Erlotinib HCl (OSI-744)

For research use only. Not for use in humans.

目录号:S1023 别名: CP358774, NSC 718781 中文名称:盐酸厄洛替尼

Erlotinib HCl (OSI-744) Chemical Structure

CAS No. 183319-69-9

Erlotinib HCl (OSI-744, CP358774, NSC 718781)是一种EGFR抑制剂,在无细胞试验中IC50为2 nM,对EGFR的选择性比对人c-Src或v-Abl高1000多倍。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1564.29 现货
RMB 1183.19 现货
RMB 2211.3 现货
RMB 3012.92 现货
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客户使用Selleck生产的Erlotinib HCl (OSI-744)发表文献440篇:

产品安全说明书

EGFR抑制剂选择性比较

生物活性

产品描述 Erlotinib HCl (OSI-744, CP358774, NSC 718781)是一种EGFR抑制剂,在无细胞试验中IC50为2 nM,对EGFR的选择性比对人c-Src或v-Abl高1000多倍。
靶点
HER1/EGFR [1]
(Cell-free assay)
2 nM
体外研究

Erlotinib作用于HNS人头部和颈部肿瘤细胞,有效抑制EGFR自磷酸化,HNS人头部和颈部肿瘤细胞是表达高水平EGFR的细胞系。[1] Erlotinib对SBC-5细胞增殖没有作用效果。相反, Erlotinib 显著抑制PC-9细胞增殖,这种作用存在剂量依赖性,PC-9细胞在EGFR基因第19外显子含缺失突变。Erlotinib处理也不会影响SBC-5细胞迁移。[2] Erlotinib 抑制HPAC细胞和Capan-1细胞生长, IC50 分别为1.1和3µM。10 uM Erlotinib 抑制EGFR在 Y845 (Src依赖性磷酸化) 和和Y1068(自磷酸化)位点磷酸化。[3] Erlotinib 只有作用于最敏感的细胞株时,抑制细胞外信号调节激酶, Akt, 和S6。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human SKBR3 cells M2P2XWZ2dmO2aX;uJIF{e2G7 MmHoTY5pcWKrdHnvckBw\iCKRWKyJIlvKGi3bXHuJHNMSlJ|IHPlcIx{KGK7IFjUVmYh[XO|YYmsJGlEPTB;MT64PUDPxE1w MoLGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl6MUW0NVIoRjF7OEG1OFEzRC:jPh?=
human A431 cells M4W0[WZ2dmO2aX;uJIF{e2G7 M1fYfmlvcGmkaYTpc44hd2ZiRVfGVkBqdiCqdX3hckBCPDNzIHPlcIx{KGK7IFjUVmYh[XO|YYmsJGlEPTB;MD60NkDPxE1w NVntXY5FRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm4NVU1OTJpPkG5PFE2PDF{PD;hQi=>
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PANC1 M1TOfWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXe2SnZ[PzJiaILz M37EXmdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJHBCVkNzIHPlcIx{KGGodHXyJFczKGi{czDifUBES0tvODDhd5NigSxiSVO1NEA:KDNwMTFOwG0v NEHyUWs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW0O|Y6OCd-Mk[1OFc3QTB:L3G+
SCC25 MWrBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MV;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFOFQ{K1JINmdGy|LDDJR|UxKD1iMz6zOEDPxE1w Mo\ZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzNEO3O|goRjJyMUSzO|c5RC:jPh?=
NCI-H358 MWnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MojYOFghcHK| MXrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE6FST3IN|U5KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkh[2OtODDhd5NigSxiSVO1NEA:KDNwOUGg{txONg>? NYqzPIN7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkeyN|Q5QDdpPkK3NlM1QDh5PD;hQi=>
COS7 NYGzW5p7TnWwY4Tpc44h[XO|YYm= NWnIOldOUW6qaXLpeIlwdiCxZjDoeY1idiCMQVuyJHY3OTeIIH31eIFvfCCneIDy[ZN{\WRiaX6gR29UPyClZXzsd{whUUN3MDC9JFQh|ryPLh?= MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF5OEeyNkc,OTdzN{i3NlI9N2F-
L3.6PL NETrRZhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUDyV3VUPzJiaILz NYjaNFNtT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVDNwNmDMJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCFQ1utPEBie3OjeTygTWM2OCB;IESg{txONg>? MlzDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3NEe2PVAoRjJ4NUS3OlkxRC:jPh?=
HT-29 NEf0W4lCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MVe3NkBpenN? NGjOVpFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjUMVI6KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gZ4VtdCCycn;sbYZmemG2aX;uJJVv\GW{IHj5dI95cWFiY3;u[Il1cW:wczDh[pRmeiB5MjDodpMh[nliU2LCJIF{e2G7LDDJR|UxKD1iND6zO{DPxE1w NE\uVFc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUS2PFA1PCd-MkW0OlgxPDR:L3G+
OVCAR3 M{THemFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NYXiXZJXPzJiaILz M2D4SGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iT2\DRXI{KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKGG|c3H5MEBKSzVyIE2gOE43KM7:TT6= MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV7OUWzNkc,OjZ3OUm1N|I9N2F-
Calu3 NUewXo94SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NIrFZ3Q4OiCqcoO= NH\PSFBCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFPhcJU{KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKgZox2\SCjc4PhfUwhUUN3MDC9JFQvPyEQvF2u NVXCR4dnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[1PVk2OzJpPkK2OVk6PTN{PD;hQi=>
hematopoietic progenitor cell NV33e45yT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4O3UWdzd3e2aDDpcohq[mm2aX;uJI9nKEqDS{KgWlYyP0ZibYX0ZY51KGW6cILld5NqdmdiaHXtZZRweG:rZYTpZ{Bxem:pZX7peI9zKGOnbHzzJIl{d2yjdHXkJIZzd21icH;sfYN6fGinbXnhJJZmemFicHH0bYVvfCCkeTDjc4xwdnliZn;ycYlv\yCjc4PhfUwhUUN3MDC9JFUh|ryPLh?= M37rS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUe4O|IzLz5zN{G3PFczOjxxYU6=
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N87 NIDsWGlHfW6ldHnvckBie3OjeR?= NX\DNnF4UW6qaXLpeIlwdiCxZjDFdoJDOiCrboTyZYNmdGy3bHHyJJBpd3OyaH;yfYxifGmxbjDpckBpfW2jbjDOPFch[2WubIOgZpkhTUyLU1GsJGlEPTBiPTC1MlIh|ryPLh?= NFL1bY49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEO0OlY2PSd-MkCzOFY3PTV:L3G+
NCI-H1975 MXLDfZRwfG:6aXPpeJkh[XO|YYm= M3P3ZlczKGi{cx?= MWjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDOR2kuUDF7N{WgZ4VtdHNiZYjwdoV{e2mwZzDFS2ZTKEx6NUjSM3Q4QTCPIH31eIFvfCCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPS53MTFOwG0v MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDRzMUGyN{c,OjR2MUGxNlM9N2F-
MRC5 NUPUTXdrSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NWTidIRlPzJiaILz NVPac4c5SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNVmM2KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKGG|c3H5MEBKSzVyIE2gOU45KM7:TT6= NFrRR4s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5PVU{Oid-Mk[1PVk2OzJ:L3G+
HepG2 NGLvfWxCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MkDROFghcHK| MXfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEincFeyJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB3Lkig{txONg>? MkixQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ6OU[3NFgoRjJ4OEm2O|A5RC:jPh?=
NCI-H358 M17tR2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 NHX0NGhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF7DTU1JOzV6IHPlcIx{KGGodHXyJIhzeyCkeTDBWHAh[2:wdHXueEBie3OjeTygTWM2OCB;IE[g{txONg>? MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF2M{e3PEc,OjBzNEO3O|g9N2F-
A549 MVvBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MXPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiYYPz[ZN{\WRiYYOgeoli[mynIHPlcIx{KGGodHXyJFQ5KGi{czDifUBES0t6IHHzd4F6NCCLQ{WwJF0hPi5{NjFOwG0v NVnTXXdFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[4O|k{OTRpPkK2PFc6OzF2PD;hQi=>
LNCAP M4HyXWN6fG:2b4jpZ4l1gSCjc4PhfS=> M{XrfFQh\GG7cx?= MWfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDMUmNCWCClZXzsd{Bi\nSncjC0JIRigXNiYomgdJJweGmmaYXtJIlw\GmmZTDzeIFqdmmwZz3iZZNm\CCobIXvdo9u\XS{aXOgZY5idHm|aYOsJGlEPTBiPTC2MlY{KM7:TT6= NUXi[FJmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxOlk3ODFpPkKyNVY6PjBzPD;hQi=>
MIAPaCa Mkf4SpVv[3Srb36gZZN{[Xl? M4XacGlvcGmkaYTpc44hd2ZiRWLCZlIheGixc4Doc5J6dGG2aX;uJIlvKGi3bXHuJG1KSVCjQ3GgZ4VtdHNiYomgSWxKW0FuIFnDOVAhRSB4LkezJO69VS5? MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODhzN{WyN{c,OjB6MUe1NlM9N2F-
NCI-H358 NI\GRpBCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MXfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE6FST3IN|U5KGOnbHzzJIF{e2W|c3XkJIF{KH[rYXLs[UBk\WyuczDh[pRmeiB2ODDodpMh[nliQ1PLPEBie3OjeTygTWM2OCB;IE[uPFUh|ryPLh?= NYW3W4M4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[4O|k{OTRpPkK2PFc6OzF2PD;hQi=>
NCI-H1975 NULYb29wSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M4nze|czKGi{cx?= MoHZRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCQQ1mtTFE6PzViY3XscJMh\XiycnXzd4lv\yCHR1\SJHQ4QTCPIH31eIFvfCCjZoTldkA4OiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwJF0hPi57IN88UU4> NUjvNXduRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSxPFM4PDJpPkK0NVg{PzR{PD;hQi=>
NCI-H1975 MVLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MV23NkBpenN? MlfTRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDn[YZqfGmwaXKtdoV{cXO2YX70JIh2dWGwIF7DTU1JOTl5NTDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliU2LCJIF{e2G7LDDJR|UxKD1iNz6wOkDPxE1w NEfDR|Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW2OVk3QSd-MkS1OlU6Pjl:L3G+
A549 M2PVeWN6fG:2b4jpZ4l1gSCjc4PhfS=> NIDHT3o1QCCqcoO= MlXYR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gO{4xQTlizszNMi=> NV7xd3BDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NFA5OzBpPkK0PVAxQDNyPD;hQi=>
A549 NGjLdlVCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MXm0PEBpenN? NY\4cJdESW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkh[2OtODDhd5NigSxiSVO1NEA:KDdwM{Wg{txONg>? NWTETZFKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkeyN|Q5QDdpPkK3NlM1QDh5PD;hQi=>
NCI-H1975 M4PNe2N6fG:2b4jpZ4l1gSCjc4PhfS=> MWW0PEBpenN? NEjEPYtEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBPS0lvSEG5O|Uh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEeuOFk5KM7:TT6= M{\KeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUCwPFMxLz5{NEmwNFg{ODxxYU6=
HCC827 M{fheGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NV[2ZZZJSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIR2M5OjdiY3XscJMh[W[2ZYKgbJJ{KGK7IFHUVEBkd262ZX70JIF{e2G7LDDJR|UxKD1iNz61JO69VS5? MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF2M{e3PEc,OjBzNEO3O|g9N2F-
A549 NU\ZNZpnSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NXjENFFYPzJiaILz MXHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJJBzd2yrZnXyZZRqd25idX7k[ZIhdm:{bX;4bYEh[2:wZHn0bY9veyCjZoTldkA4OiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwJF0hPy53OTFOwG0v NE\xWmo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUS2PFA1PCd-MkW0OlgxPDR:L3G+
BxPC3 MnTHRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M4HlS2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQojQR|Mh[2WubIOgZYZ1\XJiaILzJIJ6KEGWUDDjc451\W62IHHzd4F6NCCLQ{WwJF0hPy54IN88UU4> NFvmbGY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEG0N|c4QCd-MkCxOFM4Pzh:L3G+
NCI-H1975 NYjTTXoyTnWwY4Tpc44h[XO|YYm= NWPaTopXOiCqcoO= NXrR[HpOUW6qaXLpeIlwdiCxZjDFS2ZTKEx6NUjSM3Q6PzCPIHTveYJt\SCvdYThcpQheGixc4Doc5J6dGG2aX;uJIlvKGi3bXHuJG5EUS2KMUm3OUBk\WyuczDh[pRmeiB{IHjyd{BjgSCobIXvdoV{[2WwY3WgZZN{[XluIFnDOVAhRSB5Lk[g{txONg>? MoLHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7M{C5PVQoRjJ|OUOwPVk1RC:jPh?=
PCI35 NW\UblZVT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWS3NkBpenN? MUXHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDQR2k{PSClZXzsd{Bi\nSncjC3NkBpenNiYomgR2NMNThiYYPzZZktKEmFNUCgQUA4NjdizszNMi=> MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV2N{[5NEc,OjZ3NEe2PVA9N2F-
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A498 Mnu1RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MYq0PEBpenN? MXvBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF2OUigZ4VtdHNiZYjwdoV{e2mwZzDFS2ZTKGGwZDDTdoMh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFI2NjZizszNMi=> M3fTZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MUi4OlIxLz5{NkG4PFYzODxxYU6=
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MDA-MB-231 NXzCdmxXSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MojDO|IhcHK| Mnn1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRFGtUWIuOjNzIHPlcIx{KGmwY4XiZZRm\CCob4KgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFMxNjF{IN88UU4> M3TQT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUKzN|g{Lz5{OEmyN|M5OzxxYU6=
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MDA-MB-231 MkjwRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NXnHbVU5PDhiaILz M3LOV2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTJ|MTDj[YxteyCrbnP1ZoF1\WRiZn;yJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA{Oy52NjFOwG0v NEHxdGU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEmyN|M5Oyd-Mki5NlM{QDN:L3G+
MDA231 M2S4UmN6fG:2b4jpZ4l1gSCjc4PhfS=> MoDpOEBl[Xm| NV\1RW46S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDMkOxJINmdGy|IHHmeIVzKDRiZHH5d{BjgSCycn;wbYRqfW1iaX;kbYRmKHO2YXnubY5oNWKjc3XkJIZtfW:{b33leJJq[yCjbnHsfZNqeyxiSVO1NEA:KDN2LkWg{txONg>? NXq0U3RxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxOlk3ODFpPkKyNVY6PjBzPD;hQi=>
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HEK293 MoLiSpVv[3Srb36gZZN{[Xl? NVTEXFB1PSCvaX7z NV3hZm5lUW6qaXLpeIlwdiCxZjDoeY1idiCuaY\ldkBQSVSSMVKzJIV5eHKnc4Pl[EBqdiCKRVuyPVMhTmyyLVnuJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiCdM1jdSVE4NWKndHHHJJVxfGGtZTDpcoN2[mG2ZXSg[o9zKDVibXnud{BjgSC|Y3nueIltdGG2aX;uJINwfW62aX7nMEBMcSB;IESxJO69VSxiSVO1NEA:KDR2IN88UU4> MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV2MUC2PEc,OjJ3NEGwOlg9N2F-
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NCI-H23 NYHpd2hVS3m2b4TvfIlkcXS7IHHzd4F6 MVm0OkBpenN? MlrsR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUmNKNUh{MzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiNE[gbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IES5MlMh|ryPLh?= M4W4N|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MUO4NFI4Lz5{OUGzPFAzPzxxYU6=
polycythemia vera hematopoietic progenitor cell Mn\BS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYr0UIJiPSC3TR?= MlHnS5Jwf3SqIHnubIljcXSrb36gc4YhUkGNMjDWOlE4TiCvdYThcpQh\XiycnXzd4lv\yCqdX3hckBxd2y7Y4n0bIVucWFidnXyZUBp\W2jdH;wc4lmfGmlIIDyc4dmdmm2b4KgZ4VtdHNiYYSgOUB2VSCkeTDldpl1cHKxaXSgZpVze3RvZn;ycYlv\yC3bnn0JIF{e2G7LDDOWWxNKD1iTmXMUEDPxE1w NFnNdYQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G3PFczOid-MUexO|g4OjJ:L3G+
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