3-Methyladenine (3-MA)

For research use only. Not for use in humans.

目录号:S2767 别名: NSC 66389 中文名称:3-甲基腺嘌呤

3-Methyladenine (3-MA) Chemical Structure

CAS No. 5142-23-4

3-Methyladenine (3-MA, NSC 66389) 是一种选择性PI3K抑制剂,作用于Vps34PI3Kγ,在 HeLa细胞中IC50分别为25 μM和60 μM;永久性抑制I型PI3K,但对III型PI3K的抑制是短暂的,也会阻断自噬体的形成。3-Methyladenine (3-MA)可成功应用于抑制线粒体自噬。现配现用(加热助溶)

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客户使用Selleck生产的3-Methyladenine (3-MA)发表文献625篇:

产品安全说明书

PI3K抑制剂选择性比较

生物活性

产品描述 3-Methyladenine (3-MA, NSC 66389) 是一种选择性PI3K抑制剂,作用于Vps34PI3Kγ,在 HeLa细胞中IC50分别为25 μM和60 μM;永久性抑制I型PI3K,但对III型PI3K的抑制是短暂的,也会阻断自噬体的形成。3-Methyladenine (3-MA)可成功应用于抑制线粒体自噬。现配现用(加热助溶)
靶点
Vps34 [1]
(HeLa cells)
PI3Kγ [1]
(HeLa cells)
25 μM 60 μM
体外研究

3-MA对Vps34轻微的偏向性可能是由于Vps34中某个特异性的疏水环形结构可以环绕在3-MA的3-甲基基团外面造成的[1] 。据报道对于正常培养和饥饿处理的癌细胞3-MA都能引起细胞死亡。3-MA还可以不通过抑制自吞噬来抑制细胞迁移和入侵,这表明3-MA 除了抑制自吞噬之外还有其它生物功能。3-MA可以造成半胱天冬酶依赖的细胞死亡,这一功能与它对自吞噬的抑制无关。用5mM 3-MA处理葡萄糖饥饿Hela细胞可降低gfp-lc3阳性细胞比例至23%。3-MA处理细胞12到48小时内 LC3-I 的水平上升而LC3-II 水平下降。LC3-I转为为 LC3-II 的过程被3-MA抑制了。 2.5 mM 或5 mM 3-MA 处理HeLa 细胞一天并不影响细胞存活率, 而 10 mM 3-MA 处理一天会造成细胞存活率下降25.0% 。 2.5, 5 或 10 mM 3-MA 处理细胞两天分别使细胞存活率下降 11.5%, 38.0% 和79.4% 。3-MA 降低细胞存活率的作用具有时间和剂量依赖特性。3-MA 明显缩短nocodazole诱导的前中期阻断时间[2]。3-MA 通过抑制自吞噬来抑制SU11274诱导的细胞死亡[3]。 在野生型MEF细胞中延长 3-MA处理时间 (最多 9 小时) 明显造成 LC3 I 到 II 转换。延长 3-MA处理时间会明显增加GFP-LC3的聚集而wortmannin不具有此功能。3-MA介导的LC3 转换和游离 GFP 释放是ATG7依赖的。 3-MA处理会导致 p62 蛋白水平明显升高。即使在Atg5−/− 的MEF细胞中3-MA 也会使p62 水平升高,就像在DOX介导的ATG5缺失的细胞中一样 。3-MA以不同方式抑制 I 型和 III型 PI3K。与野生型细胞相比,在Tsc2−/−细胞中3-MA诱导的 LC3 I 到 LC3 II 转换过程大幅下降。3-MA会破坏mTOR复合物1的拮抗自吞噬功能[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
K562 NGLhOlVHfW6ldHnvckBCe3OjeR?= M{iwRVExdU1? MknqNYg> MXTk[YNz\WG|ZYOgeIhmKGW6cILld5Nqd25ib3[gUGM{NUmLIHHu[EB1cGViZn;ycYF1cW:wIH;mJIF2fG:yaHHnc5NwdWW| MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTh4NECzO{c,OjF6NkSwN|c9N2F-
Jurkat NUDkfZZETnWwY4Tpc44hSXO|YYm= MWCxNI1O Mk[zNYg> NVThWpV6\GWlcnXhd4V{KHSqZTDlfJBz\XO|aX;uJI9nKEyFMz3JTUBidmRidHjlJIZwem2jdHnvckBw\iCjdYTvdIhi\2:|b33ldy=> M1zLdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOE[0NFM4Lz5{MUi2OFA{PzxxYU6=
HeLa  M3WySGN6fG:2b4jpZ4l1gSCDc4PhfS=> NYXYUHhFOm2P NIW5T3kzPGh? MnLObY5pcWKrdHXzJJRp\SCleYTveI95cWOrdImgc4Yhe2muaXLpcolvKHSxIFjlUIEh[2WubIOu NI[5O449[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUi3OVM5PSd-MkG4O|U{QDV:L3G+
PC12/TetOn MUfGeY5kfGmxbjDBd5NigQ>? NXrqcHhzOC5zL{HtUS=> M1vVWlE5cA>? MmX2cIVi\HNidH:g{tEue3mwKGfULUBi[2O3bYXsZZRqd25uIITvfIlkcXS7LDDhcoQhd2yrZ3;t[ZIh\m:{bXH0bY9vyqB? NUCz[GZCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5NFY3PTlpPkKxPVA3PjV7PD;hQi=>
RMPI8226  MYnGeY5kfGmxbjDBd5NigQ>? NEXh[482dU1? NXvpZ2tWOWh? MXfzeZBxemW|c3XzJJRp\SCuZY\lcEBw\iCjdYTvdIhi\3lidX7k[ZIhdnW2cnnlcpQh\GWybHX0bY9v M2HGbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOUG1OlIxLz5{MUmxOVYzODxxYU6=
MCF-7 M2jpRWZ2dmO2aX;uJGF{e2G7 MY[xNI1O MVu0PIg> MUDicI9kc3NiYYX0c5Bp[We7IHnu[JVk\WRiYomgZo9zfGW8b33pZi=> Mn;BQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7M{G5N|coRjJzOUOxPVM4RC:jPh?=
HBx  MoX0RZBweHSxc3nzJGF{e2G7 MVexNI1O MWK0PIg> MnLVSG1UVw>? NILlcGJqdmO{ZXHz[ZMh[2WubDDk[YF1cA>? MlfDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyMkCwO|goRjJ{MEKwNFc5RC:jPh?=
Marc-145 M4W5PWZ2dmO2aX;uJGF{e2G7 NIfDZpg2dU1? M3vpRlEzNzJ2L{O2bC=> MlHwdoVlfWOnczD0bIUhWFKUU2[geIl1\XK|IHHu[EB1cGVicILveIVqdiCneIDy[ZN{cW:w MorEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzMUm5NFAoRjJ{MUG5PVAxRC:jPh?=
U937 NEn6R3hHfW6ldHnvckBCe3OjeR?= NX63N2RVOm2P MXmxNog> NEnrN2Vl\WO{ZXHz[ZMhfGinIHH1eI9xcGGpeTDyZZRqd8Li MoTtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzNUWxOVAoRjJ{MUW1NVUxRC:jPh?=
BGC-823 MVLGeY5kfGmxbjDBd5NigQ>? M2nkOVVuVQ>? MYOybC=> MWPpcohq[mm2czD0bIUhemG2ZTDv[kBifXSxcHjh[4lkKGOnbHzz MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN{MkG1Nkc,OjJ|MkKxOVI9N2F-
A549 NE\pcmRHfW6ldHnvckBCe3OjeR?= NXPvdoxSOC5zbV2= NHPkfIEzPGh? Mlzsd5VxeHKnc4Pld{BUXTFzMke0MYlv\HWlZXSgZ4VtdCCmZXH0bC=> NIHaWoQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkS2Olk3OCd-MkK0OlY6PjB:L3G+
pDCs NUPvO2RvTnWwY4Tpc44hSXO|YYm= NH;TUoEyOG2P MkfQNE42cA>? NUDzd2hlyqC{ZXT1Z4V{KHSqZTDpcoR2[3Srb36gc4YhUU[QLd8xJIJ6KHO|Ul7BOFA> M2DFZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{m2OVk6Lz5{MkO5OlU6QTxxYU6=
HeLa  M2HDc2Fxd3C2b4Ppd{BCe3OjeR?= NHvwZ3Q2dU1? M1XMflI1cA>? MW\pcoR2[2W|IHPhd5Bie2VvZHXw[Y5l\W62IHPlcIwh\GWjdHi= M3X5O|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NUS1NVI5Lz5{MkW0OVEzQDxxYU6=
U251  NVPMSWZvSXCxcITvd4l{KEG|c3H5 MY[1cW0> MXmyOIg> MmDSbY5kemWjc3XzJHMyNWmwZIXj[YQh[2WubDDk[YF1cA>? MkW1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ3N{m3PFgoRjJ{NUe5O|g5RC:jPh?=
MCF-7  MYfBdI9xfG:|aYOgRZN{[Xl? M{HSVVAvOW2P NUHobYtwPmh? MULlcohidmOnczDzbZJ1cW6xbD3pcoR2[2WmIHHwc5B1d3Orcx?= MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjd3MUm4PUc,OjJ5NUG5PFk9N2F-
PC-3  M1zZSmFxd3C2b4Ppd{BCe3OjeR?= NIfSUXAzdU1? NFzR[lkzcA>? NFrC[2lqdmO{ZXHz[ZMhV1KLLXnu[JVk\WRiY3XscEBl\WG2aB?= M4LsdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{N{S1OVgxLz5{Mke0OVU5ODxxYU6=
HCT116 Mn\BRZBweHSxc3nzJGF{e2G7 MV21cW0> NHvhcoEzPGh? MnfLSG1UVw>? M3fWZYVvcGGwY3XzJIFxcWenbnnuMYlv\HWlZXSgZ4VtdCCmZXH0bC=> MnG0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4Mk[1NlIoRjJ2NkK2OVIzRC:jPh?=
U2OS M4jsOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVexNI1O NWnGZYhbOjSq NHToT4JqdnSnboPp[olmeyC2aHWg[5Jwf3SqIHnubIljcXSrb36gbY5lfWOnZDDifUBFd3h? M2Cye|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkO5NFE{Lz5{NE[zPVAyOzxxYU6=
A2780cp MWnBdI9xfG:|aYOgRZN{[Xl? MnTGNk42dU1? NIHwRWUycA>? MYTk[GgzVw>? MoDS[Y5p[W6lZYOgZ4l{eGyjdHnuMYlv\HWlZXSgZ4VtdCCmZXH0bC=> NFP0NFA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEixO|k1Pid-MkS4NVc6PDZ:L3G+
HepG2 MkfRSpVv[3Srb36gRZN{[Xl? Ml\oOY1O M3j2SFRp MmH4bY5kemWjc3XzJINmdGy3bHHyJIxmfmWuczDv[kBJVMLi M1n4Z|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{GzOVg4Lz5{NEexN|U5PzxxYU6=
Microglia  MX3BdI9xfG:|aYOgRZN{[Xl? Mor3OY1O MlTpNlRp NYrENmhw\GWlcnXhd4V{KGi7cH;4bYEucW6mdXPl[EBk\WyuIHTlZZRp MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDhzOE[wNUc,OjR6MUi2NFE9N2F-
MDA-MB 231 NWntW3VNSXCxcITvd4l{KEG|c3H5 NVO3fmlDPW2P M1\oW|AvPWh? NYHzcYc6dW:mdXzheIV{KFSxY3;tbY7DtsLiaX7keYNm\CCjcH;weI9{cXN? NYLEXnV6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4N|A4QDFpPkK0PFMxPzhzPD;hQi=>
PANC-1  MoXPRZBweHSxc3nzJGF{e2G7 MlTWNY1O NF;xTVY1QGh? NWXDbGFyTE2VTx?= MUjlcohidmOnczDic5J1\XqxbXniMYlv\HWlZXSgZ4VtdCC4aXHibYxqfHlibH;zdy=> M4C3dVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OESyNVU5Lz5{NEi0NlE2QDxxYU6=
MDA-MB-231 M3PWUmZ2dmO2aX;uJGF{e2G7 MlvqNo1O MkiyOFhp NV\ZNHIzeHKxbX;0[ZMhXE1vaX7keYNm\CClZXzsJIRm[XSq MnrmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7N{C2O|YoRjJ2OUewOlc3RC:jPh?=
MDA-MB-231 NYD1cXFbTnWwY4Tpc44hSXO|YYm= NYrmPY1POm2P M1L2V|I1cA>? NV;mZ2Z6cW6qaXLpeJMh[XW2b4DoZYd6KGmwZIXj[YQh[nliVF5CpC=> NXHo[pRsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5O|A3PzZpPkK0PVcxPjd4PD;hQi=>
MCF-7  NH7ReWFHfW6ldHnvckBCe3OjeR?= MkT3No1O M1ixclQ5cA>? NEWxepFxem:vb4Tld{BVVS2rbnT1Z4VlKGOnbHyg[IVifGh? MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl5ME[3Okc,OjR7N{C2O|Y9N2F-
MCF-7  MnzISpVv[3Srb36gRZN{[Xl? NEDScGszdU1? MWWyOIg> NYLzNWRMcW6qaXLpeJMh[XW2b4DoZYd6KGmwZIXj[YQh[nliVF5CpC=> M1HnfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUewOlc3Lz5{NEm3NFY4PjxxYU6=
HepG2 NEDDbo1CeG:ydH;zbZMhSXO|YYm= NVfCOpBwO22P M4ftO|Vp NV\nfZVvemWmdXPld{Bk\WyuIHHwc5B1d3OrczDpcoR2[2WmIHL5JHFFew>? MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh|NkW5OUc,OjJ6M{[1PVU9N2F-
HeLa MXHBdI9xfG:|aYOgRZN{[Xl? NFPXWYIyOG2P M37pUlJp MoXq[IVkemWjc3XzJINmdGxidnnhZoltcXS7IHPvMZRz\WG2bXXueEB4cXSqIGDFTS=> NIn0fpk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{CwNFE{PSd-MkOwNFAyOzV:L3G+
SK-HEP-1 NFTWUoRCeG:ydH;zbZMhSXO|YYm= NYTXW41nOTCvTR?= NEDWNIEycA>? NIXVc4lxem:2ZXP0d{Bi\2GrboP0JIF2fG:yaHHnfUBidmRiaX7keYNmeyCjcH;weI9{cXNiaX6gZpVn[Wyrbj30doVifGWmIHPlcIx{ M{\2VlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OEW4OlQ6Lz5{Mki1PFY1QTxxYU6=
MDA-MB231 NH7TSFZHfW6ldHnvckBCe3OjeR?= MUC1cW0> MUCxbC=> NHPWNJhqdmO{ZXHz[ZMhemW|dnXyZZRzd2xvbXXkbYF1\WRiY3HzdIF{\SCjY4TpeoF1cW:wIHHu[EBk\WyuIHTlZZRp Mke1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyOEi4OVAoRjJ|MEi4PFUxRC:jPh?=
PaCa44 M1;wXWFxd3C2b4Ppd{BCe3OjeR?= NUfi[GNLOi53bV2= MlPGNYg> NWG5ZoRZemWmdXPld:Kh\2WwaYDpck1u\WSrYYTl[EBieG:ydH;zbZM> MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzF{NEGxNkc,OjNzMkSxNVI9N2F-
T-47D NYS0bJkzTnWwY4Tpc44hSXO|YYm= MU[xNI1O NFzicoYzcA>? MUTpcohq[mm2czDheZRweGijZ4mgdJJw[2W|czDhcoQhcW6lcnXhd4V{KHKjcHHtfYNqdiCrbnT1Z4VlKGGyb4D0c5Nqew>? NIrlVFE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwNFAzPid-MkOzNFAxOjZ:L3G+
GTL-16  NFfCTHNCeG:ydH;zbZMhSXO|YYm= NVq0NFJJPW2P Mom0NlRp MYLy[YR2[2W|IHPlcIwhfmmjYnnsbZR6KGG|IHPvcZBiemWmIITvJINmdGy|IITy[YF1\WRid3n0bEBOTVRiaX7obYJqfG:{cx?= MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{S5NEc,OjN|MUO0PVA9N2F-
U251MG  MYjGeY5kfGmxbjDBd5NigQ>? M1\R[FNuVQ>? MVWxbC=> M3q3eZN2eHC{ZYPz[ZMhVEN|LVnJJJBzd3SnaX6g[ZhxemW|c3nvci=> MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzN|OE[xPEc,OjN|M{i2NVg9N2F-
T24 MXXGeY5kfGmxbjDBd5NigQ>? MX:xNI1O Mn\BNYg> M2D4bpJm\HWlZYOgeIhmKGOuZXH2ZYdmKG:oIFzDN{Bi\nSncjDiZYlk[WyrbjD0doVifG2nboS= NVnKNIMzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzOVQxQDBpPkKzN|U1ODhyPD;hQi=>
HUVECs MY\GeY5kfGmxbjDBd5NigQ>? MnnmN41O MYmyOIg> Ml73Zoxw[2u|IITo[UBxem:2ZXP0bZZmKGWoZnXjeEBw\iC{ZYP2[ZJifHKxbDDifUBqdmirYnn0bY5oKGG3dH;wbIFogQ>? MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzN3OEmyPEc,OjN|NUi5Nlg9N2F-
MCF-7  M2\0VmZ2dmO2aX;uJGF{e2G7 NYi1[mhIPW2P MYeyOIg> M4jnZYlvcGmkaYTzJJN1[XK4YYTpc44ucW6mdXPl[EBifXSxcHjh[5k> MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzN7NU[3PUc,OjN|OUW2O|k9N2F-
Hela  MYHGeY5kfGmxbjDBd5NigQ>? NUS3ZWRsPW2P MmPGNlRp NU\tWnI1cW6qaXLpeJMhe3Sjco\heIlwdi2rbnT1Z4VlKGG3dH;wbIFogQ>? Mon4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|OUW2O|koRjJ|M{m1Olc6RC:jPh?=
OR6 MnH3SpVv[3Srb36gRZN{[Xl? NHXOTJoyOG2P M2PpVFczcA>? NGTnTpZ{fXCycnXzd4V{KEiFVjDy[ZBtcWOjdHnvckBidmRiZn;ycYF1cW:wIH;mJIF2fG:yaHHnc5NwdWW| NUXHN5B1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzPVU5PzVpPkKzN|k2QDd3PD;hQi=>
HT-29  M{T0UmZ2dmO2aX;uJGF{e2G7 NWfHcXJpOW2P MU[0PE86Pmh? MVzpcohq[mm2czDBUXBMKGmwZIXj[ZMh[XW2b4DoZYdq[yClZXzsJIRm[XSq M3nWclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NUC4NlczLz5{M{WwPFI4OjxxYU6=
SH-SY5Y MlTMR5l1d3SxeHnjbZR6KEG|c3H5 NX7Lc|FHPW2P MlvjNlRp M4fkbYlv[3KnYYPld{BRS05idH;4bYNqfHl? NYTFPJBZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1NlUzPjVpPkKzOVI2OjZ3PD;hQi=>
Saos-2  NGfFZ5JCeG:ydH;zbZMhSXO|YYm= NXzmboRXOW2P MWW5Oog> M4DST4lv[3KnYYPld{Bk\WyuIHTlZZRpKGmwZIXj[YQh[nliUFPY M2HEN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NU[zNVcyLz5{M{W2N|E4OTxxYU6=
1321N1 NV6yWJZFS3m2b4TvfIlkcXS7IFHzd4F6 M2jMe|VuVQ>? M2HTSlI1cA>? NYPrTGVZeHKxdHXjeJMh[2WubDDh[4FqdnO2IGDDUk1qdmS3Y3XkJJRwgGmlaYT5 NX\5cWhURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1NlUzPjVpPkKzOVI2OjZ3PD;hQi=>
A2780 NYT1OFdXSXCxcITvd4l{KEG|c3H5 MmD6OY1O MnjSNlRp NXzDcY9R[2:wdnXyeJMhTlS\N{KwJJdqfGhiQ1TEVEBqdnSxIHHuJIFl\Gm2aY\lJIVn\mWldDD0c5diemS|IHvpcIxqdmdib4\hdolidiClYX7j[ZIh[2WubIO= NF\vTog9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{W5NlI5OSd-MkO1PVIzQDF:L3G+
OV2008 M1zJV2Fxd3C2b4Ppd{BCe3OjeR?= MlL4OY1O NVS0R3VxOjSq Mn\xZ49vfmW{dIOgSnR[PzJyIIfpeIghS0SGUDDpcpRwKGGwIHHk[Il1cX[nIHXm[oVkfCC2b4fhdoR{KGurbHzpcochd3[jcnnhckBk[W6lZYKgZ4VtdHN? M3n5N|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NUmyNlgyLz5{M{W5NlI5OTxxYU6=
PC12  MWfGeY5kfGmxbjDBd5NigQ>? NVO1d|FMOTCvTR?= MYmyOIg> NHfJfYl4[XSnch?= MUpCpIlvcGmkaYTzJINpgW2xdIL5dJNqdi2uaXvlJJBzd3SnYYPvcYFtKGGldHn2bZR6Ng>? Mnq3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MEO5O|koRjJ|NkCzPVc6RC:jPh?=
SH-SY5Y NVTDdYx{SXCxcITvd4l{KEG|c3H5 NHm1N5Y2dU1? NHGweVgycA>? M4XTdoFjd2yrc3jld{Bk\Wyjc4Tyc4whdmW3cn;wdo91\WO2aY\lJIVn\mWldB?= MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZzOUO5OUc,OjN4MUmzPVU9N2F-
SH-SY5Y MUfGeY5kfGmxbjDBd5NigQ>? M{jKbVFuVQ>? NFfpbZEzPGh? MmmxbY5pcWKrdIOgeIhmKGG3dH;wbIFogSCrbnT1Z4VlKGK7IGTPR3A> MlPFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5NEOxOFgoRjJ|N{SzNVQ5RC:jPh?=
HepG2 NV3zT3l3TnWwY4Tpc44hSXO|YYm= MnKwNVBuVQ>? NIXDUoczPGh? Mk\YbY5pcWKrdIOgd4lVUUeDUj2gZY5lKEiEU2OtbY5lfWOnZDDheZRweGijZ4m= MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzhzN{C0NEc,OjN6MUewOFA9N2F-
HeLa MXzGeY5kfGmxbjDBd5NigQ>? MnfWNVBuVQ>? NHraVVMzcA>? M170SJN2eHC{ZYPz[ZMhVEN|IFnJJIV5eHKnc4Ppd49v MmfoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6NkS3N|goRjJ|OE[0O|M5RC:jPh?=
HONE-1  NH7ESVRHfW6ldHnvckBCe3OjeR?= MX21cW0> MYKxbC=> NWnSSYtUemWycnXzd4V{KD[{LX3l[IlifGWmIGLPV{Bxem:mdXP0bY9v MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzh7MkO1PEc,OjN6OUKzOVg9N2F-
MCF7 M1nYR2Z2dmO2aX;uJGF{e2G7 MVG1cW0> NVHycZd{OjSq M4ewSIlv[3KnYYPld{BEfU9iaX7keYNm\CClZXzsJIRm[XSq MoX2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkK2NlkoRjJ|OU[yOlI6RC:jPh?=
HO8910 M2mwc2Fxd3C2b4Ppd{BCe3OjeR?= MWSxNI1O MUSxNog> MUXlcohidmOnczDCNVkucW6mdXPl[EBieG:ydH;zbS=> M3jKflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OUizOlExLz5{M{m4N|YyODxxYU6=
SMMC-7721 MUHBdI9xfG:|aYOgRZN{[Xl? MlnGOY1O NEjFTYMzPGh? NGHTWI9ifHSnboXheIV{KFSQRj5OtUBxem:2ZXP0bY9vKGGpYXnud5Qhe2W{dX2gd5Rien[jdHnvck1u\WSrYYTl[EBieG:ydH;zbZM> MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB4Nk[5N{c,OjRyNk[2PVM9N2F-
Hep3B M3jhSGFxd3C2b4Ppd{BCe3OjeR?= M1frZVVuVQ>? M2L5NFI1cA>? MWLheJRmdnWjdHXzJHRPTi4QsTDwdo91\WO2aX;uJIFo[Wmwc4Sgd4VzfW1ic4ThdpZifGmxbj3t[YRq[XSnZDDhdI9xfG:|aYO= NWezWnJSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwOlY3QTNpPkK0NFY3Pjl|PD;hQi=>
H460 Mm\ESpVv[3Srb36gRZN{[Xl? NEn0So0yOG2P NFXkZ2g1cA>? NEL5[Y9qdmO{ZXHz[ZMh[2m|cHzheIlvNWmwZIXj[YQh[2WubDDk[YF1cA>? NIfMfI89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEG3N|IxQCd-MkSxO|MzODh:L3G+
A549 MX\GeY5kfGmxbjDBd5NigQ>? NYjGZllQOTCvTR?= NGjKc4U1cA>? Mk\PbY5pcWKrdIOgZZV1d3CqYXf5JIlv\HWlZXSgZpkhcXK{YXTpZZRqd25? M2K5NFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUSyO|M2Lz5{NEG0Nlc{PTxxYU6=
H1299  MV3GeY5kfGmxbjDBd5NigQ>? MYKxNI1O NGHxW4s1cA>? MWLpcoNz\WG|ZYOgZ4l{eGyjdHnuMYlv\HWlZXSgZ4VtdCCmZXH0bC=> MlGyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzN{OyNFgoRjJ2MUezNlA5RC:jPh?=
WiDr MmjCSpVv[3Srb36gRZN{[Xl? NHrKXWcyOG2P NHfXfnMycA>? M{HOVYlvcGmkaYTzJHBESkxvaX7keYNm\CCOQ{OgTWkh\XiycnXzd4lwdg>? NIXKS5I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEG5NFQ5QSd-MkSxPVA1QDl:L3G+
LoVo  Ml\ZRZBweHSxc3nzJGF{e2G7 NEfHTGo2dU1? NIrN[5I1QGh? NFHYVoJmdmijbnPld{BFS0FvaX7keYNm\CCjcH;weI9{cXNw M37xfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MkCxPFEzLz5{NEKwNVgyOjxxYU6=
HepG2 E47 NWe5SGwzTnWwY4Tpc44hSXO|YYm= MnXhNk42dU1? NVrnUW5VPDiq MXLpcoNz\WG|ZYOgeIhmKHSxeHnjbZR6KG:oIFHBMEBDW09uIHHu[EBES2x2 M4jLfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MkezO|M5Lz5{NEK3N|c{QDxxYU6=
RKO NXHwWXR5TnWwY4Tpc44hSXO|YYm= M3HU[VJuVQ>? M4T2NlFp NHrBO5NFVVOR Ml7R[Y5p[W6lZYOgZ4VtdCCmZXH0bEBjgSCpZXzkZY5idXmlaX6= M{\lZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MkmxO|c4Lz5{NEK5NVc4PzxxYU6=
Hep3B MVHBdI9xfG:|aYOgRZN{[Xl? NHHGO40zdU1? MVyxNog> NUntbGZTTE2VTx?= MnPFbY5pcWKrdIOgRXpFQDB3NT3pcoR2[2WmIHPlcIwh\GWjdHi= MmDXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{OUezNFAoRjJ2Mkm3N|AxRC:jPh?=
ACHN-5968 NYf6ZW5QSXCxcITvd4l{KEG|c3H5 NYKwTIxqPW2P M1n2N|Np M1G4d4VvcGGwY3XzJJBi[2yrdHH4[YwudWWmaXH0[YQh[XCxcITvd4l{yqB? NVrUVHhmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzNFU3ODRpPkK0N|A2PjB2PD;hQi=>
Huh7 MXXBdI9xfG:|aYOgRZN{[Xl? MnjINo1O M2nHUFEzcA>? MVvEUXNQ NFjWSpRqdmirYnn0d{BCYkR6MEW1MYlv\HWlZXSgZ4VtdCCmZXH0bC=> MoHlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{OUezNFAoRjJ2Mkm3N|AxRC:jPh?=
UOK257 MX\BdI9xfG:|aYOgRZN{[Xl? MoX0OY1O Mn;5N4g> M2DCNIVvcGGwY3XzJJBi[2yrdHH4[YwudWWmaXH0[YQh[XCxcITvd4l{yqB? NHfpVpk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEOwOVYxPCd-MkSzNFU3ODR:L3G+
ECSCs  NXfz[oRJSXCxcITvd4l{KEG|c3H5 M3jOblExdU1? NGnDfXY1cA>? NYq3UVJr\GWlcnXhd4V{KHKjcHHtfYNqdi22cnXheIVlKGGyb4D0c5Nqew>? MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDNzOUGwPUc,OjR|MUmxNFk9N2F-
MCF-7  NXPTO2MzTnWwY4Tpc44hSXO|YYm= MXyxNI1O MnLmNlRp MXjpcohq[mm2czD0bIUh[XW2b4DoZYd6KGmwZIXj[YQh[nliY3jlcY91cGW{YYD5JIRzfWe| M4WwVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{G1OVc5Lz5{NEOxOVU4QDxxYU6=
SGC-7901  MYnBdI9xfG:|aYOgRZN{[Xl? M{[3fVJuVQ>? M3HsflFp NVvHd5l1cW6lcnXhd4V{KEODLUSgbY5lfWOnZDDhdI9xfG:|aYO= M4jjcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{KxN|QxLz5{NEOyNVM1ODxxYU6=
SMMC-7721 MmT1RZBweHSxc3nzJGF{e2G7 NXW1dnM{Om2P MlK0NYg> NGPBOoZqdmO{ZXHz[ZMhS0FvNDDpcoR2[2WmIHHwc5B1d3Orcx?= NEPmdI09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEOyNVM1OCd-MkSzNlE{PDB:L3G+
T24 NGH4cHVCeG:ydH;zbZMhSXO|YYm= NHz4em82dU1? NUPLV5k5OS53aB?= NXvYWJc4eG:2ZX70bYF1\XNiY3Xs[YNwgGmkLXnu[JVk\WRiYYDvdJRwe2m| M1\YNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{S5NVc3Lz5{NEO0PVE4PjxxYU6=
NTUB1 NFT6[3NCeG:ydH;zbZMhSXO|YYm= MVe1cW0> M4HSRlEvPWh? NV3v[ZlTeG:2ZX70bYF1\XNiY3Xs[YNwgGmkLXnu[JVk\WRiYYDvdJRwe2m| MkLGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR|NEmxO|YoRjJ2M{S5NVc3RC:jPh?=
MG-63 NVz1S4FGSXCxcITvd4l{KEG|c3H5 NF:ycmIyOG2P NWLhcmRxOTKq NIrqRpVmdmijbnPld{BFWC2rbnT1Z4VlKGGyb4D0c5Nqew>? MlTSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR|NUizNFEoRjJ2M{W4N|AyRC:jPh?=
MG-63 M2TPS2Fxd3C2b4Ppd{BCe3OjeR?= NHXQUGoxNjVxMX3N MkK1N|Jp MVLlcohidmOnczDzZYxqdm:veXPpck1qdmS3Y3XkJINmdGxiYYDvdJRwe2m| MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN3OEO0Nkc,OjR|NUizOFI9N2F-
MG-63 NXrzb4hvTnWwY4Tpc44hSXO|YYm= MkP4NE42NzGvTR?= NGC3Xm01QGh? NVHPZmpkcW6mdXPld{B{[Wyrbn;tfYNqdi2rbnT1Z4VlKGOnbHygeoli[mmuaYT5JIxwe3N? NFPzd3k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO1PFM1Oid-MkSzOVg{PDJ:L3G+
U2OS  M{\VVGZ2dmO2aX;uJGF{e2G7 M33XRVAvPS9zbV2= MoC0OFhp Ml3vbY5lfWOnczDzZYxqdm:veXPpck1qdmS3Y3XkJINmdGxidnnhZoltcXS7IHzvd5M> Ml\tQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR|NUizOFIoRjJ2M{W4N|QzRC:jPh?=
HGC-27 Ml3vSpVv[3Srb36gRZN{[Xl? NGHqTFEyOG2P NV7TeWxyOWh? NITqSHpqdmirYnn0d{B1cGViY3XscEB3cWGkaXzpeJkhdG:|czDifUBTSURyMEGgc5IhVUtvMkKwOi=> NX7TW5N5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS0NVY{PDlpPkK0OFE3OzR7PD;hQi=>
HCT116  M4S5eWFxd3C2b4Ppd{BCe3OjeR?= M3zue|VuVQ>? M3;JS|I1cA>? MknM[Y5p[W6lZYOgeIhmKGGyb4D0c5NqeyCrbnT1Z4VlKGK7IHHwbYdmdmmw NVLRdolLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2NlY2OjJpPkK0OlI3PTJ{PD;hQi=>
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HepG2 NIDNT|hHfW6ldHnvckBCe3OjeR?= M4nWb|VuVQ>? MlPuOIg> MVPpcoNz\WG|ZYOgTGwhemWuZXHz[S=> MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDdzM{W4O{c,OjR5MUO1PFc9N2F-
A549 MkOzRZBweHSxc3nzJGF{e2G7 NInmVms2dU1? M2nTeFQ5cA>? NIrK[phl\WO{ZXHz[ZMhfGinIIDldoNmdnSjZ3Wgc4Yh[2WubDDk[YF1cCCjbnSg[ZhxemW|c3nvckBt\X[nbIOgc4Yh[2G|cHHz[U0{NCCEZXPsbY4uOSCjbnSgUGM{NUmL NYnuO2poRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3NFY{ODNpPkK0O|A3OzB|PD;hQi=>
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A549  Mn3rRZBweHSxc3nzJGF{e2G7 MoniOY1O NWXpOJZIOmh? MmSySG1UVw>? MYTpcohq[mm2czDCSG1ENWmwZIXj[YQh[XCxcITveIlkKGOnbHyg[IVifGh? Mk\IQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5MU[1OlEoRjJ3N{G2OVYyRC:jPh?=
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HUVECs M13w[WZ2dmO2aX;uJGF{e2G7 MVKxNI1O MmLqNE42cA>? NHrDcphl\WO{ZXHz[ZMhfGinIFHHSU1DW0GrbnT1Z4VlKGG3dH;wbIFogSCuZY\l NVnMWmJnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0Olg2QTJpPkKxOFY5PTl{PD;hQi=>
HepG2 Mo\iRZBweHSxc3nzJGF{e2G7 MXqycW0> Mkm3NYg> MXHlcohidmOnczDyZYRq[XSrb36tbY5lfWOnZDDj[YxtKGSnYYTo NIjWPFQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUS1N|Y6OSd-MkG0OVM3QTF:L3G+
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A673 NV7Td2pzeUiWUzDhd5NigQ>? MoDEdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKEF4N{OgZ4VtdHN? MlzZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
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Saos-2 MkfVdWhVWyCjc4PhfS=> M3H5SZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCVYX;zMVIh[2WubIO= M{XHeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
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