Idelalisib (CAL-101, GS-1101)

目录号:S2226

Idelalisib (CAL-101, GS-1101) Chemical Structure

Molecular Weight(MW): 415.42

Idelalisib (CAL-101, GS-1101) 是选择性p110δ抑制剂,在无细胞试验中IC50为 2.5 nM;对 p110δ 表现出的选择性是对 p110α/β/γ 的 40 到 300 倍,对p110δ的选择性是对 C2β,hVPS34,DNA-PK 和 mTOR的400到4000倍。

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RMB 1279.19 现货
RMB 972.85 现货
RMB 3867.24 现货
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客户使用Selleck该产品发表文献38篇:

客户使用该产品的6个实验数据:

  • Invasive migration of RA FLS was analyzed through growth factor–reduced Matrigel-coated transwell inserts in the presence or absence of 1 µM INK007, 5 µM CAL-101, or 0.3 µM IPI-145, or 0.3 µM GDC-0941 inhibitors or DMSO. Cells were allowed to invade through Matrigel toward PDGF-BB (25 ng/ml) containing media for 24 h and were fixed and stained with Hemacolor staining kit.

    J Immunol, 2014, 192(5): 2063-70 . Idelalisib (CAL-101, GS-1101) purchased from Selleck.

    Ppp2r1afl/fl BCR-ABL1 B-ALL cells transduced with 4-OHT-inducible Cre-ERT2 (Cre) or ERT2-vector (EV) were treated with 4-OHT for 3 days and cell lysates were studied by phospho-protein array analysis. Ppp2r1afl/fl BCR-ABL1 ALL cells were transduced with 4-OHT-inducible Cre or EV control and incubated in the presence of the small molecule signaling inhibitor idelalisib (32 μmol/L; C). Percentages of GFP+ cells were measured by flow cytometry at the times indicated following 4-OHT-treatment. Data are shown as mean ± standard deviation (SD) and representative of at least three independent experiments.

    Cell, 2018, 173(2):470-484. Idelalisib (CAL-101, GS-1101) purchased from Selleck.

  • Rolling and sticking fractions of calcein-labeled CLL cells from a patient with bulky disease are shown before treatment, and at 3 or 7 weeks under idelalisib treatment. Mean ± SD, venular order III (n = 3), order IV (n = 4), order V (n = 3-4). Unpaired t test; *P < .05, **P < .01.

    Blood, 2016, 127(25):3192-201. Idelalisib (CAL-101, GS-1101) purchased from Selleck.

    293T cells were transfected with HA-tagged Fbxo45. At 48 h after transfection, cells were treated with AKT inhibitor (CAL-101; 10 uM, 4 h), cell extracts from the cytoplasm or nuclei were subjected to IP with anti-HA resin followed by western blot analysis with indicated antibodies.

    Cell Death Differ 2014 21(10), 1535-45. Idelalisib (CAL-101, GS-1101) purchased from Selleck.

  • Isoform-selective PI3K inhibitors blocked PI3K signaling in corresponding Rh30-Myr-p110 cells. Rh30-Myr-p110s cells were cultured in serum-free medium for 12 h, and then exposed to CAL-101 at indicated concentrations for additional 1 h. The cells were collected to detect the level of phosphorylated and total Akt. β-Actin was served as loading control.

    Acta Pharmacol Sin 2013 34(9),1201-7. Idelalisib (CAL-101, GS-1101) purchased from Selleck.

    After starved in serum-free medium for 24 h,A549 cells incubated with the indicated concentrations of CAL-101 for 3 h,followed by 20-minute stimolation of 100ng/ml EGF.

    Dr. Zhang of Tianjin Medical University. Idelalisib (CAL-101, GS-1101) purchased from Selleck.

产品安全说明书

PI3K抑制剂选择性比较

生物活性

产品描述 Idelalisib (CAL-101, GS-1101) 是选择性p110δ抑制剂,在无细胞试验中IC50为 2.5 nM;对 p110δ 表现出的选择性是对 p110α/β/γ 的 40 到 300 倍,对p110δ的选择性是对 C2β,hVPS34,DNA-PK 和 mTOR的400到4000倍。
特性 Calistoga 暗示 CAL-101治疗血液恶性肿瘤可能有更广泛的应用价值。
靶点
p110δ [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
2.5 nM 89 nM
体外研究

CAL-101 对p110α, p110β,和p110γ作用效果不大。CAL-101作用于原代嗜碱细胞特定阻断FcϵR1 p110δ调节的 CD63表达,EC50 为8 nM。与急性髓性白血病(AML) 和骨髓增生性肿瘤(MPN) 细胞相比,CAL-101 作用于B-cell急性淋巴细胞白血病(B-ALL)和慢性淋巴细胞白血病(CLL) 细胞时显示更强的活性。CAL-101 作用于SU-DHL-5, KARPAS-422 和CCRF-SB细胞,降低pAktS473, pAktT308, 和下游靶点S6, EC50为0.1到1.0 μM。 [1] CAL-101 作用于CLL细胞,诱导选择性细胞毒性,不是通过突变状态或间期细胞遗传学,主要通过caspase依赖机制。与正常B细胞相比,CAL-101作用于CLL 细胞优先产生细胞毒性,和LY294002相比,作用于其他造血细胞不会产生毒性。CAL-101 作用于T 细胞和天然杀伤细胞 缺乏直接的细胞毒性潜能。CAL-101抑制炎症细胞因子的产生,比如 IL-6, IL-10, TNF-α,和IFN-γ,且激活诱导的细胞因子,如CD40L。CAL-101 也抗CD40L调节的CLL细胞存活。[2] CAL-101 作用于L1236和L591细胞, 诱导细胞在G1期积累,在S期下降,说明 CAL-101可以作为治疗霍杰金淋巴瘤(HL)的一种新策略。[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MEC1 NXnkVG9NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIf1eGNFVVOR NXvpNFl3UUN3ME2yNE41KM7:TR?= NHXuVYkzPTl7OUO1Ni=>
CLL PBMCs M2rCeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\ZSG1UVw>? MkTxTWM2OD1{Lkmgcm0> NXTVNmJMOjV7MUeyOlc>
U266 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXDVY81OCEQvF2= NUPnOZpsPDhiaB?= NFjKWZY4QS53JTDpcohq[mm2aX;uJJJifGV? M3vwOFI2OzN7M{Oy
K562 MWfGeY5kfGmxbjDBd5NigQ>? NIDybZUyKM7:TR?= MYWzJIg> MkS3TY5pcWKrdHnvckBw\iCDa4SgdIhwe3Cqb4L5cIF1cW:w MkjGNlUxOTR5N{W=
K562 M3PiNWZ2dmO2aX;uJGF{e2G7 MV2xJO69VQ>? M1zGdVMhcA>? M1TrfmlvcGmkaYTpc44hd2ZiUEewV|ZMKHCqb4PwbI9zgWyjdHnvci=> M1zROVI2ODF2N{e1
K562 NFTiT5hHfW6ldHnvckBCe3OjeR?= MWOxJO69VQ>? NX;VXnJVOyCq MYDJcohq[mm2aX;uJI9nKEeVS{OgdIhwe3Cqb4L5cIF1cW:w NWjSZodLOjVyMUS3O|U>
K562 M{PHZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{Lse|Eh|ryP M2Xl[VczKGh? MXPJcohq[mm2aX;uJI9nKHC{b3zp[oVz[XSrb36= NHTyUJYzPTBzNEe3OS=>
Primary AML cell MoezSpVv[3Srb36gRZN{[Xl? NFvUXlkyKM7:TR?= MWqzJIg> NUHnTW82UW6qaXLpeIlwdiCxZjDBb5QheGixc4Doc5J6dGG2aX;u NFjHTG0zPTBzNEe3OS=>
Primary AML cell NYHIVHFUTnWwY4Tpc44hSXO|YYm= NIGzXXoyKM7:TR?= NYLOVI1sOyCq MkW3TY5pcWKrdHnvckBw\iCSN{DTOmsheGixc4Doc5J6dGG2aX;u MofmNlUxOTR5N{W=
Primary AML cell M1jUUGZ2dmO2aX;uJGF{e2G7 M1zkOFEh|ryP MVOzJIg> NVL3dHVuUW6qaXLpeIlwdiCxZjDHV2s{KHCqb4PwbI9zgWyjdHnvci=> NHTwRlAzPTBzNEe3OS=>
Primary AML cell Ml\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWKxJO69VQ>? MknEN{Bp Mmn2V5VxeHKnc4Ppc44hd2ZicmLORUB{gW62aHXzbZM> MYWyOVAyPDd5NR?=
Microglia MXHGeY5kfGmxbjDBd5NigQ>? NVTreXliPSEQvF2= NILFUpEyOCCq NYDBTm94TE2VTx?= NEG3[GFF\WO{ZXHz[UBw\iCWTl\hJJNm[3KndHnvckBnem:vIFzQV{1{fGmvdXzheIVlKCCyMUGw{tRFQTFyQT;EPVExSSCvaXPyc4dtcWF? MUWyOFYzPTZ6NB?=
Primary CLL cell M3vzbmZ2dmO2aX;uJGF{e2G7 NFLnRmwyKM7:TR?= MXKxOUBucW5? NIDNe25FVVOR MVvCcI9kc3NiQlPSMYlv\HWlZXSgUGNROSC|ZYLpcoUuPSCjY4TpeoF1cW:w MYKyOFAxQTJ|Mx?=
JEKO-1 NWjaWXlvTnWwY4Tpc44hSXO|YYm= M4jVfVEh|ryP MofJO|IhcA>? M3;hcmlvcGmkaYTpc44hd2ZiQXv0JJBpd3OyaH;yfYxifGmxbjDpckBK\01vc4TpcZVt[XSnZDDKSWtQNTF? MoTkNlM{PDF3NEG=
Granta-519 MVXGeY5kfGmxbjDBd5NigQ>? M1n4dFEh|ryP NWm3cWhVOiCq MVnJcohq[mm2aX;uJI9nKEGtdDj0N|A5MSCyaH;zdIhwenmuYYTpc44> MkfINlM{PDF3NEG=
Granta-519 MlvKSpVv[3Srb36gRZN{[Xl? NUj5blM{OSEQvF2= M3XTRVIhcA>? NVfr[2tKUW6qaXLpeIlwdiCxZjDBb5QpezR5MzmgdIhwe3Cqb4L5cIF1cW:w MnHJNlM{PDF3NEG=
JEKO-1 MoH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWWxNEDPxE1? MWG3NkBp MYTJcohq[mm2aX;uJI9nKHC{b3zp[oVz[XSrb36gd4xq\2i2bIm= NWfU[HMzOjN|NEG1OFE>
JEKO-1 NF;s[ZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUS1JO69VQ>? M3i1eVczKGh? Mlvl[I9meyCwb4SgbY5lfWOnIHPlcIwh[3mlbHWgZZJz\XO2IH;yJIFxd3C2b4Ppdy=> NF65cpIzOzZ5NkKyNC=>
MAVER-1 NWfwTHJ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;PT3ljPSEQvF2= NVj2fmk{PzJiaB?= MnT4[I9meyCwb4SgbY5lfWOnIHPlcIwh[3mlbHWgZZJz\XO2IH;yJIFxd3C2b4Ppdy=> NIT3VWszOzZ5NkKyNC=>
MINO M3nC[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETj[JE2KM7:TR?= M2fTNlczKGh? NFvzeYpld2W|IH7veEBqdmS3Y3WgZ4VtdCCleXPs[UBienKnc4Sgc5Ih[XCxcITvd4l{ NVuyWmY1OjN4N{[yNlA>
SP53 M4jTdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETMNJYxNjFizszN NFrkbWU4OiCq NY[yN2tD\G:nczDuc5QhcW6mdXPlJINmdGxiY4njcIUh[XK{ZYP0JI9zKGGyb4D0c5Nqew>? NWjQenV5OjN4N{[yNlA>
HH NWDOcWlDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHDRVIyOCEQvF2= MlKzO|IhcA>? M4DYfWROW09? MnS5TY5lfWO2aX;uJI9nKGGyb4D0c5NqeyC|bHnnbJRtgQ>? NFLBWJczOjhyMUm1PS=>
Myla MkO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHONVAh|ryP NGPSbnk4OiCq NV7TTllsTE2VTx?= NITPbVZld2W|IH7veEBqdmS3Y3WgZZBweHSxc3nz MVuyNlgxOTl3OR?=
SR786 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjkTnJyOTBizszN MkPRO|IhcA>? MWjEUXNQ MojR[I9meyCwb4SgbY5lfWOnIHHwc5B1d3Orcx?= MXKyNlgxOTl3OR?=
HuT78 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVmxNEDPxE1? NXzyU|ZVPzJiaB?= NHuycIxFVVOR NWLPTZFb\G:nczDuc5QhcW6mdXPlJIFxd3C2b4Ppdy=> MoiwNlI5ODF7NUm=
MJ MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17odVExKM7:TR?= M4HNUVczKGh? MoP3SG1UVw>? NHzUTXpld2W|IH7veEBqdmS3Y3WgZZBweHSxc3nz M4TxUVIzQDBzOUW5
DERL7 NYq3RlV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33Zb|ExKM7:TR?= NGDvdZQ4OiCq NXTmR5U{TE2VTx?= NYPSTZIx\G:nczDuc5QhcW6mdXPlJIFxd3C2b4Ppdy=> MWKyNlgxOTl3OR?=
L1236 MWLGeY5kfGmxbjDBd5NigQ>? MXqxNEDPxE1? NHP6T3AzKGh? M{LiNmlvcGmkaYTpc44hd2ZiQXv0JJBpd3OyaH;yfYxifGmxbh?= NV\0SoJ[OjJ{MUC4O|c>
L428 MVLGeY5kfGmxbjDBd5NigQ>? M{HYWVExKM7:TR?= NUfrVm9TOiCq M1;4VmlvcGmkaYTpc44hd2ZiQXv0JJBpd3OyaH;yfYxifGmxbh?= NHnVcZAzOjJzMEi3Oy=>
L591 M{TMS2Z2dmO2aX;uJGF{e2G7 Ml7TNVAh|ryP Mmr2NkBp NUK4VZBUUW6qaXLpeIlwdiCxZjDBb5QheGixc4Doc5J6dGG2aX;u M{fIe|IzOjFyOEe3
KMH-2 MmjuSpVv[3Srb36gRZN{[Xl? M{DudFExKM7:TR?= MoK2NkBp MUfJcohq[mm2aX;uJI9nKEGtdDDwbI9{eGixconsZZRqd25? MmDENlIzOTB6N{e=
L1236 MYTGeY5kfGmxbjDBd5NigQ>? NUDZcoRzPSEQvF2= NFP5SoQzPCCq M1T4ZmJtd2OtczDz[YNz\XSrb36gc4YhfGinIFPDUFU> NWDqU|NIOjJ{MUC4O|c>
L591 MXPGeY5kfGmxbjDBd5NigQ>? NFTqRYw2KM7:TR?= M2\4OVI1KGh? NHLkW3pDdG:la4Ogd4VkemW2aX;uJI9nKHSqZTDDR2w2 M2PMflIzOjFyOEe3
L1236 MnLvRZBweHSxc3nzJGF{e2G7 NHvaXlE2KM7:TR?= NXr3V29rOjRiaB?= Ml7UTY5lfWO2aX;uJI9nKGGyb4D0c5Nqew>? MlfENlIzOTB6N{e=
L591 M3rFOmFxd3C2b4Ppd{BCe3OjeR?= NWjXZnRrPSEQvF2= NVvuWWtrOjRiaB?= Mnm2TY5lfWO2aX;uJI9nKGGyb4D0c5Nqew>? MYSyNlIyODh5Nx?=
U-87MG NXrxRWIzTnWwY4Tpc44hSXO|YYm= MXWxNFAhdk1? NXfRWXExOjRiaB?= MYPEUXNQ M4CweGlvcGmkaYTpc44hd2ZiIHPlcIwhdWmpcnH0bY9v MnHPNlIxPzl4MEm=
SW1783 NIDlZ4FHfW6ldHnvckBCe3OjeR?= NHnYWJoyODBibl2= NH6w[IQzPCCq NIi0c45FVVOR NVLvcIZ{UW6qaXLpeIlwdiCxZjCgZ4VtdCCvaXfyZZRqd25? NX[zW2dOOjJyN{m2NFk>
U-87MG NYj6fnZyTnWwY4Tpc44hSXO|YYm= MlzhOUDPxE1? NHHZUnMzPCCq MnPPSG1UVw>? M2q5OGlvcGmkaYTpc44hd2ZiQXv0JJBpd3OyaH;yfYxifGmxbjDzeYJ{fGGwdHnhcIx6 MlzTNlIxPzl4MEm=
SW1783 M13Pb2Z2dmO2aX;uJGF{e2G7 NVfoWWlKPSEQvF2= MljtNlQhcA>? M2HE[GROW09? Mkm5TY5pcWKrdHnvckBw\iCDa4SgdIhwe3Cqb4L5cIF1cW:wIIP1ZpN1[W62aXHscJk> M4OzdFIzODd7NkC5
U-373MG MojBSpVv[3Srb36gRZN{[Xl? Mlj4OUDPxE1? NX2z[4c6OjRiaB?= NF7nSWhFVVOR MmnDTY5pcWKrdHnvckBw\iCDa4SgdIhwe3Cqb4L5cIF1cW:wIIP1ZpN1[W62aXHscJk> M1XkWlIzODd7NkC5
SK-MG3 NWjvcYIxTnWwY4Tpc44hSXO|YYm= M2nYPFUh|ryP NVz5T|dIOjRiaB?= NGnVeWRFVVOR MkHrTY5pcWKrdHnvckBw\iCDa4SgdIhwe3Cqb4L5cIF1cW:wIIP1ZpN1[W62aXHscJk> MYCyNlA4QTZyOR?=
SU-DHL-5 NEfXTWZHfW6ldHnvckBCe3OjeR?= NXWycY0xOSEQvF2= NUPIOWhCOjRiaB?= MYPEUXNQ M13HXmlv\HWldHnvckBw\iCjcH;weI9{cXN? NH3Ze3IzODl3OU[wOi=>
WSU-NHL NXLSWI5nTnWwY4Tpc44hSXO|YYm= M1jl[VEh|ryP MXuyOEBp MUHEUXNQ MnLQTY5lfWO2aX;uJI9nKGGyb4D0c5Nqew>? NIDYbWgzODl3OU[wOi=>
CCRF-SB MlXrSpVv[3Srb36gRZN{[Xl? MmDHNUDPxE1? M2S2fFI1KGh? M161TmROW09? NIj1fFZKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m| NYfHNVB6OjB7NUm2NFY>
INA-6 NVfpVnZCTnWwY4Tpc44hSXO|YYm= MkjlOUDPxE1? NGLI[nQ3KGh? M2fzWGlvcGmkaYTpc44hd2ZiUFmzT{9Cc3RiYX7kJGVTUyCyYYToe4F6 NWf1dFBpOjB3MEWxOVg>
LB NGr2d5VHfW6ldHnvckBCe3OjeR?= NV3DRW9wPSEQvF2= M4fOVFYhcA>? NVT0UoE2UW6qaXLpeIlwdiCxZjDQTVRMN0GtdDDhcoQhTVKNIIDheIh4[Xl? MXOyNFUxPTF3OB?=

... Click to View More Cell Line Experimental Data

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[2]
+ 展开

PI3K实验:

用全CLL和正常B细胞溶解物进行PI3K实验。 进行PI3K ELISA 实验。全细胞抽提物加到PI(4,5)P2 底物和反应 buffer(包含 ATP)的混合物中,在室温下温育。加入 PI(3,4,5)P3 探测器和 EDTA混合,反应终止,在室温下温育1小时。混合物转移到PI3K ELISA板上,再温育1小时。 冲洗反应板,然后和第二探测器再温育30分钟。再次冲洗反应板, 加入3,3′,5,5′-四甲基联苯胺溶液 ,反应5分钟,加入H2SO4 终止反应。在450纳米处读数。
细胞实验:[2]
+ 展开
  • Cell lines: CLL B 细胞或健康志愿者的T细胞或NK细胞
  • Concentrations: 0.01-100 μM
  • Incubation Time: 48小时
  • Method: 进行MTT实验测定细胞毒性。1×105个细胞和CAL-101一起温育。加入MTT试剂, 再次温育20小时,然后用溶于PBS的硫酸鱼精蛋白冲洗。加入DMSO, 用分光光度计在540纳米处测定吸光度。使用膜联蛋白/PI液式细胞计检查在不同时间点测定细胞存活力,分析数据。每个样本至少计数104个细胞。以全部阳性细胞与未处理细胞之比百分数的形式来表示实验结果。加入100 μM Z-VAD检测caspase-依赖的细胞凋亡。加入 1 μg/mL CD40L, 800 U/mL IL-4, 50 ng/mL BAFF, 20 ng/mL TNF-α测定存活信号, 或者共培养在纤连蛋白或 HS-5 细胞系基质包被的板上。 基质共培养 在75cm2培养瓶 (80%-100% 融合率) 培养24 小时,然后加入CLL细胞。
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 83 mg/mL warmed (199.79 mM)
Ethanol 23 mg/mL (55.36 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
30% PEG 400 (dissolve first)+0.5% Tween 80+5% Propylene glycol
30mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 415.42
化学式

C22H18FN7O

CAS号 870281-82-6
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03349346 Recruiting Diffuse Large B-Cell Lymphoma|Mediastinal B-cell Lymphoma Gilead Sciences June 2019 Phase 1
NCT03639324 Not yet recruiting Chronic Lymphocytic Leukemia|CLL|Relapsed CLL|Refractory Chronic Lymphocytic Leukemia|Relapsed Chronic Lymphocytic Leukemia Virginia Commonwealth University January 31 2019 Phase 1
NCT03545035 Not yet recruiting Chronic Lymphocytic Leukemia Gruppo Italiano Malattie EMatologiche dell''Adulto|ERIC Group December 2018 --
NCT03582098 Recruiting Chronic Lymphocytic Leukaemia Gilead Sciences September 12 2018 --
NCT03742323 Recruiting Acute Lymphoblastic Leukemia PETHEMA Foundation July 1 2018 Phase 1|Phase 2
NCT03151057 Recruiting B Cells-Tumors|B Cell Chronic Lymphocytic Leukemia|Follicular Lymphoma|Mantle Cell Lymphoma|Large B-Cell Diffuse Lymphoma of Bone (Diagnosis) Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins|Gilead Sciences July 31 2018 Phase 1

技术支持

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操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    What is the recommended dose of CAL-101 and the route of administration for mouse studies?

  • 回答:

    According to the following paper, S2226 can be used by I.V. administration at the concentration of 40 mg/kg. https://www.ncbi.nlm.nih.gov/pubmed/24625684

PI3K Signaling Pathway Map

PI3K Inhibitors with Unique Features

相关PI3K产品

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID