Gefitinib (ZD1839)

For research use only. Not for use in humans.

目录号：S1025 别名： Iressa 中文名称：吉非替尼

CAS No. 184475-35-2

Gefitinib (ZD1839)是一种EGFR抑制剂，作用于NR6wtEGFR和NR6W细胞中的Tyr1173、Tyr992、Tyr1173和Tyr992，IC50 分别为37 nM、37nM、26 nM和57 nM。Gefitinib 可通过阻滞PI3K/AKT/mTOR信号通路来促进肺癌细胞的自噬和细胞凋亡。

规格

价格

库存

购买数量

10mM (1mL in DMSO)	RMB 1574.78	现货
100mg	RMB 1227.69	现货
250mg	RMB 2205.98	现货
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客户使用Selleck生产的Gefitinib (ZD1839)发表文献514篇：

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Lipids Health Dis, 2013, 12:101

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Exp Mol Pathol, 2013, 94(2):386-97

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Evid Based Complement Alternat Med, 2013, 2013:243859

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J Genet Syndr Gene Ther, 2013, 4

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Herpesviridae, 2013, 4(1):1

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产品安全说明书

EGFR抑制剂选择性比较

生物活性

产品描述

特性

Gefitinib是有效的EGFR酪氨酸激酶抑制剂。

靶点

Tyr1173 (NR6W cells) ^[1]	Tyr1173 (NR6wtEGFR cells) ^[1]	Tyr992 (NR6wtEGFR cells) ^[1]	Tyr992 (NR6W cells) ^[1]
26 nM	37 nM	37 nM	57 nM

体外研究

Gefitinib 作用于高和低表达EGFR的细胞系，包括NR6, NR6M 和 NR6W 细胞系，有效抑制EGFR上全部酪氨酸磷酸化位点。磷酸化位点 Tyr1173和Tyr992敏感性较低，需要高浓度Gefitinib才能抑制。Gefitinib作用于NR6W细胞，高效阻断PLC-γ磷酸化, IC50为27nM。NR6wtEGFR 和NR6M细胞系具有低水平PLC-γ磷酸化， IC50 分别为 43 nM和 369 nM。Gefitinib抑制AKT磷酸化，作用于低EGFR和EGFRvIII表达的细胞系， IC50 分别为220 和263nM。Gefitinib按 0.1 到 0.5μM剂量处理，显著促进而不是废除 NR6M细胞形成集落。然而, 2μM Gefitinib 完全抑制 NR6M 集落形成。Gefitinib 作用于高和低EGFR表达的细胞系，EGF 刺激72小时后，快速抑制EGFR 和ERK 磷酸化，这种作用存在剂量依赖性。^[1]Gefitinib抑制 EGF驱动的未转化MCF10A 细胞生长，IC50为 20 nM。^[2] Gefitinib 作用于MDA-MB-231细胞，抑制EGF信号。Gefitinib严重抑制细胞数的增多，这种作用存在剂量依赖性。 ^[3]

Cell Data

Cell Lines	Assay Type	Activity Description	PMID
NCI-H1975	M3HoZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXzzTXlWUUN3ME2yNU41PjFizszN	NIDQfFk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6OzlxJ{7TRW5ITVJ:L3G+
HT	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUXJR\|UxRTJzLkSzN\|Eh\|ryP	MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5N\|kwLz6VQV7HSXI9N2F-
HUTU-80	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3izbmlEPTB;MkGuOFM{PiEQvF2=	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5N\|kwLz6VQV7HSXI9N2F-
PA-1	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{HDemlEPTB;MkGuNlc5PyEQvF2=	NYiwb2JlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTN7Lze+V2FPT0WUPD;hQi=>
HOP-62	MoSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2ntUmlEPTB;MkGuNlc5PCEQvF2=	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5N\|kwLz6VQV7HSXI9N2F-
GI-1	M1LnXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVPO[lhsUUN3ME2yNU4yPyEQvF2=	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5N\|kwLz6VQV7HSXI9N2F-
MC116	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnjsTWM2OD1{MT6wO\|I{KM7:TR?=	NYrxRpVIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTN7Lze+V2FPT0WUPD;hQi=>
A375	NHjPV3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1jpXGlEPTB;MkGuNFU3PyEQvF2=	M2jJU\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk{QS9pPmPBUmdGWjxxYU6=
IST-SL1	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWjJR\|UxRTJyLke4O\|kh\|ryP	Mmf4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVM6Nyd-U1HOS2VTRC:jPh?=
TE-5	MmDLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYPJR\|UxRTJyLke0PFIh\|ryP	M3;2W\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk{QS9pPmPBUmdGWjxxYU6=
SiHa	M4LLdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1rGdGlEPTB;MkCuN\|cyOiEQvF2=	NV:2PYlWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTN7Lze+V2FPT0WUPD;hQi=>
LB2518-MEL	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NU\xdoE{UUN3ME2yNE4{PzN7IN88US=>	M{D2OlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk{QS9pPmPBUmdGWjxxYU6=
BB49-HNC	Mom2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3vvZ2lEPTB;MUmuPVIh\|ryP	M{G4PVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk{QS9pPmPBUmdGWjxxYU6=
HGC-27	MlHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1vYN2lEPTB;MkCuNVM6PCEQvF2=	MoG5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVM6Nyd-U1HOS2VTRC:jPh?=
Becker	NEHpSVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWLJR\|UxRTF7Lki1OFch\|ryP	NVnzS3NyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTN7Lze+V2FPT0WUPD;hQi=>
TYK-nu	NYrRfWlqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1TTPWlEPTB;MUmuPFM4QCEQvF2=	MnjCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVM6Nyd-U1HOS2VTRC:jPh?=
NCI-H650	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnnQTWM2OD1zOT63OVA5KM7:TR?=	MmX1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVM6Nyd-U1HOS2VTRC:jPh?=
WM-115	NXXHbYxOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWXrd2pnUUN3ME2xPU43Pzd2IN88US=>	NFrKcHY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6OzlxJ{7TRW5ITVJ:L3G+
HuH-7	NEK3bpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVX2PJNiUUN3ME2xPU44PDJzIN88US=>	M4rENFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk{QS9pPmPBUmdGWjxxYU6=
NCI-N87	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVP6UFJIUUN3ME2xPU42QTl{IN88US=>	NXPGb4pFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTN7Lze+V2FPT0WUPD;hQi=>
NCI-H1048	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXjJR\|UxRTF7LkKzNlYh\|ryP	Mn;OQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVM6Nyd-U1HOS2VTRC:jPh?=
NCI-H446	NWXuUGVuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3XETmlEPTB;MUmuN\|U5QSEQvF2=	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5N\|kwLz6VQV7HSXI9N2F-
NCI-H1437	M4HHc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Ml;QTWM2OD1zOT6wOFY4KM7:TR?=	NULXVVI4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTN7Lze+V2FPT0WUPD;hQi=>
D-263MG	NF3jTXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NX7SOYFVUUN3ME2xPU4xOTd{IN88US=>	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5N\|kwLz6VQV7HSXI9N2F-
MFH-ino	NYXXNopKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUL6WFdzUUN3ME2xPE46PjZ7IN88US=>	MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5N\|kwLz6VQV7HSXI9N2F-
U-266	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFXxbVlKSzVyPUG4Mlg3PDlizszN	NEnDVYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6OzlxJ{7TRW5ITVJ:L3G+
OVCAR-8	NEjwZpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoDBTWM2OD1zOD65Nlc3KM7:TR?=	NY\LPGdpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTN7Lze+V2FPT0WUPD;hQi=>
KNS-42	NXjiem5ZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NV\JSFV5UUN3ME2xPE45ODF3IN88US=>	M17TUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk{QS9pPmPBUmdGWjxxYU6=
U251	M2DYS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3XPdGlEPTB;MUiuO\|M1PyEQvF2=	MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5N\|kwLz6VQV7HSXI9N2F-
MFE-280	NVLaSJdbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWTaRYJsUUN3ME2xPE44Ojl\|IN88US=>	NH64dGI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6OzlxJ{7TRW5ITVJ:L3G+
NCI-H1563	M1jZSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHi1S5JKSzVyPUG4MlcyOjRizszN	Mm\zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVM6Nyd-U1HOS2VTRC:jPh?=
MDA-MB-361	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlLKTWM2OD1zOD61OVg5KM7:TR?=	NUDsdI1NRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTN7Lze+V2FPT0WUPD;hQi=>
HLE	NFXYeJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NE\YeGZKSzVyPUG4MlMyPDhizszN	NHj4dJE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6OzlxJ{7TRW5ITVJ:L3G+
SW982	NYnEeFdiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUPJR\|UxRTF6LkSwO\|Uh\|ryP	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5N\|kwLz6VQV7HSXI9N2F-
KM-H2	M{XHVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MknFTWM2OD1zNz65OFEyKM7:TR?=	NVXHWGJGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTN7Lze+V2FPT0WUPD;hQi=>
D-502MG	M1izbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnHHTWM2OD1zNz65PFA5KM7:TR?=	Mk\WQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVM6Nyd-U1HOS2VTRC:jPh?=
ES8	NWnUXpJkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4rqfmlEPTB;MUeuPFU6OyEQvF2=	MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5N\|kwLz6VQV7HSXI9N2F-
SF268	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXfDdlFLUUN3ME2xO{43QTZ7IN88US=>	NEfzWII9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6OzlxJ{7TRW5ITVJ:L3G+
Calu-6	MnHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NU\obIFCUUN3ME2xO{43Pzh{IN88US=>	NV;oW45ORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTN7Lze+V2FPT0WUPD;hQi=>
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