SNS-032 (BMS-387032)

For research use only. Not for use in humans.

目录号:S1145

SNS-032 (BMS-387032) Chemical Structure

CAS No. 345627-80-7

SNS-032 (BMS-387032)最初被描述为选择性CDK2抑制剂,无细胞试验中IC50为48 nM,比作用于CDK1/CDK4选择性高10和20倍。它也对CDK7/9敏感,IC50为62 nM/4 nM,对CDK6几乎没有抑制效果。SNS-032 (BMS-387032)可诱导凋亡。Phase 1。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1414.37 现货
RMB 901.17 现货
RMB 4675.34 现货
RMB 13677.3 现货
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客户使用Selleck生产的SNS-032 (BMS-387032)发表文献58篇:

产品安全说明书

CDK抑制剂选择性比较

生物活性

产品描述 SNS-032 (BMS-387032)最初被描述为选择性CDK2抑制剂,无细胞试验中IC50为48 nM,比作用于CDK1/CDK4选择性高10和20倍。它也对CDK7/9敏感,IC50为62 nM/4 nM,对CDK6几乎没有抑制效果。SNS-032 (BMS-387032)可诱导凋亡。Phase 1。
特性 SNS-032是新一代CDK抑制剂,具有更高的选择性和更弱的毒性。
靶点
CDK9/CyclinT [3]
(Cell-free assay)
CDK2/CyclinA [3]
(Cell-free assay)
CDK2/CyclinE [1]
(Cell-free assay)
CDK7/CyclinH [3]
(Cell-free assay)
GSK-3α [3]
(Cell-free assay)
4 nM 38 nM 48 nM 62 nM 230 nM
体外研究

SNS-032是新型有效的选择性Cdk抑制剂, 有效抑制Cdk2, Cdk7和Cdk9。体外,不管病情预断和治疗病史如何,SNS-032都可有效杀死慢性淋巴细胞性白血病细胞。与Flavopiridol和Roscovitine相比, 抑制RNA合成和诱导细胞凋亡时,SNS-032更有效。SNS-032是可逆的,使SNS-032重激活RNA聚合酶II失活, 导致Mcl-1再合成和细胞存活。[1] SNS-032抑制内皮细胞的三维毛细管网形成。SNS-032作用于人脐静脉内皮细胞(HUVECs),完全抑制U87MG细胞调节的毛细管形成。此外, SNS-032明显抑制VEGF的产生,从而抑制血管生成。临床前期研究显示SNS-032跨多种细胞系诱导细胞周期停滞和细胞凋亡。[2]SNS-032通过抑制 CDKs 2和7而阻断细胞周期, 通过抑制CDKs 7和9阻断转录。SNS-032的活性不受人类血清影响。[3] SNS-032诱导膜联蛋白V染色增多和caspase-3激活,这种作用存在剂量依赖性。在分子水平, SNS-032诱导RNA多聚酶(RNA Pol) II 在serine 2和5位点去磷酸化。且抑制CDK2,CDK9。和去磷酸化的CDK7的表达。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human A2780 cell line M2DJZXBzd2yrZnXyZZRqd25iYYPzZZk> M4O1NlczKGh? M4DQUmFvfGmycn;sbYZmemG2aY\lJIVn\mWldDDh[4FqdnO2IHj1cYFvKEF{N{iwJINmdGxibHnu[UB4[XNiZHX0[ZJucW6nZDDpckBiKHeqb3zlJINmdGxiN{KgbJIh[3m2b4TvfIlkcXS7IHHzd4F6NCCLQ{WwQVk2KG6P NXK5PWVZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUWwNlc5PjNpPkG1NFI4QDZ|PD;hQi=>
Sf21 MWDGeY5kfGmxbjDhd5NigQ>? MX7Jcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IHj1cYFvKG[3bHygcIVv\3SqIFOteIVzdWmwYXygTIl{Pi22YXfn[YQhS0SNOT;jfYNtcW5iVEGg[ZhxemW|c3XkJIlvKGKjY4Xsc5ZqenW|IHnu[oVkfGWmIGPmNlEhcW6|ZXP0JINmdGy|IIXzbY5oKFCGS4Tp[IUh[XNic4Xid5Rz[XSnLDDJR|UxRTBwMEC0{txO M{Oyc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUexNFM3Lz5{N{G3NVA{PjxxYU6=
Sf21 NFvUXINHfW6ldHnvckBie3OjeR?= NFq5fWNKdmirYnn0bY9vKG:oIHj1cYFvKG[3bHygcIVv\3SqIFOteIVzdWmwYXygTIl{Pi22YXfn[YQhS0SNMj;OMZRmem2rbnHsJGdUXC22YXfn[YQh[3mlbHnuJGEh\XiycnXzd4VlKGmwIHLhZ5Vtd3[rcoXzJIlv\mWldHXkJHNnOjFiaX7z[YN1KGOnbHzzJJV{cW6pIHjpd5RwdmViSEGgZZMhe3Wkc4TyZZRmNCCLQ{WwQVAvODN6zszN MnzQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzN{GwN|YoRjJ5MUexNFM3RC:jPh?=
Sf21 NWPzdJJ7TnWwY4Tpc44h[XO|YYm= NVTjTHE2UW6qaXLpeIlwdiCxZjDy[YNwdWKrbnHueEBpfW2jbjDmeYxtKGynbnf0bEBENXSncn3pcoFtKEirc{[teIFo\2WmIFPET|IwVi22ZYLtbY5idCCJU2SteIFo\2WmIHP5Z4xqdiCHIHX4dJJme3OnZDDpckBj[WO3bH;2bZJ2eyCrbn\lZ5Rm\CCVZkKxJIlve2WldDDj[YxteyC3c3nu[{BpcXO2b37lJGgyKGG|IIP1ZpN1emG2ZTygTWM2OD1yLkC0PO69VQ>? M{fkOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUexNFM3Lz5{N{G3NVA{PjxxYU6=
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Sf21 M{D0fGZ2dmO2aX;uJIF{e2G7 NV65PXhPUW6qaXLpeIlwdiCxZjDy[YNwdWKrbnHueEBpfW2jbjDmeYxtKGynbnf0bEBPNXSncn3pcoFtKEirc{[teIFo\2WmIFPET|UwVi22ZYLtbY5idCCJU2SteIFo\2WmIICyOUBmgHC{ZYPz[YQhcW5iYnHjeYxwfmm{dYOgbY5n\WO2ZXSgV4YzOSCrboPlZ5Qh[2WubIOgeZNqdmdiaHnzeI9v\SCKMTDhd{B{fWK|dILheIUtKEmFNUC9NE4{PM7:TR?= NVnZdWZHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexO|ExOzZpPkK3NVcyODN4PD;hQi=>
HCT116 MVzGeY5kfGmxbjDhd5NigQ>? M1PYUVE3KGi{cx?= NX3He|hYUW6qaXLpeIlwdiCxZjDDSGs6KGmwIHj1cYFvKEiFVEGxOkBk\WyuczDhd5Nme3OnZDDhd{BxcG:|cHjvdk1{\XJ{IHzleoVtKG:oIGLORUBxd2y7bXXyZZNmKDJiYX\0[ZIhOTZiaILzJIJ6KGirZ3igZ49vfGWwdDDj[YxtfWyjcjDhd5NigSxiSVO1NF0xNjR3ON88US=> MkDSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh6NEK0NFkoRjF6OESyOFA6RC:jPh?=
Sf21 MmS0SpVv[3Srb36gZZN{[Xl? NIjLeWZKdmirYnn0bY9vKG:oIHj1cYFvKG[3bHygcIVv\3SqIFOteIVzdWmwYXygTIl{Pi22YXfn[YQhS0SNMT;OMZRmem2rbnHsJGdUXC22YXfn[YQh[3mlbHnuJGIh\XiycnXzd4VlKGmwIHLhZ5Vtd3[rcoXzJIlv\mWldHXkJHNnOjFiaX7z[YN1KGOnbHzzJJV{cW6pIHjpd5RwdmViSEGgZZMhe3Wkc4TyZZRmNCCLQ{WwQVAvPDkQvF2= NUjTRYNURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexO|ExOzZpPkK3NVcyODN4PD;hQi=>
HCT116 NIT6O2FHfW6ldHnvckBie3OjeR?= MmXlNVYhcHK| M4fNbWlvcGmkaYTpc44hd2ZiQ1TLPU1u\WSrYYTl[EBTVkFicH;sJFIheGixc4Doc5J6dGG2aX;uJIF1KHOnckKgbY4hcHWvYX6gTGNVOTF4IHPlcIx{KGGodHXyJFE3KGi{czDifUBJS1NiYYPzZZktKEmFNUC9NE42Pc7:TR?= MmjOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh7Mk[2PVkoRjF6OUK2Olk6RC:jPh?=
HCT116 NIS3fItCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MlnnNlQhcHK| MlryRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ2SxNVYh[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1yLkhOwG0> MnXhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzBzOUewNlkoRjNyMUm3NFI6RC:jPh?=
Sf cells M37SUGZ2dmO2aX;uJIF{e2G7 MUjJcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IHj1cYFvKE5vdHXycYlv[WxiR2PUMZRi\2enZDDDSGs1N2O7Y3zpckBFOSCneIDy[ZN{\WRiaX6gZoFkfWyxdnnyeZMhcW6oZXP0[YQhe2ZiY3XscJMtKEmFNUC9NE46OjYQvF2= MoH2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzN{GwN|YoRjJ5MUexNFM3RC:jPh?=
MCF7 M3TWd2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 MVqyOEBpenN? MVjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0y|ryP Mn\jQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzBzOUewNlkoRjNyMUm3NFI6RC:jPh?=
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SK-N-SH MV3xTHRUKGG|c3H5 MmP5dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKFONLV6tV2gh[2WubIO= NWfBPYc1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
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BT-12 MlTEdWhVWyCjc4PhfS=> NW[2cZNLeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhSlRvMUKgZ4VtdHN? NES5T4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
LAN-5 M3LtT5FJXFNiYYPzZZk> M1uxUZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJGxCVi13IHPlcIx{ M4LaPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
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SJ-GBM2 Mn;idWhVWyCjc4PhfS=> NX;WOZVueUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhW0pvR1LNNkBk\Wyucx?= NGXaOYU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
BT-37 NXHHbnpLeUiWUzDhd5NigQ>? NGDTVlZyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBDXC1|NzDj[Yxtew>? MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
TC32 MmTsdWhVWyCjc4PhfS=> MXjxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDUR|MzKGOnbHzz MlztQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
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OHS-50 MlzrdWhVWyCjc4PhfS=> NUXNRVM4eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhV0iVLUWwJINmdGy| NWHPeGo2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
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... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-RNA PolII / RNA Pol II / CDK7 / CDK9 ; 

PubMed: 31526394     


SNS-032 inhibited CTD phosphorylation of RNA Pol II in UM cells. Cells were treated with increasing concentration of SNS-032 for 48 h, Western blot analysis with the indicated antibodies was performed.

YAP / p-YAP / CTGF / CYR61 ; 

PubMed: 31526394     


SNS-032 blocked YAP signaling in UM cells. Mel270 and Omm2.3 cells were treated with SNS-032 for 48 h, the protein levels of YAP, phospho-YAP (S127) and its downstream targets CTGF and CYR61 were examined by Western blot analysis. 

p-ROCK / ROCK / p-LIMK1/2 / LIMK1/2 / p-Cofilin / Cofilin ; 

PubMed: 31526394     


SNS-032 inhibited the RhoA-ROCK-LIMK1/2-cofilin pathway. Mel270 and Omm2.3 cells were treated with increasing concentrations of SNS-032 for 48 h, and then subjected to Western blot analysis with the indicated antibodies.

Mcl-1 / Cyclin D1 / Bcl-2 / PARP ; 

PubMed: 20663900     


SNS-032 reduced the protein levels of Mcl-1 and cyclin D1 and induced apoptosis.

31526394 20663900
Growth inhibition assay
Cell viability; 

PubMed: 20663900     


SNS-032 inhibited proliferation of the four MCL cell lines. MCL cells were seeded on 24 well plates, SNS-032 at concentrations of 0 (○), 0.03, (●), 0.1 (◆), 0.3 (▼), 1 (▲) and 3 (■) μM were added the next day. Cell concentrations were measured at 24, 48 and 72 h after addition of SNS-032. Data (mean +/− SD) represent percentage of cell growth compared to day 1 of three independent experiments.

20663900
体内研究 SNS-032作用于肿瘤共培养模型,阻断肿瘤细胞诱导的VEGF分泌。[2] SNS-032, 作用于实体瘤时具有更高选择性,且毒性较弱。[4]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:[2]
- 合并
  • Cell lines: HUVECs和U87MG细胞
  • Concentrations: 0-0.5 mM
  • Incubation Time: 24, 48, 或72小时
  • Method: U87MG细胞和HUVECs (每孔2000个细胞)接种在96孔板上,终体积为100 ml。24小时后,用不同浓度SNS-032(0-0.5 mM)处理细胞24,48,或72小时。完全处理后, 每孔加入100 mL CTG溶液,室温下黑暗温育20分钟。50 mL溶解物转移到96孔板上,通过POLARstar OPTIMA测定荧光值。计算加入SNS-032后的细胞生长百分数。
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 76 mg/mL (199.72 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
30% PEG400+0.5% Tween80+5% propylene glycol
30 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 380.53
化学式

C17H24N4O2S2

CAS号 345627-80-7
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

CDK Signaling Pathway Map

CDK Inhibitors with Unique Features

相关CDK产品

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID