Palbociclib (PD-0332991) HCl

For research use only. Not for use in humans.

Pfizer辉瑞授权 目录号:S1116

Palbociclib (PD-0332991) HCl Chemical Structure

CAS No. 827022-32-2

Palbociclib (PD-0332991) HCl是一种高度选择性的CDK4/6抑制剂,无细胞试验中IC50分别为11 nM/16 nM。它对CDK1/2/5,EGFR,FGFR,PDGFR,InsR等没有抑制活性。Phase 3。

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客户使用Selleck生产的Palbociclib (PD-0332991) HCl发表文献215篇:

产品安全说明书

CDK抑制剂选择性比较

生物活性

产品描述 Palbociclib (PD-0332991) HCl是一种高度选择性的CDK4/6抑制剂,无细胞试验中IC50分别为11 nM/16 nM。它对CDK1/2/5,EGFR,FGFR,PDGFR,InsR等没有抑制活性。Phase 3。
特性 PD-0332991作为有应用前景的工具测定CDK激酶是否具有明显的治疗价值。
靶点
CDK4/CyclinD3 [1]
(Cell-free assay)
CDK4/CyclinD1 [1]
(Cell-free assay)
CDK6/CyclinD2 [1]
(Cell-free assay)
9 nM 11 nM 15 nM
体外研究

