3-Methyladenine (3-MA)

For research use only. Not for use in humans.

目录号：S2767 别名： NSC 66389 中文名称：3-甲基腺嘌呤

3-Methyladenine (3-MA) Chemical Structure

CAS No. 5142-23-4

3-Methyladenine (3-MA, NSC 66389) 是一种选择性PI3K抑制剂，作用于Vps34和PI3Kγ，在 HeLa细胞中IC50分别为25 μM和60 μM；永久性抑制I型PI3K，但对III型PI3K的抑制是短暂的，也会阻断自噬体的形成。3-Methyladenine (3-MA)可成功应用于抑制线粒体自噬。现配现用（加热助溶）。

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50mg	RMB 579.66	现货
500mg	RMB 3010.37	现货
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Cell Death Dis, 2016, 7(12):e2527

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Hum Mol Genet, 2016, 25(18):3908-3924

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J Transl Med, 2016, 14:46

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Sci Rep, 2016, 6:22827

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J Biol Chem, 2016, 291(52):26922-26933

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Biomed Pharmacother, 2016, 78:280-290

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Neurochem Int, 2016, 96:100-12

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Int J Oncol, 2016, 48(4):1710-20

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J Agric Food Chem, 2016, 64(8):1702-11

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World J Gastroenterol, 2016, 22(18):4501-14

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Am J Transl Res, 2016, 8(7):3251-65

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Cancer Med, 2016, 5(10):2953-2964

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产品安全说明书

PI3K抑制剂选择性比较

生物活性

产品描述

靶点

Vps34 ^[1] (HeLa cells)	PI3Kγ ^[1] (HeLa cells)
25 μM	60 μM

体外研究

3-MA对Vps34轻微的偏向性可能是由于Vps34中某个特异性的疏水环形结构可以环绕在3-MA的3-甲基基团外面造成的^[1] 。据报道对于正常培养和饥饿处理的癌细胞3-MA都能引起细胞死亡。3-MA还可以不通过抑制自吞噬来抑制细胞迁移和入侵，这表明3-MA 除了抑制自吞噬之外还有其它生物功能。3-MA可以造成半胱天冬酶依赖的细胞死亡，这一功能与它对自吞噬的抑制无关。用5mM 3-MA处理葡萄糖饥饿Hela细胞可降低gfp-lc3阳性细胞比例至23%。3-MA处理细胞12到48小时内 LC3-I 的水平上升而LC3-II 水平下降。LC3-I转为为 LC3-II 的过程被3-MA抑制了。 2.5 mM 或5 mM 3-MA 处理HeLa 细胞一天并不影响细胞存活率, 而 10 mM 3-MA 处理一天会造成细胞存活率下降25.0% 。 2.5, 5 或 10 mM 3-MA 处理细胞两天分别使细胞存活率下降 11.5%, 38.0% 和79.4% 。3-MA 降低细胞存活率的作用具有时间和剂量依赖特性。3-MA 明显缩短nocodazole诱导的前中期阻断时间^[2]。3-MA 通过抑制自吞噬来抑制SU11274诱导的细胞死亡^[3]。在野生型MEF细胞中延长 3-MA处理时间 (最多 9 小时) 明显造成 LC3 I 到 II 转换。延长 3-MA处理时间会明显增加GFP-LC3的聚集而wortmannin不具有此功能。3-MA介导的LC3 转换和游离 GFP 释放是ATG7依赖的。 3-MA处理会导致 p62 蛋白水平明显升高。即使在Atg5−/− 的MEF细胞中3-MA 也会使p62 水平升高，就像在DOX介导的ATG5缺失的细胞中一样。3-MA以不同方式抑制 I 型和 III型 PI3K。与野生型细胞相比，在Tsc2−/−细胞中3-MA诱导的 LC3 I 到 LC3 II 转换过程大幅下降。3-MA会破坏mTOR复合物1的拮抗自吞噬功能^[4]。

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
K562	MV\GeY5kfGmxbjDBd5NigQ>?	MmTXNVBuVQ>?	NH3SbocycA>?		MoD6[IVkemWjc3XzJJRp\SCneIDy[ZN{cW:wIH;mJGxEOy2LSTDhcoQhfGinIH\vdo1ifGmxbjDv[kBifXSxcHjh[49{d22ncx?=	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTh4NECzO{c,OjF6NkSwN\|c9N2F-
Jurkat	Mkm2SpVv[3Srb36gRZN{[Xl?	MVqxNI1O	NVu3epM{OWh?		MmHT[IVkemWjc3XzJJRp\SCneIDy[ZN{cW:wIH;mJGxEOy2LSTDhcoQhfGinIH\vdo1ifGmxbjDv[kBifXSxcHjh[49{d22ncx?=	M2XXRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOE[0NFM4Lz5{MUi2OFA{PzxxYU6=
HeLa	M1z0TWN6fG:2b4jpZ4l1gSCDc4PhfS=>	MYKycW0>	NVnpUXZzOjSq		M{DQN4lvcGmkaYTld{B1cGViY4n0c5RwgGmlaYT5JI9nKHOrbHnibY5qdiC2bzDI[WxiKGOnbHzzMi=>	M{PBeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOEe1N\|g2Lz5{MUi3OVM5PTxxYU6=
PC12/TetOn	MljqSpVv[3Srb36gRZN{[Xl?	NYXVRYNkOC5zL{HtUS=>	MoPxNVhp		Mm\McIVi\HNidH:g{tEue3mwKGfULUBi[2O3bYXsZZRqd25uIITvfIlkcXS7LDDhcoQhd2yrZ3;t[ZIh\m:{bXH0bY9vyqB?	M4DvPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOUC2OlU6Lz5{MUmwOlY2QTxxYU6=
RMPI8226	M4KzZWZ2dmO2aX;uJGF{e2G7	NEHyVFc2dU1?	NVXaeIRUOWh?		NFSwW5l{fXCycnXzd4V{KHSqZTDs[ZZmdCCxZjDheZRweGijZ4mgeY5l\XJiboX0dolmdnRiZHXwcIV1cW:w	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTlzNU[yNEc,OjF7MUW2NlA9N2F-
MCF-7	NYDKd5M4TnWwY4Tpc44hSXO\|YYm=	M1:5TFExdU1?	NYLJ[4dJPDiq		NHzH[lZjdG:la4OgZZV1d3CqYXf5JIlv\HWlZXSgZpkh[m:{dHX6c41q[g>?	NY\JcVdsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5N\|E6OzdpPkKxPVMyQTN5PD;hQi=>
HBx	NEfJT25CeG:ydH;zbZMhSXO\|YYm=	MmPpNVBuVQ>?	MWm0PIg>	MWTEUXNQ	NVPlPVlscW6lcnXhd4V{KGOnbHyg[IVifGh?	Mm\tQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyMkCwO\|goRjJ{MEKwNFc5RC:jPh?=
Marc-145	MXPGeY5kfGmxbjDBd5NigQ>?	MofHOY1O	MmHENVIwOjRxM{\o		Mki3doVlfWOnczD0bIUhWFKUU2[geIl1\XK\|IHHu[EB1cGVicILveIVqdiCneIDy[ZN{cW:w	NFf2Zog9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkGxPVkxOCd-MkKxNVk6ODB:L3G+
U937	NXq2N2ZJTnWwY4Tpc44hSXO\|YYm=	MnHBNo1O	NX;3V4JxOTKq		MlKy[IVkemWjc3XzJJRp\SCjdYTvdIhi\3licnH0bY/DqA>?	MnOyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzNUWxOVAoRjJ{MUW1NVUxRC:jPh?=
BGC-823	MWTGeY5kfGmxbjDBd5NigQ>?	NUHtOYNHPW2P	NUjQfnlbOmh?		NHrtOI1qdmirYnn0d{B1cGVicnH0[UBw\iCjdYTvdIhi\2mlIHPlcIx{	NWDUUFdSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzNlIyPTJpPkKyN\|IzOTV{PD;hQi=>
A549	MXvGeY5kfGmxbjDBd5NigQ>?	MYGwMlFuVQ>?	M{\hN\|I1cA>?		NHn2Wmx{fXCycnXzd4V{KFOXMUGyO\|QucW6mdXPl[EBk\WyuIHTlZZRp	NYr0R3dGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0OlY6PjBpPkKyOFY3QTZyPD;hQi=>
pDCs	MXzGeY5kfGmxbjDBd5NigQ>?	M333UlExdU1?	NXO1TXFtOC53aB?=		M3XKTOKhemWmdXPld{B1cGViaX7keYN1cW:wIH;mJGlHVi4QsTDifUB{e1KQQUSw	Ml:yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ\|OU[1PVkoRjJ{M{m2OVk6RC:jPh?=
HeLa	Mon2RZBweHSxc3nzJGF{e2G7	M2rWZlVuVQ>?	NEHSVZMzPGh?		NHH0fGVqdmS3Y3XzJINie3Cjc3Wt[IVx\W6mZX70JINmdGxiZHXheIg>	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV2NUGyPEc,OjJ3NEWxNlg9N2F-
U251	M4rse2Fxd3C2b4Ppd{BCe3OjeR?=	MUG1cW0>	NYP1dpNGOjSq		NH;lVmVqdmO{ZXHz[ZMhWzFvaX7keYNm\CClZXzsJIRm[XSq	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV5OUe4PEc,OjJ3N{m3PFg9N2F-
MCF-7	M1LpemFxd3C2b4Ppd{BCe3OjeR?=	MXiwMlFuVQ>?	MoKyOog>		MmfZ[Y5p[W6lZYOgd4lzfGmwb3ytbY5lfWOnZDDhdI9xfG:\|aYO=	NWCxXopnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK3OVE6QDlpPkKyO\|UyQTh7PD;hQi=>
PC-3	MWLBdI9xfG:\|aYOgRZN{[Xl?	NInSW3AzdU1?	NUnIWItnOmh?		MmDBbY5kemWjc3XzJG9TUS2rbnT1Z4VlKGOnbHyg[IVifGh?	M2[wZ\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{N{S1OVgxLz5{Mke0OVU5ODxxYU6=
HCT116	M32yU2Fxd3C2b4Ppd{BCe3OjeR?=	MWG1cW0>	M4LpWVI1cA>?	NWPW[JVxTE2VTx?=	M4DlToVvcGGwY3XzJIFxcWenbnnuMYlv\HWlZXSgZ4VtdCCmZXH0bC=>	NIHUTHo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[yOlUzOid-MkS2NlY2OjJ:L3G+
U2OS	M1PidWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Ml;oNVBuVQ>?	NE\qUJUzPGh?		MYPpcpRmdnOrZnnld{B1cGViZ4Lve5RpKGmwaHnibZRqd25iaX7keYNm\CCkeTDEc5g>	MmnwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4M{mwNVMoRjJ2NkO5NFE{RC:jPh?=
A2780cp	NH;ISHhCeG:ydH;zbZMhSXO\|YYm=	M3fL[FIvPW2P	NE\jS4cycA>?	M33HXoRlUDKR	NV3SZ4d[\W6qYX7j[ZMh[2m\|cHzheIlvNWmwZIXj[YQh[2WubDDk[YF1cA>?	MmfaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6MUe5OFYoRjJ2OEG3PVQ3RC:jPh?=
HepG2	MULGeY5kfGmxbjDBd5NigQ>?	MXS1cW0>	MmrwOIg>		Mm\xbY5kemWjc3XzJINmdGy3bHHyJIxmfmWuczDv[kBJVMLi	NGjndFA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEexN\|U5Pyd-MkS3NVM2QDd:L3G+
Microglia	M3XpbmFxd3C2b4Ppd{BCe3OjeR?=	NGLWbWg2dU1?	MofVNlRp		NHPoWGpl\WO{ZXHz[ZMhcHmyb4jpZU1qdmS3Y3XkJINmdGxiZHXheIg>	NHLLV\|M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEixPFYxOSd-MkS4NVg3ODF:L3G+
