Palbociclib (PD-0332991) HCl

Pfizer辉瑞授权 目录号:S1116

Palbociclib (PD-0332991) HCl Chemical Structure

Molecular Weight(MW): 483.99

Palbociclib (PD-0332991) HCl是一种高度选择性的CDK4/6抑制剂,无细胞试验中IC50分别为11 nM/16 nM。它对CDK1/2/5,EGFR,FGFR,PDGFR,InsR等没有抑制活性。Phase 3。

规格 价格 库存 购买数量  
RMB 902.49 现货
RMB 1406.17 现货
RMB 4670.26 现货
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客户使用Selleck该产品发表文献26篇:

产品安全说明书

CDK抑制剂选择性比较

生物活性

产品描述 Palbociclib (PD-0332991) HCl是一种高度选择性的CDK4/6抑制剂,无细胞试验中IC50分别为11 nM/16 nM。它对CDK1/2/5,EGFR,FGFR,PDGFR,InsR等没有抑制活性。Phase 3。
特性 PD-0332991作为有应用前景的工具测定CDK激酶是否具有明显的治疗价值。
靶点
CDK4/CyclinD3 [1]
(Cell-free assay)
CDK4/CyclinD1 [1]
(Cell-free assay)
CDK6/CyclinD2 [1]
(Cell-free assay)
9 nM 11 nM 15 nM
体外研究

PD 0332991 对其他蛋白激酶包括EGFR, FGFR, PGFR, IR等没有抑制效果。 PD 0332991作用于Cdk4时是非ATP竞争性抑制剂。PD 0332991抑制MDA-MB-435乳腺癌细胞,IC50为66 nM,是由于Rb 在Ser780的磷酸化作用下降。PD 0332991抑制胸苷合并到Rb阳性的人类乳腺癌,结肠癌 肺癌,及白血病的DNA中,IC50值为4 nM到0.17 μM。PD 0332991作用于Rb阴性细胞没有抑制效果。PD 0332991作用于MDA-MB-453乳腺癌细胞和结肠-205细胞使细胞积累在G1期。[1]PD 0332991也有效作用于骨髓瘤5T33MM细胞,使细胞对Bortezomib敏感。[2]PD 0332991抑制luminalER-阳性和HER2-增强的乳腺癌细胞系,包括MDA-MB-175 ZR-75-30 CAMA-1 MDA-MB-134 HCC-202 UACC-893 等等。在这些细胞系中,PD 0332991增强Tamoxifen和Trastuzumab 的活性。在MCF7抗Tamoxifen细胞中,PD 0332991也增强tamoxifen 的敏感性。[3] 最新研究显示PD 0332991可以抑制恶性横纹肌样肿瘤(MRT)细胞系包括MP-MRT-AN, KP-MRT-RY, G401, KP-MRT-NS,且MRT细胞系对PD 0332991敏感性和p16表达呈负相关。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MOLM13 MlXTT4lv[XOnIFHzd4F6 NHXUdZIzPCCq NV7FU4h3UW6qaXLpeIlwdiCxZjDDSGs1KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhWmJicHjvd5Bpd3K7bHH0bY9vKHerdHigTWM2OCCxZjCwMlAxOiEQvF2= M4HyfFI1PjRzMUCz
COLO205 NIDDWm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXNRWdLPzJiaB?= NUDYWlZ4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|ZYPz[YQh[XNiaX7jc5Jxd3KjdHnvckBw\iCdM1jdeIh6dWmmaX7lJIlvfG9iRF7BJJdqfGhiSVO1NEBw\iByLkCzOkDPxE1? NUfLUIdROjR4NEGxNFM>
U937 MljTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXFTIttPzJiaB?= M4rWU2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2W|c3XkJIF{KGmwY3;ydI9z[XSrb36gc4YhYzOKXYTofY1q\GmwZTDpcpRwKESQQTD3bZRpKEmFNUCgc4YhOC5zNDFOwG0> Ml7PNlQ3PDFzMEO=
MOLM13 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUC3NkBp MkPLRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPT1zNNVMh[2WubIOgbIFz[m:{aX7nJGZNXDNiSWTEJI12fGGwdDDhd5Nme3OnZDDhd{BqdmOxcoDvdoF1cW:wIH;mJHs{UF22aIntbYRqdmViaX70c{BFVkFid3n0bEBKSzVyIH;mJFAvODl4IN88US=> M{LkSFI1PjRzMUCz
MOLM13 NHf6WFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWC3NkBp MV3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IIPvdoFn\W6rYj3y[ZNqe3SjboSgbJVu[W5iTV;MUVE{KGOnbHzzJIF{e2W|c3XkJIF{KGmwY3;ydI9z[XSrb36gc4YhYzOKXYTofY1q\GmwZTDpcpRwKESQQTD3bZRpKEmFNUCgc4YhOC5yOU[g{txO NVix[os2OjR4NEGxNFM>
MDA-MB-435 NGPBSIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPWTIQzPCCq NIK0[WZKSzVyPUCuNVYh|ryP M{HvT|E2QDBzOEOx
K562 MUfDfZRwfG:6aXOgRZN{[Xl? M3;Tclk3KGh? MXLEUXNQ M2LpTGlEPTB;MjFOwG0> NXLEd|VGOjR2MUe1OlY>
DU145 NYXB[5UzS3m2b4TvfIlkKEG|c3H5 MlXWPVYhcA>? NXOyZZA4TE2VTx?= MXzJR|UxRTdwNTFOwG0> MXiyOFQyPzV4Nh?=
MDA-MB-231 M4HSdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYexJO69VQ>? NWHOToJJOjRiaB?= MWjEUXNQ M{L5OGNmdGxiY4njcIUh[XK{ZYP0JIF{e2W|c3XkJIF{KGGlY4XteYxifGmxbjDheEBIOSCyaHHz[S=> MlLENlQ1OTd3Nk[=
MCF7 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUexJO69VQ>? NUjyUpdHOjRiaB?= MVfEUXNQ NVjvW2dJS2WubDDjfYNt\SCjcoLld5Qh[XO|ZYPz[YQh[XNiYXPjeY12dGG2aX;uJIF1KEdzIIDoZZNm MXGyOFQyPzV4Nh?=
MCF7 NIrENZpMcW6jc3WgRZN{[Xl? MYm1JO69VQ>? M1mzNlI1KGh? MlTjSG1UVw>? NUHjOZNQUW6qaXLpeIlwdiCxZjDy[YNwdWKrbnHueEBETEt2L3P5Z4xqdkRzIHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZicnX0bY5w[myjc4TvcYEheGixc4Doc5J6dGG2aX;uJIF1KFOncke4NC=> NXfGfWp{OjR2MUe1OlY>
MDA-MB-231 MXfLbY5ie2ViQYPzZZk> NUDqbJJzPSEQvF2= MWOyOEBp MV7EUXNQ MWLJcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IFPET|Qw[3mlbHnuSFEh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBz\XSrbn;icIF{fG:vYTDwbI9{eGixconsZZRqd25iYYSgV4VzPzhy MWCyOFQyPzV4Nh?=
MDA-MB-231 NX\Lc4tqTnWwY4Tpc44hSXO|YYm= NVXHcI1COS1zMDFOwG0> NV34e3pqOjRiaB?= M{LqS2ROW09? MXHkc4V{KG6xdDDpcoR2[2ViYYDvdJRwe2m|IHHzd4V{e2WmIHHzJHBCWlBiY3zlZZZi\2V? NHzUNZkzPDRzN{W2Oi=>
MCF7 MYDGeY5kfGmxbjDBd5NigQ>? MWCxMVExKM7:TR?= M13JNFI1KGh? MonCSG1UVw>? M2PSOoRw\XNibn;0JIlv\HWlZTDhdI9xfG:|aYOgZZN{\XO|ZXSgZZMhWEGUUDDjcIVifmGpZR?= MV2yOFQyPzV4Nh?=
MDA-MB-231 MVnGeY5kfGmxbjDBd5NigQ>? NHX3OIMxNjVvMTFOwG0> NFvEXpc1QCCq M3r0T2ROW09? NHG4S2pp[XNibn:gR4VtdCCleXPs[UBienKnc4SgZZN{\XO|ZXSgZZMh[WOldX31cIF1cW:wIHH0JJN2[i2JMTDwbIF{\Q>? NWX2SlFSOjR2MUe1OlY>
MCF7 NYHVO3l6TnWwY4Tpc44hSXO|YYm= NVLwUYdrOC53LUGg{txO M3;5clQ5KGh? NV3qe|RzTE2VTx?= NI\KSGRp[XNibn:gR4VtdCCleXPs[UBienKnc4SgZZN{\XO|ZXSgZZMh[WOldX31cIF1cW:wIHH0JJN2[i2JMTDwbIF{\Q>? NULmSWpEOjR2MUe1OlY>
697 NGLaXINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTF2OD6zPEBvVQ>? MVnTRW5ITVJ?
P12-ICHIKAWA NHG3TFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULuU3R4UUN3ME25Ok4xPCCwTR?= NHPtb3RUSU6JRWK=
NB69 NX3jflBzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrjTWM2OD1zNkGuPEBvVQ>? NHHhN2NUSU6JRWK=
EoL-1 NGjYZW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHL0[3BKSzVyPUG4O{4zPiCwTR?= MXXTRW5ITVJ?
BHT-101 Mly5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYS3dZVPUUN3ME2xPVgvOjVibl2= Ml:xV2FPT0WU
SK-NEP-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3idFJKSzVyPUKyNE4xOiCwTR?= M1TTNXNCVkeHUh?=
MHH-NB-11 M4PBe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFS2UGlKSzVyPUKyNE4yQSCwTR?= M3HUWnNCVkeHUh?=
AsPC-1 NX\lRZltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTJ3Mj61N{BvVQ>? MmDkV2FPT0WU
ES1 MnzzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnScXRTUUN3ME2yOVYvOjVibl2= M13vUnNCVkeHUh?=
LAMA-84 Ml;pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLxTWM2OD1{NUiuNVkhdk1? M{HqXnNCVkeHUh?=
MOLT-16 MkC1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPyUYN2UUN3ME2yOVgvPDlibl2= MV\TRW5ITVJ?
ES7 M2LUS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;sTWM2OD1{N{OuNFkhdk1? NVzv[2d6W0GQR1XS
KY821 NYLQcGh7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH36OGxKSzVyPUOxOE4yKG6P NEfBWGxUSU6JRWK=
RT-112 NH3aW|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfPTWM2OD1|MkGuNFUhdk1? M4\BbnNCVkeHUh?=
HL-60 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTN2MD62OkBvVQ>? NVrnWXpzW0GQR1XS
MOLT-4 NEPiWVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXyxeIZuUUN3ME2zOFUvOTNibl2= MYPTRW5ITVJ?
KARPAS-45 NYDhboxET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTN5Nj6xOkBvVQ>? M1PzfHNCVkeHUh?=
SK-N-AS M4Ptc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYr5TnZ4UUN3ME2zPFcvQDNibl2= Ml7CV2FPT0WU
CTB-1 NEjk[XdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTRyNT6wNkBvVQ>? NH3HU4lUSU6JRWK=
NKM-1 NGS1WppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXlTWM2OD12MUGuPFkhdk1? MU\TRW5ITVJ?
HTC-C3 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXqTWM2OD12M{KuPVUhdk1? M4qyWXNCVkeHUh?=
BE-13 MlW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPhTWM2OD12NESuNlchdk1? M3fhU3NCVkeHUh?=
KOSC-2 NGrscVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfOTWM2OD12Nk[uPUBvVQ>? MkmxV2FPT0WU
NB14 NYexTXdxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHONmhKSzVyPUS4N{42QCCwTR?= NGHpTWZUSU6JRWK=
CAL-27 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;aNmFmUUN3ME20PVQvPTlibl2= M3;sXXNCVkeHUh?=
H9 NWTYXoJnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mle5TWM2OD12OUWuOFMhdk1? NVz5c5piW0GQR1XS
RS4-11 NHHhcI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrZNWZJUUN3ME21NFQvPzNibl2= NIXGXWxUSU6JRWK=
PA-1 NV3LUXN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHezRlNKSzVyPUWwPU45PiCwTR?= NULUdmdMW0GQR1XS
MV-4-11 Ml36S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTVzMz64OUBvVQ>? NGjO[GhUSU6JRWK=
OS-RC-2 Ml\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDyU2dMUUN3ME21NlEvPjJibl2= NUTObHg3W0GQR1XS
RPMI-8226 NEK1NYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTV{Nj64OkBvVQ>? M4m0b3NCVkeHUh?=
HGC-27 NXXQ[|NyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTV4ND65PUBvVQ>? NU\FT5VuW0GQR1XS
CHP-212 M3rkfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjIcXY4UUN3ME21PVMvPTlibl2= NVjhRmkyW0GQR1XS
NB10 MlHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXEXmxKSzVyPUW5PU4yQCCwTR?= NWHEcFk2W0GQR1XS
HH NXTDeGdpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XXZ2lEPTB;NUm5MlQ{KG6P NF7DWFBUSU6JRWK=
EW-16 NWjoV|ZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXzS3VKSzVyPU[wN{42OiCwTR?= M{m1ZnNCVkeHUh?=
ES8 NVzubm94T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfhO4huUUN3ME22NFUvOjFibl2= NEnud3hUSU6JRWK=
HAL-01 MnS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfiR5RKSzVyPU[wOU43PyCwTR?= M{nwSXNCVkeHUh?=
A204 NH\2c3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7ZbIRTUUN3ME22N|MvQTFibl2= NH24UVhUSU6JRWK=
MHH-PREB-1 NWjGelI5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;USGZKSzVyPU[zOk46QSCwTR?= NYrW[pdRW0GQR1XS
EM-2 NGnDdmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTZ3MD62OEBvVQ>? M3n2OHNCVkeHUh?=
BV-173 NVnEUWhET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrmUlVKSzVyPU[1Nk41QCCwTR?= MYXTRW5ITVJ?
ONS-76 NVPqV49pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn2wTWM2OD14N{euPFIhdk1? NGXX[lRUSU6JRWK=
KM-H2 MnnuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTZ7NT61OEBvVQ>? NWHMTpNXW0GQR1XS
D-263MG M1fZXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHUdlFKSzVyPUexO{4yOiCwTR?= M33CWHNCVkeHUh?=
ES3 NV;lb|A{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDGcZRKSzVyPUeyPE46OyCwTR?= MV7TRW5ITVJ?
VA-ES-BJ NWPscFF7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFGyZlBKSzVyPUezNk4zPyCwTR?= MXLTRW5ITVJ?
NBsusSR NHzObYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2WzZ2lEPTB;N{SyMlk6KG6P MkX2V2FPT0WU
NCI-H520 M33zVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjjelFHUUN3ME23OFYvPTJibl2= MX3TRW5ITVJ?
ES5 MlS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2q5cGlEPTB;N{WyMlghdk1? NED2V|FUSU6JRWK=
T-24 NUT4UXZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHz5SYtKSzVyPUe3PE44OSCwTR?= MVrTRW5ITVJ?
SW962 NVfQTpBQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfacVd6UUN3ME24NFgvPjNibl2= NFvjRXZUSU6JRWK=
EW-3 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV76dWZvUUN3ME24NFgvPzZibl2= MkT3V2FPT0WU
RXF393 NH7ucIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XQOGlEPTB;OEGyMlc6KG6P MX3TRW5ITVJ?
U251 NFfJfJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLTTWM2OD16MUOuPFghdk1? M{fRd3NCVkeHUh?=
CAMA-1 M4P2TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfCPVBtUUN3ME24N|MvQTRibl2= NUHQcm1IW0GQR1XS
JVM-3 NH3JWWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTh3MT63PEBvVQ>? NIHMS4NUSU6JRWK=
COLO-800 M4S0U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTh7Nz63PEBvVQ>? MlfyV2FPT0WU
OVCAR-5 MojDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DaWmlEPTB;OUCwMlEhdk1? NEPMZoVUSU6JRWK=
LB1047-RCC M3fqWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYP5UVRKUUN3ME25NlcvPTZibl2= NHvmPXFUSU6JRWK=
SW954 Ml33S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWGwfoJHUUN3ME25NlkvPDFibl2= NETreplUSU6JRWK=
J-RT3-T3-5 MnG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfpSXR4UUN3ME25N|YvODZibl2= MljyV2FPT0WU
Mewo NV;jbm1CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnywTWM2OD17M{[uOkBvVQ>? NIjYfJlUSU6JRWK=
NCI-H1770 NFzYdZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXntWJBYUUN3ME25OFAvPTVibl2= NWT3b2hQW0GQR1XS
HO-1-N-1 NHnGemZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jXXWlEPTB;OU[yMlgyKG6P NVm1cFFbW0GQR1XS
HSC-3 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPKfZhKSzVyPUm2Ok41QCCwTR?= NWjaUVB4W0GQR1XS
TYK-nu MkDIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHxV|VKSzVyPUm5PE4zPSCwTR?= NYf4elJqW0GQR1XS
KYSE-150 M2\TfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjjTWM2OD1zLkCwNFc3KM7:TR?= NWfm[VM{W0GQR1XS
SN12C MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXzWVBKSzVyPUGuNFA5PzVizszN M3TYXXNCVkeHUh?=
MOLT-13 M37QWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkC5TWM2OD1zLkCxOFIyKM7:TR?= NU[1eGhoW0GQR1XS
TE-11 M4S3S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTFwMES4NVIh|ryP Mn3pV2FPT0WU
DB M1O0Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFn4N3hKSzVyPUGuNFczPzNizszN NEi5cHVUSU6JRWK=
CAL-39 M4i3W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37RSWlEPTB;MT6wO|UzOiEQvF2= MlPjV2FPT0WU
A3-KAW M4LwZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTFwMEi0NFgh|ryP Mm\IV2FPT0WU
CHP-134 M2rFcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHOdHVKSzVyPUGuNVE5ODdizszN NGDjN5lUSU6JRWK=
TGW NVW3dIUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFz2NmtKSzVyPUGuNVI{QTVizszN MYXTRW5ITVJ?
QIMR-WIL MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDDcppKSzVyPUGuNVMyOzRizszN NWjydIJpW0GQR1XS
NCI-SNU-1 NFWxdY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnpTWM2OD1zLkG2N|U1KM7:TR?= M2PsU3NCVkeHUh?=
CGTH-W-1 MlLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjRTWM2OD1zLkG3NVg3KM7:TR?= NITzU21USU6JRWK=
MHH-ES-1 NI\Qc3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{L6fWlEPTB;MT6xO|k5PiEQvF2= NGnhbFNUSU6JRWK=
LB2241-RCC MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHQTWM2OD1zLkG4OlIh|ryP M2nybHNCVkeHUh?=
ML-2 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTFwMkC3N|Qh|ryP MmjuV2FPT0WU
COR-L23 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTFwMkK5N|Mh|ryP MVnTRW5ITVJ?
BFTC-905 MnfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fLSWlEPTB;MT6yOFI3PyEQvF2= NVPrPIRvW0GQR1XS
Hs-578-T MmX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTFwMkW4NVch|ryP MoTWV2FPT0WU
KG-1 NHrRPVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrl[XRKSzVyPUGuNlY3QDZizszN MlzhV2FPT0WU
HEL Mmq1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHMWIhKSzVyPUGuNlk{OzhizszN MUHTRW5ITVJ?
A549 MkjLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXPZnRoUUN3ME2xMlI6Ozl7IN88US=> MorLV2FPT0WU
COLO-741 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfvTWpKSzVyPUGuN|IxQDlizszN MlzqV2FPT0WU
PC-3 MlnkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnoWIVKSzVyPUGuN|UzOjFizszN NXWzU5A6W0GQR1XS
HOS MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M16zbGlEPTB;MT6zOVI6PiEQvF2= NVq2VIRtW0GQR1XS
HT-1080 NGXwb4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHiVlVtUUN3ME2xMlM4PTF7IN88US=> MXLTRW5ITVJ?
TE-8 Mn34S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTFwNEG3O|Qh|ryP NHnQ[XhUSU6JRWK=
BHY M1iwe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{H4d2lEPTB;MT60OlkzOyEQvF2= M3HQNXNCVkeHUh?=
BB65-RCC MoWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;kdWlEPTB;MT61NFUzQCEQvF2= NFOxR3RUSU6JRWK=
HN MmrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\CboJRUUN3ME2xMlU1ODdzIN88US=> NEDmcpdUSU6JRWK=
NCI-H441 NHG4T5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTFwNUS5NFch|ryP NFLyU4VUSU6JRWK=
RPMI-8866 MniyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTFwNUi1NFch|ryP M3HZ[3NCVkeHUh?=
CAL-62 MnrPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjmSYZKSzVyPUGuOlA5PjJizszN MYXTRW5ITVJ?
MG-63 NHvHWFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\XbHdtUUN3ME2xMlYyQDF|IN88US=> NVr4S5l7W0GQR1XS
SK-LU-1 NX\zO3Z4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWH6WY92UUN3ME2xMlYzOTV{IN88US=> NV3JUVNNW0GQR1XS
BCPAP MlLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTFwNk[0OVch|ryP NH;wepVUSU6JRWK=
22RV1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\pZ5dKSzVyPUGuOlc5PDNizszN NXftc3g6W0GQR1XS
T47D NVW4O2ZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rKTmlEPTB;MT62PFA3OSEQvF2= M{\6SnNCVkeHUh?=
MSTO-211H Mnf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWr0UmJOUUN3ME2xMlY6PjB|IN88US=> M3\OPXNCVkeHUh?=
DEL NVuzNmhtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTFwN{CyO|Mh|ryP NFjUT4ZUSU6JRWK=
H4 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXvSJNKSzVyPUGuO|MzOTJizszN Mn[zV2FPT0WU
CAL-51 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFGxNYZKSzVyPUGuO|Q5PTVizszN MVLTRW5ITVJ?
ABC-1 NF;wVpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnK3TWM2OD1zLke4OVgzKM7:TR?= M3jJfXNCVkeHUh?=
MZ2-MEL M4TuZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTFwN{m1OFIh|ryP M3TvXXNCVkeHUh?=
YKG-1 MoL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnkc2dKSzVyPUGuPFExPjFizszN MXHTRW5ITVJ?
KM12 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvOZ2pqUUN3ME2xMlgyPjB{IN88US=> NEj4cJNUSU6JRWK=
L-363 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17CXmlEPTB;MT64O|QyOiEQvF2= NYrrflVTW0GQR1XS
KU812 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nwUGlEPTB;MT64PVI5OiEQvF2= NFK4TlFUSU6JRWK=
LOXIMVI MlHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;3TWM2OD1zLkmxNlI5KM7:TR?= NHn0bm1USU6JRWK=
G-401 NEDBb3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFX4VIZKSzVyPUGuPVI1OjhizszN NYP3UFlVW0GQR1XS
SW780 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvRTWM2OD1zLkm2NlQ3KM7:TR?= MofhV2FPT0WU
SW872 NXrpWo9QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTFwOUizN{DPxE1? M2jNWHNCVkeHUh?=
NB7 MlrVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHrbGV6UUN3ME2xMlk6OzJ|IN88US=> NYTTcnVGW0GQR1XS
T98G NHrp[Y9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvlTWM2OD1{LkCwOlY3KM7:TR?= NEXuRoNUSU6JRWK=
SW1710 NVrPT3VOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;lVmlEPTB;Mj6wOlk1PSEQvF2= NFrzR5FUSU6JRWK=
NCI-H1573 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTJwMEeyPVgh|ryP MYLTRW5ITVJ?
KE-37 NUnNU|JzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLFXlUzUUN3ME2yMlA5QTVzIN88US=> MVfTRW5ITVJ?
786-0 MnGxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLu[oZKSzVyPUKuNVU1OzlizszN MYrTRW5ITVJ?
SAS Mn;2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDHTG9KSzVyPUKuNlA{PzRizszN NWrI[2dTW0GQR1XS
CAL-54 M3jDXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYOxSZZbUUN3ME2yMlIxPDF|IN88US=> Mk\sV2FPT0WU
SF268 M2XPOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\CW4hKSzVyPUKuNlMyOjJizszN NI[2[GlUSU6JRWK=
SW620 NULsTlI6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfEZXRKSzVyPUKuNlYyPjlizszN MoK5V2FPT0WU
MN-60 NFPxNldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTJwM{GwOkDPxE1? NFH4VJBUSU6JRWK=
EFO-27 M2fTNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLCU3ZKSzVyPUKuN|IxPThizszN NFu1WFZUSU6JRWK=
NCI-H747 M2TjR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYL0d4dSUUN3ME2yMlMzOTl7IN88US=> MkKwV2FPT0WU
HCC2218 M1ixWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnrcmNKSzVyPUKuN|U{PzRizszN Ml\OV2FPT0WU
MIA-PaCa-2 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3Hh[2lEPTB;Mj6zOlQ{PyEQvF2= NX\3c2Q3W0GQR1XS
SJSA-1 NHX2TXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTJwM{e3PVYh|ryP M3f6TXNCVkeHUh?=
RKO NEDLXlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGr4dpZKSzVyPUKuN|g1QTZizszN NHq0UI9USU6JRWK=
NB6 MnH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXThVmdxUUN3ME2yMlQxOzd2IN88US=> M3LRVHNCVkeHUh?=
ES4 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2S0WGlEPTB;Mj60OVQzOiEQvF2= MoP1V2FPT0WU
EGI-1 NXzn[Jl[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvob5RKSzVyPUKuOFY5QDNizszN NV;XVJpIW0GQR1XS
CTV-1 M2\IdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTJwNUK3O|Mh|ryP NF:yT5hUSU6JRWK=
NCI-H1355 NH\JfnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI[5VllKSzVyPUKuOVU6PTFizszN MoPLV2FPT0WU
GT3TKB NVz1fVBCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTJwNUmxPVkh|ryP MXXTRW5ITVJ?
SK-HEP-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWO4U|ZrUUN3ME2yMlU6OjZ4IN88US=> M3zWTXNCVkeHUh?=
GAMG Mn3BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\zeGlEPTB;Mj61PVM6PCEQvF2= MX\TRW5ITVJ?
SK-MES-1 Mn\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PscWlEPTB;Mj62NVgxOyEQvF2= MUjTRW5ITVJ?
RO82-W-1 NXKxS5A2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTJwNkKwOVch|ryP NV;PO3lxW0GQR1XS
ECC10 NITFUlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjzNItIUUN3ME2yMlcxOjB4IN88US=> MUXTRW5ITVJ?
MCF7 MnP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfuTWM2OD1{LkexOFY1KM7:TR?= M{nmenNCVkeHUh?=
D-283MED MoLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlL4TWM2OD1{LkeyOFMh|ryP NHi3SWVUSU6JRWK=
RPMI-7951 NFnWT3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEG0dlFKSzVyPUKuO|U3QTRizszN NFvFU|lUSU6JRWK=
Ramos-2G6-4C10 M1zoRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHlTWM2OD1{Lke3NFk6KM7:TR?= M4fBfnNCVkeHUh?=
KGN NF;sPFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{T0VGlEPTB;Mj64NVg5PCEQvF2= MmHnV2FPT0WU
NUGC-3 NX3UbmhtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTJwOEK1NFUh|ryP MYnTRW5ITVJ?
NCI-H292 NHXRfVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzhRZNoUUN3ME2yMlg2ODV|IN88US=> M3H3cHNCVkeHUh?=
Becker NH7CTnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfZVGhyUUN3ME2yMlk2QDN{IN88US=> NX3VdWJ4W0GQR1XS
NCI-H1299 MnjCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nHPWlEPTB;Mz6wOVI3OyEQvF2= NXHabVFGW0GQR1XS
ETK-1 NITwe2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkn6TWM2OD1|LkC1OFMh|ryP NWq3S5U2W0GQR1XS
TK10 NEPJSolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWiyOlZvUUN3ME2zMlIxOTZ3IN88US=> MlPsV2FPT0WU
VMRC-RCZ MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTNwM{[0PFgh|ryP MmruV2FPT0WU
YH-13 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HrWmlEPTB;Mz60OFA4QSEQvF2= Ml3lV2FPT0WU
DU-145 NEfkR5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PD[WlEPTB;Mz60OlI3QSEQvF2= NHvobopUSU6JRWK=
SW1088 NGTMUZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPINoE5UUN3ME2zMlQ4PDdizszN NVHKcoE2W0GQR1XS
HOP-92 NFXuS5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTNwNUCzOFIh|ryP MWHTRW5ITVJ?
KP-N-YS NU\sNWlDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkL0TWM2OD1|Lk[yNVM6KM7:TR?= NWTmfWd[W0GQR1XS
NCI-H460 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7yTWM2OD1|Lk[2O|Mh|ryP MoXtV2FPT0WU
U-2-OS NHLXfIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnU[pVKSzVyPUOuO|I2OzVizszN NYrmbZlzW0GQR1XS
A101D MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TBe2lEPTB;Mz63Olk{PiEQvF2= MnW5V2FPT0WU
MDA-MB-231 NX2xd|dIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnmyTWM2OD1|LkixPVUyKM7:TR?= NXexUYs1W0GQR1XS
IST-MES1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fNR2lEPTB;Mz64N|Ih|ryP MoLEV2FPT0WU
COR-L105 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTRwMEG4JO69VQ>? NEjnR3BUSU6JRWK=
NCI-H1437 M{DycGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTRwMEKzNFIh|ryP MnvoV2FPT0WU
CAL-85-1 MmDLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTRwMEK0OlEh|ryP MU\TRW5ITVJ?
MZ1-PC MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3K2XWlEPTB;ND6xPFU2PiEQvF2= NFXpfWlUSU6JRWK=
VM-CUB-1 NHT6OG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXzVVhKSzVyPUSuN|EzQDRizszN MoXpV2FPT0WU
CHL-1 NXfyV4FST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3eyWWlEPTB;ND6zNlE3QSEQvF2= Ml7BV2FPT0WU
MDA-MB-361 NF;ISVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LRXWlEPTB;ND6zN|E2OyEQvF2= M4LDfHNCVkeHUh?=
NCI-H661 M{DoNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7Ifo9KSzVyPUSuOVAxQTJizszN M{DqWXNCVkeHUh?=
EW-11 NULPZnJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoC0TWM2OD12LkWyNlMyKM7:TR?= NH;aRotUSU6JRWK=
BEN MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HmU2lEPTB;ND61NlgyPSEQvF2= MXjTRW5ITVJ?
BFTC-909 Mkm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX:zeHZ6UUN3ME20MlU3Ojd3IN88US=> MkPNV2FPT0WU
NCI-H2087 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoL3TWM2OD12LkW4NVY1KM7:TR?= M{fWenNCVkeHUh?=
RVH-421 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTRwNk[2PUDPxE1? Mnv4V2FPT0WU
P30-OHK Ml62S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vqR2lEPTB;ND62PFAxQCEQvF2= MlvaV2FPT0WU
NCI-H28 NHH1VFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTRwOEG2OlEh|ryP MkCwV2FPT0WU
ES6 MlHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTRwOEOwNVYh|ryP MWfTRW5ITVJ?
769-P NWOySpNNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTRwOEW5NlYh|ryP NHn1SlhUSU6JRWK=
OE33 NFfBWnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3FTWM2OD12Lki4NVYyKM7:TR?= NFn5eJNUSU6JRWK=
SW982 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPyTWM2OD12Lkm1NFYyKM7:TR?= MWHTRW5ITVJ?
A388 Mkn6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG[w[WxKSzVyPUWuNFI6QDNizszN MWfTRW5ITVJ?
TI-73 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWGzcnVRUUN3ME21MlA3OTl2IN88US=> NI\4TnRUSU6JRWK=
HCT-116 M1jXXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDGcVdHUUN3ME21MlA6QDh7IN88US=> MmLXV2FPT0WU
HuP-T3 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2S1dWlEPTB;NT6xPFcxQSEQvF2= MX7TRW5ITVJ?
G-402 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;Ed|lKSzVyPUWuNVk1OTZizszN MmrpV2FPT0WU
NCI-H1792 NXzs[|kyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfmUJJqUUN3ME21MlI1PjJ{IN88US=> NV7BWFg4W0GQR1XS
NCI-H209 M1zzSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTVwMkW5OFIh|ryP NGHwT5pUSU6JRWK=
NCI-H1650 NEmybIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrieJpIUUN3ME21MlMxPjN2IN88US=> NIXwUYZUSU6JRWK=
LCLC-97TM1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTVwM{G4NFgh|ryP NHv2eFhUSU6JRWK=
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A427 M3PNc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DyN2lEPTB;MUiuOVA6PCEQvF2= M17XNXNCVkeHUh?=
HCC2998 NH[zeW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nvNmlEPTB;MUiuOlA2OSEQvF2= NI[0dldUSU6JRWK=
EPLC-272H NXu2[3V7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTF7LkC0N|Qh|ryP NFrZS3hUSU6JRWK=
C32 NUn6R4tET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4X6fmlEPTB;MUmuNFQ2KM7:TR?= NV3rWHdnW0GQR1XS
UMC-11 NFnBdnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTyNWVKSzVyPUG5MlIyOjNizszN NX7je4hJW0GQR1XS
CaR-1 MoXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnHe3RJUUN3ME2xPU43QDB2IN88US=> M{\5dHNCVkeHUh?=
KYSE-410 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4faT2lEPTB;MUmuPVE{QSEQvF2= MVTTRW5ITVJ?
HuCCT1 MmjxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTJyLk[yPVQh|ryP NUXnc2ZkW0GQR1XS
LB996-RCC MmXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LGcGlEPTB;MkCuO|E3QCEQvF2= NVPESGZjW0GQR1XS
KYSE-70 NH2wOJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljiTWM2OD1{MD64NFU6KM7:TR?= MmjKV2FPT0WU
CAL-72 M{K4RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnnSJlKSzVyPUKwMlkyPSEQvF2= MWLTRW5ITVJ?
Capan-2 M1zT[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1e3VGlEPTB;MkGuNFQyOyEQvF2= MkKyV2FPT0WU
PANC-08-13 M3\rbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojSTWM2OD1{MT6yOVE2KM7:TR?= M4G5RXNCVkeHUh?=
SBC-1 M1;sNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjVeWZKSzVyPUKxMlMxQDFizszN NVfK[YNqW0GQR1XS
MFM-223 M{PCVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrJfph{UUN3ME2yNU4{OzR{IN88US=> NW\uRoV7W0GQR1XS
BB49-HNC NGny[2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnhTWM2OD1{MT61O|E3KM7:TR?= MVrTRW5ITVJ?
SH-4 M4LK[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLWcIROUUN3ME2yNU43PjF6IN88US=> MlHWV2FPT0WU
HuO9 NHjWfmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTJzLkm4NlUh|ryP MWTTRW5ITVJ?
AM-38 MkfDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLVTWM2OD1{Mj6wOFg2KM7:TR?= M4L6S3NCVkeHUh?=
A431 NYf0NWxvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrSTWM2OD1{Mz6yNVE6KM7:TR?= NEmzflJUSU6JRWK=
YAPC MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPjTWM2OD1{Mz6yOlUyKM7:TR?= MWLTRW5ITVJ?
LU-139 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjWbWZuUUN3ME2yN{41QDB7IN88US=> NVj1RpM1W0GQR1XS
HEC-1 NFLLVXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUX4S4M5UUN3ME2yN{41QTN5IN88US=> MVfTRW5ITVJ?
SCC-25 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXSzOXJWUUN3ME2yOE4{ODB4IN88US=> M3HLXHNCVkeHUh?=
HT-29 NVKwUpR6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPYTWM2OD1{ND6zPFI{KM7:TR?= MWHTRW5ITVJ?
PC-14 M4n3RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLyTWM2OD1{ND62OVcyKM7:TR?= M4GxUHNCVkeHUh?=
Calu-6 NHLmTGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXOOlVKSzVyPUK1MlUxPzFizszN MUTTRW5ITVJ?
SJRH30 MorDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TiR2lEPTB;MkWuOlQ6PiEQvF2= NFTveWRUSU6JRWK=
ChaGo-K-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPobppIUUN3ME2yOk4yPjJ7IN88US=> M1HUZXNCVkeHUh?=
IA-LM MmjjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLQUZJKSzVyPUK2MlM3PDVizszN NYfVeHJqW0GQR1XS
GP5d NETuUIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTJ4LkS0PVEh|ryP MYfTRW5ITVJ?
NCI-H2291 NFnJ[I9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrZTWM2OD1{Nj62OVQyKM7:TR?= MVnTRW5ITVJ?
BALL-1 MlX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzab|NKSzVyPUK2Mlk{QTdizszN NEHiSJZUSU6JRWK=
HCC1954 MmfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXX2UIpnUUN3ME2yOk46QDB6IN88US=> MXLTRW5ITVJ?
NCI-H2452 NUfTXGo{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILoZpBKSzVyPUK3MlQyPjNizszN M2rqN3NCVkeHUh?=
LU-99A M1K0S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nuSWlEPTB;MkeuOVU5OiEQvF2= MXzTRW5ITVJ?
NTERA-S-cl-D1 MmDmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTJ5LkeyPVkh|ryP M3rKW3NCVkeHUh?=
PANC-10-05 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XVNmlEPTB;MkeuO|c4PSEQvF2= NH7nTHJUSU6JRWK=
NCI-H2405 M4KyfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\MSGlEPTB;MkeuPVM5PyEQvF2= NF;QWWRUSU6JRWK=
MDA-MB-415 NF74Oo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfDTWM2OD1{OD60NVM4KM7:TR?= NIfUcpNUSU6JRWK=
NCI-H2342 M3jBXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVq0SFBtUUN3ME2yPE42OjhzIN88US=> M2jxUXNCVkeHUh?=
TGBC24TKB NGLUXWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPDcGJKSzVyPUK4MlcyOTdizszN MXXTRW5ITVJ?
LU-134-A M2HqdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTJ6LkmyOlEh|ryP MX3TRW5ITVJ?
SCC-4 MmDjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfubmRLUUN3ME2zNU4xPDl2IN88US=> NGKwcJRUSU6JRWK=
Saos-2 NEL2TVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUL5bZlEUUN3ME2zNU46OzB4IN88US=> NX\kbZBlW0GQR1XS
RERF-LC-MS NW\3XHl2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17uNGlEPTB;M{KuPFI{OSEQvF2= MUjTRW5ITVJ?
M14 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvsT4JNUUN3ME2zNk46PzZ2IN88US=> MV7TRW5ITVJ?
HPAF-II MlfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTN|LkWwNVEh|ryP NGTnZ|JUSU6JRWK=
NCI-H1755 M1TxW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3u2SmlEPTB;M{SuN|MxPSEQvF2= NF\lRmhUSU6JRWK=
D-392MG NYK2UGRXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;pOoNQUUN3ME2zOU45Pjd2IN88US=> M2DkVnNCVkeHUh?=
A704 NWrjWFVTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjDWllKSzVyPUO2MlA1OjdizszN M3fzVnNCVkeHUh?=
CP50-MEL-B MofJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml:yTWM2OD1|Nj6xPVEyKM7:TR?= MnyxV2FPT0WU
EW-18 NIPyXXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn[5TWM2OD1|Nj60OVIh|ryP NF\NcnZUSU6JRWK=
WM-115 NUfLcIo5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFy3dXNKSzVyPUO2MlgxQTlizszN NF\wW29USU6JRWK=
LU-65 NIDsOoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPkc|BKSzVyPUO3MlE1OTdizszN NEHvUodUSU6JRWK=
NCI-H1563 NXLYRldPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfRTWM2OD1|Nz6yOFg1KM7:TR?= NYr3[FdRW0GQR1XS
DBTRG-05MG NVvaOGYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjXU3dKSzVyPUO4MlA3QTFizszN NYnyU4JEW0GQR1XS
NCI-H630 NGfN[FhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnCTWM2OD1|OD60O|E1KM7:TR?= MnPhV2FPT0WU
NCI-H1155 MnjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXzTWM2OD1|OT6yOFIh|ryP NXLqc|dRW0GQR1XS
OVACR-3 NVW4VY9oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXIbpJMUUN3ME2zPU46OTl3IN88US=> MU\TRW5ITVJ?
OAW-42 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\XRZdJUUN3ME20NE41OjV6IN88US=> M3;GXXNCVkeHUh?=
JVM-2 Ml\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTRzLkK0NVUh|ryP NHXTVZZUSU6JRWK=
C3A MoLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTRzLkO0OFch|ryP MVjTRW5ITVJ?
HT55 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13zVGlEPTB;NEKuNlg1OSEQvF2= NYPxTGRHW0GQR1XS
OVCAR-4 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPDTXVwUUN3ME20Nk4zQTd2IN88US=> NGXkTWRUSU6JRWK=
MEG-01 MnP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTXTWM2OD12Mj60OlE3KM7:TR?= MXHTRW5ITVJ?
NCI-H82 MoHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTR|Lkm4PVIh|ryP MnzOV2FPT0WU
JEG-3 NXvjZ45VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTR2Lkm0O{DPxE1? M{fENHNCVkeHUh?=
BPH-1 NIT5NnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPPUWlKSzVyPUS2MlM6QThizszN NYT6c|ZFW0GQR1XS
MPP-89 NGTxSYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LyZ2lEPTB;NEeuNlg6QCEQvF2= MV7TRW5ITVJ?
ALL-PO MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjpOm5KSzVyPUS3MlQyQDhizszN MUjTRW5ITVJ?
HT NIHFUFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvCTWM2OD12Nz60PVIh|ryP NWPaZZUxW0GQR1XS
NCI-H2347 M{CxT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzIWIxKSzVyPUS4MlA4OTVizszN NXjtcHp5W0GQR1XS
A2780 M{juSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfC[3dKSzVyPUS5MlQzOjhizszN MWXTRW5ITVJ?
KARPAS-299 Ml;vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\OTWlEPTB;NEmuOVEyQSEQvF2= NHnze2VUSU6JRWK=
NCI-H1651 MkXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HmOmlEPTB;NEmuPFgzOSEQvF2= NFvIbpRUSU6JRWK=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
RB1 (pT821) / RB1 (pS780) / RB1 / CDK6 / CCND2 / RUNX1 / ETO; 

PubMed: 30300583     


Immunoblots showing dose-dependent impact of 72 hr palbociclib treatment on indicated protein levels in Kasumi-1 and SKNO-1 cells.

pRb(S807, 811) / CDK4 / CDK6 / PARP; 

PubMed: 28453226     


Effects of palbociclib on CDK4/6-Rb pathway. HCC cells were treated with different doses of palbociclib for 24 h, and then, the cells were subjected to western blot analysis. CF, cleaved fragment. 

LC3-I / LC3-II; 

PubMed: 28453226     


Palbociclib increases LC3-II amount in a dose-dependent manner in HCC cell lines. 

pAMPKα(T172) / pULK1(S317); 

PubMed: 28453226     


Dose-dependent response of palbociclib on AMPK-related molecules. HCC cells were treated with different concentrations of palbociclib for 24 h. The phosphorylation of the indicated proteins was determined by western blotting. 

SMAD2 (pS255); 

PubMed: 30343527     


T47D cells were treated with indicated concentrations of palbociclib for 24 h to evaluate substrate phosphorylation.

30300583 28453226 30343527
Growth inhibition assay
Cell viability; 

PubMed: 29670090     


Cell viability was determined by MTT assays after palbociclib exposure for 2, 4, and 6 days. The cell cycle of SYO-1 and Fuji cells was assessed after exposure to palbociclib (1 µM) for 24 h by flow cytometry analysis.

29670090
Immunofluorescence
SAHF/ATRX; 

PubMed: 26988987     


DAPI staining for senescence-associated heterochromatic foci (SAHF, left panel) and ATRX staining (right panel) in 1205Lu cells +/− palbociclib for 8 days. 

LC3B; 

PubMed: 28453226     


LC3B immunofluorescence in palbociclib‐treated Hep3B cells. Arrowheads indicate LC3-positive autophagosomes. Nuclei were counterstained with DAPI (blue).

26988987 28453226
ELISA
PGE2; 

PubMed: 26540629     


The supernatant of control and 7.5 μM palbociclib-treated cells was collected and stored at −80°C. PGE2 secretion was detected using ELISA.

26540629
体内研究 150 mg/kg PD 0332991处理 MDA-MB-435移植瘤完全抑制肿瘤。在多种人类肿瘤移植瘤中,PD 0332991也显示广谱抗癌活性,通过除去血管中p-Rb和增殖Marker Ki-67,且调节基因使其处于E2F转录水平控制。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

+ 展开

Cdk实验:

PD0332991溶解在DMSO中。在96孔板上进行CDK 实验。通过杆状病毒感染,所有的CDK-cyclin 激酶复合体 在昆虫细胞中表达。实验底物为与GST融合的一段pRb。每孔体积为0.1 ml,包含:终浓度为20 mm Tris-HCl(pH 为7.4), 50 mmNaCl, 1 mm二硫苏糖醇, 10 mmMgCl2, 25 μm ATP (用于CDK4-cyclin D1, CDK6-cyclin D2,和CDK6-cyclin D3)或12 μm ATP (用于CDK2-cyclin E, CDK2-cyclin A, 和CDC2-cyclin B),0.25 μCi [γ-32P]ATP, 20 ng 酶, 1 μg GST·RB-Cterm, 及PD 0332991 (0.001-0.1μM)。除了[γ-32P]ATP的所有混合物加到孔中,放在搅拌器上搅拌2分钟。加入 [γ-32P]ATP开始反应, 在25 oC下温育15分钟。加入0.1 ml 20% 三氯乙酸终止反应, 在4 oC维持至少1小时,使底物沉淀。用0.2 ml 10%三氯乙酸冲洗5次,用β-计数器板测定掺入的放射性。
细胞实验:

[1]

+ 展开
  • Cell lines: MDA-MB-435, ZR-75-1, T-47D, MCF-7, H1299, Colo-205, MDA-MB-468, H2009, CRRF-CEM,和K562细胞
  • Concentrations: 0.01-1 μM
  • Incubation Time: 24小时
  • Method:

    肿瘤细胞包括MDA-MB-435, ZR-75-1, T-47D, MCF-7, H1299, Colo-205, MDA-MB-468, H2009, CRRF-CEM,及K562按每孔2×104个细胞接种在96孔板上,温育过夜。加入PD 0332991 (0.01-1 μM) ,37oC温育24小时。每孔加入[14C]胸甘(0.1 μCi) ,进行同位素示踪,持续72小时。用β-计数器板测定掺入的放射性。


    (Only for Reference)
动物实验:

[1]

+ 展开
  • Animal Models: 携带晚期人类肿瘤移植瘤,包括结肠-205, MDA-MB-435 乳腺癌, SF-295 恶性胶质瘤, ZR-75-1 乳腺癌, PC-3 前列腺癌, H125 肺癌, SW-620结肠癌, H23肺癌,及MDA-MB-468 乳腺癌 (Rb 阴性)的SCID鼠
  • Formulation: 溶解在乳酸钠buffer(50 mM, pH 4.0)中
  • Dosages: 0-150 mg/kg
  • Administration: 口服饲喂
    (Only for Reference)

溶解度 (25°C)

体外 Water 30 mg/mL (61.98 mM)
DMSO 3 mg/mL warmed (6.19 mM)
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
Saline
6 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 483.99
化学式

C24H29N7O2.HCl

CAS号 827022-32-2
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03870919 Not yet recruiting Breast Cancer Stage IV|Radiotherapy|Surgery UNICANCER|Pfizer May 15 2019 Not Applicable
NCT03870919 Not yet recruiting Breast Cancer Stage IV|Radiotherapy|Surgery UNICANCER|Pfizer May 15 2019 Not Applicable
NCT03820830 Not yet recruiting Breast Cancer Recurrent International Breast Cancer Study Group|Pfizer May 1 2019 Phase 3
NCT03820830 Not yet recruiting Breast Cancer Recurrent International Breast Cancer Study Group|Pfizer May 1 2019 Phase 3
NCT03609047 Not yet recruiting Breast Cancer Stage II|Breast Cancer Stage III European Organisation for Research and Treatment of Cancer - EORTC|Pfizer May 7 2019 Phase 2
NCT03609047 Not yet recruiting Breast Cancer Stage II|Breast Cancer Stage III European Organisation for Research and Treatment of Cancer - EORTC|Pfizer May 7 2019 Phase 2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID