Palbociclib (PD-0332991) HCl

Pfizer辉瑞授权 目录号:S1116

Palbociclib (PD-0332991) HCl Chemical Structure

Molecular Weight(MW): 483.99

Palbociclib (PD-0332991) HCl是一种高度选择性的CDK4/6抑制剂,无细胞试验中IC50分别为11 nM/16 nM。它对CDK1/2/5,EGFR,FGFR,PDGFR,InsR等没有抑制活性。Phase 3。

规格 价格 库存 购买数量  
RMB 902.49 现货
RMB 1406.17 现货
RMB 4670.26 现货
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产品安全说明书

CDK抑制剂选择性比较

生物活性

产品描述 Palbociclib (PD-0332991) HCl是一种高度选择性的CDK4/6抑制剂,无细胞试验中IC50分别为11 nM/16 nM。它对CDK1/2/5,EGFR,FGFR,PDGFR,InsR等没有抑制活性。Phase 3。
特性 PD-0332991作为有应用前景的工具测定CDK激酶是否具有明显的治疗价值。
靶点
CDK4/CyclinD3 [1]
(Cell-free assay)
CDK4/CyclinD1 [1]
(Cell-free assay)
CDK6/CyclinD2 [1]
(Cell-free assay)
9 nM 11 nM 15 nM
体外研究

PD 0332991 对其他蛋白激酶包括EGFR, FGFR, PGFR, IR等没有抑制效果。 PD 0332991作用于Cdk4时是非ATP竞争性抑制剂。PD 0332991抑制MDA-MB-435乳腺癌细胞,IC50为66 nM,是由于Rb 在Ser780的磷酸化作用下降。PD 0332991抑制胸苷合并到Rb阳性的人类乳腺癌,结肠癌 肺癌,及白血病的DNA中,IC50值为4 nM到0.17 μM。PD 0332991作用于Rb阴性细胞没有抑制效果。PD 0332991作用于MDA-MB-453乳腺癌细胞和结肠-205细胞使细胞积累在G1期。[1]PD 0332991也有效作用于骨髓瘤5T33MM细胞,使细胞对Bortezomib敏感。[2]PD 0332991抑制luminalER-阳性和HER2-增强的乳腺癌细胞系,包括MDA-MB-175 ZR-75-30 CAMA-1 MDA-MB-134 HCC-202 UACC-893 等等。在这些细胞系中,PD 0332991增强Tamoxifen和Trastuzumab 的活性。在MCF7抗Tamoxifen细胞中,PD 0332991也增强tamoxifen 的敏感性。[3] 最新研究显示PD 0332991可以抑制恶性横纹肌样肿瘤(MRT)细胞系包括MP-MRT-AN, KP-MRT-RY, G401, KP-MRT-NS,且MRT细胞系对PD 0332991敏感性和p16表达呈负相关。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MOLM13 NUjKeXNoU2mwYYPlJGF{e2G7 NEfsTIQzPCCq M3PlPWlvcGmkaYTpc44hd2ZiQ1TLOEBie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJHJjKHCqb4PwbI9zgWyjdHnvckB4cXSqIFnDOVAhd2ZiMD6wNFIh|ryP NX3DWod2OjR4NEGxNFM>
COLO205 NWTD[ZpHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLF[ZQ4OiCq MXzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5Nme3OnZDDhd{BqdmOxcoDvdoF1cW:wIH;mJHs{UF22aIntbYRqdmViaX70c{BFVkFid3n0bEBKSzVyIH;mJFAvODN4IN88US=> MVmyOFY1OTFyMx?=
U937 NEfF[45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkG5O|IhcA>? M4TkS2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2W|c3XkJIF{KGmwY3;ydI9z[XSrb36gc4YhYzOKXYTofY1q\GmwZTDpcpRwKESQQTD3bZRpKEmFNUCgc4YhOC5zNDFOwG0> NIrudnAzPDZ2MUGwNy=>
MOLM13 MkjVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkL2O|IhcA>? NXm2T5FmSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNU2xOOTNiY3XscJMhcGG{Yn;ybY5oKE[OVEOgTXRFKG23dHHueEBie3Onc4Pl[EBieyCrbnPvdpBwemG2aX;uJI9nKFt|SG30bJlucWSrbnWgbY51dyCGTlGge4l1cCCLQ{WwJI9nKDBwMEm2JO69VQ>? M{\OdlI1PjRzMUCz
MOLM13 NETs[mdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXS3NkBp MU\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IIPvdoFn\W6rYj3y[ZNqe3SjboSgbJVu[W5iTV;MUVE{KGOnbHzzJIF{e2W|c3XkJIF{KGmwY3;ydI9z[XSrb36gc4YhYzOKXYTofY1q\GmwZTDpcpRwKESQQTD3bZRpKEmFNUCgc4YhOC5yOU[g{txO NUPjZmpZOjR4NEGxNFM>
MDA-MB-435 Mnr3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HzS|I1KGh? Mn;HTWM2OD1yLkG2JO69VQ>? M3LxblE2QDBzOEOx
K562 NHvCNVBEgXSxdH;4bYMhSXO|YYm= M3TTPFk3KGh? MX;EUXNQ NHvIWoVKSzVyPUKg{txO NUCxbXF5OjR2MUe1OlY>
DU145 MorWR5l1d3SxeHnjJGF{e2G7 NVTlUXg2QTZiaB?= MknMSG1UVw>? NEPRe5RKSzVyPUeuOUDPxE1? MXeyOFQyPzV4Nh?=
MDA-MB-231 M4TXO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYqxJO69VQ>? NI\RUGUzPCCq M2DC[WROW09? NEK4RVlE\WyuIHP5Z4xmKGG{cnXzeEBie3Onc4Pl[EBieyCjY3P1cZVt[XSrb36gZZQhTzFicHjhd4U> MWqyOFQyPzV4Nh?=
MCF7 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW[xJO69VQ>? M2jiXVI1KGh? MmfNSG1UVw>? NUTFNopZS2WubDDjfYNt\SCjcoLld5Qh[XO|ZYPz[YQh[XNiYXPjeY12dGG2aX;uJIF1KEdzIIDoZZNm NVXFUVl1OjR2MUe1OlY>
MCF7 MUXLbY5ie2ViQYPzZZk> M3PwWVUh|ryP MYOyOEBp MkXiSG1UVw>? NV7VfYM2UW6qaXLpeIlwdiCxZjDy[YNwdWKrbnHueEBETEt2L3P5Z4xqdkRzIHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZicnX0bY5w[myjc4TvcYEheGixc4Doc5J6dGG2aX;uJIF1KFOncke4NC=> MYKyOFQyPzV4Nh?=
MDA-MB-231 MlTsT4lv[XOnIFHzd4F6 MVG1JO69VQ>? NYXZc|I2OjRiaB?= NWXmb4JmTE2VTx?= MYXJcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IFPET|Qw[3mlbHnuSFEh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBz\XSrbn;icIF{fG:vYTDwbI9{eGixconsZZRqd25iYYSgV4VzPzhy M2i1d|I1PDF5NU[2
MDA-MB-231 MUPGeY5kfGmxbjDBd5NigQ>? NFzKPWUyNTFyIN88US=> NInYZpUzPCCq MYLEUXNQ NH3WV2lld2W|IH7veEBqdmS3Y3WgZZBweHSxc3nzJIF{e2W|c3XkJIF{KFCDUmCgZ4xm[X[jZ3W= NUHSd|FvOjR2MUe1OlY>
MCF7 MmHVSpVv[3Srb36gRZN{[Xl? M3L6fFEuOTBizszN Mn:wNlQhcA>? MnTuSG1UVw>? MmjX[I9meyCwb4SgbY5lfWOnIHHwc5B1d3OrczDhd5Nme3OnZDDhd{BRSVKSIHPs[YF3[Wen NGjn[3YzPDRzN{W2Oi=>
MDA-MB-231 Ml64SpVv[3Srb36gRZN{[Xl? MWOwMlUuOSEQvF2= MYm0PEBp Ml3vSG1UVw>? NWHyR5JucGG|IH7vJGNmdGxiY4njcIUh[XK{ZYP0JIF{e2W|c3XkJIF{KGGlY4XteYxifGmxbjDheEB{fWJvR{GgdIhie2V? M3PFUVI1PDF5NU[2
MCF7 NGr0N|FHfW6ldHnvckBCe3OjeR?= M2fGNVAvPS1zIN88US=> NGXCcGM1QCCq Mn;hSG1UVw>? MUfoZZMhdm9iQ3XscEBkgWOuZTDhdpJme3RiYYPz[ZN{\WRiYYOgZYNkfW23bHH0bY9vKGG2IIP1Zk1IOSCyaHHz[S=> NGPQUlEzPDRzN{W2Oi=>
697 NIG5SnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfpNmJmUUN3ME2xOFgvOzhibl2= Ml7NV2FPT0WU
P12-ICHIKAWA NYSxUJQ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vqXGlEPTB;OU[uNFQhdk1? MYHTRW5ITVJ?
NB69 M{P2OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTF4MT64JI5O M2jvcXNCVkeHUh?=
EoL-1 NHjrO2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTF6Nz6yOkBvVQ>? NH3aVVBUSU6JRWK=
BHT-101 NEXPPI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTF7OD6yOUBvVQ>? NYPCd5F{W0GQR1XS
SK-NEP-1 Mo\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTOW2xKSzVyPUKyNE4xOiCwTR?= NIjHeXhUSU6JRWK=
MHH-NB-11 M33Ccmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjrUnU2UUN3ME2yNlAvOTlibl2= M2fMdXNCVkeHUh?=
AsPC-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TpRWlEPTB;MkWyMlU{KG6P M4fPd3NCVkeHUh?=
ES1 MlXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXQZnZKSzVyPUK1Ok4zPSCwTR?= NV3xWXM6W0GQR1XS
LAMA-84 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTJ3OD6xPUBvVQ>? Mn7vV2FPT0WU
MOLT-16 NXLXWZBsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTJ3OD60PUBvVQ>? MkjSV2FPT0WU
ES7 MkDOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnMTWM2OD1{N{OuNFkhdk1? MnLwV2FPT0WU
KY821 NYTqT2NHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUS0dG9uUUN3ME2zNVQvOSCwTR?= NGDCSXFUSU6JRWK=
RT-112 MmrqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;1[GlEPTB;M{KxMlA2KG6P M{XLcXNCVkeHUh?=
HL-60 M3K5cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTN2MD62OkBvVQ>? NEfhS4ZUSU6JRWK=
MOLT-4 Mon2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjwTJJKSzVyPUO0OU4yOyCwTR?= NXXVeWdvW0GQR1XS
KARPAS-45 NIj0THlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{noWmlEPTB;M{e2MlE3KG6P MmHqV2FPT0WU
SK-N-AS MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTN6Nz64N{BvVQ>? MmX4V2FPT0WU
CTB-1 NWrvZXFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDvb|ZNUUN3ME20NFUvODJibl2= NIfEcWRUSU6JRWK=
NKM-1 MmW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrzSY5KSzVyPUSxNU45QSCwTR?= NXnDNmo3W0GQR1XS
HTC-C3 NI\FelRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzNTWM2OD12M{KuPVUhdk1? NFLZR21USU6JRWK=
BE-13 M2r4cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHMNmhLUUN3ME20OFQvOjdibl2= MlvLV2FPT0WU
KOSC-2 NXztNZVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTR4Nj65JI5O NHGw[otUSU6JRWK=
NB14 M33oO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTR6Mz61PEBvVQ>? M1rpTXNCVkeHUh?=
CAL-27 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnnSnYxUUN3ME20PVQvPTlibl2= NYH4b3FbW0GQR1XS
H9 M1jLU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLUTWM2OD12OUWuOFMhdk1? MVHTRW5ITVJ?
RS4-11 M4q1Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEflTXpKSzVyPUWwOE44OyCwTR?= M{S2cXNCVkeHUh?=
PA-1 Ml;KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3RTWM2OD13MEmuPFYhdk1? MUHTRW5ITVJ?
MV-4-11 M1zmTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fuc2lEPTB;NUGzMlg2KG6P MVLTRW5ITVJ?
OS-RC-2 MnqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHST2VCUUN3ME21NlEvPjJibl2= MV\TRW5ITVJ?
RPMI-8226 Mn7VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTV{Nj64OkBvVQ>? Mn72V2FPT0WU
HGC-27 NWXaPJpxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HYSmlEPTB;NU[0Mlk6KG6P MYnTRW5ITVJ?
CHP-212 NFTpfJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTV7Mz61PUBvVQ>? M1vrSnNCVkeHUh?=
NB10 Mny3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHOVFdQUUN3ME21PVkvOThibl2= NUm0VppvW0GQR1XS
HH MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjWTWM2OD13OUmuOFMhdk1? M1\JcHNCVkeHUh?=
EW-16 M3;5XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTZyMz61NkBvVQ>? NWjjcmt7W0GQR1XS
ES8 NGDBNmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvxd2VmUUN3ME22NFUvOjFibl2= NFy3UJVUSU6JRWK=
HAL-01 M2nyemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTZyNT62O{BvVQ>? MoDLV2FPT0WU
A204 M2jLVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUL3R2lFUUN3ME22N|MvQTFibl2= NILXe|ZUSU6JRWK=
MHH-PREB-1 M4D3Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELGUXZKSzVyPU[zOk46QSCwTR?= MYTTRW5ITVJ?
EM-2 NGKzeYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfwe29qUUN3ME22OVAvPjRibl2= MlPZV2FPT0WU
BV-173 M{jZ[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoWxTWM2OD14NUKuOFghdk1? MYHTRW5ITVJ?
ONS-76 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXDTWM2OD14N{euPFIhdk1? NXPnV2VFW0GQR1XS
KM-H2 NYTPWnp4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnWeXEyUUN3ME22PVUvPTRibl2= NVWyfJNXW0GQR1XS
D-263MG Mn;GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvveHlyUUN3ME23NVcvOTJibl2= Mo\NV2FPT0WU
ES3 NE\ZbIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTkbHZHUUN3ME23NlgvQTNibl2= NGjFbmlUSU6JRWK=
VA-ES-BJ M{DDOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnnbmNKSzVyPUezNk4zPyCwTR?= NICyVGRUSU6JRWK=
NBsusSR NVSyNop4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVz6e2FPUUN3ME23OFIvQTlibl2= NULyemJyW0GQR1XS
NCI-H520 Mof4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTCc3B7UUN3ME23OFYvPTJibl2= M4C1NnNCVkeHUh?=
ES5 M{jKTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULXVHNkUUN3ME23OVIvQCCwTR?= NI\IR2lUSU6JRWK=
T-24 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzZT|lxUUN3ME23O|gvPzFibl2= MoTUV2FPT0WU
SW962 M1PzSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHZ[lhKSzVyPUiwPE43OyCwTR?= NWS2[o1wW0GQR1XS
EW-3 NF;JepRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nxNWlEPTB;OEC4Mlc3KG6P Mly0V2FPT0WU
RXF393 NUP1b2N3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnZTWM2OD16MUKuO|khdk1? MYHTRW5ITVJ?
U251 NETnepdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\JbVZKSzVyPUixN{45QCCwTR?= MorMV2FPT0WU
CAMA-1 M2rhbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHZTWM2OD16M{OuPVQhdk1? M3PFR3NCVkeHUh?=
JVM-3 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrCTWM2OD16NUGuO|ghdk1? NFPrPJVUSU6JRWK=
COLO-800 Mn6yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYX3flF5UUN3ME24PVcvPzhibl2= M2LjZXNCVkeHUh?=
OVCAR-5 NFizcVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHqyUnlKSzVyPUmwNE4yKG6P NEDZbppUSU6JRWK=
LB1047-RCC M4q3Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3:2XWlEPTB;OUK3MlU3KG6P NGC3RWRUSU6JRWK=
SW954 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPITZFrUUN3ME25NlkvPDFibl2= MnzkV2FPT0WU
J-RT3-T3-5 MkTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTl|Nj6wOkBvVQ>? NYTSWo5KW0GQR1XS
Mewo NUf4cGliT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTl|Nj62JI5O NFP1fnFUSU6JRWK=
NCI-H1770 NIDnbYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrqZWlKUUN3ME25OFAvPTVibl2= NGnybYNUSU6JRWK=
HO-1-N-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXETWM2OD17NkKuPFEhdk1? MY\TRW5ITVJ?
HSC-3 NVy5b|gxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUX2T|FWUUN3ME25OlYvPDhibl2= MXLTRW5ITVJ?
TYK-nu MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2WzZ2lEPTB;OUm4MlI2KG6P M1z3VXNCVkeHUh?=
KYSE-150 NEHpVpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvRTIp3UUN3ME2xMlAxODd4IN88US=> M{nEVHNCVkeHUh?=
SN12C MmnqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1v0eWlEPTB;MT6wNFg4PSEQvF2= NHHYeodUSU6JRWK=
MOLT-13 M2\yfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTFwMEG0NlEh|ryP M{nlVnNCVkeHUh?=
TE-11 M{fhd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTFwMES4NVIh|ryP MVfTRW5ITVJ?
DB M1r0ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnyRoN2UUN3ME2xMlA4Ojd|IN88US=> NYLzS5RpW0GQR1XS
CAL-39 NWHmTWhkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3xTWM2OD1zLkC3OVIzKM7:TR?= MXLTRW5ITVJ?
A3-KAW MlriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzDTWM2OD1zLkC4OFA5KM7:TR?= MYPTRW5ITVJ?
CHP-134 NGTmVHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HJRWlEPTB;MT6xNVgxPyEQvF2= MWTTRW5ITVJ?
TGW MmTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HXZ2lEPTB;MT6xNlM6PSEQvF2= NX\Jbox5W0GQR1XS
QIMR-WIL NWjkTGFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVH2TZBIUUN3ME2xMlE{OTN2IN88US=> NUTJNVViW0GQR1XS
NCI-SNU-1 NFTxNIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrQVmttUUN3ME2xMlE3OzV2IN88US=> NHW2b|VUSU6JRWK=
CGTH-W-1 MoLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPZUoFKSzVyPUGuNVcyQDZizszN MULTRW5ITVJ?
MHH-ES-1 NFe1U|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjiOWZKSzVyPUGuNVc6QDZizszN NGW5SGFUSU6JRWK=
LB2241-RCC Ml7TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;PfmRKSzVyPUGuNVg3OiEQvF2= NV3BdVVZW0GQR1XS
ML-2 NGi4TpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrU[HRKSzVyPUGuNlA4OzRizszN MkPwV2FPT0WU
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BFTC-905 NXLx[4lbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TDcGlEPTB;MT6yOFI3PyEQvF2= NGHGeYRUSU6JRWK=
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HEL M{HpWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XOb2lEPTB;MT6yPVM{QCEQvF2= MkXJV2FPT0WU
A549 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITMUJpKSzVyPUGuNlk{QTlizszN MWfTRW5ITVJ?
COLO-741 NIruRVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTETWM2OD1zLkOyNFg6KM7:TR?= MYnTRW5ITVJ?
PC-3 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVS2PIJ5UUN3ME2xMlM2OjJzIN88US=> MX3TRW5ITVJ?
HOS M3rHRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3DUJJKSzVyPUGuN|UzQTZizszN NYHHcVVLW0GQR1XS
HT-1080 M2Dlemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTFwM{e1NVkh|ryP NYi2epN7W0GQR1XS
TE-8 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTFwNEG3O|Qh|ryP NWfOemJIW0GQR1XS
BHY NUOyV5RET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HFdmlEPTB;MT60OlkzOyEQvF2= NVrPb2VlW0GQR1XS
BB65-RCC MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\nXlFSUUN3ME2xMlUxPTJ6IN88US=> MUHTRW5ITVJ?
HN MlPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWL3eoRYUUN3ME2xMlU1ODdzIN88US=> MYHTRW5ITVJ?
NCI-H441 NInkUohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVL2[JB{UUN3ME2xMlU1QTB5IN88US=> NILOXlNUSU6JRWK=
RPMI-8866 MoXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXlTWM2OD1zLkW4OVA4KM7:TR?= NYfreItkW0GQR1XS
CAL-62 MnTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrGTWM2OD1zLk[wPFYzKM7:TR?= NVnhNJJ3W0GQR1XS
MG-63 M4CzNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXyTWM2OD1zLk[xPFE{KM7:TR?= NHrTc|FUSU6JRWK=
SK-LU-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk[3TWM2OD1zLk[yNVUzKM7:TR?= NYHGcGN[W0GQR1XS
BCPAP NUToVI5uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGr5bIZKSzVyPUGuOlY1PTdizszN MnS0V2FPT0WU
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T47D NEjldoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\ZdmlEPTB;MT62PFA3OSEQvF2= MWjTRW5ITVJ?
MSTO-211H M3rkOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnzTWM2OD1zLk[5OlA{KM7:TR?= NXfTdGZHW0GQR1XS
DEL NEfieWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nZfWlEPTB;MT63NFI4OyEQvF2= NHroVXlUSU6JRWK=
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CAL-51 MmDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIH3XINKSzVyPUGuO|Q5PTVizszN M3LMS3NCVkeHUh?=
ABC-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\QTWM2OD1zLke4OVgzKM7:TR?= NEPM[YlUSU6JRWK=
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YKG-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{L0RWlEPTB;MT64NVA3OSEQvF2= MlfEV2FPT0WU
KM12 M1PrdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjkOVdUUUN3ME2xMlgyPjB{IN88US=> MX3TRW5ITVJ?
L-363 NIfmb3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTFwOEe0NVIh|ryP M{TzO3NCVkeHUh?=
KU812 NIrsdHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPkW4hKSzVyPUGuPFkzQDJizszN NXniTFdVW0GQR1XS
LOXIMVI NV;QNpNZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\KcGlEPTB;MT65NVIzQCEQvF2= MkD0V2FPT0WU
G-401 NU\TV4h1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3RTWM2OD1zLkmyOFI5KM7:TR?= M3XzcXNCVkeHUh?=
SW780 NUDwSlYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHvTWM2OD1zLkm2NlQ3KM7:TR?= NWXjcZgzW0GQR1XS
SW872 M3;1Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk[3TWM2OD1zLkm4N|Mh|ryP NWrtTopEW0GQR1XS
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T98G NWfBR2ZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3YTWM2OD1{LkCwOlY3KM7:TR?= NWPwWmJLW0GQR1XS
SW1710 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHGzd4FKSzVyPUKuNFY6PDVizszN MX3TRW5ITVJ?
NCI-H1573 MoXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVmyOFVrUUN3ME2yMlA4Ojl6IN88US=> NEjQbWZUSU6JRWK=
KE-37 NGLHUIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrRW2hzUUN3ME2yMlA5QTVzIN88US=> NIjMV5pUSU6JRWK=
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CAL-54 NGPiVmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXQTWM2OD1{LkKwOFE{KM7:TR?= M2\mN3NCVkeHUh?=
SF268 Ml;xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXr4S3J7UUN3ME2yMlI{OTJ{IN88US=> NUPnXGp1W0GQR1XS
SW620 NVvkWpE1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3Z[HNtUUN3ME2yMlI3OTZ7IN88US=> MWrTRW5ITVJ?
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NCI-H747 NIiwd3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjvTWM2OD1{LkOyNVk6KM7:TR?= M4DYV3NCVkeHUh?=
HCC2218 MkDaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEG1T|RKSzVyPUKuN|U{PzRizszN MXzTRW5ITVJ?
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EGI-1 NXnM[mtKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXG3SJBwUUN3ME2yMlQ3QDh|IN88US=> NHLzSlhUSU6JRWK=
CTV-1 M3zpd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rtbmlEPTB;Mj61Nlc4OyEQvF2= NFrqV|RUSU6JRWK=
NCI-H1355 NWHXWpR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLrWIRKSzVyPUKuOVU6PTFizszN NH;uPJBUSU6JRWK=
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RO82-W-1 NYH1Xpp4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTqVXRPUUN3ME2yMlYzODV5IN88US=> NGDo[|FUSU6JRWK=
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NUGC-3 NUDUXJkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nJd2lEPTB;Mj64NlUxPSEQvF2= M{fHRnNCVkeHUh?=
NCI-H292 NHvROWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHK[ndKSzVyPUKuPFUxPTNizszN MojrV2FPT0WU
Becker NET1TGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXaeWZzUUN3ME2yMlk2QDN{IN88US=> MnnjV2FPT0WU
NCI-H1299 M1XSNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;1TmRuUUN3ME2zMlA2OjZ|IN88US=> MlPBV2FPT0WU
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NCI-H209 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;B[WlEPTB;NT6yOVk1OiEQvF2= M1;GVnNCVkeHUh?=
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HD-MY-Z NF[1XI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjq[IdKSzVyPUG4MlIzPTRizszN MXrTRW5ITVJ?
A427 MnX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzOTWM2OD1zOD61NFk1KM7:TR?= NF;DcIdUSU6JRWK=
HCC2998 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoCwTWM2OD1zOD62NFUyKM7:TR?= MlnnV2FPT0WU
EPLC-272H M172VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTF7LkC0N|Qh|ryP MkPYV2FPT0WU
C32 NXvY[HlnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTF7LkC0OUDPxE1? M1TYcnNCVkeHUh?=
UMC-11 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;6NmlEPTB;MUmuNlEzOyEQvF2= M4nUPXNCVkeHUh?=
CaR-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LPZWlEPTB;MUmuOlgxPCEQvF2= MnPWV2FPT0WU
KYSE-410 M1nmdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYflcodPUUN3ME2xPU46OTN7IN88US=> M{LBV3NCVkeHUh?=
HuCCT1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofhTWM2OD1{MD62Nlk1KM7:TR?= M2fTUXNCVkeHUh?=
LB996-RCC MmPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\0[IpKSzVyPUKwMlcyPjhizszN MkSxV2FPT0WU
KYSE-70 NGW3fplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zvemlEPTB;MkCuPFA2QSEQvF2= NXG1WZc2W0GQR1XS
CAL-72 M2HRSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1[w[WlEPTB;MkCuPVE2KM7:TR?= MoLxV2FPT0WU
Capan-2 NIm3VnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTJzLkC0NVMh|ryP MUHTRW5ITVJ?
PANC-08-13 MonDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTNNolFUUN3ME2yNU4zPTF3IN88US=> MVvTRW5ITVJ?
SBC-1 NVjRXVJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXaOW1qUUN3ME2yNU4{ODhzIN88US=> MmnSV2FPT0WU
MFM-223 NXT5XVQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTJzLkOzOFIh|ryP NGfGVYZUSU6JRWK=
BB49-HNC NF;6WpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLQTWM2OD1{MT61O|E3KM7:TR?= MXrTRW5ITVJ?
SH-4 NWTPOoFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTJzLk[2NVgh|ryP M2XufnNCVkeHUh?=
HuO9 NYrxVXNWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkO0TWM2OD1{MT65PFI2KM7:TR?= M13Ke3NCVkeHUh?=
AM-38 NYnOb2pJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTJ{LkC0PFUh|ryP NUDwbFliW0GQR1XS
A431 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml34TWM2OD1{Mz6yNVE6KM7:TR?= MVPTRW5ITVJ?
YAPC NVr1VFZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTJ|LkK2OVEh|ryP M3zyOnNCVkeHUh?=
LU-139 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTJ|LkS4NFkh|ryP NF3XcJVUSU6JRWK=
HEC-1 NY\R[IRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfpXnhyUUN3ME2yN{41QTN5IN88US=> M2[1N3NCVkeHUh?=
SCC-25 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHWfWVJUUN3ME2yOE4{ODB4IN88US=> Mm\HV2FPT0WU
HT-29 MmTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWi3SJN5UUN3ME2yOE4{QDJ|IN88US=> MX;TRW5ITVJ?
PC-14 M2PXOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLXTWM2OD1{ND62OVcyKM7:TR?= NEPU[HJUSU6JRWK=
Calu-6 M2\iRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTJ3LkWwO|Eh|ryP MXLTRW5ITVJ?
SJRH30 M{TqeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPYNmg1UUN3ME2yOU43PDl4IN88US=> NInZTlNUSU6JRWK=
ChaGo-K-1 NUXEeHJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTJ4LkG2Nlkh|ryP M2jkenNCVkeHUh?=
IA-LM NH34PHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTJ4LkO2OFUh|ryP M3SyWHNCVkeHUh?=
GP5d NFe2VpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTJ4LkS0PVEh|ryP NF6ycWtUSU6JRWK=
NCI-H2291 NFj4WVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\kSmlEPTB;Mk[uOlU1OSEQvF2= NGrlR3VUSU6JRWK=
BALL-1 NUnTeohzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTJ4LkmzPVch|ryP MkO4V2FPT0WU
HCC1954 MlnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PYT2lEPTB;Mk[uPVgxQCEQvF2= NVX5d5kyW0GQR1XS
NCI-H2452 NHT3[oFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTJ5LkSxOlMh|ryP Ml;zV2FPT0WU
LU-99A NHK5fYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIH6NYVKSzVyPUK3MlU2QDJizszN MmjOV2FPT0WU
NTERA-S-cl-D1 M1vkZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFe3elNKSzVyPUK3MlczQTlizszN M{\pXHNCVkeHUh?=
PANC-10-05 NVTq[YFNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTJ5Lke3O|Uh|ryP NF7jOlRUSU6JRWK=
NCI-H2405 MmDES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoL5TWM2OD1{Nz65N|g4KM7:TR?= MWLTRW5ITVJ?
MDA-MB-415 NHLkO2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTJ6LkSxN|ch|ryP NYLWWVhiW0GQR1XS
NCI-H2342 NGfTXGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXycoVKSzVyPUK4MlUzQDFizszN NU[1XXE3W0GQR1XS
TGBC24TKB NXqwTpRyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nwVmlEPTB;MkiuO|EyPyEQvF2= NHvCW4lUSU6JRWK=
LU-134-A MmDKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfMeIFKSzVyPUK4MlkzPjFizszN NV[zVm9kW0GQR1XS
SCC-4 MmfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUW2RpJFUUN3ME2zNU4xPDl2IN88US=> NF[0O5VUSU6JRWK=
Saos-2 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIX6UWdKSzVyPUOxMlk{ODZizszN M1HaRnNCVkeHUh?=
RERF-LC-MS NHm5cppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTN{LkiyN|Eh|ryP MXfTRW5ITVJ?
M14 M2TTOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXzTWM2OD1|Mj65O|Y1KM7:TR?= M2TDfXNCVkeHUh?=
HPAF-II MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTN|LkWwNVEh|ryP NGDTc4dUSU6JRWK=
NCI-H1755 NFPy[YhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLUTWM2OD1|ND6zN|A2KM7:TR?= NH7DPHhUSU6JRWK=
D-392MG MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTN3Lki2O|Qh|ryP MmPUV2FPT0WU
A704 NILGVHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTN4LkC0Nlch|ryP M3O0ZnNCVkeHUh?=
CP50-MEL-B M3LDPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTN4LkG5NVEh|ryP NVTTSoxpW0GQR1XS
EW-18 NGixW|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\IWZdYUUN3ME2zOk41PTJizszN M1nZc3NCVkeHUh?=
WM-115 MoHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXzOFBKSzVyPUO2MlgxQTlizszN M4T4WHNCVkeHUh?=
LU-65 NE\6fm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTN5LkG0NVch|ryP NV7yW3hPW0GQR1XS
NCI-H1563 MnHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInOPGtKSzVyPUO3MlI1QDRizszN MoPKV2FPT0WU
DBTRG-05MG NIrUOXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGe0fVJKSzVyPUO4MlA3QTFizszN MWLTRW5ITVJ?
NCI-H630 Mm\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\ZemlEPTB;M{iuOFcyPCEQvF2= M2\KO3NCVkeHUh?=
NCI-H1155 MoX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4CwR2lEPTB;M{muNlQzKM7:TR?= M3K1UXNCVkeHUh?=
OVACR-3 M{TmTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{f5N2lEPTB;M{muPVE6PSEQvF2= MXvTRW5ITVJ?
OAW-42 MkHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVe0cot5UUN3ME20NE41OjV6IN88US=> NV\3cVZuW0GQR1XS
JVM-2 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nCXmlEPTB;NEGuNlQyPSEQvF2= MWnTRW5ITVJ?
C3A MnzDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTRzLkO0OFch|ryP Ml;VV2FPT0WU
HT55 MkXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPJTWM2OD12Mj6yPFQyKM7:TR?= M1XVW3NCVkeHUh?=
OVCAR-4 NGjxPYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE[4UHdKSzVyPUSyMlI6PzRizszN Mn\EV2FPT0WU
MEG-01 NGTTWm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTR{LkS2NVYh|ryP Mo\hV2FPT0WU
NCI-H82 NF2xdoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;5NGlEPTB;NEOuPVg6OiEQvF2= NUTLUoJzW0GQR1XS
JEG-3 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfsOm9KSzVyPUS0Mlk1PyEQvF2= MVzTRW5ITVJ?
BPH-1 NGXUcXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXjbI1vUUN3ME20Ok4{QTl6IN88US=> M2j3OHNCVkeHUh?=
MPP-89 MonIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2e1ZmlEPTB;NEeuNlg6QCEQvF2= NUjiUY9bW0GQR1XS
ALL-PO NW\WbZpMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXX4TlU{UUN3ME20O{41OTh6IN88US=> MmXUV2FPT0WU
HT NV7CeXhZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTR5LkS5NkDPxE1? MnLOV2FPT0WU
NCI-H2347 M13NXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrOc|NzUUN3ME20PE4xPzF3IN88US=> M2fqbXNCVkeHUh?=
A2780 M2fHdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWP4UodvUUN3ME20PU41OjJ6IN88US=> NFm5PWpUSU6JRWK=
KARPAS-299 NG\WOllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XscWlEPTB;NEmuOVEyQSEQvF2= M{\oTHNCVkeHUh?=
NCI-H1651 NILyZo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Dlb2lEPTB;NEmuPFgzOSEQvF2= NYDpcWk5W0GQR1XS

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
RB1 (pT821) / RB1 (pS780) / RB1 / CDK6 / CCND2 / RUNX1 / ETO; 

PubMed: 30300583     


Immunoblots showing dose-dependent impact of 72 hr palbociclib treatment on indicated protein levels in Kasumi-1 and SKNO-1 cells.

pRb(S807, 811) / CDK4 / CDK6 / PARP; 

PubMed: 28453226     


Effects of palbociclib on CDK4/6-Rb pathway. HCC cells were treated with different doses of palbociclib for 24 h, and then, the cells were subjected to western blot analysis. CF, cleaved fragment. 

LC3-I / LC3-II; 

PubMed: 28453226     


Palbociclib increases LC3-II amount in a dose-dependent manner in HCC cell lines. 

pAMPKα(T172) / pULK1(S317); 

PubMed: 28453226     


Dose-dependent response of palbociclib on AMPK-related molecules. HCC cells were treated with different concentrations of palbociclib for 24 h. The phosphorylation of the indicated proteins was determined by western blotting. 

SMAD2 (pS255); 

PubMed: 30343527     


T47D cells were treated with indicated concentrations of palbociclib for 24 h to evaluate substrate phosphorylation.

30300583 28453226 30343527
Growth inhibition assay
Cell viability; 

PubMed: 29670090     


Cell viability was determined by MTT assays after palbociclib exposure for 2, 4, and 6 days. The cell cycle of SYO-1 and Fuji cells was assessed after exposure to palbociclib (1 µM) for 24 h by flow cytometry analysis.

29670090
Immunofluorescence
SAHF/ATRX; 

PubMed: 26988987     


DAPI staining for senescence-associated heterochromatic foci (SAHF, left panel) and ATRX staining (right panel) in 1205Lu cells +/− palbociclib for 8 days. 

LC3B; 

PubMed: 28453226     


LC3B immunofluorescence in palbociclib‐treated Hep3B cells. Arrowheads indicate LC3-positive autophagosomes. Nuclei were counterstained with DAPI (blue).

26988987 28453226
ELISA
PGE2; 

PubMed: 26540629     


The supernatant of control and 7.5 μM palbociclib-treated cells was collected and stored at −80°C. PGE2 secretion was detected using ELISA.

26540629
体内研究 150 mg/kg PD 0332991处理 MDA-MB-435移植瘤完全抑制肿瘤。在多种人类肿瘤移植瘤中,PD 0332991也显示广谱抗癌活性,通过除去血管中p-Rb和增殖Marker Ki-67,且调节基因使其处于E2F转录水平控制。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

+ 展开

Cdk实验:

PD0332991溶解在DMSO中。在96孔板上进行CDK 实验。通过杆状病毒感染,所有的CDK-cyclin 激酶复合体 在昆虫细胞中表达。实验底物为与GST融合的一段pRb。每孔体积为0.1 ml,包含:终浓度为20 mm Tris-HCl(pH 为7.4), 50 mmNaCl, 1 mm二硫苏糖醇, 10 mmMgCl2, 25 μm ATP (用于CDK4-cyclin D1, CDK6-cyclin D2,和CDK6-cyclin D3)或12 μm ATP (用于CDK2-cyclin E, CDK2-cyclin A, 和CDC2-cyclin B),0.25 μCi [γ-32P]ATP, 20 ng 酶, 1 μg GST·RB-Cterm, 及PD 0332991 (0.001-0.1μM)。除了[γ-32P]ATP的所有混合物加到孔中,放在搅拌器上搅拌2分钟。加入 [γ-32P]ATP开始反应, 在25 oC下温育15分钟。加入0.1 ml 20% 三氯乙酸终止反应, 在4 oC维持至少1小时,使底物沉淀。用0.2 ml 10%三氯乙酸冲洗5次,用β-计数器板测定掺入的放射性。
细胞实验:

[1]

+ 展开
  • Cell lines: MDA-MB-435, ZR-75-1, T-47D, MCF-7, H1299, Colo-205, MDA-MB-468, H2009, CRRF-CEM,和K562细胞
  • Concentrations: 0.01-1 μM
  • Incubation Time: 24小时
  • Method:

    肿瘤细胞包括MDA-MB-435, ZR-75-1, T-47D, MCF-7, H1299, Colo-205, MDA-MB-468, H2009, CRRF-CEM,及K562按每孔2×104个细胞接种在96孔板上,温育过夜。加入PD 0332991 (0.01-1 μM) ,37oC温育24小时。每孔加入[14C]胸甘(0.1 μCi) ,进行同位素示踪,持续72小时。用β-计数器板测定掺入的放射性。


    (Only for Reference)
动物实验:

[1]

+ 展开
  • Animal Models: 携带晚期人类肿瘤移植瘤,包括结肠-205, MDA-MB-435 乳腺癌, SF-295 恶性胶质瘤, ZR-75-1 乳腺癌, PC-3 前列腺癌, H125 肺癌, SW-620结肠癌, H23肺癌,及MDA-MB-468 乳腺癌 (Rb 阴性)的SCID鼠
  • Formulation: 溶解在乳酸钠buffer(50 mM, pH 4.0)中
  • Dosages: 0-150 mg/kg
  • Administration: 口服饲喂
    (Only for Reference)

溶解度 (25°C)

体外 Water 30 mg/mL (61.98 mM)
DMSO 3 mg/mL warmed (6.19 mM)
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
Saline
6 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 483.99
化学式

C24H29N7O2.HCl

CAS号 827022-32-2
储存条件 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03870919 Not yet recruiting Breast Cancer Stage IV|Radiotherapy|Surgery UNICANCER|Pfizer October 15 2019 Not Applicable
NCT03900884 Not yet recruiting Breast Neoplasm Female Peter MacCallum Cancer Centre Australia September 2019 Phase 1
NCT03844997 Recruiting Acute Myeloid Leukemia|AML Aziz Nazha|Case Comprehensive Cancer Center May 31 2019 Phase 1|Phase 2

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CDK Signaling Pathway Map

CDK Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID