Erlotinib HCl (OSI-744)

For research use only. Not for use in humans.

目录号:S1023 别名: CP358774, NSC 718781 中文名称:盐酸厄洛替尼

Erlotinib HCl (OSI-744) Chemical Structure

CAS No. 183319-69-9

Erlotinib HCl (OSI-744, CP358774, NSC 718781)是一种EGFR抑制剂,在无细胞试验中IC50为2 nM,对EGFR的选择性比对人c-Src或v-Abl高1000多倍。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1564.29 现货
RMB 1183.19 现货
RMB 2211.3 现货
RMB 3012.92 现货
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客户使用Selleck生产的Erlotinib HCl (OSI-744)发表文献462篇:

产品安全说明书

EGFR抑制剂选择性比较

生物活性

产品描述 Erlotinib HCl (OSI-744, CP358774, NSC 718781)是一种EGFR抑制剂,在无细胞试验中IC50为2 nM,对EGFR的选择性比对人c-Src或v-Abl高1000多倍。
靶点
HER1/EGFR [1]
(Cell-free assay)
2 nM
体外研究

Erlotinib作用于HNS人头部和颈部肿瘤细胞,有效抑制EGFR自磷酸化,HNS人头部和颈部肿瘤细胞是表达高水平EGFR的细胞系。[1] Erlotinib对SBC-5细胞增殖没有作用效果。相反, Erlotinib 显著抑制PC-9细胞增殖,这种作用存在剂量依赖性,PC-9细胞在EGFR基因第19外显子含缺失突变。Erlotinib处理也不会影响SBC-5细胞迁移。[2] Erlotinib 抑制HPAC细胞和Capan-1细胞生长, IC50 分别为1.1和3µM。10 uM Erlotinib 抑制EGFR在 Y845 (Src依赖性磷酸化) 和和Y1068(自磷酸化)位点磷酸化。[3] Erlotinib 只有作用于最敏感的细胞株时,抑制细胞外信号调节激酶, Akt, 和S6。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human SKBR3 cells NX:3[2l3TnWwY4Tpc44h[XO|YYm= MWjJcohq[mm2aX;uJI9nKEiHUkKgbY4hcHWvYX6gV2tDWjNiY3XscJMh[nliSGTSSkBie3OjeTygTWM2OD1zLki5JO69VS5? NVLjNYE6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm4NVU1OTJpPkG5PFE2PDF{PD;hQi=>
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NCI-H358 NFfJPJRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NVv6NW9mSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOR2kuUDN3ODDj[YxteyCjZoTldkBpenNiYomgRXRRKGOxboTlcpQh[XO|YYmsJGlEPTBiPTC2JO69VS5? NIrIO3U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEG0N|c4QCd-MkCxOFM4Pzh:L3G+
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NCI-H358 M3exdWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 Mn\FRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCQQ1mtTFM2QCClZXzsd{Bie3Onc4Pl[EBieyC4aXHicIUh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IFPDT|gh[XO|YYmsJGlEPTBiPTC2Mlg2KM7:TT6= NV7Wcpk5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[4O|k{OTRpPkK2PFc6OzF2PD;hQi=>
NCI-H1975 MlTORY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MV[3NkBpenN? NYjwWFl{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOR2kuUDF7N{WgZ4VtdHNiZYjwdoV{e2mwZzDFS2ZTKFR5OUDNJI12fGGwdDDh[pRmeiB5MjDodpMh[nliU2LCJIF{e2G7LDDJR|UxKD1iNj65JO69VS5? MkPzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzOEO3OFIoRjJ2MUizO|QzRC:jPh?=
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A549 MXrBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M4q3flQ5KGi{cx?= MnG0RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNUS5JINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgZ4NsQCCjc4PhfUwhUUN3MDC9JFcvOzVizszNMi=> NVvDO2FJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkeyN|Q5QDdpPkK3NlM1QDh5PD;hQi=>
NCI-H1975 NXexPXhXS3m2b4TvfIlkcXS7IHHzd4F6 MkTROFghcHK| NH\LTIlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBPS0lvSEG5O|Uh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEeuOFk5KM7:TT6= MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDlyMEizNEc,OjR7MEC4N|A9N2F-
HCC827 MWTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NHiwVI1CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDR|gzPyClZXzsd{Bi\nSncjDodpMh[nliQWTQJINwdnSnboSgZZN{[XluIFnDOVAhRSB5LkWg{txONg>? M3\rXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUSzO|c5Lz5{MEG0N|c4QDxxYU6=
A549 M17SW2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 M2j3UlczKGi{cx?= M{H6U2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHPlcIwheHKxbHnm[ZJifGmxbjD1coRmeiCwb4Ltc5hq[SClb37kbZRqd26|IHHmeIVzKDd{IHjyd{BjgSCVUlKgZZN{[XluIFnDOVAhRSB5LkW5JO69VS5? NVnSdFF5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW0OlgxPDRpPkK1OFY5ODR2PD;hQi=>
BxPC3 MUHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NFnvO5BCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFL4VGM{KGOnbHzzJIFnfGW{IHjyd{BjgSCDVGCgZ49vfGWwdDDhd5NigSxiSVO1NEA:KDdwNjFOwG0v NGfSUHI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEG0N|c4QCd-MkCxOFM4Pzh:L3G+
NCI-H1975 MV\GeY5kfGmxbjDhd5NigQ>? MX:yJIhzew>? MX\Jcohq[mm2aX;uJI9nKEWJRmKgUFg2QFJxVEm3NG0h\G:3YnzlJI12fGGwdDDwbI9{eGixconsZZRqd25iaX6gbJVu[W5iTlPJMWgyQTd3IHPlcIx{KGGodHXyJFIhcHK|IHL5JIZtfW:{ZYPj[Y5k\SCjc4PhfUwhUUN3MDC9JFcvPiEQvF2u M2Ti[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OUOwPVk1Lz5{M{mzNFk6PDxxYU6=
PCI35 NXrvcYZpT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWW3NkBpenN? Mkn2S5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gVGNKOzViY3XscJMh[W[2ZYKgO|IhcHK|IHL5JGNEUy16IHHzd4F6NCCLQ{WwJF0hPy55IN88UU4> NEjGNmc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW0O|Y6OCd-Mk[1OFc3QTB:L3G+
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