Ruxolitinib Phosphate

For research use only. Not for use in humans.

目录号:S5243 别名: INCB018424, INC424 中文名称:鲁索利替尼

Ruxolitinib Phosphate Chemical Structure

CAS No. 1092939-17-7

Ruxolitinib Phosphate (INCB018424, INC424)是Ruxolitinib的磷酸盐形式。Ruxolitinib 是第一个应用于临床的,有效的,选择性JAK1/2抑制剂,在无细胞试验中IC50为3.3 nM/2.8 nM。作用于JAK1,JAK2与作用于JAK3相比,选择性高130多倍。Ruxolitinib 通过毒性线粒体自噬杀死肿瘤细胞。Ruxolitinib 可诱导自噬并增强细胞凋亡。

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RMB 3030.5 现货
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客户使用Selleck生产的Ruxolitinib Phosphate发表文献136篇:

产品安全说明书

JAK抑制剂选择性比较

生物活性

产品描述 Ruxolitinib Phosphate (INCB018424, INC424)是Ruxolitinib的磷酸盐形式。Ruxolitinib 是第一个应用于临床的,有效的,选择性JAK1/2抑制剂,在无细胞试验中IC50为3.3 nM/2.8 nM。作用于JAK1,JAK2与作用于JAK3相比,选择性高130多倍。Ruxolitinib 通过毒性线粒体自噬杀死肿瘤细胞。Ruxolitinib 可诱导自噬并增强细胞凋亡。
靶点
JAK2 [1]
(Cell-free assay)
JAK1 [1]
(Cell-free assay)
2.8 nM 3.3 nM
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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HEL NXLaV4ZNSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MXSzJIRigXN? M13iW2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgTGVNKGOnbHzzJIhiemKxcnnu[{BLSUt{IG[2NVdHKG23dHHueEBu\WG|dYLl[EBi\nSncjCzJIRigXNiYomgR2NMQCCjc4PhfUwhUUN3ME23MlY{Qc7:TR?= NXz6N3lxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C5PFE2PzhpPkOwPVgyPTd6PD;hQi=>
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insect cells Ml7uSpVv[3Srb36gZZN{[Xl? M4r6UFExKG2rboO= NV3HWJh{UW6qaXLpeIlwdiCxZjDy[YNwdWKrbnHueEBpfW2jbjDOMZRmem2rbnHsJGdUXC22YXfn[YQhUkGNMjCoPFMyKHSxIEGxN|IhemW|aXT1[ZMqKGW6cILld5Nm\CCrbjDpcpNm[3RiY3XscJMhfXOrbnegOWZCVS2uYXLlcIVlKEeHRWDMXXdUTlCDS1vLMW5JOiCyZYD0bYRmKGG|IIP1ZpN1emG2ZTDh[pRmeiBzMDDtbY5{KGmwIIDy[ZNmdmOnIH;mJFUhdU1iQWTQJIJ6KGOjbHnw[ZIhdW:kaXzpeJkhe2irZoSgZZN{[XluIFnDOVA:OC5yMt88US=> NX24fphGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{KyPVc4PDNpPkOyNlk4PzR|PD;hQi=>
BAF3 NWXDO4tWS3m2b4TvfIlkcXS7IHHzd4F6 MWK0PEBpenN? MWjDfZRwfG:6aXPpeJkh[WejaX7zeEBud3W|ZTDCRWY{KGOnbHzzJIV5eHKnc4PpcochUkGNMjDWOlE4TiCvdYThcpQh[W[2ZYKgOFghcHK|IHL5JGNmdGyWaYTldmdtdyCjc4PhfUwhUUN3ME2wMlEzPs7:TR?= MmjOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVc5QTl2MT:nQmNpTU2ETEyvZV4>

... Click to View More Cell Line Experimental Data

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

溶解度 (25°C)

体外 DMSO 80 mg/mL (197.84 mM)
Water 29 mg/mL (71.71 mM)
Ethanol 8 mg/mL (19.78 mM)

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 404.36
化学式

C17H18N6.H3O4P

CAS号 1092939-17-7
储存条件 粉状
溶于溶剂
别名 INCB018424, INC424

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02596347 Completed Procedure: Blood draw|Procedure: bronchoscopy Chronic Beryllium Disease (CBD)|Beryllium Sensitization (BeS) National Jewish Health April 2015 --
NCT01787552 Completed Drug: LDE225|Drug: INC424 Primary Myelofibrosis|Thrombocytosis|Essential Thrombocythemia|Polycythemia Vera|Myeloproliferative Disorders|Bone Marrow Diseases|Hematologic Diseases|Blood Coagulation Disorders|Blood Platelet Disorders|Hemorrhagic Disorders Novartis Pharmaceuticals|Novartis May 8 2013 Phase 1|Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项
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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID