Palbociclib (PD0332991) Isethionate

For research use only. Not for use in humans.

Pfizer辉瑞授权生产目录号：S1579

Palbociclib (PD0332991) Isethionate Chemical Structure

CAS No. 827022-33-3

Palbociclib (PD0332991) Isethionate是一种高度选择性的CDK4/6抑制剂，无细胞试验中IC50为11 nM/16 nM，对CDK1/2/5，EGFR，FGFR，PDGFR， InsR等没有抑制活性。Phase 3。

规格

价格

库存

购买数量

10mg	RMB 1217.51	现货
25mg	RMB 2189.47	现货
50mg	RMB 3026.06	现货
200mg	RMB 8763.3	现货
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客户使用Selleck生产的Palbociclib (PD0332991) Isethionate发表文献188篇：

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产品安全说明书

CDK抑制剂选择性比较

生物活性

产品描述

特性

PD 0332991治疗多种癌症，特异性抑制CDK4/6，是第一种有前途的抑制剂。

靶点

CDK4/CyclinD3 ^[1] (Cell-free assay)	CDK4/CyclinD1 ^[1] (Cell-free assay)	CDK6/CyclinD2 ^[1] (Cell-free assay)
9 nM	11 nM	15 nM

体外研究

PD 0332991对CDK4/6具有绝对选择性，对其他CDKs几乎没有抑制活性。PD 0332991作用于MDA-MB-435乳腺癌细胞，有效降低Rb在Ser780 和 Ser795位点磷酸化，IC50分别为66 nM和63 nM。PD 0332991通过抑制细胞进入S期，有效抑制细胞生长，抑制 DNA复制。PD 0332991抑制胸苷渗透进Rb阳性人类乳腺癌(如MDA-MB-435, MCF-7), 结肠癌 (H1299), 和肺癌(Colo-205) 及白血病(CRRF-CEM和K562)的DNA中，IC50值为0.04-0.17 μM。PD 0332991显著增强MDA-MB-453在G1期的百分比。^[1]PD 0332991作用于CD138⁺原发性骨髓瘤细胞，初级非转化的B细胞，MM1.S和CAG HMCLs细胞系，抑制Rb磷酸化，IC50分别为 <0.1 μM, 0.05 μM, 和 60-70 nM。PD 0332991作用于CD138⁺原发性骨髓瘤细胞和初级非转化的B细胞，诱导细胞停滞在G1期。PD 0332991诱导MM1.S细胞停滞在G1期，IC50为~0.05 μM。^[2]PD 0332991优先抑制Luminal雌激素受体阳性(包括HER2阳性)人类乳腺癌细胞系。PD 0332991作用于大部分敏感的细胞系，促进pRb和cyclin D1基因表达，且降低CDKN2A(p16)基因表达。PD 0332991作用于条件性抗ER抑制的细胞系，增强对Tamoxifen的敏感性。^[3]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
H157	NI\GWGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFvZb48xNTFyMDFOwG0>	Mn;DO\|IhcA>?		NF[4PGhKSzVyPUmg{txO	M1X1cFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4M{mwN\|QzLz5{NkO5NFM1OjxxYU6=
H2170	NIDy[\|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{j1R\|AuOTByIN88US=>	M1[yWlczKGh?		MkHjTWM2OD13IN88US=>	MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjN7MEO0Nkc,OjZ\|OUCzOFI9N2F-
H520	M3HGWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4nnclAuOTByIN88US=>	NVLJNFhxPzJiaB?=		MnnFTWM2OD1yLkezJO69VQ>?	NGC1cpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkO5NFM1Oid-Mk[zPVA{PDJ:L3G+
H596	M4HVXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3G5V\|AuOTByIN88US=>	NWLUTHdoPzJiaB?=		NYjJUXZGUUN3ME2xNkDPxE1?	M4ruXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4M{mwN\|QzLz5{NkO5NFM1OjxxYU6=
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MV4-11	NVLUbJFySXCxcITvd4l{KEG\|c3H5	NX7XeGk5OC53IN88US=>	NIXz[VUzPCCq		MkXq[Y5p[W6lZYOgZZBweHSxc3nzJIlv\HWlZXSgZpkhe2:{YX\lcoljKGGwZDDBR\|IzOA>?	MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR6N{mxO{c,OjV2OEe5NVc9N2F-
MOLM13	MnPxRZBweHSxc3nzJGF{e2G7	M2GwZ\|AvPSEQvF2=	MUCyOEBp		M4Lmd4VvcGGwY3XzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KHOxcnHm[Y5q[iCjbnSgRWMzOjB?	NHPY[XY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUS4O\|kyPyd-MkW0PFc6OTd:L3G+
MOLM13-ITD alone	MlX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NV7vRWVjUUN3ME2wMlA5QSEEsTCwMlAxQSEQvF2=	MkDrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2OEe5NVcoRjJ3NEi3PVE4RC:jPh?=
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MV4-11-ITD/F691L	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{TySGlEPTB;MD6xNVIhyrFiMD6wNVUh\|ryP	NF7JPYI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUS4O\|kyPyd-MkW0PFc6OTd:L3G+
MV4-11-ITD/N841K	MmrDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYWzOXFsUUN3ME2wMlEyOyEEsTCwMlAxOiEQvF2=	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR6N{mxO{c,OjV2OEe5NVc9N2F-
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MOLT-16	MWPHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				NHy2N2tKSzVyIE2gNE4zPTh2OTFOwG0>	NInweYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
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KY821	NFzrcG9Iem:5dHigTY5pcWKrdHnvckBie3OjeR?=				MlrGTWM2OCB;IECuN\|E1OSEQvF2=	M4XafFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
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HL-60	NIPPN49Iem:5dHigTY5pcWKrdHnvckBie3OjeR?=				M1vmNWlEPTBiPTCwMlM1ODZ4IN88US=>	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
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KARPAS-45	MmfuS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				MUTJR\|UxKD1iMD6zO\|YyPiEQvF2=	MkT4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
SK-N-AS	Mmr4S5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				MnHETWM2OCB;IECuN\|g4QDNizszN	Mlf6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
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TYK-nu	M3HjW2dzd3e2aDDJcohq[mm2aX;uJIF{e2G7				MUfJR\|UxKD1iMD65PVgzPSEQvF2=	NHn2Smo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
KYSE-150	NWHROnQ1T3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				MlGxTWM2OCB;IEGuNFAxPzZizszN	NF\i[ng9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
SN12C	MkK4S5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				M4S0XGlEPTBiPTCxMlAxQDd3IN88US=>	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
MOLT-13	Ml;qS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				MoO0TWM2OCB;IEGuNFE1OjFizszN	MmfSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
TE-11	Ml3ES5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				MkOyTWM2OCB;IEGuNFQ5OTJizszN	M16yblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
DB	NWnzeIxMT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				MofBTWM2OCB;IEGuNFczPzNizszN	M1vJNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
CAL-39	Moi2S5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				M4n4fGlEPTBiPTCxMlA4PTJ{IN88US=>	M{TCWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
A3-KAW	NVrYbHk6T3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				M2rT[mlEPTBiPTCxMlA5PDB6IN88US=>	NFHDO2I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
CHP-134	NGHOcHVIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				NWXkVnlYUUN3MDC9JFEvOTF6MEeg{txO	MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
TGW	MYjHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				NFzXOo9KSzVyIE2gNU4yOjN7NTFOwG0>	NWTJTGVlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
QIMR-WIL	MULHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				MU\JR\|UxKD1iMT6xN\|E{PCEQvF2=	Ml;FQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
NCI-SNU-1	M2LVWGdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				NXO3c4ltUUN3MDC9JFEvOTZ\|NUSg{txO	M1[zWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
CGTH-W-1	NXLHelRwT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				NW\sTJhxUUN3MDC9JFEvOTdzOE[g{txO	Ml;VQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
MHH-ES-1	MonXS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				Mly2TWM2OCB;IEGuNVc6QDZizszN	NYrz[GY2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
LB2241-RCC	M{C3N2dzd3e2aDDJcohq[mm2aX;uJIF{e2G7				MVfJR\|UxKD1iMT6xPFYzKM7:TR?=	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
ML-2	M1XufWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				NUe3UJQ1UUN3MDC9JFEvOjB5M{Sg{txO	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
COR-L23	NHzhXmxIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				Ml7VTWM2OCB;IEGuNlI6OzNizszN	NGXXZZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
BFTC-905	MUHHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				NG\kO3dKSzVyIE2gNU4zPDJ4NzFOwG0>	Mny4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
Hs-578-T	M3jLPWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				M1XRVmlEPTBiPTCxMlI2QDF5IN88US=>	NIHES4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
KG-1	NUDXN4JtT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				M3zsTGlEPTBiPTCxMlI3Pjh4IN88US=>	MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
HEL	MmPiS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				NHTMOoNKSzVyIE2gNU4zQTN\|ODFOwG0>	NGjlRmM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
A549	MoDaS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				NVrZeFhYUUN3MDC9JFEvOjl\|OUmg{txO	NVLXTnd6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
COLO-741	NHzyZ5BIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				Mn7sTWM2OCB;IEGuN\|IxQDlizszN	NWr5SW44RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
PC-3	MmXaS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				NWfSV2IxUUN3MDC9JFEvOzV{MkGg{txO	M3vRTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
HOS	MWrHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				M3y1dGlEPTBiPTCxMlM2Ojl4IN88US=>	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
HT-1080	MYLHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				MkHZTWM2OCB;IEGuN\|c2OTlizszN	M2[ycFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
TE-8	NFLwfXdIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				NEjHO25KSzVyIE2gNU41OTd5NDFOwG0>	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
BHY	NF\IfXFIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				MnTHTWM2OCB;IEGuOFY6OjNizszN	NH7QWGs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
BB65-RCC	NI\lPIRIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				MUnJR\|UxKD1iMT61NFUzQCEQvF2=	NIKxZVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
HN	NVq4[YVOT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				MnfRTWM2OCB;IEGuOVQxPzFizszN	MlPkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
NCI-H441	NXPZ[mxiT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				MXjJR\|UxKD1iMT61OFkxPyEQvF2=	NFXvVHQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
RPMI-8866	MnywS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				NI\GTYFKSzVyIE2gNU42QDVyNzFOwG0>	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
CAL-62	MmDXS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				NH62dGNKSzVyIE2gNU43ODh4MjFOwG0>	NXLHZll{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
MG-63	Ml;BS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				MmrjTWM2OCB;IEGuOlE5OTNizszN	M4nKb\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
SK-LU-1	MVfHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				MVPJR\|UxKD1iMT62NlE2OiEQvF2=	NGDQ[2g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
BCPAP	M3;aRWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				MXHJR\|UxKD1iMT62OlQ2PyEQvF2=	M1XvWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
22RV1	M1G4Vmdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				M{\uOGlEPTBiPTCxMlY4QDR\|IN88US=>	NWL0dXl7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
T47D	NUfvSIRtT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				NF7BdYJKSzVyIE2gNU43QDB4MTFOwG0>	M3rwXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
MSTO-211H	NV\6[plIT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				MmXPTWM2OCB;IEGuOlk3ODNizszN	MoHJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
DEL	MorkS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				NIDaVIZKSzVyIE2gNU44ODJ5MzFOwG0>	NFPVW2E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
H4	MknHS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				NHXib2tKSzVyIE2gNU44OzJzMjFOwG0>	NEXmVJM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
CAL-51	NGrpVIhIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				NVL6[4E1UUN3MDC9JFEvPzR6NUWg{txO	Ml\NQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
ABC-1	NXLzTHNjT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				NIDOOZBKSzVyIE2gNU44QDV6MjFOwG0>	NX7YOpE1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
MZ2-MEL	NH\jNGZIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				NFnEPI1KSzVyIE2gNU44QTV2MjFOwG0>	MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
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EPLC-272H	M3TRdmdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				M1WzVGlEPTBiPTCxPU4xPDN2IN88US=>	NX3HVnNiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
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KYSE-410	NEjyZoJIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				NXGyU4JDUUN3MDC9JFE6NjlzM{mg{txO	M2rGNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
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KYSE-70	M4mwcGdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				M4HTXmlEPTBiPTCyNE45ODV7IN88US=>	NVL1SplwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
CAL-72	M3HkVWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				M3To[2lEPTBiPTCyNE46OTVizszN	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
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PFSK-1	MXjHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				NW\1TGtmUUN3MDC9JFU{Oi57NEGg{txO	MkDxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
MOLM13	M3nFZ2Z2dmO2aX;uJIF{e2G7		NEf1bJYzPCCqcoO=		NXKyTWE3UW6qaXLpeIlwdiCxZjDDSGs1KGmwIHj1cYFvKE2RTF2xN{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIGLiJJBpd3OyaH;yfYxifGmxbjDheEBU\XJ5OECgZYZ1\XJiMkSgbJJ{NCCLQ{WwJF0hOC5yMUGg{txONg>?	NUjTWoE3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2OFEyODNpPkK0OlQyOTB\|PD;hQi=>
COLO205	MknvRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		M3nuflczKGi{cx?=		NEPCWnFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JHJjNXCxc3n0bZZmKGi3bXHuJGNQVE9{MEWgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kd3Kyb4LheIlwdiCxZjDbN2hefGi7bXnkbY5mKGmwdH:gSG5CKGGodHXyJFczKGi{czDifUBj\XSjLYDsZZRmKGOxdX70bY5oKGGwYXz5d4l{NCCLQ{WwJF0hOC5yM{[g{txONg>?	NUPp[FFzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2OFEyODNpPkK0OlQyOTB\|PD;hQi=>
MOLM13	MXzBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NYSxWHJ1PzJiaILz		MYjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2RTF2xN{Bk\WyuczDoZZJjd3KrbnegSmxVOyCLVFSgcZV1[W62IHHzd4V{e2WmIHHzJIlv[2:{cH;yZZRqd25ib3[gX\|NJZXSqeX3p[Ilv\SCrboTvJGRPSSCjZoTldkA4OiCqcoOgZpkh[mW2YT3wcIF1\SClb4XueIlv\yCjbnHsfZNqeyxiSVO1NEA:KDBwMEm2JO69VS5?	NXrpc3BbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2OFEyODNpPkK0OlQyOTB\|PD;hQi=>
MOLM13	MWrBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NVTTe49mPzJiaILz		MYnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IIPvdoFn\W6rYj3y[ZNqe3SjboSgbJVu[W5iTV;MUVE{KGOnbHzzJIF{e2W\|c3XkJIF{KGmwY3;ydI9z[XSrb36gc4YhYzOKXYTofY1q\GmwZTDpcpRwKESQQTDh[pRmeiB5MjDodpMh[nliYnX0ZU1xdGG2ZTDjc5VvfGmwZzDhcoFtgXOrczygTWM2OCB;IECuNFk3KM7:TT6=	NV\IRpdDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2OFEyODNpPkK0OlQyOTB\|PD;hQi=>
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insect cell	M17BW2Z2dmO2aX;uJIF{e2G7		MoHaNkBucW6\|		NVrEdGpvUW6qaXLpeIlwdiCxZjDDSGs3N2O7Y3zpckBFOiBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDiZYN2dG:4aYL1d{Bqdm[nY4Tl[EBqdnOnY4SgZ4VtdHNidYPpcochT1OWLX\1d4VlKHCUYjCoO\|kzKHSxIEmyPEkh[XNic4Xid5Rz[XSnIIDy[Ylv[3WkYYTl[EBnd3JiMjDtbY5{KG[xbHzve4VlKGK7IGvnZY1u[S1\|MmDdMWFVWCCjZHTpeIlwdiCvZXHzeZJm\CCjZoTldkAyPSCvaX7zJIJ6KGKndHGgdIxifGViY3;1cpRqdmdiYX7hcJl{cXNuIFnDOVAhRSByLkCwPUDPxE1w	M1XTUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MUG1OVcyLz5{NkGxOVU4OTxxYU6=
insect cell	NX3yV21ITnWwY4Tpc44h[XO\|YYm=		M{C4TlIhdWmwcx?=		Mn[wTY5pcWKrdHnvckBw\iCFRFu2M4N6[2yrbjDENkApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCkYXP1cI93cXK3czDpcoZm[3SnZDDpcpNm[3RiY3XscJMhfXOrbnegS3NVNW[3c3XkJJBT[iBqN{myJJRwKDl{ODmgZZMhe3Wkc4TyZZRmKHC{ZXnuZ5Vj[XSnZDDmc5IhOiCvaX7zJIZwdGyxd3XkJIJ6KFupYX3tZU0{OlCfLVHUVEBi\GSrdHnvckBu\WG\|dYLl[EBi\nSncjCxOUBucW6\|IHL5JIJmfGFicHzheIUh[2:3boTpcoch[W6jbInzbZMtKEmFNUCgQUAxNjByOTFOwG0v	MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjFzNUW3NUc,OjZzMUW1O\|E9N2F-
insect cell	MonYSpVv[3Srb36gZZN{[Xl?		MXmyJI1qdnN?		MlS5TY5pcWKrdHnvckBw\iCFRFu0M4N6[2yrbjDENUApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCkYXP1cI93cXK3czDpcoZm[3SnZDDpcpNm[3RiY3XscJMhfXOrbnegS3NVNW[3c3XkJJBT[iBqN{myJJRwKDl{ODmgZZMhe3Wkc4TyZZRmKHC{ZXnuZ5Vj[XSnZDDmc5IhOiCvaX7zJIZwdGyxd3XkJIJ6KFupYX3tZU0{OlCfLVHUVEBi\GSrdHnvckBu\WG\|dYLl[EBi\nSncjCxOUBucW6\|IHL5JIJmfGFicHzheIUh[2:3boTpcoch[W6jbInzbZMtKEmFNUCgQUAxNjBzMTFOwG0v	M2fP[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MUG1OVcyLz5{NkGxOVU4OTxxYU6=
insect cell	NFvw[XFHfW6ldHnvckBie3OjeR?=		M1K0VlIhdWmwcx?=		NFjKdHJKdmirYnn0bY9vKG:oIFPET\|Qw[3mlbHnuJGQyKCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIHLhZ5Vtd3[rcoXzJIlv\mWldHXkJIlve2WldDDj[YxteyC3c3nu[{BIW1RvZoXz[YQheFKkIDi3PVIhfG9iOUK4LUBieyC\|dXLzeJJifGVicILlbY5kfWKjdHXkJIZweiB{IH3pcpMh\m:ubH;3[YQh[nliW3fhcY1iNTN{UG2tRXRRKGGmZHn0bY9vKG2nYYP1doVlKGGodHXyJFE2KG2rboOgZpkh[mW2YTDwcIF1\SClb4XueIlv\yCjbnHsfZNqeyxiSVO1NEA:KDBwMEGxJO69VS5?	M1rTVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MUG1OVcyLz5{NkGxOVU4OTxxYU6=
MDA-MB-435	NEDGd4pCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NGnV[VQzPCCqcoO=		Ml;6RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDSZk1xd3OrdHn2[UBpfW2jbjDNSGEuVUJvNEO1JINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiW{G0R30ufGi7bXnkbY5mKGmwY3;ydI9z[XSrb36gbY51dyCGTlGgdJJmcW6ldXLheIVlKG[xcjCyOEBpenNiZn;scI94\WRiYomgX\|E1S11vdHj5cYllcW6nIHHk[Il1cW:wIH3lZZN2emWmIHHmeIVzKDd{IHjyd{BjgSCkZYThJJBt[XSnIHPveY51cW6pIHHuZYx6e2m\|LDDJR\|UxKD1iMD6xOkDPxE1w	MnL3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzMUW1O\|EoRjJ4MUG1OVcyRC:jPh?=
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insect cell	MVzGeY5kfGmxbjDhd5NigQ>?		MnjINkBucW6\|		MoHUTY5pcWKrdHnvckBw\iCFRFu0M4N6[2yrbjDENUApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCkYXP1cI93cXK3czDpcoZm[3SnZDDpcpNm[3RiY3XscJMhfXOrbnegS3NVNXSjZ3fl[EBxWkJiKEe5NkB1dyB7MkigdoV{cWS3ZYOpJIF{KHO3YoP0doF1\SCycnXpcoN2[mG2ZXSg[o9zKDJibXnud{Bnd2yub4fl[EBjgSCdZ3HtcYE{OlCfQWTQJIFl\Gm2aX;uJI1m[XO3cnXkJIFnfGW{IEG1JI1qdnNiYomgZoV1[SClb4XueIlv\yCvZYToc4QtKEmFNUCgQUAxNjBzMTFOwG0v	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzF5MUCzOkc,OjdzN{GwN\|Y9N2F-
insect cell	NHvNfmtHfW6ldHnvckBie3OjeR?=		MVmyJI1qdnN?		NYrST3RiUW6qaXLpeIlwdiCxZjDDSGs1N2O7Y3zpckBFOSBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDiZYN2dG:4aYL1d{Bqdm[nY4Tl[EBqdnOnY4SgZ4VtdHNidYPpcochT1OWLYTh[4dm\CCyUlKgLFc6OiC2bzC5NlghemW\|aXT1[ZMqKGG\|IIP1ZpN1emG2ZTDwdoVqdmO3YnH0[YQh\m:{IEKgcYlveyCob3zsc5dm\CCkeTDb[4FudWF\|MmDdRXRRKGGmZHn0bY9vKG2nYYP1doVlKGGodHXyJFE2KG2rboOgZpkh[mW2YTDjc5VvfGmwZzDt[ZRpd2RuIFnDOVAhRSByLkCxNUDPxE1w	M3m2Z\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUexNFM3Lz5{N{G3NVA{PjxxYU6=
insect cell	MVjGeY5kfGmxbjDhd5NigQ>?		M4X4Z\|IhdWmwcx?=		MmDBTY5pcWKrdHnvckBw\iCFRFu2M4N6[2yrbjDENkApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCkYXP1cI93cXK3czDpcoZm[3SnZDDpcpNm[3RiY3XscJMhfXOrbnegS3NVNXSjZ3fl[EBxWkJiKEe5NkB1dyB7MkigdoV{cWS3ZYOpJIF{KHO3YoP0doF1\SCycnXpcoN2[mG2ZXSg[o9zKDJibXnud{Bnd2yub4fl[EBjgSCdZ3HtcYE{OlCfQWTQJIFl\Gm2aX;uJI1m[XO3cnXkJIFnfGW{IEG1JI1qdnNiYomgZoV1[SClb4XueIlv\yCvZYToc4QtKEmFNUCgQUAxNjBzNTFOwG0v	Ml;6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzN{GwN\|YoRjJ5MUexNFM3RC:jPh?=
insect cell	NVHNe\|VrTnWwY4Tpc44h[XO\|YYm=		NVfYNllZOiCvaX7z		MlX3TY5pcWKrdHnvckBw\iCFRFu2M4N6[2yrbjDENkApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCkYXP1cI93cXK3czDpcoZm[3SnZDDpcpNm[3RiY3XscJMhfXOrbnegS3NVNXSjZ3fl[EBxWkJiKEe5NkB1dyB7MkigdoV{cWS3ZYOpJIF{KHO3YoP0doF1\SCycnXpcoN2[mG2ZXSg[o9zKDJibXnud{Bnd2yub4fl[EBjgSCdZ3HtcYE{OlCfQWTQJIFl\Gm2aX;uJI1m[XO3cnXkJIFnfGW{IEG1JI1qdnNiYomgZoV1[SClb4XueIlv\yCvZYToc4QtKEmFNUCgQUAxNjBzNTFOwG0v	NXjxRVlZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexO\|ExOzZpPkK3NVcyODN4PD;hQi=>
MDA-MB-453	NVjad\|hUS3m2b4TvfIlkcXS7IHHzd4F6		M4nqVFQ5KGi{cx?=		M1rTXWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj20OVMh[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFQ5KGi{czDifUBES0t6IHHzd4F6NCCLQ{WwJF0hOC5zM{eg{txONg>?	NYmxWVRMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke0OFg6OTNpPkK3OFQ5QTF\|PD;hQi=>
MCF7	M4H5SGN6fG:2b4jpZ4l1gSCjc4PhfS=>		M2fkT\|Q5KGi{cx?=		NFnHb5BEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliQ1PLPEBie3OjeTygTWM2OCB;IECuNlQh\|ryPLh?=	MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzR2OEmxN{c,Ojd2NEi5NVM9N2F-
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MDA-MB-468	MmPCS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		NESwO2Q4OiCqcoO=		NWDMdnZwT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVUSDLV3CMVQ3QCClZXzsd{Bi\nSncjC3NkBpenNiYomgdoV{[Xq3cnnuJI9zKE2WVDDhd5NigSxiR1m1NEA:KDVwOU[g{txONg>?	M1TYPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUW2NVEyLz5{OEG1OlEyOTxxYU6=
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MDA-MB-231	NUTLcYZVS2WubDDjfYNt\SCjcoLld5Qh[XO\|YYm=	M1y0OFAvPSC2bzCxJJVO	M3jCR\|I1KGi{cx?=		M1TuemNmdGxiY4njcIUh[XK{ZYP0JIlvKGi3bXHuJG1FSS2PQj2yN\|Eh[2WubIOgZZN{\XO\|ZXSgZZMh[WOldX31cIF1cW:wIHH0JGcyKHCqYYPlJIF1KDBwNTD0c{AyKHWPIHHmeIVzKDJ2IHjyd{BjgSCycn;wbYRqfW1iaX;kbYRmKHO2YXnubY5oNWKjc3XkJIZtd3diY4n0c41mfHKrYzDhcoFtgXOrcx?=	MoDvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR2MUe1OlYoRjJ2NEG3OVY3RC:jPh?=
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MDA-MB-231	NXXLfFlsTnWwY4Tpc44h[XO\|YYm=	MY[wMlUhfG9iNTD1US=>	NWrVOm4xOjRiaILz		MnfyTY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDDSGs1N2O7Y3zpcmQyKGmwIHj1cYFvKE2GQT3NRk0zOzFiY3XscJMh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBz\XSrbn;icIF{fG:vYTDwbI9{eGixconsZZRqd25iYYSgV4VzPzhyIHH0JFAvPSC2bzC1JJVOKGGodHXyJFI1KGi{czDifUBY\XO2ZYLuJIJtd3S2aX7nJIFv[Wy7c3nz	M4XSR\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEG3OVY3Lz5{NESxO\|U3PjxxYU6=
MDA-MB-231	MXPGeY5kfGmxbjDhd5NigQ>?	NFHBc28xNjVidH:gOUB2VQ>?	NILVN\|kzPCCqcoO=		Mlv6TY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDDSGs1N2O7Y3zpcmQyKGmwIHj1cYFvKE2GQT3NRk0zOzFiY3XscJMh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBz\XSrbn;icIF{fG:vYTDwbI9{eGixconsZZRqd25iYYSgV4VzPzhyIHH0JFAvPSC2bzC1JJVOKGGodHXyJFI1KGi{czDifUBY\XO2ZYLuJIJtd3S2aX7nJIFv[Wy7c3nz	M2DPRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEG3OVY3Lz5{NESxO\|U3PjxxYU6=
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BT-37	MkHzdWhVWyCjc4PhfS=>				NXjlUol5eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IFLUMVM4KGOnbHzz	M4X4[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
RD	MWnxTHRUKGG\|c3H5				MWLxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhWkRiY3XscJM>	M3r4N\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SK-N-SH	M1TtfpFJXFNiYYPzZZk>				Ml;LdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKFONLV6tV2gh[2WubIO=	NIT0SFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
NB1643	NEnFWnNyUFSVIHHzd4F6				M{njO5FJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCQQkG2OFMh[2WubIO=	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
OHS-50	MVzxTHRUKGG\|c3H5				NYXvZ28{eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IF;IV{02OCClZXzsdy=>	M3XqTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SK-N-MC	MoLCdWhVWyCjc4PhfS=>				NV3JSmpPeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IGPLMW4uVUNiY3XscJM>	NHrQblc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
NB-EBc1	MXTxTHRUKGG\|c3H5				NVXGOVdjeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IF7CMWVD[zFiY3XscJM>	NUHlO3dsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
LAN-5	NUfpXZZkeUiWUzDhd5NigQ>?				M4XwT5FJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCOQV6tOUBk\Wyucx?=	MmHVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
Rh18	MkDMdWhVWyCjc4PhfS=>				NFPsPHdyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiUnixPEBk\Wyucx?=	MmnQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	RB1 (pT821) / RB1 (pS780); PubMed: 30300583 Cancer cell Immunoblots showing dose-dependent impact of 72 hr palbociclib treatment on indicated protein levels in Kasumi-1 and SKNO-1 cells. pAMPKα(T172) / AMPKα; PubMed: 28453226 Mol Oncol Dose-dependent response of palbociclib on AMPK‐related molecules. HCC cells were treated with different concentrations of palbociclib for 24 h. The phosphorylation of the indicated proteins was determined by western blotting. pULK1(S317) / ULK1; PubMed: 28453226 Mol Oncol Dose-dependent response of palbociclib on AMPK‐related molecules. HCC cells were treated with different concentrations of palbociclib for 24 h. The phosphorylation of the indicated proteins was determined by western blotting. c-Jun / p-c-Jun / NFκB(p50); PubMed: 26540629 Oncotarget The expression of c-Jun and phosphorylated c-Jun was assessed using western blot after the cells were treated with palbociclib. p38 / p-P38 / JNK / p-JNK; PubMed: 26540629 Oncotarget MAPK pathway-related proteins, p38, ERK, JNK expression levels were detected.	30300583 28453226 26540629
Growth inhibition assay	Cell viability; PubMed: 28453226 Mol Oncol Dose- and time-dependent effects of palbociclib on cell viability in three HCC cell lines. Hep3B, Huh7, and PLC5 cells were treated with palbociclib at the indicated concentrations for 24 or 48 h and assayed by MTT. The solvent (DMSO) concentration in each sample is equal (0.7%). IC50; PubMed: 27099147 Blood Dose-response curve of ITD+ (red) or control (black) leukemic cells with CDK4/6 inhibitor palbociclib. Cells were incubated with increasing concentrations for 72 hours. Cell viability and proliferation were assessed by using the CTG assay. IC50 values were calculated by using GraphPad Prism software. Error bars indicate ± SEM.	28453226 27099147
Immunofluorescence	γH2AX(Ser139); PubMed: 29669860 EMBO J Representative maximum‐intensity projections of MCF7 cells treated with the 1 μM palbociclib and/or 7.5 nM bortezomib. Note that 7.5 nM bortezomib inhibits proteasome only partially. Fixed and permeabilized cells were stained with Alexa Fluor 488‐conjugated Ki67 antibody, Alexa Fluor 647‐conjugated phospho‐Histone H2A.X (γH2AX) (pSer139) antibody, and DAPI. All images were acquired with the same magnification, and scale bar is 20 μm. LC3B; PubMed: 28453226 Mol Oncol LC3B immunofluorescence in palbociclib‐treated Hep3B cells. Arrowheads indicate LC3‐positive autophagosomes. Nuclei were counterstained with DAPI (blue).	29669860 28453226
ELISA	PGE2; PubMed: 26540629 Oncotarget The supernatant of control and 7.5 μM palbociclib-treated cells was collected and stored at −80°C. PGE2 secretion was detected using ELISA.	26540629

体内研究

PD 0332991(150 mg/kg)作用于Colo-205结肠癌移植瘤，诱导肿瘤快速衰退，肿瘤生长相应延迟。PD 0332991(150 mg/kg)作用于MDA-MB-435乳腺癌，诱导全部肿瘤停滞和杀死细胞。PD 0332991(150 mg/kg)处理携带SF-295胶质母细胞瘤，和ZR-75-1乳腺癌和PC-3前列腺肿瘤模型(完全抑制肿瘤生长)的小鼠，显著诱导肿瘤衰退。PD 0332991 (150 mg/kg)处理 MDA-MB-435乳腺癌超过24小时，抑制Rb在Ser⁷⁸⁰位点磷酸化。PD 0332991(150 mg/kg)处理Colo-205 移植瘤，下调四种E2F调节的基因CDC2, CCNE2, TK1, 和 TOP2A表达。^[1]PD 0332991也快速抑制骨髓瘤生长。^[2]

激酶实验：^[4]	- 合并 CDK活性实验: 在96孔过滤板中进行动力学测评，测定CDK实验的IC50值。所有的CDK-cyclin激酶复合物在昆虫细胞中通过杆状病毒感染而表达，并进行纯化。实验底物是与GST(GST•RB-Cterm)融合的pRb组分(792–928位氨基酸)。总反应体积为0.1 mL，包含终浓度20 mM Tris-HCl,pH 7.4, 50 mM NaCl,1 mM 二硫苏糖醇,10 mM MgCl₂，含0.25 μCi[γ-³²P]ATP的25 μM ATP(作用于 CDK4-cyclin D1, CDK6-cyclin D2, 和 CDK6-cyclin D3), 20 ng 酶, 1 μg GST•RB-Cterm, 及适度稀释的抑制剂。每孔加入全部组分，除了[γ-³²P]ATP，置于混合器中2分钟。加入[γ-³²P]ATP开始反应,在25°C下温育15分钟。加入0.1 mL 20% 三氯乙酸终止反应, 实验板置于4°C至少1小时，使底物沉淀。每孔使用 0.2 mL 10%三氯乙酸洗涤五次，使用β计数器测定渗透的放射性。
细胞实验：^[3]	- 合并 Cell lines: 人类乳腺癌细胞MDA-MB-435 Concentrations: 2 μM Incubation Time: 6 天 Method: 细胞按一式两份每孔5,000 到10,000个细胞接种在24孔板中，接种后，加入不同浓度的PD 0332991。对照组不加入药物。温育末期，细胞胰蛋白酶化，并置于等渗溶液中，并立即使用Coulter Z2粒子计数器计数。 (Only for Reference)
动物实验：^[1]	- 合并 Animal Models: 人类结肠癌移植瘤Colo-205 Dosages: 150 mg/kg Administration: 每天口服处理 (Only for Reference)

参考文献

[4] Fry DW, et al. J Biol Chem, 2001, 276(20), 16617-16623.

- 合并

溶解度 (25°C)

体外	Water	10 mg/mL warmed (17.43 mM)
	DMSO	Insoluble
	Ethanol	Insoluble
体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： saline (with warming)	10mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download Palbociclib (PD0332991) Isethionate SDF

分子量	573.66
化学式	C₂₄H₂₉N₇O₂.C₂H₆O₄S
CAS号	827022-33-3
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	N/A

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

临床试验信息 (data from https://clinicaltrials.gov, updated on 2020-01-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04669587	Not yet recruiting	Drug: ZB716\|Drug: Palbociclib	Estrogen Receptor-Positive\|HER2-Negative\|Advanced\|Metastatic Breast Cancer	EnhancedBio USA Inc.\|Zenopharm LLC\|EnhancedBio Inc.	February 1 2021	Phase 1\|Phase 2
NCT04671615	Active not recruiting	Drug: palbociclib	Metastatic Breast Cancer	Pfizer	December 6 2020	--
NCT04567420	Not yet recruiting	Drug: Palbociclib\|Drug: Fulvestrant\|Drug: Adjuvant Therapy	Breast Cancer	Criterium Inc.	December 15 2020	Phase 2
NCT04654208	Not yet recruiting	Drug: palbociclib	Malignant Neoplasm of Breast	Pfizer	November 30 2020	--
NCT04483505	Recruiting	Drug: Combination Rogaratinib + palbociclib + fulvestrant	Breast Cancer Metastatic\|Hormone Receptor Positive Malignant Neoplasm of Breast	Fundacion CRIS de Investigación para Vencer el Cáncer\|Bayer\|Pfizer\|Apices Soluciones S.L.	November 25 2020	Phase 1

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

常见问题及建议解决方法

问题 1：
What is the best vehicle for palbociclib for in vitro and in vivo?
回答：
You can use water for vitro use and Saline for vivo use.

CDK Signaling Pathway Map

CDK Inhibitors with Unique Features

选择性强的CDK抑制剂

BS-181 HCl : CDK7-selective, IC50=21 nM.
选择性强的CDK抑制剂

SNS-032 (BMS-387032) : CDK2-selective, IC50=48 nM.
活性最高的CDK抑制剂

LY2835219 : CDK4, IC50=2 nM; CDK6, IC50=10 nM.
用于临床的CDK抑制剂

Dinaciclib (SCH727965) : Phase III for Chronic Lymphocytic Leukemia (CLL).
最新的CDK抑制剂

NU6027 : Potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with K_i of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurine-based inhibitors.

研究领域

产品类型

定制您的化合物库

Palbociclib (PD0332991) Isethionate

客户使用Selleck生产的Palbociclib (PD0332991) Isethionate发表文献188篇：

产品安全说明书

CDK抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download Palbociclib (PD0332991) Isethionate SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

临床试验信息 (data from https://clinicaltrials.gov, updated on 2020-01-06)

技术支持

常见问题及建议解决方法

CDK Signaling Pathway Map

CDK Inhibitors with Unique Features

相关CDK产品