Palbociclib (PD-0332991) HCl

For research use only. Not for use in humans.

Pfizer辉瑞授权 目录号:S1116

Palbociclib (PD-0332991) HCl Chemical Structure

Molecular Weight(MW): 483.99

Palbociclib (PD-0332991) HCl是一种高度选择性的CDK4/6抑制剂,无细胞试验中IC50分别为11 nM/16 nM。它对CDK1/2/5,EGFR,FGFR,PDGFR,InsR等没有抑制活性。Phase 3。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1801.8 现货
RMB 902.49 现货
RMB 1406.17 现货
RMB 4670.26 现货
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客户使用Selleck生产的Palbociclib (PD-0332991) HCl发表文献167篇:

产品安全说明书

CDK抑制剂选择性比较

生物活性

产品描述 Palbociclib (PD-0332991) HCl是一种高度选择性的CDK4/6抑制剂,无细胞试验中IC50分别为11 nM/16 nM。它对CDK1/2/5,EGFR,FGFR,PDGFR,InsR等没有抑制活性。Phase 3。
特性 PD-0332991作为有应用前景的工具测定CDK激酶是否具有明显的治疗价值。
靶点
CDK4/CyclinD3 [1]
(Cell-free assay)
CDK4/CyclinD1 [1]
(Cell-free assay)
CDK6/CyclinD2 [1]
(Cell-free assay)
9 nM 11 nM 15 nM
体外研究

PD 0332991 对其他蛋白激酶包括EGFR, FGFR, PGFR, IR等没有抑制效果。 PD 0332991作用于Cdk4时是非ATP竞争性抑制剂。PD 0332991抑制MDA-MB-435乳腺癌细胞,IC50为66 nM,是由于Rb 在Ser780的磷酸化作用下降。PD 0332991抑制胸苷合并到Rb阳性的人类乳腺癌,结肠癌 肺癌,及白血病的DNA中,IC50值为4 nM到0.17 μM。PD 0332991作用于Rb阴性细胞没有抑制效果。PD 0332991作用于MDA-MB-453乳腺癌细胞和结肠-205细胞使细胞积累在G1期。[1]PD 0332991也有效作用于骨髓瘤5T33MM细胞,使细胞对Bortezomib敏感。[2]PD 0332991抑制luminalER-阳性和HER2-增强的乳腺癌细胞系,包括MDA-MB-175 ZR-75-30 CAMA-1 MDA-MB-134 HCC-202 UACC-893 等等。在这些细胞系中,PD 0332991增强Tamoxifen和Trastuzumab 的活性。在MCF7抗Tamoxifen细胞中,PD 0332991也增强tamoxifen 的敏感性。[3] 最新研究显示PD 0332991可以抑制恶性横纹肌样肿瘤(MRT)细胞系包括MP-MRT-AN, KP-MRT-RY, G401, KP-MRT-NS,且MRT细胞系对PD 0332991敏感性和p16表达呈负相关。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MOLM13 NEftNGZMcW6jc3WgRZN{[Xl? MmrONlQhcA>? NVPmVnlDUW6qaXLpeIlwdiCxZjDDSGs1KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhWmJicHjvd5Bpd3K7bHH0bY9vKHerdHigTWM2OCCxZjCwMlAxOiEQvF2= MoXBNlQ3PDFzMEO=
COLO205 NHyzcINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYC3NkBp NGrz[W1CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3Onc4Pl[EBieyCrbnPvdpBwemG2aX;uJI9nKFt|SG30bJlucWSrbnWgbY51dyCGTlGge4l1cCCLQ{WwJI9nKDBwMEO2JO69VQ>? NX3BVY97OjR4NEGxNFM>
U937 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUK3NkBp NWH4OZQzSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|ZYPz[YQh[XNiaX7jc5Jxd3KjdHnvckBw\iCdM1jdeIh6dWmmaX7lJIlvfG9iRF7BJJdqfGhiSVO1NEBw\iByLkG0JO69VQ>? M3T5[FI1PjRzMUCz
MOLM13 NHTWcGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPJVG44OiCq NV:5XHQ3SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNU2xOOTNiY3XscJMhcGG{Yn;ybY5oKE[OVEOgTXRFKG23dHHueEBie3Onc4Pl[EBieyCrbnPvdpBwemG2aX;uJI9nKFt|SG30bJlucWSrbnWgbY51dyCGTlGge4l1cCCLQ{WwJI9nKDBwMEm2JO69VQ>? MXGyOFY1OTFyMx?=
MOLM13 M4HOe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrGO|IhcA>? Mn;LRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDzc5Ji\mWwaXKtdoV{cXO2YX70JIh2dWGwIF3PUG0yOyClZXzsd{Bie3Onc4Pl[EBieyCrbnPvdpBwemG2aX;uJI9nKFt|SG30bJlucWSrbnWgbY51dyCGTlGge4l1cCCLQ{WwJI9nKDBwMEm2JO69VQ>? NFX5U|gzPDZ2MUGwNy=>
MDA-MB-435 NITKNJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWmyOEBp NWWwPVF3UUN3ME2wMlE3KM7:TR?= Mnv0NVU5ODF6M{G=
K562 MXnDfZRwfG:6aXOgRZN{[Xl? NEK5fnc6PiCq MUTEUXNQ NFPLe2FKSzVyPUKg{txO MVuyOFQyPzV4Nh?=
DU145 NVrIOJdqS3m2b4TvfIlkKEG|c3H5 Ml\VPVYhcA>? NXL0fYxITE2VTx?= M4[5U2lEPTB;Nz61JO69VQ>? NXjhTldrOjR2MUe1OlY>
MDA-MB-231 NGnLNYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV2xJO69VQ>? MYWyOEBp MWjEUXNQ MX\D[YxtKGO7Y3zlJIFzemW|dDDhd5Nme3OnZDDhd{Bi[2O3bYXsZZRqd25iYYSgS|EheGijc3W= NIniNpkzPDRzN{W2Oi=>
MCF7 MnjXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWCxJO69VQ>? NYjyZWVvOjRiaB?= NGTHNJhFVVOR MYfD[YxtKGO7Y3zlJIFzemW|dDDhd5Nme3OnZDDhd{Bi[2O3bYXsZZRqd25iYYSgS|EheGijc3W= NGK5fJAzPDRzN{W2Oi=>
MCF7 M1mxPWtqdmG|ZTDBd5NigQ>? M1XJSFUh|ryP MnPoNlQhcA>? NVvKNm5oTE2VTx?= NIX1[3JKdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JGNFUzRxY4njcIlvTDFiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC{ZYTpco9jdGG|dH;tZUBxcG:|cHjvdplt[XSrb36gZZQhW2W{N{iw NFq2TpEzPDRzN{W2Oi=>
MDA-MB-231 NFvFPVNMcW6jc3WgRZN{[Xl? MV:1JO69VQ>? MWCyOEBp M4nHT2ROW09? MoPCTY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDDSGs1N2O7Y3zpcmQyKGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhemW2aX7vZoxie3SxbXGgdIhwe3Cqb4L5cIF1cW:wIHH0JHNmejd6MB?= M1ja[|I1PDF5NU[2
MDA-MB-231 NHznTIxHfW6ldHnvckBCe3OjeR?= NIDETGgyNTFyIN88US=> MUeyOEBp NXn1dpNUTE2VTx?= MnrS[I9meyCwb4SgbY5lfWOnIHHwc5B1d3OrczDhd5Nme3OnZDDhd{BRSVKSIHPs[YF3[Wen MoryNlQ1OTd3Nk[=
MCF7 M2fDO2Z2dmO2aX;uJGF{e2G7 NILLSW0yNTFyIN88US=> MoSwNlQhcA>? Mn76SG1UVw>? M{LNbIRw\XNibn;0JIlv\HWlZTDhdI9xfG:|aYOgZZN{\XO|ZXSgZZMhWEGUUDDjcIVifmGpZR?= Mo\RNlQ1OTd3Nk[=
MDA-MB-231 MYDGeY5kfGmxbjDBd5NigQ>? NYrMOGk3OC53LUGg{txO NHK2b|A1QCCq NIPKOWFFVVOR M4O2OohieyCwbzDD[YxtKGO7Y3zlJIFzemW|dDDhd5Nme3OnZDDhd{Bi[2O3bYXsZZRqd25iYYSgd5VjNUdzIIDoZZNm NGnINXAzPDRzN{W2Oi=>
MCF7 NH60c2VHfW6ldHnvckBCe3OjeR?= Ml3kNE42NTFizszN MXy0PEBp NYDuRXY3TE2VTx?= M3XnUohieyCwbzDD[YxtKGO7Y3zlJIFzemW|dDDhd5Nme3OnZDDhd{Bi[2O3bYXsZZRqd25iYYSgd5VjNUdzIIDoZZNm M4DzcVI1PDF5NU[2
697 MnPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XzdGlEPTB;MUS4MlM5KG6P NFTEZ|FUSU6JRWK=
P12-ICHIKAWA NUnG[Xd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHBdHBKSzVyPUm2MlA1KG6P MXfTRW5ITVJ?
NB69 NVjmcI51T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17EVmlEPTB;MU[xMlghdk1? MlvPV2FPT0WU
EoL-1 M1XYOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\sTWM2OD1zOEeuNlYhdk1? MVrTRW5ITVJ?
BHT-101 NEPRTotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWW5THE2UUN3ME2xPVgvOjVibl2= MkXCV2FPT0WU
SK-NEP-1 MmL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTJ{MD6wNkBvVQ>? NH7GblNUSU6JRWK=
MHH-NB-11 MonlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTJ{MD6xPUBvVQ>? MmfCV2FPT0WU
AsPC-1 NUK1WHRNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTJ3Mj61N{BvVQ>? MkXjV2FPT0WU
ES1 NEjaVGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTJ3Nj6yOUBvVQ>? NUjB[JJwW0GQR1XS
LAMA-84 M1nSRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1G3RWlEPTB;MkW4MlE6KG6P MUjTRW5ITVJ?
MOLT-16 M{Tze2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInWUopKSzVyPUK1PE41QSCwTR?= MkC0V2FPT0WU
ES7 NXHJ[npxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPqTWM2OD1{N{OuNFkhdk1? MlnuV2FPT0WU
KY821 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrKTWM2OD1|MUSuNUBvVQ>? MXLTRW5ITVJ?
RT-112 NUHSUWpZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTN{MT6wOUBvVQ>? NGH0S2VUSU6JRWK=
HL-60 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTN2MD62OkBvVQ>? MnXKV2FPT0WU
MOLT-4 M3zyT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnL2TWM2OD1|NEWuNVMhdk1? MXfTRW5ITVJ?
KARPAS-45 NXTsS5VMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXT2dY1PUUN3ME2zO|YvOTZibl2= MY\TRW5ITVJ?
SK-N-AS M{HCOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTN6Nz64N{BvVQ>? MlL1V2FPT0WU
CTB-1 NXy5RodvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnX1TWM2OD12MEWuNFIhdk1? Ml7UV2FPT0WU
NKM-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvkcYFKSzVyPUSxNU45QSCwTR?= MWLTRW5ITVJ?
HTC-C3 M2rFfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DPb2lEPTB;NEOyMlk2KG6P M4PUenNCVkeHUh?=
BE-13 M2Pkc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zKNGlEPTB;NES0MlI4KG6P MlPOV2FPT0WU
KOSC-2 NEe4OnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTR4Nj65JI5O NVvOe4tIW0GQR1XS
NB14 MlmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXK4c41rUUN3ME20PFMvPThibl2= NWf0SpZ3W0GQR1XS
CAL-27 M{X6d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEG1N3ZKSzVyPUS5OE42QSCwTR?= M3n0RXNCVkeHUh?=
H9 NVr0UHo5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTR7NT60N{BvVQ>? MVzTRW5ITVJ?
RS4-11 NWn0SZFPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zxRWlEPTB;NUC0Mlc{KG6P NHe2XmZUSU6JRWK=
PA-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEOwc5FKSzVyPUWwPU45PiCwTR?= Ml3YV2FPT0WU
MV-4-11 M{nHPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;lfGlEPTB;NUGzMlg2KG6P MULTRW5ITVJ?
OS-RC-2 MkmzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDDbpJSUUN3ME21NlEvPjJibl2= NHfJXoFUSU6JRWK=
RPMI-8226 NEDVSGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fmUGlEPTB;NUK2Mlg3KG6P MXnTRW5ITVJ?
HGC-27 M4rufmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknVTWM2OD13NkSuPVkhdk1? NF3LXHVUSU6JRWK=
CHP-212 M4\TSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{O4OGlEPTB;NUmzMlU6KG6P MmPjV2FPT0WU
NB10 M1\lNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXvSYhKSzVyPUW5PU4yQCCwTR?= NVvKboZPW0GQR1XS
HH NYDkSlVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTV7OT60N{BvVQ>? M2qxW3NCVkeHUh?=
EW-16 M4XGdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTZyMz61NkBvVQ>? NYfCeGpxW0GQR1XS
ES8 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLPTWM2OD14MEWuNlEhdk1? MlHMV2FPT0WU
HAL-01 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYG5cXY5UUN3ME22NFUvPjdibl2= NIfBSVBUSU6JRWK=
A204 M1zZNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTZ|Mz65NUBvVQ>? MlTXV2FPT0WU
MHH-PREB-1 M1:2XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHO3eZhKSzVyPU[zOk46QSCwTR?= MUHTRW5ITVJ?
EM-2 MmHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PH[2lEPTB;NkWwMlY1KG6P MmXtV2FPT0WU
BV-173 NHnIXGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEK2SVNKSzVyPU[1Nk41QCCwTR?= NEPsbI5USU6JRWK=
ONS-76 NULPWWw3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnM[3ZKSzVyPU[3O{45OiCwTR?= M3TLdnNCVkeHUh?=
KM-H2 M4TxZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYWyTJpSUUN3ME22PVUvPTRibl2= NX3WRZVtW0GQR1XS
D-263MG MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7DTYRLUUN3ME23NVcvOTJibl2= MnHpV2FPT0WU
ES3 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTd{OD65N{BvVQ>? NU\5[JY4W0GQR1XS
VA-ES-BJ M{HibWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXUTWM2OD15M{KuNlchdk1? MUfTRW5ITVJ?
NBsusSR MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTd2Mj65PUBvVQ>? MYrTRW5ITVJ?
NCI-H520 M1HXbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTd2Nj61NkBvVQ>? MlfQV2FPT0WU
ES5 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHrTWM2OD15NUKuPEBvVQ>? NGTEV4xUSU6JRWK=
T-24 M4TCWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3Tob2lEPTB;N{e4MlcyKG6P MkfvV2FPT0WU
SW962 MnnwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPaOo9KSzVyPUiwPE43OyCwTR?= M2jVOXNCVkeHUh?=
EW-3 M3LieGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonQTWM2OD16MEiuO|Yhdk1? NX30VYI2W0GQR1XS
RXF393 NFTSZohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;CZmlEPTB;OEGyMlc6KG6P NIHveIVUSU6JRWK=
U251 NWnXVHpoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTxTWM2OD16MUOuPFghdk1? M4r5OHNCVkeHUh?=
CAMA-1 MliwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLmTWM2OD16M{OuPVQhdk1? NGK4UW9USU6JRWK=
JVM-3 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLLd2lKUUN3ME24OVEvPzhibl2= NI\6eWlUSU6JRWK=
COLO-800 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjrdXlqUUN3ME24PVcvPzhibl2= NWTRWYNtW0GQR1XS
OVCAR-5 M2jzc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo[0TWM2OD17MECuNUBvVQ>? MVHTRW5ITVJ?
LB1047-RCC MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjBTWM2OD17MkeuOVYhdk1? Mm\aV2FPT0WU
SW954 M3LyV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vCW2lEPTB;OUK5MlQyKG6P NUfQO3JFW0GQR1XS
J-RT3-T3-5 Mor1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUX3R|FZUUN3ME25N|YvODZibl2= NFrIZXRUSU6JRWK=
Mewo NETCfndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzzWGFIUUN3ME25N|YvPiCwTR?= NFT6OnVUSU6JRWK=
NCI-H1770 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoOxTWM2OD17NECuOVUhdk1? MXHTRW5ITVJ?
HO-1-N-1 M{nje2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUj5WIFnUUN3ME25OlIvQDFibl2= NH;WTHlUSU6JRWK=
HSC-3 NEDNSWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFq2UGRKSzVyPUm2Ok41QCCwTR?= MXfTRW5ITVJ?
TYK-nu Mkn2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnaTWM2OD17OUiuNlUhdk1? MUjTRW5ITVJ?
KYSE-150 NHjvcGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTFwMECwO|Yh|ryP NYLlS|JPW0GQR1XS
SN12C NHvRdm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLleZBSUUN3ME2xMlAxQDd3IN88US=> NWPKT3FqW0GQR1XS
MOLT-13 M2m1Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPGTWM2OD1zLkCxOFIyKM7:TR?= MWPTRW5ITVJ?
TE-11 MlLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTFwMES4NVIh|ryP MmDNV2FPT0WU
DB MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnlOmhKSzVyPUGuNFczPzNizszN Mo\0V2FPT0WU
CAL-39 NVPU[nJKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;OTWM2OD1zLkC3OVIzKM7:TR?= MVjTRW5ITVJ?
A3-KAW NGLxUW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIn1U4RKSzVyPUGuNFg1ODhizszN Ml;IV2FPT0WU
CHP-134 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TFe2lEPTB;MT6xNVgxPyEQvF2= Mo[1V2FPT0WU
TGW NW[yU4FQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTFwMUKzPVUh|ryP M3LlcnNCVkeHUh?=
QIMR-WIL NEn4NFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLNUWVKSzVyPUGuNVMyOzRizszN MUnTRW5ITVJ?
NCI-SNU-1 MnnkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTFwMU[zOVQh|ryP NF3X[oZUSU6JRWK=
CGTH-W-1 M3nBO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTSRWp2UUN3ME2xMlE4OTh4IN88US=> MlrJV2FPT0WU
MHH-ES-1 MoTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTFwMUe5PFYh|ryP MWnTRW5ITVJ?
LB2241-RCC NYDhRWhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTFwMUi2NkDPxE1? NHnTe|JUSU6JRWK=
ML-2 NIK1NGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\NTWM2OD1zLkKwO|M1KM7:TR?= MXrTRW5ITVJ?
COR-L23 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTFwMkK5N|Mh|ryP MoKyV2FPT0WU
BFTC-905 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTFwMkSyOlch|ryP MUDTRW5ITVJ?
Hs-578-T M3rNOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTOfJVKSzVyPUGuNlU5OTdizszN NXL3[JY2W0GQR1XS
KG-1 MoftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGL1ZpNKSzVyPUGuNlY3QDZizszN M3;hSnNCVkeHUh?=
HEL NXOyWVlwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXzRVdKUUN3ME2xMlI6OzN6IN88US=> MkHWV2FPT0WU
A549 NEfVfIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{[3VGlEPTB;MT6yPVM6QSEQvF2= M2TyR3NCVkeHUh?=
COLO-741 NFPY[Y9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2e5ZWlEPTB;MT6zNlA5QSEQvF2= MV7TRW5ITVJ?
PC-3 M3mxeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTFwM{WyNlEh|ryP MlTXV2FPT0WU
HOS MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGr0SJlKSzVyPUGuN|UzQTZizszN Mn7lV2FPT0WU
HT-1080 MnzNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\UTWM2OD1zLkO3OVE6KM7:TR?= Mn;pV2FPT0WU
TE-8 MoHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHpTWM2OD1zLkSxO|c1KM7:TR?= NXGxe4xGW0GQR1XS
BHY NUGyTndMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTKV2tKSzVyPUGuOFY6OjNizszN NV7WNJJ7W0GQR1XS
BB65-RCC NX\TeGcxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LX[WlEPTB;MT61NFUzQCEQvF2= MkGzV2FPT0WU
HN NFXEc5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fjSGlEPTB;MT61OFA4OSEQvF2= NWLxc21VW0GQR1XS
NCI-H441 M4rJeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnob|lKSzVyPUGuOVQ6ODdizszN MlPlV2FPT0WU
RPMI-8866 Mof2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzkWpRbUUN3ME2xMlU5PTB5IN88US=> MX3TRW5ITVJ?
CAL-62 M{jocmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHr1cYdKSzVyPUGuOlA5PjJizszN MUjTRW5ITVJ?
MG-63 NHv3UZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTFwNkG4NVMh|ryP MUPTRW5ITVJ?
SK-LU-1 NX\WPGVmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWf3SHVxUUN3ME2xMlYzOTV{IN88US=> MWHTRW5ITVJ?
BCPAP MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDKdJFKSzVyPUGuOlY1PTdizszN NIjmbGJUSU6JRWK=
22RV1 NW\oOXRIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjSNXZ{UUN3ME2xMlY4QDR|IN88US=> MYnTRW5ITVJ?
T47D NIPNXmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTFwNkiwOlEh|ryP MYPTRW5ITVJ?
MSTO-211H NInNfpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vycWlEPTB;MT62PVYxOyEQvF2= MofBV2FPT0WU
DEL Mo[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmX6TWM2OD1zLkewNlc{KM7:TR?= MYPTRW5ITVJ?
H4 MoHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDnTWM2OD1zLkezNlEzKM7:TR?= NXLSUFQ2W0GQR1XS
CAL-51 NUPVfGVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTFwN{S4OVUh|ryP M3fyXHNCVkeHUh?=
ABC-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnuTWM2OD1zLke4OVgzKM7:TR?= NFvQboJUSU6JRWK=
MZ2-MEL MorJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTFwN{m1OFIh|ryP NVrOc4NNW0GQR1XS
YKG-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M174TGlEPTB;MT64NVA3OSEQvF2= MYLTRW5ITVJ?
KM12 MoPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;oflliUUN3ME2xMlgyPjB{IN88US=> MnO2V2FPT0WU
L-363 MnixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTFwOEe0NVIh|ryP NEjzO4RUSU6JRWK=
KU812 M1TRS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvLOopKSzVyPUGuPFkzQDJizszN M3\UcnNCVkeHUh?=
LOXIMVI NXPBVWg5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTFwOUGyNlgh|ryP MlP4V2FPT0WU
G-401 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\COWVKSzVyPUGuPVI1OjhizszN NHTjfphUSU6JRWK=
SW780 MoPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTFwOU[yOFYh|ryP MUPTRW5ITVJ?
SW872 NVnvXYtiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;GOpJkUUN3ME2xMlk5OzNizszN NIjaV|FUSU6JRWK=
NB7 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HNNWlEPTB;MT65PVMzOyEQvF2= M{jVNHNCVkeHUh?=
T98G NULoUng6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rXW2lEPTB;Mj6wNFY3PiEQvF2= MYTTRW5ITVJ?
SW1710 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rWeGlEPTB;Mj6wOlk1PSEQvF2= M4DzO3NCVkeHUh?=
NCI-H1573 M3LVU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTJwMEeyPVgh|ryP M1y0Z3NCVkeHUh?=
KE-37 Mn20S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfKWXhKSzVyPUKuNFg6PTFizszN MXrTRW5ITVJ?
786-0 NGflT4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLIcZhKSzVyPUKuNVU1OzlizszN NW\KWohQW0GQR1XS
SAS M{jpfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrwTWM2OD1{LkKwN|c1KM7:TR?= MnntV2FPT0WU
CAL-54 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnLTWM2OD1{LkKwOFE{KM7:TR?= MlHvV2FPT0WU
SF268 Mlr0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jPbGlEPTB;Mj6yN|EzOiEQvF2= NHPyNpZUSU6JRWK=
SW620 MmDDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2n4e2lEPTB;Mj6yOlE3QSEQvF2= MWXTRW5ITVJ?
MN-60 NF\TZlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjSTWM2OD1{LkOxNFYh|ryP Mm\SV2FPT0WU
EFO-27 NY\ycFY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTJwM{KwOVgh|ryP MWXTRW5ITVJ?
NCI-H747 MoC4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TUWmlEPTB;Mj6zNlE6QSEQvF2= NH\2PYtUSU6JRWK=
HCC2218 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUO0SJlDUUN3ME2yMlM2Ozd2IN88US=> NGXv[4dUSU6JRWK=
MIA-PaCa-2 NX7MOGZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHpTWM2OD1{LkO2OFM4KM7:TR?= MVLTRW5ITVJ?
SJSA-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7PZ3ZqUUN3ME2yMlM4Pzl4IN88US=> M17LVHNCVkeHUh?=
RKO MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fMW2lEPTB;Mj6zPFQ6PiEQvF2= NXztc|FoW0GQR1XS
NB6 NHvrNVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljMTWM2OD1{LkSwN|c1KM7:TR?= MWrTRW5ITVJ?
ES4 NH;vS|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjZeVBKSzVyPUKuOFU1OjJizszN NIDFV2JUSU6JRWK=
EGI-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1H5OWlEPTB;Mj60Olg5OyEQvF2= M335PHNCVkeHUh?=
CTV-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTJwNUK3O|Mh|ryP NYjIcmJoW0GQR1XS
NCI-H1355 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzRTWM2OD1{LkW1PVUyKM7:TR?= NGfJbJlUSU6JRWK=
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GAMG Mn[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTJwNUmzPVQh|ryP M3TUW3NCVkeHUh?=
SK-MES-1 M{PQeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHHdY5rUUN3ME2yMlYyQDB|IN88US=> NFPkZ|RUSU6JRWK=
RO82-W-1 MmTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTJwNkKwOVch|ryP MlHrV2FPT0WU
ECC10 MlSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTJwN{CyNFYh|ryP MmjBV2FPT0WU
MCF7 MnPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jJU2lEPTB;Mj63NVQ3PCEQvF2= NV7RclVIW0GQR1XS
D-283MED MnO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LkbGlEPTB;Mj63NlQ{KM7:TR?= MUjTRW5ITVJ?
RPMI-7951 NInyNnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUO2NY9vUUN3ME2yMlc2Pjl2IN88US=> NF6wc4VUSU6JRWK=
Ramos-2G6-4C10 M1ryXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTJwN{ewPVkh|ryP M1rwWXNCVkeHUh?=
KGN NHKzfWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvwXIZYUUN3ME2yMlgyQDh2IN88US=> MkTIV2FPT0WU
NUGC-3 MnLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjZfo0xUUN3ME2yMlgzPTB3IN88US=> NYHYdVhsW0GQR1XS
NCI-H292 M4ThVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPhTWM2OD1{Lki1NFU{KM7:TR?= MXvTRW5ITVJ?
Becker NY\CcVg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTJwOUW4N|Ih|ryP NYnVW|Q5W0GQR1XS
NCI-H1299 M4Psd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfLTWM2OD1|LkC1NlY{KM7:TR?= MUHTRW5ITVJ?
ETK-1 MlPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;Id4pKSzVyPUOuNFU1OyEQvF2= M3ri[HNCVkeHUh?=
TK10 Mn;NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjKdodnUUN3ME2zMlIxOTZ3IN88US=> MW\TRW5ITVJ?
VMRC-RCZ MmjmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXZdlh[UUN3ME2zMlM3PDh6IN88US=> Mo\1V2FPT0WU
YH-13 NHnUd2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;vTWM2OD1|LkS0NFc6KM7:TR?= MX;TRW5ITVJ?
DU-145 M3;aVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\1cmlEPTB;Mz60OlI3QSEQvF2= NYfS[WRrW0GQR1XS
SW1088 NWm0eIhET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jocWlEPTB;Mz60O|Q4KM7:TR?= MmLUV2FPT0WU
HOP-92 M3LqXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTNwNUCzOFIh|ryP NFL6fJZUSU6JRWK=
KP-N-YS NVH3ZpM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PTUmlEPTB;Mz62NlE{QSEQvF2= M2[3cHNCVkeHUh?=
NCI-H460 M2\L[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTXXoUyUUN3ME2zMlY3PzNizszN Mkm3V2FPT0WU
U-2-OS NVjvelM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTNwN{K1N|Uh|ryP NVnMVXEzW0GQR1XS
A101D M2X1WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTNwN{[5N|Yh|ryP Ml7IV2FPT0WU
MDA-MB-231 NFv0b2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXsfVhuUUN3ME2zMlgyQTVzIN88US=> M16xV3NCVkeHUh?=
IST-MES1 M4K2OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\kO5dKSzVyPUOuPFMzKM7:TR?= M1nHc3NCVkeHUh?=
COR-L105 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfzTWM2OD12LkCxPEDPxE1? MXzTRW5ITVJ?
NCI-H1437 NHH4NFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU[3XVJZUUN3ME20MlAzOzB{IN88US=> M13aOHNCVkeHUh?=
CAL-85-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTRwMEK0OlEh|ryP MoP1V2FPT0WU
MZ1-PC NH3DZY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnT1TWM2OD12LkG4OVU3KM7:TR?= MUHTRW5ITVJ?
VM-CUB-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTRwM{GyPFQh|ryP NWrLdpp3W0GQR1XS
CHL-1 NY\Z[GRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3ZO2ZmUUN3ME20MlMzOTZ7IN88US=> MUHTRW5ITVJ?
MDA-MB-361 MnvHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2L2VGlEPTB;ND6zN|E2OyEQvF2= M4XafXNCVkeHUh?=
NCI-H661 MmruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTRwNUCwPVIh|ryP MVTTRW5ITVJ?
EW-11 M1n2S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTRwNUKyN|Eh|ryP Mnm4V2FPT0WU
BEN MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XnS2lEPTB;ND61NlgyPSEQvF2= NYXNSnFGW0GQR1XS
BFTC-909 NVewVoNmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4radWlEPTB;ND61OlI4PSEQvF2= MXjTRW5ITVJ?
NCI-H2087 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M333bWlEPTB;ND61PFE3PCEQvF2= Mo\QV2FPT0WU
RVH-421 NGK2[3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVu0WGd1UUN3ME20MlY3PjlizszN M3q0NnNCVkeHUh?=
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NCI-H28 NHzBOnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jCVmlEPTB;ND64NVY3OSEQvF2= M2Xmc3NCVkeHUh?=
ES6 M{TBR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmD0TWM2OD12LkizNFE3KM7:TR?= M{XTN3NCVkeHUh?=
769-P M1SzfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTRwOEW5NlYh|ryP MWLTRW5ITVJ?
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SW982 M1\Y[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEH0cGpKSzVyPUSuPVUxPjFizszN NEfBN5dUSU6JRWK=
A388 NHfkZYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTVwMEK5PFMh|ryP M13SWXNCVkeHUh?=
TI-73 MmjUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3f4b2lEPTB;NT6wOlE6PCEQvF2= NGDUd49USU6JRWK=
HCT-116 MlzoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTJfVhPUUN3ME21MlA6QDh7IN88US=> MX3TRW5ITVJ?
HuP-T3 NVvmPJZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fXSWlEPTB;NT6xPFcxQSEQvF2= MX3TRW5ITVJ?
G-402 NUi3XpJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTVwMUm0NVYh|ryP M1v6fnNCVkeHUh?=
NCI-H1792 M{DQbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzsOIp{UUN3ME21MlI1PjJ{IN88US=> M2G1UHNCVkeHUh?=
NCI-H209 MnnFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37xUWlEPTB;NT6yOVk1OiEQvF2= NX\6T|BFW0GQR1XS
NCI-H1650 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HIO2lEPTB;NT6zNFY{PCEQvF2= NGDLbXBUSU6JRWK=
LCLC-97TM1 NWTWWVlvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXXTWM2OD13LkOxPFA5KM7:TR?= M3PEWXNCVkeHUh?=
S-117 Mk\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2SyXmlEPTB;NT6zOlk4PiEQvF2= NHv1RlRUSU6JRWK=
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A427 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfROGNKSzVyPUG4MlUxQTRizszN MXrTRW5ITVJ?
HCC2998 M1\pXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTF6Lk[wOVEh|ryP M{e4UnNCVkeHUh?=
EPLC-272H NXLXSIdIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPjTWM2OD1zOT6wOFM1KM7:TR?= NFXJ[VhUSU6JRWK=
C32 M4DzN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXmSXRKUUN3ME2xPU4xPDVizszN NV\KV4liW0GQR1XS
UMC-11 M3\yO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrUd21KSzVyPUG5MlIyOjNizszN MlO3V2FPT0WU
CaR-1 MoXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTF7Lk[4NFQh|ryP NITKfHVUSU6JRWK=
KYSE-410 M{jZdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfuOHlwUUN3ME2xPU46OTN7IN88US=> NULUV4RFW0GQR1XS
HuCCT1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTJyLk[yPVQh|ryP NVXqPVl1W0GQR1XS
LB996-RCC MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\oVYpKSzVyPUKwMlcyPjhizszN MVPTRW5ITVJ?
KYSE-70 M{faZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTJyLkiwOVkh|ryP M2fWcXNCVkeHUh?=
CAL-72 MlrLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjI[WZkUUN3ME2yNE46OTVizszN M174fXNCVkeHUh?=
Capan-2 M33keGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkmzTWM2OD1{MT6wOFE{KM7:TR?= Ml;XV2FPT0WU
PANC-08-13 NXPmcoNZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\4N2lEPTB;MkGuNlUyPSEQvF2= Ml;mV2FPT0WU
SBC-1 NX60SHAyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTJzLkOwPFEh|ryP NXfmWIpyW0GQR1XS
MFM-223 MmfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTJzLkOzOFIh|ryP M2LOWnNCVkeHUh?=
BB49-HNC NXHhU41MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGK3[4pKSzVyPUKxMlU4OTZizszN NGDROlNUSU6JRWK=
SH-4 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrPTXRKSzVyPUKxMlY3OThizszN NVqyWGJEW0GQR1XS
HuO9 M2fCN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlizTWM2OD1{MT65PFI2KM7:TR?= Mn3FV2FPT0WU
AM-38 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDzTWM2OD1{Mj6wOFg2KM7:TR?= MVvTRW5ITVJ?
A431 NHjhbnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mon5TWM2OD1{Mz6yNVE6KM7:TR?= MWDTRW5ITVJ?
YAPC NIHQWpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWezOld[UUN3ME2yN{4zPjVzIN88US=> NYHGU5p1W0GQR1XS
LU-139 NUXOfplNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHrVYVKSzVyPUKzMlQ5ODlizszN NIPSR3hUSU6JRWK=
HEC-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7MTWM2OD1{Mz60PVM4KM7:TR?= MVXTRW5ITVJ?
SCC-25 NH;RR2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPOTWM2OD1{ND6zNFA3KM7:TR?= NVjmSFdNW0GQR1XS
HT-29 M{j1OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\TTWM2OD1{ND6zPFI{KM7:TR?= NFO5eGpUSU6JRWK=
PC-14 NYfre4V[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTJ2Lk[1O|Eh|ryP NIeySYxUSU6JRWK=
Calu-6 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDSTWM2OD1{NT61NFcyKM7:TR?= NFOwXXJUSU6JRWK=
SJRH30 NX3lZpM4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTJ3Lk[0PVYh|ryP MXfTRW5ITVJ?
ChaGo-K-1 M{TxRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYq5UYxGUUN3ME2yOk4yPjJ7IN88US=> M3PFR3NCVkeHUh?=
IA-LM MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTJ4LkO2OFUh|ryP MXXTRW5ITVJ?
GP5d MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\CXGlEPTB;Mk[uOFQ6OSEQvF2= M1yxRnNCVkeHUh?=
NCI-H2291 NYPXfpRwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjIWXZxUUN3ME2yOk43PTRzIN88US=> MVTTRW5ITVJ?
BALL-1 M3HydWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoCyTWM2OD1{Nj65N|k4KM7:TR?= NEPFRXFUSU6JRWK=
HCC1954 MoriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XoZWlEPTB;Mk[uPVgxQCEQvF2= NHThfVVUSU6JRWK=
NCI-H2452 NH21eIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnqd4hKSzVyPUK3MlQyPjNizszN NHLkeFBUSU6JRWK=
LU-99A NUnCNZZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTJ5LkW1PFIh|ryP NXXCWY05W0GQR1XS
NTERA-S-cl-D1 NUewWIpTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfxTWM2OD1{Nz63Nlk6KM7:TR?= M{jKZ3NCVkeHUh?=
PANC-10-05 NXnVfmxET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3X4cmlEPTB;MkeuO|c4PSEQvF2= MVXTRW5ITVJ?
NCI-H2405 NUnq[IlLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoL2TWM2OD1{Nz65N|g4KM7:TR?= MUfTRW5ITVJ?
MDA-MB-415 MonaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3sTWM2OD1{OD60NVM4KM7:TR?= MlzkV2FPT0WU
NCI-H2342 M3m1fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjn[4F2UUN3ME2yPE42OjhzIN88US=> MWnTRW5ITVJ?
TGBC24TKB M4HBe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHtfWw{UUN3ME2yPE44OTF5IN88US=> M361SnNCVkeHUh?=
LU-134-A NXnOS49yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjpTWM2OD1{OD65NlYyKM7:TR?= MkXxV2FPT0WU
SCC-4 M4SwfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfZTWM2OD1|MT6wOFk1KM7:TR?= MkflV2FPT0WU
Saos-2 MljaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTNzLkmzNFYh|ryP M4e0NHNCVkeHUh?=
RERF-LC-MS NVvtRXZ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TnOWlEPTB;M{KuPFI{OSEQvF2= M2P1PHNCVkeHUh?=
M14 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\ITWM2OD1|Mj65O|Y1KM7:TR?= M2LKbXNCVkeHUh?=
HPAF-II NXj6PIxqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPmTWM2OD1|Mz61NFEyKM7:TR?= MUnTRW5ITVJ?
NCI-H1755 NHSwU4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPvdlBjUUN3ME2zOE4{OzB3IN88US=> NVTEWWR7W0GQR1XS
D-392MG NUPuUI5iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPaNHFKSzVyPUO1Mlg3PzRizszN M2fvN3NCVkeHUh?=
A704 NH7xfXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHLSJZVUUN3ME2zOk4xPDJ5IN88US=> MWnTRW5ITVJ?
CP50-MEL-B MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrIN3pKSzVyPUO2MlE6OTFizszN Mn\RV2FPT0WU
EW-18 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTN4LkS1NkDPxE1? NYPkV4lXW0GQR1XS
WM-115 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLYTWM2OD1|Nj64NFk6KM7:TR?= MWnTRW5ITVJ?
LU-65 NIi0VHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLJTWM2OD1|Nz6xOFE4KM7:TR?= NVjORY51W0GQR1XS
NCI-H1563 Mlr3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrZ[JR1UUN3ME2zO{4zPDh2IN88US=> NGK3SZhUSU6JRWK=
DBTRG-05MG Mm\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFOxRYJKSzVyPUO4MlA3QTFizszN MnzEV2FPT0WU
NCI-H630 MonwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTN6LkS3NVQh|ryP MVHTRW5ITVJ?
NCI-H1155 NHnQeGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2X6TWlEPTB;M{muNlQzKM7:TR?= NYD1[WdmW0GQR1XS
OVACR-3 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTN7LkmxPVUh|ryP NFjCW|RUSU6JRWK=
OAW-42 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGGyZnJKSzVyPUSwMlQzPThizszN NITkOFdUSU6JRWK=
JVM-2 NUHGe41VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37ZcGlEPTB;NEGuNlQyPSEQvF2= MVTTRW5ITVJ?
C3A NE\adVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LhS2lEPTB;NEGuN|Q1PyEQvF2= NW\MdXY1W0GQR1XS
HT55 NX7VZZlkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfLVY5pUUN3ME20Nk4zQDRzIN88US=> MW\TRW5ITVJ?
OVCAR-4 NUGwdGR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\OTWM2OD12Mj6yPVc1KM7:TR?= MmnvV2FPT0WU
MEG-01 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnOyTWM2OD12Mj60OlE3KM7:TR?= MUXTRW5ITVJ?
NCI-H82 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVX3cGNrUUN3ME20N{46QDl{IN88US=> Mlm0V2FPT0WU
JEG-3 NUPSO3MxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTqeJVKSzVyPUS0Mlk1PyEQvF2= NFi5V4lUSU6JRWK=
BPH-1 NH3m[WtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPMUGluUUN3ME20Ok4{QTl6IN88US=> M3jnSHNCVkeHUh?=
MPP-89 M2LxPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1q3ZWlEPTB;NEeuNlg6QCEQvF2= NHHIZ2JUSU6JRWK=
ALL-PO NHT3WZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;GTWM2OD12Nz60NVg5KM7:TR?= MlTpV2FPT0WU
HT M{m3d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\MfJNKSzVyPUS3MlQ6OiEQvF2= MVXTRW5ITVJ?
NCI-H2347 Mn\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M373[2lEPTB;NEiuNFcyPSEQvF2= Mn3NV2FPT0WU
A2780 MlTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjWOGRKSzVyPUS5MlQzOjhizszN MYTTRW5ITVJ?
KARPAS-299 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\G[2ZLUUN3ME20PU42OTF7IN88US=> NX34bHZxW0GQR1XS
NCI-H1651 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fTeGlEPTB;NEmuPFgzOSEQvF2= NYS1WHlVW0GQR1XS

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
RB1 (pT821) / RB1 (pS780) / RB1 / CDK6 / CCND2 / RUNX1 / ETO; 

PubMed: 30300583     


Immunoblots showing dose-dependent impact of 72 hr palbociclib treatment on indicated protein levels in Kasumi-1 and SKNO-1 cells.

pRb(S807, 811) / CDK4 / CDK6 / PARP; 

PubMed: 28453226     


Effects of palbociclib on CDK4/6-Rb pathway. HCC cells were treated with different doses of palbociclib for 24 h, and then, the cells were subjected to western blot analysis. CF, cleaved fragment. 

LC3-I / LC3-II; 

PubMed: 28453226     


Palbociclib increases LC3-II amount in a dose-dependent manner in HCC cell lines. 

pAMPKα(T172) / pULK1(S317); 

PubMed: 28453226     


Dose-dependent response of palbociclib on AMPK-related molecules. HCC cells were treated with different concentrations of palbociclib for 24 h. The phosphorylation of the indicated proteins was determined by western blotting. 

SMAD2 (pS255); 

PubMed: 30343527     


T47D cells were treated with indicated concentrations of palbociclib for 24 h to evaluate substrate phosphorylation.

30300583 28453226 30343527
Growth inhibition assay
Cell viability; 

PubMed: 29670090     


Cell viability was determined by MTT assays after palbociclib exposure for 2, 4, and 6 days. The cell cycle of SYO-1 and Fuji cells was assessed after exposure to palbociclib (1 µM) for 24 h by flow cytometry analysis.

29670090
Immunofluorescence
SAHF/ATRX; 

PubMed: 26988987     


DAPI staining for senescence-associated heterochromatic foci (SAHF, left panel) and ATRX staining (right panel) in 1205Lu cells +/− palbociclib for 8 days. 

LC3B; 

PubMed: 28453226     


LC3B immunofluorescence in palbociclib‐treated Hep3B cells. Arrowheads indicate LC3-positive autophagosomes. Nuclei were counterstained with DAPI (blue).

26988987 28453226
ELISA
PGE2; 

PubMed: 26540629     


The supernatant of control and 7.5 μM palbociclib-treated cells was collected and stored at −80°C. PGE2 secretion was detected using ELISA.

26540629
体内研究 150 mg/kg PD 0332991处理 MDA-MB-435移植瘤完全抑制肿瘤。在多种人类肿瘤移植瘤中,PD 0332991也显示广谱抗癌活性,通过除去血管中p-Rb和增殖Marker Ki-67,且调节基因使其处于E2F转录水平控制。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

- 合并

Cdk实验:

PD0332991溶解在DMSO中。在96孔板上进行CDK 实验。通过杆状病毒感染,所有的CDK-cyclin 激酶复合体 在昆虫细胞中表达。实验底物为与GST融合的一段pRb。每孔体积为0.1 ml,包含:终浓度为20 mm Tris-HCl(pH 为7.4), 50 mmNaCl, 1 mm二硫苏糖醇, 10 mmMgCl2, 25 μm ATP (用于CDK4-cyclin D1, CDK6-cyclin D2,和CDK6-cyclin D3)或12 μm ATP (用于CDK2-cyclin E, CDK2-cyclin A, 和CDC2-cyclin B),0.25 μCi [γ-32P]ATP, 20 ng 酶, 1 μg GST·RB-Cterm, 及PD 0332991 (0.001-0.1μM)。除了[γ-32P]ATP的所有混合物加到孔中,放在搅拌器上搅拌2分钟。加入 [γ-32P]ATP开始反应, 在25 oC下温育15分钟。加入0.1 ml 20% 三氯乙酸终止反应, 在4 oC维持至少1小时,使底物沉淀。用0.2 ml 10%三氯乙酸冲洗5次,用β-计数器板测定掺入的放射性。
细胞实验:

[1]

- 合并
  • Cell lines: MDA-MB-435, ZR-75-1, T-47D, MCF-7, H1299, Colo-205, MDA-MB-468, H2009, CRRF-CEM,和K562细胞
  • Concentrations: 0.01-1 μM
  • Incubation Time: 24小时
  • Method:

    肿瘤细胞包括MDA-MB-435, ZR-75-1, T-47D, MCF-7, H1299, Colo-205, MDA-MB-468, H2009, CRRF-CEM,及K562按每孔2×104个细胞接种在96孔板上,温育过夜。加入PD 0332991 (0.01-1 μM) ,37oC温育24小时。每孔加入[14C]胸甘(0.1 μCi) ,进行同位素示踪,持续72小时。用β-计数器板测定掺入的放射性。


    (Only for Reference)
动物实验:

[1]

- 合并
  • Animal Models: 携带晚期人类肿瘤移植瘤,包括结肠-205, MDA-MB-435 乳腺癌, SF-295 恶性胶质瘤, ZR-75-1 乳腺癌, PC-3 前列腺癌, H125 肺癌, SW-620结肠癌, H23肺癌,及MDA-MB-468 乳腺癌 (Rb 阴性)的SCID鼠
  • Dosages: 0-150 mg/kg
  • Administration: 口服饲喂
    (Only for Reference)

溶解度 (25°C)

体外 Water 30 mg/mL (61.98 mM)
DMSO 3 mg/mL warmed (6.19 mM)
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
Saline
6 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 483.99
化学式

C24H29N7O2.HCl

CAS号 827022-32-2
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04360941 Not yet recruiting Drug: Palbociclib|Drug: Avelumab Triple Negative Breast Cancer|Locally Advanced Breast Cancer|Recurrent Breast Cancer|Metastatic Breast Cancer|ER+ Breast Cancer|HER2-positive Breast Cancer Royal Marsden NHS Foundation Trust|Pfizer|Breast Cancer Now July 1 2020 Phase 1
NCT03870919 Suspended Drug: Palbociclib|Other: locoregional treatment Breast Cancer Stage IV|Radiotherapy|Surgery UNICANCER|Pfizer October 23 2019 Not Applicable
NCT03900884 Not yet recruiting Drug: Venetoclax|Drug: Palbociclib|Drug: Letrozole Breast Neoplasm Female Peter MacCallum Cancer Centre Australia September 2019 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID