Gefitinib (ZD1839)

目录号:S1025

Gefitinib (ZD1839) Chemical Structure

Molecular Weight(MW): 446.90

Gefitinib (ZD1839)是一种EGFR抑制剂,作用于NR6wtEGFR和NR6W细胞中的Tyr1173,Tyr992,Tyr1173和Tyr992,IC50 分别为37 nM,37nM,26 nM和57 nM。

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客户购买Selleck的此次产品后发表的文献93篇:

客户使用该产品的14个实验数据:

  • c, HCC4006 lung cancer cells that have acquired a high-mesenchymal state concomitant with becoming resistant to gefitinib (red curve) exhibit increased sensitivity to GPX4 inhibition.

    Nature, 2017, 547(7664):453-457. Gefitinib (ZD1839) purchased from Selleck.

    Perturbation of EGFR by its ligand EGF and gefitinib (ZD-1839 Iressat; inhibits EGFR) produces opposite responses in the predicted EGFR target genes SOCS2 and NR2E1.

    Mol Syst Biol 2011 7, 486. Gefitinib (ZD1839) purchased from Selleck.

  • Effects of shRNA-mediated RECK depletion on EGFR signaling in MEFs. (a) Immunoblotting (IB) of the indicated proteins in wild-type MEFs transduced with the indicated shRNAs and cultured for 48 h in the presence of 0.1% dimethyl sulfoxide (DMSO; vehicle) or 1 mM gefitinib (S1025, Selleck Chemicals,Houston, TX, USA). (b) Immunoprecipitation from whole lysates of cells from panel a with an anti-phosphorylated tyrosine (pTyr) antibody. Precipitates from 500 mg protein in whole cell lysates (upper) or 20 mg protein in whole cell lysates (lower) were analyzed by IB with anti-EGFR antibody.

    Oncogene 2010 30, 737-750. Gefitinib (ZD1839) purchased from Selleck.

    (B–C) LNCaP (B) and LNCaP-AI (C) cells were transiently transfected with sPLA2-IIa(-800)-Luc (0.5 μg). The cells were then treated with Erlotinib (20 μM), Gefitinib (20 μM), Lapatinib (20 μM), CI-1033 (8 μM), LY294002 (20 lM) and Bortezomib (20 μM) without or with EGF (100 ng/ml) for 24 h. Luciferase assay was performed according to a standard protocol with Renilla luciferase as an internal control. Data are presented as the mean (±SD) of duplicate values of a representative experiment that was independently repeated for five times.

    Carcinogenesis 2010 31, 1948–1955 . Gefitinib (ZD1839) purchased from Selleck.

  • LNCaP-AI cells were starved in 1% stripped medium for 24 h. The cells were then treated with Erlotinib (20 μM), Gefitinib (20 μM), Lapatinib (20 μM), CI-1033 (8 μM), LY294002 (20 μM) and Bortezomib (20 μM) for 24 h. Cell culture medium was collected from each sample and subjected to ELISA for sPLA2-IIa. The condition medium samples were diluted 10 times for ELISA. Average of duplicate samples was converted to nanogram per milliliter against standard curve. The data represent one of five repeated experiments.

     

     

    Carcinogenesis 2010 31, 1948–1955. Gefitinib (ZD1839) purchased from Selleck.

    Suppression of EGFR signaling by Gefitinib is dose dependent and non- toxic at millimolar concentrations.Results from plaque reduction tests of Hep2 cells infected with VACV(12.5pfu/well) treated with a serial dilution of Gefitinib (1000-0.01 m) and analyzed for (A)proliferation as indicator of cytotoxicity,(B) IC50 of plaque size inhibition, (C)dose dependent inhibition of EGFR-ERK1/2signaling and VACV proteins by Western blot analysis (pEGFR detection was obtained from a different experiment with identicals ettings) and (D)dose dependent inhibition of orthopoxvirus genome replication by real-time PCR.Untreated VACV infectedcells and uninfected cells are shown as controls in the right panel.

    Antiviral Res 2010 89, 64-70. Gefitinib (ZD1839) purchased from Selleck.

  • A circular zone of EGFR activated but uninfected cells facilitate virus induced plaque development , efficiently blocked by Gefitinib. (A)Immun of luorescent staining of aplaque reduction tests with Hep2 cells 24,48,72 and 96 h after VACV infection (6.25pfu/chamber). VACV infected cells(green) were visualized by human IgG directed to orthopoxviruses (VIG) detected with a secondary FITC labelled antibody. Uninfected cells with activated EGFR signaling(red) are detected with a secondary Cy3labelled antibody. Positive cells for both , VACV and phosphorylated EGFR are shown in yellow(merge). Cellular nuclei are counterstained with DAPI. (B)Immunofluorescent staining of a plaque reduction test as described for (A) and treated with three different Gefitinib concentrations (1000 nM, 1 nM, and 0.01 nM) . The test was analyzed 96h afterVACV infection.Uninfected cells are shown as controls. Magnification100×.(For interpretation of the references to color in this figure legend , the reader is referred to the web version of the article.)

     

     

    Antiviral Res 2010 89, 64-70. Gefitinib (ZD1839) purchased from Selleck.

    Susceptibility of lung cancer cells to cytolytic activity of NK-92 cells after treatment with EGFR inhibitors. Three lung cancer cells were untreated (open circle) or treated with 10 μM erlotinib or gefitinib (black filled square or black filled triangle) for 24 hours. The lung cancer cells were cocultured with NK-92 cells at indicated effector to target ratio (E:T ratio). To determine the specificity of NKG2D-mediated cytolysis of lung cancer cells, NK-92 cells were preincubated with blocking mAb against NKG2D before the assay (gray filled square and triangle) and correspond-ing isotype mAb (open square and triangle).

    J Immunother 2011 34(4), 372-81. Gefitinib (ZD1839) purchased from Selleck.

  • Inhibition of 5-HT-induced 5-HT3A and 5-HT3AB receptor currents.

    Eur J Pharmacol, 2017, 821:21-28. Gefitinib (ZD1839) purchased from Selleck.

