuYYTl[EBpfW2jbjDBOFMyKHerdHigTWM2OCCxZjCwMlAxOSEQvF2= MmHWNlIyODFzM{K=
MCF7 NF\YcHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fWU|ExOMLizsznM41N MVG0PEBp M1HmSGROW09? M3LKc2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDveoVz\XiycnXzd4lv\yCHR1\SJIdmdmVid3n0bEBKSzVyIH;mJFEzNjB3IN88US=> NIjWTnUzOjFzOUGzNC=>
BT474 MUDDfZRwfG:6aXOgRZN{[Xl? MkHVNVAh|ryP MX:0PEBp MWTDfZRwfG:6aXPpeJkh[WejaX7zeEB{\XK3bT3zeIFzfmWmIHj1cYFvKEKWNEe0JINmdGy| MVeyNlE{QDNyOB?=
MCF7 MnqwR5l1d3SxeHnjJGF{e2G7 MmTVNVAh|ryP NFvaU4c1QCCq MYPDfZRwfG:6aXPpeJkh[WejaX7zeEB{\XK3bT3zeIFzfmWmIHj1cYFvKE2FRkegZ4VtdHNib4\ldk1mgHC{ZYPzbY5oKEW{YlKyJINmdGy| NWP3ToIxOjJzM{izNFg>
HCC827 NWnxNWJKU2mwYYPlJGF{e2G7 NWPxSW03OC5zMkWg{txO NYC4V3BIOjRiaB?= Mk\oSG1UVw>? NFi2T2FKdmirYnn0bY9vKG:oIFXHSnIh\GWuIFW3OFYuSTd3MDDteZRidnRiWUGwOlgh[XW2b4Doc5NxcG:{eXzheIlwdg>? MV2yNlM{QTN2Mh?=
HCC827 MVXLbY5ie2ViQYPzZZk> MnzWNE4yOjVizszN NHTvO5UzPCCq M4P3b2ROW09? NXvBSGtrUW6qaXLpeIlwdiCxZjDFS2ZTKGSnbDDFO|Q3NUF5NUCgcZV1[W62LX3l[IlifGWmIFXyb{BxcG:|cHjvdplt[XSrb36= MnP4NlI{Ozl|NEK=
HCC827 MmS2T4lv[XOnIFHzd4F6 MYKwMlEzPSEQvF2= M1H1SlI1KGh? Moe1SG1UVw>? MoPlTY5pcWKrdHnvckBw\iCHR1\SJIRmdCCHN{S2MWE4PTBibYX0ZY51NW2nZHnheIVlKEGtdDDwbI9{eGixconsZZRqd25? M37CeVIzOzN7M{Sy
A431 NHLWU4pMcW6jc3WgRZN{[Xl? NVHHOGprOTByIN88US=> MWWzNEBucW5? NGO4UHZKdmirYnn0bY9vKG:oIFXHSnIh\GW{aY\l[EBnem:vIHj1cYFvKEF2M{GgZ4VtdCCvZX3idoFv\SCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHCxbImtS4x2NVS7cjDwbI9{eGixconsZZRqd25id3n0bEBKSzVyIH;mJFEvODhizszN MnnaNlI3QTh5OEK=
H460 Mk\FR5l1d3SxeHnjJGF{e2G7 M4fhW|czKGh? MnfhTWM2OD13LkW5JO69VQ>? MX6yNlczPzR2OR?=
HT-29 MVHDfZRwfG:6aXOgRZN{[Xl? NILCRlM4OiCq NF7vcpdKSzVyPUOuN|Yh|ryP M4jxbFIzPzJ5NES5
SGC7901 NEHx[ZZEgXSxdH;4bYMhSXO|YYm= NVr1S4FFPzJiaB?= M4XOUWlEPTB;MUCuNlYh|ryP Mk\ZNlI4Ojd2NEm=
A498 MlPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7uUXZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG0PVgh[2WubIOg[ZhxemW|c3nu[{BGT0[UIHHu[EBUWkNid3n0bEBKSzVyIH;mJFgvPiEQvF2= NGD4eIQzOjhzOEi0PC=>
Calu3 NG\1[VZEgXSxdH;4bYMhSXO|YYm= MkLGNVAh|rypL33M NGe1bok4OiCq NUG3ZWsyUUN3ME2xMlYh|ryP MXKyN|EyPjF4OB?=
FADU NYfae4psS3m2b4TvfIlkKEG|c3H5 MUixNEDPxGdxbVy= NXzXWXNZPzJiaB?= NXWycXZYUUN3ME2wMlA2KM7:TR?= NYHjXVBuOjNzMU[xOlg>
HCC827 NXP5RYxyS3m2b4TvfIlkKEG|c3H5 NFTRV3gyOCEQvHevcWw> MXS3NkBp M2\MemlEPTB;MD6wNFE2KM7:TR?= NEnUTnYzOzFzNkG2PC=>
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BT-20 MnjOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2j3[mlEPTB;Mj6yOlc1PCEQvF2= NVW3ZYVTW0GQR1XS
A498 MoG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUWyNFJCUUN3ME2yMlI6PDF3IN88US=> Ml7IV2FPT0WU
IGROV-1 M4\vfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTJwM{GyN|ch|ryP MUXTRW5ITVJ?
JVM-3 NHW4b2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mme3TWM2OD1{LkO0OlQ{KM7:TR?= M{DtWnNCVkeHUh?=
NCI-H2170 M13FN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWOyRZQzUUN3ME2yMlM1Pzh|IN88US=> MnzjV2FPT0WU
EW-18 NVe0RZQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DtN2lEPTB;Mj6zOVQ4OSEQvF2= M4i2SnNCVkeHUh?=
KU812 NVfySFl{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWOxUnZIUUN3ME2yMlM3Pzd7IN88US=> M{KzZ3NCVkeHUh?=
NY Ml6yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDtclFKSzVyPUKuN|czPyEQvF2= MUjTRW5ITVJ?
HTC-C3 NIPhOYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTJwNEKyOlch|ryP NVuy[HZYW0GQR1XS
CFPAC-1 NHHTboJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;HTWM2OD1{LkSzPFY1KM7:TR?= M1vUSnNCVkeHUh?=
HH NXi2VJFUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\0dolQUUN3ME2yMlQ6QDV2IN88US=> MUPTRW5ITVJ?
MKN7 M37p[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3O1N2lEPTB;Mj62Nlc1QCEQvF2= NX20XYxyW0GQR1XS
TE-8 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\xcGlEPTB;Mj62N|Y2OyEQvF2= NYXEOY5jW0GQR1XS
MC-IXC M2LFfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYntOlVpUUN3ME2yMlY1PDV|IN88US=> MXHTRW5ITVJ?
DMS-79 NWnue|RnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTJwNkmyPFQh|ryP MnHwV2FPT0WU
Detroit562 NG[1SnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYK3SopVUUN3ME2yMlY6QDR3IN88US=> MmTUV2FPT0WU
HuP-T4 MnTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHNTWM2OD1{LkeyPFE5KM7:TR?= Ml[zV2FPT0WU
QIMR-WIL MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rWPGlEPTB;Mj63OVk2OiEQvF2= M33vfHNCVkeHUh?=
BB65-RCC NXnxRnVnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml64TWM2OD1{LkiwO|E{KM7:TR?= MmDCV2FPT0WU
PC-3 NXrqVFVIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTJwOEOzNVch|ryP NEXBe|lUSU6JRWK=
OVCAR-3 NWf2cFg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3uwUGlEPTB;Mj64OVU6PCEQvF2= NH\nfIhUSU6JRWK=
KYSE-510 NWjRWIh4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnwTWM2OD1{Lki2O|g3KM7:TR?= MkSwV2FPT0WU
HC-1 M3HhSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2iyOGlEPTB;Mj65OFAyOiEQvF2= NH7ZdlFUSU6JRWK=
NCI-H1693 Ml;IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vEeGlEPTB;Mj65OVg6PyEQvF2= NW\SSZZJW0GQR1XS
DU-4475 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fHeWlEPTB;Mj65PVA2OiEQvF2= NGf0ZZZUSU6JRWK=
COLO-680N MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPQcYtKSzVyPUOuNFA1QTVizszN NGC3[pBUSU6JRWK=
MN-60 MlnZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;XR2Z1UUN3ME2zMlA1QTd2IN88US=> M{\uUnNCVkeHUh?=
BCPAP MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPTUY9UUUN3ME2zMlA5Ojl3IN88US=> NYnlVoYyW0GQR1XS
647-V NHTISXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTNwMU[yNkDPxE1? M1W1O3NCVkeHUh?=
HT-1376 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTNwMkC1NFYh|ryP NEXQXlhUSU6JRWK=
NCI-H1793 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LBW2lEPTB;Mz6yNVA6QCEQvF2= NIXuWVVUSU6JRWK=
SW1463 M3LieWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHuSWFKSzVyPUOuNlYyQTJizszN MlvjV2FPT0WU
NCI-H727 NV7qR49wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rJNmlEPTB;Mz6zPFU5PCEQvF2= NIP2VVFUSU6JRWK=
LB771-HNC M{LkSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoSwTWM2OD1|LkO5NVI3KM7:TR?= MXTTRW5ITVJ?
D-542MG NIHSbYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnGdYN3UUN3ME2zMlQ1OjJ{IN88US=> NYrnWFJ2W0GQR1XS
NTERA-S-cl-D1 M3\YWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnjXGU3UUN3ME2zMlQ1QTV5IN88US=> MoXQV2FPT0WU
C8166 NGjvUHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PLWGlEPTB;Mz60OlUzOSEQvF2= MYDTRW5ITVJ?
