Palbociclib (PD-0332991) HCl

Pfizer辉瑞授权 目录号:S1116

Palbociclib (PD-0332991) HCl Chemical Structure

Molecular Weight(MW): 483.99

Palbociclib (PD-0332991) HCl是一种高度选择性的CDK4/6抑制剂,无细胞试验中IC50分别为11 nM/16 nM。它对CDK1/2/5,EGFR,FGFR,PDGFR,InsR等没有抑制活性。Phase 3。

规格 价格 库存 购买数量  
RMB 902.49 现货
RMB 1406.17 现货
RMB 4670.26 现货
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客户使用Selleck该产品发表文献155篇:

产品安全说明书

CDK抑制剂选择性比较

生物活性

产品描述 Palbociclib (PD-0332991) HCl是一种高度选择性的CDK4/6抑制剂,无细胞试验中IC50分别为11 nM/16 nM。它对CDK1/2/5,EGFR,FGFR,PDGFR,InsR等没有抑制活性。Phase 3。
特性 PD-0332991作为有应用前景的工具测定CDK激酶是否具有明显的治疗价值。
靶点
CDK4/CyclinD3 [1]
(Cell-free assay)
CDK4/CyclinD1 [1]
(Cell-free assay)
CDK6/CyclinD2 [1]
(Cell-free assay)
9 nM 11 nM 15 nM
体外研究

PD 0332991 对其他蛋白激酶包括EGFR, FGFR, PGFR, IR等没有抑制效果。 PD 0332991作用于Cdk4时是非ATP竞争性抑制剂。PD 0332991抑制MDA-MB-435乳腺癌细胞,IC50为66 nM,是由于Rb 在Ser780的磷酸化作用下降。PD 0332991抑制胸苷合并到Rb阳性的人类乳腺癌,结肠癌 肺癌,及白血病的DNA中,IC50值为4 nM到0.17 μM。PD 0332991作用于Rb阴性细胞没有抑制效果。PD 0332991作用于MDA-MB-453乳腺癌细胞和结肠-205细胞使细胞积累在G1期。[1]PD 0332991也有效作用于骨髓瘤5T33MM细胞,使细胞对Bortezomib敏感。[2]PD 0332991抑制luminalER-阳性和HER2-增强的乳腺癌细胞系,包括MDA-MB-175 ZR-75-30 CAMA-1 MDA-MB-134 HCC-202 UACC-893 等等。在这些细胞系中,PD 0332991增强Tamoxifen和Trastuzumab 的活性。在MCF7抗Tamoxifen细胞中,PD 0332991也增强tamoxifen 的敏感性。[3] 最新研究显示PD 0332991可以抑制恶性横纹肌样肿瘤(MRT)细胞系包括MP-MRT-AN, KP-MRT-RY, G401, KP-MRT-NS,且MRT细胞系对PD 0332991敏感性和p16表达呈负相关。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MOLM13 NVq2cXYzU2mwYYPlJGF{e2G7 MUGyOEBp MlPWTY5pcWKrdHnvckBw\iCFRFu0JIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gVoIheGixc4Doc5J6dGG2aX;uJJdqfGhiSVO1NEBw\iByLkCwNkDPxE1? MnnINlQ3PDFzMEO=
COLO205 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWq3NkBp NHLzbIJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3Onc4Pl[EBieyCrbnPvdpBwemG2aX;uJI9nKFt|SG30bJlucWSrbnWgbY51dyCGTlGge4l1cCCLQ{WwJI9nKDBwMEO2JO69VQ>? MoOzNlQ3PDFzMEO=
U937 NWjN[GFlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVW3NkBp MlvORY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{\XO|ZXSgZZMhcW6lb4Lwc5JifGmxbjDv[kBcO0ifdHj5cYllcW6nIHnueI8hTE6DIIfpeIghUUN3MDDv[kAxNjF2IN88US=> MYiyOFY1OTFyMx?=
MOLM13 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPCOVhIPzJiaB?= MlHFRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPT1zNNVMh[2WubIOgbIFz[m:{aX7nJGZNXDNiSWTEJI12fGGwdDDhd5Nme3OnZDDhd{BqdmOxcoDvdoF1cW:wIH;mJHs{UF22aIntbYRqdmViaX70c{BFVkFid3n0bEBKSzVyIH;mJFAvODl4IN88US=> NXXucm8zOjR4NEGxNFM>
MOLM13 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXNVZJKPzJiaB?= NUDVfIZqSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEB{d3KjZnXubYIuemW|aYP0ZY51KGi3bXHuJG1QVE1zMzDj[YxteyCjc4Pld5Nm\CCjczDpcoNwenCxcnH0bY9vKG:oIGuzTH11cHmvaXTpcoUhcW62bzDEUmEhf2m2aDDJR|UxKG:oIECuNFk3KM7:TR?= NV;VTmtDOjR4NEGxNFM>
MDA-MB-435 NIrES5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPsTHUzPCCq MV3JR|UxRTBwMU[g{txO NEDINpMyPThyMUizNS=>
K562 NWixfpRbS3m2b4TvfIlkKEG|c3H5 M1n1dVk3KGh? MmfESG1UVw>? MXLJR|UxRTJizszN NGrZcW8zPDRzN{W2Oi=>
DU145 MmDnR5l1d3SxeHnjJGF{e2G7 MVy5OkBp M2PFZWROW09? MYXJR|UxRTdwNTFOwG0> NFnrNZQzPDRzN{W2Oi=>
MDA-MB-231 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLoflV3OSEQvF2= MmPJNlQhcA>? MX;EUXNQ MXPD[YxtKGO7Y3zlJIFzemW|dDDhd5Nme3OnZDDhd{Bi[2O3bYXsZZRqd25iYYSgS|EheGijc3W= NVfBW4JQOjR2MUe1OlY>
MCF7 MlvaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXWzWWFPOSEQvF2= M2LJd|I1KGh? MlroSG1UVw>? NVvnXZc4S2WubDDjfYNt\SCjcoLld5Qh[XO|ZYPz[YQh[XNiYXPjeY12dGG2aX;uJIF1KEdzIIDoZZNm MkKxNlQ1OTd3Nk[=
MCF7 NGftdJJMcW6jc3WgRZN{[Xl? MofDOUDPxE1? M3LaXVI1KGh? MlvISG1UVw>? M2HHdWlvcGmkaYTpc44hd2ZicnXjc41jcW6jboSgR2RMPC:leXPsbY5FOSCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHKndHnuc4Jt[XO2b33hJJBpd3OyaH;yfYxifGmxbjDheEBU\XJ5OEC= Mn2zNlQ1OTd3Nk[=
MDA-MB-231 MnXIT4lv[XOnIFHzd4F6 MYK1JO69VQ>? NUe4RnZROjRiaB?= NYDHWll{TE2VTx?= NYiyb5d3UW6qaXLpeIlwdiCxZjDy[YNwdWKrbnHueEBETEt2L3P5Z4xqdkRzIHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZicnX0bY5w[myjc4TvcYEheGixc4Doc5J6dGG2aX;uJIF1KFOncke4NC=> MWiyOFQyPzV4Nh?=
MDA-MB-231 M2jKXWZ2dmO2aX;uJGF{e2G7 NXXEb49oOS1zMDFOwG0> MnzYNlQhcA>? M3WwcWROW09? M{\nXoRw\XNibn;0JIlv\HWlZTDhdI9xfG:|aYOgZZN{\XO|ZXSgZZMhWEGUUDDjcIVifmGpZR?= M1jX[FI1PDF5NU[2
MCF7 MWPGeY5kfGmxbjDBd5NigQ>? MoXNNU0yOCEQvF2= NWHTN401OjRiaB?= NVvBToJETE2VTx?= NEPJUW9ld2W|IH7veEBqdmS3Y3WgZZBweHSxc3nzJIF{e2W|c3XkJIF{KFCDUmCgZ4xm[X[jZ3W= NWTyTZd7OjR2MUe1OlY>
MDA-MB-231 MmTsSpVv[3Srb36gRZN{[Xl? MnWwNE42NTFizszN NI\lUXM1QCCq NEDJSGdFVVOR NHTaeW5p[XNibn:gR4VtdCCleXPs[UBienKnc4SgZZN{\XO|ZXSgZZMh[WOldX31cIF1cW:wIHH0JJN2[i2JMTDwbIF{\Q>? M{LtXlI1PDF5NU[2
MCF7 Mkm1SpVv[3Srb36gRZN{[Xl? M3qzbVAvPS1zIN88US=> NVvYWGhXPDhiaB?= NIT4[oRFVVOR MXHoZZMhdm9iQ3XscEBkgWOuZTDhdpJme3RiYYPz[ZN{\WRiYYOgZYNkfW23bHH0bY9vKGG2IIP1Zk1IOSCyaHHz[S=> M1XiUVI1PDF5NU[2
697 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTEdndTUUN3ME2xOFgvOzhibl2= NEnXRlVUSU6JRWK=
P12-ICHIKAWA Mnq0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fKOWlEPTB;OU[uNFQhdk1? MWHTRW5ITVJ?
NB69 M4O5SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHKTWM2OD1zNkGuPEBvVQ>? MmP6V2FPT0WU
EoL-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1O0UmlEPTB;MUi3MlI3KG6P M3rvW3NCVkeHUh?=
BHT-101 MnrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjpeHh[UUN3ME2xPVgvOjVibl2= NXTvPW9MW0GQR1XS
SK-NEP-1 NHP5XXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTJ{MD6wNkBvVQ>? NUPmcFFOW0GQR1XS
MHH-NB-11 MoLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTJ{MD6xPUBvVQ>? NHfJNGNUSU6JRWK=
AsPC-1 MkXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXiTHZKSzVyPUK1Nk42OyCwTR?= M1m3VnNCVkeHUh?=
ES1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrUVGRKSzVyPUK1Ok4zPSCwTR?= MlO3V2FPT0WU
LAMA-84 NFrYUWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjqT49lUUN3ME2yOVgvOTlibl2= NWTFV5RxW0GQR1XS
MOLT-16 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\oWZNKSzVyPUK1PE41QSCwTR?= NUWzSJpPW0GQR1XS
ES7 M3fMNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTJ5Mz6wPUBvVQ>? NX3GOplvW0GQR1XS
KY821 NYDzXo9XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXPTWM2OD1|MUSuNUBvVQ>? MlHJV2FPT0WU
RT-112 NU[5RXpHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvyOFY3UUN3ME2zNlEvODVibl2= M3PpeHNCVkeHUh?=
HL-60 M2\Bemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnvS2k3UUN3ME2zOFAvPjZibl2= MmHzV2FPT0WU
MOLT-4 MmDFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LGfmlEPTB;M{S1MlE{KG6P M2HpPXNCVkeHUh?=
KARPAS-45 NWDnd|ZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;PWYN6UUN3ME2zO|YvOTZibl2= M3iwW3NCVkeHUh?=
SK-N-AS MmTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlKxTWM2OD1|OEeuPFMhdk1? M2PxfHNCVkeHUh?=
CTB-1 M3nWSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTRyNT6wNkBvVQ>? NVu0NnhGW0GQR1XS
NKM-1 M1Ptc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3u2SmlEPTB;NEGxMlg6KG6P NIi3[5NUSU6JRWK=
HTC-C3 Mni1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnWR3NKSzVyPUSzNk46PSCwTR?= MUTTRW5ITVJ?
BE-13 Mn22S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LlXWlEPTB;NES0MlI4KG6P NXzzN4NTW0GQR1XS
KOSC-2 M1LUdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELDWVVKSzVyPUS2Ok46KG6P M3X2dnNCVkeHUh?=
NB14 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHDb4hqUUN3ME20PFMvPThibl2= NHWxO25USU6JRWK=
CAL-27 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrnXVJbUUN3ME20PVQvPTlibl2= NXvUcZQ5W0GQR1XS
H9 NF7EeYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTR7NT60N{BvVQ>? NXjseYtWW0GQR1XS
RS4-11 NEfje3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTVyND63N{BvVQ>? MWTTRW5ITVJ?
PA-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\1TWM2OD13MEmuPFYhdk1? M2fNZnNCVkeHUh?=
MV-4-11 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVO4UYJOUUN3ME21NVMvQDVibl2= Ml\YV2FPT0WU
OS-RC-2 NH\wOYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{Oy[mlEPTB;NUKxMlYzKG6P NV7STYNzW0GQR1XS
RPMI-8226 NGDh[G1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzWOopjUUN3ME21NlYvQDZibl2= Mm\TV2FPT0WU
HGC-27 M33WWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTV4ND65PUBvVQ>? M1PZRnNCVkeHUh?=
CHP-212 Mo\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3K1V2lEPTB;NUmzMlU6KG6P MnG1V2FPT0WU
NB10 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{Hs[mlEPTB;NUm5MlE5KG6P MoD3V2FPT0WU
HH MmfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlSyTWM2OD13OUmuOFMhdk1? NHnUV4ZUSU6JRWK=
EW-16 NI[0VVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHv5VHJKSzVyPU[wN{42OiCwTR?= M3ziV3NCVkeHUh?=
ES8 M4HyZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vxbGlEPTB;NkC1MlIyKG6P M{Lk[3NCVkeHUh?=
HAL-01 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTZyNT62O{BvVQ>? M{nrOXNCVkeHUh?=
A204 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPkS5BKSzVyPU[zN{46OSCwTR?= MkfPV2FPT0WU
MHH-PREB-1 NGLrPY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;kTWM2OD14M{[uPVkhdk1? NHSwNmhUSU6JRWK=
EM-2 NHHsXmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HTR2lEPTB;NkWwMlY1KG6P NF7GWm9USU6JRWK=
BV-173 NW\ndIFOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXS0T5ZVUUN3ME22OVIvPDhibl2= M{LQ[XNCVkeHUh?=
ONS-76 NF\LWoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXlTWM2OD14N{euPFIhdk1? M4rjcnNCVkeHUh?=
KM-H2 MlK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHUbplKSzVyPU[5OU42PCCwTR?= M4LNWXNCVkeHUh?=
D-263MG NEHpPWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDReIRKSzVyPUexO{4yOiCwTR?= MkHBV2FPT0WU
ES3 MkTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7rUGVjUUN3ME23NlgvQTNibl2= NVXWZ4lsW0GQR1XS
VA-ES-BJ NY\kUVkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4f4e2lEPTB;N{OyMlI4KG6P NFzpTFdUSU6JRWK=
NBsusSR MoHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vldWlEPTB;N{SyMlk6KG6P MYHTRW5ITVJ?
NCI-H520 NVHzOFlWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvWOGFkUUN3ME23OFYvPTJibl2= MVXTRW5ITVJ?
ES5 MlPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVWxR|NwUUN3ME23OVIvQCCwTR?= Ml\IV2FPT0WU
T-24 M3;iWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHkTWM2OD15N{iuO|Ehdk1? MmLQV2FPT0WU
SW962 M4jwO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPnXpFKSzVyPUiwPE43OyCwTR?= NYS3NIJsW0GQR1XS
EW-3 NH;rVFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFf6dmpKSzVyPUiwPE44PiCwTR?= MXXTRW5ITVJ?
RXF393 M3Tt[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3q0SmlEPTB;OEGyMlc6KG6P M{XYWHNCVkeHUh?=
U251 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXxfY9KSzVyPUixN{45QCCwTR?= M1Po[XNCVkeHUh?=
CAMA-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPjNWZKSzVyPUizN{46PCCwTR?= MV3TRW5ITVJ?
JVM-3 NWnaNot3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHpTWM2OD16NUGuO|ghdk1? Mn3xV2FPT0WU
COLO-800 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTh7Nz63PEBvVQ>? NWf5NJh7W0GQR1XS
OVCAR-5 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTlyMD6xJI5O NEDOSYVUSU6JRWK=
LB1047-RCC NXPsemdnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjqOnpbUUN3ME25NlcvPTZibl2= NHruZ4ZUSU6JRWK=
SW954 NH\rZmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm[xTWM2OD17MkmuOFEhdk1? MmezV2FPT0WU
J-RT3-T3-5 M4DWfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\WTWM2OD17M{[uNFYhdk1? Ml\sV2FPT0WU
Mewo MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjPco5xUUN3ME25N|YvPiCwTR?= MWLTRW5ITVJ?
NCI-H1770 NVLpO4R1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7jTWM2OD17NECuOVUhdk1? MWXTRW5ITVJ?
HO-1-N-1 M4XE[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{O4U2lEPTB;OU[yMlgyKG6P MmLDV2FPT0WU
HSC-3 MoDzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTl4Nj60PEBvVQ>? MUfTRW5ITVJ?
TYK-nu MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7CNYczUUN3ME25PVgvOjVibl2= M1rTZnNCVkeHUh?=
KYSE-150 MlXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7KV3FKSzVyPUGuNFAxPzZizszN NIr4[YJUSU6JRWK=
SN12C NIPrdXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;YTWM2OD1zLkCwPFc2KM7:TR?= NXz6OpFxW0GQR1XS
MOLT-13 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETFSWNKSzVyPUGuNFE1OjFizszN MnPxV2FPT0WU
TE-11 MnT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTFwMES4NVIh|ryP M2LJfXNCVkeHUh?=
DB MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2O5NGlEPTB;MT6wO|I4OyEQvF2= MlS4V2FPT0WU
CAL-39 NEnI[2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPVe2VQUUN3ME2xMlA4PTJ{IN88US=> Mn7iV2FPT0WU
A3-KAW M33j[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLVV29KSzVyPUGuNFg1ODhizszN NUSzdXhrW0GQR1XS
CHP-134 MlXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILtd|BKSzVyPUGuNVE5ODdizszN NVmxUGlyW0GQR1XS
TGW MnTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{mzcmlEPTB;MT6xNlM6PSEQvF2= NED5RnJUSU6JRWK=
QIMR-WIL M2PZT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHv5c2VKSzVyPUGuNVMyOzRizszN M1\QeXNCVkeHUh?=
NCI-SNU-1 M3;pcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\vdlFKSzVyPUGuNVY{PTRizszN NXnMPY5SW0GQR1XS
CGTH-W-1 NUjVT29mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXSwSGJpUUN3ME2xMlE4OTh4IN88US=> MmC0V2FPT0WU
MHH-ES-1 NF7WNIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTFwMUe5PFYh|ryP MkXDV2FPT0WU
LB2241-RCC MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4eyR2lEPTB;MT6xPFYzKM7:TR?= MWrTRW5ITVJ?
ML-2 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2S2[WlEPTB;MT6yNFc{PCEQvF2= MUPTRW5ITVJ?
COR-L23 NV\mUnpyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYSxNIJbUUN3ME2xMlIzQTN|IN88US=> NU[xUGhYW0GQR1XS
BFTC-905 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrHcY84UUN3ME2xMlI1OjZ5IN88US=> NXrBVGR[W0GQR1XS
Hs-578-T NUfNfJp5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETBSYFKSzVyPUGuNlU5OTdizszN NXPEUZBWW0GQR1XS
KG-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmS0TWM2OD1zLkK2Olg3KM7:TR?= NVq2cZpFW0GQR1XS
HEL NFqxUIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTFwMkmzN|gh|ryP M3zMWnNCVkeHUh?=
A549 NEf3d2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnK5TWM2OD1zLkK5N|k6KM7:TR?= NXj2cFVDW0GQR1XS
COLO-741 NGjzWWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\xNHlKSzVyPUGuN|IxQDlizszN NIrUTYpUSU6JRWK=
PC-3 NXu1WoY3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3L6e2lEPTB;MT6zOVIzOSEQvF2= M3;3N3NCVkeHUh?=
HOS NX21fIMzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rhU2lEPTB;MT6zOVI6PiEQvF2= M2qxN3NCVkeHUh?=
HT-1080 NXTYepN6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXwV41UUUN3ME2xMlM4PTF7IN88US=> NEDxZ3FUSU6JRWK=
TE-8 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3i0dWlEPTB;MT60NVc4PCEQvF2= NGXoOmpUSU6JRWK=
BHY MlyxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTFwNE[5NlMh|ryP NGrWfZFUSU6JRWK=
BB65-RCC M3jwfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTFwNUC1Nlgh|ryP MVjTRW5ITVJ?
HN MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTFwNUSwO|Eh|ryP NGP0[VFUSU6JRWK=
NCI-H441 NYn0cmoxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4S5XmlEPTB;MT61OFkxPyEQvF2= Mkm3V2FPT0WU
RPMI-8866 NWXKSIc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfPXYlKSzVyPUGuOVg2ODdizszN NVvaeFdiW0GQR1XS
CAL-62 Ml\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTFwNkC4OlIh|ryP MVrTRW5ITVJ?
MG-63 NELQNFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\reVZKSzVyPUGuOlE5OTNizszN M2LIUnNCVkeHUh?=
SK-LU-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTFwNkKxOVIh|ryP NHXXWplUSU6JRWK=
BCPAP MmizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3o[XJKSzVyPUGuOlY1PTdizszN Mn3EV2FPT0WU
22RV1 M{XKXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PYWmlEPTB;MT62O|g1OyEQvF2= NVXtZm1FW0GQR1XS
T47D M13Ye2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITYU|dKSzVyPUGuOlgxPjFizszN M2fV[HNCVkeHUh?=
MSTO-211H M{XxW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk[0TWM2OD1zLk[5OlA{KM7:TR?= NUjofYc1W0GQR1XS
DEL MlXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDFbXF7UUN3ME2xMlcxOjd|IN88US=> NXnOe2RjW0GQR1XS
H4 MkDnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLoW|M6UUN3ME2xMlc{OjF{IN88US=> M{XEfXNCVkeHUh?=
CAL-51 M{P5UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3L4cWlEPTB;MT63OFg2PSEQvF2= Mlf6V2FPT0WU
ABC-1 M17BNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\EZpJTUUN3ME2xMlc5PTh{IN88US=> NUHOVnZMW0GQR1XS
MZ2-MEL NHLtcXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHDTWM2OD1zLke5OVQzKM7:TR?= NWLZN3BEW0GQR1XS
YKG-1 M{mxdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYG0TWhvUUN3ME2xMlgyODZzIN88US=> M1PQ[HNCVkeHUh?=
KM12 MlTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\ZU2RbUUN3ME2xMlgyPjB{IN88US=> NXHQXHVpW0GQR1XS
L-363 NGracFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYSyd5ZFUUN3ME2xMlg4PDF{IN88US=> NH6wPJlUSU6JRWK=
KU812 NIPOfGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTFwOEmyPFIh|ryP MmLlV2FPT0WU
LOXIMVI MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTFwOUGyNlgh|ryP NWG3RmtbW0GQR1XS
G-401 MnLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTFwOUK0Nlgh|ryP M1rFV3NCVkeHUh?=
SW780 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XhVWlEPTB;MT65OlI1PiEQvF2= NVPpfllmW0GQR1XS
SW872 NI\WUHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYf0VW1vUUN3ME2xMlk5OzNizszN NYHwZYx6W0GQR1XS
NB7 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DCdWlEPTB;MT65PVMzOyEQvF2= M2\jdHNCVkeHUh?=
T98G Mnz5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXGeYpKSzVyPUKuNFA3PjZizszN MnPOV2FPT0WU
SW1710 MlzES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHviPIxKSzVyPUKuNFY6PDVizszN Mmf6V2FPT0WU
NCI-H1573 NWjOWXluT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3tcINRUUN3ME2yMlA4Ojl6IN88US=> NWHrcnZTW0GQR1XS
KE-37 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnftTWM2OD1{LkC4PVUyKM7:TR?= MWjTRW5ITVJ?
786-0 M{nVc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjvTWM2OD1{LkG1OFM6KM7:TR?= M134V3NCVkeHUh?=
SAS NV[xcJJVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorRTWM2OD1{LkKwN|c1KM7:TR?= NE\mU2FUSU6JRWK=
CAL-54 Mn\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPOTWM2OD1{LkKwOFE{KM7:TR?= NFntfW5USU6JRWK=
SF268 MnG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13RVGlEPTB;Mj6yN|EzOiEQvF2= NXLZTW5wW0GQR1XS
SW620 NXG0e28zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPaZXdKSzVyPUKuNlYyPjlizszN M3PHdnNCVkeHUh?=
MN-60 NUT0R5k6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTJwM{GwOkDPxE1? MoqwV2FPT0WU
EFO-27 Mnz3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rEOmlEPTB;Mj6zNlA2QCEQvF2= MUfTRW5ITVJ?
NCI-H747 NXHMNoFOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XnZmlEPTB;Mj6zNlE6QSEQvF2= M1jK[3NCVkeHUh?=
HCC2218 NV3VbXdPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTSTWM2OD1{LkO1N|c1KM7:TR?= NVHnVXlKW0GQR1XS
MIA-PaCa-2 NGfSZ2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnZTWM2OD1{LkO2OFM4KM7:TR?= Mki5V2FPT0WU
SJSA-1 NH\vOG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzVdZNKSzVyPUKuN|c4QTZizszN MnrIV2FPT0WU
RKO MnPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmf5TWM2OD1{LkO4OFk3KM7:TR?= MnTaV2FPT0WU
NB6 MlrUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PFb2lEPTB;Mj60NFM4PCEQvF2= MYLTRW5ITVJ?
ES4 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3qTWM2OD1{LkS1OFIzKM7:TR?= MnLGV2FPT0WU
EGI-1 NGHPPYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWX2e2NZUUN3ME2yMlQ3QDh|IN88US=> NEDqWIJUSU6JRWK=
CTV-1 NX3CR3ZIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTJwNUK3O|Mh|ryP NIHmVVZUSU6JRWK=
NCI-H1355 NYTlcIdmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M16xTGlEPTB;Mj61OVk2OSEQvF2= Mnv6V2FPT0WU
GT3TKB NVT1RoZ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Lw[2lEPTB;Mj61PVE6QSEQvF2= MYXTRW5ITVJ?
SK-HEP-1 NEnGfIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTJwNUmyOlYh|ryP NUfo[49EW0GQR1XS
GAMG MorGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTJwNUmzPVQh|ryP NYf2U402W0GQR1XS
SK-MES-1 M4TwOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLBOZVKSzVyPUKuOlE5ODNizszN MkToV2FPT0WU
RO82-W-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTJwNkKwOVch|ryP MV7TRW5ITVJ?
ECC10 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXQT49KSzVyPUKuO|AzODZizszN Mnr4V2FPT0WU
MCF7 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTJwN{G0OlQh|ryP M4i0ZXNCVkeHUh?=
D-283MED MmXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTJwN{K0N{DPxE1? NF\FNHVUSU6JRWK=
RPMI-7951 MmLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\ZNnhKSzVyPUKuO|U3QTRizszN M{jPOXNCVkeHUh?=
Ramos-2G6-4C10 NV\QeIpqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PvU2lEPTB;Mj63O|A6QSEQvF2= NEfaW3RUSU6JRWK=
KGN NXH4N4JlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\UXVZbUUN3ME2yMlgyQDh2IN88US=> MUXTRW5ITVJ?
NUGC-3 M3naZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlS3TWM2OD1{LkiyOVA2KM7:TR?= NUPtPGhqW0GQR1XS
NCI-H292 NYi4cGRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjhTWM2OD1{Lki1NFU{KM7:TR?= MYDTRW5ITVJ?
Becker NHezeIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jrOGlEPTB;Mj65OVg{OiEQvF2= Mlv0V2FPT0WU
NCI-H1299 Mkj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\2[Xc{UUN3ME2zMlA2OjZ|IN88US=> MYfTRW5ITVJ?
ETK-1 M1rISGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLDd4pKSzVyPUOuNFU1OyEQvF2= M1KydHNCVkeHUh?=
TK10 NVPQcYxTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjoXHJ7UUN3ME2zMlIxOTZ3IN88US=> MYDTRW5ITVJ?
VMRC-RCZ M1\Re2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTNwM{[0PFgh|ryP NFj6SVhUSU6JRWK=
YH-13 MmD5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jXZmlEPTB;Mz60OFA4QSEQvF2= MXPTRW5ITVJ?
DU-145 NH;m[o9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjhem9KSzVyPUOuOFYzPjlizszN MYDTRW5ITVJ?
SW1088 NInCUWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTNwNEe0O{DPxE1? M4frcHNCVkeHUh?=
HOP-92 M3fSeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWX3W41wUUN3ME2zMlUxOzR{IN88US=> MnrUV2FPT0WU
KP-N-YS MljPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHKfFJmUUN3ME2zMlYzOTN7IN88US=> NUm1WXFIW0GQR1XS
NCI-H460 Ml\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2e1V2lEPTB;Mz62Olc{KM7:TR?= M1PnUnNCVkeHUh?=
U-2-OS NXrtUmNXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUflPYFoUUN3ME2zMlczPTN3IN88US=> MYrTRW5ITVJ?
A101D M2TJc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGOzVndKSzVyPUOuO|Y6OzZizszN NEXHeYdUSU6JRWK=
MDA-MB-231 NWf3SoVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYL0N5JYUUN3ME2zMlgyQTVzIN88US=> NFr6OYhUSU6JRWK=
IST-MES1 NHzoWVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7lTWM2OD1|LkizNkDPxE1? NFrsXY9USU6JRWK=
COR-L105 MmL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTRwMEG4JO69VQ>? MVHTRW5ITVJ?
NCI-H1437 M2fqSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3z2R2lEPTB;ND6wNlMxOiEQvF2= NHe5TJRUSU6JRWK=
CAL-85-1 MoCyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVH6PJhsUUN3ME20MlAzPDZzIN88US=> Mlz0V2FPT0WU
MZ1-PC Ml;1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnqwTWM2OD12LkG4OVU3KM7:TR?= NXTDUVJxW0GQR1XS
VM-CUB-1 NF;nNWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnPfIdRUUN3ME20MlMyOjh2IN88US=> NXf5d5lpW0GQR1XS
CHL-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjSRohKSzVyPUSuN|IyPjlizszN NY\nRWhuW0GQR1XS
MDA-MB-361 NFK1eXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTRwM{OxOVMh|ryP MlLzV2FPT0WU
NCI-H661 NEPkcYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTRwNUCwPVIh|ryP M4m5NXNCVkeHUh?=
EW-11 M13uNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\Lb2lEPTB;ND61NlI{OSEQvF2= MWrTRW5ITVJ?
BEN M1zUeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTRwNUK4NVUh|ryP MlfSV2FPT0WU
BFTC-909 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\NT3RnUUN3ME20MlU3Ojd3IN88US=> NGXw[4pUSU6JRWK=
NCI-H2087 NUe0THFUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLDOppLUUN3ME20MlU5OTZ2IN88US=> M3G4OXNCVkeHUh?=
RVH-421 NIHLTHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXreHFKSzVyPUSuOlY3QSEQvF2= MYHTRW5ITVJ?
P30-OHK NVj6[IJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnWTWM2OD12Lk[4NFA5KM7:TR?= Ml[wV2FPT0WU
NCI-H28 NYD1Z2NrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjxNZpKSzVyPUSuPFE3PjFizszN M3\iTXNCVkeHUh?=
ES6 NHPu[ZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkKyTWM2OD12LkizNFE3KM7:TR?= M37yfHNCVkeHUh?=
769-P M{j6fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGS1e3FKSzVyPUSuPFU6OjZizszN M3jOUHNCVkeHUh?=
OE33 NXHGW3BnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTRwOEixOlEh|ryP NWXifJlqW0GQR1XS
SW982 NYWyNGVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3XZYlDUUN3ME20Mlk2ODZzIN88US=> NWHWRYh{W0GQR1XS
A388 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPnU4tKSzVyPUWuNFI6QDNizszN M4nWe3NCVkeHUh?=
TI-73 NIfFbFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWOyOGVqUUN3ME21MlA3OTl2IN88US=> NV7ISZZbW0GQR1XS
HCT-116 Ml;ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTVwMEm4PFkh|ryP MUfTRW5ITVJ?
HuP-T3 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorZTWM2OD13LkG4O|A6KM7:TR?= MkHaV2FPT0WU
G-402 NHrQdFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vPcWlEPTB;NT6xPVQyPiEQvF2= MnWwV2FPT0WU
NCI-H1792 M1H2fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHOTWM2OD13LkK0OlIzKM7:TR?= MnTQV2FPT0WU
NCI-H209 M2fEPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHniNlVKSzVyPUWuNlU6PDJizszN M{jER3NCVkeHUh?=
NCI-H1650 NGjnTY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfteJZKSzVyPUWuN|A3OzRizszN NXqxfoI4W0GQR1XS
LCLC-97TM1 NYPHWo1ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmT1TWM2OD13LkOxPFA5KM7:TR?= MmXUV2FPT0WU
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RCC10RGB MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jIPGlEPTB;MUiuNVY6PyEQvF2= M{jaOnNCVkeHUh?=
HD-MY-Z M{fGfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nqN2lEPTB;MUiuNlI2PCEQvF2= NYL3fY46W0GQR1XS
A427 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfuR49KSzVyPUG4MlUxQTRizszN NWC0[G56W0GQR1XS
HCC2998 M122SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILxSVlKSzVyPUG4MlYxPTFizszN NH65[o1USU6JRWK=
EPLC-272H NVPxO|FKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTF7LkC0N|Qh|ryP MX;TRW5ITVJ?
C32 M{TB[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M32x[2lEPTB;MUmuNFQ2KM7:TR?= M{PxZnNCVkeHUh?=
UMC-11 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPSVWJKSzVyPUG5MlIyOjNizszN Mmq2V2FPT0WU
CaR-1 NX;jO3BkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTF7Lk[4NFQh|ryP M1rke3NCVkeHUh?=
KYSE-410 M{S3Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2m1fWlEPTB;MUmuPVE{QSEQvF2= NYnDWItQW0GQR1XS
HuCCT1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTJyLk[yPVQh|ryP M1v6TXNCVkeHUh?=
LB996-RCC Mlm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PjVmlEPTB;MkCuO|E3QCEQvF2= MlfLV2FPT0WU
KYSE-70 NH3zNIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{Da[GlEPTB;MkCuPFA2QSEQvF2= MXPTRW5ITVJ?
CAL-72 M3\qbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPvcYpKSzVyPUKwMlkyPSEQvF2= M330ZnNCVkeHUh?=
Capan-2 NUnyRoI6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHMdHpKSzVyPUKxMlA1OTNizszN NID0T2pUSU6JRWK=
PANC-08-13 NVWwPXZ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;oPHJKSzVyPUKxMlI2OTVizszN M3nxXHNCVkeHUh?=
SBC-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fIOGlEPTB;MkGuN|A5OSEQvF2= NIrTWnFUSU6JRWK=
MFM-223 NUnTU4JzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTJzLkOzOFIh|ryP M4LMTnNCVkeHUh?=
BB49-HNC NX;IR5lDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTJzLkW3NVYh|ryP MYDTRW5ITVJ?
SH-4 MmDvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PLfmlEPTB;MkGuOlYyQCEQvF2= Mn7iV2FPT0WU
HuO9 NUPyZYwyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDuOldoUUN3ME2yNU46QDJ3IN88US=> MoPJV2FPT0WU
AM-38 NUSwdI5YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTJ{LkC0PFUh|ryP M2myXHNCVkeHUh?=
A431 NHW4ZoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnOyTWM2OD1{Mz6yNVE6KM7:TR?= M1jXbnNCVkeHUh?=
YAPC MoLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXSzSpRyUUN3ME2yN{4zPjVzIN88US=> MonhV2FPT0WU
LU-139 MnfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLXTHJKSzVyPUKzMlQ5ODlizszN M3vjb3NCVkeHUh?=
HEC-1 MoDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTJ|LkS5N|ch|ryP Ml;vV2FPT0WU
SCC-25 NXTaOI86T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Ti[mlEPTB;MkSuN|AxPiEQvF2= Mn;LV2FPT0WU
HT-29 NHXOfmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlO0TWM2OD1{ND6zPFI{KM7:TR?= M1z1b3NCVkeHUh?=
PC-14 NVLn[GZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TzfmlEPTB;MkSuOlU4OSEQvF2= NUP1XVBEW0GQR1XS
Calu-6 MlvyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzudlBKSzVyPUK1MlUxPzFizszN M4j1cHNCVkeHUh?=
SJRH30 NGfkNW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTJ3Lk[0PVYh|ryP NV32UXRCW0GQR1XS
ChaGo-K-1 NXK3doV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjDZ2t7UUN3ME2yOk4yPjJ7IN88US=> M4r6NHNCVkeHUh?=
IA-LM NUnaZmVVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rrZmlEPTB;Mk[uN|Y1PSEQvF2= NHL2bYZUSU6JRWK=
GP5d NIPIPY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIn1T4ZKSzVyPUK2MlQ1QTFizszN MWPTRW5ITVJ?
NCI-H2291 NFHaNHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfSWYRJUUN3ME2yOk43PTRzIN88US=> M4n1U3NCVkeHUh?=
BALL-1 M2PIfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moj2TWM2OD1{Nj65N|k4KM7:TR?= NVvkfVNGW0GQR1XS
HCC1954 M{jGNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTJ4Lkm4NFgh|ryP Mn;vV2FPT0WU
NCI-H2452 NIr2VnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTJ5LkSxOlMh|ryP MmXSV2FPT0WU
LU-99A M1OxdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF:x[HhKSzVyPUK3MlU2QDJizszN M4HyR3NCVkeHUh?=
NTERA-S-cl-D1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzzRm5KSzVyPUK3MlczQTlizszN MUnTRW5ITVJ?
PANC-10-05 NXX6XYo4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTJ5Lke3O|Uh|ryP NXHhNYs3W0GQR1XS
NCI-H2405 NXrkNXFOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfGRmZsUUN3ME2yO{46Ozh5IN88US=> MXjTRW5ITVJ?
MDA-MB-415 M{nvdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXQTWM2OD1{OD60NVM4KM7:TR?= NU\qdYZtW0GQR1XS
NCI-H2342 MnXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjNN4hxUUN3ME2yPE42OjhzIN88US=> NGLNUldUSU6JRWK=
TGBC24TKB MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTJ6LkexNVch|ryP NIXjR3lUSU6JRWK=
LU-134-A NV;GbZBNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7XTWM2OD1{OD65NlYyKM7:TR?= M{K0ZXNCVkeHUh?=
SCC-4 NFOwcXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jl[GlEPTB;M{GuNFQ6PCEQvF2= MXnTRW5ITVJ?
Saos-2 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13lZmlEPTB;M{GuPVMxPiEQvF2= M3vKbHNCVkeHUh?=
RERF-LC-MS Mn\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPUTWM2OD1|Mj64NlMyKM7:TR?= MUDTRW5ITVJ?
M14 M2jMR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTN{Lkm3OlQh|ryP Mn;BV2FPT0WU
HPAF-II NGLjV49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\HNGlEPTB;M{OuOVAyOSEQvF2= MnfBV2FPT0WU
NCI-H1755 NIH6SWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHqxb2NKSzVyPUO0MlM{ODVizszN NU\FbXNyW0GQR1XS
D-392MG NVrISW93T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XMd2lEPTB;M{WuPFY4PCEQvF2= MW\TRW5ITVJ?
A704 NYTo[2ZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fm[WlEPTB;M{[uNFQzPyEQvF2= NH7xfndUSU6JRWK=
CP50-MEL-B MonRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTN4LkG5NVEh|ryP NFiwWmNUSU6JRWK=
EW-18 NHj6OGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETLdZhKSzVyPUO2MlQ2OiEQvF2= NXXLfXpXW0GQR1XS
WM-115 NFPtR5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TFOmlEPTB;M{[uPFA6QSEQvF2= M2n3PXNCVkeHUh?=
LU-65 NFfXRoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPmempNUUN3ME2zO{4yPDF5IN88US=> MXvTRW5ITVJ?
NCI-H1563 NYi4Tol[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV60eHJ2UUN3ME2zO{4zPDh2IN88US=> MlLwV2FPT0WU
DBTRG-05MG NFy2doVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLISo9XUUN3ME2zPE4xPjlzIN88US=> MWHTRW5ITVJ?
NCI-H630 NVXzZ4FNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTN6LkS3NVQh|ryP M1L2NXNCVkeHUh?=
NCI-H1155 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjWTWM2OD1|OT6yOFIh|ryP NHjGXXVUSU6JRWK=
OVACR-3 Mle3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE[5[XBKSzVyPUO5MlkyQTVizszN M1PvcHNCVkeHUh?=
OAW-42 Mlj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DlVmlEPTB;NECuOFI2QCEQvF2= M2HGNXNCVkeHUh?=
JVM-2 NF2zeHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7XOXFKSzVyPUSxMlI1OTVizszN Mn7lV2FPT0WU
C3A NHnofFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGK4V4xKSzVyPUSxMlM1PDdizszN MnfEV2FPT0WU
HT55 MmrRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPibmhKSzVyPUSyMlI5PDFizszN M1jvcXNCVkeHUh?=
OVCAR-4 NYq5V5p4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\ySZBKSzVyPUSyMlI6PzRizszN MX7TRW5ITVJ?
MEG-01 M1Lmcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHf2[mlKSzVyPUSyMlQ3OTZizszN MVvTRW5ITVJ?
NCI-H82 M4npNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTGfnlKSzVyPUSzMlk5QTJizszN MoTZV2FPT0WU
JEG-3 MmLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTR2Lkm0O{DPxE1? M17F[XNCVkeHUh?=
BPH-1 NU\3VpJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVO3TWxuUUN3ME20Ok4{QTl6IN88US=> NU\BVGNpW0GQR1XS
MPP-89 M1jPcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXOR|NyUUN3ME20O{4zQDl6IN88US=> NYLpPFROW0GQR1XS
ALL-PO MkLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTR5LkSxPFgh|ryP NGfTPJNUSU6JRWK=
HT NWPpTlBzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfvTWM2OD12Nz60PVIh|ryP MnKwV2FPT0WU
NCI-H2347 NXLiZ41vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTR6LkC3NVUh|ryP M1fMSHNCVkeHUh?=
A2780 M3r3RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPHTWM2OD12OT60NlI5KM7:TR?= NHnJdoVUSU6JRWK=
KARPAS-299 M1v4VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHuzTW9KSzVyPUS5MlUyOTlizszN NFjRNVhUSU6JRWK=
NCI-H1651 MlLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHNSnllUUN3ME20PU45QDJzIN88US=> NU\FR2tuW0GQR1XS

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
RB1 (pT821) / RB1 (pS780) / RB1 / CDK6 / CCND2 / RUNX1 / ETO; 

PubMed: 30300583     


Immunoblots showing dose-dependent impact of 72 hr palbociclib treatment on indicated protein levels in Kasumi-1 and SKNO-1 cells.

pRb(S807, 811) / CDK4 / CDK6 / PARP; 

PubMed: 28453226     


Effects of palbociclib on CDK4/6-Rb pathway. HCC cells were treated with different doses of palbociclib for 24 h, and then, the cells were subjected to western blot analysis. CF, cleaved fragment. 

LC3-I / LC3-II; 

PubMed: 28453226     


Palbociclib increases LC3-II amount in a dose-dependent manner in HCC cell lines. 

pAMPKα(T172) / pULK1(S317); 

PubMed: 28453226     


Dose-dependent response of palbociclib on AMPK-related molecules. HCC cells were treated with different concentrations of palbociclib for 24 h. The phosphorylation of the indicated proteins was determined by western blotting. 

SMAD2 (pS255); 

PubMed: 30343527     


T47D cells were treated with indicated concentrations of palbociclib for 24 h to evaluate substrate phosphorylation.

30300583 28453226 30343527
Growth inhibition assay
Cell viability; 

PubMed: 29670090     


Cell viability was determined by MTT assays after palbociclib exposure for 2, 4, and 6 days. The cell cycle of SYO-1 and Fuji cells was assessed after exposure to palbociclib (1 µM) for 24 h by flow cytometry analysis.

29670090
Immunofluorescence
SAHF/ATRX; 

PubMed: 26988987     


DAPI staining for senescence-associated heterochromatic foci (SAHF, left panel) and ATRX staining (right panel) in 1205Lu cells +/− palbociclib for 8 days. 

LC3B; 

PubMed: 28453226     


LC3B immunofluorescence in palbociclib‐treated Hep3B cells. Arrowheads indicate LC3-positive autophagosomes. Nuclei were counterstained with DAPI (blue).

26988987 28453226
ELISA
PGE2; 

PubMed: 26540629     


The supernatant of control and 7.5 μM palbociclib-treated cells was collected and stored at −80°C. PGE2 secretion was detected using ELISA.

26540629
体内研究 150 mg/kg PD 0332991处理 MDA-MB-435移植瘤完全抑制肿瘤。在多种人类肿瘤移植瘤中,PD 0332991也显示广谱抗癌活性,通过除去血管中p-Rb和增殖Marker Ki-67,且调节基因使其处于E2F转录水平控制。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

- 合并

Cdk实验:

PD0332991溶解在DMSO中。在96孔板上进行CDK 实验。通过杆状病毒感染,所有的CDK-cyclin 激酶复合体 在昆虫细胞中表达。实验底物为与GST融合的一段pRb。每孔体积为0.1 ml,包含:终浓度为20 mm Tris-HCl(pH 为7.4), 50 mmNaCl, 1 mm二硫苏糖醇, 10 mmMgCl2, 25 μm ATP (用于CDK4-cyclin D1, CDK6-cyclin D2,和CDK6-cyclin D3)或12 μm ATP (用于CDK2-cyclin E, CDK2-cyclin A, 和CDC2-cyclin B),0.25 μCi [γ-32P]ATP, 20 ng 酶, 1 μg GST·RB-Cterm, 及PD 0332991 (0.001-0.1μM)。除了[γ-32P]ATP的所有混合物加到孔中,放在搅拌器上搅拌2分钟。加入 [γ-32P]ATP开始反应, 在25 oC下温育15分钟。加入0.1 ml 20% 三氯乙酸终止反应, 在4 oC维持至少1小时,使底物沉淀。用0.2 ml 10%三氯乙酸冲洗5次,用β-计数器板测定掺入的放射性。
细胞实验:

[1]

- 合并
  • Cell lines: MDA-MB-435, ZR-75-1, T-47D, MCF-7, H1299, Colo-205, MDA-MB-468, H2009, CRRF-CEM,和K562细胞
  • Concentrations: 0.01-1 μM
  • Incubation Time: 24小时
  • Method:

    肿瘤细胞包括MDA-MB-435, ZR-75-1, T-47D, MCF-7, H1299, Colo-205, MDA-MB-468, H2009, CRRF-CEM,及K562按每孔2×104个细胞接种在96孔板上,温育过夜。加入PD 0332991 (0.01-1 μM) ,37oC温育24小时。每孔加入[14C]胸甘(0.1 μCi) ,进行同位素示踪,持续72小时。用β-计数器板测定掺入的放射性。


    (Only for Reference)
动物实验:

[1]

- 合并
  • Animal Models: 携带晚期人类肿瘤移植瘤,包括结肠-205, MDA-MB-435 乳腺癌, SF-295 恶性胶质瘤, ZR-75-1 乳腺癌, PC-3 前列腺癌, H125 肺癌, SW-620结肠癌, H23肺癌,及MDA-MB-468 乳腺癌 (Rb 阴性)的SCID鼠
  • Formulation: 溶解在乳酸钠buffer(50 mM, pH 4.0)中
  • Dosages: 0-150 mg/kg
  • Administration: 口服饲喂
    (Only for Reference)

溶解度 (25°C)

体外 Water 30 mg/mL (61.98 mM)
DMSO 3 mg/mL warmed (6.19 mM)
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
Saline
6 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 483.99
化学式

C24H29N7O2.HCl

CAS号 827022-32-2
储存条件 粉状
溶于溶剂
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03870919 Not yet recruiting Drug: Palbociclib|Other: locoregional treatment Breast Cancer Stage IV|Radiotherapy|Surgery UNICANCER|Pfizer October 15 2019 Not Applicable
NCT03900884 Not yet recruiting Drug: Venetoclax|Drug: Palbociclib|Drug: Letrozole Breast Neoplasm Female Peter MacCallum Cancer Centre Australia September 2019 Phase 1
NCT03844997 Recruiting Drug: Palcociclib|Drug: CPX-351 Acute Myeloid Leukemia|AML Aziz Nazha|Case Comprehensive Cancer Center May 31 2019 Phase 1|Phase 2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID