所有产品
| 目录号 | 产品名 | 产品描述 |
|---|---|---|
| S6348 | (+)-Delta-Tocopherol | (+)-Delta-Tocopherol (8-Methyltocol) is the orally bioavailable delta form of the naturally-occurring fat-soluble vitamin E, mostly found in soybean and corn oils, with potential antioxidant activity. |
| S2876 | (+)-Dizocilpine (MK 801) Maleate | (+)-Dizocilpine (MK 801) Maleate is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes. |
| S2857 | (-)-Dizocilpine (MK 801) Maleate | (-)-Dizocilpine (MK 801, Dizocilpine, C13737) Maleate is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM. |
| S5643 | 1,2-dipalmitoyl-sn-glycero-3-phosphocholine | 1,2-dipalmitoyl-sn-glycero-3-phosphocholine is a zwitterionic phosphoglyceride that can be used for the preparation of liposomal monolayers. |
| S9512 | 1,3-Dicaffeoylquinic acid | 1,3-Dicaffeoylquinic acid (Cynarin; Cinarine; 1,5-Dicaffeoylquinic acid) is a phenolic compound found in artichoke. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent. |
| S6050 | 1,3-Dimethyluracil | 1,3-Dimethyluracil (N,N'-dimethyluracil) is a methyl derivative of uric acid, found occasionally in human urine. |
| S5344 | 1,4-Diaminobutane dihydrochloride | 1,4-Diaminobutane (Putrescine, Tetramethylenediamine, 1,4-Butanediamine) is used as a precursor in many biological systems and synthon for amido-ureas. |
| S6300 | 1,4-Dichlorobenzene | 1,4-Dichlorobenzene (p-Dichlorobenzene, para-dichlorobenzene) is used as a disinfectant, pesticide, and deodorant. |
| S6357 | 1,5-Diaminopentane dihydrochloride | 1,5-Diaminopentane (Cadaverine) is a foul-smelling diamine formed by bacterial decarboxylation of lysine that occurs during protein hydrolysis during putrefaction of animal tissue. |
| S3839 | 1-Deoxynojirimycin | 1-Deoxynojirimycin (duvoglustat, moranolin) is a potent α-glucosidase inhibitor and most commonly found in mulberry leaves. It has therapeutic potency against diabetes mellitus. |
| S0563 | 10-Deacetyl-7-xylosyl paclitaxel | 10-Deacetyl-7-xylosyl paclitaxel (10-Deacetyl-7-xylosyltaxol, 7-xylosyl-10-deacetylpaclitaxel), a derivative of paclitaxel and naturally occurring xyloside isolated from Taxus chinensis, causes significant mitotic arrest in PC-3 cells followed by up-regulating expression of pro-apoptotic Bax and Bad protein, as well as down-regulating expression of anti-apoptotic Bcl-2 and Bcl-XL , which leads to a disturbance of the mitochondrial membrane permeability and to the activation of caspase-9. |
| S3933 | 10-deacetyl-paclitaxel | 10-deacetyl-paclitaxel (10-DAT, Deacetyl Paclitaxel) is a semi-synthetic precursor of Paclitaxel. |
| S2409 | 10-Deacetylbaccatin-III | 10-Deacetylbaccatin-III(10-DB III) is an antineoplastic agent and an anti-cancer intermediate. |
| E0233 | 14-Deoxy-11,12-didehydroandrographolide | 14-Deoxy-11,12-didehydroandrographolide (deAND), a diterpenoid in Andrographis paniculata (Burm. f.) Nees with hypotensive, anti-inflammatory, anti-asthma, and anti-cancer activities. |
| S6140 | 16-Dehydroprogesterone | 16-Dehydroprogesterone is a chemical derived from a progesterone. |
| S5979 | 2',3'-Dideoxyadenosine | 2',3'-Dideoxyadenosine (ddA, ddAdo) is an anti-human immunodeficiency virus agent against human immunodeficiency virus (HIV) and human hepatitis B virus (HBV) replication. |
| S9374 | 2',5'-Dihydroxyacetophenone | 2',5'-Dihydroxyacetophenone (DHAP, 2-Acetylhydroquinone, Quinacetophenone) is a mixture of dihydroxyacetophenone isomers is used in food flavouring. 2',5'-Dihydroxyacetophenone significantly inhibits NO production via the suppression of iNOS expression. 2',5'-Dihydroxyacetophenone significantly decreases levels of the pro-inflammatory cytokines TNF-α and IL-6 by blocking the ERK1/2 and NF-κB signaling pathways. |
| S2477 | 2'-Deoxy-5-Fluorocytidine | 2'-Deoxy-5-fluorocytidine (5-fluoro-2(')-deoxycytidine, FCdR), a pyrimidine analog, is a DNA methyltransferase (DMNT) inhibitor currently in clinical trials for solid tumors. |
| S3248 | 2'-Deoxyadenosine 5'-monophosphate | 2'-Deoxyadenosine 5'-monophosphate (5'-dAMP), an endogenous metabolite, is only photosensitized degraded under acidic conditions. |
| S9351 | 2'-Deoxyadenosine monohydrate | 2'-Deoxyadenosine may be used as an energy source under energy stress conditions and to affect cAMP levels. |
| S3268 | 2'-Deoxycytidine 5'-monophosphate | 2'-Deoxycytidine-5'-monophosphoric acid (dCMP) is an endogenous metabolite that can be used as a model to describe mechanisms of DNA-strand breaks induced by secondary electrons and decomposes primarily by dissociation of the C-O phosphoester bond. |
| S9007 | 2'-Deoxyguanosine monohydrate | 2'-Deoxyguanosine monohydrate is a kind of purine nucleoside. |
| S3757 | 2'-Deoxyinosine | 2’-Deoxyinosine (Guanine deoxyriboside, Deoxyinosine) is the nucleoside form of hypoxanthine. It is a product of DNA damage that is formed from 2’-deoxyadenosine by adenosine deaminase or reactive nitrogen species. 2’-deoxyinosine enhances apoptosis induced by 5-fluorouracil in HT-29 and SW620 cancer cells. |
| S3169 | 2'-Deoxyuridine 5'-monophosphate disodium salt | 2'-Deoxyuridine 5'-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP). The inhibition of dUMP to dTMP at the methylation step is a key in controlling bacterial and eukaryotic cell growth. |
| E2925 | 2,2-Diphenyl-1-picrylhydrazyl | 2,2-Diphenyl-1-picrylhydrazyl (DPPH) is a stable free radical that can be used to measure the radical scavenging activity of antioxidants. The odd electron of nitrogen atom in DPPH is reduced by receiving a hydrogen atom from antioxidants to the corresponding hydrazine. |
| S4607 | 2,2′-Dihydroxy-4-methoxybenzophenone | 2,2′-Dihydroxy-4-methoxybenzophenone (Dioxybenzone, Dioxybenzon, Advastab 47, Cyasorb UV 24, Benzophenone-8) is an organic compound used in sunscreen to block UVB and short-wave UVA (ultraviolet) rays. |
| S4946 | 2,3-Dihydroxybenzoic acid | 2,3-Dihydroxybenzoic acid (Pyrocatechuic acid, 3-Hydroxysalicylic acid, Hypogallic acid) is a natural phenol found in Phyllanthus acidus and in the aquatic fern Salvinia molesta, also a product of human aspirin metabolism. It is a potentially useful iron-chelating drug and has antimicrobial properties. |
| S9355 | 2,4'-Dihydroxybenzophenone | 2,4'-Dihydroxybenzophenone (DHBP) is an organic compound used for the synthesis of pharmaceutical agents. |
| S3688 | 2,4-Diamino-6-hydroxypyrimidine | 2,4-Diamino-6-hydroxypyrimidine (DAHP) is a specific inhibitor for GTP cyclohydrolase I, the rate-limiting enzyme in de novo pterin synthesis. |
| S6067 | 2,4-dichlorobenzyl alcohol | 2,4-Dichlorobenzyl alcohol is a mild antiseptic, able to kill bacteria and viruses associated with mouth and throat infections. |
| S4762 | 2,4-Dihydroxyacetophenone | 2,4-Dihydroxyacetophenone (Resacetophenone, 4-Acetylresorcinol) is a plant metabolite that can act as a qualitative reagent for ferric iron. |
| E2903 | 2,4-dihydroxybenzaldehyde | 2,4-Dihydroxybenzaldehyde exhibits antimicrobial as well as antioxidant properties. |
| S6293 | 2,4-Dihydroxybenzoic acid | 2,4-Dihydroxybenzoic acid (β-resorcylic acid, p-Hydroxysalicylic acid) is a degradation product of cyanidin glycosides from tart cherries in cell cultures and a metabolite found in human plasma after cranberry juice consumption. |
| S3127 | 2,4-Dihydroxypyrimidine-5-carboxylic acid | 2,4-Dihydroxypyrimidine-5-carboxylic Acid (Uracil 5-carboxylic acid, Isoorotic acid, 5-Carboxyuracil) is an endogenous metabolite. |
| S6298 | 2,5-Dimethyl-2,3-dihydrofuran-3-one | 2,5-Dimethyl-2,3-dihydrofuran-3-one is a chemical. |
| S3108 | 2,5-Dimethylpyrazine | 2,5-Dimethylpyrazine (NSC 49139) is an endogenous metabolite. |
| S5169 | 2,6-Dihydroxyanthraquinone | 2,6-Dihydroxyanthraquinone (Anthraflavic acid, Anthraflavin) is a potent and specific inhibitor of cytochrome P-448 activity. |
| S6031 | 2,6-Dihydroxybenzoic acid | 2,6-Dihydroxybenzoic acid (γ-resorcylic acid, 2-Carboxyresorcinol, 2,6-Resorcylic acid) is a phenolic compound which is known to have poor biological performance such as DPPH scavenging activity and microbial growth inhibition. |
| S3693 | 2,6-Dihydroxypurine | 2,6-Dihydroxypurine (Xanthine, Isoxanthine) is a purine base found in most body tissues and fluids, certain plants, and some urinary calculi. It is a product on the pathway of purine degradation. |
| S6323 | 2,6-Dimethoxybenzoic acid | 2,6-Dimethoxybenzoic acid is a polyphenol compound found in foods of plant origin. |
| S8696 | 2-D08 | 2-D08 (2',3',4'-trihydroxy flavone) is a cell permeable, mechanistically unique inhibitor of protein sumoylation. |
| S3101 | 2-Deoxy-D-ribose | 2-Deoxy-D-ribose (Thyminose, Deoxyribose) is an endogenous metabolite. |
| S4701 | 2-DG (2-Deoxy-D-glucose) | 2-DG (2-Deoxy-D-glucose), an analog of glucose, is a glycolytic inhibitor with antiviral activity. 2-Deoxy-D-glucose induces apoptosis and inhibits Herpes Simplex Virus type-1 (HSV-1) receptor expression. |
| S0274 | 2-DI-1-ASP | 2-Di-1-ASP (DASPI, 2M2PM, D 308, Compound 18a) is a mono-stryryl dye which can be used as a mitochondrial stain and a groove-binding fluorescent probe for G-quadruplex (G4) DNA. |
| S5505 | 2’-deoxyuridine | 2'-deoxyuridine (dU, 2'-dU) is frequently halogenated to create thymidine analogues useful for studies of DNA synthesis and degradation mechanisms. |
| E2690 | 3,3'-Diaminobenzidine tetrahydrochloride | 3,3'-Diaminobenzidine tetrahydrochloride (DAB) is the most sensitive and commonly used substrate for horseradish peroxidase, which can visualize the color of cells or tissues bound by horseradish peroxidase during immunohistochemistry or in situ hybridization. |
| S4728 | 3,3'-Diindolylmethane | 3,3'-Diindolylmethane(DIM) is a major digestive product of indole-3-carbinol, a potential anticancer component of cruciferous vegetables. 3,3'-Diindolylmethane is a strong, pure androgen receptor (AR) antagonist. |
| E4432 | 3,3-Dimethyl-1-butanol | 3,3-Dimethyl-1-butanol (Neohexanol) is an orally active inhibitor of trimethylamine (TMA) and trimethylamine N-oxide (TMAO). 3,3-dimethyl-1-butanol negatively inhibits the signalling pathways of p65 NF-κB and TGF-β1/Smad3. 3,3-dimethyl-1-butanol has potential applications in cardiovascular disease (CVD). |
| S6283 | 3,3-Dimethylglutaric acid | 3,3-Dimethylglutaric acid (3,3-Dimethylpentanedioate) is a compound that has occasionally found in human urine. |
| S4622 | 3,4-Diaminopyridine | 3,4-Diaminopyridine (Amifampridine, pyridine-3,4-diamine) blocks presynaptic potassium channels, and subsequently prolongs the action potential and increases presynaptic calcium concentrations. It is a drug predominantly used in the treatment of a number of rare muscle diseases. |
| E2896 | 3,4-Dichlorophenyl isothiocyanate | 3,4-Dichlorophenyl isocyanate(1,2-Dichloro-4-isothiocyanatobenzene) is a chemical compound used as a chemical intermediate and in organic synthesis. |
| S3952 | 3,4-Dihydroxybenzaldehyde | 3,4-Dihydroxybenzaldehyde (Protocatechuic aldehyde) is a phenolic aldehyde, a precursor in vanillin synthesis via biotransformation by cell cultures of Capsicum frutescens, a type of chili pepper. |
| S6338 | 3,4-Dihydroxyhydrocinnamic acid | 3,4-Dihydroxyhydrocinnamic acid (Dihydrocaffeic acid) is a metabolite product of the hydrogenation of caffeoylquinic acids, occurring in normal human biofluids, with potent antioxidant properties. |
| S9341 | 3,4-Dimethoxycinnamic acid | 3,4-Dimethoxycinnamic acid (Caffeic acid dimethyl ether) is a bioavailable coffee component as a perspective anti-prion compound and bind potently to prion protein with a Kd of 405 nM. |
| S6160 | 3,5-Dihydroxybenzoic acid | 3,5-Dihydroxybenzoic acid (α-resorcylic acid) is a primary metabolite of alkylresinols which has been hydrolyzed by liver enzymes during phase I metabolism after several cycles of beta oxidation. |
| S6474 | 3,5-diiodo-L-thyronine (3,5-T2) | 3,5-diiodo-L-thyronine (3,5-T2, NSC 90469) is an endogenous metabolite of thyroid hormones. 3,5-Diiodo-l-thyronine has been proposed as a potential hypolipidemic agent for treatment of obesity and hepatic steatosis.The solubility of this product is not good, please choose carefully for cell experiments! |
| S3958 | 3,5-Diiodotyrosine Dihydrate | 3,5-Diiodotyrosine Dihydrate (Iodogorgoic acid, apothyrin, jodgorgon) is a product from the iodination of monoiodotyrosine. In the biosynthesis of thyroid hormones, diiodotyrosine residues are coupled with other monoiodotyrosine or diiodotyrosine residues to form T4 or T3 thyroid hormones. |
| S6071 | 3,5-Dimethoxyphenol | 3,5-Dimethoxyphenol (Phloroglucinol dimethyl ether) is a toxin metabolite that can be found in human consuming yew (Taxus baccata) leaves. |
| S9401 | 3,6'-Disinapoyl sucrose | 3,6'-Disinapoyl sucrose (Disinapoyl sucrose), an oligosaccharide ester natural product originating from the root of wild Polygala tenuifolia, has neuroprotective effects and antidepressive activity in rats. |
| S6835 | 3-deazaadenosine | 3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine hydrolase, with a Ki of 3.9 µM, and has anti-inflammatory, anti-proliferative and anti-HIV activity. |
| S0787 | 3-Deazaadenosine hydrochloride | 3-Deazaadenosine HCl (3-DZA, c3Ado) is a potent inhibitor of S-adenosylhomocysteine hydrolase with Ki of 3.9 µM. 3-Deazaadenosine HCl inhibits bacterial lipopolysaccharide-induced transcription of TNF-α and IL-1β. 3-Deazaadenosine HCl inhibits the transcriptional activity of NF-κB, prevents FCS-induced Ras carboxyl methylation and reduces FCS-induced ERK1/2 and Akt phosphorylation. 3-Deazaadenosine HCl has anti-inflammatory, anti-proliferative and anti-HIV activities. |
| S9378 | 4',5-Dihydroxyflavone | 4',5-Dihydroxyflavone inhibits soybean LOX-1 and yeast α-glucosidase. |
| S3918 | 4',7-Dimethoxy-5-Hydroxyflavone | 4',7-Dimethoxy-5-Hydroxyflavone (4',7-dimethylapigenin, apigenin dimethylether, apigenin 7,4'-dimethyl ether) inhibits α-glucosidase and α-amylase enzymes and enhances 2-NBDG uptake in L6 cells. |
| S3910 | 4',7-Dimethoxyisoflavone | 4',7-Dimethoxyisoflavone, isolated from the leaves of Albizzia lebbeck, shows antifungal activity in vitro. |
| S3908 | 4'-Demethylpodophyllotoxin | 4'-Demethylpodophyllotoxin is isolated from the herb of Dysosma pleiantha (Hance) Woodson with remarkable cytotoxic potential in diverse cancer cell lines. |
| S5437 | 4,4'-DDE | 4,4'-DDE (DDE, p,p'-DDE, p,p'-dichlorodiphenyldichloroethylene), a breakdown product of DDT, is an organochlorine pesticide and may behave as a potent androgen receptor antagonist. |
| S5310 | 4,4'-Dimethoxybenzil | 4,4'-Dimethoxybenzil (p-Anisil) is a biochemical that has been reported to have mesomorphic properties of a substituted bis(dithiolene)nickel complex derived from 4,4′-dimethoxybenzil. |
| S2254 | 4-Demethylepipodophyllotoxin(NSC-122819,VM-26) | 4-Demethylepipodophyllotoxin (NSC-122819, VM-26, DMEP) is an antimitotic agent which binds to monomeric tubulin, preventing micro-tubule polymerization. It is a potent inhibitor of microtubule assembly. |
| S5748 | 4′-Deoxyphlorizin | 4'-Deoxyphlorizin is an inhibitor of the glucose transport system. |
| E4032 | 5'-Deoxy-5'-(methylthio)adenosine | 5'-Deoxy-5'-(methylthio)adenosine (Methylthioadenosine, MTA) is a naturally occurring sulfur-containing nucleoside produced by the decarboxylation of S-adenosylmethionine. This nucleoside is a potent agonist of adenosine receptors with Ki of 0.15, 1.13, 13.9, and 0.68 μM for A1, A2A, A2B, and A3, respectively. |
| E4042 | 5,5-Dimethyl-1-pyrroline N-oxide | 5,5-Dimethyl-1-pyrroline N-oxide (DMPO) is a cell-permeable hydrophilic spin trap agent for superoxide detection. It acts as a neuroprotective agent and incubating lymphocytes with DMPO decreases DNA damage by NiCl2. |
| S4624 | 5,5-Dimethyloxazolidine-2,4-dione | 5,5-Dimethyloxazolidine-2,4-dione (Dimethadione, Dimethyloxazolidinedione, Dimethadion) is an anticonvulsant that is the active metabolite of trimethadione. |
| E2914 | 5,6-Dichlorobenzimidazole 1-beta-D-ribofuranoside | 5,6-Dichlorobenzimidazole riboside(DRB) is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II and CDKs. It trigger p53-dependent apoptosis of human colon adenocarcinoma cells without inducing genotoxic stress to healthy cells. |
| S3097 | 5,6-Dimethylbenzimidazole | 5,6-Dimethylbenzimidazole (5,6-DMB, Dimezol, Dimedazol, 5,6-Dimethyl-1H-benzo[d]imidazole, 5,6-Dimethyl-1H-benzimidazole) is a vitamin B12 precursor. |
| S9380 | 5,7-Dihydroxy-4-methylcoumarin | 5,7-Dihydroxy-4-methylcoumarin may be used for pharmaceutical synthesis. |
| E0023 | 5,7-Dihydroxychromone | 5,7-Dihydroxychromone (DHC), a natural antioxidant extracted from plants, is a potent activator of Nrf2/ARE signal. 5,7-dihydroxychromone also is a potent activator of PPARγ and LXRα. 5,7-Dihydroxychromone may contributes to regulate blood glucose levels and shows anti-diabetic property. |
| S3227 | 5,7-Dimethoxyflavone | 5,7-Dimethoxyflavone (5,7-DMF) is an inhibitor of cytochrome P450 (CYP) 3As that markedly decreases the expression of CYP3A11 and CYP3A25 in the liver. 5,7-Dimethoxyflavone (5,7-DMF) is also a potent Breast Cancer Resistance Protein (BCRP, ABCG2) inhibitor. 5,7-Dimethoxyflavone (5,7-DMF) is one of the major components of Kaempferia parviflora with anti-obesity, anti-inflammatory, and antineoplastic effects. |
| S6088 | 6-(Dimethylamino)purine | 6-Dimethylaminopurine (N,N-Dimethyladenine) is a serine threonine protein kinase inhibitor. It inhibits the germinal vesicle breakdown and the meiotic maturation of oocytes. |
| S8620 | 6-Diazo-5-oxo-L-norleucine | 6-Diazo-5-oxo-L-norleucine (Diazooxonorleucine, L-6-Diazo-5-oxonorleucine, DON), an antibiotic isolated from Streptomyces, is a glutaminase antagonist with IC50 of ~1 mM for cKGA (kidney-type glutaminase). 6-Diazo-5-oxo-L-norleucine exhibits analgesic, antibacterial, antiviral and anticancer properties. |
| E1022 | 7,12-Dimethylbenz[a]anthracene (DMBA) | 7,12-Dimethylbenz[a]anthracene (DMBA) is an immunosuppressor as well as a potent organ-specific carcinogen. |
| S9000 | 7,8-Dihydroxy-4-methylcoumarin | 7,8-Dihydroxy-4-methylcoumarin (DHMC) is a precursor in the synthesis of derivatives of 4-methyl coumarin, which has excellent radical scavenging properties. |
| S9356 | 7,8-Dihydroxy-4-phenylcoumarin | 7,8-Dihydroxy-4-phenylcoumarin is an intermediate. |
| S8319 | 7,8-Dihydroxyflavone | 7,8-Dihydroxyflavone (7,8-DHF) acts as a potent and selective small-molecule agonist of the TrkB receptor (Kd ≈ 320 nM), the main signaling receptor of brain-derived neurotrophic factor (BDNF). |
| E0834 | 7,8-Dimethoxy-4H-chromen-4-one | 7,8-Dimethoxy-4H-chromen-4-one is a bioactive compound. |
| S5308 | 7-(Diethylamino)coumarin-3-carboxylic acid | 7-(Diethylamino)-coumarin-3-carboxylic acid (7-DCCA) has been used as a laser dye, fluorescent label, and biomedical inhibitor in many different applications. |
| S5386 | 7-Dehydrocholesterol | 7-Dehydrocholesterol (7-DHC, Provitamin D3) is the direct precursor of free cholesterol in the cholesterol biosynthetic pathway in mammalian tissues and also a biosynthetic precursor to vitamin D3. |
| S4695 | D panthenol | D panthenol (Dexpanthenol, D-Panthenol, Pantothenol, Ilopan, D-Pantothenyl alcohol) is an alcoholic analogue of D-pantothenic acid and cholinergic agent. |
| S6330 | D(-)-2-Aminobutyric acid | D(-)-2-Aminobutyric acid is an unnatural amino acid serving as an important intermediate in pharmaceutical production. |
| S5134 | D(-)-Arabinose | D-Arabinose is a reducing sugar useful as a substrate in analysis of arabinose isomerases and synthesis of D-erythroascorbic acid in yeast. |
| S4704 | D-(+)-Cellobiose | D-(+)-Cellobiose (Cellobiose, Cellose, Beta-Cellobiose, D-Cellobiose) is a substrate of β-glucosidase. |
| S3310 | D-(+)-Galacturonic acid monohydrate | D-(+)-Galacturonic acid monohydrate (D-Galacturonic acid hydrate, d-GalA, D-galUA) is an endogenous metabolite that can be used in engineering Saccharomyces cerevisiae. |
| E2962 | D-(+)-Malic acid | D-(+)-Malic acid (D-Malic acid), found in apples and many other fruits and plants is an active enantiomer of Malic acid. It is a competitive inhibitor of L(-)malic acid transport. |
| S5142 | D-(+)-Melezitose | Melezitose (D-Melezitose, (+)-Melezitose, D-melicitose, (+)-melicitose, melicitose) is a nonreducing trisaccharide sugar that is produced by many plant sap eating insects. |
| S9349 | D-(+)-Raffinose pentahydrate | Raffinose is a trisaccharide composed of galactose, glucose, and fructose. |
| S9348 | D-(+)-Trehalose Anhydrous | Trehalose is a non-reducing sugar. It is thought to provide plants and animals with the ability to withstanding periods of dehydration. |
| S3992 | D-(+)-Trehalose dihydrate | Trehalose is a non-reducing sugar. It is thought to provide plants and animals with the ability to withstanding periods of dehydration. |
| S3338 | D-(-)-Lyxose | D-(-)-Lyxose (D-Lyxose) is an active endogenous metabolite. |
| S3134 | D-(-)-Tartaric acid | D-(-)-Tartaric acid is the unnatural isomer of Tartaric acid which is an important chiral chemical building block with broad industrial and scientific applications. |
| S6027 | D-(−)-Pantolactone | D-(−)-Pantolactone is the degradation product of pantothenic acid, which is a water-soluble essential vitamin. |
| S6326 | D-3-Phenyllactic acid | D-3-Phenyllactic acid is a chiral building block that is used in preparation of statine. |
| S3203 | D-Alanine | D-alanine (Ala, (R)-Alanine, Ba 2776, D-α-Alanine, NSC 158286) is an endogenous co-agonist at the glycine site of the N-methyl-d-aspartate (NMDA) receptor. |
| E1246 | D-AP5 | D-AP5 (D-APV; D-2-Amino-5-phosphonovaleric acid) is a selective and competitive NMDA receptor antagonist that inhibits the glutamate binding site of NMDA receptors. |
| S6114 | D-Arabitol | D-Arabitol is a water soluble sugar alcohol. |
| E0654 | D-Arginine | D-Arginine is an inhibitor of arginine decarboxylase(ADC) to regulate putrescine biosynthesis. |
| S5129 | D-Aspartic acid | D-Aspartic acid (D-Asp, Aminosuccinic acid, asparagic acid, asparaginic acid) is an endogenous amino acid occurring in several tissues and cells of both invertebrates and vertebrates. It can regulate testosterone synthesis and may act on a stimulatory receptor (NMDA). |
| S5874 | D-Carnitine hydrochloride | D-Carnitine hydrochloride ((S)-Carnitine hydrochloride, (+)-Carnitine hydrochloride) is biosynthesized from lysine. It might be associated with the energy production from branched chain amino acids. |
| S1998 | D-Cycloserine | D-cycloserine (RO-1-9213) is an analog of the amino acid D-alanine, used as an antibiotic in the treatment of tuberculosis. |
| E2951 | D-Desthiobiotin | D-Desthiobiotin(Dethiobiotin) is a biotin derivative used in affinity chromatography and protein chromatography. D-Desthiobiotin also can be used for protein cross-linking agent, protein and cell labeling, detection and isolation. |
| S6290 | D-Fructose-1,6-diphosphate trisodium salt octahydrate | D-Fructose-1,6-diphosphate trisodium salt octahydrate (FBP trisodium salt octahydrate), a common metabolic sugar, is the precursor of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate in the glycolytic pathway. |
| S3849 | D-Galactose | D-Galactose (D-Galactopyranose, D-(+)-Galactose) is an aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins and is converted enzymatically into D-glucose for metabolism or polysaccharides for storage. It accelerates senescence in invertebrates and mammals and has been used as a model for aging. |
| S3595 | D-Gluconic acid | D-Gluconic acid is an antifungal agent. |
| S4894 | D-Glucurone | D-Glucurone is a glucuronic acid derivative that is used for treating canine hepatitis. |
| S6343 | D-Glucuronic acid | D-Glucuronic acid (D-Glucopyranuronic Acid) is a key intermediate metabolite of the uronic acid pathway and may plays a role in the detoxification of certain drugs. |
| S3362 | D-Gulonic acid γ-lactone | D-Gulonic acid γ-lactone (Gulonolactone, D-Gulono-1,4-lactone, 1,4-D-Gulonolactone) is an active endogenous metabolite. |
| S0054 | D-I03 | D-I03 is a selective inhibitor of RAD52 with Kd of 25.8 µM. D-I03 inhibits ssDNA annealing by RAD52 and D-loop formation with IC50 of 5 µM and 8 µM, respectively. |
| P1106 | D-JNKI-1 | D-JNKI-1 (AM-111, XG-102, Brimapitide) is a highly and cell-permeable peptide inhibitor of JNK. |
| S6683 | D-Lin-MC3-DMA (MC3) | D-Lin-MC3-DMA (MC3, DLin-MC3-DMA) is a potent and ionizable cationic lipid. D-Lin-MC3-DMA is used for delivery of siRNA in vivo. |
| S7763 | D-Luciferin | D-Luciferin is a popular bioluminescent substrate of luciferase in the presence of ATP, used in luciferase-based bioluminescence imaging and cell-based high-throughput screening applications. In an immunocompetent mouse model of ovarian cancer, the use of D-luciferin substrate and firefly luciferase preserves tumour-host immune interactions since bioluminescent imaging is a more sensitive indication of tumour growth than weight gain. |
| S6580 | D-Luciferin Potassium Salt | D-luciferin is the natural substrate of the enzyme luciferase (Luc) which catalyzes the production of the typical yellow-green light of fireflies. The 560 nm chemiluminescence from this reaction peaks within seconds, with light output that is proportional to luciferase concentration when the substrate luciferin is present in excess. The luciferase (luc) gene is a popular reporter gene for research and agent screening. Chemiluminescent techniques are virtually background-free, making the luc reporter gene ideal for detecting low-level gene expression. In addition to its role as a reporter of gene expression, luciferase is commonly used in an extremely sensitive assay for ATP. |
| S6924 | D-Luciferin sodium salt | D-Luciferin (D-(-)-Luciferin, Firefly luciferin) sodium salt is the natural substrate of luciferases that catalyze the production of light in bioluminescent insects. |
| S2381 | D-Mannitol | D-Mannitol is an osmotic diuretic agent and a weak renal vasodilator. |
| S3332 | D-Mannosamine hydrochloride | D-Mannosamine hydrochloride ((2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride) is an active endogenous metabolite. |
| S5763 | D-Mannose | D-mannose is a naturally occurring simple sugar that may help your body cleanse the urinary tract and maintain a healthy bladder lining. |
| S5220 | D-Pantethine | Pantethine (Bis-pantethine, Pantetina, Pantomin, Pantosin) is a naturally occurring compound synthesized in the body from pantothenic acid (vitamin B5) via addition of cysteamine and used as a dietary supplement for lowering blood cholesterol and triglycerides. |
| S5558 | D-Pantothenate Sodium | D-Pantothenate Sodium, the sodium salt of D-pantothenate, is a derivative of vitamin B5 which is an an essential nutrient and plays important roles in the oxidation of fats and carbohydrates and certain amino acids. |
| S4153 | D-Phenylalanine | D-Phenylalanine, a carboxypeptidase A, endorphinase and enkephalinase inhibitor, enhances endorphin production and diminishes pain. |
| S3870 | D-Pinitol | D-pinitol (Methylinositol, Pinitol, 3-O-Methyl-D-chiro-inositol, D-(+)-Pinitol, Inzitol) is a naturally occurring compound derived from soy and has significant pharmacological activitites such as inhibition of the T-helpercell-1 response, antiviral, larvicidal, antiinflammatory, antihyperlipidemic, cardioprotective, inhibition of ovalbumin-induced airway inflammation and antioxidant. |
| S6016 | D-Proline | D-proline is an isomer of the naturally occurring amino acid, L-Proline. |
| S3107 | D-Pyroglutamic acid | D-Pyroglutamic acid (D-5-Oxoproline, D-Pyr-OH, 5-oxo-D-proline, (R)-5-Oxopyrrolidine-2-carboxylic acid) is an active endogenous metabolite that antagonizes the disruption of passive avoidance behaviour induced by the N-methyl-D-aspartate receptor antagonist AP-5. |
| S5544 | D-Ribose | D-ribose is a naturally occurring sugar involved in producing energy in the body and is also the structural basis of DNA and RNA. |
| E2694 | D-Saccharic acid 1,4-lactone monohydrate | D-Saccharic acid 1,4-lactone monohydrate is a potent β-glucuronidase inhibitor with an IC50 of 48.4 μM. |
| S2993 | D-Saccharic acid potassium salt | D-Saccharic acid potassium salt (D-Glucaric acid potassium, Potassium bisaccharate) is an endogenous metabolite. |
| S5387 | D-Tagatose | D-Tagatose is an isomer of fructose and is used as a sweetener in beverages, yogurt, creams, and dietetic candy. |
| S0319 | D3-βArr | D3-βArr(NCGC00379308) is a positive allosteric modulator of thyrotropin receptor (TSHR) that modulates TSH-induced β-Arr 1 translocation. |
| E1685 | D609 | D609 is a selective, competitive inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC) with a Ki of 6.4 μM. It is an antioxidative protector and has antiviral and anti-inflammatory activity and also inhibits angiogenesis by preventing the synthesis of basement membrane (BM). |
| S2196 | Dabigatran | Dabigatran is a potent nonpeptide thrombin inhibitor with an IC50 of 9.3 nM in a cell-free assay. |
| S2154 | Dabigatran (BIBR-1048) etexilate | Dabigatran Etexilate (BIBR-1048) is the prodrug of dabigatran, a potent, nonpeptidic small molecule that specifically and reversibly inhibits both free and clot-bound thrombin by binding to the active site of the thrombin molecule. |
| S5960 | Dabigatran etexilate mesylate | Dabigatran etexilate mesylate (Pradaxa, BIBR 1048MS, Dabigatran etexilate methanesulfonate) is an orally active prodrug of Dabigatran which is a reversible and selective, direct thrombin inhibitor (DTI). Dabigatran selectively and reversibly inhibits human thrombin with Ki of 4.5 nM and thrombin-induced platelet aggregation with IC50 of 10 nM. |
| S2807 | Dabrafenib | Dabrafenib is a mutant BRAFV600E specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively. |
| S5069 | Dabrafenib Mesylate | Dabrafenib Mesylate (GSK2118436) is the mesylate salt form of dabrafenib, an orally bioavailable inhibitor of B-raf (BRAF) protein with IC50s of 0.8 nM, 3.2 nM and 5 nM for B-Raf (V600E), B-Raf (WT) and C-Raf, respectively. |
| S9876 | Dac51 | Dac51 is a potent FTO inhibitor with an IC50 of 0.4 μM for inhibiting FTO demethylation. |
| S1221 | Dacarbazine | Dacarbazine is a triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis; used in the treatment of various cancers. |
| S1095 | Dacinostat (LAQ824) | Dacinostat (LAQ824, NVP-LAQ824) is a novel HDAC inhibitor with IC50 of 32 nM and is known to activate the p21 promoter. |
| S1482 | Daclatasvir (BMS-790052) | Daclatasvir (BMS-790052, EBP883) is a highly selective inhibitor of HCV NS5A with EC50 of 9-50 pM, for a broad range of HCV replicon genotypes and the JFH-1 genotype 2a infectious virus in cell culture. Phase 3. |
| S5062 | Daclatasvir Dihydrochloride | Daclatasvir is an orally available antiviral agent that inhibits the NS5A region of the hepatitis C virus (HCV) used for the treatment of chronic HCV genotype 1 and 3 infection. |
| S2727 | Dacomitinib | Dacomitinib is a potent, irreversible pan-ErbB inhibitor, mostly to EGFR with IC50 of 6 nM in a cell-free assay. Dacomitinib inhibits ERBB2 and ERBB4 with IC50 of 45.7 nM and 73.7 nM, respectively. Dacomitinib is effective against NSCLCs with EGFR or ERBB2 mutations (resistant to gefitinib) as well as those harboring the EGFR T790M mutation. Dacomitinib inhibits cell growth and induces apoptosis. Phase 2. |
| S1009 | Dactolisib (BEZ235) | Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell. Dactolisib induces autophagy and suppresses HIV-1 replication. Phase 2. |
| S1849 | Daidzein | Daidzein is a natural isoflavone phytoestrogen found in Leguminosae, used as a component of foods and dietary supplements. Daidzein is a soy isoflavone, which acts as a PPAR activator. |
| S2289 | Daidzin | Daidzin (Daidzoside, Daidzein 7-O-glucoside, Daidzein 7-glucoside), a natural organic compound in the class of phytochemicals known as isoflavones, is a potent and selective inhibitor of human mitochondrial aldehyde dehydrogenase and inhibits ALDH-I selectively (Ki=20 nM); at least 500 times less effective against ALDH-Ⅱ, the cytosolic isozyme (Ki=10 μM). |
| S4848 | Dalbavancin | Dalbavancin is a lipoglycopeptide antibiotic that has bactericidal activity against Gram-positive bacteria including various staphylococci. |
| S2772 | Dalcetrapib (JTT-705) | Dalcetrapib (JTT-705) is a rhCETP inhibitor with IC50 of 0.2 μM that increases the plasma HDL cholesterol. Phase 3. |
| S6761 | Dalfopristin | Dalfopristin (RP54476) is a semi-synthetic analogue of ostreogyrcin A. Quinupristin/dalfopristin (Q/D) is a parental streptogramin with a spectrum of activity that includes Gram-positive pathogens, including those resistant to other classes of antimicrobial compounds. |
| E0951 | Dalpiciclib | Dalpiciclib (SHR-6390), a highly selective, orally bioavailable CDK4/6 inhibitor with comparable potencies against CDK4 and CDK6, exerts potent antitumor activity in esophageal squamous cell carcinoma by inhibiting phosphorylated tumor-suppressor retinoblastoma protein (Rb) and inducing G1 cell cycle arrest. This product has poor solubility, animal experiments are available, cell experiments please choose carefully! |
| S6431 | Damascenone | Damascenone is a potent flavor compound, possessing an extremely low odor threshold of 0.002 ppb in water. |
| E3543 | Dandelion Extract | Dandelion Extract is extracted from Taraxacum, which has antioxidant and anti-inflammatory activities. |
| S9948 | Danicamtiv (MYK-491) | Danicamtiv (MYK-491, SAR 440181) is a novel cardiac myosin activator that enhances cardiomyocyte contraction. |
| S0803 | Danicopan | Danicopan is a potent, selective and orally active inhibitor of factor D with Kd of 0.54 nM for human Factor D. Danicopan inhibits alternative pathway of complement (APC) activity, and has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS). |
| S6620 | Danirixin (GSK1325756) | Danirixin (GSK1325756) is a small molecule, non-peptide, high affinity (IC50 for CXCL8 (IL-8) binding = 12.5 nM), selective, and reversible CXCR2 antagonist. |
| S3058 | Danofloxacin Mesylate | Danofloxacin (CP-76136-27) is a fluoroquinolone antibacterial for veterinary use, with MIC90 of 0.28 μM. |
| S1183 | Danoprevir | Danoprevir is a peptidomimetic inhibitor of the NS3/4A protease of hepatitis C virus (HCV) with IC50 of 0.2-3.5 nM, inhibition effect for HCV genotypes 1A/1B/4/5/6 is ~10-fold higher than 2B/3A. Phase 2. |
| S4741 | Danshensu | Danshensu (Salvianic acid A), a herbal preparation used in traditional Chinese medicine, possesses potential antitumor and anti‑angiogenesis effects. Danshensu inhibits CYP2E1 and CYP2C9 with IC50 of 36.63 and 75.76 μm, respectively. |
| E0451 | Dansylcadaverine (Monodansyl cadaverine) | Dansylcadaverine (Monodansyl cadaverine, MDC) is an autofluorescent compound used for the labeling of autophagic vacuoles. Dansylcadaverine, a high affinity substrate of transglutaminases, can block the receptor-mediated endocytosis of many ligands. |
| S4561 | Danthron | Danthron (Chrysazin, Antrapurol) functions in regulating glucose and lipid metabolism by activating AMPK. Danthron is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron used to be a laxativa and now is currently used as an antioxidant in synthetic lubricants, in the synthesis of experimental antitumor agents, as a fungicide and as an intermediate for making dyes. |
| S5478 | Dantrolene sodium | Dantrolene sodium(F 440) acts as a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors. |
| S4648 | Dantrolene sodium hemiheptahydrate | Dantrolene sodium hemiheptahydrate (Dantrium) is a skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. |
| S9851 | Danuglipron (PF-06882961) | Danuglipron (PF-06882961), a non-peptide agonist, activates the canonical G protein signaling activity only in the Glucagon-like peptide-1 (GLP-1) receptor with Trp33ECD. |
| S1107 | Danusertib (PHA-739358) | Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Danusertib induces apoptosis, cell cycle arrest, and autophagy. Phase 2. |
| A5517 | DAP Kinase 1 Rabbit Recombinant mAb | DAP Kinase 1 Rabbit Recombinant mAb detects endogenous level of total DAP Kinase 1. |
| S1548 | Dapagliflozin | Dapagliflozin is a potent and selective hSGLT2 inhibitor with EC50 of 1.1 nM, exhibiting 1200-fold selectivity over hSGLT1. Phase 4. |
| S5566 | Dapagliflozin propanediol monohydrate | Dapagliflozin propanediol belongs to the class of orally administered antidiabetic agents designated as sodiumglucose cotransporter 2 (SGLT2) inhibitors. |
| S8907 | Dapansutrile | Dapansutrile is a novel and selective NLRP3 inflammasome inhibitor. |
| E3727 | Daphne genkwa Sieb.et Zucc. Extract | Daphne Genkwa Sieb.Et Zucc. Extract is derived from the dried flowers of Daphne genkwa Sieb. et Zucc. (Thymelaeaceae), which are a Chinese herbal medicine used as an abortifacient with purgative, diuretic and anti-inflammatory activities. |
| S2554 | Daphnetin | Daphnetin, a natural coumarin derivative, is a protein kinase inhibitor, inhibits EGFR, PKA and PKC with IC50 of 7.67 μM, 9.33 μM and 25.01 μM, respectively, also known to exhibit anti-inflammatory and anti-oxidant activities. |
| E3518 | Daphniphyllum calycinum Extract | Daphniphyllum Calycinum Extract is extracted from Daphniphyllum calycinum, which has antioxidant activities. |
| S3289 | Daphnoretin | Daphnoretin (Dephnoretin, Thymelol), a biologically active compound isolated from Wikstroemia indica C.A. Mey., is a protein kinase C (PKC) activator. Daphnoretin inhibits the proliferation, invasion, and migration of tumor cells and promote its apoptosis by regulating the activity of Akt signal pathway. |
| S9980 | DAPI Dihydrochloride | DAPI Dihydrochloride (DAPI 2HCl) is a fluorescent dye that binds strongly to adenine–thymine-rich regions in DNA. |
| S5281 | Dapiprazole Hydrochloride | Dapiprazole Hydrochloride (Glamidolo Hydrochloride, Reversil Hydrochloride) is the hydrochloride salt form of dapiprazole, an alpha-adrenergic blocker used to reverse mydriasis after eye examination. |
| S2914 | Dapivirine (TMC120) | Dapivirine (TMC120) is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates. Phase 3. |
| S2799 | Daporinad (FK866) | Daporinad (FK866) effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase; Nampt) with IC50 of 0.09 nM in a cell-free assay. Daporinad (FK866, APO866) triggers autophagy. Phase 1/2. |
| S1869 | Dapoxetine HCl | Dapoxetine HCl (LY-210448) is a short-acting novel selective serotonin reuptake inhibitor, used for the treatment of premature ejaculation. |
| S8171 | Daprodustat (GSK1278863) | Daprodustat (GSK1278863) is an orally administered hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) inhibitor. Phase 2. |
| S4612 | Dapson | Dapson (Dapsone, 4,4′-Diaminodiphenyl sulfone, 4,4′-Sulfonyldianiline, 4-Aminophenyl sulfone, Bis(4-aminophenyl) sulfone, DDS), also known as diaminodiphenyl sulfone (DDS), is an antibiotic commonly used in combination with rifampicin and clofazimine for the treatment of leprosy. |
| S2215 | DAPT | DAPT is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells. DAPT enhances the apoptosis of human tongue carcinoma cells and regulates autophagy. |
| S1373 | Daptomycin | Daptomycin is a novel antibiotic with rapid in vitro bactericidal activity against gram-positive organisms. |
| S7520 | Darapladib | Darapladib is a reversible lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with IC50 of 0.25 nM. Phase 3. |
| A2027 | Daratumumab (anti-CD38) | Daratumumab (anti-CD38) is a recombinant monoclonal antibody to CD38. Daratumumab is an investigational anti-cancer drug which is indicated for the treatment of adult patients with multiple myeloma. MW =145.4 kDa. |
| S3144 | Darifenacin HBr | Darifenacin HBr (UK-88525) is a selective M3 muscarinic receptor antagonist with pKi of 8.9. |
| S7559 | Darolutamide (ODM-201) | Darolutamide (ODM-201, BAY-1841788) is a novel androgen receptor (AR) antagonist that blocks AR nuclear translocation with Ki of 11 nM. Phase 3. |
| S6723 | Darovasertib (LXS-196) | Darovasertib (LXS-196, IDE-196) is a selective inhibitor of protein kinase C (PKC). |
| A5426 | DARPP32 Rabbit Recombinant mAb | DARPP32 Rabbit Recombinant mAb detects endogenous level of total DARPP32. |
| S5250 | Darunavir | Darunavir (TMC114,DRV) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection. |
| S1620 | Darunavir Ethanolate | Darunavir Ethanolate (TMC-114, UIC 94017) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection. |
| S9494 | Darutigenol | Darutigenol has antithrombotic effect and may be related to inhibition of platelet aggregation and adhesion. |
| S5402 | Dasabuvir (ABT-333) | Dasabuvir (ABT-333) is a non-nucleoside inhibitor of NS5B viral RNA-dependent RNA polymerase that inhibits recombinant NS5B polymerases derived from HCV genotype 1a and 1b clinical isolates with IC50 values between 2.2 and 10.7 nM. It is at least 7,000-fold selective for the inhibition of HCV genotype 1 polymerases over human/mammalian polymerases. |
| S1021 | Dasatinib | Dasatinib is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM in cell-free assays, respectively. Dasatinib induces autophagy and apoptosis with anti-tumor activity. |
| S5254 | Dasatinib hydrochloride | Dasatinib hydrochloride (BMS-354825) is the hydrochloride salt form of dasatinib, an inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM in cell-free assays, respectively. |
| S7782 | Dasatinib Monohydrate | Dasatinib Monohydrate (BMS-354825) is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM, respectively. |
| D4050 | Datopotamab deruxtecan | Datopotamab deruxtecan (DS-1062, DS-1062A, Anti-TRP2/dxd) is an antibody-drug conjugate (ADC) composed of a humanized anti-TROP2 monoclonal antibody, conjugated to topoisomerase I inhibitor, via a tetrapeptide-based linker. Datopotamab deruxtecan has the potential for use in solid tumors mainly in advanced unresectable advanced NSCLC. |
| S3035 | Daunorubicin HCl | Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM in a cell-free assay. Daunorubicin is a topoisomerase II inhibitor that induces apoptosis. |
| S9295 | Dauricine | Dauricine, a plant metabolite isolated from the Asian vine Menispermum dauricum, plays a variety of biological roles in the human body, from inhibiting cancer cell growth to blocking cardiac transmembrane Na+, K+, and Ca2+ ion currents.Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF‐κB signaling pathway in colon cancer cells. |
| A5116 | Daxx Rabbit Recombinant mAb | Daxx Rabbit Recombinant mAb detects endogenous levels of total Daxx. |
| E3308 | Daylily Flower Extract | Daylily Flower Extract, isolated from the flower and bud parts of Hemerocallis citrina, has the effects of neuroprotection. |
| A5323 | DAZL Rabbit Recombinant mAb | DAZL Rabbit Recombinant mAb detects endogenous level of total DAZL. |
| S0541 | Dazoxiben hydrochloride | Dazoxiben hydrochloride (HCl) is a potent, selevtive and orally active inhibitor of thromboxane (TX) synthase. Dazoxiben inhibits TXB2 production in clotting human whole blood with IC50 of 0.3 μM and causes parallel enhancement of PGE2 production. |
| S6740 | DB07268 | DB07268 is a potent and selective JNK1 inhibitor with an IC50 value of 9 nM and exhibits at least 70- to 90-fold greater potency against JNK1 than CHK1, CK2, and PLK. |
| S7199 | DBeQ | DBeQ (JRF 12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor with IC50 of 1.5 μM. |
| S8296 | dBET1 | dBET1 is a CRBN-based BET degrader with an IC50 of 20 nM, showing highly selectivity. Out of 7,429 proteins, only the expression of the oncoproteins MYC and PIM1, as well as BRD2, BRD3 and BRD4 are significantly downregulated by dBET1 treatment. |
| S0137 | dBET57 | dBET57 is a novel, potent and selective degrader of BRD4BD1 based on the PROTAC technology with DC50/5h of 500 nM. dBET57 is inactive on BRD4BD2. |
| S8762 | dBET6 | dBET6 is a highly cell-permeable PROTAC degrader of BET bromodomains with an IC50 of 14 nM for BRD4 binding. dBET6 also induces c-MYC downregulation and apoptosis. |
| E1144 | dBRD9 | dBRD9 is a bifunctional molecule that links a small molecule that specifically binds to the bromodomain of BRD9 and another ligand that recruits the cereblon E3 ubiquitin ligase, potently and selectively degrades BRD9 with IC50 of 104 nM in MOLM-13 cells. |
| S2711 | DBZ (Dibenzazepine) | DBZ (Dibenzazepine) is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 nM and 2.9 nM in cell-free assays for APPL and Notch cleavage, respectively. |
| S3543 | DC-05 | DC-05 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC50 and a Kd of 10.3 μM and 1.09 μM, respectively. |
| S0742 | DC260126 | DC260126, a small organic antagonist for GPR40 (FFAR1), dose-dependently inhibits GPR40-mediated Ca2+ elevations stimulated by linoleic acid, oleic acid, palmitoleic acid and lauric acid (IC50=6.28, 5.96, 7.07, 4.58 μM, respectively), reduces GTP-loading and ERK1/2 phosphorylation stimulated by linoleic acid in GPR40-CHO cells, suppresses palmitic acid potentiated glucose-stimulated insulin secretion, and negatively regulates GPR40 mRNA expression induced by oleic acid in Min6 cells. |
| S8808 | DC661 | DC661 is capable of deacidifying the lysosome and inhibiting autophagy significantly better than hydroxychloroquine (HCQ). DC661 induces apoptosis. |
| S8615 | DCA (Sodium dichloroacetate) | DCA (Sodium dichloroacetate), a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress Na+-K+-2Cl- cotransporter and a mitochondrial potassium-ion channel axis. Sodium dichloroacetate increases reactive oxygen species (ROS) generation, triggers apoptosis in cancer cells, and inhibits tumor growth. |
| A5771 | DCAMKL1 Rabbit Recombinant mAb | DCAMKL1 Rabbit Recombinant mAb detects endogenous levels of total DCAMKL1. |
| S9889 | dCBP-1 | dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP by hijacking the E3 ubiquitin ligase CRBN, also is exceptionally potent at killing multiple myeloma cells and can abolish the enhancer that drives MYC oncogene expression. |
| E1810 | dCeMM1 | dCeMM1 is a degrader of RBM39. dCeMM1 functions by altering the activity of the CRL4DCAF15 ligase, and also decreases RBM39 expression levels in wild-type KBM7 cells. |
| S8976 | DCLK1-IN-1 | DCLK1-IN-1 is a selective, in vivo-compatible chemical probe of the doublecortin like kinase 1 (DCLK1) domain that binds to DCLK1 and DCLK2 with IC50 of 9.5 nM and 31 nM, respectively. DCLK1-IN-1 inhibits DCLK1 and DCLK2 kinases with IC50 of 57.2 nM and 103 nM in kinase assay, respectively. |
| E0001 | DCPIB | DCPIB is a specific and potent inhibitor of volume-regulated anion channels (VRAC). DCPIB potently inhibits several K2P channels with no voltage dependence, including TRESK, TASK1, and TASK3. DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μM, demonstrating at least 100-fold higher affinity over TREK1/TRAAK channels. DCPIB is also a novel selective blocker of I(Cl,swell), which blocks native I(Cl,swell) of calf bovine pulmonary artery endothelial (CPAE) cells with an IC(50) of 4.1 μM. |
| A5506 | DDAH1 Rabbit Recombinant mAb | DDAH1 Rabbit Recombinant mAb detects endogenous level of total DDAH1. |
| S0081 | DDD107498 | DDD107498 (M-5717, DDD-498) is a P. falciparum translation elongation factor 2 inhibitor. DDD107498 exhibits a potent and novel spectrum of antimalarial activity against multiple life-cycle stages of the Plasmodium parasite. |
| A5462 | DDIT3 Rabbit Recombinant mAb | DDIT3 Rabbit Recombinant mAb detects endogenous level of total DDIT3. |
| S7498 | DDR1-IN-1 | DDR1-IN-1 is a potent and selective discoidin domain receptor 1 (DDR1) receptor tyrosine kinase inhibitor with IC50 of 105 nM, about 3-fold selectivity over DDR2. |
| A5468 | DDR2 Rabbit Recombinant mAb | DDR2 Rabbit Recombinant mAb detects endogenous level of total DDR2. |
| A5921 | DDX5 Rabbit Recombinant mAb | DDX5 Rabbit Recombinant mAb detects endogenous levels of total DDX5. |
| A5418 | DDX58 Rabbit Recombinant mAb | DDX58 Rabbit Recombinant mAb detects endogenous level of total DDX58. |
| E0671 | Deacetylasperulosidic acid | Deacetylasperulosidic acid, a major phytochemical constituent of Morinda citrifolia fruit, has antioxidant activity by increasing superoxide dismutase (SOD) activity, as well as anticlastogenic activity by suppressing the induction of chromosome aberrations in Chinese hamster ovary cells and mice. |
| S9778 | Debio 0123 | WEE1-IN-5 (Debio 0123) is a potent Wee1 inhibitor that inhibits phospho-CDC2 and abrogates the G2 check point. |
| S4072 | Decamethonium Bromide | Decamethonium Bromide is a nicotinic AChR partial agonist and neuromuscular blocking agent. |
| E4005 | Decamethylcyclopentasiloxane | Decamethylcyclopentasiloxane(Cyclomethicone 5) is an organosilicon compound. It is used in cosmetic and personal products as a skin emollient. |
| S7541 | Decernotinib (VX-509) | Decernotinib (VX-509) is a potent and selective JAK3 inhibitor with Ki of 2.5 nM, >4-fold selectivity over JAK1, JAK2, and TYK2, respectively. Phase 2/3. |
| S1200 | Decitabine | Decitabine is a DNA methyltransferase inhibitor, incorporating into DNA and resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. It is used to treat myelodysplastic syndrome (MDS). Decitabine induces cell cycle arrest and apoptosis in various cancer cell lines. |
| S4145 | Decoquinate | Decoquinate is a coccidiostat. |
| E3363 | Decumbent Bugle Herb Extract | Decumbent Bugle Herb Extract is extracted from Ajuga ciliata Bunge., has antioxidant properties. |
| S9264 | Decursin | Decursin is a pyranocoumarin obtained from the roots of Angelica gigas Nakai that exhibits anti-cancer, anti-inflammatory and neuroprotective activities. |
| S5376 | Decyl aldehyde | Decyl aldehyde (Decanal, Capraldehyde, Decanaldehyde) is a naturally occuring organic compound that is used in fragrances and flavoring. |
| E3434 | Deer antler velvet Extract | Deer Antler Velvet Extract is extracted from deer antler velvet, which helps in stimulating the growth of skin and hair cells. |
| S4521 | DEET | DEET (N,N-Diethyl-meta-toluamide, diethyltoluamide) is a commen active ingredient insect repellent. |
| S7654 | Defactinib (VS-6063) | Defactinib (VS-6063, PF-04554878) is a selective, and orally active FAK inhibitor. Phase 2. |
| S6512 | Defensamide (MHP) | Defensamide (MHP) is an activator of sphingosine kinase (SPHK1). It can modulate the innate epidermal immune response by potentiating SPHK1 activity and inducing cAMP production. |
| S1712 | Deferasirox | Deferasirox is an iron chelator, also a cytochrome P450 3A4 inducer, Cytochrome P450 2C8 inhibitor, and Cytochrome P450 1A2 inhibitor. Deferasirox-induced iron depletion promotes BclxL downregulation and cell death. |
| S4067 | Deferiprone | Deferiprone (CP20) is a chelating agent with an affinity for ferric ion (iron III)，binds with ferric ions to form neutral 3:1 (deferiprone:iron) complexes that are stable over a wide range of pH values. |
| E0117 | Deferitrin | Deferitrin(GT-56-252) is a novel oral iron chelator for the treatment of chronic iron overload due to blood transfusion therapy. |
| S5742 | Deferoxamine mesylate | Deferoxamine mesylate is the mesylate salt of Deferoxamine, which forms iron complexes and is used as a chelating agent. Deferoxamine is a ferroptosis inhibitor that stabilizes HIF-1α expression and improves HIF-1α transactivity in hypoxic and hyperglycemic states in vitro. Deferoxamine decreases beta-amyloid (Aβ) deposition and induces autophagy.Please do not prepare stock solutions with normal saline or PBS, as precipitation may occur. |
| S1888 | Deflazacort | Deflazacort (MDL 458) is a glucocorticoid used as an anti-inflammatory and immunosuppressant. |
| E1412 | DEG-35 | DEG-35 is a cereblon-dependent degrader of IKZF2 and casein kinase 1α (CK1α). It blocks cell growth and delays leukemia progression in murine and human acute myeloid leukemia (AML) mouse models. |
| E1413 | DEG-77 | DEG-77 is a cereblon-dependent degrader of IKZF2 and casein kinase 1α (CK1α). It blocks cell growth and delays leukemia progression in murine and human acute myeloid leukemia (AML) mouse models. |
| P1094 | Degarelix acetate | Degarelix acetate (ASP-3550 acetate) is a potent and long-acting luteinizing hormone-releasing hormone (LHRH) antagonist. |
| S2243 | Degrasyn (WP1130) | Degrasyn (WP1130) is a selective deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor and also suppresses Bcr/Abl, also a JAK2 transducer (without affecting 20S proteasome) and activator of transcription (STAT). Degrasyn (WP1130) induces apoptosis and blocks autophagy. |
| S3226 | Dehydroabietic acid | Dehydroabietic acid (DAA, DHAA), a naturally occurring diterpene resin acid derived from coniferous plants such as Pinus and Picea, displays anti-inflammatory activity via suppression of Src-, Syk-, and TAK1-mediated pathways. |
| S4522 | Dehydroacetic acid | Dehydroacetic acid (Biocide 470F, Methylacetopyronone) is an organic compound, used mostly as a fungicide and bactericide. |
| S3807 | Dehydroandrographolide | Dehydroandrographolide, isolated from Andrographis paniculata (Burm. F.) Nees (Chuan-xin-lian), is a novel TMEM16A inhibitor and possesses multiple pharmacological activities, including anti-inflammation, anti-cancer, anti-bacterial, anti-virus and anti-hepatitis activity. |
| S9224 | Dehydroandrographolide Succinate | Dehydroandrographolide succinate (DAS), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, has antibacterial and antiviral effects. |
| S4562 | Dehydrocholic acid | Dehydrocholic acid (Decholin, Dehystolin, Felacrinos, Sanocholen) is a semisynthetic bile acid made from cholic acid. It is used as a cholagogue, hydrocholeretic, diuretic, and as a diagnostic aid. |
| S3615 | Dehydrocostus Lactone | Dehydrocostus lactone (DHE), a natural sesquiterpene lactone, inhibits IKKβ activity, IκBα phosphorylation and degradation, coactivators p300 recruitments and p50/p65 NF-κB nuclear translocation, and their DNA binding activity on COX-2 promoter. It has anti-inflammatory, anti-ulcer, immunomodulatory and anti-tumor properties. |
| S9098 | Dehydrodiisoeugenol | Dehydrodiisoeugenol, a naturally occurring lignan from Aristolochia taliscana (Aristolochiaceae), acts as a potent anti-inflammatory agent and shows various pharmacological activities, including anti-lipid peroxidation, anti-bacteial function, and hepatic drug metabolism enzyme inhibition. |
| S3816 | Dehydroevodiamine | Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood flow enhancing activities. Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells. |
| S7921 | DEL-22379 | DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ∼0.5 μM. |
| S1553 | Delafloxacin (ABT-492) | Delafloxacin (ABT-492, RX-3341, WQ-3034) is a new fluoroquinolone against 155 aerobic and 171 anaerobic pathogens. |
| S4488 | Delafloxacin Meglumine | Delafloxacin (ABT-492, RX-3341, WQ-3034, Baxdela) meglumine is a broad-spectrum fluoroquinolone antibiotic against multiple pathogens. |
| S5007 | Delamanid | Delamanid (OPC-67683) is a new anti-tuberculosis drug with an excellent intracellular bactericidal activity and a high accumulation rate. |
| S1157 | Delanzomib | Delanzomib is an orally active inhibitor of the chymotrypsin-like activity of proteasome with IC50 of 3.8 nM, with only marginal inhibition of the tryptic and peptidylglutamyl activities of the proteosome. Phase 1/2. |
| S5728 | Delapril Hydrochloride | Delapril Hydrochloride (Alindapril) is the hydrochloride salt form of delapril, which is a lipophilic, non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. |
| S6452 | Delavirdine mesylate | Delavirdine Mesylate(U 90152 mesylate) is a mesylate salt form of delavirdine, which is a synthetic, non-nucleoside reverse transcriptase inhibitor. |
| S8802 | Delgocitinib (JTE-052) | Delgocitinib (JTE-052) is a specific JAK inhibitor with IC50s of 2.8, 2.6, 13 and 58 nM for JAK1, JAK2, JAK3 and Tyk2, respectively. |
| S7224 | Deltarasin | Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ. |
| S9463 | Demecarium Bromide | Demecarium Bromide, an anticholinesterase, is an inhibitor of monoamine oxidase (MAO). It induces long-term miosis and decreases intraocular pressure (IOP) in normotensive eyes of Beagles and of eyes of Beagles with inherited glaucoma. |
| S4279 | Demeclocycline HCl | Demeclocycline HCl(Demeclocycline hydrochloride) is a tetracycline antibiotic via inhibition of protein synthesis by bacteria, used for the treatment of bacterial infections. |
| S9280 | Demethoxycurcumin | Demethoxycurcumin, a natural demethoxy derivative of curcumin, has anti-oxidant, anti-inflammatory, anti-cancer, and anti-angiogenesis properties. |
| S3294 | Demethyl-Coclaurine | Demethyl-Coclaurine (Higenamine, Norcoclaurine), the key component of the Chinese herb aconite root, is a beta-2 adrenergic receptor (β2-AR) agonist. Demethyl-Coclaurine stimulates AKT phosphorylation and requires PI3K activation for the anti-apoptotic effect in cardiomyocytes. |
| S3299 | Demethyleneberberine | Demethyleneberberine (DMB), a component of Cortex Phellodendri Chinensis (CPC), significantly alleviates the weight loss and diminishes myeloperoxidase (MPO) activity, while significantly reduces the production of pro-inflammatory cytokines, such as interleukin (IL)-6 and tumor necrosis factor-α (TNF-α), and inhibits the activation of NF-κB signaling pathway. Demethyleneberberine (DMB) potentially ameliorates NAFLD (Non-alcoholic fatty liver disease) by activating AMPK pathways. |
| S9421 | Demethylnobiletin | Demethylnobiletin (5-Demethylnobiletin) is a unique flavonoid found in citrus fruits with potential chemopreventive effects against human cancers.5-Demethylnobiletin is a direct inhibitor of 5-LOX with IC50 of 0.1 μM, without affecting the expression of COX-2. 5-Demethylnobiletin has anti-inflammatory activity, inhibits leukotriene B 4(LTB4) formation in rat neutrophils and elastase release in human neutrophils with IC50 of 0.35 μM. |
| S3608 | Demethylzeylasteral (T-96) | Demethylzeylasteral (T-96), the active component isolated from Tripterygium wilfordii Hook F., inhibits UDP-glucuronosyltransferase (UGT) isoforms UGT1A6 and UGT2B7 with immunosuppressive effects. |
| E3640 | Dendrobii caulis Extract | Dendrobii Caulis Extract is extracted from Dendrobii Caulis, which can protect fibroblasts against UVA-induced photoaging via JNK/c-Jun/MMPs pathway. |
| S9476 | Dendrobine | Dendrobine, a plant alkaloid isolated from Dendrobium nobile, has been used for the quality control and discrimination of Dendrobium. |
| S6370 | Dendrophenol | Dendrophenol (Moscatilin) is from Dendrobium nobile, a naturally occurring bibenzyl compound with potential antimutagenic activity. Dendrophenol (Moscatilin) almost completely suppresses (97%) the AFB1-induced SOS response with an IC50 of 0.08 μM. |
| S9714 | Denifanstat (TVB-2640) | Denifanstat (TVB-2640) is an orally bioavailable, pharmacological fatty acid synthase (FAS/FASN) inhibitor with therapeutic potential in patients with NAFLD and nonalcoholic steatohepatitis. |
| A2020 | Denosumab (anti-RANK ligand) | Denosumab (anti-RANK ligand) (AMG-162, Prolia, Xgeva) is a fully human monoclonal antibody that selectively inhibits primate RANKL. Denosumab inhibits the ability of human RANKL (143–317) to stimulate the formation of osteoclasts derived from murine RAW 264.7 cells with an IC50 value of 1.64 nM. |
| S3237 | Deoxyaconitine | 3-Deoxyaconitine is a diterpenoid alkaloid isolated from the root of Aconitum Carmichaeli Debx. |
| S4132 | Deoxyarbutin | DeoxyArbutin(D-arbutin,D-Arb) is a reversible tyrosinase inhibitor, inhibiting tyrosinase activity with IC50 of 50 nM. |
| S4689 | Deoxycholic acid | Deoxycholic acid (Deoxycholate, Desoxycholic acid, Cholerebic, Cholorebic) is a cytolytic agent. The physiologic effect of deoxycholic acid is by means of decreased cell membrane integrity. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity. |
| S3069 | Deoxycholic acid sodium salt | Deoxycholic acid sodium salt (Sodium Deoxycholate, Sodium Desoxycholate, Cholanoic Acid, ATX-101, Kythera, Belkyra, DCA) is specifically responsible for activating the TGR5 receptor (GPCR19) that stimulates brown adipose tissue (BAT) thermogenic activity. |
| S4243 | Deoxycorticosterone acetate | Deoxycorticosterone acetate (11-Deoxycorticosterone, DOC, Cortexone) is a steroid hormone used for intramuscular injection for replacement therapy of the adrenocortical steroid. |
| E2017 | Deoxypodophyllotoxin | Deoxypodophyllotoxin (DPT), a derivative of podophyllotoxin, is a lignin from Anthriscus sylvestris with potent antimitotic, anti-inflammatory and antiviral activities. |
| E4505 | Deoxyribonucleic acid, single stranded from salmon testes | Deoxyribonucleic acid, single-stranded from salmon testes, is a ready-to-use solution of a high-quality, sonicated, single-stranded template nonspecific DNA blocking agent that reduces background in nucleic acid hybridization. |
| D4042 | Depatuxizumab mafodotin | Depatuxizumab Mafodotin (Depatux-M, ABT-414) is an antibody-drug conjugate consisting of an EGFR IGg1 monoclonal antibody conjugated to the tubulin inhibitor monomethyl auristatin F via a stable maleimidocaproyl link. Depatuxizumab Mafodotin is used in the treatment of recurrent EGFR-amplified Glioblastoma (GBM). |
| S4066 | Dequalinium Chloride | Dequalinium Chloride is a PKC inhibitor with IC50 of 7-18 μM, and also a selective blocker of apamin-sensitive K+ channels with IC50 of 1.1 μM. |
| S5711 | Deracoxib | Deracoxib (SC-046) is a COX-2 inhibitor with >48-fold selectivity over COX-1. It also exhibits inhibitory activity against phosphodiesterase (Ki = 3.6 μM against human PDE4D3). |
| S8609 | Derazantinib | Derazantinib is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with IC50 values of 1.8 nM for FGFR2, and 4.5 nM for FGFR1 and 3, showing lower potency for FGFR4 (IC50=34 nM). It also inhibits RET, DDR2, PDGFRβ, VEGFR and KIT. |
| S0272 | Derenofylline (SLV320) | Derenofylline (SLV320) is a selective and potent adenosine A1 antagonist with Ki of 1 nM. Derenofylline shows selective for adenosine A1 over A2A, A2B, and A3 receptors with Ki of 398 nM, 3981 nM, and 200 nM, respectively. |
| S9795 | Deruxtecan | Deruxtecan is an ADC drug-linker conjugate composed of the cleavable glycine–glycine–phenylalanine–glycine tetrapeptide-based linker, a self-immolative amino methylene spacer, and a novel topoisomerase 1 inhibitor payload that is a derivative of exatecan (DX-8951). |
| E1265 | Deschloroclozapine | Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs (muscarinic Designer Receptors Exclusively Activated by Designer Drugs) agonist, and binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively. |
| S0443 | Desciclovir | Desciclovir (DCV, 6-Deoxyacyclovir, BW A515U) is a prodrug of the antiherpetic agent acyclovir (ACV) that converted into ACV by xanthine oxidase in humans. |
| E3187 | Descolor Cinquefoil Herb Extract | Descolor Cinquefoil Herb Extract is extracted from Potentilla, which has anti-diabetic efficacy and may have beneficial effects on improving glucose uptake. |
| E3700 | Descurainiae Semen Lepidii Semen Extract | Descurainiae Semen Lepidii Semen Extract is obtained from the dried ripe seeds of Descurainia sophia (L.) Webb ex Prantl or Lepidium apetalum Willd. (Brassicaceae), which has anti-inflammatory, analgesic, antipyretic, anticancer, and antioxidant properties, and is also used to treat functional constipation. |
| S3562 | Deserpidine | Deserpidine (Harmonyl), an alkaloid isolated from the roots of Rauwolfia canescens, is a competitive angiotensin converting enzyme (ACE) inhibitor, also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex. |
| E3585 | Desertliving cistanche herb Extract | Desertliving Cistanche Herb Extract is extracted from Cistanche deserticola, which can regulate bone metabolism. |
| S9699 | Desidustat | Desidustat (ZYAN1, ZYAN1-1001), an antianaemic drug candidate, is an orally active hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor (HIF-PHI) that stimulates erythropoiesis. |
| S5485 | Desipramine Hydrochloride | Desipramine hydrochloride (Desmethylimipramine, Norimipramine, EX-4355, G-35020, JB-8181, NSC-114901) is a dibenzazepine-derivative tricyclic antidepressant that acts as a selective norepinephrine reuptake inhibitor. It also shows weak serotonin reuptake inhibitory, α1-blocking, antihistamine, and anticholinergic effects. |
| E0680 | Deslanoside | Deslanoside(Desacetyllanatoside C) is a cardenolide glycoside, has the effects of anti-arrhythmia and cardiotonic, also is used as an EC 3.6.3.9 (Na+/K+-transporting ATPase) inhibitor. |
| S4012 | Desloratadine | Desloratadine (SCH-34117, NSC 675447) is a potent antagonist for human histamine H1 receptor with IC50 of 51 nM. |
| S0761 | Desmethyl Celecoxib | Desmethyl Celecoxib (compound 3b), an analog of Celecoxib with the optimal yield of 75%, is a selective inhibitor of cyclooxygenase-2 (COX-2) with anti-inflammatory activities. |
| S2205 | DesMethyl Erlotinib (OSI-420) HCl | DesMethyl Erlotinib (OSI-420) HCl is the active metabolite of Erlotinib (EGFR inhibitor with IC50 of 2 nM). |
| S6518 | Desmethylanethol trithione | Desmethylanethol trithione (ADT-OH) is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. |
| A5253 | Desmin Rabbit Recombinant mAb | Desmin Rabbit Recombinant mAb detects endogenous level of total desmin. |
| P1084 | Desmopressin Acetate | Desmopressin is a synthetic octapeptide, and an analogue of human hormone arginine vasopressin with antidiuretic and coagulant activities. It is a selective agonist for the vasopressin V2 receptor (V2R). |
| S4638 | Desogestrel | Desogestrel (Cerazette, Desogen, Desogestrelum, Org-2969) is a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents. |
| S1701 | Desonide | Desonide is a low potency topical corticosteroid. |
| S5685 | Desoximetasone | Desoximetasone (Desoxymethasone, Desoximetasonum) is a synthetic glucocorticoid receptor agonist with metabolic, anti-inflammatory and immunosuppressive activity. |
| S3300 | Desoxyrhaponticin | Desoxyrhaponticin (DC, DES), a stilbene glycoside from Rheum tanguticum Maxim. ex Balf. (rhubarb) which is a traditional Chinese nutritional food, is a fatty acid synthase (FAS/FASN) inhibitor. Desoxyrhaponticin (DC, DES) is also a competitive inhibitor of glucose uptake with IC50 of 148.3 μM and 30.9 μM in rabbit intestinal membrane vesicles and in rat everted gut sleeves, respectively. Desoxyrhaponticin has apoptotic effect on human cancer cells. |
| S4113 | Desvenlafaxine | Desvenlafaxine (WY 45233 Succinate) is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with Ki of 40.2 nM and 558.4 nM, respectively. |
| S4112 | Desvenlafaxine Succinate hydrate | Desvenlafaxine Succinate hydrate (WY 45233) is a new serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor with Ki of 40.2 nM and 558.4 nM respectively. |
| S2092 | Detomidine HCl | Detomidine HCl(MPV 253AII) produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors. |
| S8879 | Deucravacitinib (BMS-986165) | Deucravacitinib (BMS-986165) is a highly potent and selective allosteric inhibitor of Tyk2 with a Ki value of 0.02 nM for binding to the Tyk2 pseudokinase domain. It is highly selective against a panel of 265 kinases and pseudokinases. |
| S3535 | Deudextromethorphan (AVP-786) | Deudextromethorphan (AVP-786) is an active N-methyl-D-aspartate (NMDA) receptor antagonist. |
| E1502 | Deutenzalutamide | Deutenzalutamide (HC-1119, MDV3100) is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells. It can be used in a treatment of advanced prostate cancer. |
| E4041 | Deuterium oxide | Deuterium oxide (D2O, heavy water), also known as heavy water, is a stable and non-radioactive isotopic form of water widely used in high-resolution NMR studies. It also serves as a safe and inexpensive source of deuterium (D) for D/H exchange reactions. |
| E3226 | Devil's Claw Extract | Devil'S Claw Extract is extracted from Harpagophytum, which is used in a wide range of health conditions, including indigestion, fever, allergic reactions, and rheumatism. |
| S2776 | Devimistat (CPI-613) | Devimistat (CPI-613), a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase in NCI-H460 cell line, disrupts tumor cell mitochondrial metabolism. CPI-613 induces apoptosis in pancreatic cancer cells. Phase 2. |
| S1322 | Dexamethasone | Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. Dexamethasone induces autophagy and mitophagy. Dexamethasone is tested in hospitalized patients with COVID-19 and is found to have benefits for critically ill patients. |
| S3124 | Dexamethasone Acetate | Dexamethasone (NSC 39471,Dexamethasone 21-acetate) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. |
| S5184 | Dexamethasone palmitate | Dexamethasone palmitate (DXP), a lipophilic prodrug of Dexamethasone (DXM), is a glucocorticoid receptor agonist with a 47-fold lower affinity for the glucocorticoid receptor than DXM. Dexamethasone palmitate (DXP) exhibits anti-inflammatory activity. |
| S5956 | Dexamethasone phosphate disodium | Dexamethasone phosphate disodium is a glucocorticoid receptor agonist with both anti-inflammatory and anti-oxidative effects. |
| S4028 | Dexamethasone Sodium Phosphate | Dexamethasone (Dexamethasone 21-phosphate disodium salt) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. |
| S4099 | Dexlansoprazole | Dexlansoprazole (T 168390, TAK 390,(R)-Lansoprazole), the dextrorotatory enantiomer of lansoprazole, is a proton pump inhibitor (PPI) formulated to have dual delayed-release properties. Dexlansoprazole selectively suppresses gastric acid secretion by direct inhibition of the H(+),K(+)-ATPase proton pump in the gastric parietal cell. |
| S2090 | Dexmedetomidine HCl | Dexmedetomidine HCl((+)-Medetomidine Hydrochloride) is a highly selective and potent alpha-2 adrenoceptor agonist, which reduces anesthetic requirements for patients by providing significant sedation. |
| S5651 | Dexrazoxane | Dexrazoxane (ICRF-187) is an anticancer drug able to block mitosis and to arrest dividing cells. It is an iron chelator and provides cardioprotection against anthracycline toxicity. |
| S1222 | Dexrazoxane HCl | Dexrazoxane HCl is an intracellular iron chelator, which decreases the formation of superoxide radicals, used as a cardioprotective agent; also an inhibitor of topoisomerase II |
| S4492 | Dextran | Dextran (Dextran 40, Macrodex) is a kind of biocompatible, nontoxic and nonimmunogenic biological substance that has been widely used in drug-delivery systems. |
| S6929 | Dextran sulfate sodium (DSS) | Dextran sulfate sodium (DSS) is a potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) in vitro that inhibits virus adsorption to the host cells. |
| S2123 | Dextrose | Dextrose (D-(+)-Glucose), a simple sugar (monosaccharide), is an important carbohydrate in biology. |
| E2877 | dextrothyroxine sodium | Dextrothyroxine (D-T4) sodium, a sodium salt of D-T4, is a laevorotatory isomer of thyroxine used for thyroid related studies. |
| S6849 | DFO | DFO (9H-1,8-Diazafluoren-9-one) is a fluorochrome that is used in the forensic field to enhance latent fingerprints deposited on porous surfaces by reacting with the amino acids present in the papillary exudate. |
| S0531 | DG172 dihydrochloride | DG-172 dihydrochloride is a novel PPARβ/δ-selective antagonist with the IC50 of 27 nM. |
| A5242 | DGCR8 Rabbit Recombinant mAb | DGCR8 Rabbit Recombinant mAb detects endogenous level of total DGCR8. |
| S9643 | DGY-06-116 | DGY-06-116 is an irreversible covalent and selective inhibitor of Src with IC50 of 2.6 nM. |
| S2290 | DHA (Dihydroartemisinin) | DHA (Dihydroartemisinin) is a semi-synthetic derivative of artemisinin and isolated from the traditional Chinese herb Artemisia annua. Dihydroartemisinin induces autophagy and apoptosis by suppressing NF-κB activation. |
| S6454 | DHA (Docosahexaenoic Acid) | DHA (Docosahexaenoic Acid) is essential for the growth and functional development of the brain in infants. DHA is also required for maintenance of normal brain function in adults. |
| S3700 | DHBP dibromide | DHBP (1,1'-diheptyl-4,4'-bipyridinium), a viologen for electrochromic memory display agent, inhibits the calcium release induced by 2 mM caffeine and 2 μg/ml polylysine with an IC50 value of 5 μg/ml and 4 μg/ml respectively. |
| A5568 | DHFR Rabbit Recombinant mAb | DHFR Rabbit Recombinant mAb detects endogenous level of total DHFR. |
| S0747 | DHODH-IN-11 | DHODH-IN-11 is a Leflunomide derivative and a weak inhibitor of dihydroorotate dehydrogenase (DHODH). |
| S1664 | Di(N-succinimidyl) adipate | Di(N-succinimidyl) adipate (DSAP) is an alkyl chain-based PROTAC linker that is applicable to the synthesis of PROTACs. |
| S8796 | diABZI STING agonist (Compound 3) | diABZI STING agonist (diABZI STING agonist-1, Compound 3, Tautomerism) is a potent non-nucleotide STING agonist and has tremendous potential to improve treatment of cancer in humans.Solutions are unstable and should be fresh-prepared. |
| S4267 | Diacerein | Diacerein is an inhibitor of pro-inflammatory cytokine Interleukin-1B (IL-1B) production, prescribed for osteoarthritis and chronic inflammatory arthritis. |
| S3622 | Diammonium Glycyrrhizinate | Diammonium glycyrrhizinate (DG), a traditional Chinese medicine (TCM), is extracted and purified from liquorices (Radix glycyrrhizae). It is known for its anti-inflammatory effects, resistance to biologic oxidation and membranous protection. DG is able to reduce inflammatory injury via suppression of NF‑κB, TNF‑α and intercellular adhesion molecule 1. |
| S6984 | Dianhydrogalactitol (VAL-083) | Dianhydrogalactitol (VAL-083, Dianhydrodulcitol, Dulcitol Diepoxide) is a bi-functional alkylating agent that readily crosses the blood-brain barrier and creates N7 methylation on DNA. Dianhydrogalactitol shows antitumor activity. |
| S6810 | Diarylpropionitrile (DPN) | Diarylpropionitrile (DPN) is a non-steroidal estrogen receptor β (ERβ) agonist with EC50 of 0.85 nM, 72-fold more selective for ERβ than ERα. |
| S4820 | Diastase | Diastase, a natural enzyme, catalyses the breakdown of starch into maltose. |
| S4816 | Diatrizoate sodium | Diatrizoate sodium (Amidotrizoate sodium, Hypaque sodium, Triombrin) is an iodinated radiopaque X-ray contrast medium that is used as a diagnostic aid in angiography, urography and radiography. |
| S4563 | Diatrizoic acid | Diatrizoic Acid (Amidotrizoic acid, Diatrizoate) is an organic, iodinated radiocontrast agent used in diagnostic radiography. |
| S5200 | Diaveridine | Diaveridine (AI3-23935, CCRIS-3784) is coccidiostat with anti-parasitic activity and also a dihydrofolate reductase (DHFR) inhibitor preventing folic acid synthesis in species of Pneumocystis. |
| S5292 | Diazolidinyl urea | Diazolidinyl urea (Germall II) is an antimicrobial preservative used in cosmetics. |
| S4630 | Diazoxide | Diazoxide is a well-known small molecule that activates KATP channels in the smooth muscle of blood vessels and pancreatic beta-cells by increasing membrane permeability to potassium ions. |
| S5432 | Dibenamine Hydrochloride | Dibenamine (N-(2-Chloroethyl)dibenzylamine, Sympatholytin, Dibenzylchlorethamine) is an irreversible blocker of α1 adrenoceptors. |
| S4205 | Dibenzothiophene | Dibenzothiophene (DBT,Diphenylene sulfide) is a model compound for organic sulfur in fossil fuels. |
| S5474 | Dibenzoyl Thiamine | Dibenzoyl Thiamine (Bentiamine, O,S-Dibenzoylthiamine), a lipophilic derivative of vitamin B (thiamine), is a kind of food additive that can be rapidly absorbed into the body and converted to thiamine. |
| S4038 | Dibucaine HCl | Dibucaine HCl (Cinchocaine) is a local anesthetics. |
| S5377 | Dibutyl phthalate | Dibutyl phthalate is widely used as plasticizer in numerous kinds of products such as plastic packaging in food industries. |
| S6041 | Dibutyl sebacate | Dibutyl sebacate is an organic chemical which is mainly used as a plasticizer in the production of plastics. |
| S7858 | Dibutyryl-cAMP (Bucladesine) | Dibutyryl-cAMP (Bucladesine, dbcAMP) is a cell-permeable PKA activator by mimicing the action of endogenous cAMP. Dibutyryl-cAMP (Bucladesine) is also a phosphodiesterase (PDE) inhibitor. |
| S5724 | Dichlorophen | Dichlorophen (Dichlorophene, Bis(5-chloro-2-hydroxyphenyl)methane) is an anticestodal agent, fungicide, germicide, and antimicrobial agent. |
| S2177 | Dichlorphenamide | Dichlorphenamide (Diclofenamide) is a sulfonamide and a carbonic anhydrase inhibitor of the meta-Disulfamoylbenzene class. |
| E3656 | Dichroa febrifuga Extract | Dichroa Febrifuga Extract is extracted from Dichroa Febrifuga, which can Suppress PI3K/AKT and MAPK Signaling Pathways. |
| E3085 | Dichroae Radix Extract | Dichroae Radix Extract is drawed from Dichroae radix, exhibits good clinical efficacy in treatments as an antimalarial, expectorant or antifebrile agent in Chinese medicine, and it also has an anticoccidial effect in chickens infected by coccidiosis when used alone or as the main herb to formulate a complex. |
| S2028 | Diclazuril | Diclazuril(R-64433) is an anti-coccidial drug. |
| S6073 | Diclofenac acid | Diclofenac acid is a nonsteroidal anti-inflammatory drug that has analgesic, anti-inflammatory, and antipyretic properties, and has been shown to be effective in treating a variety of acute and chronic pain and inflammatory conditions. It inhibits cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency. |
| S3063 | Diclofenac Diethylamine | Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. Diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency. |
| S5737 | Diclofenac Epolamine | Diclofenac Epolamine (DHEP, DIEP, diclofenac hydroxyethylpyrrolidine) is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. |
| S3062 | Diclofenac Potassium | Diclofenac potassium (CGP-45840B) is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. |
| S1903 | Diclofenac Sodium | Diclofenac Sodium (GP 45840) is a non-selective COX inhibitor with IC50 of 0.5 μg/ml and 0.5 μg/ml for COX-1 and -2 in intact cells, respectively, used as a nonsteroidal anti-inflammatory drug (NSAID) to relieve pain and reduce swelling in flammation. |
| S4111 | Dicloxacillin Sodium | Dicloxacillin Sodium (Veracillin, BRL1702) is a β-lactamase resistant penicillin similar to oxacillin and it has activity against gram-positive/negative aerobic and anaerobic bacteria. |
| S5969 | Dicloxacillin Sodium hydrate | Dicloxacillin Sodium hydrate (DLX, Dycill, Dynapen, Pathocil), a narrow-spectrum β-Lactam antibiotic of the penicillin class, induces drug-metabolizing CYP enzymes to a clinically relevant extent. |
| S4299 | Dicoumarol | Dicoumarol is a competitive NADPH quinone oxidoreductase (NQO1) inhibitor,and used as an anticoagulant by interfering with the metabolism of vitamin K. |
| S9292 | Dictamnine | Dictamnine, a natural plant product, has been reported to have antimicrobial activity against bacteria and fungi. |
| S4873 | Dicyclanil | Dicyclanil is a pyrimidine-derived regulator of insect growth used for topical treatment of sheep to prevent larval infestation by the blowfly. |
| S1702 | Didanosine | Didanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM. |
| E2939 | Didox | Didox (3,4-dihydroxy-benzohydroxamic acid) is a synthetic ribonucleotide reductase (RR) inhibitor derived from polyhydroxy-substituted benzohydroxamic acid. Didox inhibits proliferation of tamoxifen-resistant breast cancer cells. |
| S9235 | Didymin | Didymin (Neoponcirin, Isosakuranetin-7-O-rutinoside) is a citrus-derived natural compound that kills p53 wild-type as well as drug-resistant p53-mutant neuroblastoma cells in culture. It possesses antioxidant, anti-inflammation and anti-cancer properties. |
| S1858 | Dienestrol | Dienestrol(Restrol) is a synthetic, non-steroidal estrogen. It is an estrogen receptor agonist. |
| S1251 | Dienogest | Dienogest (STS 557) is an orally active synthetic progesterone, used for contraception and the treatment of endometriosis. |
| S6208 | Diethyl malonate | Diethyl malonate, naturally occuring in grapes and strawberries, is used in the synthesis of chemicals. |
| S3312 | Diethyl phosphate | Diethyl phosphate (DEP, DPF, Diethyl phosphoric acid, diethyl hydrogen phosphate), a non-specific metabolite of organophosphorus pesticides in the gut environment, significantly enriches opportunistic pathogens leading to a decrease in interleukin-6 (IL-6). |
| E2921 | Diethyl Pyrocarbonate | Diethyl pyrocarbonate is a potent, non-specific inhibitor of RNase. It has been useful as an in vitro agent, relatively specific for binding to imidazole of histidine. It inhibits central chemosensitivity in rabbit and can modify Ser, Thr, His and Tyr residues. |
| S6209 | Diethyl succinate | Diethyl succinate (Butanedioic acid diethyl ester) is the diethyl ester of succinate and acts as an irritant. |
| S4564 | Diethylcarbamazine citrate | Diethylcarbamazine citrate is an inhibitor of arachidonic acid metabolism in filarial microfilaria and is highly specific for several parasites and does not contain any toxic metallic elements. |
| S4712 | Diethylmaleate | Diethylmaleate (Diethyl ester, Maleic acid diethyl ester) is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-κB. |
| S1859 | Diethylstilbestrol | Diethylstilbestrol (Stilbestrol) is a synthetic nonsteroidal estrogen, used to prevent miscarriage and other pregnancy complications. |
| P1151 | Difelikefalin | Difelikefalin (CR-845, FE-202845), a peripherally restricted and selective agonist of kappa opioid receptor (KOR), produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease. |
| S5360 | Diflorasone | Diflorasone acts as a corticosteroid hormone receptor agonist with anti-inflammatory and immunosuppressive properties. |
| S5041 | Difloxacin hydrochloride | Difloxacin is a second-generation, synthetic fluoroquinolone antimicrobial antibiotic used in veterinary medicine. |
| S5414 | Diflucortolone valerate | Diflucortolone valerate (Afusona, Diflucortolone 21-valerate) is a potent corticosteroid esterified with valeric acid. It helps reduce swelling, itching, and redness. |
| S4609 | Diflunisal | Diflunisal (Dolobid, Dolobis, Flovacil, Fluniget,MK-647) is a difluorophenyl derivate of salicylic acid and a nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic and anti-inflammatory properties. The mechanism of action of diflunisal is as a Cyclooxygenase Inhibitor. |
| S4095 | Difluprednate | Difluprednate (difluoroprednisolone butyrate acetate, DFBA, CM 9155) is a synthetic difluorinated prednisolone derivative, it is originally developed for dermatologic applications. |
| E1321 | Digitonin | Digitonin, a steroidal saponin and glycoside obtained from Digitalis purpurea, has strong lytic activity on various cell membranes with an IC50 of 15.1 µM on sheep RBC membranes. |
| S4290 | Digoxin | Digoxin is a classical Na,K-ATPase inhibitor, with selectivity for the α2β3 isoform over the common α1β1 isoform, used in the treatment of atrial fibrillation and heart failure.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing. |
| S5030 | Dihydralazine sulphate | Dihydralazine sulphate (Nepresol, Depressan, 1,4-Dihydrazinophthalazine, Hydralazine) is a dihydralazine-l,4-phthalazine derivative and used as an antihypertensive drug. |
| E0211 | Dihydroberberine | Dihydroberberine, a hydrogenated derivative of Berberine (BBR), exerts anti-inflammatory effect via dual modulation of NF-κB and MAPK signaling pathways. |
| S9086 | Dihydrocapsaicin | Dihydrocapsaicin (6,7-Dihydrocapsaicin, 8-Methyl-N-vanillylnonanamide, CCRIS1589), found in pepper (C. annuum), is a potential nutriceutical.DHC is a selective TRPV1 agonist. |
| S5123 | Dihydrocholesterol | Dihydrocholesterol (Beta-Cholestanol, Zymostanol, 5alpha-Cholestanol) is a cholesterol derivative found in human feces, gallstones, eggs, and other biological matter. |
| S9379 | Dihydrocoumarin | Dihydrocoumarin, a compound found in Melilotus officinalis (sweet clover) and Dipteryx odorata Willd (tonka beans), is added as a flavoring agent to a wide variety of foods, including soft drinks, yogurt, and muffins, and is used as a common fragrance in cosmetics, lotions, and soaps. |
| S6792 | Dihydroethidium | Dihydroethidium (DHE, HE, Hydroethidine, PD-MY 003) is a cell-permeable blue fluorogenic probe used for detecting intracellular superoxide radical anion. |
| S9446 | Dihydrokavain | Dihydrokavain (Marindinin) is a kavalactone source from kava beverages used in herbal medicine to treat sleep disturbances, as well as stress and anxiety. |
| E2286 | Dihydrolanosterol | Dihydrolanosterol (24,25-Dihydrolanosterol; Dihydrolanosterin; Lanostenol) inhibits cholesterol biosynthesis by promoting ubiquitination and degradation of HMG CoA reductase. |
| S3285 | Dihydrolycorine | Dihydrolycorine is a derivative of lycorine, an alkaloid isolated from Lycoris radiata Herb. Dihydrolycorine blocks protein synthesis in ascites cells and stabilize HeLa cell polysomes in vivo. Dihydrolycorine exhibits antihypertensive and neuroprotective activities. |
| S6927 | Dihydroresveratrol | Dihydroresveratrol is a natural product possessing significant biological activities. Dihydroresveratrol, a potent phytoestrogen, is a hormone receptor modulator. |
| S4523 | Dihydrostreptomycin sulfate | Dihydrostreptomycin sulfate is an aminoglycoside antibiotic, used to treat bacterial diseases in cattle, pigs and sheep. Dihydrostreptomycin is a derivative of streptomycin. |
| S9020 | Dihydrotanshinone I | Dihydrotanshinone I (15,16-dihydrotanshinone I) is a naturally occurring compound extracted from Salvia miltiorrhiza Bunge, also known as Chinese sage, red sage root, and the Chinese herbal Dan Shen. It is a potent inhibitor of the HuR:RNA interaction, active in the low nanomolar range, mainly by limiting the association rate of HuR with RNA. |
| S3702 | Dihydrothymine | Dihydrothymine is an intermediate breakdown product of thymine. |
| E0750 | Dihydrouracil | Dihydrouracil (5,6-Dihydrouracil) is an intermediate in the catabolism of uracil. Dihydrouracil (5,6-Dihydrouracil) can be used as a standard for ureido group in the colorimentric assay of transfer ribonucleic acid (tRNA). |
| S2990 | Dihydroxyfumaric acid hydrate | Dihydroxyfumaric acid hydrate (DHF) is an endogenous metabolite. The diester derivative of dihydroxyfumaric acid hydrate (DHF) has been used exclusively as an electrophile in organic synthesis. |
| S4565 | Diiodohydroxyquinoline | Diiodohydroxyquinoline (Iodoquinol) is a topical therapeutic agent,a quinoline derivative, with satisfactory antibacterial properties. |
| E0114 | Dilmapimod (SB-681323) | Dilmapimod (SB-681323,GW 681323) is a potent p38 MAPK inhibitor that potentially suppresses inflammation in chronic obstructive pulmonary disease. |
| S1865 | Diltiazem HCl | Diltiazem (Tiazac, RG 83606) HCl is a benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions. |
| S5221 | Diludine | Diludine (Ethidine, Diethone) is a synthetic antioxidant agent. |
| S6785 | DIM-C-pPhCO2Me | DIM-C-pPhCO2Me is a nuclear receptor 4A1 (NR4A1)(Nur77) antagonist with antineoplastic activity. |
| S6799 | DIM-C-pPhOH | DIM-C-pPhOH (C-DIM8, CDIM8) is a nuclear receptor 4A1 (NR4A1)(Nur77) antagonist. DIM-C-pPhOH inhibits tumor growth and mTOR signaling, induces apoptosis and cellular stress. DIM-C-pPhOH reduces cell proliferation with IC50 of 13.6 μM and 13.0 μM for ACHN cells and 786-O cells, respectively. |
| S4672 | Dimenhydrinate | Dimenhydrinate is an over-the-counter drug used to prevent nausea, vomiting, and dizziness caused by motion sickness. |
| S4446 | Dimercaprol | Dimercaprol (Bal, 2,3-Dimercapto-1-propanol, Dithioglycerol) is an acrolein scavenger that inhibits HIV-1 tat activity, viral production, and infectivity in vitro. |
| S1201 | Dimesna | Dimesna (BNP-7787) is an uroprotective agent used to decrease urotoxicity. |
| E1796 | Dimethindene maleate | Dimethindene maleate is a selective antagonist of histamine H1 and exhibits antihistamine effects. It suppresses the cromakalim-induced/glibenclamide-sensitive K+ currents in a concentration-dependent and reversible manner. |
| S4985 | Dimethyl 4-Hydroxyisophthalate | Dimethyl 4-Hydroxyisophthalate (4-Hydroxyisophthalic acid dimethyl ester) is used as a building block in the chemical synthesis. |
| E1281 | Dimethyl itaconate | Dimethyl itaconate can reprogram neurotoxic to neuroprotective primary astrocytes through the regulation of LPS-induced Nod-like receptor protein 3 (NLRP3) inflammasome and nuclear factor 2/heme oxygenase-1 (NRF2/HO-1) pathways. |
| S5378 | Dimethyl phthalate | Dimethyl phthalate is an organic compound, used as an insect repellent for mosquitoes and flies. |
| E2999 | Dimethyl pimelimidate dihydrochloride | Dimethyl pimelimidate dihydrochloride (DMP) is a homobifunctional amine-reactive crosslinker which is readily hydrolyzed at neutral pH. |
| S6311 | Dimethyl Trisulfide | Dimethyl trisulfide (Methyl trisulfide, DMTS, 2,3,4-trithiapentane) is an organic chemical compound and the simplest organic trisulfide. |
| S6197 | Dimethylamine hydrochloride | Dimethylamine is a precursor to several industrially significant compounds. |
| S6630 | Dimethylcurcumin (ASC-J9) | Dimethylcurcumin (ASC-J9, Dimethyl curcumin, GO-Y025) is an androgen receptor (AR) degradation enhancer that suppresses castration-resistant prostate cancer growth through degradation of full-length and splice variant androgen receptors. |
| S0279 | Dimethylenastron | Dimethylenastron is a potent, specific and reversible inhibitor of kinesin Eg5 (kinesin-5/kinesin spindle protein, KSP) with IC50 of 200 nM. Dimethylenastron induces mitotic arrest and apoptosis and upregulate Hsp70 in human multiple myeloma cells. |
| S5541 | Dimetridazole | Dimetridazole is an anti-fungal and anti-protozoal used for the control of infection in pigs, poultry, turkeys, game birds, pigeons and other caged birds. |
| S4104 | Diminazene Aceturate | Diminazene(Diminazene diaceturate) is a di-amidine also known as 4,4-(1-Triazene–1,3–diyl)bis(benzenecarboximidamide), used as an effective trypanocidal agent. The main biochemical mechanism of the trypanocidal actions of Diminazene aceturate is by binding to trypanosomal kinetoplast DNA (kDNA) in a non-intercalative manner through specific interaction with sites rich in adenine-thymine base pairs. Diminazene aceturate is also an angiotensin-converting enzyme 2 (ACE2) activator and has strong and potent anti-inflammatory properties. |
| E2870 | dimyristoyl lecithin | dimyristoyl lecithin (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine is used for the study of lipid monolayers and bilayers. |
| S2768 | Dinaciclib | Dinaciclib is a novel and potent CDK inhibitor for CDK2, CDK5, CDK1 and CDK9 with IC50 of 1 nM, 1 nM, 3 nM and 4 nM in cell-free assays, respectively. It also blocks thymidine (dThd) DNA incorporation. Dinaciclib induces apoptosis through the activation of caspases 8 and 9. Phase 3. |
| E3150 | Dinian Herb Extract | Dinian Herb Extract is extracted from Melastoma dodecandrum, which can regulate postprandial blood glucose. |
| S4141 | Dinitolmide | Dinitolmide (Zoalene) is a broad-spectrum anticoccidial drug. |
| S5056 | Dinoprost tromethamine | Dinoprost Tromethamine (Dinolytic, PGF2-alpha tham, Zinoprost, Prostin F2 alpha, Dinoprost Trometamol) is a synthetic analogue of the naturally occurring prostaglandin F2 alpha, which stimulates myometrial activity, relaxes the cervix, inhibits corpus luteal steroidogenesis, and induces luteolysis by direct action on the corpus luteum. |
| E0176 | Dinotefuran | Dinotefuran (MTI-446), a neonicotinoid, is an effective nAChRs agonist with EC50 of 7.8 μM and shows high insecticidal activity on Da2b2 hybrid nAChRs. |
| S2379 | Dioscin | Dioscin (Collettiside III, Saponin) is a saponin extracted and isolated from Polygonatum Zanlanscianense Pamp, showing antitumor activities. |
| E3060 | Dioscorea Sativa Extract | Dioscorea Sativa Extract is obtained from the dried roots of Dioscorea septemloba Thunbt and Dioscorea hypoglauca Palibin (Dioscoreaceae). |
| E3106 | Dioscoreae Nipponicae Rhizoma Extract | Dioscoreae Nipponicae Rhizoma Extract is extracted from the rhizome of Dioscorea nipponica, of which the main component decreases the phosphorylation in IGF-1R, which in turn inhibits the phosphorylation and activation of PI3K-AKT and Rap1-MEK signaling pathways, promoting cell apoptosis and Graves’ disease remission. |
| S2380 | Diosmetin | Diosmetin (Luteolin 4-methyl ether) is a bioflavonoid found in spearmint, oregano, and many other plants. |
| S2292 | Diosmin | Diosmin is an agonist of the aryl hydrocarbon receptor (AhR). Diosmin is a semisynthetic phlebotropic agent and a flavonoid found in a variety of citrus fruits. |
| E3650 | Diospyroskaki leaf Extract | Diospyroskaki Leaf Extract is extracted from the leaf of Diospyros kaki Thunb.. |
| S4034 | Diphemanil Methylsulfate | Diphemanil Methylsulfate is a quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors (mAchR). |
| S1866 | Diphenhydramine HCl | Diphenhydramine HCl is a first-generation histamine H1 receptor antagonist, used in various allergic conditions such as rhinitis, urticaria and conjunctivitis. |
| S4292 | Diphenidol HCl | Diphenidol HCl(Diphenidol hydrochloride) is a potent antagonist of muscarinic M2 and M3 receptor with pKb of 6.72 and 7.02, respectively, used in the treatment of vomiting and vertigo. |
| S5604 | Diphenylamine Hydrochloride | Diphenylamine (N-Phenylbenzenamine, Anilinobenzene, C.I. 10355), a derivative of aniline, is widely used as an industrial antioxidant, dye mordant and reagent and is also employed in agriculture as a fungicide and antihelmintic. Diphenylamine can inhibits oxidative phosphorylationsignificantly, although its inhibition potency was weaker than that of NSAIDs with a diphenylamine structure. |
| S5656 | Diphenylpyraline hydrochloride | Diphenylpyraline hydrochloride is the hydrochloride salt form of diphenylpyraline, which is an antihistamine used in the treatment of allergic rhinitis, hay fever, and allergic skin disorders. |
| S0866 | Diphenylterazine (DTZ) | Diphenylterazine (DTZ), a synthetic coelenterazine analog, is a bioluminescence agent. Diphenylterazine alone yields very little background, leading to excellent signal-to-background ratios. Diphenylterazine treatment can track tumor growth in a xenograft NU/J mouse model. |
| E0019 | Dipivefrin Hydrochloride | Dipivefrin (Dipivefrine, Propine, Pivalephrine) is a prodrug of epinephrine which is hydrolyzed to epinephrine after absorption into the eye. |
| S9222 | Dipotassium glycyrrhizinate | Glycyrrhizinate dipotassium (Neubormitin) is a widely used anti-inflammatory agent isolated from the licorice root. |
| P1134 | diprotin A | Diprotin A (Ile-Pro-Ile) is an inhibitor of dipeptidyl peptidase IV (DPP-IV). |
| S1895 | Dipyridamole | Dipyridamole is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. |
| S6592 | Diquafosol Tetrasodium | Diquafosol Tetrasodium (INS-365), a P2Y2 receptor agonist, is a pharmaceutical drug for the treatment of dry eye disease. |
| E2905 | DIRECT RED 80 | Direct Red 80 (Sirius Red) is a polyazo dye used principally in staining methods for collagen and amyloid. Direct Red 80 does not release benzidine upon degradation and is safer than many traditional direct dyes. |
| S4213 | Dirithromycin | Dirithromycin (LY-237216, ASE 136,Dynabac) is a macrolide glycopeptide antibiotic by binding to the 50S subunit of the 70S bacterial ribosome to inhibit the translocation of peptides. |
| S6421 | Diroximel Fumarate | Diroximel Fumarate (ALKS-8700) is a prodrug of monomethyl fumarate in a controlled-release formulation that rapidly and efficiently converts to MMF in the body. |
| D4049 | Disitamab vedotin | Disitamab Vedotin (RC-48 ,RC 480-ADC) is an antibody-drug conjugate(ADC) composed of anti-[ERBB2 (epidermal growth factor receptor 2, receptor tyrosine-protein kinase erbB-2, EGFR2, HER2, HER-2, p185c-erbB2, NEU, CD340)] humanized monoclonal antibody, conjugated to monomethylauristatin E (MMAE), via a cleavable maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl (mc-val-cit-PABC) type linker. Disitamab Vedotin has the potential for use in solid tumors mainly in advanced breast cancer. |
| P1218 | Disitertide(P144) | Disitertide (P144) is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor, is also a PI3K inhibitor and an apoptosis inducer. |
| S7873 | Disodium (R)-2-Hydroxyglutarate | Disodium (R)-2-Hydroxyglutarate (D-α-Hydroxyglutaric acid disodium) is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 10.87 ± 1.85 mM. |
| S3327 | Disodium 5'-inosinate monohydrate | Disodium 5'-inosinate monohydrate (Inosine 5'-monophosphate disodium salt hydrate) is an endogenous metabolite. |
| S1911 | Disodium Cromoglycate | Disodium Cromoglycate (Gynazole ,FPL 670 (Cromolyn) Disodium,Cromolyn sodium) is an antiallergic drug with IC50 of 39 μg/mL. |
| S5011 | Disodium Phosphate | Disodium Phosphate (Sodium hydrogen phosphate, Sodium phosphate dibasic) is an inorganic compound used usually as food additives. It is also functions as a corrosion inhibitor. |
| S5490 | Disopyramide | Disopyramide is a class IA antiarrhythmic drug which acts via blockade of sodium channels depressing phase 0 of the action potential. Disopyramide possesses significant negative inotropic, anticholinergic effects and enhances AV nodal conduction. |
| S6002 | Disufenton sodium | Disufenton Sodium (NXY-059, Cerovive) is a novel nitrone, shows efficacious neuroprotective effects. Phase 3. |
| S1680 | Disulfiram | Disulfiram is a specific inhibitor of aldehyde-dehydrogenase (ALDH) with IC50 of 0.15 μM and 1.45 μM for hALDH1 and hALDH2, respectively. Disulfiram is used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram induces apoptosis. Disulfiram is also an inhibitor of pore formation by gasdermin D (GSDMD). |
| S4590 | Dithranol | Dithranol (Anthralin, cignoline, 1,8,9-trihydroxyanthracene) is one of the most important local therapeutic agents against the common skin disease, psoriasis. |
| E3035 | Dittany Bark Extract | Dittany Bark Extract is extracted from the bark of Dittany, which is often used in treating inflammation, bacterial and fungal infections, reducing inflammation and digestive health. |
| S1703 | Divalproex Sodium | Divalproex Sodium, consisting of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form, is a HDAC inhibitor, used in the treatment for epilepsy. |
| E1187 | Divarasib (GDC-6036) | Divarasib (GDC-6036, RG6330) is a KRAS G12C inhibitor that binds irreversibly to switch II pocket of KRAS G12C (when in the inactive GDP-bound state) thereby blocking GTP binding and activation. |
| E3421 | Diverse wormwood herb Extract | Diverse wormwood herb Extract is extracted from Herba Artemisiae Anomalae. |
| S0889 | Dixanthogen | Dixanthogen is an ectoparasiticide. |
| S0083 | DJ-V-159 | DJ-V-159 is an agonist for G protein-coupled receptor family C group 6 member A (GPRC6A). |
| E1480 | DJ4 | DJ4 (EX-A7863) is a potent, selective ATP-competitive inhibitor of ROCK1/2 and MRCKα/β with IC50 of 5/50 nM and 10/100 nM respectively. It blocks stress fiber formation and inhibits migration and invasion of multiple cancer cell line |
| S4954 | Djenkolic Acid | Djenkolic Acid (Jengkolic acid, Djenkolate, S,S'-Methylenebiscysteine) is a naturally occurring sulfur-containing amino acid extracted from djenkol beans. It is toxic to humans, often causing kidney failure. |
| A5345 | DKK1 Rabbit Recombinant mAb | DKK1 Rabbit Recombinant mAb detects endogenous level of total DKK1. |
| S3354 | DL-2,3-Diaminopropionic acid monohydrochloride | DL-2,3-Diaminopropionic acid monohydrochloride (2,3-Diaminopropanoic acid hydrochloride) is an active endogenous metabolite. |
| S5442 | DL-2-Aminoadipic acid | DL-2-Aminoadipic acid is an excitatory amino acid analogue, which functions as a glutamine synthetase inhibitor. |
| S2988 | DL-5-Hydroxylysine hydrochloride | DL-5-Hydroxylysine hydrochloride, an endogenous metabolite, is a racemic mixture of D- and L- enantiomers of 5-hydroxylysine which may be used as potential target markers for radical-induced protein oxidation. |
| S6178 | DL-6,8-Thioctamide | DL-6,8-Thioctamide (alpha-Lipoic amide) is used for protecting liver and health care products. |
| S2523 | DL-Adrenaline | DL-Adrenaline(dl-Epinephrine) is a hormone and a neurotransmitter secreted by the medulla of the adrenal glands. |
| E2979 | DL-AP5 (2-APV) | DL-AP5 (2-APV, DL-2-Amino-5-phosphonovaleric acid) is a competitive antagonist of NMDA (N-methyl-D-aspartate) receptor. It shows significantly antinociceptive activity and specifically blocks on channels in the rabbit retina. |
| S5549 | DL-Arginine | Arginine is an α-amino acid that is used in the biosynthesis of proteins and plays an important role in cell division, wound healing, removing ammonia from the body, immune function, and the release of hormones. |
| S6123 | DL-Benzylsuccinic acid | DL-Benzylsuccinic acid (2-benzylbutanedioic acid, Benzylsuccinic acid) is a bacterial xenobiotic metabolite. |
| E4004 | DL-beta-Hydroxybutyric acid sodium salt | DL-beta-Hydroxybutyric acid sodium salt(β-Hydroxybutyric acid sodium) is a metabolite that is elevated in type I diabetes. It can modulate the properties of membrane lipids. |
| S2433 | DL-Buthionine-Sulfoximine | DL-Buthionine-Sulfoximine (BSO, DL-Buthionine-(S,R)-sulfoximine) is an inhibitor of glutathione (GSH) synthesis. |
| S5937 | DL-Carnitine | DL-Carnitine ((±)-Carnitin) is a racemic mixture of L-Carnitine and D-Carnitine that regulates fatty acid transport in the mitochondrion. DL-carnitine is found to be ineffective or toxic, for example, to muscle cells and to the myocardium. DL-Carnitine causes symptoms of myasthenia and cardiac arrhythmias. |
| S2293 | DL-Carnitine HCl | DL-Carnitine HCl is a quaternary ammonium compound biosynthesized from the amino acids lysine and methionine. |
| S5124 | DL-Citrulline | L-Citrulline (Citrulline, Cit) is a naturally occurring nonessential amino acid which is the key intermediate in the urea cycle. |
| S6083 | DL-Dopa | DL-Dopa (3,4-Dihydroxy-DL-phenylalanine) is an immediate precursor of dopamine. |
| S3963 | DL-Glutamine | DL-Glutamine (Glutamin, 2-amino-4-carbamoylbutanoic acid) is a non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. |
| S2994 | DL-Homocysteine | DL-Homocysteine is a weak neurotoxin that affects the production of kynurenic acid (KYNA) in the brain. DL-Homocysteine inhibits the activity of both KYNA biosynthetic enzymes, kynurenine aminotransferases (KATs) I and II. |
| S6061 | DL-m-Tyrosine | DL-m-Tyrosine is a potent, structurally unusual broad-spectrum phytotoxin exuded by the roots of some fine leaf fescue grasses. |
| S5868 | DL-Menthol | DL-Menthol is a racemic mixture of D- and L-menthol. Menthol is a covalent organic compound made synthetically or obtained from peppermint or other mint oils. |
| S9344 | DL-Methionine | DL-Methionine is an amino acid that has a role in the defence of oxidative stress. |
| S5750 | DL-Norepinephrine hydrochloride | Norepinephrine (noradrenaline) is the neurotransmitter at most sympathetic neuroeffector junctions and has pharmacologic effects on both α1 and β1 adrenoceptors. |
| S6334 | DL-Norvaline | DL-Norvaline (2-Aminopentanoic acid, H-DL-Nva-OH, 2-Aminovaleric acid, α-Aminopentanoic acid) is an important pharmaceutical intermediate. |
| S4566 | DL-Panthenol | DL-panthenol (DL-Pantothenol, DL-Pantothenyl alcohol) is a racemic mixture of D and L form of panthenol,a provitamin of B5. |
| S5962 | DL-Penicillamine | DL-Penicillamine (DL-beta-Mercaptovaline, 3,3-Dimethyl-DL-cysteine, 3-Sulfanylvaline, Cuprimine, Depen, DL-PenA, DL-P) induces alteration of elastic fibers of periosteum-perichondrium and associates growth inhibition. |
| S5545 | DL-Serine | Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2. |
| S2997 | DL-Tartaric acid | DL-Tartaric Acid (2,3-Dihydroxysuccinic acid) is a white, crystalline organic acid isolated from many plants, particularly tamarinds and grapes and is used as an antioxidant and an additive agent to give a sour taste. |
| E4454 | DL-Thiorphan | Thiorphan (DL-3-Mercapto-2-benzylpropanoylglycine) is a selective NEP (neprilysin) inhibitor with an IC50 of 6.9 nM. It is also a potent inhibitor of enkephalinase, with antinociceptive activity. |
| E0191 | DL-α-tocopherol acetate | DL-α-Tocopherol acetate (DL-Alpha-tocopherol acetate , Vitamin E acetate), a vitamin E derivative, is used as a vitamin E supplement in poultry feeds. |
| S0275 | DLin-KC2-DMA | DLin-KC2-DMA is a useful lipid for lipid-based nanoparticle (LNP) delivery system. |
| S3561 | DLinDMA | DLinDMA (1,2-dilinoleyloxy-N,N-dimethyl-3-aminopropane) is a key component to facilitate endosomal escape through membrane fusion between the SNALP and the endosomal membranes. |
| S6773 | DM1 (Mertansine) | DM1 (Mertansine), an antibody-conjugatable maytansinoid, is a selective microtubule inhibitor that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC).Solutions are unstable and should be fresh-prepared. |
| S2982 | DM1-SMCC | DM1-SMCC (SMCC-DM1) is an antibody drug conjugate (ADC)-linker consists of a potent microtubule-disrupting agent DM1 and a linker SMCC. |
| E2659 | DMAT | DMAT is a high affinity and selective casein kinase-2 (CK2) inhibitor with IC50 of ~0.14 μM and Ki of ~40 nM. |
| S2586 | DMF (Dimethyl Fumarate) | DMF (Dimethyl Fumarate) is the methyl ester of fumaric acid, used to treat people with relapsing forms of multiple sclerosis. Dimethyl fumarate is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator and induces upregulation of antioxidant gene expression. |
| S6192 | DMF(N,N-Dimethylformamide) | DMF(N,N-Dimethylformamide) is a polar organic solvent with a wide range of industrial applications.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing. |
| S7146 | DMH1 | DMH1 is a selective BMP receptor inhibitor with IC50 of 107.9 nM for ALK2, exhibiting no inhibition on AMPK, ALK5, KDR (VEGFR-2) or PDGFR. DMH1 inhibits autophagy. |
| S5510 | DMNB | DMNB (4,5-dimethoxy-2-nitrobenzaldehyde) is a volatile organic compound used as a detection taggant for explosives. |
| S6563 | DMNQ | DMNQ is a 1,4-naphthoquinone that acts as a redox-cycling agent, typically increasing intracellular superoxide and hydrogen peroxide formation. |
| S7483 | DMOG | DMOG (Dimethyloxalylglycine) is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolylhydroxylase, leading to stabilisation and accumulation of HIF-1α protein in the nucleus. DMOG enhances autophagy. |
| E2203 | DMU-212 | DMU-212 is a methylated derivative of Resveratrol, with antimitotic, anti-proliferative, antioxidant and apoptosis promoting activities, which can induce mitotic arrest via induction of apoptosis and activation of extracellular-signal-regulated kinase1/2 (ERK1/2) protein. |
| S0175 | DMU2105 | DMU2105 is a potent and specific inhibitor of CYP1B1 with IC50 of 10 nM. |
| S0176 | DMU2139 | DMU2139 is a potent and specific inhibitor of CYP1B1 with IC50 of 9 nM. |
| S0268 | DMX-5084 | DMX-5804 is a potent, orally active and selective inhibitor of Mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4) with IC50 of 3 nM for human MAP4K4. DMX-5804 is more potent on human MAP4K4 with pIC50 of 8.55 than MINK1/MAP4K6 and TNIK/MAP4K7 with pIC50 of 8.18 and 7.96, respectively. |
| L4600 | DNA Damage/DNA Repair compound Library | A unique collection of 850 small molecules used for DNA Damage and Repair research with targeting PARP,ATM/ATR,Topoisomerase,DNA/RNA Synthesis etc. |
| A5820 | DNA Ligase IV Rabbit Recombinant mAb | DNA Ligase IV Rabbit Recombinant mAb detects endogenous levels of total DNA Ligase IV |
| A5473 | DNA Polymerase beta Rabbit Recombinant mAb | DNA Polymerase beta Rabbit Recombinant mAb detects endogenous level of total DNA Polymerase beta. |
| A5876 | DNA-PKcs Rabbit Recombinant mAb | DNA-PKcs Rabbit Recombinant mAb detects endogenous levels of total DNA-PKcs. |
| A5700 | Dnmt1 Rabbit Recombinant mAb | Dnmt1 Rabbit Recombinant mAb detects endogenous level of total Dnmt1. |
| A5984 | Dnmt3a Rabbit Recombinant mAb | Dnmt3a Rabbit Recombinant mAb detects endogenous levels of total Dnmt3a. |
| E1093 | DNPH1i(N6-benzyladenosine) | DNPH1i (N6-benzyladenosine,BAPR) is a competitive inhibitor of adenosine deaminase(ADA) from L-1210 cells in axenic culture as well as a potent antiproliferative agent in vitro and in vivo. |
| E1259 | DNQX | DNQX is an AMPA receptor antagonist that prevents excess calcium influx via voltage-gated calcium channels. |
| S1423 | Dobutamine HCl | Dobutamine(Dobutrex) hydrochloride is a selective potent agonist of β1-AR (β-1 adrenergic receptor) and exhibits weak activity at α1-AR and β2-AR. Dobutamine is a sympathomimetic compound that effectively restores blood pressure in hypotensive dogs and human patients by improving myocardial contractility and increasing cardiac output (CO). |
| S1148 | Docetaxel | Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules. |
| S7787 | Docetaxel Trihydrate | Docetaxel (RP56976, NSC 628503), an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules. |
| S1637 | Docosanol | Docosanol is a saturated fatty alcoholused traditionally as an emollient, emulsifier, and thickener in cosmetics, nutritional supplement. (ED50=2.5 mg/mL for plaque inhibition, and ED50=1.7 mg/mL for inhibition of virus production) |
| S4588 | Docusate Sodium | Docusate Sodium (Aerosol OT, Bis(2-ethylhexyl) sulfosuccinate sodium salt, Constonate) is a laxative used to treat constipation, for constipation due to the use of opiates it maybe used with a stimulant laxative, can be taken by mouth or rectally. |
| S6267 | Dodecanedioic acid | Dodecanedioic acid is a dicarboxylic acid mainly used in antiseptics, top-grade coatings, painting materials, corrosion inhibitors, surfactants, and engineering plastics. |
| S1658 | Dofetilide | Dofetilide (UK-68798) is a selective potassium channel ((hERG)) blocker, used as a Class III antiarrhythmic drug. |
| S5326 | Dolasetron | Dolasetron(MDL-73147EF) is a highly specific and selective serotonin 5-HT3 receptor antagonist. It has minimal activity at other known serotonin receptors, and has low affinity for dopamine receptors. |
| S5679 | Dolasetron Mesylate | Dolasetron Mesylate (Anzemet hydrate,MDL-73147EF) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy. |
| S2667 | Dolutegravir | Dolutegravir is a two-metal-binding HIV integrase inhibitor with IC50 of 2.7 nM in a cell-free assay, modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H. |
| S4642 | Dolutegravir Sodium | Dolutegravir Sodium (GSK-1349572A) is a HIV integrase inhibitor with IC50 of 2.7 nM. |
| S7555 | Domatinostat (4SC-202) | Domatinostat (4SC-202) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. Also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Phase 1. |
| S4186 | Domiphen Bromide | Domiphen bromide (NSC-39415) is a quaternary ammonium antiseptic with actions as a cationic surfactant. |
| S2461 | Domperidone | Domperidone is an oral dopamine D2 receptor antagonist, used to treat nausea and vomiting. |
| S9621 | Donafenib (Sorafenib D3) | Donafenib (Sorafenib D3, Bay 43-9006 D3, CM-4307) is the deuterium labeled Sorafenib. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 15 nM, 20 nM and 22 nM for Raf-1, mVEGFR-2, mVEGFR-3 and B-RAF, respectively. |
| S5073 | Donepezil | Donepezil (Aricept, Donepezilo) is a piperidine based, potent, specific, non-competitive and reversible inhibitor of acetylcholinesterase (AChE) used for the treatment of mild to moderate dementia of the Alzheimer's type. |
| S2462 | Donepezil HCl | Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively. |
| E3001 | Donkey-hide gelatin Extract | Donkey-Hide Gelatin Extract is extracted from Donkey-hide gelatin (Asini Corii Colla, ACC), a gelatinous Chinese medicine known as Ejiao in Chinese. Donkey-hide gelatin is applied as an important food therapy product to optimize immune response, improve metabolic balance and treat gynecological diseases. |
| S2953 | Dooku1 | Dooku1 is an analog of Yoda1 with antagonist activity against mechanosensitive Piezo1 channel. Dooku1 inhibits 2 μM Yoda1-induced Ca2+-entry with IC50 of 1.3 μM in HEK 293 cells and 1.5 μM in HUVECs, respectively. |
| S2529 | Dopamine HCl | Dopamine HCl(ASL279, NSC 173182) is a catecholamine neurotransmitter present in a wide variety of animals,And a dopamine D1-5 receptors agonist. |
| A5831 | Dopamine Receptor D3 Rabbit Recombinant mAb | Dopamine Receptor D3 Rabbit Recombinant mAb detects endogenous levels of total Dopamine Receptor D3 |
| A5144 | Dopamine Transporter Rabbit Recombinant mAb | Dopamine Transporter Rabbit Recombinant mAb detects endogenous level of Dopamine Transporter. |
| S1574 | Doramapimod (BIRB 796) | Doramapimod (BIRB 796) is a pan-p38 MAPK inhibitor with IC50 of 38 nM, 65 nM, 200 nM and 520 nM for p38α/β/γ/δ in cell-free assays, and binds p38α with Kd of 0.1 nM in THP-1 cells, 330-fold greater selectivity versus JNK2, weak inhibition for c-RAF, Fyn and Lck, insignificant inhibition of ERK-1, SYK, IKK2. |
| S5117 | Doramectin | Doramectin (Cyclohexylavermectin B1, Dectomax) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. It is used for the treatment and control of internal parasitosis, ticks and mange. |
| S6492 | Doravirine | Doravirine is a novel HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50 values of 12, 9.7, and 9.7 nM against the wild type (WT) and K103N and Y181C reverse transcriptase (RT) mutants, respectively, in a biochemical assay. It is highly specific with minimum off-target activities. |
| S5531 | Doripenem | Doripenem(S 4661) is a new parenteral carbapenem antibiotic with broad-spectrum activity against gram-negative and gram-positive pathogens. |
| S1374 | Doripenem Hydrate | Doripenem Hydrate (S-4661) is an ultra-broad-spectrum injectable antibiotic, used to treat complicated intra-abdominal infections and complicated urinary tract infections. |
| S7840 | Dorsomorphin | Dorsomorphin is a potent, reversible, selective AMPK inhibitor with Ki of 109 nM in cell-free assays, exhibiting no significant inhibition of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JAK3. Dorsomorphin selectively inhibits the BMP type I receptors ALK2, ALK3 and ALK6. Dorsomorphin is used in promoting specific cell differentiation and inducing cancer cell line autophagy. For animal testing, the water-soluble S7306 Dorsomorphin (Compound C) 2HCl is recommended. |
| S7306 | Dorsomorphin 2HCl | Dorsomorphin 2HCl is a potent, reversible, selective AMPK inhibitor with Ki of 109 nM in cell-free assays, exhibiting no significant inhibition of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JAK3. Also inhibits type Ⅰ BMP receptor activity. Dorsomorphin induces autophagy in cancer cell line. |
| S6921 | Dorzagliatin | Dorzagliatin (HMS-5552, RO-5305552, Sinogliatin) is a dual-acting glucokinase (GK) activator that improves glycaemic control and pancreatic β-cell function in patients with type 2 diabetes. |
| S1375 | Dorzolamide HCl | Dorzolamide (MK-507, L-671152) HCl is a water-soluble, potent inhibitor of human carbonic anhydrase II and IV with Ki of 1.9 nM and 31 nM, respectively, used as anti-glaucoma agent. |
| S6908 | DOTAP chloride | DOTAP chloride (1,2-Dioleoyl-3-trimethylammonium-propane chloride) is an effective cationic lipid widely used as a liposomal transfection reagent. DOTAP is also a strong activator of the innate immune system in animal cells and a good candidate as an elicitor for the study of plant immunity. |
| E2355 | Dotinurad | Dotinurad (FYU-981), a selective urate reabsorption inhibitor (SURI), potently inhibits urate transporter 1 (URAT1) with IC50 of 37.2 nM. |
| E3658 | Double coptis chinensis Extract | Double Coptis Chinensis Extract is extracted from Double Coptis Chinensis, which has antipyretic and anti-inflammatory mechanism. |
| S1018 | Dovitinib (TKI-258) | Dovitinib (TKI258, CHIR258) is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGF-1R and HER2 in cell-free assays. Phase 4. |
| S7765 | Dovitinib (TKI258) Lactate monohydrate | Dovitinib (TKI258) Lactate monohydrate is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGFR1 and HER2. Phase 4. |
| E3221 | Downy Rosemyrtle Root Extract | Downy Rosemyrtle Root Extract is extracted from Rhodomyrtus tomentosa (Ait.) Hassk.. |
| S5257 | Doxapram | Doxapram is a central respiratory stimulant with a brief duration of action. Doxapram is a selective TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel inhibitor with EC50 of 410 nM, 37 μM, 9 μM, respectively. |
| S4037 | Doxapram HCl | Doxapram HCl inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively. |
| S5782 | Doxazosin | Doxazosin(UK 33274) is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors. |
| S1324 | Doxazosin Mesylate | Doxazosin, a quinazoline-derivative, selectively antagonizes postsynaptic α1-adrenergic receptors, used in the treatment of high blood pressure and urinary retention associated with benign prostatic hyperplasia. |
| S3120 | Doxepin HCl | Doxepin is a tricyclic antidepressant formulated as a mixture of E-(trans) and Z-(cis) stereoisomers. It inhibits CYP2D6 activity in vivo. |
| S1467 | Doxercalciferol | Doxercalciferol (1α-hydroxyvitamin D2) is a synthetic vitamin D2 analog, suppressing parathyroid synthesis and secretion, used to treat secondary hyperparathyroidism and metabolic bone disease. |
| S2045 | Doxifluridine | Doxifluridine (5'-DFUR, AMC 0101) is an oral prodrug that is converted to the cytotoxic agent 5-fluorouracil (5-FU). |
| S4164 | Doxofylline | Doxofylline (Doxophylline) is a phosphodiesterase inhibitor and a xanthine derivative drug for asthma. |
| E2516 | Doxorubicin | Adriamycin (Doxorubicin, Hydroxydaunorubicin), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent, inhibits topoisomerase II with an IC50 of 2.67 μM, thus stopping DNA replication, and induces apoptosis, also inhibits human DNA topoisomerase I with an IC50 of 0.8 μM. |
| S1208 | Doxorubicin (DOX) HCl | Doxorubicin (DOX) HCl is an antibiotic agent that inhibits human DNA topoisomerase I and topoisomerase II with IC50s of 0.8 μM and 2.67 μM, respectively. Doxorubicin reduces basal phosphorylation of AMPK. Doxorubicin is used in the concomitant treatment of HIV-infected patients but is found to be at high risk of HBV reactivation.This product may precipitate when dissolved in PBS solution. It is recommended to prepare the stock solution in pure water and dilute with either pure water or saline to obtain the working solution. |
| S5159 | Doxycycline | Doxycycline (Vibramycin, Doxytetracycline, Doxiciclina, Doxycyclinum) is an antibiotic that is used in the treatment of a number of types of infections caused by bacteria and protozoa. Doxycycline is also a nonspecific matrix metalloproteinase (MMP) inhibitor. |
| S4163 | Doxycycline Hyclate | Doxycycline Hyclate is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is also an inhibitor of matrix metallo-proteinases (MMP). |
| S6068 | Doxycycline monohydrate | Doxycycline is a synthetic, broad-spectrum tetracycline antibiotic exhibiting antimicrobial activity. |
| S4240 | Doxylamine Succinate | Doxylamine succinate competitively inhibits histamine at H1 receptors with substantial sedative and anticholinergic effects. |
| S7909 | Dp44mT | Dp44mT is a potent iron chelator, which shows selective antitumor activity. |
| E1310 | DPCPX | DPCPX (PD 116948), a xanthine derivative, is a highly potent and selective adenosine A1 receptor (ADORA1) antagonist, with a Ki of 0.46 nM. |
| E1312 | DPH | DPH is a potent cell permeable c-Abl activator, with an EC50 of 794 nM. |
| S8639 | DPI (Diphenyleneiodonium chloride) | DPI (Diphenyleneiodonium chloride) is an inhibitor of NADPH oxidase and also a potent, irreversible, and time-, temperature-dependent iNOS/eNOS inhibitor. Diphenyleneiodonium chloride (DPI) also functions as a TRPA1 activator and selectively inhibits intracellular reactive oxygen species (ROS). |
| E0376 | DPPE fumarate | DPPE fumarate (Tesmilifene fumarate) is a novel potentiator of chemotherapy, which is found to potentiate a wide range of cytotoxics and to protect normal cells. |
| S6977 | DR2313 | DR2313 is a potent, selective, competitive and brain-penetrant inhibitor of poly(ADP-ribose) polymerase (PARP), with IC50s of 0.20 μM and 0.24 μM for PARP-1 and PARP-2, respectively. |
| S9270 | Dracohodin perochlorate | Dracohodin perochlorate, extracted from Dragon's blood, is widely used in traditional Chinese medicine, especially in wound healing. |
| E3425 | Dragon's blood Extract | Dragon'S Blood Extract is extracted from the resin of Dracaena draco, which has anti-angiogenic activity and anti-hepatoma activity. |
| S9636 | DRB18 | DRB18 is a pan-GLUT (glucose transporters) inhibitor that inhibits growth and proliferation in several different cancer types with IC50 high nM range. |
| S0457 | DREADD agonist 21 | DREADD agonist 21 is a potent agonist of human muscarinic acetylcholine M3 receptors (hM3Dq) with EC50 of 1.7 nM. |
| A5309 | Drebrin Rabbit Recombinant mAb | Drebrin Rabbit Recombinant mAb detects endogenous level of total Drebrin. |
| S5665 | Drofenine Hydrochloride | Drofenine hydrochloride is a potent competitive inhibitor of BChE. It is an anticholinergic that acts both at the level of the nerves and the muscle fibers. |
| S5787 | Dronedarone | Dronedarone (SR33589) is a derivative of amiodarone which is classified as a Class III antiarrhythmic agent. It shows rate-dependent inhibition of the rapid Na+ current, inhibits α and β-adrenergic receptors like Class II agents, exhibits blockade of K+ outward currents as the main mechanism of action of Class III, and effectively block slow Ca2+ inward currents (Class IV). |
| S2114 | Dronedarone HCl | Dronedarone HCl (SR33589) is a multichannel blocker targeting potassium channel, sodium channel and calcium channel, used as an antiarrhythmic drug for treatment of atrial fibrillation (AF). |
| S4096 | Droperidol | Droperidol (NSC 169874,Dehydrobenzperidol) is a potent antagonist of dopamine subtype 2 receptors in the limbic system. |
| S4138 | Dropropizine | Dropropizine (UCB-1967,(±)- Dropropizine) is a racemic non-opiate antitussive agent, it is used as a cough suppressant. |
| S1377 | Drospirenone | Drospirenone (ZK 3059) is a synthetic progestin that is an analog to spironolactone. |
| S3041 | Droxidopa | Droxidopa (L-DOPS) is a psychoactive drug and acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline). |
| S1422 | Droxinostat | Droxinostat (NS 41080) is a selective inhibitor of HDAC, mostly for HDACs 6 and 8 with IC50 of 2.47 μM and 1.46 μM, greater than 8-fold selective against HDAC3 and no inhibition to HDAC1, 2, 4, 5, 7, 9, and 10. |
| L7800 | Drug-like Compound Library | A unique collection of 2260 drug-like compounds used for high throughput screening(HTS) and high content screening(HCS). |
| S8881 | DS-1001b (DS 1001) | DS-1001b is an oral selective inhibitor of mutant IDH1 R132X with potential antineoplastic activity and is designed to penetrate the blood-brain barrier. |
| S0626 | DSP Crosslinker | DSP Crosslinker is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). |
| S0896 | DSP-4 HCl | DSP-4 hydrochloride (Neurotoxin DSP 4 (hydrochloride)) can be used for the temporary selective degradation of the central and peripheral noradrenergic neurons, which exclusively affects the noradrenergic fibers from the LC (locus coeruleus). |
| S0657 | DSS Crosslinker | DSS Crosslinker (Disuccinimidyl suberate) is a membrane permeable homobifunctional crosslinking agent and a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). |
| S8774 | DT-061 (SMAP) | DT-061 (SMAP) is a bioavailable PP2A activator. It decreases cell viability in HCC827 and HCC3255 cell lines, with IC50 values of 14.3 μM and 12.4 μM respectively. |
| S8924 | DT2216 | DT2216 is a potent and selective degrader of BCL-XL based on PROTAC technology. DT2216 inhibits various BCL-XL-dependent leukemia and cancer cells but considerably less toxic to platelets. |
| S9806 | DTHIB | DTHIB (Direct Targeted HSF1 InhiBitor) is a direct and selective inhibitor of heat shock factor 1 (HSF1) with Kd of 160 nM for DTHIB binding to the HSF1 DNA binding domain (DBD). DTHIB exhibits potently anticancer activities. |
| S2764 | DTNB | DTNB (Ellman’s Reag, Ellmans Reagenz, 5,5′-Dithiobis(2-nitrobenzoic acid), 5,5′-Dithiobis-2-nitrobenzoesäure) is a non-fluorescent probe used to quantify the number or concentration of thiol groups in a sample. DTNB is also an allosteric inhibitor of dengue virus protease (NS2B-NS3pro) and Streptomyces proteases. |
| S7637 | DTP3 | DTP3 is a selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor and is able to restore MKK7/JNK activation. DTP3 inhibits cancer-selective NF-κB survival pathway. |
| S6829 | DTT (Dithiothreitol) | DTT (Dithiothreitol), a small-molecule redox reagent, is a standard agent for reducing disulfide bonds between and within biological molecules.Solutions are best fresh-prepared. |
| S7846 | Dubermatinib(TP-0903) | TP-0903 is a potent and selective AXL Inhibitor with IC50 of 27 nM. TP-0903 is highly effective in inducing apoptosis. |
| E0392 | Dubs-IN-1 | Dubs-IN-1 is an active inhibitor of ubiquitin-specific proteases (USPs), with an IC50 of 0.85 μM for USP8. |
| E0389 | DUBs-IN-2 | DUBs-IN-2 is a potent inhibitor of USP7 and USP8 deubiquitinating enzymes. |
| P1115 | Dulaglutide | Dulaglutide is a GLP-1 receptor agonist approved for the management of hyper glycaemia in people with type 2 diabetes in many countries. P1115 is its biologically active polypeptide part, the sequence is His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser- Tyr-Leu-Glu-Glu-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Gly-Gly. |
| S3864 | Dulcitol | Dulcitol (Galactitol, D-Galactitol, Dulcose) is a naturally occurring product of plants obtained following reduction of galactose. |
| S5071 | Duloxetine | Duloxetine (LY-248686) is a potent inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline (NE) uptake in vitro and in vivo and is 3- to 5-times more effective at inhibiting 5-HT uptake. |
| S2084 | Duloxetine HCl | Duloxetine HCl (LY-248686) is a serotonin-norepinephrine reuptake inhibitor with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD). |
| A2038 | Dupilumab (anti-IL-4Rα) | Dupilumab (anti-IL-4Rα) is a fully human anti–interleukin-4 receptor α monoclonal antibody that inhibits both interleukin-4 (IL-4) and interleukin-13 (IL-13) signaling through blockade of the shared IL-4α subunit. |
| A2013 | Durvalumab (anti-PD-L1) | Durvalumab (anti-PD-L1) is a selective, high affinity human IgG1 mAb that blocks programmed cell death ligand-1 (PD-L1) binding to PD-1 (IC50=0.1 nM) and CD80 (IC50=0.04 nM). MW=146.3 kDa. |
| A5382 | DUSP1 Rabbit Recombinant mAb | DUSP1 Rabbit Recombinant mAb detects endogenous level of total DUSP1. |
| S1202 | Dutasteride | Dutasteride (GI198745, GG-745) is a dual 5-α reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone (DHT). |
| S7028 | Duvelisib (IPI-145) | Duvelisib (IPI-145, INK1197) is a novel and selective PI3K δ/γ inhibitor with Ki and IC50 of 23 pM/243 pM and 1 nM/50 nM in cell-free assays, highly selective for PI3K δ/γ than other protein kinases. Phase 3. |
| E1139 | DX3-213B | DX3-213B is a highly potent, orally active oxidative phosphorylation (OXPHOS) complex I inhibitor with IC50 of 3.6 nM, and impairs ATP generation with IC50 of 11 nM. |
| S9666 | DX600 | DX600 is a specific inhibitor of angiotensin-converting enzyme 2 (ACE2) that does not cross-react with ACE. |
| E2891 | Dxd | Dxd(Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM. |
| S2041 | Dyclonine HCl | Dyclonine HCl(Dyclocaine HCl) is a hydrochloride salt form of dyclonine which is an oral anaesthetic, reversibly binds to activated sodium channels on the neuronal membrane, thereby decreasing the neuronal membrane's permeability to sodium ions, leading to an increased threshold for excitation. |
| S4097 | Dydrogesterone | Dydrogesterone (NSC 92336) is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus. |
| A5913 | Dynamin 1 Rabbit Recombinant mAb | Dynamin 1 Rabbit Recombinant mAb detects endogenous levels of total Dynamin 1. |
| A5573 | Dynamin 2 Rabbit Recombinant mAb | Dynamin 2 Rabbit Recombinant mAb detects endogenous level of total Dynamin 2. |
| S8047 | Dynasore | Dynasore is a cell-permeable, reversible non-competitive dynamin inhibitor of GTPase activity of dynamin 1/2, with IC50 of 15 μM in a cell-free assay, also inhibits the mitochondrial dynamin Drp1, with no effect against other small GTPase. Dynasore suppresses mTORC1 activity and induces autophagy. Dynasore inhibits the entry of several viruses, including herpes simplex virus (HSV). |
| S7163 | Dyngo-4a | Dyngo-4a is a potent dynamin inhibitor with IC50 of 0.38 μM, 1.1 μM, and 2.3 μM for DynI (brain), DynI (rec), and DynII (rec), respectively. |
| A5640 | DYNLL1 Rabbit Recombinant mAb | DYNLL1 Rabbit Recombinant mAb detects endogenous level of total DYNLL1. |
| P1131 | Dynorphin (1-17) | Dynorphin (1-17) (Dynorphin A (swine)), an endogenous opioid peptide, is a highy potent kappa opioid receptor (KOR) activator. Dynorphin A also serve as an agonist for other opioid receptors, such as mu (MOR) and delta (DOR)[1]. |
| S1504 | Dyphylline | Dyphylline (Diprophylline) is a xanthine derivative with bronchodilator and vasodilator effects. |
| A5435 | Dysferlin Rabbit Recombinant mAb | Dysferlin Rabbit Recombinant mAb detects endogenous level of total Dysferlin. |
| S7120 | DZNeP (3-deazaneplanocin A) HCl | DZNeP (3-deazaneplanocin A) HCl, an analog of adenosine, is a competitive inhibitor of S-adenosylhomocysteine hydrolase with Ki of 50 pM in a cell-free assay. |
| S6028 | α-D-Glucose anhydrous | Alpha-D-Glucose is a primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is an intermediate in glycolysis/gluconeogenesis pathway. |
| S3302 | β,β-dimethyl-acryl-alkannin | β,β-dimethyl-acryl-alkannin (AN-I, β,β-Dimethylacrylalkannin) is a napthoquinone isolated from roots of Arnebia nobilis Reichb.f. that has the potential to be used as an anti-aging ingredient. |
| S6241 | β-D-Glucose pentaacetate | β-D-Glucose pentaacetate is an enantiomer of D-glucose pentaacetate. |
| S5375 | γ-Decalactone | γ-Decalactone (4-Decanolide, 5-Hexyldihydro-2(3H)-furanone) is a naturally occuring flavor compound, being important in industry with a peachy aroma. |
