Erlotinib HCl (OSI-744)

For research use only. Not for use in humans.

目录号:S1023 别名: CP358774, NSC 718781 中文名称:盐酸厄洛替尼

Erlotinib HCl (OSI-744) Chemical Structure

CAS No. 183319-69-9

Erlotinib HCl (OSI-744, CP358774, NSC 718781)是一种EGFR抑制剂,在无细胞试验中IC50为2 nM,对EGFR的选择性比对人c-Src或v-Abl高1000多倍。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1564.29 现货
RMB 1183.19 现货
RMB 2211.3 现货
RMB 3012.92 现货
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客户使用Selleck生产的Erlotinib HCl (OSI-744)发表文献420篇:

产品安全说明书

EGFR抑制剂选择性比较

生物活性

产品描述 Erlotinib HCl (OSI-744, CP358774, NSC 718781)是一种EGFR抑制剂,在无细胞试验中IC50为2 nM,对EGFR的选择性比对人c-Src或v-Abl高1000多倍。
靶点
HER1/EGFR [1]
(Cell-free assay)
2 nM
体外研究

Erlotinib作用于HNS人头部和颈部肿瘤细胞,有效抑制EGFR自磷酸化,HNS人头部和颈部肿瘤细胞是表达高水平EGFR的细胞系。[1] Erlotinib对SBC-5细胞增殖没有作用效果。相反, Erlotinib 显著抑制PC-9细胞增殖,这种作用存在剂量依赖性,PC-9细胞在EGFR基因第19外显子含缺失突变。Erlotinib处理也不会影响SBC-5细胞迁移。[2] Erlotinib 抑制HPAC细胞和Capan-1细胞生长, IC50 分别为1.1和3µM。10 uM Erlotinib 抑制EGFR在 Y845 (Src依赖性磷酸化) 和和Y1068(自磷酸化)位点磷酸化。[3] Erlotinib 只有作用于最敏感的细胞株时,抑制细胞外信号调节激酶, Akt, 和S6。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human SKBR3 cells NEDPeZJHfW6ldHnvckBie3OjeR?= NFTLbmRKdmirYnn0bY9vKG:oIFjFVlIhcW5iaIXtZY4hW0uEUkOgZ4VtdHNiYomgTHRTTiCjc4PhfUwhUUN3ME2xMlg6KM7:TT6= NXjSdGtQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm4NVU1OTJpPkG5PFE2PDF{PD;hQi=>
human A431 cells NXXyTJBRTnWwY4Tpc44h[XO|YYm= NEDvPZRKdmirYnn0bY9vKG:oIFXHSnIhcW5iaIXtZY4hSTR|MTDj[YxteyCkeTDIWHJHKGG|c3H5MEBKSzVyPUCuOFIh|ryPLh?= MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQThzNUSxNkc,OTl6MUW0NVI9N2F-
A431 M2jxd2Z2dmO2aX;uJIF{e2G7 NYj4OmVKUW6qaXLpeIlwdiCxZjDFS2ZTKGmwIHj1cYFvKEF2M{GgZ4VtdHNiYomgdIhwe3Cqb4T5do9{cW6nIFXMTXNCKGG|c3H5MEBKSzVyIE2gNE4xODF{IN88UU4> NV3jXpd3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4PVA3PTJpPkK0PFkxPjV{PD;hQi=>
MCF7 NX;ie3lxS3m2b4TvfIlkcXS7IHHzd4F6 M3ez[2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGVTNXCxc3n0bZZmKE2FRkegZ4VtdHNuIFnDOVAhRSByLkCwNVIh|ryPLh?= NUG3SIF3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4PVA3PTJpPkK0PFkxPjV{PD;hQi=>
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A431 MkfpSpVv[3Srb36gZZN{[Xl? MkD1OlAhdWmwcx?= NVPzT25TUW6qaXLpeIlwdiCxZjDFS2ZTKGmwIHj1cYFvKEF2M{GgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCHR1[tbY5lfWOnZDD0fZJwe2mwZTDwbI9{eGixconsZZRqd25iaX7jeYJifGWmIH\vdkA3OCCvaX7zJJBzcW:{IITvJGVITi2jY4TpeoF1cW:wIH3lZZN2emWmIEGwJI1qdnNiYomgSWxKW0FuIFnDOVAhRSBzLkKg{txONg>? NV[xSpl5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0N|QyOzlpPkKzOFM1OTN7PD;hQi=>
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HT-29 NEK1PY9CdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NFP3N5E4OiCqcoO= M{\KbGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSGStNlkh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKHC{b3zp[oVz[XSrb36geY5l\XJibn;ycY95cWFiY3;u[Il1cW:wczDh[pRmeiB5MjDodpMh[nliU2LCJIF{e2G7LDDJR|UxKD1iMj65PEDPxE1w MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR4OEC0OEc,OjV2NkiwOFQ9N2F-
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NCI-H358 NULLOYMxSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NUjVfVNMPDhiaILz MVLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE6FST3IN|U5KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkh[2OtODDhd5NigSxiSVO1NEA:KDNwOUGg{txONg>? NGTEO4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{KzOFg5Pyd-MkeyN|Q5QDd:L3G+
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OVCAR3 NInp[VFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MlrtO|IhcHK| NYTnPJJySW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDPWmNCWjNiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JGNmdGyWaYTldk1IdG9iYYPzZZktKEmFNUCgQUA1NjZizszNMi=> MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV7OUWzNkc,OjZ3OUm1N|I9N2F-
Calu3 M136cGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MW[3NkBpenN? MWfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEOjbIWzJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XJiYnz1[UBie3OjeTygTWM2OCB;IESuO{DPxE1w Mon2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3OUm1N|IoRjJ4NUm5OVMzRC:jPh?=
hematopoietic progenitor cell Ml\sS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYTRNFhJT3Kxd4ToJIlvcGmkaYTpc44hd2ZiSlHLNkBXPjF5RjDteZRidnRiZYjwdoV{e2mwZzDo[Y1ifG:yb3nleIlkKHC{b3flcol1d3JiY3XscJMhcXOxbHH0[YQh\nKxbTDwc4x6[3m2aHXtbYEhfmW{YTDwZZRq\W62IHL5JINwdG:weTDmc5JucW6pIHHzd4F6NCCLQ{WwJF0hPSEQvF2u Mlv4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzN{i3NlIoRjF5MUe4O|IzRC:jPh?=
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NCI-H1975 NFnHNmFEgXSxdH;4bYNqfHliYYPzZZk> NFu2eFI4OiCqcoO= NHLQdItEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBPS0lvSEG5O|Uh[2WubIOg[ZhxemW|c3nu[{BGT0[UIFy4OVhTN1R5OUDNJI12fGGwdDDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNT61NUDPxE1w MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDRzMUGyN{c,OjR2MUGxNlM9N2F-
MRC5 MVzBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NFr5Rmw4OiCqcoO= NIXSfpVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3SR|Uh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8h[XO|YYmsJGlEPTBiPTC1Mlgh|ryPLh?= MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV7OUWzNkc,OjZ3OUm1N|I9N2F-
HepG2 M2XHS2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 MlvDOFghcHK| MnrKRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZYDHNkBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNT64JO69VS5? NGWzS3k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nki5OlcxQCd-Mk[4PVY4ODh:L3G+
NCI-H358 NXrENG43SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NVm3U2NSSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOR2kuUDN3ODDj[YxteyCjZoTldkBpenNiYomgRXRRKGOxboTlcpQh[XO|YYmsJGlEPTBiPTC2JO69VS5? NYHUVVM4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxOFM4PzhpPkKwNVQ{Pzd6PD;hQi=>
A549 NWPzfo1iSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MV\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiYYPz[ZN{\WRiYYOgeoli[mynIHPlcIx{KGGodHXyJFQ5KGi{czDifUBES0t6IHHzd4F6NCCLQ{WwJF0hPi5{NjFOwG0v NHnVdJQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nki3PVMyPCd-Mk[4O|k{OTR:L3G+
LNCAP M3ewO2N6fG:2b4jpZ4l1gSCjc4PhfS=> MnnTOEBl[Xm| M3\RTGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGxPS0GSIHPlcIx{KGGodHXyJFQh\GG7czDifUBxem:yaXTpeY0hcW:maXTlJJN1[WmwaX7nMYJie2WmIH\seY9zd22ndILpZ{BidmGueYPpd{whUUN3MDC9JFYvPjNizszNMi=> NVKxVIpIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxOlk3ODFpPkKyNVY6PjBzPD;hQi=>
MIAPaCa MmjpSpVv[3Srb36gZZN{[Xl? NYTzfGxjUW6qaXLpeIlwdiCxZjDFVmJjOiCyaH;zdIhwenmuYYTpc44hcW5iaIXtZY4hVUmDUHHDZUBk\WyuczDifUBGVEmVQTygTWM2OCB;IE[uO|Mh|ryPLh?= NFfNOI09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEixO|UzOyd-MkC4NVc2OjN:L3G+
NCI-H358 MWHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MlTYRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCQQ1mtTFM2QCClZXzsd{Bie3Onc4Pl[EBieyC4aXHicIUh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IFPDT|gh[XO|YYmsJGlEPTBiPTC2Mlg2KM7:TT6= MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjh5OUOxOEc,OjZ6N{mzNVQ9N2F-
NCI-H1975 NWrSd|FESW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NYL0PHlSPzJiaILz NHq1botCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF7DTU1JOTl5NTDj[YxteyCneIDy[ZN{cW6pIFXHSnIhXDd7MF2gcZV1[W62IHHmeIVzKDd{IHjyd{BjgSCVUlKgZZN{[XluIFnDOVAhRSB4Lkmg{txONg>? M1:0c|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUizO|QzLz5{NEG4N|c1OjxxYU6=
NCI-H1975 NWPhUYNKSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MkPKO|IhcHK| MXHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHfl[ol1cW6rYj3y[ZNqe3SjboSgbJVu[W5iTlPJMWgyQTd3IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCVUlKgZZN{[XluIFnDOVAhRSB5LkC2JO69VS5? NVjSPVkyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1OlU6PjlpPkK0OVY2QTZ7PD;hQi=>
A549 NX\BRmltS3m2b4TvfIlkcXS7IHHzd4F6 NYDKU2VTPDhiaILz Mo\DR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gO{4xQTlizszNMi=> MonzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7MEC4N|AoRjJ2OUCwPFMxRC:jPh?=
A549 M1jGd2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 MUK0PEBpenN? NE\QZndCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFQ5KGi{czDifUBk[2t6IHHzd4F6NCCLQ{WwJF0hPy5|NTFOwG0v NYPWO4tbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkeyN|Q5QDdpPkK3NlM1QDh5PD;hQi=>
NCI-H1975 NEPQRXNEgXSxdH;4bYNqfHliYYPzZZk> MYe0PEBpenN? NV:ycFNiS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVkOLLVixPVc2KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC3MlQ6QCEQvF2u MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDlyMEizNEc,OjR7MEC4N|A9N2F-
HCC827 NH\wSXRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M2ftTmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFPDPFI4KGOnbHzzJIFnfGW{IHjyd{BjgSCDVGCgZ49vfGWwdDDhd5NigSxiSVO1NEA:KDdwNTFOwG0v NEfwRlU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEG0N|c4QCd-MkCxOFM4Pzh:L3G+
A549 MkizRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NHrLcZY4OiCqcoO= M{DFNmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHPlcIwheHKxbHnm[ZJifGmxbjD1coRmeiCwb4Ltc5hq[SClb37kbZRqd26|IHHmeIVzKDd{IHjyd{BjgSCVUlKgZZN{[XluIFnDOVAhRSB5LkW5JO69VS5? NETSNlg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUS2PFA1PCd-MkW0OlgxPDR:L3G+
BxPC3 MUnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MmjtRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCEeGDDN{Bk\WyuczDh[pRmeiCqcoOgZpkhSVSSIHPvcpRmdnRiYYPzZZktKEmFNUCgQUA4NjZizszNMi=> MnrLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzNEO3O|goRjJyMUSzO|c5RC:jPh?=
NCI-H1975 Mof2SpVv[3Srb36gZZN{[Xl? M{L1SlIhcHK| M17wTmlvcGmkaYTpc44hd2ZiRVfGVkBNQDV6Uj;UPVcxVSCmb4XicIUhdXW2YX70JJBpd3OyaH;yfYxifGmxbjDpckBpfW2jbjDOR2kuUDF7N{WgZ4VtdHNiYX\0[ZIhOiCqcoOgZpkh\my3b4Lld4NmdmOnIHHzd4F6NCCLQ{WwJF0hPy54IN88UU4> MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl|MEm5OEc,OjN7M{C5PVQ9N2F-
PCI35 NX7odlJLT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Ml3jO|IhcHK| MoXmS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gVGNKOzViY3XscJMh[W[2ZYKgO|IhcHK|IHL5JGNEUy16IHHzd4F6NCCLQ{WwJF0hPy55IN88UU4> MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV2N{[5NEc,OjZ3NEe2PVA9N2F-
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ST486 NH70OFdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXzJR|UxKD1iMkCuOFA6OyEQvF2= NF\kXpY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTNxJ{7TRW5ITVJ:L3G+
LC-2-ad MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGL1UWpKSzVyIE2gNlAvQTZ|NzFOwG0> NUftUoNPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV|Lze+V2FPT0WUPD;hQi=>
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BE-13 Mli0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXfIXYRuUUN3MDC9JFIyNjhzNUig{txO MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVMwLz6VQV7HSXI9N2F-
no-11 NX\lVWdpT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYTlVo5LUUN3MDC9JFIyNjlzME[g{txO M4\3TVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2Oy9pPmPBUmdGWjxxYU6=
TE-8 MljOS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{HkfmlEPTBiPTCyNk43OzF6IN88US=> MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVMwLz6VQV7HSXI9N2F-
NB6 M2XBPGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnHSTWM2OCB;IEKyMlg{ODNizszN MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVMwLz6VQV7HSXI9N2F-
BB65-RCC MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{f0S2lEPTBiPTCyNk46PjJ|IN88US=> MkTXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU{Nyd-U1HOS2VTRC:jPh?=
SK-UT-1 NVLQT2xxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2XobWlEPTBiPTCyN{4yPDl5IN88US=> MonmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU{Nyd-U1HOS2VTRC:jPh?=
D-392MG MV\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2DsR2lEPTBiPTCyOE4zQTN2IN88US=> M4W2elxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2Oy9pPmPBUmdGWjxxYU6=
JVM-2 MnziS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkjSTWM2OCB;IEK0MlU{OzNizszN MmH5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU{Nyd-U1HOS2VTRC:jPh?=
SW954 MlfBS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2nzS2lEPTBiPTCyOE42QTF4IN88US=> M2nnTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2Oy9pPmPBUmdGWjxxYU6=
QIMR-WIL NGq1OYdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUG0S2I3UUN3MDC9JFI2NjF7N{Og{txO NV\GZndwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV|Lze+V2FPT0WUPD;hQi=>
MEG-01 NWLZeZl1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYrU[Ww1UUN3MDC9JFI2NjlyMU[g{txO NWDLOmRtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV|Lze+V2FPT0WUPD;hQi=>
A101D MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mn3uTWM2OCB;IEK4MlcyOzlizszN MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVMwLz6VQV7HSXI9N2F-
LB831-BLC MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{XGUWlEPTBiPTCzNE41ODB2IN88US=> M1W1R|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2Oy9pPmPBUmdGWjxxYU6=
KGN NH;LNVRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUHJR|UxKD1iM{CuPFY3OSEQvF2= NH7mOWg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTNxJ{7TRW5ITVJ:L3G+
HC-1 NGiwXmNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NV\ZO4x6UUN3MDC9JFMyNjN3MEig{txO MmX1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU{Nyd-U1HOS2VTRC:jPh?=
CP66-MEL MlrKS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXPGOHFpUUN3MDC9JFMyNjh|Nk[g{txO MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVMwLz6VQV7HSXI9N2F-
D-542MG NXXrUGpIT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEHhVXZKSzVyIE2gN|IvPDN|NzFOwG0> MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVMwLz6VQV7HSXI9N2F-
LS-513 MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M13MdGlEPTBiPTCzN{41QDR2IN88US=> NIfpemE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTNxJ{7TRW5ITVJ:L3G+
DOHH-2 MXPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4LjOWlEPTBiPTCzN{43PTh7IN88US=> NXz3OodvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV|Lze+V2FPT0WUPD;hQi=>
NB69 Ml3YS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MV;JR|UxKD1iM{OuPVIxPiEQvF2= MknuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU{Nyd-U1HOS2VTRC:jPh?=
SW962 NIHWVWFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWLZSHlvUUN3MDC9JFM2Njd{MUeg{txO NXn0W4QyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV|Lze+V2FPT0WUPD;hQi=>
J-RT3-T3-5 NVL0XINYT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXPJR|UxKD1iM{[uNFczPCEQvF2= MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVMwLz6VQV7HSXI9N2F-
MONO-MAC-6 MV7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NX\NeVhvUUN3MDC9JFM3NjV|NUmg{txO M{HKW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2Oy9pPmPBUmdGWjxxYU6=
MLMA MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4LCfGlEPTBiPTCzPE43PTJizszN MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVMwLz6VQV7HSXI9N2F-
HOP-62 NYXte5ptT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHexZZRKSzVyIE2gN|kvOTd4NTFOwG0> MkfQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU{Nyd-U1HOS2VTRC:jPh?=
LP-1 NIDpWHZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYDJR|UxKD1iM{muOFQyPSEQvF2= MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVMwLz6VQV7HSXI9N2F-
ONS-76 MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVTJR|UxKD1iM{muPVE2OiEQvF2= M2eyPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2Oy9pPmPBUmdGWjxxYU6=
KNS-42 MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1j2ZWlEPTBiPTC0NE4xPTNzIN88US=> NVqxemVxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV|Lze+V2FPT0WUPD;hQi=>
NCI-H1581 MluyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{HDb2lEPTBiPTC0NU4yQDR{IN88US=> MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVMwLz6VQV7HSXI9N2F-
DSH1 MoPYS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NX3lOI1NUUN3MDC9JFQzNjRyNzFOwG0> NXnXPYxNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV|Lze+V2FPT0WUPD;hQi=>
NCI-H1355 Ml7RS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVnIOmoxUUN3MDC9JFQzNjh|OTFOwG0> NEHGfGo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTNxJ{7TRW5ITVJ:L3G+
D-247MG MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkXkTWM2OCB;IES1MlcyQSEQvF2= MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVMwLz6VQV7HSXI9N2F-
MC-CAR M4Xu[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWe1[G1LUUN3MDC9JFQ2Njl4OUGg{txO MmLoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU{Nyd-U1HOS2VTRC:jPh?=
EW-1 M3TEOmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFfJOVBKSzVyIE2gOFcvPTZ{NDFOwG0> NXO5bZdwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV|Lze+V2FPT0WUPD;hQi=>
GI-ME-N NFfkfHFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXzJR|UxKD1iNEiuNVM5PCEQvF2= MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVMwLz6VQV7HSXI9N2F-
BT-474 MmfSS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MX7JR|UxKD1iNEiuNVc{QCEQvF2= MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVMwLz6VQV7HSXI9N2F-
LB373-MEL-D M2XCT2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWjJR|UxKD1iNEiuO|U3OyEQvF2= NXr1NZJKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV|Lze+V2FPT0WUPD;hQi=>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-Met / Met / p-Axl / Axl / pERK / ERK / pEGFR / EGFR / p-STAT3 / STAT3 / p-Akt / Akt; 

PubMed: 28604685     


(b) Patient derived primary GBM neurospheres (GBM9) were exposure to erlotinib (1µM) for the indicated times followed by Western blot with the indicated antibodies. (c–d) A similar experiment in patient derived GBM neurospheres from two different patients (GBM39 and SK987). (e) U87EGFR cells were treated with erlotinib (1µM) for the indicated times followed by Western blot with the indicated antibodies. (f) Similar experiment was conducted in U87EGFRvIII cells.

p-Raf-1 / Raf-1 / p-MEK / MEK; 

PubMed: 27508092     


Cells from both ER and ECR groups were treated with 3 μM erlotinib for 72 h. Cell lysates were used for Western blotting with indicated antibodies.

cleaved PARP / PARP; 

PubMed: 27508092     


HCC827 or H1650 cells were treated with DMSO, celecoxib, erlotinib alone, or in combination for 48 h. Western blot analysis showed that cleaved PARP was higher in cells after combination treatment.

p27 / pS10-p27 / pT157-p27 / pT187-p27; 

PubMed: 21045138     


BT-474 and SK-BR-3 cells were treated with erlotinib at 0, 1, or 3 µM for 72 h, after which expression of total p27, p27 phosphorylated at S10 (pS10-p27), pT157-p27, and pT187-p27 was assessed by western blot analysis. β-actin was used as a loading control. 

Bcl-2 / Bcl-xl / Mcl-1 / Bax / Bak / Bad / Bim EL / PUMA; 

PubMed: 17927446     


Effects of erlotinib treatment on proapoptotic and antiapoptotic proteins in H3255 cells. H3255 cells were treated with different concentrations of erlotinib for 24 h. Cell lysates were examined by immunoblotting using antibodies specific for the indicated proteins.

28604685 27508092 21045138 17927446
Immunofluorescence
Bax / Cyto C; 

PubMed: 17927446     


Erlotinib induces colocalization of BAX and cytochrome c in PC-9 cells undergoing apoptosis. Cells were grown in Lab-Tek II chambers and treated with 100 nM erlotinib or DMSO for 48 h, fixed and immunostained with antibodies against BAX (green) and cytochrome c (red) or with DAPI to detect DNA (blue). Cells were imaged by confocal microscopy.

E-cadherin / β-catenin / Vimentin; 

PubMed: 19825949     


SUM149 cells were plated in 3D culture without or with erlotinib for 4 days. Immunofluorescence analysis was performed to detect E-cadherin, β-catenin, and vimentin. Nuclei were visualized with DAPI.

EGFR ; 

PubMed: 27612423     


HCC827 (delE746-A750), NCI-H3255 (L858R) and NCI-H1975 (L858R/T790M) cells were treated either with DMSO (control) or with 3 μM erlotinib/200 nM AZD9291 for the indicated time points. Cells were fixed and stained with EGFR antibody (red) and DAPI (blue, DNA dye) as described in the Materials and Methods. Representative images showing decreased EGFR immunofluorescence in erlotinib-sensitive HCC827 and NCI-H3255 cells. AZD9291 also reduced EGFR immunofluorescence even in NCI-H1975 cells. Scale bars, 10 μm. 

17927446 19825949 27612423
Growth inhibition assay
Cell viability; 

PubMed: 30377412     


a The MTT assay for PANC-1 viability. Different doses of erlotinib were added to the medium of PANC-1 cells. b LDH release was used to evaluate the cell death in PANC-1 cells in the presence of erlotinib. c The MTT assay for PaCa-2 cells in the presence of erlotinib treatment. d LDH release was used to evaluate the cell death in PaCa-2 cells in the presence of erlotinib.

30377412
体内研究 Erlotinib单独作用于H460a肿瘤模型,抑制肿瘤生长,这种作用存在剂量依赖性,与药物的循环水平相关。

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[1]
- 合并

激酶实验:

每孔使用100 μL 溶于PBS的0.25 mg/mL PGT对96孔板包被,然后在37oC温育过夜。吸取移除过量PGT,使用冲洗 buffer (0.1% Tween-20,溶于PBS)清洗实验板3次。在 50 μL 50 mM HEPES (pH 7.3), 含125 mM NaCl, 24 mM MgCl2, 0.1 mM 原钒酸钠, 20 μM ATP, 1.6 μg/mL EGF, 以及从A431细胞膜上亲和纯化的15 ng EGFR的混合物中进行激酶反应。加入溶于 DMSO的 Erlotinib,DMSO 终浓度为2.5%。加入ATP,开始磷酸化,在室温下进行8分钟,且持续震荡。加入吸取的反应混合物,激酶反应终止,使用冲洗 buffer冲洗4次。磷酸化的PGT与50 μL每孔 HRP联合的PY54 抗磷酸抗体[在封闭液(3% BSA 和0.05% Tween-20,溶于 PBS)中稀释到0.2 μg/mL]温育25分钟后,测量磷酸化的PGT。吸取移除抗体,使用冲洗buffer冲洗实验板4次。加入 TMB 微孔过氧化物酶底物,每孔50μL,进行比色分析,然后加入0.09 M 硫酸,每孔50 μL,终止反应。在450 nm处测定吸光值而测定磷酸化。
细胞实验:[3]
- 合并
  • Cell lines: HPAC细胞系和Capan-1细胞
  • Concentrations: 0.01 μM-10 μM
  • Incubation Time: 4天或6天
  • Method: 为了测评对细胞增殖的抑制作用,进行MTT实验。细胞在96孔板上在37oC下预温育,单独加入Erlotinib 和Gemcitabine,或者联合加入。在37oC下处理4天(HPAC细胞)或6天(Capan-1 细胞)后,每孔加入10 mL MTT,然后在37oC下温育2-5小时。使用Benchmark Plus 酶标仪在450和600 nm处测定每孔的光密度。每组每种药物实验独立重复进行2次或3次。按如下计算细胞增