Erlotinib (OSI-774)

For research use only. Not for use in humans.

目录号:S7786 别名: CP358774, NSC 718781, Tarceva 中文名称:厄洛替尼

Erlotinib (OSI-774) Chemical Structure

CAS No. 183321-74-6

Erlotinib (OSI-774, CP358774, NSC 718781, Tarceva)是一种EGFR抑制剂,IC50 为 2 nM,对EGFR的敏感性比对人c-Src 或 v-Ab高1000多倍。Erlotinib可诱导自噬。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 794.43 现货
RMB 812.23 现货
RMB 1603.19 现货
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客户使用Selleck生产的Erlotinib (OSI-774)发表文献472篇:

产品安全说明书

EGFR抑制剂选择性比较

生物活性

产品描述 Erlotinib (OSI-774, CP358774, NSC 718781, Tarceva)是一种EGFR抑制剂,IC50 为 2 nM,对EGFR的敏感性比对人c-Src 或 v-Ab高1000多倍。Erlotinib可诱导自噬。
靶点
EGFR [1]
(Cell-free assay)
2 nM
体外研究

Erlotinib HCl有效抑制完整细胞,包括HNS人头颈部肿瘤细胞(IC50 20nM),DiFi人结肠癌细胞和MDA MB-468人乳腺癌细胞中EGFR活化。Erlotinib HCl (1 μM)在DiFi人结肠癌细胞中诱导细胞凋亡。[1] Erlotinib抑制一组NSCLC细胞系,包括A549,H322,H3255,H358,H661,H1650,H1975,H1299,H596的生长,IC50范围为29 nM到>20 μM。[2] Erlotinib HCl(2 μM)显著抑制AsPC-1和BxPC-3胰细胞生长。[3] Erlotinib HCl与gemcitabine结合使用,在KRAS突变的胰腺癌细胞中具有协同作用。10微摩尔Erlotinib HCl抑制Y845 (Src依赖性磷酸化)和Y1068 (自身磷酸化)位点的EGFR磷酸化。[4]结合Erlotinib HCl能够下调rapamycin刺激的Akt活性,并产生协同的细胞生长抑制作用。[5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human SKBR3 cells M2jjemZ2dmO2aX;uJIF{e2G7 MXrJcohq[mm2aX;uJI9nKEiHUkKgbY4hcHWvYX6gV2tDWjNiY3XscJMh[nliSGTSSkBie3OjeTygTWM2OD1zLki5JO69VS5? NWHaTVBDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm4NVU1OTJpPkG5PFE2PDF{PD;hQi=>
human A431 cells Mn7KSpVv[3Srb36gZZN{[Xl? Mm\ETY5pcWKrdHnvckBw\iCHR1\SJIlvKGi3bXHuJGE1OzFiY3XscJMh[nliSGTSSkBie3OjeTygTWM2OD1yLkSyJO69VS5? MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQThzNUSxNkc,OTl6MUW0NVI9N2F-
Huh7.5 M{nKTGFvfGm4aYLhcEBie3OjeR?= NW\4eoJyOzBibXnudy=> MXvBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZBifGm2aYOgR{B3cXK3czDKOk9LTkhiaX7m[YN1\WRiaX6gbJVu[W5iSIXoO{42KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gTGNXKHKncHzpZ4F1cW:wIIDy[ZRz\WG2ZXSg[o9zKDNyIH3pcpMh\m:ubH;3[YQh[nliaX7m[YN1cW:wIH3lZZN2emWmIHHmeIVzKDd{IHjyd{BjgSCjbHHtZZIh[my3ZTDkfYUh[mG|ZXSg[ox2d3Knc3PlcoNmKGG|c3H5 NXjyUYEzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[5NlUzODhpPkK2PVI2OjB6PD;hQi=>
Huh7.5 MnHaRY51cX[rcnHsJIF{e2G7 M{f4NFczKGi{cx?= Mom4RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVx[XSrdHnzJGMhfmm{dYOgTlYwUk[KIHnu[oVkfGWmIHnuJIh2dWGwIFj1bFcvPSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqemGuIILldIxq[2G2aX;uJI1m[XO3cnXkJIFnfGW{IEeyJIhzeyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUCgQUAxNjVizszNMi=> Moj4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6MkK3N|koRjJ3OEKyO|M6RC:jPh?=
Huh7.5 MWXBcpRqfmm{YXygZZN{[Xl? NYXYbXZHPzJiaILz MYLBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZBifGm2aYOgR{B3cXK3czDKOk9LTkhiZXzlZ5Rzd3CxcnH0[YQhcW5iaIXtZY4hUHWqNz61JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiaX70doFk\WyudXzhdkBqdm[nY4Tpeol1gSCmcoXnJJRz\WG2ZXSg[ZZmenliMkSgbJJ{KG[xcjC3NkBpenNibXXhd5Vz\WRiN{KgbJJ{KHCxc4Sg[Yxm[3S{b4DvdoF1cW:wIHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NEA:KDBwNTFOwG0v NHTnNZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUiyNlc{QSd-MkW4NlI4Ozl:L3G+
Huh7.5 M{PIVGFvfGm4aYLhcEBie3OjeR?= NULLPJhsPzJiaILz NInzfmpCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XCjdHn0bZMhSyC4aYL1d{BLPi:MRligbY5n\WO2ZXSgbY4hcHWvYX6gTJVpPy53IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh\Xi2cnHj[YxtfWyjcjDpcoZm[3Srdnn0fUBlenWpIITy[YF1\WRiZY\ldpkhOjRiaILzJIZweiB5MjDodpMhdWWjc4Xy[YQh[W[2ZYKgO|IhcHK|IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NEA:KDBwNTFOwG0v NWm0UYpQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4NlI4OzlpPkK1PFIzPzN7PD;hQi=>
NCI-H292 MkHYRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MVi3NkBpenN? MV;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE6FST3INlkzKGOnbHzzJIV5eHKnc4Ppcochf2muZDD0fZBmKEWJRmKgZYZ1\XJiN{KgbJJ{KGK7IHz1cYlv\XOlZX7j[UBie3OjeTygSWM2OCB;IECuNFMyKM7:TT6= NYTVbnU{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0OVU6OTlpPkK2OFU2QTF7PD;hQi=>
A431 MWLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4K4T|czKGi{cx?= NILSXldIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBCPDNzIHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGVITlJiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiR1m1NEA:KDBwNEeg{txONg>? MmjVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd7OEO3OFUoRjF5OUizO|Q2RC:jPh?=
A431 NV;1OYR7T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnrVO|IhcHK| MV3Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDBOFMyKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGdKPTBiPTCwMlkyPSEQvF2u MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl4OUS2OUc,OTl7Nkm0OlU9N2F-
BA/F3 NGDadGJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWnZT4IzQTZiaILz MXrHdo94fGhiaX7obYJqfGmxbjDv[kBud3W|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKEWJRmKgSIVtOSCvdYThcpQh[W[2ZYKgPVYhcHK|IHL5JINmdGxidHn0[ZIu\2yxIHHzd4F6NCCJSUWwJF0hOC53IN88UU4> M3;HNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMkKyO|M{Lz5{MEKyNlc{OzxxYU6=
BA/F3 NVnUNINqT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVG4PHZ2QTZiaILz MULHdo94fGhiaX7obYJqfGmxbjDv[kBud3W|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKEWJRmKgSIVtOyCvdYThcpQh[W[2ZYKgPVYhcHK|IHL5JINmdGxidHn0[ZIu\2yxIHHzd4F6NCCJSUWwJF0hOC53IN88UU4> NXLNPXd2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCyNlI4OzNpPkKwNlIzPzN|PD;hQi=>
BA/F3 M4POe2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWG5OkBpenN? NUfRd5JzT3Kxd4ToJIlvcGmkaYTpc44hd2ZibX;1d4UhSkFxRkOgZ4VtdHNiZYjwdoV{e2mwZzDFS2ZTKESnbEWgcZV1[W62IHHmeIVzKDl4IHjyd{BjgSClZXzsJJRqfGW{LXfsc{Bie3OjeTygS2k2OCB;IECuOUDPxE1w NIK1c3U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEKyNlc{Oyd-MkCyNlI4OzN:L3G+
BA/F3 NFK3XHpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYm5OkBpenN? NILj[4lIem:5dHigbY5pcWKrdHnvckBw\iCvb4Xz[UBDSS:IMzDj[YxteyCneIDy[ZN{cW6pIFXHSnIhVDh3OGKgcZV1[W62IHHmeIVzKDl4IHjyd{BjgSClZXzsJJRqfGW{LXfsc{Bie3OjeTygS2k2OCB;IECuOUDPxE1w NFXwfVc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEKyNlc{Oyd-MkCyNlI4OzN:L3G+
WM266.4 MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIPUZpgzPCCqcoO= NHT1eJdIem:5dHigbY5pcWKrdHnvckBqdiCqdX3hckBYVTJ4Nj60JINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCPVGSgdoVlfWO2aX;uJIF{e2G7LDDHTVUxKD1iOD6xNkDPxE1w NX:ySHRtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK5PFU6PjJpPkKyPVg2QTZ{PD;hQi=>
A549 M{XLW2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 NHzNXXQzPCCqcoO= MUPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KE2WVDDhd5NigSxiR1m1NEA:KDBwMEOg{txONg>? MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzN7MUO2OEc,OjN|OUGzOlQ9N2F-
MCF7 MnfyRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M1z4[FI1KGi{cx?= NFHuW2tCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IF3UWEBie3OjeTygS2k2OCB;IECuNFgh|ryPLh?= NIexN5g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{O5NVM3PCd-MkOzPVE{PjR:L3G+
WM266.4 NXvBclZNSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NX7wUVNxOjRiaILz MXPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFePMk[2MlQh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiMkSgbJJ{KGK7IF3UWEBie3OjeTygS2k2OCB;IEiuNVQh|ryPLh?= NULuR4xIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkeyN|g5PDFpPkK3NlM5QDRzPD;hQi=>
NIH3T3 NWfKbYF{TnWwY4Tpc44h[XO|YYm= M1LPOWlvcGmkaYTpc44hd2ZiRVfGJJN1cW23bHH0[YQhcHWvYX6g[ZJjSjFiYYX0c5Bpd3OyaH;yfYxifGmxbjDpckBPUUh|VEOgZ4VtdHNuIFnDOVAhRSByLkCxPVMh|ryPLh?= MoLUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ2OECyPFQoRjF4NEiwNlg1RC:jPh?=
T24 NIH M2HUR2Z2dmO2aX;uJIF{e2G7 Mn25TY5pcWKrdHnvckBw\iCuaXfhcoQhe3SrbYXsZZRm\CCncnLCNkBifXSxcHjvd5Bpd3K7bHH0bY9vKGmwIGSyOEBPUUhiY3XscJMtKEmFNUCgQUAxNjJ7OTFOwG0v M2T5PFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NEiwNlg1Lz5zNkS4NFI5PDxxYU6=
Jurkat MnfFS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mn22NlQhcHK| MX7Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDKeZJs[XRiY3XscJMh[W[2ZYKgNlQhcHK|LDDJR|UxKD1iMjFOwG0v NITlcFk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G3PFczOid-MUexO|g4OjJ:L3G+
erythroleukemia cells NH25bWFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NU\2VIhLOjRiaILz NX7jfWFQT3Kxd4ToJIlvcGmkaYTpc44hd2ZiSlHLNkBXPjF5RjDteZRidnRiZYjwdoV{e2mwZzDoeY1idiCncon0bJJwdGW3a3XtbYEh[2WubIOgZYZ1\XJiMkSgbJJ{NCCLQ{WwJF0hOiEQvF2u MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF5OEeyNkc,OTdzN{i3NlI9N2F-
erythroleukemia cells NGfIPJJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYCyOEBpenN? MWPHdo94fGhiaX7obYJqfGmxbjDv[kBud3W|ZTDldpl1cHKxbHX1b4VucWFiY3XscJMh[W[2ZYKgNlQhcHK|LDDJR|UxKD1iMjFOwG0v NWTlUJVMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexO|g4OjJpPkG3NVc5PzJ{PD;hQi=>
COS7 M2j5SmZ2dmO2aX;uJIF{e2G7 MoXITY5pcWKrdHnvckBw\iCqdX3hckBLSUt{IG[2NVdHKG23dHHueEBmgHC{ZYPz[YQhcW5iQ1;TO{Bk\WyuczygTWM2OCB;IESg{txONg>? MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF5OEeyNkc,OTdzN{i3NlI9N2F-
hematopoietic progenitor cells MmjwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWrHdo94fGhiaX7obYJqfGmxbjDv[kBLSUt{IG[2NVdHKG23dHHueEBmgHC{ZYPzbY5oKGinbXH0c5BwcWW2aXOgdJJw\2WwaYTvdkBk\WyuczDpd49t[XSnZDDmdo9uKHCxbInjfZRp\W2rYTD2[ZJiKHCjdHnlcpQh[nliY3;sc456KG[xcn3pcoch[XO|YYmsJGlEPTBiPTC1JO69VS5? NXHaeW5RRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexO|g4OjJpPkG3NVc5PzJ{PD;hQi=>
BA/F3 MmnrR5l1d3SxeHnjbZR6KGG|c3H5 NX7UeGNbS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhSkFxRkOgZ4VtdHNiZYjwdoV{e2mwZzDFS2ZTKEx6NUjSJI12fGGwdDygTWM2OCB;IECuNFEzPSEQvF2u NW\jNnhrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyN|kzOjlpPkG5NlM6OjJ7PD;hQi=>
A431 NV[yN3luS3m2b4TvfIlkcXS7IHHzd4F6 M2nv[FczKGi{cx?= M1m1[mN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE1OzFiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFAvODl4IN88UU4> M2fvSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OEi4O|YyLz5zOUi4PFc3OTxxYU6=
MCF7 NHv4Z2JCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M1vPSFQ5KGi{cx?= MXLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwMEKg{txONg>? MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTlzNEizOUc,OTl7MUS4N|U9N2F-
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HepG2 NIjGdFJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= Mn3EOFghcHK| MXnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEincFeyJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkGyJO69VS5? MlXYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkK2OlAoRjJ|OU[yOlYxRC:jPh?=
A549 NUexVY0{SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NIjxU|c1QCCqcoO= NILoUlBCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuNVMh|ryPLh?= M{P1c|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OU[yOlYxLz5{M{m2NlY3ODxxYU6=
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HepG2 NXrjVZM5S3m2b4TvfIlkcXS7IHHzd4F6 NWjnSGVLPDhiaILz MVTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5zMjFOwG0v MmLEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzNES4OVQoRjJ2MUS0PFU1RC:jPh?=
A549 MoS0R5l1d3SxeHnjbZR6KGG|c3H5 MoTGOFghcHK| NH;HO2JEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkGzJO69VS5? NWPSPIoyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSxOFQ5PTRpPkK0NVQ1QDV2PD;hQi=>
A431 NGnMZ4RCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MnHJO|IhcHK| NGLZc4lCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG0N|Eh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IGPSRkBie3OjeTygTWM2OCB;IECuOFA6KM7:TT6= MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDF6M{e0Nkc,OjRzOEO3OFI9N2F-
NCI-H1975 NY\FUVB{SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NF2ybIs4OiCqcoO= MlnHRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCQQ1mtTFE6PzViY3XscJMh\XiycnXzd4lv\yCHR1\SJHQ4QTCPIH31eIFvfCCjZoTldkA4OiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwJF0hPi57IN88UU4> MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDF6M{e0Nkc,OjRzOEO3OFI9N2F-
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A431 M2nLN2N6fG:2b4jpZ4l1gSCjc4PhfS=> MVO3NkBpenN? MXTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOFMyKGOnbHzzJIV5eHKnc4PpcochTUeIUjDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMD63OUDPxE1w MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDRzMUGyN{c,OjR2MUGxNlM9N2F-
Calu3 M2Ltd2N6fG:2b4jpZ4l1gSCjc4PhfS=> NYXWT5lPPzJiaILz MnrJR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR4FtfTNiY3XscJMh\XiycnXzd4lv\yCKRWKyJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlk{KM7:TT6= M17MT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEGxNVI{Lz5{NESxNVEzOzxxYU6=
NCI-H1975 MYjDfZRwfG:6aXPpeJkh[XO|YYm= M{LreVczKGi{cx?= M3WwdmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5EUS2KMUm3OUBk\WyuczDlfJBz\XO|aX7nJGVITlJiTEi1PHIwXDd7MF2gcZV1[W62IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB3LkWxJO69VS5? MknvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR2MUGxNlMoRjJ2NEGxNVI{RC:jPh?=
A431 MXXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MlLEO|IhcHK| MVrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF2M{GgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IGPSRkBie3OjeTygTWM2OCB;IECuOVYh|ryPLh?= NXHmUYZqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1OlU6PjlpPkK0OVY2QTZ7PD;hQi=>
NCI-H1975 Ml\oRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NXW2cGJPPzJiaILz NFi2T5FCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIdm\mm2aX7pZk1z\XOrc4ThcpQhcHWvYX6gUmNKNUhzOUe1JINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTC3MlA3KM7:TT6= MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV4NUm2PUc,OjR3NkW5Olk9N2F-
Sf9 NVfMb4JRTnWwY4Tpc44h[XO|YYm= NHmxUG8yKGi{ NGfkNoZKdmirYnn0bY9vKG:oIHH1eI9xcG:|cHjvdplt[XSrb36gc4YhemWlb33ibY5idnRiRVfGVkBkgXSxcHzhd41q[yCmb33hbY4hMDZ2NTD0c{AyOTh4KTCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBU\jliY3XscJMh[W[2ZYKgNUBpeiCkeTDESWxHUUFxdHnt[U1z\XOxbI\l[EBndHWxcn;t[ZRzcWNiYX7hcJl{cXNuIFnDOVAhRSByLkCzNkDPxE1w M3HaRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkC3PVk5Lz5{NE[wO|k6QDxxYU6=
HepG2 MVjBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MoHoOFghcHK| NIDlN5RCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlEzKM7:TT6= M2Wze|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkC3PVk5Lz5{NE[wO|k6QDxxYU6=
A549 NIj4eW9CdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MmPsOFghcHK| NVPtXVRrSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlE{KM7:TT6= NVfD[JdpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2NFc6QThpPkK0OlA4QTl6PD;hQi=>
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HepG2 M{ezd2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 NFnBfnU1QCCqcoO= NHjWb2VCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlEzKM7:TT6= M4TGSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkOwOFEzLz5{NE[zNFQyOjxxYU6=
A549 NEmzWWpCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M{D2b|Q5KGi{cx?= NF6zTItCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuNVMh|ryPLh?= Mn[1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4M{C0NVIoRjJ2NkOwOFEzRC:jPh?=
Sf9 Mn2zSpVv[3Srb36gZZN{[Xl? MUixJIhz MX7Jcohq[mm2aX;uJI9nKGG3dH;wbI9{eGixconsZZRqd25ib3[gbJVu[W5iSFXSNkBkgXSxcHzhd41q[yCmb33hbY4hMGGvaX7vJIFkcWS|IE[3OkB1dyBzMkS1LUApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCVZkmgZ4VtdHNiYX\0[ZIhOSCqcjDifUB1cW2nLYLld49tfmWmIH\seY9zd22ndIL5MEBKSzVyIE2gNE4yPiEQvF2u M3:ycFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkOwOFEzLz5{NE[zNFQyOjxxYU6=
A431 M4\3TmZ2dmO2aX;uJIF{e2G7 MlTiTY5pcWKrdHnvckBw\iCHR1\SJIlvKGi3bXHuJGE1OzFiY3XscJMh[nlicHjvd5Bpd3S7cn;zbY5mKEWOSWPBJIF{e2G7LDDJR|UxKD1iMD6wNFEzKM7:TT6= MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDh7ME[1Nkc,OjR6OUC2OVI9N2F-
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