MDA-MB 231	MkP6RZBweHSxc3nzJGF{e2G7	NV\aN\|E2PW2P	MoS2NE42cA>?		Ml;EcY9lfWyjdHXzJHRw[2:vaX9CsuKhcW6mdXPl[EBieG:ydH;zbZM>	Mn3vQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6M{C3PFEoRjJ2OEOwO\|gyRC:jPh?=
PANC-1	NEXrdnNCeG:ydH;zbZMhSXO\|YYm=	NVH5RWFrOW2P	M2TJZVQ5cA>?	MX3EUXNQ	NHXjdJNmdmijbnPld{Bjd3K2ZYrvcYljNWmwZIXj[YQh[2WubDD2bYFjcWyrdImgcI9{ew>?	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDh2MkG1PEc,OjR6NEKxOVg9N2F-
MDA-MB-231	NVfwSINbTnWwY4Tpc44hSXO\|YYm=	M4TIO\|JuVQ>?	MlTxOFhp		M4joSJBzd22xdHXzJHRONWmwZIXj[YQh[2WubDDk[YF1cA>?	M3zrbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUewOlc3Lz5{NEm3NFY4PjxxYU6=
MDA-MB-231	NULNeFViTnWwY4Tpc44hSXO\|YYm=	MXiycW0>	MXKyOIg>		NVLNb3U6cW6qaXLpeJMh[XW2b4DoZYd6KGmwZIXj[YQh[nliVF5CpC=>	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl5ME[3Okc,OjR7N{C2O\|Y9N2F-
MCF-7	M2\WUGZ2dmO2aX;uJGF{e2G7	MlTBNo1O	NXnrO4t3PDiq		NUf1bWZReHKxbX;0[ZMhXE1vaX7keYNm\CClZXzsJIRm[XSq	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl5ME[3Okc,OjR7N{C2O\|Y9N2F-
MCF-7	NXnhPZFpTnWwY4Tpc44hSXO\|YYm=	NWToUZZyOm2P	M2jMWFI1cA>?		MXnpcohq[mm2czDheZRweGijZ4mgbY5lfWOnZDDifUBVVcLi	M17TNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUewOlc3Lz5{NEm3NFY4PjxxYU6=
HepG2	NWTzOHBVSXCxcITvd4l{KEG\|c3H5	NGDnd4k{dU1?	MljMOYg>		MWLy[YR2[2W\|IHPlcIwh[XCxcITvd4l{KGmwZIXj[YQh[nliUVTz	NETzdIw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkizOlU6PSd-MkK4N\|Y2QTV:L3G+
HeLa	M4DSVWFxd3C2b4Ppd{BCe3OjeR?=	NH7SfmwyOG2P	NVrEN29[Omh?		NETqfZNl\WO{ZXHz[ZMh[2WubDD2bYFjcWyrdImgZ48ufHKnYYTt[Y51KHerdHigVGVK	NGH6Om49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{CwNFE{PSd-MkOwNFAyOzV:L3G+
SK-HEP-1	NXTVWmR5SXCxcITvd4l{KEG\|c3H5	MVSxNI1O	M2DFc\|Fp		MmTwdJJwfGWldIOgZYdicW6\|dDDheZRweGijZ4mgZY5lKGmwZIXj[ZMh[XCxcITvd4l{KGmwIHL1[oFtcW5vdILlZZRm\CClZXzsdy=>	M1[4XlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OEW4OlQ6Lz5{Mki1PFY1QTxxYU6=
MDA-MB231	NYn6TlRJTnWwY4Tpc44hSXO\|YYm=	NVLsfYR2PW2P	NIi0fpkycA>?		Ml7QbY5kemWjc3XzJJJme3[ncnH0do9tNW2nZHnheIVlKGOjc4Dhd4Uh[WO2aY\heIlwdiCjbnSgZ4VtdCCmZXH0bC=>	MoHVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyOEi4OVAoRjJ\|MEi4PFUxRC:jPh?=
PaCa44	MmfhRZBweHSxc3nzJGF{e2G7	NHTaOVEzNjWvTR?=	MlzXNYg>		MXPy[YR2[2W\|wrDn[Y5qeGmwLX3l[IlifGWmIHHwc5B1d3Orcx?=	M1fGVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MUK0NVEzLz5{M{GyOFEyOjxxYU6=
T-47D	NWG0U3B7TnWwY4Tpc44hSXO\|YYm=	MWmxNI1O	MY[ybC=>		NVPKR5RvcW6qaXLpeJMh[XW2b4DoZYd6KHC{b3Pld5Mh[W6mIHnuZ5Jm[XOnczDyZZBidXmlaX6gbY5lfWOnZDDhdI9xfG:\|aYO=	MmHIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN\|MECwNlYoRjJ\|M{CwNFI3RC:jPh?=
GTL-16	M1naRmFxd3C2b4Ppd{BCe3OjeR?=	NVfiblN6PW2P	NYjKbVNTOjSq		NH;I[Ixz\WS3Y3XzJINmdGxidnnhZoltcXS7IHHzJINwdXCjcnXkJJRwKGOnbHzzJJRz\WG2ZXSge4l1cCCPRWSgbY5pcWKrdH;ydy=>	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{S5NEc,OjN\|MUO0PVA9N2F-
U251MG	MXXGeY5kfGmxbjDBd5NigQ>?	MV[zcW0>	MWCxbC=>		NGPrWId{fXCycnXzd4V{KEyFMz3JTUBxem:2ZXnuJIV5eHKnc4Ppc44>	M2rQV\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|M{O4OlE5Lz5{M{OzPFYyQDxxYU6=
T24	M{jHcGZ2dmO2aX;uJGF{e2G7	NYGyR2hTOTCvTR?=	M4jsWFFp		NHrTbo1z\WS3Y3XzJJRp\SClbHXheoFo\SCxZjDMR\|Mh[W[2ZYKgZoFq[2GuaX6geJJm[XSvZX70	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzN3NEC4NEc,OjN\|NUSwPFA9N2F-
HUVECs	MXPGeY5kfGmxbjDBd5NigQ>?	M1LaZlNuVQ>?	MWeyOIg>		NUG2Z2FZ[myxY3vzJJRp\SCycn;0[YN1cX[nIHXm[oVkfCCxZjDy[ZN3\XKjdILvcEBjgSCrbnjpZol1cW6pIHH1eI9xcGGpeR?=	NIHsNm09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{O1PFkzQCd-MkOzOVg6Ojh:L3G+
MCF-7	MW\GeY5kfGmxbjDBd5NigQ>?	MYK1cW0>	MWCyOIg>		NXraXGpWcW6qaXLpeJMhe3Sjco\heIlwdi2rbnT1Z4VlKGG3dH;wbIFogQ>?	NFv0SW89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{O5OVY4QSd-MkOzPVU3Pzl:L3G+
Hela	NWD4TZVwTnWwY4Tpc44hSXO\|YYm=	MoL6OY1O	NYDpcGJpOjSq		NWXTZmJUcW6qaXLpeJMhe3Sjco\heIlwdi2rbnT1Z4VlKGG3dH;wbIFogQ>?	NGLub\|I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{O5OVY4QSd-MkOzPVU3Pzl:L3G+
OR6	MXvGeY5kfGmxbjDBd5NigQ>?	NVTNOItlOTCvTR?=	M{HjVlczcA>?		MXrzeZBxemW\|c3XzJGhEXiC{ZYDsbYNifGmxbjDhcoQh\m:{bXH0bY9vKG:oIHH1eI9xcGGpb4PvcYV{	NYT6WIQyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzPVU5PzVpPkKzN\|k2QDd3PD;hQi=>
HT-29	NInPc4VHfW6ldHnvckBCe3OjeR?=	NFjCcHAydU1?	M1;UNFQ5Nzl4aB?=		MWrpcohq[mm2czDBUXBMKGmwZIXj[ZMh[XW2b4DoZYdq[yClZXzsJIRm[XSq	NF7ib4s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{WwPFI4Oid-MkO1NFgzPzJ:L3G+
SH-SY5Y	M3n3T2N6fG:2b4jpZ4l1gSCDc4PhfS=>	M3PXZVVuVQ>?	NIHTZZczPGh?		NWq2S5RxcW6lcnXhd4V{KFCFTjD0c5hq[2m2eR?=	NH;Z[Zo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{WyOVI3PSd-MkO1NlUzPjV:L3G+
Saos-2	MYDBdI9xfG:\|aYOgRZN{[Xl?	M3e0blFuVQ>?	MYC5Oog>		M4nsdYlv[3KnYYPld{Bk\WyuIHTlZZRpKGmwZIXj[YQh[nliUFPY	MlvrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3NkOxO\|EoRjJ\|NU[zNVcyRC:jPh?=
1321N1	MnXnR5l1d3SxeHnjbZR6KEG\|c3H5	NHLseXQ2dU1?	M{jh[VI1cA>?		MoT5dJJwfGWldIOgZ4VtdCCjZ3HpcpN1KFCFTj3pcoR2[2WmIITvfIlkcXS7	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzV{NUK2OUc,OjN3MkWyOlU9N2F-
A2780	MWXBdI9xfG:\|aYOgRZN{[Xl?	MYq1cW0>	NUfaendiOjSq		MnXYZ49vfmW{dIOgSnR[PzJyIIfpeIghS0SGUDDpcpRwKGGwIHHk[Il1cX[nIHXm[oVkfCC2b4fhdoR{KGurbHzpcochd3[jcnnhckBk[W6lZYKgZ4VtdHN?	MnnHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3OUKyPFEoRjJ\|NUmyNlgyRC:jPh?=
OV2008	NYP0NFhCSXCxcITvd4l{KEG\|c3H5	MnrLOY1O	MkDNNlRp		M3;UWoNwdn[ncoTzJGZVYTd{MDD3bZRpKEOGRGCgbY51dyCjbjDh[IRqfGm4ZTDl[oZm[3RidH;3ZZJleyCtaXzsbY5oKG:4YYLpZY4h[2GwY3XyJINmdGy\|	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzV7MkK4NUc,OjN3OUKyPFE9N2F-
PC12	MkPNSpVv[3Srb36gRZN{[Xl?	NUizeGJFOTCvTR?=	MUeyOIg>	NGXpUIl4[XSnch?=	MWRCpIlvcGmkaYTzJINpgW2xdIL5dJNqdi2uaXvlJJBzd3SnYYPvcYFtKGGldHn2bZR6Ng>?	M1nVbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NkCzPVc6Lz5{M{[wN\|k4QTxxYU6=
SH-SY5Y	M176VGFxd3C2b4Ppd{BCe3OjeR?=	MomzOY1O	MUGxbC=>		NHy4WYFi[m:uaYPo[ZMh[2WuYYP0do9tKG6ndYLvdJJwfGWldHn2[UBm\m[nY4S=	NXXlTJV6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NVk{QTVpPkKzOlE6Ozl3PD;hQi=>
SH-SY5Y	MUnGeY5kfGmxbjDBd5NigQ>?	MoXzNY1O	NEPRNGczPGh?		NG\ZN4RqdmirYnn0d{B1cGViYYX0c5Bp[We7IHnu[JVk\WRiYomgWG9EWA>?	MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd2M{G0PEc,OjN5NEOxOFg9N2F-
HepG2	NHrYZ5dHfW6ldHnvckBCe3OjeR?=	M2\MflExdU1?	NF:xR\|czPGh?		MnL1bY5pcWKrdIOgd4lVUUeDUj2gZY5lKEiEU2OtbY5lfWOnZDDheZRweGijZ4m=	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzhzN{C0NEc,OjN6MUewOFA9N2F-
HeLa	NH\YNFBHfW6ldHnvckBCe3OjeR?=	M{jWdlExdU1?	MXSybC=>		NEXXPJN{fXCycnXzd4V{KEyFMzDJTUBmgHC{ZYPzbZNwdg>?	NV33XIhMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4OlQ4OzhpPkKzPFY1PzN6PD;hQi=>
HONE-1	MmTBSpVv[3Srb36gRZN{[Xl?	MlLwOY1O	MWixbC=>		NVi4cplRemWycnXzd4V{KD[{LX3l[IlifGWmIGLPV{Bxem:mdXP0bY9v	NGPSTXE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{i5NlM2QCd-MkO4PVI{PTh:L3G+
MCF7	Ml3MSpVv[3Srb36gRZN{[Xl?	M2C4TFVuVQ>?	M2DKc\|I1cA>?		NXjQfI17cW6lcnXhd4V{KEO3TzDpcoR2[2WmIHPlcIwh\GWjdHi=	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4Mk[yPUc,OjN7NkK2Nlk9N2F-
HO8910	MWPBdI9xfG:\|aYOgRZN{[Xl?	MmfsNVBuVQ>?	NUe2bVEzOTKq		MoTh[Y5p[W6lZYOgRlE6NWmwZIXj[YQh[XCxcITvd4k>	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl6M{[xNEc,OjN7OEO2NVA9N2F-
SMMC-7721	MXfBdI9xfG:\|aYOgRZN{[Xl?	M1XJTlVuVQ>?	MU[yOIg>		MVXheJRmdnWjdHXzJHRPTi4QsTDwdo91\WO2aX;uJIFo[Wmwc4Sgd4VzfW1ic4ThdpZifGmxbj3t[YRq[XSnZDDhdI9xfG:\|aYO=	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB4Nk[5N{c,OjRyNk[2PVM9N2F-
Hep3B	MXHBdI9xfG:\|aYOgRZN{[Xl?	NX7JbJZjPW2P	NY\RToRWOjSq		M{PVNYF1fGWwdXH0[ZMhXE6ILd8xJJBzd3SnY4Tpc44h[WejaX7zeEB{\XK3bTDzeIFzfmG2aX;uMY1m\GmjdHXkJIFxd3C2b4Ppdy=>	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB4Nk[5N{c,OjRyNk[2PVM9N2F-
H460	MWPGeY5kfGmxbjDBd5NigQ>?	NX6zXZMzOTCvTR?=	Mke4OIg>		M{jmcIlv[3KnYYPld{BkcXOybHH0bY4ucW6mdXPl[EBk\WyuIHTlZZRp	MkToQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzN{OyNFgoRjJ2MUezNlA5RC:jPh?=
A549	NULuOFBvTnWwY4Tpc44hSXO\|YYm=	NVLTb4pVOTCvTR?=	MlrSOIg>		MYnpcohq[mm2czDheZRweGijZ4mgbY5lfWOnZDDifUBqenKjZHnheIlwdg>?	NHm3V4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEG0Nlc{PSd-MkSxOFI4OzV:L3G+
H1299	MnvwSpVv[3Srb36gRZN{[Xl?	NGfGfXEyOG2P	MYO0bC=>		M3vL[Ylv[3KnYYPld{BkcXOybHH0bY4ucW6mdXPl[EBk\WyuIHTlZZRp	M{ftbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUezNlA5Lz5{NEG3N\|IxQDxxYU6=
WiDr	NYnweXdTTnWwY4Tpc44hSXO\|YYm=	M3vxXlExdU1?	NHuyNncycA>?		MmnJbY5pcWKrdIOgVGNDVC2rbnT1Z4VlKEyFMzDJTUBmgHC{ZYPzbY9v	MmLaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzOUC0PFkoRjJ2MUmwOFg6RC:jPh?=
LoVo	M4TJZ2Fxd3C2b4Ppd{BCe3OjeR?=	NInWSWo2dU1?	MYm0PIg>		MnTG[Y5p[W6lZYOgSGNCNWmwZIXj[YQh[XCxcITvd4l{Ng>?	NFn2SZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEKwNVgyOid-MkSyNFE5OTJ:L3G+
HepG2 E47	MmXZSpVv[3Srb36gRZN{[Xl?	MmezNk42dU1?	MWi0PIg>		MWnpcoNz\WG\|ZYOgeIhmKHSxeHnjbZR6KG:oIFHBMEBDW09uIHHu[EBES2x2	NX\BclU3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyO\|M4OzhpPkK0Nlc{PzN6PD;hQi=>
RKO	MYPGeY5kfGmxbjDBd5NigQ>?	M{Hne\|JuVQ>?	Mk\SNYg>	M4O1dWROW09?	NVfaWYY3\W6qYX7j[ZMh[2WubDDk[YF1cCCkeTDn[Yxl[W6jbYnjbY4>	MkTEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{OUG3O\|coRjJ2MkmxO\|c4RC:jPh?=
Hep3B	M1rtbWFxd3C2b4Ppd{BCe3OjeR?=	Mn[wNo1O	NIjlR2kyOmh?	Mm\ySG1UVw>?	NWrlXmlQcW6qaXLpeJMhSVqGOEC1OU1qdmS3Y3XkJINmdGxiZHXheIg>	M1TwWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2Mkm3N\|AxLz5{NEK5O\|MxODxxYU6=
ACHN-5968	MoLHRZBweHSxc3nzJGF{e2G7	Mkn3OY1O	NVXFSXN5O2h?		Ml7k[Y5p[W6lZYOgdIFkdGm2YYjlcE1u\WSrYYTl[EBieG:ydH;zbZPDqA>?	MoPkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR\|MEW2NFQoRjJ2M{C1OlA1RC:jPh?=
Huh7	NFH4d5hCeG:ydH;zbZMhSXO\|YYm=	M3:2V\|JuVQ>?	MVOxNog>	NEnTOHFFVVOR	MmjpbY5pcWKrdIOgRXpFQDB3NT3pcoR2[2WmIHPlcIwh\GWjdHi=	M2n1d\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2Mkm3N\|AxLz5{NEK5O\|MxODxxYU6=
UOK257	MUnBdI9xfG:\|aYOgRZN{[Xl?	MXO1cW0>	MUWzbC=>		NVm3c4k5\W6qYX7j[ZMheGGlbHn0ZZhmdC2vZXTpZZRm\CCjcH;weI9{cXQEoB?=	MnTPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR\|MEW2NFQoRjJ2M{C1OlA1RC:jPh?=
ECSCs	MnS5RZBweHSxc3nzJGF{e2G7	M4\3[VExdU1?	NFPqTpo1cA>?		NEPJc4xl\WO{ZXHz[ZMhemGyYX35Z4lvNXS{ZXH0[YQh[XCxcITvd4l{	NIjh[XM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEOxPVExQSd-MkSzNVkyODl:L3G+
MCF-7	NGn3Z2RHfW6ldHnvckBCe3OjeR?=	NWmyTm86OTCvTR?=	NXrWRZB5OjSq		MnLCbY5pcWKrdIOgeIhmKGG3dH;wbIFogSCrbnT1Z4VlKGK7IHPo[Y1wfGincnHwfUBlenWpcx?=	NYK3SWZVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzNVU2PzhpPkK0N\|E2PTd6PD;hQi=>
SGC-7901	M1roSWFxd3C2b4Ppd{BCe3OjeR?=	MWWycW0>	NHHhZmwycA>?		M3;BSIlv[3KnYYPld{BESS12IHnu[JVk\WRiYYDvdJRwe2m\|	M4jmflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{KxN\|QxLz5{NEOyNVM1ODxxYU6=
SMMC-7721	Mn3nRZBweHSxc3nzJGF{e2G7	MorCNo1O	NFrYbXgycA>?		NHXPbmZqdmO{ZXHz[ZMhS0FvNDDpcoR2[2WmIHHwc5B1d3Orcx?=	M2PFcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{KxN\|QxLz5{NEOyNVM1ODxxYU6=
T24	MojWRZBweHSxc3nzJGF{e2G7	M3\3c\|VuVQ>?	NIGxdlkyNjWq		NFvnS4pxd3SnboTpZZRmeyClZXzlZ495cWJvaX7keYNm\CCjcH;weI9{cXN?	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN2OUG3Okc,OjR\|NEmxO\|Y9N2F-
NTUB1	M1nGZWFxd3C2b4Ppd{BCe3OjeR?=	NITxPJM2dU1?	MV6xMlVp		MmqxdI91\W62aXH0[ZMh[2WuZXPvfIljNWmwZIXj[YQh[XCxcITvd4l{	MkHUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR\|NEmxO\|YoRjJ2M{S5NVc3RC:jPh?=
MG-63	M2j5V2Fxd3C2b4Ppd{BCe3OjeR?=	M4\VclExdU1?	NVT0ZotxOTKq		NVj3dIlX\W6qYX7j[ZMhTFBvaX7keYNm\CCjcH;weI9{cXN?	MojUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR\|NUizNFEoRjJ2M{W4N\|AyRC:jPh?=
MG-63	MknCRZBweHSxc3nzJGF{e2G7	MUewMlUwOW2P	NGXkT2E{Omh?		NGTxN2RmdmijbnPld{B{[Wyrbn;tfYNqdi2rbnT1Z4VlKGOnbHygZZBweHSxc3nz	MkC5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR\|NUizOFIoRjJ2M{W4N\|QzRC:jPh?=
MG-63	NXj4XJpJTnWwY4Tpc44hSXO\|YYm=	M4\IS\|AvPS9zbV2=	M1[1Z\|Q5cA>?		MVrpcoR2[2W\|IIPhcIlvd227Y3nuMYlv\HWlZXSgZ4VtdCC4aXHibYxqfHlibH;zdy=>	Mli4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR\|NUizOFIoRjJ2M{W4N\|QzRC:jPh?=
U2OS	M{jHcWZ2dmO2aX;uJGF{e2G7	MX2wMlUwOW2P	MnGxOFhp		MYfpcoR2[2W\|IIPhcIlvd227Y3nuMYlv\HWlZXSgZ4VtdCC4aXHibYxqfHlibH;zdy=>	MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN3OEO0Nkc,OjR\|NUizOFI9N2F-
HGC-27	M3fGRmZ2dmO2aX;uJGF{e2G7	MXGxNI1O	NYLvbVdLOWh?		NXT5[2Z{cW6qaXLpeJMhfGinIHPlcIwhfmmjYnnsbZR6KGyxc4OgZpkhWkGGMECxJI9zKE2NLUKyNFY>	NIL5Z\|c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NESxOlM1QSd-MkS0NVY{PDl:L3G+
HCT116	NIfTWpZCeG:ydH;zbZMhSXO\|YYm=	NWLPdm01PW2P	M{\hdVI1cA>?		Mn\K[Y5p[W6lZYOgeIhmKGGyb4D0c5NqeyCrbnT1Z4VlKGK7IHHwbYdmdmmw	MnS2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4Mk[1NlIoRjJ2NkK2OVIzRC:jPh?=
A549	MlHKRZBweHSxc3nzJGF{e2G7	NYP3eHdjOTCvTR?=	MnLFOFhp		MkXxZYNk\WyncnH0[ZMhfGinIILl[JVkfGmxbjDv[kBk\WyuII\pZYJqdGm2eTDpcoR2[2WmIHL5JHBVYA>?	NEXWS3g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[yOlczOid-MkS2NlY4OjJ:L3G+
Saos-2	NF;Td\|lCeG:ydH;zbZMhSXO\|YYm=	NEixbFIyOG2P	MnnTNlRp		NX7nZphKcW62ZX7zbYZq\XNidHjlJIdzd3e2aDDpcohq[mm2aX;uJI9nKHSqZTDVNm9UKGOnbHzzJIlv\HWlZXSgZpkhTG:6	M4f5WVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkO5NFE{Lz5{NE[zPVAyOzxxYU6=
U2OS	NWfWUYJ7SXCxcITvd4l{KEG\|c3H5	Moq0NVBuVQ>?	M2\keVI1cA>?		NWfOUIFscW62ZX7zbYZq\XNidHjlJIdzd3e2aDDpcohq[mm2aX;uJI9nKHSqZTDVNm9UKGOnbHzzJIlv\HWlZXSgZpkhTG:6	NF;NU4w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[zPVAyOyd-MkS2N\|kxOTN:L3G+
HepG2	MkK2SpVv[3Srb36gRZN{[Xl?	M4L5[\|VuVQ>?	NYfIT5ZqPGh?		NYr5cHJIcW6lcnXhd4V{KEiOIILlcIVie2V?	NYrJPXlJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3NVM2QDdpPkK0O\|E{PTh5PD;hQi=>
A549	M4fG[mFxd3C2b4Ppd{BCe3OjeR?=	MmHrOY1O	NYjZUpVpPDiq		NHzyNm5l\WO{ZXHz[ZMhfGinIIDldoNmdnSjZ3Wgc4Yh[2WubDDk[YF1cCCjbnSg[ZhxemW\|c3nvckBt\X[nbIOgc4Yh[2G\|cHHz[U0{NCCEZXPsbY4uOSCjbnSgUGM{NUmL	MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDdyNkOwN{c,OjR5ME[zNFM9N2F-
A2780cp	Ml7tRZBweHSxc3nzJGF{e2G7	MoXQNk42dU1?	NVnLfo5MOWh?	M1PxUIRlUDKR	MnjS[Y5p[W6lZYOgZ4l{eGyjdHnuMYlv\HWlZXSgZ4VtdCCmZXH0bC=>	M3LONVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEG3PVQ3Lz5{NEixO\|k1PjxxYU6=
Microglia	MWLBdI9xfG:\|aYOgRZN{[Xl?	NEfYWG82dU1?	NUTsTpc{OjSq		MkLs[IVkemWjc3XzJIh6eG:6aXGtbY5lfWOnZDDj[YxtKGSnYYTo	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDhzOE[wNUc,OjR6MUi2NFE9N2F-
HT-29	MoLORZBweHSxc3nzJGF{e2G7	NGnZ[3EydU1?	NWnNboNoPDiq	NWnsS4dXTE2VTx?=	NUS2c5RF\W6qYX7j[ZMh[m:{dHX6c41q[i2rbnT1Z4VlKGOnbHygeoli[mmuaYT5JIxwe3N?	MmXVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6NEKxOVgoRjJ2OESyNVU5RC:jPh?=
MDR	NH3IXphCeG:ydH;zbZMhSXO\|YYm=	MW[xNI1O	NXS4ZphxPmh?		MmHWd5Rz\W6pdHjlcpMhfGinIIDve4VzKG:oIHHueIlk[W6lZYKg[JJ2\3N?	M{\wXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MEG5O\|AyLz5{NUCxPVcxOTxxYU6=
H157	MkT4SpVv[3Srb36gRZN{[Xl?	MXq1cW0>	MknNNog>		NGXuSW1{fXCycnXzd4V{KFOSQzDpcoR2[2WmIHHjZ5VufWyjdHnvckBw\iCOQ{OtTWk>	MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTJ6NU[yPEc,OjV{OEW2Nlg9N2F-
A549	NFzSTIhHfW6ldHnvckBCe3OjeR?=	MnrqOY1O	MYCybC=>		Ml\Xd5VxeHKnc4Pld{BUWENiaX7keYNm\CCjY3P1cZVt[XSrb36gc4YhVEN\|LVnJ	NInCN\|k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUK4OVYzQCd-MkWyPFU3Ojh:L3G+
A2780cp	MkDlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkPyNY1O	NX3OOIp1OWh?		MlrlbY5kemWjc3XzJINqe3CuYYTpck1qdmS3Y3XkJINmdGxiZHXheIg>	NYTjNYZ7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWzNlI3QTRpPkK1N\|IzPjl2PD;hQi=>
NBL-W-S	NVLrR4lxSXCxcITvd4l{KEG\|c3H5	MXyxcW0>	M{DjdlZp		NI\HO2dqdmO{ZXHz[ZMh[2WubDDhdI9xfG:\|aYOgbY5lfWOnZDDifUBISU6WLU[x	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTN{M{KyNkc,OjV\|MkOyNlI9N2F-
NBL-W-S	MojlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXfufYZJOW2P	MnTlOog>		M3HrT4VvcGGwY3XzJGdCVlRvNkGgeI95cWOrdIm=	M4LiZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3M{KzNlIzLz5{NUOyN\|IzOjxxYU6=
A549	MXTBdI9xfG:\|aYOgRZN{[Xl?	NEXkb2Y2dU1?	MofUNog>	NYK0SIF[TE2VTx?=	NH\GenVqdmirYnn0d{BDTE2FLXnu[JVk\WRiYYDvdJRwfGmlIHPlcIwh\GWjdHi=	M1XoWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{G2OVYyLz5{NUexOlU3OTxxYU6=
95D	NUPPcHhSSXCxcITvd4l{KEG\|c3H5	NXXKNZJHPW2P	M1XJZVJp	MVrEUXNQ	M{\QVYlvcGmkaYTzJGJFVUNvaX7keYNm\CCjcH;weI91cWNiY3XscEBl\WG2aB?=	MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTdzNkW2NUc,OjV5MU[1OlE9N2F-
A549	NHr2elRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3zLXlNuVQ>?	NF:0WJczcA>?	MULEUXNQ	MVry[YR2[2W\|IHfyc5d1cCCrbnjpZol1d3K7IHXm[oVkfCCxZjDCSG1E	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTdzNkW2NUc,OjV5MU[1OlE9N2F-
95D	NV7WTHlRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4\yZlNuVQ>?	MnzYNog>	NH70WZFFVVOR	MYfy[YR2[2W\|IHfyc5d1cCCrbnjpZol1d3K7IHXm[oVkfCCxZjDCSG1E	NXrkbplCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3NVY2PjFpPkK1O\|E3PTZzPD;hQi=>
Nara-H	MoPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NULQXnQ{PW2P	MkPUOFhp		NWHCR5FQ\W6qYX7j[ZMhfGWvc3nyc4xqdXW\|bXXkbYF1\WRic4XwdJJme3Orb36gc4YhVmG{YT3IJINmdGxicILvcIln\XKjdHnvci=>	Ml7XQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6MEWwN\|MoRjJzOEC1NFM{RC:jPh?=
HUVECs	M1XZU2Z2dmO2aX;uJGF{e2G7	NWPTV4xFOTCvTR?=	MnTvNE42cA>?		MXTk[YNz\WG\|ZYOgeIhmKEGJRT3CV2FqdmS3Y3XkJIF2fG:yaHHnfUBt\X[n	Mkf5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2Nki1PVIoRjJzNE[4OVkzRC:jPh?=
HepG2	NE\vUXlCeG:ydH;zbZMhSXO\|YYm=	NHf3eJUzdU1?	NVnX[WR1OWh?		Mnj0[Y5p[W6lZYOgdoFlcWG2aX;uMYlv\HWlZXSgZ4VtdCCmZXH0bC=>	MnXVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2NUO2PVEoRjJzNEWzOlkyRC:jPh?=
U-2 OS	MYLxTHRUKGG\|c3H5				MkD0dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKFVvMjDPV{Bk\Wyucx?=	Mkf3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
A673	M4f3TJFJXFNiYYPzZZk>				M4\3XZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCDNkezJINmdGy\|	NGPMPGU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
DAOY	MWPxTHRUKGG\|c3H5				M2XtVZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCGQV;ZJINmdGy\|	NWq1[GM{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
Saos-2	M2LnVZFJXFNiYYPzZZk>				NXLNe4d4eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IGPhc5MuOiClZXzsdy=>	NX;BeYRNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
BT-37	MUXxTHRUKGG\|c3H5				Mn;IdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKEKWLUO3JINmdGy\|	Mn\aQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
RD	MoPRdWhVWyCjc4PhfS=>				MlK0dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKFKGIHPlcIx{	M3XYSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SK-N-SH	MmjNdWhVWyCjc4PhfS=>				MnXqdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKFONLV6tV2gh[2WubIO=	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
BT-12	MWjxTHRUKGG\|c3H5				Mnu2dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKEKWLUGyJINmdGy\|	MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
MG 63 (6-TG R)	NWHEbmdHeUiWUzDhd5NigQ>?				MWXxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhVUdiNkOgLFYuXEdiUjmgZ4VtdHN?	NEKwZYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
NB1643	M{nkRZFJXFNiYYPzZZk>				MoTydWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKE6EMU[0N{Bk\Wyucx?=	NX7IZWxyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
OHS-50	M1jvOpFJXFNiYYPzZZk>				MkLLdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKE:KUz21NEBk\Wyucx?=	M{TyTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
Rh41	M3PiW5FJXFNiYYPzZZk>				NXrRSGtNeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IGLoOFEh[2WubIO=	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
Rh30	NWPZNnE{eUiWUzDhd5NigQ>?				NGH1b3FyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiUnizNEBk\Wyucx?=	NXTxcFVlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
SJ-GBM2	NWr1PZpVeUiWUzDhd5NigQ>?				NYezWnJteUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IGPKMWdDVTJiY3XscJM>	NHvFWoY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
SK-N-MC	MnHMdWhVWyCjc4PhfS=>				M4LQWJFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCVSz3OMW1EKGOnbHzz	M1LWNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
NB-EBc1	NWrsXodleUiWUzDhd5NigQ>?				NGG4XlRyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiTlKtSWJkOSClZXzsdy=>	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
LAN-5	M4jTOZFJXFNiYYPzZZk>				MWDxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhVEGQLUWgZ4VtdHN?	MoTJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
Rh18	M17GU5FJXFNiYYPzZZk>				NIDUNmtyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiUnixPEBk\Wyucx?=	NF:3fXY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	α-SMA / TGF-β / LC-3BI / LC-3B II / Beclin-1 / NF-κB p65; PubMed: 29296191 Oncotarget Western blotting analysed expression of α-SMA, TGF-β, LC-3B, Beclin-1, NF-κB and NF-κBp65 in hepatic stellate cells. caspase-3 / caspase-9 / PARP; PubMed: 25891159 Mol Med Rep EC9706 cell lysates were prepared and subjected to immunoblotting with antibodies against caspase-3, caspase-9 and PARP. The expression ratios in each experiment were determined densitometrically. The results are the averages of triplicate samples. Error bars represent the standard error.P<0.05 vs. IR alone. 3-MA, 3-methyladenine; IR, ionizing radiation; PI, propidum iodide; PARP, poly(ADP ribose) polymerase. VEGF; PubMed: 25891159 Mol Med Rep Effects of autophagy inhibition on the protein expression levels of VEGF. Western blot analysis demonstrated that VEGF protein expression levels were decreased when the EC9706 human esophageal squamous cell carcinoma cells were treated with 3-MA. The results are the averages of triplicate samples. Error bars represent the standard error.P<0.05 vs. IR alone. 3-MA, 3-methyladenine; IR, ionizing radiation; VEGF, vascular endothelial growth factor. APP / BACE1 / ADAM17 / Presenilin 1 / Presenilin 2 / Nicastrin / APH-1 / Pen-2 / LC3-1 / LC3-2; PubMed: 26316755 Neuropsychiatr Dis Treat Presenilin 1, Nicastrin, and Pen-2 were increased with the 3-MA treatment (*P<0.001) while the other component of the γ-secretase complex (APH-1 and Presenilin 2) has no difference. 3-MA, 3-methyladenine; Con, control; APP, amyloid protein precursor.	29296191 25891159 26316755
Immunofluorescence	LC3 / Hif-α / COX2; PubMed: 29039446 Int J Mol Med Chemical interventions of autophagy and ischemic-hypoxic injury, assessed using immunochemical double labeling. Compared with the control group, expression levels of HIF-α and COX2 were altered by chemical intervention. (A) Chemical intervention altered the expression of HIF-α and autophagosmes. Following autophagy antagonist (3-MA) intervention, expression of HIF-α was enhanced, compared with that in the OGD group, and was decreased by the autophagy agonist, rapamycin. In the MHY treatment group, expression of HIF-α was similar to that in the 3-MA group. (B) Chemical intervention showed changes in the expression of COX2 and autophagosomes. Changes in the expression of COX2 were similar to changes in HIF-α. Scale bar, 30 µm. OGD, oxygen-glucose deprivation; HIF-α, hypoxia-inducible factor-α; COX2, cyclooxygenase 2; 3-MA, 3-methyladenine; RP, rapamycin; MHY, MHY1485.	29039446
Growth inhibition assay	Cell viability; PubMed: 26934124 Oncotarget KYSE 180 cells were co-treated with EDHB (40 μg/ml) and various concentrations of 3-MA for 24 h (left) or 48 h (right), and cell viability was determined by WST-8 assays.	26934124

体内研究

3-Methyladenine (3-MA)可以通过对磷酸肌醇3磷酸激酶(PI3K) 的作用来阻断自吞噬, 而PI3K的活性对于自噬体形成早期膜池的成核和组装是必须的。与SAH 处理组相比3-MA并不会改变出血的程度。与SAH +对照成分组相比经过3-MA预处理后会明显加重神经病学症状。3-MA处理会减少自吞噬发生^[5]。相反地,在SAH + 3-MA组里断裂的半胱天冬酶表达量明显上调，与此一致的是与SAH + 对照成分组相比，SAH + 3-MA组中右脑皮层里原位末端标记阳性细胞数量明显增多^[5]。

激酶实验：^[4]	- 合并 Protein degradation assay: HeLa cells are radiolabeled for 24 hours with 0.05 mCi/mL l-[U-¹⁴C]valine. At the end of the labeling period, cells are rinsed three times with PBS. Cells are incubated for the designated times in either full medium or EBSS with or without the presence of 10 mM 3-Methyladenine.
细胞实验：^[2]	- 合并 Cell lines: HeLa 细胞系 Concentrations: 1-10 mM Incubation Time: 3 分钟 Method: 用台盼蓝染色法分析细胞存活率（如HeLa细胞）。简言之, 经过3-MA处理后将贴壁的与漂浮的细胞都用PBS( pH 7.4)重悬，密度控制在每毫升1-2×10⁶。加入等体积的0.4% 台盼蓝并彻底混匀。室温孵育3分钟后用血细胞计数器对细胞计数分析。 (Only for Reference)
动物实验：^[5]	- 合并 Animal Models: 体重 300-350 g 的成年雄性Sprague–Dawley 大鼠 Dosages: 400 nM Administration: 脑室给药 (Only for Reference)

参考文献

- 合并

溶解度 (25°C)

体外	Water	10 mg/mL warmed (67.04 mM)
	Ethanol	4 mg/mL (26.81 mM)
	DMSO	3 mg/mL warmed (20.11 mM)

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download 3-Methyladenine (3-MA) SDF

分子量	149.15
化学式	C₆H₇N₅
CAS号	5142-23-4
储存条件	3年 -20°C 粉状
别名	NSC 66389

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

常见问题及建议解决方法

问题 1：
I'm also wondering whether it can be dissolved in water,or maybe something like culture medium,normal saline solution to form 10mM solution
回答：
As the reference (http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal. pone.0035665), 3-MA, which was found to inhibit autophagy at concentrations ranging from 1 to 10 mM was directly dissolved into the culture medium at the indicated concentrations. And we tested the solubility of S2767, and found the solubility of 3-MA in DMEM is 31 mg/mL at about 40°C.

PI3K Signaling Pathway Map

PI3K Inhibitors with Unique Features

选择性强的PI3K抑制剂

CAL-101 (Idelalisib, GS-1101) : p110δ-selective, IC50=2.5 nM.
选择性强的PI3K抑制剂

TGX-221 : p110β-specific, IC50=5 nM.
活性最高的PI3K抑制剂

BEZ235 (NVP-BEZ235, Dactolisib) : p110α/γ/δ/β, IC50=4 nM/5 nM/7 nM/75 nM.
FDA批准的PI3K抑制剂

CAL-101 (Idelalisib, GS-1101) : Approved by FDA for Relapsed Chronic Lymphocytic Leukemia, Follicular Lymphoma and Small Lymphocytic Lymphoma.
最新的PI3K抑制剂

VS-5584 (SB2343) ^New : Potent and selective dual PI3K/mTOR inhibitor for mTOR, PI3Kα/β/δ/γ with IC50 of 3.4 nM and 2.6-21 nM, respectively.

研究领域

产品类型

定制您的化合物库

3-Methyladenine (3-MA)

客户使用Selleck生产的3-Methyladenine (3-MA)发表文献571篇：

产品安全说明书

PI3K抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download 3-Methyladenine (3-MA) SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

技术支持

常见问题及建议解决方法

PI3K Signaling Pathway Map

PI3K Inhibitors with Unique Features

相关PI3K产品