639-V NVG2OpJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXnOpl{UUN3ME2zMlU4Pzl{IN88US=> M1jrVXNCVkeHUh?=
TE-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnrUm5QUUN3ME2zMlU6OTZ7IN88US=> M1S2enNCVkeHUh?=
OAW-28 NX\iend2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\GTWM2OD1|LkW5OFI3KM7:TR?= NVjmW5VoW0GQR1XS
SK-LU-1 NF;4S2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTNwNkC2OFUh|ryP NIHLdHdUSU6JRWK=
CaR-1 M4XPWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3Tic2lEPTB;Mz62NVA1QCEQvF2= NVnENHk3W0GQR1XS
A2780 M1f3[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonXTWM2OD1|Lk[0NFg6KM7:TR?= NHzpTWxUSU6JRWK=
C2BBe1 M2\lc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLTTWM2OD1|Lk[0OFA4KM7:TR?= M{O3NnNCVkeHUh?=
SK-MES-1 NIPKNmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TLbGlEPTB;Mz62OFYyPCEQvF2= NIK4SmRUSU6JRWK=
PANC-10-05 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LLO2lEPTB;Mz63NlA4OiEQvF2= MUjTRW5ITVJ?
J-RT3-T3-5 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLqU4xKSzVyPUOuO|U1ODZizszN M{TMVXNCVkeHUh?=
ES4 M3rIe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWP0UYoyUUN3ME2zMlgzOjh4IN88US=> MXXTRW5ITVJ?
NCI-H28 MoH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DjS2lEPTB;Mz64Nlk3OSEQvF2= MWjTRW5ITVJ?
NCI-H1155 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\UTWlEPTB;Mz64OFE2QSEQvF2= NHvlWpNUSU6JRWK=
KURAMOCHI NIjEXW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTNwOE[wOVYh|ryP MY\TRW5ITVJ?
NCI-H69 MnjlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnP3TWM2OD1|LkmwNVc5KM7:TR?= M4PwUHNCVkeHUh?=
IST-MES1 NHLP[llIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXOTWM2OD1|Lkm0NFI6KM7:TR?= NXuyT|k{W0GQR1XS
NH-12 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3LWXBHUUN3ME2zMlk1OTh5IN88US=> NG\oV|ZUSU6JRWK=
JVM-2 M1LxO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4KyNGlEPTB;Mz65OFc2OiEQvF2= Ml[2V2FPT0WU
EW-16 NUTDdmdKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTGb29yUUN3ME2zMlk2PTd5IN88US=> NHfiTVJUSU6JRWK=
NCI-H441 NUHrS|J6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XqWWlEPTB;Mz65O|AyPCEQvF2= NES4bHdUSU6JRWK=
RCC10RGB MmLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVS1dFgxUUN3ME20MlAyOjR4IN88US=> M{[4[HNCVkeHUh?=
TCCSUP MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnS5TWM2OD12LkGxNFUh|ryP MkXIV2FPT0WU
HL-60 NGKxN2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mln0TWM2OD12LkGyNlQyKM7:TR?= M2XkdnNCVkeHUh?=
EW-11 MoLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{L5[mlEPTB;ND6xN|I3OSEQvF2= MU\TRW5ITVJ?
KARPAS-299 M1ThTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrsTWM2OD12LkOxNFE{KM7:TR?= MYjTRW5ITVJ?
SNU-C2B NIPE[FlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jWWWlEPTB;ND6zOFY5PiEQvF2= NF[zNIpUSU6JRWK=
LU-139 MoLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTsNG1FUUN3ME20MlM4OjR5IN88US=> MX;TRW5ITVJ?
HCC1937 NVXiUFlkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LKPWlEPTB;ND6zO|k6OyEQvF2= M1XhSnNCVkeHUh?=
GR-ST MknrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTRwNEOxPEDPxE1? MnLvV2FPT0WU
SK-OV-3 M{Hkdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jKUWlEPTB;ND60OlA1OiEQvF2= M17ocnNCVkeHUh?=
A172 M{CyfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvFZ3VsUUN3ME20MlU2PTJzIN88US=> MVTTRW5ITVJ?
NB10 NVrrRlJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jmU2lEPTB;ND61PVc5OSEQvF2= NXL1bJVjW0GQR1XS
P30-OHK MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1ixOWlEPTB;ND64NVkzQSEQvF2= MV\TRW5ITVJ?
KYSE-520 NFHYeJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkflTWM2OD12Lki4NFE5KM7:TR?= M1PqSnNCVkeHUh?=
KNS-62 NGS0V|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfDV25tUUN3ME20MlkxQDB5IN88US=> NEfabIJUSU6JRWK=
ES1 M1TYcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvETWM2OD12Lkm2NFM2KM7:TR?= MnPnV2FPT0WU
KOSC-2 MkfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHa[3FKSzVyPUSuPVk6PTlizszN M3Pwb3NCVkeHUh?=
TE-9 M3PWcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLrTWM2OD13LkCxOVI2KM7:TR?= MXjTRW5ITVJ?
NCI-H1838 M3TSe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXxTWM2OD13LkCyNFc3KM7:TR?= NXLaNWN6W0GQR1XS
KP-N-YN NF7CXIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3X1emlEPTB;NT6xNlU6OSEQvF2= MVrTRW5ITVJ?
ALL-PO NHS5[WRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\Qd2lEPTB;NT6yNlU5PyEQvF2= Ml70V2FPT0WU
NOMO-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn63TWM2OD13LkKzNVc3KM7:TR?= MXXTRW5ITVJ?
CGTH-W-1 Mme4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTVwM{i1PFQh|ryP MVrTRW5ITVJ?
ATN-1 Mlq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGm0fJlKSzVyPUWuOFEyQDRizszN NX;3c3VVW0GQR1XS
AGS NXPhTnh5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTtTWM2OD13LkS5OlE5KM7:TR?= NX3MR5psW0GQR1XS
SW13 M4POO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn[2TWM2OD13LkWzNlY2KM7:TR?= MYDTRW5ITVJ?
SW1990 NXjJSZpXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHlSVFWUUN3ME21MlYzOjh3IN88US=> NVT0N4pyW0GQR1XS
BFTC-905 M4[xcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2C3ZmlEPTB;NT62OVg4QCEQvF2= NEnpeYFUSU6JRWK=
RMG-I MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnn1TWM2OD13Lk[1PVQzKM7:TR?= NYXiS4JDW0GQR1XS
HD-MY-Z NH;EepZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TQV2lEPTB;NT62PFU5OSEQvF2= M{DuXXNCVkeHUh?=
HCC1187 M3XZfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEW1eVVKSzVyPUWuO|ExOzJizszN NWDYdHJrW0GQR1XS
HCC2998 NH7EbVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jBWWlEPTB;NT63NVg4PyEQvF2= M{nnbnNCVkeHUh?=
RT-112 MlS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDmTJBjUUN3ME21MlkxOjR3IN88US=> MmX3V2FPT0WU
CAKI-1 NEn0WWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXrTWM2OD14LkCwPVg2KM7:TR?= NYLMZWhJW0GQR1XS
HDLM-2 MlfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LMN2lEPTB;Nj6wNVQ5QSEQvF2= M{jIZnNCVkeHUh?=
TE-10 M3XrdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHa[WxKSzVyPU[uNFQ5OzNizszN M{\vRnNCVkeHUh?=
KE-37 NETKWFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXy1XFA6UUN3ME22MlA4OjV6IN88US=> MU\TRW5ITVJ?
RCM-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XtU2lEPTB;Nj6wO|cyQSEQvF2= MljwV2FPT0WU
Mewo NVGyOotnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;5eFBGUUN3ME22MlEyPDh5IN88US=> M1fnOHNCVkeHUh?=
L-428 MkXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVS2WXFlUUN3ME22MlE5ODN5IN88US=> M{ftbXNCVkeHUh?=
8-MG-BA M{jVbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTZwMUmzO|kh|ryP MYDTRW5ITVJ?
SK-MEL-28 M1WxXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPKU|BKSzVyPU[uNlA6PjdizszN Ml3kV2FPT0WU
VA-ES-BJ NX\tfWdVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;MSmlEPTB;Nj6zNFQ3OiEQvF2= NIXl[ldUSU6JRWK=
CAL-120 NVLs[YlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWn3OoZjUUN3ME22MlQ2OTZ{IN88US=> MX;TRW5ITVJ?
GAMG NIHGcoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\GTWM2OD14LkWwOlIh|ryP Mn7iV2FPT0WU
MSTO-221H NHHadplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnOTIRiUUN3ME22MlUyOTdizszN MVfTRW5ITVJ?
GCT NF7FdmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTZwNUOzPFch|ryP M1LI[nNCVkeHUh?=
SH-4 NXnmUlBST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn31TWM2OD14LkW4PFQ1KM7:TR?= NXiyeXV5W0GQR1XS
Calu-3 NVXqNVNvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LxdGlEPTB;Nj62OVU3QCEQvF2= MmP5V2FPT0WU
SK-HEP-1 M3;tTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvyTWM2OD14LkexO|U{KM7:TR?= MlHwV2FPT0WU
PFSK-1 NWPDe3dIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInzR|lKSzVyPU[uO|M1PzhizszN MUjTRW5ITVJ?
NB12 NITLe3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTZwN{i0NFQh|ryP M2TuTnNCVkeHUh?=
A388 MlzLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzCTWM2OD14Lki5OVIh|ryP NH\UfJNUSU6JRWK=
KLE M4GydGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE[4THJKSzVyPU[uPVY2OTZizszN M17abHNCVkeHUh?=
TE-11 NET3T4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHESINKSzVyPUeuNFQ6PjdizszN NEiyUoZUSU6JRWK=
NCI-H2405 MnnZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XyRWlEPTB;Nz6wPFM6OyEQvF2= NEDSWIxUSU6JRWK=
OVCAR-4 NEPkUpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjITWM2OD15LkG1N|Uh|ryP MXPTRW5ITVJ?
KP-N-YS M3zBO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDkdYxKSzVyPUeuNVgyPCEQvF2= MnjoV2FPT0WU
NOS-1 NYjaSY4zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPpTWM2OD15LkK1PFI5KM7:TR?= MnK2V2FPT0WU
DMS-114 M1XydGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3oTW01UUN3ME23MlI6PjNzIN88US=> NGnjSXZUSU6JRWK=
NCI-H2030 NWPPWW5oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnCTWM2OD15LkOzOlk5KM7:TR?= Mo\sV2FPT0WU
HEL MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1G3Z2lEPTB;Nz6zO|UzOSEQvF2= NGjvfItUSU6JRWK=
CAL-62 NEe3W4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTdwM{m4OlYh|ryP M320[HNCVkeHUh?=
COLO-668 NVrNV|V2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzKTWM2OD15LkSzPVY4KM7:TR?= M4LFXXNCVkeHUh?=
SKG-IIIa MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVv1XYlnUUN3ME23MlQ2OzhzIN88US=> NGfZO5NUSU6JRWK=
HCC1419 MkHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWiycFNzUUN3ME23MlQ3QDN|IN88US=> NV;qSpFGW0GQR1XS
OS-RC-2 NIjRR|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmD0TWM2OD15LkS5PFk1KM7:TR?= MoT1V2FPT0WU
COLO-829 NXPhSY9NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLyTWM2OD15Lk[2OFY{KM7:TR?= MWLTRW5ITVJ?
NB13 NWrSRpNNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfPTlZrUUN3ME23MlgzPjZ5IN88US=> MXvTRW5ITVJ?
DK-MG MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTdwOEOyNFEh|ryP Ml3SV2FPT0WU
SHP-77 M3TOU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fpbWlEPTB;Nz64OlY2OyEQvF2= M{fVSnNCVkeHUh?=
NCI-H661 M4LmVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nwOmlEPTB;OD6wOVg3PyEQvF2= Mnm4V2FPT0WU
AM-38 NYXwSphWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTuTnRjUUN3ME24MlE3OjhizszN MkLHV2FPT0WU
VM-CUB-1 NHv5NGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\DVZVKSzVyPUiuNVcxOjlizszN M36xO3NCVkeHUh?=
KYSE-70 NH7TemdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\HXW1FUUN3ME24MlE6PzZzIN88US=> Mk\lV2FPT0WU
5637 NHP3dFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRThwM{GwOVUh|ryP MmPrV2FPT0WU
TGBC11TKB Mln6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHq3c4pKSzVyPUiuOFYyPjRizszN NIW1bYNUSU6JRWK=
EGI-1 MlX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkKzTWM2OD16Lk[wNFg5KM7:TR?= M2j2RXNCVkeHUh?=
D-392MG MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrVV4xSUUN3ME24MlY3OjF2IN88US=> MkexV2FPT0WU
A673 M3npeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRThwNke2NVEh|ryP MkjvV2FPT0WU
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NCI-H1792 NXrqXHZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWe1WmFLUUN3ME24Mlg5QTB|IN88US=> M1iwc3NCVkeHUh?=
LS-1034 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLhOW9LUUN3ME24Mlk1PjV{IN88US=> NXz3OlRCW0GQR1XS
D-566MG Ml3CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTlwMEG4NUDPxE1? M175bXNCVkeHUh?=
NCI-H226 NHfvdJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn:wTWM2OD17LkC5JO69VQ>? NE[xeopUSU6JRWK=
ChaGo-K-1 M3;Yd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHvTWM2OD17LkGwOVc6KM7:TR?= MWLTRW5ITVJ?
NCI-H2228 NHOxPZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XDS2lEPTB;OT6xNVA5OSEQvF2= MXvTRW5ITVJ?
RPMI-8226 NHPCNXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn65TWM2OD17LkGxN|A1KM7:TR?= MUnTRW5ITVJ?
BFTC-909 NHLLNoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjTUHRMUUN3ME25MlE5Ojl5IN88US=> NHzMOIJUSU6JRWK=
HPAF-II NEPtU2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYizcm1nUUN3ME25MlIzPTF6IN88US=> NEDQbWxUSU6JRWK=
Capan-2 NVHQflJjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYi3WFVOUUN3ME25MlQxOTB7IN88US=> NXnhdIJbW0GQR1XS
IA-LM MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVn3elYyUUN3ME25MlQyQTZ4IN88US=> NV;TXGFQW0GQR1XS
KP-4 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTVTWM2OD17LkS4PFM5KM7:TR?= MkLnV2FPT0WU
A101D NHez[W5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnnTWM2OD17LkWxO|E6KM7:TR?= NHi2c5ZUSU6JRWK=
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SW837 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPSTWM2OD17Lki0PFIh|ryP Mn3CV2FPT0WU
OCI-AML2 Mn7rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX24e5E6UUN3ME25Mlg3QTZizszN MYrTRW5ITVJ?
NCI-H1355 NFHOepJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTlwOUSwPFgh|ryP NIjU[ItUSU6JRWK=
NCI-H2342 NGDYTY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLqTWM2OD1zMD6wNVU2KM7:TR?= MXXTRW5ITVJ?
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CAL-51 MnPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PQ[2lEPTB;MUCuNFg4PyEQvF2= M1H5W3NCVkeHUh?=
HCE-4 NXPReW5DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTFyLkGxNlIh|ryP M3Trb3NCVkeHUh?=
NCI-H810 NXi3UllbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDlTWM2OD1zMD6xOVk4KM7:TR?= MnzPV2FPT0WU
DJM-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXzcGRKSzVyPUGwMlE4OzJizszN MWLTRW5ITVJ?
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D-336MG MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnsfFJKSzVyPUGwMlcxODVizszN MnzTV2FPT0WU
LXF-289 NGLEZ3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjQSYkxUUN3ME2xNE44QTZ5IN88US=> MVPTRW5ITVJ?
SW900 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDVbWhCUUN3ME2xNE45OjJ6IN88US=> NYPPO|dCW0GQR1XS
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LB831-BLC MoDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXOWWhFUUN3ME2xNU4zPTV4IN88US=> MUnTRW5ITVJ?
FTC-133 M4XQR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTFzLkOwPFEh|ryP M2rtWXNCVkeHUh?=
HCC1954 NH\FcY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4P2O2lEPTB;MUGuOFM3KM7:TR?= MVLTRW5ITVJ?
GOTO MonZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTFzLkWyNFYh|ryP MYDTRW5ITVJ?
LS-411N NHXVfXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33MSmlEPTB;MUGuOlExOSEQvF2= MULTRW5ITVJ?
RPMI-7951 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEL3UGhKSzVyPUGxMlY{PDhizszN MnvqV2FPT0WU
NCI-H1299 NYnCbYUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTFzLk[2OFch|ryP MkLPV2FPT0WU
MLMA M1H4[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HTSmlEPTB;MUGuOlk6PyEQvF2= M134T3NCVkeHUh?=
MMAC-SF NHLmXoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPzenlKSzVyPUGxMlczPTJizszN M4PDNnNCVkeHUh?=
UM-UC-3 Mmr6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17ifWlEPTB;MUGuO|QzOSEQvF2= MUPTRW5ITVJ?
SCC-9 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTFzLkixOVEh|ryP M1TwUnNCVkeHUh?=
HOS MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDtSVJKSzVyPUGxMlg3QDNizszN NISw[I1USU6JRWK=
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Mo-T MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTkTWM2OD1zMT65OVQyKM7:TR?= NXnybll1W0GQR1XS
CAMA-1 NEe5VJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTF{LkG2N|Mh|ryP MmK2V2FPT0WU
U-118-MG NH3tN45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrZTWM2OD1zMj6yOFQyKM7:TR?= MYDTRW5ITVJ?
KS-1 MnvmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTF{LkK4N|Ih|ryP NHfSTYhUSU6JRWK=
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ABC-1 MkHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M173UmlEPTB;MUKuN|QyKM7:TR?= M1vHenNCVkeHUh?=
Daoy NHvDV4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTF{LkS1OFIh|ryP NHuyZWpUSU6JRWK=
C3A MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPlTWM2OD1zMj61O|g2KM7:TR?= M{jRXnNCVkeHUh?=
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RH-18 NGnC[JZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jUe2lEPTB;MUOuNlk3OiEQvF2= M3fDSnNCVkeHUh?=
SN12C NUP1WmxMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVq2U4w2UUN3ME2xN{4{QDB6IN88US=> NFrnXnZUSU6JRWK=
NCI-H1993 Mnq3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfMTWM2OD1zMz60Nlg2KM7:TR?= MlzDV2FPT0WU
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SK-PN-DW MkL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrCTWV7UUN3ME2xN{45PDJ5IN88US=> NWGw[GR1W0GQR1XS
KALS-1 MnLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfQcnNKSzVyPUGzMlg2OjVizszN M1qxNXNCVkeHUh?=
LAN-6 NXLIXFFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DONGlEPTB;MUSuNlU{KM7:TR?= M4Xhd3NCVkeHUh?=
A549 NIO0XllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTF2LkS3NVIh|ryP NUnMN4tQW0GQR1XS
RD NFnpTJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnmdVJQUUN3ME2xOE41QDF|IN88US=> NV63d|Y5W0GQR1XS
TGBC1TKB MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;1TWM2OD1zND62OlE2KM7:TR?= MUDTRW5ITVJ?
NCI-H630 M3;oTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljhTWM2OD1zND65OFY4KM7:TR?= NYjhXYVoW0GQR1XS
MIA-PaCa-2 MlTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYKxcG1jUUN3ME2xOE46PjlizszN NFW3UoNUSU6JRWK=
NCI-H1755 Mn7QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFWzWlVKSzVyPUG0Mlk6PTNizszN MV3TRW5ITVJ?
MOLT-4 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnP1TWM2OD1zNT6wOFk4KM7:TR?= MYTTRW5ITVJ?
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MPP-89 Mmq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTF3Lkm0NVch|ryP MXnTRW5ITVJ?
HT55 NXexRoNWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3ke|RKSzVyPUG1Mlk1PzhizszN NH7kVJJUSU6JRWK=
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GP5d NIXmUopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPqTndSUUN3ME2xOk4zOTh5IN88US=> M{TNXXNCVkeHUh?=
BHT-101 NXf1[VJTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHzeoRKSzVyPUG2MlI1OzlizszN NVnlN5FmW0GQR1XS
M059J M{\tOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4j2NGlEPTB;MU[uNlg1KM7:TR?= MnnNV2FPT0WU
D-283MED M2C3dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTF4LkSyNFkh|ryP NUXabFZ{W0GQR1XS
BEN M1G4cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXZV5RZUUN3ME2xOk42OTV3IN88US=> MUHTRW5ITVJ?
LB373-MEL-D NF\TcYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zFNWlEPTB;MU[uO|I{OiEQvF2= M1PkVnNCVkeHUh?=
MEL-HO Mn7TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHGwdIZKSzVyPUG2Mlg5PTRizszN M2rrbXNCVkeHUh?=
GI-ME-N M2fwVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXr4b3RVUUN3ME2xOk46ODN{IN88US=> NYn3PHJ{W0GQR1XS
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NCI-H1573 NULzcXZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTF5LkK4NlYh|ryP MnnTV2FPT0WU
NCI-H1581 NEHpeHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NECwUJRKSzVyPUG3MlQ1OTFizszN M2jldHNCVkeHUh?=
NCI-H747 NIXRNJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDJTWM2OD1zNz61Nlk4KM7:TR?= MojFV2FPT0WU
SW1783 M{DVVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPWd2x{UUN3ME2xO{43PDF3IN88US=> NX7FV3M5W0GQR1XS
Calu-6 NFOxRZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTF5Lk[3PFIh|ryP M2LhN3NCVkeHUh?=
SF268 M3Lld2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HHRWlEPTB;MUeuOlk3QSEQvF2= MUPTRW5ITVJ?
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SW626 M2PUc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\NfWlEPTB;M{euNFQyPyEQvF2= MYnTRW5ITVJ?
ONS-76 NX7reJEyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXOTWM2OD1|Nz6xN|A6KM7:TR?= M4jwcnNCVkeHUh?=
T98G M33SPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\5XmlEPTB;M{euPFY{PSEQvF2= MoLKV2FPT0WU
NB14 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3jTWM2OD1|OD60OVQ1KM7:TR?= NGm5fopUSU6JRWK=
D-423MG M{\5N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzHRVNVUUN3ME2zPE41QDZ7IN88US=> MV3TRW5ITVJ?
NCI-H510A M4izTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XCNmlEPTB;M{iuOlQ2OSEQvF2= MXHTRW5ITVJ?
NMC-G1 Mn7zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XDOWlEPTB;M{iuO|IzOiEQvF2= NEHoWJNUSU6JRWK=
SW948 MlXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;GPFRuUUN3ME2zPE45QTR7IN88US=> NWTKTGpVW0GQR1XS
MFM-223 MkHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfxe|hJUUN3ME2zPE46PDNzIN88US=> NVG4OGhLW0GQR1XS
PAN1 NEi1c4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTN6Lkm5NVkh|ryP M4KzbHNCVkeHUh?=
MZ7-mel NUPP[4h5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXBZWhKSzVyPUO5MlEyQTlizszN NYHlSI1TW0GQR1XS
COLO-679 NXTTTW5OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HMV2lEPTB;M{muPVcxQCEQvF2= M1Xib3NCVkeHUh?=
SW872 NHLBfGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTRyLkKwN|Eh|ryP M2mxe3NCVkeHUh?=
HT-1197 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3nTlJKSzVyPUSwMlI5PjlizszN M2LNeHNCVkeHUh?=
ES6 M2DZ[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fQbGlEPTB;NECuOFU2OiEQvF2= Mme2V2FPT0WU
SNU-387 MmSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH20ZmpKSzVyPUSwMlgzOzhizszN NYf5eGloW0GQR1XS
T47D NEHLW4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXkVFZKSzVyPUSxMlAyQTJizszN NXfSRXgxW0GQR1XS
G-402 NUO0dWt[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHmzbGpKSzVyPUSxMlA5ODlizszN NGrkdYlUSU6JRWK=
MZ1-PC MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEWwNHVKSzVyPUSxMlgyKM7:TR?= MX3TRW5ITVJ?
SW1417 NFXnZ3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnZTWM2OD12Mj6zNFMh|ryP MVLTRW5ITVJ?
RERF-LC-MS NGjqUoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlS0TWM2OD12Mj61NFg4KM7:TR?= NGPoXnpUSU6JRWK=
SF539 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PYR2lEPTB;NEKuOVUzQSEQvF2= MWLTRW5ITVJ?
ESS-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XWRWlEPTB;NEOuOVU2QCEQvF2= NH;qZ3NUSU6JRWK=
RO82-W-1 NYPxR5NLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTR|Lk[xOVMh|ryP MV\TRW5ITVJ?
S-117 Ml;0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITpdIpKSzVyPUSzMlY6PThizszN NFP6XHhUSU6JRWK=
SW756 NVLtOo9FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfBTWM2OD12Mz64NlQzKM7:TR?= MWXTRW5ITVJ?
CP66-MEL NE\WTJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LWXWlEPTB;NEWuO|E1OyEQvF2= NF24fm1USU6JRWK=
H-EMC-SS NH7wR3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGG3[5RKSzVyPUS1Mlc3QTNizszN M3TnUHNCVkeHUh?=
NCI-H2052 NWTUO3RsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTOU5dxUUN3ME20OU46ODJ5IN88US=> NWXn[5RbW0GQR1XS
SW684 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDITWM2OD12Nz6wNFgyKM7:TR?= NWDHblIxW0GQR1XS
HCC1569 NUToW29mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHWd|RSUUN3ME20O{4yPjV6IN88US=> NXv1WmV4W0GQR1XS
KGN MoHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3ocIR{UUN3ME20O{4{OzFzIN88US=> MkjCV2FPT0WU
LCLC-103H MoXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XSdmlEPTB;NEeuOFQxPCEQvF2= NXf1fmQ6W0GQR1XS
SW780 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTR5Lk[zOVEh|ryP M2X4bnNCVkeHUh?=
NCI-H1703 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7D[pdKSzVyPUS4MlM{PTJizszN NHXHWVRUSU6JRWK=
HCC1395 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHX6PINKSzVyPUS4Mlc1OzJizszN NV7xSIY2W0GQR1XS

... Click to View More Cell Line Experimental Data

体内研究 Gefitinib 作用于无胸腺裸鼠,抑制SKOV3 或MDA-MB-231 肿瘤生长。Gefitinib高效作用于两种类型肿瘤。处理14天后,MDA-MB-231肿瘤和SKOV3肿瘤生长抑制分别为71%和32%。

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:[1]
+ 展开
  • Cell lines: NR6, NR6M 和 NR6W 细胞
  • Concentrations: 0 μM -2 μM
  • Incubation Time: 72 小时
  • Method: 呈指数生长的细胞,包括 NR6, NR6M, NR6M和NR6W细胞按6倍接种在96孔板上,每孔为2000个细胞, 粘附,随后在PBS 中清洗,然后在含0.5% FCS的培养基上温育过夜。使用不同浓度(0-2 μM) Gefitinib或溶质对照DMSO 和EGF 处理细胞。诱导NR6wtEGFR和NR6W 细胞增殖的EGF最佳浓度已经测定,因此NR6wtEGFR和 NR6W 细胞中分别加入10 nM和 0.1 nM EGF。NR6 和NR6M细胞中不加入EGF。72 小时后,通过MTT 增殖检测测量细胞数。
    (Only for Reference)
动物实验:[3]
+ 展开
  • Animal Models: 携带 SKOV3或MDA-MB-231肿瘤的无胸腺裸鼠
  • Formulation: 0.2% DMSO
  • Dosages: 75 mg/kg
  • Administration: 饲喂处理
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 89 mg/mL (199.14 mM)
Ethanol 4 mg/mL (8.95 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
1% CMC Na
30mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 446.90
化学式

C22H24ClFN4O3

CAS号 184475-35-2
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03866499 Not yet recruiting NSCLC Beta Pharma Inc. May 2019 Phase 3
NCT03866499 Not yet recruiting NSCLC Beta Pharma Inc. May 2019 Phase 3
NCT03787992 Not yet recruiting Locally Advanced or Metastatic EGFR Sensitising Mutation Positive Non-small Cell Lung Cancer Allist Pharmaceuticals Inc. April 1 2019 Phase 3
NCT03787992 Not yet recruiting Locally Advanced or Metastatic EGFR Sensitising Mutation Positive Non-small Cell Lung Cancer Allist Pharmaceuticals Inc. April 1 2019 Phase 3
NCT03766490 Not yet recruiting Non-Small-Cell Lung The First Affiliated Hospital of Soochow University|The First People''s Hospital of Changzhou|Second Affiliated Hospital of Soochow University|Nantong University|Affiliated Hospital of Jiangnan University|Jiangyin People''s Hospital|Changzhou No.2 People''s Hospital|Chia Tai Tianqing Pharmaceutical Group Co. Ltd. March 30 2019 Not Applicable
NCT03856697 Not yet recruiting Advanced Non-small Cell Lung Cancer Hangzhou ACEA Pharmaceutical Research Co. Ltd.|Guangdong Provincial People''s Hospital March 2019 Phase 3

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    I try to dissolve Gefitinib (ZD1839) in 0.5% methylcellulose+0.2% Tween 80 for in vivo experiments. However, when I prepare the mixture, it forms precipitates. Exists another way to dissolve completely the compound?

  • 回答:

    S1025 can be dissovled in both 5% DMSO+corn oil and 5% DMSO+30% PEG 300+5% Tween 80+ddH2O at 2.5 mg/ml clearly. It dissolves in DMSO not readily, please sonicate and warm it in water bath at about 45 degree, and dissolve it clearly first. Then add other solvent.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID