3-Methyladenine (3-MA)

For research use only. Not for use in humans.

目录号:S2767 别名: NSC 66389 中文名称:3-甲基腺嘌呤

3-Methyladenine (3-MA) Chemical Structure

CAS No. 5142-23-4

3-Methyladenine (3-MA, NSC 66389) 是一种选择性PI3K抑制剂,作用于Vps34PI3Kγ,在 HeLa细胞中IC50分别为25 μM和60 μM;永久性抑制I型PI3K,但对III型PI3K的抑制是短暂的,也会阻断自噬体的形成。3-Methyladenine (3-MA)可成功应用于抑制线粒体自噬。现配现用(加热助溶)

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客户使用Selleck生产的3-Methyladenine (3-MA)发表文献657篇:

产品安全说明书

PI3K抑制剂选择性比较

生物活性

产品描述 3-Methyladenine (3-MA, NSC 66389) 是一种选择性PI3K抑制剂,作用于Vps34PI3Kγ,在 HeLa细胞中IC50分别为25 μM和60 μM;永久性抑制I型PI3K,但对III型PI3K的抑制是短暂的,也会阻断自噬体的形成。3-Methyladenine (3-MA)可成功应用于抑制线粒体自噬。现配现用(加热助溶)
靶点
Vps34 [1]
(HeLa cells)
PI3Kγ [1]
(HeLa cells)
25 μM 60 μM
体外研究

3-MA对Vps34轻微的偏向性可能是由于Vps34中某个特异性的疏水环形结构可以环绕在3-MA的3-甲基基团外面造成的[1] 。据报道对于正常培养和饥饿处理的癌细胞3-MA都能引起细胞死亡。3-MA还可以不通过抑制自吞噬来抑制细胞迁移和入侵,这表明3-MA 除了抑制自吞噬之外还有其它生物功能。3-MA可以造成半胱天冬酶依赖的细胞死亡,这一功能与它对自吞噬的抑制无关。用5mM 3-MA处理葡萄糖饥饿Hela细胞可降低gfp-lc3阳性细胞比例至23%。3-MA处理细胞12到48小时内 LC3-I 的水平上升而LC3-II 水平下降。LC3-I转为为 LC3-II 的过程被3-MA抑制了。 2.5 mM 或5 mM 3-MA 处理HeLa 细胞一天并不影响细胞存活率, 而 10 mM 3-MA 处理一天会造成细胞存活率下降25.0% 。 2.5, 5 或 10 mM 3-MA 处理细胞两天分别使细胞存活率下降 11.5%, 38.0% 和79.4% 。3-MA 降低细胞存活率的作用具有时间和剂量依赖特性。3-MA 明显缩短nocodazole诱导的前中期阻断时间[2]。3-MA 通过抑制自吞噬来抑制SU11274诱导的细胞死亡[3]。 在野生型MEF细胞中延长 3-MA处理时间 (最多 9 小时) 明显造成 LC3 I 到 II 转换。延长 3-MA处理时间会明显增加GFP-LC3的聚集而wortmannin不具有此功能。3-MA介导的LC3 转换和游离 GFP 释放是ATG7依赖的。 3-MA处理会导致 p62 蛋白水平明显升高。即使在Atg5−/− 的MEF细胞中3-MA 也会使p62 水平升高,就像在DOX介导的ATG5缺失的细胞中一样 。3-MA以不同方式抑制 I 型和 III型 PI3K。与野生型细胞相比,在Tsc2−/−细胞中3-MA诱导的 LC3 I 到 LC3 II 转换过程大幅下降。3-MA会破坏mTOR复合物1的拮抗自吞噬功能[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
K562 NInZXnRHfW6ldHnvckBCe3OjeR?= NH20[2oyOG2P NF;Yc5EycA>? M{G1NIRm[3KnYYPld{B1cGViZYjwdoV{e2mxbjDv[kBNSzNvSVmgZY5lKHSqZTDmc5Ju[XSrb36gc4Yh[XW2b4DoZYdwe2:vZYO= Moq5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6NkSwN|coRjJzOE[0NFM4RC:jPh?=
Jurkat MonXSpVv[3Srb36gRZN{[Xl? NILaS4EyOG2P M2jp[FFp MULk[YNz\WG|ZYOgeIhmKGW6cILld5Nqd25ib3[gUGM{NUmLIHHu[EB1cGViZn;ycYF1cW:wIH;mJIF2fG:yaHHnc5NwdWW| M3\2[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOE[0NFM4Lz5{MUi2OFA{PzxxYU6=
HeLa  NWPTdGtwS3m2b4TvfIlkcXS7IFHzd4F6 NH;LOGgzdU1? MVmyOIg> MVvpcohq[mm2ZYOgeIhmKGO7dH;0c5hq[2m2eTDv[kB{cWyrYnnubY4hfG9iSHXMZUBk\Wyucz6= M2XvRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOEe1N|g2Lz5{MUi3OVM5PTxxYU6=
PC12/TetOn NXjhRWhlTnWwY4Tpc44hSXO|YYm= NVG0b|l7OC5zL{HtUS=> M{LTflE5cA>? NGPSXoJt\WGmczD0c{DPuS2|eX6oW3QqKGGlY4XteYxifGmxbjygeI95cWOrdImsJIFv\CCxbHnnc41meiCob4LtZZRqd28EoB?= NYfOSVJTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5NFY3PTlpPkKxPVA3PjV7PD;hQi=>
RMPI8226  NGW1N|BHfW6ldHnvckBCe3OjeR?= MUW1cW0> MljxNYg> NWXWbIpGe3WycILld5NmeyC2aHWgcIV3\Wxib3[gZZV1d3CqYXf5JJVv\GW{IH71eJJq\W62IHTldIxmfGmxbh?= NGfqcFc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUmxOVYzOCd-MkG5NVU3OjB:L3G+
MCF-7 Mkj6SpVv[3Srb36gRZN{[Xl? Mn\sNVBuVQ>? MYK0PIg> NUTH[HZT[myxY3vzJIF2fG:yaHHnfUBqdmS3Y3XkJIJ6KGKxcoTlfo9ucWJ? NYS3OW9uRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5N|E6OzdpPkKxPVMyQTN5PD;hQi=>
HBx  MVfBdI9xfG:|aYOgRZN{[Xl? NHThOJkyOG2P MV20PIg> MlPZSG1UVw>? MkHhbY5kemWjc3XzJINmdGxiZHXheIg> M4TpTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MEKwNFc5Lz5{MkCyNFA4QDxxYU6=
Marc-145 NYnBfGo{TnWwY4Tpc44hSXO|YYm= NVH1N5VVPW2P MVKxNk8zPC9|Nni= NV35PIhmemWmdXPld{B1cGViUGLSV3YhfGm2ZYLzJIFv\CC2aHWgdJJwfGWrbjDlfJBz\XO|aX;u M1HL[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MUG5PVAxLz5{MkGxPVkxODxxYU6=
U937 MYTGeY5kfGmxbjDBd5NigQ>? MUOycW0> NEjGbZQyOmh? MUDk[YNz\WG|ZYOgeIhmKGG3dH;wbIFogSC{YYTpc:Kh MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF3NUG1NEc,OjJzNUWxOVA9N2F-
BGC-823 MlLjSpVv[3Srb36gRZN{[Xl? NFfmXoQ2dU1? M3HseFJp NX;vUncxcW6qaXLpeJMhfGinIILheIUhd2ZiYYX0c5Bp[WerYzDj[Yxtew>? NU\ySGpvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzNlIyPTJpPkKyN|IzOTV{PD;hQi=>
A549 MlS2SpVv[3Srb36gRZN{[Xl? NIToRnIxNjGvTR?= NIn4Z4kzPGh? MXnzeZBxemW|c3XzJHNWOTF{N{StbY5lfWOnZDDj[YxtKGSnYYTo MoHIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2Nk[5OlAoRjJ{NE[2PVYxRC:jPh?=
pDCs MX\GeY5kfGmxbjDBd5NigQ>? NVTLeINzOTCvTR?= NIj5UFUxNjWq MlG0xsBz\WS3Y3XzJJRp\SCrbnT1Z5Rqd25ib3[gTWZPNc7zIHL5JJN{Wk6DNEC= NULMT4FyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzPVY2QTlpPkKyN|k3PTl7PD;hQi=>
HeLa  NIfSUZNCeG:ydH;zbZMhSXO|YYm= NHTpZZc2dU1? NHP6O4IzPGh? M3O1Uolv\HWlZYOgZ4F{eGG|ZT3k[ZBmdmSnboSgZ4VtdCCmZXH0bC=> NIWyV|I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkW0OVEzQCd-MkK1OFUyOjh:L3G+
U251  M4PBWmFxd3C2b4Ppd{BCe3OjeR?= NFHoV5c2dU1? MnHPNlRp MUjpcoNz\WG|ZYOgV|EucW6mdXPl[EBk\WyuIHTlZZRp MoL5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ3N{m3PFgoRjJ{NUe5O|g5RC:jPh?=
MCF-7  M3jBPGFxd3C2b4Ppd{BCe3OjeR?= MYewMlFuVQ>? NYXkXoZXPmh? M3Pn[YVvcGGwY3XzJJNqenSrbn;sMYlv\HWlZXSgZZBweHSxc3nz MkXnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ5NUG5PFkoRjJ{N{WxPVg6RC:jPh?=
PC-3  NU\RRphbSXCxcITvd4l{KEG|c3H5 Ml[4No1O M3vUW|Jp MXjpcoNz\WG|ZYOgU3JKNWmwZIXj[YQh[2WubDDk[YF1cA>? NEXtTnY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mke0OVU5OCd-MkK3OFU2QDB:L3G+
HCT116 NILRSJVCeG:ydH;zbZMhSXO|YYm= M3H3ZVVuVQ>? NFXE[FYzPGh? M3;mcWROW09? M1rRSYVvcGGwY3XzJIFxcWenbnnuMYlv\HWlZXSgZ4VtdCCmZXH0bC=> M1XiPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkK2OVIzLz5{NE[yOlUzOjxxYU6=
U2OS MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYGxNI1O MXqyOIg> MYnpcpRmdnOrZnnld{B1cGViZ4Lve5RpKGmwaHnibZRqd25iaX7keYNm\CCkeTDEc5g> NY\1RVBvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2N|kxOTNpPkK0OlM6ODF|PD;hQi=>
A2780cp MljFRZBweHSxc3nzJGF{e2G7 NXXXbGExOi53bV2= NXjIfYVkOWh? Ml;Z[IRJOk9? NXS0cVZ4\W6qYX7j[ZMh[2m|cHzheIlvNWmwZIXj[YQh[2WubDDk[YF1cA>? MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDhzN{m0Okc,OjR6MUe5OFY9N2F-
HepG2 MXTGeY5kfGmxbjDBd5NigQ>? MoDrOY1O NEP6S5I1cA>? MVrpcoNz\WG|ZYOgZ4VtdHWuYYKgcIV3\Wy|IH;mJGhNyqB? MonVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5MUO1PFcoRjJ2N{GzOVg4RC:jPh?=
Microglia  NHH2NINCeG:ydH;zbZMhSXO|YYm= NILyXJQ2dU1? NXPjZ2lwOjSq M1zE[4Rm[3KnYYPld{BpgXCxeHnhMYlv\HWlZXSgZ4VtdCCmZXH0bC=> MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDhzOE[wNUc,OjR6MUi2NFE9N2F-
MDA-MB 231 MWjBdI9xfG:|aYOgRZN{[Xl? MmC0OY1O M2juUlAvPWh? NUTpV5B6dW:mdXzheIV{KFSxY3;tbY7DtsLiaX7keYNm\CCjcH;weI9{cXN? MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDh|MEe4NUc,OjR6M{C3PFE9N2F-
PANC-1  MnPJRZBweHSxc3nzJGF{e2G7 M{LIV|FuVQ>? NHnYXW01QGh? NES1cIpFVVOR MkKw[Y5p[W6lZYOgZo9zfGW8b33pZk1qdmS3Y3XkJINmdGxidnnhZoltcXS7IHzvd5M> MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDh2MkG1PEc,OjR6NEKxOVg9N2F-
MDA-MB-231 NEjGfVFHfW6ldHnvckBCe3OjeR?= MlnwNo1O NGLv[oY1QGh? NIXTbWtxem:vb4Tld{BVVS2rbnT1Z4VlKGOnbHyg[IVifGh? M3ft[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUewOlc3Lz5{NEm3NFY4PjxxYU6=
MDA-MB-231 M4PkSGZ2dmO2aX;uJGF{e2G7 MWSycW0> NUPFfpdoOjSq MUHpcohq[mm2czDheZRweGijZ4mgbY5lfWOnZDDifUBVVcLi NFO2RWU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm3NFY4Pid-MkS5O|A3PzZ:L3G+
MCF-7  NWHoN4xZTnWwY4Tpc44hSXO|YYm= NGHYRpQzdU1? NHrydGk1QGh? MVfwdo9ud3SnczDUUU1qdmS3Y3XkJINmdGxiZHXheIg> M2PGN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUewOlc3Lz5{NEm3NFY4PjxxYU6=
MCF-7  M3G4Z2Z2dmO2aX;uJGF{e2G7 MlXBNo1O M2rKd|I1cA>? M3X5Z4lvcGmkaYTzJIF2fG:yaHHnfUBqdmS3Y3XkJIJ6KFSPwrC= M3\m[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUewOlc3Lz5{NEm3NFY4PjxxYU6=
HepG2 M4jTcWFxd3C2b4Ppd{BCe3OjeR?= NIfzW3E{dU1? MYi1bC=> MXzy[YR2[2W|IHPlcIwh[XCxcITvd4l{KGmwZIXj[YQh[nliUVTz MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh|NkW5OUc,OjJ6M{[1PVU9N2F-
HeLa Mln6RZBweHSxc3nzJGF{e2G7 NXrTdGNuOTCvTR?= M1XLS|Jp MkLN[IVkemWjc3XzJINmdGxidnnhZoltcXS7IHPvMZRz\WG2bXXueEB4cXSqIGDFTS=> M1O5RlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MECwNVM2Lz5{M{CwNFE{PTxxYU6=
SK-HEP-1 M1vIS2Fxd3C2b4Ppd{BCe3OjeR?= M1raOlExdU1? M376VVFp MYnwdo91\WO2czDh[4FqdnO2IHH1eI9xcGGpeTDhcoQhcW6mdXPld{BieG:ydH;zbZMhcW5iYoXmZYxqdi22cnXheIVlKGOnbHzz M{HqTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OEW4OlQ6Lz5{Mki1PFY1QTxxYU6=
MDA-MB231 MWTGeY5kfGmxbjDBd5NigQ>? NUX4eVJWPW2P MlK0NYg> NITNS5BqdmO{ZXHz[ZMhemW|dnXyZZRzd2xvbXXkbYF1\WRiY3HzdIF{\SCjY4TpeoF1cW:wIHHu[EBk\WyuIHTlZZRp M{fOb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MEi4PFUxLz5{M{C4PFg2ODxxYU6=
PaCa44 NXLtVHhQSXCxcITvd4l{KEG|c3H5 M37qe|IvPW2P NULvTpVWOWh? NWC3PVJSemWmdXPld:Kh\2WwaYDpck1u\WSrYYTl[EBieG:ydH;zbZM> NUC4eldGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOxNlQyOTJpPkKzNVI1OTF{PD;hQi=>
T-47D MVnGeY5kfGmxbjDBd5NigQ>? Mn;ONVBuVQ>? MYqybC=> NIPsN2xqdmirYnn0d{BifXSxcHjh[5kheHKxY3Xzd{BidmRiaX7jdoVie2W|IILhdIFugWOrbjDpcoR2[2WmIHHwc5B1d3Orcx?= NXnFe2dlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFAxOjZpPkKzN|AxODJ4PD;hQi=>
GTL-16  NHPLOVhCeG:ydH;zbZMhSXO|YYm= M1rid|VuVQ>? MU[yOIg> MYLy[YR2[2W|IHPlcIwhfmmjYnnsbZR6KGG|IHPvcZBiemWmIITvJINmdGy|IITy[YF1\WRid3n0bEBOTVRiaX7obYJqfG:{cx?= NG\mSHA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OxN|Q6OCd-MkOzNVM1QTB:L3G+
U251MG  M2f5RWZ2dmO2aX;uJGF{e2G7 NGS3Slc{dU1? M1ezTVFp NYPQfZpUe3WycILld5NmeyCOQ{OtTWkheHKxdHXpckBmgHC{ZYPzbY9v MoD2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|M{i2NVgoRjJ|M{O4OlE5RC:jPh?=
T24 MWXGeY5kfGmxbjDBd5NigQ>? NEDqTXkyOG2P M4X5UVFp NIDudYlz\WS3Y3XzJJRp\SClbHXheoFo\SCxZjDMR|Mh[W[2ZYKgZoFq[2GuaX6geJJm[XSvZX70 NGHiVYU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{O1OFA5OCd-MkOzOVQxQDB:L3G+
HUVECs M3PEb2Z2dmO2aX;uJGF{e2G7 NWfmdI9IO22P M4THPFI1cA>? MlfWZoxw[2u|IITo[UBxem:2ZXP0bZZmKGWoZnXjeEBw\iC{ZYP2[ZJifHKxbDDifUBqdmirYnn0bY5oKGG3dH;wbIFogQ>? MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzN3OEmyPEc,OjN|NUi5Nlg9N2F-
MCF-7  MYnGeY5kfGmxbjDBd5NigQ>? Mn\XOY1O Ml\xNlRp M2fmPIlvcGmkaYTzJJN1[XK4YYTpc44ucW6mdXPl[EBifXSxcHjh[5k> NIDKNIo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{O5OVY4QSd-MkOzPVU3Pzl:L3G+
Hela  MoeySpVv[3Srb36gRZN{[Xl? M1;xdFVuVQ>? MVOyOIg> NVHveVhxcW6qaXLpeJMhe3Sjco\heIlwdi2rbnT1Z4VlKGG3dH;wbIFogQ>? NEDPZZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{O5OVY4QSd-MkOzPVU3Pzl:L3G+
OR6 NXzifFdETnWwY4Tpc44hSXO|YYm= MonRNVBuVQ>? MWi3Nog> NIHzbXV{fXCycnXzd4V{KEiFVjDy[ZBtcWOjdHnvckBidmRiZn;ycYF1cW:wIH;mJIF2fG:yaHHnc5NwdWW| NFPYbGo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{O5OVg4PSd-MkOzPVU5PzV:L3G+
HT-29  M4\EOmZ2dmO2aX;uJGF{e2G7 M1[5N|FuVQ>? Ml3DOFgwQT[q NHP0SlBqdmirYnn0d{BCVVCNIHnu[JVk\XNiYYX0c5Bp[WerYzDj[YxtKGSnYYTo MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzVyOEK3Nkc,OjN3MEiyO|I9N2F-
SH-SY5Y MmfVR5l1d3SxeHnjbZR6KEG|c3H5 NVPVNng{PW2P M2rNWFI1cA>? NYHGXmNCcW6lcnXhd4V{KFCFTjD0c5hq[2m2eR?= Mk\LQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3MkWyOlUoRjJ|NUK1NlY2RC:jPh?=
Saos-2  NGTjWnpCeG:ydH;zbZMhSXO|YYm= NHzUN4YydU1? NHfrb5E6Pmh? MX\pcoNz\WG|ZYOgZ4VtdCCmZXH0bEBqdmS3Y3XkJIJ6KFCFWB?= NFnVR2o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{W2N|E4OSd-MkO1OlMyPzF:L3G+
1321N1 M3\pbWN6fG:2b4jpZ4l1gSCDc4PhfS=> Mk\iOY1O Mm[1NlRp MmX4dJJwfGWldIOgZ4VtdCCjZ3HpcpN1KFCFTj3pcoR2[2WmIITvfIlkcXS7 NUTSd4l5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1NlUzPjVpPkKzOVI2OjZ3PD;hQi=>
A2780 Mlr5RZBweHSxc3nzJGF{e2G7 M3LWNlVuVQ>? NHLtZlAzPGh? NVvLdGhC[2:wdnXyeJMhTlS\N{KwJJdqfGhiQ1TEVEBqdnSxIHHuJIFl\Gm2aY\lJIVn\mWldDD0c5diemS|IHvpcIxqdmdib4\hdolidiClYX7j[ZIh[2WubIO= NXe2S5pMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1PVIzQDFpPkKzOVkzOjhzPD;hQi=>
OV2008 MVvBdI9xfG:|aYOgRZN{[Xl? NFHhXYs2dU1? M4ex[lI1cA>? NYTHV|Nl[2:wdnXyeJMhTlS\N{KwJJdqfGhiQ1TEVEBqdnSxIHHuJIFl\Gm2aY\lJIVn\mWldDD0c5diemS|IHvpcIxqdmdib4\hdolidiClYX7j[ZIh[2WubIO= NWf5NVd5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1PVIzQDFpPkKzOVkzOjhzPD;hQi=>
PC12  MYfGeY5kfGmxbjDBd5NigQ>? NXTndZJDOTCvTR?= NXPpTXdbOjSq MUL3ZZRmeg>? MkXGxsBqdmirYnn0d{BkcHmvb4TyfZB{cW5vbHnr[UBxem:2ZXHzc41idCCjY4Tpeol1gS5? NH\FTVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[wN|k4QSd-MkO2NFM6Pzl:L3G+
SH-SY5Y M1LrSGFxd3C2b4Ppd{BCe3OjeR?= MWS1cW0> NULSXINjOWh? MX3hZo9tcXOqZYOgZ4Vt[XO2cn;sJI5mfXKxcILveIVkfGm4ZTDl[oZm[3R? NHfkXW09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[xPVM6PSd-MkO2NVk{QTV:L3G+
SH-SY5Y NVPtUWNpTnWwY4Tpc44hSXO|YYm= MU[xcW0> NE\tVHczPGh? M3LTT4lvcGmkaYTzJJRp\SCjdYTvdIhi\3liaX7keYNm\CCkeTDUU2NR NYnYbVVCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO3OFMyPDhpPkKzO|Q{OTR6PD;hQi=>
HepG2 MlPLSpVv[3Srb36gRZN{[Xl? MmjINVBuVQ>? MoLPNlRp MXvpcohq[mm2czDzbXRKT0GULTDhcoQhUEKVUz3pcoR2[2WmIHH1eI9xcGGpeR?= MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzhzN{C0NEc,OjN6MUewOFA9N2F-
HeLa MXnGeY5kfGmxbjDBd5NigQ>? M2\2eFExdU1? NFrWcGYzcA>? NH7TToV{fXCycnXzd4V{KEyFMzDJTUBmgHC{ZYPzbZNwdg>? M1j0clxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OE[0O|M5Lz5{M{i2OFc{QDxxYU6=
HONE-1  NFTqfIFHfW6ldHnvckBCe3OjeR?= NGrBcFA2dU1? NX7uUlFHOWh? M2PsdpJmeHKnc4Pld{A3ei2vZXTpZZRm\CCUT2OgdJJw\HWldHnvci=> MnzQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6OUKzOVgoRjJ|OEmyN|U5RC:jPh?=
MCF7 NFLYemNHfW6ldHnvckBCe3OjeR?= NILyfpk2dU1? NUnlWYN[OjSq M4rMR4lv[3KnYYPld{BEfU9iaX7keYNm\CClZXzsJIRm[XSq M17USlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OU[yOlI6Lz5{M{m2NlYzQTxxYU6=
HO8910 MXjBdI9xfG:|aYOgRZN{[Xl? NHHpbIIyOG2P MXGxNog> NWG0clE{\W6qYX7j[ZMhSjF7LXnu[JVk\WRiYYDvdJRwe2l? MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl6M{[xNEc,OjN7OEO2NVA9N2F-
SMMC-7721 NH\yfHZCeG:ydH;zbZMhSXO|YYm= NYWwOVNbPW2P NVH5W29lOjSq MYjheJRmdnWjdHXzJHRPTi4QsTDwdo91\WO2aX;uJIFo[Wmwc4Sgd4VzfW1ic4ThdpZifGmxbj3t[YRq[XSnZDDhdI9xfG:|aYO= MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB4Nk[5N{c,OjRyNk[2PVM9N2F-
Hep3B NF\TdmdCeG:ydH;zbZMhSXO|YYm= NYPnWZFEPW2P NYHJNpZyOjSq M{fWWoF1fGWwdXH0[ZMhXE6ILd8xJJBzd3SnY4Tpc44h[WejaX7zeEB{\XK3bTDzeIFzfmG2aX;uMY1m\GmjdHXkJIFxd3C2b4Ppdy=> NYq4dpE1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwOlY3QTNpPkK0NFY3Pjl|PD;hQi=>
H460 NVPkTYVXTnWwY4Tpc44hSXO|YYm= NF\GTGoyOG2P NVPYVpZOPGh? MmG3bY5kemWjc3XzJINqe3CuYYTpck1qdmS3Y3XkJINmdGxiZHXheIg> MkfRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzN{OyNFgoRjJ2MUezNlA5RC:jPh?=
A549 NH3qR|dHfW6ldHnvckBCe3OjeR?= MVSxNI1O MmjsOIg> NF71PWFqdmirYnn0d{BifXSxcHjh[5khcW6mdXPl[EBjgSCrcoLh[IlifGmxbh?= MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDF2MkezOUc,OjRzNEK3N|U9N2F-
H1299  MlrTSpVv[3Srb36gRZN{[Xl? M1jEeFExdU1? M4rVN|Rp MnHUbY5kemWjc3XzJINqe3CuYYTpck1qdmS3Y3XkJINmdGxiZHXheIg> M2HkRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUezNlA5Lz5{NEG3N|IxQDxxYU6=
WiDr MXXGeY5kfGmxbjDBd5NigQ>? MnXpNVBuVQ>? MmHTNYg> NEP0OZpqdmirYnn0d{BRS0KOLXnu[JVk\WRiTFOzJGlKKGW6cILld5Nqd25? M2[wR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUmwOFg6Lz5{NEG5NFQ5QTxxYU6=
LoVo  NHzudppCeG:ydH;zbZMhSXO|YYm= MX21cW0> M3LwbVQ5cA>? NWPIO41E\W6qYX7j[ZMhTEODLXnu[JVk\WRiYYDvdJRwe2m|Lh?= M2rxTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MkCxPFEzLz5{NEKwNVgyOjxxYU6=
HepG2 E47 MmPOSpVv[3Srb36gRZN{[Xl? M3;4V|IvPW2P MkHNOFhp M3u3Solv[3KnYYPld{B1cGVidH;4bYNqfHlib3[gRWEtKEKVTzygZY5lKEOFbES= MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDJ5M{ezPEc,OjR{N{O3N|g9N2F-
RKO MWnGeY5kfGmxbjDBd5NigQ>? MnjZNo1O M3XVcFFp MmPvSG1UVw>? NFLhTIdmdmijbnPld{Bk\WyuIHTlZZRpKGK7IHflcIRidmGveXPpci=> NIXRNXY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEK5NVc4Pyd-MkSyPVE4Pzd:L3G+
Hep3B MlS1RZBweHSxc3nzJGF{e2G7 NYLNboJ5Om2P NEi0VHQyOmh? NHHzTJVFVVOR NV3VeVY6cW6qaXLpeJMhSVqGOEC1OU1qdmS3Y3XkJINmdGxiZHXheIg> NYrPfGpCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyPVc{ODBpPkK0Nlk4OzByPD;hQi=>
ACHN-5968 Mn\VRZBweHSxc3nzJGF{e2G7 MY[1cW0> MUezbC=> M3;CSYVvcGGwY3XzJJBi[2yrdHH4[YwudWWmaXH0[YQh[XCxcITvd4l{yqB? NELJVnk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEOwOVYxPCd-MkSzNFU3ODR:L3G+
Huh7 NGj3c2JCeG:ydH;zbZMhSXO|YYm= NGr2UGkzdU1? MVmxNog> NGq3V5JFVVOR MWnpcohq[mm2czDBXmQ5ODV3LXnu[JVk\WRiY3XscEBl\WG2aB?= NILMO5k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEK5O|MxOCd-MkSyPVc{ODB:L3G+
UOK257 MULBdI9xfG:|aYOgRZN{[Xl? NVKxWlJFPW2P M{PYUFNp MmDk[Y5p[W6lZYOgdIFkdGm2YYjlcE1u\WSrYYTl[EBieG:ydH;zbZPDqA>? MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDNyNU[wOEc,OjR|MEW2NFQ9N2F-
ECSCs  NGjnS4pCeG:ydH;zbZMhSXO|YYm= NYn2ZYVGOTCvTR?= NVjmSpNFPGh? NVPzR4t5\GWlcnXhd4V{KHKjcHHtfYNqdi22cnXheIVlKGGyb4D0c5Nqew>? MkXiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR|MUmxNFkoRjJ2M{G5NVA6RC:jPh?=
MCF-7  NEj0c21HfW6ldHnvckBCe3OjeR?= MmH3NVBuVQ>? MmDRNlRp NFP4RllqdmirYnn0d{B1cGViYYX0c5Bp[We7IHnu[JVk\WRiYomgZ4hmdW:2aHXyZZB6KGS{dXfz MnfHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR|MUW1O|goRjJ2M{G1OVc5RC:jPh?=
SGC-7901  NInTVY9CeG:ydH;zbZMhSXO|YYm= M3vOZVJuVQ>? NGrwdWUycA>? NYrBSG9ncW6lcnXhd4V{KEODLUSgbY5lfWOnZDDhdI9xfG:|aYO= MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN{MUO0NEc,OjR|MkGzOFA9N2F-
SMMC-7721 MYTBdI9xfG:|aYOgRZN{[Xl? MXiycW0> M1PIb|Fp MX\pcoNz\WG|ZYOgR2EuPCCrbnT1Z4VlKGGyb4D0c5Nqew>? MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN{MUO0NEc,OjR|MkGzOFA9N2F-
T24 MnjoRZBweHSxc3nzJGF{e2G7 NV;IWW1UPW2P NES2c4kyNjWq NF\ZcZNxd3SnboTpZZRmeyClZXzlZ495cWJvaX7keYNm\CCjcH;weI9{cXN? MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN2OUG3Okc,OjR|N