所有产品
| 目录号 | 产品名 | 产品描述 |
|---|---|---|
| S6037 | Methyl p-tert-butylphenylacetate | Methyl 4-tert-butylphenylacetate is a flavouring ingredient with a roasted, chocolate-like flavour. |
| S4714 | (-)-Menthol | (-)-Menthol is a levo isomer of menthol and used as a cooling agent that strongly activates TRPM8. |
| E4118 | (-)-Menthone | (-)-Menthone is a monoterpene component of the essential oil of maturing peppermint. (+)-Neomenthyl-β-d-glucoside is a metabolite of (-)-Menthone. Mortality of two biological forms of Anopheles stephensi (larvae) exposed to about 45 ppm (-)-Menthone is 27.67% and 94.92%. |
| S3088 | (±)-Methyl Jasmonate | (±)-Methyl Jasmonate (MeJA, Methyl jasmonate, Methyl 2-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)acetate), a phytohormone that acts as a vital cell regulator in plants, is a new candidate for the treatment of Inflammatory bowel diseases (IBDs), modulating the expression of the major classes of caspase-type protease families. |
| S7770 | 1-Methoxy PMS | Methoxy-PMS (1-Methoxy PMS), an active oxygen formation inducer, is a stable electron-transport mediator between NAD(P)H and tetrazolium dyes. Methoxy-PMS receives an electron from NADH or NADPH at the membrane or inside of the cell and passes the electron to the WST-8 that is around the outer cell membrane. |
| S6282 | 1-Methyl-2-pyrrolidone | 1-Methyl-2-pyrrolidone (NMP, N-Methylpyrrolidone) is a highly refined solvent and intended for use in biological, proteomics, and other sensitive assays. |
| E0157 | 1-Methyl-3-nitro-1-nitrosoguanidine (MNNG) | 1-Methyl-3-nitro-1-nitrosoguanidine (MNNG) is an orally active alkylating agent with toxic and mutagenic effects. It acts as a carcinogen and mutagen among 3 human diploid lymphoblast lines, MIT-2, WI-L2, and GM 130.The product is a solid-liquid mixture.Solutions are unstable and should be fresh-prepared. |
| S0310 | 1-Methyl-7-nitroisatoic anhydride (1M7) | 1-methyl-7-nitroisatoic anhydride (1M7) is a commonly applied RNA-SHAPE electrophile for probing 2'-hydroxyl reactivity. |
| S3346 | 1-Methylnicotinamide chloride | 1-Methylnicotinamide (1-MNA, 3-Carbamoyl-1-methylpyridin-1-ium, Trigonellamide) chloride is an active endogenous metabolite of nicotinamide that exhibits anti-inflammatory and anti-thrombotic activities. 1-Methylnicotinamide enhances tumor vasculature formation and markedly increases prostacyclin (PGI2) generation. |
| S6216 | 1-Methylpyrrolidine | 1-Methylpyrrolidine is extensively used in the synthesis of pyrrolidine based ionic liquids. |
| E2696 | 11-Mercaptoundecanoic acid | 11-Mercaptoundecanoic acid (MUA) is a thiol-containing fatty acid, which has been described in the preparation of self-assembled monolayers (SAMs), mixed monolayers, and metal-associated nanoparticles. |
| E0184 | 2-Mercaptobenzothiazole | 2-Mercaptobenzothiazole (Benzothiazole-2-thiol, 2-MBT, Mercapto-2-benzothiazole) is an exceptionally potent inhibitor of banana polyphenoloxidase and can significantly delay the onset of substrate oxidation at concentrations as low as 100 nM. |
| S3661 | 2-Methoxy-1,4-naphthoquinone | 2-Methoxy-1,4-naphthoquinone, isolated from the leaves of Impatiens glandulifera, specifically suppressed the expression of PKC βI, δ, and ζ in a concentration-dependent manner in Raji cells. |
| S6295 | 2-Methoxybenzoic acid | 2-Methoxybenzoic acid (o-Anisic acid) is a flavouring agent. |
| S9482 | 2-methoxycinnamaldehyde | 2-methoxycinnamaldehyde (O-methoxycinnamaldehyde), found in ceylan cinnamon, is a flavouring ingredient. |
| S5758 | 2-Methoxycinnamic acid | 2-Methoxycinnamic acid (AI3-11206) is a cinnamic acid with magnetic properties. |
| S1233 | 2-Methoxyestradiol (2-MeOE2) | 2-Methoxyestradiol (2-MeOE2, NSC 659853, 2-ME2) depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. 2-Methoxyestradiol induces both autophagy and apoptosis in various carcinogenic cell lines. |
| S6167 | 2-Methyl-4-pentenoic Acid | 2-Methyl-4-pentenoic acid is a branched-chain fatty acid. |
| S5148 | 2-Methylenebutyrolactone | 2-Methylenebutyrolactone (Tulipalin A, MBL, α-methylene-γ-butyrolactone), also known as α-methylene-γ-butyrolactone (MBL) (Tulipalin A), belongs to the class of sesquiterpene lactone family and is considered as cyclic analog of most common vinyl monomer methyl methacrylate (MMA). |
| S6099 | 2-Methylheptanoic Acid | 2-Methylheptanoic Acid is a flavouring ingredient. |
| S6079 | 2-Methylhexanoic acid | 2-Methylhexanoic acid is a flavouring ingredient. |
| S6307 | 2-Methyllactic acid | 2-Methyllactic acid (2-Hydroxyisobutyric acid, Acetonic acid) is a metabolite of methyl tertiary-butyl ether. |
| S6110 | 2-Methylpentanedioic acid | 2-Methylglutaric acid (alpha-Methylglutaric acid) is a metabolite of succinic acid, a citric acid cycle intermediate. |
| S3314 | 2-Methylpentanoic acid | 2-Methylpentanoic acid (2-Methylvaleric acid, Methylpropylacetic acid) is a short-chain fatty acid that exists in various foods including cheeses, cherimoya, lamb and mutton, and so on. 2-Methylpentanoic acid is a flavor compound used for food-flavor ingredient, fragrances. |
| S6356 | 2-Methylsuccinic acid | 2-Methylsuccinic acid (Pyrotartaric acid, 2-methylbutanedioic acid, propane-1,2-dicarboxylic acid, Methylsuccinate) is a normal metabolite found in human fluids. |
| S6274 | 2-Methyltetrahydrofuran-3-one | 2-Methyltetrahydrofuran-3-one is a volatile constituent of the aroma complex of roasted coffee. |
| S6030 | 3-(3-Methoxyphenyl)propionic acid | 3-(3-Methoxyphenyl)propionic acid is a naturally occurring human metabolite, It is an organic acid and excreted in human urine. |
| S6341 | 3-(Methylthio)propionic acid | 3-(Methylthio)propionic acid (3-methylthiopropionate, 4-Thiapentanoic acid, 3-Methylsulfanylpropionic acid) is a thia fatty acid acid consisting of propionic acid with a methylthio substituent at the 3-position and an intermediate in mammalian methionine metabolism in vitro. |
| S2767 | 3-MA (3-Methyladenine) | 3-MA (3-Methyladenine) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM in HeLa cells; blocks class I PI3K consistently, whereas suppression of class III PI3K is transient, and also blocks autophagosome formation. Solutions are unstable and should be fresh-prepared. |
| S1127 | 3-Maleimidopropionic acid | 3-Maleimidopropionic acid is an alkyl chain-based PROTAC linker that is applicable to the synthesis of PROTACs. |
| S5449 | 3-Methoxybenzamide | 3-Methoxybenzamide (3-MBA) is a competitive inhibitor of poly(ADP-ribose) synthetase with Ki values of less than 2 μM and also inhibits ADP-ribosyltransferase (ADPRT) |
| S6025 | 3-Methoxybenzoic acid | 3-Methoxybenzoic acid (m-Anisic acid, 3-Methoxybenzoate, 3-Anisic acid, m-Methylsalicylic acid) is a food additive that acts as a flavouring ingredient. |
| S3370 | 3-Methoxytyramine hydrochloride | 3-Methoxytyramine (3-O-methyl Dopamine, 3MT) hydrochloride, a major extracellular metabolite of dopamine, is a neuromodulator that in certain situations may be involved in movement control. |
| S3123 | 3-Methyl-2-buten-1-ol | 3-Methyl-2-buten-1-ol (Prenol, Prenyl alcohol, Dimethylallyl alcohol) is an endogenous metabolite. |
| S6148 | 3-Methyl-2-oxobutanoic acid | 3-Methyl-2-oxobutanoic acid (alpha-Ketoisovalerate, alpha-Ketoisovaleric acid), a neurotoxin, an acidogen and a metabotoxin, is an abnormal metabolite that arises from the incomplete breakdown of branched-chain amino acids. |
| S6169 | 3-Methyladipic acid | 3-Methyladipic acid (3-Methyladipate, β-Methyladipic acid, β-Methyladipate) is a metabolite of the catabolism of phytanic acid. |
| S6287 | 3-Methylbutanoic acid | 3-Methylbutanoic acid (Isovaleric acid, Delphinic acid, 3-Methylbutyric acid, Isopentanoic acid, β-methylbutyric acid) is a natural fatty acid found in a wide variety of plants and essential oils. It has a strong pungent cheesy or sweaty smell, but its volatile esters have pleasing scents and are used widely in perfumery. |
| S3347 | 3-Methylglutaric acid | 3-Methylglutaric acid (MGA, 3MG acid) is a conspicuous C6 dicarboxylic organic acid that can be used as a single solid-state NMR standard compound to perform all calibration steps except for magnet shimming. |
| S5146 | 3-Methylpyrazole | 3-Methylpyrazole (3-MP) is a weak or non-inhibitor of alcohol dehydrogenase. |
| S6089 | 3-Methylvaleric acid | 3-Methylvaleric acid is a flavouring ingredient. |
| S6186 | 3-Methylxanthine | 3-Methylxanthine (3-MX), a 3-alkylxanthine, is an inhibitor of cyclic guanosine monophosphate (GMP) phosphodiesterase (PDE) with IC50 of 920 μM on guinea-pig isolated trachealis muscle. |
| S5851 | 4'-Methoxychalcone | 4'-Methoxychalcone, found in citrus, is chalcone derivative that has shown diverse pharmacological properties, including anti-tumor and anti-inflammatory activities. 4'-Methoxychalcone significantly enhanced adipocyte differentiation, in part, by its potent effects on PPARγ activation and by its reverse effect on TNF-α. |
| S3939 | 4'-Methoxyresveratrol | 4-Methoxyresveratrol is a stibenoid found in the Chinese herb Gnetum cleistostachyum. 4'-Methoxyresveratrol alleviates AGE-induced inflammation through suppressing RAGE-mediated MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation. |
| S5156 | 4-Methoxysalicylaldehyde | 4-Methoxysalicylaldehyde (2-Hydroxy-4-methoxybenzaldehyde), a naturally occurring product, has a range of industrial applications in the preparation of organic compounds, drugs and therapeutic agents. |
| S5160 | 4-Methoxysalicylic acid | 4-Methoxysalicylic acid (2-Hydroxy-p-anisic Acid), an arabinose derivative, is used in the synthesis of 1,3,4-oxadiazole derivatives. |
| S2987 | 4-Methyl-2-oxovaleric acid | 4-Methyl-2-oxovaleric acid (Ketoleucine, 4-MOV, KIC, 4-Methyl-2-oxopentanoic acid, alpha-Ketoisocaproic acid, alpha-ketoisocaproate, 2-Oxoisohexanoate) is released by Astrocytes to neurons and can be reaminated by aminotransferase to leucine. 4-Methyl-2-oxovaleric acid reduces the rate of protein degradation in skeletal muscle. 4-Methyl-2-oxovaleric acid acts as an uncoupler of oxidative phosphorylation (OXPHOS) and as a metabolic inhibitor possibly through its inhibitory effect on alpha-ketoglutarate dehydrogenase (oxoglutarate dehydrogenase complex, OGDC) activity. |
| S6029 | 4-Methyl-n-octanoic Acid | 4-Methyl-n-octanoic Acid is a flavouring ingredient. |
| S3704 | 4-Methylbenzylidene camphor | 4-Methylbenzylidene camphor (Enzacamene, 4-MBC) is an organic camphor derivative that is used in the cosmetic industry for its ability to protect the skin against UV, specifically UV B radiation. |
| S5616 | 4-Methylcatechol | 4-Methylcatechol (P-Methylcatechol, 3,4-Dihydroxytoluene, Homocatechol) is an inducer of nerve growth factor. It is used to synthesize antimicrobial and antioxidant. |
| S4966 | 4-Methylesculetin | 4-methylesculetin is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase (MPO) activity and reduces IL-6 level. |
| S5519 | 4-Methylsalicylic acid | 4-Methylsalicylic acid (m-Cresotic acid, 2-Hydroxy-4-methylbenzoic acid, m-Cresotinic acid, 2-Hydroxy-p-toluic acid) is used to inhibit the medium chain acyl-CoA synthetase. |
| S2256 | 4-Methylumbelliferone (4-MU) | 4-Methylumbelliferone is a hyaluronic acid (HA) synthesis inhibitor with an IC50 of 0.4 mM. |
| E4012 | 4-Methylumbelliferyl beta-D-glucopyranoside | 4-Methylumbelliferyl beta-D-glucopyranoside(MUD) is a β-D-glucoside, is a fluorogenic substrate for β-glucosidase. It is utilized in the assay of beta-glucosidase activity. |
| E4015 | 4-Methylumbelliferyl N-acetyl-beta-D-glucosaminide | 4-Methylumbelliferyl N-acetyl-beta-D-glucosaminide is a fluorogenic substrate used for assays of N-acetyl-β-D-glucosaminidase (NAGase). |
| S6278 | 4-Methylvaleric acid | 4-Methylvaleric acid (Isocaproic acid, Isocaproate, 4-Methylpentanoate, 4-Methylpentanoic acid) is an important metabolite in early placentas enabling the convertion from cholesterol to pregnenolone to Dehydroepiandrosterone (DHEA). |
| E0335 | 4-MMPB | 4-MMPB, a selective inhibitor of 15-lipoxygenase (15-LO) with an IC50 of 18 μM, shows IC50s of 19.5 μM and 19.1 μM for soybean 15-lipoxygenase (SLO) and human 15-lipoxygenase-1 (15-LOX-1), respectively. |
| S4782 | 5-methoxyflavone | 5-methoxyflavone is a novel DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity. |
| S6319 | 5-Methoxysalicylic acid | 5-Methoxysalicylic acid is a chemical compound belongs to the class of organic compounds known as m-methoxybenzoic acids and derivatives. |
| S6324 | 5-Methoxytryptamine | 5-Methoxytryptamine (Mexamine, Methoxytryptamine) is a tryptamine derivative that acts as a full agonist at the 5-HT1, 5-HT2, 5-HT4, 5-HT6, and 5-HT7 receptors. |
| S9381 | 5-Methyl furfural | 5-Methyl furfural is an important chemical intermediate. |
| S5907 | 5-Methyl-2'-deoxycytidine | 5-Methyl-2'-deoxycytidine (5-Me-dC, 5-Methyldeoxycytidine, 5MedCyd) is a minor component found in most eukaryotic DNA. |
| S9139 | 5-Methyl-7-methoxyisoflavone | 5-Methyl-7-methoxyisoflavone is a chemical compound commonly used as a bodybuilding supplement. |
| S6138 | 5-Methylcytidine | 5-Methylcytidine is a modified nucleoside derived from 5-methylcytosine. It is found in ribonucleic acids of animal, plant, and bacterial origin. |
| S6021 | 5-Methylcytosine | 5-Methylcytosine, a methylated form of the DNA base cytosine, is a major epigenetic mark in the nuclear DNA in mammals and may be involved in the regulation of gene transcription. |
| S6156 | 5-Methyluridine | 5-Methyluridine (Ribothymidine, Ribosylthymine, Thymine riboside) is a pyrimidine nucleoside that acts as an human endogenous metabolite. |
| S0577 | 6-Maleimidohexanoic acid N-hydroxysuccinimide ester | 6-Maleimidohexanoic acid N-hydroxysuccinimide ester (EMCS) is a heterobifunctional cross-linking reagent. EMCS is used as a unique and useful reagent for preparation of hapten conjugate and enzyme immunoconjugates. |
| S4504 | 6-Mercaptopurine (6-MP) Monohydrate | 6-Mercaptopurine (6-MP) Monohydrate is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA. |
| S5302 | 6-Methoxy-2-naphthoic acid | 6-Methoxy-2-naphthoic acid (6-Methoxy-2-naphthalenecarboxylic acid) is an modulator of NMDAR. |
| S0906 | 6-Methoxydihydrosanguinarine | 6-Methoxydihydrosanguinarine is an lkaloid isolated from the fruits of M.cordata. 6-Methoxydihydrosanguinarine shows strong cytotoxicity against MCF-7 and SF-268 cell lines with IC50 values of 0.61 μM and 0.54 μM, respectively. |
| S4802 | 6-Methylcoumarin | 6-Methylcoumarin (Toncarine), a synthetic fragrance widely used in cosmetics, belongs to the class of organic compounds known as coumarins and derivatives. |
| S4780 | 7-Methoxy-4-methylcoumarin | 7-Methoxy-4-methylcoumarin is a coumarin derivative and fluorescent label. 7-Methoxy-4-methylcoumarin has an antimicrobial activitiy against both gram positive and gram negative bacterial stains. 4-Methylherniarin displays good activity against B. subtilis and S.sonnei with IC50 of 11.76 μg/ml and 13.47 μg/ml, respectively. |
| S5163 | 7-Methoxycoumarin | 7-Methoxycoumarin (Herniarine), also known as Herniarin, is a methoxy derivative of coumarin and substrate for dealkylase. It has been used in the synthesis of anti-first-pass effect compounds and detergents. |
| S1323 | 7-Methoxyisoflavone | 7-Methoxyisoflavone (MIF) is a potent activator of adenosine monophosphate-activated protein kinase (AMPK). |
| E0656 | 7-Methylcoumarin | 7-Methylcoumarin can inhibit the growth of S. aureus and the growth of Gram-positive bacteria within a concentration of 0.8–3.6 μg/ml, and also has a strong hepatoprotective activity. |
| S3265 | 9''-Methyl salvianolate B | 9''-Methyl salvianolate B (9'-methyllithospermate B, 9'-Methyl lithospermate B, 9'''-Methyl salvianolate B) is an active constituent in ethanol extract of Radix Salviae Miltiorrhizae. |
| S2986 | 9-Methoxycanthin-6-one | 9-Methoxycanthin-6-one is present in intact plant parts and in callus tissues of different explants with anti-tumour activity. |
| S0982 | m-3M3FBS | m-3M3FBS is a potent activator of phospholipase C (PLC) that stimulates a transient intracellular calcium concentration increase in neutrophils. m-3M3FBS induces apoptosis in monocytic leukemia cells. |
| S0603 | m-PEG12-amine | m-PEG12-amine is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. m-PEG12-amine is also a non-cleavable 12-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). |
| E1069 | M2912 | M2912 (MSC2504877) is a very potent TNKS1/TNKS2 inhibitor (IC50=0.6 nM for TNKS1) with exquisite selectivity over other PARP family enzymes and favorable compound properties. This inhibitor potently modulates the Wnt/β-catenin pathway by elevating the levels of axin2 (EC50=17 nM) and tankyrase in DLD1 cells in a dose-dependent manner resulting in reduced cellular Wnt reporter activity. |
| S0187 | M2I-1 | M2I-1 is an inhibitor of Mad2 (mitotic arrest deficient 2) targeting the binding of Mad2 to Cdc20, an essential protein-protein interaction (PPI) within the SAC (spindle assembly checkpoint). |
| E2640 | M2N12 | M2N12 is a potent and highly selective cell division cycle 25C protein phosphatase (Cdc25C) inhibitor with an IC50 value of 0.09 μM, also shows promising activity against Cdc25A and Cdc25B with IC50 values of 0.53 μM and 1.39 μM, respectively. |
| E1512 | M3541 | M3541 is a potent and selective inhibitor of ATM kinase activity with an IC50 value of 0.25 nM in cell-free assays. M3541 suppresses double-strand breaks (DSB) repair, clonogenic cancer cell growth and potentiates antitumor activity of ionizing radiation in cancer cell lines. |
| S9965 | M435-1279 | M435-1279 is a UBE2T inhibitor, inhibiting the Wnt/β-catenin signaling pathway hyperactivation through blocking UBE2T-mediated degradation of RACK1. |
| S3190 | m6A (N6-methyladenosine) | m6A (N6-methyladenosine) is a base modified analog of adenosine and is found as a minor nucleoside in natural RNAs. |
| A5875 | M6PR Rabbit Recombinant mAb | M6PR Rabbit Recombinant mAb detects endogenous levels of total M6PR. |
| E2838 | M7583 | M7583 is a potent, orally active, ATP-competitive, and highly selective irreversible BTK inhibitor with IC50 and Ki of 1.5 nM and 11.9 nM, respectively. |
| S9387 | Maackiain | Maackiain (Demethylpterocarpin) is a pterocarpan that is widely distributed in leguminous plants. It has anticancer and antimicrobial effects. |
| S6771 | MAC-545496 | MAC-545496 is a nanomolar glycopeptide-resistance-associated protein R(GraR) inhibitor with strong binding affinity to the full-length GraR protein (Kd ≤ 0.1 nM). MAC-545496 can reverse β-lactam resistance in methicillin-resistant strains and synergize with CAMPs. MAC-545496 shows remarkable activity in macrophages and attenuates S. aureus virulence in a G. mellonella larvae infection model. |
| E3464 | Maca extract | Maca Extract is extracted from Lepidium meyenii, which has effects on sexual dysfunction regulation, neuroprotective effects, action in memory enhancement, antidepressant, antioxidant, anti-cancer, and anti-inflammatory activities, and skin protection. |
| S8051 | Macitentan | Macitentan is an orally active, non-peptide, dual ETA/ETB (endothelin) receptor antagonist with IC50 of 0.5 nM/391 nM. |
| S3916 | Macranthoidin B | Macranthoidin B (Macranthoiside I) is a major bioactive saponin in rat plasma after oral administration of extraction of saponins from Flos Lonicerae. |
| L7300 | Macrocyclic Compound Library | A unique collection of 184 macrocyclic compounds used for high throughput screening(HTS) and high content screening(HCS). |
| A5586 | MacroH2A.1 Rabbit Recombinant mAb | MacroH2A.1 Rabbit Recombinant mAb detects endogenous level of total MacroH2A.1. |
| S9502 | Madecassic acid | Madecassic acid (Brahmic acid), a natural triterpene first isolated from C. asiatica, has diverse anti-inflammatory and anti-diabetic effects, blocking NF-κB activation in macrophages and causing by iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 inhibition. |
| S3843 | Madecassoside | Madecassoside (Asiaticoside A) is the main active triterpene constituent of Centella asiatica herbs, a traditional Chinese medicine for wound healing and scar management. |
| S0280 | Madrasin | Madrasin (DDD00107587) is a potent and cell-penetrant pre-mRNA splicing inhibitor. Madrasin interferes with the early stages of spliceosome assembly and stalls spliceosome assembly at the A complex. |
| S5094 | Maduramycin Ammonium | Maduramicin, which could be isolated from the actinomycete Actinomadura rubra, is an antiprotozoal agent used in veterinary medicine to prevent coccidiosis. |
| S3647 | Mafenide Acetate | Mafenide Acetate is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy. |
| S3697 | Mafenide hydrochloride | Mafenide is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy. |
| S6436 | magnesium 2-aminoacetate | Magnesium 2-aminoacetate (Magnesium glycinate) is essential for DNA and RNA synthesis, cellular repair, and maintaining the antioxidant status of the cell. |
| E0183 | Magnesium chloride | Magnesium chloride can reduce the activated thromboplastin times. |
| S4829 | Magnesium lactate trihydrate | Magnesium lactate, the magnesium salt of lactic acid, is a mineral supplement that is added to some food and beverages as an acidity regulator. |
| B23803 | < href="/bioreagents/magnetic-separator.html">Magnetic Separator | This Magnetic Separator is a proprietary machine, supportinga the magnetic beads series of products. A core tenent is the use of a superior magnetic, to ensure that magnetic separation step can be completed in a short time. |
| S9089 | Magnoflorine | Magnoflorine (Escholin, Thalictrin), an important compound in Aristolochia, was usually used as an anxiolytic chemical. It shows significant antioxidant activity as a DPPH free radical scavenger and inhibits α-tyrosinase. |
| S9188 | Magnoflorine chloride | Magnoflorine (Escholine, Thalictrine, Corytuberine methochloride), isolated from the rhizome of Sinomenium acutum and from Pachygone ovata, is usually used as an anxiolytic chemical with anti-oxidant, α-tyrosinase inhibitory and anti-inflammationary activities. |
| E3293 | Magnolia Bark Extract | Magnolia Bark Extract is extracted from the bark of Magnolia and can be used to manage diabetes and diabetes-related diseases. |
| E3508 | Magnolia Obovata Extract | Magnolia Obovata Extract is extracted from magnolia obovata, which has an anxiolytic effect through enhancement of the GABA receptor and anti-neuroinflammatory mechanisms. |
| E3778 | Magnoliae Flos Extract | Magnoliae Flos Extract is isolated from Flos Magnoliae, which is an oriental medicinal herb commonly used for symptomatic relief from allergic rhinitis, sinusitis, and headache, by inhibiting histamine release from mast cells and cytokine secretion from T cells. |
| S9102 | Magnolin | Magnolin is a natural compound abundantly found in Magnolia flos targeting ERK1 (IC50=87 nM) and ERK2 (IC50=16.5 nM) and inhibits cell transformation induced by tumor promoters such as epidermal growth factor (EGF). |
| S2321 | Magnolol | Magnolol (NSC 293099) is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. It can block TNF-α-induced NF-κB activation. |
| A2036 | Magrolimab (anti-CD47) | Magrolimab (anti-CD47) (5F9, GS-4721,Hu5F9 G4,ONO 7913) is a first-in-class macrophage immune checkpoint inhibitor that mainly binds to N-terminal pyroglutamate of CD47. |
| S8983 | MAK683 | MAK683 (EED inhibitor-1, example 2) is an inhibitor of embryonic ectoderm development (EED). MAK683 exhibits IC50 of 59 nM, 89 nM and 26 nM in EED Alphascreen binding, LC-MS and ELISA assay, respectively. |
| S0630 | Mal-PEG6-NHS ester | Mal-PEG6-NHS ester is a non-cleavable ADC linker containing a Maleimide group, 6-unit PEG and a NHS ester. |
| S0654 | Mal-PEG4-NHS ester | Mal-PEG4-NHS ester is a non-cleavable ADC linker containing a Maleimide group, 4-unit PEG and an NHS ester. |
| S6201 | Malachite green | Malachite green (Aniline green, Basic green 4, Diamond green B, Victoria green B) is a synthetic dyestuff and antimicrobial with potential carcinogenicity. |
| P1156 | Malantide | Malantide is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase, which is a highly specific substrate for PKA with a Km of 15 μM. |
| E3459 | Malan Extract | Malan Extract is extracted from dried whole grass of Wedelia chinensis (Osb.). |
| E3071 | Malaytea Scurfpea Extract | Malaytea Scurfpea Extract is extracted from Psoralea corylifolia L., which has antifungal activity and acts as a defence against pathogens. |
| S3330 | Maleamic acid | Maleamic acid ((Z)-4-Amino-4-oxobut-2-enoic acid) is an endogenous metabolite. |
| S3086 | Maleic acid | Maleic acid inhibits glutamate decarboxylase (GAD) activity, thus enhances acid sensitivity of Listeria monocytogenes. Maleic acid affects the extracellular GABA levels. |
| S3141 | Maleimide | Maleimide exhibits fluorescence quenching ability and can be used for the specific detection of thiol analytes as fluorogenic probes. Maleimide is also used for production of antibody-drug conjugate (ADC) which is used in cancer research. |
| S9001 | Malic acid | Malic acid (Hydroxybutanedioic acid, 2-Hydroxysuccinic acid) is a common, naturally occurring ingredient in many foods. It is the main acid found in apples and other fruits. |
| S3029 | Malonic acid | Malonic acid (MOA), one of the major dicarboxylic acids (DCAs) in aerosols, has been identified experimentally and computationally to be a strong acid. Malonic acid (MOA) acts as a mediate bridge for the formation of pure SA-A-based clusters. |
| S1137 | Malotilate | Malotilate (NKK105) is a drug used for the treatment of liver cirrhosis. Malotilate is a liver protein metabolism improved compound, which selectively inhibit the 5-lipoxygenase. |
| E3339 | Malt Extract | Malt extract is extracted from Hordeum vulgare, which is a rich source of soluble fiber, which helps improve digestion by optimizing good bacteria and minimizing bad bacteria. |
| A5583 | MALT1 Rabbit Recombinant mAb | MALT1 Rabbit Recombinant mAb detects endogenous level of total MALT1. |
| S3950 | Maltitol | Maltitol (Maltisorb, 4-O-α-glucopyranosyl-D-sorbitol) is a sugar alcohol (polyol) used as a sugar substitute. It is especially useful in the production of sweets, including sugarless hard candies, chewing gum, chocolates. |
| S9197 | Maltohexaose | Maltohexaose (Amylohexaose) is a polysaccharide with 6 units of glucose and can be classified as a maltodextrin. |
| S4940 | Maltol | Maltol (Larixinic acid, Palatone, Veltol) is a naturally occurring organic compound that is flavour enhancer and flavouring agent. |
| S4830 | Maltose | Maltose (Maltobiose, Malt Sugar, Beta-Maltose, D-Maltose), an non-essential nutrient that provides energy, is an intermediate in the intestinal digestion of glycogen and starch, and is found in germinating grains (and other plants and vegetables). |
| S4496 | Maltose monohydrate | Maltose (Maltobiose, Malt Sugar, Beta-Maltose, D-Maltose) monohydrate, an non-essential nutrient that provides energy, is an intermediate in the intestinal digestion of glycogen and starch, and is found in germinating grains (and other plants and vegetables). |
| S9195 | Maltotetraose | Maltotetraose, found in many foods, belongs to the class of organic compounds known as oligosaccharides. |
| S6121 | Maltotriose | Maltotriose is a trisaccharide consisting of three glucose molecules linked with α-1,4 glycosidic bonds. It is a common oligosaccharide metabolite found in human urine after maltose ingestion or infusion. |
| E3467 | Malt fruit Extract | Malt fruit Extract is extracted from the fruits of hordeum vulgare. |
| E3164 | Malvae Fructus Extract | Malvae Fructus Extract is extracted from Malvae Fructus, which helps to open the veins, induce diuresis and disperse swelling, dry pus, relieve diarrhea, quench thirst, and is used to treat ischuria and bladder stones. |
| S9456 | Mangafodipir Trisodium | Mangafodipir trisodium (MnDPDP), hepatocellular-specific contrast agent, is an efficacious inhibitor of CIPN (chemotherapy-induced peripheral neuropath) and other conditions caused by cellular oxidative stress. Mangafodipir trisodium shows no negative interference with the tumoricidal activity of chemotherapy. |
| S4827 | Manganese chloride | Manganese chloride occurs in nature as the mineral. It is used as a precursor for other manganese compounds. |
| S3808 | Mangiferin | Mangiferin (Alpizarin, Chinomin, Hedysarid) is a bioactive compound that demonstrates many health perspectives and has been used to prepare medicinal and food supplements. Mangiferin is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the NF-κB subunits p65 and p50. |
| E3470 | Mango leaf Extract | Mango Leaf Extract is extracted from the leaves of Mangifera indica, which attenuates muscle pain and damage and accelerates the recovery of muscle performance. |
| S2481 | Manidipine | Manidipine(CV-4093,(±)-Manidipine) is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive. |
| S2482 | Manidipine 2HCl | Manidipine 2HCl (CV-4093) is a HCl salt form of Manidipine, which is a calcium channel blocker with IC50 of 2.6 nM, used clinically as an antihypertensive. Phase 4. |
| E2969 | Mannan | Mannan is one of the major components of the yeast cell wall. It can be used to coat the microtiter wells to quantify the levels of mannose-binding lectin (MBL) using a mannan-binding enzyme-linked immunosorbent assay (ELISA). Mannan exhibits antiproliferative, antioxidant, and immunomodulatory properties. |
| A5697 | Mannose Receptor(CD206) Rabbit Recombinant mAb | Mannose Receptor(CD206) Rabbit Recombinant mAb detects endogenous level of total Mannose Receptor(CD206). |
| S0491 | Manogepix (E1210) | Manogepix (E1210, MGX, APX001A) is a broad-spectrum and orally active antifungal agent that inhibits Gwt1/Gwt1p (GPI-anchored wall transfer protein 1), a protein that plays an important role in fungal cell wall integrity. |
| E3599 | Mantis egg-case Extract | Mantis Egg-Case Extract is extracted from the ootheca of Tenodera sinensisi Saussure. |
| E0784 | MAO-B-IN-2 | MAO-B-IN-2 is a selective and competitive inhibitor of MAO-B and BChE with IC50 values of 0.51 and 7.00 μM, respectively. |
| A5179 | MAP1LC3A Rabbit Recombinant mAb | MAP1LC3A Rabbit Recombinant mAb detects endogenous level of total MAP1LC3A. |
| E0946 | MAP4K4-IN-3 | MAP4K4-IN-3 is a potent and selective Mitogen-activated protein kinase 4 (MAP4K4) inhibitor with an IC50 of 14.9 nM in kinase assay, an IC50 of 470 nM in cell assay. |
| L3400 | MAPK Inhibitor Library | A unique collection of 258 small molecule inhibitors used for MAPK signaling research. |
| A5829 | MAPKAP Kinase 2 Rabbit Recombinant mAb | MAPKAP Kinase 2 Rabbit Recombinant mAb detects endogenous levels of total MAPKAP Kinase 2 |
| S2517 | Maprotiline HCl | Maprotiline HCl is a selective noradrenalin re-uptake inhibitor, used in the treatment of depression. |
| E3773 | Marasmius Extract | Marasmius Extract is extracted from Marasmius androsaceus, which is the only analgesic medicinal fungi that can treat various types of neuralgia, the mechanism of its treatment of migraine has been paid more and more attention. |
| S2003 | Maraviroc | Maraviroc is a CCR5 antagonist for MIP-1α, MIP-1β and RANTES with IC50 of 3.3 nM, 7.2 nM and 5.2 nM in cell-free assays, respectively. Maraviroc is used in the treatment of HIV infection. |
| S1464 | Marbofloxacin | Marbofloxacin is a potent antibiotic inhibiting bacterial DNA replication. |
| S2687 | Mardepodect (PF-2545920) | Mardepodect (PF-2545920) is a potent and selective PDE10A inhibitor with IC50 of 0.37 nM, with >1000-fold selectivity over the PDE. |
| A2899 | Margetuximab (Anti-ERBB2 / HER2 / CD340) | Margetuximab (Anti-ERBB2 / HER2 / CD340) is a Fc-domain optimized IgG monoclonal antibody directed against the human epidermal growth factor receptor 2 (HER2) with potential immunomodulating and antineoplastic activities. MW: 146.1 KD. |
| S7156 | Marimastat (BB-2516) | Marimastat (BB-2516, TA2516) is a broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 with IC50 of 3 nM, 5 nM, 6 nM, 9 nM and 13 nM, respectively. Phase 3. |
| S7504 | Marizomib (Salinosporamide A) | Marizomib (Salinosporamide A) is a novel marine derived proteasome inhibitor which inhibits CT-L β5, C-L β1, and T-L β2 proteasome activities in human erythrocyte-derived 20S proteasomes with IC50 of 3.5 nM, 430 nM, 28 nM. |
| E2818 | MARK4 inhibitor 1 | MARK4 inhibitor 1 is a potent microtubule affinity-regulating kinase 4 (MARK4) inhibitor, with an IC50 of 1.54 μM for MARK4 inhibition assay. |
| E3007 | Marlea platanifolia Extract | Marlea platanifolia Extract is extracted from Marlea platanifoli that exhibits anti-inflammatory and analgesic activities. |
| S3283 | Marmesin | Marmesin (S-(+)-Marmesin, (+)-Marmesin, (S)-Marmesin) is a natural coumarin with COX-2 and 5-LOX dual inhibitory activity. |
| E0192 | Maropitant citrate | Maropitant citrate is a novel neurokinin type-1 (NK1) receptor antagonist with anti-inflammatory and analgesic properties. |
| S1064 | Masitinib | Masitinib is a novel inhibitor for Kit (c-Kit) and PDGFRα/β with IC50 of 200 nM and 540 nM/800 nM, weak inhibition to ABL and c-Fms. Phase 3. |
| E0814 | Masitinib mesylate | Masitinib mesylate (AB-1010 mesylate) is a potent, orally bioavailable, and selective inhibitor of c-Kit with IC50 of 200 nM for human recombinant c-Kit, also inhibits PDGFRα/β with IC50s of 540/800 nM, Lyn with IC50 of 510 nM for LynB, and, to a lesser extent, FGFR3 and FAK. |
| S9040 | Maslinic acid | Maslinic Acid (Crategolic Acid, 2α-Hydroxyoleanoic Acid), a Natural Triterpene, exerts a wide range of biological activities, i.e. antitumor, antidiabetic, antioxidant, cardioprotective, neuroprotective, antiparasitic and growth-stimulating. MA significantly suppresses the DNA-binding activity of NF-κB p65 in LPS-induced RAW 264.7 cells. |
| E3630 | Massa Medicata Fermentata Extract | Massa Medicata Fermentata Extract is extracted from Massa Medicata Fermentata. |
| E3463 | Masson pine needle Extract | Masson Pine Needle Extract is extracted from the needles of Pinus massoniana, which aids in gastrointestinal disorders and oxidative stress. |
| E3485 | Matcha Powder | Matcha Powder is extracted from Matcha, which has a high content of antioxidant and anti-inflammatory substances. |
| S8861 | Mavacamten (MYK-461) | Mavacamten (MYK-461, SAR439152) is a small-molecule modulator of cardiac myosin that targets the underlying sarcomere hypercontractility of hypertrophic cardiomyopathy (HCM), one of the most prevalent heritable cardiovascular disorders. |
| S6685 | Mavacoxib | Mavacoxib (Trocoxil) is a selective, long-acting cyclooxygenase-2 (COX-2) inhibitor. Mavacoxib is a novel nonsteroidal anti-inflammatory drug (NSAID). |
| E1318 | Mavorixafor | Mavorixafor (AMD-070) is a potent, selective CXCR4 antagonist, with an IC50 value of 13 nM against CXCR4 125I-SDF binding. |
| S0765 | MAZ51 | MAZ51 is a potent and selective inhibitor of vascular endothelial growth factor receptor (VEGFR)-3 (Flt-4) tyrosine kinase. MAZ51 induces cell rounding and G2/M cell cycle arrest in glioma cells through phosphorylation of Akt/GSK3β and activation of RhoA. MAZ51 inhibits the proliferation and induces the apoptosis of a variety of non-VEGFR-3-expressing tumor cell lines. |
| E0337 | MBCQ | MBCQ is a potent and selective cGMP-specific phosphodiesterase (PDE5) inhibitor with an IC50 of 19 nM. |
| A5937 | MBD2 Rabbit Recombinant mAb | MBD2 Rabbit Recombinant mAb detects endogenous levels of total MBD2. |
| S0378 | MBP146-78 | MBP146-78 is a potent and selective inhibitor of cyclic GMP(cGMP)-dependent protein kinases/Protein Kinase G (PKG) and displays cytostatic activity against Toxoplasma gondii. |
| S6669 | MC-Val-Cit-PAB | MC-Val-Cit-PAB,also known as MC-Val-Cit-PAB-OH,is a cathepsin cleavable ADC peptide linker and is used for making ADC conjugate (antibody-drug conjugate). |
| S6832 | MC-VC-PAB-PNP | MC-Val-Cit-PAB-PNP (Mc-Val-Cit-PABC-PNP) is a cathepsin cleavable ADC peptide linker that is applicable to the synthesis of antibody-drug conjugates (ADCs). |
| S8809 | MC180295 | MC180295 ((rel)-MC180295) is a novel potent and selective CDK9 inhibitor with an IC50 of 5 nM and is at least 22-fold more selective for CDK9 over other CDKs. |
| S7913 | MCB-613 | MCB-613 is a potent steroid receptor coactivator (SRC) stimulator. |
| S8930 | MCC950 | MCC950 (CP-456773, CRID3) is a potent and selective inhibitor of NLRP3 (NOD-like receptor (NLR) family, pyrin domain-containing protein 3) with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively. |
| S7809 | MCC950 Sodium | MCC950 Sodium is a potent, selective inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs; but not the AIM2, NLRC4 or NLRP1 inflammasomes. |
| A5172 | MCM2 Rabbit Recombinant mAb | MCM2 Rabbit Recombinant mAb detects endogenous level of total MCM2. |
| A5489 | MCM5 Rabbit Recombinant mAb | MCM5 Rabbit Recombinant mAb detects endogenous level of total MCM5. |
| S6905 | MCP110 | MCP110 is an inhibitor of Ras/Raf-1 interaction. MCP110 disrupts the interaction of activated Ras with Raf and is potential for the treatment of human tumors. |
| S9842 | MCU-i4 | MCU-i4 is a negative modulator of the mitochondrial calcium uniporter (MCU) complex that directly binds a specific cleft in MICU1 and decreases mitochondrial Ca2+ influx. |
| S6573 | MD2-IN-1 | MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD value of 189 μM. |
| S0139 | MD2-TLR4-IN-1 | MD2-TLR4-IN-1 (Compound 22m) is a potent inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4). MD2-TLR4-IN-1 (compound 22m) inhibits lipopolysaccharide (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 of 0.89 μM and 0.53 μM, respectively. |
| S7162 | Mdivi-1 | Mdivi-1 (Mitochondrial division inhibitor 1) is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with IC50 of 1-10 μM. Mdivi-1 attenuates mitophagy and enhances apoptosis. |
| S7394 | MDL-28170 | MDL-28170 (Calpain Inhibitor III) is a potent and selective calpain inhibitor of calpain that penetrates the blood-brain barrier and inhibits brain cysteine protease activity after systemic administration. MDL-28170 is also an inhibitor of γ-secretase. |
| E1267 | MDL-800 | MDL 800 is an allosteric activator of sirtuin 6 (SIRT6). It selectively activates SIRT6 deacetylase activity over SIRT1-5 and -7 and histone deacetylase 1 (HDAC1) and HDAC2-11 deacetylase activity in cell-free assays at 100 µM. It induces histone deacetylation, and reduces proliferation of BEL-7405 hepatocellular carcinoma (HCC) cells with EC50 of 90.4 µM. |
| S0825 | MDR-652 | MDR-652 is a potent and specific agonist of transient receptor potential vanilloid 1 (TRPV1) with Ki of 11.4 nM and 23.8 nM for hTRPV1 and rTRPV1, respectively. MDR-652 has excellent and dose-dependent analgesic activity. |
| S4610 | Mebendazole | Mebendazole is a synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake. |
| S5027 | Mebeverine Hydrochloride | Mebeverine (Duspatalin, Duspatal, Colofac), a 3-phenylethylamine derivative of methoxybenzamine, acts as a musculotropic antispasmodic agent. |
| S5018 | Mebhydrolin napadisylate | Mebhydrolin Napadisylate (Diazoline, Diazolin, Incidal, Omeril) is classified as an antihistamine drug classes used to treat allergies. |
| E0949 | Mebicar | Mebicar, a derivative of bicyclic bis-ureas, inhibits the orientation reaction in albino mice, potentiates the action of narcotic hypnotics, abolishes the conditioned reflex reaction of avoidance, displays central adrenolytic activity, interferes with the norepinephrine metabolism in the brain stem. |
| S3587 | Mebrofenin | Mebrofenin (SQ 26962) is a type of iminodiacetic acid (IDA) that is available as a ready to use the kit for radio-labeling with Technetium-99m (Tc-99m). Tc-99m Mebrofenin is used clinical for hepatobiliary scintigraphy. |
| S9459 | Mecamylamine Hydrochloride | Mecamylamine hydrochloride is an orally active, nonselective, noncompetitive nAChR(nicotinic acetylcholine receptors) antagonist.It is also a ganglionic blocker and can across the blood-brain barrier. It can be used in the research of neuropsychiatric disorders, hypertension, antidepressant area. |
| S2074 | Mecarbinate | Mecarbinate (Dimecarbin) is a chemical intermediate of arbidol hydrochloride. |
| S4252 | Mechlorethamine HCl | Mechlorethamine is the prototype of alkylating agents, it works by binding to DNA, crosslinking two strands and preventing cell duplication. |
| S1986 | Meclizine 2HCl | Meclizine (NSC 28728,Meclozine dihydrochloride) is a histamine H1 receptor antagonist used to treat nausea and motion sickness, has anti-histamine, anti-muscarinic and anti-oxidative phosphorylation properties, also an agonist ligand for mCAR (constitutive androstane receptor) and an inverse agonist for hCAR. |
| S4295 | Meclofenamate Sodium | Meclofenamate Sodium(CI 583) is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM, respectively, used in the treatment of joint, muscular pain, arthritis and dysmenorrhea. Meclofenamate Sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor. |
| S4280 | Meclofenoxate (Centrophenoxine) HCl | Meclofenoxate (Centrophenoxine) HCl is an anti-aging drug used to treat the symptoms of senile dementia and Alzheimer's disease, and also inhibits the activity of cholinephosphotransferase. |
| S3060 | Medetomidine HCl | Medetomidine is a selective α2-adrenoceptor agonist, with Ki of 1.08 nM, exhibts 1620-fold selectivity over α1-adrenoceptor. |
| E1768 | MEDICA16 | MEDICA16 is an inhibitor of ATP-citrate lyase and also acts as an agonist of G protein-coupled receptor 40 (GPR40). It functions to blunt the development of insulin resistance in the JCR:LA-cp rat as well as it is a potent triacylglycerol-lowering agent. |
| S3305 | Medicagenic acid | Medicagenic acid (Castanogenin), a bioactive triterpenoid pentacyclic glycoside isolated from Herniaria glabra L., has low xanthine oxidase, collagenase, elastase, and tyrosinase inhibitory activity. |
| E3893 | Medicago sativa Extract | Medicago sativa Extract is extracted from Medicago sativa L., which has antioxidant and cytotoxicity activity on skin cells. |
| L6800 | Medicine Food Homology Compound Library | A unique collection of 531 medicine food homology compounds used for high throughput screening (HTS) and high content screening (HCS). |
| S3635 | Medroxyprogesterone | Medroxyprogesterone (MP) is a synthetic pregnane steroid and a derivative of progesterone. It is a potent progesterone receptor agonist. |
| A5792 | MEF2A+MEF2C Rabbit Recombinant mAb | MEF2A+MEF2C Rabbit Recombinant mAb detects endogenous levels of total MEF2A and MEF2C. |
| S4078 | Mefenamic Acid | Mefenamic Acid (CI 473, CN-35355) is a competitive inhibitor of COX-1 and COX-2. |
| S4420 | Mefloquine HCl | Mefloquine HCl(Mefloquin hydrochloride) is a blood schizonticide by inhibiting hemozoin formation, used as an antimalarial drug. |
| S5738 | Megestrol | Megestrol, a synthetic progestin, is approved for the treatment of anorexia, cachexia, or an unexplained significant weight loss in patients with an acquired immunodeficiency syndrome diagnosis. Megestrol acetate (Megace) is one of the first progestational agents to be evaluated for use in the hormonal therapy of advanced breast cancer. |
| S1304 | Megestrol Acetate | Megestrol acetate (BDH1298, SC10363) is a synthetic progestogen, used to treat breast cancer and loss of appetite. |
| S1974 | Meglumine | Meglumine(Meglumin,Methylglucamine) is an amino sugar derived from sorbitol for THP-1 cells with IC50 of 22 μg/mL. |
| E2912 | MEHP | MEHP (Phthalic acid mono-2-ethylexyl ester) is a competitive inhibitor of CYP2C9 with IC50 of 6.37 μM. |
| A5810 | MEIS1 Rabbit Recombinant mAb | MEIS1 Rabbit Recombinant mAb detects endogenous levels of total MEIS1. |
| S6062 | MEISi-2 Dihydrochloride | MEISi-2 Dihydrochloride is a potent MEIS inhibitor (MEISi) that significantly inhibits MEIS-luciferase reporters in vitro.The solubility of this product is not good, please choose carefully for cell experiments! |
| S5327 | Meisoindigo | Meisoindigo (N-Methylisoindigotin, Methylisoindigotin, Dian III), a derivative of Indigo naturalis, is an active compound of a Chinese anti-leukemia medicine that has been effectively used in the treatment of chronic myelogenous leukemia (CML). In vitro cell line studies have shown that this agent might induce apoptosis and myeloid differentiation of acute myeloid leukemia (AML). |
| A5019 | MEK1 Rabbit Recombinant mAb | MEK1 Rabbit Recombinant mAb detects endogenous levels of total MEK1. |
| A5606 | MEK1/2 Rabbit Recombinant mAb | MEK1/2 Rabbit Recombinant mAb detects endogenous level of total MEK1/2. |
| A5009 | MEK2 Rabbit Recombinant mAb | MEK2 Rabbit Recombinant mAb detects endogenous levels of MEK2. |
| A5165 | MEK3 Rabbit Recombinant mAb | MEK3 Rabbit Recombinant mAb detects endogenous level of MEK3. |
| A5050 | MEK3/MEK6 Rabbit Recombinant mAb | MEK3/MEK6 Antibody detects endogenous levels of MEK3/MEK6. |
| A5672 | MEK5 Rabbit Recombinant mAb | MEK5 Rabbit Recombinant mAb detects endogenous level of total MEK5. |
| A5673 | MEK7 Rabbit Recombinant mAb | MEK7 Rabbit Recombinant mAb detects endogenous level of total MEK7. |
| A5124 | MEKK2 Rabbit Recombinant mAb | MEKK2 Rabbit Recombinant mAb detects endogenous level of total MEKK2. |
| A5748 | MEKK3 Rabbit Recombinant mAb | MEKK3 Rabbit Recombinant mAb detects endogenous levels of total MEKK3. |
| S9212 | Melamine | Melamine (Cyanuramide, Cyanurotriamide) is a widely-used intermediate, mainly employed as a raw material for producing melamine resin and is a chemical most often found in plastic materials. |
| E4013 | Melanin | Melanin is a unique pigment with myriad functions. It is multifunctional, providing defense against environmental stresses such as ultraviolet (UV) light, oxidizing agents and ionizing radiation. |
| P1073 | Melanotan I acetate | Melanotan I acetate is a synthetic analog of the naturally occurring melanocortin peptide hormone alpha-melanocyte stimulating hormone (α-MSH). |
| P1027 | Melanotan II | Melanotan II is an analog of the peptide hormone alpha-melanocyte stimulating hormone (α-MSH). |
| S1204 | Melatonin | Melatonin is a MT receptor agonist, used as a dietary supplement. Melatonin is a selective ATF-6 inhibitor and downregulates COX-2. Melatonin enhances mitophagy and regulates the homeostasis of apoptosis and autophagy. |
| S4130 | Meldonium | Meldonium (MET-88, Quaterin) is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption. |
| E0742 | Melengestrol Acetate | Melengestrol Acetate, progestational steroid suppress the AT3 tumour. |
| S4764 | Melezitose | Melezitose, also spelled melicitose, is a nonreducing trisaccharide sugar that is produced by many plant sap eating insects. |
| S4768 | Melibiose | Melibiose (Galalpha1-6Glcbeta) is a nondigestible disaccharide that consists of one galactose and one glucose moiety in an alpha (1-6) glycosidic linkage. |
| E3483 | Melissa axillaris Extract | Melissa axillaris Extract is extracted from the flower of Melissa axillaris. |
| S5034 | Melitracen hydrochloride | Melitracen hydrochloride (Thymeol) is a potential dopamine D1/2 receptor antagonist which has antidepressant properties. |
| S9794 | Melittin | Melittin (MLT, Forapin, Forapine) is an activator of phospholipase A2 (PLA2) that stimulates the activity of the low molecular weight PLA2, while it does not the increase the activity of the high molecular weight enzyme. |
| A5826 | MELK Rabbit Recombinant mAb | MELK Rabbit Recombinant mAb detects endogenous levels of total MELK |
| S0430 | MELK-8a Dihydrochloride | MELK-8a Dihydrochloride is a novel inhibitor of maternal embryonic leucine zipper kinase (MELK) with an IC50 of 2 nM. |
| S1734 | Meloxicam | Meloxicam is a selective COX inhibitor, used to relieve pain and fever effects. |
| S8266 | Melphalan | Melphalan (Alkeran, Sarcolysin, L-PAM) is a phenylalanine derivative of nitrogen mustard with antineoplastic activity.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing. |
| S2043 | Memantine HCl | Memantine HCl is an antagonist of NMDAR. It is also a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with IC50 of 1.12 μM and 242.4 μM, Ki of 0.51 μM and 84.4 μM, respectively. |
| S4779 | Menadiol Diacetate | Menadiol Diacetate (Vitamin K4, Acetomenaphthone, Kapilin) is a synthetic hydrophilic menadione compound, which is clinically used as hemostasis medicine. It induces caspase-3-related apoptosis pathway via mitochondrial dysfunction and DNA fragmentation. |
| S1949 | Menadione (Vitamin K3) | Menadione (Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement. |
| S5953 | Menadione bisulfite sodium | Menadione(Vitamin K3) bisulfite sodium, a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement. |
| S4886 | Menbutone | Menbutone (Genabilin, Naftobil, Genabilic acid), or genabilic acid, is a derivative of oxybutyric acid which acts as a choleretic stimulating secretion, a trypsinogen and a pepsinogen. |
| A5409 | Menin Rabbit Recombinant mAb | Menin Rabbit Recombinant mAb detects endogenous level of total Menin. |
| E0532 | Menotropin | Menotropin (Human Menopausal Gonadotrophin) is a hormonally active medication for the treatment of fertility disturbances, which are extracted from the urine of postmenopausal women. |
| E3053 | Mentha Arvensis Leaf Extract | Mentha Arvensis Leaf Extract is extracted from the leaf of Mentha Arvensis, which might be considered as a promising anticancer agent in breast cancer therapy in combination with synthesised GSNPs because they are less toxic and nonmutagenic and mediate caspase 9-dependent apoptosis. |
| E4112 | Menthol | Menthol is a natural analgesic compound that causes a feeling of coolness due to stimulation of ‘cold’ receptors by inhibiting Ca++ currents of neuronal membranes. |
| S3009 | Menthone | Menthone is one of the main volatile components of the essential oil of peppermint (Mentha piperita L.). Menthone is used as antioxidant agent and has a good compensatory effect with significant reduction in DNA damages in sperm cells. |
| S5032 | Mephenesin | Mephenesin (Decontractyl, Cresoxydiol, Memphenesin, Mephedan) is centrally acting muscle relaxant, a topical analgesic and may be an NMDA receptor antagonist. |
| S5392 | Mepivacaine | Mepivacaine (Carbocaine) is a local anesthetic indicated for infiltration, nerve block, and epidural anesthesia. |
| S3155 | Mepivacaine HCl | Mepivacaine is a tertiary amine used as a local anesthetic. |
| S1689 | Meprednisone | Meprednisone (NSC 527579, SCH 4358) is a glucocorticoid and a methylated derivative of prednisone. |
| S4077 | Mequinol | Mequinol (4-Methoxyphenol) is a depigmentation agent. |
| S6435 | Mequitazine | Mequitazine (LM-209) is a histamine H1 antagonist which competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. |
| E0052 | Merafloxacin | Merafloxacin (CI-934) is a fluoroquinolone antibacterial thats inhibit -1 frameshifting efficiency of SARS-CoV-2 and other betacoronaviruses. |
| E1769 | Merbarone | Merbarone(NSC 336628) is a catalytic inhibitor of topoisomerase II with IC50 of 120 μM, with anti-proliferative activity against human cancer cells. Merbarone acts primarily by blocking topoisomerase II-mediated DNA cleavage. |
| S6872 | Merbromin | Merbromin (Mercurochrome), a xanthene dye and an antibacterial agent, is the first of a series of antiseptics that contained mercury, also is a mixed-type inhibitor of 3CLpro due to its ability of increasing the KM and decreasing the Kcat of 3CLpro. |
| S1305 | Mercaptopurine (6-MP) | Mercaptopurine(6-MP) is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA. |
| S7014 | Merestinib (LY2801653) | Merestinib (LY2801653) is a type-II ATP competitive, slow-off inhibitor of Met (c-Met) tyrosine kinase with a dissociation constant (Ki) of 2 nM, a pharmacodynamic residence time (Koff) of 0.00132 min(-1) and t1/2 of 525 min. Merestinib (LY2801653) also inhibits MST1R, AXL, ROS1, MKNK1/2, FLT3, MERTK, DDR1 and DDR2 with IC50 of 11 nM, 2 nM, 23 nM, 7 nM, 7 nM, 10 nM, 0.1 nM and 7 nM, respectively. |
| E0097 | Mericitabine | Mericitabine (RG 7128, R-7128, PSI 6130 diisobutyrate) is a nucleoside inhibitor of the HCV NS5B polymerase that acts as an RNA chain terminator and prevents elongation of RNA transcripts during replication. |
| S6689 | Merimepodib | Merimepodib (Merimempodib, MMPD, VI-21,497, VX-497) is a potent, specific, and reversible inosine monophosphate dehydrogenase(IMPDH) inhibitor with antiviral activity against hepatitis C virus (HCV) and a variety of DNA and RNA viruses in vitro.Merimepodib is an immunosuppressive agent. |
| S1381 | Meropenem | Meropenem (SM 7338) is an ultra-broad spectrum injectable antibiotic. |
| S4846 | Meropenem Trihydrate | Meropenem is a broad-spectrum antibacterial agent of the carbapenem family with a broad spectrum of in vitro activity against Gram-positive and Gram-negative pathogens. |
| A5615 | MerTK Rabbit Recombinant mAb | MerTK Rabbit Recombinant mAb detects endogenous level of total MerTK. |
| E2942 | MES | MES (2-Morpholinoethanesulphonic acid) is a buffering agent in biology and biochemistry. It is one of the Good's buffers, the buffer capacity ranging pH 5.5-7.0. It is broadly used to regulate pH value for plants culture medium, reagent solution, and physiological experiments. |
| E2953 | MES hydrate | MES hydrate is one of the Good′s buffers, the most extensively used biological buffers. MES is a zwitterionic N-substituted aminosulfonic acid with a morpholinic ring. MES hydrate has been used in the MS (Murashige and Skoog) media for growth of Arabidopsis seedlings. It has been added in the cytoskeleton buffer during immunofluorescence study. |
| S3236 | Mesaconitine | Mesaconitine, one of the aconite alkaloids in Aconiti tuber, increases the [Ca2+]i level in endothelial cells by influx of Ca2+ from extracellular spaces. |
| S1681 | Mesalazine (5-ASA) | Mesalazine (5-ASA) is a specific inhibitor of TNFα-induced IKK activity, used to treat inflammatory bowel disease. |
| E3671 | Mesembryanthemum spectabile Extract | Mesembryanthemum Spectabile Extract is extracted from Mesembryanthemum Spectabile. |
| S1735 | Mesna | Mesna, a sulfhydryl compound that is used to reduce the incidence of hemorrhagic cystitis associated with certain chemotherapeutic agents. |
| S2125 | Mestranol | Mestranol is the 3-methyl ether of ethinyl estradiol, which is a potent estrogen receptor agonist and used as oral contraceptives. |
| A5006 | Met (c-Met) Rabbit Recombinant mAb | Met (c-Met) Rabbit Recombinant mAb detects endogenous levels of total Met (c-Met). |
| L3700 | Metabolism Compound Library | A unique collection of 3241 small molecules with biological activity in numerous metabolic pathway: glycometabolism, lipid metabolism, proteolysis, etc. |
| S5060 | Metadoxine | Metadoxine (Metadoxil, Metasin, pyridoxine-pyrrolidone carboxylat), also known as pyridoxine-pyrrolidone carboxylate, is a drug used to treat chronic and acute alcohol intoxication. Metadoxine is a novel 5-HT2B receptor antagonist with a possible therapeutic role in treating ADHD. |
| S4435 | Metamizole sodium hydrate | Metamizole (Dipyrone) sodium hydrate is a potent inhitior of cyclooxygenase (COX) with strong analgesic as well as antipyretic and spasmolytic properties. |
| S3472 | Metarrestin | Metarrestin is an orally active and specific perinucleolar compartment (PNC) inhibitor that disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription. Metarrestin blocks metastatic development and extends survival in mouse cancer models. |
| S3730 | Metaxalone | Metaxalone (Skelaxin, Methaxalonum, Zorane) is a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions. |
| S5958 | Metformin | Metformin (1,1-Dimethylbiguanide), a widely used drug for treatment of type 2 diabetes, activates AMP-activated protein kinase (AMPK) in hepatocytes. Metformin promotes mitophagy in mononuclear cells. Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153. |
| S1950 | Metformin HCl | Metformin HCl (1,1-Dimethylbiguanide HCl) decreases hyperglycemia in hepatocytes primarily by suppressing glucose production by the liver (hepatic gluconeogenesis). Metformin promotes mitophagy in mononuclear cells. Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153. |
| S3684 | Methacholine chloride | Methacholine (Mecholyl, Acetyl-β-methylcholine) is a synthetic choline ester that acts as a non-selective muscarinic receptor agonist in the parasympathetic nervous system but has little effects on the nicotinic receptors. |
| S2527 | Methacycline HCl | Methacycline HCl (Rondomycin) is a tetracycline antibiotic, and also an inhibitor of epithelial–mesenchymal transition (EMT) with IC50 of roughly 5 μM, used to treat various infections. |
| S4039 | Methazolamide | Methazolamide (CL 8490) is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively. |
| S9466 | Methenamine Hippurate | Methenamine Hippurate is the hippurate salt form of methenamine, a prodrug and inactive weak base that is hydrolyzed to formaldehyde in acid urine.Methenamine Hippurate is the component of Hiprex drug which has antibacterial activity. |
| S1609 | Methimazole | Methimazole (Tapazole, Thiamazole) is an antithyroid medicine. |
| S4494 | Methionine | Methionine (MRX-1024, D-Methionine) is an activitor of GABAA receptor that modulates neuronal activity. |
| S1736 | Methocarbamol | Methocarbamol (AHR 85) is a carbonic anhydrase inhibitor, used as a central muscle relaxant to treat skeletal muscle spasms. |
| E2686 | Methoprene | Methoprene is a growth-regulating insecticide that manifests its toxicity to target organisms by acting as a juvenile hormone agonist. |
| S1210 | Methotrexate | Methotrexate, analog of folic acid, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH. Methotrexate (MTX) induces apoptosis. |
| S5097 | Methotrexate disodium | Methotrexate sodium, an analog of folic acid, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH. Methotrexate (MTX) induces apoptosis. |
| S1952 | Methoxsalen | Methoxsalen (Xanthotoxin, NCI-C55903) is a naturally occurring photoactive substance found in the seeds of the Ammi majus (Umbelliferae) plant, used in the diagnosis and treatment of psoriasis; A CYP2A5/6 inhibitor. |
| S3640 | Methoxyphenamine Hydrochloride | Methoxyphenamine Hydrochloride (2-methoxy-N-methylamphetamine, OMMA) is a β-adrenergic receptor agonist of the amphetamine class used as a bronchodilator. |
| S1978 | Methscopolamine | Methscopolamine is a muscarinic acetylcholine receptor blocker. |
| S4057 | Methyclothiazide | Methyclothiazide is a substituted benzothiadiazide, used to treat high blood pressure and fluid retention caused by various conditions including heart disease. |
| S6230 | Methyl 3-aminopyrazine-2-carboxylate | Methyl 3-aminopyrazine-2-carboxylate is used in chemical synthesis. |
| S6280 | Methyl 3-indolyacetate | Methyl 3-indolyacetate is a phytohormone. |
| S6066 | Methyl 4-aminobutyrate HCl | Methyl 4-aminobutanoate (GABA methyl ester) is a methyl ester resulting from the formal condensation of gamma-aminobutyric acid with methanol. |
| S3985 | Methyl 4-hydroxybenzoate | Methyl 4-hydroxybenzoate (Methylparaben, Methyl p-hydroxybenzoate, Nipagin) is an anti-fungal agent often used in a variety of cosmetics, personal-care products and food preservatives. |
| S3873 | Methyl 4-hydroxycinnamate | Methyl 4-hydroxycinnamate (OMpCA) is a model chromophore of the Photoactive Yellow Protein (PYP). |
| S3091 | Methyl acetoacetate | Methyl acetylacetate (MAA, Acetoacetate methyl ester, Methyl 3-oxobutanoate, Methyl 3-oxobutyrate, Methyl acetoacetate, Methyl acetylacetate), an endogenous metabolite, is used as a chemical reagent used in the synthesis of pharmaceuticals. |
| S5372 | Methyl Aminolevulinate Hydrochloride | Methyl Aminolevulinate (Aminolevulinic acid methyl ester Hydrochloride, Methyl 5-aminolevulinate Hydrochloride) is a prodrug that is metabolised to protoporphyrin IX used in photodynamic therapy. |
| E2934 | Methyl cellulose (Viscosity:100000mPa.s) | Methyl cellulose ( hydroxypropyl methylcellulose, hypromellose) viscosity: 100000 mPa.s., a soluble methylcellulose ether, is used as a thickening agent, binder, film former, and hydrophilic matrix material. |
| S3994 | Methyl Cholate | Methyl Cholate (Cholic acid methyl ester) is methyl ester form of Cholic acid that is a primary bile acid mainly produced by the liver. |
| S6221 | Methyl cinnamate | Methyl cinnamate, an active component of Zanthoxylum armatum, is a widely used natural flavor compound with antimicrobial and tyrosinase inhibitor activities. Methyl Cinnamate Inhibits Adipocyte Differentiation via Activation of the CaMKK2--AMPK Pathway in 3T3-L1 Preadipocytes. |
| S6299 | Methyl cyclohexanecarboxylate | Methyl cyclohexanecarboxylate (Hexahydrobenzoic acid methyl ester, Methyl hexahydrobenzoate) is a flavouring ingredient and is used as a material for chemical synthesis. |
| S5139 | Methyl Dihydrojasmonate | Methyl dihydrojasmonate (Hedione, Kharismal) is a flavouring ingredien with the smell vaguely similar to jasmin. |
| S3863 | Methyl EudesMate | Methyl EudesMate (Methyl tri-O-methylgallate) is the methyl ester of 3,4.5-trimethoxybenzoic acid that used as an intermediate in the synthesis of pharmaceuticals. |
| S5755 | Methyl Eugenol | Methyl eugenol (4-allylveratrole, eugenyl methyl ether, O-methyleugenol), as a constituent in leaves, fruits, stems, and/or roots, is used as a flavoring agent, as a fragrance and as an anesthetic in rodents., |
| S5636 | Methyl furan-2-carboxylate | Methyl furan-2-carboxylate (Methyl pyromucate, Methyl 2-furoate) is found in cocoa and cocoa products. It is used in food flavouring and preparation of sesquiterpene lactone. |
| S3790 | Methyl gallate | Methyl Gallate (Methylgallate, Gallic acid methyl ester, Gallicin) is a plant polyphenol with antioxidant, anticancer, and anti-inflammatory activities. |
| S3006 | Methyl isoeugenol | Methyl isoeugenol (Methylisoeugenol) is an eugenol analogue isoeugenol isolated from Acori Tatarinowii Rhizoma. Methyl isoeugenol is a highly attractive lure for Z. diversus and would be a valuable inclusion as an attractant in monitoring and male annihilation programs. |
| S5759 | Methyl linoleate | Methyl linoleate (Linoleic acid methyl ester), found in cloves, is a fatty acid methyl ester of linoleic acid which is an essential fatty acid in mammalian nutrition and is used in the biosynthesis of prostaglandins and cell membranes. |
| S5682 | Methyl linolenate | Methyl linolenate (Linolenic acid methyl ester, Methyl alpha-linolenate) is a fatty acid methyl ester derived from alpha-linolenic acid and acts as a plant metabolite and an insect attractant. |
| E0609 | Methyl methanesulfonate | Methyl methanesulfonate (MMS), a DNA alkylating agent, modifies both guanine (to 7-methylguanine) and adenine (to 3-methlyladenine) to cause base mispairing and replication blocks, respectively. |
| S6231 | Methyl nicotinate | Methyl nicotinate (methyl pyridine-3-carboxylate) is an ester of methyl alcohol and nicotinic acid. It is a rubefacient. |
| S5833 | Methyl Nonadecanoate | Methyl nonadecanoate (Nonadecanoic Acid methyl ester) is a fatty acid methyl ester, which is less water soluble but more amenable for the formulation of nonadecanoate-containing diets and dietary supplements. |
| S5762 | Methyl Oleate | Methyl Oleate (oleic acid methyl ester, Methyl cis-9-Octadecenoate) is a methyl ester of oleic acid, which is a monounsaturated fatty acid and is one of the major components of membrane phospholipids. |
| S9383 | Methyl palmitate | Methyl palmitate (Methyl hexadecanoate, Palmitic acid methyl ester), a kind of fatty acid methyl ester, could be found in many plants and possesses acaricidal activity. |
| S3869 | Methyl protocatechuate | Methyl protocatechuate (Methyl 3,4-dihydroxybenzoate, 3,4-Dihydroxybenzoic acid methyl ester, Protocatechuic Acid Methyl Ester) is also known as Protocatechuic Acid Methyl Ester. Protocatechuic Acid, a dihydroxybenzoic acid, is a major metabolite of antioxidant polyphenols found in green tea with antioxidant and anti-inflammatory effects. |
| S3756 | Methyl salicylate | Methyl salicylate (Betula oil, Gaultheria oil, Methyl 2-hydroxybenzoate, Natural wintergreen oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. It is an agonist for TRPA1 and TRPV1. |
| S5756 | Methyl Stearate | Methyl Stearate (Methyl Octadecanoate, Stearic Acid methyl ester), found in cloves, is an antifoaming agent and fermentation nutrient. |
| S4787 | Methyl syringate | Methyl syringate (Syringic Acid Methyl Ester), a plant phenolic compound, is a specific and selective TRPA1 agonist. |
| S3630 | Methyl Vanillate | Methyl Vanillate, one of the ingredients in Hovenia dulcis Thunb, activates the Wnt/β-catenin pathway and induces osteoblast differentiation in vitro. |
| S5047 | Methyl α-D-mannopyranoside | Methyl α-D-mannopyranoside can be used as an intermediate for chemical sythesis and is a competitor inhibitor of the binding of mannose by Escherichia coli. |
| S3343 | Methyl β-D-Galactopyranoside | Methyl β-D-Galactopyranoside (Methyl beta-D-galactoside, Methylgalactoside) is an endogenous metabolite. |
| S2323 | Methyl-Hesperidin | Methyl Hesperidin is a flavanone glycoside (flavonoid) (C28H34O15) found abundantly in citrus fruits. Its aglycone form is called hesperetin. |
| S6827 | Methyl-β-cyclodextrin (MβCD) | Methyl-β-cyclodextrin (MβCD) is a cholesterol-removing agent mainly used for lipid raft disruption. Methyl-β-cyclodextrin induces caspase-dependent apoptosis in PEL cells and inhibits the growth and invasion of PEL cells without apparent adverse effects, suggesting the potential effective antitumor activities. |
| S6232 | Methylamine hydrochloride | Methylamine is used as a building block for the synthesis of many other commercially available compounds. |
| L6600 | Methylation Compound Library | A unique collection of 168 compounds used for researching the function of methylation in epigenetics,cancer,embryogenesis,etc. |
| S4623 | Methylbenactyzine Bromide | Methylbenactyzine Bromide (Gastrimade, Noinarin, Paragone, Semulgin) is a kind of muscarinic cholinergic receptor antagonist with antispasmodic activity. |
| S4994 | Methylcobalamin | Methylcobalamin (Mecobalamin, Vancomin, Methycobal, Cobametin) is one active form of vitamin B12 which can directly participate in homocysteine metabolism. It is used to treat some nutritional diseases and other diseases in clinic, such as Alzheimer's disease and rheumatoid arthritis. |
| S1642 | Methyldopa | Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg. |
| S4535 | Methylene Blue | Methylene Blue (Basic Blue 9, Tetramethylthionine chloride, methylthioninium chloride, CI-52015) is used as a dye in chromoendoscopy. It Inhibits tau filament formation with IC50 of 1.9μM. Also it inhibits soluble guanylyl cyclase. |
| S6309 | Methylguanidine HCl | Methylguanidine is a guanidine compound deriving from protein catabolism. |
| S3683 | Methylmalonate | Methylmalonate (Methylmalonic acid, Isosuccinic Acid, NSC 25201, MMA) is a dicarboxylic acid that can be derived from methylmalonyl-coenzyme A (methylmalonyl-CoA). |
| E2880 | methylnaltrexone bromide | Methylnaltrexone bromide is an antagonist of µ-opioid receptor that reduces the viability of lung cancer cells by inhibiting Src activation. |
| S3762 | Methylnonylketone | Methylnonylketone (2-Undecanone, IBI-246), also known as 2-Undecanone and IBI-246, is a natural non-toxic insect repellant compound. |
| S6012 | Methyloxalacetic acid diethyl ester | Methyloxalacetic acid diethyl ester (Diethyl 2-methyl-3-oxosuccinate, Diethyl methyloxobutanedioate, Diethyl oxalpropionate) is a member of the class of compounds known as beta-keto acids and derivatives. |
| S1733 | Methylprednisolone | Methylprednisolone is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis. |
| S5973 | Methylprednisolone Acetate | Methylprednisolone (NSC-19987, Medrol) acetate is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis. |
| S6588 | Methylprednisolone hemisuccinate | Methylprednisolone sodium succinate is a glucocorticoid used to treat a variety health issues including severe allergic reactions, asthma, autoimmune diseases, blood disorders, gastrointestinal diseases and endocrine disorders. |
| S6593 | Methylprednisolone sodium succinate | Methylprednisolone sodium succinate (U-9088, 6α-Methylprednisolone 21-hemisuccinate Sodium) is a corticosteroid medication that reduces inflammation. |
| S9300 | Methylprotodioscin | Methyl protodioscin, a bioactive natural compound isolated from Dioscorea collettii Makino (Dioscoreaceae), has numerous pharmacological activities, including anti-inflammation, lipid-lowering, and anticancer activities. |
| S3138 | Methylthiouracil | Methylthiouracil (NSC-193526, NSC-9378,MTU) is an antithyroid agent. Methylthiouracil suppresses the production TNF-α and IL-6, and the activation of NF-κB and ERK1/2. |
| S4339 | Meticrane | Meticrane is a diuretic that inhibits the reabsorption of sodium and chloride ions in the distal convoluted tubule. Meticrane is used to treat essential hypertension. |
| E0529 | Metipranolol | Metipranolol (Betamann) is a potent β-adrenergic receptor antagonist, possessing the beta-blocking potencies (pA2) of 8.3, 8.4 at guinea pig atrial β1-adrenoceptor and β2-adrenoceptor of the rat uterus, respectively, also is a potent displacer of 3H-DHA binding, ligand concentration 0.7 nM, possessing a Ki value of 39 ± 24 nM. |
| S5862 | Metoclopramide | Metoclopramide is a dopamine antagonist used for the treatment of nausea and vomiting. |
| S4289 | Metoclopramide HCl | Metoclopramide HCl(Metoclopramide hydrochloride) is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting. |
| S5949 | Metoclopramide hydrochloride hydrate | Metoclopramide hydrochloride (Clorpa, Gimoti, Maxolon, Reglan) hydrate is primarily a Dopamine receptor antagonist, with 5HT3 receptor antagonist and 5HT4 receptor agonist activity, and used as an antiemetic and gastroprokinetic. |
| S1610 | Metolazone | Metolazone (SR 720-22) is a diuretic that primarily used to treat congestive heart failure and high blood pressure. |
| S5430 | Metoprolol | Metoprolol is a cardioselective β1-adrenergic blocking agent with log Kd values of −7.26±0.07, −6.89±0.09, −5.16±0.12 for β1, β2, and β3 adrenoceptors, respectively. It is used for acute myocardial infarction, heart failure, angina pectoris and mild to moderate hypertension. |
| S1856 | Metoprolol Tartrate | Metoprolol Tartrate (CGP 2175E) is a selective β1 receptor blocker medication, used to treat hypertension and heart failure. |
| E0502 | Metrizoic acid | Metrizoic acid(Metrizoate) is a diagnostic radiopaque. The mechanism of action of metrizoic acid is as a X-Ray contrast activity. |
| S1907 | Metronidazole | Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa. |
| S5863 | Metronidazole Benzoate | Metronidazole Benzoate (Benzoyl metronidazole) is the benzoate ester of metronidazole, a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities. |
| S5341 | Metroprolol succinate | Metroprolol Succinate (Metoprolol succinate) is the succinate salt form of metoprolol, a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity. |
| S5416 | Metyrapone | Metyrapone (NSC-25265, SU-4885) is an inhibitor of the enzyme steroid 11-beta-monooxygenase (CYP11B1) that inhibits adrenal steroid synthesis. |
| S5797 | Metyrosine | Metyrosine (α-Methyltyrosine), an antihypertensive drug, is a tyrosine hydroxylase inhibitor. |
| S4223 | Mevastatin | Mevastatin (ML-236B,Compactin) is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself. |
| S5692 | Mexenone | Mexenone (Benzophenone-10) is a benzophenone-derived sunscreening agent. |
| S4225 | Mexiletine HCl | Mexiletine HCl (KO1173,Mexitil) belongs to Class IB anti-arrhythmic group of medicines, inhibits sodium channels to reduce the inward sodium current. |
| S8975 | Mezigdomide (CC-92480) | Mezigdomide (CC-92480) is a novel protein degrader and a cereblon E3 ligase modulator (CELMoD) that has anti-myeloma activity. |
| S4179 | Mezlocillin Sodium | Mezlocillin sodium is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. |
| E1098 | MF-094 | MF-094, a potent and selective USP30 inhibitor (IC50=0.12 μM), accelerates diabetic wound healing by inhibiting the NLRP3 inflammasome. |
| S6842 | MF-438 | MF-438 is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with IC50 of 2.3 nM for rSCD1. |
| E0612 | MF-766 | MF-766 is a highly potent, selective and orally active EP4 antagonist with a Ki of 0.23 nM. |
| S7386 | MG-101 (ALLN) | MG-101 (ALLN, Calpain inhibitor-1, Ac-LLnL-CHO) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins. |
| S2619 | MG132 | MG132 ((S,R,S)-(-)-MG132, Z-Leu-D-Leu-Leu-al) is a potent proteasome (ChTL, TL, and PGPH) inhibitor. MG132 also inhibits calpain (IC50=1.2 μM). |
| E2899 | MG132 SSS | MG132 SSS(Z-Leu-Leu-Leu-al, MG132) is a potent proteasome and calpain inhibitor with IC50 of 100 nM and 1.2 μM, respectively. |
| S7476 | MG149 | MG149 (Tip60 HAT inhibitor) is a potent histone acetyltransferase inhibitor with IC50 of 74 μM and 47 μM for Tip60 and MOF,respectively. |
| S1361 | MGCD-265 analog | MGCD-265 is a potent, multi-target and ATP-competitive inhibitor of c-Met and VEGFR1/2/3 with IC50 of 1 nM, 3 nM/3 nM/4 nM, respectively; also inhibits Ron and Tie2. Phase 1/2. |
| S9735 | MGH-CP1 | MGH-CP1 is a potent and selective inhibitor of transcriptional enhanced associate domain (TEAD) palmitoylation. MGH-CP1 exhibits dose-dependent and potent inhibition of TEAD2/4 auto-palmitoylation in vitro with IC50 of 710 nM and 672 nM, respectively. |
| A5545 | MHC class 1 Rabbit Recombinant mAb | MHC class 1 Rabbit Recombinant mAb detects endogenous level of total MHC class 1. |
| A5759 | MHC class I Rabbit Recombinant mAb | MHC class I Rabbit Recombinant mAb detects endogenous levels of total MHC class I. |
| S7614 | MHY-1685 | MHY-1685 is a novel mTOR inhibitor, which attenuates senescence by modulating autophagy through the inhibition of mTOR in human cardiac stem cells. |
| S7811 | MHY1485 | MHY1485 is a potent, and cell-permeable mTOR activator, and also potently inhibits autophagy. |
| S7815 | MI-136 | MI-136 can specifically inhibit the menin-MLL interaction. It inhibits DHT-induced expression of androgen receptor (AR) target genes. |
| S7618 | MI-2 (Menin-MLL Inhibitor) | MI-2 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM. |
| S7816 | MI-463 | MI-463 is a potent inhibitor of Menin-MLL interaction with an IC50 value of 15.3 nM. |
| S7817 | MI-503 | MI-503 is a potent and selective Menin-MLL inhibitor with IC50 of 14.7 nM. It shows pronounced growth suppressive activity in a panel of human MLL leukemia cell lines(GI50 at 250 nM-570 nM range), but only a minimal effect in human leukemia cell lines without MLL translocations. |
| S7649 | MI-773 (SAR405838) | MI-773 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1. |
| S1382 | Mianserin HCl | Mianserin (Bolvidon, Norval, Tolvon,ORG GB-94 HCl,Mianserin hydrochloride) is an potent antagonist of H1 histamine receptor and 5-HT serotonin receptors, used for the treatment of depression. |
| S4287 | Micafungin Sodium | Micafungin Sodium is an inhibitor of 1, 3-beta-D-glucan synthesis, used as an antifungal drug. |
| S2536 | Miconazole | Miconazole (Monistat,R18134) is an imidazole antifungal agent. |
| S1956 | Miconazole Nitrate | Miconazole (NSC 169434) Nitrate is an imidazole antifungal agent by inhibiting ergosterol biosynthesis and inducing ROS, used to treat vaginal yeast infections. |
| E0794 | MID-1 | MID-1 is a disruptor of MG53-IRS-1 (Mitsugumin 53-insulin receptor substrate-1) interaction, which can disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skeletal muscle, leading to elevated IRS-1 expression level and increased insulin signaling and glucose uptake. |
| S5560 | Midecamycin | Midecamycin (Espinomycin A, Medecamycin A1, Platenomycin B1, Rubimycin, Turimycin P3) is a naturally occuring macrolide antibiotic that acts by inhibiting bacterial protein synthesis. |
| S5735 | Midodrine | Midodrine belongs to the class of medications known as vasopressors. It is an adrenergic alpha-1 agonist. |
| S5734 | Midodrine hydrochloride | Midodrine hydrochloride is the hydrochloride salt form of midodrine, an adrenergic alpha-1 agonist used as a vasopressor. |
| S8064 | Midostaurin | Midostaurin is a multi-targeted kinase inhibitor, including PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50 ranging from 80-500 nM. |
| A5561 | MIF Rabbit Recombinant mAb | MIF Rabbit Recombinant mAb detects endogenous level of total MIF. |
| S2606 | Mifepristone | Mifepristone is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. Mifepristone promotes cell autophagy and apoptosis, decreases Bcl-2 level and increases Beclin1 level, accompanied by weakened interaction between Bcl-2 and Beclin1. |
| S0773 | Mifobate | Mifobate (SR-202), a potent and specific PPARγ antagonist, selectively inhibits Thiazolidinedione (TZD)-induced PPARγ transcriptional activity (IC50=140 μM). |
| S2589 | Miglitol | Miglitol is an oral anti-diabetic drug. |
| E1029 | Miglustat | Miglustat (Zavesca, N‐butyldeoxynojirimycin, OGT 918) is an orally administered ceramide glucosyltransferase inhibitor which prevents the lysosomal accumulation of glucocerebroside. |
| S8836 | MIK665 (S64315) | MIK665 (S64315) is an inhibitor of induced myeloid leukemia cell differentiation protein Mcl-1 with Ki value of 1.2 nM and has potential pro-apoptotic and antineoplastic activities. |
| S5055 | Milbemycin Oxime | Milbemycin Oxime is a broad spectrum anti-parasitic drug that is active against worms (anthelmintic) and mites (miticide). |
| S2751 | Milciclib | Milciclib is a potent, ATP-competitive CDK inhibitor for CDK2 with IC50 of 45 nM. It is >3-fold more selective for CDK2 than CDK1, 2, 4, 5, and 7, it's also an inhibitor of TRKA with IC50 of 53nM. Milciclib (PHA-848125) induces cell death through autophagy. Phase 2. |
| E0247 | Militarine | Militarine is a major chemical constituent of the tuber of Bletilla striata (Thunb.) Reichb.f., with a prominent neuroprotective effect. |
| E3512 | Milk thistle Extract | Milk Thistle Extract is extracted from Silybum marianum, which is a therapeutic agent for gastrointestinal cancer. |
| E3771 | Millet Extract | Millet Extract is derived from millet, which is the primary source of dietary fiber and polyphenols, which offers several health benefits such as antidiabetic, antioxidant, hypocholesterolemic, antimicrobial, and protective effects against diet-related chronic diseases. |
| S3140 | Milnacipran HCl | Milnacipran inhibits both norepinephrine transporter (NET) and norepinephrine transporter (SERT) with IC50 of 77 nM and 420 nM, respectively. |
| S2484 | Milrinone | Milrinone (Win 47203,Primacor) is a phosphodiesterase 3 (PDE3) inhibitor, used to increase the heart's contractility. |
| S3056 | Miltefosine | Miltefosine (Hexadecylphosphocholine) inhibits PI3K/Akt activity with ED50 of 17.2 μM and 8.1 μM in carcinoma cell lines A431 and HeLa, first oral drug for Visceral leishmaniasis, effective against both promastigotes and amastigotes. |
| E3250 | Mimosa Pudica Extract | Mimosa Pudica Extract is extracted from Mimosa Pudica, which has hypolipidemic activity. |
| E3249 | Mimosa Pudica Root Extract | Mimosa Pudica Root Extract is extracted from the root of Mimosa Pudica, which exhibits significant diuretic activity by increasing urine volume. |
| E1064 | MINA53 inhibitor (Compound 10) | MINA53 inhibitor (Compound 10, 2-((3-Phenylpropyl)thio)-3,4-dihydro-4-oxopyrimidine-5-carboxylic Acid) is a first-in-class inhibitor of the ribosomal oxygenase MINA53 with an IC50 of 1.5 μM in vitro. |
| A5761 | MINA53 Rabbit Recombinant mAb | MINA53 Rabbit Recombinant mAb detects endogenous levels of total MINA53. |
| S5663 | Minaprine dihydrochloride | Minaprine dihydrochloride is hydrochloride salt form of Minaprine, which acts as a reversible inhibitor of MAO-A in rats and weakly inhibit acetylcholinesterase in rat brain (striatum) homogenates. |
| S4226 | Minocycline HCl | Minocycline HCl is the most lipid soluble and most active tetracycline antibiotic, binds to the 30S ribosomal subunit, preventing the binding of tRNA to the mRNA-ribosome complex and interfering with protein synthesis. |
| S5057 | Minodronic acid | Minodronic acid (YM529, ONO-5920) is a third-generation nitrogen-cotaining bisphosphonate that is used for the treatment of osteoporosis. Minodronic acid is an aminobisphosphonate that is a selective antagonist of purinergic P2X2/3 receptors involved in pain. |
| S1383 | Minoxidil | Minoxidil (U-10858) is a vasodilator medication known for its ability to slow or stop hair loss and promote hair regrowth. Minoxidil is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. |
| S5228 | Minoxidil sulphate | Minoxidil (U-58838) is a potent direct-acting peripheral vasodilator that reduces peripheral resistance and produces a fall in blood pressure. |
| A3173 | Minretumomab (CC-49) | Minretumomab (CC-49) is a monoclonal antibody against TAG-72 (tumor-associated glycoprotein 72). Minretumomab can be used in cancer and immunity research. |
| E0356 | MIPS521 | MIPS521 is a positive allosteric modulator of the A1R that exhibits analgesic efficacy in rats in vivo. |
| S4009 | Mirabegron | Mirabegron (YM 178) is a selective β3-adrenoceptor agonist with EC50 of 22.4 nM. |
| E3066 | Miraclefruit Extract | Miraclefruit Extract is extracted from Synsepalum dulcificum, which has the potential to lower cholesterol levels and act as a natural source of cholesterol-lowering agent. |
| S8339 | Miransertib (ARQ 092) HCl | Miransertib (ARQ 092) HCl is a novel, orally bioavailable and selective AKT pathway inhibitor exhibiting a manageable safety profile among patients with advanced solid tumors. |
| S6811 | Miransertib (ARQ-092) | Miransertib (ARQ-092) is a potent, selective and orally bioavailable allosteric inhibitor of Akt with IC50s of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively. |
| S1036 | Mirdametinib (PD0325901) | Mirdametinib (PD0325901) is a selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM in cell-free assays, roughly 500-fold more potent than CI-1040 on phosphorylation of ERK1 and ERK2. Phase 2. |
| S8096 | Mirin | Mirin is a potent Mre11–Rad50–Nbs1 (MRN) complex inhibitor, and inhibits Mre11-associated exonuclease activity. Mirin inhibits MRN-dependent activation of ATM. |
| S5024 | Miriplatin | Miriplatin (SM-11355) is a derivative of cisplatin containing myristates as a carrier ligand. It is a novel lipophilic platinum complex developed to treat hepatocellular carcinoma.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation. |
| S5894 | Mirodenafil Dihydrochloride | Mirodenafil Dihydrochloride(SK-3530 dihydrochloride) is an oral phosphodiesterase type 5 (PDE-5) inhibitor used to treat erectile dysfunction (ED). |
| S6632 | Mirogabalin (DS-5565) | Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand that has been used in trials studying the treatment of Post-herpetic Neuralgia, Pain Associated With Fibromyalgia, and Diabetic peripheral neuropathic pain. |
| S2016 | Mirtazapine | Mirtazapine (Org3770,6-Azamianserin) is an adrenergic and seroton receptor antagonist, used to treat depression. |
| D4060 | Mirvetuximab-MMAE | Mirvetuximab-MMAE is an ADC targeting FOLR1 (folate receptor 1). It can be used in ovarian and other FRα-positive cancer research. MW :145.96 KD. |
| S4415 | Misoprostol | Misoprostol(SC29333) is a synthetic prostaglandin E1 (PGE1) analog that is used to prevent gastric ulcers, to treat missed miscarriage, to induce labor, and to induce abortion. |
| S6508 | Mitapivat | Mitapivat (AG-348) is an activator of a pyruvate kinase PKM2, an enzyme involved in glycolysis. |
| S2073 | Mitiglinide Calcium | Mitiglinide Calcium (KAD-1229) is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells. |
| E1081 | MiTMAB | MiTMAB is a selective dynamin inhibitor that targets the dynamin-phospholipid interaction. MiTMAB inhibits dynamin GTPase activity with a Ki of 940 nM. |
| S9733 | Mito-TEMPO | Mito-TEMPO (MT), a mitochondria-targeted superoxide dismutase mimetic, protects against the early phase of acetaminophen (APAP) hepatotoxicity by inhibiting peroxynitrite formation. Mito-TEMPO treatment inhibits APAP-induced RIP3 kinase expression. |
| L9900 | Mitochondria-Targeted Compound Library | A unique collection of 719 compounds targeting mitochondria, used for high-throughput screening (HTS) and high-content screening (HCS). |
| S3375 | Mitochondrial Fusion Promoter M1 | Mitochondrial fusion promoter M1 is a mitochondrial dynamic modulator that increases the expression of mitofusin 2, a mitochondrial outer membrane fusion protein, reduces brain mitochondrial dysfunction. Mitochondrial fusion promoter M1 alleviates brain damage in rats with cardiac ischemia/reperfusion injury. |
| S0881 | Mitochonic acid 5 (MA-5) | Mitochonic acid 5 (MA-5) reduces mitochondrial apoptosis via upregulation of mitophagy. Mitochonic acid 5 regulates mitophagy via Bnip3 through the MAPK-ERK-Yap signaling pathway. Mitochonic acid 5 modulates mitochondrial ATP synthesis. |
| A5754 | Mitofusin 2 Rabbit Recombinant mAb | Mitofusin 2 Rabbit Recombinant mAb detects endogenous levels of total Mitofusin 2. |
| A5388 | Mitofusin1 Rabbit Recombinant mAb | Mitofusin1 Rabbit Recombinant mAb detects endogenous levels of total Mitofusin1. |
| S8146 | Mitomycin C | Mitomycin C (Ametycine) is an antineoplastic antibiotic by inhibiting DNA synthesis, used to treat different cancers. Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing. |
| E0828 | Mitonafide | Mitonafide inhibits the activity of Mycobacterium tuberculosis NAD+ dependent DNA ligase A at concentrations of 50 µM. |
| E1252 | MitoPQ | MitoPQ (MitoParaquat), a mitochondria-targeted redox cycler, enables the selective generation of superoxide within mitochondria and is a useful tool to investigate the many roles of mitochondrial superoxide in pathology and redox signaling in cells and in vivo. |
| S8978 | MitoQ (Mitoquinone) mesylate | MitoQ (Mitoquinone) mesylate is a TPP-based, mitochondria-targeted antioxidant that blocks H2O2-induced intracellular ROS responses and protects against oxidative damage. This product is a waxy solid. |
| E1376 | MitoSOX Red | MitoSOX Red is a modified dihydroethidium (DHE) analog derived by the addition of a triphenylphosphonium group. It is a fluorescent probe used for imaging superoxide in the mitochondria of living cells. |
| S1732 | Mitotane | Mitotane (NCI-C04933), is an antineoplastic medication used in the treatment of adrenocortical carcinoma. |
| S2485 | Mitoxantrone 2HCl | Mitoxantrone 2HCl is a dihydrochloride salt of Mitoxantrone. Mitoxantrone is an inhibitor of type II topoisomerase and protein kinase C (PKC) with IC50 of 8.5 μM for PKC. Mitoxantrone inhibits cell proliferative growth of MCF-7/wt cells with IC50 of 0.42 μM. Mitoxantrone also induces apoptosis. |
| S5673 | Mivacurium chloride | Mivacurium chloride is a rapid, non-depolarising, neuromuscular blocking agent of short duration, used therefore as anesthetic, to provide skeletal muscle relaxation in minor surgical operations, in emergency surgical procedures of short to intermediate duration and during intubation of the trachea. |
| S8400 | Mivebresib (ABBV-075) | Mivebresib (ABBV-075) is a novel BET family bromodomain inhibitor. It binds bromodomains of BRD2/4/T with similar affinities (Ki of 1-2.2 nM) and highly selective for 18 bromodomain proteins tested (Kd > 1 μM; more than 600-fold selectivity vs. BRD4), but exhibits roughly 10-fold weaker potency towards BRD3 (Ki of 12.2 nM) and has moderate activity towards CREBBP (Kd = 87 μM; 54-fold selectivity vs. BRD4). Mivebresib(ABBV-075) efficiently triggers apoptosis in various tumor cell. |
| S8939 | Mizagliflozin (KWA 0711) | Mizagliflozin (KWA 0711) is a novel, potent, selective sodium glucose co-transporter 1 (SGLT1) inhibitor with Ki of 27 nM for human SGLT1. The selectivity ratio (Ki value for human SGLT2/Ki value for human SGLT1) of mizagliflozin is 303. Mizagliflozin shows the potential use for the amelioration of chronic constipation. |
| S2107 | Mizolastine | Mizolastine (SL 850324) is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions. |
| S1384 | Mizoribine | Mizoribine is an imidazole nucleoside and an immunosuppressant that inhibits HCV RNA replication with IC50 of ~ 100 μM for anti-HCV activity. Mizoribine is a selective inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH) and guanosine monophosphate synthetase. Mizoribine also inhibits SARS-CoV. |
| E1276 | MK-0159 | MK-015(Compound 37) is an inhibitor of CD38. MK-0159 inhibits human, mouse, and rat CD38 (cell-free assays) with IC50 values of 22, 3, and 70 nM, respectively. MK-0159 increases NAD+ (nicotinamide adenine dinucleotide) and reduces ADPR (adenosine diphosphate ribose) in whole blood and heart. |
| S2660 | MK-0752 | MK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM. Phase 1/2. |
| S2765 | MK-2048 | MK-2048 is a potent inhibitor of integrase (IN) and INR263K with IC50 of 2.6 nM and 1.5 nM, respectively. |
| S1078 | MK-2206 2HCl | MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. MK-2206 2HCl induces autophagy and apoptosis in cancer cells. Phase 2. |
| S2774 | MK-2461 | MK-2461 is a potent, multi-targeted inhibitor for c-Met(WT/mutants) with IC50 of 0.4-2.5 nM, less potent to Ron, Flt1; 8- to 30-fold greater selectivity of c-Met targets versus FGFR1, FGFR2, FGFR3, PDGFRβ, KDR, Flt3, Flt4, TrkA, and TrkB. Phase 1/2. |
| S6952 | MK-28 | MK-28 is a potent and selective activator of PERK. MK-28 exhibits an IC50 ~3-fold higher than CCT020312 in rescuing mutant huntingtin protein (mHtt)-expressing striatal neurons from apoptosis. MK-28 exhibits remarkable pharmacokinetic properties and high BBB penetration in mice. |
| S8200 | MK-4101 | MK-4101, a potent inhibitor of the Hedgehog pathway, shows anti-tumor activity through the inhibition of proliferation and induction of extensive apoptosis in tumor cells. |
| S2770 | MK-5108 | MK-5108 is a highly selective Aurora A inhibitor with IC50 of 0.064 nM in a cell-free assay and is 220- and 190-fold more selective for Aurora A than Aurora B/C, while it inhibits TrkA with less than 100-fold selectivity. MK-5108 (VX-689) induces autophagy. Phase 1. |
| S0505 | MK-571 sodium salt | MK-571 sodium salt (L-660711) is a selective, orally active antagonist of leukotriene D4 receptor. It is also an inhibitor of multidrug resistance-associated protein MRP4 (ABCC4) and ABCC1 (MRP1). |
| S1158 | MK-8245 | MK-8245 is an liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy. Phase 2. |
| S8701 | MK-8353 (SCH900353) | MK-8353 (SCH900353) is an orally bioavailable, selective, and potent ERK inhibitor that inhibits activated ERK1 and ERK2 in vitro, with IC50 values of 23.0 nM and 8.8 nM, respectively (IMAP kinase assay), and nonactivated ERK2, with an IC50 of 0.5 nM (MEK1-ERK2-coupled assay). |
| S8890 | MK-8719 | MK-8719 is a selective and potent small molecule inhibitor of the O-GlcNAcase (OGA) enzyme with ki of 7.9nM for hOGA. |
| E1031 | MK-8722 | MK-8722 is a potent, direct, allosteric activator of all 12 mammalian pan-AMPK complexes. |
| S2735 | MK-8776 (SCH 900776) | MK-8776 (SCH 900776) is a selective Chk1 inhibitor with IC50 of 3 nM in a cell-free assay. It shows 500-fold selectivity against Chk2. Phase 2. |
| S8236 | MK-886 | MK-886 is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist. |
| S6726 | MK1064 | MK1064 is a selective orexin 2 receptor antagonist (2-SORA) with an IC50 of 18 nM. |
| S6930 | MK2 Inhibitor III | MK2 Inhibitor III (MK2-IN-3) is an ATP-competitive MK2 (MAPKAP-K2) inhibitor with an IC50 value of 8.5 nM. |
| E2407 | MK2-IN-1 hydrochloride | MK2-IN-1 hydrochloride is a potent and selective MAPKAP-K2 (MK2) inhibitor with IC50 of 0.11 μM with a non-ATP competitive binding mode. |
| S8126 | MK571 | MK571 is a selective, orally active CysLT1 receptor(Cysteinyl leukotriene receptor) antagonist. |
| S6947 | MK6-83 | MK6-83 is a novel Transient receptor potential melastatin member 1 (TRPML1) activator that may be used as a potential pharmacological treatment option for a specific subgroup of MLIV patients. |
| S8286 | MKC-3946 | MKC3946 is a potent and soluble IRE1α endoribonuclease domain inhibitor which triggered modest growth inhibition in multiple myeloma cell lines, without toxicity in normal mononuclear cells. |
| S8875 | MKC8866 | MKC8866 (IRE1-IN-8866), a salicylaldehyde analog, is a specific IRE1α RNase inhibitor with IC50 of 0.29 μM for human IRE1α in vitro. |
| E1670 | MKI-1 | MKI-1(MASTL Kinase Inhibitor-1) is an small-molecule inhibitor of MASTL (microtubule-associated serine/threonine kinase-like) with an IC50 9.9 μM in kinase assay. It also exerts antitumor and radiosensitizer activities through PP2A-mediated c-Myc inhibition in breast cancer models. |
| A5243 | MKLP1 Rabbit Recombinant mAb | MKLP1 Rabbit Recombinant mAb detects endogenous level of total MKLP1. |
| S6718 | MKT-077 | MKT-077 (FJ-776) is a newly synthesized, highly water-soluble rhodacyanine dye that exhibits significant antitumor activity in a variety of model systems. |
| S0788 | ML 210 | ML-210 (CID 49766530) is a selective covalent inhibitor of cellular glutathione peroxidase 4 (GPX4) with EC50 of 0.04 μM and induces ferroptosis. ML-210 can selectively kill cells induced to express mutant RAS. ML-210 exhibits anti-cancer activity. |
| E2389 | ML-098 | ML-098 is an activator of the GTP-binding protein Rab7 with an EC50 of 77.62 nM. |
| S0989 | ML-180 | ML-180 (SR1848) is a potent inverse agonist of orphan nuclear receptor NR5A2 (Liver receptor homologue-1, LRH1) with IC50 of 3.7 μM. ML-180 has the potential for LRH-1-dependent cancers. |
| S6559 | ML-297 | ML-297 (VU 0456810, CID 56642816) is a potent and selective activator of Kir3.1/3.2 (G protein-coupled inwardly rectifying potassium, GIRK1/2) channel with EC50 of 0.16 μM and 1.8 μM for GIRK1/2 and GIRK1/4, respectively. ML-297 is potential for the treatment of epilepsy. |
| S8388 | ML-7 HCl | ML-7 is an inhibitor of smooth muscle myosin light chain kinase (MLCK) with a Ki value of 0.3 µM and displays reversible, ATP-competitive inhibition of Ca2+-calmodulin-dependent and -independent smooth muscle MLCKs. ML-7 also inhibits PKA and PKC with Ki of 21 μM and 42 μM, respectively. |
| S6847 | ML-9 HCl | ML-9 HCl (ML-9 hydrochloride) is a selective and potent inhibitor of Akt kinase, myosin light chain kinase (MLCK) and stromal interaction molecule 1 (STIM1). ML-9 HCl is also a potent inhibitor of Ca2+-permeable channels. ML-9 HCl is a lysosomotropic agent targeting autophagy and cell death. |
| S9926 | ML-SA1 | ML-SA1 (Mucolipin synthetic agonist 1) is an activator of TRPML channels. ML-SA1 also inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 values of ML-SA1 against DENV2 RNA and ZIKV RNA are 8.93 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral. |
| E0026 | ML-SI3 | ML-SI3 is a potent TRPML channel inhibitor with IC50s of 4.7 µM and 1.7 µM for TRPML1 and TRPML2, respectively. |
| S7686 | ML141 | ML141 (CID-2950007) is demonstrated to be a potent, selective and reversible non-competitive inhibitor of Cdc42 GTPase suitable for in vitro assays, with IC50 of 200 nM and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). ML141 is associated with an increase in p38 activation and may induce p38-dependent apoptosis/senescence. ML141 also protects neuroblastoma cells from metformin-induced apoptosis. |
| S2916 | ML161 (Parmodulin 2) | ML161 (Parmodulin 2) is an allosteric inhibitor of PAR1 with IC50 of 0.26 μM. |
| S4452 | ML162 | ML162 is a covalent inhibitor of cellular phospholipid glutathione peroxidase (GPX-4) that induces ferroptosis. |
| S7509 | ML167 | ML167 (CID 44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B. |
| S0793 | ML188 | ML188 is a non-covalent SARS-CoV 3CLpro inhibitor with IC50 of 1.5 μM. ML188 has antiviral activity. |
| S3470 | ML198 | ML198 is a novel activator of glucocerebrosidase (GCase) with an IC50 of 0.4 μM and does not inhibit the enzyme's action, but can facilitate its translocation to the lysosome. |
| S8691 | ML204 | ML204 is a novel, potent, and selective TRPC4 channel inhibitor with apparent IC50 values of about 1 μM in fluorescent intracellular Ca2+ assays and about 3 μM in whole-cell voltage clamp experiments. It exhibits some selectivity within the TRPC subfamily of channels and higher selectivity against other TRP channels and non-TRP channels. |
| S6553 | ML213 | ML213 (CID-3111211) is a selective KCNQ2 (Kv7.2) and KCNQ4 (Kv7.4) potassium channel opener with EC50 of 230 nM and 510 nM, respectively. |
| S0469 | ML216 | ML216 (CID-49852229) is a potent and selective inhibitor of the DNA unwinding activity of BLM(Bloom’s syndrome protein) with antitumor activity. ML216 inhibits helicases with IC50 of 0.97 μM and 2.98 μM for BLM636-1298 and BLMfull-length, respectively. |
| S8695 | ML221 | ML221 is a potent apelin receptor (APJ) functional antagonist in cell-based assays that is >37-fold selective over the closely related angiotensin II type 1 (AT1) receptor. The IC50 values of ML221 are 0.70 and 1.75 μM in a cAMP assay and β-arrestin assay, respectively. |
| S0150 | ML239 | ML239 is a potent and selective inhibitor of breast cancer stem cells, with an IC50 of 1.16 μM, with ~24-fold selectivity against the control cell line. |
| S0220 | ML240 | ML240 is an ATP-competitive inhibitor of p97 ATPase with an IC50 of 0.11 μM and a Ki of 0.22 μM. |
| S0219 | ML241 hydrochloride | ML241 hydrochloride is a potent and selective inhibitor of p97 with IC50 of 0.11 μM and 3.5 μM for p97 ATPase and UbG76V–GFP, respectively. |
| S8196 | ML264 | ML264 (CID-51003603), a selectively inhibitor of kruppel-like factor 5 (KLF5),potently Inhibits Growth of Colorectal Cancer. |
| S0050 | ML277 | ML277 (CID-53347902) is a potent activator of KCNQ1 channels with an EC50 of 260 nM and shows >100-fold selectivity over KCNQ2 and KCNQ4. |
| S0431 | ML281 | ML281 is a potent and selective inhibitor of Serine/threonine kinase 33 (STK33) with IC50 of 0.014 μM. ML281 is selectively toxic to KRAS-dependent cancer cell lines. |
| S7296 | ML324 | ML324 is a selective inhibitor of jumonji histone demethylase (JMJD2) with IC50 of 920 nM. |
| S0103 | ML327 | ML327 is an isoxazole compound that blocks MYC expression and tumor formation in neuroblastoma. ML327 also restores E-cadherin expression with In-Cell Western EC50 of 1.0 μM. ML327 induces apoptosis. |
| S0145 | ML329 | ML329 is an inhibitor of micropthalmia-associated transcription factor (MITF) that inhibits TRPM-1 promoter activity with IC50 of 1.2 μM. |
| S6572 | ML335 | ML335 is a potent and selective TREK-1/2 activator. ML335 is an agonist for OPRM1-OPRD1 heterdimerization with an EC50 of 403 nM, and selectivities vs. OPRM1, OPRD1, and HTR5A of 37, 2.7, and >99, respectively. |
| S6568 | ML346 | ML346 is a Hsp70 activator and a novel modulator of proteostasis for protein conformational diseases. |
| S7148 | ML347 | ML347 (LDN-193719) is a selective BMP receptor inhibitor with IC50 of 32 nM for ALK2, >300-fold selectivity over ALK3. Also inhibits ALK1 activity with IC50 of 46 nM. |
| S6564 | ML348 | ML348 (GNF-Pf-1127) is a potent and selective APT1 (Acyl protein thioesterase 1)/lysophospholipase 1 (LYPLA1) inhibitor with Ki values of 280 nM and >10 μM for APT1 and APT2, respectively. |
| S3490 | ML349 | ML349 is a potent and specific inhibitor ofacyl protein thioesterase 2(APT2)/lysophospholipase 2 (LYPLA2) with a Ki of 120 nM and IC50 of 144 nM respectively. It exhibits reduction in MCF10A and Snail cell proliferation. |
| S3387 | ML351 | ML351 is a selective inhibitor of 15-Lipoxygenase-1 (15-LOX-1 or 12/15-LOX) with IC50 of 200 nM. |
| S6557 | ML355 | ML355 is a potent and selective inhibitor of human 12-Lipoxygenase with an IC50 of 290 nM and shows excellent selectivity over related lipoxygenases and cyclooxygenases. |
| S2846 | ML359 | ML359 is a small molecule inhibitor of protein disulfide isomerase （PDI). |
| S6748 | ML364 | ML364 is a small molecule inhibitor of the deubiquitinase USP2 with an IC50 of 1.1 μM in a biochemical assay using an internally quenched fluorescent di-ubiquitin substrate. |
| S6554 | ML365 | ML365 is a novel selective small molecule inhibitor of the TASK1 or potassium channel, subfamily K, member 9 (KCNK3). |
| S0161 | ML367 | ML367 is a potent, micromolar inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization. ML367 blocks DNA repair pathways and general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation. |
| S8790 | ML385 | ML385 is a novel and specific NRF2 inhibitor with an IC50 of 1.9 μM. It inhibits the downstream target gene expression of NRF2. NRF2 regulates the activity of several ferroptosis and lipid peroxidation-related proteins. |
| E0106 | ML401 | ML401, a potent chemical probe, selectively antagonizes G-protein coupled receptor 183 (GPR183, EBI2) with an IC50 of 1.03 nM, and displays activity in a chemotaxis assay with IC50 of 6.24 nM. |
| S0715 | ML406 | ML406 is a small molecule probe that shows anti-tubercular activity via M.tuberculosis BioA (DAPA synthase) enzyme inhibition with an IC50 of 30 nM. |
| S8697 | ML792 | ML-792 is a potent and selective inhibitor of SUMO (small ubiquitin-like modifier)-activating enzyme (SAE). ML-792 inhibits SAE/SUMO1 and SAE/SUMO2 in ATP–inorganic pyrophosphate (PPi) exchange assays with IC50 of 3 nM and 11 nM, respectively. |
| A5603 | MLH1 Rabbit Recombinant mAb | MLH1 Rabbit Recombinant mAb detects endogenous level of total MLH1. |
| S9694 | MLi-2 | MLi-2 is an orally active and highly selective inhibitor of LRRK2. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro with IC50 of 0.76 nM, a cellular assay monitoring dephosphorylation of LRRK2 pSer935 LRRK2 with IC50 of 1.4 nM, and a radioligand competition binding assay with IC50 of 3.4 nM. |
| A5235 | MLKL Rabbit Recombinant mAb | MLKL Rabbit Recombinant mAb detects endogenous level of MLKL. |
| S8940 | MLN-4760 | MLN-4760 (compound 16) is a potent and selective inhibitor of human angiotensin-converting enzyme 2 (ACE2) with IC50 of 0.44 nM. MLN-4760 also inhibits bovine carboxypeptidase A (CPDA) with IC50 of 27 μM. |
| S7736 | MLN120B | MLN120B (ML120B) is a potent, selective, reversible, and ATP-competitive inhibitor of IkappaB kinase beta (IKKβ) with an IC50 of 45 nM for recombinant IKKβ. MLN120B does not inhibit other IKK isoforms at IC50 below 50 μM. |
| S1100 | MLN8054 | MLN8054 is a potent and selective inhibitor of Aurora A with IC50 of 4 nM in Sf9 insect cell. It is more than 40-fold selective for Aurora A than Aurora B. Phase 1. |
| S5996 | MLS-573151 | MLS-573151 is a selective cell division cycle 42 (Cdc42) inhibitor with an EC50 of 2 μM, which acts by blocking the binding of GTP to Cdc42. |
| S0890 | MLS000532223 | MLS000532223 is a high affinity, selective inhibitor of Rho family GTPases with EC50 ranging from 16 μM to 120 μM. |
| S8898 | MLT-748 | MLT-748 is a potent, selective and allosteric inhibitor of MALT1 with IC50 of 5 nM, binding at the interface between the caspase and immunoglobulin (Ig3) domains by displacing Trp580 and locking the catalytic site in an inactive state. |
| S7265 | MM-102 | MM-102 (HMTase Inhibitor IX) is a high-affinity peptidomimetic inhibitor of the WDR5/MLL1 protein-protein interaction, which bind to WDR5 with Ki < 1 nM and IC50 =2.4nM. |
| E1074 | MM3122 | MM3122 is a selective inhibitor of host cell serine protease TMPRSS2 (transmembrane protease serine 2) with IC50 of 0.34 nM against recombinant full-length TMPRSS2 protein. |
| S7721 | MMAE (Monomethyl auristatin E) | MMAE (Monomethyl auristatin E) is a synthetic antineoplastic agent. It is also a microtubule-disrupting agent . |
| S0328 | MMAF | MMAF (Monomethylauristatin F) is a synthetic antineoplastic agent and a potent inhibitor of tubulin polymerization. MMAF (Monomethylauristatin F) is applied as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin, ABT-414 and SGN-CD19A. |
| S0769 | MMP-9-IN-1 | MMP-9-IN-1 (OUN87710) is a specific inhibitor of matrix metalloproteinase-9 (MMP-9). MMP-9-IN-1 selectively targets the hemopexin (PEX) domain of MMP-9 with Kd of 2.1 μM. |
| A5657 | MMP11 Rabbit Recombinant mAb | MMP11 Rabbit Recombinant mAb detects endogenous level of total MMP11. |
| A5753 | MMP13 Rabbit Recombinant mAb | MMP13 Rabbit Recombinant mAb detects endogenous levels of total MMP13. |
| A5610 | MMP14 Rabbit Recombinant mAb | MMP14 Rabbit Recombinant mAb detects endogenous level of total MMP14. |
| A5620 | MMP14 Rabbit Recombinant mAb | MMP1 Rabbit Recombinant mAb detects endogenous level of total MMP1. |
| A5644 | MMP8 Rabbit Recombinant mAb | MMP8 Rabbit Recombinant mAb detects endogenous level of total MMP8. |
| A5725 | MMP9 Rabbit Recombinant mAb | MMP9 Rabbit Recombinant mAb detects endogenous levels of total MMP9. |
| E1537 | MMRi62 | MMRi62 is a ferroptosis inducer, targeting MDM2-MDM4 with Kd value of 1.39 μM. It exhibits a P53-independent pro-apoptotic activity against pancreatic ductal adenocarcinoma (PDAC) cells and induce autophagy. |
| S6739 | MN 64 | MN-64 is a potent inhibitor of TNKS1 and TNKS2 with IC50 value of 6 and 72 nM, respectively. |
| E0780 | MNITMT | MNITMT is a more potent immunosuppressive agent without bone marrow toxicity. |
| S4921 | MNS (3,4-Methylenedioxy-β-nitrostyrene) | MNS is a tyrosine kinase inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively. |
| S6813 | Mobocertinib (TAK788) | Mobocertinib (TAK788, AP32788), an investigational TKI, is a potent, selective preclinical inhibitor of epidermal growth factor receptor (EGFR) and HER2 mutations. Mobocertinib (TAK788) is an antineoplastic agent. |
| S1122 | Mocetinostat (MGCD0103) | Mocetinostat (MGCD0103, MG0103) is a potent HDAC inhibitor with most potency for HDAC1 with IC50 of 0.15 μM in a cell-free assay, 2- to 10- fold selectivity against HDAC2, 3, and 11, and no activity to HDAC4, 5, 6, 7, and 8. Mocetinostat (MGCD0103) induces apoptosis and autophagy. Phase 2. |
| S3212 | Moclobemide (Ro 111163) | Moclobemide is a MAO-A (5-HT) inhibitor with IC50 of 6.1 μM. |
| A5744 | Moesin Rabbit Recombinant mAb | Moesin Rabbit Recombinant mAb detects endogenous levels of total Moesin. |
| S2079 | Moexipril HCl | Moexipril HCl (RS-10085) is a potent orally active nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor, used for the treatment of hypertension and congestive heart failure. |
| S3104 | Moguisteine | Moguisteine(BBR-2173) is a novel peripheral non-narcotic antitussive drug. |
| S7189 | Molibresib (I-BET-762) | Molibresib (I-BET-762, GSK525762, GSK525762A) is an inhibitor for BET proteins with IC50 of ~35 nM in a cell-free assay, suppresses the production of proinflammatory proteins by macrophages and blocks acute inflammation, highly selective over other bromodomain-containing proteins. |
| S8138 | Molidustat (BAY 85-3934) | Molidustat (BAY 85-3934) is a potent hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor with IC50 of 480 nM, 280 nM, and 450 nM for PHD1, PHD2, and PHD, respectively. Phase 2. |
| S5481 | Molindone hydrochloride | Molindone hydrochloride is the hydrochloride salt form of molindone, a conventional antipsychotic used in the therapy of schizophrenia. It is a dopamine D2/D5 receptor antagonist. |
| S8969 | Molnupiravir (EIDD-2801) | Molnupiravir (EIDD-2801, MK-4482) is an orally bioavailable prodrug of the ribonucleoside analog β-d-N4-hydroxycytidine (NHC; EIDD-1931) with broad-spectrum antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV, and the causative agent of COVID-19. |
| S4664 | Molsidomine | Molsidomine (SIN-10, Corvaton, Morsydomine) is an orally active, long acting vasodilating drug. Molsidomine is metabolized in the liver to the active metabolite linsidomine. Linsidomine is an unstable compound that releases nitric oxide (NO) upon decay as the actual vasodilating compound. |
| S2219 | Momelotinib (CYT387) | Momelotinib (CYT387, LM-1149 , CYT11387) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, ~10-fold selectivity versus JAK3. Momelotinib (CYT387) induces apoptosis and autophagy. Phase 3. |
| S1987 | Mometasone furoate | Mometasone Furoate (SCH-32088,mometasone 17-furoate) is a glucocorticoid receptor agonist, used topically to reduce inflammation of the skin or in the airways. |
| E0193 | Mometasone Furoate Hydrate | Mometasone Furoate (SCH 32088) Hydrate is a synthetic glucocorticoid with anti-inflammatory activity. |
| E2933 | MOMIPP | MOMIPP, a macropinocytosis inducer, is a PIKfyve inhibitor. MOMIPP readily penetrates the blood-brain barrier and is moderately effective in suppressing progression of intracerebral glioblastoma xenografts. |
| E3438 | Momordica grosvenori Extract | Momordica Grosvenori Extract is extracted from Siraitia grosvenorii, which has antidiabetic effects by upregulating HO-1 and can be used for the treatment of diabetes. |
| E3497 | Momordicae Semen Extract | Momordicae Semen Extract is extracted from Momordicae semen, which has anti-gastritis and wound healing effects. |
| S9159 | momordin-Ic | Momordin Ic, a natural triterpenoid saponin, is a novel SENP1 (SUMO-specific protease 1) inhibitor that inhibited proliferation of prostate cancer cells in vitro and in vivo. |
| A2053 | Monalizumab (Anti-Human CD159a) | Monalizumab (Anti-Human CD159a) is a novel, first-in-class humanized immunoglobulin G4 monoclonal antibody immune checkpoint inhibitor that targets the inhibitory CD94/NKG2A receptors. |
| S8439 | Monastrol | Monastrol ((±)-Monastrol) is a cell-permeable small molecule inhibitor of kinesin-5(KIF11) with an IC50 of 14μM, which is essential for maintaining separation of the half-spindles. |
| S1652 | Monobenzone | Monobenzone(Benoquin) is a compound used as a topical agent for medical depigmentation. It can specifically block tyrosinase. |
| S5826 | Monobutyl phthalate | Monobutyl phtalate is a metabolite of di(n-butyl)phthalate. It affects the expressions of EMT-related proteins and enhances the migration and invasion of MLTC-1 cells. |
| S3499 | Monocaprylin | Monocaprylin (2,3-dihydroxypropyl octanoate, Monoctanoin, 1-Octanoyl-rac-glycerol, MC) exhibits an excellent antibacterial activity against Staphylococcus aureus and Escherichia coli. |
| S3812 | Monocrotaline | Monocrotaline (MCT, Crotaline) is an 11-membered macrocyclic pyrrolizidine alkaloid (PA) that causes a pulmonary vascular syndrome in rats characterized by proliferative pulmonary vasculitis, pulmonary hypertension, and cor pulmonale. |
| S3366 | Monoethyl malonic acid | Monoethyl malonic acid (Ethyl hydrogen malonate, Monoethyl malonate, 3-Ethoxy-3-oxopropanoic acid) is the major urinary metabolites of ethyl 3-ethoxypropionate (EEP). |
| S6889 | Monomethyl Fumarate | Monomethyl Fumarate (MMF, Monomethylfumarate, Fumaric acid monomethyl ester, Methyl hydrogen fumarate), the active metabolite of the psoriasis drug Fumaderm, is a potent GPR109A agonist. Monomethyl Fumarate prevents major dysfunctions associated with neurodegenerative diseases: oxidative stress, mitochondrial dysfunction, apoptosis and autophagy. |
| S6072 | Monomethyl glutarate | Monomethyl glutaric acid (5-Methoxy-5-oxopentanoic acid) is a dicarboxylic acid monoester and has a role as a human urinary metabolite. |
| S5829 | Monomyristin | Monomyristin (Glyceryl myristate, 2,3-Dihydroxypropyl tetradecanoate), a monoacylglyceride, shows high antibacterial and antifungal activities. |
| S5783 | Montelukast | Montelukast(MK0476) is a leukotriene receptor antagonist used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. |
| S4211 | Montelukast Sodium | Montelukast Sodium selectively antagonizes leukotriene D4 (LTD4) by binding to it so that block the action of leukotriene D4 on the cysteinyl leukotriene receptor CysLT1. Montelukast improves macroautophagy but not the chaperone-mediated autophagy pathway. Solutions are unstable and should be fresh-prepared. |
| S5747 | Morantel tartrate | Morantel (CP-12009-18, UK 296418) is a positive allosteric modulator of neuronal nicotinic acetylcholine receptors (nAChRs). |
| E3801 | Morchella Extract | Morchella Extract is drawed from Morchella esculenta, which are promising for antioxidants, immunomodulation, anti-cancer and anti-inflammatory applications. |
| S9110 | Morin | Morin (Al-Morin, Aurantica, Calico Yellow, Toxylon pomiferum), a constituent of various woods, has a role as an antioxidant, a metabolite, an antihypertensive agent, a hepatoprotective agent, a neuroprotective agent, an anti-inflammatory agent, an antineoplastic agent, an antibacterial agent, a DNA topoisomerase inhibitor and an angiogenesis modulating agent. |
| S2325 | Morin Hydrate | Morin hydrate (Aurantica) is a flavonoid isolated from Maclura pomifera (Osage orange), Maclura tinctoria (old fustic) and from leaves of Psidium guajava (common guava). |
| E3009 | Morinda Root Extract | Morinda Root Extract is extracted from Morinda officinalis How, which has anti-inflammatory and antioxidant. |
| E3402 | Moringa oleifera leaf Extract | Moringa oleifera leaf Extract is extracted from the leaves of Moringa oleifera, which has antioxidants, antibiotics, and nutrients, including vitamins and minerals. |
| E3403 | Moringa pterygosperma seed Extract | Moringa pterygosperma seed Extract is extracted from the seeds of Moringa pterygosperma, which is used in traditional medicine. |
| S2486 | Moroxydine HCl | Moroxydine HCl(ABOB hydrochloride) is a synthetic antiviral compound chemically belonging to the series of the heterocyclic biguanidines. |
| E0094 | Morphothiadin | Morphothiadin (GLS4) is a potent inhibitor on the replication of both wild-type and adefovir-resistant Hepatitis B virus (HBV) with an IC50 of 12 nM. Morphothiadin (GLS4), a nucleoside analogs that target the virus polymerase, can block the HBV replication cycle and HBV-associated chronic liver diseases. |
| S5465 | Morroniside | Morroniside, an iridoid glycoside, is the main active ingredient from Cornus officinalis Sieb. et Zucc. and Sambucus williamsii Hance. It has therapeutic effects on diabetic angiopathies, renal damage, lipid metabolism and inflammation and bone resorption. Morroniside has neuroprotective effect by inhibiting neuron apoptosis and MMP2/9 expression. |
| E3598 | Morus alba bark Extract | Morus Alba Bark Extract is extracted from the bark of Morus alba, which can regulate multiple metabolic pathways to exert hypoglycemic effects. |
| S0915 | Morusin | Morusin (Mulberrochromene) is an inhibitor of NF-κB and STAT3. Morusin is a prenylated flavonoid isolated from Marsdenia australis with antitumor, antioxidant, and anti-bacteria properties. |
| S4839 | Mosapride | Mosapride is a gastroprokinetic agent that acts as a selective 5HT4 agonist. |
| S1385 | Mosapride Citrate | Mosapride Citrate (TAK-370, AS-4370, Gasmotin) is a gastroprokinetic agent that acts as a selective 5HT4 agonist. |
| A3174 | Mosunetuzumab (Anti-CD20 & CD3e) | Mosunetuzumab (Anti-CD20 & CD3e) is expressed from CHO. The heavy chain type is IgG1, and the light chain type is hukappa. MW: 146.72 kDa. |
| S5793 | Motesanib (AMG-706) | Motesanib (AMG-706) is an orally bioavailable receptor tyrosine kinase inhibitor with IC50 values of 2 nM, 3 nM, 6 nM, 8 nM, 84 nM, 59 nM for VEGFR1, VEGFR2, VEGFR3, Kit, PDGFR and Ret, respectively. |
| S1032 | Motesanib Diphosphate (AMG-706) | Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 2 nM/3 nM/6 nM, respectively; similar activity against Kit (c-Kit), ~10-fold more selective for VEGFR than PDGFR and Ret. Phase 3. |
| S9665 | Motixafortide (BL-8040) | Motixafortide (BL-8040, BKT140, TF 14016, 4-fluorobenzoyl, 4F-benzoyl-TN14003, T140) is an antagonist of CXCR4 with IC50 of ～1 nM. BL-8040 induces the apoptosis of AML blasts by down-regulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression. |
| S7161 | Motolimod | Motolimod is a selective and potent Toll-like receptor 8 (TLR8) agonist with EC50 of 100 nM, > 50-fold selectivity over TLR7. Phase 2. |
| E2032 | MOTS-c | MOTS-c, a mitochondria-derived peptide (MDP), exerts antinociceptive and anti-inflammatory effects through activating AMPK pathway and inhibiting MAP kinases-c-fos signaling pathway. |
| B90021 | < href="/bioreagents/mouse-cd3-t-cell-isolation-kit.html">Mouse CD3+ T-Cell Isolation Kit | The Mouse CD3+ T-Cell Isolation Kit performs negative sorting by magnetic beads to isolate CD3+ T cells from single cell suspensions of mouse spleen cells or other tissues. |
| B90001 | < href="/bioreagents/mouse-cd4-t-cell-isolation-kit.html">Mouse CD4+ T-Cell Isolation Kit | |
| B90011 | < href="/bioreagents/mouse-cd8-t-cell-isolation-kit.html">Mouse CD8+ T-Cell Isolation Kit | |
| A2106 | Mouse IgG1 isotype control-InVivo | The monoclonal mouse IgG1 K immunoglobulin is ideal for use as a non-reactive isotype-matched control for mouse IgG1 antibodies in most in vivo and in vitro applications. |
| A2117 | Mouse IgG2a isotype control-InVivo | Mouse IgG2a isotype control-InVivo (Clone:C1.18.4) monoclonal antibody is ideal for use as a non-reactive isotype-matched control for mouse IgG2a antibodies in most in vivo and in vitro applications. |
| A2145 | Mouse IgG2b isotype control-InVivo | Mouse IgG2b isotype control-InVivo is ideal for use as a non-reactive isotype-matched control for mouse IgG2b antibodies in most in vivo and in vitro applications. |
| L8900 | Mouse Metabolite Compound Library | A unique collection of 158 mouse metabolites used for high throughput screening(HTS) and high content screening(HCS). |
| S3713 | Moxidectin | Moxidectin (Milbemycin B) is a potent, broad-spectrum endectocide with activity against a wide range of nematodes, insects and acari. |
| S5535 | Moxifloxacin | Moxifloxacin is an antibiotic used to treat a number of bacterial infections, active against Mycobacterium tuberculosis in vitro. |
| S1465 | Moxifloxacin (BAY12-8039) HCl | Moxifloxacin (Avelox, Avalox,BAY12-8039 HCl) is a fourth-generation synthetic fluoroquinolone antibacterial agent. |
| S5666 | Moxisylyte hydrochloride | Moxisylyte hydrochloride (thymoxamine) is an alpha-adrenergic blocking agent used for the treatment of Raynaud's disease. |
| S2066 | Moxonidine | Moxonidine (BDF5895) is a selective agonist at the imidazoline receptor subtype 1, used as antihypertensive agent. |
| S2920 | Mozavaptan | Mozavaptan (OPC-31260) is a novel competitive vasopressin receptor antagonist for both V1 and V2 receptors with IC50 of 1.2 μM and 14 nM, respectively. |
| E0482 | MP-A08 | MP-A08 is a highly selective ATP competitive sphingosine kinase (SK) inhibitor that targets both SK1 and SK2. |
| E0956 | MP07-66 | MP07-66, a FTY720 analogue, is devoid of immunosuppressive effects and shows promising antitumor effects in chronic lymphocytic leukemia by disruption of the SET-PP2A complex leading to PP2A reactivation. |
| S2567 | MPA (Medroxyprogesterone acetate) | MPA (Medroxyprogesterone acetate) is a synthetic progestin and act as a potent progesterone receptor agonist, used to treat abnormal menstruation or irregular vaginal bleeding. |
| S2809 | MPEP | MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM, exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors. |
| S7488 | MPI-0479605 | MPI-0479605 is an ATP competitive and selective inhibitor of mitotic kinase Mps1 with IC50 of 1.8 nM, >40-fold selectivity over other kinases. |
| S0316 | MPO-IN-28 | MPO-IN-28 (Compound 28) is an inhibitor of myeloperoxidase (MPO) with IC50 of 44 nM. |
| S6301 | MPP+ iodide | MPP+ iodide (N-Methyl-4-Phenylpyridinium Iodide), the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces autophagic cell death in SH-SY5Y cells. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons. |
| E1428 | Mps1-IN-6 (Compound 9) | Mps1-IN-6 (Compound 9) is a potent Mps1 inhibitor with IC50 of 6.4 nM. It also exhibits antiproliferative and anti-tumor activity in breast cancer cells. |
| S4732 | MPTP hydrochloride | MPTP hydrochloride is a dopaminergic neurotoxin and cause selective destruction of dopaminergic neurons in animal models of parkinsonism. MPTP hydrochloride induces apoptosis. |
| E0126 | MQAE | MQAE (1-(Ethoxycarbonylmethyl)-6-methoxyquinolinium bromide, N-[ethoxycarbonylmethyl]-6-methoxy-quinolinium bromide) is a 'non-ratiometric'chloride ion (Cl−)-quenched fluorescent indicator that is used to determine intracellular Cl− concentration ([Cl−] i). |
| S5819 | MRE-269 (ACT-333679) | MRE-269 (ACT-333679) is a prostaglandin I2 (IP) receptor agonist with a binding affinity for the human IP receptor that is 130-fold greater than that for other human prostanoid receptor. |
| A5294 | Mre11 Rabbit Recombinant mAb | Mre11 Rabbit Recombinant mAb detects endogenous levels of total Mre11. |
| A5791 | MRP1 Rabbit Recombinant mAb | MRP1 Rabbit Recombinant mAb detects endogenous levels of total MRP1. |
| A5785 | MRP2 Rabbit Recombinant mAb | MRP2 Rabbit Recombinant mAb detects endogenous levels of total MRP2. |
| S2855 | MRS 2578 | MRS2578 is a potent P2Y6 receptor antagonist with IC50 of 37 nM, exhibits insignificant activity at P2Y1, P2Y2, P2Y4,and P2Y11 receptors. |
| E0782 | MRT 10 | MRT-10 inhibits ShhN signaling in Shh-light2 cells in a dose-dependent manner with IC50 of 0.64 μM, showing the capacity to abrogate the constitutive activity of Smo. |
| E1427 | MRT-2359 | MRT-2359 is a potent degrader of GSPT1. It exhibits anti-tumor activity in non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) cells. |
| E0480 | MRT-81 | MRT-81 is a potent antagonist of human and rodent smoothened (Smo) receptors, with an IC50 value of 41 nM in the Shh-light2 cells, exerting potent hedgehog (Hh) signaling pathway inhibiting activity. |
| S6386 | MRT67307 | MRT67307 (IKKε/TBK1 Inhibitor II) inhibits IKKε and TBK1 with IC50 values of 160 nM and 19 nM at 0.1 mM ATP in vitro, but does not inhibit IKKα or IKKβ even at 10 μM. MRT67307 also is a highly potent ULK1 and ULK2 inhibitor with IC50s of 45 and 38 nM, respectively. MRT67307 can blocks autophagy in cells. |
| S7948 | MRT67307 HCl | MRT67307 is a potent and dual IKKϵ and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively. MRT67307 potently inhibits ULK1 and ULK2 and blocks autophagy. |
| S7949 | MRT68921 HCl | MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively. |
| S8831 | MRTX-1257 | MRTX-1257 is a potent, selective, irreversible, covalent and orally active inhibitor of KRAS G12C with IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells. |
| E1183 | MRTX0902 | MRTX0902 is a potent SOS1 inhibitor for therapeutic intervention of KRAS-driven cancers with an IC50 of 46 nM. |
| E1051 | MRTX1133 | MRTX1133 is a highly selective inhibitor of mutant KRAS G12D and can reversibly binds to the activated and inactivated KRAS G12D mutants and inhibit their activity. The specificity of MRTX1133 to KRAS G12D is more than 1000 times that of wild-type KRAS. |
| E1024 | MRTX1719 | MRTX1719 is a potent, selective inhibitor of the protein arginine methyltransferase 5·methylthioadenosine phosphorylase complex (PRMT5•MTA), a potentially tumor-selective target for therapeutic intervention. |
| S6839 | MRX-2843 | MRX-2843 (UNC2371) is an orally active dual inhibitor of tyrosine kinases MERTK and FLT3 with IC50 of 1.3 nM and 0.64 nM, respectively. |
| E2887 | MS023 hydrochloride | MS023 hydrochloride(Compound 3) is a potent, selective and cell-active inhibitor of human type I protein arginine methyltransferases (PRMT), with IC50 values of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively. |
| S9880 | MS140 | MS140 is a specific and highly potent CDK4/6 kinase inhibitor and also a CDK4/6 degrader (PROTAC). |
| E1163 | MS177 | MS177 is an EZH2-targeting PRTOAC degrader and a potent inhibitor of enzymatic EZH2, that effectively depletes both canonical EZH2–PRC2 and noncanonical EZH2–cMyc complexes. MS177 induces leukemia cell growth inhibition, apoptosis, and cell cycle progression arrest. |
| S8918 | MS1943 | MS1943 is an orally bioavailable EZH2 selective degrader that effectively reduces EZH2 levels in cells with IC50 of 120 nM for inhibiting EZH2 methyltransferase activity. |
| S0072 | MS4078 | MS4078 is an inhibitor and PROTAC (degrader) of ALK. MS4078 reduces the NPM-ALK protein levels in SU-DHL-1 cells and the EML4-ALK protein levels in NCI-H2228 cells with DC50 of 11 nM and 59 nM, respectively. MS4078 induces ALK protein degradation via cereblon and proteasome dependent mechanism and potently inhibits proliferation of SU-DHL-1 cells with IC50 of 33 nM. |
| E0935 | MS7972 | MS7972 is a small molecule that blocks human p53 and CREB binding protein association. |
| S9681 | MSA-2 | MSA-2 is an orally available non-nucleotide human STING agonist with antitumor activity. |
| S6901 | MSAB | MSAB is a selective inhibitor of Wnt/β-catenin signaling that binds to β-catenin, promoting its degradation, and specifically downregulates Wnt/β-catenin target genes. MSAB shows potent anti-tumor effects. |
| S8387 | MSC2530818 | MSC2530818, a CDK8 inhibitor with the IC50 of 2.6 nM, displays excellent kinase selectivity, biochemical and cellular potency, microsomal stability, and is orally bioavailable. |
| S7453 | MSDC-0160 | MSDC-0160 (CAY10415) is a prototype mTOT-modulating insulin sensitizer being studied to treat diabetes and Alzheimer's disease. Phase 2. |
| S9951 | MSDC-0602K Potassium | MSDC-0602K is a insulin sensitizer that modulates the mitochondrial pyruvate carrier (MPC). |
| A5915 | MSH2 Rabbit Recombinant mAb | MSH2 Rabbit Recombinant mAb detects endogenous levels of total MSH2. |
| A5267 | MSH6 Rabbit Recombinant mAb | MSH6 Rabbit Recombinant mAb detects endogenous level of MSH6. |
| A5274 | MSI2 Rabbit Recombinant mAb | MSI2 Rabbit Recombinant mAb detects endogenous level of total MSI2. |
| A5903 | mSin3A Rabbit Recombinant mAb | mSin3A Rabbit Recombinant mAb detects endogenous levels of total mSin3A. |
| A5907 | MSR1 Rabbit Recombinant mAb | MSR1 Rabbit Recombinant mAb detects endogenous levels of total MSR1. |
| E1739 | MST-312 | MST-312(Telomerase Inhibitor IX) is an inhibitor of telomerase. MST-312 is a chemically modified derivative of green tea epigallocatechin gallate (EGCG). MST-312 exhibits high chemical stability, lowers the effective dose in the induction of telomere shortening, and lowers drug resistance. MST-312 can be used for the research of cancer. MST-312 can also be used as a promising strategy in the treatment of multiple myeloma (MM). |
| E1468 | MSU-42011 | MSU-42011 is an orally active agonist of retinoid X receptor (RXR). MSU-42011 inhibits the expression of iNOS and p-ERK protein. It exhibits immunomodulatory and antitumor activity. MSU-42011 can be used for cancer research. |
| S6617 | MSX-122 | MSX-122 (Q-122) is a novel small molecule and partial CXCR4 antagonist (IC50~10 nM). |
| S0292 | MSX-127 | MSX-127 (NSC-23026) is a C-X-C chemokine receptor type 4 (CXCR4) receptor antagonist. |
| S0293 | MSX-130 | MSX-130 is an antagonist of C-X-C chemokine receptor type 4 (CXCR4). |
| S6966 | MT-802 | MT-802 is a potent PROTAC that induces Bruton's tyrosine kinase (BTK) knockdown. MT-802 recruits BTK to the cereblon E3 ubiquitin ligase complex to trigger BTK ubiquitination and degradation via the proteasome. MT-802 has potential for treatment of C481S mutant chronic lymphocytic leukemia (CLL). |
| A5402 | MTA2 Rabbit Recombinant mAb | MTA2 Rabbit Recombinant mAb detects endogenous level of total MTA2. |
| E1211 | MTB-9655 | MTB-9655 is a novel, potent and selective Acetyl-Coenzyme A Synthetase 2 (ACSS2) inhibitor, which is currently in Phase I clinical investigation on patients with tumors with high levels of ACSS2. |
| A5441 | MTCO2 Rabbit Recombinant mAb | MTCO2 Rabbit Recombinant mAb detects endogenous level of total MTCO2. |
| E0115 | MTI-31 | MTI-31 (LXI-15029) is a novel mTORC1/mTORC2 inhibitor with Kd of 0.2 nM in mTOR binding assays and displays >5,000-fold selectivity over PIK3CA, PIK3CB and PIK3G. |
| S0179 | mTOR inhibitor-1 | mTOR inhibitor-1 is a novel mTOR pathway inhibitor which can suppress cells proliferation and inducing autophagy. |
| A5866 | mTOR Rabbit Recombinant mAb | mTOR Rabbit Recombinant mAb detects endogenous levels of total mTOR. |
| S6541 | MTX-211 | MTX-211 is a first-in-class dual inhibitor of PI3K and EGFR kinase. |
| S2216 | Mubritinib (TAK 165) | Mubritinib (TAK-165) is a potent inhibitor of HER2/ErbB2 with IC50 of 6 nM in BT-474 cell; no activity to EGFR, FGFR, PDGFR, JAK1, Src and Blk in BT-474 cell line. |
| A5076 | MUC1 Rabbit Recombinant mAb | MUC1 Rabbit Recombinant mAb detects endogenous levels of MUC1. |
| A5096 | MUC4 Rabbit Recombinant mAb | MUC4 Rabbit Recombinant mAb detects endogenous levels of total MUC4. |
| S3964 | Mucic Acid | Mucic Acid (Schleimsaure, Saccharolactic acid, Tetrahydroxyadipic acid, D-Glucaric acid, Galactaric acid) is the dicarboxylic sugar acid resulting from oxidation glactose with dilute nitric acid. It is a substrate of galactarate O-hydroxycinnamoyltransferase. |
| S9075 | Mulberroside A | Mulberroside A, isolated from the ethanol extract of Morus alba roots, is widely employed as an active ingredient in cosmetic products due to its anti-tyrosinase and anti-oxidant activities. Mulberroside A decreases the expressions of TNF-α, IL-1β and IL-6 and inhibits the activation of NALP3, caspase-1 and NF-κB and the phosphorylation of ERK, JNK and p38. |
| E3600 | Mulberry Extract | Mulberry Extract is extracted from the fruit of Morus alba, which can regulate multiple metabolic pathways to exert hypoglycemic effects. |
| E3601 | Mulberry Extract (leaves) | Mulberry Extract (leaves) is extracted from Mulberry (Morus alba L.) leaves , which are traditional Chinese herbs. Mulberry leaves exert several biological functions, such as antioxidant, anti-inflammation, antidiabetic, and antitumor. |
| E3451 | Mung bean peel Extract | Mung Bean Peel Extract is extracted from the peel of Vigna radiata, which has antioxidant properties. |
| S4297 | Mupirocin | Mupirocin(BRL-4910A,Pseudomonic acid) is an isoleucyl t-RNA synthetase inhibitor, used in the treatment of bacterial skin infections. |
| S5070 | Mupirocin calcium | Mupirocin Calcium (Pseudomonic acid A) is the calcium salt form of mupirocin, a natural crotonic acid derivative extracted from Pseudomonas fluorescens,which inhibits bacterial protein synthesis and is used as an antibiotic. |
| S9709 | Muramyl dipeptide (MDP) | Muramyl dipeptide (MDP) is a shared structural unit of peptidoglycans. Muramyl dipeptide is an inducer of bone formation through the induction of Runx2. |
| E0071 | MuRF1-IN-1 | MuRF1-IN-1 is a muscle ring finger protein-1 (MuRF1) inhibitor that attenuates skeletal muscle atrophy and dysfunction in cardiac cachexia. |
| A5257 | Musashi 1 Rabbit Recombinant mAb | Musashi 1 Rabbit Recombinant mAb detects endogenous level of total Musashi 1. |
| S3871 | Muscone | Muscone (3-Methylcyclopentadecanone, Methylexaltone), a flavouring ingredient, is an organic compound that is the primary contributor to the odor of musk and also a potent anti-inflammatory agent. Muscone significantly downregulats the levels of LPS-induced inflammatory cytokines and inhibits NF-κB and NLRP3 inflammasome activation in BMDMs. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6). |
| E3347 | Mustard Extract | Mustard Extract is extracted from Brassica juncea, which helps relieve stress and depression. |
| A5857 | Mutant p53 Rabbit Recombinant mAb | Mutant p53 Rabbit Recombinant mAb detects endogenous levels of total Mutant p53. |
| E2251 | Mutated EGFR-IN-1 | Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant and T790M resistance mutant. |
| E1691 | Muvalaplin(LY3473329) | Muvalaplin(LY3473329) is an orally administered small molecule that inhibits lipoprotein (a) (Lp (a)) formation by blocking the apo(a)-apo B100 interaction. It can be used in research of atherosclerotic disease and aortic stenosis. |
| E1636 | MV1035 | MV1035, an inhibitor of ALKBH5 significantly reduces GBM U87-MG cell migration and invasiveness through inhibition of the RNA demethylase ALKBH5. |
| A5824 | MVP Rabbit Recombinant mAb | MVP Rabbit Recombinant mAb detects endogenous levels of total MVP |
| A5821 | MYBBP1A Rabbit Recombinant mAb | MYBBP1A Rabbit Recombinant mAb detects endogenous levels of total MYBBP1A |
| S8905 | MYCi361 | MYCi361 is a MYC inhibitor that engages MYC inside cells, disrupts MYC/MAX dimers, and impairs MYC-driven gene expression. MYCi361 binds to MYC with Kd of 3.2 μM. MYCi361 suppresses in vivo tumor growth, increases tumor immune cell infiltration, upregulates PD-L1 on tumors, and sensitizes tumors to anti-PD1 immunotherapy. |
| S8906 | MYCi975 | MYCi975 (NUCC-0200975) is a potent, selective and orally active inhibitor of MYC that disrupts MYC/MAX interaction, promotes MYC T58 phosphorylation and MYC degradation, and impairs MYC driven gene expression. MYCi975 exhibits potent anti-tumor activities. |
| S5704 | Myclobutanil | Myclobutanil is a widely used triazole fungicide and also a steroid demethylation inhibitor. |
| S0987 | MYCMI-6 | MYCMI-6 (NSC354961) is a potent and selective endogenous inhibitor of MYC:MAX protein interactions. MYCMI-6 blocks MYC-driven transcription and binds to the MYC bHLHZip domain with Kd of 1.6 μM. MYCMI-6 inhibits tumor cell growth in a MYC-dependent manner with IC50 of <0.5 μM. MYCMI-6 induces apoptosis. |
| S1501 | Mycophenolate mofetil | Mycophenolate mofetil is a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase I/II with IC50 of 39 nM and 27 nM, respectively. Mycophenolate Mofetil induces caspase-dependent apoptosis and cell cycle inhibition in multiple myeloma cells. |
| S2487 | Mycophenolic acid | Mycophenolic acid (Mycophenolate, RS-61443) is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive drug, used to prevent rejection in organ transplantation. |
| S0249 | Mycro 3 | Mycro 3 is a potent and selective inhibitor of c-Myc in whole cell assays. Mycro 3 also shows weak inhibitory activity against AP-1. |
| A5440 | MyD88 Rabbit Recombinant mAb | MyD88 Rabbit Recombinant mAb detects endogenous level of total MyD88. |
| P1204 | Myelin Oligodendrocyte Glycoprotein 35-55, mouse, rat | Myelin Oligodendrocyte Glycoprotein 35-55, mouse, rat (MOG 35-55) is a minor component of CNS myelin that induces experimental autoimmune encephalomyelitis in C57BL/6 mice by an encephalitogenic T cell response. |
| A5914 | Myelin oligodendrocyte glycoprotein Rabbit Recombinant mAb | Myelin oligodendrocyte Rabbit Recombinant mAb detects endogenous levels of total Myelin oligodendrocyte. |
| S8950 | MYF-01-37 | MYF-01-37 is a novel covalent inhibitor of TEAD targeting Cys380 when incubated with the TEAD2 protein. |
| S9885 | MYLS22 | MYLS22 is a first-in-class and selective inhibitor of optic atrophy 1 (OPA1) with anti-angiogenesis and anti-cancer activity. |
| A5766 | MyoD1 Rabbit Recombinant mAb | MyoD1 Rabbit Recombinant mAb detects endogenous levels of total MyoD1. |
| A5741 | Myoglobin Rabbit Recombinant mAb | Myoglobin Rabbit Recombinant mAb detects endogenous levels of total Myoglobin. |
| S0510 | Myoseverin | Myoseverin is a microtubule-binding trisubstituted purine, reversibly altering cellular function, directly binds tubulin and disrupts the structure of the microtubule cytoskeleton resulting in myotube fission at 20 μM. |
| A5558 | Myosin heavy chain Rabbit Recombinant mAb | Myosin heavy chain Rabbit Recombinant mAb detects endogenous level of total Myosin heavy chain. |
| A5655 | Myosin Light Chain 2 Rabbit Recombinant mAb | Myosin Light Chain 2 Rabbit Recombinant mAb detects endogenous level of total Myosin Light Chain 2. |
| A5430 | Myosin light chain kinase Rabbit Recombinant mAb | Myosin light chain kinase Rabbit Recombinant mAb detects endogenous level of total myosin light chain kinase. |
| S3311 | Myosmine | Myosmine is not only one of the minor tobacco alkaloids but is also present in various foods. Myosmine has low affinity against a4b2 nicotinic acetylcholinergic receptors (nAChR) with Ki of 3300 nM. |
| S2326 | Myricetin | Myricetin, a natural flavonoid with antioxidant and anti tumor properties, is a novel inhibitor of MEK1 activity and transformation of JB6 P+ mouse epidermal cells. It also inhibits PI3Kγ with Kd of 0.17 μM. |
| S2327 | Myricitrin | Myricitrin (Myricitrine), a flavonoid compound isolated from the root bark of Myrica cerifera, which exerts antinociceptive effects. |
| S3261 | Myrislignan | Myrislignan, a lignan isolated from Myristica fragrans Houtt, possesses anti-inflammatory activities. Myrislignan inhibits interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α). Myrislignan significantly inhibits the expressions of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) dose-dependently in LPS-stimulated macrophage cells. Myrislignan inhibits the NF-κB signalling pathway activation. |
| S5617 | Myristic Acid | Myristic acid (Tetradecanoic acid) is a fatty acid that occurs naturally in some foods. Myristic acid inhibits the phosphorylation of poly E4Y by Src with an Ki of 35 μM. |
| E3586 | Myristica fragrans Extract | Myristica Fragrans Extract is extracted from Myristica Fragrans, which has autophagy modulating activity. |
| S3291 | Myristicin | Myristicin (Myristicine), a terpene-like active component in Nutmeg which is the seed of Myristica fragrans, is a weak inhibitor of monamine oxidase (MAO) and a mechanism-based inhibitor of CYP1A2. |
| E3476 | Myrrh Extract | Myrrh Extract is extracted from Commiphora myrrha, which is used in the therapy of inflammatory bowel diseases. |
| S8889 | MZ-1 | MZ-1 is a PROTAC degrader of bromodomain-containing protein 4 (BRD4). MZ-1 binds to the Brd bromodomain with Kd of 62 nM, 60 nM, 21 nM, 13 nM, 39 nM and 15 nM for Brd2BD1, Brd2BD2, Brd3BD1, Brd3BD2, Brd4BD1 and Brd4BD2. |
| S0939 | γ-Mangostin | γ-Mangostin (Gamma-Mangostin) is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptors antagonist, which can reduce the perfusion pressure response of rat coronary artery to 5-HT2A with an IC50 of 0.32 µM and inhibit [3H] spiperone binding to cultured rat aortic myocytes with an IC50 of 3.5 nM. Gamma-Mangostin is also an inhibitor of Transthyretin (TTR) fibrillization. |