PD 0332991 对其他蛋白激酶包括EGFR, FGFR, PGFR, IR等没有抑制效果。 PD 0332991作用于Cdk4时是非ATP竞争性抑制剂。PD 0332991抑制MDA-MB-435乳腺癌细胞,IC50为66 nM,是由于Rb 在Ser780的磷酸化作用下降。PD 0332991抑制胸苷合并到Rb阳性的人类乳腺癌,结肠癌 肺癌,及白血病的DNA中,IC50值为4 nM到0.17 μM。PD 0332991作用于Rb阴性细胞没有抑制效果。PD 0332991作用于MDA-MB-453乳腺癌细胞和结肠-205细胞使细胞积累在G1期。[1]PD 0332991也有效作用于骨髓瘤5T33MM细胞,使细胞对Bortezomib敏感。[2]PD 0332991抑制luminalER-阳性和HER2-增强的乳腺癌细胞系,包括MDA-MB-175 ZR-75-30 CAMA-1 MDA-MB-134 HCC-202 UACC-893 等等。在这些细胞系中,PD 0332991增强Tamoxifen和Trastuzumab 的活性。在MCF7抗Tamoxifen细胞中,PD 0332991也增强tamoxifen 的敏感性。[3] 最新研究显示PD 0332991可以抑制恶性横纹肌样肿瘤(MRT)细胞系包括MP-MRT-AN, KP-MRT-RY, G401, KP-MRT-NS,且MRT细胞系对PD 0332991敏感性和p16表达呈负相关。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MOLM13 M4XpcmtqdmG|ZTDBd5NigQ>? MmHRNlQhcA>? MV3Jcohq[mm2aX;uJI9nKEOGS{SgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDSZkBxcG:|cHjvdplt[XSrb36ge4l1cCCLQ{WwJI9nKDBwMECyJO69VQ>? NXi3[G11OjR4NEGxNFM>
COLO205 NXfvUItVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPVSow4OiCq NXGzeZVjSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|ZYPz[YQh[XNiaX7jc5Jxd3KjdHnvckBw\iCdM1jdeIh6dWmmaX7lJIlvfG9iRF7BJJdqfGhiSVO1NEBw\iByLkCzOkDPxE1? M3nhd|I1PjRzMUCz
U937 M3nNNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHOPYJVPzJiaB?= M2LaOmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2W|c3XkJIF{KGmwY3;ydI9z[XSrb36gc4YhYzOKXYTofY1q\GmwZTDpcpRwKESQQTD3bZRpKEmFNUCgc4YhOC5zNDFOwG0> M3v3c|I1PjRzMUCz
MOLM13 NHrRSJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPQOo44OiCq MlXkRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPT1zNNVMh[2WubIOgbIFz[m:{aX7nJGZNXDNiSWTEJI12fGGwdDDhd5Nme3OnZDDhd{BqdmOxcoDvdoF1cW:wIH;mJHs{UF22aIntbYRqdmViaX70c{BFVkFid3n0bEBKSzVyIH;mJFAvODl4IN88US=> M3zLWFI1PjRzMUCz
MOLM13 NU\rTYZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3S3S|czKGh? MW\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IIPvdoFn\W6rYj3y[ZNqe3SjboSgbJVu[W5iTV;MUVE{KGOnbHzzJIF{e2W|c3XkJIF{KGmwY3;ydI9z[XSrb36gc4YhYzOKXYTofY1q\GmwZTDpcpRwKESQQTD3bZRpKEmFNUCgc4YhOC5yOU[g{txO Mo\VNlQ3PDFzMEO=
MDA-MB-435 MnH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvZNlQhcA>? NX\DV2RqUUN3ME2wMlE3KM7:TR?= MoLWNVU5ODF6M{G=
K562 M4HDRmN6fG:2b4jpZ{BCe3OjeR?= NV3D[nVGQTZiaB?= M3rlcmROW09? NIjVUppKSzVyPUKg{txO M1HIblI1PDF5NU[2
DU145 M4r1TGN6fG:2b4jpZ{BCe3OjeR?= NUfP[FhVQTZiaB?= NI\5bIRFVVOR MXrJR|UxRTdwNTFOwG0> M{\0VFI1PDF5NU[2
MDA-MB-231 MnjDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XKeVEh|ryP NF\qc4EzPCCq MXjEUXNQ NY\Mcm5JS2WubDDjfYNt\SCjcoLld5Qh[XO|ZYPz[YQh[XNiYXPjeY12dGG2aX;uJIF1KEdzIIDoZZNm NIPCXIszPDRzN{W2Oi=>
MCF7 M2\lNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfXNUDPxE1? Mk\vNlQhcA>? MYPEUXNQ MVLD[YxtKGO7Y3zlJIFzemW|dDDhd5Nme3OnZDDhd{Bi[2O3bYXsZZRqd25iYYSgS|EheGijc3W= MmmwNlQ1OTd3Nk[=
MCF7 NWPqUmQ{U2mwYYPlJGF{e2G7 MUK1JO69VQ>? MXWyOEBp MUDEUXNQ NIHjfYJKdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JGNFUzRxY4njcIlvTDFiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC{ZYTpco9jdGG|dH;tZUBxcG:|cHjvdplt[XSrb36gZZQhW2W{N{iw MVGyOFQyPzV4Nh?=
MDA-MB-231 MoLZT4lv[XOnIFHzd4F6 M{HF[VUh|ryP MWiyOEBp MorHSG1UVw>? NY\WS5dNUW6qaXLpeIlwdiCxZjDy[YNwdWKrbnHueEBETEt2L3P5Z4xqdkRzIHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZicnX0bY5w[myjc4TvcYEheGixc4Doc5J6dGG2aX;uJIF1KFOncke4NC=> MW[yOFQyPzV4Nh?=
MDA-MB-231 NIjNRpdHfW6ldHnvckBCe3OjeR?= M1XESlEuOTBizszN NYLzfmRmOjRiaB?= M{PpSWROW09? MlzS[I9meyCwb4SgbY5lfWOnIHHwc5B1d3OrczDhd5Nme3OnZDDhd{BRSVKSIHPs[YF3[Wen NEPrd40zPDRzN{W2Oi=>
MCF7 MUfGeY5kfGmxbjDBd5NigQ>? M1\RUlEuOTBizszN MV:yOEBp Mn:zSG1UVw>? NX3XRlNz\G:nczDuc5QhcW6mdXPlJIFxd3C2b4Ppd{Bie3Onc4Pl[EBieyCSQWLQJINt\WG4YXfl NXLSbGlnOjR2MUe1OlY>
MDA-MB-231 NGrZ[phHfW6ldHnvckBCe3OjeR?= NIXUXJIxNjVvMTFOwG0> NWjYXo9qPDhiaB?= NW[yUIN7TE2VTx?= NU\mNFFzcGG|IH7vJGNmdGxiY4njcIUh[XK{ZYP0JIF{e2W|c3XkJIF{KGGlY4XteYxifGmxbjDheEB{fWJvR{GgdIhie2V? NF;oUlAzPDRzN{W2Oi=>
MCF7 M2PHbWZ2dmO2aX;uJGF{e2G7 NHrJTo4xNjVvMTFOwG0> MV:0PEBp NHnZflBFVVOR NFjTPZVp[XNibn:gR4VtdCCleXPs[UBienKnc4SgZZN{\XO|ZXSgZZMh[WOldX31cIF1cW:wIHH0JJN2[i2JMTDwbIF{\Q>? NF\oWZQzPDRzN{W2Oi=>
697 NVvONZZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnm2TWM2OD1zNEiuN|ghdk1? MXLTRW5ITVJ?
P12-ICHIKAWA Ml3KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPKVYpKSzVyPUm2MlA1KG6P NVT0dFBoW0GQR1XS
NB69 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHqxTppKSzVyPUG2NU45KG6P NF7ieGpUSU6JRWK=
EoL-1 NWm3dHgyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTF6Nz6yOkBvVQ>? MljwV2FPT0WU
BHT-101 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTF7OD6yOUBvVQ>? NH7GPJlUSU6JRWK=
SK-NEP-1 M3;sfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkW1TWM2OD1{MkCuNFIhdk1? Mlr0V2FPT0WU
MHH-NB-11 MnrQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTJ{MD6xPUBvVQ>? NHq1b|ZUSU6JRWK=
AsPC-1 M{CyR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\lUmlEPTB;MkWyMlU{KG6P MUDTRW5ITVJ?
ES1 M1y1eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{njV2lEPTB;MkW2MlI2KG6P NYfwNo5HW0GQR1XS
LAMA-84 NYH1e3VDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHERpV1UUN3ME2yOVgvOTlibl2= NEPnUWZUSU6JRWK=
MOLT-16 M3;WWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3NWYFGUUN3ME2yOVgvPDlibl2= NYO1N4p3W0GQR1XS
ES7 NVz4fXh3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWH2OlM5UUN3ME2yO|MvODlibl2= MlPsV2FPT0WU
KY821 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTNzND6xJI5O NH;EdlFUSU6JRWK=
RT-112 M2XkN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWS4eFRmUUN3ME2zNlEvODVibl2= MlH1V2FPT0WU
HL-60 M2TLe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDlOGt3UUN3ME2zOFAvPjZibl2= NGrJVVNUSU6JRWK=
MOLT-4 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTN2NT6xN{BvVQ>? M17DNXNCVkeHUh?=
KARPAS-45 NHvhUVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTN5Nj6xOkBvVQ>? NWjEWpB5W0GQR1XS
SK-N-AS MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH:zT29KSzVyPUO4O{45OyCwTR?= M1;sVXNCVkeHUh?=
CTB-1 M3S2OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3f0dmlEPTB;NEC1MlAzKG6P MX;TRW5ITVJ?
NKM-1 NETG[oNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXHTWM2OD12MUGuPFkhdk1? NYroSIxQW0GQR1XS
HTC-C3 M{TvSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{n1TGlEPTB;NEOyMlk2KG6P M2rvdHNCVkeHUh?=
BE-13 Mn7yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnZUHprUUN3ME20OFQvOjdibl2= MnfjV2FPT0WU
KOSC-2 NWmzV|lnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2K3bGlEPTB;NE[2Mlkhdk1? NHixN2hUSU6JRWK=
NB14 M3z0cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjOeG81UUN3ME20PFMvPThibl2= NHHkS4dUSU6JRWK=
CAL-27 NU\QdYpmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkK5TWM2OD12OUSuOVkhdk1? MXvTRW5ITVJ?
H9 NWWyNoM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfXZ4wxUUN3ME20PVUvPDNibl2= NHXIXZFUSU6JRWK=
RS4-11 M4LaVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\PTWM2OD13MESuO|Mhdk1? NYjZWJhFW0GQR1XS
PA-1 Mnu3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXxTWM2OD13MEmuPFYhdk1? MXzTRW5ITVJ?
MV-4-11 MmHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVP2NoFKUUN3ME21NVMvQDVibl2= NUP5dnlPW0GQR1XS
OS-RC-2 NXK1XnFIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEm5XmhKSzVyPUWyNU43OiCwTR?= MknyV2FPT0WU
RPMI-8226 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPKWYd3UUN3ME21NlYvQDZibl2= NEf0UYlUSU6JRWK=
HGC-27 NF3USIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljZTWM2OD13NkSuPVkhdk1? NXf6b3VyW0GQR1XS
CHP-212 NUK0dnJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX20[3M1UUN3ME21PVMvPTlibl2= MnzPV2FPT0WU
NB10 NFn6bZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzZUoFKSzVyPUW5PU4yQCCwTR?= MlXwV2FPT0WU
HH MnP5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jNWmlEPTB;NUm5MlQ{KG6P M3TGU3NCVkeHUh?=
EW-16 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrITWM2OD14MEOuOVIhdk1? NW\DdlR5W0GQR1XS
ES8 M37Eb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\ZRmlEPTB;NkC1MlIyKG6P NEDGdJNUSU6JRWK=
HAL-01 M{XpfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTZyNT62O{BvVQ>? MUjTRW5ITVJ?
A204 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\wc4lKSzVyPU[zN{46OSCwTR?= MYTTRW5ITVJ?
MHH-PREB-1 MnLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfkTWM2OD14M{[uPVkhdk1? NWfjPJFFW0GQR1XS
EM-2 M{jLTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLpTWM2OD14NUCuOlQhdk1? NEPhblBUSU6JRWK=
BV-173 M3XWVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPvTWM2OD14NUKuOFghdk1? NUe3WoM6W0GQR1XS
ONS-76 MmHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1X5VmlEPTB;Nke3MlgzKG6P Mn65V2FPT0WU
KM-H2 MkPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTZc49wUUN3ME22PVUvPTRibl2= NVH4Z5RLW0GQR1XS
D-263MG NHHFbYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnieIRWUUN3ME23NVcvOTJibl2= NWXPRVNIW0GQR1XS
ES3 NHTOSnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTd{OD65N{BvVQ>? M3iySHNCVkeHUh?=
VA-ES-BJ NIDDV3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1u2NGlEPTB;N{OyMlI4KG6P NELXcGhUSU6JRWK=
NBsusSR NHHhOHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTd2Mj65PUBvVQ>? M1rYOHNCVkeHUh?=
NCI-H520 NEnkVFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfUTWM2OD15NE[uOVIhdk1? Mkf2V2FPT0WU
ES5 Mm\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1y2[mlEPTB;N{WyMlghdk1? MojxV2FPT0WU
T-24 M4P5c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PHVmlEPTB;N{e4MlcyKG6P NVvwSoE1W0GQR1XS
SW962 NYDi[4FRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfCU5c6UUN3ME24NFgvPjNibl2= Mn7XV2FPT0WU
EW-3 NXnUOGROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPLT4JKSzVyPUiwPE44PiCwTR?= NInzUmtUSU6JRWK=
RXF393 NXHXdHBkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrDTYtKSzVyPUixNk44QSCwTR?= NXjUSoM{W0GQR1XS
U251 NHfzWI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTETmNTUUN3ME24NVMvQDhibl2= MVHTRW5ITVJ?
CAMA-1 NEWwWmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXIe2JKSzVyPUizN{46PCCwTR?= MofuV2FPT0WU
JVM-3 MnnGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnKTZNKSzVyPUi1NU44QCCwTR?= M32yPHNCVkeHUh?=
COLO-800 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnrTWM2OD16OUeuO|ghdk1? M1i3[HNCVkeHUh?=
OVCAR-5 NXz2WoZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1OyV2lEPTB;OUCwMlEhdk1? NXToSWlJW0GQR1XS
LB1047-RCC MnzTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTVTWM2OD17MkeuOVYhdk1? M{XyT3NCVkeHUh?=
SW954 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXn6Xo51UUN3ME25NlkvPDFibl2= MnP0V2FPT0WU
J-RT3-T3-5 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfS[2RKSzVyPUmzOk4xPiCwTR?= M2nCbXNCVkeHUh?=
Mewo MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LlOWlEPTB;OUO2MlYhdk1? M2H5b3NCVkeHUh?=
NCI-H1770 NWfUWmFQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\JTGlEPTB;OUSwMlU2KG6P NH:4[oJUSU6JRWK=
HO-1-N-1 NWXIT5A1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzsOW1KSzVyPUm2Nk45OSCwTR?= M2DSSHNCVkeHUh?=
HSC-3 NIXiTXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHsTWM2OD17Nk[uOFghdk1? M2XrWnNCVkeHUh?=
TYK-nu M2e2S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTl7OD6yOUBvVQ>? NWTk[INEW0GQR1XS
KYSE-150 M1TLRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTFwMECwO|Yh|ryP MkLYV2FPT0WU
SN12C MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHrTWM2OD1zLkCwPFc2KM7:TR?= M13KXHNCVkeHUh?=
MOLT-13 NXqweItNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzaTWM2OD1zLkCxOFIyKM7:TR?= NGTzT3NUSU6JRWK=
TE-11 M2LK[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37ybmlEPTB;MT6wOFgyOiEQvF2= MVnTRW5ITVJ?
DB NXHXSZV7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHHTWM2OD1zLkC3Nlc{KM7:TR?= NWnIeXliW0GQR1XS
CAL-39 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXkSXQxUUN3ME2xMlA4PTJ{IN88US=> MX7TRW5ITVJ?
A3-KAW NFTQZoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;uTWM2OD1zLkC4OFA5KM7:TR?= Ml;3V2FPT0WU
CHP-134 NFTxVZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTFwMUG4NFch|ryP NEHQOodUSU6JRWK=
TGW NXj2cWhST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLEVpN3UUN3ME2xMlEzOzl3IN88US=> MmT3V2FPT0WU
QIMR-WIL NETpPW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHwcItxUUN3ME2xMlE{OTN2IN88US=> NXHzTXV7W0GQR1XS
NCI-SNU-1 M3LHOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTFwMU[zOVQh|ryP MkPaV2FPT0WU
CGTH-W-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;a[nVKSzVyPUGuNVcyQDZizszN NVjFNo5JW0GQR1XS
MHH-ES-1 M{HDcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrwTWM2OD1zLkG3PVg3KM7:TR?= MVTTRW5ITVJ?
LB2241-RCC NFzwOmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17OXGlEPTB;MT6xPFYzKM7:TR?= NUPrbHh{W0GQR1XS
ML-2 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrGO3pKSzVyPUGuNlA4OzRizszN M13lOnNCVkeHUh?=
COR-L23 M3fNcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlr0TWM2OD1zLkKyPVM{KM7:TR?= MX;TRW5ITVJ?
BFTC-905 MofFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1W2TmlEPTB;MT6yOFI3PyEQvF2= NUnZZXV6W0GQR1XS
Hs-578-T MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTFwMkW4NVch|ryP MkT5V2FPT0WU
KG-1 NEPnbVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPmOJRsUUN3ME2xMlI3Pjh4IN88US=> NI\GcppUSU6JRWK=
HEL NViyb2NuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHPTpJOUUN3ME2xMlI6OzN6IN88US=> NGC0UHpUSU6JRWK=
A549 NIjMTVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrNTWM2OD1zLkK5N|k6KM7:TR?= MYfTRW5ITVJ?
COLO-741 NIXofmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LHbGlEPTB;MT6zNlA5QSEQvF2= NIS5O2NUSU6JRWK=
PC-3 M3vlcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTFwM{WyNlEh|ryP MkOxV2FPT0WU
HOS MmDvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTFwM{WyPVYh|ryP M{mzXHNCVkeHUh?=
HT-1080 M3jiXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3H1bmlEPTB;MT6zO|UyQSEQvF2= MV;TRW5ITVJ?
TE-8 M4HzOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nGPGlEPTB;MT60NVc4PCEQvF2= Mny0V2FPT0WU
BHY NHvzb4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYWyZ49oUUN3ME2xMlQ3QTJ|IN88US=> NWrBW4FoW0GQR1XS
BB65-RCC MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2j0fGlEPTB;MT61NFUzQCEQvF2= M4D5SnNCVkeHUh?=
HN M4nHNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vSNGlEPTB;MT61OFA4OSEQvF2= NVTzelZFW0GQR1XS
NCI-H441 NUHYSY03T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPiWpVZUUN3ME2xMlU1QTB5IN88US=> MmL3V2FPT0WU
RPMI-8866 M2\BT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DBXGlEPTB;MT61PFUxPyEQvF2= NXPzZZJvW0GQR1XS
CAL-62 Ml[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjRTWM2OD1zLk[wPFYzKM7:TR?= NF62WXBUSU6JRWK=
MG-63 NETtOXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXMSVJKSzVyPUGuOlE5OTNizszN MULTRW5ITVJ?
SK-LU-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nOdWlEPTB;MT62NlE2OiEQvF2= NXTqRodtW0GQR1XS
BCPAP NXO1c4d2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETvV2pKSzVyPUGuOlY1PTdizszN M1;JeHNCVkeHUh?=
22RV1 NFnmUnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVr2V4VvUUN3ME2xMlY4QDR|IN88US=> Mnz1V2FPT0WU
T47D MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzuRpU4UUN3ME2xMlY5ODZzIN88US=> MXTTRW5ITVJ?
MSTO-211H NIjsOlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTFwNkm2NFMh|ryP M{G3VHNCVkeHUh?=
DEL NIrNW4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHyzZ3FKSzVyPUGuO|AzPzNizszN M{PKOHNCVkeHUh?=
H4 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTFwN{OyNVIh|ryP NYjyZZpwW0GQR1XS
CAL-51 MkDaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTFwN{S4OVUh|ryP MYfTRW5ITVJ?
ABC-1 M4\Demdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rUPWlEPTB;MT63PFU5OiEQvF2= M1W0cXNCVkeHUh?=
MZ2-MEL M2[2PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXifFh1UUN3ME2xMlc6PTR{IN88US=> M1fGOHNCVkeHUh?=
YKG-1 NXvJToNvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFT6TGFKSzVyPUGuPFExPjFizszN NGfkPGJUSU6JRWK=
KM12 NVfDR|k4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLPTWM2OD1zLkixOlAzKM7:TR?= NVWxRpJMW0GQR1XS
L-363 M3fYbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTFwOEe0NVIh|ryP NVu5NVQ2W0GQR1XS
KU812 M3vSeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXm3fGNTUUN3ME2xMlg6Ojh{IN88US=> MYfTRW5ITVJ?
LOXIMVI MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\hTWM2OD1zLkmxNlI5KM7:TR?= NVnOeYxXW0GQR1XS
G-401 NXrWblJzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfCUXlKSzVyPUGuPVI1OjhizszN M4rMVnNCVkeHUh?=
SW780 M1XMcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TNPWlEPTB;MT65OlI1PiEQvF2= MYXTRW5ITVJ?
SW872 MkLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHZPXREUUN3ME2xMlk5OzNizszN MWXTRW5ITVJ?
NB7 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LzdWlEPTB;MT65PVMzOyEQvF2= NYLOe3RFW0GQR1XS
T98G NEfZVVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\rTWM2OD1{LkCwOlY3KM7:TR?= NHf4SodUSU6JRWK=
SW1710 NHnhTFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTJwME[5OFUh|ryP MnrnV2FPT0WU
NCI-H1573 M3zWN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmGxTWM2OD1{LkC3Nlk5KM7:TR?= MXPTRW5ITVJ?
KE-37 MnvFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTJwMEi5OVEh|ryP NVjUNVg{W0GQR1XS
786-0 M1PXb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTGTWM2OD1{LkG1OFM6KM7:TR?= MWnTRW5ITVJ?
SAS M4C3TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTJwMkCzO|Qh|ryP M2j0XHNCVkeHUh?=
CAL-54 MmH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHGN4lrUUN3ME2yMlIxPDF|IN88US=> NEfnOGdUSU6JRWK=
SF268 M{LOTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vrTGlEPTB;Mj6yN|EzOiEQvF2= Ml36V2FPT0WU
SW620 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPGcXhKSzVyPUKuNlYyPjlizszN NEjZUI9USU6JRWK=
MN-60 NEnDTFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33PRmlEPTB;Mj6zNVA3KM7:TR?= MnjIV2FPT0WU
EFO-27 M{TUc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDmTWM2OD1{LkOyNFU5KM7:TR?= MWfTRW5ITVJ?
NCI-H747 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTJwM{KxPVkh|ryP M{P5NXNCVkeHUh?=
HCC2218 NWjUUodQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fUcGlEPTB;Mj6zOVM4PCEQvF2= MkfvV2FPT0WU
MIA-PaCa-2 M4XqNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;q[|B2UUN3ME2yMlM3PDN5IN88US=> NX31W|FGW0GQR1XS
SJSA-1 M4jvSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnT6TWM2OD1{LkO3O|k3KM7:TR?= NXrB[Gc3W0GQR1XS
RKO NWK3PWN5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW[xfY95UUN3ME2yMlM5PDl4IN88US=> MYXTRW5ITVJ?
NB6 M{\BU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHVTWM2OD1{LkSwN|c1KM7:TR?= M3nsdHNCVkeHUh?=
ES4 NYHqfHJyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Po[GlEPTB;Mj60OVQzOiEQvF2= NFT4VmRUSU6JRWK=
EGI-1 M4r6Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTkTWM2OD1{LkS2PFg{KM7:TR?= MmLKV2FPT0WU
CTV-1 NIK5VJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;h[VBKSzVyPUKuOVI4PzNizszN M3mwc3NCVkeHUh?=
NCI-H1355 NEe1VWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4n5UmlEPTB;Mj61OVk2OSEQvF2= M37NfHNCVkeHUh?=
GT3TKB M4Sx[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXMTWM2OD1{LkW5NVk6KM7:TR?= MlG0V2FPT0WU
SK-HEP-1 Ml\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTJwNUmyOlYh|ryP MXjTRW5ITVJ?
GAMG Mk\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTJwNUmzPVQh|ryP NH;oc2NUSU6JRWK=
SK-MES-1 MmXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTJwNkG4NFMh|ryP NHnMc|ZUSU6JRWK=
RO82-W-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTmTWM2OD1{Lk[yNFU4KM7:TR?= M3z1NHNCVkeHUh?=
ECC10 MlK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLRNmp5UUN3ME2yMlcxOjB4IN88US=> NWrOUGwyW0GQR1XS
MCF7 M4nKe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoT1TWM2OD1{LkexOFY1KM7:TR?= NXv0VmJZW0GQR1XS
D-283MED M4HQc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH[0bW1KSzVyPUKuO|I1OyEQvF2= NEPodGpUSU6JRWK=
RPMI-7951 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTJwN{W2PVQh|ryP MUPTRW5ITVJ?
Ramos-2G6-4C10 MoP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHNfJhFUUN3ME2yMlc4ODl7IN88US=> NWLUZopiW0GQR1XS
KGN MoDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3oZVJKUUN3ME2yMlgyQDh2IN88US=> NYHHeJlqW0GQR1XS
NUGC-3 NHXsfFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXqdFFHUUN3ME2yMlgzPTB3IN88US=> NYj5U5k6W0GQR1XS
NCI-H292 Mmj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUL4fmY2UUN3ME2yMlg2ODV|IN88US=> NV3yUYdvW0GQR1XS
Becker MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVToPHBxUUN3ME2yMlk2QDN{IN88US=> NEXH[2lUSU6JRWK=
NCI-H1299 MmTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVu2UGJqUUN3ME2zMlA2OjZ|IN88US=> M3yyWHNCVkeHUh?=
ETK-1 NIrYRmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\tWYhKSzVyPUOuNFU1OyEQvF2= NEnrdWtUSU6JRWK=
TK10 NH;0bItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn24TWM2OD1|LkKwNVY2KM7:TR?= NVW2Tno6W0GQR1XS
VMRC-RCZ NHu5OWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnziTWM2OD1|LkO2OFg5KM7:TR?= NFf6NoJUSU6JRWK=
YH-13 NH[yXWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTIdopTUUN3ME2zMlQ1ODd7IN88US=> MWrTRW5ITVJ?
DU-145 NVqxbYpxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHlXVd1UUN3ME2zMlQ3OjZ7IN88US=> MmrHV2FPT0WU
SW1088 NWi5UVRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTNwNEe0O{DPxE1? M4fUUXNCVkeHUh?=
HOP-92 M4O3cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jofWlEPTB;Mz61NFM1OiEQvF2= M1vDbnNCVkeHUh?=
KP-N-YS MnjJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrmU4ppUUN3ME2zMlYzOTN7IN88US=> NV3ENnR[W0GQR1XS
NCI-H460 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4K5dmlEPTB;Mz62Olc{KM7:TR?= MYrTRW5ITVJ?
U-2-OS MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnqRWU{UUN3ME2zMlczPTN3IN88US=> NYG0[YNZW0GQR1XS
A101D NGK4[YJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTNwN{[5N|Yh|ryP NEnDT|VUSU6JRWK=
MDA-MB-231 NUnNRZdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1u1RWlEPTB;Mz64NVk2OSEQvF2= M1;yVXNCVkeHUh?=
IST-MES1 Mlq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{D1eGlEPTB;Mz64N|Ih|ryP NXS4THBTW0GQR1XS
COR-L105 M2jwUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnPTWM2OD12LkCxPEDPxE1? NWPDemVIW0GQR1XS
NCI-H1437 NF25bIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jYbmlEPTB;ND6wNlMxOiEQvF2= MUXTRW5ITVJ?
CAL-85-1 NGKwcpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDLbFU4UUN3ME20MlAzPDZzIN88US=> M1voZ3NCVkeHUh?=
MZ1-PC NVzpVYMyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTDV|RFUUN3ME20MlE5PTV4IN88US=> MYPTRW5ITVJ?
VM-CUB-1 MmWzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PMbGlEPTB;ND6zNVI5PCEQvF2= NXP2[3FEW0GQR1XS
CHL-1 Ml;6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTRwM{KxOlkh|ryP NGHIWHlUSU6JRWK=
MDA-MB-361 Mlv2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jSRWlEPTB;ND6zN|E2OyEQvF2= NE\lPHFUSU6JRWK=
NCI-H661 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDucmZKSzVyPUSuOVAxQTJizszN M3LN[HNCVkeHUh?=
EW-11 M13MZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PyWmlEPTB;ND61NlI{OSEQvF2= NH3INJRUSU6JRWK=
BEN NIP6dG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\3dogyUUN3ME20MlUzQDF3IN88US=> NFH1XmJUSU6JRWK=
BFTC-909 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTRwNU[yO|Uh|ryP MoHaV2FPT0WU
NCI-H2087 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLoZmo3UUN3ME20MlU5OTZ2IN88US=> NEHncI1USU6JRWK=
RVH-421 MnfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk[5TWM2OD12Lk[2Olkh|ryP MUnTRW5ITVJ?
P30-OHK NX;VZZlQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPOTWM2OD12Lk[4NFA5KM7:TR?= MVTTRW5ITVJ?
NCI-H28 NEjhO|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\VTWM2OD12LkixOlYyKM7:TR?= NYXrdVhiW0GQR1XS
ES6 MnjhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\TVWlEPTB;ND64N|AyPiEQvF2= MnnEV2FPT0WU
769-P MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7KVmJRUUN3ME20Mlg2QTJ4IN88US=> NEnkclRUSU6JRWK=
OE33 M3:0NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fw[GlEPTB;ND64PFE3OSEQvF2= MlrxV2FPT0WU
SW982 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XJS2lEPTB;ND65OVA3OSEQvF2= NFP1bIxUSU6JRWK=
A388 MmrqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTVwMEK5PFMh|ryP NIm5d5BUSU6JRWK=
TI-73 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnKTWM2OD13LkC2NVk1KM7:TR?= Ml\WV2FPT0WU
HCT-116 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLpTWM2OD13LkC5PFg6KM7:TR?= NFrh[FFUSU6JRWK=
HuP-T3 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XQZmlEPTB;NT6xPFcxQSEQvF2= NV;GR4ZqW0GQR1XS
G-402 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LZe2lEPTB;NT6xPVQyPiEQvF2= Mo\rV2FPT0WU
NCI-H1792 NVrHPVFsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWi4UWRkUUN3ME21MlI1PjJ{IN88US=> MkXPV2FPT0WU
NCI-H209 NYPOOVkxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\iTWM2OD13LkK1PVQzKM7:TR?= MlvsV2FPT0WU
NCI-H1650 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\NVWlEPTB;NT6zNFY{PCEQvF2= Mnj2V2FPT0WU
LCLC-97TM1 M3jHOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2W5T2lEPTB;NT6zNVgxQCEQvF2= MV;TRW5ITVJ?
S-117 NGfYVHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIi1VJBKSzVyPUWuN|Y6PzZizszN NFHpbZhUSU6JRWK=
GI-ME-N M{njVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXj3cINnUUN3ME21MlM6PjhzIN88US=> MVTTRW5ITVJ?
NCI-H2122 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1iwe2lEPTB;NT60PVM6PyEQvF2= MYLTRW5ITVJ?
NCI-H1793 M1PV[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnBboZ7UUN3ME21MlY4PTl|IN88US=> M4XHXnNCVkeHUh?=
C2BBe1 NXfG[|VIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TiSGlEPTB;NT63NFA5QCEQvF2= MnvJV2FPT0WU
TE-12 M3PCcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zmPGlEPTB;NT64NFU2PiEQvF2= NV\Ge5BJW0GQR1XS
LCLC-103H NVLzdpM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3jOVd2UUN3ME21MlkyPyEQvF2= MXHTRW5ITVJ?
A673 NHWybFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTVwOUG5N|Ih|ryP MYnTRW5ITVJ?
BB30-HNC NH72NYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWO0RWsxUUN3ME21Mlk5OzZizszN M3L4N3NCVkeHUh?=
SF295 M{nlbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTZwMEC0NlIh|ryP M1LCRnNCVkeHUh?=
KU-19-19 M4HBeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXaTWM2OD14LkCxO|MyKM7:TR?= NVPBUYl5W0GQR1XS
CFPAC-1 MmXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkO2TWM2OD14LkC0OFQ{KM7:TR?= MnfEV2FPT0WU
LoVo MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTZwMEWwOlMh|ryP MXrTRW5ITVJ?
8505C M1PWeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHv1VlFKSzVyPU[uNFc2PzNizszN NILBW|hUSU6JRWK=
GMS-10 M1nVWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4[xZWlEPTB;Nj6xOVAxOiEQvF2= NIrv[JJUSU6JRWK=
Ca9-22 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTZwMU[3NUDPxE1? NEPkdIRUSU6JRWK=
DOK M{fNUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\U[mlEPTB;Nj6yNlA4OiEQvF2= MXXTRW5ITVJ?
FADU NH7xUHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTMTWM2OD14LkK2NFM6KM7:TR?= MoCyV2FPT0WU
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CAL-33 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fZfmlEPTB;Nj6yPVIxOSEQvF2= MlvOV2FPT0WU
SHP-77 NWq0SoVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2Lzb2lEPTB;Nj6zNVUyOiEQvF2= NWDjTHZiW0GQR1XS
LXF-289 NI\pbIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1y1d2lEPTB;Nj6zN|Q2PSEQvF2= NFnUSpFUSU6JRWK=
GB-1 M{P5N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnkS49KSzVyPU[uN|gzKM7:TR?= NH\KN3hUSU6JRWK=
KS-1 M{XuVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEW2W|FKSzVyPU[uN|g1PDdizszN M4XwXHNCVkeHUh?=
D-502MG MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrCUpZKSzVyPU[uOFI{PzZizszN Mn;BV2FPT0WU
LAN-6 MnvGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWD4WIk2UUN3ME22MlUyODJ|IN88US=> M2jMXXNCVkeHUh?=
H-EMC-SS NG\ibYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fXW2lEPTB;Nj61OlE1PyEQvF2= Ml74V2FPT0WU
LC-2-ad M{nhU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPHSFlCUUN3ME22MlYxODd4IN88US=> MlT1V2FPT0WU
NCI-H1693 M2XtOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV[xXWpCUUN3ME22MlYzOjF3IN88US=> MkPoV2FPT0WU
SK-N-FI M{KyOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTZwN{WwOFQh|ryP NXL2U|k5W0GQR1XS
D-423MG MlvFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHGwSWRKSzVyPU[uO|YyOTdizszN MUXTRW5ITVJ?
KNS-42 NWHoO2ZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHFZmlKSzVyPU[uO|gyQTdizszN MVzTRW5ITVJ?
GCT MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PEbGlEPTB;Nj65N|gh|ryP M1PaVXNCVkeHUh?=
DSH1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTdwME[zN{DPxE1? M4K1N3NCVkeHUh?=
D-247MG NFzIRY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\DTWM2OD15LkC3PFgyKM7:TR?= MnrSV2FPT0WU
NCI-SNU-5 MnvXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknrTWM2OD15LkG4N|cyKM7:TR?= MmDrV2FPT0WU
TE-6 NXjHT4t4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTdwMkC2NFEh|ryP NHfFR5BUSU6JRWK=
NOMO-1 NV\1UpZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTxXnBKSzVyPUeuNlIyOjdizszN NFrpeFJUSU6JRWK=
NB17 Mk\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvVRXdKSzVyPUeuN|A{ODlizszN NYnme4loW0GQR1XS
EW-22 MkTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfPTWM2OD15LkO0N|Q5KM7:TR?= MmjhV2FPT0WU
EW-13 Mn32S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fRZ2lEPTB;Nz6zOVE3OiEQvF2= MorHV2FPT0WU
DOHH-2 M1r6TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jGTWlEPTB;Nz60OFAzKM7:TR?= MknrV2FPT0WU
TGBC1TKB NFn3RnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvSTWM2OD15LkS5PFk6KM7:TR?= MknPV2FPT0WU
GR-ST MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlSwTWM2OD15LkWyOVk1KM7:TR?= NGDFOWhUSU6JRWK=
KYSE-520 NEDjTHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoT0TWM2OD15LkW1OVE2KM7:TR?= NGPrdIZUSU6JRWK=
CAPAN-1 M2r6OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfENlFSUUN3ME23MlU6PTFizszN NVrLSVNHW0GQR1XS
HCE-4 MmXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXOO4lCUUN3ME23MlYzOjd7IN88US=> NX;LOWF3W0GQR1XS
MLMA NVnQdlluT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3pTWM2OD15Lk[yPVU4KM7:TR?= MWHTRW5ITVJ?
HT-144 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDCTWM2OD15Lk[1N|Y5KM7:TR?= NILBbppUSU6JRWK=
KYSE-180 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXNTWM2OD15LkexNVY6KM7:TR?= NV7LUo5KW0GQR1XS
TE-5 M3HacWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;WTVFmUUN3ME23Mlk2QTdzIN88US=> M1zvfHNCVkeHUh?=
IGROV-1 NFTadFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTdwOUi1OVEh|ryP M4\PeXNCVkeHUh?=
NCI-H1581 NH7tVHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mni1TWM2OD16LkCxNkDPxE1? NUXWUWtGW0GQR1XS
SW1990 MlLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfQTWM2OD16LkC0OlU6KM7:TR?= M3XiU3NCVkeHUh?=
EFM-19 NV\nXGpZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkL5TWM2OD16LkC4OVQ2KM7:TR?= NFLSTHhUSU6JRWK=
OGR-1 M1H3Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRThwNEOwNlMh|ryP NWDBU5A2W0GQR1XS
U-118-MG Mne5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DSOGlEPTB;OD60N|Q3OyEQvF2= M1nMPXNCVkeHUh?=
SK-OV-3 M3nHTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moi3TWM2OD16LkS2O|Y2KM7:TR?= M1jxcXNCVkeHUh?=
KNS-62 M3vYeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRThwNUG3OlEh|ryP MoLPV2FPT0WU
GOTO MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;VPVlKSzVyPUiuOVc3OzVizszN MUXTRW5ITVJ?
8305C NYj1cnNFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDSSJlUUUN3ME24MlcxPDh2IN88US=> MkPtV2FPT0WU
RPMI-2650 M4f5NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\5bIRKSzVyPUiuO|E6PTVizszN NHiz[oZUSU6JRWK=
NEC8 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\ZZXNKSzVyPUiuO|Q{ODdizszN NUH4Oo11W0GQR1XS
KYSE-450 M2\SZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XSb2lEPTB;OD64OlU1QCEQvF2= M{\hfHNCVkeHUh?=
RMG-I MnnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTnTWM2OD17LkG0NFU5KM7:TR?= NIDIdlZUSU6JRWK=
CAKI-1 NGK0d3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTlwM{G5O|kh|ryP M4fmOHNCVkeHUh?=
KYSE-510 M3zoc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTlwM{W3O|gh|ryP MYLTRW5ITVJ?
A4-Fuk NV\Uc3R4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTlwM{[3NFEh|ryP NGHPUHhUSU6JRWK=
AN3-CA M2nGZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTlwNEW0OFQh|ryP M2nWe3NCVkeHUh?=
SK-N-DZ MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTlwN{K4OFkh|ryP MXrTRW5ITVJ?
HSC-2 NIP6cHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnDPHB7UUN3ME25Mlc3PjJ7IN88US=> MkLQV2FPT0WU
EW-1 NHLkNo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{[yXmlEPTB;OT63PVM3QSEQvF2= NEnMRWpUSU6JRWK=
D-566MG NIH1NGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTLO2xtUUN3ME25Mlg{PjZ2IN88US=> MnXBV2FPT0WU
COLO-792 MoHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fjWmlEPTB;OT65PFc1PiEQvF2= MmnpV2FPT0WU
TE-10 MkmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoGzTWM2OD1zMD6wN|k3KM7:TR?= MYnTRW5ITVJ?
NCI-H650 M1nub2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfseI1KSzVyPUGwMlQzQDZizszN NUHXe2ZsW0GQR1XS
U-266 NH\6NZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDIZ2VFUUN3ME2xNE41PTVizszN M{nZOnNCVkeHUh?=
Detroit562 MlfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjzRY1DUUN3ME2xNU4xPTF3IN88US=> NFXtPXpUSU6JRWK=
NH-12 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzsTWM2OD1zMT6xOFQ3KM7:TR?= MVnTRW5ITVJ?
CO-314 M4HEfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\CTWM2OD1zMT6yPFQzKM7:TR?= Mm[yV2FPT0WU
IST-MEL1 NVyw[lZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLUbIQ2UUN3ME2xNU42OzJ|IN88US=> NWXuXppkW0GQR1XS
KNS-81-FD NITXWZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XofmlEPTB;MUGuOVUzPyEQvF2= Ml3rV2FPT0WU
SW1463 NYT3dmJmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH2wNJBKSzVyPUGxMlU6QDlizszN MUTTRW5ITVJ?
NCI-H23 NGXnPY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTFzLk[1OVIh|ryP Mn31V2FPT0WU
SK-MEL-2 NVnHTpdmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTFzLkexPVch|ryP MWjTRW5ITVJ?
NB13 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHEO4FKSzVyPUGyMlE1QTVizszN MWDTRW5ITVJ?
Daoy M2jhbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTF{LkK4OVYh|ryP NIrWV2NUSU6JRWK=
NCI-H1623 NEnH[VhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTF{LkO4NFEh|ryP MVrTRW5ITVJ?
NMC-G1 NXrzeI5tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTF{LkexO{DPxE1? NI\VT2tUSU6JRWK=
DK-MG NVOwcHRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTF{Lkm0PFIh|ryP MlzZV2FPT0WU
TCCSUP MoHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWW4TGIyUUN3ME2xN{4yOjh2IN88US=> MW\TRW5ITVJ?
SCC-15 NVHLbJp[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rSdmlEPTB;MUOuNlY2OSEQvF2= M1rTV3NCVkeHUh?=
NOS-1 NUjtVHlsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWT0d2lEUUN3ME2xN{4zQDl|IN88US=> Ml7TV2FPT0WU
RH-1 MkHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTF|LkOwN|ch|ryP MmT4V2FPT0WU
SK-MEL-3 M{jFW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXi[Xc5UUN3ME2xN{4{PzJ6IN88US=> NFW4OWpUSU6JRWK=
NB5 NHnB[o1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3BTWM2OD1zMz60NFY4KM7:TR?= MnL4V2FPT0WU
SNU-387 M372dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTF|LkWwO|Ih|ryP NXzYd406W0GQR1XS
CAL-120 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfOU5dHUUN3ME2xN{43PzF6IN88US=> MUHTRW5ITVJ?
Mo-T MoHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3RU3JKSzVyPUGzMlcxPyEQvF2= MW\TRW5ITVJ?
LNCaP-Clone-FGC M4S0ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTF|Lke5PVIh|ryP NVfs[3ZZW0GQR1XS
CAN MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfNTWM2OD1zND6wNlg5KM7:TR?= NUCwdHZSW0GQR1XS
SK-MEL-30 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XhOGlEPTB;MUSuNFY{KM7:TR?= MnPOV2FPT0WU
COLO-678 MkWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HJbmlEPTB;MUSuNFgzOiEQvF2= M3zHZXNCVkeHUh?=
SCC-9 MnSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnjU25HUUN3ME2xOE4yODJzIN88US=> MUTTRW5ITVJ?
KINGS-1 M3XE[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTF2LkG0NFIh|ryP NISwVY5USU6JRWK=
SL-513 M3ewSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTF2LkG4O{DPxE1? MljSV2FPT0WU
HLE MlThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nuWmlEPTB;MUSuN|g2OiEQvF2= MV\TRW5ITVJ?
SW1573 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXVenhKSzVyPUG0MlQ1OzVizszN NFHLVXJUSU6JRWK=
KYSE-140 NWCxSZlbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rSNmlEPTB;MUSuOlMzPyEQvF2= M4S3WXNCVkeHUh?=
SK-PN-DW MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfHTFZ6UUN3ME2xOE45ODBzIN88US=> MX3TRW5ITVJ?
A253 NV;uenFvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUL5R3BDUUN3ME2xOU4xPjJ3IN88US=> MWXTRW5ITVJ?
CAL-12T M4PtWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\0U4hjUUN3ME2xOU41PjZ{IN88US=> M1i3O3NCVkeHUh?=
COLO-679 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTF3Lke2PFMh|ryP MkDOV2FPT0WU
UACC-257 MkfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PE[mlEPTB;MU[uNVIxOSEQvF2= Mn7TV2FPT0WU
U-87-MG MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3qyfmlEPTB;MU[uN|UzOyEQvF2= M3LrZXNCVkeHUh?=
HCC1806 NUf2OI5LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorhTWM2OD1zNj63NFcyKM7:TR?= NH7HdGFUSU6JRWK=
NCI-H2170 NUG4UoRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\IfY5IUUN3ME2xO{4zPDR6IN88US=> NF\4RmxUSU6JRWK=
AGS M4GyWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DsVmlEPTB;MUeuN|gxQCEQvF2= M4TSR3NCVkeHUh?=
MEL-HO MnnJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHT6UXVKSzVyPUG3Mlc2ODNizszN MYjTRW5ITVJ?
SW48 MoriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDrZ4NKSzVyPUG3Mlc4OTZizszN MWrTRW5ITVJ?
HuP-T4 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHW4VWlKSzVyPUG4MlAzODZizszN M2LsWHNCVkeHUh?=
NCI-H720 NIDOSVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTF6LkG0NFIh|ryP MXrTRW5ITVJ?
RCC10RGB M{HzXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{X2WGlEPTB;MUiuNVY6PyEQvF2= NVnuR2Y3W0GQR1XS
HD-MY-Z NVH0b4p7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPDTWM2OD1zOD6yNlU1KM7:TR?= MX;TRW5ITVJ?
A427 NVT1Ro1oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moi3TWM2OD1zOD61NFk1KM7:TR?= MnXqV2FPT0WU
HCC2998 NF23O2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTF6Lk[wOVEh|ryP MkXBV2FPT0WU
EPLC-272H NVnHXnp[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTF7LkC0N|Qh|ryP M1HBRnNCVkeHUh?=
C32 MlLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoP0TWM2OD1zOT6wOFUh|ryP NVW0S2R4W0GQR1XS
UMC-11 MnewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TB[mlEPTB;MUmuNlEzOyEQvF2= MorGV2FPT0WU
CaR-1 M2[1bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUGwW5B6UUN3ME2xPU43QDB2IN88US=> NFrEWVVUSU6JRWK=
KYSE-410 Ml7MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTF7LkmxN|kh|ryP NUTtPI9vW0GQR1XS
HuCCT1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;2PWlEPTB;MkCuOlI6PCEQvF2= MmTIV2FPT0WU
LB996-RCC NVzhfHF6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\tSo04UUN3ME2yNE44OTZ6IN88US=> NUHtS2xVW0GQR1XS
KYSE-70 NU\ZcYpGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TkN2lEPTB;MkCuPFA2QSEQvF2= MW\TRW5ITVJ?
CAL-72 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTJyLkmxOUDPxE1? MV7TRW5ITVJ?
Capan-2 NILVSpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkP1TWM2OD1{MT6wOFE{KM7:TR?= MX;TRW5ITVJ?
PANC-08-13 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3hTWM2OD1{MT6yOVE2KM7:TR?= MmSxV2FPT0WU
SBC-1 MlG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTJzLkOwPFEh|ryP NYL1PWhWW0GQR1XS
MFM-223 NF[wdmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4W2SmlEPTB;MkGuN|M1OiEQvF2= MVfTRW5ITVJ?
BB49-HNC NHLjN4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTJzLkW3NVYh|ryP M1HFfHNCVkeHUh?=
SH-4 Mn:zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPDTWM2OD1{MT62OlE5KM7:TR?= NXizWWlnW0GQR1XS
HuO9 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTYUpBKSzVyPUKxMlk5OjVizszN M1\SOHNCVkeHUh?=
AM-38 NWjPOIZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjJTWM2OD1{Mj6wOFg2KM7:TR?= NITsNGdUSU6JRWK=
A431 NX;ZXWlFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorUTWM2OD1{Mz6yNVE6KM7:TR?= NIXBVFJUSU6JRWK=
YAPC NXjFdXR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLhW5VKSzVyPUKzMlI3PTFizszN MYjTRW5ITVJ?
LU-139 NX7I[mhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELnUINKSzVyPUKzMlQ5ODlizszN NHTDWpBUSU6JRWK=
HEC-1 M3L0S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjXTWM2OD1{Mz60PVM4KM7:TR?= MYLTRW5ITVJ?
SCC-25 NGrpSIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHv[oNIUUN3ME2yOE4{ODB4IN88US=> NI\Z[FVUSU6JRWK=
HT-29 NUHoRo5pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TpXmlEPTB;MkSuN|gzOyEQvF2= M33q[XNCVkeHUh?=
PC-14 NYDobHNLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7CTWM2OD1{ND62OVcyKM7:TR?= NH;NPJRUSU6JRWK=
Calu-6 NXrCfpFsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TpdWlEPTB;MkWuOVA4OSEQvF2= MlTSV2FPT0WU
SJRH30 NEW4fJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXP2WFdnUUN3ME2yOU43PDl4IN88US=> M1jVSHNCVkeHUh?=
ChaGo-K-1 M2m3SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M335SmlEPTB;Mk[uNVYzQSEQvF2= MWfTRW5ITVJ?
IA-LM MmjES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYO3cHJQUUN3ME2yOk4{PjR3IN88US=> M3W2[nNCVkeHUh?=
GP5d MkPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTJ4LkS0PVEh|ryP Mo\EV2FPT0WU
NCI-H2291 M3PXW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DzdWlEPTB;Mk[uOlU1OSEQvF2= MmX3V2FPT0WU
BALL-1 M{\y[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTJ4LkmzPVch|ryP MlLDV2FPT0WU
HCC1954 NEnG[GpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTJ4Lkm4NFgh|ryP NV:1Z2FbW0GQR1XS
NCI-H2452 M2PkRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEO5W2RKSzVyPUK3MlQyPjNizszN NYjKT4NzW0GQR1XS
LU-99A MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTJ5LkW1PFIh|ryP NXPuS5N{W0GQR1XS
NTERA-S-cl-D1 NXL2dmh6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M320fmlEPTB;MkeuO|I6QSEQvF2= NF\a[WZUSU6JRWK=
PANC-10-05 NVf1TFNHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTJ5Lke3O|Uh|ryP M{fienNCVkeHUh?=
NCI-H2405 MkPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NESzb2JKSzVyPUK3Mlk{QDdizszN NELjdZpUSU6JRWK=
MDA-MB-415 MnvFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHz0dW9KSzVyPUK4MlQyOzdizszN MV3TRW5ITVJ?
NCI-H2342 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnK2TWM2OD1{OD61NlgyKM7:TR?= M{DwPHNCVkeHUh?=
TGBC24TKB NW[xc5VHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LzNWlEPTB;MkiuO|EyPyEQvF2= NYC4eWNZW0GQR1XS
LU-134-A NWj2[ItrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTJ6LkmyOlEh|ryP Ml\OV2FPT0WU
SCC-4 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTNzLkC0PVQh|ryP MV7TRW5ITVJ?
Saos-2 M1js[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTNzLkmzNFYh|ryP MlHNV2FPT0WU
RERF-LC-MS NIrVeW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;nZmlEPTB;M{KuPFI{OSEQvF2= M3O2VHNCVkeHUh?=
M14 MoHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTN{Lkm3OlQh|ryP NWnhUWp4W0GQR1XS
HPAF-II M{LUO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTN|LkWwNVEh|ryP NEXyWFVUSU6JRWK=
NCI-H1755 NH3pSFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrYW3NwUUN3ME2zOE4{OzB3IN88US=> MYTTRW5ITVJ?
D-392MG NFHRSIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfuTWM2OD1|NT64Olc1KM7:TR?= MWnTRW5ITVJ?
A704 NETPZVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPjTWM2OD1|Nj6wOFI4KM7:TR?= NIHpcnZUSU6JRWK=
CP50-MEL-B M2nQXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HtNWlEPTB;M{[uNVkyOSEQvF2= M4TLNXNCVkeHUh?=
EW-18 M1r0OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzIdFJ7UUN3ME2zOk41PTJizszN MYLTRW5ITVJ?
WM-115 M3rGfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLqTWM2OD1|Nj64NFk6KM7:TR?= MmjlV2FPT0WU
LU-65 M4DXVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLFTWM2OD1|Nz6xOFE4KM7:TR?= MYrTRW5ITVJ?
NCI-H1563 Mm\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTN5LkK0PFQh|ryP NWfYTm5FW0GQR1XS
DBTRG-05MG NGnIcGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTN6LkC2PVEh|ryP MVvTRW5ITVJ?
NCI-H630 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmX0TWM2OD1|OD60O|E1KM7:TR?= NIi5NlFUSU6JRWK=
NCI-H1155 M{[yW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTN7LkK0NkDPxE1? M37yeHNCVkeHUh?=
OVACR-3 NEXkcFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3X4d2lEPTB;M{muPVE6PSEQvF2= NHvxVJlUSU6JRWK=
OAW-42 NVT0TXd3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLiSIp3UUN3ME20NE41OjV6IN88US=> NH\rNI5USU6JRWK=
JVM-2 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjrV4FzUUN3ME20NU4zPDF3IN88US=> Ml\MV2FPT0WU
C3A MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LJdmlEPTB;NEGuN|Q1PyEQvF2= MnXsV2FPT0WU
HT55 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfIbFloUUN3ME20Nk4zQDRzIN88US=> NWeyd24zW0GQR1XS
OVCAR-4 NVHEPY1uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;pS4g{UUN3ME20Nk4zQTd2IN88US=> NXrx[G1jW0GQR1XS
MEG-01 NXPLc5FUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYn4OXJ6UUN3ME20Nk41PjF4IN88US=> NHruSVdUSU6JRWK=
NCI-H82 NV;YSohrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTR|Lkm4PVIh|ryP NVLYUZFsW0GQR1XS
JEG-3 NX;pVnE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknITWM2OD12ND65OFch|ryP MWnTRW5ITVJ?
BPH-1 NG\nSoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTR4LkO5PVgh|ryP M1jNXnNCVkeHUh?=
MPP-89 NF;6OVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3WPFZPUUN3ME20O{4zQDl6IN88US=> NV35SIRXW0GQR1XS
ALL-PO NFi1PGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfROlFKSzVyPUS3MlQyQDhizszN MXTTRW5ITVJ?
HT NHTYeJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkexTWM2OD12Nz60PVIh|ryP NHvneGxUSU6JRWK=
NCI-H2347 NEDSVIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmH5TWM2OD12OD6wO|E2KM7:TR?= M2jvRXNCVkeHUh?=
A2780 Mk\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWGwN4FOUUN3ME20PU41OjJ6IN88US=> M2jBW3NCVkeHUh?=
KARPAS-299 NID6WWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3iZoFKSzVyPUS5MlUyOTlizszN M{HnRXNCVkeHUh?=
NCI-H1651 M3f3WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPkVGo6UUN3ME20PU45QDJzIN88US=> MWrTRW5ITVJ?

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
RB1 (pT821) / RB1 (pS780) / RB1 / CDK6 / CCND2 / RUNX1 / ETO; 

PubMed: 30300583     


Immunoblots showing dose-dependent impact of 72 hr palbociclib treatment on indicated protein levels in Kasumi-1 and SKNO-1 cells.

pRb(S807, 811) / CDK4 / CDK6 / PARP; 

PubMed: 28453226     


Effects of palbociclib on CDK4/6-Rb pathway. HCC cells were treated with different doses of palbociclib for 24 h, and then, the cells were subjected to western blot analysis. CF, cleaved fragment. 

LC3-I / LC3-II; 

PubMed: 28453226     


Palbociclib increases LC3-II amount in a dose-dependent manner in HCC cell lines. 

pAMPKα(T172) / pULK1(S317); 

PubMed: 28453226     


Dose-dependent response of palbociclib on AMPK-related molecules. HCC cells were treated with different concentrations of palbociclib for 24 h. The phosphorylation of the indicated proteins was determined by western blotting. 

SMAD2 (pS255); 

PubMed: 30343527     


T47D cells were treated with indicated concentrations of palbociclib for 24 h to evaluate substrate phosphorylation.

30300583 28453226 30343527
Growth inhibition assay
Cell viability; 

PubMed: 29670090     


Cell viability was determined by MTT assays after palbociclib exposure for 2, 4, and 6 days. The cell cycle of SYO-1 and Fuji cells was assessed after exposure to palbociclib (1 µM) for 24 h by flow cytometry analysis.

29670090
Immunofluorescence
SAHF/ATRX; 

PubMed: 26988987     


DAPI staining for senescence-associated heterochromatic foci (SAHF, left panel) and ATRX staining (right panel) in 1205Lu cells +/− palbociclib for 8 days. 

LC3B; 

PubMed: 28453226     


LC3B immunofluorescence in palbociclib‐treated Hep3B cells. Arrowheads indicate LC3-positive autophagosomes. Nuclei were counterstained with DAPI (blue).

26988987 28453226
ELISA
PGE2; 

PubMed: 26540629     


The supernatant of control and 7.5 μM palbociclib-treated cells was collected and stored at −80°C. PGE2 secretion was detected using ELISA.

26540629
体内研究 150 mg/kg PD 0332991处理 MDA-MB-435移植瘤完全抑制肿瘤。在多种人类肿瘤移植瘤中,PD 0332991也显示广谱抗癌活性,通过除去血管中p-Rb和增殖Marker Ki-67,且调节基因使其处于E2F转录水平控制。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

- 合并

Cdk实验:

PD0332991溶解在DMSO中。在96孔板上进行CDK 实验。通过杆状病毒感染,所有的CDK-cyclin 激酶复合体 在昆虫细胞中表达。实验底物为与GST融合的一段pRb。每孔体积为0.1 ml,包含:终浓度为20 mm Tris-HCl(pH 为7.4), 50 mmNaCl, 1 mm二硫苏糖醇, 10 mmMgCl2, 25 μm ATP (用于CDK4-cyclin D1, CDK6-cyclin D2,和CDK6-cyclin D3)或12 μm ATP (用于CDK2-cyclin E, CDK2-cyclin A, 和CDC2-cyclin B),0.25 μCi [γ-32P]ATP, 20 ng 酶, 1 μg GST·RB-Cterm, 及PD 0332991 (0.001-0.1μM)。除了[γ-32P]ATP的所有混合物加到孔中,放在搅拌器上搅拌2分钟。加入 [γ-32P]ATP开始反应, 在25 oC下温育15分钟。加入0.1 ml 20% 三氯乙酸终止反应, 在4 oC维持至少1小时,使底物沉淀。用0.2 ml 10%三氯乙酸冲洗5次,用β-计数器板测定掺入的放射性。
细胞实验:

[1]

- 合并
  • Cell lines: MDA-MB-435, ZR-75-1, T-47D, MCF-7, H1299, Colo-205, MDA-MB-468, H2009, CRRF-CEM,和K562细胞
  • Concentrations: 0.01-1 μM
  • Incubation Time: 24小时
  • Method:

    肿瘤细胞包括MDA-MB-435, ZR-75-1, T-47D, MCF-7, H1299, Colo-205, MDA-MB-468, H2009, CRRF-CEM,及K562按每孔2×104个细胞接种在96孔板上,温育过夜。加入PD 0332991 (0.01-1 μM) ,37oC温育24小时。每孔加入[14C]胸甘(0.1 μCi) ,进行同位素示踪,持续72小时。用β-计数器板测定掺入的放射性。


    (Only for Reference)
动物实验:

[1]

- 合并
  • Animal Models: 携带晚期人类肿瘤移植瘤,包括结肠-205, MDA-MB-435 乳腺癌, SF-295 恶性胶质瘤, ZR-75-1 乳腺癌, PC-3 前列腺癌, H125 肺癌, SW-620结肠癌, H23肺癌,及MDA-MB-468 乳腺癌 (Rb 阴性)的SCID鼠
  • Dosages: 0-150 mg/kg
  • Administration: 口服饲喂
    (Only for Reference)

溶解度 (25°C)

体外 Water 30 mg/mL (61.98 mM)
DMSO 3 mg/mL warmed (6.19 mM)
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
Saline
6 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 483.99
化学式

C24H29N7O2.HCl

CAS号 827022-32-2
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04483505 Not yet recruiting Drug: Combination Rogaratinib + palbociclib + fulvestrant Breast Cancer Metastatic|Hormone Receptor Positive Malignant Neoplasm of Breast Fundacion CRIS de Investigación para Vencer el Cáncer|Bayer|Pfizer|Apices Soluciones S.L. October 1 2020 Phase 1
NCT04360941 Recruiting Drug: Palbociclib|Drug: Avelumab Triple Negative Breast Cancer|Locally Advanced Breast Cancer|Recurrent Breast Cancer|Metastatic Breast Cancer|ER+ Breast Cancer|HER2-positive Breast Cancer Royal Marsden NHS Foundation Trust|Pfizer|Breast Cancer Now August 11 2020 Phase 1
NCT03870919 Suspended Drug: Palbociclib|Other: locoregional treatment Breast Cancer Stage IV|Radiotherapy|Surgery UNICANCER|Pfizer October 23 2019 Not Applicable

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID