Palbociclib (PD-0332991) HCl

Pfizer辉瑞授权 目录号:S1116

Palbociclib (PD-0332991) HCl Chemical Structure

Molecular Weight(MW): 483.99

Palbociclib (PD-0332991) HCl是一种高度选择性的CDK4/6抑制剂,无细胞试验中IC50分别为11 nM/16 nM。它对CDK1/2/5,EGFR,FGFR,PDGFR,InsR等没有抑制活性。Phase 3。

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RMB 902.49 现货
RMB 1406.17 现货
RMB 4670.26 现货
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客户使用该产品的9个实验数据:

  • PD-0332991 causes inhibition of proliferation of EAC cells in a dose-dependent manner. Western blots showing the phosphorylation status of pRB at Ser780 and Ser795 after incubation with 125 nmol/L PD-0332991 for 24 and 72 hours. Reduction in cyclin A expression and the expression of RB2 (p130) tumor suppressor 72 hours after PD-0332991 treatment are shown (bottom). Total pRB (RB1) and actin are loading controls and T293 cell lysate (293) is a positive control for total pRB and phospho-pRB (Ph-RB). E, anchorage-independent growth of the 3 cell lines in the presence or absence (Cnt) of 125 nmol/L PD-0332991 for 3 weeks.

    Clin Cancer Res 2011 17(13), 4513-22. Palbociclib (PD-0332991) HCl purchased from Selleck.

    b, c MelJuso cells were treated for 12–48 h with 1 µM Selumetinib or 5 µM Palbociclib and the cells were fixed, stained with propidium iodide and cell cycle distribution was determined by flow cytometry (b) and whole cell extracts were fractionated by SDS-PAGE, transferred onto PVDF membrane and immuno-blotted with the indicated antibodies (c). Data is from a single experiment representative of three separate experiments with similar results. The data in (b) are mean ± S.D. from a single experiment with three replicate dishes of cell per data point; similar results were obtained in two additional experiments

    Cell Mol Life Sci, 2016, 73(4):883-900. Palbociclib (PD-0332991) HCl purchased from Selleck.

  • (A) Percentage of DN3a cells in S-phase (as gated on DAPI profile) from control (Zfp36l1/2fl/fl) and Zfp36l1/2fl/fl; CD2Cre (DCKO) mice, after 1 d of treatment with vector or palbociclib (drug).

    J Immunol, 2016, 197(7):2673-85. Palbociclib (PD-0332991) HCl purchased from Selleck.

     

    Patient tumor cell sensitivity to combinatorial treatment with histone deacetylase (HDAC)/cyclin-dependent kinase (CDK) inhibitors in 3-D culture. The effect of each drug or drug combination was assessed by fluorescent dye to identify live (green) and dead cells (red). Cells from breast reduction patients were used as non-cancer control in the assay.

    Pharmacogenomics J 2013 13(1), 94-104. Palbociclib (PD-0332991) HCl purchased from Selleck.

  • The expression of respective proteins in CDK4/6-Rb-apoptosis pathway in cells was examined by Western blot after 3 days of palbociclib treatment.

    Biochim Biophys Acta, 2018, 1864(5 Pt A):1573-1582. Palbociclib (PD-0332991) HCl purchased from Selleck.

     

    Cdk4 is upregulated in ARMS and mMSCs transfected with PAX7-FKHR fusion gene (MP7F), and can be specifi cally inhibited. D: IF results showing overexpression of cdk4 in MP7F cells compared to parental mMSCs and reduced expression of cdk4 after treatment of MP7F cells with the cdk4 inhibitor, PD-0332991. E: IF results showing MyoD1 expression in parental mMSCs cells, and MP7F cells untreated and after treatment with the cdk4 inhibitor, PD-0332991.

    Clin Transl Oncol 2012 14(3), 197-206 . Palbociclib (PD-0332991) HCl purchased from Selleck.

  • WM3734 melanoma cells were treated by PD-0332991 for 36 hours; melanoma cells treated by Doxorubicin (DXR)  at 0.5 μM is included as a control.

     

     

    Dr. Gao Zhang of University of Pennsylvania. Palbociclib (PD-0332991) HCl purchased from Selleck.

    Serum-deprived T98G glioma cells are restimulated with serum(FBS) with or without 1 μΜ PD-0332991.

     

     

    Dr. Sabine Paternot and Dr Pierre Roger of IRIBHM, ULB, Brussels. Palbociclib (PD-0332991) HCl purchased from Selleck.

  • P16INK4A knockdown in INK4A/ARF-wt human glioma cell LN319 potentiates PDGF-Apromoted anchorage-dependent growth in vitro. Soft agar growth of Ink4a/Arf-deficient mAst and LN444 cells treated with PD0332991. (A) IB analysis. (B) Quantification of soft agar assays. β-actin was used as a loading control in all IB experiments. Data are presented as mean ± s.d. and representative of two independent experiments. **, P < 0.01; ***, P < 0.001

    Dr. Kun-Wei Liu from University of Pittsburgh. Palbociclib (PD-0332991) HCl purchased from Selleck.

产品安全说明书

CDK抑制剂选择性比较

生物活性

产品描述 Palbociclib (PD-0332991) HCl是一种高度选择性的CDK4/6抑制剂,无细胞试验中IC50分别为11 nM/16 nM。它对CDK1/2/5,EGFR,FGFR,PDGFR,InsR等没有抑制活性。Phase 3。
特性 PD-0332991作为有应用前景的工具测定CDK激酶是否具有明显的治疗价值。
靶点
CDK4/CyclinD3 [1]
(Cell-free assay)
CDK4/CyclinD1 [1]
(Cell-free assay)
CDK6/CyclinD2 [1]
(Cell-free assay)
9 nM 11 nM 15 nM
体外研究

PD 0332991 对其他蛋白激酶包括EGFR, FGFR, PGFR, IR等没有抑制效果。 PD 0332991作用于Cdk4时是非ATP竞争性抑制剂。PD 0332991抑制MDA-MB-435乳腺癌细胞,IC50为66 nM,是由于Rb 在Ser780的磷酸化作用下降。PD 0332991抑制胸苷合并到Rb阳性的人类乳腺癌,结肠癌 肺癌,及白血病的DNA中,IC50值为4 nM到0.17 μM。PD 0332991作用于Rb阴性细胞没有抑制效果。PD 0332991作用于MDA-MB-453乳腺癌细胞和结肠-205细胞使细胞积累在G1期。[1]PD 0332991也有效作用于骨髓瘤5T33MM细胞,使细胞对Bortezomib敏感。[2]PD 0332991抑制luminalER-阳性和HER2-增强的乳腺癌细胞系,包括MDA-MB-175 ZR-75-30 CAMA-1 MDA-MB-134 HCC-202 UACC-893 等等。在这些细胞系中,PD 0332991增强Tamoxifen和Trastuzumab 的活性。在MCF7抗Tamoxifen细胞中,PD 0332991也增强tamoxifen 的敏感性。[3] 最新研究显示PD 0332991可以抑制恶性横纹肌样肿瘤(MRT)细胞系包括MP-MRT-AN, KP-MRT-RY, G401, KP-MRT-NS,且MRT细胞系对PD 0332991敏感性和p16表达呈负相关。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MOLM13 NV7wZXNrU2mwYYPlJGF{e2G7 MViyOEBp M3jONWlvcGmkaYTpc44hd2ZiQ1TLOEBie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJHJjKHCqb4PwbI9zgWyjdHnvckB4cXSqIFnDOVAhd2ZiMD6wNFIh|ryP NFrpNFEzPDZ2MUGwNy=>
COLO205 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnOO|IhcA>? MYjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5Nme3OnZDDhd{BqdmOxcoDvdoF1cW:wIH;mJHs{UF22aIntbYRqdmViaX70c{BFVkFid3n0bEBKSzVyIH;mJFAvODN4IN88US=> NYXqfHFvOjR4NEGxNFM>
U937 M2jObWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX63S41bPzJiaB?= NYe5Z4RNSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|ZYPz[YQh[XNiaX7jc5Jxd3KjdHnvckBw\iCdM1jdeIh6dWmmaX7lJIlvfG9iRF7BJJdqfGhiSVO1NEBw\iByLkG0JO69VQ>? NE\HR|UzPDZ2MUGwNy=>
MOLM13 NVjFWJBCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1i1blczKGh? M1vuVmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTV;MUVE{KGOnbHzzJIhiemKxcnnu[{BHVFR|IFnUSEBufXSjboSgZZN{\XO|ZXSgZZMhcW6lb4Lwc5JifGmxbjDv[kBcO0ifdHj5cYllcW6nIHnueI8hTE6DIIfpeIghUUN3MDDv[kAxNjB7NjFOwG0> MUCyOFY1OTFyMx?=
MOLM13 NHLkXYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzlNYs4OiCq Mkj4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDzc5Ji\mWwaXKtdoV{cXO2YX70JIh2dWGwIF3PUG0yOyClZXzsd{Bie3Onc4Pl[EBieyCrbnPvdpBwemG2aX;uJI9nKFt|SG30bJlucWSrbnWgbY51dyCGTlGge4l1cCCLQ{WwJI9nKDBwMEm2JO69VQ>? NEX6UWUzPDZ2MUGwNy=>
MDA-MB-435 NXPzenA3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HFSlI1KGh? MnPZTWM2OD1yLkG2JO69VQ>? M1\Se|E2QDBzOEOx
K562 NVO3NIw3S3m2b4TvfIlkKEG|c3H5 NIXoT3E6PiCq MYPEUXNQ MYXJR|UxRTJizszN MViyOFQyPzV4Nh?=
DU145 NYfwZnd4S3m2b4TvfIlkKEG|c3H5 Mn3XPVYhcA>? NWWwbJpMTE2VTx?= MlixTWM2OD15LkWg{txO M1\v[lI1PDF5NU[2
MDA-MB-231 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIL2XmEyKM7:TR?= NWfYTnA1OjRiaB?= MmnhSG1UVw>? NG\BXnlE\WyuIHP5Z4xmKGG{cnXzeEBie3Onc4Pl[EBieyCjY3P1cZVt[XSrb36gZZQhTzFicHjhd4U> M3S2Z|I1PDF5NU[2
MCF7 M1v0NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTpPYNxOSEQvF2= M2P1RlI1KGh? M{W4O2ROW09? MkLTR4VtdCCleXPs[UBienKnc4SgZZN{\XO|ZXSgZZMh[WOldX31cIF1cW:wIHH0JGcyKHCqYYPl M1vaelI1PDF5NU[2
MCF7 M3PSdGtqdmG|ZTDBd5NigQ>? NEHxOo02KM7:TR?= M3v3[lI1KGh? NWDP[HlqTE2VTx?= NXnmbW9FUW6qaXLpeIlwdiCxZjDy[YNwdWKrbnHueEBETEt2L3P5Z4xqdkRzIHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZicnX0bY5w[myjc4TvcYEheGixc4Doc5J6dGG2aX;uJIF1KFOncke4NC=> NV[xSWhWOjR2MUe1OlY>
MDA-MB-231 MWfLbY5ie2ViQYPzZZk> M1;JV|Uh|ryP MX[yOEBp M{HxbmROW09? M4e3RWlvcGmkaYTpc44hd2ZicnXjc41jcW6jboSgR2RMPC:leXPsbY5FOSCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHKndHnuc4Jt[XO2b33hJJBpd3OyaH;yfYxifGmxbjDheEBU\XJ5OEC= NF3CdpozPDRzN{W2Oi=>
MDA-MB-231 MVHGeY5kfGmxbjDBd5NigQ>? NHLOWWQyNTFyIN88US=> NGL0N4UzPCCq M1fkSGROW09? M4rIcIRw\XNibn;0JIlv\HWlZTDhdI9xfG:|aYOgZZN{\XO|ZXSgZZMhWEGUUDDjcIVifmGpZR?= M4D3R|I1PDF5NU[2
MCF7 M3XkfmZ2dmO2aX;uJGF{e2G7 MkLNNU0yOCEQvF2= M2HueFI1KGh? NIrDOXZFVVOR NFrlPHBld2W|IH7veEBqdmS3Y3WgZZBweHSxc3nzJIF{e2W|c3XkJIF{KFCDUmCgZ4xm[X[jZ3W= NYn6OnU4OjR2MUe1OlY>
MDA-MB-231 NVjLdY1PTnWwY4Tpc44hSXO|YYm= NX3hPZUyOC53LUGg{txO NGL2PYo1QCCq M4L6cmROW09? Mkj2bIF{KG6xIFPlcIwh[3mlbHWgZZJz\XO2IHHzd4V{e2WmIHHzJIFk[3WvdXzheIlwdiCjdDDzeYIuTzFicHjhd4U> M3jpbVI1PDF5NU[2
MCF7 M{LPVWZ2dmO2aX;uJGF{e2G7 NFrpTZQxNjVvMTFOwG0> MWm0PEBp NXzn[|E1TE2VTx?= M2\N[4hieyCwbzDD[YxtKGO7Y3zlJIFzemW|dDDhd5Nme3OnZDDhd{Bi[2O3bYXsZZRqd25iYYSgd5VjNUdzIIDoZZNm NVP6fHlzOjR2MUe1OlY>
697 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrVeppKSzVyPUG0PE4{QCCwTR?= NETMO|lUSU6JRWK=
P12-ICHIKAWA MonsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTl4LkC0JI5O M2e0WXNCVkeHUh?=
NB69 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjr[HNKSzVyPUG2NU45KG6P NFPzWGpUSU6JRWK=
EoL-1 NVTH[FNzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XhWGlEPTB;MUi3MlI3KG6P NEG5cZlUSU6JRWK=
BHT-101 M2L5PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTF7OD6yOUBvVQ>? M1vINXNCVkeHUh?=
SK-NEP-1 M2TDVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTJ{MD6wNkBvVQ>? NWDENI86W0GQR1XS
MHH-NB-11 NX[3NGprT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;KWmRuUUN3ME2yNlAvOTlibl2= M3;CbHNCVkeHUh?=
AsPC-1 NILCS|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDVNHNKSzVyPUK1Nk42OyCwTR?= M33ycXNCVkeHUh?=
ES1 NYXEcXg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETUXVdKSzVyPUK1Ok4zPSCwTR?= M4TEXHNCVkeHUh?=
LAMA-84 M1rtTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTJ3OD6xPUBvVQ>? Moj3V2FPT0WU
MOLT-16 MmPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmX3TWM2OD1{NUiuOFkhdk1? MkXrV2FPT0WU
ES7 MoqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTJ5Mz6wPUBvVQ>? MWHTRW5ITVJ?
KY821 M1n0fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\ze4NKSzVyPUOxOE4yKG6P MXzTRW5ITVJ?
RT-112 Mo\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTN{MT6wOUBvVQ>? NFLLWpJUSU6JRWK=
HL-60 NFjoNHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XmWWlEPTB;M{SwMlY3KG6P MlPVV2FPT0WU
MOLT-4 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTN2NT6xN{BvVQ>? MVLTRW5ITVJ?
KARPAS-45 M1Tmd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3X1T2lEPTB;M{e2MlE3KG6P NXn1[XBqW0GQR1XS
SK-N-AS MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvXPXVKSzVyPUO4O{45OyCwTR?= MXTTRW5ITVJ?
CTB-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTRyNT6wNkBvVQ>? NFu5RpNUSU6JRWK=
NKM-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTRzMT64PUBvVQ>? NHTZbXBUSU6JRWK=
HTC-C3 M2jpXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTR|Mj65OUBvVQ>? NHHaW|FUSU6JRWK=
BE-13 NHrld2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTR2ND6yO{BvVQ>? MnmxV2FPT0WU
KOSC-2 NUXodGtjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\tRW1KSzVyPUS2Ok46KG6P MXnTRW5ITVJ?
NB14 NUHnOXpyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2THb2lEPTB;NEizMlU5KG6P M{\OZnNCVkeHUh?=
CAL-27 M3zGSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTR7ND61PUBvVQ>? M2O1V3NCVkeHUh?=
H9 Mn71S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGqyTG1KSzVyPUS5OU41OyCwTR?= NFTObFhUSU6JRWK=
RS4-11 M3m1UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTVyND63N{BvVQ>? NFj0UnhUSU6JRWK=
PA-1 MnHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTVyOT64OkBvVQ>? MYDTRW5ITVJ?
MV-4-11 MmO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjDXWhKSzVyPUWxN{45PSCwTR?= MmrLV2FPT0WU
OS-RC-2 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzoTWM2OD13MkGuOlIhdk1? MXHTRW5ITVJ?
RPMI-8226 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHjNlFKSzVyPUWyOk45PiCwTR?= MWPTRW5ITVJ?
HGC-27 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLRc4VKSzVyPUW2OE46QSCwTR?= MmDMV2FPT0WU
CHP-212 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLsT|FQUUN3ME21PVMvPTlibl2= NF;Ce2tUSU6JRWK=
NB10 M4\USGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF6zUYZKSzVyPUW5PU4yQCCwTR?= MVzTRW5ITVJ?
HH NHXNTGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3LTWM2OD13OUmuOFMhdk1? M4nKOnNCVkeHUh?=
EW-16 MmfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\oTWM2OD14MEOuOVIhdk1? NUX4NFRyW0GQR1XS
ES8 M3zMXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvwTWM2OD14MEWuNlEhdk1? MkH2V2FPT0WU
HAL-01 NFPJV4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnuW2tqUUN3ME22NFUvPjdibl2= NXjmV5RIW0GQR1XS
A204 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnniTWM2OD14M{OuPVEhdk1? MVHTRW5ITVJ?
MHH-PREB-1 NX;ucWRbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zCVGlEPTB;NkO2Mlk6KG6P MojJV2FPT0WU
EM-2 MmrHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\udWRFUUN3ME22OVAvPjRibl2= Ml3jV2FPT0WU
BV-173 NYPSdIg5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPpTWM2OD14NUKuOFghdk1? M2LyOXNCVkeHUh?=
ONS-76 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37PWWlEPTB;Nke3MlgzKG6P M3f6dXNCVkeHUh?=
KM-H2 MnjnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTlTFE6UUN3ME22PVUvPTRibl2= MomxV2FPT0WU
D-263MG MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\Y[mlEPTB;N{G3MlEzKG6P MkXhV2FPT0WU
ES3 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\Me3p{UUN3ME23NlgvQTNibl2= M3\PcnNCVkeHUh?=
VA-ES-BJ MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYn0dXNGUUN3ME23N|IvOjdibl2= NXPSOnE1W0GQR1XS
NBsusSR NH\0W45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHONGNTUUN3ME23OFIvQTlibl2= NXT2bWdKW0GQR1XS
NCI-H520 NE\xT5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYq1eItTUUN3ME23OFYvPTJibl2= M3XVbnNCVkeHUh?=
ES5 M{nUVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTd3Mj64JI5O MWDTRW5ITVJ?
T-24 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3WyZ2lEPTB;N{e4MlcyKG6P MnvMV2FPT0WU
SW962 NHPzUHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;GTWM2OD16MEiuOlMhdk1? Ml;mV2FPT0WU
EW-3 M2jEbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{POUmlEPTB;OEC4Mlc3KG6P NVHDV|dSW0GQR1XS
RXF393 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zBVWlEPTB;OEGyMlc6KG6P MoL2V2FPT0WU
U251 NICyNmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M173cmlEPTB;OEGzMlg5KG6P MoTQV2FPT0WU
CAMA-1 M3\4VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrmUYxKSzVyPUizN{46PCCwTR?= NXrk[ZJsW0GQR1XS
JVM-3 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXlTWM2OD16NUGuO|ghdk1? MUXTRW5ITVJ?
COLO-800 NY\RXZNnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmroTWM2OD16OUeuO|ghdk1? NXnuPGNxW0GQR1XS
OVCAR-5 MlfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHYSnhKSzVyPUmwNE4yKG6P NGfoVWZUSU6JRWK=
LB1047-RCC NGDXUJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVy3dpk6UUN3ME25NlcvPTZibl2= MWLTRW5ITVJ?
SW954 Mm\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLPUmhKSzVyPUmyPU41OSCwTR?= M2\MSHNCVkeHUh?=
J-RT3-T3-5 NWHXN5MyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnYS5FKSzVyPUmzOk4xPiCwTR?= MW\TRW5ITVJ?
Mewo NH7TTVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXHTWM2OD17M{[uOkBvVQ>? M3O3NXNCVkeHUh?=
NCI-H1770 MnHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTl2MD61OUBvVQ>? MlTsV2FPT0WU
HO-1-N-1 NVXOOolzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrCTWM2OD17NkKuPFEhdk1? NIHnflNUSU6JRWK=
HSC-3 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPmTFNKSzVyPUm2Ok41QCCwTR?= M4\aRnNCVkeHUh?=
TYK-nu M1LvV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTl7OD6yOUBvVQ>? NUXQUHZPW0GQR1XS
KYSE-150 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnETWM2OD1zLkCwNFc3KM7:TR?= NHzUNGxUSU6JRWK=
SN12C M2nJNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF64WJRKSzVyPUGuNFA5PzVizszN NG[xXWpUSU6JRWK=
MOLT-13 NWjKRVc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TDT2lEPTB;MT6wNVQzOSEQvF2= MVrTRW5ITVJ?
TE-11 M4nwWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37EZmlEPTB;MT6wOFgyOiEQvF2= NF\KSGlUSU6JRWK=
DB M1rhRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnvPWtSUUN3ME2xMlA4Ojd|IN88US=> NYTIPI93W0GQR1XS
CAL-39 NH;EZnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnZZXBKSzVyPUGuNFc2OjJizszN NYWwT|E4W0GQR1XS
A3-KAW M1\qWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3H2ZmlEPTB;MT6wPFQxQCEQvF2= NFvHfHBUSU6JRWK=
CHP-134 NFHqPZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTFwMUG4NFch|ryP MXLTRW5ITVJ?
TGW MmqxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\lcJZKSzVyPUGuNVI{QTVizszN MmrPV2FPT0WU
QIMR-WIL M1\P[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXrRYRKSzVyPUGuNVMyOzRizszN NEnWUJFUSU6JRWK=
NCI-SNU-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTFwMU[zOVQh|ryP NHj2N5RUSU6JRWK=
CGTH-W-1 NGXBNVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkn4TWM2OD1zLkG3NVg3KM7:TR?= M3:3RXNCVkeHUh?=
MHH-ES-1 MmDnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTFwMUe5PFYh|ryP MYnTRW5ITVJ?
LB2241-RCC MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PMNmlEPTB;MT6xPFYzKM7:TR?= MVfTRW5ITVJ?
ML-2 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYCxR5poUUN3ME2xMlIxPzN2IN88US=> MWrTRW5ITVJ?
COR-L23 NXq1fmlwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XkXGlEPTB;MT6yNlk{OyEQvF2= MWnTRW5ITVJ?
BFTC-905 M171fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTFwMkSyOlch|ryP MVfTRW5ITVJ?
Hs-578-T M2XaOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHBcY9WUUN3ME2xMlI2QDF5IN88US=> NVPSOpBnW0GQR1XS
KG-1 MoTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVq5cpdoUUN3ME2xMlI3Pjh4IN88US=> Mn\PV2FPT0WU
HEL M4\uemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTFwMkmzN|gh|ryP MoXvV2FPT0WU
A549 MoPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7wTWM2OD1zLkK5N|k6KM7:TR?= NHS4eWFUSU6JRWK=
COLO-741 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPXTWM2OD1zLkOyNFg6KM7:TR?= M4PrZ3NCVkeHUh?=
PC-3 MnvUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGCybmJKSzVyPUGuN|UzOjFizszN NUe1eGFqW0GQR1XS
HOS MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2j6T2lEPTB;MT6zOVI6PiEQvF2= M1S1UHNCVkeHUh?=
HT-1080 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4n2SGlEPTB;MT6zO|UyQSEQvF2= NGDvZVJUSU6JRWK=
TE-8 NXvWUZppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\OeodKSzVyPUGuOFE4PzRizszN NILSW|VUSU6JRWK=
BHY MkXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3zR2FiUUN3ME2xMlQ3QTJ|IN88US=> MkfQV2FPT0WU
BB65-RCC NWfHO5hxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXvfW9OUUN3ME2xMlUxPTJ6IN88US=> MUnTRW5ITVJ?
HN Mnz4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\YVlVyUUN3ME2xMlU1ODdzIN88US=> Mn\hV2FPT0WU
NCI-H441 M1XZUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTrN5pyUUN3ME2xMlU1QTB5IN88US=> MU\TRW5ITVJ?
RPMI-8866 NEL0[VFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjwcplKSzVyPUGuOVg2ODdizszN M1HHWnNCVkeHUh?=
CAL-62 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHiy[G5KSzVyPUGuOlA5PjJizszN NFznUJhUSU6JRWK=
MG-63 NHvyZYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEOwSG5KSzVyPUGuOlE5OTNizszN Ml2xV2FPT0WU
SK-LU-1 M1zDO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTFwNkKxOVIh|ryP MXjTRW5ITVJ?
BCPAP NVrOV3F2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTFwNk[0OVch|ryP M2DYT3NCVkeHUh?=
22RV1 MnvRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HudGlEPTB;MT62O|g1OyEQvF2= MoL6V2FPT0WU
T47D NEfkZ|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTFwNkiwOlEh|ryP M1\0Z3NCVkeHUh?=
MSTO-211H M4fKbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTFwNkm2NFMh|ryP MXHTRW5ITVJ?
DEL M1TNUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFe1TI9KSzVyPUGuO|AzPzNizszN MXzTRW5ITVJ?
H4 NW\tVGRYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPkWphKSzVyPUGuO|MzOTJizszN NWTsbYFMW0GQR1XS
CAL-51 NV[y[WNUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFOxRWVKSzVyPUGuO|Q5PTVizszN MXTTRW5ITVJ?
ABC-1 NIr2RpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLBZ3dKSzVyPUGuO|g2QDJizszN MV\TRW5ITVJ?
MZ2-MEL M1PU[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnoUoVKSzVyPUGuO|k2PDJizszN Mo\xV2FPT0WU
YKG-1 NEHvSYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvUTWM2OD1zLkixNFYyKM7:TR?= MmPRV2FPT0WU
KM12 MlS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfjWnVKSzVyPUGuPFE3ODJizszN MkC4V2FPT0WU
L-363 MlTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLZTWM2OD1zLki3OFEzKM7:TR?= MlzvV2FPT0WU
KU812 NUXTXWlpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTFwOEmyPFIh|ryP MnrqV2FPT0WU
LOXIMVI NILIc4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moj5TWM2OD1zLkmxNlI5KM7:TR?= M2H4cXNCVkeHUh?=
G-401 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nrPGlEPTB;MT65NlQzQCEQvF2= NWfuTHBCW0GQR1XS
SW780 NVv0TWdTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7pNlVKSzVyPUGuPVYzPDZizszN M1m2dHNCVkeHUh?=
SW872 NVS0fWF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLuTWM2OD1zLkm4N|Mh|ryP M4HmXHNCVkeHUh?=
NB7 NW\m[Gw5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTFwOUmzNlMh|ryP MmXuV2FPT0WU
T98G NGTMOopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;LV|RiUUN3ME2yMlAxPjZ4IN88US=> M1z5NnNCVkeHUh?=
SW1710 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTHZYs{UUN3ME2yMlA3QTR3IN88US=> MV\TRW5ITVJ?
NCI-H1573 M1HrR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1THW2lEPTB;Mj6wO|I6QCEQvF2= NI\Qe3RUSU6JRWK=
KE-37 NWXFWpdGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17J[WlEPTB;Mj6wPFk2OSEQvF2= MVPTRW5ITVJ?
786-0 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPzfpZDUUN3ME2yMlE2PDN7IN88US=> MknEV2FPT0WU
SAS M2j1Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTJwMkCzO|Qh|ryP MVPTRW5ITVJ?
CAL-54 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TxOWlEPTB;Mj6yNFQyOyEQvF2= MlTFV2FPT0WU
SF268 NXnPb5hYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrQTWM2OD1{LkKzNVIzKM7:TR?= NGjjXYFUSU6JRWK=
SW620 NUiyb5BwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnu5TWM2OD1{LkK2NVY6KM7:TR?= NWXzRW5IW0GQR1XS
MN-60 NHjuO5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfaNGNKSzVyPUKuN|ExPiEQvF2= NYTxT2ZxW0GQR1XS
EFO-27 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjaVpVKSzVyPUKuN|IxPThizszN MWPTRW5ITVJ?
NCI-H747 NWj2RYJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PE[2lEPTB;Mj6zNlE6QSEQvF2= MX;TRW5ITVJ?
HCC2218 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XxWWlEPTB;Mj6zOVM4PCEQvF2= M1;xWHNCVkeHUh?=
MIA-PaCa-2 NWLDXlBOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HX[WlEPTB;Mj6zOlQ{PyEQvF2= NUPFO5RvW0GQR1XS
SJSA-1 NFrtVJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\yXop2UUN3ME2yMlM4Pzl4IN88US=> MkP6V2FPT0WU
RKO NX\IXYZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfQem1KSzVyPUKuN|g1QTZizszN MknSV2FPT0WU
NB6 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvGZW9KSzVyPUKuOFA{PzRizszN MkXmV2FPT0WU
ES4 NESySIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTJwNEW0NlIh|ryP NIHIOW1USU6JRWK=
EGI-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPTTWM2OD1{LkS2PFg{KM7:TR?= M3nIWHNCVkeHUh?=
CTV-1 NWnPUGR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3ETWM2OD1{LkWyO|c{KM7:TR?= M{XPN3NCVkeHUh?=
NCI-H1355 Ml25S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TaNmlEPTB;Mj61OVk2OSEQvF2= MkfEV2FPT0WU
GT3TKB NVjmeHlUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTJwNUmxPVkh|ryP NIDuPFJUSU6JRWK=
SK-HEP-1 NE\NPJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljITWM2OD1{LkW5NlY3KM7:TR?= M1nMfXNCVkeHUh?=
GAMG NEHaTGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTJwNUmzPVQh|ryP M3\lNnNCVkeHUh?=
SK-MES-1 NILiT3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEL0[m1KSzVyPUKuOlE5ODNizszN M3n2U3NCVkeHUh?=
RO82-W-1 M2HvTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rNUGlEPTB;Mj62NlA2PyEQvF2= M17pT3NCVkeHUh?=
ECC10 NWW5fZdbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjqe2ZKSzVyPUKuO|AzODZizszN MWjTRW5ITVJ?
MCF7 NX;HXYptT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\GVWhKSzVyPUKuO|E1PjRizszN MlfzV2FPT0WU
D-283MED NX;5dmt5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDCeYxKSzVyPUKuO|I1OyEQvF2= MXzTRW5ITVJ?
RPMI-7951 M3yxZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;pbWRLUUN3ME2yMlc2Pjl2IN88US=> M3XqXHNCVkeHUh?=
Ramos-2G6-4C10 NF:2c41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPhdYZKSzVyPUKuO|cxQTlizszN MmixV2FPT0WU
KGN M4T5emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fRNWlEPTB;Mj64NVg5PCEQvF2= MXfTRW5ITVJ?
NUGC-3 NUWxWW16T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4SzeWlEPTB;Mj64NlUxPSEQvF2= NH:zW5lUSU6JRWK=
NCI-H292 NEjVUXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTJwOEWwOVMh|ryP MV;TRW5ITVJ?
Becker NXHMTVF7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUX6fmp{UUN3ME2yMlk2QDN{IN88US=> MUnTRW5ITVJ?
NCI-H1299 NFTzfVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknITWM2OD1|LkC1NlY{KM7:TR?= NWTaW2RVW0GQR1XS
ETK-1 Ml\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTNwMEW0N{DPxE1? NVvmeGVnW0GQR1XS
TK10 MlXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmC1TWM2OD1|LkKwNVY2KM7:TR?= MlXIV2FPT0WU
VMRC-RCZ NX;rO2dqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPQOpBKSzVyPUOuN|Y1QDhizszN NWTnSllqW0GQR1XS
YH-13 NYjjZYxYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPYZ|ZKSzVyPUOuOFQxPzlizszN NEjNNGdUSU6JRWK=
DU-145 M2\0[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjVTWM2OD1|LkS2NlY6KM7:TR?= NFHLd2ZUSU6JRWK=
SW1088 MlvDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTNwNEe0O{DPxE1? MYDTRW5ITVJ?
HOP-92 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7TVmpKSzVyPUOuOVA{PDJizszN MYLTRW5ITVJ?
KP-N-YS NXfZXY1[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfQTWM2OD1|Lk[yNVM6KM7:TR?= M3PoOXNCVkeHUh?=
NCI-H460 NXHZ[HptT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTNwNk[3N{DPxE1? NVvhOItYW0GQR1XS
U-2-OS M2G5fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fIN2lEPTB;Mz63NlU{PSEQvF2= Mk\3V2FPT0WU
A101D M{PZZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTNwN{[5N|Yh|ryP MX3TRW5ITVJ?
MDA-MB-231 Mlr5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTNwOEG5OVEh|ryP MnnwV2FPT0WU
IST-MES1 NGHiR4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LRUWlEPTB;Mz64N|Ih|ryP MmPkV2FPT0WU
COR-L105 NI\hOYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfDU3BKSzVyPUSuNFE5KM7:TR?= M4DSZ3NCVkeHUh?=
NCI-H1437 M1rFXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjzTWM2OD12LkCyN|AzKM7:TR?= M1TuPHNCVkeHUh?=
CAL-85-1 NIT4dXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk[5TWM2OD12LkCyOFYyKM7:TR?= MX7TRW5ITVJ?
MZ1-PC M1zXVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPXWopKSzVyPUSuNVg2PTZizszN MVzTRW5ITVJ?
VM-CUB-1 NW\CcJQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTRwM{GyPFQh|ryP NEjzfIpUSU6JRWK=
CHL-1 M1nMR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnGTWM2OD12LkOyNVY6KM7:TR?= NUXkWWVsW0GQR1XS
MDA-MB-361 NUH6ZWU1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHqxNlFKSzVyPUSuN|MyPTNizszN MlzoV2FPT0WU
NCI-H661 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzJdG5KSzVyPUSuOVAxQTJizszN MmnqV2FPT0WU
EW-11 Mmm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HFXmlEPTB;ND61NlI{OSEQvF2= NVLX[W9GW0GQR1XS
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C32 MnTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NImxflBKSzVyPUG5MlA1PSEQvF2= MWjTRW5ITVJ?
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LB996-RCC M{fOSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjwTWM2OD1{MD63NVY5KM7:TR?= M1r6TXNCVkeHUh?=
KYSE-70 NGfXb3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrON3E5UUN3ME2yNE45ODV7IN88US=> MWrTRW5ITVJ?
CAL-72 MlnqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4WzcWlEPTB;MkCuPVE2KM7:TR?= NVLaR3JjW0GQR1XS
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SBC-1 MoLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrvTWM2OD1{MT6zNFgyKM7:TR?= MV;TRW5ITVJ?
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SJRH30 NHjJOWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTJ3Lk[0PVYh|ryP NELCXmVUSU6JRWK=
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GP5d M33u[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTBdnBXUUN3ME2yOk41PDlzIN88US=> NIPyVmxUSU6JRWK=
NCI-H2291 M1zlOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4G3R2lEPTB;Mk[uOlU1OSEQvF2= MULTRW5ITVJ?
BALL-1 M1j0TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzyRo5LUUN3ME2yOk46Ozl5IN88US=> NUXaVG04W0GQR1XS
HCC1954 NIfmbVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjJTGtKSzVyPUK2Mlk5ODhizszN MWLTRW5ITVJ?
NCI-H2452 MmPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTJ5LkSxOlMh|ryP MluzV2FPT0WU
LU-99A M3Xnc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTJ5LkW1PFIh|ryP MoPXV2FPT0WU
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PANC-10-05 NFKxbIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLESXI{UUN3ME2yO{44Pzd3IN88US=> MWDTRW5ITVJ?
NCI-H2405 M{HV[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvZRnhKSzVyPUK3Mlk{QDdizszN MnHjV2FPT0WU
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NCI-H2342 NHnrNlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTJ6LkWyPFEh|ryP MVnTRW5ITVJ?
TGBC24TKB NEDES3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Dl[2lEPTB;MkiuO|EyPyEQvF2= M4fW[XNCVkeHUh?=
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Saos-2 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTNzLkmzNFYh|ryP MV7TRW5ITVJ?
RERF-LC-MS MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fwWWlEPTB;M{KuPFI{OSEQvF2= M4DYeXNCVkeHUh?=
M14 M3fVXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTN{Lkm3OlQh|ryP MojMV2FPT0WU
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NCI-H1755 NVHMUWE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTN2LkOzNFUh|ryP MoX6V2FPT0WU
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A704 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\JRZdKSzVyPUO2MlA1OjdizszN NUTDdG1SW0GQR1XS
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EW-18 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmO2TWM2OD1|Nj60OVIh|ryP NEG3WI9USU6JRWK=
WM-115 MoXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHWcWhTUUN3ME2zOk45ODl7IN88US=> M1XGT3NCVkeHUh?=
LU-65 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHHXIg5UUN3ME2zO{4yPDF5IN88US=> NUjtcm5FW0GQR1XS
NCI-H1563 M4jW[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTN5LkK0PFQh|ryP M2PTd3NCVkeHUh?=
DBTRG-05MG MljCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jxNGlEPTB;M{iuNFY6OSEQvF2= NX71RXd2W0GQR1XS
NCI-H630 NFPvZYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvaTWM2OD1|OD60O|E1KM7:TR?= MUjTRW5ITVJ?
NCI-H1155 Mn\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7RfmJKSzVyPUO5MlI1OiEQvF2= M3\pRnNCVkeHUh?=
OVACR-3 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDsRotKSzVyPUO5MlkyQTVizszN M{PCfXNCVkeHUh?=
OAW-42 NUPne2llT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LsU2lEPTB;NECuOFI2QCEQvF2= MWfTRW5ITVJ?
JVM-2 NVy5bGJjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;oSWxKSzVyPUSxMlI1OTVizszN NIfnTGpUSU6JRWK=
C3A NGGzXFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnuTWM2OD12MT6zOFQ4KM7:TR?= Ml\PV2FPT0WU
HT55 MmrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXGTWM2OD12Mj6yPFQyKM7:TR?= MnHQV2FPT0WU
OVCAR-4 M4e1eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTR{LkK5O|Qh|ryP NETLe4dUSU6JRWK=
MEG-01 NWDzWmhmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnw[phKSzVyPUSyMlQ3OTZizszN MVfTRW5ITVJ?
NCI-H82 MnO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTR|Lkm4PVIh|ryP NHP6d5FUSU6JRWK=
JEG-3 MnXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYroS3FnUUN3ME20OE46PDdizszN MV\TRW5ITVJ?
BPH-1 NULXVoQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTR4LkO5PVgh|ryP M3rVO3NCVkeHUh?=
MPP-89 M1m0XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzVXmFDUUN3ME20O{4zQDl6IN88US=> MWfTRW5ITVJ?
ALL-PO Mn60S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorFTWM2OD12Nz60NVg5KM7:TR?= M{nYeHNCVkeHUh?=
HT MlfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\yTWM2OD12Nz60PVIh|ryP Mke0V2FPT0WU
NCI-H2347 M13jXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF2w[YRKSzVyPUS4MlA4OTVizszN M13yPXNCVkeHUh?=
A2780 MnzPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXuNXNEUUN3ME20PU41OjJ6IN88US=> M4rp[3NCVkeHUh?=
KARPAS-299 M1\GZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLMTWM2OD12OT61NVE6KM7:TR?= MYDTRW5ITVJ?
NCI-H1651 NF\DN3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfvO49KSzVyPUS5Mlg5OjFizszN NWXMZXg3W0GQR1XS

... Click to View More Cell Line Experimental Data

体内研究 150 mg/kg PD 0332991处理 MDA-MB-435移植瘤完全抑制肿瘤。在多种人类肿瘤移植瘤中,PD 0332991也显示广谱抗癌活性,通过除去血管中p-Rb和增殖Marker Ki-67,且调节基因使其处于E2F转录水平控制。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

+ 展开

Cdk实验:

PD0332991溶解在DMSO中。在96孔板上进行CDK 实验。通过杆状病毒感染,所有的CDK-cyclin 激酶复合体 在昆虫细胞中表达。实验底物为与GST融合的一段pRb。每孔体积为0.1 ml,包含:终浓度为20 mm Tris-HCl(pH 为7.4), 50 mmNaCl, 1 mm二硫苏糖醇, 10 mmMgCl2, 25 μm ATP (用于CDK4-cyclin D1, CDK6-cyclin D2,和CDK6-cyclin D3)或12 μm ATP (用于CDK2-cyclin E, CDK2-cyclin A, 和CDC2-cyclin B),0.25 μCi [γ-32P]ATP, 20 ng 酶, 1 μg GST·RB-Cterm, 及PD 0332991 (0.001-0.1μM)。除了[γ-32P]ATP的所有混合物加到孔中,放在搅拌器上搅拌2分钟。加入 [γ-32P]ATP开始反应, 在25 oC下温育15分钟。加入0.1 ml 20% 三氯乙酸终止反应, 在4 oC维持至少1小时,使底物沉淀。用0.2 ml 10%三氯乙酸冲洗5次,用β-计数器板测定掺入的放射性。
细胞实验:

[1]

+ 展开
  • Cell lines: MDA-MB-435, ZR-75-1, T-47D, MCF-7, H1299, Colo-205, MDA-MB-468, H2009, CRRF-CEM,和K562细胞
  • Concentrations: 0.01-1 μM
  • Incubation Time: 24小时
  • Method:

    肿瘤细胞包括MDA-MB-435, ZR-75-1, T-47D, MCF-7, H1299, Colo-205, MDA-MB-468, H2009, CRRF-CEM,及K562按每孔2×104个细胞接种在96孔板上,温育过夜。加入PD 0332991 (0.01-1 μM) ,37oC温育24小时。每孔加入[14C]胸甘(0.1 μCi) ,进行同位素示踪,持续72小时。用β-计数器板测定掺入的放射性。


    (Only for Reference)
动物实验:

[1]

+ 展开
  • Animal Models: 携带晚期人类肿瘤移植瘤,包括结肠-205, MDA-MB-435 乳腺癌, SF-295 恶性胶质瘤, ZR-75-1 乳腺癌, PC-3 前列腺癌, H125 肺癌, SW-620结肠癌, H23肺癌,及MDA-MB-468 乳腺癌 (Rb 阴性)的SCID鼠
  • Formulation: 溶解在乳酸钠buffer(50 mM, pH 4.0)中
  • Dosages: 0-150 mg/kg
  • Administration: 口服饲喂
    (Only for Reference)

溶解度 (25°C)

体外 Water 30 mg/mL (61.98 mM)
DMSO 3 mg/mL warmed (6.19 mM)
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
Saline
6 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 483.99
化学式

C24H29N7O2.HCl

CAS号 827022-32-2
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03472573 Recruiting Recurrent B Acute Lymphoblastic Leukemia|Refractory B Acute Lymphoblastic Leukemia Sidney Kimmel Cancer Center at Thomas Jefferson University|Pfizer|Thomas Jefferson University May 9 2018 Phase 1
NCT03423199 Recruiting Breast Neoplasms National Cancer Center Japan|Pfizer|Korean Cancer Study Group February 9 2018 Phase 3
NCT03147287 Recruiting Metastatic Breast Cancer Dana-Farber Cancer Institute|Pfizer August 9 2017 Phase 2
NCT02905318 Recruiting Prostate Cancer Canadian Cancer Trials Group|Pfizer February 9 2017 Phase 2
NCT02679755 Recruiting Breast Cancer Pfizer March 9 2016 Phase 4
NCT03284957 Recruiting Breast Cancer Sanofi September 8 2017 Phase 1|Phase 2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID