Palbociclib (PD0332991) Isethionate

For research use only. Not for use in humans.

Pfizer辉瑞授权生产目录号：S1579

Palbociclib (PD0332991) Isethionate Chemical Structure

CAS No. 827022-33-3

Palbociclib (PD0332991) Isethionate是一种高度选择性的CDK4/6抑制剂，无细胞试验中IC50为11 nM/16 nM，对CDK1/2/5，EGFR，FGFR，PDGFR， InsR等没有抑制活性。Phase 3。

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10mg	RMB 1217.51	现货
25mg	RMB 2189.47	现货
50mg	RMB 3026.06	现货
200mg	RMB 8763.3	现货
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客户使用Selleck生产的Palbociclib (PD0332991) Isethionate发表文献209篇：

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产品安全说明书

CDK抑制剂选择性比较

生物活性

产品描述

特性

PD 0332991治疗多种癌症，特异性抑制CDK4/6，是第一种有前途的抑制剂。

靶点

CDK4/CyclinD3 ^[1] (Cell-free assay)	CDK4/CyclinD1 ^[1] (Cell-free assay)	CDK6/CyclinD2 ^[1] (Cell-free assay)
9 nM	11 nM	15 nM

体外研究

PD 0332991对CDK4/6具有绝对选择性，对其他CDKs几乎没有抑制活性。PD 0332991作用于MDA-MB-435乳腺癌细胞，有效降低Rb在Ser780 和 Ser795位点磷酸化，IC50分别为66 nM和63 nM。PD 0332991通过抑制细胞进入S期，有效抑制细胞生长，抑制 DNA复制。PD 0332991抑制胸苷渗透进Rb阳性人类乳腺癌(如MDA-MB-435, MCF-7), 结肠癌 (H1299), 和肺癌(Colo-205) 及白血病(CRRF-CEM和K562)的DNA中，IC50值为0.04-0.17 μM。PD 0332991显著增强MDA-MB-453在G1期的百分比。^[1]PD 0332991作用于CD138⁺原发性骨髓瘤细胞，初级非转化的B细胞，MM1.S和CAG HMCLs细胞系，抑制Rb磷酸化，IC50分别为 <0.1 μM, 0.05 μM, 和 60-70 nM。PD 0332991作用于CD138⁺原发性骨髓瘤细胞和初级非转化的B细胞，诱导细胞停滞在G1期。PD 0332991诱导MM1.S细胞停滞在G1期，IC50为~0.05 μM。^[2]PD 0332991优先抑制Luminal雌激素受体阳性(包括HER2阳性)人类乳腺癌细胞系。PD 0332991作用于大部分敏感的细胞系，促进pRb和cyclin D1基因表达，且降低CDKN2A(p16)基因表达。PD 0332991作用于条件性抗ER抑制的细胞系，增强对Tamoxifen的敏感性。^[3]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
H157	M{DrNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXi3NIN[OC1zMECg{txO	MVq3NkBp		NVKwWllNUUN3ME25JO69VQ>?	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjN7MEO0Nkc,OjZ\|OUCzOFI9N2F-
H2170	NFr5dWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVP6ZZlrOC1zMECg{txO	Mmq2O\|IhcA>?		NVrrepVjUUN3ME21JO69VQ>?	NHzoXWs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkO5NFM1Oid-Mk[zPVA{PDJ:L3G+
H520	NXK3SItGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1ni[lAuOTByIN88US=>	MVG3NkBp		NVvKZWs1UUN3ME2wMlc{KM7:TR?=	NV\yTYxORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zPVA{PDJpPkK2N\|kxOzR{PD;hQi=>
H596	MnjsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnzYNE0yODBizszN	M1fhNlczKGh?		MVnJR\|UxRTF{IN88US=>	M1qxe\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4M{mwN\|QzLz5{NkO5NFM1OjxxYU6=
IMR-32	NXnIWo9PT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		M1XCeVQ5yqCq	MVPEUXNQ	MojoTWM2OD1{NkGgcm0>	M1izdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MkK1NVI{Lz5{NkKyOVEzOzxxYU6=
SH-SY5Y	NYfZUFd2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NGPDWoo1QMLiaB?=	MnzFSG1UVw>?	NXX3UINKUUN3ME22O\|Yhdk1?	Ml3JQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ{MkWxNlMoRjJ4MkK1NVI{RC:jPh?=
NGP	NEG2c3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NH\TSlA1QMLiaB?=	NVXNcG1lTE2VTx?=	MV\JR\|UxRTJwMEe3JO69VQ>?	NEC2PVY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkKyOVEzOyd-Mk[yNlUyOjN:L3G+
SH-EP	Mnn5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NFr6Ooo1QMLiaB?=	NHjZbYhFVVOR	NUfkOmdyUUN3ME2yMlIyOSEQvF2=	M1jieFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MkK1NVI{Lz5{NkKyOVEzOzxxYU6=
IMR-32	MoHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NILWd4cyKM7:TR?=	MVWyOEBp	NFTEc\|FFVVOR	M2PGZolv\HWlZYOgS\|Eh[XK{ZYP0	NIHUeYQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkKyOVEzOyd-Mk[yNlUyOjN:L3G+
SH-SY5Y	M2m2UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUfUSnUyOSEQvF2=	NYjUS3JDOjRiaB?=	NXzmZ3FkTE2VTx?=	NYLVR5o4cW6mdXPld{BIOSCjcoLld5Q>	MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ{NUGyN{c,OjZ{MkWxNlM9N2F-
NGP	NWrPV5JpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFLWdIsyKM7:TR?=	NWHjNJhqOjRiaB?=	NH;RTVBFVVOR	NIf1S3RqdmS3Y3XzJGcyKGG{cnXzeC=>	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ{NUGyN{c,OjZ{MkWxNlM9N2F-
SH-EP	MkPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYCxJO69VQ>?	NUSzPYxiOjRiaB?=	MonYSG1UVw>?	MmDsbY5lfWOnczDHNUBienKnc4S=	MkLpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ{MkWxNlMoRjJ4MkK1NVI{RC:jPh?=
NGP	MonQSpVkfGmxbjDBd5NigQ>?	NVnFXpN7OC1zIN88US=>	NYTscYNOOjRiaB?=	NH\VeY9FVVOR	NVPHeWdRemWmdXPld{B1cGViZYjwdoV{e2mxbjDv[uKhXE:SMlGsxsBES06HMjygZY5lyqCWS{JCpIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy	NYnieoVZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[yNlUyOjNpPkK2NlI2OTJ\|PD;hQi=>
IMR-32	MU\GeYN1cW:wIFHzd4F6	MXywMVEh\|ryP	M1vHXlI1KGh?	MW\EUXNQ	NWm3TVF6emWmdXPld{B1cGViZYjwdoV{e2mxbjDv[uKhXE:SMlGsxsBES06HMjygZY5lyqCWS{JCpIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy	MnfNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ{MkWxNlMoRjJ4MkK1NVI{RC:jPh?=
U-CH2	MmLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlXoNE0yKM7:TR?=	NVz0TIN7PzJiaB?=		MmP3TWM2OD13MD6yJI5O	NFS1[4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkG4N\|kzPSd-Mk[xPFM6OjV:L3G+
U-CH3	MlS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXrzOpdbOC1zIN88US=>	MV63NkBp		NWnhPVdKUUN3ME21NkBvVQ>?	M2CxVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MUizPVI2Lz5{NkG4N\|kzPTxxYU6=
U-CH6	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHHxb\|IxNTFizszN	NWfoNZdJPzJiaB?=		MkXlTWM2OD17MDDuUS=>	MmTtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzOEO5NlUoRjJ4MUizPVI2RC:jPh?=
U-CH7	M3XsXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXewMVEh\|ryP	NXnMN3pDPzJiaB?=		NHraemtKSzVyPUm4JI5O	MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF6M{myOUc,OjZzOEO5NlU9N2F-
U-CH11	NX7tN2MyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYewMVEh\|ryP	NYLXOZFKPzJiaB?=		MWLJR\|UxRTN2MDDuUS=>	M4TQflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MUizPVI2Lz5{NkG4N\|kzPTxxYU6=
MCF7	MXjGeYN1cW:wIFHzd4F6	NGPZVpUzNjVvMkWwJI5O	MmnTNlQhcA>?		NFXoNG1z\WS3Y3XzJHJjKHCqb4PwbI9zgWyjdHnvci=>	M1G2TlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUmxPFE4Lz5{NUm5NVgyPzxxYU6=
MV4-11	MX3BdI9xfG:\|aYOgRZN{[Xl?	NHLxfJcxNjVizszN	NILlNYozPCCq		NYmxfVJx\W6qYX7j[ZMh[XCxcITvd4l{KGmwZIXj[YQh[nlic3;yZYZmdmmkIHHu[EBCSzJ{MB?=	NYCwdpdyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW0PFc6OTdpPkK1OFg4QTF5PD;hQi=>
MOLM13	M{O5NWFxd3C2b4Ppd{BCe3OjeR?=	NHHueVgxNjVizszN	NGjCfmQzPCCq		NUi3T\|RK\W6qYX7j[ZMh[XCxcITvd4l{KGmwZIXj[YQh[nlic3;yZYZmdmmkIHHu[EBCSzJ{MB?=	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR6N{mxO{c,OjV2OEe5NVc9N2F-
MOLM13-ITD alone	NIG1cYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXvJR\|UxRTBwMEi5JOKyKDBwMEC5JO69VQ>?	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR6N{mxO{c,OjV2OEe5NVc9N2F-
MV4-11-ITD alone	Mo\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NWfHVXNkUUN3ME2wMlA6OiEEsTCwMlAxQCEQvF2=	MoezQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2OEe5NVcoRjJ3NEi3PVE4RC:jPh?=
MOLM13-ITD/D835Y	M{LCN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NYDFdHQ3UUN3ME2wMlEyPCEEsTCwMlAyOSEQvF2=	NWP6fVNNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW0PFc6OTdpPkK1OFg4QTF5PD;hQi=>
MV4-11-ITD/D835V	NIOzW2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4q1N2lEPTB;MD6xNVYhyrFiMD6wNVEh\|ryP	Ml;PQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2OEe5NVcoRjJ3NEi3PVE4RC:jPh?=
MV4-11-ITD/D835V	NUHSNmtTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1jtVmlEPTB;MD6xNFIhyrFiMD6wNFYh\|ryP	M3zBTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NEi3PVE4Lz5{NUS4O\|kyPzxxYU6=
MV4-11-ITD/F691L	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NV\jXGNuUUN3ME2wMlEyOiEEsTCwMlAyPSEQvF2=	NG\IZWc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUS4O\|kyPyd-MkW0PFc6OTd:L3G+
MV4-11-ITD/N841K	NFW5NYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NHjO[IpKSzVyPUCuNVE{KMLzIECuNFAzKM7:TR?=	Mn3YQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2OEe5NVcoRjJ3NEi3PVE4RC:jPh?=
U937-FLT3 WT	NGDnZZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NV7pPFQyUUN3ME2wMlExOiEEsTCwMlAyOyEQvF2=	MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR6N{mxO{c,OjV2OEe5NVc9N2F-
P12-ICHIKAWA	MlHCS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				MmT2TWM2OCB;IECuNFk3ODRizszN	MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
697	M{DlcWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				MYfJR\|UxKD1iMD6xOFg{QCEQvF2=	M{LNbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
NB69	NH\HTlJIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				MVvJR\|UxKD1iMD6xOlE5KM7:TR?=	M{G1WlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
EoL-1-cell	NID6S3hIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				NGrIWodKSzVyIE2gNE4yQDd{NjFOwG0>	M{jPZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
BHT-101	NFT1XFVIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				MmjETWM2OCB;IECuNVk5OjVizszN	MkizQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
SK-NEP-1	NYXjfm8zT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				NVPnS3ZKUUN3MDC9JFAvOjJyMEKg{txO	NWP5O4V7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
MHH-NB-11	NYXxVYVlT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				NV3zW\|g5UUN3MDC9JFAvOjJyMUmg{txO	MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
AsPC-1	NFrS[WRIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				Ml;0TWM2OCB;IECuNlUzPTNizszN	NY\qbGJNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
ES1	MX3Hdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				NGPJPJBKSzVyIE2gNE4zPTZ{NTFOwG0>	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
LAMA-84	NXe3emhvT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				Ml3STWM2OCB;IECuNlU5OTlizszN	NVOyNItTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
MOLT-16	M2LwOWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				NIj5fJlKSzVyIE2gNE4zPTh2OTFOwG0>	M3joeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
ES7	MYLHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				NFvLbXJKSzVyIE2gNE4zPzNyOTFOwG0>	M{nuWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
KY821	MlXnS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				M2\ZdmlEPTBiPTCwMlMyPDFizszN	NFfSXoE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
RT-112	NYewTHBiT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				MmPITWM2OCB;IECuN\|IyODVizszN	M4XDVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
HL-60	NYjLNmIzT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				MWjJR\|UxKD1iMD6zOFA3PiEQvF2=	M12z[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
MOLT-4	Mn3GS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				MUXJR\|UxKD1iMD6zOFUyOyEQvF2=	MlH5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
KARPAS-45	MX3Hdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				M3rQO2lEPTBiPTCwMlM4PjF4IN88US=>	MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
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Mewo	MnXpS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				NX3V[2I5UUN3MDC9JFAvQTN4NjFOwG0>	NYjP[HhGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
NCI-H1770	NXzmOnNQT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				NXvpcI03UUN3MDC9JFAvQTRyNUWg{txO	NInjNVg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
HO-1-N-1	MUTHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				MXvJR\|UxKD1iMD65OlI5OSEQvF2=	MmrCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
HSC-3	NHTlPVhIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				MmXHTWM2OCB;IECuPVY3PDhizszN	M{\NUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
TYK-nu	NFL3WW1Iem:5dHigTY5pcWKrdHnvckBie3OjeR?=				M4nJVGlEPTBiPTCwMlk6QDJ3IN88US=>	NFTVcnA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
KYSE-150	NF7ZXJVIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				NVXsXmVKUUN3MDC9JFEvODByN{[g{txO	MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
SN12C	NF;GbFRIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				Mne5TWM2OCB;IEGuNFA5PzVizszN	M{\jNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
MOLT-13	MmrIS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				NXfHSVhpUUN3MDC9JFEvODF2MkGg{txO	MoTTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
TE-11	M3q3Tmdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				MXXJR\|UxKD1iMT6wOFgyOiEQvF2=	M1zRO\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
DB	M3nNZWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				NU[0VVZyUUN3MDC9JFEvODd{N{Og{txO	M4DjdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
CAL-39	M{jibWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				MUPJR\|UxKD1iMT6wO\|UzOiEQvF2=	NIDwS4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
A3-KAW	NIn4WGlIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				MXLJR\|UxKD1iMT6wPFQxQCEQvF2=	NHzjfXc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
CHP-134	NYrFZnB7T3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				NWLteVlzUUN3MDC9JFEvOTF6MEeg{txO	NUnscIRiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
TGW	MXXHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				NI\Rd4FKSzVyIE2gNU4yOjN7NTFOwG0>	MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
QIMR-WIL	MXXHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				MXXJR\|UxKD1iMT6xN\|E{PCEQvF2=	MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
NCI-SNU-1	Mn;KS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				M1zz[GlEPTBiPTCxMlE3OzV2IN88US=>	MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
CGTH-W-1	Mn;JS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				NEfHUoNKSzVyIE2gNU4yPzF6NjFOwG0>	NV7DTIk{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
MHH-ES-1	MWHHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				MVTJR\|UxKD1iMT6xO\|k5PiEQvF2=	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
LB2241-RCC	NE\wbI5Iem:5dHigTY5pcWKrdHnvckBie3OjeR?=				NYXH[mc1UUN3MDC9JFEvOTh4MjFOwG0>	M4jD[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
ML-2	MWjHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				MWHJR\|UxKD1iMT6yNFc{PCEQvF2=	Ml2yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
COR-L23	NFfPc29Iem:5dHigTY5pcWKrdHnvckBie3OjeR?=				M{DodGlEPTBiPTCxMlIzQTN\|IN88US=>	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
BFTC-905	NF\4VmpIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				MkLsTWM2OCB;IEGuNlQzPjdizszN	NIjz[FA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
Hs-578-T	MVrHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				MYDJR\|UxKD1iMT6yOVgyPyEQvF2=	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
KG-1	M4P1R2dzd3e2aDDJcohq[mm2aX;uJIF{e2G7				MlvuTWM2OCB;IEGuNlY3QDZizszN	NWTvdFJNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
HEL	MnPVS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				MnPqTWM2OCB;IEGuNlk{OzhizszN	M4LVT\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
A549	MYrHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				MmDOTWM2OCB;IEGuNlk{QTlizszN	NVT6UItFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
COLO-741	MWXHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				NWHkSm1KUUN3MDC9JFEvOzJyOEmg{txO	MoHTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
PC-3	NWLxdVRkT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				M{DJeWlEPTBiPTCxMlM2OjJzIN88US=>	NFXOZW89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
HOS	MlPpS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				NFvXb4pKSzVyIE2gNU4{PTJ7NjFOwG0>	M3jCS\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
HT-1080	M1;hb2dzd3e2aDDJcohq[mm2aX;uJIF{e2G7				MlvSTWM2OCB;IEGuN\|c2OTlizszN	Mm\xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
TE-8	M2nHOWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				M4HBcWlEPTBiPTCxMlQyPzd2IN88US=>	NXvDW5h3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
BHY	MULHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				MkTFTWM2OCB;IEGuOFY6OjNizszN	MnjyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
BB65-RCC	MlPmS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				M2W5bmlEPTBiPTCxMlUxPTJ6IN88US=>	NV7ieY1PRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
HN	NWHUSWJ[T3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				M2HkRmlEPTBiPTCxMlU1ODdzIN88US=>	M1jYTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
NCI-H441	M13GSmdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				MYPJR\|UxKD1iMT61OFkxPyEQvF2=	NGTkVmk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
RPMI-8866	M3\ObWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				NWrjfGo4UUN3MDC9JFEvPTh3MEeg{txO	MoW0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
CAL-62	NYDDfnZtT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				M3\uWGlEPTBiPTCxMlYxQDZ{IN88US=>	MmHzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
MG-63	MWDHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				MXPJR\|UxKD1iMT62NVgyOyEQvF2=	MkLWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
SK-LU-1	M3rodWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				M4LneWlEPTBiPTCxMlYzOTV{IN88US=>	NF\EU3o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
BCPAP	MonFS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				M3zufmlEPTBiPTCxMlY3PDV5IN88US=>	NHPtW4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
22RV1	M2LH[Wdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				NV;udWhKUUN3MDC9JFEvPjd6NEOg{txO	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
T47D	M3Pte2dzd3e2aDDJcohq[mm2aX;uJIF{e2G7				M2\jNWlEPTBiPTCxMlY5ODZzIN88US=>	M2HKd\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
MSTO-211H	Mm\2S5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				NXnSXXEyUUN3MDC9JFEvPjl4MEOg{txO	MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
DEL	NG[wOG1Iem:5dHigTY5pcWKrdHnvckBie3OjeR?=				NFTMcJpKSzVyIE2gNU44ODJ5MzFOwG0>	MkPVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
H4	NXzXOoNlT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				M{nIT2lEPTBiPTCxMlc{OjF{IN88US=>	NHX2eYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
CAL-51	MmXZS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				M4XwbWlEPTBiPTCxMlc1QDV3IN88US=>	MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
ABC-1	NH;wSldIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				MX3JR\|UxKD1iMT63PFU5OiEQvF2=	M1XWPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
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CAL-120	NYT1Z4l3T3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				NHPJTZNKSzVyIE2gNVMvPjdzODFOwG0>	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
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COLO-678	NUW0dpNDT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				NVXw[2JzUUN3MDC9JFE1NjB6MkKg{txO	MkfpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
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KINGS-1	NFjz[WRIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				NHe5UIZKSzVyIE2gNVQvOTRyMjFOwG0>	Mn;iQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
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KYSE-140	NEe3fYhIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				M3XwcGlEPTBiPTCxOE43OzJ5IN88US=>	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
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COLO-679	MkLaS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				MkC2TWM2OCB;IEG1Mlc3QDNizszN	M2fYVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
UACC-257	MWHHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				MmToTWM2OCB;IEG2MlEzODFizszN	NGWz[II9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
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NCI-H2170	MoDhS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				NHzFTodKSzVyIE2gNVcvOjR2ODFOwG0>	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
AGS	NXzpXoJTT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				NITjZ\|ZKSzVyIE2gNVcvOzhyODFOwG0>	NFXVUXY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
MEL-HO	MkHGS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				MXXJR\|UxKD1iMUeuO\|UxOyEQvF2=	M1LwdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
SW48	MojhS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				NWGwO3ZPUUN3MDC9JFE4Njd5MU[g{txO	NVjVU\|N4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
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NCI-H720	MWnHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				NWjCVI9NUUN3MDC9JFE5NjF2MEKg{txO	M4\yXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
RCC10RGB	Mn[zS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				MUjJR\|UxKD1iMUiuNVY6PyEQvF2=	M{fWRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
HD-MY-Z	NH22SpZIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				NV\NcIw2UUN3MDC9JFE5NjJ{NUSg{txO	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
A427	MorqS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				MnnlTWM2OCB;IEG4MlUxQTRizszN	NHzWXFc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
HCC2998	NVi2[phNT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=				NHfGfFNKSzVyIE2gNVgvPjB3MTFOwG0>	NF3WZVM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
EPLC-272H	MWrHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				NGfHco5KSzVyIE2gNVkvODR\|NDFOwG0>	NIrkXYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
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UMC-11	MkjxS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				NXTQUZlKUUN3MDC9JFE6NjJzMkOg{txO	MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
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KYSE-410	M{HscGdzd3e2aDDJcohq[mm2aX;uJIF{e2G7				M1vnVGlEPTBiPTCxPU46OTN7IN88US=>	Mon2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
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LB996-RCC	NEW2dYtIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				MkPPTWM2OCB;IEKwMlcyPjhizszN	NYT5WGd{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
KYSE-70	Mn3PS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				NGDhSVJKSzVyIE2gNlAvQDB3OTFOwG0>	NGq4Zms9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
CAL-72	MWPHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?				NUn4SpprUUN3MDC9JFIxNjlzNTFOwG0>	NEjWT449[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
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BB49-HNC	M3zRN2dzd3e2aDDJcohq[mm2aX;uJIF{e2G7				NU\1ZZFzUUN3MDC9JFIyNjV5MU[g{txO	NFe1SHM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
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BALL-1	NEDJ[4tIem:5dHigTY5pcWKrdHnvckBie3OjeR?=				MlzhTWM2OCB;IEK2Mlk{QTdizszN	M3\lZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
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PFSK-1	Ml21S5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?				NUnaRZdEUUN3MDC9JFU{Oi57NEGg{txO	NWTOV4hORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
MOLM13	NHv1e3lHfW6ldHnvckBie3OjeR?=		NFnUSIczPCCqcoO=		M{j4NmlvcGmkaYTpc44hd2ZiQ1TLOEBqdiCqdX3hckBOV0yPMUOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCUYjDwbI9{eGixconsZZRqd25iYYSgV4VzPzhyIHHmeIVzKDJ2IHjyd{whUUN3MDC9JFAvODFzIN88UU4>	MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ2MUGwN{c,OjR4NEGxNFM9N2F-
COLO205	NGjBXY5CdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		M{ThfFczKGi{cx?=		M2DvTWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgVoIueG:\|aYTpeoUhcHWvYX6gR29NVzJyNTDj[YxteyCjc4Pld5Nm\CCjczDpcoNwenCxcnH0bY9vKG:oIGuzTH11cHmvaXTpcoUhcW62bzDEUmEh[W[2ZYKgO\|IhcHK\|IHL5JIJmfGFvcHzheIUh[2:3boTpcoch[W6jbInzbZMtKEmFNUCgQUAxNjB\|NjFOwG0v	NGrZVYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[0NVExOyd-MkS2OFEyODN:L3G+
MOLM13	Ml3SRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NFTRdIc4OiCqcoO=		MmDRRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCPT1zNNVMh[2WubIOgbIFz[m:{aX7nJGZNXDNiSWTEJI12fGGwdDDhd5Nme3OnZDDhd{BqdmOxcoDvdoF1cW:wIH;mJHs{UF22aIntbYRqdmViaX70c{BFVkFiYX\0[ZIhPzJiaILzJIJ6KGKndHGtdIxifGViY3;1cpRqdmdiYX7hcJl{cXNuIFnDOVAhRSByLkC5OkDPxE1w	NXrTb4FRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2OFEyODNpPkK0OlQyOTB\|PD;hQi=>
MOLM13	M1TJRWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MVu3NkBpenN?		NYXyOFI4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEB{d3KjZnXubYIuemW\|aYP0ZY51KGi3bXHuJG1QVE1zMzDj[YxteyCjc4Pld5Nm\CCjczDpcoNwenCxcnH0bY9vKG:oIGuzTH11cHmvaXTpcoUhcW62bzDEUmEh[W[2ZYKgO\|IhcHK\|IHL5JIJmfGFvcHzheIUh[2:3boTpcoch[W6jbInzbZMtKEmFNUCgQUAxNjB7NjFOwG0v	NFvYS489[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[0NVExOyd-MkS2OFEyODN:L3G+
U937	MorsRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NIPrZY44OiCqcoO=		MVfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFV7M{egZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kd3Kyb4LheIlwdiCxZjDbN2hefGi7bXnkbY5mKGmwdH:gSG5CKGGodHXyJFczKGi{czDifUBj\XSjLYDsZZRmKGOxdX70bY5oKGGwYXz5d4l{NCCLQ{WwJF0hOC5zNDFOwG0v	NYfReJN3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2OFEyODNpPkK0OlQyOTB\|PD;hQi=>
insect cell	MWXGeY5kfGmxbjDhd5NigQ>?		MYKyJI1qdnN?		MlywTY5pcWKrdHnvckBw\iCFRFu2M4N6[2yrbjDENkApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCkYXP1cI93cXK3czDpcoZm[3SnZDDpcpNm[3RiY3XscJMhfXOrbnegS3NVNW[3c3XkJJBT[iBqN{myJJRwKDl{ODmgZZMhe3Wkc4TyZZRmKHC{ZXnuZ5Vj[XSnZDDmc5IhOiCvaX7zJIZwdGyxd3XkJIJ6KFupYX3tZU0{OlCfLVHUVEBi\GSrdHnvckBu\WG\|dYLl[EBi\nSncjCxOUBucW6\|IHL5JIJmfGFicHzheIUh[2:3boTpcoch[W6jbInzbZMtKEmFNUCgQUAxNjByOTFOwG0v	MkLNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzMUW1O\|EoRjJ4MUG1OVcyRC:jPh?=
insect cell	Ml\USpVv[3Srb36gZZN{[Xl?		MXmyJI1qdnN?		NILE[FFKdmirYnn0bY9vKG:oIFPET\|Yw[3mlbHnuJGQzKCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIHLhZ5Vtd3[rcoXzJIlv\mWldHXkJIlve2WldDDj[YxteyC3c3nu[{BIW1RvZoXz[YQheFKkIDi3PVIhfG9iOUK4LUBieyC\|dXLzeJJifGVicILlbY5kfWKjdHXkJIZweiB{IH3pcpMh\m:ubH;3[YQh[nliW3fhcY1iNTN{UG2tRXRRKGGmZHn0bY9vKG2nYYP1doVlKGGodHXyJFE2KG2rboOgZpkh[mW2YTDwcIF1\SClb4XueIlv\yCjbnHsfZNqeyxiSVO1NEA:KDBwMEC5JO69VS5?	NIDNW3o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkGxOVU4OSd-Mk[xNVU2PzF:L3G+
insect cell	M1O5TmZ2dmO2aX;uJIF{e2G7		M2ftW\|IhdWmwcx?=		NWnxV3l1UW6qaXLpeIlwdiCxZjDDSGs1N2O7Y3zpckBFOSBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDiZYN2dG:4aYL1d{Bqdm[nY4Tl[EBqdnOnY4SgZ4VtdHNidYPpcochT1OWLX\1d4VlKHCUYjCoO\|kzKHSxIEmyPEkh[XNic4Xid5Rz[XSnIIDy[Ylv[3WkYYTl[EBnd3JiMjDtbY5{KG[xbHzve4VlKGK7IGvnZY1u[S1\|MmDdMWFVWCCjZHTpeIlwdiCvZXHzeZJm\CCjZoTldkAyPSCvaX7zJIJ6KGKndHGgdIxifGViY3;1cpRqdmdiYX7hcJl{cXNuIFnDOVAhRSByLkCxNUDPxE1w	MlvZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzMUW1O\|EoRjJ4MUG1OVcyRC:jPh?=
insect cell	NELQNoZHfW6ldHnvckBie3OjeR?=		MUeyJI1qdnN?		Mn;STY5pcWKrdHnvckBw\iCFRFu0M4N6[2yrbjDENUApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCkYXP1cI93cXK3czDpcoZm[3SnZDDpcpNm[3RiY3XscJMhfXOrbnegS3NVNW[3c3XkJJBT[iBqN{myJJRwKDl{ODmgZZMhe3Wkc4TyZZRmKHC{ZXnuZ5Vj[XSnZDDmc5IhOiCvaX7zJIZwdGyxd3XkJIJ6KFupYX3tZU0{OlCfLVHUVEBi\GSrdHnvckBu\WG\|dYLl[EBi\nSncjCxOUBucW6\|IHL5JIJmfGFicHzheIUh[2:3boTpcoch[W6jbInzbZMtKEmFNUCgQUAxNjBzMTFOwG0v	NVrzcHJjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xNVU2PzFpPkK2NVE2PTdzPD;hQi=>
MDA-MB-435	NGrRbGVCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MVKyOEBpenN?		MnrTRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDSZk1xd3OrdHn2[UBpfW2jbjDNSGEuVUJvNEO1JINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiW{G0R30ufGi7bXnkbY5mKGmwY3;ydI9z[XSrb36gbY51dyCGTlGgdJJmcW6ldXLheIVlKG[xcjCyOEBpenNiZn;scI94\WRiYomgX\|E1S11vdHj5cYllcW6nIHHk[Il1cW:wIH3lZZN2emWmIHHmeIVzKDd{IHjyd{BjgSCkZYThJJBt[XSnIHPveY51cW6pIHHuZYx6e2m\|LDDJR\|UxKD1iMD6xOkDPxE1w	NUHUc4ZNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xNVU2PzFpPkK2NVE2PTdzPD;hQi=>
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sf9	Ml;TSpVv[3Srb36gZZN{[Xl?				NFrrUohKdmirYnn0bY9vKG:oIFPET\|IwS3mlbHnuJGUhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5ic3[5JINmdGy\|IIXzbY5oKGirc4TvcoUhUDFiYYOgd5Vje3S{YYTlJIlvKHC{ZYPlcoNmKG:oIGvnZY1u[TN\|UG2tRXRRNCCLQ{WwJF0hQS5{IN88UU4>	MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjh3MUWwOUc,OjZ6NUG1NFU9N2F-
insect cell	NVOwfHFQTnWwY4Tpc44h[XO\|YYm=		M{P2WVIhdWmwcx?=		MVPJcohq[mm2aX;uJI9nKEOGS{SvZ5lkdGmwIFSxJEh2dmuwb4fuJI9zcWerbjmg[ZhxemW\|c3XkJIlvKGKjY4Xsc5ZqenW\|IHnu[oVkfGWmIHnud4VkfCClZXzsd{B2e2mwZzDHV3QufGGpZ3XkJJBTSiBqN{myJJRwKDl{ODDy[ZNq\HWnczmgZZMhe3Wkc4TyZZRmKHC{ZXnuZ5Vj[XSnZDDmc5IhOiCvaX7zJIZwdGyxd3XkJIJ6KFupYX3tZVMzWF2DVGCgZYRlcXSrb36gcYVie3W{ZXSgZYZ1\XJiMUWgcYlveyCkeTDi[ZRiKGOxdX70bY5oKG2ndHjv[EwhUUN3MDC9JFAvODFzIN88UU4>	MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzF5MUCzOkc,OjdzN{GwN\|Y9N2F-
insect cell	M2q4OGZ2dmO2aX;uJIF{e2G7		NELHVFgzKG2rboO=		NVTUOpZqUW6qaXLpeIlwdiCxZjDDSGs1N2O7Y3zpckBFOSBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDiZYN2dG:4aYL1d{Bqdm[nY4Tl[EBqdnOnY4SgZ4VtdHNidYPpcochT1OWLYTh[4dm\CCyUlKgLFc6OiC2bzC5NlghemW\|aXT1[ZMqKGG\|IIP1ZpN1emG2ZTDwdoVqdmO3YnH0[YQh\m:{IEKgcYlveyCob3zsc5dm\CCkeTDb[4FudWF\|MmDdRXRRKGGmZHn0bY9vKG2nYYP1doVlKGGodHXyJFE2KG2rboOgZpkh[mW2YTDjc5VvfGmwZzDt[ZRpd2RuIFnDOVAhRSByLkCxNUDPxE1w	MlHwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzN{GwN\|YoRjJ5MUexNFM3RC:jPh?=
insect cell	NX3ZbmNGTnWwY4Tpc44h[XO\|YYm=		MmfiNkBucW6\|		NHv1N2xKdmirYnn0bY9vKG:oIFPET\|Yw[3mlbHnuJGQzKCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIHLhZ5Vtd3[rcoXzJIlv\mWldHXkJIlve2WldDDj[YxteyC3c3nu[{BIW1RvdHHn[4VlKHCUQjCoO\|kzKHSxIEmyPEBz\XOrZIXld{kh[XNic4Xid5Rz[XSnIIDy[Ylv[3WkYYTl[EBnd3JiMjDtbY5{KG[xbHzve4VlKGK7IGvnZY1u[TN{UG3BWHAh[WSmaYTpc44hdWWjc4Xy[YQh[W[2ZYKgNVUhdWmwczDifUBj\XSjIHPveY51cW6pIH3leIhw\CxiSVO1NEA:KDBwMEG1JO69VS5?	NFm3U2I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{G3NVA{Pid-MkexO\|ExOzZ:L3G+
insect cell	NWDBNZVjTnWwY4Tpc44h[XO\|YYm=		NUTWR5VTOiCvaX7z		NXPwemYxUW6qaXLpeIlwdiCxZjDDSGs3N2O7Y3zpckBFOiBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDiZYN2dG:4aYL1d{Bqdm[nY4Tl[EBqdnOnY4SgZ4VtdHNidYPpcochT1OWLYTh[4dm\CCyUlKgLFc6OiC2bzC5NlghemW\|aXT1[ZMqKGG\|IIP1ZpN1emG2ZTDwdoVqdmO3YnH0[YQh\m:{IEKgcYlveyCob3zsc5dm\CCkeTDb[4FudWF\|MmDdRXRRKGGmZHn0bY9vKG2nYYP1doVlKGGodHXyJFE2KG2rboOgZpkh[mW2YTDjc5VvfGmwZzDt[ZRpd2RuIFnDOVAhRSByLkCxOUDPxE1w	MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzF5MUCzOkc,OjdzN{GwN\|Y9N2F-
MDA-MB-453	MmPhR5l1d3SxeHnjbZR6KGG\|c3H5		MnjaOFghcHK\|		MXjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvNEWzJINmdGy\|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgR2NMQCCjc4PhfUwhUUN3MDC9JFAvOTN5IN88UU4>	MnzEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd2NEi5NVMoRjJ5NES4PVE{RC:jPh?=
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BT-37	NXzscWNleUiWUzDhd5NigQ>?				NYD0O2tueUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IFLUMVM4KGOnbHzz	NGLNZVY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
RD	NEHacFRyUFSVIHHzd4F6				M2nSVJFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCURDDj[Yxtew>?	NXfRdJlwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
SK-N-SH	NEjISnJyUFSVIHHzd4F6				MYnxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhW0tvTj3TTEBk\Wyucx?=	M{LsRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
NB1643	MV\xTHRUKGG\|c3H5				MVPxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhVkJzNkSzJINmdGy\|	NEjUe3k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
OHS-50	NWjQVWFVeUiWUzDhd5NigQ>?				M2\GV5FJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCRSGOtOVAh[2WubIO=	MmS0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
SK-N-MC	NIPnXnFyUFSVIHHzd4F6				NWG5Rll[eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IGPLMW4uVUNiY3XscJM>	Mkm1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
NB-EBc1	M3r6VJFJXFNiYYPzZZk>				NGraUnZyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiTlKtSWJkOSClZXzsdy=>	NHjrRZk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
LAN-5	MYfxTHRUKGG\|c3H5				M3joOpFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCOQV6tOUBk\Wyucx?=	NXXGPVR7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
Rh18	NY\CWGtpeUiWUzDhd5NigQ>?				M4XGeZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCUaEG4JINmdGy\|	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	RB1 (pT821) / RB1 (pS780); PubMed: 30300583 Cancer cell Immunoblots showing dose-dependent impact of 72 hr palbociclib treatment on indicated protein levels in Kasumi-1 and SKNO-1 cells. pAMPKα(T172) / AMPKα; PubMed: 28453226 Mol Oncol Dose-dependent response of palbociclib on AMPK‐related molecules. HCC cells were treated with different concentrations of palbociclib for 24 h. The phosphorylation of the indicated proteins was determined by western blotting. pULK1(S317) / ULK1; PubMed: 28453226 Mol Oncol Dose-dependent response of palbociclib on AMPK‐related molecules. HCC cells were treated with different concentrations of palbociclib for 24 h. The phosphorylation of the indicated proteins was determined by western blotting. c-Jun / p-c-Jun / NFκB(p50); PubMed: 26540629 Oncotarget The expression of c-Jun and phosphorylated c-Jun was assessed using western blot after the cells were treated with palbociclib. p38 / p-P38 / JNK / p-JNK; PubMed: 26540629 Oncotarget MAPK pathway-related proteins, p38, ERK, JNK expression levels were detected.	30300583 28453226 26540629
Growth inhibition assay	Cell viability; PubMed: 28453226 Mol Oncol Dose- and time-dependent effects of palbociclib on cell viability in three HCC cell lines. Hep3B, Huh7, and PLC5 cells were treated with palbociclib at the indicated concentrations for 24 or 48 h and assayed by MTT. The solvent (DMSO) concentration in each sample is equal (0.7%). IC50; PubMed: 27099147 Blood Dose-response curve of ITD+ (red) or control (black) leukemic cells with CDK4/6 inhibitor palbociclib. Cells were incubated with increasing concentrations for 72 hours. Cell viability and proliferation were assessed by using the CTG assay. IC50 values were calculated by using GraphPad Prism software. Error bars indicate ± SEM.	28453226 27099147
Immunofluorescence	γH2AX(Ser139); PubMed: 29669860 EMBO J Representative maximum‐intensity projections of MCF7 cells treated with the 1 μM palbociclib and/or 7.5 nM bortezomib. Note that 7.5 nM bortezomib inhibits proteasome only partially. Fixed and permeabilized cells were stained with Alexa Fluor 488‐conjugated Ki67 antibody, Alexa Fluor 647‐conjugated phospho‐Histone H2A.X (γH2AX) (pSer139) antibody, and DAPI. All images were acquired with the same magnification, and scale bar is 20 μm. LC3B; PubMed: 28453226 Mol Oncol LC3B immunofluorescence in palbociclib‐treated Hep3B cells. Arrowheads indicate LC3‐positive autophagosomes. Nuclei were counterstained with DAPI (blue).	29669860 28453226
ELISA	PGE2; PubMed: 26540629 Oncotarget The supernatant of control and 7.5 μM palbociclib-treated cells was collected and stored at −80°C. PGE2 secretion was detected using ELISA.	26540629

体内研究

PD 0332991(150 mg/kg)作用于Colo-205结肠癌移植瘤，诱导肿瘤快速衰退，肿瘤生长相应延迟。PD 0332991(150 mg/kg)作用于MDA-MB-435乳腺癌，诱导全部肿瘤停滞和杀死细胞。PD 0332991(150 mg/kg)处理携带SF-295胶质母细胞瘤，和ZR-75-1乳腺癌和PC-3前列腺肿瘤模型(完全抑制肿瘤生长)的小鼠，显著诱导肿瘤衰退。PD 0332991 (150 mg/kg)处理 MDA-MB-435乳腺癌超过24小时，抑制Rb在Ser⁷⁸⁰位点磷酸化。PD 0332991(150 mg/kg)处理Colo-205 移植瘤，下调四种E2F调节的基因CDC2, CCNE2, TK1, 和 TOP2A表达。^[1]PD 0332991也快速抑制骨髓瘤生长。^[2]

激酶实验：^[4]	- 合并 CDK活性实验: 在96孔过滤板中进行动力学测评，测定CDK实验的IC50值。所有的CDK-cyclin激酶复合物在昆虫细胞中通过杆状病毒感染而表达，并进行纯化。实验底物是与GST(GST•RB-Cterm)融合的pRb组分(792–928位氨基酸)。总反应体积为0.1 mL，包含终浓度20 mM Tris-HCl,pH 7.4, 50 mM NaCl,1 mM 二硫苏糖醇,10 mM MgCl₂，含0.25 μCi[γ-³²P]ATP的25 μM ATP(作用于 CDK4-cyclin D1, CDK6-cyclin D2, 和 CDK6-cyclin D3), 20 ng 酶, 1 μg GST•RB-Cterm, 及适度稀释的抑制剂。每孔加入全部组分，除了[γ-³²P]ATP，置于混合器中2分钟。加入[γ-³²P]ATP开始反应,在25°C下温育15分钟。加入0.1 mL 20% 三氯乙酸终止反应, 实验板置于4°C至少1小时，使底物沉淀。每孔使用 0.2 mL 10%三氯乙酸洗涤五次，使用β计数器测定渗透的放射性。
细胞实验：^[3]	- 合并 Cell lines: 人类乳腺癌细胞MDA-MB-435 Concentrations: 2 μM Incubation Time: 6 天 Method: 细胞按一式两份每孔5,000 到10,000个细胞接种在24孔板中，接种后，加入不同浓度的PD 0332991。对照组不加入药物。温育末期，细胞胰蛋白酶化，并置于等渗溶液中，并立即使用Coulter Z2粒子计数器计数。 (Only for Reference)
动物实验：^[1]	- 合并 Animal Models: 人类结肠癌移植瘤Colo-205 Dosages: 150 mg/kg Administration: 每天口服处理 (Only for Reference)

参考文献

[4] Fry DW, et al. J Biol Chem, 2001, 276(20), 16617-16623.

- 合并

溶解度 (25°C)

体外	Water	10 mg/mL warmed (17.43 mM)
	DMSO	Insoluble
	Ethanol	Insoluble
体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： saline (with warming)	10mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download Palbociclib (PD0332991) Isethionate SDF

分子量	573.66
化学式	C₂₄H₂₉N₇O₂.C₂H₆O₄S
CAS号	827022-33-3
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	N/A

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

临床试验信息 (data from https://clinicaltrials.gov, updated on 2021-05-17)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04841148	Not yet recruiting	Drug: HCQ\|Drug: Avelumab\|Drug: Palbociclib	Breast Cancer	Abramson Cancer Center of the University of Pennsylvania\|Johns Hopkins University\|Translational Breast Cancer Research Consortium\|Pfizer\|Breast Cancer Research Foundation	May 2021	Phase 2
NCT04735367	Not yet recruiting	Drug: palbociclib plus letrozole	Breast Cancer	Pfizer	February 1 2021	--
NCT04654208	Recruiting	Drug: palbociclib	Malignant Neoplasm of Breast	Pfizer	December 15 2020	--
NCT04360941	Recruiting	Drug: Palbociclib\|Drug: Avelumab	Triple Negative Breast Cancer\|Locally Advanced Breast Cancer\|Recurrent Breast Cancer\|Metastatic Breast Cancer\|ER+ Breast Cancer\|HER2-positive Breast Cancer	Royal Marsden NHS Foundation Trust\|Pfizer\|Breast Cancer Now	August 11 2020	Phase 1

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

常见问题及建议解决方法

问题 1：
What is the best vehicle for palbociclib for in vitro and in vivo?
回答：
You can use water for vitro use and Saline for vivo use.

CDK Signaling Pathway Map

CDK Inhibitors with Unique Features

选择性强的CDK抑制剂

BS-181 HCl : CDK7-selective, IC50=21 nM.
选择性强的CDK抑制剂

SNS-032 (BMS-387032) : CDK2-selective, IC50=48 nM.
活性最高的CDK抑制剂

LY2835219 : CDK4, IC50=2 nM; CDK6, IC50=10 nM.
用于临床的CDK抑制剂

Dinaciclib (SCH727965) : Phase III for Chronic Lymphocytic Leukemia (CLL).
最新的CDK抑制剂

NU6027 : Potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with K_i of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurine-based inhibitors.

研究领域

产品类型

定制您的化合物库

Palbociclib (PD0332991) Isethionate

客户使用Selleck生产的Palbociclib (PD0332991) Isethionate发表文献209篇：

产品安全说明书

CDK抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download Palbociclib (PD0332991) Isethionate SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

临床试验信息 (data from https://clinicaltrials.gov, updated on 2021-05-17)

技术支持

常见问题及建议解决方法

CDK Signaling Pathway Map

CDK Inhibitors with Unique Features

相关CDK产品