Palbociclib (PD0332991) Isethionate

For research use only. Not for use in humans.

Pfizer辉瑞授权生产目录号：S1579

Palbociclib (PD0332991) Isethionate Chemical Structure

CAS No. 827022-33-3

Palbociclib (PD0332991) Isethionate是一种高度选择性的CDK4/6抑制剂，无细胞试验中IC50为11 nM/16 nM，对CDK1/2/5，EGFR，FGFR，PDGFR， InsR等没有抑制活性。Phase 3。

规格

价格

库存

购买数量

10mg	RMB 1217.51	现货
25mg	RMB 2189.47	现货
50mg	RMB 3026.06	现货
200mg	RMB 8763.3	现货
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客户使用Selleck生产的Palbociclib (PD0332991) Isethionate发表文献240篇：

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PubMed: 22761470 ( click the link to review the publication )

Cancer Prev Res (Phila), 2012, 5(6):810-21

PubMed: 22508966 ( click the link to review the publication )

Biochem Biophys Res Commun, 2012, 428(1):121-6

PubMed: 23063976 ( click the link to review the publication )

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PubMed: 22443451 ( click the link to review the publication )

Clin Cancer Res, 2011, 1;17(13):4513-22

PubMed: 21593195 ( click the link to review the publication )

产品安全说明书

CDK抑制剂选择性比较

生物活性

产品描述

特性

PD 0332991治疗多种癌症，特异性抑制CDK4/6，是第一种有前途的抑制剂。

靶点

CDK4/CyclinD3 ^[1] (Cell-free assay)	CDK4/CyclinD1 ^[1] (Cell-free assay)	CDK6/CyclinD2 ^[1] (Cell-free assay)
9 nM	11 nM	15 nM

体外研究

PD 0332991对CDK4/6具有绝对选择性，对其他CDKs几乎没有抑制活性。PD 0332991作用于MDA-MB-435乳腺癌细胞，有效降低Rb在Ser780 和 Ser795位点磷酸化，IC50分别为66 nM和63 nM。PD 0332991通过抑制细胞进入S期，有效抑制细胞生长，抑制 DNA复制。PD 0332991抑制胸苷渗透进Rb阳性人类乳腺癌(如MDA-MB-435, MCF-7), 结肠癌 (H1299), 和肺癌(Colo-205) 及白血病(CRRF-CEM和K562)的DNA中，IC50值为0.04-0.17 μM。PD 0332991显著增强MDA-MB-453在G1期的百分比。^[1]PD 0332991作用于CD138⁺原发性骨髓瘤细胞，初级非转化的B细胞，MM1.S和CAG HMCLs细胞系，抑制Rb磷酸化，IC50分别为 <0.1 μM, 0.05 μM, 和 60-70 nM。PD 0332991作用于CD138⁺原发性骨髓瘤细胞和初级非转化的B细胞，诱导细胞停滞在G1期。PD 0332991诱导MM1.S细胞停滞在G1期，IC50为~0.05 μM。^[2]PD 0332991优先抑制Luminal雌激素受体阳性(包括HER2阳性)人类乳腺癌细胞系。PD 0332991作用于大部分敏感的细胞系，促进pRb和cyclin D1基因表达，且降低CDKN2A(p16)基因表达。PD 0332991作用于条件性抗ER抑制的细胞系，增强对Tamoxifen的敏感性。^[3]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
H157	NEfUcZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGfiUHoxNTFyMDFOwG0>	MkTxO\|IhcA>?		MXnJR\|UxRTlizszN	NEXHeFQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkO5NFM1Oid-Mk[zPVA{PDJ:L3G+
H2170	NW\IVWdmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHnYcnUxNTFyMDFOwG0>	NHflemU4OiCq		NYn3b\|RWUUN3ME21JO69VQ>?	MnPmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ\|OUCzOFIoRjJ4M{mwN\|QzRC:jPh?=
H520	NGniNYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIXrV4cxNTFyMDFOwG0>	MorFO\|IhcA>?		NUTLXI9OUUN3ME2wMlc{KM7:TR?=	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjN7MEO0Nkc,OjZ\|OUCzOFI9N2F-
H596	NELpOFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWCwMVExOCEQvF2=	M2rIe\|czKGh?		MWnJR\|UxRTF{IN88US=>	NXuzTo9IRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zPVA{PDJpPkK2N\|kxOzR{PD;hQi=>
IMR-32	MnPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		M4HCXVQ5yqCq	NYjVe\|VzTE2VTx?=	M13J[GlEPTB;Mk[xJI5O	NEfWcI09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkKyOVEzOyd-Mk[yNlUyOjN:L3G+
SH-SY5Y	NX[4[WdQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NVnQNmtjPDkEoHi=	NY\vWWs{TE2VTx?=	Ml7hTWM2OD14N{[gcm0>	NInpeo09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkKyOVEzOyd-Mk[yNlUyOjN:L3G+
NGP	NIH3ZZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MUe0POKhcA>?	M{PRSmROW09?	MoHiTWM2OD1{LkC3O{DPxE1?	NXvLVW5kRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[yNlUyOjNpPkK2NlI2OTJ\|PD;hQi=>
SH-EP	MojDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NHruVVg1QMLiaB?=	MkXWSG1UVw>?	MYTJR\|UxRTJwMkGxJO69VQ>?	MlLRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ{MkWxNlMoRjJ4MkK1NVI{RC:jPh?=
IMR-32	NU[5d2V2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1[5OFEh\|ryP	MljzNlQhcA>?	M2DuV2ROW09?	NFjtSIJqdmS3Y3XzJGcyKGG{cnXzeC=>	M2HRV\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MkK1NVI{Lz5{NkKyOVEzOzxxYU6=
SH-SY5Y	NWjkcIgzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXrvV5VJOSEQvF2=	MorRNlQhcA>?	MYDEUXNQ	NIr1dotqdmS3Y3XzJGcyKGG{cnXzeC=>	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ{NUGyN{c,OjZ{MkWxNlM9N2F-
NGP	MnXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUPPZ4dpOSEQvF2=	NUHpbFhYOjRiaB?=	Mk\mSG1UVw>?	MVXpcoR2[2W\|IFexJIFzemW\|dB?=	NWrQUGx5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[yNlUyOjNpPkK2NlI2OTJ\|PD;hQi=>
SH-EP	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlXlNUDPxE1?	MlfLNlQhcA>?	MmKySG1UVw>?	Mk[xbY5lfWOnczDHNUBienKnc4S=	NVqwXXp6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[yNlUyOjNpPkK2NlI2OTJ\|PD;hQi=>
NGP	MVzGeYN1cW:wIFHzd4F6	M{PJdFAuOSEQvF2=	MVeyOEBp	M1[2S2ROW09?	MmHtdoVlfWOnczD0bIUh\XiycnXzd4lwdiCxZtMgWG9ROkFuwrDDR25GOixiYX7kxsBVUzIEoHnuJIEh\G:\|ZT3k[ZBmdmSnboSgcYFvdmW{	NWjDPGpjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[yNlUyOjNpPkK2NlI2OTJ\|PD;hQi=>
IMR-32	NITuc5dHfWO2aX;uJGF{e2G7	MkTrNE0yKM7:TR?=	NWjHVnVPOjRiaB?=	M2XEU2ROW09?	MXvy[YR2[2W\|IITo[UBmgHC{ZYPzbY9vKG:owrDUU3AzSS{EoFPDUmUzNCCjbnVCpHRMOcLiaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ?	NWfLOJk6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[yNlUyOjNpPkK2NlI2OTJ\|PD;hQi=>
U-CH2	M{DJWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mn3aNE0yKM7:TR?=	NXn5cpB6PzJiaB?=		NUP3bGw{UUN3ME21NE4zKG6P	M3PHfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MUizPVI2Lz5{NkG4N\|kzPTxxYU6=
U-CH3	MmLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXTtdYlEOC1zIN88US=>	M3nKbFczKGh?		MmjXTWM2OD13MjDuUS=>	M4XCSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MUizPVI2Lz5{NkG4N\|kzPTxxYU6=
U-CH6	M1fmcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M17pOlAuOSEQvF2=	NGrvWoo4OiCq		NW\FcJFHUUN3ME25NEBvVQ>?	M2PSPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MUizPVI2Lz5{NkG4N\|kzPTxxYU6=
U-CH7	MomwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIf0fmIxNTFizszN	NHSxNnE4OiCq		M4PZWGlEPTB;OUigcm0>	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF6M{myOUc,OjZzOEO5NlU9N2F-
U-CH11	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUCwMVEh\|ryP	NGSwSWQ4OiCq		NIfVOHBKSzVyPUO0NEBvVQ>?	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF6M{myOUc,OjZzOEO5NlU9N2F-
MCF7	MYPGeYN1cW:wIFHzd4F6	MXGyMlUuOjVyIH7N	M3;YdlI1KGh?		NFzkVXNz\WS3Y3XzJHJjKHCqb4PwbI9zgWyjdHnvci=>	MlXWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV7OUG4NVcoRjJ3OUmxPFE4RC:jPh?=
MV4-11	NX7CZVlkSXCxcITvd4l{KEG\|c3H5	NE\kfmsxNjVizszN	MV2yOEBp		MnHk[Y5p[W6lZYOgZZBweHSxc3nzJIlv\HWlZXSgZpkhe2:{YX\lcoljKGGwZDDBR\|IzOA>?	M3Lp[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NEi3PVE4Lz5{NUS4O\|kyPzxxYU6=
MOLM13	NXW4cmlQSXCxcITvd4l{KEG\|c3H5	NVjmbpNUOC53IN88US=>	Mny4NlQhcA>?		M3rCOIVvcGGwY3XzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KHOxcnHm[Y5q[iCjbnSgRWMzOjB?	M3;YV\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NEi3PVE4Lz5{NUS4O\|kyPzxxYU6=
MOLM13-ITD alone	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NG\YOYpKSzVyPUCuNFg6KMLzIECuNFA6KM7:TR?=	M3TNRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NEi3PVE4Lz5{NUS4O\|kyPzxxYU6=
MV4-11-ITD alone	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnXJTWM2OD1yLkC5NkDDuSByLkCwPEDPxE1?	NX3pS3poRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW0PFc6OTdpPkK1OFg4QTF5PD;hQi=>
MOLM13-ITD/D835Y	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlS3TWM2OD1yLkGxOEDDuSByLkCxNUDPxE1?	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR6N{mxO{c,OjV2OEe5NVc9N2F-
MV4-11-ITD/D835V	MlHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYjJR\|UxRTBwMUG2JOKyKDBwMEGxJO69VQ>?	NUXTcIZ3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW0PFc6OTdpPkK1OFg4QTF5PD;hQi=>
MV4-11-ITD/D835V	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFvkPWhKSzVyPUCuNVAzKMLzIECuNFA3KM7:TR?=	M3r6ZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NEi3PVE4Lz5{NUS4O\|kyPzxxYU6=
MV4-11-ITD/F691L	NEn0dXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4rwcmlEPTB;MD6xNVIhyrFiMD6wNVUh\|ryP	M1LSZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NEi3PVE4Lz5{NUS4O\|kyPzxxYU6=
MV4-11-ITD/N841K	MlPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2fic2lEPTB;MD6xNVMhyrFiMD6wNFIh\|ryP	NXjGS4twRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW0PFc6OTdpPkK1OFg4QTF5PD;hQi=>
U937-FLT3 WT	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NIfzOWFKSzVyPUCuNVAzKMLzIECuNFE{KM7:TR?=	Mmr2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2OEe5NVcoRjJ3NEi3PVE4RC:jPh?=
P12-ICHIKAWA	NXHIemdJT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				NV:2NYtDUUN3MDC9JFAvODl4MESg{txO	NFTncYM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
697	NVvK[\|g{T3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				MVfJR\|UxKD1iMD6xOFg{QCEQvF2=	MnviQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
NB69	MVLHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				MX\JR\|UxKD1iMD6xOlE5KM7:TR?=	NHP0bGg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
EoL-1-cell	MoHFS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				MmLoTWM2OCB;IECuNVg4OjZizszN	MmnUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
BHT-101	MWXHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				M3PCXmlEPTBiPTCwMlE6QDJ3IN88US=>	M{[wcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
SK-NEP-1	MlfoS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				MofLTWM2OCB;IECuNlIxODJizszN	M1y2eVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
MHH-NB-11	M{KzcGdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				MofDTWM2OCB;IECuNlIxOTlizszN	NXHXeWh{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
AsPC-1	M2\LNmdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				M37SOmlEPTBiPTCwMlI2OjV\|IN88US=>	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
ES1	M{fpOWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				NGnCeGZKSzVyIE2gNE4zPTZ{NTFOwG0>	MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
LAMA-84	NInDZnhIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				NXXSTFJ4UUN3MDC9JFAvOjV6MUmg{txO	M3WzdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
MOLT-16	M1vRWWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				MmDTTWM2OCB;IECuNlU5PDlizszN	M1f6T\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
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COLO-800	MlrpS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				NYDLUG9oUUN3MDC9JFAvQDl5N{ig{txO	M13vN\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
OVCAR-5	M4W2TWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				NUjiN4w6UUN3MDC9JFAvQTByMTFOwG0>	NX;BTYdwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
LB1047-RCC	Mn7WS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				NVfPTYpnUUN3MDC9JFAvQTJ5NU[g{txO	NIrtOXU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
SW954	MVLHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				NFX5SYlKSzVyIE2gNE46Ojl2MTFOwG0>	M2n5U\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
J-RT3-T3-5	NX7oWnkxT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				MlnRTWM2OCB;IECuPVM3ODZizszN	NYXu[Jk1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
Mewo	M2nEPGdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				M{fnNGlEPTBiPTCwMlk{PjZizszN	NFO0UW89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
NCI-H1770	M4TS[Wdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				M1zQU2lEPTBiPTCwMlk1ODV3IN88US=>	M1e5e\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
HO-1-N-1	M2H4U2dzd3e2aDDJcohq[mm2aX;uJIF{e2G7				M2rh[2lEPTBiPTCwMlk3OjhzIN88US=>	MmT2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
HSC-3	NH\ze\|lIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				MlPrTWM2OCB;IECuPVY3PDhizszN	MoXEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
TYK-nu	MorRS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				MmnJTWM2OCB;IECuPVk5OjVizszN	M2\j[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
KYSE-150	M2[4d2dzd3e2aDDJcohq[mm2aX;uJIF{e2G7				NHLwUYpKSzVyIE2gNU4xODB5NjFOwG0>	M2XWZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
SN12C	NH7nZoNIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				MkniTWM2OCB;IEGuNFA5PzVizszN	Mn;qQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
MOLT-13	Mo\rS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				NGXy[2dKSzVyIE2gNU4xOTR{MTFOwG0>	NFL6UWM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
TE-11	M2D4bWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				Mn24TWM2OCB;IEGuNFQ5OTJizszN	M3juN\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
DB	M1HsW2dzd3e2aDDJcohq[mm2aX;uJIF{e2G7				M2DidGlEPTBiPTCxMlA4Ojd\|IN88US=>	M4iwclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
CAL-39	MYHHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				NWLuUnJGUUN3MDC9JFEvODd3MkKg{txO	M4TaZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
A3-KAW	NWD3elVmT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				MXTJR\|UxKD1iMT6wPFQxQCEQvF2=	NHy2W489[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
CHP-134	NEfob4pIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				NXf2TmdQUUN3MDC9JFEvOTF6MEeg{txO	MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
TGW	M{jjd2dzd3e2aDDJcohq[mm2aX;uJIF{e2G7				M3noOGlEPTBiPTCxMlEzOzl3IN88US=>	NGiweFE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
QIMR-WIL	NFLqPG1Iem:5dHigTY5pcWKrdHnvckBie3OjeR?=				M1HueWlEPTBiPTCxMlE{OTN2IN88US=>	MmSyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
NCI-SNU-1	MmDNS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				MoPpTWM2OCB;IEGuNVY{PTRizszN	NGrOcnk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
CGTH-W-1	NXztR\|BlT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				NEL1OYtKSzVyIE2gNU4yPzF6NjFOwG0>	NFS1TnM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
MHH-ES-1	MWjHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				NX;HWmNWUUN3MDC9JFEvOTd7OE[g{txO	NUnKNZVkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
LB2241-RCC	MkK0S5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				NXPxXYI1UUN3MDC9JFEvOTh4MjFOwG0>	NETnTGg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
ML-2	NISzV2xIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				NEXkdplKSzVyIE2gNU4zODd\|NDFOwG0>	M2HCSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
COR-L23	M4LBbmdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				NGrofJlKSzVyIE2gNU4zOjl\|MzFOwG0>	M1\oT\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
BFTC-905	MmDyS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				MVLJR\|UxKD1iMT6yOFI3PyEQvF2=	M3X3eFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
Hs-578-T	MXrHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				MnrITWM2OCB;IEGuNlU5OTdizszN	NEDrb\|A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
KG-1	MmX4S5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				NE\QPJJKSzVyIE2gNU4zPjZ6NjFOwG0>	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
HEL	Mn\FS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				NEHkTWFKSzVyIE2gNU4zQTN\|ODFOwG0>	NF62Zlg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
A549	M{PsNGdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				MWHJR\|UxKD1iMT6yPVM6QSEQvF2=	NXTJe2JIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
COLO-741	MlTJS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				MoP3TWM2OCB;IEGuN\|IxQDlizszN	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
PC-3	MmjaS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				Mo\HTWM2OCB;IEGuN\|UzOjFizszN	NVzWWnh6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
HOS	NVvkVlhnT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				NWXXXYZXUUN3MDC9JFEvOzV{OU[g{txO	M3TuV\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
HT-1080	NFHBSIJIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				MX3JR\|UxKD1iMT6zO\|UyQSEQvF2=	NYHGOJE{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
TE-8	MULHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				MXrJR\|UxKD1iMT60NVc4PCEQvF2=	MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
BHY	NIGwcXZIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				M2nqU2lEPTBiPTCxMlQ3QTJ\|IN88US=>	M1vQdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
BB65-RCC	MnTzS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				M3i1TGlEPTBiPTCxMlUxPTJ6IN88US=>	MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
HN	NU\6[ZprT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				MXzJR\|UxKD1iMT61OFA4OSEQvF2=	NHfKfmo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
NCI-H441	MX3Hdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				Mn3tTWM2OCB;IEGuOVQ6ODdizszN	MlyyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
RPMI-8866	MXjHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				MV\JR\|UxKD1iMT61PFUxPyEQvF2=	M4fBdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
CAL-62	Mn:0S5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				MX3JR\|UxKD1iMT62NFg3OiEQvF2=	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
MG-63	NVfCVpN4T3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				MYLJR\|UxKD1iMT62NVgyOyEQvF2=	M{\4VVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
SK-LU-1	NEOxUpJIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				Ml\4TWM2OCB;IEGuOlIyPTJizszN	MlvQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
BCPAP	M{G2cGdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				NHvKN5pKSzVyIE2gNU43PjR3NzFOwG0>	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
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CAL-120	M4rLcGdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				NHTm[2tKSzVyIE2gNVMvPjdzODFOwG0>	Mke3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
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A253	MnTZS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				M1f5R2lEPTBiPTCxOU4xPjJ3IN88US=>	M1OxdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
CAL-12T	NG\0XXZIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				NHXlTHlKSzVyIE2gNVUvPDZ4MjFOwG0>	NUHqSmF2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
COLO-679	MlXCS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				Mk\ITWM2OCB;IEG1Mlc3QDNizszN	M{D1OVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
UACC-257	MWTHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				MlTrTWM2OCB;IEG2MlEzODFizszN	NEe2OlE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
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MEL-HO	NV3IN4lLT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				NU\hT3VkUUN3MDC9JFE4Njd3MEOg{txO	Ml[3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
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RCC10RGB	M1L0UWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				M37TN2lEPTBiPTCxPE4yPjl5IN88US=>	MoiwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
HD-MY-Z	MYHHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				NUiwS3V[UUN3MDC9JFE5NjJ{NUSg{txO	M1\6VVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
A427	NEDt[mtIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				M1Gye2lEPTBiPTCxPE42ODl2IN88US=>	NXfNUG1ORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
HCC2998	NGe3c45Iem:5dHigTY5pcWKrdHnvckBie3OjeR?=				MnK4TWM2OCB;IEG4MlYxPTFizszN	NWHrPHRjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
EPLC-272H	NH3hXWVIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				MWXJR\|UxKD1iMUmuNFQ{PCEQvF2=	NXPRWI4{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
C32	M1jON2dzd3e2aDDJcohq[mm2aX;uJIF{e2G7				NI\4eGZKSzVyIE2gNVkvODR3IN88US=>	NIPZZ4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
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CaR-1	M1vKN2dzd3e2aDDJcohq[mm2aX;uJIF{e2G7				NFrHT\|RKSzVyIE2gNVkvPjhyNDFOwG0>	MknEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
KYSE-410	NYfKUJRWT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				NVjURlhKUUN3MDC9JFE6NjlzM{mg{txO	MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
HuCCT1	NUKyOHU6T3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				M2\2[2lEPTBiPTCyNE43Ojl\|IN88US=>	NYLYVFhtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
LB996-RCC	NFfuTGZIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				MVrJR\|UxKD1iMkCuO\|E3QCEQvF2=	M16yZ\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
KYSE-70	NHnC[HBIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				NGLLTIpKSzVyIE2gNlAvQDB3OTFOwG0>	NFvUfpg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
CAL-72	NFTtWpRIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				NIXGNWFKSzVyIE2gNlAvQTF3IN88US=>	NXHZW5lzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
Capan-2	NHjmc2RIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				MWjJR\|UxKD1iMkGuNFQyOyEQvF2=	NYjYXVVsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
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insect cell	NXfUUm5TTnWwY4Tpc44h[XO\|YYm=		MVuyJI1qdnN?		MYrJcohq[mm2aX;uJI9nKEOGS{SvZ5lkdGmwIFSxJEh2dmuwb4fuJI9zcWerbjmg[ZhxemW\|c3XkJIlvKGKjY4Xsc5ZqenW\|IHnu[oVkfGWmIHnud4VkfCClZXzsd{B2e2mwZzDHV3Qu\nW\|ZXSgdHJjKCh5OUKgeI8hQTJ6KTDhd{B{fWK\|dILheIUheHKnaX7jeYJifGWmIH\vdkAzKG2rboOg[o9tdG:5ZXSgZpkhY2ejbX3hMVMzWF1vQWTQJIFl\Gm2aX;uJI1m[XO3cnXkJIFnfGW{IEG1JI1qdnNiYomgZoV1[SCybHH0[UBkd3WwdHnu[{BidmGueYPpd{whUUN3MDC9JFAvODFzIN88UU4>	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjFzNUW3NUc,OjZzMUW1O\|E9N2F-
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insect cell	M{G0UWZ2dmO2aX;uJIF{e2G7		MlLRNkBucW6\|		MVrJcohq[mm2aX;uJI9nKEOGS{[vZ5lkdGmwIFSyJEh2dmuwb4fuJI9zcWerbjmg[ZhxemW\|c3XkJIlvKGKjY4Xsc5ZqenW\|IHnu[oVkfGWmIHnud4VkfCClZXzsd{B2e2mwZzDHV3QufGGpZ3XkJJBTSiBqN{myJJRwKDl{ODDy[ZNq\HWnczmgZZMhe3Wkc4TyZZRmKHC{ZXnuZ5Vj[XSnZDDmc5IhOiCvaX7zJIZwdGyxd3XkJIJ6KFupYX3tZVMzWF2DVGCgZYRlcXSrb36gcYVie3W{ZXSgZYZ1\XJiMUWgcYlveyCkeTDi[ZRiKGOxdX70bY5oKG2ndHjv[EwhUUN3MDC9JFAvODF3IN88UU4>	M{jmN\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUexNFM3Lz5{N{G3NVA{PjxxYU6=
MDA-MB-453	NFnEXlZEgXSxdH;4bYNqfHliYYPzZZk>		NGPMWJQ1QCCqcoO=		Mom2R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUS1N{Bk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgOFghcHK\|IHL5JGNEUzhiYYPzZZktKEmFNUCgQUAxNjF\|NzFOwG0v	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzR2OEmxN{c,Ojd2NEi5NVM9N2F-
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MDA-MB-231	MnnMR5l1d3SxeHnjbZR6KGG\|c3H5		NIjw[5Q1QCCqcoO=		NXmxOVE4S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVI{OSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KEOFS{igZZN{[XluIFnDOVAhRSByLkW4JO69VS5?	Mn\ZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd2NEi5NVMoRjJ5NES4PVE{RC:jPh?=
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A2780	MnrDS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		NXy5N2xqPzJiaILz		Mn6yS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gRVI4QDBiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JJJme2G8dYLpckBweiCPVGSgZZN{[XluIFfJOVAhRSByLkCzNkDPxE1w	NUHpNVRvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkixOVYyOTFpPkK4NVU3OTFzPD;hQi=>
MV4-11	NILPTJRIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		Moq3O\|IhcHK\|		M1PocGdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG1XPC1zMTDj[YxteyCjZoTldkA4OiCqcoOgZpkhemW\|YYr1dolvKGG\|c3H5MEBIUTVyIE2gNE4xPSEQvF2u	MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDF3NkGxNUc,OjhzNU[xNVE9N2F-
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MDA-MB-453	NFHxPXZIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		MmTOO\|IhcHK\|		MXjHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDNSGEuVUJvNEWzJINmdGy\|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFfJOVAhRSByLkOyOkDPxE1w	NVT6ZmlsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkixOVYyOTFpPkK4NVU3OTFzPD;hQi=>
MCF7	NWjhSW8{T3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		MnnrO\|IhcHK\|		Mmn6S5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjC3NkBpenNiYomgdoV{[Xq3cnnuJI9zKE2WVDDhd5NigSxiR1m1NEA:KDBwNUW3JO69VS5?	M4Xk[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUW2NVEyLz5{OEG1OlEyOTxxYU6=
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C4-2B	NGTZSo1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?=		NGO1PI84OiCqcoO=		MkDMS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gR\|QuOkJiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JJJme2G8dYLpckBweiCPVGSgZZN{[XluIFfJOVAhRSB2LkG1JO69VS5?	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDF3NkGxNUc,OjhzNU[xNVE9N2F-
DU145	MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		MWW3NkBpenN?		MlXXS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gSHUyPDViY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JJJme2G8dYLpckBweiCPVGSgZZN{[XluIFfJOVAhRSB3Lke5NkDPxE1w	NUD0NpBtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkixOVYyOTFpPkK4NVU3OTFzPD;hQi=>
MDA-MB-468	MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		NWi5V49qPzJiaILz		MYDHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDNSGEuVUJvNE[4JINmdGy\|IHHmeIVzKDd{IHjyd{BjgSC{ZYPhfpVzcW5ib4KgUXRVKGG\|c3H5MEBIUTVyIE2gOU46PiEQvF2u	M3vWO\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUW2NVEyLz5{OEG1OlEyOTxxYU6=
BPH1	MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		NGDBO4o4OiCqcoO=		M{nu[mdzd3e2aDDpcohq[mm2aX;uJI9nKG6xboTyZY5{\m:{bXXkJIh2dWGwIFLQTFEh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IILld4F7fXKrbjDvdkBOXFRiYYPzZZktKEeLNUCgQUA4NjR2MjFOwG0v	M4CwWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUW2NVEyLz5{OEG1OlEyOTxxYU6=
K562	MWnDfZRwfG:6aXPpeJkh[XO\|YYm=		NFm1cJM6PiCqcoO=		NGLFOHlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMPTZ{IHPlcIx{KGGodHXyJFk3KGi{czDifUBE\WyuLWTpeIVzKEKudXWgZZN{[XluIFnDOVAhRSB{IN88UU4>	M3\LUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEG3OVY3Lz5{NESxO\|U3PjxxYU6=
DU145	MULDfZRwfG:6aXPpeJkh[XO\|YYm=		NFXwN3M6PiCqcoO=		MXjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{Bi\nSncjC5OkBpenNiYomgR4VtdC2WaYTldkBDdHWnIHHzd4F6NCCLQ{WwJF0hPy53IN88UU4>	NFfRNoI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NESxO\|U3Pid-MkS0NVc2PjZ:L3G+
MDA-MB-231	M2nrUGNmdGxiY4njcIUh[XK{ZYP0JIF{e2G7	MnKwNE42KHSxIEGgeW0>	NX7mS\|FCOjRiaILz		NUfVe3JPS2WubDDjfYNt\SCjcoLld5QhcW5iaIXtZY4hVUSDLV3CMVI{OSClZXzsd{Bie3Onc4Pl[EBieyCjY3P1cZVt[XSrb36gZZQhTzFicHjhd4Uh[XRiMD61JJRwKDFidV2gZYZ1\XJiMkSgbJJ{KGK7IIDyc5Bq\Gm3bTDpc4Rq\GVic4ThbY5qdmdvYnHz[YQh\myxdzDjfZRwdWW2cnnjJIFv[Wy7c3nz	NIntVWY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NESxO\|U3Pid-MkS0NVc2PjZ:L3G+
MCF7	NUXT[oFMS2WubDDjfYNt\SCjcoLld5Qh[XO\|YYm=	NFPISFAxNjVidH:gNUB2VQ>?	NVrnWGpjOjRiaILz		NUDoNWJKS2WubDDjfYNt\SCjcoLld5QhcW5iaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDhZ4N2dXWuYYTpc44h[XRiR{GgdIhie2ViYYSgNE42KHSxIEGgeW0h[W[2ZYKgNlQhcHK\|IHL5JJBzd3CrZHn1cUBqd2SrZHWgd5RicW6rbnetZoF{\WRiZnzve{BkgXSxbXX0dolkKGGwYXz5d4l{	MkXiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR2MUe1OlYoRjJ2NEG3OVY3RC:jPh?=
MDA-MB-231	NF70dlBHfW6ldHnvckBie3OjeR?=	MkjYNE42KHSxIEWgeW0>	MlLvNlQhcHK\|		NIXzPHdKdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JGNFUzRxY4njcIlvTDFiaX6gbJVu[W5iTVTBMW1DNTJ\|MTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHKndHnuc4Jt[XO2b33hJJBpd3OyaH;yfYxifGmxbjDheEBU\XJ5OECgZZQhOC53IITvJFUhfU1iYX\0[ZIhOjRiaILzJIJ6KFenc4Tldo4h[myxdITpcoch[W6jbInzbZM>	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDRzN{W2Okc,OjR2MUe1OlY9N2F-
MDA-MB-231	NV7RbmliTnWwY4Tpc44h[XO\|YYm=	Mlz6NE42KHSxIEWgeW0>	NHTtRVYzPCCqcoO=		MmPsTY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDDSGs1N2O7Y3zpcmQyKGmwIHj1cYFvKE2GQT3NRk0zOzFiY3XscJMh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBz\XSrbn;icIF{fG:vYTDwbI9{eGixconsZZRqd25iYYSgV4VzPzhyIHH0JFAvPSC2bzC1JJVOKGGodHXyJFI1KGi{czDifUBY\XO2ZYLuJIJtd3S2aX7nJIFv[Wy7c3nz	M4PYfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEG3OVY3Lz5{NESxO\|U3PjxxYU6=
MCF7	NVn0cVBXTnWwY4Tpc44h[XO\|YYm=	NYr5XYNPOC53IITvJFUhfU1?	NYnHdJg3OjRiaILz		NUfQVG9rUW6qaXLpeIlwdiCxZjDy[YNwdWKrbnHueEBETEt2L3P5Z4xqdkRzIHnuJIh2dWGwIF3DSlch[2WubIOgZZN{\XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjDy[ZRqdm:kbHHzeI9u[SCyaH;zdIhwenmuYYTpc44h[XRiU3XyO\|gxKGG2IECuOUB1dyB3IIXNJIFnfGW{IEK0JIhzeyCkeTDX[ZN1\XKwIHLsc5R1cW6pIHHuZYx6e2m\|	NHnhPVg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NESxO\|U3Pid-MkS0NVc2PjZ:L3G+
MCF7	MnLlSpVv[3Srb36gZZN{[Xl?	NHvhW4YxNjVidH:gOUB2VQ>?	MX6yOEBpenN?		MVLJcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IFPET\|Qw[3mlbHnuSFEhcW5iaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHKndHnuc4Jt[XO2b33hJJBpd3OyaH;yfYxifGmxbjDheEBU\XJ5OECgZZQhOC53IITvJFUhfU1iYX\0[ZIhOjRiaILzJIJ6KFenc4Tldo4h[myxdITpcoch[W6jbInzbZM>	NUDo[5dCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS0NVc2PjZpPkK0OFE4PTZ4PD;hQi=>
MV4-11	NH63OXVHfW6ldHnvckBie3OjeR?=		MnvwNVIhfG9iMkSgbJJ{		Ml22TY5pcWKrdHnvckBw\iCFRFu0M\|YhcW5iaIXtZY4hVVZ2LUGxJINmdGy\|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiCUYjDwbI9{eGixconsZZRqd25iYYSgV4VzPzhyIHH0JGdKPTBiYX\0[ZIhOTJidH:gNlQhcHK\|IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>?	M3XPUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUW2NVEyLz5{OEG1OlEyOTxxYU6=
MV4-11	MVnGeY5kfGmxbjDhd5NigQ>?		MoDJNVIhfG9iMkSgbJJ{		NIX6VYFKdmirYnn0bY9vKG:oIFPET\|QwPiCrbjDoeY1idiCPVkStNVEh[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIGLiJJBpd3OyaH;yfYxifGmxbjDheEBU\XJ5OECgZZQhT0l3MDDh[pRmeiBzMjD0c{AzPCCqcoOgZpkhX2W\|dHXyckBjdG:2IHHuZYx6e2m\|	Mln5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhzNU[xNVEoRjJ6MUW2NVEyRC:jPh?=
A673	M{XvS5FJXFNiYYPzZZk>				NXnP[XZ7eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IFG2O\|Mh[2WubIO=	MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
Saos-2	NVK5TmtjeUiWUzDhd5NigQ>?				NHjrPWxyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiU3Hvd{0zKGOnbHzz	NHz5[Wk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
BT-37	MkX3dWhVWyCjc4PhfS=>				MXjxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhSlRvM{egZ4VtdHN?	MoWwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
RD	M13mc5FJXFNiYYPzZZk>				NHTUbWtyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiUlSgZ4VtdHN?	MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
SK-N-SH	MnnodWhVWyCjc4PhfS=>				MW\xTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhW0tvTj3TTEBk\Wyucx?=	NHTNOXo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
NB1643	M1Pye5FJXFNiYYPzZZk>				NX7ROmVmeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IF7CNVY1OyClZXzsdy=>	M4TiUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
OHS-50	MoHMdWhVWyCjc4PhfS=>				NHXDT\|RyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiT1jTMVUxKGOnbHzz	NHjZfZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
SK-N-MC	M4\RPJFJXFNiYYPzZZk>				M4TjUpFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCVSz3OMW1EKGOnbHzz	MoCwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
NB-EBc1	NUDDNHNteUiWUzDhd5NigQ>?				M{LQd5FJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCQQj3FRoMyKGOnbHzz	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
LAN-5	M1L2ZpFJXFNiYYPzZZk>				MWrxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhVEGQLUWgZ4VtdHN?	NF7Yfpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
Rh18	MmjEdWhVWyCjc4PhfS=>				M4fvdpFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCUaEG4JINmdGy\|	MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	RB1 (pT821) / RB1 (pS780); PubMed: 30300583 Cancer cell Immunoblots showing dose-dependent impact of 72 hr palbociclib treatment on indicated protein levels in Kasumi-1 and SKNO-1 cells. pAMPKα(T172) / AMPKα; PubMed: 28453226 Mol Oncol Dose-dependent response of palbociclib on AMPK‐related molecules. HCC cells were treated with different concentrations of palbociclib for 24 h. The phosphorylation of the indicated proteins was determined by western blotting. pULK1(S317) / ULK1; PubMed: 28453226 Mol Oncol Dose-dependent response of palbociclib on AMPK‐related molecules. HCC cells were treated with different concentrations of palbociclib for 24 h. The phosphorylation of the indicated proteins was determined by western blotting. c-Jun / p-c-Jun / NFκB(p50); PubMed: 26540629 Oncotarget The expression of c-Jun and phosphorylated c-Jun was assessed using western blot after the cells were treated with palbociclib. p38 / p-P38 / JNK / p-JNK; PubMed: 26540629 Oncotarget MAPK pathway-related proteins, p38, ERK, JNK expression levels were detected.	30300583 28453226 26540629
Growth inhibition assay	Cell viability; PubMed: 28453226 Mol Oncol Dose- and time-dependent effects of palbociclib on cell viability in three HCC cell lines. Hep3B, Huh7, and PLC5 cells were treated with palbociclib at the indicated concentrations for 24 or 48 h and assayed by MTT. The solvent (DMSO) concentration in each sample is equal (0.7%). IC50; PubMed: 27099147 Blood Dose-response curve of ITD+ (red) or control (black) leukemic cells with CDK4/6 inhibitor palbociclib. Cells were incubated with increasing concentrations for 72 hours. Cell viability and proliferation were assessed by using the CTG assay. IC50 values were calculated by using GraphPad Prism software. Error bars indicate ± SEM.	28453226 27099147
Immunofluorescence	γH2AX(Ser139); PubMed: 29669860 EMBO J Representative maximum‐intensity projections of MCF7 cells treated with the 1 μM palbociclib and/or 7.5 nM bortezomib. Note that 7.5 nM bortezomib inhibits proteasome only partially. Fixed and permeabilized cells were stained with Alexa Fluor 488‐conjugated Ki67 antibody, Alexa Fluor 647‐conjugated phospho‐Histone H2A.X (γH2AX) (pSer139) antibody, and DAPI. All images were acquired with the same magnification, and scale bar is 20 μm. LC3B; PubMed: 28453226 Mol Oncol LC3B immunofluorescence in palbociclib‐treated Hep3B cells. Arrowheads indicate LC3‐positive autophagosomes. Nuclei were counterstained with DAPI (blue).	29669860 28453226
ELISA	PGE2; PubMed: 26540629 Oncotarget The supernatant of control and 7.5 μM palbociclib-treated cells was collected and stored at −80°C. PGE2 secretion was detected using ELISA.	26540629

体内研究

PD 0332991(150 mg/kg)作用于Colo-205结肠癌移植瘤，诱导肿瘤快速衰退，肿瘤生长相应延迟。PD 0332991(150 mg/kg)作用于MDA-MB-435乳腺癌，诱导全部肿瘤停滞和杀死细胞。PD 0332991(150 mg/kg)处理携带SF-295胶质母细胞瘤，和ZR-75-1乳腺癌和PC-3前列腺肿瘤模型(完全抑制肿瘤生长)的小鼠，显著诱导肿瘤衰退。PD 0332991 (150 mg/kg)处理 MDA-MB-435乳腺癌超过24小时，抑制Rb在Ser⁷⁸⁰位点磷酸化。PD 0332991(150 mg/kg)处理Colo-205 移植瘤，下调四种E2F调节的基因CDC2, CCNE2, TK1, 和 TOP2A表达。^[1]PD 0332991也快速抑制骨髓瘤生长。^[2]

激酶实验：^[4]	- 合并 CDK活性实验: 在96孔过滤板中进行动力学测评，测定CDK实验的IC50值。所有的CDK-cyclin激酶复合物在昆虫细胞中通过杆状病毒感染而表达，并进行纯化。实验底物是与GST(GST•RB-Cterm)融合的pRb组分(792–928位氨基酸)。总反应体积为0.1 mL，包含终浓度20 mM Tris-HCl,pH 7.4, 50 mM NaCl,1 mM 二硫苏糖醇,10 mM MgCl₂，含0.25 μCi[γ-³²P]ATP的25 μM ATP(作用于 CDK4-cyclin D1, CDK6-cyclin D2, 和 CDK6-cyclin D3), 20 ng 酶, 1 μg GST•RB-Cterm, 及适度稀释的抑制剂。每孔加入全部组分，除了[γ-³²P]ATP，置于混合器中2分钟。加入[γ-³²P]ATP开始反应,在25°C下温育15分钟。加入0.1 mL 20% 三氯乙酸终止反应, 实验板置于4°C至少1小时，使底物沉淀。每孔使用 0.2 mL 10%三氯乙酸洗涤五次，使用β计数器测定渗透的放射性。
细胞实验：^[3]	- 合并 Cell lines: 人类乳腺癌细胞MDA-MB-435 Concentrations: 2 μM Incubation Time: 6 天 Method: 细胞按一式两份每孔5,000 到10,000个细胞接种在24孔板中，接种后，加入不同浓度的PD 0332991。对照组不加入药物。温育末期，细胞胰蛋白酶化，并置于等渗溶液中，并立即使用Coulter Z2粒子计数器计数。 (Only for Reference)
动物实验：^[1]	- 合并 Animal Models: 人类结肠癌移植瘤Colo-205 Dosages: 150 mg/kg Administration: 每天口服处理 (Only for Reference)

参考文献

[4] Fry DW, et al. J Biol Chem, 2001, 276(20), 16617-16623.

- 合并

溶解度 (25°C)

体外	Water	10 mg/mL warmed (17.43 mM)
	DMSO	Insoluble
	Ethanol	Insoluble
体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： saline (with warming)	10mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download Palbociclib (PD0332991) Isethionate SDF

分子量	573.66
化学式	C₂₄H₂₉N₇O₂.C₂H₆O₄S
CAS号	827022-33-3
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	N/A

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

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