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LY294002

目录号：S1105 别名: SF 1101, NSC 697286

仅限科研使用

LY294002 (SF 1101, NSC 697286) 是首个合成的已知抑制PI3Kα/δ/β的小分子，在无细胞测定中IC50分别为 0.5 μM/0.57 μM/0.97 μM；在溶液中比在Wortmannin中稳定，也能够阻断自噬体的形成。它不仅能够结合class I PI3Ks和其他PI3K相关的激酶，还能够结合一些与PI3K家族无关的新型靶点。LY294002 可以抑制CK2，对应的IC50值为98 nM。LY294002 是一种非特异的 DNA-PKcs 抑制剂，并可激活自噬和凋亡。

CAS: 154447-36-6

规格	价格	库存
10mM (1mL in DMSO)	RMB 1570.11	现货
10mg	RMB 1188.16	现货
25mg	RMB 2196.01	现货
200mg	RMB 6298.74	现货
大包装	有超大折扣
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客户使用Selleck生产的LY294002发表文献1473篇：

产品安全说明书

PI3K抑制剂选择性比较

生物活性

产品描述

特性

LY294002是选择性的, 可渗透细胞的特定PI3K抑制剂，可作用于酶的ATP结合位点，且抑制自体吞噬的螯合作用。

靶点

CK2 ^[5] (Cell-free assay)	p110α ^[1] (Cell-free assay)	p110δ ^[1] (Cell-free assay)	p110β ^[1] (Cell-free assay)	DNA-PK ^[6] (Cell-free)
98 nM	0.5 μM	0.57 μM	0.97 μM	1.4 μM

体外研究

LY294002是一种非特异性抑制剂，除了class I PI3Ks，它同样还能抑制其他类型PI3Ks、mTOR、DNA-PK以及其他蛋白激酶，如CK2和Pim-1^[5]。LY294002使Akt/PKB失活,因此抑制细胞增殖和诱导细胞凋亡。 LY294002作用于结肠癌细胞系，使磷酸化Akt (Ser473)的表达下降，明显抑制生长和诱导凋亡。^[2] LY294002作用于肿瘤细胞，诱导明显的核固缩和减少细胞质体积。因此，在体外，LY294002明显抑制卵巢癌细胞增殖。LY294002诱导细胞停在G1期，导致几乎全部的黑色素瘤细胞增殖被抑制，部分MG-63 (骨肉瘤细胞系)增殖被抑制。LY294002作用于细胞周期的效果可用于研究PI3K激活通路和癌细胞周期之间关系。^[3]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Sf9 cells	M{LaOWZ2dmO2aX;uJIF{e2G7			MV7Jcohq[mm2aX;uJI9nKEircz30ZYdo\WRiYn;2bY5mKFCLM1ug[ZhxemW\|c3XkJIlvKFOoOTDj[YxteyxiSVO1NF0yOCEQvF2u	M4ra[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyOUm4N\|UyLz5zMEm5PFM2OTxxYU6=
HeLa cells	MlnmRolv\GmwZzDh[oZqdmm2eTDhd5NigQ>?			NEHTcZVDcW6maX7nJIFn\mmwaYT5JIZweiCSSUOtb4lv[XOnIHnzc4xifGWmIH\yc40hUGWOYTDj[YxteyxiS3m9OkDPxE1?	NEjUdYQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNU[1PFg4OCd-MUW2OVg5PzB:L3G+
HeLa cells	MVLGeY5kfGmxbjDhd5NigQ>?			M4Cx[WlvcGmkaYTpc44hd2ZibWTPVkBxem:2ZXnuJIl{d2yjdHXkJIZzd21iSHXMZUBk\WyuczygTWM2OD1{LkWg{txONg>?	NHLwSG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNU[1PFg4OCd-MUW2OVg5PzB:L3G+
HeLa (human carcinoma) cells.	M{G4NWZ2dmO2aX;uJIF{e2G7			NE[1b5FKdiC4aYTyc{BqdmirYnn0bY9vKG:oIFTORU1l\XCnbnTlcpQheHKxdHXpckBscW6jc3WoSG5CNVCNKTDmdo9uKEinTHGgLIh2dWGwIHPhdoNqdm:vYTmgZ4VtdHNuIFnDOVA:OS52IN88UU4>	M{fR[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NkW4PFcxLz5zNU[1PFg4ODxxYU6=
human PC3 cells	MVnQdo9tcW[ncnH0bY9vKGG\|c3H5	NU\Mc2VsOjVizszN	MX6xNlAhcA>?	Mk\nRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCSQ{OgZ4VtdHNiYYSgNlUhfU1iYX\0[ZIhOTJyIHjyd{BjgSCPVGSgZZN{[XlicnXsZZRqfmVidH:gSG1UVw>?	M4PHXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NkiwNVU6Lz5zNk[4NFE2QTxxYU6=
human BJ cells	M3nQcGZ2dmO2aX;uJIF{e2G7	M3v3U\|I2KM7:TR?=	M3Tj[FIhcA>?	MlvaRYN1cX[jdHnvckBw\iCDa4SgdIhwe3Cqb4L5cIF1cW:wIHH0JHRpejNyODDpckBRTEeILYP0bY12dGG2ZXSgd4VzfW1ic4ThdpZm\CCqdX3hckBDUiClZXzsd{BifCB{NTD1UUB1emWjdHXkJFIhcHK\|IHLl[o9z\SCSRFfGJINp[WyuZX7n[UBjgSCrbX31co9jdG:2dHnu[y=>	MoPsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ5NkewPFUoRjF4N{[3NFg2RC:jPh?=
human BJ cells	M3\r[WZ2dmO2aX;uJIF{e2G7	NWrXTIo6OjVizszN	NIPJN2ozKGh?	NWDpc4l5UW6qaXLpeIlwdiCxZjDQTVNMKHOrZ37hcIlv\yCrbjDQSGdHNXO2aX31cIF1\WRic3XyeY0he3Sjco\l[EBpfW2jbjDCTkBk\WyuczD0doFve2[nY4Tl[EB4cXSqIIDsZZNucWRiRVfGVE9RUCCmb33hbY4hd2ZiQXv0JIF{e2W\|c3XkJIF{KHO3cIDy[ZN{cW:wIH;mJHBJNUWJRmCgdoVlcXO2cnnieZRqd25idH:gdIxie22jIH3lcYJz[W6nIHH0JFI2KHWPIITy[YF1\WRiMjDodpMh[mWob4LlJHBFT0ZiY3jhcIxmdmenIHL5JINwdm[xY3HsJI1q[3Kxc3PvdJk>	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjd4N{C4OUc,OTZ5NkewPFU9N2F-
mouse mast cells	MXzGeY5kfGmxbjDhd5NigQ>?	NHmxRo8zOCEQvF2=		Mn\zTY5pcWKrdHnvckBw\iCVQ1[tbY5lfWOnZDDQT2IwSWu2IIDoc5NxcG:{eXzheIlwdiCrbjDtc5V{\SCvYYP0JINmdGy\|IHH0JFIxKM7:TR?=	MoTWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ5OEm3OFIoRjF4N{i5O\|QzRC:jPh?=
THP1 cells	NHz6PHZHfW6ldHnvckBie3OjeR?=			NGTvVZlKdmirYnn0bY9vKG:oIF3DVFEucW6mdXPl[EBkcGWvb4ThfIl{KG:oIGTIVFEh[2WubIOsJGlEPTB;M{eg{txONg>?	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjd6OUe0Nkc,OTZ5OEm3OFI9N2F-
mouse Raw264 macrophage	NFXQTVNHfW6ldHnvckBie3OjeR?=			M{H6emlvcGmkaYTpc44hd2ZiQ{XhMY1m\GmjdHXkJHBMSi:Da4SgdIhwe3Cqb4L5cIF1cW:wIHnuJI1wfXOnIGLhe\|I3PCCvYXPyc5Bp[WenLDDJR\|UxRTFyIN88UU4>	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjd6OUe0Nkc,OTZ5OEm3OFI9N2F-
THP1 cells	MXjGeY5kfGmxbjDhd5NigQ>?			Ml\VTY5pcWKrdHnvckBw\iCPQ2CxMYlv\HWlZXSgVGtDN0GtdDDwbI9{eGixconsZZRqd25iaX6gWGhROSClZXzsd{whUUN3ME2xMlY2KM7:TT6=	MnW2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ5OEm3OFIoRjF4N{i5O\|QzRC:jPh?=
THP1 cells	NFjodmFHfW6ldHnvckBie3OjeR?=			M1HkZ2lvcGmkaYTpc44hd2ZiU1PGNU1qdmS3Y3XkJHBMSi:Da4SgdIhwe3Cqb4L5cIF1cW:wIHnuJHRJWDFiY3XscJMtKEmFNUC9NU4xOSEQvF2u	MmLTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ5OEm3OFIoRjF4N{i5O\|QzRC:jPh?=
human A375 cells	M4m4eHBzd2yrZnXyZZRqd25iYYPzZZk>		M{PqdFQ3KGh?	M2nPOWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUO3OUBk\WyuczDh[pRmeiB2NjDodpMtKEmFNUC9PE41KM7:TT6=	M{HxSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MES5NlQ5Lz5zN{C0PVI1QDxxYU6=
HeLa cells	M3XmN2Z2dmO2aX;uJIF{e2G7			NFr3[YdKdmirYnn0bY9vKG:oIFHYMVc2ODNiYnnu[Ilv\yC2bzDy[YNwdWKrbnHueEBRdGt\|IHX4dJJme3OnZDDpckBJ\UyjIHPlcIx{KGK7IGfld5Rmem5iYnzveEwhUUN3PUOg{txONg>?	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF\|NUK0PEc,OTdzM{WyOFg9N2F-
human SW480 cells	NEC0ZpJHfW6ldHnvckBie3OjeR?=	MXWyNEDPxE1?	NVewVYlvOjRiaB?=	MWLE[YNz\WG\|ZTDpckB{fXK4aY\pckBmgHC{ZYPzbY9vKGmwIHj1cYFvKFOZNEiwJINmdGy\|IHH0JFIxKHWPIHHmeIVzKDJ2IHjyd{BjgSCrbX31co9jdG:2IHHuZYx6e2m\|	NWThWnFGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0O\|I6PjJpPkG3OFczQTZ{PD;hQi=>
human A375 cells	MWnQdo9tcW[ncnH0bY9vKGG\|c3H5			MWDJcohq[mm2aX;uJI9nKHOncoXtMYlv\HWlZXSgdJJwdGmoZYLheIlwdiCxZjDoeY1idiCDM{e1JINmdGy\|LDDJR\|UxRThwNDFOwG0v	NYXnSVhpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2NFE4OzlpPkG3OlAyPzN7PD;hQi=>
human A2780 cells	NIrFXJRCeG:ydH;zbZMh[XO\|YYm=	MYqyJO69VQ>?	NV;GT2tXOTJiaB?=	MoHCTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDjbZNxdGG2aX6tdoV{cXO2YX70JIh2dWGwIFGyO\|gxKGOnbHzzJIF{e2W\|c3XkJIF{KGSnY4LlZZNmKGmwIIDoc5NxcG:{eXzheIVlKEGtdDDs[ZZmdCCjdDCyJJVOKGGodHXyJFEzKGi{czDifUBqdW23bn;icI91KGGwYXz5d4l{Ng>?	NWraPHZSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2PFQxOThpPkG3Olg1ODF6PD;hQi=>
human H4 cells	MV7GeY5kfGmxbjDhd5NigQ>?		MoLKNkBp	MoL0SIVkemWjc3WgbY4hTlmYRT3SSnAsKH[nc3njcIUhcW62ZX7zbZR6KHCncjDj[YxtKGmwIHj1cYFvKEh2IHPlcIx{KGGodHXyJFIhcHK\|IILlcIF1cX[nIITvJINwdnS{b3y=	MmjPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOThyMkS1PFQoRjF6MEK0OVg1RC:jPh?=
