Palbociclib (PD-0332991) HCl

Pfizer辉瑞授权 目录号:S1116

Palbociclib (PD-0332991) HCl Chemical Structure

Molecular Weight(MW): 483.99

Palbociclib (PD-0332991) HCl是一种高度选择性的CDK4/6抑制剂,无细胞试验中IC50分别为11 nM/16 nM。它对CDK1/2/5,EGFR,FGFR,PDGFR,InsR等没有抑制活性。Phase 3。

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RMB 902.49 现货
RMB 1406.17 现货
RMB 4670.26 现货
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客户使用该产品的9个实验数据:

  • PD-0332991 causes inhibition of proliferation of EAC cells in a dose-dependent manner. Western blots showing the phosphorylation status of pRB at Ser780 and Ser795 after incubation with 125 nmol/L PD-0332991 for 24 and 72 hours. Reduction in cyclin A expression and the expression of RB2 (p130) tumor suppressor 72 hours after PD-0332991 treatment are shown (bottom). Total pRB (RB1) and actin are loading controls and T293 cell lysate (293) is a positive control for total pRB and phospho-pRB (Ph-RB). E, anchorage-independent growth of the 3 cell lines in the presence or absence (Cnt) of 125 nmol/L PD-0332991 for 3 weeks.

    Clin Cancer Res 2011 17(13), 4513-22. Palbociclib (PD-0332991) HCl purchased from Selleck.

    b, c MelJuso cells were treated for 12–48 h with 1 µM Selumetinib or 5 µM Palbociclib and the cells were fixed, stained with propidium iodide and cell cycle distribution was determined by flow cytometry (b) and whole cell extracts were fractionated by SDS-PAGE, transferred onto PVDF membrane and immuno-blotted with the indicated antibodies (c). Data is from a single experiment representative of three separate experiments with similar results. The data in (b) are mean ± S.D. from a single experiment with three replicate dishes of cell per data point; similar results were obtained in two additional experiments

    Cell Mol Life Sci, 2016, 73(4):883-900. Palbociclib (PD-0332991) HCl purchased from Selleck.

  • (A) Percentage of DN3a cells in S-phase (as gated on DAPI profile) from control (Zfp36l1/2fl/fl) and Zfp36l1/2fl/fl; CD2Cre (DCKO) mice, after 1 d of treatment with vector or palbociclib (drug).

    J Immunol, 2016, 197(7):2673-85. Palbociclib (PD-0332991) HCl purchased from Selleck.

     

    Patient tumor cell sensitivity to combinatorial treatment with histone deacetylase (HDAC)/cyclin-dependent kinase (CDK) inhibitors in 3-D culture. The effect of each drug or drug combination was assessed by fluorescent dye to identify live (green) and dead cells (red). Cells from breast reduction patients were used as non-cancer control in the assay.

    Pharmacogenomics J 2013 13(1), 94-104. Palbociclib (PD-0332991) HCl purchased from Selleck.

  • The expression of respective proteins in CDK4/6-Rb-apoptosis pathway in cells was examined by Western blot after 3 days of palbociclib treatment.

    Biochim Biophys Acta, 2018, 1864(5 Pt A):1573-1582. Palbociclib (PD-0332991) HCl purchased from Selleck.

     

    Cdk4 is upregulated in ARMS and mMSCs transfected with PAX7-FKHR fusion gene (MP7F), and can be specifi cally inhibited. D: IF results showing overexpression of cdk4 in MP7F cells compared to parental mMSCs and reduced expression of cdk4 after treatment of MP7F cells with the cdk4 inhibitor, PD-0332991. E: IF results showing MyoD1 expression in parental mMSCs cells, and MP7F cells untreated and after treatment with the cdk4 inhibitor, PD-0332991.

    Clin Transl Oncol 2012 14(3), 197-206 . Palbociclib (PD-0332991) HCl purchased from Selleck.

  • WM3734 melanoma cells were treated by PD-0332991 for 36 hours; melanoma cells treated by Doxorubicin (DXR)  at 0.5 μM is included as a control.

     

     

    Dr. Gao Zhang of University of Pennsylvania. Palbociclib (PD-0332991) HCl purchased from Selleck.

    Serum-deprived T98G glioma cells are restimulated with serum(FBS) with or without 1 μΜ PD-0332991.

     

     

    Dr. Sabine Paternot and Dr Pierre Roger of IRIBHM, ULB, Brussels. Palbociclib (PD-0332991) HCl purchased from Selleck.

  • P16INK4A knockdown in INK4A/ARF-wt human glioma cell LN319 potentiates PDGF-Apromoted anchorage-dependent growth in vitro. Soft agar growth of Ink4a/Arf-deficient mAst and LN444 cells treated with PD0332991. (A) IB analysis. (B) Quantification of soft agar assays. β-actin was used as a loading control in all IB experiments. Data are presented as mean ± s.d. and representative of two independent experiments. **, P < 0.01; ***, P < 0.001

    Dr. Kun-Wei Liu from University of Pittsburgh. Palbociclib (PD-0332991) HCl purchased from Selleck.

产品安全说明书

CDK抑制剂选择性比较

生物活性

产品描述 Palbociclib (PD-0332991) HCl是一种高度选择性的CDK4/6抑制剂,无细胞试验中IC50分别为11 nM/16 nM。它对CDK1/2/5,EGFR,FGFR,PDGFR,InsR等没有抑制活性。Phase 3。
特性 PD-0332991作为有应用前景的工具测定CDK激酶是否具有明显的治疗价值。
靶点
CDK4/CyclinD3 [1]
(Cell-free assay)
CDK4/CyclinD1 [1]
(Cell-free assay)
CDK6/CyclinD2 [1]
(Cell-free assay)
9 nM 11 nM 15 nM
体外研究

PD 0332991 对其他蛋白激酶包括EGFR, FGFR, PGFR, IR等没有抑制效果。 PD 0332991作用于Cdk4时是非ATP竞争性抑制剂。PD 0332991抑制MDA-MB-435乳腺癌细胞,IC50为66 nM,是由于Rb 在Ser780的磷酸化作用下降。PD 0332991抑制胸苷合并到Rb阳性的人类乳腺癌,结肠癌 肺癌,及白血病的DNA中,IC50值为4 nM到0.17 μM。PD 0332991作用于Rb阴性细胞没有抑制效果。PD 0332991作用于MDA-MB-453乳腺癌细胞和结肠-205细胞使细胞积累在G1期。[1]PD 0332991也有效作用于骨髓瘤5T33MM细胞,使细胞对Bortezomib敏感。[2]PD 0332991抑制luminalER-阳性和HER2-增强的乳腺癌细胞系,包括MDA-MB-175 ZR-75-30 CAMA-1 MDA-MB-134 HCC-202 UACC-893 等等。在这些细胞系中,PD 0332991增强Tamoxifen和Trastuzumab 的活性。在MCF7抗Tamoxifen细胞中,PD 0332991也增强tamoxifen 的敏感性。[3] 最新研究显示PD 0332991可以抑制恶性横纹肌样肿瘤(MRT)细胞系包括MP-MRT-AN, KP-MRT-RY, G401, KP-MRT-NS,且MRT细胞系对PD 0332991敏感性和p16表达呈负相关。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MOLM13 M4rqOmtqdmG|ZTDBd5NigQ>? M2n1dVI1KGh? Mln5TY5pcWKrdHnvckBw\iCFRFu0JIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gVoIheGixc4Doc5J6dGG2aX;uJJdqfGhiSVO1NEBw\iByLkCwNkDPxE1? M1;SNlI1PjRzMUCz
COLO205 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUe3NkBp MkTnRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{\XO|ZXSgZZMhcW6lb4Lwc5JifGmxbjDv[kBcO0ifdHj5cYllcW6nIHnueI8hTE6DIIfpeIghUUN3MDDv[kAxNjB|NjFOwG0> NXv3NJZpOjR4NEGxNFM>
U937 NGDTXFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPUO|IhcA>? M2nhSmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2W|c3XkJIF{KGmwY3;ydI9z[XSrb36gc4YhYzOKXYTofY1q\GmwZTDpcpRwKESQQTD3bZRpKEmFNUCgc4YhOC5zNDFOwG0> NXHmRmpSOjR4NEGxNFM>
MOLM13 Mn\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrRO3pnPzJiaB?= M1OzPWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTV;MUVE{KGOnbHzzJIhiemKxcnnu[{BHVFR|IFnUSEBufXSjboSgZZN{\XO|ZXSgZZMhcW6lb4Lwc5JifGmxbjDv[kBcO0ifdHj5cYllcW6nIHnueI8hTE6DIIfpeIghUUN3MDDv[kAxNjB7NjFOwG0> NVTzN3A{OjR4NEGxNFM>
MOLM13 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjtUI1kPzJiaB?= NWLYfGZuSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEB{d3KjZnXubYIuemW|aYP0ZY51KGi3bXHuJG1QVE1zMzDj[YxteyCjc4Pld5Nm\CCjczDpcoNwenCxcnH0bY9vKG:oIGuzTH11cHmvaXTpcoUhcW62bzDEUmEhf2m2aDDJR|UxKG:oIECuNFk3KM7:TR?= NF\lSVQzPDZ2MUGwNy=>
MDA-MB-435 M{DESGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUOyOEBp NXq0d3lCUUN3ME2wMlE3KM7:TR?= M{CzfVE2QDBzOEOx
K562 NHz6d5REgXSxdH;4bYMhSXO|YYm= MlPuPVYhcA>? M{P2fGROW09? NYjybINmUUN3ME2yJO69VQ>? MVSyOFQyPzV4Nh?=
DU145 MU\DfZRwfG:6aXOgRZN{[Xl? MkLzPVYhcA>? MVPEUXNQ NF3lO3ZKSzVyPUeuOUDPxE1? MmXWNlQ1OTd3Nk[=
MDA-MB-231 MkfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnv3NUDPxE1? MX:yOEBp NFXMWY1FVVOR NHS1V2FE\WyuIHP5Z4xmKGG{cnXzeEBie3Onc4Pl[EBieyCjY3P1cZVt[XSrb36gZZQhTzFicHjhd4U> Mlj5NlQ1OTd3Nk[=
MCF7 NYW1UpZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXv2VnpvOSEQvF2= MVmyOEBp MnqwSG1UVw>? MWnD[YxtKGO7Y3zlJIFzemW|dDDhd5Nme3OnZDDhd{Bi[2O3bYXsZZRqd25iYYSgS|EheGijc3W= NHTjOZIzPDRzN{W2Oi=>
MCF7 M1K3RmtqdmG|ZTDBd5NigQ>? MVW1JO69VQ>? NVzFbHpyOjRiaB?= Ml\ySG1UVw>? MUfJcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IFPET|Qw[3mlbHnuSFEh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBz\XSrbn;icIF{fG:vYTDwbI9{eGixconsZZRqd25iYYSgV4VzPzhy MmXYNlQ1OTd3Nk[=
MDA-MB-231 MnLmT4lv[XOnIFHzd4F6 MljnOUDPxE1? MX6yOEBp MYTEUXNQ M1;WOWlvcGmkaYTpc44hd2ZicnXjc41jcW6jboSgR2RMPC:leXPsbY5FOSCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHKndHnuc4Jt[XO2b33hJJBpd3OyaH;yfYxifGmxbjDheEBU\XJ5OEC= MlXDNlQ1OTd3Nk[=
MDA-MB-231 MWPGeY5kfGmxbjDBd5NigQ>? NUH6copkOS1zMDFOwG0> NX[4W3Q2OjRiaB?= MWfEUXNQ NVzGVHAx\G:nczDuc5QhcW6mdXPlJIFxd3C2b4Ppd{Bie3Onc4Pl[EBieyCSQWLQJINt\WG4YXfl M376fFI1PDF5NU[2
MCF7 MkPoSpVv[3Srb36gRZN{[Xl? MX:xMVExKM7:TR?= NIj4[I8zPCCq MYDEUXNQ MnrX[I9meyCwb4SgbY5lfWOnIHHwc5B1d3OrczDhd5Nme3OnZDDhd{BRSVKSIHPs[YF3[Wen M1[5UlI1PDF5NU[2
MDA-MB-231 MUfGeY5kfGmxbjDBd5NigQ>? NGjySI8xNjVvMTFOwG0> NVPIbHNxPDhiaB?= MmDoSG1UVw>? M37ESIhieyCwbzDD[YxtKGO7Y3zlJIFzemW|dDDhd5Nme3OnZDDhd{Bi[2O3bYXsZZRqd25iYYSgd5VjNUdzIIDoZZNm M3y3PVI1PDF5NU[2
MCF7 NFzGNHhHfW6ldHnvckBCe3OjeR?= M1nYWlAvPS1zIN88US=> M3[1RlQ5KGh? Mn3ISG1UVw>? NHnKTJdp[XNibn:gR4VtdCCleXPs[UBienKnc4SgZZN{\XO|ZXSgZZMh[WOldX31cIF1cW:wIHH0JJN2[i2JMTDwbIF{\Q>? MlTLNlQ1OTd3Nk[=
697 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXTZoRiUUN3ME2xOFgvOzhibl2= NFnuPXBUSU6JRWK=
P12-ICHIKAWA Ml;vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTae4VzUUN3ME25Ok4xPCCwTR?= Mn\iV2FPT0WU
NB69 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIftUXNKSzVyPUG2NU45KG6P NGDBcmJUSU6JRWK=
EoL-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfnTWM2OD1zOEeuNlYhdk1? MVXTRW5ITVJ?
BHT-101 MmG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TEdmlEPTB;MUm4MlI2KG6P NXv0R5NMW0GQR1XS
SK-NEP-1 NIWw[Y1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTJ{MD6wNkBvVQ>? NFP5U2pUSU6JRWK=
MHH-NB-11 MoDuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjoRVJKSzVyPUKyNE4yQSCwTR?= NYrUNFRVW0GQR1XS
AsPC-1 NVv6V45pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofVTWM2OD1{NUKuOVMhdk1? M4\teXNCVkeHUh?=
ES1 NIXzd5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTJ3Nj6yOUBvVQ>? NWTZ[ZNVW0GQR1XS
LAMA-84 NWfDcmlYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzXW2dKSzVyPUK1PE4yQSCwTR?= M33Kc3NCVkeHUh?=
MOLT-16 Mn7HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnZR4FlUUN3ME2yOVgvPDlibl2= MmHvV2FPT0WU
ES7 NHfOZZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzJSI9iUUN3ME2yO|MvODlibl2= M2rvWHNCVkeHUh?=
KY821 MnztS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jmUWlEPTB;M{G0MlEhdk1? MXXTRW5ITVJ?
RT-112 M2XPTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTN{MT6wOUBvVQ>? Mn\EV2FPT0WU
HL-60 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLQSYpOUUN3ME2zOFAvPjZibl2= MWXTRW5ITVJ?
MOLT-4 MnfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTN2NT6xN{BvVQ>? NYKwPIg4W0GQR1XS
KARPAS-45 NWjTe3l1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDybWtHUUN3ME2zO|YvOTZibl2= MYDTRW5ITVJ?
SK-N-AS NIDE[WJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\wSmlEPTB;M{i3Mlg{KG6P MnPwV2FPT0WU
CTB-1 Mn[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTRyNT6wNkBvVQ>? MkS4V2FPT0WU
NKM-1 NW\sNnBFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX2wVnZMUUN3ME20NVEvQDlibl2= Mkj5V2FPT0WU
HTC-C3 NV3pTJlVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3f4XWlEPTB;NEOyMlk2KG6P MXvTRW5ITVJ?
BE-13 Mo\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fjfWlEPTB;NES0MlI4KG6P NGW2dYRUSU6JRWK=
KOSC-2 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV65NXN2UUN3ME20OlYvQSCwTR?= M1HXdXNCVkeHUh?=
NB14 NIXoOlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPhfXRRUUN3ME20PFMvPThibl2= MU\TRW5ITVJ?
CAL-27 M33OdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPxTWM2OD12OUSuOVkhdk1? NYPQTWpVW0GQR1XS
H9 M2e1cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTR7NT60N{BvVQ>? M{D6XXNCVkeHUh?=
RS4-11 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYq0d41CUUN3ME21NFQvPzNibl2= MVTTRW5ITVJ?
PA-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTVyOT64OkBvVQ>? NXrsNmV1W0GQR1XS
MV-4-11 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInpZpRKSzVyPUWxN{45PSCwTR?= MVzTRW5ITVJ?
OS-RC-2 M2rCNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY[2cGo5UUN3ME21NlEvPjJibl2= NXPLWJpVW0GQR1XS
RPMI-8226 MmPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TyWmlEPTB;NUK2Mlg3KG6P NUmzUZJJW0GQR1XS
HGC-27 MlHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHnVIRmUUN3ME21OlQvQTlibl2= NYPhfndVW0GQR1XS
CHP-212 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zhSGlEPTB;NUmzMlU6KG6P MkfZV2FPT0WU
NB10 NWriXHVHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml[wTWM2OD13OUmuNVghdk1? NXi3VYhxW0GQR1XS
HH MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTV7OT60N{BvVQ>? NGPR[|lUSU6JRWK=
EW-16 Mmr0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1:2dGlEPTB;NkCzMlUzKG6P NGTk[5hUSU6JRWK=
ES8 NY[2[45RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXGwbFBoUUN3ME22NFUvOjFibl2= MlHsV2FPT0WU
HAL-01 NYP6dppET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWqzZmk{UUN3ME22NFUvPjdibl2= MlfpV2FPT0WU
A204 MofBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zEV2lEPTB;NkOzMlkyKG6P M33xOXNCVkeHUh?=
MHH-PREB-1 Mof0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PqWmlEPTB;NkO2Mlk6KG6P M{fOenNCVkeHUh?=
EM-2 NVHDc5htT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTZ3MD62OEBvVQ>? MlT3V2FPT0WU
BV-173 NIO0N49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrmPWFKSzVyPU[1Nk41QCCwTR?= NXnqVGdnW0GQR1XS
ONS-76 M1Hu[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTZ5Nz64NkBvVQ>? NV3MU297W0GQR1XS
KM-H2 M3vZ[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTZ7NT61OEBvVQ>? MmXzV2FPT0WU
D-263MG MlvvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\UbFNPUUN3ME23NVcvOTJibl2= NVz3VVhsW0GQR1XS
ES3 NED2PYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFT4bIVKSzVyPUeyPE46OyCwTR?= NGTifXZUSU6JRWK=
VA-ES-BJ NI\HXZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTd|Mj6yO{BvVQ>? NUfyTZllW0GQR1XS
NBsusSR MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vvbmlEPTB;N{SyMlk6KG6P Mlj3V2FPT0WU
NCI-H520 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13nV2lEPTB;N{S2MlUzKG6P NHjtd2NUSU6JRWK=
ES5 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnpN|Y1UUN3ME23OVIvQCCwTR?= MULTRW5ITVJ?
T-24 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\BVWlEPTB;N{e4MlcyKG6P NXLyUYJjW0GQR1XS
SW962 M2TPPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHZ[GhKSzVyPUiwPE43OyCwTR?= MWLTRW5ITVJ?
EW-3 M{KwO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXtZZVKSzVyPUiwPE44PiCwTR?= MVHTRW5ITVJ?
RXF393 NGPXV|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XwNmlEPTB;OEGyMlc6KG6P Mk\hV2FPT0WU
U251 MnPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XPV2lEPTB;OEGzMlg5KG6P NV\mbIVxW0GQR1XS
CAMA-1 NEKyVJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfnSIxKSzVyPUizN{46PCCwTR?= MXzTRW5ITVJ?
JVM-3 MkPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTh3MT63PEBvVQ>? M1Hne3NCVkeHUh?=
COLO-800 M4Hqd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3BW29KSzVyPUi5O{44QCCwTR?= NV23[292W0GQR1XS
OVCAR-5 MlfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDqTWM2OD17MECuNUBvVQ>? M1;h[HNCVkeHUh?=
LB1047-RCC NVnEcYdGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTl{Nz61OkBvVQ>? MkDHV2FPT0WU
SW954 NXvCWVRlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzRTms2UUN3ME25NlkvPDFibl2= MlXKV2FPT0WU
J-RT3-T3-5 NUiyXol3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;1TWM2OD17M{[uNFYhdk1? NWm4bY5uW0GQR1XS
Mewo NFzuS|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDuTWM2OD17M{[uOkBvVQ>? M1jKTXNCVkeHUh?=
NCI-H1770 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;kdmNHUUN3ME25OFAvPTVibl2= NUPHcnozW0GQR1XS
HO-1-N-1 MknGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHlcXpSUUN3ME25OlIvQDFibl2= M2qxZXNCVkeHUh?=
HSC-3 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTE[GtjUUN3ME25OlYvPDhibl2= NYLEeohZW0GQR1XS
TYK-nu MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDMWHUyUUN3ME25PVgvOjVibl2= NV\Tc5JGW0GQR1XS
KYSE-150 M2fHVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfMNIxKSzVyPUGuNFAxPzZizszN NGHOUo9USU6JRWK=
SN12C MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTFwMEC4O|Uh|ryP NY\0eoJOW0GQR1XS
MOLT-13 M1\LWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTFwMEG0NlEh|ryP NULh[W1zW0GQR1XS
TE-11 NELw[nBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTZSpNpUUN3ME2xMlA1QDF{IN88US=> NEDnSVJUSU6JRWK=
DB M{PQPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGSxOo1KSzVyPUGuNFczPzNizszN NE\pUpRUSU6JRWK=
CAL-39 NFPrXFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF:5c41KSzVyPUGuNFc2OjJizszN MVjTRW5ITVJ?
A3-KAW Ml6yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\FTWM2OD1zLkC4OFA5KM7:TR?= M2jIWnNCVkeHUh?=
CHP-134 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTFwMUG4NFch|ryP MlrqV2FPT0WU
TGW MnjXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fqTGlEPTB;MT6xNlM6PSEQvF2= MU\TRW5ITVJ?
QIMR-WIL MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmq4TWM2OD1zLkGzNVM1KM7:TR?= NV\QUW9rW0GQR1XS
NCI-SNU-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGm0OnZKSzVyPUGuNVY{PTRizszN MXfTRW5ITVJ?
CGTH-W-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\ETWM2OD1zLkG3NVg3KM7:TR?= MWDTRW5ITVJ?
MHH-ES-1 NInOV3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrwSnlKSzVyPUGuNVc6QDZizszN MYXTRW5ITVJ?
LB2241-RCC M4PWOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTFwMUi2NkDPxE1? M1\tUnNCVkeHUh?=
ML-2 MnrNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjjeHh2UUN3ME2xMlIxPzN2IN88US=> MnfjV2FPT0WU
COR-L23 MmfWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\xeWlEPTB;MT6yNlk{OyEQvF2= MWfTRW5ITVJ?
BFTC-905 M3HDfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\ZO2hEUUN3ME2xMlI1OjZ5IN88US=> NHz1TZFUSU6JRWK=
Hs-578-T MofkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHkVZE2UUN3ME2xMlI2QDF5IN88US=> NVX0ZmMxW0GQR1XS
KG-1 NFX4WZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfBOY1KSzVyPUGuNlY3QDZizszN MmixV2FPT0WU
HEL MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrNdnNKSzVyPUGuNlk{OzhizszN M1riO3NCVkeHUh?=
A549 M3njV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzCTWM2OD1zLkK5N|k6KM7:TR?= Mo\rV2FPT0WU
COLO-741 M2q5SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjRfXRoUUN3ME2xMlMzODh7IN88US=> MX3TRW5ITVJ?
PC-3 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTFwM{WyNlEh|ryP M3vIdHNCVkeHUh?=
HOS MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3W2[GlEPTB;MT6zOVI6PiEQvF2= MoDrV2FPT0WU
HT-1080 NWKzUXpRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\xfppKSzVyPUGuN|c2OTlizszN M1XOXHNCVkeHUh?=
TE-8 M17C[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\o[3RNUUN3ME2xMlQyPzd2IN88US=> NW\FPHJ4W0GQR1XS
BHY MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTFwNE[5NlMh|ryP NHzl[ZJUSU6JRWK=
BB65-RCC Moi3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrTSZhKSzVyPUGuOVA2OjhizszN MVLTRW5ITVJ?
HN M3fvUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1G1[2lEPTB;MT61OFA4OSEQvF2= NWqwVHlnW0GQR1XS
NCI-H441 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\DTmlEPTB;MT61OFkxPyEQvF2= NIKwWJZUSU6JRWK=
RPMI-8866 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mle0TWM2OD1zLkW4OVA4KM7:TR?= M2nYenNCVkeHUh?=
CAL-62 NWL4b4RzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fHU2lEPTB;MT62NFg3OiEQvF2= NHv6UpBUSU6JRWK=
MG-63 NHTnUlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{X1b2lEPTB;MT62NVgyOyEQvF2= MnuwV2FPT0WU
SK-LU-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrpdVhjUUN3ME2xMlYzOTV{IN88US=> NELtZoZUSU6JRWK=
BCPAP MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLmdFRlUUN3ME2xMlY3PDV5IN88US=> MWDTRW5ITVJ?
22RV1 NY\nVHRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTFwNke4OFMh|ryP MX;TRW5ITVJ?
T47D NXnhNI5bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTFwNkiwOlEh|ryP M4HaNXNCVkeHUh?=
MSTO-211H MmXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfQRZNKSzVyPUGuOlk3ODNizszN MnvUV2FPT0WU
DEL Ml;kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TrV2lEPTB;MT63NFI4OyEQvF2= NEHhclZUSU6JRWK=
H4 NI\vWW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnxTWM2OD1zLkezNlEzKM7:TR?= M2joZXNCVkeHUh?=
CAL-51 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjzTWM2OD1zLke0PFU2KM7:TR?= NUHPPJUxW0GQR1XS
ABC-1 NF:3c|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LPcWlEPTB;MT63PFU5OiEQvF2= M3H4OXNCVkeHUh?=
MZ2-MEL M3rFXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\XT2kzUUN3ME2xMlc6PTR{IN88US=> M{\XNXNCVkeHUh?=
YKG-1 Mm[3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDQTWM2OD1zLkixNFYyKM7:TR?= MXnTRW5ITVJ?
KM12 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDYfIFOUUN3ME2xMlgyPjB{IN88US=> M{TIeXNCVkeHUh?=
L-363 NFTIXGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fVeGlEPTB;MT64O|QyOiEQvF2= M4nyRnNCVkeHUh?=
KU812 NG\yOJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HkSWlEPTB;MT64PVI5OiEQvF2= M3u0eHNCVkeHUh?=
LOXIMVI NHXUZnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmezTWM2OD1zLkmxNlI5KM7:TR?= MlzmV2FPT0WU
G-401 NUHiPYhZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTFwOUK0Nlgh|ryP NI\aRndUSU6JRWK=
SW780 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPDUZFkUUN3ME2xMlk3OjR4IN88US=> NGPu[XhUSU6JRWK=
SW872 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzWTWM2OD1zLkm4N|Mh|ryP M37MT3NCVkeHUh?=
NB7 M3GyV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3H3e2lEPTB;MT65PVMzOyEQvF2= MmTiV2FPT0WU
T98G MnnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVT2VFB{UUN3ME2yMlAxPjZ4IN88US=> MlXVV2FPT0WU
SW1710 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjGeFhKSzVyPUKuNFY6PDVizszN MVnTRW5ITVJ?
NCI-H1573 M3y1OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHPSpRKSzVyPUKuNFczQThizszN NH\qfIlUSU6JRWK=
KE-37 M3noSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjaUZpKSzVyPUKuNFg6PTFizszN Ml7vV2FPT0WU
786-0 M4LVZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTJwMUW0N|kh|ryP MojMV2FPT0WU
SAS M3rTZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTJwMkCzO|Qh|ryP M{joZ3NCVkeHUh?=
CAL-54 M{PPVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWH0bGVKUUN3ME2yMlIxPDF|IN88US=> NXezd5BKW0GQR1XS
SF268 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nsVmlEPTB;Mj6yN|EzOiEQvF2= M1nVWXNCVkeHUh?=
SW620 MnHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnj3TWM2OD1{LkK2NVY6KM7:TR?= M17PW3NCVkeHUh?=
MN-60 Mn\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLnfYtKSzVyPUKuN|ExPiEQvF2= NGLrPYtUSU6JRWK=
EFO-27 NFzTVZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7nSXlKSzVyPUKuN|IxPThizszN MXfTRW5ITVJ?
NCI-H747 MoLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTJwM{KxPVkh|ryP MUjTRW5ITVJ?
HCC2218 NV7Fb5duT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWqxPVNCUUN3ME2yMlM2Ozd2IN88US=> MnnQV2FPT0WU
MIA-PaCa-2 NULMTmExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTJwM{[0N|ch|ryP NV:2R4RCW0GQR1XS
SJSA-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTJwM{e3PVYh|ryP MWHTRW5ITVJ?
RKO MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLmTWM2OD1{LkO4OFk3KM7:TR?= NGrFUGdUSU6JRWK=
NB6 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkG1TWM2OD1{LkSwN|c1KM7:TR?= NV;wUYI1W0GQR1XS
ES4 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPlTWM2OD1{LkS1OFIzKM7:TR?= NFfTZYNUSU6JRWK=
EGI-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fjbmlEPTB;Mj60Olg5OyEQvF2= NVTPZWVqW0GQR1XS
CTV-1 MorLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPXUlVKSzVyPUKuOVI4PzNizszN NUnBPVNHW0GQR1XS
NCI-H1355 NXTzUVNwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXRemszUUN3ME2yMlU2QTVzIN88US=> NX;pRVJkW0GQR1XS
GT3TKB MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1X3N2lEPTB;Mj61PVE6QSEQvF2= MmfSV2FPT0WU
SK-HEP-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1KwfGlEPTB;Mj61PVI3PiEQvF2= M4rESXNCVkeHUh?=
GAMG M3XH[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7YU2JKSzVyPUKuOVk{QTRizszN M4nVWnNCVkeHUh?=
SK-MES-1 Mnu3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTJwNkG4NFMh|ryP MWrTRW5ITVJ?
RO82-W-1 M1jufmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrwTWM2OD1{Lk[yNFU4KM7:TR?= MoryV2FPT0WU
ECC10 M2nOSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkK5TWM2OD1{LkewNlA3KM7:TR?= MUDTRW5ITVJ?
MCF7 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXG2VW5pUUN3ME2yMlcyPDZ2IN88US=> MoHjV2FPT0WU
D-283MED NWPG[HhpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XaZ2lEPTB;Mj63NlQ{KM7:TR?= M3SyNnNCVkeHUh?=
RPMI-7951 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTJwN{W2PVQh|ryP M17meXNCVkeHUh?=
Ramos-2G6-4C10 NF7tS29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\qcmVKSzVyPUKuO|cxQTlizszN NFGxfVNUSU6JRWK=
KGN MmDsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojHTWM2OD1{LkixPFg1KM7:TR?= NH[yZ3dUSU6JRWK=
NUGC-3 M16yTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPPTWM2OD1{LkiyOVA2KM7:TR?= MX;TRW5ITVJ?
NCI-H292 NHmy[JBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTtWWg6UUN3ME2yMlg2ODV|IN88US=> NYX5NoZZW0GQR1XS
Becker MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHYTWM2OD1{Lkm1PFMzKM7:TR?= NHXLb4ZUSU6JRWK=
NCI-H1299 M1zKOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXCd2FKSzVyPUOuNFUzPjNizszN MVnTRW5ITVJ?
ETK-1 M{fkb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGT2UVRKSzVyPUOuNFU1OyEQvF2= NWLhemdkW0GQR1XS
TK10 M1XvTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHSTWM2OD1|LkKwNVY2KM7:TR?= NYTO[VhEW0GQR1XS
VMRC-RCZ MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTNwM{[0PFgh|ryP MV3TRW5ITVJ?
YH-13 M1jW[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rVO2lEPTB;Mz60OFA4QSEQvF2= NVnLV2dlW0GQR1XS
DU-145 NYPOTWx1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmP2TWM2OD1|LkS2NlY6KM7:TR?= NGLZSZFUSU6JRWK=
SW1088 MmHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3GyUmlEPTB;Mz60O|Q4KM7:TR?= NGLEfGVUSU6JRWK=
HOP-92 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1O3eGlEPTB;Mz61NFM1OiEQvF2= NFG2eYFUSU6JRWK=
KP-N-YS M33kdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXxPHFGUUN3ME2zMlYzOTN7IN88US=> NGrzdmRUSU6JRWK=
NCI-H460 M3PQdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjVclBHUUN3ME2zMlY3PzNizszN M2[1[3NCVkeHUh?=
U-2-OS NV3BepYyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1j4eWlEPTB;Mz63NlU{PSEQvF2= NIjLR4RUSU6JRWK=
A101D Ml[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnOW5gyUUN3ME2zMlc3QTN4IN88US=> MlX2V2FPT0WU
MDA-MB-231 M{OzZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTNwOEG5OVEh|ryP MXfTRW5ITVJ?
IST-MES1 NH\2dnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHUc4RyUUN3ME2zMlg{OiEQvF2= M1LOWHNCVkeHUh?=
COR-L105 NE\HPVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfUPGJKSzVyPUSuNFE5KM7:TR?= NH65dnpUSU6JRWK=
NCI-H1437 MlzrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DTXmlEPTB;ND6wNlMxOiEQvF2= MlO1V2FPT0WU
CAL-85-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnVNmR5UUN3ME20MlAzPDZzIN88US=> NGjIb2JUSU6JRWK=
MZ1-PC MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTRwMUi1OVYh|ryP M1TZenNCVkeHUh?=
VM-CUB-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPhVlV4UUN3ME20MlMyOjh2IN88US=> Moj0V2FPT0WU
CHL-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXHOFk6UUN3ME20MlMzOTZ7IN88US=> NFn2UVFUSU6JRWK=
MDA-MB-361 NEfFbFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTRwM{OxOVMh|ryP NW\B[po1W0GQR1XS
NCI-H661 Mom5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzMdWdKSzVyPUSuOVAxQTJizszN NGXOeXNUSU6JRWK=
EW-11 NF7uPY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rxXGlEPTB;ND61NlI{OSEQvF2= NIDtXo9USU6JRWK=
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HLE NXfSSYg2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPXcoVNUUN3ME2xOE4{QDV{IN88US=> MXPTRW5ITVJ?
SW1573 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mke3TWM2OD1zND60OFM2KM7:TR?= MUfTRW5ITVJ?
KYSE-140 NGjXSZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LuWWlEPTB;MUSuOlMzPyEQvF2= NFfxUYVUSU6JRWK=
SK-PN-DW MnnlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTF2LkiwNFEh|ryP MV7TRW5ITVJ?
A253 NUnxWGVHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnmdlRwUUN3ME2xOU4xPjJ3IN88US=> NV3ZbFVyW0GQR1XS
CAL-12T M2\xPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHLTWM2OD1zNT60OlYzKM7:TR?= NUXmXG1CW0GQR1XS
COLO-679 NIDyemtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnrcFlKSzVyPUG1Mlc3QDNizszN MYLTRW5ITVJ?
UACC-257 NW\qSIRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHoeJBKSzVyPUG2MlEzODFizszN MV3TRW5ITVJ?
U-87-MG MlvKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\lfZozUUN3ME2xOk4{PTJ|IN88US=> MYXTRW5ITVJ?
HCC1806 Mn\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTF4LkewO|Eh|ryP MXPTRW5ITVJ?
NCI-H2170 MlPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTF5LkK0OFgh|ryP M1y3[nNCVkeHUh?=
AGS NGD3dIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrUWpRKSzVyPUG3MlM5ODhizszN NGP1d3hUSU6JRWK=
MEL-HO M2Pr[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nKXmlEPTB;MUeuO|UxOyEQvF2= MYXTRW5ITVJ?
SW48 MmTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTF5Lke3NVYh|ryP MV7TRW5ITVJ?
HuP-T4 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHRTI9KSzVyPUG4MlAzODZizszN NXHtbY9tW0GQR1XS
NCI-H720 MmrNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\lfnIyUUN3ME2xPE4yPDB{IN88US=> MnnGV2FPT0WU
RCC10RGB NWHnPVV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDvTWM2OD1zOD6xOlk4KM7:TR?= Mn7qV2FPT0WU
HD-MY-Z MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PxSWlEPTB;MUiuNlI2PCEQvF2= MVTTRW5ITVJ?
A427 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXL2d2o2UUN3ME2xPE42ODl2IN88US=> NEi3NYVUSU6JRWK=
HCC2998 NFX2O|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTF6Lk[wOVEh|ryP MorLV2FPT0WU
EPLC-272H MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1:w[2lEPTB;MUmuNFQ{PCEQvF2= M1n2[3NCVkeHUh?=
C32 M{LxOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrKblBKSzVyPUG5MlA1PSEQvF2= NUPFdFZzW0GQR1XS
UMC-11 MlfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTF7LkKxNlMh|ryP NGDSUZlUSU6JRWK=
CaR-1 NUDjNlhjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17kV2lEPTB;MUmuOlgxPCEQvF2= MlPaV2FPT0WU
KYSE-410 M3The2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{[4dmlEPTB;MUmuPVE{QSEQvF2= MnL3V2FPT0WU
HuCCT1 M4LBTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTJyLk[yPVQh|ryP MX;TRW5ITVJ?
LB996-RCC MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DNemlEPTB;MkCuO|E3QCEQvF2= M17GWnNCVkeHUh?=
KYSE-70 MoDsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEexdmxKSzVyPUKwMlgxPTlizszN NEfjd45USU6JRWK=
CAL-72 NGryOFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHWOodKSzVyPUKwMlkyPSEQvF2= NWTodW57W0GQR1XS
Capan-2 NUH0UppJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoOxTWM2OD1{MT6wOFE{KM7:TR?= MX;TRW5ITVJ?
PANC-08-13 MmW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEG2d2dKSzVyPUKxMlI2OTVizszN M3nWTHNCVkeHUh?=
SBC-1 M3SxRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTJzLkOwPFEh|ryP MljYV2FPT0WU
MFM-223 NW\3O|BtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTJzLkOzOFIh|ryP NIn2NYVUSU6JRWK=
BB49-HNC MmLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWeyXG1PUUN3ME2yNU42PzF4IN88US=> MWTTRW5ITVJ?
SH-4 NHPvW2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPtVGdGUUN3ME2yNU43PjF6IN88US=> NUjUOWN3W0GQR1XS
HuO9 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXMb|JIUUN3ME2yNU46QDJ3IN88US=> MWPTRW5ITVJ?
AM-38 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XyRmlEPTB;MkKuNFQ5PSEQvF2= NUPXeXVRW0GQR1XS
A431 NFjac3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTJ|LkKxNVkh|ryP MWTTRW5ITVJ?
YAPC M175Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1S2PWlEPTB;MkOuNlY2OSEQvF2= M2DaOXNCVkeHUh?=
LU-139 NVPCdnJyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;VSJJwUUN3ME2yN{41QDB7IN88US=> NIfiS4FUSU6JRWK=
HEC-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvNSZRYUUN3ME2yN{41QTN5IN88US=> M37CTXNCVkeHUh?=
SCC-25 NWDMSWFUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XifWlEPTB;MkSuN|AxPiEQvF2= MmL4V2FPT0WU
HT-29 NYr6eIJqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFW5S45KSzVyPUK0MlM5OjNizszN Mln0V2FPT0WU
PC-14 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\aXWlKSzVyPUK0MlY2PzFizszN M37pb3NCVkeHUh?=
Calu-6 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrJWlRNUUN3ME2yOU42ODdzIN88US=> MVTTRW5ITVJ?
SJRH30 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHEUWNKSzVyPUK1MlY1QTZizszN M2rxbnNCVkeHUh?=
ChaGo-K-1 M4jIPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTJ4LkG2Nlkh|ryP NWLrT3R[W0GQR1XS
IA-LM NGHzb2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TkVGlEPTB;Mk[uN|Y1PSEQvF2= MonmV2FPT0WU
GP5d MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHicIRKSzVyPUK2MlQ1QTFizszN M4HyXHNCVkeHUh?=
NCI-H2291 NWr1SJY1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33vfGlEPTB;Mk[uOlU1OSEQvF2= NGnPc2NUSU6JRWK=
BALL-1 NX\o[W13T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLKNVRHUUN3ME2yOk46Ozl5IN88US=> MUjTRW5ITVJ?
HCC1954 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVL0[XltUUN3ME2yOk46QDB6IN88US=> MX\TRW5ITVJ?
NCI-H2452 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3OTWM2OD1{Nz60NVY{KM7:TR?= NIjsb|hUSU6JRWK=
LU-99A NUm1[IZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTJ5LkW1PFIh|ryP NELVbpRUSU6JRWK=
NTERA-S-cl-D1 NYnZcWNHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;JTWM2OD1{Nz63Nlk6KM7:TR?= M1jVd3NCVkeHUh?=
PANC-10-05 NED2[o9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\OTWM2OD1{Nz63O|c2KM7:TR?= M1\4dHNCVkeHUh?=
NCI-H2405 Mn\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHX1dJpKSzVyPUK3Mlk{QDdizszN M{C1dXNCVkeHUh?=
MDA-MB-415 Ml3NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fkPWlEPTB;MkiuOFE{PyEQvF2= M1XKWnNCVkeHUh?=
NCI-H2342 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTGTWM2OD1{OD61NlgyKM7:TR?= M4rkU3NCVkeHUh?=
TGBC24TKB NEHYclFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXxUVJKSzVyPUK4MlcyOTdizszN MUTTRW5ITVJ?
LU-134-A NUfzeGZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUThfVdvUUN3ME2yPE46OjZzIN88US=> NWqyVnRzW0GQR1XS
SCC-4 NWWxeog5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTNzLkC0PVQh|ryP M2rGRXNCVkeHUh?=
Saos-2 NH;VPZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTNzLkmzNFYh|ryP M1\GT3NCVkeHUh?=
RERF-LC-MS NGHNRlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrkWmE6UUN3ME2zNk45OjNzIN88US=> M{LQN3NCVkeHUh?=
M14 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zRWmlEPTB;M{KuPVc3PCEQvF2= M3TLXnNCVkeHUh?=
HPAF-II MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3KbHRKSzVyPUOzMlUxOTFizszN NILRVXZUSU6JRWK=
NCI-H1755 MoruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDiTWM2OD1|ND6zN|A2KM7:TR?= MYTTRW5ITVJ?
D-392MG NYrrfmVST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTN3Lki2O|Qh|ryP NF72bIxUSU6JRWK=
A704 M1z2O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLOZ3RKSzVyPUO2MlA1OjdizszN MmnUV2FPT0WU
CP50-MEL-B MnjpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nxcGlEPTB;M{[uNVkyOSEQvF2= NWDSeYtRW0GQR1XS
EW-18 NIjjblBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1y2bGlEPTB;M{[uOFUzKM7:TR?= NVPFTJJVW0GQR1XS
WM-115 NYTKSFVST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDDfHRwUUN3ME2zOk45ODl7IN88US=> MVPTRW5ITVJ?
LU-65 NF;jbG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;VcWdKSzVyPUO3MlE1OTdizszN NETldo5USU6JRWK=
NCI-H1563 MmjYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTN5LkK0PFQh|ryP NHiye4hUSU6JRWK=
DBTRG-05MG MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTN6LkC2PVEh|ryP NYrGOXdKW0GQR1XS
NCI-H630 M{fWXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml:4TWM2OD1|OD60O|E1KM7:TR?= NYHoWGR4W0GQR1XS
NCI-H1155 MmD5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfZfGlKSzVyPUO5MlI1OiEQvF2= MVfTRW5ITVJ?
OVACR-3 NX\ZdWhIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnkWVU2UUN3ME2zPU46OTl3IN88US=> NUHEbmxFW0GQR1XS
OAW-42 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnQZplTUUN3ME20NE41OjV6IN88US=> M3zqWHNCVkeHUh?=
JVM-2 NWniSVdkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUK5[JlkUUN3ME20NU4zPDF3IN88US=> Mnn2V2FPT0WU
C3A NHm5e4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTRzLkO0OFch|ryP M4fxTXNCVkeHUh?=
HT55 M1zDbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jrO2lEPTB;NEKuNlg1OSEQvF2= NED6UINUSU6JRWK=
OVCAR-4 NV3zVnRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYSwTVRDUUN3ME20Nk4zQTd2IN88US=> M1\JVHNCVkeHUh?=
MEG-01 NHHJN3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTR{LkS2NVYh|ryP NVj3XXJmW0GQR1XS
NCI-H82 Mo\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPWbXBKSzVyPUSzMlk5QTJizszN M2\LW3NCVkeHUh?=
JEG-3 NHz4UWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTR2Lkm0O{DPxE1? NHOzfIZUSU6JRWK=
BPH-1 NE\yV5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1W3TmlEPTB;NE[uN|k6QCEQvF2= MoDOV2FPT0WU
MPP-89 M2W5dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{G2R2lEPTB;NEeuNlg6QCEQvF2= NVT3[4l4W0GQR1XS
ALL-PO NFXWV2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvwUJBKSzVyPUS3MlQyQDhizszN MUDTRW5ITVJ?
HT NFnIVWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTR5LkS5NkDPxE1? M2rCZ3NCVkeHUh?=
NCI-H2347 MoDXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfETWM2OD12OD6wO|E2KM7:TR?= NHT1UoJUSU6JRWK=
A2780 NILRXZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIO3cmVKSzVyPUS5MlQzOjhizszN NFLJRnZUSU6JRWK=
KARPAS-299 MoXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXub4dKSzVyPUS5MlUyOTlizszN MlnuV2FPT0WU
NCI-H1651 Mk\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEm1SJlKSzVyPUS5Mlg5OjFizszN M1\t[3NCVkeHUh?=

... Click to View More Cell Line Experimental Data

体内研究 150 mg/kg PD 0332991处理 MDA-MB-435移植瘤完全抑制肿瘤。在多种人类肿瘤移植瘤中,PD 0332991也显示广谱抗癌活性,通过除去血管中p-Rb和增殖Marker Ki-67,且调节基因使其处于E2F转录水平控制。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

+ 展开

Cdk实验:

PD0332991溶解在DMSO中。在96孔板上进行CDK 实验。通过杆状病毒感染,所有的CDK-cyclin 激酶复合体 在昆虫细胞中表达。实验底物为与GST融合的一段pRb。每孔体积为0.1 ml,包含:终浓度为20 mm Tris-HCl(pH 为7.4), 50 mmNaCl, 1 mm二硫苏糖醇, 10 mmMgCl2, 25 μm ATP (用于CDK4-cyclin D1, CDK6-cyclin D2,和CDK6-cyclin D3)或12 μm ATP (用于CDK2-cyclin E, CDK2-cyclin A, 和CDC2-cyclin B),0.25 μCi [γ-32P]ATP, 20 ng 酶, 1 μg GST·RB-Cterm, 及PD 0332991 (0.001-0.1μM)。除了[γ-32P]ATP的所有混合物加到孔中,放在搅拌器上搅拌2分钟。加入 [γ-32P]ATP开始反应, 在25 oC下温育15分钟。加入0.1 ml 20% 三氯乙酸终止反应, 在4 oC维持至少1小时,使底物沉淀。用0.2 ml 10%三氯乙酸冲洗5次,用β-计数器板测定掺入的放射性。
细胞实验:

[1]

+ 展开
  • Cell lines: MDA-MB-435, ZR-75-1, T-47D, MCF-7, H1299, Colo-205, MDA-MB-468, H2009, CRRF-CEM,和K562细胞
  • Concentrations: 0.01-1 μM
  • Incubation Time: 24小时
  • Method:

    肿瘤细胞包括MDA-MB-435, ZR-75-1, T-47D, MCF-7, H1299, Colo-205, MDA-MB-468, H2009, CRRF-CEM,及K562按每孔2×104个细胞接种在96孔板上,温育过夜。加入PD 0332991 (0.01-1 μM) ,37oC温育24小时。每孔加入[14C]胸甘(0.1 μCi) ,进行同位素示踪,持续72小时。用β-计数器板测定掺入的放射性。


    (Only for Reference)
动物实验:

[1]

+ 展开
  • Animal Models: 携带晚期人类肿瘤移植瘤,包括结肠-205, MDA-MB-435 乳腺癌, SF-295 恶性胶质瘤, ZR-75-1 乳腺癌, PC-3 前列腺癌, H125 肺癌, SW-620结肠癌, H23肺癌,及MDA-MB-468 乳腺癌 (Rb 阴性)的SCID鼠
  • Formulation: 溶解在乳酸钠buffer(50 mM, pH 4.0)中
  • Dosages: 0-150 mg/kg
  • Administration: 口服饲喂
    (Only for Reference)

溶解度 (25°C)

体外 Water 30 mg/mL (61.98 mM)
DMSO 3 mg/mL warmed (6.19 mM)
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
Saline
6 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 483.99
化学式

C24H29N7O2.HCl

CAS号 827022-32-2
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03472573 Recruiting Recurrent B Acute Lymphoblastic Leukemia|Refractory B Acute Lymphoblastic Leukemia Sidney Kimmel Cancer Center at Thomas Jefferson University|Pfizer|Thomas Jefferson University May 9 2018 Phase 1
NCT03423199 Recruiting Breast Neoplasms National Cancer Center Japan|Pfizer|Korean Cancer Study Group February 9 2018 Phase 3
NCT03147287 Recruiting Metastatic Breast Cancer Dana-Farber Cancer Institute|Pfizer August 9 2017 Phase 2
NCT02905318 Recruiting Prostate Cancer Canadian Cancer Trials Group|Pfizer February 9 2017 Phase 2
NCT03535506 Recruiting DCIS Georgetown University|Pfizer October 8 2018 Phase 2
NCT03609047 Not yet recruiting Breast Cancer Stage II|Breast Cancer Stage III European Organisation for Research and Treatment of Cancer - EORTC|Pfizer January 7 2019 Phase 2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID