Pazopanib HCl

别名: GW786034 HCl 中文名称:盐酸帕佐帕尼

Pazopanib HCl是一种新型多靶点抑制剂,作用于VEGFR1VEGFR2VEGFR3,PDGFR,FGFR,c-Kit和c-fms,在无细胞试验中IC50分别是10 nM,30 nM,47 nM,84 nM,74 nM,140 nM和146 nM。Pazopanib 可诱导自噬II型细胞死亡。

Pazopanib HCl Chemical Structure

Pazopanib HCl Chemical Structure

CAS: 635702-64-6

规格 价格 库存 购买数量
10mM (1mL in DMSO) RMB 1565.32 现货
10mg RMB 1225.19 现货
25mg RMB 2231.51 现货
100mg RMB 3031.75 现货
1g RMB 7944.3 现货
更大包装 有超大折扣

400-668-6834

info@selleck.cn

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客户使用Selleck的Pazopanib HCl发表文献55

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批次: 纯度: 99.93%
99.88

Pazopanib HCl相关产品

相关信号通路图

VEGFR抑制剂选择性比较

细胞实验数据示例

细胞系 实验类型 给药浓度 孵育时间 活性描述 文献信息
HUVEC Antiangiogenic assay 0.1 uM 6 hrs Antiangiogenic activity in human HUVEC cells assessed as reduction in capillary-like tubular network formation at 0.1 uM after 6 hrs by phase-contrast microscopy 29787262
HUVEC Function assay 100 nM 2 hrs Inhibition of VEGF-stimulated VEGFR2 phosphorylation in human HUVEC cells at 100 nM preincubated for 2 hrs followed by VEGF stimulation by Western blot analysis 29787262
INA-6 Growth inhibitory assay 10 μg/mL inhibits MM Cell Growth 17164332
Dox40 Growth inhibitory assay 10 μg/mL inhibits MM Cell Growth 17164332
RPMI Growth inhibitory assay 10 μg/mL inhibits MM Cell Growth 17164332
MM.1R Growth inhibitory assay 10 μg/mL inhibits MM Cell Growth 17164332
MM.1S Growth inhibitory assay 10 μg/mL inhibits MM Cell Growth 17164332
OPM2 Growth inhibitory assay 10 μg/mL inhibits MM Cell Growth 17164332
U266 Growth inhibitory assay 10 μg/mL inhibits MM Cell Growth 17164332
MM.1S cytotoxicity assay 20 μg/mL inhibits MM Cell Survival 17164332
MM.1R cytotoxicity assay 20 μg/mL inhibits MM Cell Survival 17164332
RPMI cytotoxicity assay 20 μg/mL inhibits MM Cell Survival 17164332
Dox40 cytotoxicity assay 20 μg/mL inhibits MM Cell Survival 17164332
INA-6 cytotoxicity assay 20 μg/mL inhibits MM Cell Survival 17164332
OPM2 cytotoxicity assay 20 μg/mL inhibits MM Cell Survival 17164332
U266 cytotoxicity assay 20 μg/mL inhibits MM Cell Survival 17164332
HBMEC Growth inhibitory assay ~10 μM IC50=1 μM 21081656
HBMEC Function assay ~1 μM abrogates the phosphorylation of VEGFR2 with disruption of downstream PLCγ1 21081656
HBMEC Function assay ~1 μM disrupts the Ras-Raf-ERK pathway through decreased phosphorylated MEK1/2 and ERK1/2 21081656
HBMEC Function assay ~20 μM disrupts 50% of tube formation at 1 μM 21081656
MDA-MB-231 Growth inhibitory assay ~10 μM IC50=5 μM 21081656
MDA-MB-231 Function assay 0.5 μM inhibits the ERK1/2 signaling pathway 21081656
MDA-MB-231 Function assay 5 μM induces a cell-cycle arrest 21081656
J82 cytotoxicity assay ~10 μM IC50=24.57 μM 21529900
T24 cytotoxicity assay ~10 μM IC50=52.45 μM 21529900
HT1376 cytotoxicity assay ~10 μM IC50=28.21 μM 21529900
RT4 cytotoxicity assay ~10 μM IC50=5.14 μM 21529900
CRL1749 cytotoxicity assay ~10 μM IC50=22.69 μM 21529900
HTB9 cytotoxicity assay ~10 μM IC50=11.84 μM 21529900
Sup cytotoxicity assay ~10 μM IC50=53.32 μM 21529900
HTB3 cytotoxicity assay ~10 μM IC50=14.16 μM 21529900
CEC Function assay ~10 μg/mL down-regulates VEGF levels 21620822
RPE Function assay ~10 μg/mL down-regulates VEGF levels 21620822
CEC Function assay ~5 μg/mL blocks endothelial cell migration 21620822
5637 Autophagy assay 20 μM triggers the autophagic process 23887605
J82 Autophagy assay 20 μM triggers the autophagic process 23887605
5637 Function assay 20 μM induces lysosomal-dependent necrosis 23887605
J82 Function assay 20 μM induces lysosomal-dependent necrosis 23887605
5637 Function assay 20 μM induces lysosome alteration and inhibits CB activity 23887605
J82 Function assay 20 μM induces lysosome alteration and inhibits CB activity 23887605
KATO-II Growth inhibitory assay 5 μM blocks proliferation 25249557
OCUM-2M Growth inhibitory assay 5 μM blocks proliferation 25249557
SNU-16 Growth inhibitory assay 5 μM blocks proliferation 25249557
HSC-39 Growth inhibitory assay 5 μM blocks proliferation 25249557
KATO-II cytotoxicity assay ~10 μM IC50=0.1 to 2.0 μmol/L 25249557
OCUM-2M cytotoxicity assay ~10 μM IC50=0.1 to 2.0 μmol/L 25249557
SNU-16 cytotoxicity assay ~10 μM IC50=0.1 to 2.0 μmol/L 25249557
HSC-39 cytotoxicity assay ~10 μM IC50=0.1 to 2.0 μmol/L 25249557
NIH 3T3 Growth inhibitory assay ~10 μM inhibits cell growth and colony formation 25249557
KATO-III Function assay 1 μM induces cell-cycle arrest 25249557
OCUM-2M Function assay 1 μM induces cell-cycle arrest 25249557
KATO-III Apoptosis assay 1 μM induces apoptosis 25249557
OCUM-2M Apoptosis assay 1 μM induces apoptosis 25249557
KATO-III Function assay 1 μM inhibits FGFR2 phosphorylation and downstream signaling molecules 25249557
HT-29 Function assay 14 to 24 hrs Inhibition of RIPK1 in human HT-29 cells assessed as reduction in TNFalpha-induced necroptosis incubated for 14 to 24 hrs in presence of Smac mimetic and z-VAD-FMK by cell titer glo-based luminescence assay, IC50=0.873μM 31622096
MM Kinase assay inhibits VEGF-induced phosphorylation of flt1 17164332
SK-N-SH qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-SH cells 29435139
Rh41 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh41 cells 29435139
U-2 OS qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for U-2 OS cells 29435139
SK-N-MC qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-MC cells 29435139
MG 63 (6-TG R) qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells 29435139
OHS-50 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells 29435139
Rh18 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells 29435139
BT-12 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells 29435139
BT-12 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells 29435139
LAN-5 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells 29435139
Saos-2 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells 29435139
NB-EBc1 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells 29435139
SK-N-MC qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells 29435139
SK-N-MC qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells 29435139
SJ-GBM2 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells 29435139
A375P Antiproliferative assay Antiproliferative activity against human A375P cells in serum containing medium 18620382
HN5 Antiproliferative assay Antiproliferative activity against human HN5 cells in serum containing medium 18620382
HT29 Antiproliferative assay Antiproliferative activity against human HT29 cells in serum containing medium 18620382
MM.1S Function assay suppresses VEGF-Induced Endothelial Cell Proliferation and Migration. 17164332
MM.1R Function assay suppresses VEGF-Induced Endothelial Cell Proliferation and Migration. 17164332
Dox40 Function assay suppresses VEGF-Induced Endothelial Cell Proliferation and Migration. 17164332
OPM2 Function assay suppresses VEGF-Induced Endothelial Cell Proliferation and Migration. 17164332
5637 Growth inhibitory assay IC50=15.0 μM 23887605
J82 Growth inhibitory assay IC50=18.4 μM 23887605
EoL-1-cell Growth inhibition assay Inhibition of human EoL-1-cell cell growth in a cell viability assay, IC50=0.0000289μM. SANGER
AN3-CA Growth inhibition assay Inhibition of human AN3-CA cell growth in a cell viability assay, IC50=0.01005μM. SANGER
CGTH-W-1 Growth inhibition assay Inhibition of human CGTH-W-1 cell growth in a cell viability assay, IC50=0.04001μM. SANGER
GDM-1 Growth inhibition assay Inhibition of human GDM-1 cell growth in a cell viability assay, IC50=0.10399μM. SANGER
A204 Growth inhibition assay Inhibition of human A204 cell growth in a cell viability assay, IC50=0.10906μM. SANGER
G-402 Growth inhibition assay Inhibition of human G-402 cell growth in a cell viability assay, IC50=0.53184μM. SANGER
MFE-296 Growth inhibition assay Inhibition of human MFE-296 cell growth in a cell viability assay, IC50=0.59022μM. SANGER
NOS-1 Growth inhibition assay Inhibition of human NOS-1 cell growth in a cell viability assay, IC50=0.65987μM. SANGER
KG-1 Growth inhibition assay Inhibition of human KG-1 cell growth in a cell viability assay, IC50=0.71755μM. SANGER
HT55 Growth inhibition assay Inhibition of human HT55 cell growth in a cell viability assay, IC50=0.98781μM. SANGER
MG-63 Growth inhibition assay Inhibition of human MG-63 cell growth in a cell viability assay, IC50=1.00146μM. SANGER
CCF-STTG1 Growth inhibition assay Inhibition of human CCF-STTG1 cell growth in a cell viability assay, IC50=1.04981μM. SANGER
RT-112 Growth inhibition assay Inhibition of human RT-112 cell growth in a cell viability assay, IC50=1.10376μM. SANGER
MC-IXC Growth inhibition assay Inhibition of human MC-IXC cell growth in a cell viability assay, IC50=1.11512μM. SANGER
HUTU-80 Growth inhibition assay Inhibition of human HUTU-80 cell growth in a cell viability assay, IC50=1.28103μM. SANGER
MV-4-11 Growth inhibition assay Inhibition of human MV-4-11 cell growth in a cell viability assay, IC50=1.34501μM. SANGER
LCLC-103H Growth inhibition assay Inhibition of human LCLC-103H cell growth in a cell viability assay, IC50=1.44549μM. SANGER
G-401 Growth inhibition assay Inhibition of human G-401 cell growth in a cell viability assay, IC50=1.46421μM. SANGER
A704 Growth inhibition assay Inhibition of human A704 cell growth in a cell viability assay, IC50=1.60323μM. SANGER
ESS-1 Growth inhibition assay Inhibition of human ESS-1 cell growth in a cell viability assay, IC50=1.60396μM. SANGER
HLE Growth inhibition assay Inhibition of human HLE cell growth in a cell viability assay, IC50=1.63804μM. SANGER
NY Growth inhibition assay Inhibition of human NY cell growth in a cell viability assay, IC50=1.84821μM. SANGER
A427 Growth inhibition assay Inhibition of human A427 cell growth in a cell viability assay, IC50=1.98075μM. SANGER
SK-N-DZ Growth inhibition assay Inhibition of human SK-N-DZ cell growth in a cell viability assay, IC50=2.02381μM. SANGER
J82 Growth inhibition assay Inhibition of human J82 cell growth in a cell viability assay, IC50=2.06088μM. SANGER
GI-1 Growth inhibition assay Inhibition of human GI-1 cell growth in a cell viability assay, IC50=2.22951μM. SANGER
NCI-H716 Growth inhibition assay Inhibition of human NCI-H716 cell growth in a cell viability assay, IC50=2.31633μM. SANGER
SF126 Growth inhibition assay Inhibition of human SF126 cell growth in a cell viability assay, IC50=2.47459μM. SANGER
H4 Growth inhibition assay Inhibition of human H4 cell growth in a cell viability assay, IC50=2.51262μM. SANGER
LB831-BLC Growth inhibition assay Inhibition of human LB831-BLC cell growth in a cell viability assay, IC50=2.54566μM. SANGER
HCC1395 Growth inhibition assay Inhibition of human HCC1395 cell growth in a cell viability assay, IC50=2.58156μM. SANGER
LK-2 Growth inhibition assay Inhibition of human LK-2 cell growth in a cell viability assay, IC50=2.64569μM. SANGER
G-361 Growth inhibition assay Inhibition of human G-361 cell growth in a cell viability assay, IC50=3.04082μM. SANGER
NCI-H2342 Growth inhibition assay Inhibition of human NCI-H2342 cell growth in a cell viability assay, IC50=3.13316μM. SANGER
SK-LU-1 Growth inhibition assay Inhibition of human SK-LU-1 cell growth in a cell viability assay, IC50=3.18767μM. SANGER
IGROV-1 Growth inhibition assay Inhibition of human IGROV-1 cell growth in a cell viability assay, IC50=3.24713μM. SANGER
EB2 Growth inhibition assay Inhibition of human EB2 cell growth in a cell viability assay, IC50=3.28168μM. SANGER
CAL-54 Growth inhibition assay Inhibition of human CAL-54 cell growth in a cell viability assay, IC50=3.28367μM. SANGER
OCUB-M Growth inhibition assay Inhibition of human OCUB-M cell growth in a cell viability assay, IC50=3.31368μM. SANGER
LB1047-RCC Growth inhibition assay Inhibition of human LB1047-RCC cell growth in a cell viability assay, IC50=3.53164μM. SANGER
Daudi Growth inhibition assay Inhibition of human Daudi cell growth in a cell viability assay, IC50=3.66219μM. SANGER
A172 Growth inhibition assay Inhibition of human A172 cell growth in a cell viability assay, IC50=3.7379μM. SANGER
KGN Growth inhibition assay Inhibition of human KGN cell growth in a cell viability assay, IC50=4.06709μM. SANGER
SNG-M Growth inhibition assay Inhibition of human SNG-M cell growth in a cell viability assay, IC50=4.08669μM. SANGER
SW1710 Growth inhibition assay Inhibition of human SW1710 cell growth in a cell viability assay, IC50=4.47318μM. SANGER
Daoy Growth inhibition assay Inhibition of human Daoy cell growth in a cell viability assay, IC50=4.77949μM. SANGER
DMS-273 Growth inhibition assay Inhibition of human DMS-273 cell growth in a cell viability assay, IC50=4.96202μM. SANGER
KU812 Growth inhibition assay Inhibition of human KU812 cell growth in a cell viability assay, IC50=5.37812μM. SANGER
NCI-H727 Growth inhibition assay Inhibition of human NCI-H727 cell growth in a cell viability assay, IC50=5.40901μM. SANGER
P30-OHK Growth inhibition assay Inhibition of human P30-OHK cell growth in a cell viability assay, IC50=5.4694μM. SANGER
MIA-PaCa-2 Growth inhibition assay Inhibition of human MIA-PaCa-2 cell growth in a cell viability assay, IC50=5.60466μM. SANGER
TT Growth inhibition assay Inhibition of human TT cell growth in a cell viability assay, IC50=5.6624μM. SANGER
DK-MG Growth inhibition assay Inhibition of human DK-MG cell growth in a cell viability assay, IC50=5.72028μM. SANGER
GB-1 Growth inhibition assay Inhibition of human GB-1 cell growth in a cell viability assay, IC50=5.73434μM. SANGER
NCI-H520 Growth inhibition assay Inhibition of human NCI-H520 cell growth in a cell viability assay, IC50=5.73435μM. SANGER
WM-115 Growth inhibition assay Inhibition of human WM-115 cell growth in a cell viability assay, IC50=5.75644μM. SANGER
CAL-72 Growth inhibition assay Inhibition of human CAL-72 cell growth in a cell viability assay, IC50=5.9381μM. SANGER
NCI-H1573 Growth inhibition assay Inhibition of human NCI-H1573 cell growth in a cell viability assay, IC50=5.96542μM. SANGER
ES6 Growth inhibition assay Inhibition of human ES6 cell growth in a cell viability assay, IC50=6.02688μM. SANGER
TE-8 Growth inhibition assay Inhibition of human TE-8 cell growth in a cell viability assay, IC50=6.16473μM. SANGER
GAMG Growth inhibition assay Inhibition of human GAMG cell growth in a cell viability assay, IC50=6.17776μM. SANGER
HGC-27 Growth inhibition assay Inhibition of human HGC-27 cell growth in a cell viability assay, IC50=6.2015μM. SANGER
CTV-1 Growth inhibition assay Inhibition of human CTV-1 cell growth in a cell viability assay, IC50=6.20903μM. SANGER
NCI-H810 Growth inhibition assay Inhibition of human NCI-H810 cell growth in a cell viability assay, IC50=6.31365μM. SANGER
NMC-G1 Growth inhibition assay Inhibition of human NMC-G1 cell growth in a cell viability assay, IC50=6.55237μM. SANGER
SNB75 Growth inhibition assay Inhibition of human SNB75 cell growth in a cell viability assay, IC50=6.56939μM. SANGER
SK-MES-1 Growth inhibition assay Inhibition of human SK-MES-1 cell growth in a cell viability assay, IC50=6.8663μM. SANGER
MZ2-MEL Growth inhibition assay Inhibition of human MZ2-MEL cell growth in a cell viability assay, IC50=6.93016μM. SANGER
TE-15 Growth inhibition assay Inhibition of human TE-15 cell growth in a cell viability assay, IC50=7.16924μM. SANGER
S-117 Growth inhibition assay Inhibition of human S-117 cell growth in a cell viability assay, IC50=7.57924μM. SANGER
HuH-7 Growth inhibition assay Inhibition of human HuH-7 cell growth in a cell viability assay, IC50=7.69384μM. SANGER
CAS-1 Growth inhibition assay Inhibition of human CAS-1 cell growth in a cell viability assay, IC50=7.76339μM. SANGER
D-502MG Growth inhibition assay Inhibition of human D-502MG cell growth in a cell viability assay, IC50=7.78222μM. SANGER
IA-LM Growth inhibition assay Inhibition of human IA-LM cell growth in a cell viability assay, IC50=7.93364μM. SANGER
CAKI-1 Growth inhibition assay Inhibition of human CAKI-1 cell growth in a cell viability assay, IC50=8.28831μM. SANGER
KYSE-70 Growth inhibition assay Inhibition of human KYSE-70 cell growth in a cell viability assay, IC50=8.45447μM. SANGER
HCC1569 Growth inhibition assay Inhibition of human HCC1569 cell growth in a cell viability assay, IC50=8.46556μM. SANGER
SR Growth inhibition assay Inhibition of human SR cell growth in a cell viability assay, IC50=8.70202μM. SANGER
SH-4 Growth inhibition assay Inhibition of human SH-4 cell growth in a cell viability assay, IC50=8.73653μM. SANGER
SW954 Growth inhibition assay Inhibition of human SW954 cell growth in a cell viability assay, IC50=8.75347μM. SANGER
MPP-89 Growth inhibition assay Inhibition of human MPP-89 cell growth in a cell viability assay, IC50=8.7782μM. SANGER
IST-MEL1 Growth inhibition assay Inhibition of human IST-MEL1 cell growth in a cell viability assay, IC50=8.91086μM. SANGER
EFM-19 Growth inhibition assay Inhibition of human EFM-19 cell growth in a cell viability assay, IC50=8.92276μM. SANGER
KS-1 Growth inhibition assay Inhibition of human KS-1 cell growth in a cell viability assay, IC50=8.97341μM. SANGER
786-0 Growth inhibition assay Inhibition of human 786-0 cell growth in a cell viability assay, IC50=8.99139μM. SANGER
SK-OV-3 Growth inhibition assay Inhibition of human SK-OV-3 cell growth in a cell viability assay, IC50=9.01236μM. SANGER
C3A Growth inhibition assay Inhibition of human C3A cell growth in a cell viability assay, IC50=9.12939μM. SANGER
NCI-H358 Growth inhibition assay Inhibition of human NCI-H358 cell growth in a cell viability assay, IC50=9.15929μM. SANGER
NCI-H2170 Growth inhibition assay Inhibition of human NCI-H2170 cell growth in a cell viability assay, IC50=9.20801μM. SANGER
HMV-II Growth inhibition assay Inhibition of human HMV-II cell growth in a cell viability assay, IC50=9.34065μM. SANGER
SW1088 Growth inhibition assay Inhibition of human SW1088 cell growth in a cell viability assay, IC50=9.56098μM. SANGER
RS4-11 Growth inhibition assay Inhibition of human RS4-11 cell growth in a cell viability assay, IC50=9.71841μM. SANGER
SNU-423 Growth inhibition assay Inhibition of human SNU-423 cell growth in a cell viability assay, IC50=9.87712μM. SANGER
A431 Growth inhibition assay Inhibition of human A431 cell growth in a cell viability assay, IC50=9.88028μM. SANGER
BB65-RCC Growth inhibition assay Inhibition of human BB65-RCC cell growth in a cell viability assay, IC50=10.0298μM. SANGER
M059J Growth inhibition assay Inhibition of human M059J cell growth in a cell viability assay, IC50=10.2576μM. SANGER
Calu-3 Growth inhibition assay Inhibition of human Calu-3 cell growth in a cell viability assay, IC50=10.5161μM. SANGER
LAMA-84 Growth inhibition assay Inhibition of human LAMA-84 cell growth in a cell viability assay, IC50=10.6573μM. SANGER
ACHN Growth inhibition assay Inhibition of human ACHN cell growth in a cell viability assay, IC50=10.6743μM. SANGER
SW1990 Growth inhibition assay Inhibition of human SW1990 cell growth in a cell viability assay, IC50=10.7009μM. SANGER
LC-2-ad Growth inhibition assay Inhibition of human LC-2-ad cell growth in a cell viability assay, IC50=10.7475μM. SANGER
U-698-M Growth inhibition assay Inhibition of human U-698-M cell growth in a cell viability assay, IC50=10.9926μM. SANGER
A2780 Growth inhibition assay Inhibition of human A2780 cell growth in a cell viability assay, IC50=11.0963μM. SANGER
VA-ES-BJ Growth inhibition assay Inhibition of human VA-ES-BJ cell growth in a cell viability assay, IC50=11.1909μM. SANGER
A253 Growth inhibition assay Inhibition of human A253 cell growth in a cell viability assay, IC50=11.3911μM. SANGER
NCI-H2087 Growth inhibition assay Inhibition of human NCI-H2087 cell growth in a cell viability assay, IC50=11.7288μM. SANGER
NTERA-S-cl-D1 Growth inhibition assay Inhibition of human NTERA-S-cl-D1 cell growth in a cell viability assay, IC50=11.7718μM. SANGER
TE-12 Growth inhibition assay Inhibition of human TE-12 cell growth in a cell viability assay, IC50=11.8178μM. SANGER
LNCaP-Clone-FGC Growth inhibition assay Inhibition of human LNCaP-Clone-FGC cell growth in a cell viability assay, IC50=12.358μM. SANGER
HT-1376 Growth inhibition assay Inhibition of human HT-1376 cell growth in a cell viability assay, IC50=12.3595μM. SANGER
LB2518-MEL Growth inhibition assay Inhibition of human LB2518-MEL cell growth in a cell viability assay, IC50=12.4325μM. SANGER
QIMR-WIL Growth inhibition assay Inhibition of human QIMR-WIL cell growth in a cell viability assay, IC50=12.7363μM. SANGER
SF268 Growth inhibition assay Inhibition of human SF268 cell growth in a cell viability assay, IC50=12.9423μM. SANGER
MES-SA Growth inhibition assay Inhibition of human MES-SA cell growth in a cell viability assay, IC50=13.2346μM. SANGER
BPH-1 Growth inhibition assay Inhibition of human BPH-1 cell growth in a cell viability assay, IC50=13.2694μM. SANGER
CA46 Growth inhibition assay Inhibition of human CA46 cell growth in a cell viability assay, IC50=13.3899μM. SANGER
LB373-MEL-D Growth inhibition assay Inhibition of human LB373-MEL-D cell growth in a cell viability assay, IC50=13.4353μM. SANGER
NCI-H1755 Growth inhibition assay Inhibition of human NCI-H1755 cell growth in a cell viability assay, IC50=13.5203μM. SANGER
NCI-H1581 Growth inhibition assay Inhibition of human NCI-H1581 cell growth in a cell viability assay, IC50=13.742μM. SANGER
SNU-387 Growth inhibition assay Inhibition of human SNU-387 cell growth in a cell viability assay, IC50=13.9744μM. SANGER
HCC1419 Growth inhibition assay Inhibition of human HCC1419 cell growth in a cell viability assay, IC50=14.1325μM. SANGER
TE-9 Growth inhibition assay Inhibition of human TE-9 cell growth in a cell viability assay, IC50=14.5343μM. SANGER
LCLC-97TM1 Growth inhibition assay Inhibition of human LCLC-97TM1 cell growth in a cell viability assay, IC50=14.5912μM. SANGER
BC-1 Growth inhibition assay Inhibition of human BC-1 cell growth in a cell viability assay, IC50=14.6038μM. SANGER
DU-145 Growth inhibition assay Inhibition of human DU-145 cell growth in a cell viability assay, IC50=14.7605μM. SANGER
KARPAS-45 Growth inhibition assay Inhibition of human KARPAS-45 cell growth in a cell viability assay, IC50=15.1099μM. SANGER
SW684 Growth inhibition assay Inhibition of human SW684 cell growth in a cell viability assay, IC50=15.1418μM. SANGER
HCC2218 Growth inhibition assay Inhibition of human HCC2218 cell growth in a cell viability assay, IC50=15.1714μM. SANGER
EW-13 Growth inhibition assay Inhibition of human EW-13 cell growth in a cell viability assay, IC50=15.8055μM. SANGER
D-392MG Growth inhibition assay Inhibition of human D-392MG cell growth in a cell viability assay, IC50=15.8277μM. SANGER
PSN1 Growth inhibition assay Inhibition of human PSN1 cell growth in a cell viability assay, IC50=15.8665μM. SANGER
Saos-2 Growth inhibition assay Inhibition of human Saos-2 cell growth in a cell viability assay, IC50=15.9353μM. SANGER
COLO-679 Growth inhibition assay Inhibition of human COLO-679 cell growth in a cell viability assay, IC50=16.1233μM. SANGER
PC-14 Growth inhibition assay Inhibition of human PC-14 cell growth in a cell viability assay, IC50=16.4902μM. SANGER
CAL-85-1 Growth inhibition assay Inhibition of human CAL-85-1 cell growth in a cell viability assay, IC50=16.5837μM. SANGER
AU565 Growth inhibition assay Inhibition of human AU565 cell growth in a cell viability assay, IC50=16.7598μM. SANGER
A2058 Growth inhibition assay Inhibition of human A2058 cell growth in a cell viability assay, IC50=16.8504μM. SANGER
NH-12 Growth inhibition assay Inhibition of human NH-12 cell growth in a cell viability assay, IC50=17.5557μM. SANGER
Hs-578-T Growth inhibition assay Inhibition of human Hs-578-T cell growth in a cell viability assay, IC50=17.6584μM. SANGER
RXF393 Growth inhibition assay Inhibition of human RXF393 cell growth in a cell viability assay, IC50=17.8039μM. SANGER
COLO-741 Growth inhibition assay Inhibition of human COLO-741 cell growth in a cell viability assay, IC50=18.1083μM. SANGER
NCI-H1355 Growth inhibition assay Inhibition of human NCI-H1355 cell growth in a cell viability assay, IC50=18.1318μM. SANGER
GI-ME-N Growth inhibition assay Inhibition of human GI-ME-N cell growth in a cell viability assay, IC50=18.453μM. SANGER
MEL-HO Growth inhibition assay Inhibition of human MEL-HO cell growth in a cell viability assay, IC50=18.9753μM. SANGER
SW982 Growth inhibition assay Inhibition of human SW982 cell growth in a cell viability assay, IC50=19.8406μM. SANGER
MONO-MAC-6 Growth inhibition assay Inhibition of human MONO-MAC-6 cell growth in a cell viability assay, IC50=19.9061μM. SANGER
MFH-ino Growth inhibition assay Inhibition of human MFH-ino cell growth in a cell viability assay, IC50=20.2037μM. SANGER
BEN Growth inhibition assay Inhibition of human BEN cell growth in a cell viability assay, IC50=20.3128μM. SANGER
HT-144 Growth inhibition assay Inhibition of human HT-144 cell growth in a cell viability assay, IC50=20.3697μM. SANGER
DoTc2-4510 Growth inhibition assay Inhibition of human DoTc2-4510 cell growth in a cell viability assay, IC50=20.7966μM. SANGER
NCI-H522 Growth inhibition assay Inhibition of human NCI-H522 cell growth in a cell viability assay, IC50=20.8971μM. SANGER
NCI-H1299 Growth inhibition assay Inhibition of human NCI-H1299 cell growth in a cell viability assay, IC50=21.167μM. SANGER
CAL-12T Growth inhibition assay Inhibition of human CAL-12T cell growth in a cell viability assay, IC50=21.2435μM. SANGER
CTB-1 Growth inhibition assay Inhibition of human CTB-1 cell growth in a cell viability assay, IC50=21.6855μM. SANGER
COR-L105 Growth inhibition assay Inhibition of human COR-L105 cell growth in a cell viability assay, IC50=21.7949μM. SANGER
NCI-H1650 Growth inhibition assay Inhibition of human NCI-H1650 cell growth in a cell viability assay, IC50=21.8133μM. SANGER
SK-MEL-3 Growth inhibition assay Inhibition of human SK-MEL-3 cell growth in a cell viability assay, IC50=21.9788μM. SANGER
697 Growth inhibition assay Inhibition of human 697 cell growth in a cell viability assay, IC50=22.0402μM. SANGER
NEC8 Growth inhibition assay Inhibition of human NEC8 cell growth in a cell viability assay, IC50=22.1998μM. SANGER
ACN Growth inhibition assay Inhibition of human ACN cell growth in a cell viability assay, IC50=22.4965μM. SANGER
MHH-PREB-1 Growth inhibition assay Inhibition of human MHH-PREB-1 cell growth in a cell viability assay, IC50=22.5088μM. SANGER
RPMI-6666 Growth inhibition assay Inhibition of human RPMI-6666 cell growth in a cell viability assay, IC50=22.5905μM. SANGER
BB30-HNC Growth inhibition assay Inhibition of human BB30-HNC cell growth in a cell viability assay, IC50=23.539μM. SANGER
HOS Growth inhibition assay Inhibition of human HOS cell growth in a cell viability assay, IC50=23.8014μM. SANGER
OVCAR-4 Growth inhibition assay Inhibition of human OVCAR-4 cell growth in a cell viability assay, IC50=23.984μM. SANGER
SK-HEP-1 Growth inhibition assay Inhibition of human SK-HEP-1 cell growth in a cell viability assay, IC50=24.0791μM. SANGER
OS-RC-2 Growth inhibition assay Inhibition of human OS-RC-2 cell growth in a cell viability assay, IC50=24.0858μM. SANGER
MKN1 Growth inhibition assay Inhibition of human MKN1 cell growth in a cell viability assay, IC50=24.1401μM. SANGER
NCI-H510A Growth inhibition assay Inhibition of human NCI-H510A cell growth in a cell viability assay, IC50=24.5517μM. SANGER
DBTRG-05MG Growth inhibition assay Inhibition of human DBTRG-05MG cell growth in a cell viability assay, IC50=25.014μM. SANGER
SW13 Growth inhibition assay Inhibition of human SW13 cell growth in a cell viability assay, IC50=25.0254μM. SANGER
HuO-3N1 Growth inhibition assay Inhibition of human HuO-3N1 cell growth in a cell viability assay, IC50=25.2535μM. SANGER
U-2-OS Growth inhibition assay Inhibition of human U-2-OS cell growth in a cell viability assay, IC50=25.5982μM. SANGER
PANC-10-05 Growth inhibition assay Inhibition of human PANC-10-05 cell growth in a cell viability assay, IC50=25.8389μM. SANGER
NUGC-3 Growth inhibition assay Inhibition of human NUGC-3 cell growth in a cell viability assay, IC50=26.0051μM. SANGER
MZ1-PC Growth inhibition assay Inhibition of human MZ1-PC cell growth in a cell viability assay, IC50=26.2821μM. SANGER
U-118-MG Growth inhibition assay Inhibition of human U-118-MG cell growth in a cell viability assay, IC50=26.3272μM. SANGER
NCI-H1703 Growth inhibition assay Inhibition of human NCI-H1703 cell growth in a cell viability assay, IC50=26.4593μM. SANGER
HT-1080 Growth inhibition assay Inhibition of human HT-1080 cell growth in a cell viability assay, IC50=26.6211μM. SANGER
EFO-21 Growth inhibition assay Inhibition of human EFO-21 cell growth in a cell viability assay, IC50=26.7536μM. SANGER
TK10 Growth inhibition assay Inhibition of human TK10 cell growth in a cell viability assay, IC50=27.1653μM. SANGER
ES1 Growth inhibition assay Inhibition of human ES1 cell growth in a cell viability assay, IC50=27.6673μM. SANGER
DMS-153 Growth inhibition assay Inhibition of human DMS-153 cell growth in a cell viability assay, IC50=28.2498μM. SANGER
KYSE-270 Growth inhibition assay Inhibition of human KYSE-270 cell growth in a cell viability assay, IC50=28.3533μM. SANGER
MLMA Growth inhibition assay Inhibition of human MLMA cell growth in a cell viability assay, IC50=28.3719μM. SANGER
KURAMOCHI Growth inhibition assay Inhibition of human KURAMOCHI cell growth in a cell viability assay, IC50=28.5975μM. SANGER
NCI-H2347 Growth inhibition assay Inhibition of human NCI-H2347 cell growth in a cell viability assay, IC50=28.5994μM. SANGER
MCF7 Growth inhibition assay Inhibition of human MCF7 cell growth in a cell viability assay, IC50=28.7093μM. SANGER
HOP-92 Growth inhibition assay Inhibition of human HOP-92 cell growth in a cell viability assay, IC50=28.9327μM. SANGER
REH Growth inhibition assay Inhibition of human REH cell growth in a cell viability assay, IC50=28.9422μM. SANGER
RT4 Growth inhibition assay Inhibition of human RT4 cell growth in a cell viability assay, IC50=29.2259μM. SANGER
HT-1197 Growth inhibition assay Inhibition of human HT-1197 cell growth in a cell viability assay, IC50=29.2582μM. SANGER
BL-41 Growth inhibition assay Inhibition of human BL-41 cell growth in a cell viability assay, IC50=29.6923μM. SANGER
IST-MES1 Growth inhibition assay Inhibition of human IST-MES1 cell growth in a cell viability assay, IC50=29.8144μM. SANGER
MOLT-16 Growth inhibition assay Inhibition of human MOLT-16 cell growth in a cell viability assay, IC50=30.3744μM. SANGER
GAK Growth inhibition assay Inhibition of human GAK cell growth in a cell viability assay, IC50=31.1007μM. SANGER
RD Growth inhibition assay Inhibition of human RD cell growth in a cell viability assay, IC50=31.2473μM. SANGER
COR-L23 Growth inhibition assay Inhibition of human COR-L23 cell growth in a cell viability assay, IC50=31.3023μM. SANGER
Capan-2 Growth inhibition assay Inhibition of human Capan-2 cell growth in a cell viability assay, IC50=31.6669μM. SANGER
ALL-PO Growth inhibition assay Inhibition of human ALL-PO cell growth in a cell viability assay, IC50=31.9592μM. SANGER
BCPAP Growth inhibition assay Inhibition of human BCPAP cell growth in a cell viability assay, IC50=32.4534μM. SANGER
OVCAR-3 Growth inhibition assay Inhibition of human OVCAR-3 cell growth in a cell viability assay, IC50=32.6497μM. SANGER
NKM-1 Growth inhibition assay Inhibition of human NKM-1 cell growth in a cell viability assay, IC50=33.1404μM. SANGER
647-V Growth inhibition assay Inhibition of human 647-V cell growth in a cell viability assay, IC50=33.9321μM. SANGER
ES5 Growth inhibition assay Inhibition of human ES5 cell growth in a cell viability assay, IC50=34.9282μM. SANGER
A3-KAW Growth inhibition assay Inhibition of human A3-KAW cell growth in a cell viability assay, IC50=35.5285μM. SANGER
ChaGo-K-1 Growth inhibition assay Inhibition of human ChaGo-K-1 cell growth in a cell viability assay, IC50=35.5964μM. SANGER
NALM-6 Growth inhibition assay Inhibition of human NALM-6 cell growth in a cell viability assay, IC50=35.6045μM. SANGER
8-MG-BA Growth inhibition assay Inhibition of human 8-MG-BA cell growth in a cell viability assay, IC50=35.9586μM. SANGER
BL-70 Growth inhibition assay Inhibition of human BL-70 cell growth in a cell viability assay, IC50=36.8348μM. SANGER
MRK-nu-1 Growth inhibition assay Inhibition of human MRK-nu-1 cell growth in a cell viability assay, IC50=37.0227μM. SANGER
COR-L88 Growth inhibition assay Inhibition of human COR-L88 cell growth in a cell viability assay, IC50=37.2976μM. SANGER
MDA-MB-415 Growth inhibition assay Inhibition of human MDA-MB-415 cell growth in a cell viability assay, IC50=38.6783μM. SANGER
Becker Growth inhibition assay Inhibition of human Becker cell growth in a cell viability assay, IC50=39.1235μM. SANGER
NCI-H2452 Growth inhibition assay Inhibition of human NCI-H2452 cell growth in a cell viability assay, IC50=39.1445μM. SANGER
SW626 Growth inhibition assay Inhibition of human SW626 cell growth in a cell viability assay, IC50=39.1841μM. SANGER
SAS Growth inhibition assay Inhibition of human SAS cell growth in a cell viability assay, IC50=39.5476μM. SANGER
DMS-53 Growth inhibition assay Inhibition of human DMS-53 cell growth in a cell viability assay, IC50=39.7553μM. SANGER
CP66-MEL Growth inhibition assay Inhibition of human CP66-MEL cell growth in a cell viability assay, IC50=39.7602μM. SANGER
NCI-H2405 Growth inhibition assay Inhibition of human NCI-H2405 cell growth in a cell viability assay, IC50=40.1926μM. SANGER
MC-CAR Growth inhibition assay Inhibition of human MC-CAR cell growth in a cell viability assay, IC50=40.2471μM. SANGER
CAL-120 Growth inhibition assay Inhibition of human CAL-120 cell growth in a cell viability assay, IC50=40.9723μM. SANGER
GCT Growth inhibition assay Inhibition of human GCT cell growth in a cell viability assay, IC50=41.2626μM. SANGER
A375 Growth inhibition assay Inhibition of human A375 cell growth in a cell viability assay, IC50=41.5395μM. SANGER
MEG-01 Growth inhibition assay Inhibition of human MEG-01 cell growth in a cell viability assay, IC50=41.6116μM. SANGER
NCI-H2122 Growth inhibition assay Inhibition of human NCI-H2122 cell growth in a cell viability assay, IC50=41.97μM. SANGER
RPMI-2650 Growth inhibition assay Inhibition of human RPMI-2650 cell growth in a cell viability assay, IC50=43.4784μM. SANGER
8305C Growth inhibition assay Inhibition of human 8305C cell growth in a cell viability assay, IC50=43.7675μM. SANGER
NCI-H1395 Growth inhibition assay Inhibition of human NCI-H1395 cell growth in a cell viability assay, IC50=44.1055μM. SANGER
EW-16 Growth inhibition assay Inhibition of human EW-16 cell growth in a cell viability assay, IC50=44.1094μM. SANGER
T98G Growth inhibition assay Inhibition of human T98G cell growth in a cell viability assay, IC50=44.4245μM. SANGER
IST-SL2 Growth inhibition assay Inhibition of human IST-SL2 cell growth in a cell viability assay, IC50=44.9279μM. SANGER
NCI-H1651 Growth inhibition assay Inhibition of human NCI-H1651 cell growth in a cell viability assay, IC50=45.9208μM. SANGER
COR-L279 Growth inhibition assay Inhibition of human COR-L279 cell growth in a cell viability assay, IC50=46.2081μM. SANGER
YT Growth inhibition assay Inhibition of human YT cell growth in a cell viability assay, IC50=46.5067μM. SANGER
TE-11 Growth inhibition assay Inhibition of human TE-11 cell growth in a cell viability assay, IC50=46.7404μM. SANGER
C-33-A Growth inhibition assay Inhibition of human C-33-A cell growth in a cell viability assay, IC50=46.8197μM. SANGER
OVCAR-5 Growth inhibition assay Inhibition of human OVCAR-5 cell growth in a cell viability assay, IC50=47.2307μM. SANGER
PANC-03-27 Growth inhibition assay Inhibition of human PANC-03-27 cell growth in a cell viability assay, IC50=47.3513μM. SANGER
CaR-1 Growth inhibition assay Inhibition of human CaR-1 cell growth in a cell viability assay, IC50=48.2474μM. SANGER
SNU-449 Growth inhibition assay Inhibition of human SNU-449 cell growth in a cell viability assay, IC50=49.2285μM. SANGER
点击查看更多细胞系数据

生物活性

产品描述 Pazopanib HCl是一种新型多靶点抑制剂,作用于VEGFR1VEGFR2VEGFR3,PDGFR,FGFR,c-Kit和c-fms,在无细胞试验中IC50分别是10 nM,30 nM,47 nM,84 nM,74 nM,140 nM和146 nM。Pazopanib 可诱导自噬II型细胞死亡。
特性 Pazopanib是一个多激酶的抑制剂。
靶点
VEGFR1 [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
VEGFR3 [1]
(Cell-free assay)
FGFR [1]
(Cell-free assay)
PDGFR [1]
(Cell-free assay)
点击更多
10 nM 30 nM 47 nM 74 nM 84 nM
体外研究(In Vitro)
体外研究活性 在HUVEC细胞中,Pazopanib显著抑制VEGF诱导的VEGFR-2的磷酸化,IC50 为8nM [1]。 在所有滑膜肉瘤细胞系中Pazopanib都表现出了生长抑制作用,包括SYO-1和HS-SY-II细胞,这种抑制具有剂量依赖的特性。1µg/mL Pazopanib就可以抑制SYO-1和HS-SY-II细胞增殖,而5µg/mL Pazopanib可以让它们的增殖彻底受阻。 Pazopanib 会诱导滑膜肉瘤细胞周期停留在 G1期从而抑制它的生长。与对照的细胞相比,经过Pazopanib处理过的 SYO-1细胞中的AKTs, GSK-3β, JNKs, p70 S6激酶以及mTOR的磷酸化都受到了抑制[2]。在20 mg/mL 到 22.5 mg/mL的浓度之间,Pazopanib 使RPE细胞的生存能力逐渐下降[3]
激酶实验 激酶活性测定
通过杆状病毒表达系统纯化人源的VEGFR受体激酶1, 2和3的C端催化活性区域的GST融合蛋白,用这些蛋白在384孔微量滴定板上利用均相时间分辨荧光技术(HTRF)对VEGRF1,2和3的酶活性进行分析。首先将10 μL活化的VEGFR2激酶溶液[终浓度为1nM酶溶于0.1 M HEPES,pH 7.5,包含0.1 mg/mL BSA,300 μM DTT]加入10μL底物溶液[终浓度为360 nM多肽(生物素偶联的aminohexyl-EEEEYFELVAKKKK-NH2),75 μM ATP, 10 μM MgCl2],同时加入1 μL 溶解在DMSO中的Pazopanib。滴定板在室温条件下孵育1小时,然后加入20 μL 100 mM 的EDTA终止反应。终止之后,加入20μL HTRF试剂(终浓度为15 nM 链亲和素偶联的别藻蓝素,用0.1 mg/mL BSA, 0.1 M HEPES, pH 7.5稀释的1 nM铕标记的酪氨酸磷酸化抗体)孵育十分钟以上。使用Wallac Victor的时间分辨荧光仪测定665 nM处的荧光值,时间间隔为50 μs。
细胞实验 细胞系 HUVEC细胞
浓度 0 μM -10 μM
孵育时间 1 小时
方法

检测经过VEGF处理过的HUVEC细胞中VEGFR2的磷酸化水平。细胞按每板100万到150万个的密度培养在铺有I型胶原蛋白的10 cm平板上,培养基选用 Clonetics EGM-MV。培养24小时后, 将原来的培养基换成含有0.1% BSA和500 μg/mL hydrocortisone 的Clonetics EBM 培养基,对细胞进行过夜的血清饥饿处理。然后用不同浓度的 Pazopanib 处理细胞1小时, 随后用10 ng/mL 的VEGF 或者对照物处理细胞10分钟。将细胞溶解在裂解液中。用flk-1的抗体对VEGFR2进行免疫沉淀反应,随后进行SDS-聚丙烯酰胺凝胶电泳,然后用flk-1 或者 antiphosphotyrosine (anti-P-tyr-biotin)的抗体进行蛋白免疫印迹的检测。通过光密度法测量将VEGFR2的磷酸化水平量化并将总的VEGFR2水品标准化。

实验图片 检测方法 检测指标 实验图片 PMID
Western blot p53 / PUMA p-Akt / Akt p-VEGFR2 / p-c-Kit / p-PDGFRβ / FLT-3 27924057
Immunofluorescence YAP/TAZ 26199863
Growth inhibition assay Cell viability 27924057
体内研究(In Vivo)
体内研究活性 与没有经过Pazopanib或者仅用10 mg/kg的Pazopanib治疗的小鼠相比,经过30 mg/kg或者100 mg/kg Pazopanib治疗的小鼠其肿瘤症状明显减轻。Pazopanib治疗耐受性良好,各组小鼠之间体重没有发生明显差异[2]
动物实验 Animal Models 携带SYO-1细胞的免疫缺陷小鼠
Dosages 0 mg/kg, 10 mg/kg, 30 mg/kg或100 mg/kg
Administration 口服
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03850964 Recruiting
Hereditary Hemorrhagic Telangiectasia|Epistaxis|Anemia|Nosebleed|HHT
Cure HHT
May 8 2023 Phase 2|Phase 3
NCT05180695 Recruiting
Advanced Soft-tissue Sarcoma|Metastatic Soft-tissue Sarcoma
Centre Leon Berard|Novartis|National Cancer Institute France
April 15 2022 Phase 1|Phase 2
NCT04659343 Unknown status
Kidney Cancer|Renal Cell Carcinoma Metastatic|Drug Toxicity|Drug Side Effect|Drug Mechanism
Frede Donskov|Odense University Hospital|Herlev Hospital|Rigshospitalet Denmark|University of Aarhus
November 1 2020 --
NCT03735758 Terminated
Soft Tissue Sarcoma Adult
GWT-TUD GmbH
November 2 2018 Phase 4

化学信息&溶解度

分子量 473.98 分子式

C21H23N7O2S.HCl

CAS号 635702-64-6 SDF Download Pazopanib HCl SDF
Smiles CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N.Cl
储存条件(自收到货起)

体外溶解度
批次:

DMSO : 17 mg/mL ( 35.86 mM; DMSO吸湿会降低化合物溶解度,请使用新开封DMSO)

Water : Insoluble

Ethanol : Insoluble

摩尔浓度计算器

体内溶解度
批次:

现配现用,请按从左到右的顺序依次添加,澄清后再加入下一溶剂

动物体内配方计算器

实验计算

摩尔浓度计算器

质量 浓度 体积 分子量

动物体内配方计算器(澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)

mg/kg g μL

第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于μL DMSO溶液(母液浓度mg/mL,:如该浓度超过该批次药物DMSO溶解度,请先联系Selleck);

体内配方配制方法:μL DMSO母液,加入μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入μL ddH2O,混匀澄清。

体内配方配制方法:μL DMSO母液,加入μL Corn oil,混匀澄清。

注意:1. 首先保证母液是澄清的;
2.一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。

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