Sf9 cells	M4naUWZ2dmO2aX;uJIF{e2G7			MorPTY5pcWKrdHnvckBw\iCFS{Kg[ZhxemW\|c3XkJIlvKFOoOTDj[YxteyxiSVO1NF03NjlizszNMi=>	MkXJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh\|MkG3NVYoRjF6M{KxO\|E3RC:jPh?=
rat RBL2H3 cells	NIP2V3NHfW6ldHnvckBie3OjeR?=			NWHkSVZsUW6qaXLpeIlwdiCxZjDBNlMyQDdvaX7keYNm\CCmZXfyZY52dGG2aX;uJIlvKHKjdDDSRmwzUDNiY3XscJM>	Mn3lQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh\|Mki3NVYoRjF6M{K4O\|E3RC:jPh?=
human U87MG cells	Mli0SpVv[3Srb36gZZN{[Xl?			NVLHSZRqUW6qaXLpeIlwdiCxZjDHV2s{NWKndHGgbY4hcHWvYX6gWVg4VUdiY3XscJMh[nliRVzJV2EtKEmFNUC9PE4yKM7:TT6=	MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDN2NU[wPUc,OTh\|NEW2NFk9N2F-
human H460 cells	MkPDSpVv[3Srb36gZZN{[Xl?	NFf0NVE{OCEQvF2=		Ml7OTY5pcWKrdHnvckBw\iCSSUPLJIlvKGi3bXHuJGg1PjBiY3XscJMh[XO\|ZYPz[YQh[XNiQXv0JJBpd3OyaH;yfYxifGmxbjDheEBU\XJiNEezJJVxKHSxIEOwJJVO	NH;pZoo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEWwNVYxOSd-MUi1NFE3ODF:L3G+
human U251HRE cells	NWXtZohQTnWwY4Tpc44h[XO\|YYm=			NEHvWG9KdmirYnn0bY9vKG:oIHj5dI95cWFvaX7keYNm\CCKSV[xJIFkfGm4YYTpc44hcW5iaIXtZY4hXTJ3MVjSSUBk\WyuczDifUBk\WyuIHLhd4VlKHKncH;yeIVzKGenbnWgZZN{[Xl?	NILGdGk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEWwNVYxOSd-MUi1NFE3ODF:L3G+
human 184B5 cells	MYPDfZRwfG:6aXRCpIF{e2G7			NHz0T5pEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckAyQDSENTDj[YxteyCkeTDTVmIh[XO\|YYmsJGdKPTB;M{muN\|ch\|ryPLh?=	MlO4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh4OUG4PVQoRjF6NkmxPFk1RC:jPh?=
human MDA-MB-468 cells	NHH2SWNEgXSxdH;4bYPDqGG\|c3H5			NG\CR5lEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtOFY5KGOnbHzzJIJ6KFOUQjDhd5NigSxiSVO1NF0yOC52IN88UU4>	MkDaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh4OUG4PVQoRjF6NkmxPFk1RC:jPh?=
human MDA-MB-468 cells	NF7lO3FEgXSxdH;4bYPDqGG\|c3H5			M3z1fmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj20Olgh[2WubIOgbY4heHKnc3XuZ4Uhd2ZiMUCgeW0h[2iub4LvdZVqdmViYomgV3JDKGG\|c3H5MEBIUTVyPUiuNkDPxE1w	NInYblA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOE[5NVg6PCd-MUi2PVE5QTR:L3G+
MDA-MB-231 cells	Mm\NR5l1d3SxeHnjxsBie3OjeR?=			M1K5RWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN\|Eh[2WubIOgZpkhW1KEIHHzd4F6NCCJSUWwQVYvPzFizszNMi=>	M2HvZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NkmxPFk1Lz5zOE[5NVg6PDxxYU6=
human MDA-MB-468 cells	MXnDfZRwfG:6aXRCpIF{e2G7			NHr4WGdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtOFY5KGOnbHzzJIlvKHC{ZYPlcoNmKG:oIEKwJJVOKGOqbH;yc5F2cW6nIHL5JHNTSiCjc4Phfg+9lCCLQ{WwQVQvPzZizszNMi=>	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDZ7MUi5OEc,OTh4OUG4PVQ9N2F-
human MDA-MB-231 cells	MYTDfZRwfG:6aXRCpIF{e2G7			MYDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy\|IHnuJJBz\XOnbnPlJI9nKDFyIIXNJINpdG:{b4H1bY5mKGK7IGPSRkBie3OjeTygS2k2OD12LkO1JO69VS5?	Mm\OQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh4OUG4PVQoRjF6NkmxPFk1RC:jPh?=
human MDA-MB-231 cells	M1O2U2N6fG:2b4jpZ:Kh[XO\|YYm=			NYPYNJNqS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVI{OSClZXzsd{BqdiCycnXz[Y5k\SCxZjCyNEDPxE1iY3jsc5JweXWrbnWgZpkhW1KEIHHzd4F6NCCJSU2zMlMzKM7:TT6=	NGrjSG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOE[5NVg6PCd-MUi2PVE5QTR:L3G+
human MCF7 cells	NETOWnJEgXSxdH;4bYPDqGG\|c3H5			M3TLZmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[nliU2LCJIF{e2G7LDDHTV0{NjF4IN88UU4>	Ml;LQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh4OUG4PVQoRjF6NkmxPFk1RC:jPh?=
human MCF7 cells	NHnKdIREgXSxdH;4bYPDqGG\|c3H5			Mk\OR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{BqdiCycnXz[Y5k\SCxZjCxNEB2VSClaHzvdo9yfWmwZTDifUBUWkJiYYPzZZktKEeLNUC9N{4xQCEQvF2u	NHTMbWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOE[5NVg6PCd-MUi2PVE5QTR:L3G+
human MCF7 cells	MorpR5l1d3SxeHnjxsBie3OjeR?=			NUWyOXVMS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCrbjDwdoV{\W6lZTDv[kAzOCEQvF2gZ4htd3KxcYXpcoUh[nliU2LCJIF{e2G7LDDHTVUxRTJwNkOg{txONg>?	NVHWVmVvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi2PVE5QTRpPkG4OlkyQDl2PD;hQi=>
Sf21 cells	MmHiSpVv[3Srb36gZZN{[Xl?			NFvXdWlKdmirYnn0bY9vKG:oIH3veZNmKHKnY3;tZolv[W62IGDJN2tidHCqYTDlfJBz\XO\|ZXSgbY4h[mGldXzveolzfXNvaX7m[YN1\WRiU3[yNUBk\WyuczygTWM2OD1yLkWg{txONg>?	NIDUT2o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUe0PFI3QSd-MUm3OFgzPjl:L3G+
Sf9 cells	M2ixcoZtfW:{ZYPj[Y51KHCxbHHybZpifGmxbjDhd5NigQ>?			MX;Jcohq[mm2aX;uJI9nKGi3bXHuJHBKO0upYX3tZUBmgHC{ZYPz[YQhcW5iU3[5JINmdGy\|IHL5JIZtfW:{ZYPj[Y51KHCxbHHybZpifGmxbjDhd5NigQ>?	NX;VWFVzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGxNlE3OzFpPkKxNVIyPjNzPD;hQi=>
Sf9 cells	NXKzfGpoTmy3b4Lld4NmdnRicH;sZZJqgmG2aX;uJIF{e2G7			NFPRTo1KdmirYnn0bY9vKG:oIHj1cYFvKFCLM1vhcJBp[SCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzJIJ6KG[udX;y[ZNk\W62IIDvcIFzcXqjdHnvckBie3OjeTygTWM2OD1yLkW1JO69VS5?	MoPTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFzMkG2N\|EoRjJzMUKxOlMyRC:jPh?=
human IGROV1 cells	NYfMSoJ[TnWwY4Tpc44h[XO\|YYm=		NGO1SmUzPCCq	NI\VS2JE\WyuIHP5Z4xmKGG{cnXzeEBqdiCqdX3hckBKT1KRVkGgZ4VtdHNiYYPz[ZN{\WRiYYOgZYNkfW23bHH0bY9vKGG2IFexJJBp[XOnIHH0JFUh\m:uZDDJR\|UxKGGodHXyJFI1KGi{czDifUBndG:5IHP5eI9u\XS{eR?=	M3\5[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMkG2NVUyLz5{MUKxOlE2OTxxYU6=
human IGROV1 cells	Ml7LSpVv[3Srb36gZZN{[Xl?		MYmyOEBp	M4iwbmNmdGxiY4njcIUh[XK{ZYP0JIlvKGi3bXHuJGlIWk:YMTDj[YxteyCjc4Pld5Nm\CCjczDhZ4N2dXWuYYTpc44h[XRiR{GgdIhie2ViYYSgNUBnd2ymIFnDOVAh[W[2ZYKgNlQhcHK\|IHL5JIZtd3diY4n0c41mfHK7	NX3VUVNbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGyNVYyPTFpPkKxNlE3OTVzPD;hQi=>
human IGROV1 cells	MVPGeY5kfGmxbjDhd5NigQ>?		NGHZSmozPC92ODDo	M2fjb2lvcGmkaYTpc44hd2ZiUFmzT{9Cc3RiaX6gbJVu[W5iSVfSU3YyKGOnbHzzJIF{e2W\|c3XkJIF{KGSnY4LlZZNmKGmwIHP5Z4xqdiCGMTDs[ZZmdCCjdDCxJJRwKDVidHnt[ZMhUUN3MDDh[pRmeiB{NDD0c{A1QCCqcoOgZpkhX2W\|dHXyckBjdG:2IHHuZYx6e2m\|	MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTJzNkG1NUc,OjF{MU[xOVE9N2F-
human IGROV1 cells	Mo\FSpVv[3Srb36gZZN{[Xl?		NHq0[2MzPC92ODDo	MVjJcohq[mm2aX;uJI9nKFCLM1uvRYt1KGmwIHj1cYFvKEmJUl;WNUBk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiCyaH;zdIhwenmuYYTl[EBCU1RibHX2[Ywh[XRiMTD0c{A2KHSrbXXzJGlEPTBiYX\0[ZIhOjRidH:gOFghcHK\|IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>?	MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTJzNkG1NUc,OjF{MU[xOVE9N2F-
human HCT116 cells	M2T5[2N6fG:2b4jpZ:Kh[XO\|YYm=		NUXYXFFoPzJiaB?=	NEXUdoFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJS1RzMU[gZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF02Pi5yMTFOwG0v	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl2NUK1NEc,OjF7NEWyOVA9N2F-
human KB cells	MWTDfZRwfG:6aXRCpIF{e2G7		NFXXe5I4OiCq	NF3iTWlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMSiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG\|c3H5MEBKSzVyPUS0Mlc3KM7:TT6=	MkLQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NEWyOVAoRjJzOUS1NlUxRC:jPh?=
HUVEC	MnjySpVv[3Srb36gZZN{[Xl?	MYKxNE0zPSEQvF2=	M{nQR\|MxKG2rbh?=	MXnJcohq[mm2aX;uJI9nKFSQRnHsdIhiNXO2aX31cIF1\WRiaIXtZY4hUUODTT2xJJBzd22xdHXyJIFkfGm4aYT5JIV5eHKnc4Pl[EBqdiCKVW\FR{Bie3Onc4Pl[EBieyCkZYThMYdidGGldH;zbYRie2ViYXP0bZZqfHliYYSgNVAhfG9iMkWgeW0heHKndILlZZRm\CCob4KgN\|AhdWmwczDi[YZwemViVF7GZYxxcGFiY3jhcIxmdmenIH3lZZN2emWmIHHmeIVzKDViaILzJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeR?=	MoT6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyMk[0NVAoRjJ{MEK2OFExRC:jPh?=
HUVEC	MWDGeY5kfGmxbjDhd5NigQ>?	M2XqdFExNTJ3IN88US=>	MljPNVYhcA>?	NIPGfW5KdmirYnn0bY9vKG:oIGTOSoFteGijLYP0bY12dGG2ZXSgTWNCVS1zIH3SUmEh\XiycnXzd4lwdiCrbjDIWXZGSyCjdDCxNEB1dyB{NTD1UUBxemW2cnXheIVlKG[xcjCxOkBpenNiYnXmc5JmKFSQRnHsdIhiKGOqYXzs[Y5o\SCvZXHzeZJm\CCjZoTldkA3KGi{czDifUBTXC2SQ2KgZY5idHm\|aYO=	M3;pclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MEK2OFExLz5{MkCyOlQyODxxYU6=
human HCT116 cells	MkPPSpVv[3Srb36gZZN{[Xl?	NH3NOYkyOCEQvF2=		NFrHcVdKdmirYnn0bY9vKG:oIFHreEBmgHC{ZYPzbY9vKGmwIHj1cYFvKEiFVEGxOkBk\WyuczDheEAyOCC3TTDifUBqdW23bn;icI91KGGwYXz5d4l{	MoXCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{MUK3NlEoRjJ{MkGyO\|IyRC:jPh?=
human HCT116 cells	MmnNSpVv[3Srb36gZZN{[Xl?	NIHxdWUyOCEQvF2=		MUTJcohq[mm2aX;uJI9nKFCLM1vhcJBp[SCKMUC0O3IhdXW2YX70JIlvKGi3bXHuJGhEXDFzNjDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEGtdDDT[ZI1PzNicHjvd5Bpd3K7bHH0bY9vKGG2IEGwJJVOKGK7IHntcZVvd2Kub4SgZY5idHm\|aYO=	NW\oU2hHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyNVI4OjFpPkKyNlEzPzJzPD;hQi=>
human HCT116 cells	NFG5colHfW6ldHnvckBie3OjeR?=	M13rZlExKM7:TR?=		NIDjd2NKdmirYnn0bY9vKG:oIGDJN2tidHCqYTDpckBpfW2jbjDIR3QyOTZiY3XscJMh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBCc3RiU3XyOFc{KHCqb4PwbI9zgWyjdHnvckBifCBzMDD1UUBjgSCrbX31co9jdG:2IHHuZYx6e2m\|	M1vJblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MkGyO\|IyLz5{MkKxNlczOTxxYU6=
human HCT116 cells	NFvyOphHfW6ldHnvckBie3OjeR?=	MmrXNVAh\|ryP	M2jSUFExKG2rbh?=	MXfJcohq[mm2aX;uJI9nKFCLM1vhcJBp[SCKMUC0O3IhdXW2YX70JIlvKGi3bXHuJGhEXDFzNjDj[YxteyC3c3nu[{BcOzKSXVHUVEBifCBzMDD1UUBi\nSncjCxNEBucW6\|	M{XxT\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MkGyO\|IyLz5{MkKxNlczOTxxYU6=
human HCT116 cells	MnS4SpVv[3Srb36gZZN{[Xl?	NWDxS2pjOTBizszN	M4r3XVExKG2rbh?=	M3PEfmlvcGmkaYTpc44hd2ZiUFmzT4FteGijIHnuJIh2dWGwIFjDWFEyPiClZXzsd{B2e2mwZzDbN\|JRZUGWUDDheEAyOCC3TTDh[pRmeiBzMDDtbY5{	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJzMkeyNUc,OjJ{MUK3NlE9N2F-
human HCT116 cells	NXvsc5ppT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		NYXt[ohxPDhiaB?=	NITSRXRIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBJS1RzMU[gZ4VtdHNib4\ldoV5eHKnc4PpcochWEl\|S3HsdIhiKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUC9Ok44KM7:TT6=	M4rQZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MkGyO\|IyLz5{MkKxNlczOTxxYU6=
human HCT116 cells	MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		NHL0UHU1QCCq	NFLnR2tIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBJS1RzMU[gZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF02NjhizszNMi=>	NGDaVo49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkKxNlczOSd-MkKyNVI4OjF:L3G+
human HCT116 cells	NV\FcJR{T3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		NYq2PXV1PDhiaB?=	M1rLWGdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGhEXDFzNjDj[YxteyCxdnXy[ZhxemW\|c3nu[{BRUTONYXzwbIEhUDFyNEfSJI12fGGwdDDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTVwMzFOwG0>	NXjMOZBHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyNVI4OjFpPkKyNlEzPzJzPD;hQi=>
human A549 cells	MVfDfZRwfG:6aXRCpIF{e2G7		Mle0O\|IhcA>?	Mn3mR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG\|c3H5	MnHBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2OEC4OVEoRjJ{NEiwPFUyRC:jPh?=
human PC3 cells	NWjmem1iS3m2b4TvfIlkyqCjc4PhfS=>		NF;KRW84OiCq	M4HPNWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBEOyClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG\|c3H5MEBKSzVyPU[xMlM2KM7:TT6=	Mo\nQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2OEC4OVEoRjJ{NEiwPFUyRC:jPh?=
human HL60 cells	NUfjdHRzS3m2b4TvfIlkyqCjc4PhfS=>		MWK3NkBp	NX;FdoFyS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEx4MDDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVkvQTRizszNMi=>	NYrN[FJ[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0PFA5PTFpPkKyOFgxQDVzPD;hQi=>
Sf21 cells	MmD1SpVv[3Srb36gZZN{[Xl?			MVzJcohq[mm2aX;uJI9nKG2xdYPlJJdqdGRidInw[UBRUTONYXzwbIEh\XiycnXzd4VlKGmwIGPmNlEh[2WubIOgZ48u\XiycnXzd4lv\yCQLYTldo1qdmGuIFjpd{11[WepZXSgbJVu[W5icEi1ZUB2e2mwZzDMMYFteGijLYDoc5NxcGG2aXT5cIlvd3OrdH;sJJN2[nO2cnH0[UBjgSCWTFOgZoF{\WRicHjvd5Bpd3JiaX3h[4lv\yxiSVO1NF0xNjVizszN	NUPWUFRIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK1NlA3OzBpPkKyOVIxPjNyPD;hQi=>
HEK293 cells	NUmyUlBZTnWwY4Tpc44h[XO\|YYm=		MVOxMlUhcA>?	M{fqeWRqe3CuYXPlcYVvfCCxZjDbN2heVFOGIH\yc40hcHWvYX6gOWhVPiC{ZXPldJRweiCneIDy[ZN{\WRiaX6gTGVMOjl\|IHPlcIx{KGGodHXyJFEvPSCqcoOgZpkhdGmzdXnkJJNkcW62aXzsZZRqd25iY3;1cpRqdmd?	NGe1e2k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkWzO\|E2Oyd-MkK1N\|cyPTN:L3G+
human H1299 cells	NHL0VXlHfW6ldHnvckBie3OjeR?=	Mo\6NE4yNTNyIN88US=>	NY\3bIxOOjRiaB?=	NHnCWoxKdmS3Y4Tpc44hd2ZiSl7LMY1m\GmjdHXkJGNJV1BiZYjwdoV{e2mxbjDpckBpfW2jbjDINVI6QSClZXzsd{BifCByLkGgeI8hOzBidV2gZYZ1\XJiMkSgbJJ{KGK7IGfld5Rmem5iYnzveEBidmGueYPpdy=>	NV3WRpZnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK2NlIxPjlpPkKyOlIzODZ7PD;hQi=>
human H1299 cells	M4DL[mZ2dmO2aX;uJIF{e2G7	M13WNFAvOS1\|MDFOwG0>	NYPpe2piOjRiaB?=	NIGwb\|FKdmS3Y4Tpc44hd2ZiRGK1JIV5eHKnc4Ppc44hcW5iaIXtZY4hUDF{OUmgZ4VtdHNiYYSgNE4yKHSxIEOwJJVOKGGodHXyJFI1KGi{czDifUBY\XO2ZYLuJIJtd3RiYX7hcJl{cXN?	NEDhOpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mk[yNlA3QSd-MkK2NlIxPjl:L3G+
human H1299 cells	NEe5c2lHfW6ldHnvckBie3OjeR?=	MYmwMlEuOzBizszN	NVrGb41{OjRiaB?=	NUK1NG8zTG:5bjDy[Yd2dGG2aX;uJI9nKGOLQWCyJIV5eHKnc4Ppc44hcW5iaIXtZY4hUDF{OUmgZ4VtdHNiYYSgNE4yKHSxIEOwJJVOKGGodHXyJFI1KGi{czDifUBY\XO2ZYLuJIJtd3RiYX7hcJl{cXNiaX6gdJJme2WwY3Wgc4YhOTByIIXnM41tKFSUQVnMJIFv\CCSSUPLJIlvcGmkaYTvdkBNYTJ7NECwNi=>	NX7hfms6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK2NlIxPjlpPkKyOlIzODZ7PD;hQi=>
human H1299 cells	M4XNXGZ2dmO2aX;uJIF{e2G7	MVmwMlEuOzBizszN	MoXxNlQhcA>?	MlzkSI94diC{ZXf1cIF1cW:wIH;mJINKSVB{IHX4dJJme3Orb36gbY4hcHWvYX6gTFEzQTliY3XscJMh[XRiMD6xJJRwKDNyIIXNJIFnfGW{IEK0JIhzeyCkeTDX[ZN1\XKwIHLsc5Qh[W6jbInzbZM>	NWXySGszRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK2NlIxPjlpPkKyOlIzODZ7PD;hQi=>
MDA-MB-231 cells	NWXyeWNlS2WubDDpcpZie2mxbjDhd5NigQ>?		NGr1fGUzPCCq	Mn3HTY5pcWKrdHnvckBw\iCncHn0bIVtcWGuIHfyc5d1cCCoYXP0c5IucW6mdXPl[EBk\WyuIH3p[5JifGmxbjDv[kBpfW2jbjDNSGEuVUJvMkOxJINmdGy\|IIDy[U1qdmO3YnH0[YQh\m:{IEK0JIhzeyCkeTDj[YxtKGmwdnHzbY9vKGG\|c3H5MEBKSzVyPUCuN\|gh\|ryPLh?=	NIXmcYQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkiwOFExQCd-MkK4NFQyODh:L3G+
human LNCAP cells	MV3GeY5kfGmxbjDhd5NigQ>?	NFzIRZQxNjFvM{Cg{txO	NEPJfYYzPCCq	M{nnXmRwf26{ZXf1cIF1cW:wIH;mJJN2en[rdnnuJIV5eHKnc4Ppc44hcW5iaIXtZY4hVE6FQWCgZ4VtdHNiYYSgNE4yKHSxIEOwJJVOKGGodHXyJFI1KGi{czDifUBY\XO2ZYLuJIJtd3RiYX7hcJl{cXN?	MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh\|MkOxOkc,OjJ6M{KzNVY9N2F-
human LNCAP cells	MYrGeY5kfGmxbjDhd5NigQ>?	NH\YTVkxNjFvM{Cg{txO	M1nzVFMxKG2rbh?=	NIHJeo1KdmirYnn0bY9vKG:oIFHreEBxcG:\|cHjvdplt[XSrb36gbY4hcHWvYX6gUG5ESVBiY3XscJMh[XRiMD6xJJRwKDNyIIXNJIFnfGW{IEOwJI1qdnNiYomgW4V{fGW{bjDicI91KGGwYXz5d4l{	M1i5[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OEOyN\|E3Lz5{MkizNlMyPjxxYU6=
human PC3 cells	MmW0SpVv[3Srb36gZZN{[Xl?	MVm1NEDPxE1?	NILtb4s5KGh?	M3HXRWlv\HWldHnvckBw\iCyMkGgdJJwfGWrbjDlfJBz\XO\|aX;uJIlvKGi3bXHuJHBEOyClZXzsd{BifCB3MDD1UUBqdmO3YnH0[YQh\m:{IEigbJJ{KGK7IGfld5Rmem5iYnzveJRqdmdicnXsZZRqfmVidH:geY51emWjdHXkJINwdnS{b3y=	M2HT[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OUm4OFczLz5{Mkm5PFQ4OjxxYU6=
human BT474 cell	NGDLU3JRem:uaX\ldoF1cW:wIHHzd4F6		MYe3NkBp	NXTrOoQ{UW6qaXLpeIlwdiCxZjDoeY1idiCEVES3OEBk\WyuIIDyc4xq\mW{YYTpc44h[W[2ZYKgO\|IhcHK\|IHL5JJNx\WO2cn;wbI91d22ndILpZ{BidmGueYPpd-+9lCCLQ{WwQVIxNjdizszNMi=>	NUTmTZd{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0NVAxODVpPkKzOFExODB3PD;hQi=>
human PC3 cell	MlrKVJJwdGmoZYLheIlwdiCjc4PhfS=>		M3\rV\|czKGh?	MojlTY5pcWKrdHnvckBw\iCqdX3hckBRSzNiY3XscEBxem:uaX\ldoF1cW:wIHHmeIVzKDd{IHjyd{BjgSC\|cHXjeJJweGixdH;t[ZRzcWNiYX7hcJl{cXNuIFnDOVA:OTJwMTFOwG0v	NYm1R4RURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0NVAxODVpPkKzOFExODB3PD;hQi=>
human PC3 cells	MmfCSpVv[3Srb36gZZN{[Xl?		MljTN\|AhdWmw	NXrIdZp2UW6qaXLpeIlwdiCxZjDQTVNMKGmwIHj1cYFvKFCFMzDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG\|ZTDpckBCU1RicHjvd5Bpd3K7bHH0bY9vKGG2IIPldolv\SB2N{OgZYZ1\XJiM{CgcYlveyCkeTDFUGlUSSxiSVO1NF0yNjQQvF2u	NIrm[2E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{SxNFAxPSd-MkO0NVAxODV:L3G+
human MGC803 cells	M4TNS2Z2dmO2aX;uJIF{e2G7	NF6wO4QzPSEQvF2=	MmnyOFghcA>?	NGrH[XNE\WyuIHP5Z4xmKGG{cnXzeEBqdiCqdX3hckBOT0N6MEOgZ4VtdHNiYYPz[ZN{\WRiYYOgZYNkfW23bHH0bY9vKGG2IFeyM20heGijc3WgZZQhOjVidV2gZYZ1\XJiNEigbJJ{KHW\|aX7nJJBzd3CrZHn1cUBqd2SrZHWgd5RicW6rbnegZYZ1\XJiNEigbJJ{KGK7IH\sc5ch[3m2b33leIVzKHKnbHH0bZZmKHSxIHPvcpRzd2x?	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDFzOUi2PUc,OjRzMUm4Olk9N2F-
mouse RAW264.7 cells	M2\lemZ2dmO2aX;uJIF{e2G7	NXqyTnRvOjVizszN	MkHPNlAhcA>?	NYTUcXpNUW6qaXLpeIlwdiCxZjDQTVNMN0GNVDDpckBud3W\|ZTDSRXczPjRwNzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEySUz3pcoR2[2WmIHnOU3MheHKxdHXpckBmgHC{ZYPzbY9vKGG2IEK1JO69VSCjZoTldkAzOCCqcoOgZpkhX2W\|dHXyckBjdG:2IHHuZYx6e2m\|	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDJ7OU[xOkc,OjR{OUm2NVY9N2F-
human A549 cells	MXrQdo9tcW[ncnH0bY9vKGG\|c3H5		NEHVWpU4OiCq	NVrKR4JGSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W\|c3XkJIF{KGmwaHnibZRqd25ib3[gZYJ{d3KkYX7j[UBi\nSncjC3NkBpenNiYomgUXRVKGG\|c3H5MEBKSzVyPUiyMlMzKM7:TT6=	MljIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4OUO3PFcoRjJ3NkmzO\|g4RC:jPh?=
human HuH7 cells	NV7wWVJsWHKxbHnm[ZJifGmxbjDhd5NigQ>?		M3;VTFczKGh?	NIjYdmRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFj1TFch[2WubIOgZZN{\XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjDhZpNwemKjbnPlJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTB;NkeuNVgh\|ryPLh?=	NFK4fJc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[5N\|c5Pyd-MkW2PVM4QDd:L3G+
human HCT116 cells	NEjDcFZRem:uaX\ldoF1cW:wIHHzd4F6		MlTDO\|IhcA>?	M{Dxe2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFPUNVE3KGOnbHzzJIF{e2W\|c3XkJIF{KGmwaHnibZRqd25ib3[gZYJ{d3KkYX7j[UBi\nSncjC3NkBpenNiYomgUXRVKGG\|c3H5MEBKSzVyPUWxMlgzKM7:TT6=	NWnoflR[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2PVM4QDdpPkK1Olk{Pzh5PD;hQi=>
human HL60 cells	M1\Q[HBzd2yrZnXyZZRqd25iYYPzZZk>		NXf6XVUyPzJiaB?=	NF[2UolCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjMOlAh[2WubIOgZZN{\XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjDhZpNwemKjbnPlJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTB;MUiuOFMh\|ryPLh?=	M3X5blxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkmzO\|g4Lz5{NU[5N\|c5PzxxYU6=
Sf9 cells	MUHGeY5kfGmxbjDhd5NigQ>?			M{\vVGlvcGmkaYTpc44hd2ZiSHnzMZRi\2enZDDoeY1idiCFS{Kg[ZhxemW\|c3XkJIlvKFOoOTDj[YxteyxiSVO1NEA:KDZwOTFOwG0v	NVzKTmY4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC5PVg{PTFpPkGwPVk5OzVzPD;hQi=>
HeLa cells	NXr4WoxHTnWwY4Tpc44h[XO\|YYm=			NF30PIhKdiC4aYTyc{BqdmirYnn0bY9vKG:oIFTORU1l\XCnbnTlcpQheHKxdHXpckBscW6jc3WoSG5CNVCNKTDmdo9uKEinTHGgLIh2dWGwIHPhdoNqdm:vYTmgZ4VtdHNwLDDJR\|UxKD1iMT60JO69VS5?	M4\nR\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{OUSxN\|M6Lz5zMkm0NVM{QTxxYU6=
HeLa cells	NGLGTXdHfW6ldHnvckBie3OjeR?=			MljyTY5pcWKrdHnvckBw\iCGTlGg[IVx\W6mZX70JJBzd3SnaX6gb4lv[XOnIHnzc4xifGWmIH\yc40hUGWOYTDj[YxteyxiSVO1NEA:KDFwNTFOwG0v	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTZ3OEi3NEc,OTV4NUi4O\|A9N2F-
Sf21 cells	MmHnSpVv[3Srb36gZZN{[Xl?			M3WyVmlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiUFmzT4JmfGFiZYjwdoV{e2WmIHnuJIJi[3Wub4\pdpV{NWmwZnXjeIVlKFOoMkGgZ4VtdHNuIFnDOVAhRSByLkmg{txONg>?	MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTd2OEK2PUc,OTl5NEiyOlk9N2F-
Sf21 cells	NUCwfm5lTnWwY4Tpc44h[XO\|YYm=			NHjjOYpKdmirYnn0bY9vKG:oIHLveolv\SC{ZXPvcYJqdmGwdDDQTVNM\2GvbXGg[ZhxemW\|c3XkJIlvKGKjY4Xsc5ZqenW\|LXnu[oVkfGWmIGPmNlEh[2WubIOsJGlEPTBiPTC3JO69VS5?	NWrVUFl{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm3OFgzPjlpPkG5O\|Q5OjZ7PD;hQi=>
HeLa cells	NHX4TVRHfW6ldHnvckBie3OjeR?=			Mo[yRYN1cX[rdImgZZQhWEl\|SzDpckBpfW2jbjDI[WxiKGOnbHzzJIJ6KEWOSWPBMEBGSzVyIE2gNU42KM7:TT6=	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODB7MkOyN{c,OjByOUKzNlM9N2F-
Sf21 cells	MVLGeY5kfGmxbjDhd5NigQ>?			NUPXU5RiUW6qaXLpeIlwdiCxZjDQTVNM\GWudHGg[ZhxemW\|c3XkJIlvKGOnbHzzJINwNWW6cILld5NqdmdiTj30[ZJucW6jbDDIbZMufGGpZ3XkJIh2dWGwIIC4OYEhfXOrbnegUE1idHCqYT3wbI9{eGijdHnkfYxqdm:\|aYTvcEB{fWK\|dILheIUh[nliVFzDJIJie2WmIIDoc5NxcG:{IHntZYdqdmduIFnDOVAhRSByLkW3JO69VS5?	NXnWeWtNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK1NlA3OzBpPkKyOVIxPjNyPD;hQi=>
Sf21 cells	M1S0NmZ2dmO2aX;uJIF{e2G7			NWjaV4xbUW6qaXLpeIlwdiCxZjDoeY1idiC5aXzkJJR6eGViUFmzT4JmfGFiZYjwdoV{e2WmIHnuJHNnOjFiY3XscJMh[29vZYjwdoV{e2mwZzDOMZRmem2rbnHsJGhqey22YXfn[YQhcHWvYX6gdFg2[SC3c3nu[{BNNWGucHjhMZBpd3OyaHH0bYR6dGmwb4PpeI9tKHO3YoP0doF1\SCkeTDUUGMh[mG\|ZXSgdIhwe3Cqb4KgbY1i\2mwZzygTWM2OCB;IECuPVch\|ryPLh?=	NFfzd\|Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkWyNFY{OCd-MkK1NlA3OzB:L3G+
HL60 cells	NVHlV\|FVSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MU[zJIRigXN?	NILV[XFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjMOlAh[2WubIOgcYVie3W{ZXSgZYZ1\XJiMzDkZZl{KGK7IF3UV{Bie3OjeTygTWM2OCB;IEG0JO69VS5?	M{LQW\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OUS1NVExLz5{Nkm0OVEyODxxYU6=
U937 cells	M2S5dWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NH3uVGg{KGSjeYO=	NXv2TW86SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDVPVM4KGOnbHzzJI1m[XO3cnXkJIFnfGW{IEOg[IF6eyCkeTDNWHMh[XO\|YYmsJGlEPTBiPTCxOEDPxE1w	NEnnN249[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nkm0OVEyOCd-Mk[5OFUyOTB:L3G+
Jurkat cells	M1\JeWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MX[zJIRigXN?	NIDFOY5CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFr1dotifCClZXzsd{Bu\WG\|dYLl[EBi\nSncjCzJIRigXNiYomgUXRUKGG\|c3H5MEBKSzVyIE2gNlIh\|ryPLh?=	MkPiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ7NEWxNVAoRjJ4OUS1NVExRC:jPh?=
K562 cells	Mn;mRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MV[zJIRigXN?	NFmycYxCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFu1OlIh[2WubIOgcYVie3W{ZXSgZYZ1\XJiMzDkZZl{KGK7IF3UV{Bie3OjeTygTWM2OCB;IEO4JO69VS5?	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjl2NUGxNEc,OjZ7NEWxNVA9N2F-
U266 cells	MofWRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MYOzJIRigXN?	MXTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFV{Nk[gZ4VtdHNibXXhd5Vz\WRiYX\0[ZIhOyCmYYnzJIJ6KE2WUzDhd5NigSxiSVO1NEA:KDR4IN88UU4>	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjl2NUGxNEc,OjZ7NEWxNVA9N2F-
MDA-MB-231 cells	MmXTRY51cW2rZ4LheI9zgSCjc4PhfS=>		Ml\4NlQhcHK\|	MkDhRY51cW2rZ4LheI9zgSCjY4Tpeol1gSCjZ3HpcpN1KEWJRjDpcoR2[2WmIHPo[Y1wfGG6aYOgbY4hcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDwdoVqdmO3YnH0[YQh\m:{IEK0JIhzeyCob3zsc5dm\CCkeTDFS2Yh[WSmaYTpc44h\m:{IEOuOUBpenNiYomgcIlocHRibXnjdo9{[2:yeTygTWM2OCB;IECuN\|gh\|ryPLh?=	NEfPbVk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{W5PFI{Pyd-Mke1PVgzOzd:L3G+
MDA-MB-231 cells	NFjESGZCdnSraX72ZZNqfmViYYPzZZk>		M1jrTFMvPSCqcoO=	NV;hSo1MSW62aXnueoF{cX[nIHHjeIl3cXS7IHnuJIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCHR1[tbY5lfWOnZDDj[YxtKGmwdnHzbY9vKGGodHXyJFMvPSCqcoOsJGlEPTBiPTCwMlM5KM7:TT6=	M4WxRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEC5OVIyLz5{OECwPVUzOTxxYU6=
HEK293T cells	NWfvVY1UTnWwY4Tpc44h[XO\|YYm=		Ml;XNUBpeg>?	MUfJcohq[mm2aX;uJI9nKGmvbX;ibYxqgmWmIF6tUHkzQTRyMEKgZoVi\CCkaX7kbY5oKHSxIGDJN2tj\XSjIDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJGhGUzJ7M2SgZ4VtdHNiaX7jeYJifGWmIH\vdkAyKGi{IHL5JGxENU2VL13TJIFv[Wy7c3nzMEBKSzVyIE2gNE41OiEQvF2u	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJ6MEK2NUc,Ojh{OECyOlE9N2F-
HEK293T cells	M{S2W2Z2dmO2aX;uJIF{e2G7		Mnv5NUBpeg>?	MnvyTY5pcWKrdHnvckBw\iCrbX3vZoltcXqnZDDOMWx[Ojl2MECyJIJm[WRiYnnu[Ilv\yC2bzDQTVNM\GWudHGgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO\|ZXSgbY4hUEWNMkmzWEBk\WyuczDpcoN2[mG2ZXSg[o9zKDFiaIKgZpkhVENvTWOvUXMh[W6jbInzbZMtKEmFNUCgQUAyNjV\|IN88UU4>	NI\rfYU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEK4NFI3OSd-MkiyPFAzPjF:L3G+
HEK293T cells	NFLRS5dHfW6ldHnvckBie3OjeR?=		MUexJIhz	Mo\RTY5pcWKrdHnvckBw\iCrbX3vZoltcXqnZDDOMWx[Ojl2MECyJIJm[WRiYnnu[Ilv\yC2bzDQTVNM[WyyaHGgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO\|ZXSgbY4hUEWNMkmzWEBk\WyuczDpcoN2[mG2ZXSg[o9zKDFiaIKgZpkhVENvTWOvUXMh[W6jbInzbZMtKEmFNUCgQUAzNjN5IN88UU4>	NGGwPFg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEK4NFI3OSd-MkiyPFAzPjF:L3G+
MDA-MB-231 cells	NFm0VmlHfW6ldHnvckBie3OjeR?=			M{TVWGlvcGmkaYTpc44hd2ZiRVfGMYlv\HWlZXSgbY53[XOrb36gc4YhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjN6IN88UU4>	NUXkO41CRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkizNFI1ODFpPkK4N\|AzPDBzPD;hQi=>
MCF7 cells	NETTcFNHfW6ldHnvckBie3OjeR?=	NIS5dIwyOCC3TR?=	M2X1S\|EhcHJ?	NIfKZ5dKdmirYnn0bY9vKG:oIFnHSlFTKHCqb4PwbI9zgWyjdHnvckBifCCWeYKxNVYyKHKnc3nkeYUhcW5iaIXtZY4hVUOINzDj[YxteyCjdDCxNEB2VSCjZoTldkAyKGi{IHL5JGhw\WOqc4SgN\|MzPThic4ThbY5qdmdiYnHz[YQhcW2vdX7vbIl{fG:laHXtbYNidCCjbnHsfZNqew>?	M{X1c\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NUW3OFMxLz5{OEW1O\|Q{ODxxYU6=
SKOV3 cells	NGj5ZmJHfW6ldHnvckBie3OjeR?=	MX[yNEB2VQ>?	MVGyOEBpenN?	NHj2PWpKdmirYnn0bY9vKG:oIFLEUmYucW6mdXPl[EBqdn[jc3nvckBqdiCqdX3hckBUU0:YMzDj[YxteyCjdDCyNEB2VSCjZoTldkAzPCCqcoOgbY4h[nlibXH0dolo\WxiaX72ZZNqd25iYYPzZZk>	Mo\0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlzMkK0PFQoRjJ7MUKyOFg1RC:jPh?=
SKOV3 cells	NFnmZVZCdnSrbXnndoF1d3K7IHHzd4F6	MorHNlAhfU1?	MWmyOEBpenN?	MonaRY51cW2rZ4LheI9zgSCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJHNMV1Z\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4YhSkSQRj3pcoR2[2WmIHPlcIwhdWmpcnH0bY9vKGG2IEKwJJVOKGGodHXyJFI1KGi{czDifUB{[3KjdHPoJJdwfW6mIHjlZYxqdmdiYYPzZZk>	Mm\TQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlzMkK0PFQoRjJ7MUKyOFg1RC:jPh?=
NB1643 cells	NX3NcJZxeUiWUzDhd5NigQ>?			NYTVVoJ3eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IF7CNVY1OyClZXzsdy=>	M{PUbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
OHS-50 cells	M1P6dJFJXFNiYYPzZZk>			MWPxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhV0iVLUWwJINmdGy\|	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
SJ-GBM2 cells	MnPmdWhVWyCjc4PhfS=>			MWnxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhW0pvR1LNNkBk\Wyucx?=	M1z2clxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SK-N-MC cells	MojadWhVWyCjc4PhfS=>			NVjmOnNDeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IGPLMW4uVUNiY3XscJM>	MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
J774 cells	MoHjRY51cWmwZnzhcY1ifG:{eTDhd5NigQ>?		M4ix[VI1KGi{cx?=	NXHGbnQ{SW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBqdiCvb4Xz[UBLPzd2IHPlcIx{KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDpckBNWFNvaX7keYNm\CCPQ2CxJIV5eHKnc4Ppc44h[W[2ZYKgNlQhcHK\|IHL5JGVNUVODLDDJR\|UxKD1iMz63JO69VS5?	NYC3PIxZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm3NlY3QDBpPkK5O\|I3PjhyPD;hQi=>
J774 cells	NWHzNId{SW62aXnu[oxidW2jdH;yfUBie3OjeR?=		MUOyOEBpenN?	M{f5O2FvfGmrbn\sZY1u[XSxcomgZYN1cX[rdImgbY4hdW:3c3WgTlc4PCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gUHBUNWmwZIXj[YQhUUx4IHX4dJJme3Orb36gZYZ1\XJiMkSgbJJ{KGK7IFXMTXNCNCCLQ{WwJF0hPS5zIN88UU4>	MorWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl5Mk[2PFAoRjJ7N{K2OlgxRC:jPh?=
J774 cells	MlvvRY51cWmwZnzhcY1ifG:{eTDhd5NigQ>?		MUKyOEBpenN?	M{nodWFvfGmrbn\sZY1u[XSxcomgZYN1cX[rdImgbY4hdW:3c3WgTlc4PCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gUHBUNWmwZIXj[YQhdmm2cnnjJI95cWSnIIDyc4R2[3Srb36gZYZ1\XJiMkSgbJJ{KGK7IFfybYV{eyCjc4PhfUwhUUN3MDC9JFgvQSEQvF2u	Mk\LQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl5Mk[2PFAoRjJ7N{K2OlgxRC:jPh?=
J774 cells	Mn;JSpVv[3Srb36gZZN{[Xl?	M1THbFExKHWP	NV7PbndDPCCqcoO=	NUnTUmNMUW6qaXLpeIlwdiCxZjDQTVNMN0GtdDDpckBud3W\|ZTDKO\|c1KGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDMVHMucW6mdXPl[EBCc3RicHjvd5Bpd3K7bHH0bY9vKGG2IGPldlQ4OyCjdDCxNEB2VSCjZoTldkA1KGi{czDifUBY\XO2ZYLuJIJtd3RiYX7hcJl{cXN?	M1rEU\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7N{K2OlgxLz5{OUeyOlY5ODxxYU6=

Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID

Western blot	E-cadherin / p-Akt / Akt beta-catenin / p-GSK3β / Cyclin D1 Bcl-xl / Bax / caspase3 / cleaved caspase-3 p-p70S6K (T389) / p-GSK3β(S9) / pERK / Vinculin pPKB-S473	29731993 25344912 23251002 20649566
Growth inhibition assay	Cell viability	25344912
Immunofluorescence	α-SMA / CD31 E-cadherin / beta-catenin COX-2 / p-NFκB FOXO3a	27671604 29731993 18388194
ELISA	IL-10 / IL-1β / TNFα / IL-6	22208359

体内研究

体内，LY294002也抑制肿瘤生长和诱导凋亡，尤其作用于LoVo肿瘤, 因此作用于鼠癌性腹膜炎模型具有明显药效。^[2] LY294002明显抑制卵巢癌生长和腹水形成。^[3]

激酶实验： ^[4]	激酶实验: 使用重组酶和1 μM ATP，通过辐射实验测定LY294002对PI3K的抑制效果。室温下(24^oC)进行激酶反应1小时，然后加入PBS终止反应。通过剂量反应曲线测定IC50值。通过激酶选择性筛选来抑制CK2和GSK3β。加入10 μM ATP，测定LY294002作用于一组激酶的效果。
细胞实验： ^[2]	Cell lines: 结肠癌细胞系： DLD-1, LoVo, HCT15, 和Colo205 Concentrations: 0-50 μM Incubation Time: 0-48小时 Method: 1×10⁵个细胞(每孔100 μL)接种在96孔板上。设三个复孔，加入LY294002，在37^oC下培养0-48小时。处理后, 10 μL Premix WST-1 加到每孔中,然后在37^oC下温育60分钟,然后用微型计数板在450nm处测定吸光值。
动物实验： ^[3]	Animal Models: 腹腔注射OVCAR-3细胞的无胸腺裸鼠(5-7周大) Dosages: 0-100 mg/kg Administration: 每天腹腔注射，持续3周

参考文献	[1] Chaussade C, et al. Biochem J, 2007, 404(3), 449-58. [2] Semba S, et al. Clin Cancer Res, 2002, 8(6), 1957-63. [3] Hu L, et al. Clin Cancer Res, 2000, 6(3), 880-6. [4] Gharbi SI, et al. Biochem J, 2007, 404(1), 15-21. [5] Severine I. Gharbi, et al. Biochem J. 2007, 404(3):449-58. [6] David Davidson, et al. Front Pharmacol. 2013, 4: 5. + 展开

溶解度（25°C）

体外


体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： 5% DMSO+ 40%PEG 300+5% Tween 80+50%ddH2O 点击购买： PEG300 Tween 80	3mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量	307.34
化学式	C₁₉H₁₇NO₃
CAS号	154447-36-6
储存条件	3年	-20°C	粉状
储存条件	2年	-80°C	溶于溶剂

Download LY294002 SDF

动物体内配方计算器（澄清溶液）

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 μL 动物数量只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO + % + % Tween 80 + % ddH2O

%DMSO+ %

计算结果：

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于μL DMSO溶液（母液浓度mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取μL DMSO母液，加入μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入μL ddH₂O，混匀澄清。

体内配方配制方法：取μL DMSO母液，加入μL Corn oil，混匀澄清。

注意：1. 首先保证母液是澄清的；
2.一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×

稀释计算器分子量计算器

临床试验信息

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT02337309	Terminated	Drug: SF1126	Neuroblastoma	New Approaches to Neuroblastoma Therapy Consortium\|SignalRX Pharmaceuticals Inc.\|University of Southern California	July 9 2015	Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

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常见问题及建议解决方法

问题 1:
I want to buy a inhibitor that can inactivates Akt/PI3K. I notice the protocol of LY294002 (catalog no. s1105) says it will inactivates Akt/PKB. Is LY294002 available for Akt/PI3K inhibition?

回答：
LY294002 is the first synthetic molecule known to inhibit PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM, respectively. It can inhibit PI3K/AKT. PKB is the alternative name of AKT.

问题 2:
What is the suggested formulation of this compound for mouse injection(i.p.)?

回答：
It can be dissolved in 4% DMSO/30% PEG 300/5% Tween 80/ddH2O at 5 mg/ml clearly, and the concentration of DMSO is safe for in vivo experiments.

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