Palbociclib (PD0332991) Isethionate

For research use only. Not for use in humans.

Pfizer辉瑞授权生产目录号：S1579

Palbociclib (PD0332991) Isethionate Chemical Structure

CAS No. 827022-33-3

Palbociclib (PD0332991) Isethionate是一种高度选择性的CDK4/6抑制剂，无细胞试验中IC50为11 nM/16 nM，对CDK1/2/5，EGFR，FGFR，PDGFR， InsR等没有抑制活性。Phase 3。

规格

价格

库存

购买数量

10mg	RMB 1217.51	现货
25mg	RMB 2189.47	现货
50mg	RMB 3026.06	现货
200mg	RMB 8763.3	现货
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客户使用Selleck生产的Palbociclib (PD0332991) Isethionate发表文献219篇：

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Cell Cycle, 2016, 15(20):2742-52

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Biochemistry, 2016, 55(38):5434-41

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BMC Syst Biol, 2016, 10(1):73

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Oncotarget, 2016,

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Blood, 2015, 24;126(13):1565-74

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J Natl Cancer Inst, 2015, 108(6):djv406

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Sci Rep, 2015, 5:14391

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Cancer Med, 2015, 4(9):1417-25

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Anticancer Res, 2015,

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Blood, 2014, 3;124(1):13-23

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Proc Natl Acad Sci U S A, 2014, 111(26):9503-8

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Cancer Res, 2014, 74(6):1739-51

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Oncotarget, 2014,

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Nucleic Acids Res, 2013, 41(22):10334-44

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Cell Death Dis, 2013, 4:e973

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Carcinogenesis, 2013, 34(10):2244-52

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Neoplasia, 2013, 15(8):939-51

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J Virol, 2013, 87(8):4623-41

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Cell Cycle, 2013, 12(23):3689-701

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Cell Cycle, 2013, 12(18):3063-9

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PLoS One, 2013, 8(11):e78641

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Clin Cancer Res, 2012, 18(17):4612-20

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Cancer Prev Res (Phila), 2012, 5(6):810-21

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FEBS J, 2012, 279(18):3290-313

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Clin Cancer Res, 2011, 1;17(13):4513-22

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产品安全说明书

CDK抑制剂选择性比较

生物活性

产品描述

特性

PD 0332991治疗多种癌症，特异性抑制CDK4/6，是第一种有前途的抑制剂。

靶点

CDK4/CyclinD3 ^[1] (Cell-free assay)	CDK4/CyclinD1 ^[1] (Cell-free assay)	CDK6/CyclinD2 ^[1] (Cell-free assay)
9 nM	11 nM	15 nM

体外研究

PD 0332991对CDK4/6具有绝对选择性，对其他CDKs几乎没有抑制活性。PD 0332991作用于MDA-MB-435乳腺癌细胞，有效降低Rb在Ser780 和 Ser795位点磷酸化，IC50分别为66 nM和63 nM。PD 0332991通过抑制细胞进入S期，有效抑制细胞生长，抑制 DNA复制。PD 0332991抑制胸苷渗透进Rb阳性人类乳腺癌(如MDA-MB-435, MCF-7), 结肠癌 (H1299), 和肺癌(Colo-205) 及白血病(CRRF-CEM和K562)的DNA中，IC50值为0.04-0.17 μM。PD 0332991显著增强MDA-MB-453在G1期的百分比。^[1]PD 0332991作用于CD138⁺原发性骨髓瘤细胞，初级非转化的B细胞，MM1.S和CAG HMCLs细胞系，抑制Rb磷酸化，IC50分别为 <0.1 μM, 0.05 μM, 和 60-70 nM。PD 0332991作用于CD138⁺原发性骨髓瘤细胞和初级非转化的B细胞，诱导细胞停滞在G1期。PD 0332991诱导MM1.S细胞停滞在G1期，IC50为~0.05 μM。^[2]PD 0332991优先抑制Luminal雌激素受体阳性(包括HER2阳性)人类乳腺癌细胞系。PD 0332991作用于大部分敏感的细胞系，促进pRb和cyclin D1基因表达，且降低CDKN2A(p16)基因表达。PD 0332991作用于条件性抗ER抑制的细胞系，增强对Tamoxifen的敏感性。^[3]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
H157	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGfvWIoxNTFyMDFOwG0>	MVe3NkBp		M2\0cmlEPTB;OTFOwG0>	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjN7MEO0Nkc,OjZ\|OUCzOFI9N2F-
H2170	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGDJbIgxNTFyMDFOwG0>	MojRO\|IhcA>?		NXPsPHRwUUN3ME21JO69VQ>?	NFL1V5o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkO5NFM1Oid-Mk[zPVA{PDJ:L3G+
H520	NYHZVWxwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGXlXGkxNTFyMDFOwG0>	MUW3NkBp		M1rPUWlEPTB;MD63N{DPxE1?	M4rpXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4M{mwN\|QzLz5{NkO5NFM1OjxxYU6=
H596	MmHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Ml[zNE0yODBizszN	NHvy[YU4OiCq		NFXL[VdKSzVyPUGyJO69VQ>?	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjN7MEO0Nkc,OjZ\|OUCzOFI9N2F-
IMR-32	NUXqSWwyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NYDw[IJ6PDkEoHi=	NVvXfmI1TE2VTx?=	MUfJR\|UxRTJ4MTDuUS=>	M3;wWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MkK1NVI{Lz5{NkKyOVEzOzxxYU6=
SH-SY5Y	M2jWO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MXS0POKhcA>?	MXPEUXNQ	NVXXOlQ6UUN3ME22O\|Yhdk1?	MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ{NUGyN{c,OjZ{MkWxNlM9N2F-
NGP	NWTWelE3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		M4PYcFQ5yqCq	MVXEUXNQ	MYTJR\|UxRTJwMEe3JO69VQ>?	M1XT[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MkK1NVI{Lz5{NkKyOVEzOzxxYU6=
SH-EP	NWPnVVlpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MoXCOFjDqGh?	MYXEUXNQ	MUTJR\|UxRTJwMkGxJO69VQ>?	NG\Ke3I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkKyOVEzOyd-Mk[yNlUyOjN:L3G+
IMR-32	M33wRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mn3WNUDPxE1?	MkjPNlQhcA>?	NEnwbYRFVVOR	M{XqVYlv\HWlZYOgS\|Eh[XK{ZYP0	MlXoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ{MkWxNlMoRjJ4MkK1NVI{RC:jPh?=
SH-SY5Y	MmPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUTaboxLOSEQvF2=	Mly2NlQhcA>?	MmnSSG1UVw>?	M37hW4lv\HWlZYOgS\|Eh[XK{ZYP0	M2n3UFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MkK1NVI{Lz5{NkKyOVEzOzxxYU6=
NGP	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXSxJO69VQ>?	NUPidpBsOjRiaB?=	M2jObmROW09?	NYDCRVlRcW6mdXPld{BIOSCjcoLld5Q>	MoHRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ{MkWxNlMoRjJ4MkK1NVI{RC:jPh?=
SH-EP	M1TQdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXTjSnY3OSEQvF2=	MWqyOEBp	MYrEUXNQ	MXLpcoR2[2W\|IFexJIFzemW\|dB?=	NWTWeXV2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[yNlUyOjNpPkK2NlI2OTJ\|PD;hQi=>
NGP	MVzGeYN1cW:wIFHzd4F6	MVWwMVEh\|ryP	MljENlQhcA>?	MlLYSG1UVw>?	NInmS2xz\WS3Y3XzJJRp\SCneIDy[ZN{cW:wIH;mxsBVV1B{QT\|CpGNEVkV{LDDhcoTDqFSNMdMgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK=	NIH3eJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkKyOVEzOyd-Mk[yNlUyOjN:L3G+
IMR-32	MU\GeYN1cW:wIFHzd4F6	MWqwMVEh\|ryP	NVzxSYxLOjRiaB?=	NHu1bopFVVOR	NVfBWXBremWmdXPld{B1cGViZYjwdoV{e2mxbjDv[uKhXE:SMlGsxsBES06HMjygZY5lyqCWS{JCpIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy	M4DFe\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MkK1NVI{Lz5{NkKyOVEzOzxxYU6=
U-CH2	NXLUSGpMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4\HdlAuOSEQvF2=	MX23NkBp		Mn;hTWM2OD13MD6yJI5O	NInaV249[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkG4N\|kzPSd-Mk[xPFM6OjV:L3G+
U-CH3	Mo\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUCwMVEh\|ryP	MnfkO\|IhcA>?		NXHTZ5NnUUN3ME21NkBvVQ>?	M3fXdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MUizPVI2Lz5{NkG4N\|kzPTxxYU6=
U-CH6	M2jWVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmSxNE0yKM7:TR?=	NXvrV\|VjPzJiaB?=		NVrNT\|liUUN3ME25NEBvVQ>?	NH3hblM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkG4N\|kzPSd-Mk[xPFM6OjV:L3G+
U-CH7	NVf6dHZPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWfDR2x6OC1zIN88US=>	NXvKbYpCPzJiaB?=		M{jzb2lEPTB;OUigcm0>	NXzMeoZDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xPFM6OjVpPkK2NVg{QTJ3PD;hQi=>
U-CH11	NVPpWVloT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXTHeYR4OC1zIN88US=>	MWe3NkBp		M4XOWGlEPTB;M{SwJI5O	M4r0V\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MUizPVI2Lz5{NkG4N\|kzPTxxYU6=
MCF7	M4TDXWZ2[3Srb36gRZN{[Xl?	MnrZNk42NTJ3MDDuUS=>	MnjENlQhcA>?		NV65d3pzemWmdXPld{BT[iCyaH;zdIhwenmuYYTpc44>	M2TaXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUmxPFE4Lz5{NUm5NVgyPzxxYU6=
MV4-11	M37RcGFxd3C2b4Ppd{BCe3OjeR?=	MVewMlUh\|ryP	MorKNlQhcA>?		NXX4c45s\W6qYX7j[ZMh[XCxcITvd4l{KGmwZIXj[YQh[nlic3;yZYZmdmmkIHHu[EBCSzJ{MB?=	NEnVcWo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUS4O\|kyPyd-MkW0PFc6OTd:L3G+
MOLM13	NHrrNldCeG:ydH;zbZMhSXO\|YYm=	NETqPFAxNjVizszN	MUmyOEBp		M{PyN4VvcGGwY3XzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KHOxcnHm[Y5q[iCjbnSgRWMzOjB?	MnThQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2OEe5NVcoRjJ3NEi3PVE4RC:jPh?=
MOLM13-ITD alone	NUH5bVVwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NFmySW9KSzVyPUCuNFg6KMLzIECuNFA6KM7:TR?=	M3\tRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NEi3PVE4Lz5{NUS4O\|kyPzxxYU6=
MV4-11-ITD alone	M2r2PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NXnwU3ZVUUN3ME2wMlA6OiEEsTCwMlAxQCEQvF2=	NX3mUI97RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW0PFc6OTdpPkK1OFg4QTF5PD;hQi=>
MOLM13-ITD/D835Y	NVvENZJJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MmPETWM2OD1yLkGxOEDDuSByLkCxNUDPxE1?	M{mzWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NEi3PVE4Lz5{NUS4O\|kyPzxxYU6=
MV4-11-ITD/D835V	NGLJXWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWCzXWszUUN3ME2wMlEyPiEEsTCwMlAyOSEQvF2=	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR6N{mxO{c,OjV2OEe5NVc9N2F-
MV4-11-ITD/D835V	NEm1NZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXPJR\|UxRTBwMUCyJOKyKDBwMEC2JO69VQ>?	NEnvUFg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUS4O\|kyPyd-MkW0PFc6OTd:L3G+
MV4-11-ITD/F691L	M4\EZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NYPyV4tOUUN3ME2wMlEyOiEEsTCwMlAyPSEQvF2=	NV3YRpZTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW0PFc6OTdpPkK1OFg4QTF5PD;hQi=>
MV4-11-ITD/N841K	M1\yRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHu0O2xKSzVyPUCuNVE{KMLzIECuNFAzKM7:TR?=	NFjaZW49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUS4O\|kyPyd-MkW0PFc6OTd:L3G+
U937-FLT3 WT	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NYrGbZA4UUN3ME2wMlExOiEEsTCwMlAyOyEQvF2=	M4LSb\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NEi3PVE4Lz5{NUS4O\|kyPzxxYU6=
P12-ICHIKAWA	M4exeWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				M3faOmlEPTBiPTCwMlA6PjB2IN88US=>	NYHQcHBLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
697	NUi0R\|NsT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				M2m0dWlEPTBiPTCwMlE1QDN6IN88US=>	Mn;GQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
NB69	MYfHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				NEHkVoVKSzVyIE2gNE4yPjF6IN88US=>	NIXEUW49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
EoL-1-cell	M4jvRmdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				Ml7XTWM2OCB;IECuNVg4OjZizszN	MnT2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
BHT-101	MVfHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				MXfJR\|UxKD1iMD6xPVgzPSEQvF2=	NGraPIk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
SK-NEP-1	NFjCT\|dIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				M1qwNGlEPTBiPTCwMlIzODB{IN88US=>	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
MHH-NB-11	NWHoOFVST3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				MXnJR\|UxKD1iMD6yNlAyQSEQvF2=	NILtc4o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
AsPC-1	NFzQVG9Iem:5dHigTY5pcWKrdHnvckBie3OjeR?=				NGPLXWpKSzVyIE2gNE4zPTJ3MzFOwG0>	NXrvNXgxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
ES1	NH:3W21Iem:5dHigTY5pcWKrdHnvckBie3OjeR?=				MoXXTWM2OCB;IECuNlU3OjVizszN	Mn2zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
LAMA-84	Mo\lS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				MnnkTWM2OCB;IECuNlU5OTlizszN	M4LIOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
MOLT-16	NHLrcoJIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				NWHhdWppUUN3MDC9JFAvOjV6NEmg{txO	NWO1TGVbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
ES7	NGfCZWJIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				NFizZWVKSzVyIE2gNE4zPzNyOTFOwG0>	NVnHWGJ[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
KY821	MnywS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				NWXIeHFpUUN3MDC9JFAvOzF2MTFOwG0>	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
RT-112	NUjnWFRkT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				NHz2codKSzVyIE2gNE4{OjFyNTFOwG0>	NVntfXBjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
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LB1047-RCC	MUDHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				NUnEbXNyUUN3MDC9JFAvQTJ5NU[g{txO	MmH0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
SW954	MVrHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				M3HBNGlEPTBiPTCwMlkzQTRzIN88US=>	MnTRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
J-RT3-T3-5	NXT0e25oT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				MXfJR\|UxKD1iMD65N\|YxPiEQvF2=	MoLDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
Mewo	MWDHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				Moe4TWM2OCB;IECuPVM3PiEQvF2=	NGfkOI49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
NCI-H1770	NXjWblFpT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				MnrBTWM2OCB;IECuPVQxPTVizszN	MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
HO-1-N-1	MUTHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				MXrJR\|UxKD1iMD65OlI5OSEQvF2=	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
HSC-3	NEi3SZpIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				MknLTWM2OCB;IECuPVY3PDhizszN	M4DVR\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
TYK-nu	MW\Hdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				MnjyTWM2OCB;IECuPVk5OjVizszN	NEHzeZo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
KYSE-150	MX;Hdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				NH\BSIFKSzVyIE2gNU4xODB5NjFOwG0>	M1vLOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
SN12C	NUf0R\|ZkT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				NVfVVXc6UUN3MDC9JFEvODB6N{Wg{txO	M4PvcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
MOLT-13	MnTKS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				MorSTWM2OCB;IEGuNFE1OjFizszN	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
TE-11	NHj0WYNIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				NV;SelRQUUN3MDC9JFEvODR6MUKg{txO	M4G3RVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
DB	M3[0[mdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				MYjJR\|UxKD1iMT6wO\|I4OyEQvF2=	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
CAL-39	MVrHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				MVzJR\|UxKD1iMT6wO\|UzOiEQvF2=	NGHmb2o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
A3-KAW	MofFS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				NX3ISlR[UUN3MDC9JFEvODh2MEig{txO	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
CHP-134	MkHPS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				NEK1dGpKSzVyIE2gNU4yOThyNzFOwG0>	MofUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
TGW	M4fCXWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				MUDJR\|UxKD1iMT6xNlM6PSEQvF2=	MkHCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
QIMR-WIL	NFz0Um1Iem:5dHigTY5pcWKrdHnvckBie3OjeR?=				NVyzS2M6UUN3MDC9JFEvOTNzM{Sg{txO	NIPFT5E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
NCI-SNU-1	M{XwN2dzd3e2aDDJcohq[mm2aX;uJIF{e2G7				MoWxTWM2OCB;IEGuNVY{PTRizszN	NHXpVmY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
CGTH-W-1	MmXES5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				NIPZZmZKSzVyIE2gNU4yPzF6NjFOwG0>	M4PZfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
MHH-ES-1	NHLPTHRIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				MojkTWM2OCB;IEGuNVc6QDZizszN	NFTUSZc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
LB2241-RCC	Ml3MS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				NV7BTFRtUUN3MDC9JFEvOTh4MjFOwG0>	M3;tVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
ML-2	MYrHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				NVrYS\|JNUUN3MDC9JFEvOjB5M{Sg{txO	MkjoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
COR-L23	NFnjOldIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				NVyzUW9mUUN3MDC9JFEvOjJ7M{Og{txO	NVzoOFhsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
BFTC-905	NYexNIJ{T3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				MonJTWM2OCB;IEGuNlQzPjdizszN	NX7LZWVTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
Hs-578-T	MXLHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				M2SzO2lEPTBiPTCxMlI2QDF5IN88US=>	NHPmcIE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
KG-1	M{\sfGdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				NIG2Z\|RKSzVyIE2gNU4zPjZ6NjFOwG0>	NHzybW09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
HEL	NFnM[pVIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				NWLBOHNHUUN3MDC9JFEvOjl\|M{ig{txO	NXTadVZuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
A549	M1rVTWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				MXHJR\|UxKD1iMT6yPVM6QSEQvF2=	NHW4Voc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
COLO-741	M{\vbmdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				NIKxRVFKSzVyIE2gNU4{OjB6OTFOwG0>	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
PC-3	MoLNS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				NV3nd3N{UUN3MDC9JFEvOzV{MkGg{txO	NYK2WGtLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
HOS	MlT1S5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				MXTJR\|UxKD1iMT6zOVI6PiEQvF2=	NEjvNow9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
HT-1080	M1TtTGdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				MVrJR\|UxKD1iMT6zO\|UyQSEQvF2=	Mn7vQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
TE-8	Mmn5S5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				MoHLTWM2OCB;IEGuOFE4PzRizszN	NHv1Z409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
BHY	NX;UZ3dJT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				M2K4cWlEPTBiPTCxMlQ3QTJ\|IN88US=>	NVz3[HlpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
BB65-RCC	MXjHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				M2LDPWlEPTBiPTCxMlUxPTJ6IN88US=>	NHjnc2g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
HN	NWrzVFA3T3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				NWjwZVVNUUN3MDC9JFEvPTRyN{Gg{txO	NWjWZ5ZERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
NCI-H441	M1;FbGdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				MX3JR\|UxKD1iMT61OFkxPyEQvF2=	MnTuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
RPMI-8866	MUTHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				MWXJR\|UxKD1iMT61PFUxPyEQvF2=	NUC4WpZNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
CAL-62	NUPFNmJFT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				NXX5emdoUUN3MDC9JFEvPjB6NkKg{txO	NEDyUIU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
MG-63	MlPOS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				MkfaTWM2OCB;IEGuOlE5OTNizszN	M1jDcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
SK-LU-1	M{fSSGdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				M2TnT2lEPTBiPTCxMlYzOTV{IN88US=>	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
BCPAP	M{fnU2dzd3e2aDDJcohq[mm2aX;uJIF{e2G7				MUXJR\|UxKD1iMT62OlQ2PyEQvF2=	NWLkfpZ{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
22RV1	M2j2PGdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				NHrUU\|BKSzVyIE2gNU43Pzh2MzFOwG0>	NEGyS3E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
T47D	MX\Hdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				Mlz2TWM2OCB;IEGuOlgxPjFizszN	M1S4W\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
MSTO-211H	NYfMUVBVT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				NIrtZ4VKSzVyIE2gNU43QTZyMzFOwG0>	NITLOlg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
DEL	MWLHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				NGPyWWVKSzVyIE2gNU44ODJ5MzFOwG0>	MkLMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
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KYSE-140	M1;QNmdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				NEnzUHNKSzVyIE2gNVQvPjN{NzFOwG0>	NFvYNos9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
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CAL-12T	M1\yS2dzd3e2aDDJcohq[mm2aX;uJIF{e2G7				MWnJR\|UxKD1iMUWuOFY3OiEQvF2=	NIS3cZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
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RCC10RGB	NGfMXJBIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				M4nNOWlEPTBiPTCxPE4yPjl5IN88US=>	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
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EPLC-272H	NXXVSIV6T3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				M3zpVGlEPTBiPTCxPU4xPDN2IN88US=>	MmHJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
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KYSE-410	M3fifWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				MmfVTWM2OCB;IEG5MlkyOzlizszN	M{XjclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
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LB996-RCC	NFSxN5FIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				NHL5cVVKSzVyIE2gNlAvPzF4ODFOwG0>	MnvrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
KYSE-70	NHzK[\|NIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				NHzkXoNKSzVyIE2gNlAvQDB3OTFOwG0>	NYfEVZl2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
CAL-72	MmfkS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				MoXjTWM2OCB;IEKwMlkyPSEQvF2=	Mn7PQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
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SBC-1	NXLOPI9LT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				Mkn5TWM2OCB;IEKxMlMxQDFizszN	NHjXZWs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
MFM-223	MoHoS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				M{\yemlEPTBiPTCyNU4{OzR{IN88US=>	NYTOXmN[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
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insect cell	MlvNSpVv[3Srb36gZZN{[Xl?		MUSyJI1qdnN?		MmjXTY5pcWKrdHnvckBw\iCFRFu0M4N6[2yrbjDENUApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCkYXP1cI93cXK3czDpcoZm[3SnZDDpcpNm[3RiY3XscJMhfXOrbnegS3NVNW[3c3XkJJBT[iBqN{myJJRwKDl{ODmgZZMhe3Wkc4TyZZRmKHC{ZXnuZ5Vj[XSnZDDmc5IhOiCvaX7zJIZwdGyxd3XkJIJ6KFupYX3tZU0{OlCfLVHUVEBi\GSrdHnvckBu\WG\|dYLl[EBi\nSncjCxOUBucW6\|IHL5JIJmfGFicHzheIUh[2:3boTpcoch[W6jbInzbZMtKEmFNUCgQUAxNjBzMTFOwG0v	NHXMdpg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkGxOVU4OSd-Mk[xNVU2PzF:L3G+
insect cell	NVjTOG0yTnWwY4Tpc44h[XO\|YYm=		MmWyNkBucW6\|		MonhTY5pcWKrdHnvckBw\iCFRFu0M4N6[2yrbjDENUApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCkYXP1cI93cXK3czDpcoZm[3SnZDDpcpNm[3RiY3XscJMhfXOrbnegS3NVNW[3c3XkJJBT[iBqN{myJJRwKDl{ODmgZZMhe3Wkc4TyZZRmKHC{ZXnuZ5Vj[XSnZDDmc5IhOiCvaX7zJIZwdGyxd3XkJIJ6KFupYX3tZU0{OlCfLVHUVEBi\GSrdHnvckBu\WG\|dYLl[EBi\nSncjCxOUBucW6\|IHL5JIJmfGFicHzheIUh[2:3boTpcoch[W6jbInzbZMtKEmFNUCgQUAxNjBzMTFOwG0v	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjFzNUW3NUc,OjZzMUW1O\|E9N2F-
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insect cell	NV7a[IRPTnWwY4Tpc44h[XO\|YYm=		MVKyJI1qdnN?		M3PjU2lvcGmkaYTpc44hd2ZiQ1TLOE9kgWOuaX6gSFEhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5iYnHjeYxwfmm{dYOgbY5n\WO2ZXSgbY5{\WO2IHPlcIx{KHW\|aX7nJGdUXC22YXfn[YQheFKEIDi3PVIhfG9iOUK4JJJme2mmdXXzLUBieyC\|dXLzeJJifGVicILlbY5kfWKjdHXkJIZweiB{IH3pcpMh\m:ubH;3[YQh[nliW3fhcY1iOzKSXVHUVEBi\GSrdHnvckBu\WG\|dYLl[EBi\nSncjCxOUBucW6\|IHL5JIJmfGFiY3;1cpRqdmdibXX0bI9lNCCLQ{WwJF0hOC5yMUGg{txONg>?	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzF5MUCzOkc,OjdzN{GwN\|Y9N2F-
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insect cell	MnTtSpVv[3Srb36gZZN{[Xl?		M4HBfVIhdWmwcx?=		MlTUTY5pcWKrdHnvckBw\iCFRFu2M4N6[2yrbjDENkApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCkYXP1cI93cXK3czDpcoZm[3SnZDDpcpNm[3RiY3XscJMhfXOrbnegS3NVNXSjZ3fl[EBxWkJiKEe5NkB1dyB7MkigdoV{cWS3ZYOpJIF{KHO3YoP0doF1\SCycnXpcoN2[mG2ZXSg[o9zKDJibXnud{Bnd2yub4fl[EBjgSCdZ3HtcYE{OlCfQWTQJIFl\Gm2aX;uJI1m[XO3cnXkJIFnfGW{IEG1JI1qdnNiYomgZoV1[SClb4XueIlv\yCvZYToc4QtKEmFNUCgQUAxNjBzNTFOwG0v	M2rPV\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUexNFM3Lz5{N{G3NVA{PjxxYU6=
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MDA-MB-453	NVXYZm5tS3m2b4TvfIlkcXS7IHHzd4F6		NYrGR3dmPDhiaILz		MX7DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvNEWzJINmdGy\|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgR2NMQCCjc4PhfUwhUUN3MDC9JFAvOTN5IN88UU4>	M4DoXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NES4PVE{Lz5{N{S0PFkyOzxxYU6=
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MDA-MB-231	M3;kUGN6fG:2b4jpZ4l1gSCjc4PhfS=>		MnXmOFghcHK\|		NIOwUoZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhS0ONODDhd5NigSxiSVO1NEA:KDBwNUig{txONg>?	M3fV[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NES4PVE{Lz5{N{S0PFkyOzxxYU6=
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A2780	M2HrdWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		M{DRPVczKGi{cx?=		MXvHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDBNlc5OCClZXzsd{Bi\nSncjC3NkBpenNiYomgdoV{[Xq3cnnuJI9zKE2WVDDhd5NigSxiR1m1NEA:KDBwMEOyJO69VS5?	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDF3NkGxNUc,OjhzNU[xNVE9N2F-
MV4-11	M{TRfGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		MX23NkBpenN?		M1\Pb2dzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG1XPC1zMTDj[YxteyCjZoTldkA4OiCqcoOgZpkhemW\|YYr1dolvKGG\|c3H5MEBIUTVyIE2gNE4xPSEQvF2u	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDF3NkGxNUc,OjhzNU[xNVE9N2F-
MOLM13	NVjtSHpXT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		NXnPb2lZPzJiaILz		NVnycFNlT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVU:OTUGzJINmdGy\|IHHmeIVzKDd{IHjyd{BjgSC{ZYPhfpVzcW5ib4KgUXRVKGG\|c3H5MEBIUTVyIE2gNE4xPjJizszNMi=>	NEW0fZo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEG1OlEyOSd-MkixOVYyOTF:L3G+
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MDA-MB-453	NVLCcXZvT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		MoH5O\|IhcHK\|		NVfmdpF7T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVUSDLV3CMVQ2OyClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG\|c3H5MEBIUTVyIE2gNE4{OjZizszNMi=>	M2f3TVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUW2NVEyLz5{OEG1OlEyOTxxYU6=
MCF7	MlHRS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		MV[3NkBpenN?		NX3UZnNkT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVUOINzDj[YxteyCjZoTldkA4OiCqcoOgZpkhemW\|YYr1dolvKG:{IF3UWEBie3OjeTygS2k2OCB;IECuOVU4KM7:TT6=	NF\6eoM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEG1OlEyOSd-MkixOVYyOTF:L3G+
M229	NYfpXI1xT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		MlexO\|IhcHK\|		MUjHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDNNlI6KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDy[ZNignW{aX6gc5IhVVSWIHHzd4F6NCCJSUWwJF0hOS5{MjFOwG0v	NVTYWoVRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkixOVYyOTFpPkK4NVU3OTFzPD;hQi=>
M238	NFLSSIlIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		NHXsblM4OiCqcoO=		Ml;BS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUVI{QCClZXzsd{Bi\nSncjC3NkBpenNiYomgdoV{[Xq3cnnuJI9zKE2WVDDhd5NigSxiR1m1NEA:KDFwOUeg{txONg>?	NHTaVWM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEG1OlEyOSd-MkixOVYyOTF:L3G+
M249	NVOwRVNCT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		NIe1ZmM4OiCqcoO=		MofQS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUVI1QSClZXzsd{Bi\nSncjC3NkBpenNiYomgdoV{[Xq3cnnuJI9zKE2WVDDhd5NigSxiR1m1NEA:KDFwOUmg{txONg>?	M37wUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUW2NVEyLz5{OEG1OlEyOTxxYU6=
M249R	Mmf5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		NVHRdVRpPzJiaILz		NUjoZXFrT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVTJ2OWKgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KHKnc3H6eZJqdiCxcjDNWHQh[XO\|YYmsJGdKPTBiPTCyMlk3KM7:TT6=	M17uO\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUW2NVEyLz5{OEG1OlEyOTxxYU6=
C4-2B	MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		M{DVVlczKGi{cx?=		MkXvS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gR\|QuOkJiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JJJme2G8dYLpckBweiCPVGSgZZN{[XluIFfJOVAhRSB2LkG1JO69VS5?	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDF3NkGxNUc,OjhzNU[xNVE9N2F-
DU145	NEDo[odIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		NYnFdFlkPzJiaILz		M{[xXGdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGRWOTR3IHPlcIx{KGGodHXyJFczKGi{czDifUBz\XOjeoXybY4hd3JiTWTUJIF{e2G7LDDHTVUxKD1iNT63PVIh\|ryPLh?=	NFfYOGY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEG1OlEyOSd-MkixOVYyOTF:L3G+
MDA-MB-468	NVTBc41LT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		MUK3NkBpenN?		M3LkfWdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG1FSS2PQj20Olgh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IILld4F7fXKrbjDvdkBOXFRiYYPzZZktKEeLNUCgQUA2Njl4IN88UU4>	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDF3NkGxNUc,OjhzNU[xNVE9N2F-
BPH1	MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		MWS3NkBpenN?		MmWzS5Jwf3SqIHnubIljcXSrb36gc4Yhdm:wdILhcpNnd3KvZXSgbJVu[W5iQmDINUBk\WyuczDh[pRmeiB5MjDodpMh[nlicnXzZZp2emmwIH;yJG1VXCCjc4PhfUwhT0l3MDC9JFcvPDR{IN88UU4>	Ml3OQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhzNU[xNVEoRjJ6MUW2NVEyRC:jPh?=
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MCF7	MU\D[YxtKGO7Y3zlJIFzemW\|dDDhd5NigQ>?	MXiwMlUhfG9iMTD1US=>	NXX3O21uOjRiaILz		MXfD[YxtKGO7Y3zlJIFzemW\|dDDpckBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W\|c3XkJIF{KGGlY4XteYxifGmxbjDheEBIOSCyaHHz[UBifCByLkWgeI8hOSC3TTDh[pRmeiB{NDDodpMh[nlicILvdIllcXWvIHnv[Ill\SC\|dHHpcolv\y2kYYPl[EBndG:5IHP5eI9u\XS{aXOgZY5idHm\|aYO=	MkGwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR2MUe1OlYoRjJ2NEG3OVY3RC:jPh?=
MDA-MB-231	MnrISpVv[3Srb36gZZN{[Xl?	MofvNE42KHSxIEWgeW0>	MmnsNlQhcHK\|		MlnwTY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDDSGs1N2O7Y3zpcmQyKGmwIHj1cYFvKE2GQT3NRk0zOzFiY3XscJMh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBz\XSrbn;icIF{fG:vYTDwbI9{eGixconsZZRqd25iYYSgV4VzPzhyIHH0JFAvPSC2bzC1JJVOKGGodHXyJFI1KGi{czDifUBY\XO2ZYLuJIJtd3S2aX7nJIFv[Wy7c3nz	MnHlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR2MUe1OlYoRjJ2NEG3OVY3RC:jPh?=
MDA-MB-231	NI\QTYVHfW6ldHnvckBie3OjeR?=	MWmwMlUhfG9iNTD1US=>	MoLONlQhcHK\|		M1;UcmlvcGmkaYTpc44hd2ZicnXjc41jcW6jboSgR2RMPC:leXPsbY5FOSCrbjDoeY1idiCPRFGtUWIuOjNzIHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4YhemW2aX7vZoxie3SxbXGgdIhwe3Cqb4L5cIF1cW:wIHH0JHNmejd6MDDheEAxNjVidH:gOUB2VSCjZoTldkAzPCCqcoOgZpkhX2W\|dHXyckBjdG:2dHnu[{BidmGueYPpdy=>	NFzVNJQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NESxO\|U3Pid-MkS0NVc2PjZ:L3G+
MCF7	NXv6XlRJTnWwY4Tpc44h[XO\|YYm=	MU[wMlUhfG9iNTD1US=>	NVnFZ4h1OjRiaILz		M3O2cWlvcGmkaYTpc44hd2ZicnXjc41jcW6jboSgR2RMPC:leXPsbY5FOSCrbjDoeY1idiCPQ1[3JINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZicnX0bY5w[myjc4TvcYEheGixc4Doc5J6dGG2aX;uJIF1KFOncke4NEBifCByLkWgeI8hPSC3TTDh[pRmeiB{NDDodpMh[nliV3XzeIVzdiCkbH;0eIlv\yCjbnHsfZNqew>?	NF\leXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NESxO\|U3Pid-MkS0NVc2PjZ:L3G+
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MV4-11	NV[2SXVXTnWwY4Tpc44h[XO\|YYm=		Mlq5NVIhfG9iMkSgbJJ{		Mln5TY5pcWKrdHnvckBw\iCFRFu0M\|YhcW5iaIXtZY4hVVZ2LUGxJINmdGy\|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiCUYjDwbI9{eGixconsZZRqd25iYYSgV4VzPzhyIHH0JGdKPTBiYX\0[ZIhOTJidH:gNlQhcHK\|IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>?	NGHNVGk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEG1OlEyOSd-MkixOVYyOTF:L3G+
MV4-11	MmTHSpVv[3Srb36gZZN{[Xl?		NFXZVIUyOiC2bzCyOEBpenN?		M1XBUGlvcGmkaYTpc44hd2ZiQ1TLOE83KGmwIHj1cYFvKE2YND2xNUBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iUnKgdIhwe3Cqb4L5cIF1cW:wIHH0JHNmejd6MDDheEBIUTVyIHHmeIVzKDF{IITvJFI1KGi{czDifUBY\XO2ZYLuJIJtd3RiYX7hcJl{cXN?	NXy5O3AxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkixOVYyOTFpPkK4NVU3OTFzPD;hQi=>
A673	NYOyTWRbeUiWUzDhd5NigQ>?				M13LfZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCDNkezJINmdGy\|	NULP[FR1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
Saos-2	NHjmcFhyUFSVIHHzd4F6				NGjmT41yUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiU3Hvd{0zKGOnbHzz	MnTsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
BT-37	MlO5dWhVWyCjc4PhfS=>				MWLxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhSlRvM{egZ4VtdHN?	MkjrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
RD	MUjxTHRUKGG\|c3H5				NXTKW5F2eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IGLEJINmdGy\|	M2XoT\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SK-N-SH	M1POVJFJXFNiYYPzZZk>				NIjr[o1yUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiU1utUk1UUCClZXzsdy=>	M4LtOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
NB1643	NXy3fIUyeUiWUzDhd5NigQ>?				MnHIdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKE6EMU[0N{Bk\Wyucx?=	NXjBbnFZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
OHS-50	NWfaZYMzeUiWUzDhd5NigQ>?				NXfTN4V3eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IF;IV{02OCClZXzsdy=>	NIfLZoI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
SK-N-MC	M4nTcpFJXFNiYYPzZZk>				Ml\WdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKFONLV6tUWMh[2WubIO=	M3niSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
NB-EBc1	NHr3SnZyUFSVIHHzd4F6				MnLvdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKE6ELVXCZ\|Eh[2WubIO=	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
LAN-5	MYLxTHRUKGG\|c3H5				MnH6dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKEyDTj21JINmdGy\|	MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
Rh18	NYLtOY9teUiWUzDhd5NigQ>?				MmHtdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKFKqMUigZ4VtdHN?	NYfndol4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	RB1 (pT821) / RB1 (pS780); PubMed: 30300583 Cancer cell Immunoblots showing dose-dependent impact of 72 hr palbociclib treatment on indicated protein levels in Kasumi-1 and SKNO-1 cells. pAMPKα(T172) / AMPKα; PubMed: 28453226 Mol Oncol Dose-dependent response of palbociclib on AMPK‐related molecules. HCC cells were treated with different concentrations of palbociclib for 24 h. The phosphorylation of the indicated proteins was determined by western blotting. pULK1(S317) / ULK1; PubMed: 28453226 Mol Oncol Dose-dependent response of palbociclib on AMPK‐related molecules. HCC cells were treated with different concentrations of palbociclib for 24 h. The phosphorylation of the indicated proteins was determined by western blotting. c-Jun / p-c-Jun / NFκB(p50); PubMed: 26540629 Oncotarget The expression of c-Jun and phosphorylated c-Jun was assessed using western blot after the cells were treated with palbociclib. p38 / p-P38 / JNK / p-JNK; PubMed: 26540629 Oncotarget MAPK pathway-related proteins, p38, ERK, JNK expression levels were detected.	30300583 28453226 26540629
Growth inhibition assay	Cell viability; PubMed: 28453226 Mol Oncol Dose- and time-dependent effects of palbociclib on cell viability in three HCC cell lines. Hep3B, Huh7, and PLC5 cells were treated with palbociclib at the indicated concentrations for 24 or 48 h and assayed by MTT. The solvent (DMSO) concentration in each sample is equal (0.7%). IC50; PubMed: 27099147 Blood Dose-response curve of ITD+ (red) or control (black) leukemic cells with CDK4/6 inhibitor palbociclib. Cells were incubated with increasing concentrations for 72 hours. Cell viability and proliferation were assessed by using the CTG assay. IC50 values were calculated by using GraphPad Prism software. Error bars indicate ± SEM.	28453226 27099147
Immunofluorescence	γH2AX(Ser139); PubMed: 29669860 EMBO J Representative maximum‐intensity projections of MCF7 cells treated with the 1 μM palbociclib and/or 7.5 nM bortezomib. Note that 7.5 nM bortezomib inhibits proteasome only partially. Fixed and permeabilized cells were stained with Alexa Fluor 488‐conjugated Ki67 antibody, Alexa Fluor 647‐conjugated phospho‐Histone H2A.X (γH2AX) (pSer139) antibody, and DAPI. All images were acquired with the same magnification, and scale bar is 20 μm. LC3B; PubMed: 28453226 Mol Oncol LC3B immunofluorescence in palbociclib‐treated Hep3B cells. Arrowheads indicate LC3‐positive autophagosomes. Nuclei were counterstained with DAPI (blue).	29669860 28453226
ELISA	PGE2; PubMed: 26540629 Oncotarget The supernatant of control and 7.5 μM palbociclib-treated cells was collected and stored at −80°C. PGE2 secretion was detected using ELISA.	26540629

体内研究

PD 0332991(150 mg/kg)作用于Colo-205结肠癌移植瘤，诱导肿瘤快速衰退，肿瘤生长相应延迟。PD 0332991(150 mg/kg)作用于MDA-MB-435乳腺癌，诱导全部肿瘤停滞和杀死细胞。PD 0332991(150 mg/kg)处理携带SF-295胶质母细胞瘤，和ZR-75-1乳腺癌和PC-3前列腺肿瘤模型(完全抑制肿瘤生长)的小鼠，显著诱导肿瘤衰退。PD 0332991 (150 mg/kg)处理 MDA-MB-435乳腺癌超过24小时，抑制Rb在Ser⁷⁸⁰位点磷酸化。PD 0332991(150 mg/kg)处理Colo-205 移植瘤，下调四种E2F调节的基因CDC2, CCNE2, TK1, 和 TOP2A表达。^[1]PD 0332991也快速抑制骨髓瘤生长。^[2]

激酶实验：^[4]	- 合并 CDK活性实验: 在96孔过滤板中进行动力学测评，测定CDK实验的IC50值。所有的CDK-cyclin激酶复合物在昆虫细胞中通过杆状病毒感染而表达，并进行纯化。实验底物是与GST(GST•RB-Cterm)融合的pRb组分(792–928位氨基酸)。总反应体积为0.1 mL，包含终浓度20 mM Tris-HCl,pH 7.4, 50 mM NaCl,1 mM 二硫苏糖醇,10 mM MgCl₂，含0.25 μCi[γ-³²P]ATP的25 μM ATP(作用于 CDK4-cyclin D1, CDK6-cyclin D2, 和 CDK6-cyclin D3), 20 ng 酶, 1 μg GST•RB-Cterm, 及适度稀释的抑制剂。每孔加入全部组分，除了[γ-³²P]ATP，置于混合器中2分钟。加入[γ-³²P]ATP开始反应,在25°C下温育15分钟。加入0.1 mL 20% 三氯乙酸终止反应, 实验板置于4°C至少1小时，使底物沉淀。每孔使用 0.2 mL 10%三氯乙酸洗涤五次，使用β计数器测定渗透的放射性。
细胞实验：^[3]	- 合并 Cell lines: 人类乳腺癌细胞MDA-MB-435 Concentrations: 2 μM Incubation Time: 6 天 Method: 细胞按一式两份每孔5,000 到10,000个细胞接种在24孔板中，接种后，加入不同浓度的PD 0332991。对照组不加入药物。温育末期，细胞胰蛋白酶化，并置于等渗溶液中，并立即使用Coulter Z2粒子计数器计数。 (Only for Reference)
动物实验：^[1]	- 合并 Animal Models: 人类结肠癌移植瘤Colo-205 Dosages: 150 mg/kg Administration: 每天口服处理 (Only for Reference)

参考文献

[4] Fry DW, et al. J Biol Chem, 2001, 276(20), 16617-16623.

- 合并

溶解度 (25°C)

体外	Water	10 mg/mL warmed (17.43 mM)
	DMSO	Insoluble
	Ethanol	Insoluble
体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： saline (with warming)	10mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download Palbociclib (PD0332991) Isethionate SDF

分子量	573.66
化学式	C₂₄H₂₉N₇O₂.C₂H₆O₄S
CAS号	827022-33-3
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	N/A

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

临床试验信息 (data from https://clinicaltrials.gov, updated on 2021-09-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04669587	Recruiting	Drug: ZB716\|Drug: Palbociclib	Estrogen Receptor-Positive\|HER2-Negative\|Locally Advanced Breast Cancer\|Metastatic Breast Cancer	EnhancedBio USA Inc.\|Zenopharm\|EnhancedBio Inc.	July 26 2021	Phase 1\|Phase 2
NCT04841148	Recruiting	Drug: HCQ\|Drug: Avelumab\|Drug: Palbociclib	Breast Cancer	Abramson Cancer Center of the University of Pennsylvania\|Johns Hopkins University\|Translational Breast Cancer Research Consortium\|Pfizer\|Breast Cancer Research Foundation	June 1 2021	Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

常见问题及建议解决方法

问题 1：
What is the best vehicle for palbociclib for in vitro and in vivo?
回答：
You can use water for vitro use and Saline for vivo use.

CDK Signaling Pathway Map

CDK Inhibitors with Unique Features

选择性强的CDK抑制剂

SNS-032 (BMS-387032) : CDK2-selective, IC50=48 nM.
活性最高的CDK抑制剂

LY2835219 : CDK4, IC50=2 nM; CDK6, IC50=10 nM.
用于临床的CDK抑制剂

Dinaciclib (SCH727965) : Phase III for Chronic Lymphocytic Leukemia (CLL).
最新的CDK抑制剂

NU6027

研究领域

产品类型

定制您的化合物库

Palbociclib (PD0332991) Isethionate

客户使用Selleck生产的Palbociclib (PD0332991) Isethionate发表文献219篇：

产品安全说明书

CDK抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download Palbociclib (PD0332991) Isethionate SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

临床试验信息 (data from https://clinicaltrials.gov, updated on 2021-09-06)

技术支持

常见问题及建议解决方法

CDK Signaling Pathway Map

CDK Inhibitors with Unique Features