Palbociclib (PD-0332991) HCl

Pfizer辉瑞授权 目录号:S1116

Palbociclib (PD-0332991) HCl Chemical Structure

Molecular Weight(MW): 483.99

Palbociclib (PD-0332991) HCl是一种高度选择性的CDK4/6抑制剂,无细胞试验中IC50分别为11 nM/16 nM。它对CDK1/2/5,EGFR,FGFR,PDGFR,InsR等没有抑制活性。Phase 3。

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RMB 902.49 现货
RMB 1406.17 现货
RMB 4670.26 现货
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客户使用该产品的10个实验数据:

  • FACS profiles for cell cycle synchronization of HCT116 cells pulsed with EdU. Asynchronous (AS) HCT116 cells were treated with CDK4/6i (Palbociclib, 2 μM) for 20 hours to arrest in G0/G1 (middle panel), followed by a wash in fresh media for 8 hours to release into S phase (right panel).

    Cell, 2018, 174(5):1127-1142. Palbociclib (PD-0332991) HCl purchased from Selleck.

    PD-0332991 causes inhibition of proliferation of EAC cells in a dose-dependent manner. Western blots showing the phosphorylation status of pRB at Ser780 and Ser795 after incubation with 125 nmol/L PD-0332991 for 24 and 72 hours. Reduction in cyclin A expression and the expression of RB2 (p130) tumor suppressor 72 hours after PD-0332991 treatment are shown (bottom). Total pRB (RB1) and actin are loading controls and T293 cell lysate (293) is a positive control for total pRB and phospho-pRB (Ph-RB). E, anchorage-independent growth of the 3 cell lines in the presence or absence (Cnt) of 125 nmol/L PD-0332991 for 3 weeks.

    Clin Cancer Res 2011 17(13), 4513-22. Palbociclib (PD-0332991) HCl purchased from Selleck.

  • b, c MelJuso cells were treated for 12–48 h with 1 µM Selumetinib or 5 µM Palbociclib and the cells were fixed, stained with propidium iodide and cell cycle distribution was determined by flow cytometry (b) and whole cell extracts were fractionated by SDS-PAGE, transferred onto PVDF membrane and immuno-blotted with the indicated antibodies (c). Data is from a single experiment representative of three separate experiments with similar results. The data in (b) are mean ± S.D. from a single experiment with three replicate dishes of cell per data point; similar results were obtained in two additional experiments

    Cell Mol Life Sci, 2016, 73(4):883-900. Palbociclib (PD-0332991) HCl purchased from Selleck.

    (A) Percentage of DN3a cells in S-phase (as gated on DAPI profile) from control (Zfp36l1/2fl/fl) and Zfp36l1/2fl/fl; CD2Cre (DCKO) mice, after 1 d of treatment with vector or palbociclib (drug).

    J Immunol, 2016, 197(7):2673-85. Palbociclib (PD-0332991) HCl purchased from Selleck.

  •  

    Patient tumor cell sensitivity to combinatorial treatment with histone deacetylase (HDAC)/cyclin-dependent kinase (CDK) inhibitors in 3-D culture. The effect of each drug or drug combination was assessed by fluorescent dye to identify live (green) and dead cells (red). Cells from breast reduction patients were used as non-cancer control in the assay.

    Pharmacogenomics J 2013 13(1), 94-104. Palbociclib (PD-0332991) HCl purchased from Selleck.

    The expression of respective proteins in CDK4/6-Rb-apoptosis pathway in cells was examined by Western blot after 3 days of palbociclib treatment.

    Biochim Biophys Acta, 2018, 1864(5 Pt A):1573-1582. Palbociclib (PD-0332991) HCl purchased from Selleck.

  •  

    Cdk4 is upregulated in ARMS and mMSCs transfected with PAX7-FKHR fusion gene (MP7F), and can be specifi cally inhibited. D: IF results showing overexpression of cdk4 in MP7F cells compared to parental mMSCs and reduced expression of cdk4 after treatment of MP7F cells with the cdk4 inhibitor, PD-0332991. E: IF results showing MyoD1 expression in parental mMSCs cells, and MP7F cells untreated and after treatment with the cdk4 inhibitor, PD-0332991.

    Clin Transl Oncol 2012 14(3), 197-206 . Palbociclib (PD-0332991) HCl purchased from Selleck.

    WM3734 melanoma cells were treated by PD-0332991 for 36 hours; melanoma cells treated by Doxorubicin (DXR)  at 0.5 μM is included as a control.

     

     

    Dr. Gao Zhang of University of Pennsylvania. Palbociclib (PD-0332991) HCl purchased from Selleck.

  • Serum-deprived T98G glioma cells are restimulated with serum(FBS) with or without 1 μΜ PD-0332991.

     

     

    Dr. Sabine Paternot and Dr Pierre Roger of IRIBHM, ULB, Brussels. Palbociclib (PD-0332991) HCl purchased from Selleck.

    P16INK4A knockdown in INK4A/ARF-wt human glioma cell LN319 potentiates PDGF-Apromoted anchorage-dependent growth in vitro. Soft agar growth of Ink4a/Arf-deficient mAst and LN444 cells treated with PD0332991. (A) IB analysis. (B) Quantification of soft agar assays. β-actin was used as a loading control in all IB experiments. Data are presented as mean ± s.d. and representative of two independent experiments. **, P < 0.01; ***, P < 0.001

    Dr. Kun-Wei Liu from University of Pittsburgh. Palbociclib (PD-0332991) HCl purchased from Selleck.

产品安全说明书

CDK抑制剂选择性比较

生物活性

产品描述 Palbociclib (PD-0332991) HCl是一种高度选择性的CDK4/6抑制剂,无细胞试验中IC50分别为11 nM/16 nM。它对CDK1/2/5,EGFR,FGFR,PDGFR,InsR等没有抑制活性。Phase 3。
特性 PD-0332991作为有应用前景的工具测定CDK激酶是否具有明显的治疗价值。
靶点
CDK4/CyclinD3 [1]
(Cell-free assay)
CDK4/CyclinD1 [1]
(Cell-free assay)
CDK6/CyclinD2 [1]
(Cell-free assay)
9 nM 11 nM 15 nM
体外研究

PD 0332991 对其他蛋白激酶包括EGFR, FGFR, PGFR, IR等没有抑制效果。 PD 0332991作用于Cdk4时是非ATP竞争性抑制剂。PD 0332991抑制MDA-MB-435乳腺癌细胞,IC50为66 nM,是由于Rb 在Ser780的磷酸化作用下降。PD 0332991抑制胸苷合并到Rb阳性的人类乳腺癌,结肠癌 肺癌,及白血病的DNA中,IC50值为4 nM到0.17 μM。PD 0332991作用于Rb阴性细胞没有抑制效果。PD 0332991作用于MDA-MB-453乳腺癌细胞和结肠-205细胞使细胞积累在G1期。[1]PD 0332991也有效作用于骨髓瘤5T33MM细胞,使细胞对Bortezomib敏感。[2]PD 0332991抑制luminalER-阳性和HER2-增强的乳腺癌细胞系,包括MDA-MB-175 ZR-75-30 CAMA-1 MDA-MB-134 HCC-202 UACC-893 等等。在这些细胞系中,PD 0332991增强Tamoxifen和Trastuzumab 的活性。在MCF7抗Tamoxifen细胞中,PD 0332991也增强tamoxifen 的敏感性。[3] 最新研究显示PD 0332991可以抑制恶性横纹肌样肿瘤(MRT)细胞系包括MP-MRT-AN, KP-MRT-RY, G401, KP-MRT-NS,且MRT细胞系对PD 0332991敏感性和p16表达呈负相关。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MOLM13 NGXKeJJMcW6jc3WgRZN{[Xl? NEP3TnIzPCCq NUW0bnI{UW6qaXLpeIlwdiCxZjDDSGs1KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhWmJicHjvd5Bpd3K7bHH0bY9vKHerdHigTWM2OCCxZjCwMlAxOiEQvF2= MlrlNlQ3PDFzMEO=
COLO205 M4HOTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rJblczKGh? MV\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5Nme3OnZDDhd{BqdmOxcoDvdoF1cW:wIH;mJHs{UF22aIntbYRqdmViaX70c{BFVkFid3n0bEBKSzVyIH;mJFAvODN4IN88US=> NVn0cnhzOjR4NEGxNFM>
U937 NIHQcHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLoO|IhcA>? MXjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5Nme3OnZDDhd{BqdmOxcoDvdoF1cW:wIH;mJHs{UF22aIntbYRqdmViaX70c{BFVkFid3n0bEBKSzVyIH;mJFAvOTRizszN M3rFR|I1PjRzMUCz
MOLM13 M1iyVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnqO|IhcA>? MVLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2RTF2xN{Bk\WyuczDoZZJjd3KrbnegSmxVOyCLVFSgcZV1[W62IHHzd4V{e2WmIHHzJIlv[2:{cH;yZZRqd25ib3[gX|NJZXSqeX3p[Ilv\SCrboTvJGRPSSC5aYToJGlEPTBib3[gNE4xQTZizszN NGn3XpAzPDZ2MUGwNy=>
MOLM13 MknFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2j6TlczKGh? NWG1Z5MxSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEB{d3KjZnXubYIuemW|aYP0ZY51KGi3bXHuJG1QVE1zMzDj[YxteyCjc4Pld5Nm\CCjczDpcoNwenCxcnH0bY9vKG:oIGuzTH11cHmvaXTpcoUhcW62bzDEUmEhf2m2aDDJR|UxKG:oIECuNFk3KM7:TR?= MVOyOFY1OTFyMx?=
MDA-MB-435 NHO5VWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4[wZVI1KGh? NGTu[XNKSzVyPUCuNVYh|ryP MmXINVU5ODF6M{G=
K562 MVzDfZRwfG:6aXOgRZN{[Xl? NVjyV294QTZiaB?= MoDUSG1UVw>? MnjKTWM2OD1{IN88US=> MUmyOFQyPzV4Nh?=
DU145 MlziR5l1d3SxeHnjJGF{e2G7 NVrZXWUxQTZiaB?= NXTiV5VtTE2VTx?= MnH6TWM2OD15LkWg{txO NUj4bI9HOjR2MUe1OlY>
MDA-MB-231 NHX0eFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;YV|N6OSEQvF2= M1nKXVI1KGh? NFnSNlNFVVOR MoLFR4VtdCCleXPs[UBienKnc4SgZZN{\XO|ZXSgZZMh[WOldX31cIF1cW:wIHH0JGcyKHCqYYPl NX36c4ZwOjR2MUe1OlY>
MCF7 NELoXo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnr6NUDPxE1? NFW4cIQzPCCq NE\LU4lFVVOR MlTGR4VtdCCleXPs[UBienKnc4SgZZN{\XO|ZXSgZZMh[WOldX31cIF1cW:wIHH0JGcyKHCqYYPl MUSyOFQyPzV4Nh?=
MCF7 NFG1cnlMcW6jc3WgRZN{[Xl? MVG1JO69VQ>? MmfZNlQhcA>? MnTNSG1UVw>? NX7yPZRPUW6qaXLpeIlwdiCxZjDy[YNwdWKrbnHueEBETEt2L3P5Z4xqdkRzIHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZicnX0bY5w[myjc4TvcYEheGixc4Doc5J6dGG2aX;uJIF1KFOncke4NC=> MWiyOFQyPzV4Nh?=
MDA-MB-231 MoDJT4lv[XOnIFHzd4F6 M2i5[VUh|ryP MoXaNlQhcA>? MlO4SG1UVw>? NVXkPZhIUW6qaXLpeIlwdiCxZjDy[YNwdWKrbnHueEBETEt2L3P5Z4xqdkRzIHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZicnX0bY5w[myjc4TvcYEheGixc4Doc5J6dGG2aX;uJIF1KFOncke4NC=> MVWyOFQyPzV4Nh?=
MDA-MB-231 NYjiVZNDTnWwY4Tpc44hSXO|YYm= NEDF[JUyNTFyIN88US=> NETCbmMzPCCq NV3kN2VnTE2VTx?= Mlnq[I9meyCwb4SgbY5lfWOnIHHwc5B1d3OrczDhd5Nme3OnZDDhd{BRSVKSIHPs[YF3[Wen MUWyOFQyPzV4Nh?=
MCF7 M33aeGZ2dmO2aX;uJGF{e2G7 NInGUXUyNTFyIN88US=> MU[yOEBp MVHEUXNQ M1P4XoRw\XNibn;0JIlv\HWlZTDhdI9xfG:|aYOgZZN{\XO|ZXSgZZMhWEGUUDDjcIVifmGpZR?= M1[5e|I1PDF5NU[2
MDA-MB-231 NV\VS3dyTnWwY4Tpc44hSXO|YYm= NUjnPWs5OC53LUGg{txO NGHFbWk1QCCq NWDxRmd[TE2VTx?= MnrWbIF{KG6xIFPlcIwh[3mlbHWgZZJz\XO2IHHzd4V{e2WmIHHzJIFk[3WvdXzheIlwdiCjdDDzeYIuTzFicHjhd4U> NXi0RmlpOjR2MUe1OlY>
MCF7 Mnm2SpVv[3Srb36gRZN{[Xl? M17GVFAvPS1zIN88US=> MXK0PEBp NVjTcYhuTE2VTx?= MoHobIF{KG6xIFPlcIwh[3mlbHWgZZJz\XO2IHHzd4V{e2WmIHHzJIFk[3WvdXzheIlwdiCjdDDzeYIuTzFicHjhd4U> MUGyOFQyPzV4Nh?=
697 NWToV3NIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrVeplKSzVyPUG0PE4{QCCwTR?= NFvwd5JUSU6JRWK=
P12-ICHIKAWA NIHLVlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfxTGgzUUN3ME25Ok4xPCCwTR?= Ml7qV2FPT0WU
NB69 NIXZZY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\SRWpiUUN3ME2xOlEvQCCwTR?= MlTtV2FPT0WU
EoL-1 M{W3Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1qzc2lEPTB;MUi3MlI3KG6P NEDOR5lUSU6JRWK=
BHT-101 NX32RXZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;BemlEPTB;MUm4MlI2KG6P NWjZTIE2W0GQR1XS
SK-NEP-1 MnS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3LeGFYUUN3ME2yNlAvODJibl2= MnjFV2FPT0WU
MHH-NB-11 NGDFZYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTJ{MD6xPUBvVQ>? M{Tq[XNCVkeHUh?=
AsPC-1 MlrBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVn3O41iUUN3ME2yOVIvPTNibl2= NWPGd5dHW0GQR1XS
ES1 M4nSdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\xbGlEPTB;MkW2MlI2KG6P MUXTRW5ITVJ?
LAMA-84 NVv1UI8{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFi2OmFKSzVyPUK1PE4yQSCwTR?= M3TQW3NCVkeHUh?=
MOLT-16 MnrIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWW2b3o3UUN3ME2yOVgvPDlibl2= NX:2WFY2W0GQR1XS
ES7 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPxTWM2OD1{N{OuNFkhdk1? MlzwV2FPT0WU
KY821 M4PQbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3P4eGlEPTB;M{G0MlEhdk1? Mke3V2FPT0WU
RT-112 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\HcGlEPTB;M{KxMlA2KG6P Mk\KV2FPT0WU
HL-60 M3v3d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTN2MD62OkBvVQ>? M{HDV3NCVkeHUh?=
MOLT-4 NWLtZ2lOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2GxUmlEPTB;M{S1MlE{KG6P NYW1cY9iW0GQR1XS
KARPAS-45 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDWfHhKSzVyPUO3Ok4yPiCwTR?= NVTxWo82W0GQR1XS
SK-N-AS Ml60S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LYeGlEPTB;M{i3Mlg{KG6P M{\IRnNCVkeHUh?=
CTB-1 Mk[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfhTWM2OD12MEWuNFIhdk1? M4jpVnNCVkeHUh?=
NKM-1 NEL2Sm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XmZWlEPTB;NEGxMlg6KG6P MVLTRW5ITVJ?
HTC-C3 NYTpSplXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzUSW1XUUN3ME20N|IvQTVibl2= NULkSpZkW0GQR1XS
BE-13 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTR2ND6yO{BvVQ>? NEPhXlJUSU6JRWK=
KOSC-2 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLXTWM2OD12Nk[uPUBvVQ>? NELDe4RUSU6JRWK=
NB14 MorXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHRTWM2OD12OEOuOVghdk1? NHT5XY5USU6JRWK=
CAL-27 NEToenVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnOUoJ1UUN3ME20PVQvPTlibl2= MmPSV2FPT0WU
H9 M1\I[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHETWFKSzVyPUS5OU41OyCwTR?= MWPTRW5ITVJ?
RS4-11 NF[zXFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTrXnRuUUN3ME21NFQvPzNibl2= MlSxV2FPT0WU
PA-1 NVfJZ4V6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\WVpVKSzVyPUWwPU45PiCwTR?= MX7TRW5ITVJ?
MV-4-11 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHuxWplKSzVyPUWxN{45PSCwTR?= M3fIfXNCVkeHUh?=
OS-RC-2 M4XT[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTV{MT62NkBvVQ>? MX;TRW5ITVJ?
RPMI-8226 M3v4fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPidWxKSzVyPUWyOk45PiCwTR?= Mnn6V2FPT0WU
HGC-27 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3pTYlKSzVyPUW2OE46QSCwTR?= NUDG[GZtW0GQR1XS
CHP-212 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnNd2w4UUN3ME21PVMvPTlibl2= MmPyV2FPT0WU
NB10 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTV7OT6xPEBvVQ>? Mn\4V2FPT0WU
HH NFvRd3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEP1enNKSzVyPUW5PU41OyCwTR?= MYLTRW5ITVJ?
EW-16 Mn;0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\Re2lEPTB;NkCzMlUzKG6P NGP0bW1USU6JRWK=
ES8 NI[3VZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\KTWM2OD14MEWuNlEhdk1? NHfuZlNUSU6JRWK=
HAL-01 NHzDVodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfUZW9KSzVyPU[wOU43PyCwTR?= NWH2fpRMW0GQR1XS
A204 NV7rXY42T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NID5NXpKSzVyPU[zN{46OSCwTR?= M4XTNXNCVkeHUh?=
MHH-PREB-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIi1emVKSzVyPU[zOk46QSCwTR?= NX3aRWtuW0GQR1XS
EM-2 NWnSbVMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\1eGlEPTB;NkWwMlY1KG6P MkfyV2FPT0WU
BV-173 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTZ3Mj60PEBvVQ>? NVfGNHZJW0GQR1XS
ONS-76 M3zn[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTZ5Nz64NkBvVQ>? MXfTRW5ITVJ?
KM-H2 NFTrcoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HsOmlEPTB;Nkm1MlU1KG6P MnmyV2FPT0WU
D-263MG NUjUVFBtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIe4O5BKSzVyPUexO{4yOiCwTR?= NXraVoRxW0GQR1XS
ES3 M3zrXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTd{OD65N{BvVQ>? NX:xNnF{W0GQR1XS
VA-ES-BJ NFPQNW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX6zUG52UUN3ME23N|IvOjdibl2= MnXGV2FPT0WU
NBsusSR Mk\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXFbmRKSzVyPUe0Nk46QSCwTR?= MXPTRW5ITVJ?
NCI-H520 MlXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonnTWM2OD15NE[uOVIhdk1? MmnpV2FPT0WU
ES5 NEnNfWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTd3Mj64JI5O M2XBNHNCVkeHUh?=
T-24 NITxTZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTd5OD63NUBvVQ>? MkLMV2FPT0WU
SW962 M1;HT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\jTWM2OD16MEiuOlMhdk1? NXPnWVZoW0GQR1XS
EW-3 M3nTb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXH3e4F2UUN3ME24NFgvPzZibl2= NHjBRZZUSU6JRWK=
RXF393 NInqe|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHyb4NKSzVyPUixNk44QSCwTR?= MoW0V2FPT0WU
U251 M1jFWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGiy[mFKSzVyPUixN{45QCCwTR?= MVrTRW5ITVJ?
CAMA-1 NWXwXGFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTpTWM2OD16M{OuPVQhdk1? NYTrPGlZW0GQR1XS
JVM-3 NGrl[HRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHJZ5BtUUN3ME24OVEvPzhibl2= MlLBV2FPT0WU
COLO-800 Ml6xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTh7Nz63PEBvVQ>? MUfTRW5ITVJ?
OVCAR-5 M4jsPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTlyMD6xJI5O NIHmPFVUSU6JRWK=
LB1047-RCC MofoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTwTWM2OD17MkeuOVYhdk1? M{XoeHNCVkeHUh?=
SW954 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;GTWM2OD17MkmuOFEhdk1? MonzV2FPT0WU
J-RT3-T3-5 MkP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDJTXB7UUN3ME25N|YvODZibl2= MkfyV2FPT0WU
Mewo NWXuNYg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTl|Nj62JI5O NYXteVN3W0GQR1XS
NCI-H1770 NWr0VJZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXG5V2htUUN3ME25OFAvPTVibl2= MV3TRW5ITVJ?
HO-1-N-1 NFLweY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTUTWM2OD17NkKuPFEhdk1? MXTTRW5ITVJ?
HSC-3 M2LNOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTl4Nj60PEBvVQ>? MlzKV2FPT0WU
TYK-nu NH\hPWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HEcGlEPTB;OUm4MlI2KG6P NWLq[WRPW0GQR1XS
KYSE-150 MmfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPIVFl[UUN3ME2xMlAxODd4IN88US=> MX3TRW5ITVJ?
SN12C MnzIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfESYxKSzVyPUGuNFA5PzVizszN NGTQRnNUSU6JRWK=
MOLT-13 NWXMVYJoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvwOZBKSzVyPUGuNFE1OjFizszN M4jvTnNCVkeHUh?=
TE-11 M1G4[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXZOm1KSzVyPUGuNFQ5OTJizszN NUftSYNOW0GQR1XS
DB NHPiOXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jjdGlEPTB;MT6wO|I4OyEQvF2= M3LhdHNCVkeHUh?=
CAL-39 NXW1OFJqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fkcGlEPTB;MT6wO|UzOiEQvF2= M1O5bXNCVkeHUh?=
A3-KAW MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLRNndKUUN3ME2xMlA5PDB6IN88US=> MYrTRW5ITVJ?
CHP-134 NIC4eHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TQcGlEPTB;MT6xNVgxPyEQvF2= MYrTRW5ITVJ?
TGW NYHNcWlHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjnTWM2OD1zLkGyN|k2KM7:TR?= M3jFR3NCVkeHUh?=
QIMR-WIL NFiy[ZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfJZpdKSzVyPUGuNVMyOzRizszN MXLTRW5ITVJ?
NCI-SNU-1 M3fybWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXzbmlKSzVyPUGuNVY{PTRizszN MonoV2FPT0WU
CGTH-W-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrB[I1KSzVyPUGuNVcyQDZizszN MWDTRW5ITVJ?
MHH-ES-1 NH\kc2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rWdWlEPTB;MT6xO|k5PiEQvF2= M1rqcXNCVkeHUh?=
LB2241-RCC MmLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLLTWM2OD1zLkG4OlIh|ryP MWXTRW5ITVJ?
ML-2 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{C4S2lEPTB;MT6yNFc{PCEQvF2= NXfHNZdKW0GQR1XS
COR-L23 NVqxWmpzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTFwMkK5N|Mh|ryP MnHSV2FPT0WU
BFTC-905 MnXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1K2e2lEPTB;MT6yOFI3PyEQvF2= MW\TRW5ITVJ?
Hs-578-T M2rlOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTFwMkW4NVch|ryP NHfQNVlUSU6JRWK=
KG-1 NEjVeJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTFwMk[2PFYh|ryP NVT0VmY2W0GQR1XS
HEL NIDSb3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLBTWM2OD1zLkK5N|M5KM7:TR?= MV;TRW5ITVJ?
A549 NXTFW2doT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3f2emlEPTB;MT6yPVM6QSEQvF2= NYj4W4h7W0GQR1XS
COLO-741 MkXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\aTWM2OD1zLkOyNFg6KM7:TR?= MYHTRW5ITVJ?
PC-3 NYLGeGJxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrwVYVKSzVyPUGuN|UzOjFizszN NF\2fVVUSU6JRWK=
HOS NVnSVJZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHzRm44UUN3ME2xMlM2Ojl4IN88US=> M{\HVnNCVkeHUh?=
HT-1080 MmX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3X3WWlEPTB;MT6zO|UyQSEQvF2= MV;TRW5ITVJ?
TE-8 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfET21KSzVyPUGuOFE4PzRizszN MlPHV2FPT0WU
BHY NVzj[nVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DCV2lEPTB;MT60OlkzOyEQvF2= MlXWV2FPT0WU
BB65-RCC MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULlSYpMUUN3ME2xMlUxPTJ6IN88US=> M3X3N3NCVkeHUh?=
HN M{e2Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTUT2xKSzVyPUGuOVQxPzFizszN M4CwdXNCVkeHUh?=
NCI-H441 M3LUTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzSeY1KSzVyPUGuOVQ6ODdizszN MYHTRW5ITVJ?
RPMI-8866 MlH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7xSWRKSzVyPUGuOVg2ODdizszN NGLHbmtUSU6JRWK=
CAL-62 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TRd2lEPTB;MT62NFg3OiEQvF2= NYPsW5dPW0GQR1XS
MG-63 M37hfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTFwNkG4NVMh|ryP MkDQV2FPT0WU
SK-LU-1 NX7zXXNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXMTWM2OD1zLk[yNVUzKM7:TR?= NX\vW5g1W0GQR1XS
BCPAP MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTFwNk[0OVch|ryP MmjZV2FPT0WU
22RV1 NHfrPZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTFwNke4OFMh|ryP MnHTV2FPT0WU
T47D M3Pnbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTFwNkiwOlEh|ryP M3nVUXNCVkeHUh?=
MSTO-211H MlqyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTFwNkm2NFMh|ryP M1vvXnNCVkeHUh?=
DEL M3rRZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;pTWM2OD1zLkewNlc{KM7:TR?= M3u3fXNCVkeHUh?=
H4 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3KxTGlEPTB;MT63N|IyOiEQvF2= NHLSWXdUSU6JRWK=
CAL-51 M3[5Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PHc2lEPTB;MT63OFg2PSEQvF2= M1jCUHNCVkeHUh?=
ABC-1 M3qwcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTFwN{i1PFIh|ryP M4TQRnNCVkeHUh?=
MZ2-MEL NWLWNXJmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTFwN{m1OFIh|ryP NXizc4pbW0GQR1XS
YKG-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TndmlEPTB;MT64NVA3OSEQvF2= Mn34V2FPT0WU
KM12 NH;rd5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHJTWM2OD1zLkixOlAzKM7:TR?= M2TnbHNCVkeHUh?=
L-363 NUHGT5Z1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmOyTWM2OD1zLki3OFEzKM7:TR?= NXTLeXIyW0GQR1XS
KU812 M3jtd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPmdIdYUUN3ME2xMlg6Ojh{IN88US=> NWjkdHlVW0GQR1XS
LOXIMVI MnrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG[5XGhKSzVyPUGuPVEzOjhizszN NYPzOo9EW0GQR1XS
G-401 M2DtU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\LZ2lEPTB;MT65NlQzQCEQvF2= NH7ydWRUSU6JRWK=
SW780 M1XtZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlr0TWM2OD1zLkm2NlQ3KM7:TR?= MnfyV2FPT0WU
SW872 Mn3yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHOTWM2OD1zLkm4N|Mh|ryP NHizOIxUSU6JRWK=
NB7 NUPLcZU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfKTWM2OD1zLkm5N|I{KM7:TR?= NITp[nlUSU6JRWK=
T98G M2Xaemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnFUHpKSzVyPUKuNFA3PjZizszN MV7TRW5ITVJ?
SW1710 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HYSWlEPTB;Mj6wOlk1PSEQvF2= MVHTRW5ITVJ?
NCI-H1573 Mk\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXXVIFKSzVyPUKuNFczQThizszN NGf0VYpUSU6JRWK=
KE-37 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TtcGlEPTB;Mj6wPFk2OSEQvF2= M4rzUnNCVkeHUh?=
786-0 NV7BOlRtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TObWlEPTB;Mj6xOVQ{QSEQvF2= MnPBV2FPT0WU
SAS M{Gxemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTJwMkCzO|Qh|ryP MXrTRW5ITVJ?
CAL-54 NVfaXmRNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorsTWM2OD1{LkKwOFE{KM7:TR?= MnXCV2FPT0WU
SF268 NHPFdYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3[5[mlEPTB;Mj6yN|EzOiEQvF2= NGPze3NUSU6JRWK=
SW620 MmrJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnpV5NUUUN3ME2yMlI3OTZ7IN88US=> MUPTRW5ITVJ?
MN-60 MoH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\RTWM2OD1{LkOxNFYh|ryP MV3TRW5ITVJ?
EFO-27 MnXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrSTFJ6UUN3ME2yMlMzODV6IN88US=> NV;ZN21NW0GQR1XS
NCI-H747 M3PEcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDmTWM2OD1{LkOyNVk6KM7:TR?= M1\uSnNCVkeHUh?=
HCC2218 NGr0XpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M16xPWlEPTB;Mj6zOVM4PCEQvF2= NIKwUmxUSU6JRWK=
MIA-PaCa-2 MnvDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkThTWM2OD1{LkO2OFM4KM7:TR?= NWLLZXZ5W0GQR1XS
SJSA-1 NHO1OpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;hdWtKSzVyPUKuN|c4QTZizszN MmHyV2FPT0WU
RKO NHLONYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnye4NKSzVyPUKuN|g1QTZizszN M{exWnNCVkeHUh?=
NB6 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTJwNECzO|Qh|ryP Mlj2V2FPT0WU
ES4 NFixTpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGP4XnNKSzVyPUKuOFU1OjJizszN M3r6NnNCVkeHUh?=
EGI-1 Ml3pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTJwNE[4PFMh|ryP NX\1bnB{W0GQR1XS
CTV-1 M{\sRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HENGlEPTB;Mj61Nlc4OyEQvF2= NXPMdZlNW0GQR1XS
NCI-H1355 NXny[XVmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\6VVlXUUN3ME2yMlU2QTVzIN88US=> NFrkNGJUSU6JRWK=
GT3TKB M1vMSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULsNmpSUUN3ME2yMlU6OTl7IN88US=> MnLtV2FPT0WU
SK-HEP-1 MnfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TCOGlEPTB;Mj61PVI3PiEQvF2= NVTyeVluW0GQR1XS
GAMG NYPFW|dsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPITYU6UUN3ME2yMlU6Ozl2IN88US=> NVztfXJvW0GQR1XS
SK-MES-1 M3Pvemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTEc2pKUUN3ME2yMlYyQDB|IN88US=> M1zjRXNCVkeHUh?=
RO82-W-1 MmXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\mVXFKSzVyPUKuOlIxPTdizszN NVno[Y9pW0GQR1XS
ECC10 NWTxVVhYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HJSmlEPTB;Mj63NFIxPiEQvF2= NUWy[4hsW0GQR1XS
MCF7 M1yxO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLOXFVXUUN3ME2yMlcyPDZ2IN88US=> NGLwOFdUSU6JRWK=
D-283MED NFHV[GhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LRXmlEPTB;Mj63NlQ{KM7:TR?= NEfHXWRUSU6JRWK=
RPMI-7951 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTJwN{W2PVQh|ryP NH\qfGxUSU6JRWK=
Ramos-2G6-4C10 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTJwN{ewPVkh|ryP Ml\DV2FPT0WU
KGN NWHHfFlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDvelR{UUN3ME2yMlgyQDh2IN88US=> NYHYV3l6W0GQR1XS
NUGC-3 M2jPdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTJwOEK1NFUh|ryP MkLGV2FPT0WU
NCI-H292 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rae2lEPTB;Mj64OVA2OyEQvF2= MlXrV2FPT0WU
Becker MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnCTWM2OD1{Lkm1PFMzKM7:TR?= M4j2W3NCVkeHUh?=
NCI-H1299 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjy[5lKUUN3ME2zMlA2OjZ|IN88US=> NYryZmRTW0GQR1XS
ETK-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTNwMEW0N{DPxE1? NHnMSYJUSU6JRWK=
TK10 Mnv6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWq0RVZNUUN3ME2zMlIxOTZ3IN88US=> NUPscm9RW0GQR1XS
VMRC-RCZ MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTNwM{[0PFgh|ryP NUH6R4pEW0GQR1XS
YH-13 Mmi5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1[wdmlEPTB;Mz60OFA4QSEQvF2= NUPQeo5HW0GQR1XS
DU-145 M2HnfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTRTWM2OD1|LkS2NlY6KM7:TR?= NWLEO4prW0GQR1XS
SW1088 NXPXfWxyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTNwNEe0O{DPxE1? NH61WYRUSU6JRWK=
HOP-92 M2HX[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHITWM2OD1|LkWwN|QzKM7:TR?= NYHET|FHW0GQR1XS
KP-N-YS Mn7KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTNwNkKxN|kh|ryP NGr0UJNUSU6JRWK=
NCI-H460 M2jROmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTGNGs2UUN3ME2zMlY3PzNizszN NEnoT5ZUSU6JRWK=
U-2-OS MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUKyNm1FUUN3ME2zMlczPTN3IN88US=> M{X4XHNCVkeHUh?=
A101D NHHxUmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnMTWM2OD1|Lke2PVM3KM7:TR?= M{LnWnNCVkeHUh?=
MDA-MB-231 M{flZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTNwOEG5OVEh|ryP NED4d4tUSU6JRWK=
IST-MES1 NXPDfWprT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXS1SZI6UUN3ME2zMlg{OiEQvF2= M{\ieXNCVkeHUh?=
COR-L105 NIrZTHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPufJpKSzVyPUSuNFE5KM7:TR?= NWXJV|l{W0GQR1XS
NCI-H1437 NFHNNYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPvTWM2OD12LkCyN|AzKM7:TR?= MYXTRW5ITVJ?
CAL-85-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3jTWM2OD12LkCyOFYyKM7:TR?= M2q1SHNCVkeHUh?=
MZ1-PC MmPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIC0S41KSzVyPUSuNVg2PTZizszN MWHTRW5ITVJ?
VM-CUB-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXGZ2ZKSzVyPUSuN|EzQDRizszN MX\TRW5ITVJ?
CHL-1 NHezTWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvPe5VKSzVyPUSuN|IyPjlizszN NIG4WWxUSU6JRWK=
MDA-MB-361 M2i5PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXaPHRoUUN3ME20MlM{OTV|IN88US=> MmDyV2FPT0WU
NCI-H661 M1vidmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnNTWM2OD12LkWwNFkzKM7:TR?= M376OXNCVkeHUh?=
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HLE NH\RN2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17OTGlEPTB;MUSuN|g2OiEQvF2= M3[wdHNCVkeHUh?=
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NCI-H2291 M{LZSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTJ4Lk[1OFEh|ryP Mo\yV2FPT0WU
BALL-1 NIP5XVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTJ4LkmzPVch|ryP NYfadJplW0GQR1XS
HCC1954 MmnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nVTWlEPTB;Mk[uPVgxQCEQvF2= MUDTRW5ITVJ?
NCI-H2452 NWe4WFl{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1u1SGlEPTB;MkeuOFE3OyEQvF2= NEnlW|lUSU6JRWK=
LU-99A M3fpSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13TOGlEPTB;MkeuOVU5OiEQvF2= M1G5bXNCVkeHUh?=
NTERA-S-cl-D1 M3zEeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LYS2lEPTB;MkeuO|I6QSEQvF2= MYfTRW5ITVJ?
PANC-10-05 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmGyTWM2OD1{Nz63O|c2KM7:TR?= M2rnTnNCVkeHUh?=
NCI-H2405 MmC1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIn0O3VKSzVyPUK3Mlk{QDdizszN MWPTRW5ITVJ?
MDA-MB-415 M2TGeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTJ6LkSxN|ch|ryP MV;TRW5ITVJ?
NCI-H2342 M33DOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXS2VG9QUUN3ME2yPE42OjhzIN88US=> M1fHbHNCVkeHUh?=
TGBC24TKB MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvHVHpKSzVyPUK4MlcyOTdizszN NVvQUldDW0GQR1XS
LU-134-A NWrSOGl5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfQTWM2OD1{OD65NlYyKM7:TR?= NWH5cGM4W0GQR1XS
SCC-4 NGXpTWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\5O|RKSzVyPUOxMlA1QTRizszN NH3VW4pUSU6JRWK=
Saos-2 NWLBWJNGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTNzLkmzNFYh|ryP NX70e4ZSW0GQR1XS
RERF-LC-MS MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7wTlMxUUN3ME2zNk45OjNzIN88US=> NGLUdIxUSU6JRWK=
M14 NVzvXHNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHK4NYdKSzVyPUOyMlk4PjRizszN NVnVV|RyW0GQR1XS
HPAF-II MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoiyTWM2OD1|Mz61NFEyKM7:TR?= Mn3SV2FPT0WU
NCI-H1755 NFLtfIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{C1VGlEPTB;M{SuN|MxPSEQvF2= NGjNTHNUSU6JRWK=
D-392MG MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTN3Lki2O|Qh|ryP NG[wdmJUSU6JRWK=
A704 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHrTVJyUUN3ME2zOk4xPDJ5IN88US=> NIrIW5lUSU6JRWK=
CP50-MEL-B NUixclZ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTN4LkG5NVEh|ryP MXvTRW5ITVJ?
EW-18 NXnsN5hRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXxTWM2OD1|Nj60OVIh|ryP NFjKTIZUSU6JRWK=
WM-115 M1fsOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTN4LkiwPVkh|ryP MoeyV2FPT0WU
LU-65 NGfjXJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTQNXJKSzVyPUO3MlE1OTdizszN NUPS[4NJW0GQR1XS
NCI-H1563 NXzBWZhpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmGyTWM2OD1|Nz6yOFg1KM7:TR?= M1i4SXNCVkeHUh?=
DBTRG-05MG MontS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfZdHVwUUN3ME2zPE4xPjlzIN88US=> MoXCV2FPT0WU
NCI-H630 NETXcFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFG5TXhKSzVyPUO4MlQ4OTRizszN MlHsV2FPT0WU
NCI-H1155 MkfIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTN7LkK0NkDPxE1? MlzMV2FPT0WU
OVACR-3 NIPnfJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jFfmlEPTB;M{muPVE6PSEQvF2= NV:yXVNxW0GQR1XS
OAW-42 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHOTWM2OD12MD60NlU5KM7:TR?= NGLXfIlUSU6JRWK=
JVM-2 MkPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17yeGlEPTB;NEGuNlQyPSEQvF2= NHezNmhUSU6JRWK=
C3A M2jzcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTRzLkO0OFch|ryP M3zPTXNCVkeHUh?=
HT55 NEjHOVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFz3ZY5KSzVyPUSyMlI5PDFizszN NGLofJpUSU6JRWK=
OVCAR-4 NXjUcW1ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHXO3JKSzVyPUSyMlI6PzRizszN M2[4VnNCVkeHUh?=
MEG-01 M{jDPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnjcVZKSzVyPUSyMlQ3OTZizszN M4LUbHNCVkeHUh?=
NCI-H82 M1zoVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;YdGlEPTB;NEOuPVg6OiEQvF2= NFXpXnFUSU6JRWK=
JEG-3 MlzxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvhTllKSzVyPUS0Mlk1PyEQvF2= NEjoZ|NUSU6JRWK=
BPH-1 NHHYPFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PKcWlEPTB;NE[uN|k6QCEQvF2= MUHTRW5ITVJ?
MPP-89 NXzTXXhZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTR5LkK4PVgh|ryP NH71S3pUSU6JRWK=
ALL-PO NWXtRnhbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkD3TWM2OD12Nz60NVg5KM7:TR?= NFzhb5hUSU6JRWK=
HT MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTBTWM2OD12Nz60PVIh|ryP MW\TRW5ITVJ?
NCI-H2347 NX7kWVdXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXyTWM2OD12OD6wO|E2KM7:TR?= NUWwTIloW0GQR1XS
A2780 MnjJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTtTWM2OD12OT60NlI5KM7:TR?= MWLTRW5ITVJ?
KARPAS-299 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HU[GlEPTB;NEmuOVEyQSEQvF2= M4m0dnNCVkeHUh?=
NCI-H1651 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGmxUJNKSzVyPUS5Mlg5OjFizszN NH6ySlhUSU6JRWK=

... Click to View More Cell Line Experimental Data

体内研究 150 mg/kg PD 0332991处理 MDA-MB-435移植瘤完全抑制肿瘤。在多种人类肿瘤移植瘤中,PD 0332991也显示广谱抗癌活性,通过除去血管中p-Rb和增殖Marker Ki-67,且调节基因使其处于E2F转录水平控制。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

+ 展开

Cdk实验:

PD0332991溶解在DMSO中。在96孔板上进行CDK 实验。通过杆状病毒感染,所有的CDK-cyclin 激酶复合体 在昆虫细胞中表达。实验底物为与GST融合的一段pRb。每孔体积为0.1 ml,包含:终浓度为20 mm Tris-HCl(pH 为7.4), 50 mmNaCl, 1 mm二硫苏糖醇, 10 mmMgCl2, 25 μm ATP (用于CDK4-cyclin D1, CDK6-cyclin D2,和CDK6-cyclin D3)或12 μm ATP (用于CDK2-cyclin E, CDK2-cyclin A, 和CDC2-cyclin B),0.25 μCi [γ-32P]ATP, 20 ng 酶, 1 μg GST·RB-Cterm, 及PD 0332991 (0.001-0.1μM)。除了[γ-32P]ATP的所有混合物加到孔中,放在搅拌器上搅拌2分钟。加入 [γ-32P]ATP开始反应, 在25 oC下温育15分钟。加入0.1 ml 20% 三氯乙酸终止反应, 在4 oC维持至少1小时,使底物沉淀。用0.2 ml 10%三氯乙酸冲洗5次,用β-计数器板测定掺入的放射性。
细胞实验:

[1]

+ 展开
  • Cell lines: MDA-MB-435, ZR-75-1, T-47D, MCF-7, H1299, Colo-205, MDA-MB-468, H2009, CRRF-CEM,和K562细胞
  • Concentrations: 0.01-1 μM
  • Incubation Time: 24小时
  • Method:

    肿瘤细胞包括MDA-MB-435, ZR-75-1, T-47D, MCF-7, H1299, Colo-205, MDA-MB-468, H2009, CRRF-CEM,及K562按每孔2×104个细胞接种在96孔板上,温育过夜。加入PD 0332991 (0.01-1 μM) ,37oC温育24小时。每孔加入[14C]胸甘(0.1 μCi) ,进行同位素示踪,持续72小时。用β-计数器板测定掺入的放射性。


    (Only for Reference)
动物实验:

[1]

+ 展开
  • Animal Models: 携带晚期人类肿瘤移植瘤,包括结肠-205, MDA-MB-435 乳腺癌, SF-295 恶性胶质瘤, ZR-75-1 乳腺癌, PC-3 前列腺癌, H125 肺癌, SW-620结肠癌, H23肺癌,及MDA-MB-468 乳腺癌 (Rb 阴性)的SCID鼠
  • Formulation: 溶解在乳酸钠buffer(50 mM, pH 4.0)中
  • Dosages: 0-150 mg/kg
  • Administration: 口服饲喂
    (Only for Reference)

溶解度 (25°C)

体外 Water 30 mg/mL (61.98 mM)
DMSO 3 mg/mL warmed (6.19 mM)
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
Saline
6 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 483.99
化学式

C24H29N7O2.HCl

CAS号 827022-32-2
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03709680 Not yet recruiting Solid Tumors|Ewing Sarcoma|Rhabdoid Tumor|Rhabdomyosarcoma|Neuroblastoma|Medulloblastoma Pfizer February 5 2019 Phase 1
NCT03609047 Not yet recruiting Breast Cancer Stage II|Breast Cancer Stage III European Organisation for Research and Treatment of Cancer - EORTC|Pfizer January 7 2019 Phase 2
NCT03691493 Not yet recruiting Anatomic Stage IV Breast Cancer AJCC v8|Estrogen Receptor Positive|HER2/Neu Negative|Metastatic Breast Carcinoma|Metastatic Malignant Neoplasm in the Bone|Progesterone Receptor Positive|Prognostic Stage IV Breast Cancer AJCC v8 Emory University|Pfizer December 1 2018 Phase 2
NCT03530696 Not yet recruiting HER2-positive Breast Cancer|Breast Cancer|Breast Cancer Stage|Recurrent Breast Cancer|Metastatic Breast Cancer|HER2 Positive Breast Carcinoma University of Arizona|Pfizer November 30 2018 Phase 2
NCT03531645 Not yet recruiting Malignant Neoplasms of Female Genital Organs M.D. Anderson Cancer Center|AstraZeneca|Pfizer November 2018 Phase 2
NCT03644186 Not yet recruiting Breast Cancer|Estrogen Receptor Positive Tumor|HER2-positive Breast Cancer International Breast Cancer Study Group|Pfizer|Hoffmann-La Roche October 2018 Phase 2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID