Roscovitine (CYC202)

目录号:S1153 别名: Seliciclib, R-roscovitine

仅限科研使用

Roscovitine (CYC202, Seliciclib, R-roscovitine)是一种有效的,选择性CDK抑制剂,作用于Cdc2CDK2CDK5时,无细胞试验中IC50分别为0.65 μM,0.7 μM和0.16 μM,对CDK4/6几乎没有作用。Phase 2。

Roscovitine (CYC202) Chemical Structure

CAS: 186692-46-6

规格 价格 库存 购买数量
10mM (1mL in DMSO) RMB 1573.18 现货
RMB 1212.83 现货
RMB 3829.77 现货
RMB 7938.98 现货
大包装 有超大折扣

今日订购,明日送达 全国免运费 分装免费 分装成小规格产品(单支最小为1mg)
如1支10mg产品可分装为10支1mg产品

全国免费电话:400-668-6834   |   Email:info@selleck.cn

客户使用Selleck生产的Roscovitine (CYC202)发表文献105篇:

产品安全说明书

CDK抑制剂选择性比较

相关CDK产品

生物活性

产品描述 Roscovitine (CYC202, Seliciclib, R-roscovitine)是一种有效的,选择性CDK抑制剂,作用于Cdc2CDK2CDK5时,无细胞试验中IC50分别为0.65 μM,0.7 μM和0.16 μM,对CDK4/6几乎没有作用。Phase 2。
靶点
CDK5/p35 [1]
(Cell-free assay)
Cdc2/CyclinB [1]
(Cell-free assay)
CDK2/CyclinA [1]
(Cell-free assay)
CDK2/CyclinE [1]
(Cell-free assay)
ERK2 [1]
(Cell-free assay)
0.16 μM 0.65 μM 0.7 μM 0.7 μM 14 μM
体外研究

Roscovitine作用于细胞周期蛋白依赖性激酶具有高效性和高度选择性,作用于cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E和cdk5/p53时IC50分别为0.65,0.7,0.7和0.16 μM。纳摩尔级Roscovitine作用于海星卵母细胞和海胆胚胎,可逆抑制在前中期间转变, 在体外作用于非洲爪蟾卵提取物,抑制M期促进因子活性和体外DNA合成,且抑制哺乳动物细胞系增殖,IC50为16 μM。[1] 浓度为7.5, 12.5和 25 mM的 Roscovitine作用于肾小球系膜细胞,导致CDK2活性分别降低25,50% 和100%,这种作用存在剂量依赖性。[2] 最新研究显示Roscovitine作用于盘基网柄菌,抑制cdk5激酶活性,细胞增殖,多细胞发展,和cdk5核转运, 不会影响cdk5蛋白表达。[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
LB771-HNC M2PqW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnkc2RmUUN3ME20PE46OjF{IN88US=> NEiwTJM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyPDd4Mj:nQnNCVkeHUkyvZV4>
LB2241-RCC M3fGPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTR6Lk[yNFIh|ryP NGCz[pU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyPDd4Mj:nQnNCVkeHUkyvZV4>
DU-4475 NIrJbmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTR6LkS5N|ch|ryP NXKwemFPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTR5NkKvK|5USU6JRWK8M4E,
LB2518-MEL NWfRPJViT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTR5LkC0OFgh|ryP M2\lPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE1PzZ{Lze+V2FPT0WUPD;hQi=>
NCI-H209 Ml33S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTR4LkCxNVUh|ryP M4DNRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE1PzZ{Lze+V2FPT0WUPD;hQi=>
CGTH-W-1 M2rVfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTR2Lkm2PVch|ryP NV60XnFiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTR5NkKvK|5USU6JRWK8M4E,
MS-1 M3G0Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFP5PJJKSzVyPUSyMlg6OyEQvF2= NEHVTmc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyPDd4Mj:nQnNCVkeHUkyvZV4>
GI-ME-N MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTR{Lk[2O|Eh|ryP NXLhWYNWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTR5NkKvK|5USU6JRWK8M4E,
DG-75 NIjoVJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTR{Lk[1OFYh|ryP M1fhdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE1PzZ{Lze+V2FPT0WUPD;hQi=>
MLMA MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DxcWlEPTB;NEKuNlc5PyEQvF2= MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxOFc3Oi9pPmPBUmdGWjxxYU6=
HT MljSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUS0NY1DUUN3ME20Nk4xODJ6IN88US=> NYq5XpFPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTR5NkKvK|5USU6JRWK8M4E,
LC-1F MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTRzLkW3NFUh|ryP NH7tNZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyPDd4Mj:nQnNCVkeHUkyvZV4>
NCI-H1882 NYTyW4xFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTRyLkW5PVgh|ryP MnzGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVQ4PjJxJ{7TRW5ITVJ:L3G+
NTERA-S-cl-D1 NXO2ToFDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXwdpVKSzVyPUO5MlU5PDJizszN M4G2fFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE1PzZ{Lze+V2FPT0WUPD;hQi=>
NCI-H345 NHLHW|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XMT2lEPTB;M{iuPVExPiEQvF2= NIOwU449[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyPDd4Mj:nQnNCVkeHUkyvZV4>
MONO-MAC-6 NYm4N|U1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TObmlEPTB;M{iuNlQ4PyEQvF2= MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxOFc3Oi9pPmPBUmdGWjxxYU6=
RS4-11 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jwWmlEPTB;M{euO|A3QSEQvF2= NELy[JA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyPDd4Mj:nQnNCVkeHUkyvZV4>
ML-2 M3;FTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTN5Lk[3NVIh|ryP NHTve|M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyPDd4Mj:nQnNCVkeHUkyvZV4>
OPM-2 MlXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPKNld4UUN3ME2zO{4zQTR7IN88US=> M3TrcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE1PzZ{Lze+V2FPT0WUPD;hQi=>
LU-139 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\qZoZKSzVyPUO3MlE5PTZizszN M2PLTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE1PzZ{Lze+V2FPT0WUPD;hQi=>
COLO-684 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTN5LkCxNkDPxE1? NF;DSmg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyPDd4Mj:nQnNCVkeHUkyvZV4>
MOLT-4 NYDUeWFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnGem9UUUN3ME2zOk4{Ojd4IN88US=> NEj5VGM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyPDd4Mj:nQnNCVkeHUkyvZV4>
TE-6 NVHBcmZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXyWmJKSzVyPUO2MlMzPDZizszN MlLRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVQ4PjJxJ{7TRW5ITVJ:L3G+
TE-441-T NFrKV2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHr4VGdKSzVyPUO2MlEyPDhizszN NGjEbIs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyPDd4Mj:nQnNCVkeHUkyvZV4>
IMR-5 NV\RWWh{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zv[mlEPTB;M{WuN|E{QSEQvF2= NX\6N3dxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTR5NkKvK|5USU6JRWK8M4E,
K5 MoHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHnTWM2OD1|NT6wPFYyKM7:TR?= MlrFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVQ4PjJxJ{7TRW5ITVJ:L3G+
TE-10 NInOOpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTN2Lkm0NlIh|ryP NHHSdWw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyPDd4Mj:nQnNCVkeHUkyvZV4>
NCI-H2141 M1z3eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPxTWM2OD1|ND62OVM{KM7:TR?= NGC5SIU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyPDd4Mj:nQnNCVkeHUkyvZV4>
KGN MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rHSWlEPTB;M{SuNlUzPCEQvF2= MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxOFc3Oi9pPmPBUmdGWjxxYU6=
LP-1 NXTXeYRiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\XTVdKUUN3ME2zN{45QTB6IN88US=> NIfmb3k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyPDd4Mj:nQnNCVkeHUkyvZV4>
NCI-H64 M2\ldmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvZR5hKSzVyPUOzMlg2QTdizszN NYOxT4NjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTR5NkKvK|5USU6JRWK8M4E,
RKO MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYf6[GdOUUN3ME2zN{42QTZ7IN88US=> MmD5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVQ4PjJxJ{7TRW5ITVJ:L3G+
NCI-H526 M{mydWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDQVG9KSzVyPUOzMlQ6OzZizszN M1nXOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE1PzZ{Lze+V2FPT0WUPD;hQi=>
GOTO NI[5XoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jXPGlEPTB;M{KuPVEzQSEQvF2= M3\UNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE1PzZ{Lze+V2FPT0WUPD;hQi=>
Calu-6 NInFNlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTN{LkS3OFUh|ryP NIrPZ4s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyPDd4Mj:nQnNCVkeHUkyvZV4>
LOUCY M{[yTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfsV4tDUUN3ME2zNk4yOjV|IN88US=> MkHlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVQ4PjJxJ{7TRW5ITVJ:L3G+
SK-N-FI Ml;US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHl[3ZKSzVyPUOxMlc2OzVizszN NHnIdnI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyPDd4Mj:nQnNCVkeHUkyvZV4>
SIG-M5 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofuTWM2OD1|MT62PFM{KM7:TR?= M{\OdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE1PzZ{Lze+V2FPT0WUPD;hQi=>
NKM-1 NFf6U2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTNzLkGzPVch|ryP M1jXOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE1PzZ{Lze+V2FPT0WUPD;hQi=>
NCI-SNU-1 NXPYfXA3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTNzLkGwOVkh|ryP MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxOFc3Oi9pPmPBUmdGWjxxYU6=
