Fedratinib (TG101348)

For research use only. Not for use in humans.

目录号：S2736 别名： SAR302503 中文名称：费德拉替尼

Fedratinib (TG101348) Chemical Structure

CAS No. 936091-26-8

Fedratinib (SAR302503, TG101348)是一种选择性JAK2抑制剂，在无细胞试验中IC50为3 nM，作用于JAK2比作用于JAK1和JAK3选择性高35和334倍。Fedratinib也可抑制 FMS-like tyrosine kinase 3 (FLT3) 和 Ret (c-RET)，对应的IC50值分别为15 nM和48 nM。Fedratinib有潜在的抗肿瘤活性。Fedratinib可抑制细胞增殖并促进凋亡。Phase 2。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1812.56 现货
RMB 897.44 现货
RMB 1414.65 现货
RMB 3030.91 现货
RMB 4651.14 现货
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客户使用Selleck生产的Fedratinib (TG101348)发表文献48篇：

产品安全说明书

JAK抑制剂选择性比较

生物活性

产品描述 Fedratinib (SAR302503, TG101348)是一种选择性JAK2抑制剂，在无细胞试验中IC50为3 nM，作用于JAK2比作用于JAK1和JAK3选择性高35和334倍。Fedratinib也可抑制 FMS-like tyrosine kinase 3 (FLT3) 和 Ret (c-RET)，对应的IC50值分别为15 nM和48 nM。Fedratinib有潜在的抗肿瘤活性。Fedratinib可抑制细胞增殖并促进凋亡。Phase 2。
靶点
JAK2 [1]
(Cell-free assay)		 JAK2 (V617F) [1]
(Cell-free assay)		 FLT3 [1]
(Cell-free assay)		 RET [1]
(Cell-free assay)
3 nM 3 nM 15 nM 48 nM
体外研究

TG-101348也显著抑制JAK2 V617F, Flt3和Ret，IC50分别为3 nM, 15 nM和48 nM。TG101348对密切相关的JAK3的IC50高300倍以上，对JAK1和TYK2家族抑制效果不强。TG101348抑制有JAK2V617F突变的人红细胞白血病细胞系，以及一种表达人JAK2V617F（的Ba/F3 JAK2V617F）鼠前B细胞系的增殖，IC50分别是305 nM 和270 nM。G-101348也抑制亲本Ba/F3细胞的增殖至一般水平，IC50约为420 nM。TG101348降低STAT5磷酸化的浓度和抑制细胞增殖所需的浓度一致。TG101348以剂量依赖的方式诱导HEL和JAK2V617F Ba/F3细胞的凋亡。TG101348在浓度高达10 μM时对正常人真皮成纤维细胞没有促凋亡活性。[1] TG101348降低GATA-1的表达，这和erythroid-skewing JAK2V617F+祖细胞分化有关，并且抑制STAT5和GATA S310的磷酸化。[2] TG101348抑制HMC-1.1（KITV560G）细胞的增殖，活性低于HMC-1.2 (KITD816V, KITV560G)细胞，IC50分别为740 nM和407 nM。[3]
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
H1975 NXS2dpJKSXCxcITvd4l{KEG|c3H5 M4nJZlAvPS1{IN88US=> MYmxNk01QCCq MlTQSG1UVw>? MnLqbY5lfWOnczDhdI9xfG:|aYOgbY4h[m:2aDDkc5NmNSCjbnSgeIlu\S1iZHXw[Y5l\W62IH3hco5meg>? NGe2dnE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi2PVIyOCd-MkW4OlkzOTB:L3G+
H1650 MVjBdI9xfG:|aYOgRZN{[Xl? Mk\ENE42NTJizszN NWTCbVR7OTJvNEigbC=> Mn7uSG1UVw>? NV\JbHo4cW6mdXPld{BieG:ydH;zbZMhcW5iYn;0bEBld3OnLTDhcoQhfGmvZT2g[IVx\W6mZX70JI1idm6nch?= M3;VVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OE[5NlExLz5{NUi2PVIyODxxYU6=
H1975 M2nNeWZ2dmO2aX;uJGF{e2G7 MlL0NE4zPS1zIN88US=> M4Xnb|I1KGh? M2DG[mROW09? M1XuSIlvcGmkaYTzJIV5eHKnc4Ppc44hd2ZiYYDvdJRwe2m|LYLlcIF1\WRicILveIVqdiCEY3ytXGwtKEKlbD2yMEB{fXK4aY\pckwhYEmDUB?= MmW4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6NkmyNVAoRjJ3OE[5NlExRC:jPh?=
H1650 NEXa[2pHfW6ldHnvckBCe3OjeR?= NGPiToIxNjJ3LUGg{txO M2ni[FI1KGh? MWLEUXNQ NFHkZlFqdmirYnn0d{BmgHC{ZYPzbY9vKG:oIHHwc5B1d3Orcz3y[YxifGWmIIDyc5RmcW5iQnPsMXhNNCCEY3ytNkwhe3W{dnn2bY4tKFiLQWC= NUHrbpZKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4OlkzOTBpPkK1PFY6OjFyPD;hQi=>
H1975 M{\zO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4q3cFEh|ryP MnjNOFghcA>? M4fyfGROW09? MV\z[Y5{cXSrenXzJINmdGy|IITvJJRp\SCleYTveI95cWOrdImgc4Yh\XKub4Tpcolj NHnibHI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi2PVIyOCd-MkW4OlkzOTB:L3G+
H1650 NI\0UZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknNNUDPxE1? NHzpPHY1QCCq MYPEUXNQ MYnz[Y5{cXSrenXzJINmdGy|IITvJJRp\SCleYTveI95cWOrdImgc4Yh\XKub4Tpcolj MmTKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6NkmyNVAoRjJ3OE[5NlExRC:jPh?=
CD4+ T NE\DOnFHfW6ldHnvckBCe3OjeR?= MYCwMlAyNTFizszN NXvyclN{PDhiaB?= NFnxUmhFVVOR NWrBZ3N{emWmdXPld{B1cGVicHjvd5Bpd3K7bHH0bY9vKGyndnXsd{Bw\iCMQVuyJIFv\CCVVFHUN:Kh MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTV5MkWzOUc,OjV3N{K1N|U9N2F-
Caco-2  MYXGeY5kfGmxbjDBd5NigQ>? MVewMVEzOCEQvF2= NV;Fe3AzPyCvaX6= M1;tb4lvcGmkaYTzJJRpcWGvaX7lJJVxfGGtZTD3bZRpKGGwIFnDOVDDqG:oIEKuNeKhyrWP MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTB4M{[3Nkc,OjVyNkO2O|I9N2F-
Caco-2  NV7TbpBNTnWwY4Tpc44hSXO|YYm= NYDoPI5EOTBxNUCvNVAxKM7:TR?= MofRNkBp NYfsOmdX\GWlcnXhd4V{KHSqZTDmcJV5KG:oIGuzTH11cGmjbXnu[UBi[3Kxc4OgeIhmKG2xbn;sZZlmeiC5aYToJGlEPTBib3[gOk42yqEQvF2= NXL4dop3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwOlM3PzJpPkK1NFY{Pjd{PD;hQi=>
HEK293 MSR  MnP5SpVv[3Srb36gRZN{[Xl? MXywMVExKM7:TR?= MknLO{BucW5? NXXwWW9ocW6qaXLpeJMhcFSKVGKyJJdqfGhiYX6gTWM2OMLib3[gNU4zyqEEtV2= NGm3XVY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUC2N|Y4Oid-MkWwOlM3PzJ:L3G+
MedB-1 NHvqWmhHfW6ldHnvckBCe3OjeR?= MlfzNU8zKM7:TR?= NV;TfHZ6OjRiaB?= Mni4[IVkemWjc3XzJHNVSVR4IIDoc5NxcG:{eXzheIlwdiClb37j[Y51emG2aX;uJIRmeGWwZHXueIx6 NHfzSos9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm3O|Y3QCd-MkS5O|c3Pjh:L3G+
U2940 NWfjXpg{TnWwY4Tpc44hSXO|YYm= M{nhdlEwOiEQvF2= M1jUe|I1KGh? M3f3SYRm[3KnYYPld{BUXEGWNjDwbI9{eGixconsZZRqd25iY3;uZ4VvfHKjdHnvckBl\XCnbnTlcpRtgQ>? MojZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7N{e2OlgoRjJ2OUe3OlY5RC:jPh?=
K1106 MUXGeY5kfGmxbjDBd5NigQ>? MlznNU8zKM7:TR?= Mn;FNlQhcA>? NH24XHNl\WO{ZXHz[ZMhW1SDVE[gdIhwe3Cqb4L5cIF1cW:wIHPvcoNmdnS{YYTpc44h\GWyZX7k[Y51dHl? MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl5N{[2PEc,OjR7N{e2Olg9N2F-
K562 NIXaWYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnsZmgxNTFizszN NYHZbWhxPzJiaB?= NHniZnlqdmirYnn0d{BMPTZ{IHPlcIwheHKxbHnm[ZJifGmxbjDheEBpcWeqIHPvcoNmdnS{YYTpc44> NIn2eY89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEe3OVMxQCd-MkS3O|U{ODh:L3G+
MDA-MB-468  MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXyzJOK2VQ>? M4r5elQ5KGh? MV\lcohidmOnZDDzbYJkdDZiaX7keYNm\CCub4PzJI9nKGOnbHygeoli[mmuaYT5xsA> MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ4MkixPEc,OjR4NkK4NVg9N2F-
MDA-MB-468 NVPub3N6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjxenNROC12IN88US=> MVO0PEBp NULqdHduemW|dXz0d{B{cWewaX\pZ4FvfCCub4PzJI9nKH[rYXLpcIl1gSClb33wZZJm\CC2bzDSTU1DWEliYXzvcoU> M{nOdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2Nk[yPFE5Lz5{NE[2NlgyQDxxYU6=
L428 NGjBSHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LwW|AuPSEQvF2= MYq0PEBp NXL6[JRGcW6qaXLpeJMh[2WubDDndo94fGhic3nncolncWOjboTsfS=> M1zRPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkGwPFI4Lz5{NE[xNFgzPzxxYU6=
KMH2 NULteoprT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXmwMVUh|ryP M1PsWlQ5KGh? NFTQNYhqdmirYnn0d{Bk\WyuIHfyc5d1cCC|aXfubYZq[2GwdHz5 MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZzMEiyO{c,OjR4MUC4Nlc9N2F-
L1236 NELG[oNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jZcVAuPSEQvF2= NEjxW5g1QCCq MorZbY5pcWKrdIOgZ4VtdCCpcn;3eIghe2mpbnnmbYNidnSueR?= NGLNSXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[xNFgzPyd-MkS2NVA5Ojd:L3G+
SUPHD1 M3;NUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLBNE02KM7:TR?= MXm0PEBp NWnkOGRjcW6qaXLpeJMh[2WubDDndo94fGhic3nncolncWOjboTsfS=> NX[4OZhlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2NVA5OjdpPkK0OlExQDJ5PD;hQi=>
HDLM2 M{\XNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXOyclRLOC13IN88US=> NWOySXFqPDhiaB?= NUDYSHdTcW6qaXLpeJMh[2WubDDndo94fGhic3nncolncWOjboTsfS=> MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZzMEiyO{c,OjR4MUC4Nlc9N2F-
K1106P M3nsS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWmwMVUh|ryP M3XOXVQ5KGh? NEXl[4RqdmirYnn0d{Bk\WyuIHfyc5d1cCC|aXfubYZq[2GwdHz5 MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZzMEiyO{c,OjR4MUC4Nlc9N2F-
L428 NGjUNlhCeG:ydH;zbZMhSXO|YYm= NWPpNnFROC9yLk[yOU8yNjJ3IN88US=> M2LNUFQ5KGh? M2TOXolv\HWlZYOgeIhmKGGyb4D0c5Nqe8Li M2TpS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkGwPFI4Lz5{NE[xNFgzPzxxYU6=
KMH2 NVrVW3BjSXCxcITvd4l{KEG|c3H5 M2W4TVAwOC54MkWvNU4zPSEQvF2= MlPuOFghcA>? MmT0bY5lfWOnczD0bIUh[XCxcITvd4l{yqB? NXvLV2NCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2NVA5OjdpPkK0OlExQDJ5PD;hQi=>
L1236 MX3BdI9xfG:|aYOgRZN{[Xl? MoXGNE8xNjZ{NT:xMlI2KM7:TR?= MkTUOFghcA>? NHTj[WhqdmS3Y3XzJJRp\SCjcH;weI9{cXQEoB?= MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZzMEiyO{c,OjR4MUC4Nlc9N2F-
SUPHD1 M{DnTGFxd3C2b4Ppd{BCe3OjeR?= MUOwM|AvPjJ3L{GuNlUh|ryP NHfFNnQ1QCCq MYXpcoR2[2W|IITo[UBieG:ydH;zbZPDqA>? MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZzMEiyO{c,OjR4MUC4Nlc9N2F-
HDLM2 NImxXWxCeG:ydH;zbZMhSXO|YYm= NVzo[|BrOC9yLk[yOU8yNjJ3IN88US=> NIfHdGQ1QCCq M1S3RYlv\HWlZYOgeIhmKGGyb4D0c5Nqe8Li NHrITZI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[xNFgzPyd-MkS2NVA5Ojd:L3G+
K1106P NGLmXJhCeG:ydH;zbZMhSXO|YYm= M{fxNFAwOC54MkWvNU4zPSEQvF2= M1jtTVQ5KGh? MmCzbY5lfWOnczD0bIUh[XCxcITvd4l{yqB? MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZzMEiyO{c,OjR4MUC4Nlc9N2F-
L428 NVPWUHZuTnWwY4Tpc44hSXO|YYm= MkPXNE02KM7:TR?= NGDWepUzPCCq M2GzSYlvcGmkaYTzJGpCUzJxU2TBWEB{cWewYXzpcoc> M1LVSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkGwPFI4Lz5{NE[xNFgzPzxxYU6=
KMH2 MnvkSpVv[3Srb36gRZN{[Xl? MlvRNE02KM7:TR?= M{DSXFI1KGh? MoX5bY5pcWKrdIOgTmFMOi:VVFHUJJNq\26jbHnu[y=> NXvoVJlJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2NVA5OjdpPkK0OlExQDJ5PD;hQi=>
L1236 NYfOVYdbTnWwY4Tpc44hSXO|YYm= M1qzT|AuPSEQvF2= NHjDOIIzPCCq MlXDbY5pcWKrdIOgTmFMOi:VVFHUJJNq\26jbHnu[y=> NHrXb409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[xNFgzPyd-MkS2NVA5Ojd:L3G+
SUPHD1 NUW4flVDTnWwY4Tpc44hSXO|YYm= M3PsTVAuPSEQvF2= NXO2d4xxOjRiaB?= M2HKTIlvcGmkaYTzJGpCUzJxU2TBWEB{cWewYXzpcoc> NIDmdo49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[xNFgzPyd-MkS2NVA5Ojd:L3G+
HDLM2 NF;XTZVHfW6ldHnvckBCe3OjeR?= NXryTVB3OC13IN88US=> NXLENm5vOjRiaB?= M1mxdolvcGmkaYTzJGpCUzJxU2TBWEB{cWewYXzpcoc> NVu0dHJ{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2NVA5OjdpPkK0OlExQDJ5PD;hQi=>
K1106P M3e2fmZ2dmO2aX;uJGF{e2G7 MYWwMVUh|ryP MnHkNlQhcA>? M2rh[YlvcGmkaYTzJGpCUzJxU2TBWEB{cWewYXzpcoc> MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZzMEiyO{c,OjR4MUC4Nlc9N2F-
MM.1S  MnXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYW0UG5pUUN3ME2xMVMh|ryP NXXyZWl6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFQyODFpPkK0OVg1OTBzPD;hQi=>
TpoR JAK2 WT MkjoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3pTWM2OD1zLkSgLFEvO+LCk{GuOUkh|ryP NVXHfYZrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyOVE4QTBpPkK0NlUyPzlyPD;hQi=>
TpoR JAK2 V617F NInmbnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwODCoNE446oDVMD65LUDPxE1? M2rrclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MkWxO|kxLz5{NEK1NVc6ODxxYU6=
TpoR W515L MoriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\FT3NyUUN3ME2wMlghMDBwN,MAl|EvOClizszN NIrnNIM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEK1NVc6OCd-MkSyOVE4QTB:L3G+
Bcr-abl NX3nRnI{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17TT2lEPTB;Mj63JEgzNjMkgKOzMlMqKM7:TR?= MnzHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{NUG3PVAoRjJ2MkWxO|kxRC:jPh?=
JAK2 TW M{DNOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPUfpRKSzVyPUGuPEApOS534pETNk4{MSEQvF2= NH\STG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEK1NVc6OCd-MkSyOVE4QTB:L3G+
JAK2 V617F MnfmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTwTWM2OD1yLk[gLFAvPuLCk{CuO{kh|ryP MoLjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{NUG3PVAoRjJ2MkWxO|kxRC:jPh?=
MedB-1 MlLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjafmY1KM7:TR?= M2XTRlI1NzR6L{eyJIg> NYLQWIFzTE2VTx?= NITZRWpqdmirYnn0d{Bk\WyuIHfyc5d1cCC2aX3lJIRmeGWwZHXueIx6 M2HO[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OEWyN|Y3Lz5{M{i1NlM3PjxxYU6=
K1106 NILPTWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYW0JO69VQ>? MVSyOE81QC95MjDo M1\KS2ROW09? MWfpcohq[mm2czDj[YxtKGe{b4f0bEB1cW2nIHTldIVv\GWwdHz5 M2DsWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OEWyN|Y3Lz5{M{i1NlM3PjxxYU6=
U2940 M132WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW[xeGJIPCEQvF2= MW[yOE81QC95MjDo NILCbVFFVVOR MXzpcohq[mm2czDj[YxtKGe{b4f0bEB1cW2nIHTldIVv\GWwdHz5 MkXvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6NUKzOlYoRjJ|OEWyN|Y3RC:jPh?=
FE-PD MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDXdosxOC5yNkOtOEDPxE1? NHfHbWxKSzVyPUmuOUDPxE1uIHnubIljcXS|IHPlcIwh\3Kxd4ToJIRwe2ViZHXw[Y5l\W62bIm= MljuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|N{K2OlkoRjJ|M{eyOlY6RC:jPh?=
HEL NFr2eZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE[zRVcxNjB4Mz20JO69VQ>? MljkTWM2OD1zLkWg{txONCCrbnjpZol1eyClZXzsJIdzd3e2aDDkc5NmKGSncHXu[IVvfGy7 NWHIZmZqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzO|I3PjlpPkKzN|czPjZ7PD;hQi=>
K-562 NFP5VZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M16yelAvODZ|LUSg{txO NE\TTFVKSzVyPUKuOUDPxE1uIHnubIljcXS|IHPlcIwh\3Kxd4ToJIRwe2ViZHXw[Y5l\W62bIm= MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzN5Mk[2PUc,OjN|N{K2Olk9N2F-
L-82 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NECyOWgxNjB4Mz20JO69VQ>? M1S0UGlEPTB;MD65PEDPxE1uIHnubIljcXS|IHPlcIwh\3Kxd4ToJIRwe2ViZHXw[Y5l\W62bIm= MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzN5Mk[2PUc,OjN|N{K2Olk9N2F-
MAC-1 MlnwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLHToUxNjB4Mz20JO69VQ>? M1XYT2lEPTB;MD61NkDPxE1uIHnubIljcXS|IHPlcIwh\3Kxd4ToJIRwe2ViZHXw[Y5l\W62bIm= MoP0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|N{K2OlkoRjJ|M{eyOlY6RC:jPh?=
MAC-2A NWXWOpg3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;ocY93OC5yNkOtOEDPxE1? MmfrTWM2OD1yLk[5JO69VSxiaX7obYJqfHNiY3XscEBoem:5dHig[I9{\SCmZYDlcoRmdnSueR?= NVWzSHpXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzO|I3PjlpPkKzN|czPjZ7PD;hQi=>
MAC-2B M1HPNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTXfYFIOC5yNkOtOEDPxE1? NIm2d4dKSzVyPUCuOVQh|ryPLDDpcohq[mm2czDj[YxtKGe{b4f0bEBld3OnIHTldIVv\GWwdHz5 MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzN5Mk[2PUc,OjN|N{K2Olk9N2F-
MY-LA NULvOII6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml33NE4xPjNvNDFOwG0> MWnJR|UxRTJwMTFOwG0tKGmwaHnibZR{KGOnbHyg[5Jwf3SqIHTvd4Uh\GWyZX7k[Y51dHl? M4q5TlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{eyOlY6Lz5{M{O3NlY3QTxxYU6=
NC-NC MnL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4iwNFAvODZ|LUSg{txO NYjKOnp2UUN3ME2xMlAh|ryPLDDpcohq[mm2czDj[YxtKGe{b4f0bEBld3OnIHTldIVv\GWwdHz5 M3jRb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{eyOlY6Lz5{M{O3NlY3QTxxYU6=
SE-AX MoHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHu2V4kxNjB4Mz20JO69VQ>? MoH3TWM2OD1zLkWg{txONCCrbnjpZol1eyClZXzsJIdzd3e2aDDkc5NmKGSncHXu[IVvfGy7 NE\wZno9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{O3NlY3QSd-MkOzO|I3Pjl:L3G+
SR-786 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1Hlb|AvODZ|LUSg{txO NV3tOZk6UUN3ME20MlYh|ryPLDDpcohq[mm2czDj[YxtKGe{b4f0bEBld3OnIHTldIVv\GWwdHz5 NX\MTYFRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzO|I3PjlpPkKzN|czPjZ7PD;hQi=>
M-MOK  NFv5fFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULBfm95OjViwsXNxsA> NWC0O|lrOjRxNEivO|IhcA>? NEfkWWZFVVOR M2L5OolvcGmkaYTzJINmdGxiZ4Lve5RpKHSrbXWg[IVx\W6mZX70cJk> NFu3XFg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUi1N|E2Pyd-MkG4OVMyPTd:L3G+
HEL NWTySmFbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTTTWM2OD1|MEWgcm0> NYW5fpBIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUizPVQ2PTRpPkG4N|k1PTV2PD;hQi=>
Ba/F3 JAK2V617F NH;yblVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWn3V|BwUUN3ME2yO|Ahdk1? MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDN7NEW1OEc,OTh|OUS1OVQ9N2F-
MV4-11 M4K1R2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 NHKyfWQ4OiCqcoO= MX3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2YND2xNUBk\WyuczDh[pRmeiB5MjDodpMh[nliY3XscJRqfGW{LXLseYUh[XO|YYmsJGVEPTBiPTCwMlA4QSEQvF2u NVjEVnpqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyPFAzPjFpPkK4NlgxOjZzPD;hQi=>
MM1S M2\GTGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NHvxeno4OiCqcoO= NH3RUIJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3NNXMh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IITyfZBidiCkbIXlJIV5[2y3c3nvckBie3OjeTygTWM2OCB;IEGg{txONg>? NGHzPGo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEK4NFI3OSd-MkiyPFAzPjF:L3G+
NB1643 Mmf0dWhVWyCjc4PhfS=> MmPodWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKE6EMU[0N{Bk\Wyucx?= M4KyWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SK-N-MC MoHNdWhVWyCjc4PhfS=> M3L4fZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCVSz3OMW1EKGOnbHzz Moi1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=

... Click to View More Cell Line Experimental Data
Assay
Methods Test Index PMID
Western blot
p-JAK2 / p-STAT1 / p-STAT3 / p-STAT6 / p-STAT5 / JAK2 ; 

PubMed: 24610827     


Western analysis of pJAK2 and the downstream pSTATs following treatment with vehicle or the indicated concentrations of fedratinib for 24 hours. Total JAK2 and GAPDH are similarly analyzed.

c-Myc / PIM1 ; 

PubMed: 24610827     


Western analysis of c-MYC and PIM1 protein levels in cHL and MLBCL cell lines treated with vehicle or fedratinib at the indicated concentration for 24 hours. Data are representative of three independent experiments.

24610827
Growth inhibition assay
Cell proliferation ; 

PubMed: 24610827     


Cellular proliferation of cHL cell lines (L428, KMH2, L1236, SUPHD1 and HDLM2) and the MLBCL cell line (K1106P), following treatment with vehicle or fedratinib at indicated concentration for 48 hours. For each cell line, the previously reported 9p24.1/JAK2 copy numbers (7) are indicated in parenthesis. At a given dose of the JAK2 inhibitor (1.25 μM), a Kruskal-Wallis test was performed to assess the association between the ranked values of inhibition and copy number gain (p = .009, cHL and MLBCL cell lines; p = .019, cHL cell lines).

24610827
体内研究

TG101348有治疗JAK2V617F相关的骨髓增生性疾病(MPD)的潜力。在TG101348处理的动物中血细胞比容和白细胞计数有统计学显著减少，以剂量依赖性减少/消除髓外造血，至少在某些情况下，表现为衰减性骨髓纤维化，具有替代终点，包括减少/消除的JAK2V617F疾病负担，抑制内源性红细胞集落的形成相关，在体内抑制JAK-STAT信号转导。有没有明显的毒性并对T细胞数量无影响。[1] TG101348（120 mg/kg）口服显著抑制体内光伏红系祖细胞分化。[2]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验：

[1]
- 合并

无细胞激酶活性测定:

TG101348 的IC 50值使用Invitrogen公司的223激酶试剂盒测定，其中包括JAK2和JAK2V617F，或者Carna Biosciences的所有Janus激酶家族成员试剂盒，包括JAK1和TYK2。ATP浓度设定为激酶的Km值。
细胞实验：

[1]
- 合并
  • Cell lines: EpoBa/F3 JAK2V617F, Ba/F3p210, HEL和K562细胞
  • Concentrations: 溶解在DMSO中至终浓度约10 μM
  • Incubation Time: 72小时
  • Method:

    约2×103细胞接种到微量滴定板的孔中，加入含指定浓度抑制剂的100μLRPMI-1640培养基。TG101348温育72小时，50 μL XTT染料加入到每个孔中并孵育4小时，在CO2培养箱中培养。有色甲臜产物用分光光度法在450nm处测定在650nm处校正。50％的抑制作用（IC50）的浓度用GraphPad Prism 4.0软件确定。所有的实验都重复3次，并且结果和未处理的细胞的生长做比较。EpoBa/F3 JAK2V617F，Ba/F3p210，HEL和K562细胞凋亡是用DMSO和TG101348浓度的增加诱导来确定。


    (Only for Reference)
动物实验：

[1]
- 合并
  • Animal Models: C57BL / 6小鼠静脉注射表达JAK2V617F的全骨髓
  • Dosages: 约120 mg/kg
  • Administration: 口服，每天两次
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 100 mg/mL (190.59 mM)
Water Insoluble
Ethanol Insoluble

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 524.68
化学式

C27H36N6O3S
CAS号 936091-26-8
储存条件 粉状
溶于溶剂
别名 SAR302503

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量 只
第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量：

总分子量：g/mol

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03983161 Recruiting Drug: Fedratinib Healthy Volunteers|Hepatic Impairment Celgene|Impact Biomedicines Inc. a wholly owned subsidiary of Celgene Corporation July 15 2019 Phase 1
NCT03983239 Completed Drug: Fedratinib|Drug: Rifampin|Drug: Efavirenz Healthy Volunteers Celgene|Impact Biomedicines Inc. a wholly owned subsidiary of Celgene Corporation June 21 2019 Phase 1
NCT02596347 Completed Procedure: Blood draw|Procedure: bronchoscopy Chronic Beryllium Disease (CBD)|Beryllium Sensitization (BeS) National Jewish Health April 2015 --
NCT01692366 Completed Drug: SAR302503 Myelofibrosis Sanofi November 2012 Phase 2
NCT01523171 Completed Drug: SAR302503 Hematopoietic Neoplasm Sanofi April 2012 Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

  • * 必填项
Selleck产品目录册

JAK Signaling Pathway Map

JAK Inhibitors with Unique Features

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  • Ruxolitinib (INCB018424)

    Ruxolitinib (INCB018424)是第一个应用于临床的，有效的，选择性JAK1/2抑制剂，在无细胞试验中IC50为3.3 nM/2.8 nM。作用于JAK1， JAK2与作用于JAK3相比，选择性高130多倍。Ruxolitinib 通过毒性线粒体自噬杀死肿瘤细胞。Ruxolitinib 可诱导自噬并增强细胞凋亡。

  • Tofacitinib (CP-690550) Citrate

    Tofacitinib (CP-690550) Citrate是一种新型JAK抑制剂，对JAK3，JAK2，JAK1的IC50分别为1 nM, 20 nM 和112 nM。Tofacitinib citrate 还具有抗感染的活性。

  • Tofacitinib (CP-690550)

    Tofacitinib (CP-690550,Tasocitinib)是一种新型JAK3抑制剂，在无细胞试验中IC50为1 nM，作用于JAK2和JAK1选择性低20到100倍。Tofacitinib 可在人类浆细胞样树突状细胞PDC中抑制抗凋亡的BCL-A1和BCL-XL并诱导PDC凋亡。

  • AZD1480

    AZD1480是一种新型，ATP竞争性的JAK2抑制剂，无细胞试验中IC50为0.26 nM，选择性作用于JAK3和Tyk2，对JAK1的作用较弱。Phase 1。

    Features:AZD1480为治疗多发性骨髓瘤的潜在新型治疗剂。

  • Momelotinib (CYT387)

    Momelotinib (CYT387, LM-1149 , CYT11387) 是一种ATP竞争性JAK1/JAK2抑制剂，IC50为11 nM/18 nM，比作用于JAK3选择性约高10倍左右。Momelotinib (CYT387) 可诱导凋亡和自噬。Phase 3。

    Features:CYT387是ATP竞争性小分子JAK1 和JAK2抑制剂。

  • WP1066

    WP1066 是一种新型JAK2和STAT3抑制剂，在HEL细胞中IC50分别为2.30 μM和2.43 μM；对JAK2，STAT3，STAT5和ERK1/2具有抑制活性，而对JAK1和JAK3没有作用。WP1066 可诱导凋亡。Phase 1。

    Features:WP1066像它的母体化合物一样能抑制JAK2的磷酸化作用，但与AG490不同WP1066还能减少JAK2的蛋白量。

  • Baricitinib (INCB028050)

    Baricitinib (LY3009104, INCB028050)是一种选择性JAK1和JAK2抑制剂，无细胞试验中IC50分别为5.9 nM和5.7 nM，比作用于JAK3和Tyk2选择性高70和10倍左右，对c-Met和Chk2没有抑制作用。Baricitinib被发现可以减少或干扰病毒进入目标细胞，并用于COVID-19的治疗研究中。Phase 3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID