Erlotinib HCl (OSI-744)

For research use only. Not for use in humans.

目录号:S1023 别名: CP358774, NSC 718781 中文名称:盐酸厄洛替尼

Erlotinib HCl (OSI-744) Chemical Structure

CAS No. 183319-69-9

Erlotinib HCl (OSI-744, CP358774, NSC 718781)是一种EGFR抑制剂,在无细胞试验中IC50为2 nM,对EGFR的选择性比对人c-Src或v-Abl高1000多倍。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1564.29 现货
RMB 1183.19 现货
RMB 2211.3 现货
RMB 3012.92 现货
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客户使用Selleck生产的Erlotinib HCl (OSI-744)发表文献479篇:

产品安全说明书

EGFR抑制剂选择性比较

生物活性

产品描述 Erlotinib HCl (OSI-744, CP358774, NSC 718781)是一种EGFR抑制剂,在无细胞试验中IC50为2 nM,对EGFR的选择性比对人c-Src或v-Abl高1000多倍。
靶点
HER1/EGFR [1]
(Cell-free assay)
2 nM
体外研究

Erlotinib作用于HNS人头部和颈部肿瘤细胞,有效抑制EGFR自磷酸化,HNS人头部和颈部肿瘤细胞是表达高水平EGFR的细胞系。[1] Erlotinib对SBC-5细胞增殖没有作用效果。相反, Erlotinib 显著抑制PC-9细胞增殖,这种作用存在剂量依赖性,PC-9细胞在EGFR基因第19外显子含缺失突变。Erlotinib处理也不会影响SBC-5细胞迁移。[2] Erlotinib 抑制HPAC细胞和Capan-1细胞生长, IC50 分别为1.1和3µM。10 uM Erlotinib 抑制EGFR在 Y845 (Src依赖性磷酸化) 和和Y1068(自磷酸化)位点磷酸化。[3] Erlotinib 只有作用于最敏感的细胞株时,抑制细胞外信号调节激酶, Akt, 和S6。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human SKBR3 cells NF7VTFFHfW6ldHnvckBie3OjeR?= MX\Jcohq[mm2aX;uJI9nKEiHUkKgbY4hcHWvYX6gV2tDWjNiY3XscJMh[nliSGTSSkBie3OjeTygTWM2OD1zLki5JO69VS5? M4rkSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OEG1OFEzLz5zOUixOVQyOjxxYU6=
human A431 cells NEm1dm5HfW6ldHnvckBie3OjeR?= M1PLXmlvcGmkaYTpc44hd2ZiRVfGVkBqdiCqdX3hckBCPDNzIHPlcIx{KGK7IFjUVmYh[XO|YYmsJGlEPTB;MD60NkDPxE1w NI\nPGI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUixOVQyOid-MUm4NVU1OTJ:L3G+
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HepG2 M1vZV2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 MVu0PEBpenN? NH;SfHJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC1Mlgh|ryPLh?= NXK1NHB6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[4PVY4ODhpPkK2PFk3PzB6PD;hQi=>
NCI-H358 MoPMRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NHfGOJVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF7DTU1JOzV6IHPlcIx{KGGodHXyJIhzeyCkeTDBWHAh[2:wdHXueEBie3OjeTygTWM2OCB;IE[g{txONg>? MmG5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzNEO3O|goRjJyMUSzO|c5RC:jPh?=
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LNCAP M{\l[2N6fG:2b4jpZ4l1gSCjc4PhfS=> M376VlQh\GG7cx?= MmrmR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUG5ESVBiY3XscJMh[W[2ZYKgOEBl[Xm|IHL5JJBzd3CrZHn1cUBqd2SrZHWgd5RicW6rbnetZoF{\WRiZnz1c5JwdWW2cnnjJIFv[Wy7c3nzMEBKSzVyIE2gOk43OyEQvF2u NVS4UoZqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxOlk3ODFpPkKyNVY6PjBzPD;hQi=>
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NCI-H358 MnPIRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M4fudGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWg{PThiY3XscJMh[XO|ZYPz[YQh[XNidnnhZoxmKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDDR2s5KGG|c3H5MEBKSzVyIE2gOk45PSEQvF2u MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjh5OUOxOEc,OjZ6N{mzNVQ9N2F-
NCI-H1975 NX2zSYx5SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MmjJO|IhcHK| NYLSfXhlSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOR2kuUDF7N{WgZ4VtdHNiZYjwdoV{e2mwZzDFS2ZTKFR5OUDNJI12fGGwdDDh[pRmeiB5MjDodpMh[nliU2LCJIF{e2G7LDDJR|UxKD1iNj65JO69VS5? MkDmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzOEO3OFIoRjJ2MUizO|QzRC:jPh?=
NCI-H1975 MofxRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NYLwUGZIPzJiaILz M3u1[2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4Sg[4VncXSrbnniMZJme2m|dHHueEBpfW2jbjDOR2kuUDF7N{WgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IGPSRkBie3OjeTygTWM2OCB;IEeuNFYh|ryPLh?= MkTUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3NkW5OlkoRjJ2NU[1PVY6RC:jPh?=
A549 MlLBR5l1d3SxeHnjbZR6KGG|c3H5 MVu0PEBpenN? NV\jfHg{S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPy5yOUmg{txONg>? NU\tWJl4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NFA5OzBpPkK0PVAxQDNyPD;hQi=>
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NCI-H1975 MUDDfZRwfG:6aXPpeJkh[XO|YYm= MYO0PEBpenN? M1fWNmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5EUS2KMUm3OUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNz60PVgh|ryPLh?= NFjBcYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmwNFg{OCd-MkS5NFA5OzB:L3G+
HCC827 NGPDZoJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MWPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFQ{iyO{Bk\WyuczDh[pRmeiCqcoOgZpkhSVSSIHPvcpRmdnRiYYPzZZktKEmFNUCgQUA4NjVizszNMi=> NG\kT2M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEG0N|c4QCd-MkCxOFM4Pzh:L3G+
A549 Mke3RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MoPpO|IhcHK| MkTLRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNUS5JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEBxem:uaX\ldoF1cW:wIIXu[IVzKG6xcn3vfIliKGOxbnTpeIlwdnNiYX\0[ZIhPzJiaILzJIJ6KFOUQjDhd5NigSxiSVO1NEA:KDdwNUmg{txONg>? NXnLZ3ltRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW0OlgxPDRpPkK1OFY5ODR2PD;hQi=>
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NCI-H1975 NWfvcYRNTnWwY4Tpc44h[XO|YYm= MV6yJIhzew>? M1jscWlvcGmkaYTpc44hd2ZiRVfGVkBNQDV6Uj;UPVcxVSCmb4XicIUhdXW2YX70JJBpd3OyaH;yfYxifGmxbjDpckBpfW2jbjDOR2kuUDF7N{WgZ4VtdHNiYX\0[ZIhOiCqcoOgZpkh\my3b4Lld4NmdmOnIHHzd4F6NCCLQ{WwJF0hPy54IN88UU4> MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl|MEm5OEc,OjN7M{C5PVQ9N2F-
PCI35 NIfPOlNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFP1PXo4OiCqcoO= MXnHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDQR2k{PSClZXzsd{Bi\nSncjC3NkBpenNiYomgR2NMNThiYYPzZZktKEmFNUCgQUA4NjdizszNMi=> MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV2N{[5NEc,OjZ3NEe2PVA9N2F-
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MOLT-16 M3:ybmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MluwTWM2OCB;IEGuPVI6OjVizszN NXvtemRLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV|Lze+V2FPT0WUPD;hQi=>
TE-6 NUPYN2JCT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVvWepNYUUN3MDC9JFIvPTZ5ODFOwG0> MnrRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU{Nyd-U1HOS2VTRC:jPh?=
697 NFHQT5JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MX3JR|UxKD1iMj62OVMxPSEQvF2= MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVMwLz6VQV7HSXI9N2F-
A253 MYHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnPuTWM2OCB;IEKuO|UyPiEQvF2= NF7OXpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTNxJ{7TRW5ITVJ:L3G+
OS-RC-2 MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3TzUGlEPTBiPTCyMlk1ODJ|IN88US=> Ml;nQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU{Nyd-U1HOS2VTRC:jPh?=
KS-1 NIPoOWpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mlu4TWM2OCB;IEKuPVQ2PDJizszN MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVMwLz6VQV7HSXI9N2F-
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HCE-T NX[1[pM5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYDJR|UxKD1iND6xNFE5QCEQvF2= NEf3O|c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTNxJ{7TRW5ITVJ:L3G+
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TE-15 M{TMUGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGjqVWpKSzVyIE2gOU41PzJ5IN88US=> MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVMwLz6VQV7HSXI9N2F-
NOS-1 Mlq3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2fjcmlEPTBiPTC1MlQ6Ozh4IN88US=> MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVMwLz6VQV7HSXI9N2F-
EW-16 NVHRVoN5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHX4UGNKSzVyIE2gOk4zPTN6NzFOwG0> MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVMwLz6VQV7HSXI9N2F-
LAMA-84 NG\CfmdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkHHTWM2OCB;IEeuNFA4PzJizszN NV[zOHN7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV|Lze+V2FPT0WUPD;hQi=>
TE-5 M1HKeWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1TvdGlEPTBiPTC3MlA1OjR5IN88US=> M1LZ[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2Oy9pPmPBUmdGWjxxYU6=
HEL NXXjXmN5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2i0b2lEPTBiPTC3MlM{PTZ2IN88US=> NVjRPZpRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV|Lze+V2FPT0WUPD;hQi=>
NCI-H209 NFv3flRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4eweWlEPTBiPTC4MlA1PDF{IN88US=> MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVMwLz6VQV7HSXI9N2F-
DJM-1 MV\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NV3ZTJhUUUN3MDC9JFgvPTJ7NkSg{txO M4jkOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2Oy9pPmPBUmdGWjxxYU6=
OVCAR-4 NHLxN3JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkDLTWM2OCB;IEiuPFQzOTlizszN NHv4T|A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTNxJ{7TRW5ITVJ:L3G+
NB17 NEXGWZVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3OycmlEPTBiPTC5MlI2QTlzIN88US=> MnXqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU{Nyd-U1HOS2VTRC:jPh?=
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NB5 NWHwVXlOT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NELHTGFKSzVyIE2gNVAvOjlizszN