NCI-H82 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fZfGlEPTB;M{GuNFE{PSEQvF2= MlPzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVQ4PjJxJ{7TRW5ITVJ:L3G+
NCI-H510A MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TDRWlEPTB;M{CuNFMzQSEQvF2= NEDBWWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyPDd4Mj:nQnNCVkeHUkyvZV4>
ES3 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnKZYxPUUN3ME2yPU46PTh{IN88US=> MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxOFc3Oi9pPmPBUmdGWjxxYU6=
BB30-HNC M3nT[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETIS25KSzVyPUK5Mlk1QDNizszN MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxOFc3Oi9pPmPBUmdGWjxxYU6=
KM12 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorsTWM2OD1{OT62NlM6KM7:TR?= NXv0eZl[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTR5NkKvK|5USU6JRWK8M4E,
GI-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfqTWM2OD1{OT6wNVE{KM7:TR?= MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxOFc3Oi9pPmPBUmdGWjxxYU6=
NOS-1 NUfycVBNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHvTWM2OD1{OD65O|M{KM7:TR?= NEH5d5E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyPDd4Mj:nQnNCVkeHUkyvZV4>
TE-8 M1iySWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPJT2tKUUN3ME2yPE46ODhizszN NXXvc4dRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTR5NkKvK|5USU6JRWK8M4E,
TE-9 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjMdYpKSzVyPUK4Mlc6PjlizszN M1v4fFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE1PzZ{Lze+V2FPT0WUPD;hQi=>
HL-60 M2qxOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXj3bZJxUUN3ME2yO{46QDZ7IN88US=> NWDsW3FRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTR5NkKvK|5USU6JRWK8M4E,
QIMR-WIL NGP3d4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjWN|FQUUN3ME2yO{46OTR2IN88US=> MnruQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVQ4PjJxJ{7TRW5ITVJ:L3G+
KARPAS-299 Ml33S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTJ4Lki2OFYh|ryP NUGyfVR7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTR5NkKvK|5USU6JRWK8M4E,
KURAMOCHI NHTheHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHYTWM2OD1{Nj64NFgzKM7:TR?= NV\6eWRxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTR5NkKvK|5USU6JRWK8M4E,
BL-41 MlnDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTJ3Lkm1PVch|ryP MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxOFc3Oi9pPmPBUmdGWjxxYU6=
NCI-H2126 MlXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXKS4pDUUN3ME2yOU43PTJ7IN88US=> MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxOFc3Oi9pPmPBUmdGWjxxYU6=
HOP-62 NFj0XHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXv[ldKSzVyPUK1MlQ1OjVizszN MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxOFc3Oi9pPmPBUmdGWjxxYU6=
IST-SL2 M4TJSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTJ2LkWzOFMh|ryP MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxOFc3Oi9pPmPBUmdGWjxxYU6=
HH Mni2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7YOIV1UUN3ME2yOE4{QDF7IN88US=> MoruQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVQ4PjJxJ{7TRW5ITVJ:L3G+
LS-513 NFe0VHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DYO2lEPTB;MkOuOVE4QSEQvF2= NGXWbIo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyPDd4Mj:nQnNCVkeHUkyvZV4>
EB-3 NH7KOmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTJ|LkG4N|Eh|ryP NIPYVm49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyPDd4Mj:nQnNCVkeHUkyvZV4>
ACN M1vGRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrqToJKSzVyPUKxMlM{QDlizszN M4HMN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE1PzZ{Lze+V2FPT0WUPD;hQi=>
NOMO-1 M{mxWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXW2SldpUUN3ME2yNU4zODB6IN88US=> M1XVN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE1PzZ{Lze+V2FPT0WUPD;hQi=>
ES8 Ml3tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PjVWlEPTB;MkGuNFYh|ryP MnvQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVQ4PjJxJ{7TRW5ITVJ:L3G+
CESS MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTJyLki1OFkh|ryP MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxOFc3Oi9pPmPBUmdGWjxxYU6=
BL-70 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTJyLkOyO|Qh|ryP NEPDS4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyPDd4Mj:nQnNCVkeHUkyvZV4>
MHH-PREB-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jPOGlEPTB;MkCuNFM2PiEQvF2= M2e0dlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE1PzZ{Lze+V2FPT0WUPD;hQi=>
BC-1 MnXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTF7LkGxPVgh|ryP NEjr[o49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyPDd4Mj:nQnNCVkeHUkyvZV4>
LC4-1 NIriRWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPYTWM2OD1zOD64O|M1KM7:TR?= NFvHV2E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyPDd4Mj:nQnNCVkeHUkyvZV4>
COLO-320-HSR MkLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTF6Lke2PFgh|ryP MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxOFc3Oi9pPmPBUmdGWjxxYU6=
A101D M4Pu[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjYTWM2OD1zOD6zNlA5KM7:TR?= M1nIblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE1PzZ{Lze+V2FPT0WUPD;hQi=>
BC-3 MmnMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1q3XWlEPTB;MUiuNFMxPSEQvF2= NEOx[Wc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyPDd4Mj:nQnNCVkeHUkyvZV4>
TGW MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTF5LkixNlQh|ryP NYTndZZvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTR5NkKvK|5USU6JRWK8M4E,
JAR NWm4dmFLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTF5LkCxOVIh|ryP M1vsU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE1PzZ{Lze+V2FPT0WUPD;hQi=>
HD-MY-Z MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHPU2NKSzVyPUG2MlgzPDZizszN NWi1TYIxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTR5NkKvK|5USU6JRWK8M4E,
NCI-H1304 MoDrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmn3TWM2OD1zNj6zOlAyKM7:TR?= NHr2OlI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyPDd4Mj:nQnNCVkeHUkyvZV4>
OS-RC-2 M2e3PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3FSmhKSzVyPUG1Mlg{QDJizszN MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxOFc3Oi9pPmPBUmdGWjxxYU6=
OCI-AML2 M{DmRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTF3Lk[0PFIh|ryP M3:zcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE1PzZ{Lze+V2FPT0WUPD;hQi=>
HCC1599 NF\2flhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DhOGlEPTB;MUSuOVk4PSEQvF2= NFXGWGQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyPDd4Mj:nQnNCVkeHUkyvZV4>
SCC-3 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXFN5NKSzVyPUG0MlI6PTZizszN MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxOFc3Oi9pPmPBUmdGWjxxYU6=
RPMI-6666 M4LFd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXr[mxVUUN3ME2xN{46OTJzIN88US=> NEXhRXc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyPDd4Mj:nQnNCVkeHUkyvZV4>
MEG-01 NITvcGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LZT2lEPTB;MUOuPFM4QSEQvF2= MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxOFc3Oi9pPmPBUmdGWjxxYU6=
Raji NW\WOZJiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTF|Lke4PVQh|ryP MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxOFc3Oi9pPmPBUmdGWjxxYU6=
RPMI-8402 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4C4d2lEPTB;MUOuOlI3OiEQvF2= M1H6dlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE1PzZ{Lze+V2FPT0WUPD;hQi=>
GCIY NWe3c4NyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnQTWV5UUN3ME2xNk45PjF|IN88US=> MmDNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVQ4PjJxJ{7TRW5ITVJ:L3G+
697 M1XvdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrlb4YxUUN3ME2xNk43ODB5IN88US=> M3\OelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE1PzZ{Lze+V2FPT0WUPD;hQi=>
D-247MG MlHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TQbGlEPTB;MUKuN|UyPiEQvF2= M1W4WlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE1PzZ{Lze+V2FPT0WUPD;hQi=>
NB1 M4nXd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDWTWM2OD1zMj6zN|A5KM7:TR?= M3eyVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE1PzZ{Lze+V2FPT0WUPD;hQi=>
COR-L279 M3Hlfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTF{LkK5NFch|ryP MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxOFc3Oi9pPmPBUmdGWjxxYU6=
LB831-BLC M3HXd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHj0fIVKSzVyPUGxMlU3OjRizszN NVf0eHpiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTR5NkKvK|5USU6JRWK8M4E,
ST486 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTFyLkO1NUDPxE1? NVm2TW1URGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTR5NkKvK|5USU6JRWK8M4E,
SK-UT-1 NYDLO5lrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmj0TWM2OD1zMD6zOUDPxE1? MmXLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVQ4PjJxJ{7TRW5ITVJ:L3G+
BB65-RCC NG\lVGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH:4PJlKSzVyPUmuPVc1QTVizszN MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxOFc3Oi9pPmPBUmdGWjxxYU6=
KARPAS-422 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTlwOU[zN|Yh|ryP Mn74QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVQ4PjJxJ{7TRW5ITVJ:L3G+
Becker M3nQdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFz1d21KSzVyPUmuOFYxQDJizszN NYfzd4JSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTR5NkKvK|5USU6JRWK8M4E,
KS-1 NUPzXWU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljLTWM2OD17LkS1O|g2KM7:TR?= NX\nVYFQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTR5NkKvK|5USU6JRWK8M4E,
JiyoyeP-2003 NHvT[5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDDT2V5UUN3ME24MlUxOjZ2IN88US=> M4DCblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE1PzZ{Lze+V2FPT0WUPD;hQi=>
NCCIT MkXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3:wOWlEPTB;Nz61OVQ5OiEQvF2= MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxOFc3Oi9pPmPBUmdGWjxxYU6=
MRK-nu-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPtSIJKSzVyPUeuNVI6PjlizszN NF[5RWQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyPDd4Mj:nQnNCVkeHUkyvZV4>
A3-KAW MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjWZmJQUUN3ME21Mlc3OTF4IN88US=> MnuyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVQ4PjJxJ{7TRW5ITVJ:L3G+
SK-N-MC MkX4dWhVWyCjc4PhfS=> Mm[5dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKFONLV6tUWMh[2WubIO= NIL2UWw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUm1PFU5QSd-MUW5OVg2QDl:L3G+
LP-1 MXzBdI9xfG:|aYOgZZN{[Xl? MlS4N|AhfU1? NWHFPGQ6OyCqcoO= M3m5[Glv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iTGCtNUBk\WyuczDheEA{OCC3TTDh[pRmeiB|IHjyd{B2e2mwZzDUWW5GVCC|dHHpcolv\yCkeTDmcI94KGO7dH;t[ZRzgQ>? NHjJV3U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUm1PFU5QSd-MUW5OVg2QDl:L3G+
LP-1 NYPKRnpHS3m2b4TvfIlkcXS7IHHzd4F6 M2D6WlIxKHSxIEOwJJVO MUGyOEBpenN? Ml6yR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUHAuOSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25ib3[gZ4VtdCC4aXHibYxqfHliYYSgNlAhfG9iM{CgeW0hfHKnYYTl[EBnd3JiMkSgbJJ{KG[xbHzve4VlKGK7IIfhd4hwfXRibXXhd5Vz\WRiYX\0[ZIhfG:2YXygO|IhcHK|IHfyc5d1cCCyZYLpc4Qh[WyjbXHyJIJtfWViYYPzZZkhemWuYYTpeoUhfG9iY3;ueJJwdA>? NYTIRWh7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW5OVg2QDlpPkG1PVU5PTh7PD;hQi=>
LP-1 M2HmUGFxd3C2b4Ppd{Bie3OjeR?= MX2zNEB2VQ>? M4PoWFEvPSCqcoO= MYHJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKEySLUGgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKFKQQTDwc4x6dWW{YYPlJFIheGixc4Doc5NmemmwZTCyJIxmfmWuIHH0JFMxKHWPIHHmeIVzKDFwNTDodpMh[nliaX3teY5w[myxdITpcoc> NIq3WZU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUm1PFU5QSd-MUW5OVg2QDl:L3G+
LP-1 M{\0TWFxd3C2b4Ppd{Bie3OjeR?= MkPmN|AhfU1? NFPYTZA{KGi{cx?= Mn7XTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCOUD2xJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iCPY3ytNUBxem:2ZXnuJIxmfmWuIHH0JFMxKHWPIHHmeIVzKDNiaILzJIJ6KGmvbYXuc4Jtd3S2aX7n MmfOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV7NUi1PFkoRjF3OUW4OVg6RC:jPh?=
LP-1 NH;0ZY9CeG:ydH;zbZMh[XO|YYm= MXyzNEB2VQ>? M1ToblMhfG9iNTDodpM> MmLNTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCOUD2xJINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGyndnXsJI9nKGOuZXH2[YQhWEGUUDDheEA{OCC3TTDh[pRmeiB|IITvJFUhcHK|IHL5JIludXWwb3Lsc5R1cW6p NITzNWs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUm1PFU5QSd-MUW5OVg2QDl:L3G+
NCI-H929 MXXBdI9xfG:|aYOgZZN{[Xl? NUi2[Vg6OzBidV2= MnixOUBpenN? NVzpWlVmUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDOR2kuUDl{OTDj[YxteyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBt\X[nbDDv[kBkdGWjdnXkJHBCWlBiYYSgN|AhfU1iYX\0[ZIhPSCqcoOgZpkhcW2vdX7vZoxwfHSrbne= M1S0NlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3OUW4OVg6Lz5zNUm1PFU5QTxxYU6=
NCI-H929 NXL3fIE6SXCxcITvd4l{KGG|c3H5 NEG2WYU{OCC3TR?= Mlz0NU42KGi{cx?= MWHJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKE6FST3IPVI6KGOnbHzzJIF{e2W|c3XkJIF{KG[jc4Sgd4xwfyCvaXfyZZRqdmdiaInw[ZJxcG:|cHjvdplt[XSnZDDSUmEheG:ueX3ldoF{\SB{TzDmc5JuKGG2IEOwJJVOKGGodHXyJFEvPSCqcoOgZpkhcW2vdX7vZoxwfHSrbne= M1PETFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3OUW4OVg6Lz5zNUm1PFU5QTxxYU6=
RPM18226 MkTMRZBweHSxc3nzJIF{e2G7 M{DzcFMxKHWP Mkf6NU42KGi{cx?= NFfmTZhKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJIh2dWGwIGLQUVE5OjJ4IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDv[kBTVkFicH;sfY1memG|ZTCyJJBpd3OyaH;z[ZJqdmViMjDs[ZZmdCCjdDCzNEB2VSCjZoTldkAyNjViaILzJIJ6KGmvbYXuc4Jtd3S2aX7n NG\KXG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUm1PFU5QSd-MUW5OVg2QDl:L3G+
RPM18226 M4HSTmFxd3C2b4Ppd{Bie3OjeR?= Mlj3N|AhfU1? M3zx[|MhcHK| NX\TeYhuUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDSVG0yQDJ{NjDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4YhVWOuLUGgdJJwfGWrbjDs[ZZmdCCjdDCzNEB2VSCjZoTldkA{KGi{czDifUBqdW23bn;icI91fGmwZx?= NF\rS2Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUm1PFU5QSd-MUW5OVg2QDl:L3G+
RPM18226 NGXre21CeG:ydH;zbZMh[XO|YYm= M1fIcVMxKHWP NU\Fbm5SOyC2bzC1JIhzew>? MXfJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKFKSTUG4NlI3KGOnbHzzJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHzleoVtKG:oIHPs[YF3\WRiUFHSVEBifCB|MDD1UUBi\nSncjCzJJRwKDViaILzJIJ6KGmvbYXuc4Jtd3S2aX7n NGLXZ3U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUm1PFU5QSd-MUW5OVg2QDl:L3G+
NCI-H929 NXjoeWFjSXCxcITvd4l{KGG|c3H5 MYWzNEB2VQ>? M3LmSlMhcHK| MWnJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKE6FST3IPVI6KGOnbHzzJIF{e2W|c3XkJIF{KGOqYX7n[ZMhcW5iWFnBVEBxem:2ZXnuJIxmfmWuIHH0JFMxKHWPIHHmeIVzKDNiaILzJIJ6KGmvbYXuc4Jtd3S2aX7n NUfhZldbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW5OVg2QDlpPkG1PVU5PTh7PD;hQi=>
NCI-H929 M{TicWFxd3C2b4Ppd{Bie3OjeR?= NUXJd2J1OzBidV2= M1HC[VMhcHK| NGDaPYpKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJIh2dWGwIF7DTU1JQTJ7IHPlcIx{KGG|c3Xzd4VlKGG|IHPoZY5o\XNiaX6gd5Vzfmm4aX6gdJJwfGWrbjDs[ZZmdCCjdDCzNEB2VSCjZoTldkA{KGi{czDifUBqdW23bn;icI91fGmwZx?= NWS0bXo6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW5OVg2QDlpPkG1PVU5PTh7PD;hQi=>
RPM18226 NUj6[lFxSXCxcITvd4l{KGG|c3H5 NFPjVYs{OCC3TR?= MX:zJIhzew>? M1;Vc2lv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iUmDNNVgzOjZiY3XscJMh[XRiM{CgeW0h[W[2ZYKgN{BpenNidYPpcochXFWQRVygd5RicW6rbnegZpkh\myxdzDjfZRwdWW2com= MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTl3OEW4PUc,OTV7NUi1PFk9N2F-
NCI-H929 MXfBdI9xfG:|aYOgZZN{[Xl? M13UelMxKHWP NFzP[GMyNjViaILz M2DvTmlv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iTlPJMWg6OjliY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIH;mJHJPSSCyb3z5cYVz[XOnIEKgdIhwe3Cqb4Pldolv\SB{IHzleoVtKGG2IEOwJJVOKGGodHXyJFEvPSCqcoOgZpkhcW2vdX7vZoxwfHSrbne= MkLsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV7NUi1PFkoRjF3OUW4OVg6RC:jPh?=
NCI-H929 NF3N[3RCeG:ydH;zbZMh[XO|YYm= MmjDN|AhfU1? MoLkNU42KGi{cx?= M1n6TWlv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iTlPJMWg6OjliY3XscJMh[XO|ZYPz[YQh[XNiZHXwbI9{eGixconsZZRqd25ib3[gdHJjKGG2IGOyOFkwXDJ3MjDheEA{OCC3TTDh[pRmeiBzLkWgbJJ{KGK7IHntcZVvd2Kub4T0bY5o NXTDW2xlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW5OVg2QDlpPkG1PVU5PTh7PD;hQi=>
NCI-H929 MlT2R5l1d3SxeHnjbZR6KGG|c3H5 NIXtcm0zOCC2bzCzNEB2VQ>? NYnr[m0yOTZiaILz M1vre2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5EUS2KOUK5JINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iClZXzsJJZq[WKrbHn0fUBifCB{MDD0c{A{OCC3TTD0doVifGWmIH\vdkAyPiCqcoOg[o9tdG:5ZXSgZpkhf2G|aH;1eEBu\WG|dYLl[EBi\nSncjD0c5RidCB5MjDodpMh\3Kxd4ToJJBmemmxZDDhcIFu[XJiYnz1[UBie3OjeTDy[YxifGm4ZTD0c{Bkd262cn;s M3W0ZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3OUW4OVg6Lz5zNUm1PFU5QTxxYU6=
NCI-H929 M2rUZmFxd3C2b4Ppd{Bie3OjeR?= NGSwWnA{OCC3TR?= MYSzJIhzew>? MVzJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKE6FST3IPVI6KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCxZjDNZ4wuOSCycn;0[YlvKGyndnXsJIF1KDNyIIXNJIFnfGW{IEOgbJJ{KGK7IHntcZVvd2Kub4T0bY5o NX7ac|BRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW5OVg2QDlpPkG1PVU5PTh7PD;hQi=>
NCI-H929 M{fuZmFxd3C2b4Ppd{Bie3OjeR?= MWKzNEB2VQ>? NY[1bmVjOyCqcoO= NGLHWXlKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJIh2dWGwIF7DTU1JQTJ7IHPlcIx{KGG|c3Xzd4VlKGG|IHPoZY5o\XNiaX6gRoNtNTJicILveIVqdiCuZY\lcEBifCB|MDD1UUBi\nSncjCzJIhzeyCkeTDpcY12dm:kbH;0eIlv\w>? NXz1UWtHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW5OVg2QDlpPkG1PVU5PTh7PD;hQi=>
NCI-H929 M4DUemFxd3C2b4Ppd{Bie3OjeR?= MYOzNEB2VQ>? MnjEN{BpenN? NHi5O|FKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJIh2dWGwIF7DTU1JQTJ7IHPlcIx{KGG2IEOwJJVOKGGodHXyJFMhcHK|IIXzbY5oKFSXTlXMJJN1[WmwaX7nJIJ6KG[ub4egZ5l1d22ndIL5 NF3ZWmQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUm1PFU5QSd-MUW5OVg2QDl:L3G+
NCI-H929 NUjQSJVMSXCxcITvd4l{KGG|c3H5 MnL0N|AhfU1? MUKxMlUhcHK| MnXQTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCQQ1mtTFkzQSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25ib3[gVm5CKHCxbInt[ZJie2ViMjDwbI9{eGixc3XybY5mKDVibHX2[Ywh[XRiM{CgeW0h[W[2ZYKgNU42KGi{czDifUBqdW23bn;icI91fGmwZx?= NG\PNlg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUm1PFU5QSd-MUW5OVg2QDl:L3G+
NCI-H929 M{T2bGFxd3C2b4Ppd{Bie3OjeR?= MWCzNEB2VQ>? NWi0fJpVOS53IHjydy=> NUPWWZV1UW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDOR2kuUDl{OTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4YhUGSvMjDs[ZZmdCCjdDCzNEB2VSCjZoTldkAyNjViaILzJIJ6KGmvbYXuc4Jtd3S2aX7n NFy4T2U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUm1PFU5QSd-MUW5OVg2QDl:L3G+
NCI-H929 NX;jOXF{SXCxcITvd4l{KGG|c3H5 MYqzNEB2VQ>? NYLqSJZFOS53IHjydy=> NHzjd|hKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJIh2dWGwIF7DTU1JQTJ7IHPlcIx{KGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIH;mJJA2OyCjY3P1cZVt[XSrb36gZZQhOzBidV2gZYZ1\XJiMT61JIhzeyCkeTDpcY12dm:kbH;0eIlv\w>? M2PC[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3OUW4OVg6Lz5zNUm1PFU5QTxxYU6=
SK-N-MC MYXxTHRUKGG|c3H5 MlP4dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKFONLV6tUWMh[2WubIO= MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB6MEewN{c,OjFyOEC3NFM9N2F-
HCT116 Ml25SpVv[3Srb36gZZN{[Xl? NF64NpA{OCC2bzC0NEB2dW:uL1y= MmDiNlQhcHK| MorsTY5pcWKrdHnvckBw\iCleXPsbY4hSSCrbjDoeY1idiCKQ2SxNVYh[2WubIOgZZN{\XO|ZXSgZZMh\GWlcnXhd4UhcW5icILveIVqdiCuZY\lcEBifCB|MDD0c{A1OCC3bX;sM2wh[W[2ZYKgNlQhcHK|IHL5JIludXWwb3Lsc5R1cW6pIHHuZYx6e2m| MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB6MEewN{c,OjFyOEC3NFM9N2F-
HCT116 Mm\VSpVv[3Srb36gZZN{[Xl? MXWzNEB1dyB2MDD1cY9tN0x? MXOyOEBpenN? MVzJcohq[mm2aX;uJI9nKGO7Y3zpckBDKGmwIHj1cYFvKEiFVEGxOkBk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiCycn;0[YlvKGyndnXsJIF1KDNyIITvJFQxKHWvb3yvUEBi\nSncjCyOEBpenNiYomgbY1ufW6xYnzveJRqdmdiYX7hcJl{cXN? MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB6MEewN{c,OjFyOEC3NFM9N2F-
HCT116 NXrhS4J5TnWwY4Tpc44h[XO|YYm= MkOzN|AhfG9iNECgeY1wdC:O NYn6[|BtOjRiaILz NXrnXndkUW6qaXLpeIlwdiCxZjDjfYNtcW5iREGgbY4hcHWvYX6gTGNVOTF4IHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJJBzd3SnaX6gcIV3\WxiYYSgN|AhfG9iNECgeY1wdC:OIHHmeIVzKDJ2IHjyd{BjgSCrbX31co9jdG:2dHnu[{BidmGueYPpdy=> NFvKRnE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUC4NFcxOyd-MkGwPFA4ODN:L3G+
HCT116 NVXOVIFTTnWwY4Tpc44h[XO|YYm= NFnX[5M{OCC2bzC0NEB2dW:uL1y= NGC1Wm4zPCCqcoO= NXfVfZhRUW6qaXLpeIlwdiCxZjDDSGszKGmwIHj1cYFvKEiFVEGxOkBk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiCycn;0[YlvKGyndnXsJIF1KDNyIITvJFQxKHWvb3yvUEBi\nSncjCyOEBpenNiYomgbY1ufW6xYnzveJRqdmdiYX7hcJl{cXN? MnPEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFyOEC3NFMoRjJzMEiwO|A{RC:jPh?=
HT-29 NUniOYFqTnWwY4Tpc44h[XO|YYm= MnXUNk42KHSxIESwJJVO Mn\ONlQhcHK| NUS3Z28zUW6qaXLpeIlwdiCxZjDy[ZRqdm:kbHHzeI9u[SCycn;0[YlvKGmwIHj1cYFvKEiWLUK5JINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iCleXPsbY4hSSCuZY\lcEBifCB{LkWgeI8hPDBidV2gZYZ1\XJiMkSgbJJ{KGK7IHntcZVvd2Kub4T0bY5o MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTRzN{SxO{c,OjF2MUe0NVc9N2F-
MCF7 MlXGR4VtdCCleXPs[UBie3OjeR?= MWKyOEBpenN? M4G1cWNmdGxiY4njcIUh[XK{ZYP0JIlvKGi3bXHuJG1ETjdiY3XscJMh[XO|ZYPz[YQh[XNiYXPjeY12dGG2aX;uJIF1KEd{L12gdIhie2ViYX\0[ZIhOjRiaILzJJV{cW6pIIDyc5Bq\Gm3bTDpc4Rq\GViYX7kJGJz\FVic4ThbY5qdmdiYomg[oxwfyCleYTvcYV1enl? M{XI[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNEG3OFE4Lz5{MUSxO|QyPzxxYU6=
RPMI8226 MUjD[YxtKGO7Y3zlJIF{e2G7 NHvIbnIzPCCqcoO= NV\HT3F5S2WubDDjfYNt\SCjcoLld5QhcW5iaIXtZY4hWlCPSUiyNlYh[2WubIOgZZN{\XO|ZXSgZZMh[WOldX31cIF1cW:wIHH0JGczN01icHjhd4Uh[W[2ZYKgNlQhcHK|IIXzbY5oKHC{b4Dp[Il2dSCrb3Tp[IUh[W6mIFLy[HUhe3SjaX7pcoch[nliZnzve{BkgXSxbXX0dpk> NYftfpdGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0NVc1OTdpPkKxOFE4PDF5PD;hQi=>
MCF7 Mk\KR4VtdCCleXPs[UBie3OjeR?= MYGyOEBpenN? NFHLW4JE\WyuIHP5Z4xmKGG{cnXzeEBqdiCqdX3hckBOS0Z5IHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJHMheGijc3WgZ4VtdCCyb4D1cIF1cW:wIHHmeIVzKDJ2IHjyd{B2e2mwZzDwdo9xcWSrdX2gbY9lcWSnIHHu[EBDemSXIIP0ZYlvcW6pIHL5JIZtd3diY4n0c41mfHK7 MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTRzN{SxO{c,OjF2MUe0NVc9N2F-
MCF7 NYTXSlBxS2WubDDjfYNt\SCjc4PhfS=> NWXhW4J5OjRiaILz MlrSR4VtdCCleXPs[UBienKnc4SgbY4hcHWvYX6gUWNHPyClZXzsd{Bie3Onc4Pl[EBieyCjY3P1cZVt[XSrb36gZZQhe3WkLVexJJBp[XOnIHHmeIVzKDJ2IHjyd{B2e2mwZzDwdo9xcWSrdX2gbY9lcWSnIHHu[EBDemSXIIP0ZYlvcW6pIHL5JIZtd3diY4n0c41mfHK7 MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTRzN{SxO{c,OjF2MUe0NVc9N2F-
RPMI8226 NIXueplE\WyuIHP5Z4xmKGG|c3H5 M1rufFI1KGi{cx?= MkCyR4VtdCCleXPs[UBienKnc4SgbY4hcHWvYX6gVnBOUTh{Mk[gZ4VtdHNiYYPz[ZN{\WRiYYOgZYNkfW23bHH0bY9vKGG2IIP1Zk1IOSCyaHHz[UBi\nSncjCyOEBpenNidYPpcocheHKxcHnkbZVuKGmxZHnk[UBidmRiQoLkWUB{fGGrbnnu[{BjgSCobH;3JIN6fG:vZYTyfS=> Mn;FQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2MUe0NVcoRjJzNEG3OFE4RC:jPh?=
MCF7 NYH6VXhzS2WubDDjfYNt\SCjc4PhfS=> NITqVmM5OCC3TR?= MWqyOEBpenN? MYHD[YxtKGO7Y3zlJIFzemW|dDDpckBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCxZjDhZ5RqfmWueTDy[ZBtcWOjdHnu[{BFVkFibHX2[Ywh[XRiOECgeW0h[W[2ZYKgNlQhcHK|IIXzbY5oKHC{b4Dp[Il2dSCrb3Tp[IUh[W6mIFLy[HUhe3SjaX7pcoch[nliZnzve{BkgXSxbXX0dpk> Mnj4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2MUe0NVcoRjJzNEG3OFE4RC:jPh?=
MCF7 NUO1SIpITnWwY4Tpc44h[XO|YYm= MoTHNlAhfU1? MkjyNlQhcHK| NWjUSIlEUW6mdXP0bY9vKG:oIIC1N{1l\XCnbnTlcpQhfHKjboPjdolxfGmxbnHsJIFkfGm4aYT5JIlvKGi3bXHuJG1ETjdiY3XscJMh[XO|ZYPz[YQh[XNiaX7jdoVie2Vib3[gdFIyKFeDRkGgcIV3\WxiYYSgNlAhfU1iYX\0[ZIhOjRiaILzJIJ6KGmvbYXuc4ZtfW:{ZYPj[Y5k\SCjc4PhfS=> MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTRzN{SxO{c,OjF2MUe0NVc9N2F-
RPMI8226 NG\1dWJE\WyuIHP5Z4xmKGG|c3H5 MoLPNlQhcHK| Mnm5R4VtdCCleXPs[UBienKnc4SgbY4hcHWvYX6gVnBOUTh{Mk[gZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hWyCyaHHz[UBk\WyuIIDvdJVt[XSrb36gZYZ1\XJiMkSgbJJ{KHW|aX7nJJBzd3CrZHn1cUBqd2SrZHWgZY5lKEK{ZGWgd5RicW6rbnegZpkh\myxdzDjfZRwdWW2com= MlPsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2MUe0NVcoRjJzNEG3OFE4RC:jPh?=
RPMI8226 M17KUWNmdGxiY4njcIUh[XO|YYm= M1\2SFgxKHWP MmTENlQhcHK| M324UGNmdGxiY4njcIUh[XK{ZYP0JIlvKGi3bXHuJHJRVUl6MkK2JINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iCjY4TpeoVtgSC{ZYDsbYNifGmwZzDEUmEhdGW4ZXygZZQhQDBidV2gZYZ1\XJiMkSgbJJ{KHW|aX7nJJBzd3CrZHn1cUBqd2SrZHWgZY5lKEK{ZGWgd5RicW6rbnegZpkh\myxdzDjfZRwdWW2com= NEnHXnI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUSxO|QyPyd-MkG0NVc1OTd:L3G+
A549 MYLBdI9xfG:|aYOgZZN{[Xl? NV3JXVhkOiC3TR?= MXS0PEBpenN? MXXJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKEF3NEmgZ4VtdHNiYYPz[ZN{\WRiYYOgSG5CKG[{YXft[Y51[XSrb36gZZQhOiC3TTDh[pRmeiB2ODDodpMh[nliYXfhdo9{\SCpZXyg[Yxm[3S{b4Doc5Jme2m| MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ{M{S5NUc,OjN4MkO0PVE9N2F-
Sf9 MXLGeY5kfGmxbjDhd5NigQ>? M1zGZ|ExKG2rboO= M3nFcmlvcGmkaYTpc44hd2ZiSHnzMVYufGGpZ3XkJJJm[2:vYnnuZY51KGi3bXHuJGNFUzJxY4njcIlvTSCneIDy[ZN{\WRiaX6gZoFkfWyxdnnyeZMucW6oZXP0[YQhe2Z7IHPlcIx{KHW|aX7nJIhqe3SxbnWgTFEh[XNic4Xid5Rz[XSnIHHmeIVzKDFyIH3pcpMh[nlibHnxeYllKHOlaX70bYxt[XSrb36gZ492dnSrbnegbY4heHKnc3XuZ4Uhd2ZiW3fhcY1iNTN{UG3BWHAtKEmFNUCgQUAxNjFizszNMi=> NYK3VXI3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS0NVc2PjZpPkK0OFE4PTZ4PD;hQi=>
BJ MlqySpVv[3Srb36gZZN{[Xl? MnzGNVAhfU1? MWKxNEBl[Xm| NEXXdItUfXCycnXzd4lwdiCxZjDz[Y5me2OnbnPlJIlvKGi3bXHuJGJLKGOnbHzzJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHPlcIwhdnWvYnXyJIF1KDFyIIXNJIFnfGW{IEGwJIRigXNiYomgd4Vv\XOlZX7j[UBz\X[ncoPhcEBie3OjeR?= MmPYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4OEG5PFYoRjJ2NkixPVg3RC:jPh?=
BJ NF\ETFRHfW6ldHnvckBie3OjeR?= NVzoe4luOTBidV2= NVnSSlJSOTBiZHH5dy=> NHHZUo9KdmirYnn0bY9vKG:oIHH0ZZhq[SC2ZXzhcodq\WO2YYPpZU1ufXSjdHXkJIlvKGi3bXHuJGJLKGOnbHzzJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHPlcIwhdnWvYnXyJIF1KDFyIIXNJIFnfGW{IEGwJIRigXNiYomgd4Vv\XOlZX7j[UBz\X[ncoPhcEBie3OjeR?= NUHF[VZJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2PFE6QDZpPkK0OlgyQTh4PD;hQi=>
MCF7 M1rPSGZ2dmO2aX;uJIF{e2G7 MoDBNVAhfU1? NYTlOZBqOTBibXnudy=> NYS5N3B7W2Wwc3n0bZpifGmxbjDv[kBqdm[{YYLl[E1qdmS3Y3XkJGRPSSCmYX3h[4UhcW5iaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2:ub375JIZwem2jdHnvckBifCBzMDD1UUBxemW2cnXheIVlKG[xcjCxNEBucW6|IH\vcIxwf2WmIHL5JIlzemGmaXH0bY9vKG[xcjC0JIhzeyCvZXHzeZJm\CCjZoTldkAyOCCmYYnzJIJ6KGO{eYP0ZYwhfmmxbHX0JJN1[WmwaX7nJIFv[Wy7c3nz M3m0R|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OEWxOVA2Lz5{Nki1NVUxPTxxYU6=
Caco2 MnLlR4VtdCCleXPs[UBie3OjeR?= Ml\jR4VtdCCleXPs[UBienKnc4SgbY4hcHWvYX6gR4FkdzJiY3XscJMh[XO|ZYPz[YQh[XNiYXPjeY12dGG2aX;uJIF1KEdzL2OgdIhie2ViYomgTI9m[2i|dDDzeIFqdmmwZzDiZZNm\CCobIXvdoV{[2WwY3WgZZN{[Xl? M{P0T|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MkG0NlMyLz5{OEKxOFI{OTxxYU6=
HaCaT NUPEfFhtS2WubDDjfYNt\SCjc4PhfS=> MWfD[YxtKGO7Y3zlJIFzemW|dDDpckBpfW2jbjDIZWNiXCClZXzsd{Bie3Onc4Pl[EBieyCjY3P1cZVt[XSrb36gZZQhTzFxUzDwbIF{\SCkeTDIc4VkcHO2IIP0ZYlvcW6pIHLhd4VlKG[udX;y[ZNk\W6lZTDhd5NigQ>? MmLGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{MUSyN|EoRjJ6MkG0NlMyRC:jPh?=
HuH7 NWnKWFd4S2WubDDjfYNt\SCjc4PhfS=> NYHFWVJVS2WubDDjfYNt\SCjcoLld5QhcW5iaIXtZY4hUHWKNzDj[YxteyCjc4Pld5Nm\CCjczDhZ4N2dXWuYYTpc44h[XRiR{GvV{BxcGG|ZTDifUBJd2WlaIP0JJN1[WmwaX7nJIJie2WmIH\seY9z\XOlZX7j[UBie3OjeR?= NIC1PVM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEKxOFI{OSd-MkiyNVQzOzF:L3G+
PC3 M{LsS2NmdGxiY4njcIUh[XO|YYm= MVvD[YxtKGO7Y3zlJIFzemW|dDDpckBpfW2jbjDQR|Mh[2WubIOgZZN{\XO|ZXSgZZMh[WOldX31cIF1cW:wIHH0JGczN01icHjhd4Uh[nliSH;lZ4h{fCC|dHHpcolv\yCkYYPl[EBndHWxcnXzZ4Vv[2ViYYPzZZk> M2LrRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MkG0NlMyLz5{OEKxOFI{OTxxYU6=
MDA-MB-231 M3uzWGNmdGxiY4njcIUh[XO|YYm= NFXlbJlE\WyuIHP5Z4xmKGG{cnXzeEBqdiCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIF{e2W|c3XkJIF{KGGlY4XteYxifGmxbjDheEBIOS:VIIDoZZNmKGK7IFjv[YNpe3Ric4ThbY5qdmdiYnHz[YQh\my3b4Lld4NmdmOnIHHzd4F6 MlzUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{MUSyN|EoRjJ6MkG0NlMyRC:jPh?=
HCT116 NXrFT3JGS2WubDDjfYNt\SCjc4PhfS=> NITWWmhE\WyuIHP5Z4xmKGG{cnXzeEBqdiCqdX3hckBJS1RzMU[gZ4VtdHNiYYPz[ZN{\WRiYYOgZYNkfW23bHH0bY9vKGG2IFexM3MheGijc3WgZpkhUG:nY3jzeEB{fGGrbnnu[{Bj[XOnZDDmcJVwemW|Y3XuZ4Uh[XO|YYm= MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJzNEKzNUc,Ojh{MUSyN|E9N2F-
SK-N-MC MVrxTHRUKGG|c3H5 MVrxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhW0tvTj3NR{Bk\Wyucx?= MkTqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3NUe0N|AoRjJ6NUW3OFMxRC:jPh?=
A673 MkTDdWhVWyCjc4PhfS=> M{jMXpFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCDNkezJINmdGy| MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
DAOY M1PDOZFJXFNiYYPzZZk> Ml65dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKESDT2mgZ4VtdHN? NEPYPYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
BT-37 MXvxTHRUKGG|c3H5 MVLxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhSlRvM{egZ4VtdHN? M3;ETlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SJ-GBM2 NV7jRWVreUiWUzDhd5NigQ>? NUj3UXBveUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IGPKMWdDVTJiY3XscJM> NYq1TJRTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
LAN-5 MmDQdWhVWyCjc4PhfS=> MWfxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhVEGQLUWgZ4VtdHN? MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
SK-N-MC MUXxTHRUKGG|c3H5 NF3BWXNyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiU1utUk1OSyClZXzsdy=> NXXZSmNJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxPVk4ODJpPkOwNVk6PzB{PD;hQi=>
Assay
Methods Test Index PMID
Western blot pT231-tau / pS202-tau / tau p-Rb / p-CDK2 / CDK2 / Cyclin D1 / Cyclin A2 / ERα / ERβ/ AIB1 / PELP1 30915013 21834972
Immunofluorescence CDK1 / Smek2 / FUBP1 / Cdc20 E2F1 / FASN / Bmi1 / Cyclin D2 / CDK2 / CDK4 24534090 20890301
Growth inhibition assay Cell viability 29996940
体内研究 Roscovitine按50 mg/kg剂量作用于Ewing's肉瘤家族(ESFT)移植瘤,明显抑制肿瘤生长。[4] Roscovitine作用于携带MCF7移植瘤的裸鼠,增强抗癌Doxorubicin抗癌效果,不会提高毒性,机制是使细胞周期停滞而不是引起凋亡。[5]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[1]
  • 酶实验:

    激酶活性实验在30oC下buffer C中进行。从数据中除去空白值,在10分钟的温育期中测定渗透到蛋白受体中的磷酸摩尔数,来计算活性。对照组用适当稀释的DMSO处理。在一些情况下, SDS/PAGE后通过自动射线照相术测定底物磷酸化。p34cdc2/cyclin B通过亲和色谱从 M期海星卵母细胞中纯化。使用 1 mg 组蛋白Hl/mL,在15 μM [γ-32P]ATP存在时进行实验,终浓度为 30 μL。在 30oC下温育10分钟, 25-μL上清液 转移到Whatman P81磷酸纤维素纸上, 20秒后, 用10mL磷酸/L水冲洗过滤器5次,每次至少5分钟。湿式过滤器转移到 6 mL闪烁管,加入5 mL ACS闪烁液,使用Packard 计数器测定放射性。测定在10分钟温育期中组蛋白H1渗透放入磷酸摩尔数评估激酶活性或者最大活性百分数。感染不同杆状病毒的sf9昆虫细胞抽提物中再生p33cdk2/cyclin A和p33cdk2/cyclinE。Cyclins A 和E是谷胱甘肽S-转移酶融合蛋白,复合体从谷胱甘肽-琼脂糖珠上纯化。使用 1 mg/mL 组蛋白Hl/mL,在15 μM [γ-32P]ATP存在时,进行激酶活性实验10分钟,终体积为30 μL,测定p34cdc2/cyclin B激酶。p33cdk5/p35从牛脑中纯化,除了Mono S-色层分离一步法。 Superose 12柱的活性片段汇集,终浓度为25 μg 酶/mL。使用1 mg/mL 组蛋白Hl, 在15 μM [γ-32P]ATP存在时,进行激酶活性实验10分钟,终体积为 30 μL,测定p34cdc2/cyclin B激酶。

细胞实验:[1]
  • Cell lines: 白血病, 非小细胞肺癌,结肠癌, 中枢神经系统肿瘤, 恶性黑色素瘤,卵巢癌,肾癌, 前列腺癌,胸腺癌细胞系
  • Concentrations: 0.01到100 μM
  • Incubation Time: 48小时
  • Method: 包括9种肿瘤类型的60种人类肿瘤细胞系培养24小时,然后用 0.01-100 μM Roscovitine持续处理48小时。进行sulforhodaminine B蛋白实验测评毒性。
动物实验:[4
  • Animal Models: 右后侧皮下注射A4573细胞的CD1 nu/nu鼠
  • Dosages: ≤50 mg/kg
  • Administration: 腹腔注射

溶解度(25°C)

体外

体内

从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O

10mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 354.45
化学式

C19H26N6O

CAS号 186692-46-6
储存条件 3年 -20°C 粉状
2年 -80°C 溶于溶剂

动物体内配方计算器(澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)

mg/kg g μL

第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于μL DMSO溶液(母液浓度mg/mL,:如该浓度超过该批次药物DMSO溶解度,请先联系Selleck);

体内配方配制方法:μL DMSO母液,加入μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入μL ddH2O,混匀澄清。

体内配方配制方法:μL DMSO母液,加入μL Corn oil,混匀澄清。

注意:1. 首先保证母液是澄清的;
2.一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。

摩尔浓度计算器

质量 浓度 体积 分子量

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02649751 Terminated Drug: Roscovitine|Drug: Placebo Cystic Fibrosis University Hospital Brest|ManRos Therapeutics|Cyclacel Pharmaceuticals Inc. February 22 2016 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-08-01)

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

* 必填项

请输入您的姓名
请输入您的邮箱地址 请输入一个有效的邮箱地址
请写点东西给我们

常见问题及建议解决方法

问题 1:
How can I reconstitute the drug for in vivo studies?

回答:
S1153 in 1% DMSO+10% Tween 80+20% N-N-dimethylacetamide+PEG 400 is a clear solution which is okay for injection. And S1153 in 1% DMSO+30% polyethylene glycol+1% Tween 80 at 30mg/ml is a suspension, which is fine for oral gavage.

Tags: buy Roscovitine (CYC202) | Roscovitine (CYC202) supplier | purchase Roscovitine (CYC202) | Roscovitine (CYC202) cost | Roscovitine (CYC202) manufacturer | order Roscovitine (CYC202) | Roscovitine (CYC202) distributor