    The EGF-dependent increased association of PCM1 and AZI1 requires EGFR kinase activity. ZD1839 (Iressa)—EGFR tyrosine kinase inhibitor.

    Mol Biosyst 2011 7, 3223-33. Gefitinib (ZD1839) purchased from Selleck.

  • Reduction of GPER expression in HCC1806 cells after treatment with gefitinib. (A) Concentration dependence. HCC1806 cells were treated with 50-500 nM gefitinib for 48 h. GPER was detected by western blotting. (B) Time dependence. HCC1806 cells were treated with 200 nM gefitinib for 24-96 h. ap<0.05 vs. control; bp<0.001 vs. control. Mean values and SE of three independent experiments are shown. (C) Representative western blotting of concentration dependence. (D) Representative western blotting of time dependence

    Oncol Rep, 2017, 37(2):1212-1218. Gefitinib (ZD1839) purchased from Selleck.

    Inhibition of signaling pathway activation in lung tumor cell lines by kinase inhibitors. Lung tumor cells were cultured in 10% FBS until reaching ∼80% confluence and then the cells were starved in serum-free medium for overnight, followed by 4-hour treatment with the inhibitors. Cell lysates were then prepared and used for determination of the pathway activation signals by the CEER assay.

    Int J Proteomics 2011 215496. Gefitinib (ZD1839) purchased from Selleck.

  • Breast cancer cells were pretreated with 100ng/ml EGF for 15 min and then treated with the indicated concentrations of  Gefitinib for 24 hours.

     

     

    2010 Dr. Zhang of Tianjin Medical University. Gefitinib (ZD1839) purchased from Selleck.

    MTT assay result. 0-500nM Gefitinib treated with H1299, H358, H25 and HCC827 cell lines by 72h, Proliferation rate was tested.

     

     

    2010 Dr. Vicky Tin from University of Hong Kong. Gefitinib (ZD1839) purchased from Selleck.

产品安全说明书

EGFR抑制剂选择性比较

生物活性

产品描述 Gefitinib (ZD1839)是一种EGFR抑制剂,作用于NR6wtEGFR和NR6W细胞中的Tyr1173,Tyr992,Tyr1173和Tyr992,IC50 分别为37 nM,37nM,26 nM和57 nM。
特性 Gefitinib是有效的EGFR酪氨酸激酶抑制剂。
靶点
Tyr1173 (NR6W cells) [1] Tyr1173 (NR6wtEGFR cells) [1] Tyr992 (NR6wtEGFR cells) [1] Tyr992 (NR6W cells) [1]
26 nM 37 nM 37 nM 57 nM
体外研究

Gefitinib 作用于高和低表达EGFR的细胞系,包括NR6, NR6M 和 NR6W 细胞系,有效抑制EGFR上全部酪氨酸磷酸化位点。磷酸化位点 Tyr1173和Tyr992敏感性较低,需要高浓度Gefitinib才能抑制。Gefitinib作用于NR6W细胞,高效阻断PLC-γ磷酸化, IC50为27nM。NR6wtEGFR 和NR6M细胞系具有低水平PLC-γ磷酸化, IC50 分别为 43 nM和 369 nM。Gefitinib抑制AKT磷酸化,作用于低EGFR和EGFRvIII表达的细胞系, IC50 分别为220 和263nM。Gefitinib按 0.1 到 0.5μM剂量处理,显著促进而不是废除 NR6M细胞形成集落。然而, 2μM Gefitinib 完全抑制 NR6M 集落形成。Gefitinib 作用于高和低EGFR表达的细胞系,EGF 刺激72小时后,快速抑制EGFR 和ERK 磷酸化,这种作用存在剂量依赖性。[1]Gefitinib抑制 EGF驱动的未转化MCF10A 细胞生长,IC50为 20 nM。[2] Gefitinib 作用于MDA-MB-231细胞,抑制EGF信号。Gefitinib严重抑制细胞数的增多,这种作用存在剂量依赖性。 [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KB NIPhdJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TkSmlEPTB;MD6wOVQh|ryP MmPYNVY2OTZ2N{O=
NIH3T3 MkTFSpVv[3Srb36gRZN{[Xl? NIm0bGExNjJizszN MYeyJIg> NHrFNXBFVVOR MknqTY5pcWKrdHnvckBw\iCHR1[gd5RqdXWuYYTl[EBpfW2jbjDldoJDOSCjdYTvdIhwe3Cqb4L5cIF1cW:wIIfpeIghUUN3MDDv[kAxNjBzNESg{txO NGr0NWwyPjR6MEK4OC=>
COS7 M3H1SmZ2dmO2aX;uJGF{e2G7 MXq5OkDPxE1? NX7pWm1mUW6qaXLpeIlwdiCxZjDoeY1idiCMQVuyJHY3OTeIIH31eIFvfCCneIDy[ZN{\WR? M1:3OlE4OTd6N{Ky
A549 NIHEW4JEgXSxdH;4bYMhSXO|YYm= NWLmUllNQTZiaB?= Mnj1SG1UVw>? NXmxZ21NUUN3ME2xN{42QSEQvF2= NYTuOmdvOTh|MUO4NFc>
K562 MV7DfZRwfG:6aXOgRZN{[Xl? M1W5b|k3KGh? NF\t[mtFVVOR NUm5VItbUUN3ME25MlM3KM7:TR?= MUOxPFMyOzhyNx?=
MDA-MB-231 Ml;6R5l1d3SxeHnjJGF{e2G7 M1nodFk3KGh? NH21Z2ZFVVOR M2fLXGlEPTB;M{[uOlEh|ryP MkXsNVg{OTN6MEe=
MOLT4 MmTGR5l1d3SxeHnjJGF{e2G7 MXK5OkBp MWnEUXNQ M{DKVGlEPTB;MUWuNFIh|ryP M3;wdVE5OzF|OEC3
MCF7 Mk[4R5l1d3SxeHnjJGF{e2G7 M3q1dFUxKM7:TR?= MWm3NkBp MXvJR|UxRTF{LkC1JO69VQ>? MlPNNVg4PzF6MUm=
BT474 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEf1XW84OiCq MVLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEKWNEe0JINmdGy|IH;2[ZJmgHC{ZYPzbY5oKEWUQnKyJJdqfGhiRVO1NEBw\iByLkOg{txO NUjONIcxOTlyMki0NlQ>
HN5 NHrjfpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrCSHA4OiCq M{\Oc2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSF61JINmdGy|IH;2[ZJmgHC{ZYPzbY5oKEWJRmKge4l1cCCHQ{WwJI9nKDBwMEGg{txO NFXQSIIyQTB{OESyOC=>
BA/F3 M3;MbmN6fG:2b4jpZ{BCe3OjeR?= NGHsVVU4OiCq MoTMR5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgRmEwTjNiY3XscJMh\XiycnXzd4lv\yCHR1\SJGw5PTiUIH31eIFvfCC5aYToJGlEPTBib3[gNE4xOTB6IN88US=> MnLGNVkzOzl{Mkm=
NIH3T3 M3z5Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTkO|IhcA>? M1;lZWdzd3e2aDDpcohq[mm2aX;uJI9nKG2xdYPlJG5KUC9|VEOgZ4VtdHNiZYjwdoV{e2mwZzDldmIzKGenbnWge4l1cCCLQ{WwJI9nKDBwNUSg{txO NX31ZnJZOTl4NkWzO|c>
MCF7 MX MoLHSpVv[3Srb36gRZN{[Xl? NWfIZXpxOzBibXnu NXPTb|NTUW6qaXLpeIlwdiCxZjDCR3JRKGW6cILld5Nm\CC5aYToJGlEPTBib3[gNU4yKM7:TR?= NX7y[JhDOTl7M{K5OlA>
A431 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWSxNEDPxE1? NIm1V|I4OiCq NHPyTYtIUTVyPUCuOVE1KM7:TR?= NWXIO4piOTl7Nkm0OlU>
A431 NEWyS|JMcW6jc3WgRZN{[Xl? NFjzU5oxNjFizszN NHzrU2EyKGh? MX;Jcohq[mm2aX;uJI9nKEWJRj3pcoR2[2WmIFXHSnIheGixc4Doc5J6dGG2aX;u M{LpUFE6QTZ7NE[1
A431 M{X2PWtqdmG|ZTDBd5NigQ>? MUCxNFAh|ryP MYqxNEBucW5? M{\rdnBzd2yxbnfl[EBqdmirYnn0c5J6KGGldHn2bZR6KG:oIFXHSk1qdmS3Y3XkJGVITlJicHjvd5Bpd3K7bHH0bY9v M33GXlE6QTZ7NE[1
Sf9 NF;Fc|VMcW6jc3WgRZN{[Xl? NH2zb3MyOCCvaX6= NY[4SlQzTE2VTx?= MlPXTY5pcWKrdHnvckBw\iCHR1\SJIV5eHKnc4Pl[EBie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJJm[2WydH;yJIF2fG:yaH;zdIhwenmuYYTpc44hf2m2aDDJR|UxKG:oIECuNFM{KM7:TR?= MkXVNlAxPTZ2MkW=
NCI-H1975 NHzCcpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYj2[2dZPSEQvF2= NYruTFJsPzJiaB?= MX\JR|UxRThwMk[g{txO NVS5dFVMOjBzNUG2O|A>
NCI-H1975 NFTWUHNMcW6jc3WgRZN{[Xl? NWDXOlE1OTBizszN Mn[yTY5pcWKrdHnvckBw\iCHR1\SJIF2fG:yaH;zdIhwenmuYYTpc44> NVjKd4pbOjBzNUG2O|A>
NCI-H1975 Mki1SpVv[3Srb36gRZN{[Xl? M2fVXFExKM7:TR?= MkDRTY5pcWKrdHnvckBw\iCHUlLCNkBifXSxcHjvd5Bpd3K7bHH0bY9v M4fMSlIxOTVzNkew
NCI-H1975 NVPDfJBWTnWwY4Tpc44hSXO|YYm= M1HOdlUh|ryP NYXtSYh3PDhiaB?= MlrQTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCjc4Pld5Nm\CCjczDhZ5RqfmG2aX;uJI9nKGOjc4Dhd4UuOw>? MlPYNlAyPTF4N{C=
A375 NWXNOJJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUW0PEBp NVHsPINQUUN3ME2yNE42PSEQvF2= MnPXNlA{ODR3M{e=
SMMC7721 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVu0PEBp NIHJNo5KSzVyPUOzMlEzKM7:TR?= NVr1VI1iOjB|MES1N|c>
DU145 NWnkPJlwS3m2b4TvfIlkKEG|c3H5 M{\QRVUh\A>? NVfVcmJSTE2VTx?= NVLFXnduUUN3ME20Nk4yPyEQvF2= MnnlNlA1PjZ3NUW=
MIAPaCa2 MkfxR5l1d3SxeHnjJGF{e2G7 MUm1JIQ> NI\4cJdFVVOR MX;JR|UxRTVyLk[yJO69VQ>? MWeyNFQ3PjV3NR?=
PANC1 NHW3XYtEgXSxdH;4bYMhSXO|YYm= M4Ty[|Uh\A>? Mlr1SG1UVw>? Mlf5TWM2OD12MD60NkDPxE1? NUH0UYtjOjB2Nk[1OVU>
PC9 MkHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XROGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgSWdHWi2mZX\pZ4lmdnRiaIXtZY4hWEN7IHPlcIx{KHerdHigSWM2OCCxZjCwMlAyPyEQvF2= M12wV|IyOjB6OECy
PC9 NWO1[ms5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjEPYR2SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBoem:5dHitdoV{cXO2YX70JIh2dWGwIGDDPUBk\WyuczDlfJBz\XO|aX7nJGVITlJiRUe0On9CPzVyL2S3PVBOKG23dHHueEB4cXSqIFXDOVAhd2ZiNzFOwG0> NFfvTlgzOTJyOEiwNi=>
PC3 M4TXWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jj[lExKM7:TR?= NHr3eWM4OiCq MWHEUXNQ NF\sTodKSzVyPUeuOEDPxE1? M3KxVFIyOzV|NUS2
MDA-MB-468 NUD6cIc5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYWxNFAh|ryP MnywOFghcA>? MYPEUXNQ NEnP[GdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fS=> M1PLSVIyPDJ7NkOy
Plasmodium falciparum NVToNIFreUiWUzDwdo9ncWyrbneg[o9zKGmwaHnibZRwenNib3[gVIxie22xZHn1cUBn[WylaYDhdpVuKHC{b3zp[oVz[XSrb36= M3TGR|IyQDF5MES1
NCI-H1993 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLOO|IhcA>? NV;EVHNnTE2VTx?= M{\qPGlEPTB;MD6xJO69VQ>? NHTyUZIzOTlzNkSzNy=>
NCI-H292 M4C4bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;URlczKGh? M37KdWROW09? NVjOS4pjUUN3ME2wMlAzKM7:TR?= NWq2bnF2OjF7MU[0N|M>
A431 NGfnVlJMcW6jc3WgRZN{[Xl? NGDFUFAzKGh? NVTTVmk5TE2VTx?= NYDlZ|FPUW6qaXLpeIlwdiCxZjDFS2ZTKHCqb4PwbI9zgWyjdHnvckBqdiCHR1[td5RqdXWuYYTl[EBpfW2jbjDBOFMyKHerdHigTWM2OCCxZjCwMlAxOSEQvF2= M3XlZlIzOTBzMUOy
MCF7 NUPKVnd5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nGU|ExOMLizsznM41N NUfERZg6PDhiaB?= MnfWSG1UVw>? NUPTbo1uSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJI93\XKneIDy[ZN{cW6pIFXHSnIh\2WwZTD3bZRpKEmFNUCgc4YhOTJwMEWg{txO NHfrdJczOjFzOUGzNC=>
BT474 Ml7BR5l1d3SxeHnjJGF{e2G7 MXexNEDPxE1? NU\2OlZFPDhiaB?= M2O0d2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KHOncoXtMZN1[XK4ZXSgbJVu[W5iQmS0O|Qh[2WubIO= M3Pi[lIzOTN6M{C4
MCF7 MXrDfZRwfG:6aXOgRZN{[Xl? NYeze5hqOTBizszN MWq0PEBp NXjqeFg5S3m2b4TvfIlkcXS7IHHnZYlve3Ric3XyeY0ue3Sjco\l[EBpfW2jbjDNR2Y4KGOnbHzzJI93\XJvZYjwdoV{e2mwZzDFdoJDOiClZXzsdy=> NYLSTY9COjJzM{izNFg>
HCC827 MWTLbY5ie2ViQYPzZZk> MViwMlEzPSEQvF2= M4fie|I1KGh? MWPEUXNQ NVXk[FYyUW6qaXLpeIlwdiCxZjDFS2ZTKGSnbDDFO|Q3NUF5NUCgcZV1[W62IGmxNFY5KGG3dH;wbI9{eGixconsZZRqd25? MYSyNlM{QTN2Mh?=
HCC827 NFTFUFZMcW6jc3WgRZN{[Xl? M3jMXVAvOTJ3IN88US=> MkXuNlQhcA>? MlXmSG1UVw>? NX7xTIpFUW6qaXLpeIlwdiCxZjDFS2ZTKGSnbDDFO|Q3NUF5NUCgcZV1[W62LX3l[IlifGWmIFXyb{BxcG:|cHjvdplt[XSrb36= MXOyNlM{QTN2Mh?=
HCC827 NEfRfZBMcW6jc3WgRZN{[Xl? M4G2O|AvOTJ3IN88US=> MXeyOEBp MVTEUXNQ M3HHd2lvcGmkaYTpc44hd2ZiRVfGVkBl\WxiRUe0Ok1CPzVyIH31eIFvfC2vZXTpZZRm\CCDa4SgdIhwe3Cqb4L5cIF1cW:w NFKzW|EzOjN|OUO0Ni=>
A431 MUTLbY5ie2ViQYPzZZk> MlrRNVAxKM7:TR?= M1uxXVMxKG2rbh?= NGL3Z4tKdmirYnn0bY9vKG:oIFXHSnIh\GW{aY\l[EBnem:vIHj1cYFvKEF2M{GgZ4VtdCCvZX3idoFv\SCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHCxbImtS4x2NVS7cjDwbI9{eGixconsZZRqd25id3n0bEBKSzVyIH;mJFEvODhizszN M{PvWFIzPjl6N{iy
H460 M2PHRWN6fG:2b4jpZ{BCe3OjeR?= Moe5O|IhcA>? NXn0PVRXUUN3ME21MlU6KM7:TR?= M{PQdFIzPzJ5NES5
HT-29 Mom3R5l1d3SxeHnjJGF{e2G7 NWHwUWJ3PzJiaB?= M{jXW2lEPTB;Mz6zOkDPxE1? M3G0TFIzPzJ5NES5
SGC7901 MlmwR5l1d3SxeHnjJGF{e2G7 MXO3NkBp NWrUTlh1UUN3ME2xNE4zPiEQvF2= NW\0NHNROjJ5Mke0OFk>
A498 NHGxWlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;hSmF5SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOFk5KGOnbHzzJIV5eHKnc4PpcochTUeIUjDhcoQhW1KFIIfpeIghUUN3MDDv[kA5NjZizszN M2HuflIzQDF6OES4
Calu3 MmHjR5l1d3SxeHnjJGF{e2G7 NIjq[oIyOCEQvHevcWw> NYjiXXgzPzJiaB?= M2P2UGlEPTB;MT62JO69VQ>? MYeyN|EyPjF4OB?=
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HCC827 NWX0eohRS3m2b4TvfIlkKEG|c3H5 NVPZWYdFOTBizsznM41N MXi3NkBp Ml:3TWM2OD1yLkCwNVUh|ryP MkLhNlMyOTZzNki=
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SCC-4 Mnr6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXwTWM2OD1{LkKxO|c3KM7:TR?= NYTOdo9LW0GQR1XS
BT-20 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn64TWM2OD1{LkK2O|Q1KM7:TR?= MWLTRW5ITVJ?
A498 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{njPGlEPTB;Mj6yPVQyPSEQvF2= NVzuPG06W0GQR1XS
IGROV-1 NFPMXFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX60WYE1UUN3ME2yMlMyOjN5IN88US=> MXfTRW5ITVJ?
JVM-3 NWW3V|JmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlryTWM2OD1{LkO0OlQ{KM7:TR?= NEWwWlBUSU6JRWK=
NCI-H2170 MorxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHvTWM2OD1{LkO0O|g{KM7:TR?= MnT4V2FPT0WU
EW-18 MmjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zOTWlEPTB;Mj6zOVQ4OSEQvF2= MmCyV2FPT0WU
KU812 M2nPOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXsZZZKSzVyPUKuN|Y4PzlizszN NUX4SoZ4W0GQR1XS
NY NID6Nm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoS4TWM2OD1{LkO3Nlch|ryP M4LGPXNCVkeHUh?=
HTC-C3 NUjxfpIyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfOTWM2OD1{LkSyNlY4KM7:TR?= Mn3RV2FPT0WU
CFPAC-1 MlPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTJwNEO4OlQh|ryP NV;1V457W0GQR1XS
HH NIe3PVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jwZmlEPTB;Mj60PVg2PCEQvF2= NWfUfXlSW0GQR1XS
MKN7 NHi1boJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXDUYJKSzVyPUKuOlI4PDhizszN MkPTV2FPT0WU
TE-8 NGj0U5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUO5TphQUUN3ME2yMlY{PjV|IN88US=> Mn3XV2FPT0WU
MC-IXC Mkm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPvTWM2OD1{Lk[0OFU{KM7:TR?= MVLTRW5ITVJ?
DMS-79 NIXwUGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXtdYpKSzVyPUKuOlkzQDRizszN M4nI[nNCVkeHUh?=
Detroit562 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLuZmFwUUN3ME2yMlY6QDR3IN88US=> NH[4bVZUSU6JRWK=
HuP-T4 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\tTWM2OD1{LkeyPFE5KM7:TR?= NH3IU25USU6JRWK=
QIMR-WIL NHy5cIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnoNplKSzVyPUKuO|U6PTJizszN MW\TRW5ITVJ?
BB65-RCC M1\JZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTJwOEC3NVMh|ryP NVrZXWU3W0GQR1XS
PC-3 M1G3d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVj1Z3JyUUN3ME2yMlg{OzF5IN88US=> MoTIV2FPT0WU
OVCAR-3 NF7VfY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTJwOEW1PVQh|ryP M3vKS3NCVkeHUh?=
KYSE-510 NXrXR3VKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHm5e2lKSzVyPUKuPFY4QDZizszN M2D2WHNCVkeHUh?=
HC-1 NX73c2o{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTJwOUSwNVIh|ryP M3fFZ3NCVkeHUh?=
NCI-H1693 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7rfJB5UUN3ME2yMlk2QDl5IN88US=> MnfpV2FPT0WU
DU-4475 NY\GU4c2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPNTWM2OD1{Lkm5NFUzKM7:TR?= M{XzOXNCVkeHUh?=
COLO-680N M2njd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTNwMEC0PVUh|ryP MmThV2FPT0WU
MN-60 NEnucVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;idGlEPTB;Mz6wOFk4PCEQvF2= Mmf2V2FPT0WU
BCPAP MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{G4W2lEPTB;Mz6wPFI6PSEQvF2= M3\y[HNCVkeHUh?=
647-V NUL5XWg2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TRdWlEPTB;Mz6xOlIzKM7:TR?= MX3TRW5ITVJ?
HT-1376 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jZfGlEPTB;Mz6yNFUxPiEQvF2= MkHFV2FPT0WU
NCI-H1793 NGXuTplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDTPHRKSzVyPUOuNlExQThizszN MonsV2FPT0WU
SW1463 M1S1V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYm0XJRkUUN3ME2zMlI3OTl{IN88US=> M4XpZnNCVkeHUh?=
NCI-H727 MkHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LyUmlEPTB;Mz6zPFU5PCEQvF2= NXXvb5NYW0GQR1XS
LB771-HNC MmfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;oVGlEPTB;Mz6zPVEzPiEQvF2= M{DO[nNCVkeHUh?=
D-542MG Mkj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XV[WlEPTB;Mz60OFIzOiEQvF2= MXLTRW5ITVJ?
NTERA-S-cl-D1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XGOWlEPTB;Mz60OFk2PyEQvF2= M3Xsb3NCVkeHUh?=
C8166 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jHdmlEPTB;Mz60OlUzOSEQvF2= MVHTRW5ITVJ?
639-V NXy1dmtxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17XS2lEPTB;Mz61O|c6OiEQvF2= M4O2NXNCVkeHUh?=
TE-1 MlzzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTNwNUmxOlkh|ryP MYLTRW5ITVJ?
OAW-28 NVO1RZB[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmCxTWM2OD1|LkW5OFI3KM7:TR?= MVzTRW5ITVJ?
SK-LU-1 M1K3R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDYflhKSzVyPUOuOlA3PDVizszN NH3jfYxUSU6JRWK=
CaR-1 NWLmS3RRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnz6TWM2OD1|Lk[xNFQ5KM7:TR?= M1XGOnNCVkeHUh?=
A2780 NFvrVoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEW1ZlhKSzVyPUOuOlQxQDlizszN NYDxSGp4W0GQR1XS
C2BBe1 MkfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\XTWM2OD1|Lk[0OFA4KM7:TR?= MlLxV2FPT0WU
SK-MES-1 NE\udFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnnTWM2OD1|Lk[0OlE1KM7:TR?= NWDUO5F6W0GQR1XS
PANC-10-05 MorGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nHfWlEPTB;Mz63NlA4OiEQvF2= Mk\iV2FPT0WU
J-RT3-T3-5 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTNwN{W0NFYh|ryP MlXxV2FPT0WU
ES4 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUe4[GNUUUN3ME2zMlgzOjh4IN88US=> MoLPV2FPT0WU
NCI-H28 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PJRWlEPTB;Mz64Nlk3OSEQvF2= M1radHNCVkeHUh?=
NCI-H1155 NIDIWmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTNwOESxOVkh|ryP Mn\QV2FPT0WU
KURAMOCHI NE\RWmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTNwOE[wOVYh|ryP MXnTRW5ITVJ?
NCI-H69 NF7iXmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETNWFRKSzVyPUOuPVAyPzhizszN NH;nb2NUSU6JRWK=
IST-MES1 MnjpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTNwOUSwNlkh|ryP MXvTRW5ITVJ?
NH-12 Mni5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4W0XmlEPTB;Mz65OFE5PyEQvF2= M3:5fnNCVkeHUh?=
JVM-2 NUHLXWRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTGTWM2OD1|Lkm0O|UzKM7:TR?= MlntV2FPT0WU
EW-16 NInrZ4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfxNod4UUN3ME2zMlk2PTd5IN88US=> NEfLWlBUSU6JRWK=
NCI-H441 M160Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PKSWlEPTB;Mz65O|AyPCEQvF2= NFPYc4VUSU6JRWK=
RCC10RGB M4PMbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTRwMEGyOFYh|ryP MojvV2FPT0WU
TCCSUP M2T2cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jBXmlEPTB;ND6xNVA2KM7:TR?= MYPTRW5ITVJ?
HL-60 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7FTWM2OD12LkGyNlQyKM7:TR?= MoLhV2FPT0WU
EW-11 NXfKe|E5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXzUYNKSzVyPUSuNVMzPjFizszN NXHmfI9kW0GQR1XS
KARPAS-299 NFq3OIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY[2S3FOUUN3ME20MlMyODF|IN88US=> NXTGNGNuW0GQR1XS
SNU-C2B M1X6b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLhcHBOUUN3ME20MlM1Pjh4IN88US=> Ml\4V2FPT0WU
LU-139 MnjTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknvTWM2OD12LkO3NlQ4KM7:TR?= NGG1TpdUSU6JRWK=
HCC1937 MmDGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTRwM{e5PVMh|ryP MYLTRW5ITVJ?
GR-ST M1vVemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLJO|JKSzVyPUSuOFMyQCEQvF2= NX;5UZFTW0GQR1XS
SK-OV-3 M1jPdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXr2UXFCUUN3ME20MlQ3ODR{IN88US=> M1fubXNCVkeHUh?=
A172 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTRwNUW1NlEh|ryP MnPxV2FPT0WU
NB10 NEOzZpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3WycGlEPTB;ND61PVc5OSEQvF2= NH;xcmdUSU6JRWK=
P30-OHK MkHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTRwOEG5Nlkh|ryP NFXHR29USU6JRWK=
KYSE-520 NGDjXJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fVU2lEPTB;ND64PFAyQCEQvF2= M17UdHNCVkeHUh?=
KNS-62 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFq5[ZFKSzVyPUSuPVA5ODdizszN Ml7SV2FPT0WU
ES1 NHX5UoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXmTWM2OD12Lkm2NFM2KM7:TR?= NVzle3hCW0GQR1XS
KOSC-2 NUSzOm9ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\KTWM2OD12Lkm5PVU6KM7:TR?= NVGw[VdyW0GQR1XS
TE-9 MmTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\4SodKSzVyPUWuNFE2OjVizszN M1zvZ3NCVkeHUh?=
NCI-H1838 M{\BTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXrR2luUUN3ME21MlAzODd4IN88US=> MYfTRW5ITVJ?
KP-N-YN M4HSVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnz1TWM2OD13LkGyOVkyKM7:TR?= M2nGbnNCVkeHUh?=
ALL-PO MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTVwMkK1PFch|ryP NUXzUHpLW0GQR1XS
NOMO-1 NEeye2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\vTWM2OD13LkKzNVc3KM7:TR?= M1\1bXNCVkeHUh?=
CGTH-W-1 NIXmbHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTI[XVVUUN3ME21MlM5PTh2IN88US=> NIrFdFRUSU6JRWK=
ATN-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3K5SmlEPTB;NT60NVE5PCEQvF2= MYfTRW5ITVJ?
AGS M4[zPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIj4dppKSzVyPUWuOFk3OThizszN NWTVTVREW0GQR1XS
SW13 NG\DOFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPmN21KSzVyPUWuOVMzPjVizszN NG\VSGhUSU6JRWK=
SW1990 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnq3TWM2OD13Lk[yNlg2KM7:TR?= NYny[IxSW0GQR1XS
BFTC-905 NUH2ZogxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXrb5VKSzVyPUWuOlU5PzhizszN MUXTRW5ITVJ?
RMG-I M2rNfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DaSWlEPTB;NT62OVk1OiEQvF2= M3rQUHNCVkeHUh?=
HD-MY-Z M2fpd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4ewXWlEPTB;NT62PFU5OSEQvF2= MYjTRW5ITVJ?
HCC1187 NFe2b41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTVwN{GwN|Ih|ryP Mof2V2FPT0WU
HCC2998 MorIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnqbJhKSzVyPUWuO|E5PzdizszN NUfaN2IyW0GQR1XS
RT-112 NX\j[FlRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLDTWM2OD13LkmwNlQ2KM7:TR?= M2DkUHNCVkeHUh?=
CAKI-1 NEj3OmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTZwMEC5PFUh|ryP NITQbGtUSU6JRWK=
HDLM-2 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1y1S2lEPTB;Nj6wNVQ5QSEQvF2= MWHTRW5ITVJ?
TE-10 NWXPS49nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTZwMES4N|Mh|ryP NEPhNGFUSU6JRWK=
KE-37 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETDUZBKSzVyPU[uNFczPThizszN NYnw[WhiW0GQR1XS
RCM-1 MmfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTZwMEe3NVkh|ryP MYnTRW5ITVJ?
Mewo MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\Ge3hKSzVyPU[uNVE1QDdizszN MoLHV2FPT0WU
L-428 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPxcGdKSzVyPU[uNVgxOzdizszN MUnTRW5ITVJ?
8-MG-BA M4fl[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfCTWM2OD14LkG5N|c6KM7:TR?= M3HSbHNCVkeHUh?=
SK-MEL-28 M4W2TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\6XWJPUUN3ME22MlIxQTZ5IN88US=> NW\yS2F5W0GQR1XS
VA-ES-BJ NYH4S4x1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTZwM{C0OlIh|ryP M3j1THNCVkeHUh?=
CAL-120 Mn;lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfNbHNKSzVyPU[uOFUyPjJizszN Mo\HV2FPT0WU
GAMG NHe0S|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHxVoVKSzVyPU[uOVA3OiEQvF2= NIDyfIFUSU6JRWK=
MSTO-221H M2XpZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\MTWM2OD14LkWxNVch|ryP Mle5V2FPT0WU
GCT NGfhOmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LufGlEPTB;Nj61N|M5PyEQvF2= MXfTRW5ITVJ?
SH-4 Mk\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDRTWM2OD14LkW4PFQ1KM7:TR?= M{e5OHNCVkeHUh?=
Calu-3 MoXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fsfGlEPTB;Nj62OVU3QCEQvF2= MmriV2FPT0WU
SK-HEP-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXpcJJKSzVyPU[uO|E4PTNizszN M4Hie3NCVkeHUh?=
PFSK-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfybpZKSzVyPU[uO|M1PzhizszN M4fDXXNCVkeHUh?=
NB12 MnvOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;6SYVVUUN3ME22Mlc5PDB2IN88US=> MmnuV2FPT0WU
A388 NGH1[pVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTZwOEm1NkDPxE1? M3OxeXNCVkeHUh?=
KLE M33nRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTZwOU[1NVYh|ryP NUPKN3RZW0GQR1XS
TE-11 MoXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXab5F3UUN3ME23MlA1QTZ5IN88US=> MWfTRW5ITVJ?
NCI-H2405 MoDxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrDPI5MUUN3ME23MlA5Ozl|IN88US=> MmXjV2FPT0WU
OVCAR-4 M2TSO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTdwMUWzOUDPxE1? M131WXNCVkeHUh?=
KP-N-YS NXPtXI5JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DXXWlEPTB;Nz6xPFE1KM7:TR?= MXXTRW5ITVJ?
NOS-1 NWjCUFlIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTdwMkW4Nlgh|ryP Mkm1V2FPT0WU
DMS-114 MmDMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zSd2lEPTB;Nz6yPVY{OSEQvF2= M3exXnNCVkeHUh?=
NCI-H2030 NWDOSVVQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTdwM{O2PVgh|ryP M1j2fHNCVkeHUh?=
HEL NG\LWohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTdwM{e1NlEh|ryP MmLGV2FPT0WU
CAL-62 NV;h[mVqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW[0fmRYUUN3ME23MlM6QDZ4IN88US=> MmTlV2FPT0WU
COLO-668 MonuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\tVJBUUUN3ME23MlQ{QTZ5IN88US=> MnH5V2FPT0WU
SKG-IIIa NFjBVpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY[zdIM6UUN3ME23MlQ2OzhzIN88US=> M1PRUnNCVkeHUh?=
HCC1419 NFnOZ5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3L6WGlEPTB;Nz60Olg{OyEQvF2= NUPKRYdVW0GQR1XS
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SHP-77 M3rKTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPnWW96UUN3ME23Mlg3PjV|IN88US=> NFT4TlBUSU6JRWK=
NCI-H661 M3rnSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTKRlBJUUN3ME24MlA2QDZ5IN88US=> MnPWV2FPT0WU
AM-38 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRThwMU[yPEDPxE1? MVrTRW5ITVJ?
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EGI-1 NIHNToVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M32wSGlEPTB;OD62NFA5QCEQvF2= MmjBV2FPT0WU
D-392MG M1:yT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;nd2lEPTB;OD62OlIyPCEQvF2= NHnVS4VUSU6JRWK=
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D-566MG MmXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTlwMEG4NUDPxE1? NEHrcHFUSU6JRWK=
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NCI-H630 MkTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHm0do9KSzVyPUG0Mlk1PjdizszN MUnTRW5ITVJ?
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Calu-6 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTF5Lk[3PFIh|ryP MXXTRW5ITVJ?
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ONS-76 NF\iT2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\DS2lEPTB;M{euNVMxQSEQvF2= NHXLS5hUSU6JRWK=
T98G NWLMfW8yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\6TWM2OD1|Nz64OlM2KM7:TR?= NWjHPVJ[W0GQR1XS
NB14 MlPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fFemlEPTB;M{iuOFU1PCEQvF2= NF3le5hUSU6JRWK=
D-423MG NHT0PVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTwVZhKSzVyPUO4MlQ5PjlizszN MkfQV2FPT0WU
NCI-H510A MkXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDZbHFKSzVyPUO4MlY1PTFizszN MkjsV2FPT0WU
NMC-G1 NFPNZ3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfwTWM2OD1|OD63NlIzKM7:TR?= NEKycW9USU6JRWK=
SW948 M4LheWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\PPHhKSzVyPUO4Mlg6PDlizszN NWL4WYFMW0GQR1XS
MFM-223 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfmUXlKSzVyPUO4Mlk1OzFizszN NXHud3p1W0GQR1XS
PAN1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TnPWlEPTB;M{iuPVkyQSEQvF2= MlrOV2FPT0WU
MZ7-mel NXvzdYt[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TDWWlEPTB;M{muNVE6QSEQvF2= NH\iV|VUSU6JRWK=
COLO-679 NHrY[WRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HZU2lEPTB;M{muPVcxQCEQvF2= NFHoPGhUSU6JRWK=
SW872 M{XVW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzwN5VlUUN3ME20NE4zODNzIN88US=> MkS4V2FPT0WU
HT-1197 MnrYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTRyLkK4Olkh|ryP M1;tOnNCVkeHUh?=
ES6 NEDDTpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTRyLkS1OVIh|ryP NIDGSYxUSU6JRWK=
SNU-387 NHTEV3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XkSWlEPTB;NECuPFI{QCEQvF2= NHG4RVBUSU6JRWK=
T47D MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\3d25KSzVyPUSxMlAyQTJizszN M3zEXHNCVkeHUh?=
G-402 M{fCSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILLcIJKSzVyPUSxMlA5ODlizszN NEjqZ5RUSU6JRWK=
MZ1-PC NYjFfGh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGP2VXBKSzVyPUSxMlgyKM7:TR?= NYmxfGFVW0GQR1XS
SW1417 Mmf6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjOdHhnUUN3ME20Nk4{ODNizszN MXLTRW5ITVJ?
RERF-LC-MS MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnH[5BXUUN3ME20Nk42ODh5IN88US=> NFO4WnRUSU6JRWK=
SF539 NUTS[GtRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\6TWM2OD12Mj61OVI6KM7:TR?= MlH2V2FPT0WU
ESS-1 MnTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnT3TWM2OD12Mz61OVU5KM7:TR?= NGrqSohUSU6JRWK=
RO82-W-1 NXHtW2R3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWf0dWI4UUN3ME20N{43OTV|IN88US=> MnTvV2FPT0WU
S-117 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIK0XFBKSzVyPUSzMlY6PThizszN MWnTRW5ITVJ?
SW756 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDKZ|FKSzVyPUSzMlgzPDJizszN M3O4[3NCVkeHUh?=
CP66-MEL M4njfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGf0VopKSzVyPUS1MlcyPDNizszN MmPzV2FPT0WU
H-EMC-SS MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\xO2ZKSzVyPUS1Mlc3QTNizszN NYDWXGxMW0GQR1XS
NCI-H2052 NViyPHBLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjIXXBCUUN3ME20OU46ODJ5IN88US=> NYHid4lLW0GQR1XS
SW684 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlS0TWM2OD12Nz6wNFgyKM7:TR?= NYPISJU4W0GQR1XS
HCC1569 NYjBfZd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\4fWlEPTB;NEeuNVY2QCEQvF2= M{LtXnNCVkeHUh?=
KGN NU\odXJsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\CZmRKSzVyPUS3MlM{OTFizszN NV[5W2lIW0GQR1XS
LCLC-103H MlzWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfMTZdzUUN3ME20O{41PDB2IN88US=> NVPqTHFGW0GQR1XS
SW780 M3W2bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHKTWM2OD12Nz62N|UyKM7:TR?= Ml3VV2FPT0WU
NCI-H1703 NV7VPZZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTR6LkOzOVIh|ryP MnrjV2FPT0WU
HCC1395 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\wVXJvUUN3ME20PE44PDN{IN88US=> MnXXV2FPT0WU

... Click to View More Cell Line Experimental Data

体内研究 Gefitinib 作用于无胸腺裸鼠,抑制SKOV3 或MDA-MB-231 肿瘤生长。Gefitinib高效作用于两种类型肿瘤。处理14天后,MDA-MB-231肿瘤和SKOV3肿瘤生长抑制分别为71%和32%。

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:[1]
+ 展开
  • Cell lines: NR6, NR6M 和 NR6W 细胞
  • Concentrations: 0 μM -2 μM
  • Incubation Time: 72 小时
  • Method: 呈指数生长的细胞,包括 NR6, NR6M, NR6M和NR6W细胞按6倍接种在96孔板上,每孔为2000个细胞, 粘附,随后在PBS 中清洗,然后在含0.5% FCS的培养基上温育过夜。使用不同浓度(0-2 μM) Gefitinib或溶质对照DMSO 和EGF 处理细胞。诱导NR6wtEGFR和NR6W 细胞增殖的EGF最佳浓度已经测定,因此NR6wtEGFR和 NR6W 细胞中分别加入10 nM和 0.1 nM EGF。NR6 和NR6M细胞中不加入EGF。72 小时后,通过MTT 增殖检测测量细胞数。
    (Only for Reference)
动物实验:[3]
+ 展开
  • Animal Models: 携带 SKOV3或MDA-MB-231肿瘤的无胸腺裸鼠
  • Formulation: 0.2% DMSO
  • Dosages: 75 mg/kg
  • Administration: 饲喂处理
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 89 mg/mL (199.14 mM)
Ethanol 4 mg/mL (8.95 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
1% CMC Na
30mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 446.90
化学式

C22H24ClFN4O3

CAS号 184475-35-2
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00025675 Completed Brain and Central Nervous System Tumors Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins|National Cancer Institute (NCI) October 9 2001 Phase 2
NCT03050164 Completed Bioequivalence Study Hunan Kelun Pharmaceutical Co. Ltd. September 8 2016 Phase 1
NCT00684385 Completed Non Small Cell Lung Cancer|Cancer of the Head and Neck AstraZeneca August 8 2001 Phase 4
NCT01933347 Active not recruiting Non Small Cell Lung Cancer Guangdong Association of Clinical Trials April 7 2014 Phase 2
NCT02411448 Active not recruiting Metastatic Non-Small Cell Lung Cancer Eli Lilly and Company May 6 2015 Phase 3
NCT03486496 Not yet recruiting Lung Adenocarcinoma|EGFR Mutation Fujian Cancer Hospital June 5 2018 Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    I try to dissolve Gefitinib (ZD1839) in 0.5% methylcellulose+0.2% Tween 80 for in vivo experiments. However, when I prepare the mixture, it forms precipitates. Exists another way to dissolve completely the compound?

  • 回答:

    S1025 can be dissovled in both 5% DMSO+corn oil and 5% DMSO+30% PEG 300+5% Tween 80+ddH2O at 2.5 mg/ml clearly. It dissolves in DMSO not readily, please sonicate and warm it in water bath at about 45 degree, and dissolve it clearly first. Then add other solvent.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID