A
| 目录号 |
产品名 |
产品描述 |
| F3192 |
ACADS / SCAD Rabbit mAb |
|
| E7971 |
(+)-Afzelechin |
(+)-Afzelechin, isolated from rhizomes of Bergenia ligulata, is an alpha-glucosidase activity inhibitor with an ID50 (50% inhibition dose) value of 0.13 mM. (+)-Afzelechin can delay the absorption of carbohydrates in food to suppress postprandial hyperglycemia and hyperinsulinemia. |
| S3897 |
(-)-Arctigenin |
(-)-Arctigenin, a lignan found in certain plants of the Asteraceae, exerts biological activities including anti-inflammatory, antiviral and anticancer. |
| S1671 |
(6-)ε-Aminocaproic acid |
(6-)ε-Aminocaproic acid is a derivative and analogue of the amino acid lysine. |
| P1212 |
(Ala13)-Apelin-13 |
(Ala13)-Apelin-13 is a potent APJ receptor antagonist and can prevent the apelin-induced reduction in gastric tone and motility.
|
| E7566 |
(±)-Alliin |
(±)-Alliin is the main active component of garlic. (±)-Alliin is a putative inhibitor of the main protease of SARS-CoV-2 (Mpro). |
| E2833 |
1,5-Anhydro-D-glucitol |
1,5-Anhydro-D-glucitol (1,5-Anhydroglucitol, 1,5-AG) is a naturally occurring monosaccharide found in nearly all foods, supporting reliable evidences for early forecast and screening of diabetes mellitus. |
| S6886 |
1-Aminobenzotriazole |
1-Aminobenzotriazole (ABT, 3-Aminobenzotriazole, 1-Benzotriazolylamine, NSC 114498, NSC 656987) is a nonselective and irreversible inhibitor of cytochrome P450 (CYP) enzymes. 1-Aminobenzotriazole is also a substrate and inhibitor of N-acetyltransferase (NAT). |
| S4891 |
1-Aminohydantoin Hydrochloride |
1-Aminohydantoin Hydrochloride is a pharmaceutical and pesticide intermediate. |
| S7193 |
1-Azakenpaullone |
1-Azakenpaullone (1-Akp) is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25. |
| A5680 |
14-3-3 alpha/beta Rabbit Recombinant mAb |
14-3-3 alpha/beta Rabbit Recombinant mAb detects endogenous level of total 14-3-3 alpha/beta. |
| E2400 |
1A-116 |
1A-116 is a Rac1 inhibitor, with antitumoral and antimetastatic effects in several types of cancer, such as breast cancer, prevents Rac1-regulated processes involved in the primary tumorigenesis and metastastic processes. |
| E7933 |
1alpha-Hydroxy VD4 |
1alpha-Hydroxy VD4 , a 1alpha(OH)D derivative, can effectively induce the differentiation of monoblastic leukaemia U937, P39/TSU and P31/FUJ cells. IC50 value；Target: VD analog |
| E0197 |
2-Acetamidofluorene |
2-Acetamidofluorene (2-AAF, 2-Acetaminofluorene, N-2-Fluorenylacetamide, N-Acetyl-2-aminofluorene) is a carcinogenic and mutagenic compound.
|
| S5304 |
2-Acetylphenothiazine (ML171) |
2-Acetylphenothiazine (ML171, 2-APT) is a potent and selective inhibitor of NADPH-oxidase with IC50s of 0.25 μM, 5 μM, 3μM, 5 μM and 5.5 μM for NOX1, NOX2, NOX3, NOX4 and xanthine oxidase, respectively. |
| S6261 |
2-Acetylpyrazine |
2-Acetylpyrazine is one of the volatile flavor constituents in popcorn, wheat and rye bread crust. |
| S3135 |
2-Amino-1-phenylethanol |
2-Amino-1-phenylethanol (2-APE) is a noradrenaline analogue. |
| E7422 |
2-Amino-3-(2-chlorophenyl)propanoic acid |
2-Amino-3-(2-chlorophenyl)propanoic acid is a phenylalanine derivative. |
| S4998 |
2-Aminobenzenesulfonamide |
2-Aminobenzenesulfonamide (Orthanilamide, O-Aminobenzenesulfonamide, O-Sulfanilamide, Benzenesulfonamide) is an inhibitor of Carbonic Anhydrase IX (CAIX) / Carbonic Anhydrase 9 (CA9). |
| S6032 |
2-Aminobenzenesulfonic acid |
2-Aminobenzenesulfonic acid (Orthanilic acid, O-Aminobenzenesulfonic acid, Aniline-2-sulfonic acid) is a biological acid with roles in benzoate degradation and microbial metabolism in diverse environments. |
| S6402 |
2-Aminoethanethiol |
2-Aminoethanethiol (cysteamine, β-Mercaptoethylamine, 2-Mercaptoethylamine, Thioethanolamine, Mercaptamine) is a radiation-protective agent that oxidizes in air to form cystamine. |
| S3331 |
2-Aminoethylphosphonic acid |
2-Aminoethylphosphonic acid (2-AEP, (2-Aminoethyl)phosphonic acid) is a type of abundant and ubiquitous naturally occurring phosphonate used as sources of phosphorus by many prokaryotic lineages. |
| S4520 |
2-Aminoheptane |
2-Aminoheptane (Tuaminoheptanez, Tuamine, Heptamine, 1-Methylhexylamine, 2-Heptylamine) is a nasal decongestant drug which is a sympathomimetic stimulant and vasoconstrictor. |
| S6270 |
2-Aminoisobutyric acid |
2-Aminoisobutyric acid (NSC-16590, 2-Methylalanine, H-Aib-OH) is a rare, non-protein amino acid and end-product of pyrimidine metabolism, excreted in urine and found in some antibiotics of fungal origin. |
| S6657 |
2-APB (2-Aminoethyl Diphenylborinate) |
2-APB (2-Aminoethyl Diphenylborinate) is an IP3 receptor inhibitor and regulate IP3-induced calcium release.2-APB also inhibits the SOC channel activity and inhibits TRP channel at higher concentrations. |
| E5907 |
2-APQC |
2-APQC is a potent activator of SIRT3 with a Kd value of 2.756 μM. It alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis, exhibiting promising cardioprotective potential in vitro and in vivo. It may serve as a potential candidate for future heart failure (HF) therapeutics. |
| E5071 |
3-Acetyl-beta-boswellic acid |
3-Acetyl-beta-boswellic acid is a boswellic acid isolated from Boswellia serrata gum resin. |
| S5977 |
3-Amino-1,2,4-triazole (3-AT) |
3-Amino-1,2,4-triazole (3-AT) is a common irreversible inhibitor of catalase, induces a compensatory mechanism for the hydrogen peroxide detoxification, which includs a rise in glutathione peroxidase (GPX) and glutathione reductase activities. |
| S6361 |
3-Amino-4-hydroxybenzoic acid |
3-Amino-4-hydroxybenzoic acid is a monohydroxybenzoic acid. |
| S6142 |
3-Amino-4-methylpentanoic acid |
3-Amino-4-methylpentanoic acid (beta-Leucine, DL-Homovaline, DL-beta-leucine, beta-Aminoisocaproic acid) is a human metabolite. |
| E2703 |
3-Amino-9-ethylcarbazole |
3-Amino-9-ethylcarbazole (AEC) is a chemical compound commonly used as a chromogenic substrate in immunohistochemistry, specifically for visualizing sections stained with HRP-conjugated secondary antibodies. |
| S1132 |
3-Aminobenzamide |
3-Aminobenzamide (3-ABA , 3-Amino Benzamide, 3-AB) is a potent inhibitor of Poly(ADP-ribose)polymerase (PARP) and inhibits cell apoptosis after SCI (Spinal Cord Injury) in caspase-independent way. |
| S6134 |
3-Aminoisobutyric acid |
3-Aminoisobutyric acid (3-Amino-2-methylpropanoic acid, 3-Aminoisobutyrate, β-aminoisobutyric acid) is a product formed by the catabolism of thymine. |
| S5340 |
3-Aminopropionitrile fumarate |
3-Aminopropionitrile fumarate (Beta-Aminopropionitrile fumarate) is an organic compound and antirheumatic agent used in veterinary medicine. |
| E2920 |
3-Aminopropyltriethoxysilane |
3-Aminopropyltriethoxysilane (γ-Aminopropyltriethoxysilane) is an aminosilane commonly used for biomolecule immobilization on silicon and silicon derivatives such as silicon nitride (Si3N4). |
| E7565 |
360A iodide |
360A iodide is a selective stabilizer of G-quadruplex, and also inhibits telomerase activity with an IC50 of 300 nM for telomerase in TRAP-G4 assay. |
| S3358 |
4-Acetamidobutyric acid |
4-Acetamidobutanoic acid (N-acetyl GABA) is a derivative of Gamma-aminobutyric acid (GABA) resulting from the monoacetylation of the nitrogen of GABA. |
| S5339 |
4-Allylanisole |
4-Allylanisole (Estragole, p-Allylanisole, Methyl chavicol) is a natural organic compound that is a component of various trees and plants. It is used in the preparation of fragrances. |
| E5056 |
4-Allylcatechol |
4-Allylcatechol (4-Allylpyrocatechol) is a xylan isolated from the root of Piper taiwanense. 4-Allylcatechol has a strong inhibitory activity against collagen-induced platelet aggregation (IC50=5.3 μM). In addition, 4-Allylcatechol has anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv (MIC=27.6 μg/mL). |
| E2980 |
4-AMino-1-phenylpyrazolo[3,4-d]pyriMidine |
4-AMino-1-phenylpyrazole[3,4-d]pyriMidine(PP 3) is an EGFR tyrosine kinase inhibitor with an IC50 of 2.7 μM. It is a negative control for the Src kinase inhibitor, PP 2. |
| S3651 |
4-Amino-5-imidazolecarboxamide |
4-Amino-5-imidazolecarboxamide is an imidazole derivative which is a metabolite of the antineoplastic agents BIC and DIC. By itself, or as the ribonucleotide, it is used as a condensation agent in the preparation of nucleosides and nucleotides. |
| S4509 |
4-Aminoantipyrine |
4-Aminoantipyrine(Ampyrone) is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. It is used as a reagent for biochemical reactions producing peroxides or phenols. |
| E7350 |
4-Aminobenzamidine dihydrochloride |
4-Aminobenzamidine (p-Aminobenzamidine) dihydrochloride is a strong trypsin inhibitor, also acting as a relatively weak urokinase type plasminogen activator (uPA) inhibitor (Ki=82 μM). 4-Aminobenzamidine can inhibit growth of a human prostate tumor in SCID mice. |
| S9874 |
4-Aminobenzohydrazide |
4-Aminobenzohydrazide (4-Aminobenzhydrazide, 4-aminobenzoic acid hydrazide, 4-ABAH, Myeloperoxidase Inhibitor I, NSC 640) is an inhibitor of MPO (Myeloperoxidase) enzyme that enhances iNOS induction in MPO-positive cells, but not in MPO-KO cells. |
| S4510 |
4-Aminobenzoic acid |
4-Aminobenzoic acid (para-Aminobenzoic acid) is an intermediate in the synthesis of tetrahydrofolic acid in many non-mammalian organisms, including bacteria and fungi. |
| S4700 |
4-Aminobutyric acid (GABA) |
4-Aminobutyric acid (4-Aminobutanoic acid, GABA, Gamma-aminobutyric acid, Piperidic acid) is a naturally occurring neurotransmitter with central nervous system (CNS) inhibitory activity. |
| S2883 |
4-Aminohippuric Acid |
4-Aminohippuric acid is a typical substrate of organic anion transport systems. |
| S5028 |
4-Aminopyridine |
4-Aminopyridine (4-AP, Fampridine, Dalfampridine) is a potent and non-selective inhibitor of voltage gated potassium channels (Kv) with IC50 values of 170 μM and 230 μM for Kv1.1 and Kv1.2 in CHO cells, respectively.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing. |
| S5211 |
4-Aminosalicylic acid |
4-Aminosalicylic acid (Para-aminosalicylic acid, Aminosalicylic acid, 4-aminosalicylate) is an antitubercular agent with bacteriostatic activity against Mycobacterium tuberculosis. |
| E5779 |
4-Azido-L-phenylalanine |
4-Azido-L-phenylalanine is an unnatural amino acid used as a vibrational probe in protein studies. It contains an azide group and participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions. It also undergoes strain-promoted cycloadditions (SPAAC) with DBCO or BCN-functionalized molecules. |
| E8009 |
4-Azido-L-phenylalanine hydrochloride |
4-Azido-L-phenylalanine hydrochloride is an unnatural amino acid, which is used as an effective vibrational reporter of local protein environments. 4-Azido-L-phenylalanine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. |
| E3086 |
5% Artichoke Leaf EXTRACT |
5% Artichoke Leaf EXTRACT is extracted from Cynara scolymus, which has antioxidant, choleretic, hepatoprotective, bile-enhancing, and lipid-lowering effects. |
| S9366 |
5'-Adenylic acid |
AMP, also known as 5'-Adenylic acid and Adenosine monophosphate, is a nucleotide that is found in RNA. It is used as a dietary supplement to boost immune activity, and is also used as a substitute sweetener to aid in the maintenance of a low-calorie diet. |
| E7207 |
5(6)-Aminofluorescein |
5(6)-Aminofluorescein (5(6)-AFM) is a a precursor for synthesis of 5(6)-FITC (HY-15941). 5(6)-FITC is an amine-reactive derivative of fluorescein dye. |
| S4789 |
5-Acetylsalicylic acid |
5-Acetylsalicylic acid (5-acetyl-2-hydroxybenzoic acid) is a nonsteroidal anti-inflammatory drug. |
| E1087 |
5-amino-2,4-dimethylpyridine (5A-DMP) |
5-amino-2,4-dimethylpyridine (5A-DMP) is a novel tandem Tudor domain (TTD)-binding compound that inhibits the full-length UHRF1:LIG1 interaction in Xenopus egg extracts.
|
| S2553 |
5-Aminolevulinic acid HCl |
5-Aminolevulinic Acid HCl(5-ALA hydrochloride) is an intermediate in the porphyrin synthesis pathway, used as a photosensitizing agent and a antineoplastic agent. |
| S3206 |
5a-Pregnane-3,20-dione |
5a-Pregnane-3,20-dione (5alphaP, 5-a-dihydroprogesterone, 3,20-allopregnanedione, 5-Alpha-Dihydro Progesterone) is the endogenous progesterone metabolite. 5a-Pregnane-3,20-dione depolymerizes actin and decreases expression of actin and vinculin. 5a-Pregnane-3,20-dione is involved in promoting breast neoplasia and metastasis by affecting adhesion and cytoskeletal molecules. |
| S5125 |
5alpha-Cholestan-3-one |
5alpha-Cholestan-3-one (Coprostanone) is a substrate of cholestenone 5alpha-reductase. |
| S4534 |
6-Acetamidohexanoic acid |
6-Acetamidohexanoic acid (6-Acetamidocaproic acid) is a pharmaceutical intermediate. |
| S5035 |
6-Aminopenicillanic acid |
6-Aminopenicillanic acid (6-APA) is the central component of penicillin β-lactam antibiotics which are generated by Penicillium. It is used as precursor for antibiotic compounds ampicillin and amoxicillin. |
| S9783 |
6AN (6-Aminonicotinamide) |
6AN (6-Aminonicotinamide) is an antimetabolite used to inhibit the NADPH-producing pentose phosphate pathway (PPP) in many cellular systems, making them more susceptible to oxidative stress. 6-Aminonicotinamide is a competitive inhibitor of NADP+-dependent enzyme glucose-6-phosphate dehydrogenase (G6PD) with Ki of 0.46 μM. |
| S2530 |
7-Aminocephalosporanic acid |
7-Aminocephalosporanic acid is used for synthesis of cephalosporin antibiotics and intermediates. |
| S6732 |
7ACC2 |
7ACC2 is a potent inhibitor of mitochondrial pyruvate transport 1 (MCT1) with an IC50 value of 10 nM for lactate uptake in SiHa human cervix carcinoma cells. |
| S6082 |
8-Aminooctanoic acid |
8-Aminooctanoic acid is a chemical. |
| E7739 |
8-Azaadenosine |
8-Azaadenosine is a potent inhibitor of ADAR1 and A-to-I editing activity. It blocks RNA editing and inhibits proliferation, 3D growth, invasion, and migration in thyroid cancer cells. |
| E7325 |
9,10-Anthracenediyl-bis(methylene)dimalonic acid |
9,10-Anthracenediyl-bis(methylene)dimalonic acid (ABMDMA) is a biological dye and indicator used to detect singlet oxygen generation (SOG). 9,10-Anthracenediyl-bis(methylene)dimalonic acid is water-soluble derivative of anthracene. 9,10-Anthracenediyl-bis(methylene)dimalonic acid can be photobleached by singlet oxygen to its corresponding endoperoxide. This reaction can be monitored spectrophotometrically by recording the decrease of absorbance at 400 nm. |
| S2653 |
9-amino-CPT (9-Aminocamptothecin) |
9-amino-CPT (9-Aminocamptothecin, 9-AC, Aminocamptothecin, 9-amino-20(S)-camptothecin) is a Topoisomerase I inhibitor with potent anticancer activities. 9-amino-CPT (9-Aminocamptothecin) is an active, water-insoluble derivative of camptothecin. |
| S4303 |
9-Aminoacridine |
9-Aminoacridine (Aminacrine) is a highly fluorescent dye used clinically as a topical antiseptic and experimentally as a mutagen, an intracellular pH indicator and a negative mode small molecule MALDI matrix. |
| E7680 |
A 419259 |
A 419259 (RK-20449) is a selective inhibitor of Src family kinase with IC50 of 9 nM for Src, <3 nM for Lck, and <3 nM for Lyn. It blocks the autophosphorylation of myeloid-specific kinases, disrupting key oncogenic signaling pathways. |
| E7703 |
A 419259 trihydrochloride |
A 419259 trihydrochloride is a Src family kinases inhibitor with IC50s of 9 nM, 3 nM and 3 nM for Src, Lck and Lyn, respectively. |
| E8185 |
A 438079 |
A 438079 is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9. |
| E7789 |
A 839977 |
A 839977 is a P2X7 selective antagonist; it blocks BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7 receptors (IC50 values are 20 nM, 42 nM and 150 nM respectively) and reduces inflammatory and neuropathic pain in animal models; the antihyperalgesic effects of P2X7 receptor blockade are mediated by blocking the release of IL-1beta. |
| E2926 |
A-1155463 |
A-1155463 is a highly potent and selective BCL-XL inhibitor with EC50 of 65 nM in H146 cells. |
| S7800 |
A-1155463 Dihydrochloride |
A-1155463 Dihydrochloride, a highly potent and selective BCL-XL inhibitor, shows picomolar binding affinity to BCL-XL, and >1000-fold weaker binding to BCL-2 and related proteins BCL-W(Ki=19 nM) and MCL-1(Ki>440 nM). |
| S7801 |
A-1331852 |
A-1331852 is a potent and selectiveBCL-XL inhibitor with Ki value less than 0.01 nM for BCL-XL and 6 nM, 4 nM, 142 nM for Bcl-2, Bcl-W, MCL-1 respectively. It may be useful in the treatment of cancer, immune and autoimmune diseases. |
| E2506 |
A-3 hydrochloride |
A-3 hydrochloride, a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases, againsts cAMP-dependent protein kinase (PKA) (Ki=4.3 µM), casein kinase II (CK2) (Ki=5.1 µM) and myosin light chain kinase (MLCK) (Ki=7.4 µM), also inhibits Protein Kinase C (PKC) and casein kinase I (CK1) with Ki values of 47 µM and 80 µM, respectively. |
| S8519 |
A-317491 |
A-317491 is a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors with Ki values of 22 nM and 9 nM for human P2X3 and P2X2/3 receptors. |
| S7572 |
A-366 |
A-366 is a potent and selective G9a/GLP histone lysine methyltransferase inhibitor with IC50 of 3.3nM and 38nM, exhibiting >1000-fold selectivity for G9a/GLP over 21 other methyltransferases. |
| E1125 |
A-443654 |
A-443654, a derivative of indazole–pyridine compounds, is a pan Akt (Akt1, 2, & 3 isoforms) inhibitor which binds to the ATP-binding site of Akt. It is an ATP competitive and reversible inhibitor. |
| E1269 |
A-484954 |
A-484954 is a highly selective eukaryotic elongationfactor-2 kinase(eEF2K) inhibitor, with an IC50 of 280 nM. |
| S8740 |
A-485 |
A-485 is a potent, selective and drug-like p300/CBP catalytic inhibitor with an IC50 of 0.06 μM for p300 HAT. It is selective over BET bromodomain proteins and >150 non-epigenetic targets. |
| E7359 |
A-674563 |
A-674563 is a selective, orally active inhibitor of Akt1 with a Ki of 11 nM. It also inhibits PKA with Ki of 16 nM and CDK2 with Ki of 46 nM. A-674563 reduces Akt downstream target phosphorylation and inhibits tumor cell proliferation in vitro with an EC50 of 0.4 µM. |
| S2670 |
A-674563 HCl |
A-674563 HCl is an Akt1 inhibitor with Ki of 11 nM in cell-free assays, modest potent to PKA and >30-fold selective for Akt1 over PKC. |
| S0826 |
A-740003 |
A-740003 is a potent, selective and competitive antagonist of P2X7 receptor with IC50 of 18 nM and 40 nM for rat and human P2X7 receptors, respectively. A-740003 potently blocks agonist-evoked IL-1β release and pore formation with IC50 of 156 nM and 92 nM in differentiated human THP-1 cells. |
| S2697 |
A-769662 |
A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM in cell-free assays, little effect on GPPase/FBPase activity. |
| E1935 |
A-770041 |
A-770041 is a selective and orally active Src-family Lck inhibitor. A-770041 inhibits Lck with an IC50 value of 147 nM with the presence of 1 mM ATP. A-770041 shows 300-fold selective to Lck over Fyn, the other Src family kinase involved in T-cell signaling. A-770041 can be used for the research of acute rejection. |
| E0039 |
A-779 |
A-779 is a potent and selective antagonist for Angiotensin-(1–7) (Ang-(1-7)) with an IC50 of 0.3 nM in a radioligand binding assay. A-779 shows no significant affinity for AT1 or AT2 receptors at a concentration of 1 μM.
|
| S2785 |
A-803467 |
A-803467 is a selective NaV1.8 channel blocker with IC50 of 8 nM, blocks tetrodotoxin-resistant currents, exhibits >100-fold selectivity against human NaV1.2, NaV1.3, NaV1.5, and NaV1.7. |
| S7692 |
A-83-01 |
A-83-01 is a potent inhibitor of TGF-β type I receptor (ALK5-TD) with IC50 of 12 nM. A-83-01 also inhibits the transcription induced by activin/nodal type I receptor (ALK4-TD) and nodal type I receptor (ALK7-TD) with IC50 of 45 nM and 7.5 nM, respectively.Solutions are unstable and should be fresh-prepared. |
| S2197 |
A-966492 |
A-966492 is a novel and potent inhibitor of PARP1 and PARP2 with Ki of 1 nM and 1.5 nM, respectively. |
| E1890 |
A-967079 |
A-967079 is a selective antagonist of TRPA1 receptor with IC50 values of 67 nM and 289 nM at human and rat TRPA1 receptors, respectively. A-967079 decreases the responses of wide dynamic range (WDR), and nociceptive specific (NS) neurons following noxious pinch stimulation and high-intensity mechanical stimulation in rats. It demonstrates strong penetration into the central nervous system (CNS). |
| A5087 |
A-RAF Rabbit Recombinant mAb |
A-RAF Rabbit Recombinant mAb detects endogenous levels of total A-RAF. |
| F1320 |
A1/Bfl-1 Rabbit mAb |
A1/Bfl-1,BFL-1/GRS |
| S8785 |
A1874 |
A1874 is a much improved nutlin-based, BRD4-degrading PROTAC and is able to degrade its target protein by 98% with nanomolar potency. |
| F3346 |
A20/TNFAIP3 (J7N7) Rabbit mAb |
A20/TNFAIP3,TNFAIP3 |
| F0369 |
A20/TNFAIP3 Rabbit mAb |
A20/TNFAIP3,TNFAIP3 |
| S0741 |
A2764 dihydrochloride |
A2764 dihydrochloride is a selective inhibitor of TRESK (TWIK-related spinal cord K+ channel, K2P18.1) with IC50 of 11.8 μM for the activated mTRESK channel. A2764 dihydrochloride has the potential for probing the role of TRESK channel in migraine and nociception. |
| S0524 |
A2793 |
A2793 (Ethyl [(5-Chloroquinolin-8-yl)oxy]acetate) is an efficient inhibitor of TWIK-related spinal cord potassium channel (TRESK, K2P18, KCNK18) and TASK-1 (KCNK3) with IC50 of 6.8 μM for mouse TRESK. |
| S3408 |
A286982 |
A-286982 is a potent, nonpeptide inhibitor of LFA-1/ICAM-1 interaction with IC50s of 44 nM and 35 nM in an LFA-1/ICAM-1 binding assay and LFA-1-mediated cellular adhesion assay, respectively. |
| E1421 |
A2ti-1 |
A2ti-1 is a selective and high-affinity inhibitor of annexin A2/S100A10 heterotetramer (A2t) with IC50 of 24 μM. A2ti-1 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. It also prevents human papillomavirus type 16 (HPV16) infection. |
| E1436 |
A2ti-2 |
A2ti-2 is a selective and low-affinity inhibitor of annexin A2/S100A10 heterotetramer (A2t)with an IC50 of 230 μM. It specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10 and also prevents human papillomavirus type 16 (HPV16) infection. |
| S2674 |
A922500 |
A922500 (DGAT-1 Inhibitor 4a) is an inhibitor for human and mouse DGAT-1 with IC50 of 7 nM and 24 nM, respectively, good selectivity over related acyltransferases, hERG, and a panel of anti-targets. |
| S9607 |
A939572 |
A939572 is a potent and orally bioavailable stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50 of <4 nM and 37 nM for mSCD1 and hSCD1, respectively. |
| E0745 |
AA147 |
AA147, a small molecule endoplasmic reticulum (ER) proteostasis regulator, selectively activates ATF6 arm of the unfolded protein response (UPR) extracted from patent WO2017117430A1, compound 147*. |
| S0286 |
AA26-9 |
AA26-9 is a potent and broad spectrum inhibitor of Serine hydrolases (SHs). |
| E0409 |
AA38-3 |
AA38-3, a serine hydrolase (SH) inhibitor, can inhibit three SHs, ABHD6, ABHD11, and FAAH. |
| S3415 |
AA92593 |
AA92593 is a selective antagonist of Melanopsin (OPN4) which is a photo-pigment found in a small subset of intrinsically photosensitive ganglion cells (ipRGCs) of the mammalian retina. |
| E1116 |
AACOCF3 |
AACOCF3 (Arachidonyl trifluoromethyl ketone) is an inhibitor of cytosolic phospholipase A2 (cPLA2) and calcium-independent phospholipase A2(iPLA2) with IC50 of 1.5 μM and 6.0 μM, respectively. It inhibits aortic osteoinductive signalling and vascular calcification in the cholecalciferol-overload mouse model. |
| S0038 |
AB-423 |
AB-423, a member of the sulfamoylbenzamide (SBA) class of hepatitis B virus (HBV) capsid inhibitors, shows potent inhibition of HBV replication with EC50 of 0.08 μM - 0.27 μM and EC90 of 0.33 μM - 1.32 μM in cells. Phase 1. |
| S8908 |
AB680 |
AB-680 is a highly potent, reversible and selective inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73. |
| S5215 |
Abacavir |
Abacavir is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. |
| S3165 |
Abacavir sulfate |
Abacavir (1592U89) is a commonly used nucleoside analogue with potent antiviral activity against HIV-1. |
| P1092 |
Abaloparatide (BA058) |
Abaloparatide (BA058, BIM-44058, ITM-058) is a novel 34-amino acid peptide selected to be a potent and selective activator of the parathyroid hormone receptor (PTH1R) signaling pathway with an IC50 of 0.117 nM in SOST analysis.
|
| S5752 |
Abametapir |
Abametapir (HA-44, BRN 0123183), the active ingredient of Xeglyze Lotion, is an inhibitor of metalloproteinases critical for louse survival and egg development. |
| P1142 |
Abarelix |
Abarelix (R3827; PPI 149) is a potent gonadotrophin-releasing hormone (GnRH) antagonist, used for prostate cancer treatment.
|
| P1005 |
Abarelix Acetate |
Abarelix Acetate is a potent gonadotrophin-releasing hormone (GnRH) antagonist, used for prostate cancer research. |
| S8723 |
ABBV-744 |
ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2, BRD3 and BRD4. It is developed for treating AML and cancers. |
| E8306 |
ABBV-969 Payload |
ABBV-969 Payload is an agent-linker conjugate with a potent inhibitor of topoisomerase I and a linker designed for use in the antibody-drug conjugate (ADC) ABBV-969. It can be used in non-small cell lung cancer research. |
| A5343 |
ABCF1 Rabbit Recombinant mAb |
ABCF1 Rabbit Recombinant mAb detects endogenous level of total ABCF1. |
| F1575 |
ABCG1 Rabbit mAb |
|
| F0718 |
ABCG2 Rabbit mAb |
ABCG2,BCRP/ABCG2,BCRP1,CD338 |
| E8291 |
ABD0171 |
ABD0171 is a potent, irreversible, and selective inhibitor of aldehyde dehydrogenase 1A3 (ALDH1A3), with an IC50 of 0.34 µM using the physiological substrate all-trans-retinaldehyde (atRAL). It also inhibits ALDH1A2 and ALDH1A1 with IC50 of 0.79 µM and 6.6 µM, respectively. ABD0171 disrupts key oncogenic pathways in triple-negative breast cancer (TNBC) cells in vitro and exhibits robust antitumor and antimetastatic activity in vivo. |
| S5716 |
Abemaciclib |
Abemaciclib is a cell cycle inhibitor selective for CDK4/6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively. |
| S7158 |
Abemaciclib mesylate |
Abemaciclib mesylate is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively. Phase 3. |
| E8068 |
Abemaciclib metabolite M2 |
Abemaciclib metabolite M2 (LSN2839567) is a metabolite of Abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s of 1.2 and 1.3 nM, respectively. Anti-cancer activity. |
| S8689 |
Abequolixron (RGX-104) |
Abequolixron (RGX-104) is a orally bioavailable liver X receptor agonist that modulates innate immunity via transcriptional activation of the ApoE gene. |
| S1090 |
Abexinostat (PCI-24781) |
Abexinostat (PCI-24781, CRA-024781) is a novel pan-HDAC inhibitor mostly targeting HDAC1 with Ki of 7 nM, modest potent to HDACs 2, 3, 6, and 10 and greater than 40-fold selectivity against HDAC8. Phase 1/2. |
| S5122 |
Abietic Acid |
Abietic acid (Sylvic acid, Abietate, Rosin Acid), an abietane diterpenoid, inhibited soybean 5-lipoxygenase with an IC50 of 29.5 ± 1.29 μM. |
| S1123 |
Abiraterone |
Abiraterone is a potent CYP17 inhibitor with IC50 of 2 nM in a cell-free assay. Abiraterone (CB-7598) is an androgen biosynthesis inhibitor. |
| S2246 |
Abiraterone Acetate |
Abiraterone Acetate is an acetate salt form of Abiraterone which is a steroidal cytochrome CYP17 inhibitor with IC50 of 72 nM in a cell-free assay. Abiraterone acetate is an oral androgen biosynthesis inhibitor. |
| F2357 |
ABL1 Rabbit mAb |
ABL,ABL1,c-Abl |
| E1134 |
ABR-238901 |
ABR-238901 is a novel S100A8/A9 blocker that potently inhibits S100A8/A9 interaction with its receptors RAGE (receptor for advanced glycation endproducts) and TLR4 (toll-like receptor 4). |
| A2761 |
Abrilumab (Anti-Integrin a4b7 ITGA4 & ITGB7) |
Abrilumab (Anti-Integrin a4b7 ITGA4 & ITGB7) is a fully human monoclonal immunoglobulin G2 antibody that targets the alpha4beta7 integrin and prevents interaction with MADCAM-1. It has the potential to be used in research on inflammatory bowel disease (IBD). MW: 143.8 kD. |
| S8765 |
Abrocitinib (PF-04965842) |
Abrocitinib (PF-04965842) is a potent JAK1 inhibitor with IC50s of 29 nM, 803 nM, > 10 000 nM and 1250 nM for JAK1, JAK2, JAK3 and tyrosine kinase (TYK) 2, respectively. |
| E3351 |
Abrus mollis Extract |
Abrus mollis Extract is extracted from Abrus mollis, which is used as a folk beverage and soups that are good to cleanse liver toxicants and prevent liver diseases. |
| S7594 |
Abscisic Acid (Dormin) |
Abscisic Acid (Dormin, Abscisin II) is a plant hormone, which is involved in many plant developmental processes, modulates ion homeostasis and metabolism, and inhibits germination and seedling growth.
|
| S6619 |
ABT 702 dihydrochloride |
ABT-702 is a novel, potent non-nucleoside Adenosine kinase inhibitor with an IC50 of 1.7 nM. It has oral activity in animal models of pain and inflammation. |
| A4020 |
Abt-122 (Anti-IL-17 & TNF-alpha) |
Abt-122 is a dual variable domain immunoglobulin (DVD-Ig) that targets human TNF and IL-17A, with the potential to treat rheumatoid arthritis (RA). MW: 198.74 KD. |
| E8015 |
ABT-239 |
ABT-239 is a novel, highly efficacious, non-imidazole class of H3R antagonist and a transient receptor potential vanilloid type 1 (TRPV1) antagonist. |
| E7858 |
ABT-639 |
ABT-639 is a novel, peripherally acting, selective T-type Ca2+ channel blocker. |
| S1002 |
ABT-737 |
ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1. ABT-737 induces mitochondrial pathway apoptosis and mitophagy. Phase 2. |
| S1165 |
ABT-751 (E7010) |
ABT-751 (E7010) binds to the colchicine site on β-tubulin and inhibits polymerization of microtubules, not a substrate for the MDR transporter and is active against cell lines resistant to vincristine, doxorubicin, and cisplatin. Phase 1/2. |
| S9611 |
ABTL-0812 |
ABTL0812 (α-Hydroxylinoleic acid, LP-10218, SCLN-0812) inhibits Akt/mTOR axis by inducing the overexpression of TRIB3 and activating autophagy in lung squamous carcinoma cell lines. ABTL0812 also induces AMPK activation and ROS accumulation. |
| E2917 |
ABTS |
ABTS (ABTS diammonium salt, AzBTS-(NH4)2) is a substrate for horseradish peroxidase (HRP) conjugate. It has commonly been used to assess antioxidant capacity in the Trolox equivalent antioxidant capacity (TEAC) assay. |
| S8823 |
ABX-1431 |
ABX-1431 is a highly potent, selective, and CNS-penetrant Monoacylglycerol lipase (MGLL) inhibitor with IC50 values of 14 nM and 27 nM for hMGLL and mMGLL respectively. |
| S0076 |
ABX464 |
ABX464 (SPL-464) is a novel anti-HIV molecule that inhibits HIV-1 replication in stimulated peripheral blood mononuclear cells (PBMCs) from 5 different donors with IC50 ranging between 0.1 μM and 0.5 μM. |
| E8101 |
AC-262536 |
AC-262536 is a selective and non-steroidal androgen receptor modulators (SARMs) with beneficial anabolic effects. AC-262536 exhibits potent agonist activity at the androgen receptor, with an affinity in the low nanomolar range (1-10 nM). |
| E8024 |
AC-55541 |
AC-55541 is a highly selective protease-activated receptor 2 (PAR2) agonist (pEC50=6.7), displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. AC-55541 has pEC50 values of 5.9 and 6.6 in PI hydrolysis assays and Ca2+ mobilization assays and exhibits pronociceptive activity in vivo. |
| S6354 |
Ac-Arg-OH |
Ac-Arg-OH (N-Acetyl-L-arginine) is one of the guanidino compounds found elevated in the serum of an hemodialyzed renal insufficient (uremic) pediatric population. |
| E7016 |
Ac-DEVD-AFC |
Ac-DEVD-AFC is a fluorogenic substrate specifically measures the activity of caspase-3, a key protease involved in apoptosis. |
| E7032 |
Ac-DEVD-AMC |
Ac-DEVD-AMC is a fluorescent substrate of caspase-3/caspase-7. When treating Ac-DEVD-AMC with cell lysate, Ac-DEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection, with an excitation wavelength of 380 nm and an emission wavelength of 460 nm. |
| S7901 |
Ac-DEVD-CHO |
Ac-DEVD-CHO (Caspase-3 Inhibitor I, N-Ac-Asp-Glu-Val-Asp-CHO) is a potent aldehyde inhibitor of Group II caspases with Ki values of 0.2 nM and 0.3 nM for for caspase-3 and caspase-7, respectively. Weak inhibition for caspase-2. |
| S9817 |
Ac-FLTD-CMK |
Ac-FLTD-CMK is a specific inhibitor for inflammatory caspases. Ac-FLTD-CMK inhibits gasdermin D (GSDMD) cleavage by caspases-1, -4, -5, and -11 in vitro. Ac-FLTD-CMK is effective against caspases-1, caspases-4 and caspases-5 with IC50 of 46.7 nM, 1.49 μM and 329 nM, respectively. |
| E7402 |
Ac-IETD-AFC |
Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B. |
| E7403 |
Ac-LEHD-AFC |
Ac-LEHD-AFC is a fluorescent substrate for caspase-9, can be used to assess the activity of caspase. |
| E7223 |
Ac-YVAD-AFC |
Ac-YVAD-AFC is the the fluorometric peptide substrate of caspase-1, with λ excitation of 400 nm and λ emission of 505 nm. |
| S9727 |
Ac-YVAD-cmk |
Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective IL-1β converting enzyme (ICE) inhibitor with neuroprotective and anti-inflammatory effects, effectively suppresses the expression of IL-1β and IL-18. |
| S0977 |
AC1903 |
AC1903 (compound 2) is a specific and selective TRPC5 (transient receptor potential canonical channel 5) inhibitor with IC50 of 4.06 μM. |
| E7684 |
Ac2-26 |
Ac2-26, an active N-terminal peptide of annexin A1 (AnxA1), attenuates ischemia-reperfusion-induced acute lung injury. Ac2-26 also decreases AnxA1 protein expression, inhibits the activation of NF-κB and MAPK pathways in the injured lung tissue. |
| S1056 |
AC480 (BMS-599626) |
AC480 (BMS-599626) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, ~8-fold less potent to HER4, >100-fold to VEGFR2, c-Kit, Lck, MET etc. Phase 1. |
| E7558 |
Ac4ManNAz (80% α isomer) |
Ac4ManNAz is an azido-containing metabolic glycoprotein labeling reagent. Ac4ManNAz can be used to selectively modify proteins. Ac4ManNAz can be used in cell labeling, tracking and proteomic analysis. Ac4ManNAz is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. |
| S5318 |
Acacetin |
Acacetin (Linarigenin, 5,7-dihydroxy-4'-methoxyflavone, 4'-Methoxyapigenin) is a flavonoid compound that has been shown to have anti-cancer, anti-mutagenic, anti-inflammatory and anti-peroxidative effects. |
| E3353 |
Acacia Farnesiana Extract |
Acacia Farnesiana Extract is extrcated from Acacia Farnesiana, which acts against M. tuberculosis and dysentery bacteria. |
| A5498 |
ACADM Rabbit Recombinant mAb |
ACADM Rabbit Recombinant mAb detects endogenous level of total ACADM. |
| F2413 |
ACADM/MCAD Rabbit mAb |
|
| S8116 |
Acalabrutinib (ACP-196) |
Acalabrutinib (ACP-196) is a selective second-generation Bruton's tyrosine kinase (BTK) inhibitor with an IC50 of 3 nM, which prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. ACP-196 has improved target specificity with 323-, 94-, 19- and 9-fold selectivity over the other TEC kinase family members (ITK, TXK, BMX, and TEC, respectively) and no activity against EGFR. |
| S5818 |
acalisib (GS-9820) |
Acalisib (GS-9820, CAL-120) is a highly selective and potent p110δ inhibitor (IC50 = 14 nM) with 114- to 400-fold selectivity over the other class I PI3K enzymes and no activity against Class II and III PI3K family members or other PI3K-related proteins including mTOR and DNA-PK. |
| S3748 |
Acamprosate Calcium |
Acamprosate (N-Acetylhomotaurine, Calcium acetylhomotaurinate,N-acetylhomotaurinate) is a synthetic compound with a chemical structure similar to the amino acid neurotransmitter gamma-aminobutyric acid (GABA) and the amino acid neuromodulator taurine. |
| E3116 |
Acanthopanax Senticosus Extract |
Acanthopanax Senticosus Extract is obtained from Acanthopanax Senticosus, which exhibits dual effects of contraction via muscarinic ACh receptors (mAChRs) and direct relaxation on mouse ileal function, and its relaxant effect could be useful in treating diarrhea symptoms, resulting in an increase in the parasympathetic nerve activities. |
| S1271 |
Acarbose |
Acarbose(BAY g 5421,Prandase, Precose, Glucobay, Bay-g 5421) is an inhibitor of intestinal alpha-glucosidase, used to treat type 2 diabetes mellitus. |
| A4055 |
Acasunlimab (Anti-4-1BB & PD-L1) |
Acasunlimab is a recombinant Fc-silenced IgG1 bispecific antibody targeting PD-L1 and 4-1BB, with checkpoint inhibitory, immunostimulating, and antineoplastic activities. It enhances antitumor immune response by enabling conditional 4-1BB activation strictly dependent on PD-L1 binding. M.W 144.3 kDa |
| F2925 |
ACAT1 Rabbit mAb |
|
| S9612 |
ACBI1 |
ACBI1 is a potent and cooperative PROTAC degrader of SMARCA2, SMARCA4 and PBRM1 with DC50 of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 induces anti-proliferative effects and apoptosis. |
| E4758 |
ACBI3 |
ACBI3 is a selective and potent PROTAC degrader of pan-KRAS that promotes VHL engagement, ternary complex formation, and E3 ligase-dependent KRAS degradation with high proteome-wide selectivity. It demonstrates strong anti-tumor activity, resulting in durable pathway modulation and tumor regressions in KRAS driven cancers. |
| A5552 |
ACC1 Rabbit Recombinant mAb |
ACC1 Rabbit Recombinant mAb detects endogenous level of total ACC1. |
| A5924 |
ACE1 Rabbit Recombinant mAb |
ACE1 Rabbit Recombinant mAb detects endogenous levels of total ACE1. |
| F1542 |
ACE2 Rabbit mAb |
ACE2,ACE-2 |
| S4010 |
Acebutolol HCl |
Acebutolol is a β-adrenergic receptors antagonist used in the treatment of hypertension, angina pectoris and cardiac arrhythmias. |
| S4835 |
Aceclofenac |
Aceclofenac (Preservex, Airtal) is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. |
| F0568 |
AceCS1 Rabbit mAb |
AceCS1,ACSS2 |
| S4512 |
Aceglutamide |
Aceglutamide (α-N-Acetyl-L-glutamine, N2-Acetylglutamine) is a psychostimulant, nootropic agent which functions as a prodrug to glutamine with improved potency and stability. |
| S9649 |
Acelarin (NUC-1031) |
Acelarin (NUC-1031, CPF-31, MTL-007, GTPL7389) is a DNA synthesis inhibitor with EC50 of 0.2 nM. |
| S2602 |
Acemetacin |
Acemetacin (K-708,TVX 1322) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor. |
| S2884 |
Acesulfame Potassium |
Acesulfame potassium is a non-nutritive sweetener. |
| E1722 |
Acetalax(Oxyphenisatin acetate) |
Oxyphenisatin acetate is the pro-drug of oxyphenisatin. It has antiproliferative activity and also used to be a laxative. |
| S6011 |
Acetamide |
Acetamide (ethanamide, Acetic acid amide) is an organic compound that can be used as a plasticizer and an industrial solvent. |
| S1634 |
Acetaminophen |
Acetaminophen is a COX inhibitor for COX-1 and COX-2 with IC50 of 113.7 μM and 25.8 μM, respectively. |
| S4506 |
Acetazolamide |
Acetazolamide (Diamox), a potent carbonic anhydrase (CA) inhibitor, is commonly used in clinical practice as an immediate and readily available option for acute reduction of intraocular pressure(IOP). |
| E6058 |
Acetazolamide sodium |
Acetazolamide sodium is an inhibitor of carbonic anhydrase (CA) IX with an IC50 of 30 nM for hCA IX and also inhibits hCA II with an IC50 of 13 nM. It possesses diuretic, antihypertensive, and anti-gonococcal properties. |
| S2999 |
Acetic acid octyl ester |
Acetic acid octyl ester (Octyl acetate) is one of the major components of essential oils in the vittae, or oil tubes, of the wild parsnip (Pastinaca sativa). Acetic acid octyl ester exhibits antioxidant activity. |
| E7516 |
Acetoacetic acid sodium |
Acetoacetic acid sodium is an oxidative stress inducer that acts via reducing the mRNA expression and activities of antioxidant enzymes (SOD, CAT, GSH-Px) and increasing malondialdehyde (MDA) levels. It is a signaling molecule that may influence very low density lipoprotein (VLDL) assembly in bovine hepatocytes and contribute to the development of human diabetes. |
| S5717 |
Acetohexamide |
Acetohexamide is an intermediate-acting, first-generation oral sulfonylurea with hypoglycemic activity. It exerts the blood-glucose-lowering effects by stimulating the pancreatic beta cells to secrete insulin and by helping the body use insulin efficiently. |
| S4602 |
Acetohydroxamic acid |
Acetohydroxamic acid is an Urease Inhibitor. In the urine, it acts as an antagonist of the bacterial enzyme urease. |
| S5528 |
Acetophenone |
Acetophenone (Methyl phenyl ketone, Phenylethanone) is an organic compound used as fragrances and a raw material for the synthesis of some pharmaceuticals. |
| E8229 |
acetophenone-d8 |
Acetophenone D8 is the deuterated form of acetophenone. Acetophenone is an organic compound used as a flavoring agent and is also a raw material for the synthesis of some drugs. |
| S4955 |
Acetosyringone |
Acetosyringone (Acetosyringenin) is a phenolic natural product with analgesic, antipyretic and anti-inflammatory actions. |
| E4478 |
Acetrizoic acid |
Acetrizoic acid is a first monomeric, water-soluble, iodinated ionic compound used as an X-ray contrast agent having nephrotropic property that can be intravenously administered for clinical applications. |
| E7088 |
Acetyl Coenzyme A trisodium |
Acetyl Coenzyme A trisodium is a membrane-impermeant central metabolic intermediate involved in the TCA cycle and oxidative phosphorylation. It serves as a critical link between carbohydrate, fatty acid, and amino acid metabolism and acts as the sole acetyl group donor for protein acetylation, regulating cellular processes including autophagy via the acetyltransferase EP300. |
| E5841 |
Acetyl phosphate(lithium potassium) |
Acetyl phosphate(lithium potassium) is an endogenous metabolite, bypasses the LytS membrane potential sensor by phosphorylating LytR twice as fast, influencing lrgAB operon regulation in glucose-rich conditions without membrane potential disruption. Lithium potassium acetyl phosphate is studied for its electrochemical properties and role in phosphorus chemistry, with potential applications in lithium-ion battery technology and catalytic processes. |
| S3934 |
Acetyl Resveratrol |
Acetyl Resveratrol is the derivative compound of resveratrol, which is a potent phenolic antioxidant found in grapes and red wine. |
| F0270 |
Acetyl-CoA Carboxylase Rabbit mAb |
Acetyl-CoA carboxylase 1, Acetyl-Coenzyme A carboxylase alpha, ACC1, ACC-alpha, ACC α, ACACA, ACAC, ACCA, ACC-beta, ACC β, ACACB, ACC2, ACCB, Acetyl-CoA carboxylase 2 |
| F2111 |
Acetyl-Histone H3 (Lys 14) Rabbit mAb |
|
| F2787 |
Acetyl-Histone H3 (Lys 4) Rabbit mAb |
|
| F2950 |
Acetyl-Histone H3 (Lys 9) (N12G4) Rabbit mAb |
Acetyl-Histone H3 (Lys9),Ac-Histone H3,Histone H3 (acetyl K9) |
| F0319 |
Acetyl-Histone H3 (Lys 9) Rabbit mAb |
Acetyl-Histone H3 (Lys9),Ac-Histone H3,Histone H3 (acetyl K9) |
| F0669 |
Acetyl-Histone H3 (Lys18) Rabbit mAb |
Acetyl-Histone H3 (Lys18),Histone H3 (acetyl K18) |
| F0271 |
Acetyl-Histone H3 (Lys27) Rabbit mAb |
Acetyl Histone H3 (Lys27),Acetyl-Histone H3 (Lys27),Histone H3 (acetyl K27) |
| F2462 |
Acetyl-Histone H4 (Lys 8) Rabbit mAb |
Acetyl-Histone H4 (Lys8),Histone H4 (acetyl K8) |
| F0826 |
Acetyl-Histone H4 (Lys12) Rabbit mAb |
Acetyl-Histone H4 (Lys12),Histone H4 (acetyl K12) |
| F1619 |
Acetyl-SOD2/MnSOD (Lys 68) Rabbit mAb |
|
| F0620 |
Acetyl-α-Tubulin (Lys40) Rabbit mAb |
acetyl-alpha tubulin,Acetyl-alpha Tubulin (Lys40),Acetylated Tubulin,Acetyl-α-Tubulin (Lys40),alpha Tubulin (acetyl K40),alpha Tubulin acetyl K40,Tubulin, Acetylated |
| S1805 |
Acetylcholine Chloride |
The chemical compound Acetylcholine Chloride(ACh chloride) is a neurotransmitter in both the peripheral nervous system (PNS) and central nervous system (CNS) in many organisms including humans. |
| S4718 |
Acetylcholine iodide |
Acetylcholine iodide (Acetylcolina) is a neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. |
| F2495 |
Acetylcholinesterase Rabbit mAb |
|
| S3269 |
Acetylcorynoline |
Acetylcorynoline, a major alkaloid component derived from Corydalis bungeana which is a traditional Chinese medical herb, shows anti-inflammatory properties. Acetylcorynoline may decrease egl-1 expression to suppress apoptosis pathways and increase rpn5 expression to enhance the activity of proteasomes. |
| S1623 |
Acetylcysteine (N-acetylcysteine) |
Acetylcysteine (N-acetyl-l-cysteine, NAC,N-acetylcysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor. Acetylcysteine(N-acetyl-l-cysteine) suppresses TNF-induced NF-κB activation through inhibition of IκB kinases. Acetylcysteine(N-acetyl-l-cysteine) induces apoptosis via the mitochondria-dependent pathway. Acetylcysteine(N-acetyl-l-cysteine) inhibits ferroptosis and virus replication.Solutions are unstable and should be fresh-prepared. |
| S5201 |
Acetylisovaleryltylosin Tartrate |
Acetylisovaleryltylosin tartrate (AK105039) is an antimicrobial of the macrolide group with antibacterial activity against Gram-positive bacteria. |
| S4514 |
Acetylleucine |
Acetylleucine (N-acetyl-L-leucine) is a drug used in the treatment of vertigo. |
| S3618 |
Acetylspiramycin (ASPM) |
Acetylspiramycin (ASPM, Spiramycin II, Foromacidin B) is a macrolide antimicrobial agent.
|
| E2998 |
Acetylthiocholine iodide |
Acetylthiocholine iodide(S-Acetylthiocholine iodide; ATCh iodide) is used as a substrate in the preparation of acetylcholine esterase (AChE) assay working solution for AChE activity assay. In addition, the compound is used in some medical research, for example in the fields of neuroscience and organ physiology. |
| S3976 |
Acetylvanillin |
Acetylvanillin (Acetovanillin, Vanillin acetate, 4-Acetoxy-3-methoxybenzaldehyde, 4-Formyl-2-methoxyphenyl acetate), is found in pulses and is a flavouring material. |
| E0244 |
Acevaltrate |
Acevaltrate, an active component derived from the herbal plant Valeriana jatamansi Jones, is strikingly potent to induce GBM cell apoptosis. Acevaltrate inhibits the Na+/K+-ATPase activity in the rat kidney and brain hemispheres with IC50 of 22.8 μM and 42.3 μM, respectively. |
| E3529 |
Achillea millefolium Extract |
Achillea Millefolium Extract is extracted from Achillea millefolium, which has protective effect against the complications of diabetes mellitus. |
| E1278 |
ACHP Hydrochloride |
ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective IKK-β inhibitor with an IC50 of 8.5 nM. |
| E3303 |
Achyranthes bidentata Blume root Extract |
Achyranthes Bidentata Blume Root Extract, isolated from the dried roots of Achyranthes bidentata Blume, has a beneficial effect on inhibition of adipogenesis and controlling body weight in rats fed with a high-fat diet. |
| E3522 |
Achyranthes bidentata root Extract |
Achyranthes Bidentata Root Extract is extracted from the roots of Achyranthes bidentata, which can be a treatment for postmenopausal osteoporosis. |
| S6158 |
Acid orange 7 |
Acid orange 7 (2-naphthol orange, Orange II, CI 15510, D&C Orange 4, COLIPA C015) is an azo dye used for dyeing wool. |
| S6152 |
Acid Red 27 |
Acid Red 27 (Azorubin S, Amaranth) is a modified red azo dye used as a food dye and to color cosmetics. |
| S6064 |
Acid Yellow 23 |
Acid Yellow 23 is a popular colorant for multiple applications, commonly used in ink, pond dyes, and textiles. |
| S6189 |
Acid Yellow 36 |
Acid Yellow 36 (Metanil Yellow) is a dye of the azo class and used as a pH indicator and it has a color change from red to yellow between pH 1.2 and 2.3. |
| S1806 |
Acipimox |
Acipimox (Olbemox,K-9321) is a niacin derivative used as a hypolipidemic agent. |
| S1368 |
Acitretin |
Acitretin (Etretin, RO 10-1670) is a second generation retinoid used for psoriasis. |
| E7988 |
Aclacinomycin A hydrochloride |
Aclacinomycin A (Aclarubicin) hydrochloride is an orally active and potent anthracycline antitumor antibiotic. Aclacinomycin A hydrochloride is an inhibitor of topoisomerase I and II. Aclacinomycin A hydrochloride inhibits synthesis of nucleic acid, especially RNA. Aclacinomycin A hydrochloride might inhibit the 26S protease complex as well as the ubiquitin-ATP-dependent proteolysis. |
| S4031 |
Aclidinium Bromide |
Aclidinium Bromide (LAS 34273, LAS-W 330) inhibits human muscarinic AChR M1, M2, M3, M4 and M5 with Ki of 0.1 nM, 0.14 nM, 0.14 nM, 0.21 nM and 0.16 nM, respectively. |
| E3555 |
Acmella oleracea Extract |
Acmella Oleracea Extract is extracted from Acmella Oleracea, which can decrease chymase activity, oxidative stress, and inflammation. |
| A5494 |
Aconitase 1 Rabbit Recombinant mAb |
Aconitase 1 Rabbit Recombinant mAb detects endogenous level of total Aconitase 1. |
| E3637 |
Acorus tatarinowii Extract |
Acorus Tatarinowii Extract is extracted from Acorus Tatarinowii, which can be used in the treatment of Alzheimer's disease. |
| S5075 |
Acotiamide |
Acotiamide (Acofide, Z388) is a novel acetylcholinesterase inhibitor with fundus-relaxing and gastroprokinetic properties. |
| S4838 |
Acotiamide hydrochloride |
Acotiamide Hydrochloride (YM-443, Z-338) is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. It is a new orally active selective acetylcholinesterase inhibitor. |
| F2438 |
ACOX1/AOX Rabbit mAb |
ACOX1,ACOX1/AOX |
| S0839 |
ACP-105 |
ACP-105 is an orally available and potent selective androgen receptor modulator (SARM) with pEC50 of 9.0 and 9.4 for AR wild type and AR mutation T877A, respectively. |
| E7555 |
Acridine Orange 10-Nonyl Bromide |
Acridine Orange 10-Nonyl Bromide (Nonylacridine orange) is a mitochondrial-specific fluorescent probe with an absorption wavelength of 489 nm and an emission wavelength of 525 nm, commonly used in flow cytometry to study mitochondrial properties. It's binding is unaffected by uncouplers, ionophores, or nucleases, making it a stable and reliable tool for cellular research. |
| E7809 |
Acridine Orange base |
Acridine Orange base is a cell-permeable fluorescent dye that stains organisms (bacteria, parasites, viruses, etc.) bright orange and, when used under appropriate conditions (pH=3.5, Ex=460 nm), distinguishes human cells in green for detection by fluorescence microscopy. Acridine Orange base fluoresces green when bound to dsDNA (Ex=488, Em=520-524) and red when bound to ssDNA (Ex=457, Em=630-644) or ssRNA (Ex=457, Em=630-644), also can be used in cell cycle assays. |
| E1838 |
Acridine Orange hydrochloride |
Acridine Orange hydrochloride is a cell-penetrable nucleic acid-selective fluorescent dye. Acridine Orange hydrochloride produces orange fluorescence when it binds to ssDNA or RNA, and green fluorescence when it binds to dsDNA (Ex: 488 nM; Em: green fluorescence at 530 nm, orange fluorescence at 640 nm). |
| S8617 |
Acriflavine |
Acriflavine is a HIF-1 dimerization inhibitor and have potent inhibitory effects on tumor growth and vascularization. It is used as fluorescent dye for labeling high molecular weight RNA. |
| S5718 |
Acrivastine |
Acrivastine(BW825C) is an antihistamine medicine that relieves the symptoms of allergies. |
| F0872 |
ACSL1 Rabbit mAb |
|
| S8588 |
ACSS2 inhibitor |
ACSS2 inhibitor is the most potent and specific inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2). ACSS2 inhibitor also inhibits the respiratory syncytial virus (RSV). |
| E1941 |
ACT-1016-0707 |
ACT-1016-0707 (LPA1 receptor antagonist 2) is an orally active and selective antagonist of LPA1 Receptor, with IC50 of 3.1 nM for hLPAR1 in tango assay. It has the potential to treat fibrotic diseases. |
| F0082 |
Actin Rabbit mAb |
Actin,Actin Ab-5,pan Actin,Pan-Actin |
| S8964 |
Actinomycin D (Dactinomycin) |
Actinomycin D (Dactinomycin, Act D, RASP-101) is a significant polypeptide antibiotic isolated from soil bacteria of the genus Streptomyces. Actinomycin D (Dactinomycin) inhibits DNA repair and rests the cell cycle at G1 phase with IC50 of 0.42 μM and 0.4 nM, respectively. Actinomycin D is an autophagy activator, induces p53-independent cell death and prolongs survival in high-risk chronic lymphocytic leukemia.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing. |
| E7845 |
Actinomycin X2 |
Actinomycin X2 (Actinomycin V), produced by many Streptomyces sp., shows strong inhibition of MRSA with a minimum inhibitory concentration (MIC) value of 0.25 μg/mL. Actinomycin X2 can be used for cancer and bacterial infection. |
| E7617 |
Activated Protein C (390-404), human |
Activated Protein C (390-404), human is a peptide of the activated protein C (a vitamin K-dependent serine protease), potently inhibits APC anticoagulant activity. |
| E8063 |
Acumapimod |
Acumapimod (BCT197) is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 μM for p38α. |
| A5397 |
ACVRL1 Rabbit Recombinant mAb |
ACVRL1 Rabbit Recombinant mAb detects endogenous level of total ACVRL1. |
| S8648 |
ACY-738 |
ACY-738 inhibits HDAC6 with low nanomolar potency (IC50=1.7 nM) and a selectivity of 60- to 1500-fold over class I HDACs. |
| S0864 |
ACY-775 |
ACY-775 is a potent and selective histone deacetylase 6 (HDAC6) inhibitor with IC50 of 7.5 nM. |
| E7940 |
ACY-957 |
ACY-957 is a selective chemical inhibitor of HDAC1 and HDAC2 with an IC50 values of 7 nM, 18 nM against HDAC1/2 respectively. It induces hemoglobin protein (HbF) in primary erythroid progenitor cells, including those from sickle cell patients, offering a promising approach for treating sickle cell disease (SCD) and β-thalassemia. |
| S1807 |
Acyclovir (Aciclovir) |
Acyclovir (Aciclovir) is a synthetic nucleoside analogue active against herpesviruses. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells. |
| E1931 |
AD-5584 |
AD-5584 is a specific inhibitor of human acyl-CoA synthetase short chain family member 2 (ACSS2). It significantly reduces lipid storage, decreases colony formation, and increases cell death in vitro, while also confirming blood-brain barrier (BBB) permeability. |
| E1930 |
AD-8007 |
AD-8007 is a selective and brain-penetrant inhibitor of acetyl CoA synthase 2 (ACSS2). AD-8007 significantly reduces lipid storage, cell colony formation, acetyl-CoA levels and cell survival in vitro models, and increase tumor cell death, tumor burden and increases survival in in-vivo models. AD-8007 exhibits anti-cancer activity. |
| S8518 |
AD80 |
AD80, a multikinase inhibitor, shows strong activity against human RET (c-RET), BRAF, S6K, and SRC but were much less active than either AD57 or AD58 against mTOR. The IC50 value for RET is 4 nM. |
| S8884 |
Adagrasib (MRTX849) |
Adagrasib (MRTX849) is a potent, selective, and covalent KRASG12C inhibitor that exhibits favorable drug-like properties, selectively modifies mutant cysteine 12 in GDP-bound KRASG12C and inhibits KRAS-dependent signaling. |
| A2010 |
Adalimumab (anti-TNF-alpha) |
Adalimumab (anti-TNF-alpha) is the first fully human, recombinant IgG1 monoclonal antibody that specifically targets human TNF-alpha, MW: 144.19 KD. |
| F3680 |
ADAM10 Rabbit mAb |
ADAM 10,ADAM10 |
| A5298 |
ADAM10 Rabbit Recombinant mAb |
ADAM10 Rabbit Recombinant mAb detects endogenous level of total ADAM10. |
| A5559 |
ADAM17 Rabbit Recombinant mAb |
ADAM17 Rabbit Recombinant mAb detects endogenous level of total ADAM17. |
| S2869 |
Adamantane |
Adamantane is a colorless, crystalline chemical compound first isolated from petroleum with a camphor-like odor. Adamantane is used to treat influenza A virus infections.
|
| E0649 |
ADAMTS-5 Inhibitor |
ADAMTS-5 Inhibitor is a potent ADAMTS-5 (aggrecanase-2) inhibitor, with an IC50 of 1.1 µM. |
| S1276 |
Adapalene |
Adapalene (CD-271) is a dual RAR and RXR agonist, used in the treatment of acne. |
| E1661 |
Adaptaquin |
Adaptaquin is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PHD2), with an IC50 of 2 μM. Adaptaquin also inhibits lipid peroxidation and maintains mitochondrial function. |
| S8501 |
Adaptavir (DAPTA) |
Adaptavir (DAPTA, D-Ala-peptide T-amide, peptide T) is a water soluble potent, selective CCR5 antagonist which potently inhibits specific CD4-dependent binding of gp120 Bal (IC50 = 0.06 nM) and CM235 (IC50 = 0.32 nM) to CCR5. |
| F1321 |
ADAR1 Rabbit mAb |
|
| E0466 |
Adarotene |
Adarotene (ST1926) causes a dose-dependent growth inhibition in a large panel of human tumor cell lines with IC50 ranging from 0.1 to 0.3 µM, causes cell accumulation in G1/S or S phase of cell cycle depending on tumor cells, exhibiting a potent antiproliferative activity. |
| S8761 |
Adavivint (SM04690) |
Adavivint (SM04690,Lorecivivint) is a potent and specific inhibitor of canonical Wnt signaling with an EC50 of 19.5 nM for inhibiting the TCF/LEF reporter. It is ∼150- to 500-fold more potent than the other known Wnt inhibitors across multiple cellular assays. |
| S1525 |
Adavosertib (MK-1775) |
Adavosertib (MK-1775, AZD1775) is a potent and selective Wee1 inhibitor with IC50 of 5.2 nM in a cell-free assay; hinders G2 DNA damage checkpoint. Phase 2. |
| F3599 |
ADCY9 / AC9 Rabbit mAb |
|
| S5068 |
Adefovir |
Adefovir is an orally administered nucleotide analog reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection. |
| S1718 |
Adefovir Dipivoxil (GS 0840) |
Adefovir Dipivoxil (GS 0840) is a reverse transcriptase inhibitor, used in the treatment of chronic hepatitis B virus (HBV). |
| S6551 |
Adelmidrol |
Adelmidrol is an analogue of palmitoylethanolamide (PEA) with anti-inflammatory activities. |
| S5109 |
Ademetionine |
Ademetionine (AdoMet, S-Adenosylmethionine, SAMe), also known as SAMe, is a specific form of the amino acid methionine known as S-adenosyl-methionine. It is essential for the formation of glutathione, a water-soluble peptide that helps the body fight free radicals. |
| S4515 |
Ademetionine disulfate tosylate |
Ademetionine Disulfate Tosylate is the disulfate-tosylate mixed salt of a mixture of diastereoisomers of the ademetionine ions. Ademetionine possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. |
| S1981 |
Adenine |
Adenine(6-Aminopurine) is a purine derivative and a nucleobase with a variety of roles in biochemistry.Adenine can be used to induce animal models of Tubulointerstitial Fibrosis. |
| S1983 |
Adenine HCl |
Adenine HCl(6-Aminopurine hydrochloride) is a hydrochloride salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry.Adenine HCl can be used to induce animal models of Tubulointerstitial Fibrosis. |
| S1982 |
Adenine sulfate |
Adenine sulfate(Adenine hemisulfate) is a sulfate salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry.Adenine sulfate can be used to induce animal models of Tubulointerstitial Fibrosis. |
| E3604 |
Adenophora Stricta Extract |
Adenophora Stricta Extract is extracted from Adenophora stricta Miq.. Adenophora stricta is commonly used to reduce phlegm, clear lung and tonify stomach. |
| S1647 |
Adenosine |
Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a β-N9-glycosidic bond. |
| S5284 |
Adenosine 5'-monophosphate monohydrate |
Adenosine 5'-monophosphate monohydrate (5'-Adenylic acid, 5'-AMP) is an activator of a class of protein kinases known as AMP-activated protein kinase (AMPK). |
| S6325 |
Adenosine 5′-diphosphate sodium salt |
Adenosine 5′-diphosphate (ADP, Adenosine diphosphate, Adenosine 5′-pyrophosphate, Adenosine pyrophosphate) is an important organic compound in metabolism and is essential to the flow of energy in living cells. ADP can be interconverted to adenosine triphosphate (ATP) and adenosine monophosphate (AMP). |
| E7737 |
Adenosine 5′-diphosphoribose sodium |
Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD+) metabolite. Adenosine 5′-diphosphoribose sodium is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose sodium also can enhance autophagy. |
| S9370 |
Adenosine Cyclophosphate |
Adenosine Cyclophosphate (Cyclic adenosine monophosphate, cAMP, cyclic AMP, 3',5'-cyclic adenosine monophosphate) is useful for improving myocardial hypoxia, dilating coronary artery and strengthening myocardiac contraction. |
| S9367 |
Adenosine disodium triphosphate hydrate |
Adenosine disodium triphosphate hydrate(ATP disodium) is the sodium salt form of adenosine triphosphate (ATP), a complex organic chemical that provides energy to drive many processes in living cells., , |
| S1076 |
Adezmapimod (SB203580) |
Adezmapimod (SB203580, RWJ 64809, PB 203580) is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM in THP-1 cells, 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and blocks PKB phosphorylation with IC50 of 3-5 μM. SB203580 induces mitophagy and autophagy. |
| E4791 |
Adezmapimod hydrochloride |
Adezmapimod hydrochloride (RWJ 64809 hydrochloride, SB 203580 hydrochloride) is an inhibitor of the MAPK family member termed as stress-activated protein kinase 2a(SAPK2a; also known as p38). It exhibits IC50 of SAPK2a/p38 and SAPK2b/p38β2 with IC50 values of 50 nM and 500 nM respectively and can be used in research of chronic inflammatory diseases, such as rheumatoid arthritis. |
| P1239 |
ADH-1 |
ADH-1, an antagonist of N-cadherin, blocks N-cadherin-mediated cell adhesion. It exhibits significant antitumor activity against N-cadherin-expressing cells in vitro assays. |
| S0525 |
ADH-503 (GB1275) |
ADH-503 (GB1275, (Z)-Leukadherin-1 choline) is the salt form of leukadherin-1 and acts as a potent allosteric agonist of CD11b. |
| S2082 |
Adiphenine HCl |
Adiphenine HCl(NSC 129224) is a nicotinic receptor inhibitor, used as an antispasmodic drug. |
| S3594 |
Adipic acid |
Adipic acid (Hexanedioic acid) is an important dicarboxylic acid used for the manufacture of nylon and polyurethane plastics. |
| F3384 |
Adiponectin Rabbit mAb |
|
| S7365 |
AdipoRon |
AdipoRon (SC-396658) is a novel, and orally bioavailable adiponectin receptor agonist with KD of 1.8 and 3.1 μM for AdipoR1 and AdipoR2, respectively. |
| S0454 |
Adjudin |
Adjudin (AF-2364), a potent male contraceptive, is a potent blocker of Cl⁻ channels. Adjudin exhibits anti-inflammatory properties by suppression of NF-κB p65 nuclear translocation and DNA binding activity as well as ERK MAPK phosphorylation. |
| S0555 |
Adomeglivant |
Adomeglivant (LY2409021) is a potent and selective antagonist of glucagon receptor that is used as a chronic treatment for type 2 diabetes. |
| A5415 |
ADORA1 Rabbit Recombinant mAb |
ADORA1 Rabbit Recombinant mAb detects endogenous level of total ADORA1. |
| S8608 |
ADOX (Adenosine Dialdehyde) |
ADOX (Adenosine Dialdehyde) is an adenosine analog and S-adenosylmethionine-dependent methyltransferase inhibitor with an IC50 of 40 nM. |
| S9368 |
ADP |
ADP (Adenosine diphosphate, adenosine pyrophosphate, Adenosine 5'-diphosphate) is an important organic compound in metabolism and is essential to the flow of energy in living cells. |
| S5224 |
Adrafinil |
Adrafinil (benzhydrylsulfinylacetohydroxamic acid, adrafinyl, CRL-40028) is a mild central nervous system stimulant drug directly affecting CNS function. It is used to relieve excessive sleepiness and inattention in elderly patients. |
| S3185 |
Adrenalone HCl |
Adrenalone is an adrenergic agonist used as a topical vasoconstrictor and hemostatic, mainly acts on alpha-1 adrenergic receptors. |
| F2415 |
Adrenergic α 1A Receptor/ADRA1A Rabbit mAb |
|
| E1969 |
ADT-007 |
ADT-007 is a potent and orally active pan-RAS inhibitor. ADT-007 effectively targets and suppresses the proliferation of cancer cells harboring mutated or hyper-activated wild-type RAS isozymes. ADT-007 exhibits potent anti-cancer effects. |
| S3192 |
ADX-102 |
Reproxalap (ADX-102, NS-2) is a potent topically administered inhibitor of reactive aldehyde species (RASP).It exhibits anti-inflammatory and pain-relieving effects by covalently binding aldehydes, reducing eye inflammation, and showing clinical efficacy in dry eye disease, allergic conjunctivitis, and noninfectious anterior uveitis. |
| S2690 |
ADX-47273 |
ADX47273 (BA 94673139) is a potent and specific mGlu5 positive allosteric modulator(PAM) with EC50 of 0.17 μM, showing no activity at other mGlu subtypes. |
| F0929 |
AEBP2 Rabbit mAb |
|
| S1486 |
AEE788 (NVP-AEE788) |
AEE788 (NVP-AEE788) is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM, less potent to VEGFR2/KDR, c-Abl, c-Src, and Flt-1, does not inhibit Ins-R, IGF-1R, PKCα and CDK1. Phase 1/2. |
| E3680 |
Aesculus chinensis Bunge fruits Extract |
Aesculus chinensis Bunge fruits Extract is extracted from the fruits of Aesculus chinensis Bunge, which can suppress the metastasis of triple-negative breast cancer by inhibiting epithelial-mesenchymal transition via down-regulating LOXL2 expression. |
| S0405 |
AF-353 |
AF-353 (Ro-4) is a potent, selective and orally bioavailable antagonist of P2X3 receptor and P2X2/3 receptor with pIC50 of 8.06, 8.05 and 7.41 for human P2X3, rat P2X3 and human P2X2/3, respectively. |
| E7758 |
AF12198 |
AF12198 is a potent, selective and specific peptide antagonist for human type I interleukin-1 receptor (IL1-R1) (IC50=8 nM) but not the human type II receptor (IC50=6.7 µM) or the murine type I receptor (IC50>200 µM). AF12198 inhibits IL-1-induced IL-8 production (IC50=25 nM) and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression (IC50=9 nM) in vitro. AF12198 has anti-inflammatory activities and blocks responses to IL-1 in vivo. |
| S7478 |
AF38469 |
AF38469 is a selective, orally bioavailable Sortilin inhibitor with an IC50 value of 330 nM. |
| H2994 |
AF488 Anti-BCRP1 (5D3) mAb |
Breast cancer resistance protein (BCRP1), also known as placenta-specific ATP-binding cassette (ABC) protein (ABCP) or ABC G-subfamily member 2 (ABCG2), or mitoxantrone resistance protein (MXR), is a member of the ATP-binding cassette superfamily of drug transporters thought to be involved in multi-drug resistance in human neoplastic disease. ABCG2 is expressed in drug-resistant breast, colon and gastric cancer and fibrosarcoma cancer cell lines and in blast cells from patients with acute myeloid leukemia (AML). Normal tissues that express the ABCG2 protein include placental syncytiothrophoblasts, mammary ducts and lobules, epithelium in the large intestine and colon, venous and capillary epithelium and bile canalicular membrane of the live |
| G3459 |
AF488 Anti-CD105/Endoglin (MJ7/18) mAb |
CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up-regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation-associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2. |
| G0264 |
AF488 Anti-CD105/Endoglin (SN6) mAb |
CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2. |
| G4059 |
AF488 Anti-CD117/c-Kit (2B8) mAb |
KIT (c-KIT), also known as CD117, is a proto-oncogene and a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). KIT was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT together with its ligand regulates growth and activation of a variety of hemopoietic and non-hemopoietic cells. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Recently, deregulation of the KIT receptor TK by the prevalent activation loop mutation D816V has served as a focal point in therapeutic strategies aimed at curbing neoplastic mast cell growth. c-Kit is expressed in hematopoietic stem cells, germ cell |
| G0099 |
AF488 Anti-CD11c (N418) mAb |
CD11, along with CD18, form a heterodimer adhesion molecule. In particular, CD11 is composed of CD11a, CD11b and CD11c. CD11a is a leukocyte marker that is expressed in B and T lymphocytes, macrophages, monocytes, neutrophils, basophils and eosinophils. CD11b is primarily expressed by monocytes, macrophages, natural killer cells, some B and T-cells, and granulocytes. CD11c is expressed in monocytes, macrophages, natural killer cells, some granulocytes and less so in a subset of lymphocytes. |
| G0459 |
AF488 Anti-CD127 (A7R34) mAb |
CD127, also known as the Interleukin-7 receptor alpha chain (IL-7Ralpha), is a type I glycoprotein with a molecular weight of 75-80 kDa. It forms a multi-functional receptor complex with CD132, the common gamma chain, to create the IL-7 receptor (IL-7R), which is crucial for lymphopoiesis. The active IL-7 receptor is an alpha/gamma chain heterodimer, where the gamma chain also associates with the interleukin-2 receptor and primarily activates signal transduction, while the alpha chain determines specific signaling events through its association with cytoplasmic signaling molecules. CD127 is expressed by immature B cells through the early pre-B stage, thymocytes during various stages of development, and most mature T cells, with transient do |
| H0339 |
AF488 Anti-CD161 (HP-3G10) mAb |
CD161, also known as NKR-P1A, is a type II transmembrane lectin-like receptor and member of the killer cell lectin-like receptor (KLR) family. CD161 exists as a homodimer and is prominently expressed on natural killer (NK) and NKT cells, where it is proposed to regulate the function of both cell types. CD161 is also found on T cell subsets, including T regulatory cells (Tregs), memory/effector CD4+ T cells, and CD8+ T cells. Th17 cells have been demonstrated to co-express CD161, as surface IL-17A+ cells are contained within the CD161+ fraction of CD4 T cells, so that CD161 (in combination with CCR6) is often used as a marker for enrichment of Th17 cells. |
| G0609 |
AF488 Anti-CD184/CXCR4 (2B11) mAb |
CXCR4 (Fusin, LESTR, HUMSTR) is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains, and functions as a co-receptor for X4 HIV-1 entry into CD4+ cells. CXCR4 has been proved to be the co-receptor for HIV-2's binding to CD4 through envelope glycoprotein gp 120 and promotes Env-mediated fusion of the virus. In other cases, CXCR4 can even function as the only receptor for HIV-2's binding to the CD4 host cells. CXCR4 is the receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. CXCR4 acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced c |
| G1719 |
AF488 Anti-CD1d (1B1) mAb |
CD1d is a heavy chain associated with Beta 2 microglobulin on cortical thymocytes. Beta 2 microglobulin independent expression of CD1d has also been demonstrated on human intestinal epithelial cells. CD1d is the sole group 2 member of the CD1 family of major histocompatibility (MHC) like glycoproteins. The CD1d gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 |
| G4134 |
AF488 Anti-CD23 (B3B4) mAb |
CD23 is a 45 kDa glycoprotein that serves as a low-affinity receptor for IgE, playing a crucial role in regulating IgE responses and B cell activation. It is expressed on mature B cells, mantle zone B cells, follicular dendritic cells, and at lower levels on T cells, NK cells, Langerhans cells, and platelets. CD23 expression is upregulated upon B cell activation, and its soluble forms are biologically active, acting as potent mitogenic factors. CD23 is strongly expressed on Epstein-Barr virus (EBV)-transformed B lymphoblasts and is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells. It is also detected in neoplastic cells from cases of B cell chronic lymphocytic leukemia and some centroblastic/centrocytic lym |
| G0279 |
AF488 Anti-CD24 (M1/69) mAb |
CD24 is a 35-50 kDa glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed on a variety of cell types, including erythrocytes, thymocytes, peripheral lymphocytes, and cells of the myeloid lineage. It is variably glycosylated, resulting in heterogeneity in molecular mass across different cell lineages, which can affect antibody staining levels on lymphocyte populations. In the context of B-cell development, CD24 is expressed from the pro-B-cell stage in the bone marrow through to mature, surface Ig-positive B cells, with very low or negative expression on plasma cells. It is also present on the majority of B-lineage acute lymphoblastic leukemias, B-cell chronic lymphocytic leukemias (CCLs), and B-cell non-Hodgkin's lymphomas. CD2 |
| G1104 |
AF488 Anti-CD278 (C398.4A) mAb |
ICOS, also known as inducible costimulatory molecule and H4, is a 47-57 kD protein. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes. It is able to costimulate T cells proliferation. In addition, ICOS is involved in humoral immune responses (B cell germinal center formation). The ICOS ligand is B7h/B7RP-1 or B7-H2. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development. |
| H0699 |
AF488 Anti-CD284/TLR4 (HTA125) mAb |
TLR4 is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This receptor is most abundantly expressed in placenta, and in the myelomonocytic subpopulation of leukocytes. Mammalian cells respond to LPS by activating TLR4. TLR4 belongs to the multi-protein complex of the lipopolysaccharide (LPS) receptor, containing CD14, LY96, and TLR4, and is involved in signal transduction events induced by LPS found in most gram-negative bacteria. TLR4 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents and |
| G4104 |
AF488 Anti-CD326/EpCAM (G8.8) mAb |
Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA), also known as CD326, is a transmembrane glycoprotein expressed in the epithelium with a molecular weight of approximately 40 kDa, which functions as an epithelial cell adhesion molecule. Ep-CAM functions as a homotypic calcium-independent cell adhesion molecule, and has a direct impact on cell cycle, proliferation and metabolism of epithelial cells and fibroblasts due to its ability to rapidly induce the proto-oncogene c-myc and the cell cycle regulating genes cyclin A and E. Ep-CAM mediates Ca2+-independent homotypic interactions. Formation of Ep-CAM-mediated adhesions have a negative regulatory effect on adhesions mediated by classic cadherins, which may have strong |
| G0084 |
AF488 Anti-CD44 (IM7) mAb |
CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential. CD44 is expressed by hematopoietic, non-hematopoietic cells, epithelial tissu |
| G0024 |
AF488 Anti-CD45 (30-F11) mAb |
CD45, also known as Leukocyte Common Antigen (LCA). CD45 is expressed by all hematopoietic cells excluding mature erythrocytes and platelets. The cytoplasmic portion of CD45 has tyrosine phosphatase enzymatic activity and plays an important role in activation of lymphocytes.
|
| G0354 |
AF488 Anti-CD45.1 (A20) mAb |
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides t |
| G0114 |
AF488 Anti-CD45R/B220 (RA3-6B2) mAb |
CD45R (PTPRC) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. CD45 contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. CD45 is specifically expressed in hematopoietic cells and has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists in multiple isoforms as a result of alternative splicing, and these isoforms di |
| G3489 |
AF488 Anti-CD5 (53-7.3) mAb |
CD5 is a 67 kDa human T-lymphocyte single-chain transmembrane glycoprotein. CD5 is present on all mature T-lymphocytes, on most of thymocytes and on many T-cell leukemias and lymphomas. CD5 also reacts with a subpopulation of activated B-cells and may act as a receptor in regulating T-cell proliferation. CD5 is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. CD5 is expressed by many T cell leukemia, lymphomas, and activated T cells. Diseases associated with CD5 dysfunction include thymus cancer and Richter's Syndrome. |
| G0249 |
AF488 Anti-CD62L/L-Selectin (MEL-14) mAb |
The human CD62L is a 74-95 kDa glycoprotein member of the selectin family of adhesion receptors. L-Selectin is comprised of an aminoterminal C-type lectin binding domain, an epidermal growth factor-like domain, two short consensus repeat (SCR) sequences homologous to those found in complement binding proteins, a short spacer region, a transmembrane region and a short cytoplasmic region. Human CD62L (L-Selectin) is constitutively expressed on all classes of leukocytes including lymphocytes (except a substantial population of memory T cells), monocytes and polymorphonuclear cells. |
| G0489 |
AF488 Anti-CD68 (ED1) mAb |
CD68 antibody recognizes the rat ED1 antigen, a heavily glycosylated protein of ~90 -110 kDa, also known as rat CD68. The ED1 antigen is expressed on most macrophages populations, as well as on monocytes and is considered as a pan-macrophage marker in the rat. ED1 is expressed predominantly on the lysosomal membrane and lightly on the cell surface. The expression of ED1 antigen being predominantly cytoplasmic, flow cytometry results are improved by the use of a membrane permeabilization procedure, such as Leucoperm, prior to staining. |
| G0504 |
AF488 Anti-CD68 (FA-11) mAb |
CD68 is considered a pan-macrophage marker, predominantly expressed on the intracellular lysosomes of tissue macrophages/monocytes, including Kupffer cells, microglia, histiocytes and osteoclasts, and is expressed to a lesser extent by dendritic cells and peripheral blood granulocytes. CD68 is expressed by many tumor types including some B cell lymphomas, blastic NK lymphomas, melanomas, granulocytic (myeloid) sarcomas, hairy cell leukemias, and renal, urinary and pancreatic tumors, and can be used to demonstrate the presence/localization of macrophages. |
| G0219 |
AF488 Anti-CD80/B7-1 (16-10A1) mAb |
CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28, and of an inhibitory receptor CTLA-4 (CD152). Both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, and both molecules can also substitute for each other in this process. CD80 is rapidly induced on the surface of in vitro activated B cells, with Epstein Barr Virus (EBV) transformed B cell lines, with Burkitts lymphoma cell lines, with freshly isolated follicular B lymphoma cells, T cells, and monocytes. The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 and CTLA4 ligands of T cells. Diseases associated with CD80 dysfunct |
| G0009 |
AF488 Anti-CD8a (53-6.7) mAb |
CD8 (Cluster of differentiation 8), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, plays an integral role in signal transduction, and T cell differentiation and activation. CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8alpha and CD8beta, where it functions as a co-receptor, along with T cell receptor (TCR), for major histocompatibilty complex class I (MHC-I) molecules; whereas its counterpart, CD4, acts as a co-receptor for MHC-II molecules. CD8 exists on the cell surface, where the CD8alpha chain is essential for binding to MHC-I. CD8 is also expressed on a subset of T cells, NK cells, monocytes and dendritic cells as disulfide-linked homodimers of CD8alpha. Ligation of MH |
| G2184 |
AF488 Anti-DYKDDDDK Tag (L5) mAb |
The DYKDDDDK tag is often used as a protein modification in order to simplify the labeling and detection of proteins.This unique amino acid sequence allows for specific antibody detection in western blotting, immunoprecipitation, and immunostaining techniques.Due to the short sequence, this modification is not likely to affect the structure or function of the modified proteins. |
| H0774 |
AF488 Anti-FCER1A (AER-37 (CRA1)) mAb |
Fc epsilon RI alpha, also known as FcεRIα, is a subunit of the high-affinity receptor for IgE, primarily expressed on mast cells and basophils. Its expression is upregulated by the presence of IgE. FcεRIα forms a tetrameric complex with one beta and two gamma subunits, which are essential for signal transduction. The beta and gamma subunits contain immunoreceptor tyrosine-based activation motifs (ITAMs). The FcεRI complex plays a crucial role in triggering IgE-mediated allergic reactions.
When allergen-bound IgE molecules bring together two or more high-affinity IgE receptors, it leads to the release of mediators such as histamine, which are responsible for allergy symptoms.
This process couples allergens and mast cells to initiate inflamma |
| G0039 |
AF488 Anti-FOXP3 (FJK-16s) mAb |
FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-alle |
| G3744 |
AF488 Anti-HER2/ErbB2 (H24A7) mAb |
The ErbB2 (HER2) proto-oncogene encodes a 185 kDa transmembrane, receptor-like glycoprotein with intrinsic tyrosine kinase activity. While ErbB2 lacks an identified ligand, ErbB2 kinase activity can be activated in the absence of a ligand when overexpressed and through heteromeric associations with other ErbB family members. Amplification of the ErbB2 gene and overexpression of its product are detected in almost 40% of human breast cancers. Binding of the c-Cbl ubiquitin ligase to ErbB2 at Tyr1112 leads to ErbB2 poly-ubiquitination and enhances degradation of this kinase. ErbB2 is a key therapeutic target in the treatment of breast cancer and other carcinomas and targeting the regulation of ErbB2 degradation by the c-Cbl-regulated proteolyt |
| H0459 |
AF488 Anti-Human CD107a (H4A3) mAb |
CD107a, also known as Lysosomal-associated membrane protein 1 (LAMP-1), is a ~110 kDa type I transmembrane protein that is heavily glycosylated and widely expressed by cells primarily on the luminal surface of their lysosomes. It is also expressed on the surface of activated platelets, activated lymphocytes, cytotoxic T cells and NK cells, and some tumor cell lines, including U937 and KG1a. LAMP-1 can serve as a ligand for E-selectin-mediated cell adhesion. LAMP-1 and LAMP-2 (CD107b) are carriers for poly-N-acetyllactosamines and are able to display sialyl Le[x] termini. |
| H0384 |
AF488 Anti-Human CD117 (104D2) mAb |
CD117 is a 145 kD protein tyrosine kinase also known as c-Kit. It is a receptor for stem cell factor or c-Kit ligand. CD117 is expressed on pluripotent hematopoietic progenitor cells (approximately 1-4% bone marrow cells), mast cells, and acute myeloid leukemia cells (AML). CD117 binding of c-Kit ligand induces phosphorylation of CD117 and stimulates proliferation and survival of primitive hematopoietic stem cells as well as erythroid-committed and granulo-monocytic committed cells. |
| H3324 |
AF488 Anti-Human CD11a (HI111) mAb |
This antibody specifically binds to CD11a, the 180 kDa integrin α chain. This type I transmembrane glycoprotein associates with CD18 (integrin β2) to form the heterodimeric glycoprotein CD11a/CD18. This heterodimer is also known as the lymphocyte (leukocytes) function associated antigen-1 (LFA-1) that is expressed on all leukocytes. LFA-1 is an adhesion molecule involved in lymphocyte and granulocyte functions. LFA-1 mediates adhesion of lymphoid cells to the vascular endothelium in association with its ligand, and the intracellular adhesion molecule-1 (ICAM-1), CD54. Other ligands are ICAM-2 (CD102) and ICAM-3 (CD50). Purified Mouse Anti-Human CD11a antibody also cross reacts with all leukocytes of baboon, and both rhesus and cynomolgus ma |
| H0069 |
AF488 Anti-Human CD11b (ICRF44) mAb |
CD11b is a 165-170 kD type I transmembrane glycoprotein also known as αM integrin, Mac-1, CR3, and C3biR. CD11b non-covalently associates with integrin β2 (CD18) and is expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b/CD18 is critical for the transendothelial migration of monocytes and neutrophils. It is also involved in granulocyte adhesion, phagocytosis, and neutrophil activation. CD11b/CD18 interacts with ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4, CD14, CD23, heparin, iC3b, fibrinogen, and factor X. |
| H0144 |
AF488 Anti-Human CD11c (3.9) mAb |
CD11c is a 145–150 kDa type I transmembrane glycoprotein also known as integrin αx and CR4. CD11c non-covalently associates with integrin β2 (CD18) and is expressed on monocytes/macrophages, dendritic cells, granulocytes, NK cells, and subsets of T and B cells. CD11c has been reported to play a role in adhesion and CTL killing through its interactions with fibrinogen, CD54, and iC3b. |
| H0189 |
AF488 Anti-Human CD14 (M5E2) mAb |
CD14 is a 53–55 kDa glycosylphosphatidylinositol (GPI)-anchored single-chain glycoprotein expressed at high levels on monocytes, macrophages, and neutrophils. CD14 is a multifunctional receptor and is constitutively expressed on the surface of mature monocytes and macrophages. It serves as a high-affinity receptor for lipopolysaccharide (LPS) and binds LPS in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute-phase serum protein. CD14 also exists in a soluble form (sCD14) and is released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. The soluble sCD14 is important for neutralizing allochthonous lipopolysaccharides by reconstituted lipoprotein particles and can discriminate structural dif |
| H1044 |
AF488 Anti-Human CD146 (P1H12) mAb |
CD146, also known as MCAM, MUC18, or Mel-CAM, is a 118 kDa transmembrane glycoprotein and a member of the immunoglobulin superfamily. It is strongly expressed by blood vessel endothelium and smooth muscle. CD146 is also found on angioblasts, mesenchymal stem cells, melanoma cells, intermediate trophoblasts, and a subset of activated T cells. CD146 is widely used as a marker for endothelial cells and plays a key role in studies of angiogenesis, cancer progression, and vascular biology. |
| H1134 |
AF488 Anti-Human CD16 (3G8) mAb |
CD16a is a ~50–65 kDa type I transmembrane glycoprotein encoded by FCGR3A (Fc fragment of IgG receptor IIIa), which belongs to the immunoglobulin superfamily. CD16a is also known as Fc-gamma RIII-alpha (FcγRIIIA or FcRIIIa) and is expressed on natural killer (NK) cells, activated monocytes, macrophages, γδ T cells, immature thymocytes, and mast cells. CD16a binds immune-complexed or aggregated IgG and associates with CD247/TCRζ in NK cells and FcεRIγ chains in phagocytes and mast cells to transduce intracellular signals. CD16a functions in antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses including phagocytosis, cytokine production, or mediator release. CD16b is a ~48 kDa glycophosphatidylinositol (GPI)- |
| H3504 |
AF488 Anti-Human CD163 (GHI/61) mAb |
CD163 is also known as Scavenger receptor cysteine-rich type 1 protein M130 (M130), Hemoglobin scavenger receptor and Macrophage-associated antigen. CD163 is a 110-130 kDa transmembrane glycoprotein. CD163 is a monocyte/macrophage-restricted antigen expressed on the majority of tissue macrophages and peripheral blood monocytes. CD163 belongs to the scavenger receptor superfamily. Its expression on monocytes is upregulated upon cellular activation. CD163 expression reportedly changes on monocytes and macrophages as these cells differentiate. This finding suggests a role for this molecule in the differentiation and/or regulation of monocyte and macrophage function. CD163 may play a role in the clearance and endocytosis of hemoglobin and hapto |
| H2829 |
AF488 Anti-Human CD166/ALCAM (3A6) mAb |
CD166, also known as Activated Leukocyte Cell Adhesion Molecule (ALCAM) and the CD6 ligand, is a 100–105 kDa transmembrane glycoprotein belonging to the immunoglobulin superfamily. It consists of an immunoglobulin-like extracellular domain, a transmembrane region, and a short cytoplasmic tail. CD166 is expressed on neurons, activated T cells, activated monocytes, epithelial cells, and fibroblasts. It plays a key role in mediating adhesion interactions, particularly between thymic epithelial cells and CD6+ cells during intrathymic T-cell development. |
| H1239 |
AF488 Anti-Human CD185 (RF8B2) mAb |
CXCR5 (also known as CD185, BLR-1 NLR and MDR15), a seven transmembrane, G-protein-coupled receptor, is the specific receptor for CXC chemokine, CXCL13/BLC/BCA-1. In peripheral blood, CXCR5 expression is restricted to B lymphocytes and a small subset of CD4+ and CD8+ lymphocytes. The restricted expression pattern of CXCR5 on B cells and follicular T helper cells (Tfh) suggests that this receptor functions as a regulator of B and T cell migration. Stimulation of T cells with anti-CD3 monoclonal antibody leads to the down-regulation of CXCR5. |
| H0009 |
AF488 Anti-Human CD19 (HIB19) mAb |
CD19 is a 95 kDa type I transmembrane glycoprotein expressed during all stages of B-cell maturation and differentiation, except on plasma cells. It is also present on follicular dendritic cells but not found on T cells or normal granulocytes. CD19 functions as a signal transduction molecule that regulates B cell development, activation, proliferation, and differentiation. It associates with complement receptor 2 (CD21), TAPA-1 (CD81), Leu 13, and/or MHC class II to form a signal transduction complex on the surface of B cells.
|
| H0024 |
AF488 Anti-Human CD19 (LT19) mAb |
CD19 is a type I transmembrane glycoprotein of 95 kDa that belongs to the immunglobulin superfamily. CD19 is expressed on B cells throughout most stages of B cell differentiation, though its expression is down-regulated during their terminal differentiation to plasma cells. Expression of CD19 is also found in the majority of B cell–derived malignancies. CD19 is further present on follicular dendritic cells. On B cells, CD19 associates with CD21, CD81, and CD225 (Leu-13) forming a signal transduction complex. |
| H1584 |
AF488 Anti-Human CD1a (HI149) mAb |
CD1a is a type I transmembrane glycoprotein. The 49 kDa CD1a polypeptide is associated with β2-microglobulin. CD1a is expressed on cortical thymocytes, dendritic cells and Langerhans cells. CD1a has structural similarities to the MHC class I antigen, and plays a role in antigen presentation. |
| H1599 |
AF488 Anti-Human CD1c (L161) mAb |
CD1c, also known as R7 or M241, is a 43 kD member of the five CD1 antigens (CD1a-e) in humans. The CD1 molecules are type I glycoprotein with structural similarities to MHC class I and are non-covalently associated with β2-microglobulin, belonging to the Ig superfamily. CD1c is expressed on cortical thymocytes, Langerhans cells, dendritic cells, and a subset of B cells. It has been reported that CD1c is also expressed on mature T cells in a tightly regulated manner. CD1c is involved in antigen-presentation of glycolipids. It may also act in T cells as an immune regulatory molecule. |
| H1164 |
AF488 Anti-Human CD20 (2H7) mAb |
CD20 is a 33-37 kD, four transmembrane spanning protein, also known as B1 and Bp35. CD20 is expressed on pre-B-cells, resting and activated B cells (not plasma cells), some follicular dendritic cells, and at low levels on a T cell subset. CD20 is heavily phosphorylated on activated B cells and malignant B cells. Homo-oligomeric complexes of CD20 are thought to form Ca2+ conductive ion channels in the plasma membrane of B cells. The CD20 molecule is involved in B-cell activation and is associated with various Src family kinases (Lyn, Lck, Fyn). It exists in a complex with MHC class I and II, CD53, CD81, and CD82. |
| H0324 |
AF488 Anti-Human CD24 (ML5) mAb |
CD24, also known as CD24A, signal transducer CD24, small cell lung carcinoma cluster 4 antigen, or BA-1, is a 35-70 kDa glycophosphatidylinositol (GPI)-linked glycoprotein. Its glycosylation pattern is highly variable and cell-type dependent. CD24 is expressed on neutrophils, eosinophils, dendritic cells, neural cells, epithelial cells, muscle cells, and many types of cancer cells. CD24 functions as an adhesion receptor. Several different ligands have been identified for CD24, including CD62P (P-selectin), which is expressed on activated platelets and activated endothelium. CD24 is variably expressed on all B lineage cells, except plasma cells, and can play a role in regulating the activation, proliferation, or differentiation of these cell |
| H4119 |
AF488 Anti-Human CD271/NGFR (ME20.4) mAb |
CD271, also known as p75NTR, TNFRSF16, p75(NTR), Gp80-LNGFR, and NGFR, is a type I transmembrane protein with a MW of 75 kD. It is expressed by many cell types including neurons, Schwann cells, mesenchymal stem/stromal cells, follicular dendritic cells and melanocytes. The extracellular portion contains four TNFR-Cys repeats that form the binding domain for its ligands (NGF, BDNF, NTF3, and NTF4). The intracellular portion of CD271 contains a death domain, which interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9, to promote cell apoptosis, and to regulate cell differentiation and neurogenesis. |
| H0444 |
AF488 Anti-Human CD279/PD-1 (EH12.2H7) mAb |
Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC) are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion. |
| H4104 |
AF488 Anti-Human CD28 (CD28.2) mAb |
CD28 is a 44 kDa homodimeric transmembrane glycoprotein expressed on most mature T cells, thymocytes, and plasma cells. It acts as a costimulatory receptor, binding to CD80 and CD86 ligands, and plays a crucial role in T cell-B cell interactions. CD28 is believed to initiate and regulate a distinct signal transduction pathway that is separate from those stimulated by the TCR complex. The binding of CD28 to its ligands can also influence immune responses, including the production of IL-2 and changes in intracellular calcium concentrations. |
| H4284 |
AF488 Anti-Human CD3 (OKT-3) mAb |
CD3ε is one of five polypeptide chains that combine to form the TCR complex. CD3ε is expressed on T lymphocytes, NK-T cels, and to varying degrees on developing thymocytes. CD3 plays roles in TCR signaling, T lymphocyte activation, and antigen recognition. |
| H0234 |
AF488 Anti-Human CD31 (WM59) mAb |
CD31 (PECAM-1), also known as GPIIA' or EndoCAM, is a 130 kDa type I transmembrane glycoprotein belonging to the Ig gene superfamily. It is widely expressed on platelets, monocytes, granulocytes, NK cells, T cell subsets, and in high amounts on endothelial cells. CD31 functions as a vascular endothelial cell adhesion molecule, playing a critical role in the transendothelial migration of leukocytes during inflammatory responses. It is also involved in thrombosis, angiogenesis, and wound healing. The antibody against PECAM-1 binds to an epitope near extracellular domain 2 of CD31.
Clone WM59 also cross-reacts with peripheral blood platelets and leukocytes of baboon, and both rhesus and cynomolgus macaque monkeys. The staining intensity of WM5 |
| H0924 |
AF488 Anti-Human CD33 (WM53) mAb |
CD33, also known as Sialic acid-binding Ig-like lectin 3 (Siglec-3), gp67, or p67, is a 67 kDa type I transmembrane glycoprotein expressed on monocytes, activated T cells, myeloid progenitors, and mast cells. CD33 is absent on normal platelets, lymphocytes, erythrocytes, and hematopoietic stem cells. This glycoprotein can reportedly function as a sialic acid-dependent cell adhesion molecule. This function can be modulated by endogenous sialoglycoconjugates when CD33 is expressed on the membrane. |
| H0039 |
AF488 Anti-Human CD4 (RPA-T4) mAb |
CD4 is a 56 kDa transmembrane glycoprotein expressed on the T-helper/inducer subset of normal human peripheral blood lymphocytes. The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex |
| H0564 |
AF488 Anti-Human CD40 (5C3) mAb |
CD40 is a 45–48 kDa type I transmembrane glycoprotein primarily expressed on B lymphocytes, though it is absent on terminally differentiated B cells. It is also found on endothelial cells, basal epithelial cells, certain epithelial cell carcinomas, follicular dendritic cells, macrophages, fibroblasts, keratinocytes, and CD34+ hematopoietic progenitor cells. CD40 plays a critical role in B-cell growth, proliferation, and differentiation, including immunoglobulin isotype switching. Engagement of CD40, particularly in the presence of IL-4 or costimulation with anti-µ or anti-CD20 antibodies, can promote B-cell proliferation.
|
| H0894 |
AF488 Anti-Human CD41a (HIP8) mAb |
CD41a, also known as Integrin αIIb or Platelet GPIIb, forms a calcium-dependent complex with CD61 (β3 integrin or GPIIIa) that is normally expressed on platelets and megakaryocytes. The CD41/CD61 complex serves as a receptor for fibrinogen, fibronectin, and von Willebrand factor, mediating platelet adhesion and aggregation. Blocking CD41 can completely inhibit ADP-, epinephrine-, and collagen-induced platelet activation, and partially inhibit ristocetin- and thrombin-induced activation. |
| H0099 |
AF488 Anti-Human CD45 (HI30) mAb |
CD45 is encoded by the PTPRC (Protein tyrosine phosphatase receptor type C) gene. CD45, also known as the leukocyte common antigen (LCA), is a member of the protein tyrosine phosphatase (PTP) family. It is present on all human leukocytes including lymphocytes, monocytes, granulocytes, eosinophils, and thymocytes. CD45 is absent from circulating erythrocytes, platelets, or mature erythroid cells of bone marrow and non-hemopoietic tissues. |
| H0744 |
AF488 Anti-Human CD45RA (HI100) mAb |
CD45RA, a 220 kDa isoform of the human leukocyte common antigen, is expressed on approximately 40–50% of peripheral CD4+ T cells, 50% of peripheral CD8+ T cells, and on a portion of B cells and monocytes. The CD45RA antigen is expressed by naïve and activated T cells. CD45RA-specific antibodies are useful for the study of the suppressor/inducer subpopulation of CD4+ lymphocytes. |
| H4014 |
AF488 Anti-Human CD45RO (UCHL1) mAb |
CD45RO is a 180 kDa isoform of the CD45 molecule, also known as the Leukocyte Common Antigen. It is a type I transmembrane glycoprotein with cytoplasmic protein tyrosine phosphatase activity involved in signal transduction. Unlike other CD45 isoforms, CD45RO lacks the amino acid sequences encoded by the variable exons A, B, and C. It is expressed on most thymocytes, activated T cells, memory T cells, granulocytes, and monocytes, and on a subset of resting T cells. CD45RO and CD45RA mark largely distinct populations within resting peripheral T cells, demonstrating functional and phenotypic heterogeneity within CD4 and CD8 T cell subsets. CD45RO also interacts with CD22. |
| H0534 |
AF488 Anti-Human CD49f (GoH3) mAb |
CD49f, also known as the integrin α6 chain, is a ~150 kDa type I transmembrane glycoprotein that belongs to the integrin alpha chain family of extracellular matrix and cell adhesion receptors. The integrin α6 subunit associates with the integrin β1 chain (CD29) to form VLA-6, and with the integrin β4 chain (CD104) to form the integrin α6β4 complex, also known as the laminin and kalinin receptor. CD49f is expressed mainly on T cells, monocytes, platelets, epithelial cells, endothelial cells, perineural cells, and trophoblasts of the placenta. Antibodies against CD49f can block the binding of integrin α6 to laminin P1 and E8 fragments. |
| H0294 |
AF488 Anti-Human CD62L (DREG-56) mAb |
CD62L (L-selectin) is a cell surface glycoprotein expressed on neutrophils, monocytes, T- and B-lymphocyte subsets, and NK cells. CD62L functions as a lymphocyte homing receptor, playing a key role in the migration of lymphocytes to peripheral lymph nodes via high endothelial venules (HEV). |
| H1329 |
AF488 Anti-Human CD63 (H5C6) mAb |
CD63 is a 53 kDa, type III lysosomal glycoprotein that belongs to the tetraspan transmembrane 4 superfamily (TM4SF). It is expressed on activated platelets, monocytes, and macrophages, and is also known by several other names, including LIMP, gp55, melanoma-associated antigen ME491, Pltgp40, and LAMP-3. CD63 is widely expressed on the surface and in the cytoplasm of various hematopoietic cells (such as monocytes and macrophages) as well as non-hematopoietic cells (including endothelium, fibroblasts, osteoclasts, and smooth muscle cells). It plays a key role in mediating cellular adhesion and motility. |
| H0519 |
AF488 Anti-Human CD68 (Y1/82A) mAb |
CD68, also known as Scavenger receptor class D member 1 (SCARD1), Macrosialin, or GP110, is a 110 kDa type I transmembrane glycoprotein primarily localized in cytoplasmic granules of monocytes, macrophages, dendritic cells, granulocytes, myeloid progenitor cells, and reportedly, a subset of CD34-positive hematopoietic bone marrow progenitor cells. CD68 belongs to the sialomucin family and functions as a scavenger receptor, capable of binding and internalizing oxidized low-density lipoproteins (LDL). Antibodies targeting CD68 are commonly used in studies of myeloid cell development and function. |
| H0549 |
AF488 Anti-Human CD8 (SK1) mAb |
CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck. |
| H1479 |
AF488 Anti-Human CD83 (HB15e) mAb |
CD83 is a 45 kDa type I transmembrane glycoprotein that belongs to the immunoglobulin (Ig) superfamily. It is composed of a single V-type Ig extracellular domain and a C-terminal cytoplasmic tail. CD83 is primarily expressed on the surface of follicular dendritic cells, circulating dendritic cells, interdigitating dendritic cells in lymphoid tissues, in vitro-generated dendritic cells, and thymic dendritic cells. However, its expression is not limited to dendritic cells; it is also found on some germinal center B cells and certain lymphoblastoid cell lines. While the exact function of CD83 is not fully understood, it is believed to play a role in cell-cell interactions during antigen presentation. |
| H2079 |
AF488 Anti-Human Granzyme A (CB9) mAb |
Granzyme A is a 28 kD disulfide-linked homodimeric protein and the most abundant of the proteases occurring in CTL granules. It is homologous to other serine esterases, including other granyzmes, mast cell proteases, and neutrophil cathepsins. Granzyme B is thought to be a rapidly-acting apoptotic enzyme, while Granzyme A is slow acting. |
| H1794 |
AF488 Anti-Human HLA-A2 (BB7.2) mAb |
HLA-A2 is a class I molecule of the major histocompatibility complex (MHC) and part of the highly polymorphic group of cell-surface proteins encoded by the MHC gene locus. It plays a crucial role in the immune response by binding and presenting small antigenic protein fragments to antigen-specific receptors on T cells (TCR). Class I MHC molecules, like HLA-A2, bind peptides derived from intracellular antigens, such as viral and some bacterial antigens, which are recognized by CD8+ T cells. The TCRs recognize these processed peptides bound to the MHC, as well as regions of the MHC molecule itself, while CD4 and CD8 accessory molecules enhance the interaction by binding non-polymorphic regions of the MHC. |
| H3699 |
AF488 Anti-Human IgD (IA6-2) mAb |
IgD is a member of the immunoglobulin superfamily that exists in type 1-membrane (mIgD) and soluble glycoprotein forms. mIgD is expressed on mature naïve B cells (along with membrane IgM) and serves as a B-cell receptor for antigen (BCR). In response to antigen binding, the mIgD BCR, in association with other signaling molecules including CD79a and CD79b, can transduce activating or tolerizing signals intracellularly into B lymphocytes. |
| H1014 |
AF488 Anti-Human IgM (MHM-88) mAb |
IgM is the first immunoglobulin made by B cells in the immune response. Surface IgM is expressed on immature and mature B cells, while IgM heavy (μ) chain is expressed intracellularly in pre-B cells. |
| H1224 |
AF488 Anti-Human IL-2 (MQ1-17H12) mAb |
Interleukin-2 (IL-2) is a key cytokine involved in immune response and tolerance. It is produced by activated T cells and plays a crucial role in the activation, growth, proliferation, and differentiation of various immune cells, including T and B lymphocytes, LAK cells, NK cells, and monocytes/macrophages. IL-2 exerts its effects through binding to IL-2 receptor complexes, which include the intermediate-affinity IL-2R (comprising IL-2Rβ and γc) and the high-affinity IL-2R (which also includes IL-2Rα, along with IL-2Rβ and γc). IL-2 is essential for the proper functioning of the immune system, particularly in promoting T cell expansion and immune responses. |
| H0909 |
AF488 Anti-Human NKG2C/CD159c (134591) mAb |
Human NKG2C (also known as NK cell Group 2 isoform C, killer cell lectin like receptor subfamily C, member 2) is a member of the C type lectin like superfamily. NK receptors are expressed on both NK cells and cytotoxic CD8⁺ T cells and include both activating and inhibitory members. Regulation of the balance between activating and inhibitory receptors is important and its disruption has been implicated in autoimmunity. The NKG2 family includes NKG2A, -B, -C, -D, -E, -F, and -H; except for NKG2D and NKG2F, these receptors form heterodimers with CD94. NKG2C interacts with the adapter molecule DAP12 and operates as an activating receptor when paired with CD94. Human NKG2C is synthesized as a 231 amino acid protein, comprising a 70 aa cytoplasm |
| H1494 |
AF488 Anti-Human TCR α/β (IP26) mAb |
TCR α/β is a monomorphic determinant of the α/β T-cell receptor, which is expressed on over 95% of normal peripheral blood CD3+ T cells. The α/β T-cell receptor (TCR) plays a crucial role in recognizing peptides bound to MHC molecules, leading to T-cell activation. |
| H0129 |
AF488 Anti-IFN-lambda (4S.B3) mAb |
IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor and immune interferon that is produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemagglutinin, and other cytokines. IFN gamma is a dimeric protein consisting of two 146 amino acid subunits. IFN gamma is a glycoprotein that exists functionally as a homodimer of approximately 45 kDa. On SDS-PAGE, IFN gamma appears as a combination of 25, 20, and minor 15.5 kDa bands as a result of differential glycosylation. The biological activity of the IFN gamma homodimer is highly species specific. Human IFN gamma does not show cross-reactivity with mouse. IFN gamma exhibits functions such as a |
| G1914 |
AF488 Anti-IL-12/IL-23 p40 (C17.8) mAb |
IL-12 is a 70 kDa heterodimeric cytokine composed of two covalently linked chains, p40 and p35, and is secreted by activated monocytes, macrophages, and dendritic cells. IL-23 is a heterodimer composed of the disulfide-linked p19 protein and p40 protein, expressed by activated dendritic cells.IL-12 is an interleukin produced by dendritic cells, neutrophils, macrophages and human lymphoblastoid cells as a result of antigenic stimulation. IL-12 is a heterodimeric cytokine encoded by IL-12A (p35) and IL-12B (p40). IL-23 is a heterodimeric cytokine that shares a subunit with IL-12 (IL-12B) along with an IL-23A (IL-23p19) subunit. Functionally, IL-12 increases the expression of vascular endothelial adhesion molecule-1 on the endothelium, directs |
| G0324 |
AF488 Anti-Ki-67 (SolA15) mAb |
Ki-67 is a nuclear protein that is expressed during various stages in the cell cycle, particularly during late G1, S, G2, and M phases. The protein has a forkhead associated domain (FHA) through which it associates with euchromatin at the perichromosomal layer, the centromeric heterochromatin, and the nucleolus. Ki-67 is shown to have a cell cycle dependent topographical distribution with perinucleolar expression at G1, expression in the nuclear matrix at G2, and expression on the chromosomes during M phase. Ki-67 is commonly used as a proliferation marker because it is not detected in G0 cells, but increases steadily from G1 through mitosis. Ki-67 antibodies are useful in establishing the cell growing fraction in neoplasms. In neoplastic t |
| G0369 |
AF488 Anti-Ly-6A/E/Sca-1 (D7) mAb |
Stem Cell Antigen-1 (Sca-1) is a member of the lymphocyte antigen 6 (Ly-6) family. It is expressed on multipotent hematopoietic stem cells (HSC) and is used as a marker of HSC in mice. Sca-1 is used in combination with lineage depletion antibodies to identify murine HSC. Sca-1 can be found in fetal liver, adult bone marrow, and adult peripheral blood and spleen. Sca-1 may be involved in the regulation of B and T cell activation. |
| G1974 |
AF488 Anti-MERTK (DS5MMER) mAb |
MerTK is expressed on tissue macrophages and is involved in the removal of apoptotic cells. This process relies on two soluble ligands of MerTK, Protein S and Gas6 that bind to phosphatidylserine found on the outer leaflet of the plasma membrane of cells undergoing apoptosis. Upon binding these ligands, MerTK undergoes autophosphorylation at multiple tyrosine residues that activate the PI3K and Akt pathways. This results in the phagocytosis of apoptotic cells and also results in the direct inhibition of TLR-induced production of pro-inflammatory cytokines. In addition, MerTK may function as a putative entry receptor for filoviruses. Deficiency of MerTK causes general autoimmunity, inflammation and accumulation of apoptotic bodies. MerTK is |
| G0444 |
AF488 Anti-Mouse CD107a (1D4B) mAb |
CD107a, also known as Lysosome-Associated Membrane Protein 1 (LAMP-1), is a type I transmembrane glycoprotein that serves as a key marker of lysosomes. It is composed of a 40 kDa core protein that is heavily glycosylated, resulting in a mature glycoprotein ranging from 110 to 140 kDa. CD107a is predominantly expressed in epithelial cells and macrophages across various organs. Upon cellular activation, it translocates to the cell surface of lymphocytes, macrophages, epithelial cells, endothelial cells, platelets, and tumor cells. Surface expression of CD107a is involved in intercellular and extracellular matrix adhesion and is widely used as a functional marker of cytotoxic activity in NK cells and CD8+ T cells, as well as in identifying som |
| G0984 |
AF488 Anti-Mouse CD146 (ME-9F1) mAb |
CD146, also known as melanoma cell adhesion molecule (MCAM or Mel-CAM), MUC18, S-Endo1, and A32 antigen, is an integral membrane glycoprotein that belongs to the Ig superfamily. CD146 is strongly expressed by murine vascular endothelial cells. It is expressed on about 30% of neutrophils and 60% of NK cells. Unlike in humans, CD146 is undetectable on monocytes, dendritic cells, T cells, NKT cells, B cells, or smooth muscle cells in mouse. It has been reported that an increase in CD146 expression is associated with NK cell maturation. Combined with using CD27 and CD11b staining, CD146 may be an alternative marker to detect final stages of NK cell maturation and define NK cell subsets. CD146+ NK cells were found to be less cytotoxic and to pro |
| G1554 |
AF488 Anti-Mouse CD205/DEC-205 (NLDC-145) mAb |
CD205, also known as DEC-205, is a 205 kD integral membrane protein homologous to the macrophage mannose receptor. It is a type I cell surface protein that belong to the C-type lectin family. CD205 is expressed at high levels by dendritic cells and thymic epithelial cells. It is also expressed by a number of other cell types, such as B lymphocytes, macrophages, Langerhans cells, bone marrow stromal cells, granulocytes, epithelial cells of pulmonary airways, and the capillaries of the brain. CD205 is a novel endocytic receptor used by dendritic cells and thymic epithelial cells to direct captured antigens from the extracellular space to specialized antigen processing. It mediates antigen uptake and presentation and cross-presentation to |
| G4074 |
AF488 Anti-Mouse CD206/MMR (C068C2) mAb |
CD206, also known as mannose receptor (MR), is a 175 kD type I membrane protein. It is a pattern recognition receptor (PRR) belonging to the C-type lectin superfamily. MR is expressed on macrophages, dendritic cells, Langerhans cells, and hepatic or lymphatic endothelial cells. MR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine through its C-type lectin-like carbohydrate recognition domains, sulfated carbohydrate antigens through its cysteine-rich domain, and collagens through its fibronectin type II domain. MR mediates endocytosis and phagocytosis as well as activation of macrophages and antigen presentation. It plays an important role in host defense and provides a link between innate and ada |
| G4209 |
AF488 Anti-Mouse CD25/IL-2Rα (PC61.5) mAb |
Interleukin-2 receptor alpha (IL-2Rα), also known as CD25, Ly-43, p55, or Tac, is the 55 kDa ligand-binding subunit of the interleukin-2 receptor. IL-2Rα is expressed on activated mature T and B lymphocytes, thymocyte subsets, pre-B cells, and T regulatory cells. IL-2Rα plays roles in lymphocyte differentiation, activation, and proliferation. Alone, IL-2Rα binds IL-2 with relatively low affinity; however, when IL-2Rα associates with IL-2Rβ (CD122) and the common gamma chain (CD132), the complex binds IL-2 with high affinity. |
| G4644 |
AF488 Anti-Mouse CD3 (17A2) mAb |
CD3ε is one of five polypeptide chains that combine to form the TCR complex. CD3ε is expressed on T lymphocytes, NK-T cels, and to varying degrees on developing thymocytes. CD3 plays roles in TCR signaling, T lymphocyte activation, and antigen recognition. |
| G1254 |
AF488 Anti-Mouse CD357/GITR (DTA-1) mAb |
CD357, also known as GITR (Glucocorticoid-induced Tumor Necrosis Factor Receptor family-Related), is a 66-70 kDa homodimer glycoprotein that belongs to the TNF receptor superfamily. It is also referred to as TNFRSF18. GITR expression was first identified in T lymphocytes treated with dexamethasone, a glucocorticoid. In normal naive mice, GITR is expressed at moderate levels on CD25-positive/CD4-positive/CD8a-negative thymocytes and on CD25-positive/CD4-positive/CD45RB-low splenocytes. It is also expressed at low levels on splenic CD25-negative/CD4-positive/CD45RB-low T lymphocytes, B lymphocytes, macrophages, and dendritic cells. GITR expression is upregulated upon activation of T and B lymphocytes. As a costimulatory receptor, GITR plays a |
| G0849 |
AF488 Anti-Mouse CD38 (90) mAb |
CD38 is a 45 kD type II transmembrane glycoprotein also known as T10. It is an ADP-ribosyl hydrolase expressed at variable levels on hematopoietic cells and in some non-hematopoietic tissues (such as brain, muscle, and kidney). In humans, it is expressed at high levels on plasma cells and activated T and B cells, natural killer (NK) lymphocytes, myeloblasts, and erythroblasts. By functioning as both a cyclase and a hydrolase, CD38 mediates lymphocyte activation, adhesion, and the metabolism of cADPR and NAADP. CD31 is the ligand of CD38. |
| G4164 |
AF488 Anti-Mouse CD3epsilon (145-2C11) mAb |
CD3epsilon is a 20 kDa transmembrane cell-surface protein that belongs to the immunoglobulin superfamily. It is one of five polypeptide chains that combine to form the T cell receptor (TCR) complex. CD3ε is expressed on T lymphocytes, NK-T cells, and to varying degrees on developing thymocytes. CD3 plays critical roles in TCR signaling, T lymphocyte activation, and antigen recognition.
|
| G4149 |
AF488 Anti-Mouse CD4 (GK1.5) mAb |
The CD4 antigen is a 55 kDa cell surface type I membrane glycoprotein belonging to the immunoglobulin superfamily. CD4 acts as a co-receptor which, in cooperation with the T cell receptor (TCR), interacts with class II MHC molecules displayed by antigen-presenting cells (APC). CD4 is expressed by the majority of thymocytes, most helper T cells, a subset of NK-T cells, and weakly by dendritic cells and macrophages. CD4 plays an important role in the development of T cells and is required for mature T cells to function optimally. |
| G0534 |
AF488 Anti-Mouse CD49b (DX5) mAb |
CD49b is a 150 kDa transmembrane glycoprotein that non-covalently associates with CD29 (integrin β1) to form the integrin α2β1 complex known as VLA-2. The rat anti-mouse CD49b antibody has been reported to identify the majority of NK cells and a small T-cell subpopulation in most mouse strains (e.g., A/J, AKR, BALB/c, C3H/HeJ, C57BL/6, C57BL/10, C57BR, C58, CBA/Ca, DBA/1, DBA/2, SJL, SWR, 129/J, but not NOD). The DX5 antibody also recognizes platelets that express high levels of CD49b. |
| G0549 |
AF488 Anti-Mouse CD49b (HMα2) mAb |
CD49b is a 150 kD glycoprotein, also known as α2 integrin, VLA-2 α chain, Integrin α2 chain, and HMα2. It is a member of the integrin family, expressed on NK cells, a subset of splenic CD4+ T cells, NK-T cells, intestinal intraepithelial and lamina propria lymphocytes, epithelial cells, and platelets. By associating with CD29 (integrin β1 subunit), CD49b forms the VLA-2 (integrin α2β1 ) complex. It plays a critical role in both adhesion and lymphocyte activation. The primary ligands for CD49b are collagen, laminin, and fibronectin. |
| G1119 |
AF488 Anti-Mouse CD54 (YN1/1.7.4) mAb |
CD54 is a 90 kD immunoglobulin superfamily member also known as ICAM-1 and Ly-47. It is expressed on activated endothelial cells, high endothelial venules (HEV), T and B cells, monocytes/ macrophages, granulocytes, and dendritic cells. CD54 is an important intracellular adhesion molecule that participates in T cell-T cell, T cell-B cell, and T cell-target cell interactions via binding of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). CD54 has also been shown to be involved in lymphocyte trafficking, making it an important molecule in many immune reactions and inflammation. CD54 is also a receptor for rhinovirus. Antibodies against CD54 can block its interaction with LFA-1 and Mac-1, thereby inhibiting cell-cell adhesion, impairing antigen prese |
| G0384 |
AF488 Anti-Mouse CD73 (TY/23) mAb |
The antibody reacts with CD73 or Ecto-5'-nucleotidase (5'-NT), a 69 kDa GPI-anchored cell-surface protein with enzymatic and signal transduction activities. 5'-NT catalyzes the dephosphorylation of extracellular nucleoside 5' monophosphates into a form which can enter cells to meet their metabolic needs. It also regulates the concentration of extracellular adenosine, which initiates a variety of physiological responses through the adenosine receptors in many tissues. CD73 expression appears to be developmentally regulated on leukocytes. In the bone marrow, it is found on most CD11b+ myeloid cells and very few CD19+ cells of the B-lymphocyte lineage. It is not found on CD11b+ cells in the periphery nor on marrow-derived GMCSF-stimulated dend |
| G4419 |
AF488 Anti-Mouse CD86 (GL1) mAb |
CD86, along with CD80, is a member of the B7 family of costimulatory molecules and plays a crucial role in T cell activation and immune response regulation. CD86 is expressed at low levels on B cells, macrophages, and dendritic cells, and its expression is upregulated on B cells through various stimuli, including the BCR complex, CD40, and certain cytokine receptors. As a type I membrane protein and member of the immunoglobulin superfamily, CD86 serves as a ligand for the T cell surface proteins CD28 and CTLA-4 (CD152). The interaction between CD86 and CD28 provides a costimulatory signal essential for T cell activation during antigen presentation, while binding with CTLA-4 negatively regulates T cell activation, diminishing the immune resp |
| G1059 |
AF488 Anti-Mouse CX3CR1 (SA011F11) mAb |
CX3CR1 is a 40 kD, G-protein coupled receptor, with seven transmembrane regions. CX3CR1 is expressed by resident and alternatively activated macrophages (M2), a subset of monocytes, dendritic cells (DCs), NK cells, a subset of memory T cells, and mast cells. CX3CR1 is involved in cell recruitment during inflammation and participates in cell adhesion and extravasation from blood vessels. Its ligand is CX3CL1, also known as fractalkine or neurotactin. CX3CR1 is also a coreceptor for HIV1 and variations in this gene leads to increased susceptibility to HIV. In the brain, it is expressed by glial cells, which interact with CX3CL1 expressed by neurons. |
| G1809 |
AF488 Anti-Mouse H-2Kb (AF6-88.5) mAb |
H-2Kb is a mouse MHC class I alloantigen expressed on all nucleated cells of mice with the H-2^b haplotype. It plays a key role in presenting endogenous peptides to CD8+ T cells, enabling immune surveillance and cytotoxic T cell responses. |
| G4224 |
AF488 Anti-Mouse IL-4 (11B11) mAb |
IL-4 (interleukin-4) is a multifunctional 14 kDa cytokine. IL-4 is mainly produced by activated Th2 and NK cells, with smaller contributions from mast cells and basophils. It signals via the IL-4Rα receptor. Once bound to its receptor, IL-4 promotes the proliferation of activated B and T cells and drives B cell differentiation into plasma cells. It also facilitates class switching to IgE in B cells and enhances MHC class II expression, while suppressing Th1 cell development, macrophage activity, IFNγ production, and IL-12 release by dendritic cells. IL-4, like other cytokines associated with Th2 responses, contributes to airway inflammation commonly seen in allergic asthma. |
| G4314 |
AF488 Anti-Mouse LFA-1α/CD11a (M17/4) mAb |
LFA-1α (lymphocyte function-associated antigen 1 alpha), also known as integrin alpha L chain and CD11a, pairs with CD18 to form LFA-1, a 180 kDa integrin glycoprotein belonging to the integrin family. LFA-1 is expressed on the surface of all leukocytes, including lymphocytes, monocytes, macrophages, and granulocytes. It plays a central role in leukocyte intercellular adhesion through interactions with its ligands ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50), and also contributes to lymphocyte costimulatory signaling. |
| G4434 |
AF488 Anti-Mouse Ly6G (1A8) mAb |
Lymphocyte antigen 6 complex, locus G (Ly-6G), is a 21–25 kDa GPI-anchored protein expressed primarily on peripheral granulocytes and highly specific for neutrophils. Ly-6G serves as a robust marker for neutrophil identification and depletion in mice. Ly-6G modulates neutrophil migration and recruitment to sites of inflammation via interaction with β2 integrins. Its downregulation is associated with age-related functional decline in neutrophils. |
| G4344 |
AF488 Anti-Mouse Ly6G/Ly6C (RB6-8C5) mAb |
Lymphocyte antigen 6 complex, locus G (Ly-6G), also known as Ly6C, Gr-1, is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein with a molecular weight of approximately 21–25 kDa. It is commonly used as a specific marker for peripheral granulocytes, particularly neutrophils, in mice. Ly-6G is predominantly expressed on myeloid-derived cells in the bone marrow and exhibits high specificity for neutrophils, though it can also be detected on some monocytes and granulocyte subsets. This specificity makes Ly-6G a robust marker for identifying and studying neutrophil populations and their roles in immune responses in murine models. |
| G4254 |
AF488 Anti-Mouse NK1.1 (PK136) mAb |
NK1.1, also known as CD161b/CD161c, KLRB1, NKR-P1A, and Ly-55, is a type II integral membrane glycoprotein with a C-type lectin domain and is encoded by the Klrb1c/NKR-P1C gene. NK1.1 plays roles in NK cell activation and differentiation, IFN-γ production, cytotoxic granule release, and is thought to be involved in the generation of Th2 cells. NK1.1 is predominantly expressed as a disulfide-linked homodimer on NK cells; however, it is also expressed on NK-T cells, a rare population of T lymphocytes. NK1.1 is only expressed by C57BL/6, FVB/N, and NZB strains of mice and not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129 strains. |
| G1674 |
AF488 Anti-Mouse TCR Vα2 (B20.1) mAb |
TCR Vα2 is a distinct T-cell receptor (TCR) subfamily found in mice with the a, b, and c haplotypes. The TCR α chain complexes with the TCR β chain in 95% of T cells, forming the T cell receptor (α/β TCR), while the remaining 5% of T cells express gamma (γ) and delta (δ) chains (γ/δ TCR). TCR Vα2 represents a specific variant of the TCR α chain that plays a role in antigen recognition and is useful in the study of T-cell function and immune responses in mice with these specific haplotypes. |
| G4359 |
AF488 Anti-Mouse Ter-119 (TER-119) mAb |
TER-119 is a lineage marker for erythroid cells from early proerythroblast to mature erythrocyte stages in adult blood, spleen, and bone marrow. It is also present in yolk sac, and fetal and newborn liver. The TER-119 antigen is not expressed by cells of earlier erythroid development at BFU-e (blast-forming unit erythroid) stage or CFU-e (colony-forming unit erythroid) stage. |
| G2034 |
AF488 Anti-Mouse/rat CD81 (Eat-2) mAb |
CD81 is a 26 kD non-glycosylated member of the tetraspanin superfamily (TM4SF), also known as TAPA-1. CD81 is expressed on T and B cells, NK cells, dendritic cells, thymocytes, endothelial cells, and fibroblasts. CD81 induces B cell adhesion via the VLA-4 integrin and has been shown to play a role in early T cell development. CD81 associates with several other cell-surface proteins in a multimolecular complex, including CD19, CD21, CD20, CD37, CD53, and CD82 in B cells, and CD4, CD8 and CD82 in T cells. |
| G1299 |
AF488 Anti-Podoplanin(L7B2) mAb |
Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin type-1 glycoprotein with a 40-43 kDa molecular weight. Podoplanin is expressed in many tumors and normal cells, especially lymphatic epithelial cells and follicular DCs. Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. Podoplanin appears to serve as a ligand for CLEC-2 and expression is positively correlated with tumors expressing greater invasive and metastatic potential. Podoplanin is directly involved in cell migration, aids metastases formation and tumor cell invasion of tissue. Further, it has also been determined that |
| G4029 |
AF488 Anti-TCF1/TCF7 (E19C1) mAb |
LEF1 and TCF are members of the high mobility group (HMG) DNA-binding protein family of transcription factors that consists of the following: Lymphoid Enhancer Factor 1 (LEF1), T Cell Factor 1 (TCF1/TCF7), TCF3/TCF7L1, and TCF4/TCF7L2. LEF1 and TCF1/TCF7 were originally identified as important factors that regulate early lymphoid development and act downstream in Wnt signaling. LEF1 and TCF bind to Wnt response elements to provide docking sites for β-catenin, which translocates to the nucleus to promote the transcription of target genes upon activation of Wnt signaling. LEF1 and TCF are dynamically expressed during development and aberrant activation of the Wnt signaling pathway is involved in many types of cancers, including colon cancer. |
| G0924 |
AF488 Anti-TCR gammadelta(J18P6) mAb |
TCR gamma/delta (T-cell receptor gamma/delta) are specialized T-cells in the immune system. The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflamm |
| G0294 |
AF488 Anti-TCR-β (H57-597) mAb |
The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system c |
| G3864 |
AF488 Anti-Zap-70 (A12A8) mAb |
The Syk family protein tyrosine kinase Zap-70 is expressed in T and NK cells and plays a critical role in mediating T cell activation in response to T cell receptor (TCR) engagement. Following TCR engagement, Zap-70 is rapidly phosphorylated on several tyrosine residues through autophosphorylation and transphosphorylation by the Src family tyrosine kinase Lck. Tyrosine phosphorylation correlates with increased Zap-70 kinase activity and downstream signaling events. Expression of Zap-70 is correlated with disease progression and survival in patients with chronic lymphocytic leukemia. |
| G4194 |
AF488 Mouse IgG1 isotype control (MOPC-21) |
Mouse IgG1 isotype control is a mouse myeloma protein. It was selected as an isotype control following screening for low background on a variety of mouse and human tissues. |
| G0639 |
AF488 Rat IgG2a kappa Isotype Control (eBR2a) |
Rat IgG2a is an immunoglobulin subclass that is commonly used in research and diagnostic applications. It is produced by the rat immune system and is known for its ability to activate complement and mediate antibody-dependent cell-mediated cytotoxicity (ADCC). Rat IgG2a has a molecular weight of approximately 160 kDa and is composed of two heavy chains and two light chains. It is often used as a control or reference antibody in experiments involving rat models, and is also commonly used in flow cytometry and immunohistochemistry applications.
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| G0894 |
AF488 Rat IgG2b kappa Isotype Control (eB149/10H5) |
Rat IgG2b is a protein-coding gene that encodes for the immunoglobulin G2b (IgG2b) subclass of rat antibodies. IgG2b is a major subclass of rat immunoglobulins that plays a crucial role in the immune response by neutralizing pathogens and promoting opsonization. Rat IgG2b is commonly used in research applications, such as in immunohistochemistry, flow cytometry, and Western blotting.
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| G0104 |
AF532 Anti-CD11c (N418) mAb |
CD11, along with CD18, form a heterodimer adhesion molecule. In particular, CD11 is composed of CD11a, CD11b and CD11c. CD11a is a leukocyte marker that is expressed in B and T lymphocytes, macrophages, monocytes, neutrophils, basophils and eosinophils. CD11b is primarily expressed by monocytes, macrophages, natural killer cells, some B and T-cells, and granulocytes. CD11c is expressed in monocytes, macrophages, natural killer cells, some granulocytes and less so in a subset of lymphocytes. |
| G0029 |
AF532 Anti-CD45 (30-F11) mAb |
CD45, also known as Leukocyte Common Antigen (LCA). CD45 is expressed by all hematopoietic cells excluding mature erythrocytes and platelets. The cytoplasmic portion of CD45 has tyrosine phosphatase enzymatic activity and plays an important role in activation of lymphocytes.
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| G0014 |
AF532 Anti-CD8a (53-6.7) mAb |
CD8 (Cluster of differentiation 8), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, plays an integral role in signal transduction, and T cell differentiation and activation. CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8alpha and CD8beta, where it functions as a co-receptor, along with T cell receptor (TCR), for major histocompatibilty complex class I (MHC-I) molecules; whereas its counterpart, CD4, acts as a co-receptor for MHC-II molecules. CD8 exists on the cell surface, where the CD8alpha chain is essential for binding to MHC-I. CD8 is also expressed on a subset of T cells, NK cells, monocytes and dendritic cells as disulfide-linked homodimers of CD8alpha. Ligation of MH |
| G0044 |
AF532 Anti-FOXP3 (FJK-16s) mAb |
FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-alle |
| H0149 |
AF532 Anti-Human CD11c (3.9) mAb |
CD11c is a 145–150 kDa type I transmembrane glycoprotein also known as integrin αx and CR4. CD11c non-covalently associates with integrin β2 (CD18) and is expressed on monocytes/macrophages, dendritic cells, granulocytes, NK cells, and subsets of T and B cells. CD11c has been reported to play a role in adhesion and CTL killing through its interactions with fibrinogen, CD54, and iC3b. |
| H4289 |
AF532 Anti-Human CD3 (OKT-3) mAb |
CD3ε is one of five polypeptide chains that combine to form the TCR complex. CD3ε is expressed on T lymphocytes, NK-T cels, and to varying degrees on developing thymocytes. CD3 plays roles in TCR signaling, T lymphocyte activation, and antigen recognition. |
| H0104 |
AF532 Anti-Human CD45 (HI30) mAb |
CD45 is encoded by the PTPRC (Protein tyrosine phosphatase receptor type C) gene. CD45, also known as the leukocyte common antigen (LCA), is a member of the protein tyrosine phosphatase (PTP) family. It is present on all human leukocytes including lymphocytes, monocytes, granulocytes, eosinophils, and thymocytes. CD45 is absent from circulating erythrocytes, platelets, or mature erythroid cells of bone marrow and non-hemopoietic tissues. |
| G0329 |
AF532 Anti-Ki-67 (SolA15) mAb |
Ki-67 is a nuclear protein that is expressed during various stages in the cell cycle, particularly during late G1, S, G2, and M phases. The protein has a forkhead associated domain (FHA) through which it associates with euchromatin at the perichromosomal layer, the centromeric heterochromatin, and the nucleolus. Ki-67 is shown to have a cell cycle dependent topographical distribution with perinucleolar expression at G1, expression in the nuclear matrix at G2, and expression on the chromosomes during M phase. Ki-67 is commonly used as a proliferation marker because it is not detected in G0 cells, but increases steadily from G1 through mitosis. Ki-67 antibodies are useful in establishing the cell growing fraction in neoplasms. In neoplastic t |
| G4649 |
AF532 Anti-Mouse CD3 (17A2) mAb |
CD3ε is one of five polypeptide chains that combine to form the TCR complex. CD3ε is expressed on T lymphocytes, NK-T cels, and to varying degrees on developing thymocytes. CD3 plays roles in TCR signaling, T lymphocyte activation, and antigen recognition. |
| G4349 |
AF532 Anti-Mouse Ly6G/Ly6C (RB6-8C5) mAb |
Lymphocyte antigen 6 complex, locus G (Ly-6G), also known as Ly6C, Gr-1, is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein with a molecular weight of approximately 21–25 kDa. It is commonly used as a specific marker for peripheral granulocytes, particularly neutrophils, in mice. Ly-6G is predominantly expressed on myeloid-derived cells in the bone marrow and exhibits high specificity for neutrophils, though it can also be detected on some monocytes and granulocyte subsets. This specificity makes Ly-6G a robust marker for identifying and studying neutrophil populations and their roles in immune responses in murine models. |
| G0899 |
AF532 Rat IgG2b kappa Isotype Control (eB149/10H5) |
Rat IgG2b is a protein-coding gene that encodes for the immunoglobulin G2b (IgG2b) subclass of rat antibodies. IgG2b is a major subclass of rat immunoglobulins that plays a crucial role in the immune response by neutralizing pathogens and promoting opsonization. Rat IgG2b is commonly used in research applications, such as in immunohistochemistry, flow cytometry, and Western blotting.
|
| G3462 |
AF647 Anti-CD105/Endoglin (MJ7/18) mAb |
CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up-regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation-associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2. |
| G0267 |
AF647 Anti-CD105/Endoglin (SN6) mAb |
CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2. |
| G4062 |
AF647 Anti-CD117/c-Kit (2B8) mAb |
KIT (c-KIT), also known as CD117, is a proto-oncogene and a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). KIT was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT together with its ligand regulates growth and activation of a variety of hemopoietic and non-hemopoietic cells. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Recently, deregulation of the KIT receptor TK by the prevalent activation loop mutation D816V has served as a focal point in therapeutic strategies aimed at curbing neoplastic mast cell growth. c-Kit is expressed in hematopoietic stem cells, germ cell |
| G2082 |
AF647 Anti-CD11b+CD11c (OX42) mAb |
CD11b (Integrin αM) and CD11c (Integrin αX) are α-chain integrins that belong to the β2 integrin family. They are primarily expressed on myeloid cells, including monocytes, macrophages, dendritic cells, and neutrophils. These integrins play key roles in cell adhesion, migration, phagocytosis, and immune regulation through interactions with ligands such as iC3b, ICAM-1, and fibrinogen. CD11b is highly expressed on monocytes and neutrophils, whereas CD11c is widely used as a marker for dendritic cells. |
| G0102 |
AF647 Anti-CD11c (N418) mAb |
CD11, along with CD18, form a heterodimer adhesion molecule. In particular, CD11 is composed of CD11a, CD11b and CD11c. CD11a is a leukocyte marker that is expressed in B and T lymphocytes, macrophages, monocytes, neutrophils, basophils and eosinophils. CD11b is primarily expressed by monocytes, macrophages, natural killer cells, some B and T-cells, and granulocytes. CD11c is expressed in monocytes, macrophages, natural killer cells, some granulocytes and less so in a subset of lymphocytes. |
| G0462 |
AF647 Anti-CD127 (A7R34) mAb |
CD127, also known as the Interleukin-7 receptor alpha chain (IL-7Ralpha), is a type I glycoprotein with a molecular weight of 75-80 kDa. It forms a multi-functional receptor complex with CD132, the common gamma chain, to create the IL-7 receptor (IL-7R), which is crucial for lymphopoiesis. The active IL-7 receptor is an alpha/gamma chain heterodimer, where the gamma chain also associates with the interleukin-2 receptor and primarily activates signal transduction, while the alpha chain determines specific signaling events through its association with cytoplasmic signaling molecules. CD127 is expressed by immature B cells through the early pre-B stage, thymocytes during various stages of development, and most mature T cells, with transient do |
| H0342 |
AF647 Anti-CD161 (HP-3G10) mAb |
CD161, also known as NKR-P1A, is a type II transmembrane lectin-like receptor and member of the killer cell lectin-like receptor (KLR) family. CD161 exists as a homodimer and is prominently expressed on natural killer (NK) and NKT cells, where it is proposed to regulate the function of both cell types. CD161 is also found on T cell subsets, including T regulatory cells (Tregs), memory/effector CD4+ T cells, and CD8+ T cells. Th17 cells have been demonstrated to co-express CD161, as surface IL-17A+ cells are contained within the CD161+ fraction of CD4 T cells, so that CD161 (in combination with CCR6) is often used as a marker for enrichment of Th17 cells. |
| H1302 |
AF647 Anti-CD18 (YFC118.3) mAb |
CD18 is an integral membrane glycoprotein of ~95 kDa, also known as the beta 2 chain of the LFA-1 complex. CD18 non-covalently links to CD11a, b, or c molecules to form the heteromeric LFA-1 complex. CD18 acts as the receptor for ICAM-1 and is important for cell adhesion and cell-cell interactions. |
| G0612 |
AF647 Anti-CD184/CXCR4 (2B11) mAb |
CXCR4 (Fusin, LESTR, HUMSTR) is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains, and functions as a co-receptor for X4 HIV-1 entry into CD4+ cells. CXCR4 has been proved to be the co-receptor for HIV-2's binding to CD4 through envelope glycoprotein gp 120 and promotes Env-mediated fusion of the virus. In other cases, CXCR4 can even function as the only receptor for HIV-2's binding to the CD4 host cells. CXCR4 is the receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. CXCR4 acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced c |
| G1722 |
AF647 Anti-CD1d (1B1) mAb |
CD1d is a heavy chain associated with Beta 2 microglobulin on cortical thymocytes. Beta 2 microglobulin independent expression of CD1d has also been demonstrated on human intestinal epithelial cells. CD1d is the sole group 2 member of the CD1 family of major histocompatibility (MHC) like glycoproteins. The CD1d gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 |
| G2352 |
AF647 Anti-CD200R (OX-110) mAb |
Mouse CD200R is a 326 amino acid, ~48 kDa single pass type I transmembrane glycoprotein, expressed primarily by peripheral blood monocytes and neutrophils but also by other leucocytes including T-lymphocytes and mast cells. CD200-CD200R interaction may be involved in the control of myeloid cellular function. |
| G4137 |
AF647 Anti-CD23 (B3B4) mAb |
CD23 is a 45 kDa glycoprotein that serves as a low-affinity receptor for IgE, playing a crucial role in regulating IgE responses and B cell activation. It is expressed on mature B cells, mantle zone B cells, follicular dendritic cells, and at lower levels on T cells, NK cells, Langerhans cells, and platelets. CD23 expression is upregulated upon B cell activation, and its soluble forms are biologically active, acting as potent mitogenic factors. CD23 is strongly expressed on Epstein-Barr virus (EBV)-transformed B lymphoblasts and is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells. It is also detected in neoplastic cells from cases of B cell chronic lymphocytic leukemia and some centroblastic/centrocytic lym |
| G0282 |
AF647 Anti-CD24 (M1/69) mAb |
CD24 is a 35-50 kDa glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed on a variety of cell types, including erythrocytes, thymocytes, peripheral lymphocytes, and cells of the myeloid lineage. It is variably glycosylated, resulting in heterogeneity in molecular mass across different cell lineages, which can affect antibody staining levels on lymphocyte populations. In the context of B-cell development, CD24 is expressed from the pro-B-cell stage in the bone marrow through to mature, surface Ig-positive B cells, with very low or negative expression on plasma cells. It is also present on the majority of B-lineage acute lymphoblastic leukemias, B-cell chronic lymphocytic leukemias (CCLs), and B-cell non-Hodgkin's lymphomas. CD2 |
| H0177 |
AF647 Anti-CD27 (O323) mAb |
CD27 (TNFRSF7) is a cell surface homodimer of ≥55 kDa subunits that provides co-stimulatory signaling in support of T cell (TCR) and B cell (BCR) receptors. Compared to CD28, whose TCR co-stimulatory signal can trigger cell proliferation, CD27 signaling promotes cell survival and differentiation to effector/memory stages. CD27 may be shed following interaction with its ligand CD70, which is typically expressed on activated dendritic cells, T cells, and B cells. In B cells, CD27 is a phenotypic marker for memory B cells and has also been included among markers for identifying B regulatory cells (Bregs), which regulate CD4+ T cell proliferation and Foxp3/CTLA-4 expression in Treg cells. |
| G1107 |
AF647 Anti-CD278 (C398.4A) mAb |
ICOS, also known as inducible costimulatory molecule and H4, is a 47-57 kD protein. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes. It is able to costimulate T cells proliferation. In addition, ICOS is involved in humoral immune responses (B cell germinal center formation). The ICOS ligand is B7h/B7RP-1 or B7-H2. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development. |
| H0702 |
AF647 Anti-CD284/TLR4 (HTA125) mAb |
TLR4 is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This receptor is most abundantly expressed in placenta, and in the myelomonocytic subpopulation of leukocytes. Mammalian cells respond to LPS by activating TLR4. TLR4 belongs to the multi-protein complex of the lipopolysaccharide (LPS) receptor, containing CD14, LY96, and TLR4, and is involved in signal transduction events induced by LPS found in most gram-negative bacteria. TLR4 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents and |
| G0207 |
AF647 Anti-CD31/PECAM-1 (390) mAb |
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulatio |
| H3612 |
AF647 Anti-CD324/E-Cadherin (DECMA-1) mAb |
Like the other cadherin family members P and N cadherin, E-cadherin is a transmembrane glycoprotein involved in intercellular adhesion. These proteins share a common basic structure. The extracellular portions of the proteins are largely composed of repeating domains, each with two consensus Ca2+-binding motifs. The cytoplasmic domain interacts with a-, b-, and g-catenins and actinins. These catenins connect E-cadherin with the cytoskeleton. Expression is found in most epidermal cells including melanocytes and kerotinocytes. E-cadherin is localized at the intercellular boundaries of epithelial cells in several tissues, and is thought to play a role in maintenance of tissue integrity. Loss of E-cadherin function has been implicated in the pr |
| G4107 |
AF647 Anti-CD326/EpCAM (G8.8) mAb |
Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA), also known as CD326, is a transmembrane glycoprotein expressed in the epithelium with a molecular weight of approximately 40 kDa, which functions as an epithelial cell adhesion molecule. Ep-CAM functions as a homotypic calcium-independent cell adhesion molecule, and has a direct impact on cell cycle, proliferation and metabolism of epithelial cells and fibroblasts due to its ability to rapidly induce the proto-oncogene c-myc and the cell cycle regulating genes cyclin A and E. Ep-CAM mediates Ca2+-independent homotypic interactions. Formation of Ep-CAM-mediated adhesions have a negative regulatory effect on adhesions mediated by classic cadherins, which may have strong |
| G0132 |
AF647 Anti-CD34 (RAM34) mAb |
CD34 is a highly glycosylated monomeric with a molecular weight range of 111-115 kDa surface protein that is present on many stem cell populations. CD34 is a stem cell marker although its expression on human hematopoietic stem cells is reversible. CD34 may serve as a surface receptor that undergoes receptor-mediated endocytosis and regulates adhesion, differentiation and proliferation of hematopoietic stem cells and other progenitors. CD34 expression is likely to represent a specific state of hematopoietic development that may have altered adhering properties with expanding and differentiating capabilities in both in vitro and in vivo conditions. CD34 is possibly an adhesion molecule with a putative role for mediating the attachment of stem |
| G0087 |
AF647 Anti-CD44 (IM7) mAb |
CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential. CD44 is expressed by hematopoietic, non-hematopoietic cells, epithelial tissu |
| G0027 |
AF647 Anti-CD45 (30-F11) mAb |
CD45, also known as Leukocyte Common Antigen (LCA). CD45 is expressed by all hematopoietic cells excluding mature erythrocytes and platelets. The cytoplasmic portion of CD45 has tyrosine phosphatase enzymatic activity and plays an important role in activation of lymphocytes.
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| G0357 |
AF647 Anti-CD45.1 (A20) mAb |
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides t |
| G0117 |
AF647 Anti-CD45R/B220 (RA3-6B2) mAb |
CD45R (PTPRC) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. CD45 contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. CD45 is specifically expressed in hematopoietic cells and has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists in multiple isoforms as a result of alternative splicing, and these isoforms di |
| G3492 |
AF647 Anti-CD5 (53-7.3) mAb |
CD5 is a 67 kDa human T-lymphocyte single-chain transmembrane glycoprotein. CD5 is present on all mature T-lymphocytes, on most of thymocytes and on many T-cell leukemias and lymphomas. CD5 also reacts with a subpopulation of activated B-cells and may act as a receptor in regulating T-cell proliferation. CD5 is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. CD5 is expressed by many T cell leukemia, lymphomas, and activated T cells. Diseases associated with CD5 dysfunction include thymus cancer and Richter's Syndrome. |
| G1902 |
AF647 Anti-CD51/Integrin αV (RMV-7) mAb |
ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8, 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands, the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. The ITGB3 protein product is the in |
| G0252 |
AF647 Anti-CD62L/L-Selectin (MEL-14) mAb |
The human CD62L is a 74-95 kDa glycoprotein member of the selectin family of adhesion receptors. L-Selectin is comprised of an aminoterminal C-type lectin binding domain, an epidermal growth factor-like domain, two short consensus repeat (SCR) sequences homologous to those found in complement binding proteins, a short spacer region, a transmembrane region and a short cytoplasmic region. Human CD62L (L-Selectin) is constitutively expressed on all classes of leukocytes including lymphocytes (except a substantial population of memory T cells), monocytes and polymorphonuclear cells. |
| G0492 |
AF647 Anti-CD68 (ED1) mAb |
CD68 antibody recognizes the rat ED1 antigen, a heavily glycosylated protein of ~90 -110 kDa, also known as rat CD68. The ED1 antigen is expressed on most macrophages populations, as well as on monocytes and is considered as a pan-macrophage marker in the rat. ED1 is expressed predominantly on the lysosomal membrane and lightly on the cell surface. The expression of ED1 antigen being predominantly cytoplasmic, flow cytometry results are improved by the use of a membrane permeabilization procedure, such as Leucoperm, prior to staining. |
| G0507 |
AF647 Anti-CD68 (FA-11) mAb |
CD68 is considered a pan-macrophage marker, predominantly expressed on the intracellular lysosomes of tissue macrophages/monocytes, including Kupffer cells, microglia, histiocytes and osteoclasts, and is expressed to a lesser extent by dendritic cells and peripheral blood granulocytes. CD68 is expressed by many tumor types including some B cell lymphomas, blastic NK lymphomas, melanomas, granulocytic (myeloid) sarcomas, hairy cell leukemias, and renal, urinary and pancreatic tumors, and can be used to demonstrate the presence/localization of macrophages. |
| G0222 |
AF647 Anti-CD80/B7-1 (16-10A1) mAb |
CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28, and of an inhibitory receptor CTLA-4 (CD152). Both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, and both molecules can also substitute for each other in this process. CD80 is rapidly induced on the surface of in vitro activated B cells, with Epstein Barr Virus (EBV) transformed B cell lines, with Burkitts lymphoma cell lines, with freshly isolated follicular B lymphoma cells, T cells, and monocytes. The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 and CTLA4 ligands of T cells. Diseases associated with CD80 dysfunct |
| G0012 |
AF647 Anti-CD8a (53-6.7) mAb |
CD8 (Cluster of differentiation 8), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, plays an integral role in signal transduction, and T cell differentiation and activation. CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8alpha and CD8beta, where it functions as a co-receptor, along with T cell receptor (TCR), for major histocompatibilty complex class I (MHC-I) molecules; whereas its counterpart, CD4, acts as a co-receptor for MHC-II molecules. CD8 exists on the cell surface, where the CD8alpha chain is essential for binding to MHC-I. CD8 is also expressed on a subset of T cells, NK cells, monocytes and dendritic cells as disulfide-linked homodimers of CD8alpha. Ligation of MH |
| H0777 |
AF647 Anti-FCER1A (AER-37 (CRA1)) mAb |
Fc epsilon RI alpha, also known as FcεRIα, is a subunit of the high-affinity receptor for IgE, primarily expressed on mast cells and basophils. Its expression is upregulated by the presence of IgE. FcεRIα forms a tetrameric complex with one beta and two gamma subunits, which are essential for signal transduction. The beta and gamma subunits contain immunoreceptor tyrosine-based activation motifs (ITAMs). The FcεRI complex plays a crucial role in triggering IgE-mediated allergic reactions.
When allergen-bound IgE molecules bring together two or more high-affinity IgE receptors, it leads to the release of mediators such as histamine, which are responsible for allergy symptoms.
This process couples allergens and mast cells to initiate inflamma |
| G0762 |
AF647 Anti-FCER1A (MAR-1) mAb |
Fc epsilon RI alpha, also known as FceR1 alpha, is a subunit of the high-affinity receptor for IgE, primarily expressed on mast cells and basophils. Its expression is upregulated by the presence of IgE. Fc epsilon RI alpha forms a tetrameric complex with one beta and two gamma subunits, which are essential for signal transduction. The beta and gamma subunits contain immunoreceptor tyrosine-based activation motifs (ITAMs). The Fc epsilon RI complex plays a crucial role in triggering IgE-mediated allergic reactions. When allergen-bound IgE molecules bring together two or more high-affinity IgE receptors, it leads to the release of mediators such as histamine, which are responsible for allergy symptoms. This process couples allergens and mast |
| H0402 |
AF647 Anti-Granzyme B (GB11) mAb |
Granzyme B is a member of the granzyme serine protease family, and is found in the granules of cytotoxic T cells and NK cells. Granzyme B has been described as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation, and CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells. Granzyme B is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. The receptor involved in this process has been identified as mannose 6-phosphate receptor which functions as a death receptor for Granzyme B during cytotoxic T cell-induced ap |
| G3747 |
AF647 Anti-HER2/ErbB2 (H24A7) mAb |
The ErbB2 (HER2) proto-oncogene encodes a 185 kDa transmembrane, receptor-like glycoprotein with intrinsic tyrosine kinase activity. While ErbB2 lacks an identified ligand, ErbB2 kinase activity can be activated in the absence of a ligand when overexpressed and through heteromeric associations with other ErbB family members. Amplification of the ErbB2 gene and overexpression of its product are detected in almost 40% of human breast cancers. Binding of the c-Cbl ubiquitin ligase to ErbB2 at Tyr1112 leads to ErbB2 poly-ubiquitination and enhances degradation of this kinase. ErbB2 is a key therapeutic target in the treatment of breast cancer and other carcinomas and targeting the regulation of ErbB2 degradation by the c-Cbl-regulated proteolyt |
| H0837 |
AF647 Anti-Human CD103/Integrin αE (Ber-ACT8) mAb |
CD103 is a type I transmembrane glycoprotein also known as αE integrin, integrin αIEL chain, and human mucosal lymphocyte antigen 1. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. Treg cells express high level of CD103. Hairy cell leukemia has also been shown to express CD103. The expression of CD103 on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as an αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD |
| H0462 |
AF647 Anti-Human CD107a (H4A3) mAb |
CD107a, also known as Lysosomal-associated membrane protein 1 (LAMP-1), is a ~110 kDa type I transmembrane protein that is heavily glycosylated and widely expressed by cells primarily on the luminal surface of their lysosomes. It is also expressed on the surface of activated platelets, activated lymphocytes, cytotoxic T cells and NK cells, and some tumor cell lines, including U937 and KG1a. LAMP-1 can serve as a ligand for E-selectin-mediated cell adhesion. LAMP-1 and LAMP-2 (CD107b) are carriers for poly-N-acetyllactosamines and are able to display sialyl Le[x] termini. |
| H0387 |
AF647 Anti-Human CD117 (104D2) mAb |
CD117 is a 145 kD protein tyrosine kinase also known as c-Kit. It is a receptor for stem cell factor or c-Kit ligand. CD117 is expressed on pluripotent hematopoietic progenitor cells (approximately 1-4% bone marrow cells), mast cells, and acute myeloid leukemia cells (AML). CD117 binding of c-Kit ligand induces phosphorylation of CD117 and stimulates proliferation and survival of primitive hematopoietic stem cells as well as erythroid-committed and granulo-monocytic committed cells. |
| H3327 |
AF647 Anti-Human CD11a (HI111) mAb |
This antibody specifically binds to CD11a, the 180 kDa integrin α chain. This type I transmembrane glycoprotein associates with CD18 (integrin β2) to form the heterodimeric glycoprotein CD11a/CD18. This heterodimer is also known as the lymphocyte (leukocytes) function associated antigen-1 (LFA-1) that is expressed on all leukocytes. LFA-1 is an adhesion molecule involved in lymphocyte and granulocyte functions. LFA-1 mediates adhesion of lymphoid cells to the vascular endothelium in association with its ligand, and the intracellular adhesion molecule-1 (ICAM-1), CD54. Other ligands are ICAM-2 (CD102) and ICAM-3 (CD50). Purified Mouse Anti-Human CD11a antibody also cross reacts with all leukocytes of baboon, and both rhesus and cynomolgus ma |
| H0072 |
AF647 Anti-Human CD11b (ICRF44) mAb |
CD11b is a 165-170 kD type I transmembrane glycoprotein also known as αM integrin, Mac-1, CR3, and C3biR. CD11b non-covalently associates with integrin β2 (CD18) and is expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b/CD18 is critical for the transendothelial migration of monocytes and neutrophils. It is also involved in granulocyte adhesion, phagocytosis, and neutrophil activation. CD11b/CD18 interacts with ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4, CD14, CD23, heparin, iC3b, fibrinogen, and factor X. |
| H0147 |
AF647 Anti-Human CD11c (3.9) mAb |
CD11c is a 145–150 kDa type I transmembrane glycoprotein also known as integrin αx and CR4. CD11c non-covalently associates with integrin β2 (CD18) and is expressed on monocytes/macrophages, dendritic cells, granulocytes, NK cells, and subsets of T and B cells. CD11c has been reported to play a role in adhesion and CTL killing through its interactions with fibrinogen, CD54, and iC3b. |
| H0492 |
AF647 Anti-Human CD127 (HIL-7R-M21) mAb |
CD127 is a 60–90 kDa glycoprotein, also known as the IL-7 receptor alpha (IL-7Rα) subunit. The IL-7 receptor complex is a heterodimer composed of CD127 and the common gamma chain (γc, CD132), shared by other cytokine receptors (IL-2R, IL-4R, IL-9R, IL-15R, and IL-21R). CD127 is expressed on thymocytes, T- and B-cell progenitors, mature T cells, and some lymphoid and myeloid cells. In vitro experiments show the expression of CD127 is down-regulated following T cell activation. Studies indicate that the IL-7 receptor plays an important role in the proliferation and differentiation of mature T cells. Recently, it has been shown that low surface expression of CD127, in combination with intermediate to high surface expression of CD25, the α chai |
| H3807 |
AF647 Anti-Human CD137 (4B4-1) mAb |
CD137 is a 39 kD transmembrane protein also known as 4-1BB. It is expressed on activated T cells. CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily. CD137 appears to be important for T cell proliferation and survival, and induces monocyte activation through its interaction with 4-1BB ligand. |
| H0192 |
AF647 Anti-Human CD14 (M5E2) mAb |
CD14 is a 53–55 kDa glycosylphosphatidylinositol (GPI)-anchored single-chain glycoprotein expressed at high levels on monocytes, macrophages, and neutrophils. CD14 is a multifunctional receptor and is constitutively expressed on the surface of mature monocytes and macrophages. It serves as a high-affinity receptor for lipopolysaccharide (LPS) and binds LPS in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute-phase serum protein. CD14 also exists in a soluble form (sCD14) and is released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. The soluble sCD14 is important for neutralizing allochthonous lipopolysaccharides by reconstituted lipoprotein particles and can discriminate structural dif |
| H1692 |
AF647 Anti-Human CD144/VE-cadherin (55-7H1) mAb |
Cadherin-5, a member of the cadherin family of calcium-dependent adhesion molecules, is also known as CD144 or VE-Cadherin. CD144 is expressed on endothelial cells in vivo and in vitro. It may play a role in the organization of lateral endothelial junctions and in the control of permeability properties of vascular endothelium. |
| H1047 |
AF647 Anti-Human CD146 (P1H12) mAb |
CD146, also known as MCAM, MUC18, or Mel-CAM, is a 118 kDa transmembrane glycoprotein and a member of the immunoglobulin superfamily. It is strongly expressed by blood vessel endothelium and smooth muscle. CD146 is also found on angioblasts, mesenchymal stem cells, melanoma cells, intermediate trophoblasts, and a subset of activated T cells. CD146 is widely used as a marker for endothelial cells and plays a key role in studies of angiogenesis, cancer progression, and vascular biology. |
| H1137 |
AF647 Anti-Human CD16 (3G8) mAb |
CD16a is a ~50–65 kDa type I transmembrane glycoprotein encoded by FCGR3A (Fc fragment of IgG receptor IIIa), which belongs to the immunoglobulin superfamily. CD16a is also known as Fc-gamma RIII-alpha (FcγRIIIA or FcRIIIa) and is expressed on natural killer (NK) cells, activated monocytes, macrophages, γδ T cells, immature thymocytes, and mast cells. CD16a binds immune-complexed or aggregated IgG and associates with CD247/TCRζ in NK cells and FcεRIγ chains in phagocytes and mast cells to transduce intracellular signals. CD16a functions in antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses including phagocytosis, cytokine production, or mediator release. CD16b is a ~48 kDa glycophosphatidylinositol (GPI)- |
| H3507 |
AF647 Anti-Human CD163 (GHI/61) mAb |
CD163 is also known as Scavenger receptor cysteine-rich type 1 protein M130 (M130), Hemoglobin scavenger receptor and Macrophage-associated antigen. CD163 is a 110-130 kDa transmembrane glycoprotein. CD163 is a monocyte/macrophage-restricted antigen expressed on the majority of tissue macrophages and peripheral blood monocytes. CD163 belongs to the scavenger receptor superfamily. Its expression on monocytes is upregulated upon cellular activation. CD163 expression reportedly changes on monocytes and macrophages as these cells differentiate. This finding suggests a role for this molecule in the differentiation and/or regulation of monocyte and macrophage function. CD163 may play a role in the clearance and endocytosis of hemoglobin and hapto |
| H2832 |
AF647 Anti-Human CD166/ALCAM (3A6) mAb |
CD166, also known as Activated Leukocyte Cell Adhesion Molecule (ALCAM) and the CD6 ligand, is a 100–105 kDa transmembrane glycoprotein belonging to the immunoglobulin superfamily. It consists of an immunoglobulin-like extracellular domain, a transmembrane region, and a short cytoplasmic tail. CD166 is expressed on neurons, activated T cells, activated monocytes, epithelial cells, and fibroblasts. It plays a key role in mediating adhesion interactions, particularly between thymic epithelial cells and CD6+ cells during intrathymic T-cell development. |
| H0012 |
AF647 Anti-Human CD19 (HIB19) mAb |
CD19 is a 95 kDa type I transmembrane glycoprotein expressed during all stages of B-cell maturation and differentiation, except on plasma cells. It is also present on follicular dendritic cells but not found on T cells or normal granulocytes. CD19 functions as a signal transduction molecule that regulates B cell development, activation, proliferation, and differentiation. It associates with complement receptor 2 (CD21), TAPA-1 (CD81), Leu 13, and/or MHC class II to form a signal transduction complex on the surface of B cells.
|
| H0027 |
AF647 Anti-Human CD19 (LT19) mAb |
CD19 is a type I transmembrane glycoprotein of 95 kDa that belongs to the immunglobulin superfamily. CD19 is expressed on B cells throughout most stages of B cell differentiation, though its expression is down-regulated during their terminal differentiation to plasma cells. Expression of CD19 is also found in the majority of B cell–derived malignancies. CD19 is further present on follicular dendritic cells. On B cells, CD19 associates with CD21, CD81, and CD225 (Leu-13) forming a signal transduction complex. |
| H1587 |
AF647 Anti-Human CD1a (HI149) mAb |
CD1a is a type I transmembrane glycoprotein. The 49 kDa CD1a polypeptide is associated with β2-microglobulin. CD1a is expressed on cortical thymocytes, dendritic cells and Langerhans cells. CD1a has structural similarities to the MHC class I antigen, and plays a role in antigen presentation. |
| H1602 |
AF647 Anti-Human CD1c (L161) mAb |
CD1c, also known as R7 or M241, is a 43 kD member of the five CD1 antigens (CD1a-e) in humans. The CD1 molecules are type I glycoprotein with structural similarities to MHC class I and are non-covalently associated with β2-microglobulin, belonging to the Ig superfamily. CD1c is expressed on cortical thymocytes, Langerhans cells, dendritic cells, and a subset of B cells. It has been reported that CD1c is also expressed on mature T cells in a tightly regulated manner. CD1c is involved in antigen-presentation of glycolipids. It may also act in T cells as an immune regulatory molecule. |
| H1167 |
AF647 Anti-Human CD20 (2H7) mAb |
CD20 is a 33-37 kD, four transmembrane spanning protein, also known as B1 and Bp35. CD20 is expressed on pre-B-cells, resting and activated B cells (not plasma cells), some follicular dendritic cells, and at low levels on a T cell subset. CD20 is heavily phosphorylated on activated B cells and malignant B cells. Homo-oligomeric complexes of CD20 are thought to form Ca2+ conductive ion channels in the plasma membrane of B cells. The CD20 molecule is involved in B-cell activation and is associated with various Src family kinases (Lyn, Lck, Fyn). It exists in a complex with MHC class I and II, CD53, CD81, and CD82. |
| H0327 |
AF647 Anti-Human CD24 (ML5) mAb |
CD24, also known as CD24A, signal transducer CD24, small cell lung carcinoma cluster 4 antigen, or BA-1, is a 35-70 kDa glycophosphatidylinositol (GPI)-linked glycoprotein. Its glycosylation pattern is highly variable and cell-type dependent. CD24 is expressed on neutrophils, eosinophils, dendritic cells, neural cells, epithelial cells, muscle cells, and many types of cancer cells. CD24 functions as an adhesion receptor. Several different ligands have been identified for CD24, including CD62P (P-selectin), which is expressed on activated platelets and activated endothelium. CD24 is variably expressed on all B lineage cells, except plasma cells, and can play a role in regulating the activation, proliferation, or differentiation of these cell |
| H4257 |
AF647 Anti-Human CD25 (M-A251) mAb |
The CD25 antigen is also known as the human low-affinity interleukin-2 receptor α chain (IL-2Rα) and the Tac antigen. The CD25antigen is present on a subset of peripheral blood lymphocytes. Antigen density increases on phytohemagglutinin (PHA)-, concanavalin A (Con A)-, and CD3-activated T lymphocytes; T lymphocytes from mixed lymphocyte cultures; and HTLV-infected T-lymphocyte leukemia lines, for example, HUT-102. Recombinant IL-2 blocks the binding of CD25 to PHA-activated T lymphocytes. CD4+/CD25+ regulatory T cells might directly regulate the function of responsive T cells. The CD25antibody is composed of mouse IgG1 heavy chains and kappa light chains |
| H4122 |
AF647 Anti-Human CD271/NGFR (ME20.4) mAb |
CD271, also known as p75NTR, TNFRSF16, p75(NTR), Gp80-LNGFR, and NGFR, is a type I transmembrane protein with a MW of 75 kD. It is expressed by many cell types including neurons, Schwann cells, mesenchymal stem/stromal cells, follicular dendritic cells and melanocytes. The extracellular portion contains four TNFR-Cys repeats that form the binding domain for its ligands (NGF, BDNF, NTF3, and NTF4). The intracellular portion of CD271 contains a death domain, which interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9, to promote cell apoptosis, and to regulate cell differentiation and neurogenesis. |
| H0447 |
AF647 Anti-Human CD279/PD-1 (EH12.2H7) mAb |
Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC) are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion. |
| H1767 |
AF647 Anti-Human CD294/CRTH2 (BM16) mAb |
CD294, also known as CRTH2, is a seven-transmembrane protein coupled with heterotrimeric G proteins. CRTH2 is the prostaglandin D2 receptor and is expressed by Th2 cells, eosinophils, and basophils. CD294 prevents the apoptosis of Th2 cells and mediates the chemotaxis of CRTH2 expressing cells to the sites of allergic inflammation, such as the asthmatic lung. |
| H0237 |
AF647 Anti-Human CD31 (WM59) mAb |
CD31 (PECAM-1), also known as GPIIA' or EndoCAM, is a 130 kDa type I transmembrane glycoprotein belonging to the Ig gene superfamily. It is widely expressed on platelets, monocytes, granulocytes, NK cells, T cell subsets, and in high amounts on endothelial cells. CD31 functions as a vascular endothelial cell adhesion molecule, playing a critical role in the transendothelial migration of leukocytes during inflammatory responses. It is also involved in thrombosis, angiogenesis, and wound healing. The antibody against PECAM-1 binds to an epitope near extracellular domain 2 of CD31.
Clone WM59 also cross-reacts with peripheral blood platelets and leukocytes of baboon, and both rhesus and cynomolgus macaque monkeys. The staining intensity of WM5 |
| H1407 |
AF647 Anti-Human CD314/NKG2D (1D11) mAb |
CD314, also known as NKG2D or KLRK1, is a 42 kDa type II transmembrane glycoprotein and a member of the C-type lectin family. It is expressed on human NK cells, as well as on virtually all TCR γ/δ+ and CD8+ TCR α/β+ T cells. NKG2D functions as an activating receptor that binds strongly to several ligands, including MICA, MICB, and ULBP-1, -2, and -3, which are expressed by different target cell types. Unlike other natural cytotoxicity receptors (NCR), NKG2D is not restricted to NK cells. It plays a critical role in natural cytotoxicity, aiding normal NK cells in attacking a variety of tumor or normal target cells. NKG2D can complement the role of NCR in tumor cell lysis, and combined masking of both NCR and NKG2D can lead to a complete inhi |
| H0927 |
AF647 Anti-Human CD33 (WM53) mAb |
CD33, also known as Sialic acid-binding Ig-like lectin 3 (Siglec-3), gp67, or p67, is a 67 kDa type I transmembrane glycoprotein expressed on monocytes, activated T cells, myeloid progenitors, and mast cells. CD33 is absent on normal platelets, lymphocytes, erythrocytes, and hematopoietic stem cells. This glycoprotein can reportedly function as a sialic acid-dependent cell adhesion molecule. This function can be modulated by endogenous sialoglycoconjugates when CD33 is expressed on the membrane. |
| H1782 |
AF647 Anti-Human CD337/NKp30 (P30-15) mAb |
The Human CD337/NKp30 monoclonal antibody recognizes CD337 also known as activating NK receptor NKp30 (NKp30), and natural cytotoxicity triggering receptor 3. NKp30 is a type I transmembrane protein, member of the natural cytotoxicity receptor family that contains one immunoglobulin-like domain. NKp30 has an apparent molecular weight of 30 kD and six isoforms are produced by alternative splicing. NKp30 is expressed on resting and activated NK cells. NKp30 enhances NK cell cytolysis of tumor cellts that are deficient in MHC class I molecules. NKp30 has been shown to associate with CD59 and TCRζ. The antibody is against human NKp30 has been shown to be useful for flow cytometry, stimulation of human NK cells via NKp30 in a redirected lysis as |
| H0042 |
AF647 Anti-Human CD4 (RPA-T4) mAb |
CD4 is a 56 kDa transmembrane glycoprotein expressed on the T-helper/inducer subset of normal human peripheral blood lymphocytes. The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex |
| H0567 |
AF647 Anti-Human CD40 (5C3) mAb |
CD40 is a 45–48 kDa type I transmembrane glycoprotein primarily expressed on B lymphocytes, though it is absent on terminally differentiated B cells. It is also found on endothelial cells, basal epithelial cells, certain epithelial cell carcinomas, follicular dendritic cells, macrophages, fibroblasts, keratinocytes, and CD34+ hematopoietic progenitor cells. CD40 plays a critical role in B-cell growth, proliferation, and differentiation, including immunoglobulin isotype switching. Engagement of CD40, particularly in the presence of IL-4 or costimulation with anti-µ or anti-CD20 antibodies, can promote B-cell proliferation.
|
| H0897 |
AF647 Anti-Human CD41a (HIP8) mAb |
CD41a, also known as Integrin αIIb or Platelet GPIIb, forms a calcium-dependent complex with CD61 (β3 integrin or GPIIIa) that is normally expressed on platelets and megakaryocytes. The CD41/CD61 complex serves as a receptor for fibrinogen, fibronectin, and von Willebrand factor, mediating platelet adhesion and aggregation. Blocking CD41 can completely inhibit ADP-, epinephrine-, and collagen-induced platelet activation, and partially inhibit ristocetin- and thrombin-induced activation. |
| H4047 |
AF647 Anti-Human CD42b (HIP1) mAb |
CD42b is also known as the Platelet glycoprotein Ib alpha chain that is encoded by the GP1BA gene. CD42b is disulfide bonded to CD42c to form a 170 kDa heterodimer, GPIb. GPIb forms a noncovalent complex with CD42a and CD42d (CD42 complex) that is expressed on platelets and megakaryocytes. The CD42 complex serves as the von Willebrand Factor (vWF) surface receptor involved in the adhesion of platelets to the subendothelium of damaged vascular walls. This antibody inhibits the ristocetin-dependent binding of vWF to platelets and partially inhibits collagen-induced aggregation. |
| H0747 |
AF647 Anti-Human CD45RA (HI100) mAb |
CD45RA, a 220 kDa isoform of the human leukocyte common antigen, is expressed on approximately 40–50% of peripheral CD4+ T cells, 50% of peripheral CD8+ T cells, and on a portion of B cells and monocytes. The CD45RA antigen is expressed by naïve and activated T cells. CD45RA-specific antibodies are useful for the study of the suppressor/inducer subpopulation of CD4+ lymphocytes. |
| H0537 |
AF647 Anti-Human CD49f (GoH3) mAb |
CD49f, also known as the integrin α6 chain, is a ~150 kDa type I transmembrane glycoprotein that belongs to the integrin alpha chain family of extracellular matrix and cell adhesion receptors. The integrin α6 subunit associates with the integrin β1 chain (CD29) to form VLA-6, and with the integrin β4 chain (CD104) to form the integrin α6β4 complex, also known as the laminin and kalinin receptor. CD49f is expressed mainly on T cells, monocytes, platelets, epithelial cells, endothelial cells, perineural cells, and trophoblasts of the placenta. Antibodies against CD49f can block the binding of integrin α6 to laminin P1 and E8 fragments. |
| H3987 |
AF647 Anti-Human CD5 (UCHT2) mAb |
CD5, also known as Leu-1, Ly-1 and T1, is a 67 kD single chain type I glycoprotein that is a member of the scavenger receptor superfamily. CD5 is expressed on T cells, thymocytes, B cell subsets, chronic B lymphocytic leukemia (B-CLL), and peripheral blood dendritic cells. CD5 modulates T and B cell receptor signaling, thymocyte maturation, and T-B cell interactions. One of its ligands is CD72. |
| H1257 |
AF647 Anti-Human CD54 (HA58) mAb |
CD54, also known as Intercellular Adhesion Molecule 1 (ICAM-1), is an 85-110 kDa type I transmembrane glycoprotein that belongs to the immunoglobulin supergene family. A soluble form of CD54 can also be found in biological fluids. CD54 is expressed on endothelial cells, as well as on both resting (weak) and activated (moderate) lymphocytes and monocytes. It serves as a ligand for LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). The CD54 adhesion molecule plays a key role in inflammatory and immune responses, as well as in neoplasia. |
| H4272 |
AF647 Anti-Human CD56/NCAM-1 (B159) mAb |
CD56 is a heavily glycosylated adhesion protein that is present on a subpopulation of peripheral blood large granular lymphocytes that demonstrate natural killer activity. CD56 is also expressed on a subset of T cells but is not expressed on myeloid cells, erythrocytes or B cells. This antigen is a pan-NK-cell marker. CD56 is virtually identical to an isoform of the neural cell adhesion molecule (NCAM), a structure mediating homotypic and heterotypic cell-cell interactions. |
| H3972 |
AF647 Anti-Human CD61 (VI-PL2) mAb |
CD61 is a 105 kDa transmembrane glycoprotein that is also known as integrin β3 and platelet glycoprotein IIIa (GPIIIa or GP3A). It is expressed on platelets, megakaryocytes, osteoclasts and endothelia. Integrin β3 associates with gpIIa (CD41) to form the CD41/CD61 complex which mediates platelet adhesion and aggregation. CD61 also associates with CD51 to form the CD51/CD61 complex (vitronectin receptor). CD61 appears to bind to fibrinogen, fibronectin, vWF, vitronectin, and thrombospondin to mediate cell adhesion. |
| H0297 |
AF647 Anti-Human CD62L (DREG-56) mAb |
CD62L (L-selectin) is a cell surface glycoprotein expressed on neutrophils, monocytes, T- and B-lymphocyte subsets, and NK cells. CD62L functions as a lymphocyte homing receptor, playing a key role in the migration of lymphocytes to peripheral lymph nodes via high endothelial venules (HEV). |
| H1332 |
AF647 Anti-Human CD63 (H5C6) mAb |
CD63 is a 53 kDa, type III lysosomal glycoprotein that belongs to the tetraspan transmembrane 4 superfamily (TM4SF). It is expressed on activated platelets, monocytes, and macrophages, and is also known by several other names, including LIMP, gp55, melanoma-associated antigen ME491, Pltgp40, and LAMP-3. CD63 is widely expressed on the surface and in the cytoplasm of various hematopoietic cells (such as monocytes and macrophages) as well as non-hematopoietic cells (including endothelium, fibroblasts, osteoclasts, and smooth muscle cells). It plays a key role in mediating cellular adhesion and motility. |
| H0522 |
AF647 Anti-Human CD68 (Y1/82A) mAb |
CD68, also known as Scavenger receptor class D member 1 (SCARD1), Macrosialin, or GP110, is a 110 kDa type I transmembrane glycoprotein primarily localized in cytoplasmic granules of monocytes, macrophages, dendritic cells, granulocytes, myeloid progenitor cells, and reportedly, a subset of CD34-positive hematopoietic bone marrow progenitor cells. CD68 belongs to the sialomucin family and functions as a scavenger receptor, capable of binding and internalizing oxidized low-density lipoproteins (LDL). Antibodies targeting CD68 are commonly used in studies of myeloid cell development and function. |
| H0552 |
AF647 Anti-Human CD8 (SK1) mAb |
CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck. |
| H1482 |
AF647 Anti-Human CD83 (HB15e) mAb |
CD83 is a 45 kDa type I transmembrane glycoprotein that belongs to the immunoglobulin (Ig) superfamily. It is composed of a single V-type Ig extracellular domain and a C-terminal cytoplasmic tail. CD83 is primarily expressed on the surface of follicular dendritic cells, circulating dendritic cells, interdigitating dendritic cells in lymphoid tissues, in vitro-generated dendritic cells, and thymic dendritic cells. However, its expression is not limited to dendritic cells; it is also found on some germinal center B cells and certain lymphoblastoid cell lines. While the exact function of CD83 is not fully understood, it is believed to play a role in cell-cell interactions during antigen presentation. |
| H1797 |
AF647 Anti-Human HLA-A2 (BB7.2) mAb |
HLA-A2 is a class I molecule of the major histocompatibility complex (MHC) and part of the highly polymorphic group of cell-surface proteins encoded by the MHC gene locus. It plays a crucial role in the immune response by binding and presenting small antigenic protein fragments to antigen-specific receptors on T cells (TCR). Class I MHC molecules, like HLA-A2, bind peptides derived from intracellular antigens, such as viral and some bacterial antigens, which are recognized by CD8+ T cells. The TCRs recognize these processed peptides bound to the MHC, as well as regions of the MHC molecule itself, while CD4 and CD8 accessory molecules enhance the interaction by binding non-polymorphic regions of the MHC. |
| H3702 |
AF647 Anti-Human IgD (IA6-2) mAb |
IgD is a member of the immunoglobulin superfamily that exists in type 1-membrane (mIgD) and soluble glycoprotein forms. mIgD is expressed on mature naïve B cells (along with membrane IgM) and serves as a B-cell receptor for antigen (BCR). In response to antigen binding, the mIgD BCR, in association with other signaling molecules including CD79a and CD79b, can transduce activating or tolerizing signals intracellularly into B lymphocytes. |
| H1017 |
AF647 Anti-Human IgM (MHM-88) mAb |
IgM is the first immunoglobulin made by B cells in the immune response. Surface IgM is expressed on immature and mature B cells, while IgM heavy (μ) chain is expressed intracellularly in pre-B cells. |
| H4407 |
AF647 Anti-human SSEA-4 (MC813) mAb |
The antibody reacts with Stage-Specific Embryonic Antigen-4 (SSEA-4), a carbohydrate epitope on the major ganglioside, but not the neutral glycolipid, of human teratocarcinoma cells. As its name implies, the expression of SSEA-4 is stage-specific and can be used to characterize embryonic cells and monitor their differentiation. However, its expression pattern differs in the human and mouse. In the human, SSEA-4 is found on teratocarcinoma (embryonal carcinoma or EC), embryonic inner cell mass (ICM), embryonic stem (ES) cells, and the K562 erythromyeloid leukeumia cell line. As human stem cells undergo differentiation, SSEA-4 expression is lost. In the mouse, SSEA-4 is found on oocytes and early cleavage-stage embryos, and primitive ect |
| H1857 |
AF647 Anti-Human TCR Vα7.2 (3C10) mAb |
The antibody recognizes the Vα7.2 T cell antigen receptor (TCR) α-chain segment which, joined with the Jα33 segment, constitutes an invariant TCR that is a characteristic of the mucosalassociated invariant T cells (MAIT cells). MAIT cells are restricted by a nonpolymorphic class Ib major histocompatibility complex (MHC) molecule, MHC-related molecule 1 (MR1). MAIT cells are present in human blood (1-8% of T cells), mesenteric lymph nodes, liver, and intestinal mucosa. MAIT cells play a role in detecting and fighting off microbial infections |
| H1497 |
AF647 Anti-Human TCR α/β (IP26) mAb |
TCR α/β is a monomorphic determinant of the α/β T-cell receptor, which is expressed on over 95% of normal peripheral blood CD3+ T cells. The α/β T-cell receptor (TCR) plays a crucial role in recognizing peptides bound to MHC molecules, leading to T-cell activation. |
| H0612 |
AF647 Anti-Human VEGFR2/KDR/Flk-1 (89106) mAb |
VEGFR2 (KDR/Flk-1), VEGFR1 (Flt-1), and VEGFR3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domains and kinase insert domains in their intracellular regions. The expression of VEGFR1, 2, and 3 is almost exclusively restricted to the endothelial cells. These receptors are likely to play essential roles in vasculogenesis and angiogenesis. VEGFR2 cDNA encodes a 1356 amino acid (aa) residue precursor protein with a 19 aa residue signal peptide. Mature VEGFR2 is composed of a 745 aa residue extracellular domain, a 25 aa residue transmembrane domain and a 567 aa residue cytoplasmic domain. In contrast to VEGFR1 which binds both P |
| H0132 |
AF647 Anti-IFN-lambda (4S.B3) mAb |
IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor and immune interferon that is produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemagglutinin, and other cytokines. IFN gamma is a dimeric protein consisting of two 146 amino acid subunits. IFN gamma is a glycoprotein that exists functionally as a homodimer of approximately 45 kDa. On SDS-PAGE, IFN gamma appears as a combination of 25, 20, and minor 15.5 kDa bands as a result of differential glycosylation. The biological activity of the IFN gamma homodimer is highly species specific. Human IFN gamma does not show cross-reactivity with mouse. IFN gamma exhibits functions such as a |
| G0372 |
AF647 Anti-Ly-6A/E/Sca-1 (D7) mAb |
Stem Cell Antigen-1 (Sca-1) is a member of the lymphocyte antigen 6 (Ly-6) family. It is expressed on multipotent hematopoietic stem cells (HSC) and is used as a marker of HSC in mice. Sca-1 is used in combination with lineage depletion antibodies to identify murine HSC. Sca-1 can be found in fetal liver, adult bone marrow, and adult peripheral blood and spleen. Sca-1 may be involved in the regulation of B and T cell activation. |
| G3477 |
AF647 Anti-Ly-6B.2 Alloantigen (7/4) mAb |
Rat anti Mouse Ly-6B.2 monoclonal antibody, recognizes the Ly-6B.2 antigen. Ly-6B.2 is a ~25-30 kDa GPI-anchored, heavily glycosylated protein expressed on neutrophils, inflammatory monocytes and some activated macrophages. High levels of expression are seen in bone marrow, spleen, lung and lymph nodes. N-glycanase treatment of thioglycollate elicited peritoneal neutrophil lysates lowers the apparent molecular weight of Ly-6B.2 to ~15 kDa. In common with other Ly-6 antigens Ly-6B.2 demonstrates a polymorphic expression on inbred mouse strains. Rat anti mouse Ly-6B.2, recognizes the Ly-6B.2 antigen in 129J; AKR; C57BL/6; C57BL/10; C58; DBA/2; NZB; NZW; SJL; MFI; Swiss (PO) Strains whilst A2G; A/Sn; ASW; BALB/c; C3H/HEH: CBA.T6T6 are negative |
| G0447 |
AF647 Anti-Mouse CD107a (1D4B) mAb |
CD107a, also known as Lysosome-Associated Membrane Protein 1 (LAMP-1), is a type I transmembrane glycoprotein that serves as a key marker of lysosomes. It is composed of a 40 kDa core protein that is heavily glycosylated, resulting in a mature glycoprotein ranging from 110 to 140 kDa. CD107a is predominantly expressed in epithelial cells and macrophages across various organs. Upon cellular activation, it translocates to the cell surface of lymphocytes, macrophages, epithelial cells, endothelial cells, platelets, and tumor cells. Surface expression of CD107a is involved in intercellular and extracellular matrix adhesion and is widely used as a functional marker of cytotoxic activity in NK cells and CD8+ T cells, as well as in identifying som |
| G4122 |
AF647 Anti-Mouse CD138 (281-2) mAb |
CD138 (Syndecan-1) is a transmembrane proteoglycan containing both heparan sulfate and chondroitin sulfate chains. It binds to components of the extracellular matrix and plays a critical role in cell adhesion, proliferation, and signaling. CD138 is predominantly expressed on epithelial cells, where its presence is associated with normal epithelial architecture. It is also expressed on B lymphocytes during specific stages of differentiation, including precursor B cells in the bone marrow and antibody-secreting plasma cells, but is absent on mature peripheral B cells. This expression pattern implicates CD138 in B cell–matrix interactions. Its expression is regulated during embryonic development and is subject to tissue-specific structural pol |
| G0987 |
AF647 Anti-Mouse CD146 (ME-9F1) mAb |
CD146, also known as melanoma cell adhesion molecule (MCAM or Mel-CAM), MUC18, S-Endo1, and A32 antigen, is an integral membrane glycoprotein that belongs to the Ig superfamily. CD146 is strongly expressed by murine vascular endothelial cells. It is expressed on about 30% of neutrophils and 60% of NK cells. Unlike in humans, CD146 is undetectable on monocytes, dendritic cells, T cells, NKT cells, B cells, or smooth muscle cells in mouse. It has been reported that an increase in CD146 expression is associated with NK cell maturation. Combined with using CD27 and CD11b staining, CD146 may be an alternative marker to detect final stages of NK cell maturation and define NK cell subsets. CD146+ NK cells were found to be less cytotoxic and to pro |
| G0657 |
AF647 Anti-Mouse CD150/SLAM (TC15-12F12.2) mAb |
CD150 is a 75-95 kD member of the immunoglobulin superfamily, also known as SLAM (signaling lymphocyte activation molecule) or IPO-3. CD150, a single chain type I transmembrane molecule, is expressed on thymocytes, T cell subsets, B cells, dendritic cells, and endothelial cells. The expression is upregulated upon activation. CD150 expression has been shown to be maintained on Th1 but not Th2 clones. T regulatory cells express a relatively high level of CD150. Antibodies against CD150 have been shown to augment IFN-γ production by Th1 cells, especially when co-stimulated through the TCR. CD150 associates with the src homology 2-domain-containing protein tyrosine phosphatase SHP-2, and this association is thought to be involved in signal tran |
| G4392 |
AF647 Anti-Mouse CD19 (1D3) mAb |
CD19, a B lymphocyte-lineage differentiation antigen and a 95-kDa transmembrane glycoprotein, is a member of the immunoglobulin superfamily and is expressed throughout B-lymphocyte development from the pro-B cell stage through mature B cells. Terminally differentiated plasma cells do not express CD19. On mature B cells, CD19 associates with CD21 (CR-2) and CD81 (TAPA-1), forming a multimolecular complex that synergizes with surface immunoglobulin to promote cellular activation. Studies in CD19-deficient mice suggest that the level of CD19 expression influences the generation and maturation of B cells in both bone marrow and peripheral tissues. B-1 lineage B cells, also called CD5+ B cells, are drastically reduced or absent in CD19-deficient |
| G1557 |
AF647 Anti-Mouse CD205/DEC-205 (NLDC-145) mAb |
CD205, also known as DEC-205, is a 205 kD integral membrane protein homologous to the macrophage mannose receptor. It is a type I cell surface protein that belong to the C-type lectin family. CD205 is expressed at high levels by dendritic cells and thymic epithelial cells. It is also expressed by a number of other cell types, such as B lymphocytes, macrophages, Langerhans cells, bone marrow stromal cells, granulocytes, epithelial cells of pulmonary airways, and the capillaries of the brain. CD205 is a novel endocytic receptor used by dendritic cells and thymic epithelial cells to direct captured antigens from the extracellular space to specialized antigen processing. It mediates antigen uptake and presentation and cross-presentation to |
| G4077 |
AF647 Anti-Mouse CD206/MMR (C068C2) mAb |
CD206, also known as mannose receptor (MR), is a 175 kD type I membrane protein. It is a pattern recognition receptor (PRR) belonging to the C-type lectin superfamily. MR is expressed on macrophages, dendritic cells, Langerhans cells, and hepatic or lymphatic endothelial cells. MR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine through its C-type lectin-like carbohydrate recognition domains, sulfated carbohydrate antigens through its cysteine-rich domain, and collagens through its fibronectin type II domain. MR mediates endocytosis and phagocytosis as well as activation of macrophages and antigen presentation. It plays an important role in host defense and provides a link between innate and ada |
| G4647 |
AF647 Anti-Mouse CD3 (17A2) mAb |
CD3ε is one of five polypeptide chains that combine to form the TCR complex. CD3ε is expressed on T lymphocytes, NK-T cels, and to varying degrees on developing thymocytes. CD3 plays roles in TCR signaling, T lymphocyte activation, and antigen recognition. |
| G1257 |
AF647 Anti-Mouse CD357/GITR (DTA-1) mAb |
CD357, also known as GITR (Glucocorticoid-induced Tumor Necrosis Factor Receptor family-Related), is a 66-70 kDa homodimer glycoprotein that belongs to the TNF receptor superfamily. It is also referred to as TNFRSF18. GITR expression was first identified in T lymphocytes treated with dexamethasone, a glucocorticoid. In normal naive mice, GITR is expressed at moderate levels on CD25-positive/CD4-positive/CD8a-negative thymocytes and on CD25-positive/CD4-positive/CD45RB-low splenocytes. It is also expressed at low levels on splenic CD25-negative/CD4-positive/CD45RB-low T lymphocytes, B lymphocytes, macrophages, and dendritic cells. GITR expression is upregulated upon activation of T and B lymphocytes. As a costimulatory receptor, GITR plays a |
| G0852 |
AF647 Anti-Mouse CD38 (90) mAb |
CD38 is a 45 kD type II transmembrane glycoprotein also known as T10. It is an ADP-ribosyl hydrolase expressed at variable levels on hematopoietic cells and in some non-hematopoietic tissues (such as brain, muscle, and kidney). In humans, it is expressed at high levels on plasma cells and activated T and B cells, natural killer (NK) lymphocytes, myeloblasts, and erythroblasts. By functioning as both a cyclase and a hydrolase, CD38 mediates lymphocyte activation, adhesion, and the metabolism of cADPR and NAADP. CD31 is the ligand of CD38. |
| G4152 |
AF647 Anti-Mouse CD4 (GK1.5) mAb |
The CD4 antigen is a 55 kDa cell surface type I membrane glycoprotein belonging to the immunoglobulin superfamily. CD4 acts as a co-receptor which, in cooperation with the T cell receptor (TCR), interacts with class II MHC molecules displayed by antigen-presenting cells (APC). CD4 is expressed by the majority of thymocytes, most helper T cells, a subset of NK-T cells, and weakly by dendritic cells and macrophages. CD4 plays an important role in the development of T cells and is required for mature T cells to function optimally. |
| G0867 |
AF647 Anti-Mouse CD41 (MWReg30) mAb |
CD41 is a transmembrane glycoprotein that is encoded by Itga2b. CD41 associates with Integrin β3 chain (gpIIIa or CD61) to form the gpIIb/IIIa (CD41/CD61) complex. CD41/CD61 is expressed on platelets, megakaryocytes, and early hematopoietic progenitors. The integrin complex binds to fibrinogen, fibronectin, vitronectin, von Willebrand factor, and thrombospondin. It is important for platelet adhesion and aggregation, and it may play a role in osteolytic tumor metastasis. |
| G1047 |
AF647 Anti-Mouse CD43 Activation-Associated Glycoform (1B11) mAb |
CD43, also known as Ly-48, Leukosialin, Sialophorin, Leukocyte Sialoglycoprotein, and gp115, is a large single chain of type I transmembrane glycoprotein with abundant O-glycosylation and sialylation sites. Due to variable glycosylation and sialylation, two isoforms of CD43 have been identified. The 115 kD glycoform of CD43 is expressed on most hematopietic cells including T lymphocytes, NK cells, monocytes, granulocytes, platelets, and CD5+ B cells. It is not present on resting B cells and erythrocytes. While the 130 kD glycoform is thought to be activation-associated form primarily expressed on myeloid cells, pre-B cells, and activated T cells. It has been reported that CD43 binds to CD54 and Siglec-1. CD43 plays dual roles in cell adhesi |
| G0537 |
AF647 Anti-Mouse CD49b (DX5) mAb |
CD49b is a 150 kDa transmembrane glycoprotein that non-covalently associates with CD29 (integrin β1) to form the integrin α2β1 complex known as VLA-2. The rat anti-mouse CD49b antibody has been reported to identify the majority of NK cells and a small T-cell subpopulation in most mouse strains (e.g., A/J, AKR, BALB/c, C3H/HeJ, C57BL/6, C57BL/10, C57BR, C58, CBA/Ca, DBA/1, DBA/2, SJL, SWR, 129/J, but not NOD). The DX5 antibody also recognizes platelets that express high levels of CD49b. |
| G0552 |
AF647 Anti-Mouse CD49b (HMα2) mAb |
CD49b is a 150 kD glycoprotein, also known as α2 integrin, VLA-2 α chain, Integrin α2 chain, and HMα2. It is a member of the integrin family, expressed on NK cells, a subset of splenic CD4+ T cells, NK-T cells, intestinal intraepithelial and lamina propria lymphocytes, epithelial cells, and platelets. By associating with CD29 (integrin β1 subunit), CD49b forms the VLA-2 (integrin α2β1 ) complex. It plays a critical role in both adhesion and lymphocyte activation. The primary ligands for CD49b are collagen, laminin, and fibronectin. |
| G1122 |
AF647 Anti-Mouse CD54 (YN1/1.7.4) mAb |
CD54 is a 90 kD immunoglobulin superfamily member also known as ICAM-1 and Ly-47. It is expressed on activated endothelial cells, high endothelial venules (HEV), T and B cells, monocytes/ macrophages, granulocytes, and dendritic cells. CD54 is an important intracellular adhesion molecule that participates in T cell-T cell, T cell-B cell, and T cell-target cell interactions via binding of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). CD54 has also been shown to be involved in lymphocyte trafficking, making it an important molecule in many immune reactions and inflammation. CD54 is also a receptor for rhinovirus. Antibodies against CD54 can block its interaction with LFA-1 and Mac-1, thereby inhibiting cell-cell adhesion, impairing antigen prese |
| G2952 |
AF647 Anti-Mouse CD64 (X54-5/7.1) mAb |
CD64 is a 72 kD single chain type I glycoprotein also known as FcγRI and FcRI. CD64 is a member of the immunoglobulin superfamily and is expressed on monocytes/macrophages, dendritic cells, and mast cells. The expression can be upregulated by IFN-γ stimulation. CD64 binds IgG immune complex. It plays a role in antigen capture, phagocytosis of IgG/antigen complexes, and antibody-dependent cellular cytotoxicity (ADCC). |
| G4422 |
AF647 Anti-Mouse CD86 (GL1) mAb |
CD86, along with CD80, is a member of the B7 family of costimulatory molecules and plays a crucial role in T cell activation and immune response regulation. CD86 is expressed at low levels on B cells, macrophages, and dendritic cells, and its expression is upregulated on B cells through various stimuli, including the BCR complex, CD40, and certain cytokine receptors. As a type I membrane protein and member of the immunoglobulin superfamily, CD86 serves as a ligand for the T cell surface proteins CD28 and CTLA-4 (CD152). The interaction between CD86 and CD28 provides a costimulatory signal essential for T cell activation during antigen presentation, while binding with CTLA-4 negatively regulates T cell activation, diminishing the immune resp |
| G1062 |
AF647 Anti-Mouse CX3CR1 (SA011F11) mAb |
CX3CR1 is a 40 kD, G-protein coupled receptor, with seven transmembrane regions. CX3CR1 is expressed by resident and alternatively activated macrophages (M2), a subset of monocytes, dendritic cells (DCs), NK cells, a subset of memory T cells, and mast cells. CX3CR1 is involved in cell recruitment during inflammation and participates in cell adhesion and extravasation from blood vessels. Its ligand is CX3CL1, also known as fractalkine or neurotactin. CX3CR1 is also a coreceptor for HIV1 and variations in this gene leads to increased susceptibility to HIV. In the brain, it is expressed by glial cells, which interact with CX3CL1 expressed by neurons. |
| G1812 |
AF647 Anti-Mouse H-2Kb (AF6-88.5) mAb |
H-2Kb is a mouse MHC class I alloantigen expressed on all nucleated cells of mice with the H-2^b haplotype. It plays a key role in presenting endogenous peptides to CD8+ T cells, enabling immune surveillance and cytotoxic T cell responses. |
| G0792 |
AF647 Anti-Mouse IL-10 (JES5-16E3) mAb |
IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. D |
| G4227 |
AF647 Anti-Mouse IL-4 (11B11) mAb |
IL-4 (interleukin-4) is a multifunctional 14 kDa cytokine. IL-4 is mainly produced by activated Th2 and NK cells, with smaller contributions from mast cells and basophils. It signals via the IL-4Rα receptor. Once bound to its receptor, IL-4 promotes the proliferation of activated B and T cells and drives B cell differentiation into plasma cells. It also facilitates class switching to IgE in B cells and enhances MHC class II expression, while suppressing Th1 cell development, macrophage activity, IFNγ production, and IL-12 release by dendritic cells. IL-4, like other cytokines associated with Th2 responses, contributes to airway inflammation commonly seen in allergic asthma. |
| G4317 |
AF647 Anti-Mouse LFA-1α/CD11a (M17/4) mAb |
LFA-1α (lymphocyte function-associated antigen 1 alpha), also known as integrin alpha L chain and CD11a, pairs with CD18 to form LFA-1, a 180 kDa integrin glycoprotein belonging to the integrin family. LFA-1 is expressed on the surface of all leukocytes, including lymphocytes, monocytes, macrophages, and granulocytes. It plays a central role in leukocyte intercellular adhesion through interactions with its ligands ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50), and also contributes to lymphocyte costimulatory signaling. |
| G4437 |
AF647 Anti-Mouse Ly6G (1A8) mAb |
Lymphocyte antigen 6 complex, locus G (Ly-6G), is a 21–25 kDa GPI-anchored protein expressed primarily on peripheral granulocytes and highly specific for neutrophils. Ly-6G serves as a robust marker for neutrophil identification and depletion in mice. Ly-6G modulates neutrophil migration and recruitment to sites of inflammation via interaction with β2 integrins. Its downregulation is associated with age-related functional decline in neutrophils. |
| G4257 |
AF647 Anti-Mouse NK1.1 (PK136) mAb |
NK1.1, also known as CD161b/CD161c, KLRB1, NKR-P1A, and Ly-55, is a type II integral membrane glycoprotein with a C-type lectin domain and is encoded by the Klrb1c/NKR-P1C gene. NK1.1 plays roles in NK cell activation and differentiation, IFN-γ production, cytotoxic granule release, and is thought to be involved in the generation of Th2 cells. NK1.1 is predominantly expressed as a disulfide-linked homodimer on NK cells; however, it is also expressed on NK-T cells, a rare population of T lymphocytes. NK1.1 is only expressed by C57BL/6, FVB/N, and NZB strains of mice and not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129 strains. |
| G2562 |
AF647 Anti-Mouse Siglec H (551) mAb |
The Siglec-H is a member of CD33-related Siglec family which mostly expressed in the innate immune system. Siglec-H is reported to be specifically expressed on plasmacytoid dendritic cells. Siglec-H depends on adaptor protein DAP 12 (DNAX-activating protein of 12 kD) for surface expression and signal transduction. Cross-linking with this antibody can selectively inhibit interferon-alpha production by IPCs following TLR9 ligation. |
| G0477 |
AF647 Anti-Mouse Siglec-F (E50-2440) mAb |
Siglecs are the sialic acid-binding immunoglobulin superfamily lectins defined in the human, each of which has a distinctive expression pattern in the hematopoietic system and at least some of which are known to mediate cell-cell interactions. Orthologous proteins of human Siglec-1 (Sialoadhesin or CD169), Siglec-2 (CD22), and Siglec-4 (myelin-associated glycoprotein) have been characterized in the mouse. Human Siglec-3 (CD33) and Siglecs-5 through -10 are encoded by a cluster of closely related genes, and each has two cytoplasmic ITIM (Immunoreceptor Tyrosine-based Inhibitory Motifs). Similarly, mouse Siglec-F is encoded by the Siglecf gene in a syntenic cluster in the mouse, and the protein has sialic acid-binding activity and an intracyt |
| G1677 |
AF647 Anti-Mouse TCR Vα2 (B20.1) mAb |
TCR Vα2 is a distinct T-cell receptor (TCR) subfamily found in mice with the a, b, and c haplotypes. The TCR α chain complexes with the TCR β chain in 95% of T cells, forming the T cell receptor (α/β TCR), while the remaining 5% of T cells express gamma (γ) and delta (δ) chains (γ/δ TCR). TCR Vα2 represents a specific variant of the TCR α chain that plays a role in antigen recognition and is useful in the study of T-cell function and immune responses in mice with these specific haplotypes. |
| G4362 |
AF647 Anti-Mouse Ter-119 (TER-119) mAb |
TER-119 is a lineage marker for erythroid cells from early proerythroblast to mature erythrocyte stages in adult blood, spleen, and bone marrow. It is also present in yolk sac, and fetal and newborn liver. The TER-119 antigen is not expressed by cells of earlier erythroid development at BFU-e (blast-forming unit erythroid) stage or CFU-e (colony-forming unit erythroid) stage. |
| G2037 |
AF647 Anti-Mouse/rat CD81 (Eat-2) mAb |
CD81 is a 26 kD non-glycosylated member of the tetraspanin superfamily (TM4SF), also known as TAPA-1. CD81 is expressed on T and B cells, NK cells, dendritic cells, thymocytes, endothelial cells, and fibroblasts. CD81 induces B cell adhesion via the VLA-4 integrin and has been shown to play a role in early T cell development. CD81 associates with several other cell-surface proteins in a multimolecular complex, including CD19, CD21, CD20, CD37, CD53, and CD82 in B cells, and CD4, CD8 and CD82 in T cells. |
| H4227 |
AF647 Anti-Neuron-specific beta-III Tubulin (TuJ-1) mAb |
β-III Tubulin, also known as tubulin β-4, is regarded as a neuron-specific marker. The expression of β-III Tubulin has been suggested to be one of the earliest markers to signal commitment in primitive neuroepithelium. |
| G0627 |
AF647 Anti-T-bet(B2D24) mAb |
T-bet, also known as TBX21, is a T-cell specific transcription factor containing a single T-box DNA-binding domain. It controls the expression of the TH1 cytokine, interferon-gamma. Both Th1 and Th17 cells are crucial in immune regulation and autoimmune disease development. T-bet initiates Th1 lineage development from naive Th precursor cells and directs T cell differentiation to Th1 versus Th17. T-bet is cooperating with Stat4 (signal tranducer and activator of transcription 4) in programming chromatin architecture for Th1 gene expression. Genetic variations in T-bet are associated with susceptibility to aspirin-induced asthma and nasal polyps. |
| G4032 |
AF647 Anti-TCF1/TCF7 (E19C1) mAb |
LEF1 and TCF are members of the high mobility group (HMG) DNA-binding protein family of transcription factors that consists of the following: Lymphoid Enhancer Factor 1 (LEF1), T Cell Factor 1 (TCF1/TCF7), TCF3/TCF7L1, and TCF4/TCF7L2. LEF1 and TCF1/TCF7 were originally identified as important factors that regulate early lymphoid development and act downstream in Wnt signaling. LEF1 and TCF bind to Wnt response elements to provide docking sites for β-catenin, which translocates to the nucleus to promote the transcription of target genes upon activation of Wnt signaling. LEF1 and TCF are dynamically expressed during development and aberrant activation of the Wnt signaling pathway is involved in many types of cancers, including colon cancer. |
| G0927 |
AF647 Anti-TCR gammadelta(J18P6) mAb |
TCR gamma/delta (T-cell receptor gamma/delta) are specialized T-cells in the immune system. The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflamm |
| G0297 |
AF647 Anti-TCR-β (H57-597) mAb |
The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system c |
| G3432 |
AF647 Anti-TLR4/MD-2 Complex (MTS510) mAb |
MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e.g., human MD-2 transfected into mouse cells can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4. |
| H2352 |
AF647 Anti-TLR9 (26C593.2) mAb |
Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. TLR9 forms a subfamily along with TLR7 and TLR8 that recognize viral RNA and CpG DNA sequences and are localized in intracellular acidic compartments such as the phagolysosome. Unlike other TLRs which act through adaptor molecules such as TOLLIP, TIRAP, TRIF, and MyD88 to activate various kinases and transcription factors to respond to potential infection, TLR9 is strictly dependent on MyD88. |
| G4197 |
AF647 Mouse IgG1 isotype control (MOPC-21) |
Mouse IgG1 isotype control is a mouse myeloma protein. It was selected as an isotype control following screening for low background on a variety of mouse and human tissues. |
| G0642 |
AF647 Rat IgG2a kappa Isotype Control (eBR2a) |
Rat IgG2a is an immunoglobulin subclass that is commonly used in research and diagnostic applications. It is produced by the rat immune system and is known for its ability to activate complement and mediate antibody-dependent cell-mediated cytotoxicity (ADCC). Rat IgG2a has a molecular weight of approximately 160 kDa and is composed of two heavy chains and two light chains. It is often used as a control or reference antibody in experiments involving rat models, and is also commonly used in flow cytometry and immunohistochemistry applications.
|
| G0802 |
AF700 Anti-CD103/Integrin αE (2E7) mAb |
CD103, also known as ITGAE or Integrin alpha E, is a molecule that non-covalently associates with integrin beta 7 to form a heterodimeric integral membrane protein. This protein is part of the integrin family, characterized by an alpha chain and a beta chain. Specifically, CD103 includes a 150 kDa alpha chain and a 120 kDa beta chain, with the alpha integrin undergoing post-translational cleavage in the extracellular domain to yield disulfide-linked heavy and light chains. CD103 is primarily expressed on mucosa-associated T lymphocytes, intraepithelial lymphocytes (IELs), and activated cells, as well as a subset of TGF beta-1 cells. It is preferentially found in human intestinal IELs, where it plays a role in adhesion and may serve as an ac |
| G4057 |
AF700 Anti-CD117/c-Kit (2B8) mAb |
KIT (c-KIT), also known as CD117, is a proto-oncogene and a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). KIT was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT together with its ligand regulates growth and activation of a variety of hemopoietic and non-hemopoietic cells. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Recently, deregulation of the KIT receptor TK by the prevalent activation loop mutation D816V has served as a focal point in therapeutic strategies aimed at curbing neoplastic mast cell growth. c-Kit is expressed in hematopoietic stem cells, germ cell |
| G2077 |
AF700 Anti-CD11b+CD11c (OX42) mAb |
CD11b (Integrin αM) and CD11c (Integrin αX) are α-chain integrins that belong to the β2 integrin family. They are primarily expressed on myeloid cells, including monocytes, macrophages, dendritic cells, and neutrophils. These integrins play key roles in cell adhesion, migration, phagocytosis, and immune regulation through interactions with ligands such as iC3b, ICAM-1, and fibrinogen. CD11b is highly expressed on monocytes and neutrophils, whereas CD11c is widely used as a marker for dendritic cells. |
| G0097 |
AF700 Anti-CD11c (N418) mAb |
CD11, along with CD18, form a heterodimer adhesion molecule. In particular, CD11 is composed of CD11a, CD11b and CD11c. CD11a is a leukocyte marker that is expressed in B and T lymphocytes, macrophages, monocytes, neutrophils, basophils and eosinophils. CD11b is primarily expressed by monocytes, macrophages, natural killer cells, some B and T-cells, and granulocytes. CD11c is expressed in monocytes, macrophages, natural killer cells, some granulocytes and less so in a subset of lymphocytes. |
| G0457 |
AF700 Anti-CD127 (A7R34) mAb |
CD127, also known as the Interleukin-7 receptor alpha chain (IL-7Ralpha), is a type I glycoprotein with a molecular weight of 75-80 kDa. It forms a multi-functional receptor complex with CD132, the common gamma chain, to create the IL-7 receptor (IL-7R), which is crucial for lymphopoiesis. The active IL-7 receptor is an alpha/gamma chain heterodimer, where the gamma chain also associates with the interleukin-2 receptor and primarily activates signal transduction, while the alpha chain determines specific signaling events through its association with cytoplasmic signaling molecules. CD127 is expressed by immature B cells through the early pre-B stage, thymocytes during various stages of development, and most mature T cells, with transient do |
| H0337 |
AF700 Anti-CD161 (HP-3G10) mAb |
CD161, also known as NKR-P1A, is a type II transmembrane lectin-like receptor and member of the killer cell lectin-like receptor (KLR) family. CD161 exists as a homodimer and is prominently expressed on natural killer (NK) and NKT cells, where it is proposed to regulate the function of both cell types. CD161 is also found on T cell subsets, including T regulatory cells (Tregs), memory/effector CD4+ T cells, and CD8+ T cells. Th17 cells have been demonstrated to co-express CD161, as surface IL-17A+ cells are contained within the CD161+ fraction of CD4 T cells, so that CD161 (in combination with CCR6) is often used as a marker for enrichment of Th17 cells. |
| H1297 |
AF700 Anti-CD18 (YFC118.3) mAb |
CD18 is an integral membrane glycoprotein of ~95 kDa, also known as the beta 2 chain of the LFA-1 complex. CD18 non-covalently links to CD11a, b, or c molecules to form the heteromeric LFA-1 complex. CD18 acts as the receptor for ICAM-1 and is important for cell adhesion and cell-cell interactions. |
| G4132 |
AF700 Anti-CD23 (B3B4) mAb |
CD23 is a 45 kDa glycoprotein that serves as a low-affinity receptor for IgE, playing a crucial role in regulating IgE responses and B cell activation. It is expressed on mature B cells, mantle zone B cells, follicular dendritic cells, and at lower levels on T cells, NK cells, Langerhans cells, and platelets. CD23 expression is upregulated upon B cell activation, and its soluble forms are biologically active, acting as potent mitogenic factors. CD23 is strongly expressed on Epstein-Barr virus (EBV)-transformed B lymphoblasts and is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells. It is also detected in neoplastic cells from cases of B cell chronic lymphocytic leukemia and some centroblastic/centrocytic lym |
| G0277 |
AF700 Anti-CD24 (M1/69) mAb |
CD24 is a 35-50 kDa glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed on a variety of cell types, including erythrocytes, thymocytes, peripheral lymphocytes, and cells of the myeloid lineage. It is variably glycosylated, resulting in heterogeneity in molecular mass across different cell lineages, which can affect antibody staining levels on lymphocyte populations. In the context of B-cell development, CD24 is expressed from the pro-B-cell stage in the bone marrow through to mature, surface Ig-positive B cells, with very low or negative expression on plasma cells. It is also present on the majority of B-lineage acute lymphoblastic leukemias, B-cell chronic lymphocytic leukemias (CCLs), and B-cell non-Hodgkin's lymphomas. CD2 |
| H0172 |
AF700 Anti-CD27 (O323) mAb |
CD27 (TNFRSF7) is a cell surface homodimer of ≥55 kDa subunits that provides co-stimulatory signaling in support of T cell (TCR) and B cell (BCR) receptors. Compared to CD28, whose TCR co-stimulatory signal can trigger cell proliferation, CD27 signaling promotes cell survival and differentiation to effector/memory stages. CD27 may be shed following interaction with its ligand CD70, which is typically expressed on activated dendritic cells, T cells, and B cells. In B cells, CD27 is a phenotypic marker for memory B cells and has also been included among markers for identifying B regulatory cells (Bregs), which regulate CD4+ T cell proliferation and Foxp3/CTLA-4 expression in Treg cells. |
| G1102 |
AF700 Anti-CD278 (C398.4A) mAb |
ICOS, also known as inducible costimulatory molecule and H4, is a 47-57 kD protein. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes. It is able to costimulate T cells proliferation. In addition, ICOS is involved in humoral immune responses (B cell germinal center formation). The ICOS ligand is B7h/B7RP-1 or B7-H2. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development. |
| H0697 |
AF700 Anti-CD284/TLR4 (HTA125) mAb |
TLR4 is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This receptor is most abundantly expressed in placenta, and in the myelomonocytic subpopulation of leukocytes. Mammalian cells respond to LPS by activating TLR4. TLR4 belongs to the multi-protein complex of the lipopolysaccharide (LPS) receptor, containing CD14, LY96, and TLR4, and is involved in signal transduction events induced by LPS found in most gram-negative bacteria. TLR4 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents and |
| G0202 |
AF700 Anti-CD31/PECAM-1 (390) mAb |
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulatio |
| G4102 |
AF700 Anti-CD326/EpCAM (G8.8) mAb |
Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA), also known as CD326, is a transmembrane glycoprotein expressed in the epithelium with a molecular weight of approximately 40 kDa, which functions as an epithelial cell adhesion molecule. Ep-CAM functions as a homotypic calcium-independent cell adhesion molecule, and has a direct impact on cell cycle, proliferation and metabolism of epithelial cells and fibroblasts due to its ability to rapidly induce the proto-oncogene c-myc and the cell cycle regulating genes cyclin A and E. Ep-CAM mediates Ca2+-independent homotypic interactions. Formation of Ep-CAM-mediated adhesions have a negative regulatory effect on adhesions mediated by classic cadherins, which may have strong |
| G0127 |
AF700 Anti-CD34 (RAM34) mAb |
CD34 is a highly glycosylated monomeric with a molecular weight range of 111-115 kDa surface protein that is present on many stem cell populations. CD34 is a stem cell marker although its expression on human hematopoietic stem cells is reversible. CD34 may serve as a surface receptor that undergoes receptor-mediated endocytosis and regulates adhesion, differentiation and proliferation of hematopoietic stem cells and other progenitors. CD34 expression is likely to represent a specific state of hematopoietic development that may have altered adhering properties with expanding and differentiating capabilities in both in vitro and in vivo conditions. CD34 is possibly an adhesion molecule with a putative role for mediating the attachment of stem |
| G0082 |
AF700 Anti-CD44 (IM7) mAb |
CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential. CD44 is expressed by hematopoietic, non-hematopoietic cells, epithelial tissu |
| G0022 |
AF700 Anti-CD45 (30-F11) mAb |
CD45, also known as Leukocyte Common Antigen (LCA). CD45 is expressed by all hematopoietic cells excluding mature erythrocytes and platelets. The cytoplasmic portion of CD45 has tyrosine phosphatase enzymatic activity and plays an important role in activation of lymphocytes.
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| G0352 |
AF700 Anti-CD45.1 (A20) mAb |
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides t |
| G0112 |
AF700 Anti-CD45R/B220 (RA3-6B2) mAb |
CD45R (PTPRC) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. CD45 contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. CD45 is specifically expressed in hematopoietic cells and has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists in multiple isoforms as a result of alternative splicing, and these isoforms di |
| G3487 |
AF700 Anti-CD5 (53-7.3) mAb |
CD5 is a 67 kDa human T-lymphocyte single-chain transmembrane glycoprotein. CD5 is present on all mature T-lymphocytes, on most of thymocytes and on many T-cell leukemias and lymphomas. CD5 also reacts with a subpopulation of activated B-cells and may act as a receptor in regulating T-cell proliferation. CD5 is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. CD5 is expressed by many T cell leukemia, lymphomas, and activated T cells. Diseases associated with CD5 dysfunction include thymus cancer and Richter's Syndrome. |
| G0247 |
AF700 Anti-CD62L/L-Selectin (MEL-14) mAb |
The human CD62L is a 74-95 kDa glycoprotein member of the selectin family of adhesion receptors. L-Selectin is comprised of an aminoterminal C-type lectin binding domain, an epidermal growth factor-like domain, two short consensus repeat (SCR) sequences homologous to those found in complement binding proteins, a short spacer region, a transmembrane region and a short cytoplasmic region. Human CD62L (L-Selectin) is constitutively expressed on all classes of leukocytes including lymphocytes (except a substantial population of memory T cells), monocytes and polymorphonuclear cells. |
| G0487 |
AF700 Anti-CD68 (ED1) mAb |
CD68 antibody recognizes the rat ED1 antigen, a heavily glycosylated protein of ~90 -110 kDa, also known as rat CD68. The ED1 antigen is expressed on most macrophages populations, as well as on monocytes and is considered as a pan-macrophage marker in the rat. ED1 is expressed predominantly on the lysosomal membrane and lightly on the cell surface. The expression of ED1 antigen being predominantly cytoplasmic, flow cytometry results are improved by the use of a membrane permeabilization procedure, such as Leucoperm, prior to staining. |
| G0502 |
AF700 Anti-CD68 (FA-11) mAb |
CD68 is considered a pan-macrophage marker, predominantly expressed on the intracellular lysosomes of tissue macrophages/monocytes, including Kupffer cells, microglia, histiocytes and osteoclasts, and is expressed to a lesser extent by dendritic cells and peripheral blood granulocytes. CD68 is expressed by many tumor types including some B cell lymphomas, blastic NK lymphomas, melanomas, granulocytic (myeloid) sarcomas, hairy cell leukemias, and renal, urinary and pancreatic tumors, and can be used to demonstrate the presence/localization of macrophages. |
| G0007 |
AF700 Anti-CD8a (53-6.7) mAb |
CD8 (Cluster of differentiation 8), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, plays an integral role in signal transduction, and T cell differentiation and activation. CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8alpha and CD8beta, where it functions as a co-receptor, along with T cell receptor (TCR), for major histocompatibilty complex class I (MHC-I) molecules; whereas its counterpart, CD4, acts as a co-receptor for MHC-II molecules. CD8 exists on the cell surface, where the CD8alpha chain is essential for binding to MHC-I. CD8 is also expressed on a subset of T cells, NK cells, monocytes and dendritic cells as disulfide-linked homodimers of CD8alpha. Ligation of MH |
| H0772 |
AF700 Anti-FCER1A (AER-37 (CRA1)) mAb |
Fc epsilon RI alpha, also known as FcεRIα, is a subunit of the high-affinity receptor for IgE, primarily expressed on mast cells and basophils. Its expression is upregulated by the presence of IgE. FcεRIα forms a tetrameric complex with one beta and two gamma subunits, which are essential for signal transduction. The beta and gamma subunits contain immunoreceptor tyrosine-based activation motifs (ITAMs). The FcεRI complex plays a crucial role in triggering IgE-mediated allergic reactions.
When allergen-bound IgE molecules bring together two or more high-affinity IgE receptors, it leads to the release of mediators such as histamine, which are responsible for allergy symptoms.
This process couples allergens and mast cells to initiate inflamma |
| G0757 |
AF700 Anti-FCER1A (MAR-1) mAb |
Fc epsilon RI alpha, also known as FceR1 alpha, is a subunit of the high-affinity receptor for IgE, primarily expressed on mast cells and basophils. Its expression is upregulated by the presence of IgE. Fc epsilon RI alpha forms a tetrameric complex with one beta and two gamma subunits, which are essential for signal transduction. The beta and gamma subunits contain immunoreceptor tyrosine-based activation motifs (ITAMs). The Fc epsilon RI complex plays a crucial role in triggering IgE-mediated allergic reactions. When allergen-bound IgE molecules bring together two or more high-affinity IgE receptors, it leads to the release of mediators such as histamine, which are responsible for allergy symptoms. This process couples allergens and mast |
| H0397 |
AF700 Anti-Granzyme B (GB11) mAb |
Granzyme B is a member of the granzyme serine protease family, and is found in the granules of cytotoxic T cells and NK cells. Granzyme B has been described as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation, and CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells. Granzyme B is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. The receptor involved in this process has been identified as mannose 6-phosphate receptor which functions as a death receptor for Granzyme B during cytotoxic T cell-induced ap |
| H1462 |
AF700 Anti-Human CD10 (HI10a) mAb |
CD10, also known as Neutral Endopeptidase (NEP), Enkephalinase, Atriopeptidase, and Neprilysin, is a 100 kDa type II transmembrane glycoprotein encoded by the MME (membrane metallo-endopeptidase) gene. CD10 has neutral endopeptidase activity and is also referred to as the Common Acute Lymphoblastic Leukemia Antigen (CALLA). It is expressed on a wide variety of normal and neoplastic cell types, including granulocytes, bone marrow stromal cells, a subset of B-cell progenitors, germinal center B cells, and fibroblasts. CD10 is a cell surface metalloendopeptidase that inactivates several signaling molecules, playing a significant regulatory role in the nervous, immune, and other systems. |
| H0832 |
AF700 Anti-Human CD103/Integrin αE (Ber-ACT8) mAb |
CD103 is a type I transmembrane glycoprotein also known as αE integrin, integrin αIEL chain, and human mucosal lymphocyte antigen 1. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. Treg cells express high level of CD103. Hairy cell leukemia has also been shown to express CD103. The expression of CD103 on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as an αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD |
| H0457 |
AF700 Anti-Human CD107a (H4A3) mAb |
CD107a, also known as Lysosomal-associated membrane protein 1 (LAMP-1), is a ~110 kDa type I transmembrane protein that is heavily glycosylated and widely expressed by cells primarily on the luminal surface of their lysosomes. It is also expressed on the surface of activated platelets, activated lymphocytes, cytotoxic T cells and NK cells, and some tumor cell lines, including U937 and KG1a. LAMP-1 can serve as a ligand for E-selectin-mediated cell adhesion. LAMP-1 and LAMP-2 (CD107b) are carriers for poly-N-acetyllactosamines and are able to display sialyl Le[x] termini. |
| H0082 |
AF700 Anti-Human CD11b (CBRM1/5) mAb |
CD11b, a 165-170 kDa type I transmembrane glycoprotein also known as αM integrin, Mac-1, CR3, and C3biR. CD11b non-covalently associates with integrin β2 (CD18) and is expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b/CD18 is critical for the transendothelial migration of monocytes and neutrophils as well as adhesion, phagocytosis, and neutrophil activation. CD11b/CD18 interacts with ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4, CD14, CD23, heparin, iC3b, fibrinogen and factor X. |
| H0067 |
AF700 Anti-Human CD11b (ICRF44) mAb |
CD11b is a 165-170 kD type I transmembrane glycoprotein also known as αM integrin, Mac-1, CR3, and C3biR. CD11b non-covalently associates with integrin β2 (CD18) and is expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b/CD18 is critical for the transendothelial migration of monocytes and neutrophils. It is also involved in granulocyte adhesion, phagocytosis, and neutrophil activation. CD11b/CD18 interacts with ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4, CD14, CD23, heparin, iC3b, fibrinogen, and factor X. |
| H0142 |
AF700 Anti-Human CD11c (3.9) mAb |
CD11c is a 145–150 kDa type I transmembrane glycoprotein also known as integrin αx and CR4. CD11c non-covalently associates with integrin β2 (CD18) and is expressed on monocytes/macrophages, dendritic cells, granulocytes, NK cells, and subsets of T and B cells. CD11c has been reported to play a role in adhesion and CTL killing through its interactions with fibrinogen, CD54, and iC3b. |
| H3802 |
AF700 Anti-Human CD137 (4B4-1) mAb |
CD137 is a 39 kD transmembrane protein also known as 4-1BB. It is expressed on activated T cells. CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily. CD137 appears to be important for T cell proliferation and survival, and induces monocyte activation through its interaction with 4-1BB ligand. |
| H0187 |
AF700 Anti-Human CD14 (M5E2) mAb |
CD14 is a 53–55 kDa glycosylphosphatidylinositol (GPI)-anchored single-chain glycoprotein expressed at high levels on monocytes, macrophages, and neutrophils. CD14 is a multifunctional receptor and is constitutively expressed on the surface of mature monocytes and macrophages. It serves as a high-affinity receptor for lipopolysaccharide (LPS) and binds LPS in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute-phase serum protein. CD14 also exists in a soluble form (sCD14) and is released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. The soluble sCD14 is important for neutralizing allochthonous lipopolysaccharides by reconstituted lipoprotein particles and can discriminate structural dif |
| H1132 |
AF700 Anti-Human CD16 (3G8) mAb |
CD16a is a ~50–65 kDa type I transmembrane glycoprotein encoded by FCGR3A (Fc fragment of IgG receptor IIIa), which belongs to the immunoglobulin superfamily. CD16a is also known as Fc-gamma RIII-alpha (FcγRIIIA or FcRIIIa) and is expressed on natural killer (NK) cells, activated monocytes, macrophages, γδ T cells, immature thymocytes, and mast cells. CD16a binds immune-complexed or aggregated IgG and associates with CD247/TCRζ in NK cells and FcεRIγ chains in phagocytes and mast cells to transduce intracellular signals. CD16a functions in antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses including phagocytosis, cytokine production, or mediator release. CD16b is a ~48 kDa glycophosphatidylinositol (GPI)- |
| H2107 |
AF700 Anti-Human CD172a/b (SE5A5) mAb |
CD172a, also known as signal-regulatory protein α (SIRPα), src homology 2 domain-containing phosphatase substrate-1 (SHPS1), PTPNS1, BIT, MFR, and P84, is a 75-110 kD transmembrane glycoprotein involved in receptor tyrosine kinase coupled signaling pathway. It belongs to the Ig superfamily and is primarily expressed on monocytes/macrophages, granulocytes, dendritic cells, and neurons. CD172a serves as a substrate of activated receptor tyrosine kinases (RTKs). The interaction of CD172a intracellular domain with SHP-1 and SHP-2 displays negative signaling in the regulation of leukocyte adhesion and transmigration, T cell activation, macrophage fusion, and phagocytosis. CD47 (IAP) is the extracellular ligand for CD172a. SIRPα was recently demo |
| H0007 |
AF700 Anti-Human CD19 (HIB19) mAb |
CD19 is a 95 kDa type I transmembrane glycoprotein expressed during all stages of B-cell maturation and differentiation, except on plasma cells. It is also present on follicular dendritic cells but not found on T cells or normal granulocytes. CD19 functions as a signal transduction molecule that regulates B cell development, activation, proliferation, and differentiation. It associates with complement receptor 2 (CD21), TAPA-1 (CD81), Leu 13, and/or MHC class II to form a signal transduction complex on the surface of B cells.
|
| H0022 |
AF700 Anti-Human CD19 (LT19) mAb |
CD19 is a type I transmembrane glycoprotein of 95 kDa that belongs to the immunglobulin superfamily. CD19 is expressed on B cells throughout most stages of B cell differentiation, though its expression is down-regulated during their terminal differentiation to plasma cells. Expression of CD19 is also found in the majority of B cell–derived malignancies. CD19 is further present on follicular dendritic cells. On B cells, CD19 associates with CD21, CD81, and CD225 (Leu-13) forming a signal transduction complex. |
| H1582 |
AF700 Anti-Human CD1a (HI149) mAb |
CD1a is a type I transmembrane glycoprotein. The 49 kDa CD1a polypeptide is associated with β2-microglobulin. CD1a is expressed on cortical thymocytes, dendritic cells and Langerhans cells. CD1a has structural similarities to the MHC class I antigen, and plays a role in antigen presentation. |
| H1597 |
AF700 Anti-Human CD1c (L161) mAb |
CD1c, also known as R7 or M241, is a 43 kD member of the five CD1 antigens (CD1a-e) in humans. The CD1 molecules are type I glycoprotein with structural similarities to MHC class I and are non-covalently associated with β2-microglobulin, belonging to the Ig superfamily. CD1c is expressed on cortical thymocytes, Langerhans cells, dendritic cells, and a subset of B cells. It has been reported that CD1c is also expressed on mature T cells in a tightly regulated manner. CD1c is involved in antigen-presentation of glycolipids. It may also act in T cells as an immune regulatory molecule. |
| H1162 |
AF700 Anti-Human CD20 (2H7) mAb |
CD20 is a 33-37 kD, four transmembrane spanning protein, also known as B1 and Bp35. CD20 is expressed on pre-B-cells, resting and activated B cells (not plasma cells), some follicular dendritic cells, and at low levels on a T cell subset. CD20 is heavily phosphorylated on activated B cells and malignant B cells. Homo-oligomeric complexes of CD20 are thought to form Ca2+ conductive ion channels in the plasma membrane of B cells. The CD20 molecule is involved in B-cell activation and is associated with various Src family kinases (Lyn, Lck, Fyn). It exists in a complex with MHC class I and II, CD53, CD81, and CD82. |
| H4252 |
AF700 Anti-Human CD25 (M-A251) mAb |
The CD25 antigen is also known as the human low-affinity interleukin-2 receptor α chain (IL-2Rα) and the Tac antigen. The CD25antigen is present on a subset of peripheral blood lymphocytes. Antigen density increases on phytohemagglutinin (PHA)-, concanavalin A (Con A)-, and CD3-activated T lymphocytes; T lymphocytes from mixed lymphocyte cultures; and HTLV-infected T-lymphocyte leukemia lines, for example, HUT-102. Recombinant IL-2 blocks the binding of CD25 to PHA-activated T lymphocytes. CD4+/CD25+ regulatory T cells might directly regulate the function of responsive T cells. The CD25antibody is composed of mouse IgG1 heavy chains and kappa light chains |
| H0442 |
AF700 Anti-Human CD279/PD-1 (EH12.2H7) mAb |
Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC) are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion. |
| H4102 |
AF700 Anti-Human CD28 (CD28.2) mAb |
CD28 is a 44 kDa homodimeric transmembrane glycoprotein expressed on most mature T cells, thymocytes, and plasma cells. It acts as a costimulatory receptor, binding to CD80 and CD86 ligands, and plays a crucial role in T cell-B cell interactions. CD28 is believed to initiate and regulate a distinct signal transduction pathway that is separate from those stimulated by the TCR complex. The binding of CD28 to its ligands can also influence immune responses, including the production of IL-2 and changes in intracellular calcium concentrations. |
| H0232 |
AF700 Anti-Human CD31 (WM59) mAb |
CD31 (PECAM-1), also known as GPIIA' or EndoCAM, is a 130 kDa type I transmembrane glycoprotein belonging to the Ig gene superfamily. It is widely expressed on platelets, monocytes, granulocytes, NK cells, T cell subsets, and in high amounts on endothelial cells. CD31 functions as a vascular endothelial cell adhesion molecule, playing a critical role in the transendothelial migration of leukocytes during inflammatory responses. It is also involved in thrombosis, angiogenesis, and wound healing. The antibody against PECAM-1 binds to an epitope near extracellular domain 2 of CD31.
Clone WM59 also cross-reacts with peripheral blood platelets and leukocytes of baboon, and both rhesus and cynomolgus macaque monkeys. The staining intensity of WM5 |
| H1402 |
AF700 Anti-Human CD314/NKG2D (1D11) mAb |
CD314, also known as NKG2D or KLRK1, is a 42 kDa type II transmembrane glycoprotein and a member of the C-type lectin family. It is expressed on human NK cells, as well as on virtually all TCR γ/δ+ and CD8+ TCR α/β+ T cells. NKG2D functions as an activating receptor that binds strongly to several ligands, including MICA, MICB, and ULBP-1, -2, and -3, which are expressed by different target cell types. Unlike other natural cytotoxicity receptors (NCR), NKG2D is not restricted to NK cells. It plays a critical role in natural cytotoxicity, aiding normal NK cells in attacking a variety of tumor or normal target cells. NKG2D can complement the role of NCR in tumor cell lysis, and combined masking of both NCR and NKG2D can lead to a complete inhi |
| H0922 |
AF700 Anti-Human CD33 (WM53) mAb |
CD33, also known as Sialic acid-binding Ig-like lectin 3 (Siglec-3), gp67, or p67, is a 67 kDa type I transmembrane glycoprotein expressed on monocytes, activated T cells, myeloid progenitors, and mast cells. CD33 is absent on normal platelets, lymphocytes, erythrocytes, and hematopoietic stem cells. This glycoprotein can reportedly function as a sialic acid-dependent cell adhesion molecule. This function can be modulated by endogenous sialoglycoconjugates when CD33 is expressed on the membrane. |
| H3652 |
AF700 Anti-Human CD366 (F38-2E2) mAb |
CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells). Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance. |
| H0052 |
AF700 Anti-Human CD4 (L200) mAb |
CD4 is a 56 kDa transmembrane glycoprotein expressed on the T-helper/inducer subset of peripheral blood lymphocytes in humans. It is primarily found on CD3-positive, CD8-negative T cells and does not react with B- or NK-cell markers. In baboons, CD4 is expressed on lymphocytes and weakly on monocytes. The distribution of CD4 on lymphocytes is similar between humans and these non-human primates. |
| H0037 |
AF700 Anti-Human CD4 (RPA-T4) mAb |
CD4 is a 56 kDa transmembrane glycoprotein expressed on the T-helper/inducer subset of normal human peripheral blood lymphocytes. The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex |
| H0562 |
AF700 Anti-Human CD40 (5C3) mAb |
CD40 is a 45–48 kDa type I transmembrane glycoprotein primarily expressed on B lymphocytes, though it is absent on terminally differentiated B cells. It is also found on endothelial cells, basal epithelial cells, certain epithelial cell carcinomas, follicular dendritic cells, macrophages, fibroblasts, keratinocytes, and CD34+ hematopoietic progenitor cells. CD40 plays a critical role in B-cell growth, proliferation, and differentiation, including immunoglobulin isotype switching. Engagement of CD40, particularly in the presence of IL-4 or costimulation with anti-µ or anti-CD20 antibodies, can promote B-cell proliferation.
|
| H0892 |
AF700 Anti-Human CD41a (HIP8) mAb |
CD41a, also known as Integrin αIIb or Platelet GPIIb, forms a calcium-dependent complex with CD61 (β3 integrin or GPIIIa) that is normally expressed on platelets and megakaryocytes. The CD41/CD61 complex serves as a receptor for fibrinogen, fibronectin, and von Willebrand factor, mediating platelet adhesion and aggregation. Blocking CD41 can completely inhibit ADP-, epinephrine-, and collagen-induced platelet activation, and partially inhibit ristocetin- and thrombin-induced activation. |
| H4042 |
AF700 Anti-Human CD42b (HIP1) mAb |
CD42b is also known as the Platelet glycoprotein Ib alpha chain that is encoded by the GP1BA gene. CD42b is disulfide bonded to CD42c to form a 170 kDa heterodimer, GPIb. GPIb forms a noncovalent complex with CD42a and CD42d (CD42 complex) that is expressed on platelets and megakaryocytes. The CD42 complex serves as the von Willebrand Factor (vWF) surface receptor involved in the adhesion of platelets to the subendothelium of damaged vascular walls. This antibody inhibits the ristocetin-dependent binding of vWF to platelets and partially inhibits collagen-induced aggregation. |
| H0097 |
AF700 Anti-Human CD45 (HI30) mAb |
CD45 is encoded by the PTPRC (Protein tyrosine phosphatase receptor type C) gene. CD45, also known as the leukocyte common antigen (LCA), is a member of the protein tyrosine phosphatase (PTP) family. It is present on all human leukocytes including lymphocytes, monocytes, granulocytes, eosinophils, and thymocytes. CD45 is absent from circulating erythrocytes, platelets, or mature erythroid cells of bone marrow and non-hemopoietic tissues. |
| H0742 |
AF700 Anti-Human CD45RA (HI100) mAb |
CD45RA, a 220 kDa isoform of the human leukocyte common antigen, is expressed on approximately 40–50% of peripheral CD4+ T cells, 50% of peripheral CD8+ T cells, and on a portion of B cells and monocytes. The CD45RA antigen is expressed by naïve and activated T cells. CD45RA-specific antibodies are useful for the study of the suppressor/inducer subpopulation of CD4+ lymphocytes. |
| H3982 |
AF700 Anti-Human CD5 (UCHT2) mAb |
CD5, also known as Leu-1, Ly-1 and T1, is a 67 kD single chain type I glycoprotein that is a member of the scavenger receptor superfamily. CD5 is expressed on T cells, thymocytes, B cell subsets, chronic B lymphocytic leukemia (B-CLL), and peripheral blood dendritic cells. CD5 modulates T and B cell receptor signaling, thymocyte maturation, and T-B cell interactions. One of its ligands is CD72. |
| H1252 |
AF700 Anti-Human CD54 (HA58) mAb |
CD54, also known as Intercellular Adhesion Molecule 1 (ICAM-1), is an 85-110 kDa type I transmembrane glycoprotein that belongs to the immunoglobulin supergene family. A soluble form of CD54 can also be found in biological fluids. CD54 is expressed on endothelial cells, as well as on both resting (weak) and activated (moderate) lymphocytes and monocytes. It serves as a ligand for LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). The CD54 adhesion molecule plays a key role in inflammatory and immune responses, as well as in neoplasia. |
| H0292 |
AF700 Anti-Human CD62L (DREG-56) mAb |
CD62L (L-selectin) is a cell surface glycoprotein expressed on neutrophils, monocytes, T- and B-lymphocyte subsets, and NK cells. CD62L functions as a lymphocyte homing receptor, playing a key role in the migration of lymphocytes to peripheral lymph nodes via high endothelial venules (HEV). |
| H1327 |
AF700 Anti-Human CD63 (H5C6) mAb |
CD63 is a 53 kDa, type III lysosomal glycoprotein that belongs to the tetraspan transmembrane 4 superfamily (TM4SF). It is expressed on activated platelets, monocytes, and macrophages, and is also known by several other names, including LIMP, gp55, melanoma-associated antigen ME491, Pltgp40, and LAMP-3. CD63 is widely expressed on the surface and in the cytoplasm of various hematopoietic cells (such as monocytes and macrophages) as well as non-hematopoietic cells (including endothelium, fibroblasts, osteoclasts, and smooth muscle cells). It plays a key role in mediating cellular adhesion and motility. |
| H0517 |
AF700 Anti-Human CD68 (Y1/82A) mAb |
CD68, also known as Scavenger receptor class D member 1 (SCARD1), Macrosialin, or GP110, is a 110 kDa type I transmembrane glycoprotein primarily localized in cytoplasmic granules of monocytes, macrophages, dendritic cells, granulocytes, myeloid progenitor cells, and reportedly, a subset of CD34-positive hematopoietic bone marrow progenitor cells. CD68 belongs to the sialomucin family and functions as a scavenger receptor, capable of binding and internalizing oxidized low-density lipoproteins (LDL). Antibodies targeting CD68 are commonly used in studies of myeloid cell development and function. |
| H3997 |
AF700 Anti-Human CD7 (M-T701) mAb |
CD7 is a 40 kDa type I transmembrane glycoprotein that belongs to the immunoglobulin superfamily. The CD7 antigen is also known as Leu-9, TP41, Tp40, GP40, and T-cell leukemia antigen. It is expressed on thymocytes, T cells, pre-B cells, and NK cells. CD7 is present in reduced density on monocytic cells and cell lines. Functional studies demonstrate that crosslinking of the CD7 can induce transmembrane calcium flux in T cells. |
| H3937 |
AF700 Anti-Human CD71 (M-A712) mAb |
This antibody specifically binds to CD71 which is also known as the transferrin receptor (TFR). This type II transmembrane glycoprotein is expressed on cells as a disulfide-linked homodimer comprised of 95 kDa monomers. CD71 is expressed on activated lymphocytes, monocytes, macrophages, erythroid progenitors, brain endothelium, and most proliferating cells. CD71 is not expressed on resting lymphocytes and is upregulated during lymphocyte responses to antigens or mitogens. Through an endocytic pathway, the transferrin receptor mediates cellular iron uptake by binding and internalizing iron that is bound to transferrin. After releasing iron within the low pH endosomal environment, transferrin and its receptor can be recycled to the cell surfa |
| H0547 |
AF700 Anti-Human CD8 (SK1) mAb |
CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck. |
| H1477 |
AF700 Anti-Human CD83 (HB15e) mAb |
CD83 is a 45 kDa type I transmembrane glycoprotein that belongs to the immunoglobulin (Ig) superfamily. It is composed of a single V-type Ig extracellular domain and a C-terminal cytoplasmic tail. CD83 is primarily expressed on the surface of follicular dendritic cells, circulating dendritic cells, interdigitating dendritic cells in lymphoid tissues, in vitro-generated dendritic cells, and thymic dendritic cells. However, its expression is not limited to dendritic cells; it is also found on some germinal center B cells and certain lymphoblastoid cell lines. While the exact function of CD83 is not fully understood, it is believed to play a role in cell-cell interactions during antigen presentation. |
| H0307 |
AF700 Anti-Human CD90(P15F7) mAb |
CD90, also known as Thy-1, is a 25-35 kDa glycophosphatidylinositol-anchored membrane glycoprotein of the Ig superfamily. It is expressed on 1-4% of human fetal liver cells, cord blood cells, and bone marrow cells. CD90 is present on a subset of immature CD34+ cells and a distinct subset of mature CD34- cells that are CD3+CD4+. The CD90+CD34+ population is highly enriched for cells capable of long-term culture. The anti-CD90 antibody is useful for enriching high proliferative potential colony-forming cells (HIPP-CFC), which are primitive progenitor cells. |
| H2077 |
AF700 Anti-Human Granzyme A (CB9) mAb |
Granzyme A is a 28 kD disulfide-linked homodimeric protein and the most abundant of the proteases occurring in CTL granules. It is homologous to other serine esterases, including other granyzmes, mast cell proteases, and neutrophil cathepsins. Granzyme B is thought to be a rapidly-acting apoptotic enzyme, while Granzyme A is slow acting. |
| H0472 |
AF700 Anti-Human HLA (G46-6) mAb |
HLA-DR, a major histocompatibility complex (MHC) class II antigen, is encoded by genes within the Human Leukocyte Antigen (HLA) Complex located on chromosome 6. HLA-DR is a transmembrane heterodimeric glycoprotein composed of an α chain (36 kDa) and a β subunit (27 kDa) expressed primarily on antigen presenting cells including B cells, dendritic cells, monocytes, macrophages, Langerhans cells, and thymic epithelial cells. HLA-DR is also expressed on activated T cells. This molecule plays a major role in mediating cellular interactions during antigen presentation to CD4-positive T cells. |
| H1792 |
AF700 Anti-Human HLA-A2 (BB7.2) mAb |
HLA-A2 is a class I molecule of the major histocompatibility complex (MHC) and part of the highly polymorphic group of cell-surface proteins encoded by the MHC gene locus. It plays a crucial role in the immune response by binding and presenting small antigenic protein fragments to antigen-specific receptors on T cells (TCR). Class I MHC molecules, like HLA-A2, bind peptides derived from intracellular antigens, such as viral and some bacterial antigens, which are recognized by CD8+ T cells. The TCRs recognize these processed peptides bound to the MHC, as well as regions of the MHC molecule itself, while CD4 and CD8 accessory molecules enhance the interaction by binding non-polymorphic regions of the MHC. |
| H3667 |
AF700 Anti-Human Ig light chain kappa (MHK-49) mAb |
The Antibody reacts with both soluble and membrane human immunoglobulin light chain kappa (κ). It does not react with human immunoglobulin light chain lambda (λ) or heavy chain. |
| H3697 |
AF700 Anti-Human IgD (IA6-2) mAb |
IgD is a member of the immunoglobulin superfamily that exists in type 1-membrane (mIgD) and soluble glycoprotein forms. mIgD is expressed on mature naïve B cells (along with membrane IgM) and serves as a B-cell receptor for antigen (BCR). In response to antigen binding, the mIgD BCR, in association with other signaling molecules including CD79a and CD79b, can transduce activating or tolerizing signals intracellularly into B lymphocytes. |
| H1012 |
AF700 Anti-Human IgM (MHM-88) mAb |
IgM is the first immunoglobulin made by B cells in the immune response. Surface IgM is expressed on immature and mature B cells, while IgM heavy (μ) chain is expressed intracellularly in pre-B cells. |
| H2632 |
AF700 Anti-Human NKB1 (DX9) mAb |
CD158e1 functions as a killer cell inhibitory receptor (KIR) and is encoded by KIR3DL1 (Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail). CD158e1 is a 70 kDa glycoprotein that belongs to the Ig superfamily. It is expressed on a subset of natural killer cells and a small subset of T cells. Expression of CD158e1 has been observed to vary among individuals. KIR molecules specifically recognize a certain group of HLA class I antigens. Interaction of CD158e1 with specific HLA-B antigen on a target cell appears to inhibit cell-mediated cytotoxicity by delivering a negative signal that prevents lymphocyte activation. It is suggested that this MHC class I-KIR interaction works as a signaling mechanism that regulates |
| H0907 |
AF700 Anti-Human NKG2C/CD159c (134591) mAb |
Human NKG2C (also known as NK cell Group 2 isoform C, killer cell lectin like receptor subfamily C, member 2) is a member of the C type lectin like superfamily. NK receptors are expressed on both NK cells and cytotoxic CD8⁺ T cells and include both activating and inhibitory members. Regulation of the balance between activating and inhibitory receptors is important and its disruption has been implicated in autoimmunity. The NKG2 family includes NKG2A, -B, -C, -D, -E, -F, and -H; except for NKG2D and NKG2F, these receptors form heterodimers with CD94. NKG2C interacts with the adapter molecule DAP12 and operates as an activating receptor when paired with CD94. Human NKG2C is synthesized as a 231 amino acid protein, comprising a 70 aa cytoplasm |
| H1852 |
AF700 Anti-Human TCR Vα7.2 (3C10) mAb |
The antibody recognizes the Vα7.2 T cell antigen receptor (TCR) α-chain segment which, joined with the Jα33 segment, constitutes an invariant TCR that is a characteristic of the mucosalassociated invariant T cells (MAIT cells). MAIT cells are restricted by a nonpolymorphic class Ib major histocompatibility complex (MHC) molecule, MHC-related molecule 1 (MR1). MAIT cells are present in human blood (1-8% of T cells), mesenteric lymph nodes, liver, and intestinal mucosa. MAIT cells play a role in detecting and fighting off microbial infections |
| H0607 |
AF700 Anti-Human VEGFR2/KDR/Flk-1 (89106) mAb |
VEGFR2 (KDR/Flk-1), VEGFR1 (Flt-1), and VEGFR3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domains and kinase insert domains in their intracellular regions. The expression of VEGFR1, 2, and 3 is almost exclusively restricted to the endothelial cells. These receptors are likely to play essential roles in vasculogenesis and angiogenesis. VEGFR2 cDNA encodes a 1356 amino acid (aa) residue precursor protein with a 19 aa residue signal peptide. Mature VEGFR2 is composed of a 745 aa residue extracellular domain, a 25 aa residue transmembrane domain and a 567 aa residue cytoplasmic domain. In contrast to VEGFR1 which binds both P |
| G3412 |
AF700 Anti-Human/Mouse TREM2 (237920) mAb |
TREM2 (Triggering Receptor Expressed on Myeloid cells-2) is a 35 kDa molecular weight type I transmembrane member of the TREM family and Ig superfamily. Mature human TREM2 consists of a 156 amino acid (aa) extracellular domain (ECD) with one V-type Ig-like domain, a 21 aa transmembrane (TM) domain, and a 35 aa cytoplasmic tail. Within the ECD, human TREM2 shares 73% and 74% aa sequence identity with mouse and rat TREM2, respectively. Two closely related transcripts were reported in mouse and designated TREM2a and TREM2b. Soluble forms of the TREM2 ECD are generated by alternative splicing or proteolytic cleavage, and the cytoplasmic domain can be liberated by gamma-Secretase mediated intramembrane cleavage. It is a pattern recognition recep |
| H0127 |
AF700 Anti-IFN-lambda (4S.B3) mAb |
IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor and immune interferon that is produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemagglutinin, and other cytokines. IFN gamma is a dimeric protein consisting of two 146 amino acid subunits. IFN gamma is a glycoprotein that exists functionally as a homodimer of approximately 45 kDa. On SDS-PAGE, IFN gamma appears as a combination of 25, 20, and minor 15.5 kDa bands as a result of differential glycosylation. The biological activity of the IFN gamma homodimer is highly species specific. Human IFN gamma does not show cross-reactivity with mouse. IFN gamma exhibits functions such as a |
| G0322 |
AF700 Anti-Ki-67 (SolA15) mAb |
Ki-67 is a nuclear protein that is expressed during various stages in the cell cycle, particularly during late G1, S, G2, and M phases. The protein has a forkhead associated domain (FHA) through which it associates with euchromatin at the perichromosomal layer, the centromeric heterochromatin, and the nucleolus. Ki-67 is shown to have a cell cycle dependent topographical distribution with perinucleolar expression at G1, expression in the nuclear matrix at G2, and expression on the chromosomes during M phase. Ki-67 is commonly used as a proliferation marker because it is not detected in G0 cells, but increases steadily from G1 through mitosis. Ki-67 antibodies are useful in establishing the cell growing fraction in neoplasms. In neoplastic t |
| G0367 |
AF700 Anti-Ly-6A/E/Sca-1 (D7) mAb |
Stem Cell Antigen-1 (Sca-1) is a member of the lymphocyte antigen 6 (Ly-6) family. It is expressed on multipotent hematopoietic stem cells (HSC) and is used as a marker of HSC in mice. Sca-1 is used in combination with lineage depletion antibodies to identify murine HSC. Sca-1 can be found in fetal liver, adult bone marrow, and adult peripheral blood and spleen. Sca-1 may be involved in the regulation of B and T cell activation. |
| G3472 |
AF700 Anti-Ly-6B.2 Alloantigen (7/4) mAb |
Rat anti Mouse Ly-6B.2 monoclonal antibody, recognizes the Ly-6B.2 antigen. Ly-6B.2 is a ~25-30 kDa GPI-anchored, heavily glycosylated protein expressed on neutrophils, inflammatory monocytes and some activated macrophages. High levels of expression are seen in bone marrow, spleen, lung and lymph nodes. N-glycanase treatment of thioglycollate elicited peritoneal neutrophil lysates lowers the apparent molecular weight of Ly-6B.2 to ~15 kDa. In common with other Ly-6 antigens Ly-6B.2 demonstrates a polymorphic expression on inbred mouse strains. Rat anti mouse Ly-6B.2, recognizes the Ly-6B.2 antigen in 129J; AKR; C57BL/6; C57BL/10; C58; DBA/2; NZB; NZW; SJL; MFI; Swiss (PO) Strains whilst A2G; A/Sn; ASW; BALB/c; C3H/HEH: CBA.T6T6 are negative |
| G1972 |
AF700 Anti-MERTK (DS5MMER) mAb |
MerTK is expressed on tissue macrophages and is involved in the removal of apoptotic cells. This process relies on two soluble ligands of MerTK, Protein S and Gas6 that bind to phosphatidylserine found on the outer leaflet of the plasma membrane of cells undergoing apoptosis. Upon binding these ligands, MerTK undergoes autophosphorylation at multiple tyrosine residues that activate the PI3K and Akt pathways. This results in the phagocytosis of apoptotic cells and also results in the direct inhibition of TLR-induced production of pro-inflammatory cytokines. In addition, MerTK may function as a putative entry receptor for filoviruses. Deficiency of MerTK causes general autoimmunity, inflammation and accumulation of apoptotic bodies. MerTK is |
| G0442 |
AF700 Anti-Mouse CD107a (1D4B) mAb |
CD107a, also known as Lysosome-Associated Membrane Protein 1 (LAMP-1), is a type I transmembrane glycoprotein that serves as a key marker of lysosomes. It is composed of a 40 kDa core protein that is heavily glycosylated, resulting in a mature glycoprotein ranging from 110 to 140 kDa. CD107a is predominantly expressed in epithelial cells and macrophages across various organs. Upon cellular activation, it translocates to the cell surface of lymphocytes, macrophages, epithelial cells, endothelial cells, platelets, and tumor cells. Surface expression of CD107a is involved in intercellular and extracellular matrix adhesion and is widely used as a functional marker of cytotoxic activity in NK cells and CD8+ T cells, as well as in identifying som |
| G3007 |
AF700 Anti-Mouse CD172a/SIRPα (P84) mAb |
CD172a, also known as SIRPα, is a type I transmembrane protein with one V-set Ig-like and two C-set Ig-like domains in the extracellular portion, and two ITIM motifs and a proline-rich region in the cytoplasmic tail. CD172a is expressed by monocytes, macrophages, myeloid cells, and neuronal tissue. The phosphorylation of SIRPα ITIMs induces the recruitment and activation of the tyrosine phosphatases PTPN6 and PTPN11, resulting in the negative regulation of several biological processes. The ligands of CD172a are CD47, SP-A, and SP-D. |
| G4387 |
AF700 Anti-Mouse CD19 (1D3) mAb |
CD19, a B lymphocyte-lineage differentiation antigen and a 95-kDa transmembrane glycoprotein, is a member of the immunoglobulin superfamily and is expressed throughout B-lymphocyte development from the pro-B cell stage through mature B cells. Terminally differentiated plasma cells do not express CD19. On mature B cells, CD19 associates with CD21 (CR-2) and CD81 (TAPA-1), forming a multimolecular complex that synergizes with surface immunoglobulin to promote cellular activation. Studies in CD19-deficient mice suggest that the level of CD19 expression influences the generation and maturation of B cells in both bone marrow and peripheral tissues. B-1 lineage B cells, also called CD5+ B cells, are drastically reduced or absent in CD19-deficient |
| G4072 |
AF700 Anti-Mouse CD206/MMR (C068C2) mAb |
CD206, also known as mannose receptor (MR), is a 175 kD type I membrane protein. It is a pattern recognition receptor (PRR) belonging to the C-type lectin superfamily. MR is expressed on macrophages, dendritic cells, Langerhans cells, and hepatic or lymphatic endothelial cells. MR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine through its C-type lectin-like carbohydrate recognition domains, sulfated carbohydrate antigens through its cysteine-rich domain, and collagens through its fibronectin type II domain. MR mediates endocytosis and phagocytosis as well as activation of macrophages and antigen presentation. It plays an important role in host defense and provides a link between innate and ada |
| G4207 |
AF700 Anti-Mouse CD25/IL-2Rα (PC61.5) mAb |
Interleukin-2 receptor alpha (IL-2Rα), also known as CD25, Ly-43, p55, or Tac, is the 55 kDa ligand-binding subunit of the interleukin-2 receptor. IL-2Rα is expressed on activated mature T and B lymphocytes, thymocyte subsets, pre-B cells, and T regulatory cells. IL-2Rα plays roles in lymphocyte differentiation, activation, and proliferation. Alone, IL-2Rα binds IL-2 with relatively low affinity; however, when IL-2Rα associates with IL-2Rβ (CD122) and the common gamma chain (CD132), the complex binds IL-2 with high affinity. |
| G4642 |
AF700 Anti-Mouse CD3 (17A2) mAb |
CD3ε is one of five polypeptide chains that combine to form the TCR complex. CD3ε is expressed on T lymphocytes, NK-T cels, and to varying degrees on developing thymocytes. CD3 plays roles in TCR signaling, T lymphocyte activation, and antigen recognition. |
| G1417 |
AF700 Anti-Mouse CD317 (927) mAb |
CD317, known as BST2, tetherin, HM1.2 antigen, bone marrow stromal antigen 2, or PDCA-1, is type II transmembrane glycoprotein with a molecular mass of 29-33 kD. It is predominantly expressed on Type I IFN-producing cells (IPCs) in naïve mice, but is up-regulated on most cell types following stimulation with type I IFNs and IFN-gamma. It is highly expressed on terminally differentiated normal plasmacytoid dendritic cells and some tumor cells, such as multiple myeloma, renal cell carcinoma, and melanoma cells. BST2 is a recently identified, IFN-induced cellular response factor that blocks release of HIV-1 and other retroviruses from infected cells. BST2 has been found to be the natural ligand of ILT7 in human model. |
| G0847 |
AF700 Anti-Mouse CD38 (90) mAb |
CD38 is a 45 kD type II transmembrane glycoprotein also known as T10. It is an ADP-ribosyl hydrolase expressed at variable levels on hematopoietic cells and in some non-hematopoietic tissues (such as brain, muscle, and kidney). In humans, it is expressed at high levels on plasma cells and activated T and B cells, natural killer (NK) lymphocytes, myeloblasts, and erythroblasts. By functioning as both a cyclase and a hydrolase, CD38 mediates lymphocyte activation, adhesion, and the metabolism of cADPR and NAADP. CD31 is the ligand of CD38. |
| G4147 |
AF700 Anti-Mouse CD4 (GK1.5) mAb |
The CD4 antigen is a 55 kDa cell surface type I membrane glycoprotein belonging to the immunoglobulin superfamily. CD4 acts as a co-receptor which, in cooperation with the T cell receptor (TCR), interacts with class II MHC molecules displayed by antigen-presenting cells (APC). CD4 is expressed by the majority of thymocytes, most helper T cells, a subset of NK-T cells, and weakly by dendritic cells and macrophages. CD4 plays an important role in the development of T cells and is required for mature T cells to function optimally. |
| G0862 |
AF700 Anti-Mouse CD41 (MWReg30) mAb |
CD41 is a transmembrane glycoprotein that is encoded by Itga2b. CD41 associates with Integrin β3 chain (gpIIIa or CD61) to form the gpIIb/IIIa (CD41/CD61) complex. CD41/CD61 is expressed on platelets, megakaryocytes, and early hematopoietic progenitors. The integrin complex binds to fibrinogen, fibronectin, vitronectin, von Willebrand factor, and thrombospondin. It is important for platelet adhesion and aggregation, and it may play a role in osteolytic tumor metastasis. |
| G0532 |
AF700 Anti-Mouse CD49b (DX5) mAb |
CD49b is a 150 kDa transmembrane glycoprotein that non-covalently associates with CD29 (integrin β1) to form the integrin α2β1 complex known as VLA-2. The rat anti-mouse CD49b antibody has been reported to identify the majority of NK cells and a small T-cell subpopulation in most mouse strains (e.g., A/J, AKR, BALB/c, C3H/HeJ, C57BL/6, C57BL/10, C57BR, C58, CBA/Ca, DBA/1, DBA/2, SJL, SWR, 129/J, but not NOD). The DX5 antibody also recognizes platelets that express high levels of CD49b. |
| G4417 |
AF700 Anti-Mouse CD86 (GL1) mAb |
CD86, along with CD80, is a member of the B7 family of costimulatory molecules and plays a crucial role in T cell activation and immune response regulation. CD86 is expressed at low levels on B cells, macrophages, and dendritic cells, and its expression is upregulated on B cells through various stimuli, including the BCR complex, CD40, and certain cytokine receptors. As a type I membrane protein and member of the immunoglobulin superfamily, CD86 serves as a ligand for the T cell surface proteins CD28 and CTLA-4 (CD152). The interaction between CD86 and CD28 provides a costimulatory signal essential for T cell activation during antigen presentation, while binding with CTLA-4 negatively regulates T cell activation, diminishing the immune resp |
| G1057 |
AF700 Anti-Mouse CX3CR1 (SA011F11) mAb |
CX3CR1 is a 40 kD, G-protein coupled receptor, with seven transmembrane regions. CX3CR1 is expressed by resident and alternatively activated macrophages (M2), a subset of monocytes, dendritic cells (DCs), NK cells, a subset of memory T cells, and mast cells. CX3CR1 is involved in cell recruitment during inflammation and participates in cell adhesion and extravasation from blood vessels. Its ligand is CX3CL1, also known as fractalkine or neurotactin. CX3CR1 is also a coreceptor for HIV1 and variations in this gene leads to increased susceptibility to HIV. In the brain, it is expressed by glial cells, which interact with CX3CL1 expressed by neurons. |
| G1807 |
AF700 Anti-Mouse H-2Kb (AF6-88.5) mAb |
H-2Kb is a mouse MHC class I alloantigen expressed on all nucleated cells of mice with the H-2^b haplotype. It plays a key role in presenting endogenous peptides to CD8+ T cells, enabling immune surveillance and cytotoxic T cell responses. |
| G4432 |
AF700 Anti-Mouse Ly6G (1A8) mAb |
Lymphocyte antigen 6 complex, locus G (Ly-6G), is a 21–25 kDa GPI-anchored protein expressed primarily on peripheral granulocytes and highly specific for neutrophils. Ly-6G serves as a robust marker for neutrophil identification and depletion in mice. Ly-6G modulates neutrophil migration and recruitment to sites of inflammation via interaction with β2 integrins. Its downregulation is associated with age-related functional decline in neutrophils. |
| G4342 |
AF700 Anti-Mouse Ly6G/Ly6C (RB6-8C5) mAb |
Lymphocyte antigen 6 complex, locus G (Ly-6G), also known as Ly6C, Gr-1, is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein with a molecular weight of approximately 21–25 kDa. It is commonly used as a specific marker for peripheral granulocytes, particularly neutrophils, in mice. Ly-6G is predominantly expressed on myeloid-derived cells in the bone marrow and exhibits high specificity for neutrophils, though it can also be detected on some monocytes and granulocyte subsets. This specificity makes Ly-6G a robust marker for identifying and studying neutrophil populations and their roles in immune responses in murine models. |
| G4252 |
AF700 Anti-Mouse NK1.1 (PK136) mAb |
NK1.1, also known as CD161b/CD161c, KLRB1, NKR-P1A, and Ly-55, is a type II integral membrane glycoprotein with a C-type lectin domain and is encoded by the Klrb1c/NKR-P1C gene. NK1.1 plays roles in NK cell activation and differentiation, IFN-γ production, cytotoxic granule release, and is thought to be involved in the generation of Th2 cells. NK1.1 is predominantly expressed as a disulfide-linked homodimer on NK cells; however, it is also expressed on NK-T cells, a rare population of T lymphocytes. NK1.1 is only expressed by C57BL/6, FVB/N, and NZB strains of mice and not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129 strains. |
| G1672 |
AF700 Anti-Mouse TCR Vα2 (B20.1) mAb |
TCR Vα2 is a distinct T-cell receptor (TCR) subfamily found in mice with the a, b, and c haplotypes. The TCR α chain complexes with the TCR β chain in 95% of T cells, forming the T cell receptor (α/β TCR), while the remaining 5% of T cells express gamma (γ) and delta (δ) chains (γ/δ TCR). TCR Vα2 represents a specific variant of the TCR α chain that plays a role in antigen recognition and is useful in the study of T-cell function and immune responses in mice with these specific haplotypes. |
| G4357 |
AF700 Anti-Mouse Ter-119 (TER-119) mAb |
TER-119 is a lineage marker for erythroid cells from early proerythroblast to mature erythrocyte stages in adult blood, spleen, and bone marrow. It is also present in yolk sac, and fetal and newborn liver. The TER-119 antigen is not expressed by cells of earlier erythroid development at BFU-e (blast-forming unit erythroid) stage or CFU-e (colony-forming unit erythroid) stage. |
| G0292 |
AF700 Anti-TCR-β (H57-597) mAb |
The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system c |
| G4192 |
AF700 Mouse IgG1 isotype control (MOPC-21) |
Mouse IgG1 isotype control is a mouse myeloma protein. It was selected as an isotype control following screening for low background on a variety of mouse and human tissues. |
| G0637 |
AF700 Rat IgG2a kappa Isotype Control (eBR2a) |
Rat IgG2a is an immunoglobulin subclass that is commonly used in research and diagnostic applications. It is produced by the rat immune system and is known for its ability to activate complement and mediate antibody-dependent cell-mediated cytotoxicity (ADCC). Rat IgG2a has a molecular weight of approximately 160 kDa and is composed of two heavy chains and two light chains. It is often used as a control or reference antibody in experiments involving rat models, and is also commonly used in flow cytometry and immunohistochemistry applications.
|
| G0892 |
AF700 Rat IgG2b kappa Isotype Control (eB149/10H5) |
Rat IgG2b is a protein-coding gene that encodes for the immunoglobulin G2b (IgG2b) subclass of rat antibodies. IgG2b is a major subclass of rat immunoglobulins that plays a crucial role in the immune response by neutralizing pathogens and promoting opsonization. Rat IgG2b is commonly used in research applications, such as in immunohistochemistry, flow cytometry, and Western blotting.
|
| S5303 |
Afalanine (N-Acetyl-DL-phenylalanine) |
Afalanine (N-Acetyl-DL-phenylalanine, Afalanine) acts as an antidepressant and a metabolite. |
| S1011 |
Afatinib |
Afatinib inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively. Afatinib induces autophagy. |
| S7810 |
Afatinib Dimaleate |
Afatinib Dimaleate irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant. Afatinib (BIBW2992) Dimaleate induces autophagy. |
| E4819 |
Afatinib free base |
Afatinib free base (Gilotrif, BIBW2992, Boehringer Ingelheim) is a second-generation tyrosine kinase inhibitor (TKI) that irreversibly inhibits EGFR and HER2, with IC50 of 0.5 nM, 0.4 nM, 14 nM and 1 nM for wild-type EGFR, EGFR-L858R, HER2, ErbB4, respectively. |
| E2649 |
Afatinib impurity 11 |
Afatinib impurity 11 is an impurity of afatinib, an EGFR family inhibitor. |
| E1016 |
Aficamten (CK-274) |
Aficamten (CK-274, CK 3773274) is a novel cardiac myosin inhibitor that reduces myocardial contractility in vitro and in vivo with an IC50 of 1.4 μM.
|
| E7037 |
Aflatoxin B1 |
Aflatoxin B1 (AFB1) is a highly genotoxic and carcinogenic mycotoxin linked to hepatocellular carcinoma (HCC) through oxidative stress, cytotoxicity, and DNA damage. Its major metabolite, AFB1-2,3-oxide, covalently binds DNA, forming the predominant adduct 2,3-dihydro-2-(N7-guanyl)-3-hydroxyaflatoxin B1, crucial in its carcinogenic mechanism. |
| S3663 |
Afloqualone |
Afloqualone (AFQ, HQ-495) is a quinazolinone family GABAergic drug with muscle-relaxant and sedative effects, showing the agonist activity at the β subtype of the GABAa receptor. |
| A4048 |
Afm24 (Anti-EGFR & Fc-gamma-RIIIA) |
Afm24 is a human, tetravalent bispecific antibody targeting EGFR on tumor cells and the human low affinity IgG Fc region receptor IIIA (FCGR3A; CD16A) on innate immune cells. It enhances NK cell-mediated cytotoxicity and macrophage-driven phagocytosis, making it a promising immunotherapy with reduced EGFR-related toxicities for cancer treatment. M.W 196.34 kDa. |
| E1126 |
AFN-1252 |
AFN-1252 (Debio 1452) is a potent inhibitor of enoyl-acyl carrier protein reductase (FabI), inhibits all clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis at concentrations of ≤0.12 μg/ml. |
| E2848 |
Afoxolaner |
Afoxolaner (NexGard) is a new insecticide/acaricide molecule from the isoxazoline family that acts on the insect gamma-aminobutyric acid receptor (GABA) and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod. |
| S7521 |
Afuresertib (GSK2110183) |
Afuresertib (GSK2110183) is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2.
|
| E4992 |
Afuresertib hydrochloride |
Afuresertib hydrochloride (GSK 2110183 hydrochloride, LAE002 hydrochloride) is an orally bioavailable, selective, ATP-competitive and potent inhibitor of pan-Akt kinase with Ki values of 0.08 nM, 2 nM, 2.6 nM for Akt1/Akt2/Akt3 respectively. |
| E2828 |
AG 1295 |
AG 1295 is a selective and specific inhibitor of platelet-derived growth factor receptor (PDGFR) tyrosine-kinase. It inhibits PDGFR autophosphorylation with IC50 values of 0.3-0.5 μM in membrane autophosphorylation assays, respectively. |
| S6509 |
AG 494 |
AG-494, a member of the tyrphostin family of tyrosine kinase inhibitors, is a potent inhibitor of EGF receptor autophosphorylation (IC50=1.2 μM) and EGF-dependent cell growth (IC50=6 μM). |
| S6525 |
AG 555 |
AG-555 (Tyrphostin B46) is an inhibitor of tyrosine kinase, interacts directly with topoisomerase I, thus preventing DNA relaxation. It inhibits EGFR with an IC50 of 0.7 μM. |
| S0736 |
AG 556 |
AG-556 is a potent EGFR tyrphostin inhibitor with an IC50 of 5µM which suppresses the EGF-induced growth of HER14 cell. |
| E4449 |
AG 825 |
AG-825 (Tyrphostin AG-825) is a potent and selective inhibitor of ErbB2 with IC50 values of 0.15 µM. It also inhibits PDGFR autophosphorylation with IC50 value of 40 µM. It exhibits anti-cancer activity and significantly induces apoptosis in cancer cells. |
| S1234 |
AG-1024 |
AG-1024 (Tyrphostin, AGS 200) inhibits IGF-1R autophosphorylation with IC50 of 7 μM, is less potent to IR with IC50 of 57 μM and specifically distinguishes between InsR and IGF-1R (as compared to other tyrphostins). |
| S0718 |
AG-120 (racemic) |
AG-120 (racemic), the racemic mixture of AG-120, is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) with potential antineoplastic activity. |
| S6596 |
AG-126 |
AG126 is a tyrosine kinase inhibitor which selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM. |
| S2211 |
AG-13958 |
AG-13958 (AG-013958), a VEGFR tyrosine kinase inhibitor, is in clinical development with ST administration for treatment of choroidal neovascularization associated with age–related macular degeneration (AMD). |
| S2178 |
AG-14361 |
AG14361 is a potent inhibitor of PARP1 with Ki of <5 nM in a cell-free assay. It is at least 1000-fold more potent than the benzamides. |
| S2728 |
AG-1478 |
AG-1478 is a selective EGFR inhibitor with IC50 of 3 nM in cell-free assays, almost no activity on HER2-Neu, PDGFR, Trk, Bcr-Abl and InsR. AG-1478 (Tyrphostin AG-1478) inhibits encephalomyocarditis virus (EMCV) and hepatitis c virus (HCV) by targeting phosphatidylinositol 4-kinase IIIα (PI4KA). |
| S0151 |
AG-1557 |
AG-1557 is a specific and ATP competitive inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase. |
| S8009 |
AG-18 |
AG-18 (RG-50810, Tyrphostin A23, TX 825) inhibits EGFR with IC50 of 35 μM. |
| S9872 |
AG-270 |
AG-270 is a potent and non-competitive methionine adenosyltransferase 2A (MAT2A) inhibitor which lessens the intracellular SAM levels and MTAP-null–selective antiproliferative activity. |
| S1143 |
AG-490 |
AG-490 is an inhibitor of EGFR with IC50 of 0.1 μM in cell-free assays, 135-fold more selective for EGFR versus ErbB2, also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src. |
| S9776 |
AG-636 |
AG-636 is an orally available inhibitor of dihydroorotate dehydrogenase (DHODH) with potential antineoplastic activity. |
| S1054 |
AG99 |
AG99 (Tyrphostin 46,Tyrphostin A46,Tyrphostin B40) is a potent and selective inhibitor of EGFR. |
| E4000 |
Agar |
Agar is a jelly like substance that contains agarose and agar gel isolated from the cell walls of red algae species such as Gelidium and Gracilaria (Ogonori). It is widely used in food additives, plant tissue culture, microorganisms culture media, fingerprint recognition, and medical fields. |
| E3500 |
Agaric Extract |
Agaric Extract is extracted from agaricales, which has anti-inflammatory and related pharmacological activities. |
| E3330 |
Agaricus blazei Extract |
Agaricus blazei Extract is extracted from Agaricus blazei Murill, which is believed to have anti-tumor and antioxidative activities. |
| E7236 |
Agarose,Low melting point |
Agarose, Low melting point is a hydroxyethylated modification of agarose derived from seaweed genera Gelidium and Gracilaria. It is used when the isolation of separated DNA fragments is desired and in techniques like pulsed-field gel electrophoresis and capillary electrophoresis for genetic analysis. |
| S3263 |
Agarotetrol |
Agarotetrol is a chromone derivative found in high concentrations in the water-extract fraction of agarwood. Agarotetrol contributes to the fragrance of agarwood through the generation of LACs upon heating. |
| E3322 |
Agastache rugosa Extract |
Agastache rugosa Extract is extracted from Agastache rugosa . |
| S8015 |
Agerafenib (CEP-32496) |
Agerafenib (CEP-32496) is a highly potent inhibitor of BRAF(V600E/WT) and c-Raf with Kd of 14 nM/36 nM and 39 nM, also potent to Abl-1, c-Kit, Ret (c-Ret), PDGFRβ and VEGFR2, respectively; insignificant affinity for MEK-1, MEK-2, ERK-1 and ERK-2. Phase 1/2. |
| S6420 |
AGI 1067 |
AGI-1067 is a novel, phenolic, intra- and extracellular antioxidant that inhibits the expression of a number of proinflammatory genes involved in atherosclerosis. |
| E1806 |
AGI-24512 |
AGI-24512 is an inhibitor of MAT2A with an IC50 of 8 nM. It increases R-Loop formation and DNA damage in MTAP-deleted and WT cell models. It also exhibits anti-proliferative activity in vitro. |
| S7185 |
AGI-5198 |
AGI-5198 (IDH-C35) is the first highly potent and selective inhibitor of IDH1 R132H/R132C mutants with IC50 of 0.07 μM/0.16 μM. |
| S7577 |
AGK2 |
AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels. |
| E7470 |
AGN 194310 |
AGN 194310 (VTP-194310) is a high affinity, potent and selective retinioic acid receptors (RARs) pan-antagonist with Kd values of 3 nM, 2 nM, 5 nM for RARα, RARβ, RARγ, respectively. AGN 194310 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. |
| S1243 |
Agomelatine (S20098) |
Agomelatine (Valdoxan, Melitor, Thymanax,S20098) is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. |
| E6011 |
Agomelatine hydrochloride |
Agomelatine hydrochloride (S-20098 hydrochloride) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. It is also a selective antagonist of 5-HT2C receptors with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively. Blockade of these receptors enhances adrenergic and dopaminergic transmission in the frontocortical regions. |
| E3747 |
Agrimonia pilosa Extract |
Agrimonia pilosa Extract is obtained from Agrimonia pilosa Ledeb., which has shown remarkable effectiveness in the treatment of various diseases, especially enteritis, gastric ulcers, and gastrointestinal bleeding. |
| E1152 |
AGX51 |
AGX51, a first-in-class pan-Id (inhibitors of DNA-binding/differentiation proteins) antagonist and degrader, inhibits the Id1-E47 interaction, leading to ubiquitin-mediated degradation of Ids, cell growth arrest, and reduces viability, also inhibits pathologic ocular neovascularization. |
| E0648 |
AH 6809 |
AH 6809 is an antagonist of EP and DP receptor, with Kis of 1217, 1150, 1597, and 1415 nM for the cloned human EP1, EP2, EP3-III, and DP receptor respectively. AH 6809 has a Ki of 350 nM for mouse EP2 receptor. |
| S9477 |
AH7614 |
AH7614 (compound 39) is a selective FFA4 (GPR120) antagonist with pIC50s of 7.1 for human FFA4 and 8.1 for mouse FFA4. |
| F0827 |
AhR Rabbit mAb |
Ah Receptor,AhR,Aryl hydrocarbon Receptor |
| S7814 |
AI-10-49 |
AI-10-49 is a selective inhibitor of the binding of CBFβ-SMMHC to RUNX1 with IC50 of 260 nM. |
| S1802 |
AICAR (Acadesine) |
AICAR (Acadesine, NSC105823, AICA Riboside), an AMPK activator, results in accumulation of ZMP, which mimics the stimulating effect of AMP on AMPK and AMPK kinase. AICAR (Acadesine) induces mitophagy. Phase 3. |
| E5784 |
AICAR phosphate |
|
| F3339 |
AIF (F11K24) Rabbit mAb |
|
| F0268 |
AIF Rabbit mAb |
|
| S6885 |
Ailanthone |
Ailanthone (AIL, Δ13-Dehydrochaparrinone), a natural anti-hepatocellular carcinoma (HCC) component in Ailanthus altissima, induces G0/G1-phase cell cycle arrest by decreasing expression of cyclins and CDKs and increases expression of p21 and p27. Ailanthone triggers DNA damage characterized by activation of the ATM/ATR pathway. Ailanthone induces apoptosis which is mitochondrion-mediated and involves the PI3K/AKT signaling pathway in Huh7 cells. Ailanthone is also a potent inhibitor of both full-length Androgen Receptor (AR-FL) and constitutively active truncated AR splice variants (AR-Vs, AR1-651) with IC50 of 69 nM and 309 nM, respectively. |
| S2212 |
AIM-100 |
AIM-100 is a potent small molecule inhibitor of Ack1 with IC50 of 24nM. |
| F0874 |
Aiolos Rabbit mAb |
Aiolos,IKZF3 |
| E3447 |
Air-Plant herb Extract |
Air-Plant Herb Extract is extracted from Tillandsia, which is a novel therapeutic agent for the control of Type 2 Diabetes. |
| E7399 |
Ajmalicine |
Ajmalicine (Raubasine) is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine is an reversible but non-competitive nicotine receptor full inhibitor, with an IC50 of 72.3 μM. Ajmalicine also can be used as anti-hypertensive, and serpentine, with sedative activity. |
| S5371 |
Ajmaline |
Ajmaline (Cardiorythmine, Tachmalin), found in the root of Rauwolfia serpentina, is a class Ia antiarrhythmic agent. |
| E5964 |
AkaLumine hydrochloride |
AkaLumine hydrochloride is a luciferin analogue, with a Km of 2.06 μM for recombinant firefly luciferase (Fluc) protein. Its near-infrared emission peak enables deep tissue imaging and enhances target-detection sensitivity, allowing more accurate, non-invasive bioluminescence imaging at very low concentrations in animal models. |
| A5742 |
AKAP14 Rabbit Recombinant mAb |
AKAP14 Rabbit Recombinant mAb detects endogenous levels of total AKAP14. |
| S9024 |
AKBA (3-O-Acetyl-11-keto-β-boswellic acid) |
AKBA (3-O-Acetyl-11-keto-β-boswellic acid), the major active ingredient of the gum resin from Boswellia serrata and Boswellia carteri Birdw., exerts anti-inflammatory therapeutic effects and noncompetitively inhibits 5-lipoxygenase, topoisomerase, and leukocyte elastase. |
| S5455 |
Akebia saponin D |
Akebia saponin D (Asperosaponin VI), the most abundant constituent of the rhizome of Dipsacus asper, has been used for the treatment of lower back pain, traumatic hematoma and bone fractures. |
| E3509 |
Akebia quinata Extract |
Akebia Quinata Extract is extracted from akebia quinata, which exerts anti-obesity and hypolipidemic effects. |
| E0338 |
AKI603 |
AKI-603 is an inhibitor of Aurora kinase A (AurA), which is developed to overcome resistance mediated by BCR-ABL-T315I mutation. |
| S5557 |
Aklomide |
Aklomide (2-Chloro-4-nitrobenzamide) is a coccidiostat and used to fight disease, parasites and insects that infest poultry. |
| S6801 |
AKOS B018304 |
AKOS B018304 (C6;NSC 43396) is an arylalkylidene derivative with a polar substitution at the para-position. It functions as an inhibitor of ΔFosB by allosterically inhibiting its binding to DNA. It disrupts ΔFosB binding to TMR-cdk5 with an IC50 value of 10.1 μM and also induces a structural change in ΔFosB that prevents the protein from binding to DNA. |
| S0764 |
AKR1C1-IN-1 |
AKR1C1-IN-1 is a potent and selective inhibitor of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) with Ki of 4 nM, 87 nM, 4.2 μM and 18.2 μM for AKR1C1, AKR1C2, AKR1C3 and AKR1C4, respectively. |
| S0468 |
AKR1C3-IN-1 |
AKR1C3-IN-1 is a highly potent inhibitor of aldo-keto reductaseAKR1C3 with an IC50 of 13 nM. It can be used in research targeting both breast and prostate cancer. |
| F3511 |
Akt (pan) (C11A22) Rabbit mAb |
Akt,Akt (pan),Akt/PKB,AKT1 + AKT2 + AKT3,Akt1/2/3,AKT3 + AKT2 + AKT1,pan-AKT |
| F0004 |
Akt (pan) Rabbit mAb |
RAC-beta serine/threonine-protein kinase, Protein kinase Akt-2, PKB beta 1, RAC-PK-beta, RAC-gamma serine/threonine-protein kinase, Akt-3, PKB gamma, RAC-PK-gamma, STK-2, AKT3, PKBG, RAC-alpha serine/threonine-protein kinase, PKB, PKB alpha, Proto-oncogene c-Akt, RAC-PK-alpha, AKT1 |
| E5820 |
AKT Kinase Inhibitor |
AKT Kinase Inhibitor is an inhibitor of Akt that reverses the protective effects of Tadalafil (TAD) in LPS-induced RWPE-1 cells by decreasing cell viability, promoting apoptosis, and increasing pro-inflammatory cytokine levels. |
| F2571 |
AKT1 + AKT2 Rabbit mAb |
|
| F0217 |
Akt1 Rabbit mAb |
|
| F0218 |
Akt2 Rabbit mAb |
|
| F0670 |
Akt3 Rabbit mAb |
|
| S7776 |
Akti-1/2 |
Akti-1/2 (Akt Inhibitor VIII) is a highly selective Akt1/Akt2 inhibitor with IC50 of 58 nM/210 nM, respectively, about 36-fold selectivity for Akt1 over Akt3. Akti-1/2 induces apoptosis. |
| S6608 |
AL082D06 |
AL082D06 is a nonsteroidal glucocorticoid receptor (GR) antagonist with no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins. |
| S5801 |
Ala-Gln |
Ala-Gln (l-alanyl-l-glutamine), a dipeptide composed of alanine and Gln, is an alternative supplement to L-glutamine in the production of biopharmaceuticals with better solubility and stability than glutamine (Gln). |
| E7425 |
Alagebrium chloride |
Alagebrium chloride is a breaker of AGE-based cross-links that targets and cleaves preformed AGE-derived protein cross-links to reduce tissue stiffness and organ damage. It also inhibits neointimal proliferation in a streptozotocin (STZ)-induced diabetic rat carotid artery balloon injury model. |
| P1107 |
Alamandine |
Alamandine is a component of the renin-angiotensin system, which regulates blood pressure. |
| S8318 |
Alantolactone |
Alantolactone, a naturally occurring eudesmane-type sesquiterpene lactone (SL), could induce activin/SMAD3 signaling and disrupt Cripto-1/activin receptor type II A interaction. |
| A5239 |
Alas1 Rabbit Recombinant mAb |
Alas1 Rabbit Recombinant mAb detects endogenous level of total Alas1. |
| F3432 |
ALAS2/ASB C-terminal Rabbit mAb |
ALAS2,ALAS2/ASB |
| S1640 |
Albendazole |
Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations. |
| S1836 |
Albendazole Oxide |
Albendazole Oxide (Ricobendazole,Albendazole sulfoxide) is a tubulin polymerization or assembly inhibitor, used for the treatment of a variety of parasitic worm infestations. |
| S3734 |
Albiglutide Fragment |
Albiglutide fragment is one copy of a 30-amino-acid sequence of modified human GLP-1 (fragment 7-36). |
| E3256 |
Albiziae Cortex Extract |
Albiziae Cortex Extract is extracted from Albiziae Cortex, which has sedative-hypnotic effects and neuroprotective ability. |
| E3255 |
Albiziae Flos Extract |
Albiziae Flos Extract is extracted from Flos albiziae, which is used for the treatment of insomnia and anxiety in traditional medicine. |
| F3687 |
Albumin Rabbit mAb |
|
| E0446 |
ALC-0159 |
ALC-0159 is a polyethylene glycol (PEG) lipid conjugate. ALC-0159 allows forming a hydrophilic layer that sterically stabilizes the nanosystem, contributing to storage stability and reducing non-specific binding to proteins. |
| E0139 |
ALC-0315 |
ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization.
|
| S4625 |
Alcaftadine |
Alcaftadine (Lastacaft, R89674) is a high affinity ligand for the H1 receptor, with a pKi (8.5) that is comparable with that of other H1 antihistamines. Alcaftadine is also an antagonist for H2 and H4 receptors with no affinity for the H3 receptor. |
| E7059 |
Alcian Blue 8GX |
Alcian Blue 8GX is a commonly used phthalocyanine dye that binds to glycoproteins and glycosaminoglycans. Alcian Blue 8GX has a wide range of applications in biological staining, including proteins in brain tumors and DNA in cells and tissues. |
| F1023 |
ALDH1A1 Rabbit mAb |
|
| A5853 |
ALDH1A2 Rabbit Recombinant mAb |
ALDH1A2 Rabbit Recombinant mAb detects endogenous levels of total ALDH1A2 |
| F2628 |
Aldh1L1 Mouse mAb |
|
| F2805 |
Aldolase + Aldolase B + Aldolase C Rabbit mAb |
|
| F0875 |
Aldolase A Rabbit mAb |
ALDOA,Aldolase,Aldolase A |
| A5502 |
Aldolase Rabbit Recombinant mAb |
Aldolase Rabbit Recombinant mAb detects endogenous level of total Aldolase. |
| E1323 |
Aldometanib |
Aldometanib (LXY-05-029) is a selective inhibitor of aldolase (ALDOA) with an IC50 of 50 uM in in vitro enzymatic assays. It also activates lysosomal AMPK by blocking FBP-aldolase binding, mimicking glucose starvation and improving metabolic health without causing hypoglycemia. |
| E4707 |
Aldosterone |
Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level. |
| E8258 |
Aldosterone-d7 |
Aldosterone-d7 is the deuterated form of aldosterone. Aldosterone is the primary mineralocorticoid. |
| E1850 |
Aldoxorubicin |
Aldoxorubicin (INNO-206) is an albumin-binding proagent of Doxorubicin (DNA topoisomerase II inhibitor), which is released from albumin under acidic conditions. Aldoxorubicin (INNO-206) has potent antitumor activities in various cancer cell lines and in murine tumor models. |
| S2762 |
Alectinib |
Alectinib is a potent ALK inhibitor with IC50 of 1.9 nM in cell-free assays, sensitive to L1196M mutation and higher selectivity for ALK than PF-02341066, NVP-TAE684 and PHA-E429. |
| S5232 |
Alectinib (CH5424802) hydrochloride |
Alectinib (AF802, CH5424802, RO5424802, RG-7853) is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase. |
| S1624 |
Alendronate sodium trihydrate |
Alendronate sodium trihydrate (G-704650, MK-217), a nitrogen-containing bisphosphonate, is a potent inhibitor of bone resorption used for the treatment and prevention of osteoporosis. |
| S5536 |
Alendronic Acid |
Alendronic acid (alendronate) is a nitrogen-containing, second generation bisphosphonate used for osteoporosis, osteogenesis imperfecta, and several other bone diseases. |
| S5126 |
Aleuritic Acid |
Aleuritic Acid (Aleuritolic acid, 9,10,16-trihydroxy-palmitic acid), a major constituent acid of lac resin (shellac), is isolated from the resin and mainly used in the perfumery industry as a starting material for the preparation of "musk" aroma compounds as well as medicinal and bioactive compounds. |
| E1780 |
Alexidine dihydrochloride |
Alexidine dihydrochloride, a dibiguanide compound, is an effective and selective inhibitor of protein tyrosine phosphatases localized to mitochondrion 1 (PTPMT1) with an IC50 of 1.08 μM in vitro. It has the potential to treat type II diabetes. |
| S1468 |
Alfacalcidol |
Alfacalcidol (1-hydroxycholecalciferol) is a non-selective VDR activator medication. |
| S6868 |
Alflutinib (Furmonertinib) mesylate |
Alflutinib (Furmonertinib) mesylate is a third-generation epidermal growth factor receptor (EGFR) inhibitor that inhibits both EGFR-sensitive mutations and T790M mutations. Alflutinib (AST2818), primarily metabolized by CYP3A4, is also a potent CYP3A4 inducer with EC50 of 0.25 μM. |
| S5766 |
Alfuzosin |
Alfuzosin(SL 77499), a quinazoline derivative, is a selective and competitive α1-adrenoceptor antagonist. |
| S1409 |
Alfuzosin HCl |
Alfuzosin HCI(SL 77499 HCl) is an alpha1 receptor antagonist used to treat benign prostatic hyperplasia (BPH). |
| E5811 |
ALG-055009 |
ALG-055009 is a potent and selective agonist of thyroid hormone receptor beta (THR-β), used for treating MASH (Metabolic Dysfunction-Associated Steatohepatitis). |
| S1928 |
Alibendol |
Alibendol (EB 1856) is an antispasmodic,choleretic, and cholekinetic. |
| S5730 |
Alimemazine Tartrate |
Alimemazine (Trimeprazine Tartrate, Methylpromazine Tartrate) is a phenothiazine derivative that is used as an antipruritic. |
| A2047 |
Alirocumab (anti-PCSK9) |
Alirocumab (anti-PCSK9) works by inhibiting the PCSK9 protein, which binds to the low-density lipoprotein receptor (LDLR) and causes receptor degradation, removing less LDL cholesterol from the circulation. |
| S1133 |
Alisertib (MLN8237) |
Alisertib (MLN8237) is a selective Aurora A inhibitor with IC50 of 1.2 nM in a cell-free assay. It has >200-fold higher selectivity for Aurora A than Aurora B. Alisertib induces cell cycle arrest, apoptosis and autophagy. Phase 3. |
| S5767 |
Aliskiren |
Aliskiren(CGP 60536) is a renin inhibitor with antihypertensive activity. |
| S2199 |
Aliskiren Hemifumarate |
Aliskiren hemifumarate(CGP 60536 hemifumarate, CGP60536B hemifumarate, SPP 100 hemifumarate) is a direct renin inhibitor with IC50 of 1.5 nM. |
| S9277 |
Alisol A |
Alisol A is one of the major active triterpenes isolated from Rhizoma Alismatis (RA), a famous Traditional Chinese Medicine widely used for diuretic, hypolipidemic, anti-nephrolithic, anti-atherosclerotic, anti-inflammatory and anti-diabetic purposes. |
| S9276 |
Alisol B |
Alisol B, a triterpene from Alismatis rhizoma, induces Bax up-regulation and nuclear translocation, the activation of initiator caspase-8 and caspase-9, and executor caspase-3, suggesting the involvement of both extrinsic and intrinsic apoptosis pathways. |
| S6865 |
Alisporivir |
Alisporivir (Debio-025) is a cyclophilin inhibitor molecule with potent anti-hepatitis C virus (HCV) activity. |
| S4257 |
Alizapride HCl |
Alizapride HCl(Alizapride hydrochloride) is a dopamine receptor antagonist used for the theropy of nausea and vomiting. |
| S2526 |
Alizarin |
Alizarin is a red coloring mordant dye extracted from the roots of madder plants (Rubia tinctorum L). Alizarin strongly inhibits P450 isoform CYP1A1, CYP1A2, and CYP1B1 with IC50 of 6.2 μM, 10.0 μM, and 2.7 μM, respectively in an enzymatic assay. There are also literature reports Alizarin increases the CYP1A1 enzymatic activity and acts as an agonist to the AHR receptor in HepG2 cells. |
| S5974 |
Alizarin Red S |
Alizarin Red S sodium (Alizarin red S mono sodiumsalt, ARS sodium, C.I. Mordant Red 3, C.I 58005, Alizarin Carmine, Alizarin Red, Alizarin sodium monosulfonate, Alizarin sulfonate sodium, Alizarinsulfonic acid sodium salt, Sodium alizarinsulfonate) is an anthraquinone dye that has been used to evaluate calcium-rich deposits by cells in culture. |
| E2836 |
ALK inhibitor 1 |
ALK inhibitor 1 (compound 17) is a potent pyrimidin ALK inhibitor which can inhibit testis-specific serine/threonine kinase (TSSK2; IC50=31 nM) and focal adhesion kinase (FAK; IC50=2 nM). |
| A5111 |
Alkaline Phosphatase Rabbit Recombinant mAb |
Alkaline Phosphatase Rabbit Recombinant mAb detects endogenous levels of total alkaline phosphatase. |
| E7440 |
Alkaline phosphatase, Bovine intestine |
Alkaline phosphatase, Bovine intestine (Apase) is a membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase can be used in molecular biology and enzyme-free analysis. Inhibition of tissue nonspecific alkaline phosphatase can block intracellular lipid accumulation. |
| L7900 |
Alkaloid Compound Library |
A unique collection of 433 alkaloid compounds used for high throughput screening(HTS) and high content screening(HCS). |
| E2829 |
Alkannin |
Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2), without inhibiting PKM1 and pyruvate kinase-L (PKL). |
| E1637 |
ALKBH5 inhibitor 1 (compound 3) |
ALKBH5 inhibitor 1 (compound 3) is an inhibitor of the RNA m6A Demethylase ALKBH5, with an IC50 value of 0.84 μM. It also exhibits potent antiproliferative activity. |
| E1638 |
ALKBH5 inhibitor 2 (Cpd 20m) |
ALKBH5 inhibitor (Cpd 20m) is a potent and selective inhibitor of RNA m6A demethylase AlkB homolog 5 ALKBH5 with IC50 of 21 nM. |
| F1663 |
ALKBH5 Rabbit mAb |
|
| E7306 |
alkyl-dimethyl-benzylammonium chloride |
alkyl-dimethyl-benzylammonium chloride is a potent anti-microbial agent, used as a preservative in eye drops. |
| E0471 |
Alkyne tyramide |
Alkyne tyramide is a clickable ascorbate peroxidase 2 (APEX2) probe, substantially improves APEX-labeling efficiency in intact yeast cells, also facilitates the identification of APEX-labeling sites, allowing the unambiguous assignment of membrane topology of mitochondrial proteins.
|
| E7738 |
Alkynyl myristic acid |
Alkynyl myristic acid, an alkyl chain-based PROTAC linker is used in the synthesis of PROTACs. Alkynyl myristic acid contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. |
| E8031 |
Alkynyl Palmitic Acid |
Alkynyl Palmitic Acid is a synthetic palmitate analog featuring a terminal alkyne group. It is incorporated into proteins by palmitoyltransferases, enabling the detection of protein palmitoylation through click chemistry. It can also serve as an alkyl chain-based linker for the synthesis of PROTACs and other bioconjugates. |
| S6132 |
All trans-Retinal |
All trans-Retinal (Retinaldehyde, Vitamin A aldehyde, Retinene), a component of the retinoid cycle, is converted to retinoic acid in vivo by the action of retinal dehydrogenase. Retinoic acid is a ligand for both RAR and RXR. All trans-retinal ias a potent photosensitizer. |
| S3856 |
Allantoin |
Allantoin (Glyoxyldiureide, 5-Ureidohydantoin), produced from uric acid, is a major metabolic intermediate in most organisms including animals, plants and bacteria. |
| S3860 |
Allicin |
Allicin (Diallyl Thiosulfinate), the main biologically active component of the freshly crushed garlic extracts, possesses various biological activities including antibacterial, antifungal and antiparasitic effects., Allicin (Diallyl Thiosulfinate), the main biologically active component of the freshly crushed garlic extracts, possesses various biological activities including antibacterial, antifungal and antiparasitic effects. |
| S9397 |
Alliin |
Alliin (S-allyl cysteine sulfoxide, ACSO, 3-(Allylsulphinyl)-L-alanine) is a sulfoxide that is a natural constituent of fresh garlic. |
| S2185 |
Allitinib tosylate |
Allitinib tosylate (AST-1306 TsOH, AST-6) is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, also effective in mutation EGFR T790M/L858R, more potent to ErbB2-overexpressing cells, 3000-fold selective for ErbB family than other kinases. |
| S9347 |
Allitol |
Allitol (Allodulcitol) is a rare polyol found in nature that is useful not only as a sweetener, but also as the raw material for production of chemical compounds. |
| E3806 |
Allium Cepa Extract |
Allium Cepa Extract is drawed from Allium cepa Linnaeus, which has hypoglycaemic, anti-diabetic, hypolipidemic and antimicrobial functions. |
| E3776 |
Allium Macrostemnon Extract |
Allium Macrostemnon Extract is extracted from Allium macrostemon Bunge., which has been extensively proven such as antioxidant activity, antiplatelet aggregation, vasodilation and antidepressant-like activity. |
| E0787 |
ALLO-2 |
ALLO-2 is a potent antagonist of both wild-type mouse Smo and drug-resistant D473H mutant human Smo that inhibits Smo agonist inhibited Gli-Luc activity in TM3-Gli-Luc cells with IC50 of 6 nM. |
| E2430 |
Allocholic acid |
Allocholic acid is a typically fetal bile acid found in vertebrates and reappears during liver regeneration and carcinogenesis. Allocholic acid is also a potent and specific stimulant of the adult olfactory system. |
| S5805 |
Allopregnanolone |
Allopregnanolone, a neurosteroid synthesized from progesterone in brain, acts as a highly potent positive allosteric modulator of the GABAA receptor. |
| S1630 |
Allopurinol |
Allopurinol is a purine analog inhibitor of the enzyme xanthine oxidase, used to treat gout or kidney stones, and to decrease levels of uric acid. |
| E4922 |
Allopurinol riboside |
Allopurinol riboside, a metabolite of allopurinol, competitively inhibits the action of purine nucleoside phosphorylase on inosine in vitro with a Ki value of 277 μM. It displays potent activities against parasites. |
| S1631 |
Allopurinol Sodium |
Allopurinol Sodium is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM. |
| S0917 |
Allosecurinin |
Allosecurinine (Phyllochrysine) is a Securinega alkaloid isolated from M.indica and M.discoidea with antifungal activity. |
| E0196 |
Alloxan Monohydrate |
Alloxan Monohydrate is the most popular diabetogenic agents used for assessing the antidiabetic or hypoglycemic capacity of test compounds. Alloxan Monohydrate can be used to induce animal models of Diabetes Mellitus. |
| S5427 |
Alloxazine |
Alloxazine (Isoalloxazine) is an A2 receptor antagonist, which is approximately 10-fold more selective for the A2B receptor than for the A2A receptor. |
| S6204 |
Allyl Methyl Sulfide |
Allyl Methyl Sulfide (3-Methylthio-1-propene), a bioactive organosulfur compound found in garlic, is reported to modulate disease states such as cancer and infection. |
| S5219 |
Allylestrenol |
Allylestrenol is an orally active progestagen of the 19-nortestosterone series resembling progesterone. |
| S4017 |
Allylthiourea |
Allylthiourea is a metabolic inhibitor that selective inhibits ammonia oxidation. |
| S4439 |
Almitrine mesylate |
Almitrine mesylate (Almitrine bismesylate, Almitrine dimethanesulfonate, Almitrine dimesylate), a pharmacologically unique respiratory stimulant, acts as an agonist of peripheral chemoreceptors located on the carotid bodies. Almitrine mesylate inhibits the activity of Ca2+-dependent K+ channel by decreasing its open probability with IC50 of 0.22 μM. |
| S8817 |
Almonertinib (HS-10296) |
Almonertinib (HS-10296) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR. |
| E7492 |
Almorexant |
Almorexant (ACT 078573) is an orally active, potent and competitive dual orexin receptor antagonist, with Kd values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant totally blocked the intracellular Ca2+ signal pathway. Almorexant stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis. |
| S2160 |
Almorexant HCl |
Almorexant HCl (ACT-078573) is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor, respectively. Phase 3. |
| S2096 |
Almotriptan Malate |
Almotriptan Malate (LAS 31416) is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist, used for the treatment of Migraine attacks in adults. |
| A4030 |
Alnuctamab (Anti-BCMA & CD3) |
Alnuctamab is a bispecific T-cell engager (BiTE) antibody directed against the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; TNFRSF17) and the T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. It demonstrates encouraging antitumor activity in patients with relapsed or refractory multiple myeloma. MW: 192.35 KD. |
| S8961 |
Alobresib (GS-5829) |
Alobresib (GS-5829) is a novel BET inhibitor that represents a highly effective therapeutics agent against recurrent/chemotherapy-resistant USC-overexpressing c-Myc. Alobresib (GS-5829) inhibits CLL cell proliferation and induces leukemia cell apoptosis through deregulation of key signaling pathways, such as BLK, AKT, ERK1/2, and MYC. Alobresib (GS-5829) also inhibits NF-κB signaling. |
| E3429 |
Aloe vera Extract |
Aloe vera Extract is extracted from Aloe vera, which has been traditionally used to treat skin injuries and digestive problems because of its anti-inflammatory, antimicrobial, and wound healing properties. |
| S2259 |
Aloe-emodin |
Aloe-emodin (NSC 38628, Rhabarberone) is an interferon-inducing agent with IC50 of about 1 μg/mL for JEV and of about 0.33 μg/mL for EV71. |
| S9284 |
Aloesin |
Aloesin (Aloe resin B) is a kind of herbal extraction form the aloe vera. It is a strong inhibitor of tyrosinase activity and up-regulates cyclin E-dependent kinase activity in vitro. |
| S8754 |
Alofanib (RPT835) |
Alofanib (RPT835) is a novel selective allosteric inhibitor of FGFR2 and has a dramatic inhibitory effect with IC50 <10 nM on FGF2-induced phoshphorylation of FRS2a in KATO III cells. It has no direct effect on FGF2-dependent FGFR1 and FGFR3 phosphorylation levels in either cell lines and no effects on FGF2-FGFR2 binding. |
| S5365 |
Alogliptin |
Alogliptin is a potent, selective inhibitor of the serine protease dipeptidyl peptidase IV (DPP-4) with IC50 values of 2.63 nM and exhibits greater than 10,000 fold selectivity over the closely related serine proteases DPP-8 and DPP-9. |
| S2868 |
Alogliptin (SYR-322) benzoate |
Alogliptin (SYR-322) benzoate is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. |
| S2375 |
Aloin (Barbaloin) |
Aloin (Barbaloin), a natural anthracycline from Aloe vera, is a tyrosinase inhibitor. |
| S0936 |
Aloin B |
Aloin B (Isobarbaloin), isolated from Aloe vera, is one isomer of Aloin and has anti-hepatitis B virus (HBV) acyivity. |
| S2420 |
Aloperine |
Aloperine is an isolated alkaloid in sophora plants such as Sophora alopecuroides L, and exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties. |
| S4694 |
Alosetron Hydrochloride |
Alosetron Hydrochloride (GR 68755C, GR 68755X, Lotronex) is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist. |
| S7393 |
Aloxistatin (E64d) |
Aloxistatin (E64d) is an irreversible and membrane-permeable cysteine protease inhibitor with blood platelet aggregation inhibiting activity. The cysteine protease cathepsin L is required for SARS-CoV-2 viral entry, and aloxistatin treatment reduced cellular entry of SARS-CoV-2 pseudovirions by 92.3%. |
| S2814 |
Alpelisib (BYL719) |
Alpelisib (BYL719) is a potent and selective PI3Kα inhibitor with IC50 of 5 nM in a cell-free assay, and minimal effect on PI3Kβ/γ/δ. Phase 2. |
| E8308 |
Alpelisib hydrochloride |
Alpelisib hydrochloride is a potent and selective inhibitor of PI3Kα with an IC50 of 0.005 μM, 1.2 μM, 0.29 μM, 0.25 μM for p110α, p110β, p110δ, p110γ, respectively. It exhibits good efficacy in inhibiting the growth of PI3Ka driven tumors and can be used in cancer research. |
| A5964 |
Alpha Fodrin Rabbit Recombinant mAb |
Alpha Fodrin Rabbit Recombinant mAb detects endogenous levels of total alpha fodrin. |
| A5794 |
Alpha Sarcoglycan Rabbit Recombinant mAb |
Alpha Sarcoglycan Rabbit Recombinant mAb detects endogenous levels of total Alpha Sarcoglycan. |
| S5112 |
alpha-Arbutin |
Alpha-arbutin (alpha-Arbutoside, 4-hydroxyphenyl-D-lucopyranoside) is a synthetic and functional active ingredient for skin lightening. |
| S4772 |
alpha-Asarone |
Alpha (α)-asarone (trans-Asarone) is one of the main pharmacologically active compounds present in Acorus calamus Linn (Acoraceae), Acorus tatarinowii Schott (Acoraceae), and Acorus gramineus Solander. It has anticonvulsant, neuroprotective, anxiolytic and nootropic effects. |
| S5910 |
Alpha-Estradiol |
Alpha-Estradiol (α-Estradiol, 17 alpha-Estradiol, Alfatradiol, Epiestradiol, Epiestrol, Alora, 17 α-E2), a natural, non-feminizing stereoisomer, a hormonally almost inactive isomer of physiological 17 beta-estradiol (17 β-E2), is a weak inhibitor of estrogen. |
| S3804 |
Alpha-Mangostin |
Alpha-mangostin is the main xanthone purified from mangosteen and has health promoting benefits including anti-bacterial, anti-inflammatory, anti-oxidant, anti-cancer and cardioprotective activities. alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM. Alpha-mangostin is also an agonist of human STING. |
| P1207 |
alpha-MSH TFA |
alpha-MSH TFA (α-MSH TFA, α-MSH Trifluoroacetate, alpha-MSH Trifluoroacetate,α-Melanocyte-stimulating hormone TFA, α-Melanocyte-stimulating hormone Trifluoroacetate) is a 13-amino acid peptide hormone. an endogenous MC4R agonist. alpha-MSH TFA is an endogenous MC3R and MC4R agonist with EC50s of 0.16 nM and 56 nM for hMC3R and hMC4R in Hepa cells, respectively.
|
| S5158 |
alpha-Naphthoflavone |
Alpha-Naphthoflavone (7,8-benzoflavone), a synthetic flavonoid, is a potent inhibitor of aromatase with an I50 value of 0.5 μM. |
| S3875 |
Alpinetin |
Alpinetin, a composition of Alpinia katsumadai Hayata, has been reported to have a number of biological properties, such as antibacterial, antitumor and other important therapeutic activities. Alpinetin is a flavonoid isolated from Alpinia katsumadai Hayata, activates activates PPAR-γ, with potent anti-inflammatory activity. |
| E3821 |
Alpinia Oxyphyllae Extract |
Alpinia Oxyphyllae Extract is extracted from Alpinia oxyphyllae, which has potent activities in modulating multiple signaling pathways associated with β-amyloid deposition, tau protein phosphorylation, chronic inflammation, oxidative stress. |
| E3041 |
Alpiniae Katsumadai Extract |
Alpiniae Katsumadai Extract is extracted from Alpiniae Katsumadai, which can induce growth inhibition and autophagy‑related apoptosis by regulating the AMPK and Akt/mTOR/p70S6K signaling pathways in cancer cells. |
| E3223 |
Alpiniae Officinarum Rhizoma Extract |
Alpiniae Officinarum Rhizoma Extract is extracted from Alpiniae Officinarum Rhizoma, which inhibits acetylcholinesterase (AChE) and can be used for the treatment of Alzheimer's disease. |
| E4926 |
Alprenolol |
Alprenolol ((RS)-Alprenolol; dl-Alprenolol) is an orally active non-selective β-adrenoceptor antagonist and an antagonist of 5-HT1A and 5-HT1B receptors. Alprenolol is used as an anti-hypertensive, anti-anginal and anti-arrhythmic agent. |
| S5802 |
Alprenolol hydrochloride |
Alprenolol hydrochloride is the hydrochloride salt form of alprenolol, which is an beta adrenergic receptorantagonist and is used as an antihypertensive, anti-anginal, and anti-arrhythmic agent. |
| S1508 |
Alprostadil (PGE1) |
Alprostadil (PGE1) is used as a drug in the treatment of erectile dysfunction and has vasodilatory properties. It is a Prostaglandin Analog and Prostaglandin E1 Agonist. |
| S5803 |
Alrestatin |
Alrestatin is an inhibitor of aldose reductase which is involved in the pathogenesis of complications of diabetes mellitus, including diabetic neuropathy. |
| S8546 |
Alrizomadlin |
Alrizomadlin(APG-115, AA-115) is a highly potent and efficacious inhibitor of MDM2 and binds to MDM2 with IC50 of 3.8 nM. It exhibits potent antiproliferative and apoptogenic activities and also significantly reduces tumor burden and prolonged survival in AML xenograft models. |
| S0354 |
Alsterpaullone |
Alsterpaullone (Alp, 9-Nitropaullone, NSC 705701) is a potent inhibitor of CDK with IC50 of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35, respectively. Alsterpaullone also acts as a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50 of both 4 nM for GSK-3α and GSK-3β. Alsterpaullone induces apoptosis by activation of caspase-9. Alsterpaullone has antitumor activity and possesses potential for the treatment of neurodegenerative and proliferative disorders. |
| E3655 |
Althaea rosea Extract(leaves) |
Althaea Rosea Extract(Leaves) is extracted from the leaves of Althaea Rosea. |
| E3654 |
Althaea rosea Extract(root) |
Althaea rosea Extract(root) is extracted from the root of Althaea rosea Extract, which can inhibit NF-κB. |
| S6412 |
Altiratinib |
Altiratinib (DCC-2701) is a potent single-digit nanomolar inhibitor of TRK, Met (c-Met), TIE2, and VEGFR2 kinases with IC50 vaules of 0.9 nM, 4.6 nM, and 0.8 nM for TRKA, B, and C, respectively. It inhibits Met (c-Met) and Met (c-Met) mutant with IC50 values in the range of 0.3-6 nM. |
| S3167 |
Altrenogest |
Altrenogest (A35957, RU2267,R2267) is a progestogen structurally related to veterinary steroid trenbolone. |
| S1278 |
Altretamine |
Altretamine (Hexamethylmelamine, NSC13875, ENT50852) is an anti-neoplastic agent. |
| S4826 |
Aluminium hydroxide |
Aluminium hydroxide (Aluminic), found in nature as the mineral gibbsite, is amphoteric (i.e., it has both basic and acidic properties). It is used to treat symptoms of increased stomach acid, such as heartburn, upset stomach, sour stomach, or acid indigestion; also reduce phosphate levels in people with certain kidney conditions. |
| E0179 |
Aluminum potassium sulfate |
Aluminum potassium sulfate (APS) and tannic acid (ALTA) sclerotherapy are often used to treat hemorrhoids. Aluminum potassium sulfate induces learning and memory deficits in mice. |
| S7218 |
Alvelestat (AZD9668) |
Alvelestat (AZD9668, Avelestat) is an oral, highly selective inhibitor of neutrophil elastase (NE) with IC50 and Ki of 12 nM and 9.4 nM, at least 600-fold more selective over other serine proteases.
Phase 2.
|
| S5945 |
Alverine |
Alverine is a smooth muscle relaxant. |
| S3054 |
Alverine Citrate |
Alverine citrate (NSC 35459) is a drug used for functional gastrointestinal disorders. Alverine citrate is a 5-HT1A receptor antagonist, with an IC50 of 101 nM. |
| E8209 |
Alvespimycin |
Alvespimycin (17-DMAG) is a potent inhibitor of Hsp90, binding to Hsp90 with an EC50 of 62 ± 29 nM. |
| S1142 |
Alvespimycin (17-DMAG) HCl |
Alvespimycin (17-DMAG, NSC 707545, BMS 826476, KOS 1022) HCl is a potent HSP90 inhibitor with IC50 of 62 nM in a cell-free assay. |
| S5935 |
Alvimopan |
Alvimopan (LY 246736, ADL 8-2698) is a potent, relatively nonselective opioid antagonist with Ki values of 0.77, 4.4, and 40 nM for the μ, δ, and κ opioid receptors, respectively, displaying >100-fold selectivity over other aminergic G-protein-coupled receptors. |
| S5701 |
Alvimopan dihydrate (LY246736 dihydrate) |
Alvimopan (LY-246736) is a potent, relatively nonselective opioid antagonist with Ki values of 0.77, 4.4, and 40 nM for the μ, δ, and κ opioid receptors, respectively, displaying >100-fold selectivity over other aminergic G-protein-coupled receptors. |
| S6515 |
ALW II-41-27 |
ALW II-41-27 (compound 7) is a potent inhibitor of Eph receptor tyrosine kinase with Kd of 12 nM for EphA2. |
| S6633 |
AM 095 |
AM095 is an antagonist of the LPA type 1 receptor with IC50 values of 0.98 and 0.73 μM for recombinant human and mouse LPA1, respectively. |
| E5883 |
AM-9022 |
AM-9022 is an orally active, potent, and selective inhibitor of KIF18A, a mitotic kinesin motor protein critical for chromosome alignment and segregation. It exhibits significant anti-cancer effects in human breast and ovarian tumor models. |
| E1481 |
AM-9747 |
AM-9747 (PRMT5-IN-25) is a potent inhibitor of PRMT5 with a Ki of 0.06 nM. It exhibits antiproliferative activity and a significant oral antitumor effect in mouse models employing patient-derived xenografts (PDX). |
| E7475 |
AM095 |
AM095 is a selective LPA1 receptor antagonist. The IC50 for AM095 antagonism of LPA-induced calcium flux of human or mouse LPA1-transfected CHO cells is 0.025 and 0.023 μM, respectively. |
| S1544 |
AM1241 |
AM-1241 is a selective cannabinoid CB2 receptor agonist with Ki of 3.4 nM, exhibits 82-fold selectivity over CB1 receptor. |
| S3527 |
AM2394 |
AM-2394 is a structurally distinct glucokinase activator (GKA), activates glucokinase (GK) with an EC50 of 60 nM. |
| S2819 |
AM251 |
AM251 block the inhibitory effects of endocannabinoids and synthetic cannabinoid agonists on transmitter release through an action at presynaptic cannabinoid 1 receptors in brain. |
| E8036 |
AM404 |
AM404, an inhibitor of endocannabinoid reuptake, blocks anandamide transport with IC50 values in the low micromolar range. AM404 is able to relax rat isolated hepatic arteries contracted with Phenylephrine, with a pEC50 value of 7.4 (corresponding to an EC50 of 0.04 µM). Neuroprotective Effect. |
| S2933 |
AM580 |
AM580 is a retinoic acid receptor agonist with Kd values of 8 nM, 131 nM and 450 nM for RARα, RARβ and RARγ. |
| S3534 |
AM966 |
AM966 is a high affinity, selective, oral Lysophosphatidic acid receptor 1 (LPA1) antagonist, which can inhibit LPA-stimulated intracellular calcium release (IC50=17 nM, by Ca flux assay). |
| S5499 |
Amantadine |
Amantadine (1-Adamantanamine) is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is an M2 inhibitor which blocks the ion channel formed by the M2 protein that spans the viral membrane.Amantadine can relieve muscle stiffness, tremors, and movement disorders caused by Parkinson's disease. |
| S2451 |
Amantadine HCl |
Amantadine HCl has antiviral and anti-parkinsonian activities and is used to treat or prevent respiratory infections caused by certain viruses. It is also widely used in the treatment of Parkinson's disease. |
| S1273 |
Amarogentin |
Amarogentin (AG), a secoiridoid glycoside mainly extracted from Swertia and Gentiana roots, exhibits anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin is an agonist for the bitter taste receptor TAS2R1 and inhibits in LAD-2 cells substance P-induced production of newly synthesized TNF-α. Amarogentin induces apoptosis in human gastric cancer cells (SNU-16) through G2/M cell cycle arrest and PI3K/Akt signalling pathway. Amarogentin (AG) interacts with the α2 subunit of AMP-activated protein kinase (AMPK) and activates the trimeric kinase with EC50 of 277 pM. |
| A5813 |
AMBP Rabbit Recombinant mAb |
AMBP Rabbit Recombinant mAb detects endogenous levels of total AMBP. |
| S2097 |
Ambrisentan |
Ambrisentan (LU-208075, BSF-208075) is a highly selective antagonist of the endothelin-1 type A receptor, used in the treatment of pulmonary arterial hypertension (PAH). |
| S5710 |
Ambroxol |
Ambroxol, a substituted benzylamine, is an active metabolite of bromhexine. It is a potent inhibitor of the neuronal Na+ channels. |
| S3064 |
Ambroxol HCl |
AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. Phase 3. |
| S8572 |
Amcasertib (BBI503) |
Amcasertib (BBI503), a first-in-class cancer stemness kinase inhibitor, is claimed to inhibit Nanog and other CSC pathways by targeting kinases with potential anticancer activity. |
| S9609 |
Amcenestrant (SAR439859) |
Amcenestrant (SAR439859, compound 43d) is an orally available and nonsteroidal selective estrogen receptor degrader (SERD) with potential antineoplastic activity. SAR439859 is a potent estrogen receptor (ER) antagonist with EC50 of 0.2 nM for ERα degradation. |
| S5671 |
Amcinonide |
Amcinonide (Cyclocort, CL-34699) is an inhibitor of nitric oxide (NO) release from activated microglia with IC50 of 3.38 nM. |
| S2879 |
AMD3465 hexahydrobromide |
AMD3465 is a monomacrocyclic CXCR4 antagonist. |
| S6584 |
Amdinocillin |
Amdinocillin (Mecillinam, Coactin, FL 1060) is a β-lactam antibiotic with a broad spectrum of antibacterial activity. Amdinocillin is active alone against many gram-negative organisms. |
| S5552 |
Amenamevir |
Amenamevir (ASP2151) is a potent helicase-primase inhibitor and a novel class of antiviral agent. |
| S3833 |
Amentoflavone |
Amentoflavone (Didemethyl Ginkgetin) is a biflavonoid originally isolated from Selaginella with antibacterial, antioxidant, antiviral, antidiabetic, and neuroprotective activities. |
| E8300 |
Amezalpat |
Amezalpat is a first-in-class, oral, competitive antagonist of peroxisome proliferator-activated receptor α (PPARα), with IC50 of 0.04 µM. It inhibits fatty acid oxidation (FAO), disrupting cancer cell metabolism and restoring immune responses, and shows antitumor activity in research on advanced solid tumors. |
| S6462 |
Amezinium (methylsulfate) |
Amezinium is a sympathomimetic used for its vasopressor effects in the treatment of hypotensive states. It is a MAO inhibitor, antagonizes the response to tyramine and blocks neuronal uptake of noradrenaline. |
| F2970 |
AMF Mouse mAb |
AMF,GPI |
| S2452 |
Amfebutamone (Bupropion) HCl |
Amfebutamone (Bupropion) HCl(Wellbutrin) is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4 μM for the reuptake of dopamine and norepinephrine, respectively. |
| S4149 |
Amfenac Sodium Monohydrate |
Amfenac Sodium monohydrate is a non-steroidal analgesic anti-inflammatory drug with acetic acid moiety. The IC50 values for COX1 and COX2 is 250 nM and 150 nM, respectively. |
| S7426 |
AMG 232 ( KRT-232 ) |
AMG 232 (Navtemadlin) is a potential, selective inhibitor of the MDM2–p53 interaction, with an IC50 of 0.6 nM and binds to MDM2 with a Kd of 0.045 nM. It also demonstrated antitumor activity in vivo in a variety of tumor types with different genetic backgrounds. |
| S8167 |
AMG 337 |
AMG 337 is an oral, small molecule, ATP-competitive, highly selective inhibitor of the Met (c-Met) receptor with an IC50 of 1 nM. |
| E6406 |
AMG 410 |
AMG410 is a non-covalent, selective inhibitor of pan-KRAS with IC50 of 1–4 nM for KRAS G12D, G12V, and G13D. It binds both GDP- and GTP-bound KRAS with Kd of 1 nM and 22 nM, respectively. AMG410 inhibits KRAS signaling in a nucleotide cycling-independent manner. It also suppresses proliferation in KRAS-amplified wild-type tumor cells. |
| S8682 |
AMG 487 |
AMG 487 is an orally active and selective CXC chemokine receptor 3 (CXCR3) antagonist that inhibits the binding of IP-10 (CXCL10) and ITAC (CXCL11) to CXCR3 with IC50 of 8.0 nM and 8.2 nM, respectively. |
| E1761 |
AMG PERK 44 |
AMG PERK 44 is a highly selective and orally active inhibitor of PERK with an IC50 of 6 nM. AMG PERK 44 exhibits 1000-fold and 160-fold selectivity over GCN2 and B-Raf, respectively. |
| S0361 |
AMG-1 |
AMG-1 (c-Met/RON Dual Kinase Inhibitor, RON-IN-1) is a potent inhibitor of human c-Met and RON with IC50 of 4 nM and 9 nM, respectively. |
| E1600 |
AMG-193 |
AMG-193 is an orally active and MTA-cooperative inhibitor of PRMT5 with potent biochemical and cellular activity. AMG-193, in combination with MTA, selectively targets and inhibits the growth of MTAP-deficient tumor cells by suppressing PRMT5, with an IC50 of 0.107 μM, while sparing normal cells that possess wild-type MTAP. AMG-193 also exhibits antitumor activity. |
| S1316 |
AMG-208 |
AMG 208 is a highly selective dual c-Met and RON inhibitor with IC50 of 9 nM for c-Met. |
| S6638 |
AMG-333 |
AMG-333 is a potent and highly selective antagonist of TRPM8 with IC50 values of 13 nM and 30 nM for human TRPM8 and rat TRPM8. |
| E7729 |
AMG-3969 |
AMG-3969 is a potent glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor with an IC50 of 4 nM. |
| S2747 |
AMG-458 |
AMG 458 is a potent c-Met inhibitor with Ki of 1.2 nM, ~350-fold selectivity for c-Met than VEGFR2 in cells. |
| S2213 |
AMG-47a |
AMG-47a is a potent, nonselective inhibitor of Lck kinase with IC50 of 3.4 uM and it also inhibits T cell proliferation. AMG-47a exhibit anti-inflammatory activity (ED50) of 11 mg/kg in the anti-CD3-induced production of interleukin-2 (IL-2) in mice. |
| S7115 |
AMG-517 |
AMG 517 is a potent and selective TRPV1 antagonist, and antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM， respectively. |
| S2719 |
AMG-900 |
AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM. It is >10-fold selective for Aurora kinases than p38α, Tyk2, JNK2, Met and Tie2. Phase 1. |
| S6934 |
AMG-9810 |
AMG-9810 is a potent, competitive and selective vanilloid receptor 1 (TRPV1) antagonist and inhibits capsaicin activation with IC50 of 24.5 nM and 85.6 nM for human TRPV1 and rat TRPV1, repectively. AMG-9810 blocks all known modes of TRPV1 activation, including protons-, heat-, and endogenous ligands, such as anandamide, N-arachidonyl dopamine, and oleoyldopamine. AMG-9810 significantly reduces the mRNA expression of TLR2 and TLR4. AMG-9810 also promotes mouse skin tumorigenesis mediated through EGFR/Akt/mTOR signaling. |
| S7813 |
AMG319 |
AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.
|
| S5445 |
AMI-1 (free acid) |
AMI-1 is a potent and specific Histone Methyltransferase (HMT) inhibitor with IC50 of 3.0 μM and 8.8 μM for yeast Hmt1p and human PRMT1, respectively. |
| E8201 |
Amifostine |
Amifostine (WR2721) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine protects cells from damage by scavenging oxygen-derived free radicals. Amifostine reduces renal toxicity and has antiangiogenic action. |
| S4298 |
Amifostine trihydrate |
Amifostine trihydrate(WR2721 trihydrate) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin. |
| E4932 |
Amikacin |
Amikacin(BAY 41-6551, Lukadin) is a semisynthetic aminoglycoside, derived from kanamycin-A, that acts as an inhibitor of the Z ring formation, leading to the inhibition of cell division. It is used to treat serious infections caused by aerobic Gram-negative bacteria, mycobacteria, Nocardia, and life-threatening infections in neonates. |
| S3065 |
Amikacin disulfate |
Amikacin sulfate (BB-K8) binds to 16S rRNA (bacterial 30S ribosome), causing misreading of mRNA and supressing proteins synthesis. |
| S3122 |
Amikacin hydrate |
Amikacin(BAY416651 hydrate) is an aminoglycoside antibiotic used to treat different types of bacterial infections. |
| S5330 |
Amikacin Sulfate Salt |
Amikacin (BAY 41-6551) sulfate, a semisynthetic analog of kanamycin, is an aminoglycoside antibiotic which is very active against most gram-negative bacteria including gentamicin- and tobramycin-resistant strains. |
| E8150 |
Amiloride |
Amiloride (MK-870) is the first potent inhibitor of epithelial sodium channel (ENaC), inhibiting δβγ ENaC with an IC50 of 2.6 μM. It is also a typical blocker of PC2(TRPP2) channels and can be used in the research to study Autosomal dominant polycystic kidney disease (ADPKD). |
| S1811 |
Amiloride HCl |
Amiloride HCl is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA)(Ki=7 μM). |
| S2560 |
Amiloride HCl dihydrate |
Amiloride HCl dihydrate(MK-870 hydrochloride dihydrate) is a potent epithelial sodium channel (ENaC) blocker, used in the management of hypertension and congestive heart failure. |
| S3218 |
Amiloxate |
Amiloxate (Amiloxiate, Isoamyl Methoxycinnamate, Isopentyl 4-methoxycinnamate, Isoamyl 4-methoxycinnamate, Isoamyl p-methoxycinnamate, Isopentyl p-methoxycinnamate) is EMA-approved chemical UV-filter used in cosmetics. Amiloxate is a cinnamic acid derivative with anti-inflammatory activity. |
| E7296 |
Amine-PEG3-Biotin |
Amine-PEG3-Biotin is a signal amplification label containing a biotin group and a terminal primary amine group. |
| S1872 |
Amino-PEG1-C2-acid |
Amino-PEG1-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
| S4548 |
Aminoguanidine hydrochloride |
Aminoguanidine (Pimagedine, Guanyl hydrazine, Hydrazinecarboximidamide, Imino semicarbazide, Monoaminoguanidine) is a diamine oxidase and nitric oxide synthase inhibitor. It acts to reduce levels of advanced glycation end products (AGEs) through interacting with 3-deoxyglucosone. |
| S6129 |
Aminomalonic acid |
Aminomalonic acid (Aminomalonate, Aminopropanedioic acid) is an amino dicarboxylic acid. It has a role as a human metabolite and a Daphnia magna metabolite. |
| S1673 |
Aminophylline |
Aminophylline (Phyllocontin) is a competitive nonselective phosphodiesterase inhibitor with an IC50 of 0.12 mM and also a nonselective adenosine receptor antagonist. |
| E1003 |
Aminopterin |
Aminopterin (4-amino Folic Acid, 4-amino PGA, 4-Aminofolic acid, 4-Aminopteroylglutamic acid, Aminopteroylglutamic acid, APGA, NSC 739), a folic acid antagonist, is a competitive inhibitor of dihydrofolate reductase (DHFR) with Ki of 3.7 pM. |
| S0734 |
Aminopurvalanol A |
Aminopurvalanol A, a selective,cell permeable and competitive inhibitor of cyclins/Cdk complexes, causes the reduction of in vitro fertilizing ability of boar spermatozoa, by negatively affecting the capacitation-dependent actin polymerization. |
| S4198 |
Aminothiazole |
Aminothiazole(2-Aminothiazole,2-Thiazolylamine) can be used as a thyroid inhibitor and it has antibacterial activity. |
| E7024 |
Amiodarone |
Amiodarone is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM. |
| S1979 |
Amiodarone HCl |
Amiodarone HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias. |
| S1280 |
Amisulpride |
Amisulpride (DAN-2163) is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder. |
| S3643 |
Amitraz |
Amitraz (NSC 324552) is a triazapentadiene, an α2 adrenergic agonist and a member of the amidine chemical family. It is a non-systemic acaricide and insecticide. |
| S5947 |
Amitriptyline |
Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties, widely used to treat depression and neuropathic pain. Amitriptyline is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline also inhibits histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. This product is a waxy solid. |
| S3183 |
Amitriptyline HCl |
Amitriptyline HCl is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline HCl also inhibits histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. Amitriptyline is a tricyclic antidepressant (TCA). |
| A4000 |
Amivantamab (Anti-cMet & EGFR) |
Amivantamab is a fully human bispecific antibody that targets both epidermal growth factor receptor (EGFR) and mesenchymal-epithelial transition factor (MET). It exhibits immune anticancer activity in non-small cell lung cancer (NSCLC). MW :145.88 KD. |
| A2601 |
Amivantamab (Anti-HGFR / c-Met) |
Amivantamab (Anti-HGFR/c-Met) is an antibody targeting hepatocyte growth factor receptor (HGFR, also known as c-Met) with immunohistochemical activity against non-small cell lung cancer (NSCLC). MW: 145.88KD. |
| F0537 |
AML1 Rabbit mAb |
AML1,RUNX1,RUNX1 / AML1 |
| E3117 |
Amla Extract |
Amla Extract is extracted from the fruit of Emblica officinalis, which is efficacious against diversified ailments like inflammation, cancer, osteoporosis, neurological disorders, hypertension, together with lifestyle diseases, parasitic and other infectious disorders. |
| S3648 |
Amlexanox |
Amlexanox is an anti-inflammatory antiallergic immunomodulator and also an inhibitor of the protein kinases TBK1 and IKK-ε. |
| S1905 |
Amlodipine |
Amlodipine (UK-48340) is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain. |
| S1813 |
Amlodipine Besylate |
Amlodipine Besylate is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain. |
| S5966 |
Amlodipine maleate |
Amlodipine (Amvaz, UK-48340) maleate is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain. |
| E7311 |
Ammonium bicarbonate,AR,99% |
Ammonium bicarbonate is a bioactive chemical. |
| E0375 |
Ammonium ferric citrate |
Ammonium ferric citrate (Ferric ammonium citrate, Ammonium iron(III) citrate, Iron ammonium citrate, FerriSeltz) induces ferroptosis in non-small-cell lung carcinoma through the inhibition of GPX4-GSS/GSR-GGT axis activity. |
| S6262 |
Ammonium formate |
Ammonium Formate is the ammonium salt of formic acid. It is widely used in various organic reactions. |
| S9143 |
Ammonium Glycyrrhizate |
Ammonium glycyrrhizate (Glycamil, Glycyrram) is an ammonium salt extract isolated from licorice root and is commonly used as a flavoring agent and is also used in fragrances, and skin and hair care products. |
| S2376 |
Ammonium Glycyrrhizinate |
Ammonium Glycyrrhizinate (AMGZ, Glycyram, Glycyrrhizin ammonium salt, Glycyrrhizic acid ammonium salt) is a unique product from Licorice root with a very high sweetness. Ammonium glycyrrhizinate is a direct inhibitor of HMGB1 with anti-inflammatory, anti-tumor, anti-diabetic activities. Ammonium Glycyrrhizinate inhibits growth and cytopathology of several unrelated DNA and RNA viruses. Ammonium Glycyrrhizinate also inhibits both hepatic delta 4-5-reductase and 11 beta-hydroxysteroid dehydrogenase. |
| S5625 |
Ammonium lactate |
Ammonium lactate (Lac-hydrin) is the ammonium salt of lactic acid with mild anti-bacterial properties. |
| E4018 |
Ammonium sulfate |
Ammonium sulphate (Mascagnite) is an inorganic sulfate salt used for the purification of enzymes and antibodies. |
| E4721 |
Ammonium tetrathiomolybdate |
Ammonium tetrathiomolybdate is a potent copper chelator and an effective inorganic H₂S donor. It exhibits H₂S-like cytoprotective effects and is used therapeutically for copper toxicosis, particularly in Wilson’s disease and also in amyotrophic lateral sclerosis (ALS). |
| S5948 |
Amodiaquine |
Amodiaquine is a synthetic aminoquinoline that acts by binding to the protozoal or parasitic DNA and preventing DNA and RNA production and subsequent protein synthesis. It is used for the therapy of malaria. |
| S4589 |
Amodiaquine dihydrochloride dihydrate |
Amodiaquine is a potent, non-competitive inhibitor of histamine N-methyl transferase with estimated Ki of 18.6 nM. It is also used as an antimalarial and anti-inflammatory agent. |
| S5500 |
Amodiaquine hydrochloride |
Amodiaquine Hydrochloride is the hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties. |
| E3762 |
Amomum Extract |
Amomum Extract is derived from the fruit or seed of the ginger plant, which has high medicinal value. |
| E3015 |
Amomum Kravanh Extract |
Amomum Kravanh Seed Extract is extracted from the seed of Amomum Kravanh, which has antioxidant, DNA damage protective, antibacterial activities and nitrite scavenging ability. |
| E3167 |
Amomum Kravanh Fruit Extract |
Amomum Kravanh Fruit Extract is obtained from the fruits of Amomum kravanh Pierre ex Gagnep, of which the essential oil has significant antioxidant activity, the protective effect against DNA damage, and nitrite scavenging activity. |
| E3610 |
Amomum villosum Extract |
Amomum Villosum Extract is extracted from Amomum villosum Lour., a herbaceous plant in the ginger family. Amomum villosum has been proven to be effective in treating gastrointestinal diseases. Treatment with Amomum villosum water extract significantly attenuates intestinal inflammation in inflammatory bowel disease (IBD) rats. |
| S1367 |
Amonafide |
Amonafide (NSC308847, AS1413) produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage. Phase 3. |
| S1676 |
Amorolfine HCl |
Amorolfine HCl(Ro 14-4767 HCl) is an antifungal reagent. |
| S4218 |
Amoxapine |
Amoxapine (CL 67772,Asendin) is a tricyclic dibenzoxazepine (an N-aryl piperazine) which acts similarly to several other tricyclic antidepressants, amoxapine inhibits GLYT2a transport activity with IC50 of 92 μM. |
| S3015 |
Amoxicillin |
Amoxicillin (Amoxycillin) is a moderate-spectrum, bacteriolytic, β-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. |
| S2565 |
Amoxicillin Sodium |
Amoxicillin Sodium (Clavulanate,Amoxycillin sodium) is a moderate- spectrum, bacteriolytic, β-lactam antibiotic. |
| S5298 |
Amoxicillin trihydrate |
Amoxicillin (Amoxil, Amoxipen, Moxaline) is a broad-spectrum, semisynthetic aminopenicillin antibiotic with bactericidal activity. |
| F0668 |
AMPA Receptor 1 (GluA1) Rabbit mAb |
AMPA Receptor 1 (GluA1),GluR1,GluR-1,Glutamate receptor 1,Glutamate Receptor 1 (AMPA subtype) |
| F1223 |
AMPA Receptor 2 (GluA2) Rabbit mAb |
AMPA Receptor 2 (GluA2),GluA2/GluR2 glutamate receptor,GluR2,Glutamate Receptor 2,Ionotropic Glutamate receptor 2 |
| F1270 |
AMPA Receptor 3 (GluA 3) Rabbit mAb |
AMPA Receptor 3 (GluA 3),AMPA Receptor 3 (GluA3),Glutamate Receptor 3,Glutamate receptor 3/GluA3 |
| F1450 |
AMPA Receptor 4 (GluA 4) Rabbit mAb |
AMPA Receptor 4 (GluA 4),Glutamate Receptor 4 |
| S0165 |
Ampalex (CX-516) |
Ampalex (CX-516, Ampakine CX 516, BDP-12, SPD 420) is a positive allosteric modulator of AMPA receptor. Ampalex exhibits potential treatment for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI). |
| E3685 |
Ampelopsis grossedentata Extract |
Ampelopsis Grossedentata Extract is extracted from Ampelopsis Grossedentata, which can induce apoptosis in cancer cells. |
| E3024 |
Ampelopsis Japonica Root Extract |
Ampelopsis Japonica Root Extract is extracted from Ampelopsis japonica, may be a new therapeutic agent with the potential to reduce or replace corticosteroids and its mechanisms are closely related to regulation of TNF-α production. |
| S1636 |
Amphotericin B |
Amphotericin B (AMB, NSC 527017) is an amphipathic polyene antibiotic which permeabilizes ergosterol-containing membranes. |
| E4353 |
Ampicillin |
Ampicillin (D-(-)-alpha-Aminobenzylpenicillin) is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria. It exhibits a good minimum inhibitory concentration for Staphylococcus aureus, Escherichia coli, Hemophilus influenzae, and Streptococcus pneumoniae with MICs of 0.6–1 mg/L, 4 mg/L, 0.25 mg/L, and 0.03-0.06 mg/L, respectively. |
| S3170 |
Ampicillin sodium |
Ampicillin(D-(-)-α-Aminobenzylpenicillin sodium salt) is a beta-lactam antibiotic that is part of the aminopenicillin family. |
| S4148 |
Ampicillin Trihydrate |
Ampicillin Trihydrate (NCI-C56086,D-(-)-α-Aminobenzylpenicillin trihydrate) is a β-lactam antibiotic, which inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidases on the inner surface of the bacterial cell membrane. |
| S4011 |
Ampiroxicam |
Ampiroxicam (CP 65703) is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug. |
| A5025 |
AMPK gamma 1 Rabbit Recombinant mAb |
AMPK gamma 1 Rabbit Recombinant mAb detects endogenous levels of AMPK gamma 1.
|
| F2859 |
AMPK α1 Rabbit mAb |
|
| F2393 |
AMPK α2 Rabbit mAb |
AMPK alpha 2,AMPKα2 |
| F1072 |
AMPK β1 Rabbit mAb |
AMPK beta 1,AMPKβ1 |
| E7616 |
Ampkinone |
Ampkinone is an indirect AMP-activated protein kinase (AMPK) activator. |
| F0269 |
AMPKα Rabbit mAb |
5'-AMP-activated protein kinase catalytic subunit alpha-1, AMPK subunit alpha-1, Acetyl-CoA carboxylase kinase, ACACA kinase, Hydroxymethylglutaryl-CoA reductase kinase, HMGCR kinase, Tau-protein kinase PRKAA1, PRKAA1, AMPK1, 5'-AMP-activated protein kinase catalytic subunit alpha-2, AMPK subunit alpha-2, PRKAA2, AMPK2 |
| F0371 |
AMPKβ1/2 Rabbit mAb |
5'-AMP-activated protein kinase subunit beta-1, AMPK beta-1, AMPK β-1, AMPKb, AMPK beta-2, AMPK β-2, PRKAB1, AMPK, PRKAB2, AMPK subunit beta-1, 5'-AMP-activated protein kinase subunit beta-2, AMPK subunit beta-2 |
| S1639 |
Amprenavir (VX-478) |
Amprenavir (VX-478, 141W94, KVX-478) is a potent PXR-selective agonist, and an HIV protease inhibitor, used to treat HIV. |
| S3171 |
Amprolium |
Amprolium(Amprol), an anticoccidial drug, is an antagonist of thiamine (vitamin B1) that significantly affects thiamine transport and utilization in cells. |
| S4144 |
Amprolium HCl |
Amprolium chloride is a thiamin antagonist, which prevents carbohydrate synthesis by blocking thiamine uptake. |
| E4609 |
Amredobresib |
Amredobresib (BI894999) is an oral inhibitor of BET, which acts as an acetyl-lysine mimic. It prevents the bromodomains BRD4-BD1 and BRD4-BD2 from binding to acetylated histones, with an IC50 of 5 nM for BRD4-BD1 and 41 nM for BRD4-BD2. |
| E4925 |
Amsacrine |
Amsacrine(m-AMSA; acridinyl anisidide) is an inhibitor of topoisomerase II. Amsacrine acts as an antineoplastic agent which intercalates into the DNA of tumor cells, it is also used in the treatment of acute myelogenous leukemia. |
| S5627 |
Amsacrine hydrochloride |
Amsacrine hydrochloride (m-AMSA, acridinyl anisidide) is the hydrochloride salt form of amsacrine, which is an inhibitor of topoisomerase II with antineoplastic activity. |
| E4673 |
AMTB hydrochloride |
AMTB hydrochloride is a blocker of the transient receptor potential melastatin 8 (TRPM8) ion channel. It reduces the activation of TRPM8 channels induced by icilin, as assessed through a Ca2+ influx assay, with a pIC50 of 6.23. It is used as a tool to evaluate the role of this channel in bladder rhythmic contraction. |
| S1244 |
Amuvatinib (MP-470) |
Amuvatinib (MP-470, HPK 56) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively. Amuvatinib suppresses c-MET and c-RET. Amuvatinib is also active as a DNA repair protein Rad51 inhibitor with antineoplastic activity. Phase 2. |
| S2260 |
Amygdalin |
Amygdalin is a glycoside initially isolated from the seeds of the tree Prunus dulcis, also known as bitter almonds. |
| S6173 |
Amylmetacresol |
Amylmetacresol is an antiseptic used to treat infections of the mouth and throat. |
| A5317 |
Amyloid beta A4 Rabbit Recombinant mAb |
Amyloid beta A4 Rabbit Recombinant mAb detects endogenous level of total Amyloid beta A4. |
| F2535 |
Amyloid Precursor Protein Rabbit mAb |
Amyloid Precursor Protein,Amyloid Precursor Protein, C-Terminal,APP,APP A4,APP/β-Amyloid |
| S0308 |
AMZ30 |
AMZ30 (ML136, CS-2122) is a selective and covalent inhibitor of protein phosphatase methylesterase-1(PME-1) with IC50 of 0.60 μM. AMZ30 reduces the demethylated form of PP2A in living cells. |
| S3532 |
AN-2718 |
AN-2718, an inhibitor of fungal growth that blocks protein synthesis via the oxaborole tRNA trapping (OBORT) mechanism. |
| S7582 |
Anacardic Acid |
Anacardic Acid (6-pentadecylsalicylic Acid) is a potent inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases, which also has antibacterial activity, antimicrobial activity,
prostaglandin synthase inhibition, and tyrosinase and lipoxygenase inhibition.
|
| S2748 |
Anacetrapib (MK-0859) |
Anacetrapib (MK0859) is a potent, selective, reversible rhCETP and mutant CETP(C13S) inhibitor with IC50 of 7.9 nM and 11.8 nM, increases HDL-C and decreases LDL-C, does not increase aldosterone or blood pressure. Phase 3. |
| S5909 |
Anagliptin |
Anagliptin is an orally active and highly selective dipeptidyl peptidase-4 (DPP-4) inhibitor and exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation. |
| E4924 |
Anagrelide |
Anagrelide(BL416201), an imidazoquinazoline derivative, is an inhibitor of phosphodiesterase type III (PDEIII) with IC50 of 36 nM, which acts as an antithrombotic and platelet-reducing agent. |
| S3172 |
Anagrelide HCl |
Anagrelide (BL-4162A,BMY 26538-01) is a drug used for the treatment of essential thrombocytosis. |
| S4980 |
Anamorelin |
Anamorelin (ONO-7643, RC-1291, ST-1291) is an orally active, high-affinity, selective agonist of the ghrelin receptor with an EC50 value of 0.74 nM in the HEK293/GRLN FLIPR assay. |
| E4923 |
AnaMorelin hydrochloride |
Anamorelin hydrochloride(RC-1291 HCL, ONO-7643) is a potent and selective agonist of ghrelin receptor with EC50 of 0.74 nM FLIPR assay. It has a significant appetite-enhancing activity and has the potential to treat cancer anorexia-cachexia syndrome. |
| S1188 |
Anastrozole |
Anastrozole is a third-generation nonsteroidal selective aromatase inhibitor. It may offer greater selectivity compared with other aromatase inhibitors, being without any intrinsic endocrine effects and with no apparent effect on the synthesis of adrenal steroids. |
| S0295 |
Anavex 2-73 HCl |
Anavex 2-73 (Blarcamesine, AVex-73, AE-37), an aminotetrahydrofuran derivative, is a mixed muscarinic and sigma-1/σ1 Receptor agonist with IC50 of 0.86 μM. |
| F3234 |
Androgen Receptor (M23G3) Rabbit mAb |
|
| F0220 |
Androgen Receptor Rabbit mAb |
|
| E5189 |
Andrograpanin |
Andrograpanin, a bioactive compound from Andrographis paniculata, exhibits anti-inflammatory and anti-infectious properties. |
| E3107 |
Andrographis Herba Extract |
Andrographis Herba Extract is obtained from the aerial part of Andrographis paniculata (Burm. F.) Nees, has various activities including antimicrobial and antioxidant, antimalarial, antiangiogenic, anti-inflammatory, anti-diabetic, and in vitro α-glucosidase and α-amylase enzyme inhibitory activities. |
| S2261 |
Andrographolide |
Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata. |
| E3869 |
Anemarrhena Extract |
Anemarrhena Extract is extracted from Anemarrhena rhizome, which helps to increase cell proliferation and neuropeptide Y expression in the hippocampal dentate gyrus. |
| E5723 |
Anemarrhenasaponin I |
Anemarrhenasaponin I, a traditional Chinese medicine, shows remarkable inhibiting effect on platelet aggregation. |
| S9081 |
Anemoside B4 |
Anemoside B4 (Pulchinenoside B4, Chinensioside A, Pulchinenoside C, Pulsatilla saponin B4), extracted from the herb of Pulsatilla chinensis (Bge.) Regel, is a potential antiviral constituent and inhibits the secretion of IL-10. |
| S4744 |
Anethole trithione |
Anethole trithione is a drug used in the treatment of dry mouth. |
| D4011 |
Anetumab ravtansine |
Anetumab ravtansine (BAY 94-9343) is an antibody-drug conjugate (ADC) composed of a human anti-mesothelin antibody and a cytotoxic maytansinoid tubulin inhibitor DM4. Anetumab ravtansine has the potential to treat advanced solid tumors. |
| D4006 |
Anetumab-MMAE |
Anetumab-MMAE is an antibody-drug conjugate (ADC) composed of a human anti-mesothelin (MSLN) antibody and the anti-mitotic cytotoxic agent monomethyl auristatin (MMAE). |
| S3803 |
Angelic acid |
Angelic acid ((Z)-2-Methylbut-2-enoic acid) is a monocarboxylic unsaturated organic acid that is mostly found in the plants of the family Apiaceae. |
| S3806 |
Angelic anhydride |
Angelic anhydride (2-Methylisocrotonic Anhydride, (Z)-2-Methylbut-2-enoic anhydride) is a synthetic chemical and usually used in content determination assays and pharmacological experiments. |
| E3039 |
Angelica Root Extract |
Angelica Root Extract is extracted from the root of Angelica dahurica. |
| E3139 |
Angelica Sinensis Extract |
Angelica Sinensis Extract is extracted from the dried root of Angelica Sinensis (Radix Angelica Sinensis), of which the effects on cerebral infarction are through multiple pathways, including anti-arthrosclerosis, improving microcirculation, anti-platelet aggregation, anti-inflammatory and anti-oxidative effects. |
| E3169 |
Angelicae Pubescentis Radix Extract |
Angelicae Pubescentis Radix Extract is extracted from the dried roots of Angelica biserrata, which is an antirheumatic and analgesic agent included in Chinese Pharmacopoeia, and commonly treat rheumatic arthralgia and headache. |
| E8006 |
Angeloylgomisin O |
Angeloylgomisin O, a lignin extract of Schisandra rubriflora. Anti-inflammatory properties. |
| L5200 |
Angiogenesis Related compound Library |
A unique collection of 404 small molecules used for angiogenesis research targeting Bcr-Abl,BTK,HIF,VEGFR,FGFR,FAK,etc. |
| F2487 |
Angiopoietin 1 Rabbit mAb |
|
| F2164 |
Angiopoietin 2/ANG2 Rabbit mAb |
Angiopoietin 2/ANG2,Angiopoietin 2/Ang-2/ANGPT2,Angiopoietin-2 |
| S9820 |
Angiotensin (1-7) |
Angiotensin (1-7) (Ang-(1-7), Angiotensin fragment 1-7) is a bioactive component of the renin-angiotensin system that is formed endogenously from either Ang I or Ang II. Angiotensin (1-7) is a canine ACE inhibitor with an IC50 of 0.65 μM and inhibits the activity mediated by myostatin through Mas receptor. |
| F2456 |
Angiotensin Converting Enzyme 1 Rabbit mAb |
|
| E6076 |
Angiotensin I/II (5-8) |
Angiotensin II (5-8) is the smallest angiotensin peptide with a potent and selective antinociceptive effect, acting via neuronal-nitric oxide(NO) synthase-soluble guanylyl cyclase (sGC)-endogenous opioid pathway in the ventrolateral periaqueductal gray matter (vlPAG). It may hold potential for research in metabolic disorders, obesity, and Alzheimer’s disease. |
| E1015 |
Angiotensin II human |
Angiotensin II human is a potent vasoconstrictor that induces angiogenesis by activating angiotensin II type 1 (AT1) receptor, which increases the production of vascular endothelial growth factor (VEGF) in a redox-sensitive manner and promotes the formation of capillaries from endothelial cells through the LOX-1-dependent redox-sensitive pathway. |
| P1085 |
Angiotensin II human Acetate |
Angiotensin II (angII) is an octapeptide hormone which affects the activities of heart, kidney, vasculature and brain. It works via binding to specific receptors present on cell membranes. |
| E4975 |
Angiotensin II human TFA |
Angiotensin II human TFA(DRVYIHPF TFA, Ang II TFA) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system that regulates blood pressure by activating AT1Rand AT2R, stimulating sympathetic activity, aldosterone production, and renal actions. It also promotes vascular cell growth, collagen synthesis, fibrosis, and induces apoptosis and capillary formation via a redox-sensitive pathway. |
| F2225 |
Angiotensin II Type 2 Receptor Rabbit mAb |
AGTR-2,Angiotensin II Type 2 Receptor |
| E5594 |
Angoline |
Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation. |
| P1161 |
Angstrom6 |
Angstrom6 (A6 Peptide) is a capped, eight l-amino acid peptide (Ac-KPSSPPEE-NH2) derived from the biologically active connecting peptide domain of the serine protease, human urokinase plasminogen activator (uPA), which can binds to CD44 resulting in the inhibition of migration, invasion, and metastasis of tumor cells, and the modulation of CD44-mediated cell signaling. |
| E7670 |
Anguizole |
Anguizole is a small molecule inhibitor of HCV replication and alters NS4B's subcellular distribution.IC50 Value: Target: HCV |
| S9080 |
Anhydroicaritin |
Anhydroicaritin (Cycloicaritin), a prenylated flavonoid natural product, is commonly recognized as one of the effective compounds of Epimedii Herba and exhibits a variety of biological activities, such as activation of cancer cell apoptosis and inhibition of growth, protection against beta amyloid-induced neurotoxicity, and promotion of neuronal and cardiac cellular differentiation. It is a potent inhibitor of transcription factor SREBPs. |
| S4286 |
Anidulafungin |
Anidulafungin, an echinocandin derivative, inhibits glucan synthase activity, used as an antifungal drug.
|
| S1281 |
Aniracetam |
Aniracetam (RO 13-5057) is a nootropics and neuroprotective drug. |
| S9560 |
Anisodamine Hydrobromide |
Anisodamine (6-Hydroxyhyoscyamine) is a naturally occurring atropine derivative and exhibits anti-inflammatory activity. It also inhibits α1-adrenergic receptors and muscarinic acetylcholine receptors (mAChRs). |
| S7409 |
Anisomycin |
Anisomycin (Flagecidin, Wuningmeisu C) is a bacterial antibiotic isolated from Streptomyces griseolus, which inhibits protein synthesis, and also act as a JNK activator. Anisomycin upregulates autophagy and increases apoptosis. |
| S6782 |
Anle138b |
Anle138b is a novel oligomer modulator and an aggregation inhibitor, blocking the formation of pathological aggregates of prion protein (PrP(Sc)) and of α-synuclein (α-syn) with good oral bioavailability, blood-brain-barrier penetration and no detectable toxicity. Anle138b shows a new approach for disease-modifying therapy in neurodegenerative diseases such as prion and Parkinson's disease. |
| F0876 |
Annexin A1 Rabbit mAb |
Annexin A1,Annexin A1/ANXA1,Annexin I |
| A5338 |
Annexin A10 Rabbit Recombinant mAb |
Annexin A10 Rabbit Recombinant mAb detects endogenous level of total annexin A10. |
| F0621 |
Annexin A2 Rabbit mAb |
Annexin A2,Annexin-2/ANXA2 |
| F2106 |
Annexin V/ANXA5 Mouse mAb |
Annexin V,Annexin V/ANXA5 |
| E3181 |
Anona Squamosa Leaf Extract |
Anona Squamosa Leaf Extract is extracted from the leaf of Anona Squamosa, which has anticancer activities against cervical cancer. |
| A5935 |
ANP Rabbit Recombinant mAb |
ANP Rabbit Recombinant mAb detects endogenous levels of total ANP. |
| A2665 |
Anrukinzumab (Anti-IL-13) |
Anrukinzumab (Anti-IL-13) is a humanized monoclonal antibody targeting IL-13. It reduces lung inflammation and can be used in studies of ulcerative colitis (UC) as well as asthma. MW :150 KD. |
| S2447 |
Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222) |
Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222, Antibiotic C 15003P3) is a potent inhibitor of tubulin polymerization with IC50 of 3.4 μM. |
| S6141 |
Anserine |
Anserine (β-alanyl-N-methylhistidine) is a dipeptide containing β-alanine and 1-methylhistidine. It is normally absent from human tissues and body fluids, and its appearance there is an artifact of diet and serum carnosinase deficiency. |
| S0318 |
Ansofaxine hydrochloride |
Ansofaxine hydrochloride (LY03005, LPM570065), a triple reuptake inhibitor, inhibits serotonin, dopamine and norepinephrine reuptake with IC50 values of 723, 491 and 763 nM, respectively. |
| F0931 |
ANT2/SLC25A5 Rabbit mAb |
ANT2/SLC25A5,SLC25A5 |
| S4199 |
Antazoline HCl |
Antazoline hydrochloride(Phenazoline hydrochloride) is a first-generation antihistamine with anticholinergic properties and is commonly used to relieve nasal congestion and in eye drops. Antazoline hydrochloride exhibits a significant inhibitory effect on HBV DNA in the Huh7 cells, with an EC50 of 2.349 μmol/L. |
| E0164 |
Antazoline Phosphate |
Antazoline Phosphate is the phosphate salt of antazoline. Antazoline is a first-generation antihistaminic agent and acts as a histamine H1 receptor antagonist.
|
| F2604 |
Anterior Gradient 2 Rabbit mAb |
AG-2/AGR2,AGR2,Anterior Gradient 2 |
| S5168 |
Anthraquinone |
Anthraquinones (Anthradione, anthracenedione, dioxoanthracene) are the main active constituents in herbs often used to relieve constipation. |
| S9359 |
Anthraquinone-2-carboxylic Acid |
Anthraquinone-2-carboxylic Acid is a novel electron shuttling mediator, showing potent anti-inflammatory and antinociceptive activities in vivo. |
| E7231 |
Anthrone |
Anthrone is an organic compound commonly used as a dye and intermediate. It can be used to make products such as pigments, dyes and fluorescent whitening agents, and is widely used in certain industrial production fields such as textile manufacturing, soap making and paper making. In addition, this compound is also used as a reagent and catalyst in some organic synthesis reactions. |
| A2739 |
Anti-158P1D7 |
Anti-158P1D7 is a monoclonal anti-158P1D7 antibody used in the production of antibody drug conjugates (adc) that bind to 158P1D7 proteins. MW: 146.0 KD. |
| A2792 |
Anti-ABCB5 |
Anti-ABCB5 is a monoclonal antibody (mAb) against ABCB5 (ATP-binding cassette transporter, sub-family B (MDR/TAP), member 5) with the potential to be used in research on melanoma. MW: 147.74 KD. |
| L6200 |
Anti-Aging Compound Library |
A unique collection of 2316 anti-aging compounds used for aging related research. |
| A2722 |
Anti-Albumin |
Anti-Albumin is a human monoclonal antibody that is specific for human serum albumin (HSA) and has the potential to be used in research on type 1 diabetes. MW: 144.24 KD. |
| L5900 |
Anti-alzheimer Disease Compound Library |
A unique collection of 635 small molecules for exploring the mechanism of alzheimer's disease. |
| A2732 |
Anti-ANGPTL8 |
Anti-ANGPTL8 is a monoclonal antibody againts Angiopoietin-like protein (ANGPTL8) with potential to treat hypertriglyceridemia. MW: 145.16 KD. |
| A2726 |
Anti-ANO1 / TMEM16A |
Anti-ANO1 / TMEM16A is a humanized monoclonal antibody that binds to human TMEM16A and modulates its activity, with potential anti-tumor activity. MW: 146.8 KD. |
| A3026 |
Anti-ASIC1 |
Anti-ASIC1 is a mouse monoclonal antibody targeting acid-sensing ion channel-1 (ASIC1). It exhibits potential application in pain,neurodegenerative diseases, and psychiatric diseases. MW :144.04 KD. |
| A3001 |
Anti-AXL / UFO (ORY012) |
Anti-AXL / UFO (ORY012) is a polyclonal antibody that targets receptor tyrosine kinase AXL (UFO). It can be used in research of glioblastoma multiforme (GBM) and pancreatic cancers. MW :146.28 KD. |
| A3053 |
Anti-BST2 / CD317 |
Anti-BST2 / CD317 monoclonal antibody that targets Bone marrow stromal antigen 2. It can be used in cancer research. MW :145.52. KD. |
| A2742 |
Anti-c-RET |
Anti-c-RET is a monoclonal antibody against the receptor tyrosine kinase Ret (c-Ret) expressed in cells of neuroblastoma and substantia nigra, a responsive locus of Parkinson's disease. MW: 146.74 KD. |
| A2580 |
Anti-C1q |
Anti-C1q (ANX005) is a recombinant antibody against C1q. It inhibits its function as the initiating molecule of the classical complement cascade. It is used in research of autoimmune and neurodegenerative diseases. MW:145.5 KD. |
| F1700 |
Anti-C3 Rabbit mAb |
C3,C3 / C3b,Complement C3 |
| F0032 |
Anti-Calbindin-D-28K Mouse mAb |
Calbindin,Calbindin D28K,Calbindin D-28K,Calbindin-D-28K |
| L3000 |
Anti-cancer Compound Library |
A unique collection of 4256 anti-cancer compounds for multiple cancers: Breast Cancer, Leukemia, Lung Cancer, Lymphoma, etc. |
| L7100 |
Anti-cancer Compound Library-Ⅱ |
A unique collection of 897 compounds with anticancer activity which has been verified by broad institute,half of the compounds are non-oncology drugs. |
| L5700 |
Anti-cancer Metabolism Compound Library |
A unique collection of 339 small molecules for cancer metabolism research. |
| L7500 |
Anti-Cardiovascular Disease Compound Library |
A unique collection of 704 anti-cardiovascular disease related compounds used for high throughput screening(HTS) and high content screening(HCS). |
| A2793 |
Anti-CD151 |
Anti-CD151 is an anti-CD151 monoclonal antibody (mAb) with potential anti-metastatic and anti-tumor activity activity. MW: 146.76 KD. |
| A2817 |
Anti-CD34 |
Anti-CD34 is a humanized monoclonal antibody against CD34 surface antigen on human stem cells. MW: 145.9 KD. |
| A2831 |
Anti-CD59 |
Anti-CD59 is a humanized monoclonal antibody against CD59 with the potential to treat anti-tumour activity. MW: 145.08 KD. |
| A2837 |
Anti-CD83 |
Anti-CD83 is a humanized monoclonal antibody against CD83 with the potential to treat auto-immune diseases. MW: 144.8 KD. |
| A2838 |
Anti-CD9 |
Anti-CD9 is a humanized monoclonal antibody against CD9 with potential anti-tumor activity. MW: 145.98 KD. |
| A2839 |
Anti-CDH1 / E-cadherin / CD324 |
Anti-CDH1 / E-cadherin / CD324 is an IgG1 monoclonal antibody against E-cadherin, an epithelial adhesion molecule. MW: 146.6 KD. |
| A3154 |
Anti-CDH17 / Cadherin-17 (10C12) |
Anti-CDH17 / Cadherin-17 (10C12) is a humanized monoclonal antibody targeting Cadherin-17 (CDH17), a prominent cancer biomarker. It has growth inhibitory effect on liver and stomach tumour cells. It can be used as therapeutics for treating lung metastasis of hepatocellular carcinoma (HCC). MW :143.68 KD. |
| A3155 |
Anti-CDH17 / Cadherin-17 (PTA001_A4) |
Anti-CDH17 / Cadherin-17 (PTA001_A4) is a humanized monoclonal antibody targeting Cadherin-17 (CDH17), a prominent cancer biomarker. It has growth inhibitory effect on tumour cells. It can be used as therapeutics for treating various cancers, including colorectal cancer. MW :149.12 KD. |
| A2639 |
Anti-CEACAM6 / CD66c (NEO-201) |
Anti-CEACAM6 / CD66c (NEO-201) is a humanized IgG1 monoclonal antibody that targets of CEACAM family. It enhances natural killer cell cytotoxicity against tumor cells. MW :145.48 KD. |
| A2640 |
Anti-CHI3L1 |
Anti-CHI3L1 is a monoclonal antibody targeting Chitinase 3–like 1 (CHI3L1). It proves a promising therapy for pulmonary metastasis and progression. MW :147.04 KD. |
| A2844 |
Anti-Clathrin Heavy Chain / CHC |
Anti-Clathrin Heavy Chain / CHC is a human monoclonal antibody against clathrin heavy chain (CHC) with potential anti-angiogenesis and anti-tumor activity. MW: 145.62 KD. |
| A3250 |
Anti-CLDN6 |
Anti-CLDN6 is a fully humanized antibody targeting Claudin-6 (CLDN6). It is conjugated to MMAE through a cleavable linker, forming a drug conjugate and exhibits anti-tumor activity. |
| A2643 |
Anti-CLDN6 (IMAB027) |
Anti-CLDN6 (IMAB027) is a fully humanized antibody targeting CLDN6. It gets conjugated to monomethyl auristatin E( MMAE) resulting in the potential therapeutic CLDN6–23-ADC. It exhibits antitumor efficacy in ovarian epithelial carcinomas.MW :144.42 KD. |
| A2627 |
Anti-Complement C5aR1 (G2_anti-C5aR) |
Anti-Complement C5aR1 (G2_anti-C5aR) is a rat monoclonal antibody that detects Complement 5a receptor (C5aR). It exhibit potent proinflammatory stimulus with immunomodulatory activities. MW :146.08 KD. |
| A2714 |
Anti-Complement Factor P / Properdin |
Anti-Complement Factor P / Properdin is a monoclonal anti-Properdin antibody with the potential to treat chronic complement-mediated and complement-associated disorders. MW: 145.54 KD. |
| A2530 |
Anti-CSF3 / G-CSF |
Anti-CSF3 / G-CSF (CSL324) is an antibody targeting CSF3. It is useful for studying growth factor signaling. MW: 145.5 KD. |
| A2656 |
Anti-CSF3R / G-CSFR |
Anti-CSF3R / G-CSFR is an antibody that targets G-CSF. I t can be used in the research of inflammatory diseases. MW :150 KD. |
| A2733 |
Anti-CXC-ELR |
Anti-CXC-ELR is a monoclonal antibody that binds to an ELR+ CXC chemokine and inhibits its biological activity. MW: 146.56 KD. |
| A2721 |
Anti-CXCL4 / PF4 |
Anti-CXCL4 / PF4 is a monoclonal antibody against anti-CXC chemokine ligand 4 (CXCL4, also called PF4). MW: 144.86 KD. |
| A2524 |
Anti-CXCL8 / IL-8 |
Anti-CXCL8 / IL-8 (ABX-IL8) is a antibody targeting CXCL8. MW: 145.5 KD. |
| A2646 |
Anti-CXCL9 |
Anti-CXCL9 is an antibody targeting CXCL9 chemokine. It has the potemtial of inhibiting inflammation. MW :150 KD. |
| A2706 |
Anti-CXCR3 / GPR9 / CD183 |
Anti-CXCR3 / GPR9 / CD183 is a monoclonal antibody binds to Chemokine (C-X-C motif) receptor 3 (CXCR3, also known as G protein-coupled receptor 9 (GPR9)) . It has the potentially to be used in the treatment of diabetes mellitus type I (T1D). MW: 146.38 KD. |
| A3046 |
Anti-CYR61 / CCN1 |
Anti-CYR61 / CCN1 is a monoclonal antibody targeting cysteine-rich protein 61(CCN1/Cyr61) . It can be used in breast cancer treatment. MW :144.42 KD. |
| A2648 |
Anti-DC-SIGN / CD209 |
Anti-DC-SIGN / CD209 is a humanized monoclonal antibody that specifically targets DC-SIGN. It inhibits infection caused by human cytomegalovirus (CMV) in immunocompromised patients, namely in organ-transplanted recipients or AIDS patients. ME :146.62 KD. |
| L2900 |
Anti-diabetic Compound Library |
A unique collection of 155 small molecules for exploring the development of diabetes. |
| A2749 |
Anti-DSG3 |
Anti-DSG3 is an anti-desmoglein 3 (Dsg3) monoclonal antibody that depletes desmosomes of Dsg3 and has the potential to be used in research on Pemphigus vulgaris (PV). MW: 146.54 KD. |
| A2740 |
Anti-Dysadherin |
Anti-Dysadherin is a monoclonal antibody against dysadherin with anti-metastasis activity. MW: 147.56 KD. |
| A2794 |
Anti-EMMPRIN / CD147 |
Anti-EMMPRIN / CD147 is a monoclonal antibody against extracellular matrix metalloproteinase inducer (EMMPRIN; CD147) with potential anti-proliferative activity. MW: 145.42 KD. |
| A2513 |
Anti-ENTPD1 / CD39 |
Anti-ENTPD1 / CD39 (TTX-030) is a fully human monoclonal antibody directed targeting the cell surface receptor CD39. It specifically binds to the CD39 antigen and inhibits both the conversion of adenosine triphosphate (ATP) to adenosine monophosphate (AMP) and the subsequent generation of immunosuppressive extracellular adenosine in the tumor microenvironment (TME). MW: 145.5 KD. |
| A2511 |
Anti-EphA2 (MEDI-547) |
Anti-EphA2 (MEDI-547) is a fully human IgG1 monoclonal antibody that is used for targeting EphA2. It selectively binds to cells expressing the EphA2 receptor. MW: 145.12 KD. |
| A2915 |
Anti-ERG |
Anti-ERG is a monoclonal IgG1 antibody (mAb) directed against the proto-oncogene ETS-related gene (ERG). It has the potential to treat prostate cancer, Ewing's sarcoma, acute myeloid leukemia, endothelial cancer, and colon cancer. MW: 145.4. |
| A2961 |
Anti-F8 / Factor VIII |
Anti-F8 / Factor VIII is a monoclonal IgG anti-factor VIII antibody that hydrolyzes FVIII in acquired hemophilia. MW: 145.14 KD. |
| A2750 |
Anti-FcgR3a / CD16a (AFM13) |
Anti-FcgR3a / CD16a (AFM13) is a tetravalent bispecific antibody directed against human CD30 and the human low affinity IgG Fc region receptor (FCGR3A; CD16A), with potential immunomodulating and antineoplastic activities. MW: 124.56 kD. |
| A2909 |
Anti-FGFR1 / CD331 |
Anti-FGFR1 / CD331 is a monoclonal antibody againts human fibroblast growth factor receptor 1. MW: 150 KD. |
| A2493 |
Anti-FLT3 / CD135 |
Anti-FLT3 / CD135 (IMC-EB10) is a fully human IgG1 monoclonal antibody, targeting the FLT3 tyrosine kinase receptor (CD135) with potential antineoplastic activity. It binds to FLT3 and blocks FLT3 ligand binding to FLT3 and subsequent FLT3 phosphorylation, which may result in the inhibition of FLT3-mediated signal transduction pathways. MW: 145.5 KD. |
| A3091 |
Anti-GAD65 |
Anti-GAD65 is an autoantibody targeting glutamic acid decarboxylase (GAD65). It is used in treatment of Stiff person syndrome (SPS). MW :146.38 KD. |
| A3116 |
Anti-GLP1R |
Anti-GLP1R is a humanized antibody targeting GLP-1 receptor (GLP-1R). It can be used in therapy for type 2 diabetes mellitus. MW : 144.5 KD. |
| A2710 |
Anti-GOLM1 |
Anti-GOLM1 is a monoclonal antibody against Golgi protein-73 (GP73, Golgi Membrane Protein 1, GOLM1) with the potential to be used in research on hepatocellular carcinoma (HCC). MW: 145.62 KD. |
| D4061 |
Anti-GPC3 / Glypican-3 (Codrituzumab-MMAE) |
Anti-GPC3 / Glypican-3 (Codrituzumab-MMAE) is an antibody-drug conjugate (ADC) targeting GPC3 (glypican-3). It induces antibody-dependent cellular cytotoxicity (ADCC) and inhibits tumor growth and can be used in the research of hepatocellular carcinoma (HCC). MW :145.58 KD. |
| A2709 |
Anti-GPR44 / PTGDR2 / CD294 |
Anti-GPR44 / PTGDR2 / CD294 is a monoclonal antibody against a transmembrane G-protein-coupled receptor (GPR44, also known as CRTH2, PTGDR2,or CD294) with the potential to treat asthma. MW: 147.66 KD. |
| A2925 |
Anti-GPR64 / ADGRG2 |
Anti-GPR64 / ADGRG2 is a monoclonal antibody (mAb) against G protein-coupled receptor 64 isoform 4 (anti-GPR64) with potential anti-tumour activity. MW: 146.1. |
| A2473 |
Anti-GPRC5D |
Anti-GPRC5D is a specific antibody against G protein-coupled receptor C5 family member D (GPRC5D). |
| A2711 |
Anti-GREM1 / Gremlin |
Anti-GREM1 / Gremlin is a monoclonal antibody that binds to human gremlin-1 (GREM1) with potential anti-tumor activity. MW: 144.58 KD. |
| A5994 |
Anti-HA Plus Mouse Monoclonal Antibody |
Anti-HA Plus Monoclonal Antibody can be used for the detection, isolation and purification of HA-tagged proteins. |
| A2659 |
Anti-Haptoglobin |
Anti-Haptoglobin is an antibody targeting the human haptoglobin (HP). It can be used for immunoblotting after isoelectric focusing to determine Hp alpha subtypes. MW :150 KD. |
| A2717 |
Anti-HGFA |
Anti-HGFA is a monoclonal anti-HGFA antibody that detects endogenous levels of HGFA protein in biological samples. MW: 141.18 KD. |
| A2730 |
Anti-Histone H3 |
Anti-Histone H3 is a monoclonal anti-Histone H3 antibody antibody used for detection of Histone H3 (histone 3-H3). MW: 150 KD. |
| A2465 |
Anti-HLA-DR |
Anti-HLA-DR (IMMU-114) is a humanized anti-human leukocyte antigen-DR (HLA-DR) moAb, that depletes APCs and reduces alloreactive T cells. MW: 145.5 KD. |
| A2127 |
Anti-human CD28-InVivo |
Anti-human CD28-InVivo (Clone: 9.3) monoclonal antibody reacts with human CD28, a 45 kDa costimulatory receptor and a member of the Ig superfamily. It stimulate the proliferation of human T cells in vitro. |
| A2168 |
Anti-human CD3 (UCHT1)-InVivo |
Anti-human CD3 (UCHT1)-InVivo reacts with human CD3ε a 20 kDa transmembrane cell-surface protein that belongs to the immunoglobulin superfamily |
| A2111 |
Anti-human CD3-InVivo |
The OKT-3 monoclonal antibody reacts with human CD3ε which is a 20 kDa transmembrane cell-surface protein that belongs to the immunoglobulin superfamily.The OKT-3 antibody has immunosuppressive properties in vivo and has been shown to effectively treat renal, heart and liver allograft rejection. |
| A2172 |
Anti-human MHC Class I (HLA-A, HLA-B, HLA-C)-InVivo |
Anti-human MHC Class I (HLA-A, HLA-B, HLA-C)-InVivo reacts with the human major histocompatibility complex (MHC) class I, HLA-A, B, and C. All human nucleated cell express MHC class I antigens associated with β2-microglobulin. MHC class I plays a central role in cell-mediated immune responses and tumor surveillance. |
| A2156 |
Anti-human PD-L1 (B7-H1)-InVivo |
Anti-human PD-L1 (B7-H1)-InVivo reacts with human PD-L1 (programmed death ligand 1) also known as B7-H1 or CD274. PD-L1 is a 40 kDa type I transmembrane protein that belongs to the B7 family of the Ig superfamily. |
| A2113 |
Anti-human/mouse TGF-β-InVivo |
The 1D11.16.8 monoclonal antibody reacts with mouse, human, rat, monkey, hamster, canine and bovine TGF-β (transforming growth factor beta) isoforms 1, 2 and 3.The 1D11.16.8 monoclonal antibody is a neutralizing antibody. |
| A2873 |
Anti-ICAM3 / CD50 |
Anti-ICAM3 / CD50 is an IgG1 monoclonal antibody against intercellular adhesion molecules-3 (ICAM-3, also known as CD50)) with the potential to have anti-proliferative activities. MW: 145.22 KD. |
| A2663 |
Anti-IDO2 |
Anti-IDO2 is a monoclonal antibody targeting Indoleamine 2,3-dioxygenase 2 (IDO2). It exhibits potency that ameliorates arthritis and autoimmune disease. MW :151.06 KD. |
| A2666 |
Anti-IL-13Ra2 / CD213a2 |
Anti-IL-13Ra2 / CD213a2 is a humanized monoclonal antibody targeting IL-13Ra2. It exhibits potentcy against malignant gliomas (MG), head and neck tumors, ovarian cancer and kidney cancer. MW :150 KD. |
| A2439 |
Anti-IL-22Ra |
Anti-IL-22Ra is an affinity isolated polyclonal antibody, targeting IL-22R. It is used in the treatment of psoriasis, psoriatic arthritis, atopic dermatitis. MW :145.5 KD. |
| A2797 |
Anti-IL-25 |
Anti-IL-25 is a humanised monoclonal antibody against Interleukin-25 (IL-25) with the potential to treat airway hyperresponsiveness (AHR). MW: 146.02 KD. |
| A2631 |
Anti-IL-3Ra / CD123 (SGN-CD123A) |
Anti-IL-3Ra / CD123 (SGN-CD123A) is an antibody-drug conjugate targeting IL-3 alpha chain receptor (CD123). It is a potent antileukemic agent in treatment of acute myelogenous leukemia(AML). MW :146.14 KD. |
| A2982 |
Anti-IL-6Ra / CD126 (APX007) |
Anti-IL-6Ra / CD126 (APX007) is a monoclonal antibody targeting IL-6R/CD126. It can be used in the pathogenesis of multiple myeloma. MW :144.6 KD. |
| L3100 |
Anti-infection Compound Library |
A unique collection of 1565 anti-infection compounds with biological activity of antibacterial,antifungal,antiviral,etc. |
| A3006 |
Anti-INHBB / Activin B |
Anti-INHBB / Activin B is a monoclonal antibody targeting the betaB subunit of Activin B. It has potent uses in treatment of fatigue syndrome/myalgic encephalomyelitis (CFS/ME). MW:146.02 KD. |
| A2745 |
Anti-Integrin a11 / ITAG11 |
Anti-Integrin a11 / ITAG11 is a monoclonal antibody against Integrin alpha 11 (ITGA11), a transmembrane glycoprotein expressed in adult cardiac and uterine smooth muscle and developing myocytes. MW: 145.7 KD. |
| D4062 |
Anti-KAAG1 (ADCT-901-MMAE) |
Anti-KAAG1 (ADCT-901-MMAE) is an ADC composed of a humanized monoclonal antibody (3A4) targeting human KAAG1. It is used for the treatment of advanced solid tumors including platinum resistant ovarian cancer and triple negative breast cancer. MW :145.28 KD. |
| A2929 |
Anti-KID3 |
Anti-KID3 is a monoclonal antibody (MAb) directed against KID3, a carbohydrate epitope found in the colon and several forms of cancer. MW: 147.04 KD. |
| A2718 |
Anti-KLK5 / Kallikrein 5 |
Anti-KLK5 / Kallikrein 5 is a monoclonal antibody kallikrein-related peptidase 5 (KLK5) with the potential to be used in research on immune-based therapies. MW: 144.76 KD. |
| A2146 |
Anti-LCMV nucleoprotein-InVivo |
Anti-LCMV nucleoprotein-InVivo reacts with lymphocytic choriomeningitis virus (LCMV) nucleoprotein (NP), a 63 kDa structural protein. |
| A2672 |
Anti-MAGEA3 |
Anti-MAGEA3 is an antibody that targets MAGE-A. It can be used in the treatment of metastatic cancer treatment. MW :145.56 KD. |
| A2737 |
Anti-Matriptase |
Anti-Matriptase is a monoclonal matriptase-specific antibody. MW: 144.28 KD. |
| A3002 |
Anti-Mesothelin (BMS-986148) |
Anti-Mesothelin (BMS-986148) is a fully human IgG1 monoclonal antibody targeting mesothelin. It is used to synthesize antibody-drug conjugate (ADC). It has potential multimodal therapeutic strategies in patients with advanced solid tumors. MW :150 KD. |
| A3092 |
Anti-MICB |
Anti-MICB is an antibody that specifically target human major histocompatibility complex class I chain-related A and B (MICA/B). It can be used in treating a cancer. MW :143.66 KD. |
| A2143 |
Anti-mouse 4-1BB (CD137)-InVivo |
Anti-mouse 4-1BB (CD137)-InVivo reacts with mouse 4-1BB, a TNF receptor superfamily member also known as CD137. |
| A2164 |
Anti-mouse B220-InVivo |
Anti-mouse B220-InVivo reacts with mouse B220 also known as CD45R. B220 is a 220 kDa transmembrane protein tyrosine phosphatase expressed on B cells and some subsets of T and NK cells. |
| A2110 |
Anti-mouse CD16/CD32-InVivo |
The 2.4G2 monoclonal antibody (Clone: 2.4G2)reacts specifically with mouse CD16 (FcγRIII) and CD32 (FcγRII). It has also been reported to react non-specifically via its Fc domain to FcγRI. The 2.4G2 antibody is commonly used in flow cytometry staining experiments to prevent non-specific binding of IgG to the FcγIII and FcγII, and possibly FcγI, receptors prior to staining with antigen specific primary antibodies. |
| A2149 |
Anti-mouse CD19-InVivo |
Anti-mouse CD19-InVivo reacts with mouse CD19, a B cell-specific 95 kDa transmembrane glycoprotein of the immunoglobulin superfamily. |
| A2107 |
Anti-mouse CD25 (IL-2Rα)-InVivo |
The PC-61.5.3 monoclonal antibody reacts with mouse IL-2Rα also known as CD25, Ly-43, p55, or Tac.The PC-61.5.3 antibody has been shown to inhibit the binding of IL-2 to both the low and high affinity IL-2 receptor forms. Additionally, the PC-61.5.3 antibody is commonly used to deplete CD4+FoxP3+ T regulatory cells in vivo. |
| A2166 |
Anti-mouse CD28(37.51)-InVivo |
Anti-mouse CD28(37.51)-InVivo reacts with mouse CD28, a 45 kDa costimulatory receptor and a member of the Ig superfamily. CD28 is expressed by thymocytes, most peripheral T cells, and NK cells. |
| A2167 |
Anti-mouse CD3-InVivo |
Anti-mouse CD3-InVivo reacts with mouse CD3, a transmembrane cell-surface protein that belongs to the immunoglobulin superfamily.CD3 is expressed on T lymphocytes, NK-T cells, and to varying degrees on developing thymocytes. |
| A2104 |
Anti-mouse CD3ε-InVivo |
The 145-2C11 monoclonal antibody reacts with mouse CD3ε which is a 20 kDa transmembrane cell-surface protein that belongs to the immunoglobulin superfamily. The 145-2C11 antibody has been shown to induce T lymphocyte activation, proliferation, and apoptosis in vitro via binding and stimulating the TCR. When used in vivo the antibody is reported to produce T cell activation, anergy, or death. |
| A2101 |
Anti-mouse CD4-InVivo |
Anti-mouse CD4 antibody(Clone: GK1.5) reacts with mouse CD4, which is a 55 kDa cell surface type I membrane glycoprotein. CD4 is a co-receptor of the T cell receptor (TCR) and assists the latter in communicating with antigen-presenting cells. |
| A2136 |
Anti-mouse CD40-InVivo |
Anti-mouse CD40-InVivo reacts with mouse CD40 also known as Bp50. CD40 is a type I transmembrane glycoprotein that belongs to the tumor necrosis factor receptor (TNFR) superfamily. |
| A2112 |
Anti-mouse CD40L (CD154)-InVivo |
The MR-1 monoclonal antibody reacts with mouse CD154 also known as CD40 ligand. The MR-1 monoclonal antibody has been reported to inhibit in vitro activation of B lymphocytes by blocking the binding of CD154 with CD40 on T helper cells as well as inhibit the formation of germinal centers and disrupt antigen-specific T cell responses. Additionally, the MR-1 antibody blocks interactions of T cells and antigen-presenting cells in vitro and blocks the development of experimental autoimmune disease in vivo. |
| A2154 |
Anti-mouse CD86 (B7-2)-InVivo |
Anti-mouse CD86 (B7-2)-InVivo reacts with mouse CD86 also known as B7-2. CD86 is an 80 kDa Ig superfamily member. |
| A2102 |
Anti-mouse CD8α-InVivo |
Anti-mouse CD8α (Clone:2.43)reacts with mouse CD8α. CD8 is a transmembrane glycoprotein that acts as a co-receptor for the T cell receptor (TCR). It binds to class I MHC molecules displayed by antigen presenting cells (APC). |
| A2137 |
Anti-mouse CD8β (Lyt 3.2)-InVivo |
Anti-mouse CD8β (Lyt 3.2)-InVivo reacts with mouse CD8β also known as Lyt 3.2. The CD8 antigen is a transmembrane glycoprotein that acts as a co-receptor for the T cell receptor (TCR). |
| A2170 |
Anti-mouse CSF1-InVivo |
Anti-mouse CSF1-InVivo reacts with mouse colony stimulating factor 1 (CSF1) also known as macrophage colony-stimulating factor (M-CSF). CSF1 is a hematopoietic growth factor that is expressed by many different cell types including fibroblasts, stromal cells, osteoblasts, activated T cells, macrophages, and B cells. |
| A2159 |
Anti-mouse CSF1R (CD115)-InVivo |
Anti-mouse CSF1R (CD115)-InVivo reacts with mouse colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), and CD115. CSF1R is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. |
| A2103 |
Anti-mouse CTLA-4 (CD152)-InVivo |
Anti-mouse CTLA-4 (CD152) antibody (Clone:9H10) reacts with mouse CTLA-4 (cytotoxic T lymphocyte antigen-4) also known as CD152. Anti-mouse CTLA-4 (CD152) antibody has been shown to promote T cell co-stimulation by blocking CTLA-4 binding to the B7 co-receptors, allowing for CD28 binding. |
| A2147 |
Anti-mouse CXCR3 (CD183)-InVivo |
Anti-mouse CXCR3 (CD183)-InVivo reacts with mouse CXCR3 also known as CD183, a 38 kDa chemokine receptor for CXCL9 (MIG), CXCL10 (IP-10), and CXCL11 (ITAC). |
| A2148 |
Anti-mouse GM-CSF-InVivo |
Anti-mouse GM-CSF-InVivo reacts with mouse granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony stimulating factor 2 (CSF2). |
| A2161 |
Anti-mouse ICOSL (CD275)-InVivo |
Anti-mouse ICOSL (CD275)-InVivo reacts with mouse ICOSL (inducible T cell co-stimulator ligand) also known as CD275, B7RP-1, and B7-H2. ICOSL is a 40 kDa immune checkpoint protein belonging to the Ig receptor superfamily. |
| A2121 |
Anti-mouse IFNAR-1-InVivo |
Anti-mouse IFNAR-1-InVivo monoclonal antibody (Clone: MAR1-5A3) reacts with mouse IFNAR-1 (IFN alpha/beta receptor subunit 1). Anti-mouse IFNAR-1-InVivo has been shown to inhibit Type I IFN receptor signaling in vitro and in vivo. |
| A2152 |
Anti-mouse IFNγ (XMG1.2)-InVivo |
Anti-mouse IFNγ (XMG1.2)-InVivo reacts with mouse IFNγ (interferon gamma) a 20 kDa soluble pleiotropic cytokine and the sole member of the type II class of interferons. |
| A2105 |
Anti-mouse IFNγ-InVivo |
The R4-6A2 monoclonal antibody reacts with mouse IFNγ (interferon gamma) which is a 20 kDa soluble pleiotropic cytokine and the sole member of the type II class of interferons. The R4-6A2 antibody has been shown to neutralize both natural and recombinant IFNγ. |
| A2151 |
Anti-mouse IL-10R (CD210)-InVivo |
Anti-mouse IL-10R (CD210)-InVivo reacts with mouse IL-10R (IL-10 receptor) also known as CD210. The IL-10R is a class II cytokine receptor and is expressed by a variety of cell types including thymocytes, T lymphocytes, B lymphocytes, NK cells, monocytes, and macrophages. |
| A2163 |
Anti-mouse IL-12 p40-InVivo |
Anti-mouse IL-12 p40-InVivo reacts with mouse p40 also known as IL-12β. p40 is a 40 kDa subunit of IL-12 and IL-23. IL-12 is a heterodimeric cytokine composed of subunits IL-12α p35 and IL-12β p40. |
| A2120 |
Anti-mouse IL-17A-InVivo |
Anti-mouse IL-17A-InVivo monoclonal antibody (Clone:17F3) reacts with mouse IL-17A which is a 15-20 kDa cytokine expressed by Th17 cells, γδ T cells, iNKT cells, NK cells, LTi cells, neutrophils, and intestinal Paneth cells. Anti-mouse IL-17A-InVivo has been shown to neutralize IL-17A in vivo. |
| A2134 |
Anti-mouse IL-18-InVivo |
Anti-mouse IL-18-InVivo (Clone:YIGIF74-1G7) monoclonal antibody reacts with mouse IL-18. IL-18 an 18 kDa pro-inflammatory cytokine is expressed by activated macrophages, keratinocytes, Kupffer cells, intestinal epithelial cells, and osteoblasts. |
| A2153 |
Anti-mouse IL-2 (S4B6-1)-InVivo |
Anti-mouse IL-2 (S4B6-1)-InVivo reacts with mouse IL-2, a 17 kDa cytokine that is mainly produced by T cells in response to antigenic or mitogenic stimulation. |
| A2138 |
Anti-mouse IL-2-InVivo |
Anti-mouse IL-2-InVivo reacts with mouse IL-2, a cytokine that is mainly produced by T cells in response to antigenic or mitogenic stimulation |
| A2109 |
Anti-mouse IL-4-InVivo |
The 11B11 monoclonal antibody reacts with mouse IL-4 (interleukin-4) which is a multifunctional 14 kDa cytokine.The 11B11 monoclonal antibody has been shown to neutralize the bioactivity of natural or recombinant IL-4. |
| A2118 |
Anti-mouse IL-6-InVivo |
Anti-mouse IL-6-InVivo monoclonal antibody (Clone:MP5-20F3) can reacts with mouse IL-6 (interleukin-6) which is a 21-28 kDa cytokine that is expressed by many cell types, including T lymphocytes, B lymphocytes, monocytes, fibroblasts, and endothelial cells. Anti-mouse IL-6-InVivo has been shown to neutralize the bioactivity of natural or recombinant IL-6. |
| A2157 |
Anti-mouse IL-6R-InVivo |
Anti-mouse IL-6R-InVivo reacts with the mouse IL-6 receptor α chain also known as CD126. CD126 is an 80 kDa type I cytokine receptor and a member of the immunoglobulin superfamily. |
| A2133 |
Anti-mouse LAG-3-InVivo |
Anti-mouse LAG-3-InVivo (Clone: C9B7W) monoclonal antibody reacts with mouse LAG-3 also known as CD223. LAG-3 promotes immune responses by activating antigen-presenting cells. The C9B7W antibody has been reported to block the function of murine LAG-3 in vivo and in vitro. |
| A2130 |
Anti-mouse LFA-1α (CD11a)-InVivo |
Anti-mouse LFA-1α (CD11a)-InVivo(clone M17/4) is a monoclonal antibody reacts with mouse LFA-1α (lymphocyte function-associated antigen 1 alpha) also known as integrin alpha L chain and CD11a. It plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50), and also functions in lymphocyte costimulatory signaling. |
| A2158 |
Anti-mouse Ly6G-InVivo |
Anti-mouse Ly6G-InVivo reacts with mouse Ly6G. Ly6G is a 21-25 kDa member of the Ly-6 superfamily of GPI-anchored cell surface proteins with roles in cell signaling and cell adhesion. |
| A2135 |
Anti-mouse Ly6G/Ly6C (Gr-1)-InVivo |
Anti-mouse Ly6G/Ly6C (Gr-1)-InVivo reacts strongly with mouse Ly6G and weakly with mouse Ly6C previously referred to as GR-1. Ly6G is a 21-25 kDa member of the Ly-6 superfamily of GPI-anchored cell surface proteins with roles in cell signaling and cell adhesion. |
| A2169 |
Anti-mouse MHC Class II (I-A/I-E)-InVivo |
Anti-mouse MHC Class II (I-A/I-E)-InVivo reacts with mouse MHC Class II haplotypes I-Ab, I-Ad, I-Aq, I-Ed, and I-Ek. The antibody does not react with I-Af, I-Ak, or I-As haplotypes. The M5/114 antibody is reported to inhibit I-A-restricted T cell responses. |
| A2114 |
Anti-mouse NK1.1-InVivo |
The PK136 monoclonal antibody(Clone: PK136) reacts with mouse NK1.1 also known as CD161b/CD161c, KLRB1, NKR-P1A and Ly-55. |
| A2125 |
Anti-mouse OX40 (CD134)-InVivo |
Anti-mouse OX40 (CD134)-InVivo (Clone: OX-86) monoclonal antibody reacts with mouse OX-40 also known as CD134. OX-40 plays a major role in regulating both CD4 and CD8 T cell clonal expansion. Anti-mouse OX40 (CD134)-InVivo treatment strongly enhances the generation of antigen-specific effector T cells, prevents the induction of T cell tolerance, and delays tumor growth in vivo. |
| A2165 |
Anti-mouse PD-1 (CD279)(29F.1A12)-InVivo |
Anti-mouse PD-1 (CD279)(29F.1A12)-InVivo reacts with mouse PD-1 (programmed death-1) also known as CD279. PD-1 is a 50-55 kDa cell surface receptor encoded by the Pdcd1 gene that belongs to the CD28 family of the Ig superfamily. |
| A2122 |
Anti-mouse PD-1 (CD279)-InVivo |
Anti-mouse PD-1 (CD279)-InVivo(Clone:RMP1-14) reacts with mouse PD-1 (programmed death-1) also known as CD279. PD-1 is a 50-55 kDa cell surface receptor encoded by the Pdcd1 gene that belongs to the CD28 family of the Ig superfamily. |
| A2171 |
Anti-mouse PD-L1 (B7-H1) (10F.2H11)-InVivo |
Anti-mouse PD-L1 (B7-H1) (10F.2H11)-InVivo reacts with mouse PD-L1 (programmed death ligand 1) also known as B7-H1 or CD274. The 10F.2H11 antibody has been shown to sterically and functionally block PD-L1/CD80 (B7-1) interactions and does not block PD-L1/PD-1 interactions. |
| A2115 |
Anti-mouse PD-L1 (B7-H1)-InVivo |
Anti-mouse PD-L1 (B7-H1)-InVivo (Clone:10F.9G2) monoclonal antibody reacts with mouse PD-L1 (also known as B7-H1, CD274). The 10F.9G2 antibody has been shown to block the interaction between PD-L1 and PD-1 and between PD-L1 and B7-1 (CD80). |
| A2141 |
Anti-mouse Ter-119-InVivo |
Anti-mouse Ter-119-InVivo reacts with mouse Ter-119, a 52 kDa glycophorin A-associated protein that is expressed by erythroid cells from the early proerythroblast stage to mature erythrocytes. Anti-mouse Ter-119-InVivo is commonly used for identifying erythrocytes and cells in the erythroid lineage. |
| A2129 |
Anti-mouse Thy1.2 (CD90.2)-InVivo |
Anti-mouse Thy1.2 (CD90.2)-InVivo(clone 30H12) is a monoclonal antibody reacts with mouse Thy1.2 also known as CD90.2. It induces Ca2+ flux in thymocytes and is particularly useful for depleting T lymphocytes. |
| A2144 |
Anti-mouse TIGIT-InVivo |
Anti-mouse TIGIT-InVivo reacts with mouse TIGIT (T cell immunoreceptor with Ig and ITIM domains). TIGIT is a 26 kDa, type I transmembrane protein and a member of the poliovirus receptor (PVR) family. |
| A2131 |
Anti-mouse TIM-3 (CD366)-InVivo |
Anti-mouse TIM-3 (CD366)-InVivo monoclonal antibody reacts with mouse TIM-3 (T cell immunoglobulin and mucin domain-3) also known as CD366. TIM-3 is specifically expressed at high levels on the surface of Th1 lymphocytes. This B8.2C12 antibody binds to the BALB/c allele of TIM-3 while reactivity to the C57Bl/6 allele. Inhibition of TIM-3 signaling in mice exacerbates experimental autoimmune encephalomyelitis and promotes IFNγ production and Th1 cell proliferation. |
| A2124 |
Anti-mouse TNFα-InVivo |
Anti-mouse TNFα-InVivo reacts with mouse TNFα (tumor necrosis factor-alpha), a multifunctional proinflammatory cytokine. TNFα dysregulation is been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. TNFα knockout animals display defects in response to bacterial infection, characterized by defects in forming organized follicular dendritic cell networks and germinal centers with a lack of primary B cell follicles. |
| A2126 |
Anti-mouse VEGFR-2-InVivo |
Anti-mouse VEGFR-2-InVivo (Clone: DC101) monoclonal antibody reacts with mouse VEGFR-2 (vascular endothelial growth factor receptor 2) also known as CD309, KDR, and Flk-1 and inhibit VEGFR-2 signaling in vivo. VEGFR-2 plays a key role in vascular development and permeability. |
| A2162 |
Anti-mouse/human VLA-4 (CD49d)-InVivo |
Anti-mouse/human VLA-4 (CD49d)-InVivo reacts with human and mouse VLA-4 α chain also known as CD49d and integrin alpha 4. VLA-4 is a 150 kDa glycoprotein belonging to the integrin family that is expressed by many cell types including T and B lymphocytes, monocytes, eosinophils, basophils, mast cells, thymocytes, NK cells, and dendritic cells. |
| A2132 |
Anti-mouse/human/rat CCL2 (MCP-1)-InVivo |
Anti-mouse/human/rat CCL2 (MCP-1)-InVivo (Clone: 2H5) antibody reacts with mouse, human, and rat CCL2, also known as monocyte chemoattractant protein 1 (MCP-1). MCP-1 is a 13 kDa chemokine produced mainly by monocytes/macrophages and is a potent monocyte-attracting chemokine. The 2H5 antibody has been shown to neutralize the biological effects of CCL2 in vivo. |
| A2140 |
Anti-mouse/human/rat CD47 (IAP)-InVivo |
Anti-mouse/human/rat CD47 (IAP)-InVivo reacts with mouse CD47 otherwise known as integrin-associated protein (IAP). CD47 is an approximately 50 kDa glycosylated five transmembrane protein that is ubiquitously expressed by both hematopoietic cells such as T and B lymphocytes, monocytes, platelets and erythrocytes and non-hematopoietic cells. |
| A2142 |
Anti-mouse/rat IL-1β-InVivo |
Anti-mouse/rat IL-1β-InVivo reacts with precursor and mature secreted forms of mouse and rat IL-1β a 17 kDa pro-inflammatory cytokine produced primarily by monocytes. |
| A3019 |
Anti-MRC2 / CD280 |
Anti-MRC2 / CD280 is a monoclonal antibody targeting ENDO180. It can be used as therapeutic strategy of sarcoma subtypes, primary tumor and in metastatic disease. MW :142.92 KD. |
| A2773 |
Anti-MSPR / RON / CD136 |
Anti-MSPR / RON / CD136 is a monoclonal antibody that blocks RON binding to its ligand, macrophage-stimulating protein (MSP), and can be used in cancer research. MW: 139.86 KD. |
| A5967 |
Anti-MTCO1 Mouse Recombinant mAb |
Anti-MTCO1 Mouse Recombinant mAb detects the level of MTCO1. |
| A2874 |
Anti-MUC17 |
Anti-MUC17 is an IgG1 monoclonal antibody against MUC17, a membrane-bound protein highly expressed on the surface of intestinal cells. MW: 146.66 KD. |
| A2752 |
Anti-MUSK |
Anti-MUSK is a monoclonal IgG antibody against muscle-specific kinase (MuSK) with the potential to treat Myasthenia gravis. MW: 145.24 KD. |
| A5968 |
Anti-Myc-Tag Mouse Recombinant mAb |
Anti-Myc-Tag detects the level of Myc-tagged target protein. |
| A2713 |
Anti-Nogo Receptor / NgR |
Anti-Nogo Receptor / NgR is a monoclonal anti-NgR antibody with the potential to promote axonal regeneration. MW: 146.18 KD. |
| A2719 |
Anti-Orai1 |
Anti-Orai1 is a human monoclonal anti-Orai1 antibody (mAb) with the potential to treat autoimmune diseases. MW: 143.86 KD. |
| A2633 |
Anti-OX2R / CD200R1 |
Anti-OX2R / CD200R1 is a monoclonal antibody targeting CD200. It exhibited potential in regulating tissue inflammation during skin wound healing. MW :146.58 KD. |
| L8200 |
Anti-parasitic Compound Library |
A unique collection of 237 anti-parasitic compounds used for high throughput screening(HTS) and high content screening(HCS). |
| A3017 |
Anti-PCLA |
Anti-PCLA is a fully human IgG4 monoclonal antibody targeting prostate cancer lipid-like antigen (PCLA) It can be used in treatment of prostate cancer. MW :145.52 KD. |
| A3024 |
Anti-PCSK9 (RG7652) |
Anti-PCSK9 (RG7652) is a fully human immunoglobulin G1 (IgG1) monoclonal antibody targeting proprotein convertase subtilisin/kexin type 9 (PCSK9). It exhibits potential efficacy in coronary heart disease (CHD). MW :144.84 KD. |
| A2684 |
Anti-PDGFC / VEGFE |
Anti-PDGFC / VEGFE is a monoclonal antibody targeting PDGF-CC. It can be used in the research of cancer, fibrosis and neuropathologies. MW :145.9 KD. |
| F1626 |
Anti-PGK1 Rabbit mAb |
|
| A2615 |
Anti-PMEL |
Anti-PMEL is a monoclonal antibody targeting human PMEL protein. It is used as a target for antibody drug conjugate (ADC) therapy in melanoma. MW :145.38 KD. |
| A2727 |
Anti-Polyubiquitin |
Anti-Polyubiquitin is a monoclonal anti-Polyubiquitin antibody used for isolating polyubiquitin chain-tagged proteins. MW: 144.98 KD. |
| A3047 |
Anti-PRLR / Prolactin Receptor |
Anti-PRLR / Prolactin Receptor is a potent monoclonal antibody, targeting prolactin (PRL) receptor. It is considered a good candidate for further development in endometriosis or other PRL-mediated disease conditions. MW :143.8 KD |
| A3049 |
Anti-RAMP3 |
Anti-RAMP3 is a polyclonal antibody targeting RAMP2. It is useful in the treatment of cancer. MW :147.04 KD. |
| A2160 |
Anti-rat Kappa Immunoglobulin Light Chain-InVivo |
Anti-rat Kappa Immunoglobulin Light Chain-InVivo reacts with the kappa chain of the rat immunoglobulin light chain. The κ chain is one of two types of polypeptide subunits which make up the immunoglobulin light chain. |
| A2367 |
Anti-ROBO1 |
Anti-ROBO1 is a bispecific antigen-binding construct targeting ROBO1, with a single-chain variable region antibody fragment ScFV binding to the surface antigen of immune cells and a Slit2D2 protein fragment binding to the surface antigen Robo1 of tumour cells.MW: 145.5 kD. |
| A2689 |
Anti-RSPO1 |
Anti-RSPO1 is a monoclonal antibodies against R-spondin1 gene (RSPO1) with potential anti-tumor activity . MW: 150 KD. |
| A2362 |
Anti-SCFR / c-Kit / CD117 |
Anti-SCFR / c-Kit / CD117 is a humanized monoclonal antibody against the stem cell factor receptor c-Kit (SCFR) with potential antineoplastic activity. MW : 150 kD. |
| A2756 |
Anti-SCN11a / Nav1.9 |
Anti-SCN11a / Nav1.9 is a monoclonal anti-Nav1.9 (SCN11A) antibody used in antigen-specific immunodetection in biological samples. MW: 143.94 KD. |
| A2728 |
Anti-SCN9a / Nav1.7 |
Anti-SCN9a / Nav1.7 is a fully human antibody that binds to human Nav1.7 (hNav1.7, SCN9a) with the potential to treat acute or chronic pain conditions or inflammatory conditions. MW: 145.72 KD. |
| A2720 |
Anti-SERPINE1 |
Anti-SERPINE1 is a monoclonal antibody that specifically binds to Plasminogen Activator Inhibitor Type-1 (PAI-1, SERPINE1) with the potential to be used in cardiovascular diseases. MW: 145.72 KD. |
| A3062 |
Anti-SLAMF7 / CS1 |
Anti-SLAMF7 / CS1 (PDL241) is a novel humanized monoclonal antibody, targeting CD319. It is a promising therapeutic target for rheumatoid arthritis. MW :144.92 KD. |
| A2857 |
Anti-Sphingosine-1-phosphate |
Anti-Sphingosine-1-phosphate is a human IgG1 monoclonal anti-Sphingosine-1-phosphate antibody that targets lysosphingolipids, thereby lowering the concentration of S1P in the extracellular fluid. MW: 145.74 KD. |
| A2723 |
Anti-STOP1 |
Anti-STOP1 is a human monoclonal antibody against stable tubule-only polypeptides (STOP), a protein responsible for microtubule cold stabilization. MW: 145.78 KD. |
| A2715 |
Anti-TAT226 |
Anti-TAT226 is a monoclonal antibody that binds to TAT226 with potential anti-tumor activity. MW: 144.66 KD. |
| A2695 |
Anti-TGFb1 (M7824) |
Anti-TGFb1 (M7824) is a bifunctional monoclonal antibody targeting programmed death ligand 1 (PD-L1) and transforming growth factor beta 1 (TGFb1). It exhibits anti-tumor efficacy against breast and colon carcinomas. |
| A2725 |
Anti-TIE2 / CD202b |
Anti-TIE2 / CD202b is a fully human monoclonal antibody that binds to human Tie2 and blocks the interaction between Tie2 or Tie2 ligands (angiopoietin). It has the potential to treat angiogenesis disorders. MW: 146.6 KD. |
| A2757 |
Anti-TLR7 |
Anti-TLR7 is a monoclonal antibody against Toll-like receptor 7 (TLR7) with the potential to treat autoimmune disease. MW: 145.04 KD. |
| A2741 |
Anti-TMEFF1 / Tomoregulin-1 |
Anti-TMEFF1 / Tomoregulin-1 is a monoclonal antibody against TMEFF1 (a transmembrane protein with EGF-like and two Follistatin-like domains, Tomoregulin 1), a type I transmembrane glycoprotein. MW: 146.08 KD. |
| A2724 |
Anti-TMEFF2 |
Anti-TMEFF2 is a human monoclonal anti-TMEFF2 antibody with potential anti-tumor activity. MW: 144.08 KD. |
| A2716 |
Anti-TMPRSS2 |
Anti-TMPRSS2 is a monoclonal antibody with possible antiviral activity that detects transmembrane serine protease 2 (TMPRSS2). MW: 146.06 KD. |
| A2650 |
Anti-TNFRSF21 / DR6 / CD358 |
Anti-TNFRSF21 / DR6 / CD358 is a humanized monoclonal antibody that specifically targets TNFRSF21. It can be used in treatment of cancer. MW :150 KD. |
| A2311 |
Anti-TrkA / NTRK1 |
Anti-TrkA / NTRK1 is a non-conjugated, rabbit-derived monoclonal antibody targeting TrkA. MW : 145.5 KD. |
| A3103 |
Anti-TrkB / NTRK2 |
Anti-TrkB / NTRK2 is an antibody targeting TrkB. It is used to improve nerve function, including treatment of peripheral neuropathies. MW :146.68 KD. |
| A2308 |
Anti-TSHR |
Anti-TSHR are unconjugated polyclonal antibodies derived from rabbi. Anti-TSHR are pathophysiologic, and also increases their significance in the diagnosis of autoimmune thyroid diseases and Graves' disease. |
| A2910 |
Anti-TSPAN8 |
Anti-TSPAN8 is a monoclonal IgG1 antibody (mAb) directed against Co-029, a membrane protein of the family of tetraspanins (TSPAN8 or TM4SF3). MW: 145.94 KD. |
| A3107 |
Anti-VCAM1 / CD106 |
Anti-VCAM1 / CD106 is a conjugated liposome targeting vascular cell adhesion molecule (VCAM)-1. It serves as a drug delivery system with dual functions: targeted delivery and solubilizing capacity. MW :143.4 KD. |
| A2302 |
Anti-VEGFC |
Anti-VEGFC is a fully human monoclonal antibody targeting the human vascular endothelial growth factor C (VEGFC or Flt4 ligand) with potential antiangiogenic activity and lymphangiogenesis. It also prevent metastasis. MW :145.5 KD. |
| S4936 |
Antiarol |
Antiarol (3,4,5-trimethoxyphenol) is a member of aromatic phenols and exhibits moderate DPPH free radical scavenging activity. |
| L5300 |
Antibiotics compound Library |
A unique collection of 483 antibiotics used for anti- research in order to identify drug target and open up new mechanism and ways to treat human disease. |
| P1144 |
Antide |
Antide(Iturelix), a gonadotropin-releasing hormone (GNRH) antagonist, inhibits apoptosis of preovulatory follicle cells in the rat ovary. |
| E2812 |
Antimalarial agent 1 |
Antimalarial agent 1 is a potent antimalarial drug. |
| S0323 |
Antineoplaston A10 |
Antineoplaston A10 is a naturally occurring substance in the human body that that can be potentially used for the treatment of glioma, lymphoma, astrocytoma and breast cancer. The main ingredient active of antineoplaston A10 (Phenylacetylglutamine, PG) inhibits RAS and promotes apoptosis. |
| L6500 |
Antioxidant Compound Library |
A unique collection of 817 compounds used for exploring the relationship between anti-oxidation and some diseases such as aging,cancer,alzheimer's disease,parkinson's disease,diabetes,etc. |
| S3173 |
Antipyrine |
Antipyrine (Phenazone,Phenazon) is an analgesic and antipyretic agent; selective COX-3 inhibitor. |
| L7000 |
Antiviral Compound Library |
A unique collection of 754 antiviral compounds used for exploring novel antiviral drug. |
| E3523 |
Antrodia cinnamomea Extract |
Antrodia Cinnamomea Extract is extracted from Antrodia Cinnamomea, which is a novel anticancer agent in tamoxifen-resistant breast cancer management. |
| S9146 |
Anwuligan |
Anwuligan (Macelignan), a natural compound isolated from Myristica fragrans Houtt, has antimicrobial and anticariogenic activity against Streptococcus mutans and other streptococcus species. It also shows antioxidant, free radical scavenging, and neuroprotective activities. |
| S4989 |
AOA (Aminooxyacetic acid) hemihydrochloride |
AOA (Aminooxyacetic acid) hemihydrochloride is an inhibitor of aminobutyrate aminotransferase involved in amino acid and polyamine metabolism. AOA hemihydrochloride is also a CBS (cystathionine β-synthase) inhibitor. |
| E1596 |
AOH1996 |
AOH1996 is an orally active small-molecule PCNA inhibitor with potential anti-tumor activity. It enhances the interaction between PCNA and RPB1, the largest subunit of RNA polymerase II. |
| F1469 |
AP-2α Rabbit mAb |
AP-2α,Transcription factor AP-2-alpha |
| S7443 |
AP-III-a4 (ENOblock) |
AP-III-a4 (ENOblock) is the first nonsubstrate analogue inhibitor of enolase with IC50 of 0.576 μM.
|
| E7674 |
AP1867 |
AP1867 is a synthetic FKBP12F36V-directed ligand. |
| S8487 |
AP20187 |
AP20187 (B/B Homodimerizer) is a chemical inducer of dimerization that activates FKBP-Casp8. |
| F3323 |
AP2S1 Rabbit mAb |
|
| S7295 |
Apabetalone (RVX-208) |
Apabetalone (RVX-208, RVX-000222) is a potent BET bromodomain inhibitor with IC50 of 0.510 μM for BD2 in a cell-free assay, about 170-fold selectivity over BD1. Phase 2. |
| F0671 |
Apaf-1 Rabbit mAb |
APAF1,Apaf-1 |
| S2840 |
Apalutamide (ARN-509) |
Apalutamide (ARN-509) is a selective and competitive androgen receptor inhibitor with IC50 of 16 nM in a cell-free assay, useful for prostate cancer treatment. Phase 3. |
| P1234 |
Apamin |
Apamin, an 18 amino acid peptide neurotoxin present in apitoxin (bee venom), has been shown to have anti-inflammatory and anti-fibrotic properties. It is known to be a highly selective blocker of Ca2+-activated K+ (SK) channels and then lessen the expression of α-SMA in the TGF-β1-induced HSC-T6 cells. |
| A2372 |
Apamistamab (Anti-PTPRC / CD45) |
Apamistamab (Anti-PTPRC / CD45) is an IgG1 anti-CD45 monoclonal antibody (MoAb). Note: This antibody is not labeled with the radioisotope iodine (-131). MW: 145.5 kD. |
| E1239 |
Apararenone |
Apararenone (MT-3995) is a selective, long-acting nonsteroidal mineralocorticoid receptors (MR) antagonist. |
| S5248 |
Apatinib |
Apatinib (Rivoceranib, YN968D1) is a potent inhibitor of the VEGF signaling pathway with IC50 values of 1 nM, 13 nM, 429 nM and 530 nM for VEGFR-2, Ret (c-Ret), c-Kit and c-Src, respectively. Apatinib induces both autophagy and apoptosis. |
| S2221 |
Apatinib (YN968D1) mesylate |
Apatinib mesylate (YN968D1, Rivoceranib) is a potent inhibitor of the VEGF signaling pathway with IC50 values of 1 nM, 13 nM, 429 nM and 530 nM for VEGFR-2, Ret (c-Ret), c-Kit and c-Src, respectively. Apatinib mesylate induces both autophagy and apoptosis. |
| H2988 |
APC Anti-BCRP1 (5D3) mAb |
Breast cancer resistance protein (BCRP1), also known as placenta-specific ATP-binding cassette (ABC) protein (ABCP) or ABC G-subfamily member 2 (ABCG2), or mitoxantrone resistance protein (MXR), is a member of the ATP-binding cassette superfamily of drug transporters thought to be involved in multi-drug resistance in human neoplastic disease. ABCG2 is expressed in drug-resistant breast, colon and gastric cancer and fibrosarcoma cancer cell lines and in blast cells from patients with acute myeloid leukemia (AML). Normal tissues that express the ABCG2 protein include placental syncytiothrophoblasts, mammary ducts and lobules, epithelium in the large intestine and colon, venous and capillary epithelium and bile canalicular membrane of the live |
| G0408 |
APC Anti-BrdU (BU20A) mAb |
Bromodeoxyuridine (5-bromo-2-deoxyuridine, BrdU) is a synthetic nucleoside that is an analogue of thymidine. BrdU is commonly used in the detection of proliferating cells in living tissues, and can be incorporated into the newly synthesized DNA of replicating cells (during the S phase of the cell cycle), substituting for thymidine during DNA replication. Antibodies specific for BrdU can then be used to detect the incorporated chemical, thus indicating cells that were actively replicating their DNA. Binding of the antibody requires denaturation of the DNA, usually by exposing the cells to acid or heat. |
| G0798 |
APC Anti-CD103/Integrin αE (2E7) mAb |
CD103, also known as ITGAE or Integrin alpha E, is a molecule that non-covalently associates with integrin beta 7 to form a heterodimeric integral membrane protein. This protein is part of the integrin family, characterized by an alpha chain and a beta chain. Specifically, CD103 includes a 150 kDa alpha chain and a 120 kDa beta chain, with the alpha integrin undergoing post-translational cleavage in the extracellular domain to yield disulfide-linked heavy and light chains. CD103 is primarily expressed on mucosa-associated T lymphocytes, intraepithelial lymphocytes (IELs), and activated cells, as well as a subset of TGF beta-1 cells. It is preferentially found in human intestinal IELs, where it plays a role in adhesion and may serve as an ac |
| G3453 |
APC Anti-CD105/Endoglin (MJ7/18) mAb |
CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up-regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation-associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2. |
| G0258 |
APC Anti-CD105/Endoglin (SN6) mAb |
CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2. |
| G4053 |
APC Anti-CD117/c-Kit (2B8) mAb |
KIT (c-KIT), also known as CD117, is a proto-oncogene and a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). KIT was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT together with its ligand regulates growth and activation of a variety of hemopoietic and non-hemopoietic cells. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Recently, deregulation of the KIT receptor TK by the prevalent activation loop mutation D816V has served as a focal point in therapeutic strategies aimed at curbing neoplastic mast cell growth. c-Kit is expressed in hematopoietic stem cells, germ cell |
| G2073 |
APC Anti-CD11b+CD11c (OX42) mAb |
CD11b (Integrin αM) and CD11c (Integrin αX) are α-chain integrins that belong to the β2 integrin family. They are primarily expressed on myeloid cells, including monocytes, macrophages, dendritic cells, and neutrophils. These integrins play key roles in cell adhesion, migration, phagocytosis, and immune regulation through interactions with ligands such as iC3b, ICAM-1, and fibrinogen. CD11b is highly expressed on monocytes and neutrophils, whereas CD11c is widely used as a marker for dendritic cells. |
| G0093 |
APC Anti-CD11c (N418) mAb |
CD11, along with CD18, form a heterodimer adhesion molecule. In particular, CD11 is composed of CD11a, CD11b and CD11c. CD11a is a leukocyte marker that is expressed in B and T lymphocytes, macrophages, monocytes, neutrophils, basophils and eosinophils. CD11b is primarily expressed by monocytes, macrophages, natural killer cells, some B and T-cells, and granulocytes. CD11c is expressed in monocytes, macrophages, natural killer cells, some granulocytes and less so in a subset of lymphocytes. |
| G2973 |
APC Anti-CD122/IL-2Rβ (TM-β1) mAb |
CD122 (Interleukin 2 receptor) is involved in T cell-mediated immune responses, primarily expressed in the hematopoietic system and is present in 3 forms. The low affinity form of CD122 is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from CD122. The protein encoded by the CD122 gene represents the beta subunit and is a type I membrane protein. Diseases associate with CD122 protein dysfunction include oligoarti |
| G0453 |
APC Anti-CD127 (A7R34) mAb |
CD127, also known as the Interleukin-7 receptor alpha chain (IL-7Ralpha), is a type I glycoprotein with a molecular weight of 75-80 kDa. It forms a multi-functional receptor complex with CD132, the common gamma chain, to create the IL-7 receptor (IL-7R), which is crucial for lymphopoiesis. The active IL-7 receptor is an alpha/gamma chain heterodimer, where the gamma chain also associates with the interleukin-2 receptor and primarily activates signal transduction, while the alpha chain determines specific signaling events through its association with cytoplasmic signaling molecules. CD127 is expressed by immature B cells through the early pre-B stage, thymocytes during various stages of development, and most mature T cells, with transient do |
| G0768 |
APC Anti-CD135/Flt3 (A2F10) mAb |
FLT3 is a tyrosine protein kinase that is a member of the growth factor receptor tyrosine kinase family. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. |
| H0333 |
APC Anti-CD161 (HP-3G10) mAb |
CD161, also known as NKR-P1A, is a type II transmembrane lectin-like receptor and member of the killer cell lectin-like receptor (KLR) family. CD161 exists as a homodimer and is prominently expressed on natural killer (NK) and NKT cells, where it is proposed to regulate the function of both cell types. CD161 is also found on T cell subsets, including T regulatory cells (Tregs), memory/effector CD4+ T cells, and CD8+ T cells. Th17 cells have been demonstrated to co-express CD161, as surface IL-17A+ cells are contained within the CD161+ fraction of CD4 T cells, so that CD161 (in combination with CCR6) is often used as a marker for enrichment of Th17 cells. |
| G0603 |
APC Anti-CD184/CXCR4 (2B11) mAb |
CXCR4 (Fusin, LESTR, HUMSTR) is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains, and functions as a co-receptor for X4 HIV-1 entry into CD4+ cells. CXCR4 has been proved to be the co-receptor for HIV-2's binding to CD4 through envelope glycoprotein gp 120 and promotes Env-mediated fusion of the virus. In other cases, CXCR4 can even function as the only receptor for HIV-2's binding to the CD4 host cells. CXCR4 is the receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. CXCR4 acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced c |
| G1713 |
APC Anti-CD1d (1B1) mAb |
CD1d is a heavy chain associated with Beta 2 microglobulin on cortical thymocytes. Beta 2 microglobulin independent expression of CD1d has also been demonstrated on human intestinal epithelial cells. CD1d is the sole group 2 member of the CD1 family of major histocompatibility (MHC) like glycoproteins. The CD1d gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 |
| G4128 |
APC Anti-CD23 (B3B4) mAb |
CD23 is a 45 kDa glycoprotein that serves as a low-affinity receptor for IgE, playing a crucial role in regulating IgE responses and B cell activation. It is expressed on mature B cells, mantle zone B cells, follicular dendritic cells, and at lower levels on T cells, NK cells, Langerhans cells, and platelets. CD23 expression is upregulated upon B cell activation, and its soluble forms are biologically active, acting as potent mitogenic factors. CD23 is strongly expressed on Epstein-Barr virus (EBV)-transformed B lymphoblasts and is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells. It is also detected in neoplastic cells from cases of B cell chronic lymphocytic leukemia and some centroblastic/centrocytic lym |
| G0273 |
APC Anti-CD24 (M1/69) mAb |
CD24 is a 35-50 kDa glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed on a variety of cell types, including erythrocytes, thymocytes, peripheral lymphocytes, and cells of the myeloid lineage. It is variably glycosylated, resulting in heterogeneity in molecular mass across different cell lineages, which can affect antibody staining levels on lymphocyte populations. In the context of B-cell development, CD24 is expressed from the pro-B-cell stage in the bone marrow through to mature, surface Ig-positive B cells, with very low or negative expression on plasma cells. It is also present on the majority of B-lineage acute lymphoblastic leukemias, B-cell chronic lymphocytic leukemias (CCLs), and B-cell non-Hodgkin's lymphomas. CD2 |
| H2958 |
APC Anti-CD262/DR5 (DJR2-4 (7-8)) mAb |
DR5 is expressed broadly by normal tissues as well as several tumor cells. DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a recently identified death domain containing receptor for TRAIL, which mediates TRAIL induced apoptosis. DR5 is a member of the TNF-receptor superfamily, and contains an intracellular death domain. DR5 can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by DR5. Two transcript variants encoding different isoforms of DR5 and one non-coding transcript have been found. Overexpression of DR5 induces apoptosis and ac |
| H0168 |
APC Anti-CD27 (O323) mAb |
CD27 (TNFRSF7) is a cell surface homodimer of ≥55 kDa subunits that provides co-stimulatory signaling in support of T cell (TCR) and B cell (BCR) receptors. Compared to CD28, whose TCR co-stimulatory signal can trigger cell proliferation, CD27 signaling promotes cell survival and differentiation to effector/memory stages. CD27 may be shed following interaction with its ligand CD70, which is typically expressed on activated dendritic cells, T cells, and B cells. In B cells, CD27 is a phenotypic marker for memory B cells and has also been included among markers for identifying B regulatory cells (Bregs), which regulate CD4+ T cell proliferation and Foxp3/CTLA-4 expression in Treg cells. |
| H0693 |
APC Anti-CD284/TLR4 (HTA125) mAb |
TLR4 is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This receptor is most abundantly expressed in placenta, and in the myelomonocytic subpopulation of leukocytes. Mammalian cells respond to LPS by activating TLR4. TLR4 belongs to the multi-protein complex of the lipopolysaccharide (LPS) receptor, containing CD14, LY96, and TLR4, and is involved in signal transduction events induced by LPS found in most gram-negative bacteria. TLR4 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents and |
| G0573 |
APC Anti-CD29/ITG-β1(C13M2) mAb |
CD29, also known as ITGB1 or Integrin Subunit Beta 1, is a 110 kDa cell surface glycoprotein widely expressed by various cells, including all leukocytes. It forms non-covalently linked heterodimers with at least six different alpha integrins (CD49a-f), creating VLA-1 through VLA-6 complexes, as well as with CD51. These alpha-beta integrin heterodimers mediate a range of cellular responses, including adhesion, trafficking, proliferation, and differentiation. CD29-containing integrins bind to extracellular matrix proteins such as collagen, laminin, fibronectin, and vitronectin. Some integrins also interact with cellular receptors like VCAM-1 and MadCAM-1. CD29 plays a crucial role in immune cell trafficking from blood to tissue, particularly |
| G0198 |
APC Anti-CD31/PECAM-1 (390) mAb |
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulatio |
| G4098 |
APC Anti-CD326/EpCAM (G8.8) mAb |
Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA), also known as CD326, is a transmembrane glycoprotein expressed in the epithelium with a molecular weight of approximately 40 kDa, which functions as an epithelial cell adhesion molecule. Ep-CAM functions as a homotypic calcium-independent cell adhesion molecule, and has a direct impact on cell cycle, proliferation and metabolism of epithelial cells and fibroblasts due to its ability to rapidly induce the proto-oncogene c-myc and the cell cycle regulating genes cyclin A and E. Ep-CAM mediates Ca2+-independent homotypic interactions. Formation of Ep-CAM-mediated adhesions have a negative regulatory effect on adhesions mediated by classic cadherins, which may have strong |
| G0078 |
APC Anti-CD44 (IM7) mAb |
CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential. CD44 is expressed by hematopoietic, non-hematopoietic cells, epithelial tissu |
| G0018 |
APC Anti-CD45 (30-F11) mAb |
CD45, also known as Leukocyte Common Antigen (LCA). CD45 is expressed by all hematopoietic cells excluding mature erythrocytes and platelets. The cytoplasmic portion of CD45 has tyrosine phosphatase enzymatic activity and plays an important role in activation of lymphocytes.
|
| G0348 |
APC Anti-CD45.1 (A20) mAb |
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides t |
| G0108 |
APC Anti-CD45R/B220 (RA3-6B2) mAb |
CD45R (PTPRC) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. CD45 contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. CD45 is specifically expressed in hematopoietic cells and has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists in multiple isoforms as a result of alternative splicing, and these isoforms di |
| G3483 |
APC Anti-CD5 (53-7.3) mAb |
CD5 is a 67 kDa human T-lymphocyte single-chain transmembrane glycoprotein. CD5 is present on all mature T-lymphocytes, on most of thymocytes and on many T-cell leukemias and lymphomas. CD5 also reacts with a subpopulation of activated B-cells and may act as a receptor in regulating T-cell proliferation. CD5 is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. CD5 is expressed by many T cell leukemia, lymphomas, and activated T cells. Diseases associated with CD5 dysfunction include thymus cancer and Richter's Syndrome. |
| G1893 |
APC Anti-CD51/Integrin αV (RMV-7) mAb |
ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8, 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands, the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. The ITGB3 protein product is the in |
| G0243 |
APC Anti-CD62L/L-Selectin (MEL-14) mAb |
The human CD62L is a 74-95 kDa glycoprotein member of the selectin family of adhesion receptors. L-Selectin is comprised of an aminoterminal C-type lectin binding domain, an epidermal growth factor-like domain, two short consensus repeat (SCR) sequences homologous to those found in complement binding proteins, a short spacer region, a transmembrane region and a short cytoplasmic region. Human CD62L (L-Selectin) is constitutively expressed on all classes of leukocytes including lymphocytes (except a substantial population of memory T cells), monocytes and polymorphonuclear cells. |
| G0498 |
APC Anti-CD68 (FA-11) mAb |
CD68 is considered a pan-macrophage marker, predominantly expressed on the intracellular lysosomes of tissue macrophages/monocytes, including Kupffer cells, microglia, histiocytes and osteoclasts, and is expressed to a lesser extent by dendritic cells and peripheral blood granulocytes. CD68 is expressed by many tumor types including some B cell lymphomas, blastic NK lymphomas, melanomas, granulocytic (myeloid) sarcomas, hairy cell leukemias, and renal, urinary and pancreatic tumors, and can be used to demonstrate the presence/localization of macrophages. |
| G0213 |
APC Anti-CD80/B7-1 (16-10A1) mAb |
CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28, and of an inhibitory receptor CTLA-4 (CD152). Both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, and both molecules can also substitute for each other in this process. CD80 is rapidly induced on the surface of in vitro activated B cells, with Epstein Barr Virus (EBV) transformed B cell lines, with Burkitts lymphoma cell lines, with freshly isolated follicular B lymphoma cells, T cells, and monocytes. The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 and CTLA4 ligands of T cells. Diseases associated with CD80 dysfunct |
| H1743 |
APC Anti-CD88 (S5/1) mAb |
Mouse anti Human CD88 antibody, recognizes the C5a receptor (C5aR) CD88, which is predominantly expressed on cells of the myeloid lineage. It was raised against a synthetic peptide comprising the N-terminal extracellular domain of the C5aR (met1-Asn31) and has recently been shown to recognise the heptameric peptide (D15DKDTLD21). It has been shown to inhibit the binding of C5a to its receptor. |
| G0003 |
APC Anti-CD8a (53-6.7) mAb |
CD8 (Cluster of differentiation 8), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, plays an integral role in signal transduction, and T cell differentiation and activation. CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8alpha and CD8beta, where it functions as a co-receptor, along with T cell receptor (TCR), for major histocompatibilty complex class I (MHC-I) molecules; whereas its counterpart, CD4, acts as a co-receptor for MHC-II molecules. CD8 exists on the cell surface, where the CD8alpha chain is essential for binding to MHC-I. CD8 is also expressed on a subset of T cells, NK cells, monocytes and dendritic cells as disulfide-linked homodimers of CD8alpha. Ligation of MH |
| G0738 |
APC Anti-CD90.1/Thy-1.1 (HIS51) mAb |
CD90 (Thy 1) antigen is a GPI linked glycoprotein member of the Immunoglobulin super family. It is expressed in murine T cells, thymocytes, neural cells, Kupffer's cells and fibroblasts. Thy 1 may play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain. |
| G2628 |
APC Anti-CD93 (AA4.1) mAb |
CD93 (also known as AA4.1, C1qRp) is a cell-surface glycoprotein and type I membrane protein originally identified as a myeloid cell marker. Although previously considered a C1q receptor, CD93 is now recognized for its roles in intercellular adhesion and the clearance of apoptotic cells. Its intracellular tail interacts with moesin, linking CD93 to the cytoskeleton and cytoskeletal remodeling. |
| G2178 |
APC Anti-DYKDDDDK Tag (L5) mAb |
The DYKDDDDK tag is often used as a protein modification in order to simplify the labeling and detection of proteins.This unique amino acid sequence allows for specific antibody detection in western blotting, immunoprecipitation, and immunostaining techniques.Due to the short sequence, this modification is not likely to affect the structure or function of the modified proteins. |
| H0768 |
APC Anti-FCER1A (AER-37 (CRA1)) mAb |
Fc epsilon RI alpha, also known as FcεRIα, is a subunit of the high-affinity receptor for IgE, primarily expressed on mast cells and basophils. Its expression is upregulated by the presence of IgE. FcεRIα forms a tetrameric complex with one beta and two gamma subunits, which are essential for signal transduction. The beta and gamma subunits contain immunoreceptor tyrosine-based activation motifs (ITAMs). The FcεRI complex plays a crucial role in triggering IgE-mediated allergic reactions.
When allergen-bound IgE molecules bring together two or more high-affinity IgE receptors, it leads to the release of mediators such as histamine, which are responsible for allergy symptoms.
This process couples allergens and mast cells to initiate inflamma |
| G0753 |
APC Anti-FCER1A (MAR-1) mAb |
Fc epsilon RI alpha, also known as FceR1 alpha, is a subunit of the high-affinity receptor for IgE, primarily expressed on mast cells and basophils. Its expression is upregulated by the presence of IgE. Fc epsilon RI alpha forms a tetrameric complex with one beta and two gamma subunits, which are essential for signal transduction. The beta and gamma subunits contain immunoreceptor tyrosine-based activation motifs (ITAMs). The Fc epsilon RI complex plays a crucial role in triggering IgE-mediated allergic reactions. When allergen-bound IgE molecules bring together two or more high-affinity IgE receptors, it leads to the release of mediators such as histamine, which are responsible for allergy symptoms. This process couples allergens and mast |
| G0048 |
APC Anti-FOXP3 (PCH101) mAb |
FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-alle |
| H0393 |
APC Anti-Granzyme B (GB11) mAb |
Granzyme B is a member of the granzyme serine protease family, and is found in the granules of cytotoxic T cells and NK cells. Granzyme B has been described as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation, and CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells. Granzyme B is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. The receptor involved in this process has been identified as mannose 6-phosphate receptor which functions as a death receptor for Granzyme B during cytotoxic T cell-induced ap |
| G3738 |
APC Anti-HER2/ErbB2 (H24A7) mAb |
The ErbB2 (HER2) proto-oncogene encodes a 185 kDa transmembrane, receptor-like glycoprotein with intrinsic tyrosine kinase activity. While ErbB2 lacks an identified ligand, ErbB2 kinase activity can be activated in the absence of a ligand when overexpressed and through heteromeric associations with other ErbB family members. Amplification of the ErbB2 gene and overexpression of its product are detected in almost 40% of human breast cancers. Binding of the c-Cbl ubiquitin ligase to ErbB2 at Tyr1112 leads to ErbB2 poly-ubiquitination and enhances degradation of this kinase. ErbB2 is a key therapeutic target in the treatment of breast cancer and other carcinomas and targeting the regulation of ErbB2 degradation by the c-Cbl-regulated proteolyt |
| H1458 |
APC Anti-Human CD10 (HI10a) mAb |
CD10, also known as Neutral Endopeptidase (NEP), Enkephalinase, Atriopeptidase, and Neprilysin, is a 100 kDa type II transmembrane glycoprotein encoded by the MME (membrane metallo-endopeptidase) gene. CD10 has neutral endopeptidase activity and is also referred to as the Common Acute Lymphoblastic Leukemia Antigen (CALLA). It is expressed on a wide variety of normal and neoplastic cell types, including granulocytes, bone marrow stromal cells, a subset of B-cell progenitors, germinal center B cells, and fibroblasts. CD10 is a cell surface metalloendopeptidase that inactivates several signaling molecules, playing a significant regulatory role in the nervous, immune, and other systems. |
| H0453 |
APC Anti-Human CD107a (H4A3) mAb |
CD107a, also known as Lysosomal-associated membrane protein 1 (LAMP-1), is a ~110 kDa type I transmembrane protein that is heavily glycosylated and widely expressed by cells primarily on the luminal surface of their lysosomes. It is also expressed on the surface of activated platelets, activated lymphocytes, cytotoxic T cells and NK cells, and some tumor cell lines, including U937 and KG1a. LAMP-1 can serve as a ligand for E-selectin-mediated cell adhesion. LAMP-1 and LAMP-2 (CD107b) are carriers for poly-N-acetyllactosamines and are able to display sialyl Le[x] termini. |
| H0378 |
APC Anti-Human CD117 (104D2) mAb |
CD117 is a 145 kD protein tyrosine kinase also known as c-Kit. It is a receptor for stem cell factor or c-Kit ligand. CD117 is expressed on pluripotent hematopoietic progenitor cells (approximately 1-4% bone marrow cells), mast cells, and acute myeloid leukemia cells (AML). CD117 binding of c-Kit ligand induces phosphorylation of CD117 and stimulates proliferation and survival of primitive hematopoietic stem cells as well as erythroid-committed and granulo-monocytic committed cells. |
| H3318 |
APC Anti-Human CD11a (HI111) mAb |
This antibody specifically binds to CD11a, the 180 kDa integrin α chain. This type I transmembrane glycoprotein associates with CD18 (integrin β2) to form the heterodimeric glycoprotein CD11a/CD18. This heterodimer is also known as the lymphocyte (leukocytes) function associated antigen-1 (LFA-1) that is expressed on all leukocytes. LFA-1 is an adhesion molecule involved in lymphocyte and granulocyte functions. LFA-1 mediates adhesion of lymphoid cells to the vascular endothelium in association with its ligand, and the intracellular adhesion molecule-1 (ICAM-1), CD54. Other ligands are ICAM-2 (CD102) and ICAM-3 (CD50). Purified Mouse Anti-Human CD11a antibody also cross reacts with all leukocytes of baboon, and both rhesus and cynomolgus ma |
| H0078 |
APC Anti-Human CD11b (CBRM1/5) mAb |
CD11b, a 165-170 kDa type I transmembrane glycoprotein also known as αM integrin, Mac-1, CR3, and C3biR. CD11b non-covalently associates with integrin β2 (CD18) and is expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b/CD18 is critical for the transendothelial migration of monocytes and neutrophils as well as adhesion, phagocytosis, and neutrophil activation. CD11b/CD18 interacts with ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4, CD14, CD23, heparin, iC3b, fibrinogen and factor X. |
| H0063 |
APC Anti-Human CD11b (ICRF44) mAb |
CD11b is a 165-170 kD type I transmembrane glycoprotein also known as αM integrin, Mac-1, CR3, and C3biR. CD11b non-covalently associates with integrin β2 (CD18) and is expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b/CD18 is critical for the transendothelial migration of monocytes and neutrophils. It is also involved in granulocyte adhesion, phagocytosis, and neutrophil activation. CD11b/CD18 interacts with ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4, CD14, CD23, heparin, iC3b, fibrinogen, and factor X. |
| H0138 |
APC Anti-Human CD11c (3.9) mAb |
CD11c is a 145–150 kDa type I transmembrane glycoprotein also known as integrin αx and CR4. CD11c non-covalently associates with integrin β2 (CD18) and is expressed on monocytes/macrophages, dendritic cells, granulocytes, NK cells, and subsets of T and B cells. CD11c has been reported to play a role in adhesion and CTL killing through its interactions with fibrinogen, CD54, and iC3b. |
| H3333 |
APC Anti-Human CD13 (WM15) mAb |
CD13, also known as aminopeptidase N, is a 150 kDa type II integral membrane glycoprotein. It serves as the cellular receptor for human coronavirus 229E, which can cause upper respiratory tract infections. CD13 is expressed on GM-progenitor cells, granulocytic and monocytic cells, and mast cells, but is absent on lymphocytes, platelets, and erythrocytes. It plays a role in the metabolism of various regulatory peptides. |
| H3798 |
APC Anti-Human CD137 (4B4-1) mAb |
CD137 is a 39 kD transmembrane protein also known as 4-1BB. It is expressed on activated T cells. CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily. CD137 appears to be important for T cell proliferation and survival, and induces monocyte activation through its interaction with 4-1BB ligand. |
| H0183 |
APC Anti-Human CD14 (M5E2) mAb |
CD14 is a 53–55 kDa glycosylphosphatidylinositol (GPI)-anchored single-chain glycoprotein expressed at high levels on monocytes, macrophages, and neutrophils. CD14 is a multifunctional receptor and is constitutively expressed on the surface of mature monocytes and macrophages. It serves as a high-affinity receptor for lipopolysaccharide (LPS) and binds LPS in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute-phase serum protein. CD14 also exists in a soluble form (sCD14) and is released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. The soluble sCD14 is important for neutralizing allochthonous lipopolysaccharides by reconstituted lipoprotein particles and can discriminate structural dif |
| H1038 |
APC Anti-Human CD146 (P1H12) mAb |
CD146, also known as MCAM, MUC18, or Mel-CAM, is a 118 kDa transmembrane glycoprotein and a member of the immunoglobulin superfamily. It is strongly expressed by blood vessel endothelium and smooth muscle. CD146 is also found on angioblasts, mesenchymal stem cells, melanoma cells, intermediate trophoblasts, and a subset of activated T cells. CD146 is widely used as a marker for endothelial cells and plays a key role in studies of angiogenesis, cancer progression, and vascular biology. |
| H1353 |
APC Anti-Human CD152/CTLA-4 (BNI3) mAb |
CD152, also known as CTLA-4 (Cytolytic T Lymphocyte-Associated Antigen 4), is a molecule transiently expressed on activated CD28+ T cells. It binds to CD80 and CD86 on antigen-presenting cells (APCs) with high avidity, delivering a negative regulatory signal to the T cell. It has also been shown that CTLA-4 is expressed on B cells when cultured with activated T cells, indicating a role in regulating the B-cell response. Additionally, CD152 is expressed on regulatory T (Treg) cells. The BNI3 monoclonal antibody specifically binds to human CTLA-4 and can be used to study its role in T-cell proliferation and regulation.
|
| H1128 |
APC Anti-Human CD16 (3G8) mAb |
CD16a is a ~50–65 kDa type I transmembrane glycoprotein encoded by FCGR3A (Fc fragment of IgG receptor IIIa), which belongs to the immunoglobulin superfamily. CD16a is also known as Fc-gamma RIII-alpha (FcγRIIIA or FcRIIIa) and is expressed on natural killer (NK) cells, activated monocytes, macrophages, γδ T cells, immature thymocytes, and mast cells. CD16a binds immune-complexed or aggregated IgG and associates with CD247/TCRζ in NK cells and FcεRIγ chains in phagocytes and mast cells to transduce intracellular signals. CD16a functions in antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses including phagocytosis, cytokine production, or mediator release. CD16b is a ~48 kDa glycophosphatidylinositol (GPI)- |
| H3498 |
APC Anti-Human CD163 (GHI/61) mAb |
CD163 is also known as Scavenger receptor cysteine-rich type 1 protein M130 (M130), Hemoglobin scavenger receptor and Macrophage-associated antigen. CD163 is a 110-130 kDa transmembrane glycoprotein. CD163 is a monocyte/macrophage-restricted antigen expressed on the majority of tissue macrophages and peripheral blood monocytes. CD163 belongs to the scavenger receptor superfamily. Its expression on monocytes is upregulated upon cellular activation. CD163 expression reportedly changes on monocytes and macrophages as these cells differentiate. This finding suggests a role for this molecule in the differentiation and/or regulation of monocyte and macrophage function. CD163 may play a role in the clearance and endocytosis of hemoglobin and hapto |
| H2823 |
APC Anti-Human CD166/ALCAM (3A6) mAb |
CD166, also known as Activated Leukocyte Cell Adhesion Molecule (ALCAM) and the CD6 ligand, is a 100–105 kDa transmembrane glycoprotein belonging to the immunoglobulin superfamily. It consists of an immunoglobulin-like extracellular domain, a transmembrane region, and a short cytoplasmic tail. CD166 is expressed on neurons, activated T cells, activated monocytes, epithelial cells, and fibroblasts. It plays a key role in mediating adhesion interactions, particularly between thymic epithelial cells and CD6+ cells during intrathymic T-cell development. |
| H0003 |
APC Anti-Human CD19 (HIB19) mAb |
CD19 is a 95 kDa type I transmembrane glycoprotein expressed during all stages of B-cell maturation and differentiation, except on plasma cells. It is also present on follicular dendritic cells but not found on T cells or normal granulocytes. CD19 functions as a signal transduction molecule that regulates B cell development, activation, proliferation, and differentiation. It associates with complement receptor 2 (CD21), TAPA-1 (CD81), Leu 13, and/or MHC class II to form a signal transduction complex on the surface of B cells.
|
| H0018 |
APC Anti-Human CD19 (LT19) mAb |
CD19 is a type I transmembrane glycoprotein of 95 kDa that belongs to the immunglobulin superfamily. CD19 is expressed on B cells throughout most stages of B cell differentiation, though its expression is down-regulated during their terminal differentiation to plasma cells. Expression of CD19 is also found in the majority of B cell–derived malignancies. CD19 is further present on follicular dendritic cells. On B cells, CD19 associates with CD21, CD81, and CD225 (Leu-13) forming a signal transduction complex. |
| H1023 |
APC Anti-Human CD195 (2D7/CCR5) mAb |
CCR5, also known as CD195, is a seven transmembrane-spanning G protein-coupled receptor (GPCR) that belongs to the beta chemokine receptor family. It is expressed on a subset of T lymphocytes (CD3⁺CD45RO⁺CD95⁺). CCR5 plays a key role in regulating lymphocyte chemotaxis, activation, and transendothelial migration during inflammation by responding to at least three chemokines: RANTES (Regulated upon Activation, Normal T-cell Expressed and Secreted), MIP-1 (Macrophage Inflammatory Protein-1), and MCP-2 (Monocyte Chemoattractant Protein 2). Additionally, CCR5 serves as a coreceptor for macrophage-tropic HIV-1 on CD4⁺ T cells, which is critical for viral entry and transmission. Individuals with partial (heterozygous) or complete (homozygous) del |
| H1578 |
APC Anti-Human CD1a (HI149) mAb |
CD1a is a type I transmembrane glycoprotein. The 49 kDa CD1a polypeptide is associated with β2-microglobulin. CD1a is expressed on cortical thymocytes, dendritic cells and Langerhans cells. CD1a has structural similarities to the MHC class I antigen, and plays a role in antigen presentation. |
| H1593 |
APC Anti-Human CD1c (L161) mAb |
CD1c, also known as R7 or M241, is a 43 kD member of the five CD1 antigens (CD1a-e) in humans. The CD1 molecules are type I glycoprotein with structural similarities to MHC class I and are non-covalently associated with β2-microglobulin, belonging to the Ig superfamily. CD1c is expressed on cortical thymocytes, Langerhans cells, dendritic cells, and a subset of B cells. It has been reported that CD1c is also expressed on mature T cells in a tightly regulated manner. CD1c is involved in antigen-presentation of glycolipids. It may also act in T cells as an immune regulatory molecule. |
| H1158 |
APC Anti-Human CD20 (2H7) mAb |
CD20 is a 33-37 kD, four transmembrane spanning protein, also known as B1 and Bp35. CD20 is expressed on pre-B-cells, resting and activated B cells (not plasma cells), some follicular dendritic cells, and at low levels on a T cell subset. CD20 is heavily phosphorylated on activated B cells and malignant B cells. Homo-oligomeric complexes of CD20 are thought to form Ca2+ conductive ion channels in the plasma membrane of B cells. The CD20 molecule is involved in B-cell activation and is associated with various Src family kinases (Lyn, Lck, Fyn). It exists in a complex with MHC class I and II, CD53, CD81, and CD82. |
| H1053 |
APC Anti-Human CD235a (GA-R2 (HIR2)) mAb |
CD235a is also known as Glycophorin A (GYPA, GPA, GLPA), Sialoglycoprotein alpha, MN sialoglycoprotein, or PAS-2. CD235b is also known as Glycophorin B (GYPB, GPB, GLPB), Sialoglycoprotein delta, SS-active sialoglycoprotein, or PAS-3. CD235a and CD235b are type I transmembrane sialoglycoproteins expressed on human erythrocytes, erythroid precursor cells, and certain leukemic cell types. CD235a carries blood group M and N antigens, whereas CD235b contains S, s, and U antigens. Glycophorins may play a role in preventing cell agglutination. The antibody against CD235a/b is useful for the identification and characterization of erythrocytes, certain myeloid leukemic cell types, and for studies of erythroid development and infectious diseases inv |
| H0318 |
APC Anti-Human CD24 (ML5) mAb |
CD24, also known as CD24A, signal transducer CD24, small cell lung carcinoma cluster 4 antigen, or BA-1, is a 35-70 kDa glycophosphatidylinositol (GPI)-linked glycoprotein. Its glycosylation pattern is highly variable and cell-type dependent. CD24 is expressed on neutrophils, eosinophils, dendritic cells, neural cells, epithelial cells, muscle cells, and many types of cancer cells. CD24 functions as an adhesion receptor. Several different ligands have been identified for CD24, including CD62P (P-selectin), which is expressed on activated platelets and activated endothelium. CD24 is variably expressed on all B lineage cells, except plasma cells, and can play a role in regulating the activation, proliferation, or differentiation of these cell |
| H4248 |
APC Anti-Human CD25 (M-A251) mAb |
The CD25 antigen is also known as the human low-affinity interleukin-2 receptor α chain (IL-2Rα) and the Tac antigen. The CD25antigen is present on a subset of peripheral blood lymphocytes. Antigen density increases on phytohemagglutinin (PHA)-, concanavalin A (Con A)-, and CD3-activated T lymphocytes; T lymphocytes from mixed lymphocyte cultures; and HTLV-infected T-lymphocyte leukemia lines, for example, HUT-102. Recombinant IL-2 blocks the binding of CD25 to PHA-activated T lymphocytes. CD4+/CD25+ regulatory T cells might directly regulate the function of responsive T cells. The CD25antibody is composed of mouse IgG1 heavy chains and kappa light chains |
| H4113 |
APC Anti-Human CD271/NGFR (ME20.4) mAb |
CD271, also known as p75NTR, TNFRSF16, p75(NTR), Gp80-LNGFR, and NGFR, is a type I transmembrane protein with a MW of 75 kD. It is expressed by many cell types including neurons, Schwann cells, mesenchymal stem/stromal cells, follicular dendritic cells and melanocytes. The extracellular portion contains four TNFR-Cys repeats that form the binding domain for its ligands (NGF, BDNF, NTF3, and NTF4). The intracellular portion of CD271 contains a death domain, which interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9, to promote cell apoptosis, and to regulate cell differentiation and neurogenesis. |
| H0438 |
APC Anti-Human CD279/PD-1 (EH12.2H7) mAb |
Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC) are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion. |
| H4098 |
APC Anti-Human CD28 (CD28.2) mAb |
CD28 is a 44 kDa homodimeric transmembrane glycoprotein expressed on most mature T cells, thymocytes, and plasma cells. It acts as a costimulatory receptor, binding to CD80 and CD86 ligands, and plays a crucial role in T cell-B cell interactions. CD28 is believed to initiate and regulate a distinct signal transduction pathway that is separate from those stimulated by the TCR complex. The binding of CD28 to its ligands can also influence immune responses, including the production of IL-2 and changes in intracellular calcium concentrations. |
| H0618 |
APC Anti-Human CD29/ITG-β1 (MAR4) mAb |
CD29 is a 130 kDa integrin β1 subunit that is expressed as a heterodimeric complex with one of six distinct α subunits, comprising the very late activation antigen (VLA) subfamily of adhesion receptors. The β1 subunit has a broad tissue distribution; it is expressed on lymphocytes, monocytes and weakly on granulocytes, but not on erythrocytes. These receptors are involved in a variety of cell-cell and cell-matrix interactions. |
| H1758 |
APC Anti-Human CD294/CRTH2 (BM16) mAb |
CD294, also known as CRTH2, is a seven-transmembrane protein coupled with heterotrimeric G proteins. CRTH2 is the prostaglandin D2 receptor and is expressed by Th2 cells, eosinophils, and basophils. CD294 prevents the apoptosis of Th2 cells and mediates the chemotaxis of CRTH2 expressing cells to the sites of allergic inflammation, such as the asthmatic lung. |
| H4278 |
APC Anti-Human CD3 (OKT-3) mAb |
CD3ε is one of five polypeptide chains that combine to form the TCR complex. CD3ε is expressed on T lymphocytes, NK-T cels, and to varying degrees on developing thymocytes. CD3 plays roles in TCR signaling, T lymphocyte activation, and antigen recognition. |
| H0228 |
APC Anti-Human CD31 (WM59) mAb |
CD31 (PECAM-1), also known as GPIIA' or EndoCAM, is a 130 kDa type I transmembrane glycoprotein belonging to the Ig gene superfamily. It is widely expressed on platelets, monocytes, granulocytes, NK cells, T cell subsets, and in high amounts on endothelial cells. CD31 functions as a vascular endothelial cell adhesion molecule, playing a critical role in the transendothelial migration of leukocytes during inflammatory responses. It is also involved in thrombosis, angiogenesis, and wound healing. The antibody against PECAM-1 binds to an epitope near extracellular domain 2 of CD31.
Clone WM59 also cross-reacts with peripheral blood platelets and leukocytes of baboon, and both rhesus and cynomolgus macaque monkeys. The staining intensity of WM5 |
| H1398 |
APC Anti-Human CD314/NKG2D (1D11) mAb |
CD314, also known as NKG2D or KLRK1, is a 42 kDa type II transmembrane glycoprotein and a member of the C-type lectin family. It is expressed on human NK cells, as well as on virtually all TCR γ/δ+ and CD8+ TCR α/β+ T cells. NKG2D functions as an activating receptor that binds strongly to several ligands, including MICA, MICB, and ULBP-1, -2, and -3, which are expressed by different target cell types. Unlike other natural cytotoxicity receptors (NCR), NKG2D is not restricted to NK cells. It plays a critical role in natural cytotoxicity, aiding normal NK cells in attacking a variety of tumor or normal target cells. NKG2D can complement the role of NCR in tumor cell lysis, and combined masking of both NCR and NKG2D can lead to a complete inhi |
| H0918 |
APC Anti-Human CD33 (WM53) mAb |
CD33, also known as Sialic acid-binding Ig-like lectin 3 (Siglec-3), gp67, or p67, is a 67 kDa type I transmembrane glycoprotein expressed on monocytes, activated T cells, myeloid progenitors, and mast cells. CD33 is absent on normal platelets, lymphocytes, erythrocytes, and hematopoietic stem cells. This glycoprotein can reportedly function as a sialic acid-dependent cell adhesion molecule. This function can be modulated by endogenous sialoglycoconjugates when CD33 is expressed on the membrane. |
| H0858 |
APC Anti-Human CD38 (HIT2) mAb |
The CD38 antigen is also known as T10, ADP-ribosyl cyclase 1, and cyclic ADP ribose hydrolase 1. CD38 is a 45 kDa type II single-chain transmembrane glycoprotein present on thymocytes, activated T cells, and terminally differentiated B cells (plasma cells). It is also expressed by monocytes, macrophages, dendritic cells, NK cells, myeloid and erythroid precursors, and some epithelial cells. CD38 functions as an ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose, a Ca²⁺-mobilizing second messenger. This intracellular calcium plays an important role in cell signaling pathways leading to cellular growth, apoptosis, and differentiation. CD38 binds to CD31, contributing to lymphocyte adhesion to endothelial cells. |
| H3378 |
APC Anti-Human CD39 (A1) mAb |
CD39 is an integral membrane protein with two transmembrane domains in humans. It exists as a homotetramer. Expression of CD39 is found on activated lymphocytes, a subset of T cells and B cells, and dendritic cells with weak staining on monocytes and granulocytes. CD39 and CD73 have been found on regulatory T cells, specifically the effector/memory like T cells. CD39 can hydrolyze both nucleoside triphosphates and diphosphates. CD39 is the dominant ecto nucleotidase of vascular and placental trophoblastic tissues and appears to modulate the functional expression of type 2 purinergic (P2) G protein coupled receptors (GPCRs). CD39 has intrinsic ecto-ATPase activity. Expression of CD39 is induced on T cells and increased on B cells as a late a |
| H0048 |
APC Anti-Human CD4 (L200) mAb |
CD4 is a 56 kDa transmembrane glycoprotein expressed on the T-helper/inducer subset of peripheral blood lymphocytes in humans. It is primarily found on CD3-positive, CD8-negative T cells and does not react with B- or NK-cell markers. In baboons, CD4 is expressed on lymphocytes and weakly on monocytes. The distribution of CD4 on lymphocytes is similar between humans and these non-human primates. |
| H0033 |
APC Anti-Human CD4 (RPA-T4) mAb |
CD4 is a 56 kDa transmembrane glycoprotein expressed on the T-helper/inducer subset of normal human peripheral blood lymphocytes. The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex |
| H0558 |
APC Anti-Human CD40 (5C3) mAb |
CD40 is a 45–48 kDa type I transmembrane glycoprotein primarily expressed on B lymphocytes, though it is absent on terminally differentiated B cells. It is also found on endothelial cells, basal epithelial cells, certain epithelial cell carcinomas, follicular dendritic cells, macrophages, fibroblasts, keratinocytes, and CD34+ hematopoietic progenitor cells. CD40 plays a critical role in B-cell growth, proliferation, and differentiation, including immunoglobulin isotype switching. Engagement of CD40, particularly in the presence of IL-4 or costimulation with anti-µ or anti-CD20 antibodies, can promote B-cell proliferation.
|
| H0888 |
APC Anti-Human CD41a (HIP8) mAb |
CD41a, also known as Integrin αIIb or Platelet GPIIb, forms a calcium-dependent complex with CD61 (β3 integrin or GPIIIa) that is normally expressed on platelets and megakaryocytes. The CD41/CD61 complex serves as a receptor for fibrinogen, fibronectin, and von Willebrand factor, mediating platelet adhesion and aggregation. Blocking CD41 can completely inhibit ADP-, epinephrine-, and collagen-induced platelet activation, and partially inhibit ristocetin- and thrombin-induced activation. |
| H4038 |
APC Anti-Human CD42b (HIP1) mAb |
CD42b is also known as the Platelet glycoprotein Ib alpha chain that is encoded by the GP1BA gene. CD42b is disulfide bonded to CD42c to form a 170 kDa heterodimer, GPIb. GPIb forms a noncovalent complex with CD42a and CD42d (CD42 complex) that is expressed on platelets and megakaryocytes. The CD42 complex serves as the von Willebrand Factor (vWF) surface receptor involved in the adhesion of platelets to the subendothelium of damaged vascular walls. This antibody inhibits the ristocetin-dependent binding of vWF to platelets and partially inhibits collagen-induced aggregation. |
| H0093 |
APC Anti-Human CD45 (HI30) mAb |
CD45 is encoded by the PTPRC (Protein tyrosine phosphatase receptor type C) gene. CD45, also known as the leukocyte common antigen (LCA), is a member of the protein tyrosine phosphatase (PTP) family. It is present on all human leukocytes including lymphocytes, monocytes, granulocytes, eosinophils, and thymocytes. CD45 is absent from circulating erythrocytes, platelets, or mature erythroid cells of bone marrow and non-hemopoietic tissues. |
| H0738 |
APC Anti-Human CD45RA (HI100) mAb |
CD45RA, a 220 kDa isoform of the human leukocyte common antigen, is expressed on approximately 40–50% of peripheral CD4+ T cells, 50% of peripheral CD8+ T cells, and on a portion of B cells and monocytes. The CD45RA antigen is expressed by naïve and activated T cells. CD45RA-specific antibodies are useful for the study of the suppressor/inducer subpopulation of CD4+ lymphocytes. |
| H4008 |
APC Anti-Human CD45RO (UCHL1) mAb |
CD45RO is a 180 kDa isoform of the CD45 molecule, also known as the Leukocyte Common Antigen. It is a type I transmembrane glycoprotein with cytoplasmic protein tyrosine phosphatase activity involved in signal transduction. Unlike other CD45 isoforms, CD45RO lacks the amino acid sequences encoded by the variable exons A, B, and C. It is expressed on most thymocytes, activated T cells, memory T cells, granulocytes, and monocytes, and on a subset of resting T cells. CD45RO and CD45RA mark largely distinct populations within resting peripheral T cells, demonstrating functional and phenotypic heterogeneity within CD4 and CD8 T cell subsets. CD45RO also interacts with CD22. |
| H0528 |
APC Anti-Human CD49f (GoH3) mAb |
CD49f, also known as the integrin α6 chain, is a ~150 kDa type I transmembrane glycoprotein that belongs to the integrin alpha chain family of extracellular matrix and cell adhesion receptors. The integrin α6 subunit associates with the integrin β1 chain (CD29) to form VLA-6, and with the integrin β4 chain (CD104) to form the integrin α6β4 complex, also known as the laminin and kalinin receptor. CD49f is expressed mainly on T cells, monocytes, platelets, epithelial cells, endothelial cells, perineural cells, and trophoblasts of the placenta. Antibodies against CD49f can block the binding of integrin α6 to laminin P1 and E8 fragments. |
| H3978 |
APC Anti-Human CD5 (UCHT2) mAb |
CD5, also known as Leu-1, Ly-1 and T1, is a 67 kD single chain type I glycoprotein that is a member of the scavenger receptor superfamily. CD5 is expressed on T cells, thymocytes, B cell subsets, chronic B lymphocytic leukemia (B-CLL), and peripheral blood dendritic cells. CD5 modulates T and B cell receptor signaling, thymocyte maturation, and T-B cell interactions. One of its ligands is CD72. |
| H1248 |
APC Anti-Human CD54 (HA58) mAb |
CD54, also known as Intercellular Adhesion Molecule 1 (ICAM-1), is an 85-110 kDa type I transmembrane glycoprotein that belongs to the immunoglobulin supergene family. A soluble form of CD54 can also be found in biological fluids. CD54 is expressed on endothelial cells, as well as on both resting (weak) and activated (moderate) lymphocytes and monocytes. It serves as a ligand for LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). The CD54 adhesion molecule plays a key role in inflammatory and immune responses, as well as in neoplasia. |
| H4263 |
APC Anti-Human CD56/NCAM-1 (B159) mAb |
CD56 is a heavily glycosylated adhesion protein that is present on a subpopulation of peripheral blood large granular lymphocytes that demonstrate natural killer activity. CD56 is also expressed on a subset of T cells but is not expressed on myeloid cells, erythrocytes or B cells. This antigen is a pan-NK-cell marker. CD56 is virtually identical to an isoform of the neural cell adhesion molecule (NCAM), a structure mediating homotypic and heterotypic cell-cell interactions. |
| H3963 |
APC Anti-Human CD61 (VI-PL2) mAb |
CD61 is a 105 kDa transmembrane glycoprotein that is also known as integrin β3 and platelet glycoprotein IIIa (GPIIIa or GP3A). It is expressed on platelets, megakaryocytes, osteoclasts and endothelia. Integrin β3 associates with gpIIa (CD41) to form the CD41/CD61 complex which mediates platelet adhesion and aggregation. CD61 also associates with CD51 to form the CD51/CD61 complex (vitronectin receptor). CD61 appears to bind to fibrinogen, fibronectin, vWF, vitronectin, and thrombospondin to mediate cell adhesion. |
| H0288 |
APC Anti-Human CD62L (DREG-56) mAb |
CD62L (L-selectin) is a cell surface glycoprotein expressed on neutrophils, monocytes, T- and B-lymphocyte subsets, and NK cells. CD62L functions as a lymphocyte homing receptor, playing a key role in the migration of lymphocytes to peripheral lymph nodes via high endothelial venules (HEV). |
| H1323 |
APC Anti-Human CD63 (H5C6) mAb |
CD63 is a 53 kDa, type III lysosomal glycoprotein that belongs to the tetraspan transmembrane 4 superfamily (TM4SF). It is expressed on activated platelets, monocytes, and macrophages, and is also known by several other names, including LIMP, gp55, melanoma-associated antigen ME491, Pltgp40, and LAMP-3. CD63 is widely expressed on the surface and in the cytoplasm of various hematopoietic cells (such as monocytes and macrophages) as well as non-hematopoietic cells (including endothelium, fibroblasts, osteoclasts, and smooth muscle cells). It plays a key role in mediating cellular adhesion and motility. |
| H0513 |
APC Anti-Human CD68 (Y1/82A) mAb |
CD68, also known as Scavenger receptor class D member 1 (SCARD1), Macrosialin, or GP110, is a 110 kDa type I transmembrane glycoprotein primarily localized in cytoplasmic granules of monocytes, macrophages, dendritic cells, granulocytes, myeloid progenitor cells, and reportedly, a subset of CD34-positive hematopoietic bone marrow progenitor cells. CD68 belongs to the sialomucin family and functions as a scavenger receptor, capable of binding and internalizing oxidized low-density lipoproteins (LDL). Antibodies targeting CD68 are commonly used in studies of myeloid cell development and function. |
| H3933 |
APC Anti-Human CD71 (M-A712) mAb |
This antibody specifically binds to CD71 which is also known as the transferrin receptor (TFR). This type II transmembrane glycoprotein is expressed on cells as a disulfide-linked homodimer comprised of 95 kDa monomers. CD71 is expressed on activated lymphocytes, monocytes, macrophages, erythroid progenitors, brain endothelium, and most proliferating cells. CD71 is not expressed on resting lymphocytes and is upregulated during lymphocyte responses to antigens or mitogens. Through an endocytic pathway, the transferrin receptor mediates cellular iron uptake by binding and internalizing iron that is bound to transferrin. After releasing iron within the low pH endosomal environment, transferrin and its receptor can be recycled to the cell surfa |
| H0363 |
APC Anti-Human CD73 (AD2) mAb |
CD73, also known as ecto-5'-nucleotidase, is a 70 kDa, glycosyl phosphatidylinositol (GPI)-anchored glycoprotein. CD73 is expressed on subsets of T and B lymphocytes, follicular dendritic cells, epithelial cells, endothelial cells and mesenchymal stem cells. Its expression on lymphocytes increases during T and B cell development. CD73 has enzymatic activity and catalyzes the dephosphorylation of adenosine monophosphate (AMP), converting it to adenosine. It has been suggested that CD73 can mediate costimulatory signals in T cell activation and adhesion of lymphocytes to endothelium. |
| H0543 |
APC Anti-Human CD8 (SK1) mAb |
CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck. |
| H2418 |
APC Anti-Human CD81 (JS-81) mAb |
CD81 is an ~26 kDa transmembrane protein that belongs to the tetraspanin (TM4SF) family. It is involved in cell growth and signal transduction. CD81 has a very broad cellular distribution, being expressed on cells of hematopoietic, neuroectodermal and mesenchymal origin. In hematopoietic cells, the CD81 antigen is expressed on B and T lymphocytes, NK cells, thymocytes, eosinophils, germinal center follicular dendritic cells, and to a variable extent on monocytes. The CD81 antigen is not expressed on neutrophils, platelets, or erythrocytes. CD81-specific antibodies have been shown to have anti-proliferative effects on different lymphoid cell lines, particularly those derived from large cell lymphomas. They are also reported to induce homotyp |
| H1473 |
APC Anti-Human CD83 (HB15e) mAb |
CD83 is a 45 kDa type I transmembrane glycoprotein that belongs to the immunoglobulin (Ig) superfamily. It is composed of a single V-type Ig extracellular domain and a C-terminal cytoplasmic tail. CD83 is primarily expressed on the surface of follicular dendritic cells, circulating dendritic cells, interdigitating dendritic cells in lymphoid tissues, in vitro-generated dendritic cells, and thymic dendritic cells. However, its expression is not limited to dendritic cells; it is also found on some germinal center B cells and certain lymphoblastoid cell lines. While the exact function of CD83 is not fully understood, it is believed to play a role in cell-cell interactions during antigen presentation. |
| H0303 |
APC Anti-Human CD90(P15F7) mAb |
CD90, also known as Thy-1, is a 25-35 kDa glycophosphatidylinositol-anchored membrane glycoprotein of the Ig superfamily. It is expressed on 1-4% of human fetal liver cells, cord blood cells, and bone marrow cells. CD90 is present on a subset of immature CD34+ cells and a distinct subset of mature CD34- cells that are CD3+CD4+. The CD90+CD34+ population is highly enriched for cells capable of long-term culture. The anti-CD90 antibody is useful for enriching high proliferative potential colony-forming cells (HIPP-CFC), which are primitive progenitor cells. |
| H0468 |
APC Anti-Human HLA (G46-6) mAb |
HLA-DR, a major histocompatibility complex (MHC) class II antigen, is encoded by genes within the Human Leukocyte Antigen (HLA) Complex located on chromosome 6. HLA-DR is a transmembrane heterodimeric glycoprotein composed of an α chain (36 kDa) and a β subunit (27 kDa) expressed primarily on antigen presenting cells including B cells, dendritic cells, monocytes, macrophages, Langerhans cells, and thymic epithelial cells. HLA-DR is also expressed on activated T cells. This molecule plays a major role in mediating cellular interactions during antigen presentation to CD4-positive T cells. |
| H1788 |
APC Anti-Human HLA-A2 (BB7.2) mAb |
HLA-A2 is a class I molecule of the major histocompatibility complex (MHC) and part of the highly polymorphic group of cell-surface proteins encoded by the MHC gene locus. It plays a crucial role in the immune response by binding and presenting small antigenic protein fragments to antigen-specific receptors on T cells (TCR). Class I MHC molecules, like HLA-A2, bind peptides derived from intracellular antigens, such as viral and some bacterial antigens, which are recognized by CD8+ T cells. The TCRs recognize these processed peptides bound to the MHC, as well as regions of the MHC molecule itself, while CD4 and CD8 accessory molecules enhance the interaction by binding non-polymorphic regions of the MHC. |
| H3693 |
APC Anti-Human IgD (IA6-2) mAb |
IgD is a member of the immunoglobulin superfamily that exists in type 1-membrane (mIgD) and soluble glycoprotein forms. mIgD is expressed on mature naïve B cells (along with membrane IgM) and serves as a B-cell receptor for antigen (BCR). In response to antigen binding, the mIgD BCR, in association with other signaling molecules including CD79a and CD79b, can transduce activating or tolerizing signals intracellularly into B lymphocytes. |
| H1008 |
APC Anti-Human IgM (MHM-88) mAb |
IgM is the first immunoglobulin made by B cells in the immune response. Surface IgM is expressed on immature and mature B cells, while IgM heavy (μ) chain is expressed intracellularly in pre-B cells. |
| H1218 |
APC Anti-Human IL-2 (MQ1-17H12) mAb |
Interleukin-2 (IL-2) is a key cytokine involved in immune response and tolerance. It is produced by activated T cells and plays a crucial role in the activation, growth, proliferation, and differentiation of various immune cells, including T and B lymphocytes, LAK cells, NK cells, and monocytes/macrophages. IL-2 exerts its effects through binding to IL-2 receptor complexes, which include the intermediate-affinity IL-2R (comprising IL-2Rβ and γc) and the high-affinity IL-2R (which also includes IL-2Rα, along with IL-2Rβ and γc). IL-2 is essential for the proper functioning of the immune system, particularly in promoting T cell expansion and immune responses. |
| H2628 |
APC Anti-Human NKB1 (DX9) mAb |
CD158e1 functions as a killer cell inhibitory receptor (KIR) and is encoded by KIR3DL1 (Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail). CD158e1 is a 70 kDa glycoprotein that belongs to the Ig superfamily. It is expressed on a subset of natural killer cells and a small subset of T cells. Expression of CD158e1 has been observed to vary among individuals. KIR molecules specifically recognize a certain group of HLA class I antigens. Interaction of CD158e1 with specific HLA-B antigen on a target cell appears to inhibit cell-mediated cytotoxicity by delivering a negative signal that prevents lymphocyte activation. It is suggested that this MHC class I-KIR interaction works as a signaling mechanism that regulates |
| H4293 |
APC Anti-Human PD-L1 (29E.2A3) mAb |
PD-L1 is a 40 kDa type I transmembrane protein that belongs to the B7 family of the Ig superfamily. PD-L1 is expressed on T lymphocytes, B lymphocytes, NK cels, dendritic cels, as wel as IFNγ stimulated monocytes, epithelial cels and endothelial cels. PD-L1 binds to its receptor, PD-1, found on CD4 and CD8 thymocytes as wel as activated T and B lymphocytes and myeloid cels. Engagement of PD-L1 with PD-1 leads to inhibition of TCR-mediated T cel proliferation and cytokine production. PD-L1 is thought to play an important role in tumor immune evasion. Induced PD-L1 expression is common in many tumors and results in increased resistance of tumor cels to CD8 T cel mediated lysis. |
| H1848 |
APC Anti-Human TCR Vα7.2 (3C10) mAb |
The antibody recognizes the Vα7.2 T cell antigen receptor (TCR) α-chain segment which, joined with the Jα33 segment, constitutes an invariant TCR that is a characteristic of the mucosalassociated invariant T cells (MAIT cells). MAIT cells are restricted by a nonpolymorphic class Ib major histocompatibility complex (MHC) molecule, MHC-related molecule 1 (MR1). MAIT cells are present in human blood (1-8% of T cells), mesenteric lymph nodes, liver, and intestinal mucosa. MAIT cells play a role in detecting and fighting off microbial infections |
| H1488 |
APC Anti-Human TCR α/β (IP26) mAb |
TCR α/β is a monomorphic determinant of the α/β T-cell receptor, which is expressed on over 95% of normal peripheral blood CD3+ T cells. The α/β T-cell receptor (TCR) plays a crucial role in recognizing peptides bound to MHC molecules, leading to T-cell activation. |
| H0603 |
APC Anti-Human VEGFR2/KDR/Flk-1 (89106) mAb |
VEGFR2 (KDR/Flk-1), VEGFR1 (Flt-1), and VEGFR3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domains and kinase insert domains in their intracellular regions. The expression of VEGFR1, 2, and 3 is almost exclusively restricted to the endothelial cells. These receptors are likely to play essential roles in vasculogenesis and angiogenesis. VEGFR2 cDNA encodes a 1356 amino acid (aa) residue precursor protein with a 19 aa residue signal peptide. Mature VEGFR2 is composed of a 745 aa residue extracellular domain, a 25 aa residue transmembrane domain and a 567 aa residue cytoplasmic domain. In contrast to VEGFR1 which binds both P |
| G1593 |
APC Anti-Human/Mouse Integrin β7 (FIB504) mAb |
Integrin β7 is a 130 kD glycoprotein also known as integin βp. It is a member of the Ig superfamily. In association with integrin α4 or αE chain, β7 forms α4/β7 or αE/β7 heterodimer. α4/β7 (CD49d/β7, LPAM-1) is expressed on the majority of peripheral lymphocytes, on small subsets of thymocytes, and bone marrow progenitors. LPAM-1 binds to several ligands, VCAM-1, MAdCAM-1 and fibronectin, and is involved in lymphocyte adhesion and some hematopoietic progenitor cells migration. αE/β7 (CD103/β7,αIEL/β7) is expressed on intestinal intraepithelial lymphocytes (IEL), dendritic epidermal T cells, T regulatory cells, a subset of CD8+ T cells in lymph nodes and lamina propria. CD103/β7 complex is thought to play a role in lymphocyte retention via i |
| G0948 |
APC Anti-IgM (II/41) mAb |
Mouse IgM is an immunoglobulin M antibody that is produced by B cells in response to an antigen. It is the first antibody produced during an immune response and is the largest immunoglobulin in the serum. Mouse IgM is composed of five heavy chains and five light chains, and it is involved in complement activation and agglutination of antigens. It plays a crucial role in the innate immune response and is important for neutralizing pathogens before the adaptive immune response is fully activated. Mouse IgM is widely used in research and diagnostic applications, including ELISA, Western blotting, and immunohistochemistry. |
| G0318 |
APC Anti-Ki-67 (SolA15) mAb |
Ki-67 is a nuclear protein that is expressed during various stages in the cell cycle, particularly during late G1, S, G2, and M phases. The protein has a forkhead associated domain (FHA) through which it associates with euchromatin at the perichromosomal layer, the centromeric heterochromatin, and the nucleolus. Ki-67 is shown to have a cell cycle dependent topographical distribution with perinucleolar expression at G1, expression in the nuclear matrix at G2, and expression on the chromosomes during M phase. Ki-67 is commonly used as a proliferation marker because it is not detected in G0 cells, but increases steadily from G1 through mitosis. Ki-67 antibodies are useful in establishing the cell growing fraction in neoplasms. In neoplastic t |
| G0363 |
APC Anti-Ly-6A/E/Sca-1 (D7) mAb |
Stem Cell Antigen-1 (Sca-1) is a member of the lymphocyte antigen 6 (Ly-6) family. It is expressed on multipotent hematopoietic stem cells (HSC) and is used as a marker of HSC in mice. Sca-1 is used in combination with lineage depletion antibodies to identify murine HSC. Sca-1 can be found in fetal liver, adult bone marrow, and adult peripheral blood and spleen. Sca-1 may be involved in the regulation of B and T cell activation. |
| G0438 |
APC Anti-Mouse CD107a (1D4B) mAb |
CD107a, also known as Lysosome-Associated Membrane Protein 1 (LAMP-1), is a type I transmembrane glycoprotein that serves as a key marker of lysosomes. It is composed of a 40 kDa core protein that is heavily glycosylated, resulting in a mature glycoprotein ranging from 110 to 140 kDa. CD107a is predominantly expressed in epithelial cells and macrophages across various organs. Upon cellular activation, it translocates to the cell surface of lymphocytes, macrophages, epithelial cells, endothelial cells, platelets, and tumor cells. Surface expression of CD107a is involved in intercellular and extracellular matrix adhesion and is widely used as a functional marker of cytotoxic activity in NK cells and CD8+ T cells, as well as in identifying som |
| G4113 |
APC Anti-Mouse CD138 (281-2) mAb |
CD138 (Syndecan-1) is a transmembrane proteoglycan containing both heparan sulfate and chondroitin sulfate chains. It binds to components of the extracellular matrix and plays a critical role in cell adhesion, proliferation, and signaling. CD138 is predominantly expressed on epithelial cells, where its presence is associated with normal epithelial architecture. It is also expressed on B lymphocytes during specific stages of differentiation, including precursor B cells in the bone marrow and antibody-secreting plasma cells, but is absent on mature peripheral B cells. This expression pattern implicates CD138 in B cell–matrix interactions. Its expression is regulated during embryonic development and is subject to tissue-specific structural pol |
| G0978 |
APC Anti-Mouse CD146 (ME-9F1) mAb |
CD146, also known as melanoma cell adhesion molecule (MCAM or Mel-CAM), MUC18, S-Endo1, and A32 antigen, is an integral membrane glycoprotein that belongs to the Ig superfamily. CD146 is strongly expressed by murine vascular endothelial cells. It is expressed on about 30% of neutrophils and 60% of NK cells. Unlike in humans, CD146 is undetectable on monocytes, dendritic cells, T cells, NKT cells, B cells, or smooth muscle cells in mouse. It has been reported that an increase in CD146 expression is associated with NK cell maturation. Combined with using CD27 and CD11b staining, CD146 may be an alternative marker to detect final stages of NK cell maturation and define NK cell subsets. CD146+ NK cells were found to be less cytotoxic and to pro |
| G0648 |
APC Anti-Mouse CD150/SLAM (TC15-12F12.2) mAb |
CD150 is a 75-95 kD member of the immunoglobulin superfamily, also known as SLAM (signaling lymphocyte activation molecule) or IPO-3. CD150, a single chain type I transmembrane molecule, is expressed on thymocytes, T cell subsets, B cells, dendritic cells, and endothelial cells. The expression is upregulated upon activation. CD150 expression has been shown to be maintained on Th1 but not Th2 clones. T regulatory cells express a relatively high level of CD150. Antibodies against CD150 have been shown to augment IFN-γ production by Th1 cells, especially when co-stimulated through the TCR. CD150 associates with the src homology 2-domain-containing protein tyrosine phosphatase SHP-2, and this association is thought to be involved in signal tran |
| G4233 |
APC Anti-Mouse CD16/CD32 (2.4G2) mAb |
CD16 and CD32 are expressed on B cells, monocytes/macrophages, NK cells, granulocytes, mast cells, and dendritic cells. These receptors bind to the Fc portion of antibody-antigen complexes and play a role in adaptive immune responses. |
| G1083 |
APC Anti-Mouse CD185 (2G8) mAb |
The Rat Anti-Mouse CD185 (CXCR5) monoclonal antibody specifically binds to the mouse C-X-C Chemokine Receptor type 5, CXCR5. CXCR5 is also known as CD185, BLR1, NLR and MDR15. CXCR5 is a seven-transmembrane, G-protein-coupled receptor that is specific for the CXC chemokine, CXCL13/BLC/BCA-1. The expression of CXCR5 has been detected in spleen, lymph nodes, tonsils, brain, bone marrow, T cells, B cells, cerebrum, cerebellum, hippcampus and pituitary. In mouse spleen, CXCR5 was strictly expressed by mature B cells and a small subset of T lymphocytes. CXCR5 plays a role in directing the migration of B and T cells to B cell follicles with the spleen and certain other lymphoid tissues. The immunogen used to generate 2G8 hybridoma was a recombina |
| G4383 |
APC Anti-Mouse CD19 (1D3) mAb |
CD19, a B lymphocyte-lineage differentiation antigen and a 95-kDa transmembrane glycoprotein, is a member of the immunoglobulin superfamily and is expressed throughout B-lymphocyte development from the pro-B cell stage through mature B cells. Terminally differentiated plasma cells do not express CD19. On mature B cells, CD19 associates with CD21 (CR-2) and CD81 (TAPA-1), forming a multimolecular complex that synergizes with surface immunoglobulin to promote cellular activation. Studies in CD19-deficient mice suggest that the level of CD19 expression influences the generation and maturation of B cells in both bone marrow and peripheral tissues. B-1 lineage B cells, also called CD5+ B cells, are drastically reduced or absent in CD19-deficient |
| G1353 |
APC Anti-Mouse CD194/CCR4 (2G12) mAb |
Mouse CCR4 cDNA contains 1531 bp, and encodes a protein of 360 amino acids that is 85% identical to human CCR4. CCR4 binds CCL17 (TARG) and CCL22 (MDC). Naïve T cells, bearing receptors for cutaneous antigens, become activated in skin-draining lymph nodes and express cutaneous lymphocyte antigen (CLA), which confers to these cells the capacity to migrate into the skin to exert their normal effector functions (1). CCR4 and CCR10 play an important role in the ligand-mediated recruitment of T cells into the skin in mice and humans, specifically with regards to tethering, firm adhesion, and subsequent extravasation to the site of injury (2,3). CCR4 is expressed in cutaneous regulatory T cells (Tregs). These cells are crucial for the induction a |
| G4068 |
APC Anti-Mouse CD206/MMR (C068C2) mAb |
CD206, also known as mannose receptor (MR), is a 175 kD type I membrane protein. It is a pattern recognition receptor (PRR) belonging to the C-type lectin superfamily. MR is expressed on macrophages, dendritic cells, Langerhans cells, and hepatic or lymphatic endothelial cells. MR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine through its C-type lectin-like carbohydrate recognition domains, sulfated carbohydrate antigens through its cysteine-rich domain, and collagens through its fibronectin type II domain. MR mediates endocytosis and phagocytosis as well as activation of macrophages and antigen presentation. It plays an important role in host defense and provides a link between innate and ada |
| G0813 |
APC Anti-Mouse CD21/CD35 (7G6) mAb |
This antibody recognizes an epitope shared by 145-150-kDa and 190-kDa complement receptor proteins, originally designated CR2 (CD21) and CR1 (CD35), respectively. In the mouse, CD21 and CD35 are expressed on the majority of peripheral B lymphocytes, on the majority of resident peritoneal macrophages and mast cells, on peripheral blood granulocytes after treatment with N-formyl-Met-Leu-Phe, and on follicular dendritic cells, but not on thymocytes, T cells, erythrocytes, or platelets. CD21 is a ligand-binding component of the CD19/CD21/CD81 signal-transduction complex associated with the antigen receptor on B lymphocytes. CD21/CD35 also co-localizes with CD19 on the surface of peritoneal mast cells. Cr2null mice display impaired inflammatory |
| G4203 |
APC Anti-Mouse CD25/IL-2Rα (PC61.5) mAb |
Interleukin-2 receptor alpha (IL-2Rα), also known as CD25, Ly-43, p55, or Tac, is the 55 kDa ligand-binding subunit of the interleukin-2 receptor. IL-2Rα is expressed on activated mature T and B lymphocytes, thymocyte subsets, pre-B cells, and T regulatory cells. IL-2Rα plays roles in lymphocyte differentiation, activation, and proliferation. Alone, IL-2Rα binds IL-2 with relatively low affinity; however, when IL-2Rα associates with IL-2Rβ (CD122) and the common gamma chain (CD132), the complex binds IL-2 with high affinity. |
| G1248 |
APC Anti-Mouse CD357/GITR (DTA-1) mAb |
CD357, also known as GITR (Glucocorticoid-induced Tumor Necrosis Factor Receptor family-Related), is a 66-70 kDa homodimer glycoprotein that belongs to the TNF receptor superfamily. It is also referred to as TNFRSF18. GITR expression was first identified in T lymphocytes treated with dexamethasone, a glucocorticoid. In normal naive mice, GITR is expressed at moderate levels on CD25-positive/CD4-positive/CD8a-negative thymocytes and on CD25-positive/CD4-positive/CD45RB-low splenocytes. It is also expressed at low levels on splenic CD25-negative/CD4-positive/CD45RB-low T lymphocytes, B lymphocytes, macrophages, and dendritic cells. GITR expression is upregulated upon activation of T and B lymphocytes. As a costimulatory receptor, GITR plays a |
| G0843 |
APC Anti-Mouse CD38 (90) mAb |
CD38 is a 45 kD type II transmembrane glycoprotein also known as T10. It is an ADP-ribosyl hydrolase expressed at variable levels on hematopoietic cells and in some non-hematopoietic tissues (such as brain, muscle, and kidney). In humans, it is expressed at high levels on plasma cells and activated T and B cells, natural killer (NK) lymphocytes, myeloblasts, and erythroblasts. By functioning as both a cyclase and a hydrolase, CD38 mediates lymphocyte activation, adhesion, and the metabolism of cADPR and NAADP. CD31 is the ligand of CD38. |
| G4158 |
APC Anti-Mouse CD3epsilon (145-2C11) mAb |
CD3epsilon is a 20 kDa transmembrane cell-surface protein that belongs to the immunoglobulin superfamily. It is one of five polypeptide chains that combine to form the T cell receptor (TCR) complex. CD3ε is expressed on T lymphocytes, NK-T cells, and to varying degrees on developing thymocytes. CD3 plays critical roles in TCR signaling, T lymphocyte activation, and antigen recognition.
|
| G4143 |
APC Anti-Mouse CD4 (GK1.5) mAb |
The CD4 antigen is a 55 kDa cell surface type I membrane glycoprotein belonging to the immunoglobulin superfamily. CD4 acts as a co-receptor which, in cooperation with the T cell receptor (TCR), interacts with class II MHC molecules displayed by antigen-presenting cells (APC). CD4 is expressed by the majority of thymocytes, most helper T cells, a subset of NK-T cells, and weakly by dendritic cells and macrophages. CD4 plays an important role in the development of T cells and is required for mature T cells to function optimally. |
| G0513 |
APC Anti-Mouse CD40 (1C10) mAb |
CD40 is a single-chain glycoprotein and a member of the tumor necrosis factor receptor (TNFR) family, exhibiting significant homology to the Hodgkin's disease-associated antigen, CD30. It is expressed by B lymphocytes, follicular dendritic cells, thymic epithelium, and a subset of peripheral T cells, as well as some epithelial cells, carcinomas, and lymphoid dendritic cells. Notably, CD40 is present on all B cells except plasma cells. CD40 plays a crucial role in regulating B cell development and maturation, inducing immunoglobulin isotype-switching, and protecting B cells from surface Ig-induced apoptosis when combined with other signals such as IL-4. It promotes proliferation and is essential for T cell-dependent immunoglobulin class swit |
| G0858 |
APC Anti-Mouse CD41 (MWReg30) mAb |
CD41 is a transmembrane glycoprotein that is encoded by Itga2b. CD41 associates with Integrin β3 chain (gpIIIa or CD61) to form the gpIIb/IIIa (CD41/CD61) complex. CD41/CD61 is expressed on platelets, megakaryocytes, and early hematopoietic progenitors. The integrin complex binds to fibrinogen, fibronectin, vitronectin, von Willebrand factor, and thrombospondin. It is important for platelet adhesion and aggregation, and it may play a role in osteolytic tumor metastasis. |
| G0528 |
APC Anti-Mouse CD49b (DX5) mAb |
CD49b is a 150 kDa transmembrane glycoprotein that non-covalently associates with CD29 (integrin β1) to form the integrin α2β1 complex known as VLA-2. The rat anti-mouse CD49b antibody has been reported to identify the majority of NK cells and a small T-cell subpopulation in most mouse strains (e.g., A/J, AKR, BALB/c, C3H/HeJ, C57BL/6, C57BL/10, C57BR, C58, CBA/Ca, DBA/1, DBA/2, SJL, SWR, 129/J, but not NOD). The DX5 antibody also recognizes platelets that express high levels of CD49b. |
| G0543 |
APC Anti-Mouse CD49b (HMα2) mAb |
CD49b is a 150 kD glycoprotein, also known as α2 integrin, VLA-2 α chain, Integrin α2 chain, and HMα2. It is a member of the integrin family, expressed on NK cells, a subset of splenic CD4+ T cells, NK-T cells, intestinal intraepithelial and lamina propria lymphocytes, epithelial cells, and platelets. By associating with CD29 (integrin β1 subunit), CD49b forms the VLA-2 (integrin α2β1 ) complex. It plays a critical role in both adhesion and lymphocyte activation. The primary ligands for CD49b are collagen, laminin, and fibronectin. |
| G1113 |
APC Anti-Mouse CD54 (YN1/1.7.4) mAb |
CD54 is a 90 kD immunoglobulin superfamily member also known as ICAM-1 and Ly-47. It is expressed on activated endothelial cells, high endothelial venules (HEV), T and B cells, monocytes/ macrophages, granulocytes, and dendritic cells. CD54 is an important intracellular adhesion molecule that participates in T cell-T cell, T cell-B cell, and T cell-target cell interactions via binding of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). CD54 has also been shown to be involved in lymphocyte trafficking, making it an important molecule in many immune reactions and inflammation. CD54 is also a receptor for rhinovirus. Antibodies against CD54 can block its interaction with LFA-1 and Mac-1, thereby inhibiting cell-cell adhesion, impairing antigen prese |
| G2943 |
APC Anti-Mouse CD64 (X54-5/7.1) mAb |
CD64 is a 72 kD single chain type I glycoprotein also known as FcγRI and FcRI. CD64 is a member of the immunoglobulin superfamily and is expressed on monocytes/macrophages, dendritic cells, and mast cells. The expression can be upregulated by IFN-γ stimulation. CD64 binds IgG immune complex. It plays a role in antigen capture, phagocytosis of IgG/antigen complexes, and antibody-dependent cellular cytotoxicity (ADCC). |
| G4413 |
APC Anti-Mouse CD86 (GL1) mAb |
CD86, along with CD80, is a member of the B7 family of costimulatory molecules and plays a crucial role in T cell activation and immune response regulation. CD86 is expressed at low levels on B cells, macrophages, and dendritic cells, and its expression is upregulated on B cells through various stimuli, including the BCR complex, CD40, and certain cytokine receptors. As a type I membrane protein and member of the immunoglobulin superfamily, CD86 serves as a ligand for the T cell surface proteins CD28 and CTLA-4 (CD152). The interaction between CD86 and CD28 provides a costimulatory signal essential for T cell activation during antigen presentation, while binding with CTLA-4 negatively regulates T cell activation, diminishing the immune resp |
| G1053 |
APC Anti-Mouse CX3CR1 (SA011F11) mAb |
CX3CR1 is a 40 kD, G-protein coupled receptor, with seven transmembrane regions. CX3CR1 is expressed by resident and alternatively activated macrophages (M2), a subset of monocytes, dendritic cells (DCs), NK cells, a subset of memory T cells, and mast cells. CX3CR1 is involved in cell recruitment during inflammation and participates in cell adhesion and extravasation from blood vessels. Its ligand is CX3CL1, also known as fractalkine or neurotactin. CX3CR1 is also a coreceptor for HIV1 and variations in this gene leads to increased susceptibility to HIV. In the brain, it is expressed by glial cells, which interact with CX3CL1 expressed by neurons. |
| G4368 |
APC Anti-Mouse CXCR3 (CXCR3-173) mAb |
CXCR3, also known as CD183, is a 38 kDa chemokine receptor for CXCL9 (MIG), CXCL10 (IP-10), and CXCL11 (ITAC). CXCR3 is expressed primarily on activated T cells, NK cells, as well as some epithelial and endothelial cells. CXCR3 mediates leukocyte trafficking. Binding of chemokine ligands to CXCR3 induces various cellular responses, including integrin activation, cytoskeletal changes, and chemotactic migration. An antibody targeting CXCR3 binds to the receptor and inhibits its interaction with CXCL10 and CXCL11, but not CXCL9.
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| G1803 |
APC Anti-Mouse H-2Kb (AF6-88.5) mAb |
H-2Kb is a mouse MHC class I alloantigen expressed on all nucleated cells of mice with the H-2^b haplotype. It plays a key role in presenting endogenous peptides to CD8+ T cells, enabling immune surveillance and cytotoxic T cell responses. |
| G0783 |
APC Anti-Mouse IL-10 (JES5-16E3) mAb |
IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. D |
| G4218 |
APC Anti-Mouse IL-4 (11B11) mAb |
IL-4 (interleukin-4) is a multifunctional 14 kDa cytokine. IL-4 is mainly produced by activated Th2 and NK cells, with smaller contributions from mast cells and basophils. It signals via the IL-4Rα receptor. Once bound to its receptor, IL-4 promotes the proliferation of activated B and T cells and drives B cell differentiation into plasma cells. It also facilitates class switching to IgE in B cells and enhances MHC class II expression, while suppressing Th1 cell development, macrophage activity, IFNγ production, and IL-12 release by dendritic cells. IL-4, like other cytokines associated with Th2 responses, contributes to airway inflammation commonly seen in allergic asthma. |
| G4578 |
APC Anti-Mouse IL-6R (15A7) mAb |
CD126, also known as IL-6R, is an 80 kDa type I cytokine receptor and a member of the immunoglobulin superfamily. CD126 is expressed by activated T and B lymphocytes, monocytes, hepatocytes, and plasma cells. The IL-6 receptor α chain binds IL-6 but requires association with gp130 to initiate signal transduction. Upon IL-6 binding, the IL-6R complex influences antigen-specific immune responses, inflammatory responses, neuronal development, and is a major mediator of the acute phase reaction. Antibodies against CD126 can block the binding of IL-6 to the IL-6 receptor. |
| G4308 |
APC Anti-Mouse LFA-1α/CD11a (M17/4) mAb |
LFA-1α (lymphocyte function-associated antigen 1 alpha), also known as integrin alpha L chain and CD11a, pairs with CD18 to form LFA-1, a 180 kDa integrin glycoprotein belonging to the integrin family. LFA-1 is expressed on the surface of all leukocytes, including lymphocytes, monocytes, macrophages, and granulocytes. It plays a central role in leukocyte intercellular adhesion through interactions with its ligands ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50), and also contributes to lymphocyte costimulatory signaling. |
| G4428 |
APC Anti-Mouse Ly6G (1A8) mAb |
Lymphocyte antigen 6 complex, locus G (Ly-6G), is a 21–25 kDa GPI-anchored protein expressed primarily on peripheral granulocytes and highly specific for neutrophils. Ly-6G serves as a robust marker for neutrophil identification and depletion in mice. Ly-6G modulates neutrophil migration and recruitment to sites of inflammation via interaction with β2 integrins. Its downregulation is associated with age-related functional decline in neutrophils. |
| G4248 |
APC Anti-Mouse NK1.1 (PK136) mAb |
NK1.1, also known as CD161b/CD161c, KLRB1, NKR-P1A, and Ly-55, is a type II integral membrane glycoprotein with a C-type lectin domain and is encoded by the Klrb1c/NKR-P1C gene. NK1.1 plays roles in NK cell activation and differentiation, IFN-γ production, cytotoxic granule release, and is thought to be involved in the generation of Th2 cells. NK1.1 is predominantly expressed as a disulfide-linked homodimer on NK cells; however, it is also expressed on NK-T cells, a rare population of T lymphocytes. NK1.1 is only expressed by C57BL/6, FVB/N, and NZB strains of mice and not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129 strains. |
| G4263 |
APC Anti-Mouse PD-L1 (10F.9G2) mAb |
PD-L1 (programmed death ligand 1), also known as B7-H1 or CD274, is a 40 kDa type I transmembrane protein that belongs to the B7 family of the immunoglobulin superfamily. PD-L1 is expressed on T lymphocytes, B lymphocytes, NK cells, dendritic cells, as well as IFNγ-stimulated monocytes, epithelial cells, and endothelial cells. PD-L1 binds to its receptor, PD-1, found on CD4 and CD8 thymocytes as well as activated T and B lymphocytes and myeloid cells. Engagement of PD-L1 with PD-1 leads to inhibition of TCR-mediated T cell proliferation and cytokine production. PD-L1 is thought to play an important role in tumor immune evasion. Induced PD-L1 expression is common in many tumors and results in increased resistance of tumor cells to CD8 T cell |
| G2553 |
APC Anti-Mouse Siglec H (551) mAb |
The Siglec-H is a member of CD33-related Siglec family which mostly expressed in the innate immune system. Siglec-H is reported to be specifically expressed on plasmacytoid dendritic cells. Siglec-H depends on adaptor protein DAP 12 (DNAX-activating protein of 12 kD) for surface expression and signal transduction. Cross-linking with this antibody can selectively inhibit interferon-alpha production by IPCs following TLR9 ligation. |
| G1668 |
APC Anti-Mouse TCR Vα2 (B20.1) mAb |
TCR Vα2 is a distinct T-cell receptor (TCR) subfamily found in mice with the a, b, and c haplotypes. The TCR α chain complexes with the TCR β chain in 95% of T cells, forming the T cell receptor (α/β TCR), while the remaining 5% of T cells express gamma (γ) and delta (δ) chains (γ/δ TCR). TCR Vα2 represents a specific variant of the TCR α chain that plays a role in antigen recognition and is useful in the study of T-cell function and immune responses in mice with these specific haplotypes. |
| G4353 |
APC Anti-Mouse Ter-119 (TER-119) mAb |
TER-119 is a lineage marker for erythroid cells from early proerythroblast to mature erythrocyte stages in adult blood, spleen, and bone marrow. It is also present in yolk sac, and fetal and newborn liver. The TER-119 antigen is not expressed by cells of earlier erythroid development at BFU-e (blast-forming unit erythroid) stage or CFU-e (colony-forming unit erythroid) stage. |
| G2028 |
APC Anti-Mouse/rat CD81 (Eat-2) mAb |
CD81 is a 26 kD non-glycosylated member of the tetraspanin superfamily (TM4SF), also known as TAPA-1. CD81 is expressed on T and B cells, NK cells, dendritic cells, thymocytes, endothelial cells, and fibroblasts. CD81 induces B cell adhesion via the VLA-4 integrin and has been shown to play a role in early T cell development. CD81 associates with several other cell-surface proteins in a multimolecular complex, including CD19, CD21, CD20, CD37, CD53, and CD82 in B cells, and CD4, CD8 and CD82 in T cells. |
| H4218 |
APC Anti-Neuron-specific beta-III Tubulin (TuJ-1) mAb |
β-III Tubulin, also known as tubulin β-4, is regarded as a neuron-specific marker. The expression of β-III Tubulin has been suggested to be one of the earliest markers to signal commitment in primitive neuroepithelium. |
| G1293 |
APC Anti-Podoplanin(L7B2) mAb |
Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin type-1 glycoprotein with a 40-43 kDa molecular weight. Podoplanin is expressed in many tumors and normal cells, especially lymphatic epithelial cells and follicular DCs. Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. Podoplanin appears to serve as a ligand for CLEC-2 and expression is positively correlated with tumors expressing greater invasive and metastatic potential. Podoplanin is directly involved in cell migration, aids metastases formation and tumor cell invasion of tissue. Further, it has also been determined that |
| G0588 |
APC Anti-RORgammat (AFKJS-9) mAb |
ROR gamma, a NR1 Thyroid Hormone-Like receptor, has been shown to affect thymopoiesis, bone metabolism, T-cell apoptosis, and lymphoid organogenesis. ROR gamma has been shown to promote thymocyte survival by activating the expression of the antiapoptotic protein Bcl-x(L). ROR gamma is also required for the development of lymph nodes and Peyer's patches. It has been shown that ROR gamma(t), a thymus-specific isoform of ROR gamma from mouse, inhibits Fas ligand expression and cytokine secretion in immature thymocytes. ROR gamma binds as a monomer to response elements composed of a single core motif, GGTCA, preceded by a 6 bp AT-rich sequence. ROR gamma expression has been documented in mouse thymus, adipose, bone, skeletal muscle, liver, and |
| G0618 |
APC Anti-T-bet(B2D24) mAb |
T-bet, also known as TBX21, is a T-cell specific transcription factor containing a single T-box DNA-binding domain. It controls the expression of the TH1 cytokine, interferon-gamma. Both Th1 and Th17 cells are crucial in immune regulation and autoimmune disease development. T-bet initiates Th1 lineage development from naive Th precursor cells and directs T cell differentiation to Th1 versus Th17. T-bet is cooperating with Stat4 (signal tranducer and activator of transcription 4) in programming chromatin architecture for Th1 gene expression. Genetic variations in T-bet are associated with susceptibility to aspirin-induced asthma and nasal polyps. |
| G4023 |
APC Anti-TCF1/TCF7 (E19C1) mAb |
LEF1 and TCF are members of the high mobility group (HMG) DNA-binding protein family of transcription factors that consists of the following: Lymphoid Enhancer Factor 1 (LEF1), T Cell Factor 1 (TCF1/TCF7), TCF3/TCF7L1, and TCF4/TCF7L2. LEF1 and TCF1/TCF7 were originally identified as important factors that regulate early lymphoid development and act downstream in Wnt signaling. LEF1 and TCF bind to Wnt response elements to provide docking sites for β-catenin, which translocates to the nucleus to promote the transcription of target genes upon activation of Wnt signaling. LEF1 and TCF are dynamically expressed during development and aberrant activation of the Wnt signaling pathway is involved in many types of cancers, including colon cancer. |
| G0918 |
APC Anti-TCR gammadelta(J18P6) mAb |
TCR gamma/delta (T-cell receptor gamma/delta) are specialized T-cells in the immune system. The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflamm |
| G0288 |
APC Anti-TCR-β (H57-597) mAb |
The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system c |
| G3423 |
APC Anti-TLR4/MD-2 Complex (MTS510) mAb |
MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e.g., human MD-2 transfected into mouse cells can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4. |
| H0348 |
APC Anti-TNF-α (MAb11) mAb |
TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is mainly secreted by macrophages and binds to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. It exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice suggested the neuroprotective function of TNF alpha, and it has been observed to cause tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to |
| G4188 |
APC Mouse IgG1 isotype control (MOPC-21) |
Mouse IgG1 isotype control is a mouse myeloma protein. It was selected as an isotype control following screening for low background on a variety of mouse and human tissues. |
| G4293 |
APC Rat IgG2a isotype control (2A3) |
Rat IgG2a isotype control antibodies are immunoglobulins that lack specificity for mammalian antigens. They serve as essential negative controls in immunological assays, helping to distinguish specific antibody binding from background or non-specific interactions in both in vivo and in vitro applications. |
| G0633 |
APC Rat IgG2a kappa Isotype Control (eBR2a) |
Rat IgG2a is an immunoglobulin subclass that is commonly used in research and diagnostic applications. It is produced by the rat immune system and is known for its ability to activate complement and mediate antibody-dependent cell-mediated cytotoxicity (ADCC). Rat IgG2a has a molecular weight of approximately 160 kDa and is composed of two heavy chains and two light chains. It is often used as a control or reference antibody in experiments involving rat models, and is also commonly used in flow cytometry and immunohistochemistry applications.
|
| G0888 |
APC Rat IgG2b kappa Isotype Control (eB149/10H5) |
Rat IgG2b is a protein-coding gene that encodes for the immunoglobulin G2b (IgG2b) subclass of rat antibodies. IgG2b is a major subclass of rat immunoglobulins that plays a crucial role in the immune response by neutralizing pathogens and promoting opsonization. Rat IgG2b is commonly used in research applications, such as in immunohistochemistry, flow cytometry, and Western blotting.
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| H0336 |
APC-Cy7 Anti-CD161 (HP-3G10) mAb |
CD161, also known as NKR-P1A, is a type II transmembrane lectin-like receptor and member of the killer cell lectin-like receptor (KLR) family. CD161 exists as a homodimer and is prominently expressed on natural killer (NK) and NKT cells, where it is proposed to regulate the function of both cell types. CD161 is also found on T cell subsets, including T regulatory cells (Tregs), memory/effector CD4+ T cells, and CD8+ T cells. Th17 cells have been demonstrated to co-express CD161, as surface IL-17A+ cells are contained within the CD161+ fraction of CD4 T cells, so that CD161 (in combination with CCR6) is often used as a marker for enrichment of Th17 cells. |
| G4131 |
APC-Cy7 Anti-CD23 (B3B4) mAb |
CD23 is a 45 kDa glycoprotein that serves as a low-affinity receptor for IgE, playing a crucial role in regulating IgE responses and B cell activation. It is expressed on mature B cells, mantle zone B cells, follicular dendritic cells, and at lower levels on T cells, NK cells, Langerhans cells, and platelets. CD23 expression is upregulated upon B cell activation, and its soluble forms are biologically active, acting as potent mitogenic factors. CD23 is strongly expressed on Epstein-Barr virus (EBV)-transformed B lymphoblasts and is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells. It is also detected in neoplastic cells from cases of B cell chronic lymphocytic leukemia and some centroblastic/centrocytic lym |
| H0171 |
APC-Cy7 Anti-CD27 (O323) mAb |
CD27 (TNFRSF7) is a cell surface homodimer of ≥55 kDa subunits that provides co-stimulatory signaling in support of T cell (TCR) and B cell (BCR) receptors. Compared to CD28, whose TCR co-stimulatory signal can trigger cell proliferation, CD27 signaling promotes cell survival and differentiation to effector/memory stages. CD27 may be shed following interaction with its ligand CD70, which is typically expressed on activated dendritic cells, T cells, and B cells. In B cells, CD27 is a phenotypic marker for memory B cells and has also been included among markers for identifying B regulatory cells (Bregs), which regulate CD4+ T cell proliferation and Foxp3/CTLA-4 expression in Treg cells. |
| G1101 |
APC-Cy7 Anti-CD278 (C398.4A) mAb |
ICOS, also known as inducible costimulatory molecule and H4, is a 47-57 kD protein. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes. It is able to costimulate T cells proliferation. In addition, ICOS is involved in humoral immune responses (B cell germinal center formation). The ICOS ligand is B7h/B7RP-1 or B7-H2. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development. |
| G0201 |
APC-Cy7 Anti-CD31/PECAM-1 (390) mAb |
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulatio |
| G4101 |
APC-Cy7 Anti-CD326/EpCAM (G8.8) mAb |
Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA), also known as CD326, is a transmembrane glycoprotein expressed in the epithelium with a molecular weight of approximately 40 kDa, which functions as an epithelial cell adhesion molecule. Ep-CAM functions as a homotypic calcium-independent cell adhesion molecule, and has a direct impact on cell cycle, proliferation and metabolism of epithelial cells and fibroblasts due to its ability to rapidly induce the proto-oncogene c-myc and the cell cycle regulating genes cyclin A and E. Ep-CAM mediates Ca2+-independent homotypic interactions. Formation of Ep-CAM-mediated adhesions have a negative regulatory effect on adhesions mediated by classic cadherins, which may have strong |
| G0021 |
APC-Cy7 Anti-CD45 (30-F11) mAb |
CD45, also known as Leukocyte Common Antigen (LCA). CD45 is expressed by all hematopoietic cells excluding mature erythrocytes and platelets. The cytoplasmic portion of CD45 has tyrosine phosphatase enzymatic activity and plays an important role in activation of lymphocytes.
|
| G0351 |
APC-Cy7 Anti-CD45.1 (A20) mAb |
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides t |
| G0111 |
APC-Cy7 Anti-CD45R/B220 (RA3-6B2) mAb |
CD45R (PTPRC) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. CD45 contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. CD45 is specifically expressed in hematopoietic cells and has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists in multiple isoforms as a result of alternative splicing, and these isoforms di |
| G3486 |
APC-Cy7 Anti-CD5 (53-7.3) mAb |
CD5 is a 67 kDa human T-lymphocyte single-chain transmembrane glycoprotein. CD5 is present on all mature T-lymphocytes, on most of thymocytes and on many T-cell leukemias and lymphomas. CD5 also reacts with a subpopulation of activated B-cells and may act as a receptor in regulating T-cell proliferation. CD5 is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. CD5 is expressed by many T cell leukemia, lymphomas, and activated T cells. Diseases associated with CD5 dysfunction include thymus cancer and Richter's Syndrome. |
| G0246 |
APC-Cy7 Anti-CD62L/L-Selectin (MEL-14) mAb |
The human CD62L is a 74-95 kDa glycoprotein member of the selectin family of adhesion receptors. L-Selectin is comprised of an aminoterminal C-type lectin binding domain, an epidermal growth factor-like domain, two short consensus repeat (SCR) sequences homologous to those found in complement binding proteins, a short spacer region, a transmembrane region and a short cytoplasmic region. Human CD62L (L-Selectin) is constitutively expressed on all classes of leukocytes including lymphocytes (except a substantial population of memory T cells), monocytes and polymorphonuclear cells. |
| G0501 |
APC-Cy7 Anti-CD68 (FA-11) mAb |
CD68 is considered a pan-macrophage marker, predominantly expressed on the intracellular lysosomes of tissue macrophages/monocytes, including Kupffer cells, microglia, histiocytes and osteoclasts, and is expressed to a lesser extent by dendritic cells and peripheral blood granulocytes. CD68 is expressed by many tumor types including some B cell lymphomas, blastic NK lymphomas, melanomas, granulocytic (myeloid) sarcomas, hairy cell leukemias, and renal, urinary and pancreatic tumors, and can be used to demonstrate the presence/localization of macrophages. |
| H0771 |
APC-Cy7 Anti-FCER1A (AER-37 (CRA1)) mAb |
Fc epsilon RI alpha, also known as FcεRIα, is a subunit of the high-affinity receptor for IgE, primarily expressed on mast cells and basophils. Its expression is upregulated by the presence of IgE. FcεRIα forms a tetrameric complex with one beta and two gamma subunits, which are essential for signal transduction. The beta and gamma subunits contain immunoreceptor tyrosine-based activation motifs (ITAMs). The FcεRI complex plays a crucial role in triggering IgE-mediated allergic reactions.
When allergen-bound IgE molecules bring together two or more high-affinity IgE receptors, it leads to the release of mediators such as histamine, which are responsible for allergy symptoms.
This process couples allergens and mast cells to initiate inflamma |
| H1461 |
APC-Cy7 Anti-Human CD10 (HI10a) mAb |
CD10, also known as Neutral Endopeptidase (NEP), Enkephalinase, Atriopeptidase, and Neprilysin, is a 100 kDa type II transmembrane glycoprotein encoded by the MME (membrane metallo-endopeptidase) gene. CD10 has neutral endopeptidase activity and is also referred to as the Common Acute Lymphoblastic Leukemia Antigen (CALLA). It is expressed on a wide variety of normal and neoplastic cell types, including granulocytes, bone marrow stromal cells, a subset of B-cell progenitors, germinal center B cells, and fibroblasts. CD10 is a cell surface metalloendopeptidase that inactivates several signaling molecules, playing a significant regulatory role in the nervous, immune, and other systems. |
| H0456 |
APC-Cy7 Anti-Human CD107a (H4A3) mAb |
CD107a, also known as Lysosomal-associated membrane protein 1 (LAMP-1), is a ~110 kDa type I transmembrane protein that is heavily glycosylated and widely expressed by cells primarily on the luminal surface of their lysosomes. It is also expressed on the surface of activated platelets, activated lymphocytes, cytotoxic T cells and NK cells, and some tumor cell lines, including U937 and KG1a. LAMP-1 can serve as a ligand for E-selectin-mediated cell adhesion. LAMP-1 and LAMP-2 (CD107b) are carriers for poly-N-acetyllactosamines and are able to display sialyl Le[x] termini. |
| H0381 |
APC-Cy7 Anti-Human CD117 (104D2) mAb |
CD117 is a 145 kD protein tyrosine kinase also known as c-Kit. It is a receptor for stem cell factor or c-Kit ligand. CD117 is expressed on pluripotent hematopoietic progenitor cells (approximately 1-4% bone marrow cells), mast cells, and acute myeloid leukemia cells (AML). CD117 binding of c-Kit ligand induces phosphorylation of CD117 and stimulates proliferation and survival of primitive hematopoietic stem cells as well as erythroid-committed and granulo-monocytic committed cells. |
| H0066 |
APC-Cy7 Anti-Human CD11b (ICRF44) mAb |
CD11b is a 165-170 kD type I transmembrane glycoprotein also known as αM integrin, Mac-1, CR3, and C3biR. CD11b non-covalently associates with integrin β2 (CD18) and is expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b/CD18 is critical for the transendothelial migration of monocytes and neutrophils. It is also involved in granulocyte adhesion, phagocytosis, and neutrophil activation. CD11b/CD18 interacts with ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4, CD14, CD23, heparin, iC3b, fibrinogen, and factor X. |
| H3801 |
APC-Cy7 Anti-Human CD137 (4B4-1) mAb |
CD137 is a 39 kD transmembrane protein also known as 4-1BB. It is expressed on activated T cells. CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily. CD137 appears to be important for T cell proliferation and survival, and induces monocyte activation through its interaction with 4-1BB ligand. |
| H0186 |
APC-Cy7 Anti-Human CD14 (M5E2) mAb |
CD14 is a 53–55 kDa glycosylphosphatidylinositol (GPI)-anchored single-chain glycoprotein expressed at high levels on monocytes, macrophages, and neutrophils. CD14 is a multifunctional receptor and is constitutively expressed on the surface of mature monocytes and macrophages. It serves as a high-affinity receptor for lipopolysaccharide (LPS) and binds LPS in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute-phase serum protein. CD14 also exists in a soluble form (sCD14) and is released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. The soluble sCD14 is important for neutralizing allochthonous lipopolysaccharides by reconstituted lipoprotein particles and can discriminate structural dif |
| H1356 |
APC-Cy7 Anti-Human CD152/CTLA-4 (BNI3) mAb |
CD152, also known as CTLA-4 (Cytolytic T Lymphocyte-Associated Antigen 4), is a molecule transiently expressed on activated CD28+ T cells. It binds to CD80 and CD86 on antigen-presenting cells (APCs) with high avidity, delivering a negative regulatory signal to the T cell. It has also been shown that CTLA-4 is expressed on B cells when cultured with activated T cells, indicating a role in regulating the B-cell response. Additionally, CD152 is expressed on regulatory T (Treg) cells. The BNI3 monoclonal antibody specifically binds to human CTLA-4 and can be used to study its role in T-cell proliferation and regulation.
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| H1131 |
APC-Cy7 Anti-Human CD16 (3G8) mAb |
CD16a is a ~50–65 kDa type I transmembrane glycoprotein encoded by FCGR3A (Fc fragment of IgG receptor IIIa), which belongs to the immunoglobulin superfamily. CD16a is also known as Fc-gamma RIII-alpha (FcγRIIIA or FcRIIIa) and is expressed on natural killer (NK) cells, activated monocytes, macrophages, γδ T cells, immature thymocytes, and mast cells. CD16a binds immune-complexed or aggregated IgG and associates with CD247/TCRζ in NK cells and FcεRIγ chains in phagocytes and mast cells to transduce intracellular signals. CD16a functions in antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses including phagocytosis, cytokine production, or mediator release. CD16b is a ~48 kDa glycophosphatidylinositol (GPI)- |
| H3501 |
APC-Cy7 Anti-Human CD163 (GHI/61) mAb |
CD163 is also known as Scavenger receptor cysteine-rich type 1 protein M130 (M130), Hemoglobin scavenger receptor and Macrophage-associated antigen. CD163 is a 110-130 kDa transmembrane glycoprotein. CD163 is a monocyte/macrophage-restricted antigen expressed on the majority of tissue macrophages and peripheral blood monocytes. CD163 belongs to the scavenger receptor superfamily. Its expression on monocytes is upregulated upon cellular activation. CD163 expression reportedly changes on monocytes and macrophages as these cells differentiate. This finding suggests a role for this molecule in the differentiation and/or regulation of monocyte and macrophage function. CD163 may play a role in the clearance and endocytosis of hemoglobin and hapto |
| H0006 |
APC-Cy7 Anti-Human CD19 (HIB19) mAb |
CD19 is a 95 kDa type I transmembrane glycoprotein expressed during all stages of B-cell maturation and differentiation, except on plasma cells. It is also present on follicular dendritic cells but not found on T cells or normal granulocytes. CD19 functions as a signal transduction molecule that regulates B cell development, activation, proliferation, and differentiation. It associates with complement receptor 2 (CD21), TAPA-1 (CD81), Leu 13, and/or MHC class II to form a signal transduction complex on the surface of B cells.
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| H1026 |
APC-Cy7 Anti-Human CD195 (2D7/CCR5) mAb |
CCR5, also known as CD195, is a seven transmembrane-spanning G protein-coupled receptor (GPCR) that belongs to the beta chemokine receptor family. It is expressed on a subset of T lymphocytes (CD3⁺CD45RO⁺CD95⁺). CCR5 plays a key role in regulating lymphocyte chemotaxis, activation, and transendothelial migration during inflammation by responding to at least three chemokines: RANTES (Regulated upon Activation, Normal T-cell Expressed and Secreted), MIP-1 (Macrophage Inflammatory Protein-1), and MCP-2 (Monocyte Chemoattractant Protein 2). Additionally, CCR5 serves as a coreceptor for macrophage-tropic HIV-1 on CD4⁺ T cells, which is critical for viral entry and transmission. Individuals with partial (heterozygous) or complete (homozygous) del |
| H1581 |
APC-Cy7 Anti-Human CD1a (HI149) mAb |
CD1a is a type I transmembrane glycoprotein. The 49 kDa CD1a polypeptide is associated with β2-microglobulin. CD1a is expressed on cortical thymocytes, dendritic cells and Langerhans cells. CD1a has structural similarities to the MHC class I antigen, and plays a role in antigen presentation. |
| H1596 |
APC-Cy7 Anti-Human CD1c (L161) mAb |
CD1c, also known as R7 or M241, is a 43 kD member of the five CD1 antigens (CD1a-e) in humans. The CD1 molecules are type I glycoprotein with structural similarities to MHC class I and are non-covalently associated with β2-microglobulin, belonging to the Ig superfamily. CD1c is expressed on cortical thymocytes, Langerhans cells, dendritic cells, and a subset of B cells. It has been reported that CD1c is also expressed on mature T cells in a tightly regulated manner. CD1c is involved in antigen-presentation of glycolipids. It may also act in T cells as an immune regulatory molecule. |
| H4251 |
APC-Cy7 Anti-Human CD25 (M-A251) mAb |
The CD25 antigen is also known as the human low-affinity interleukin-2 receptor α chain (IL-2Rα) and the Tac antigen. The CD25antigen is present on a subset of peripheral blood lymphocytes. Antigen density increases on phytohemagglutinin (PHA)-, concanavalin A (Con A)-, and CD3-activated T lymphocytes; T lymphocytes from mixed lymphocyte cultures; and HTLV-infected T-lymphocyte leukemia lines, for example, HUT-102. Recombinant IL-2 blocks the binding of CD25 to PHA-activated T lymphocytes. CD4+/CD25+ regulatory T cells might directly regulate the function of responsive T cells. The CD25antibody is composed of mouse IgG1 heavy chains and kappa light chains |
| H0441 |
APC-Cy7 Anti-Human CD279/PD-1 (EH12.2H7) mAb |
Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC) are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion. |
| H1761 |
APC-Cy7 Anti-Human CD294/CRTH2 (BM16) mAb |
CD294, also known as CRTH2, is a seven-transmembrane protein coupled with heterotrimeric G proteins. CRTH2 is the prostaglandin D2 receptor and is expressed by Th2 cells, eosinophils, and basophils. CD294 prevents the apoptosis of Th2 cells and mediates the chemotaxis of CRTH2 expressing cells to the sites of allergic inflammation, such as the asthmatic lung. |
| H4281 |
APC-Cy7 Anti-Human CD3 (OKT-3) mAb |
CD3ε is one of five polypeptide chains that combine to form the TCR complex. CD3ε is expressed on T lymphocytes, NK-T cels, and to varying degrees on developing thymocytes. CD3 plays roles in TCR signaling, T lymphocyte activation, and antigen recognition. |
| H0231 |
APC-Cy7 Anti-Human CD31 (WM59) mAb |
CD31 (PECAM-1), also known as GPIIA' or EndoCAM, is a 130 kDa type I transmembrane glycoprotein belonging to the Ig gene superfamily. It is widely expressed on platelets, monocytes, granulocytes, NK cells, T cell subsets, and in high amounts on endothelial cells. CD31 functions as a vascular endothelial cell adhesion molecule, playing a critical role in the transendothelial migration of leukocytes during inflammatory responses. It is also involved in thrombosis, angiogenesis, and wound healing. The antibody against PECAM-1 binds to an epitope near extracellular domain 2 of CD31.
Clone WM59 also cross-reacts with peripheral blood platelets and leukocytes of baboon, and both rhesus and cynomolgus macaque monkeys. The staining intensity of WM5 |
| H3651 |
APC-Cy7 Anti-Human CD366 (F38-2E2) mAb |
CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells). Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance. |
| H3381 |
APC-Cy7 Anti-Human CD39 (A1) mAb |
CD39 is an integral membrane protein with two transmembrane domains in humans. It exists as a homotetramer. Expression of CD39 is found on activated lymphocytes, a subset of T cells and B cells, and dendritic cells with weak staining on monocytes and granulocytes. CD39 and CD73 have been found on regulatory T cells, specifically the effector/memory like T cells. CD39 can hydrolyze both nucleoside triphosphates and diphosphates. CD39 is the dominant ecto nucleotidase of vascular and placental trophoblastic tissues and appears to modulate the functional expression of type 2 purinergic (P2) G protein coupled receptors (GPCRs). CD39 has intrinsic ecto-ATPase activity. Expression of CD39 is induced on T cells and increased on B cells as a late a |
| H0891 |
APC-Cy7 Anti-Human CD41a (HIP8) mAb |
CD41a, also known as Integrin αIIb or Platelet GPIIb, forms a calcium-dependent complex with CD61 (β3 integrin or GPIIIa) that is normally expressed on platelets and megakaryocytes. The CD41/CD61 complex serves as a receptor for fibrinogen, fibronectin, and von Willebrand factor, mediating platelet adhesion and aggregation. Blocking CD41 can completely inhibit ADP-, epinephrine-, and collagen-induced platelet activation, and partially inhibit ristocetin- and thrombin-induced activation. |
| H0741 |
APC-Cy7 Anti-Human CD45RA (HI100) mAb |
CD45RA, a 220 kDa isoform of the human leukocyte common antigen, is expressed on approximately 40–50% of peripheral CD4+ T cells, 50% of peripheral CD8+ T cells, and on a portion of B cells and monocytes. The CD45RA antigen is expressed by naïve and activated T cells. CD45RA-specific antibodies are useful for the study of the suppressor/inducer subpopulation of CD4+ lymphocytes. |
| H4011 |
APC-Cy7 Anti-Human CD45RO (UCHL1) mAb |
CD45RO is a 180 kDa isoform of the CD45 molecule, also known as the Leukocyte Common Antigen. It is a type I transmembrane glycoprotein with cytoplasmic protein tyrosine phosphatase activity involved in signal transduction. Unlike other CD45 isoforms, CD45RO lacks the amino acid sequences encoded by the variable exons A, B, and C. It is expressed on most thymocytes, activated T cells, memory T cells, granulocytes, and monocytes, and on a subset of resting T cells. CD45RO and CD45RA mark largely distinct populations within resting peripheral T cells, demonstrating functional and phenotypic heterogeneity within CD4 and CD8 T cell subsets. CD45RO also interacts with CD22. |
| H0531 |
APC-Cy7 Anti-Human CD49f (GoH3) mAb |
CD49f, also known as the integrin α6 chain, is a ~150 kDa type I transmembrane glycoprotein that belongs to the integrin alpha chain family of extracellular matrix and cell adhesion receptors. The integrin α6 subunit associates with the integrin β1 chain (CD29) to form VLA-6, and with the integrin β4 chain (CD104) to form the integrin α6β4 complex, also known as the laminin and kalinin receptor. CD49f is expressed mainly on T cells, monocytes, platelets, epithelial cells, endothelial cells, perineural cells, and trophoblasts of the placenta. Antibodies against CD49f can block the binding of integrin α6 to laminin P1 and E8 fragments. |
| H0516 |
APC-Cy7 Anti-Human CD68 (Y1/82A) mAb |
CD68, also known as Scavenger receptor class D member 1 (SCARD1), Macrosialin, or GP110, is a 110 kDa type I transmembrane glycoprotein primarily localized in cytoplasmic granules of monocytes, macrophages, dendritic cells, granulocytes, myeloid progenitor cells, and reportedly, a subset of CD34-positive hematopoietic bone marrow progenitor cells. CD68 belongs to the sialomucin family and functions as a scavenger receptor, capable of binding and internalizing oxidized low-density lipoproteins (LDL). Antibodies targeting CD68 are commonly used in studies of myeloid cell development and function. |
| H0366 |
APC-Cy7 Anti-Human CD73 (AD2) mAb |
CD73, also known as ecto-5'-nucleotidase, is a 70 kDa, glycosyl phosphatidylinositol (GPI)-anchored glycoprotein. CD73 is expressed on subsets of T and B lymphocytes, follicular dendritic cells, epithelial cells, endothelial cells and mesenchymal stem cells. Its expression on lymphocytes increases during T and B cell development. CD73 has enzymatic activity and catalyzes the dephosphorylation of adenosine monophosphate (AMP), converting it to adenosine. It has been suggested that CD73 can mediate costimulatory signals in T cell activation and adhesion of lymphocytes to endothelium. |
| H0546 |
APC-Cy7 Anti-Human CD8 (SK1) mAb |
CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck. |
| H1476 |
APC-Cy7 Anti-Human CD83 (HB15e) mAb |
CD83 is a 45 kDa type I transmembrane glycoprotein that belongs to the immunoglobulin (Ig) superfamily. It is composed of a single V-type Ig extracellular domain and a C-terminal cytoplasmic tail. CD83 is primarily expressed on the surface of follicular dendritic cells, circulating dendritic cells, interdigitating dendritic cells in lymphoid tissues, in vitro-generated dendritic cells, and thymic dendritic cells. However, its expression is not limited to dendritic cells; it is also found on some germinal center B cells and certain lymphoblastoid cell lines. While the exact function of CD83 is not fully understood, it is believed to play a role in cell-cell interactions during antigen presentation. |
| H0306 |
APC-Cy7 Anti-Human CD90(P15F7) mAb |
CD90, also known as Thy-1, is a 25-35 kDa glycophosphatidylinositol-anchored membrane glycoprotein of the Ig superfamily. It is expressed on 1-4% of human fetal liver cells, cord blood cells, and bone marrow cells. CD90 is present on a subset of immature CD34+ cells and a distinct subset of mature CD34- cells that are CD3+CD4+. The CD90+CD34+ population is highly enriched for cells capable of long-term culture. The anti-CD90 antibody is useful for enriching high proliferative potential colony-forming cells (HIPP-CFC), which are primitive progenitor cells. |
| H1791 |
APC-Cy7 Anti-Human HLA-A2 (BB7.2) mAb |
HLA-A2 is a class I molecule of the major histocompatibility complex (MHC) and part of the highly polymorphic group of cell-surface proteins encoded by the MHC gene locus. It plays a crucial role in the immune response by binding and presenting small antigenic protein fragments to antigen-specific receptors on T cells (TCR). Class I MHC molecules, like HLA-A2, bind peptides derived from intracellular antigens, such as viral and some bacterial antigens, which are recognized by CD8+ T cells. The TCRs recognize these processed peptides bound to the MHC, as well as regions of the MHC molecule itself, while CD4 and CD8 accessory molecules enhance the interaction by binding non-polymorphic regions of the MHC. |
| H3696 |
APC-Cy7 Anti-Human IgD (IA6-2) mAb |
IgD is a member of the immunoglobulin superfamily that exists in type 1-membrane (mIgD) and soluble glycoprotein forms. mIgD is expressed on mature naïve B cells (along with membrane IgM) and serves as a B-cell receptor for antigen (BCR). In response to antigen binding, the mIgD BCR, in association with other signaling molecules including CD79a and CD79b, can transduce activating or tolerizing signals intracellularly into B lymphocytes. |
| H1011 |
APC-Cy7 Anti-Human IgM (MHM-88) mAb |
IgM is the first immunoglobulin made by B cells in the immune response. Surface IgM is expressed on immature and mature B cells, while IgM heavy (μ) chain is expressed intracellularly in pre-B cells. |
| H1221 |
APC-Cy7 Anti-Human IL-2 (MQ1-17H12) mAb |
Interleukin-2 (IL-2) is a key cytokine involved in immune response and tolerance. It is produced by activated T cells and plays a crucial role in the activation, growth, proliferation, and differentiation of various immune cells, including T and B lymphocytes, LAK cells, NK cells, and monocytes/macrophages. IL-2 exerts its effects through binding to IL-2 receptor complexes, which include the intermediate-affinity IL-2R (comprising IL-2Rβ and γc) and the high-affinity IL-2R (which also includes IL-2Rα, along with IL-2Rβ and γc). IL-2 is essential for the proper functioning of the immune system, particularly in promoting T cell expansion and immune responses. |
| H1851 |
APC-Cy7 Anti-Human TCR Vα7.2 (3C10) mAb |
The antibody recognizes the Vα7.2 T cell antigen receptor (TCR) α-chain segment which, joined with the Jα33 segment, constitutes an invariant TCR that is a characteristic of the mucosalassociated invariant T cells (MAIT cells). MAIT cells are restricted by a nonpolymorphic class Ib major histocompatibility complex (MHC) molecule, MHC-related molecule 1 (MR1). MAIT cells are present in human blood (1-8% of T cells), mesenteric lymph nodes, liver, and intestinal mucosa. MAIT cells play a role in detecting and fighting off microbial infections |
| H0126 |
APC-Cy7 Anti-IFN-lambda (4S.B3) mAb |
IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor and immune interferon that is produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemagglutinin, and other cytokines. IFN gamma is a dimeric protein consisting of two 146 amino acid subunits. IFN gamma is a glycoprotein that exists functionally as a homodimer of approximately 45 kDa. On SDS-PAGE, IFN gamma appears as a combination of 25, 20, and minor 15.5 kDa bands as a result of differential glycosylation. The biological activity of the IFN gamma homodimer is highly species specific. Human IFN gamma does not show cross-reactivity with mouse. IFN gamma exhibits functions such as a |
| G0366 |
APC-Cy7 Anti-Ly-6A/E/Sca-1 (D7) mAb |
Stem Cell Antigen-1 (Sca-1) is a member of the lymphocyte antigen 6 (Ly-6) family. It is expressed on multipotent hematopoietic stem cells (HSC) and is used as a marker of HSC in mice. Sca-1 is used in combination with lineage depletion antibodies to identify murine HSC. Sca-1 can be found in fetal liver, adult bone marrow, and adult peripheral blood and spleen. Sca-1 may be involved in the regulation of B and T cell activation. |
| G0441 |
APC-Cy7 Anti-Mouse CD107a (1D4B) mAb |
CD107a, also known as Lysosome-Associated Membrane Protein 1 (LAMP-1), is a type I transmembrane glycoprotein that serves as a key marker of lysosomes. It is composed of a 40 kDa core protein that is heavily glycosylated, resulting in a mature glycoprotein ranging from 110 to 140 kDa. CD107a is predominantly expressed in epithelial cells and macrophages across various organs. Upon cellular activation, it translocates to the cell surface of lymphocytes, macrophages, epithelial cells, endothelial cells, platelets, and tumor cells. Surface expression of CD107a is involved in intercellular and extracellular matrix adhesion and is widely used as a functional marker of cytotoxic activity in NK cells and CD8+ T cells, as well as in identifying som |
| G4116 |
APC-Cy7 Anti-Mouse CD138 (281-2) mAb |
CD138 (Syndecan-1) is a transmembrane proteoglycan containing both heparan sulfate and chondroitin sulfate chains. It binds to components of the extracellular matrix and plays a critical role in cell adhesion, proliferation, and signaling. CD138 is predominantly expressed on epithelial cells, where its presence is associated with normal epithelial architecture. It is also expressed on B lymphocytes during specific stages of differentiation, including precursor B cells in the bone marrow and antibody-secreting plasma cells, but is absent on mature peripheral B cells. This expression pattern implicates CD138 in B cell–matrix interactions. Its expression is regulated during embryonic development and is subject to tissue-specific structural pol |
| G4236 |
APC-Cy7 Anti-Mouse CD16/CD32 (2.4G2) mAb |
CD16 and CD32 are expressed on B cells, monocytes/macrophages, NK cells, granulocytes, mast cells, and dendritic cells. These receptors bind to the Fc portion of antibody-antigen complexes and play a role in adaptive immune responses. |
| G4386 |
APC-Cy7 Anti-Mouse CD19 (1D3) mAb |
CD19, a B lymphocyte-lineage differentiation antigen and a 95-kDa transmembrane glycoprotein, is a member of the immunoglobulin superfamily and is expressed throughout B-lymphocyte development from the pro-B cell stage through mature B cells. Terminally differentiated plasma cells do not express CD19. On mature B cells, CD19 associates with CD21 (CR-2) and CD81 (TAPA-1), forming a multimolecular complex that synergizes with surface immunoglobulin to promote cellular activation. Studies in CD19-deficient mice suggest that the level of CD19 expression influences the generation and maturation of B cells in both bone marrow and peripheral tissues. B-1 lineage B cells, also called CD5+ B cells, are drastically reduced or absent in CD19-deficient |
| G0846 |
APC-Cy7 Anti-Mouse CD38 (90) mAb |
CD38 is a 45 kD type II transmembrane glycoprotein also known as T10. It is an ADP-ribosyl hydrolase expressed at variable levels on hematopoietic cells and in some non-hematopoietic tissues (such as brain, muscle, and kidney). In humans, it is expressed at high levels on plasma cells and activated T and B cells, natural killer (NK) lymphocytes, myeloblasts, and erythroblasts. By functioning as both a cyclase and a hydrolase, CD38 mediates lymphocyte activation, adhesion, and the metabolism of cADPR and NAADP. CD31 is the ligand of CD38. |
| G4146 |
APC-Cy7 Anti-Mouse CD4 (GK1.5) mAb |
The CD4 antigen is a 55 kDa cell surface type I membrane glycoprotein belonging to the immunoglobulin superfamily. CD4 acts as a co-receptor which, in cooperation with the T cell receptor (TCR), interacts with class II MHC molecules displayed by antigen-presenting cells (APC). CD4 is expressed by the majority of thymocytes, most helper T cells, a subset of NK-T cells, and weakly by dendritic cells and macrophages. CD4 plays an important role in the development of T cells and is required for mature T cells to function optimally. |
| G0861 |
APC-Cy7 Anti-Mouse CD41 (MWReg30) mAb |
CD41 is a transmembrane glycoprotein that is encoded by Itga2b. CD41 associates with Integrin β3 chain (gpIIIa or CD61) to form the gpIIb/IIIa (CD41/CD61) complex. CD41/CD61 is expressed on platelets, megakaryocytes, and early hematopoietic progenitors. The integrin complex binds to fibrinogen, fibronectin, vitronectin, von Willebrand factor, and thrombospondin. It is important for platelet adhesion and aggregation, and it may play a role in osteolytic tumor metastasis. |
| G4416 |
APC-Cy7 Anti-Mouse CD86 (GL1) mAb |
CD86, along with CD80, is a member of the B7 family of costimulatory molecules and plays a crucial role in T cell activation and immune response regulation. CD86 is expressed at low levels on B cells, macrophages, and dendritic cells, and its expression is upregulated on B cells through various stimuli, including the BCR complex, CD40, and certain cytokine receptors. As a type I membrane protein and member of the immunoglobulin superfamily, CD86 serves as a ligand for the T cell surface proteins CD28 and CTLA-4 (CD152). The interaction between CD86 and CD28 provides a costimulatory signal essential for T cell activation during antigen presentation, while binding with CTLA-4 negatively regulates T cell activation, diminishing the immune resp |
| G0786 |
APC-Cy7 Anti-Mouse IL-10 (JES5-16E3) mAb |
IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. D |
| G4431 |
APC-Cy7 Anti-Mouse Ly6G (1A8) mAb |
Lymphocyte antigen 6 complex, locus G (Ly-6G), is a 21–25 kDa GPI-anchored protein expressed primarily on peripheral granulocytes and highly specific for neutrophils. Ly-6G serves as a robust marker for neutrophil identification and depletion in mice. Ly-6G modulates neutrophil migration and recruitment to sites of inflammation via interaction with β2 integrins. Its downregulation is associated with age-related functional decline in neutrophils. |
| G4251 |
APC-Cy7 Anti-Mouse NK1.1 (PK136) mAb |
NK1.1, also known as CD161b/CD161c, KLRB1, NKR-P1A, and Ly-55, is a type II integral membrane glycoprotein with a C-type lectin domain and is encoded by the Klrb1c/NKR-P1C gene. NK1.1 plays roles in NK cell activation and differentiation, IFN-γ production, cytotoxic granule release, and is thought to be involved in the generation of Th2 cells. NK1.1 is predominantly expressed as a disulfide-linked homodimer on NK cells; however, it is also expressed on NK-T cells, a rare population of T lymphocytes. NK1.1 is only expressed by C57BL/6, FVB/N, and NZB strains of mice and not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129 strains. |
| G1671 |
APC-Cy7 Anti-Mouse TCR Vα2 (B20.1) mAb |
TCR Vα2 is a distinct T-cell receptor (TCR) subfamily found in mice with the a, b, and c haplotypes. The TCR α chain complexes with the TCR β chain in 95% of T cells, forming the T cell receptor (α/β TCR), while the remaining 5% of T cells express gamma (γ) and delta (δ) chains (γ/δ TCR). TCR Vα2 represents a specific variant of the TCR α chain that plays a role in antigen recognition and is useful in the study of T-cell function and immune responses in mice with these specific haplotypes. |
| G1296 |
APC-Cy7 Anti-Podoplanin(L7B2) mAb |
Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin type-1 glycoprotein with a 40-43 kDa molecular weight. Podoplanin is expressed in many tumors and normal cells, especially lymphatic epithelial cells and follicular DCs. Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. Podoplanin appears to serve as a ligand for CLEC-2 and expression is positively correlated with tumors expressing greater invasive and metastatic potential. Podoplanin is directly involved in cell migration, aids metastases formation and tumor cell invasion of tissue. Further, it has also been determined that |
| G4191 |
APC-cy7 Mouse IgG1 isotype control (MOPC-21) |
Mouse IgG1 isotype control is a mouse myeloma protein. It was selected as an isotype control following screening for low background on a variety of mouse and human tissues. |
| F0932 |
APC8 Rabbit mAb |
|
| S9605 |
Apcin |
Apcin (APC inhibitor) is an inhibitor of the E3 ligase activity of the mitotic anaphase-promoting complex/cyclosome (APC/C) that binds to Cdc20 and competitively inhibits the ubiquitylation of D-box-containing substrates. |
| S0110 |
APD597 |
APD-597 (JNJ-38431055) is a potent and selective G protein-coupled receptor 119 (GPR119) agonist with EC50 of 46 nM for hGPR119 and an inhibitor of Cytochrome P450 2C9 (CYP2C9) with IC50 of 5.8 μM. APD-597 (JNJ-38431055) is developed for treating Type 2 diabetes (T2D). |
| S6746 |
APD668 |
APD668 (JNJ28630368) is a potent GPR119 agonist with EC50s of 2.7 and 33 nM for human and rat forms, respectively. |
| F1522 |
APE Mouse mAb |
APE,APE1,Ref-1 |
| A5410 |
APE1 Rabbit Recombinant mAb |
APE1 Rabbit Recombinant mAb detects endogenous level of total APE1. |
| P1211 |
Apelin-13 |
Apelin-13 can efficiently activate the APJ receptor with EC50 of 0.37 nM and result in suppress the forskolin-stimulated cAMP production.
|
| E1508 |
APG-2449 |
APG-2449 is an orally active inhibitor of ALK/ROS1/FAK. APG-2449 exerts potent and durable antitumor activity in human non-small-cell lung cancer (NSCLC) and ovarian tumor models. |
| S9970 |
APG-2575 (lisaftoclax) |
APG-2575 (lisaftoclax) is a dual Bcl-2 and Bcl-xl inhibitor with IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively. |
| A5711 |
Apg10 (Atg10) Rabbit Recombinant mAb |
Apg10 (Atg10) Rabbit Recombinant mAb detects endogenous level of total Apg10 (Atg10). |
| A5219 |
Apg12 Rabbit Recombinant mAb |
Apg12 Rabbit Recombinant mAb detects endogenous level of total Apg12. |
| A5565 |
Apg12(Atg12) Rabbit Recombinant mAb |
Apg12(Atg12) Rabbit Recombinant mAb detects endogenous level of total Apg12(Atg12). |
| A5304 |
Apg3 (Atg3) Rabbit Recombinant mAb |
Apg3 (Atg3) Rabbit Recombinant mAb detects endogenous level of total Apg3 (Atg3). |
| S2262 |
Apigenin |
Apigenin is a potent P450 inhibitor for CYP2C9 with Ki of 2 μM. |
| E0130 |
Apigenin-7-O-glucuronide |
Apigenin-7-O-glucuronide (Apigenin-7-glucuronide) is the major flavonoid found in milk thistle. Apigenin 7-o-glucuronide inhibits tumor necrosis factor alpha (TNF-α) and total nitrite release in lipopolysaccharide-activated macrophages.
|
| S9125 |
Apigetrin |
Apigetrin (Cosmetin, Cosmosioside, Thalictiin, Cosmosin, Apigenin 7-glucoside), a flavonoid found in many plant leaves and seeds, has been known to possess antimutagenic, anti-cancer, antioxidant and anti-inflammatory properties. |
| S6414 |
Apilimod |
Apilimod is a potent and orally-available inhibitor of the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23) with the potential to treat certain autoimmune and inflammatory diseases. Apilimod (STA-5326) inhibits IL-12 with IC50 of 1 nM, 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs, human monocytes and mouse PBMCs, respectively. Apilimod (STA-5326) is also a cell permeable small molecule that specifically inhibits PIKfyve with IC50 of 14 nM. |
| S0785 |
Apilimod mesylate |
Apilimod mesylate is a potent and orally-available inhibitor of the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23) with the potential to treat certain autoimmune and inflammatory diseases. Apilimod mesylate (STA-5326 mesylate) inhibits IL-12 with IC50 of 1 nM, 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs, human monocytes and mouse PBMCs, respectively. Apilimod mesylate (STA-5326 mesylate) is also a cell permeable small molecule that specifically inhibits PIKfyve with IC50 of 14 nM. |
| S2696 |
Apitolisib (GDC-0980) |
Apitolisib (GDC-0980, RG7422, GNE 390) is a potent, class I PI3K inhibitor for PI3Kα/β/δ/γ with IC50 of 5 nM/27 nM/7 nM/14 nM in cell-free assays, respectively. Also a mTOR inhibitor with Ki of 17 nM in a cell-free assay, and highly selective versus other PIKK family kinases. Apitolisib activates autophagy and apoptosis simultaneously in pancreatic cancer cells. Phase 2. |
| S1593 |
Apixaban |
Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively. |
| S5846 |
Apocarotenal |
Apocarotenal is a carotenoid found in spinach and citrus fruits and plays a role as a precursor of vitamin A. |
| S2425 |
Apocynin |
Apocynin is a selective NADPH-oxidase inhibitor with IC50 of 10 μM. |
| E3437 |
Apocynum venetum Extract |
Apocynum Venetum Extract is extracted from Apocynum Venetum, which helps to improve the quality of sleep. |
| F2042 |
ApoER2 Rabbit mAb |
|
| A5642 |
Apolipoprotein E Rabbit Recombinant mAb |
Apolipoprotein E Rabbit Recombinant mAb detects endogenous level of total Apolipoprotein E. |
| L3300 |
Apoptosis Compound Library |
A unique collection of 1222 small molecules used for apoptosis research targeting Bcl-2,Caspase,p53,TNF-alpha,Mdm2,survivin, etc.
|
| S8365 |
Apoptozole |
Apoptozole (Apoptosis Activator VII) is an inhibitor of heat shock protein 70(HSP70) and Hsc70 with dissociation constants Kd of 0.14 μM and 0.21 μM, respectively. It induces caspase-dependent apoptosis. |
| S9705 |
Apostatin-1 (Apt-1) |
Apostatin-1 (Apt-1) is a novel TRADD inhibitor. Apostatin-1 binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N). Apostatin-1 inhibits bortezomib-induced apoptosis and RIPK1-dependent apoptosis (RDA) with an IC50 of about 1 μM. |
| F0030 |
APP A4 Mouse mAb |
Amyloid Precursor Protein,Amyloid Precursor Protein, C-Terminal,APP,APP A4,APP/β-Amyloid |
| F0618 |
APPL1 Rabbit mAb |
APPL,APPL1 |
| E3537 |
Apple cider vinegar Extract |
Apple Cider Vinegar Extract is extracted from apple cider vinegar, which has antimicrobial activity. |
| E3538 |
Apple Extract |
Apple Extract is extracted from Malus, which has an anti-cariogenic effect on S. mutans and aids in the prevention of dental caries. |
| S6583 |
Apraclonidine HCl |
Apraclonidine (Iopidine,ALO 2145) is a sympathomimetic used in glaucoma therapy. It is an alpha2-adrenergic agonist. |
| E0021 |
Apraglutide (FE 203799) |
Apraglutide (FE 203799) is a potent and highly selective GLP-2 agonist with EC50s of 0.03 nM and 0.07 nM for hGLP-2 Receptor and rGLP-2 Receptor, respectively.
|
| S4254 |
Apramycin Sulfate |
Apramycin Sulfate (Ai3-29795) is an aminoglycoside antibiotic, which binds to the deep groove of the RNA. |
| S8034 |
Apremilast |
Apremilast (CC-10004) is a potent and orally active PDE4 and TNF-α inhibitor with IC50 of 74 nM and 77 nM, respectively. |
| S1189 |
Aprepitant |
Aprepitant is a potent and selective neurokinin-1 receptor antagonist with IC50 of 0.1 nM. Aprepitant reduces levels of pro-inflammatory cytokines including G-CSF, IL-6, IL-8 and TNFα. Aprepitant inhibits HIV infection of human macrophages. |
| E4771 |
Aprocitentan |
Aprocitentan (ACT-132577) is a pharmacologically active metabolite of Macitentan. Aprocitentan is an orally active dual antagonist of ETA/ETB with IC50 values of 3.4 nM and 987 nM, and pA2 values of 6.7 and 5.5, respectively. |
| S6450 |
Apronal |
Apronal (Apronalide, Allylisopropylacetylurea, Allylisopropylacetylcarbamide) is a hypnotic/sedative drug. |
| S7377 |
Aprotinin |
Aprotinin is a small protein serine protease inhibitor (Kd=0.06 pM for bovine β-trypsin), used to reduce perioperative blood loss and transfusion.
|
| A2498 |
Aprutumab (Anti-FGFR2 / CD332) |
Aprutumab (Anti-FGFR2 / CD332) is a fully human FGFR2 monoclonal antibody, which binds to the FGFR2 isoforms FGFR2-IIIb and FGFR2-IIIc. Aprutumab has the potential for solid tumors research. MW: 78.2 KD. |
| S3493 |
APS6-45 |
APS6-45(Compound 10) is an orally active tumor-calibrated inhibitor (TCI) that inhibits RAS/MAPK signaling and exhibits antitumor activity. |
| S6963 |
APTO-253 |
APTO-253 (LOR-253, LT-253) inhibits c-Myc expression and selectively induces CDKN1A (p21), promotes G0-G1 cell-cycle arrest, and triggers apoptosis in acute myeloid leukemia (AML) cells. APTO-253 is also an inducer of KLF4 (Krüppel-like factor 4).
|
| A4057 |
Apv-527 (Anti-4-1BB & 5T4) |
APV-527 is a bispecific antibody targeting 4-1BB on T-cells and the 5T4 tumor antigen to stimulate immune responses against solid tumors. It is being developed for advanced solid tumors, including non-small cell lung cancer, breast cancer, and pancreatic cancer, with positive safety and efficay. M.W 157.94 kDa |
| S7445 |
APX-3330 |
APX-3330 (E3330) is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.
|
| E1987 |
APX2009 |
APX2009 is a second-generation redox-specific inhibitor of APE1/Ref-1, an essential enzyme in the base excision repair (BER) pathway. APX2009 effectively reduces breast cancer cell proliferation and colony formation. |
| S6623 |
APY29 |
APY29 is a type I kinase inhibitor of IRE1α that binds to the ATP-binding site on IRE1α and inhibits its autophosphorylation (IC50 = 280 nM) and enhances its RNase function (EC50 = 460 nM). |
| E7060 |
AQC |
AQC is a reagent used for amino acid or protein sequence analysis by HPLC with fluorescence detection (λ_ex 250 nm, λ_em 395 nm). It reacts with primary and secondary amino acids to yield stable fluorescent derivatives, enabling detection at under-picomolar levels. |
| F1586 |
Aquaporin 1 Rabbit mAb |
Aquaporin 1,Aquaporin 1/AQP1 |
| E3090 |
Aquilariae Lignum Resinatum Extract |
Aquilariae Lignum Resinatum Extract is obtained from the dry rhizome of Aquilariae Lignum Resinatum (Thymelaeaeeae), has been widely used to treat emesis, stomachache and gastrointestinal dysfunction. |
| S3486 |
AQX-016A |
AQX-016A is a potent agonist of SHIP1. AQX-016A inhibits DNFB induced inflammation in a mouse ear edema/cutaneous anaphylaxis model. |
| S2244 |
AR-42 |
AR-42 (HDAC-42) is an HDAC inhibitor with IC50 of 30 nM. Phase 1. |
| S7435 |
AR-A014418 |
AR-A014418 (GSK-3β Inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor with IC50 and Ki of 104 nM and 38 nM in cell-free assays, without significant inhibition on 26 other kinases tested. |
| S7919 |
AR-C155858 |
AR-C155858 is a selective monocarboxylate transporter MCT1 and MCT2 inhibitor with Ki value of 2.3 nM and 10 nM, respectively. |
| S6605 |
AR7 |
AR7 is a retinoic acid receptor α (RARα) antagonist. |
| S5580 |
Arabic gum |
Arabic gum, derived from exudates of Acacia senegal or Acacia seyal trees, is a complex polysaccharide indigestible to both humans and animals and considered as a safe dietary fiber. |
| E4114 |
Arabinose |
Arabinose((±)-Arabinose; DL-Arabinose; dl-Arabinose) is an endogenous metabolite. It is a natural sugar molecule that exhibits sweetness profiles similar to sucrose, making it a valuable alternative in low-calorie foods and excipients or cocrystallization agents in pharmaceutical formulations. |
| S5570 |
Arachidic acid |
Arachidic acid (eicosanoic acid, Icosanoic Acid) is a natural saturated fatty acid used for the production of detergents, photographic materials and lubricants. |
| S6185 |
Arachidonic acid |
Arachidonic acid (Arachidonate) is an unsaturated, essential fatty acid found in animal and human fat as well as in the liver, brain, and glandular organs. It is a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes., |
| E1527 |
Aramchol |
Aramchol (C20-FABAC, Icomidocholic acid) is a fatty acid-bile acid conjugate that reduces liver fat content and is a inhibitor of stearoyl CoA desaturase 1 (SCD1) and a cholesterol solubilizer. It can be used in research on fatty liver disease, blocking fibrosis by targeting hepatic stellate cells in liver injury, non-alcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD). |
| S2120 |
Arbidol HCl |
Arbidol HCl (Umifenovir) is a broad-spectrum antiviral compound that blocks viral fusion, used in treatment of influenza and other respiratory viral infections. |
| S2263 |
Arbutin |
Arbutin (Uva, p-Arbutin, β-Arbutin) is a tyrosinase inhibitor with IC50 of 0.9 mM and 0.7 mM for Monophenolase and Diphenolase, respectively. |
| F3281 |
Arc Mouse mAb |
Arc,Arg3.1 |
| S4738 |
Arctiin |
Arctiin (Arctigenin-4-Glucoside, NSC 315527) acts on an agonists of the adiponectin receptor 1 with anti-cancer effects. |
| E3782 |
Arctostaphylos Uva Ursi Leaf Extract |
Arctostaphylos Uva Ursi Leaf Extract is drawed from the Arctostaphylos uva-ursi leaf, which could represent a natural product to counter the virulence of Cutibacterium acnes, representing a new alternative therapeutic option for the treatment of acne vulgaris. |
| E3894 |
Ardisia Japonica Extract |
Ardisia Japonica Extract is extracted from Ardisia japonica, which is used in the treatment of coughs and to stop uterine bleeding. |
| E3122 |
Arecae Pericarpium Extract |
Arecae Pericarpium Extract is extracted from Arecae Pericarpium, which can be used in the treatment of gastroesophageal reflux disease. |
| E0599 |
Arecaidine hydrochloride |
Arecaidine hydrochloride, a constituent of the nut of Areca catechu, inhibits the uptake of GABA and beta-alanine, but not that of glycine. |
| S2614 |
Arecoline HBr |
Arecoline(NSC-31750) is a muscarinic acetylcholine receptor agonist. |
| S0943 |
Arenobufagin |
Arenobufagin is a natural bufadienolide from toad venom and induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway. |
| F3326 |
ARF1 + ARF3 Rabbit mAb |
|
| F1371 |
Arf6 Rabbit mAb |
|
| S5217 |
Arformoterol Tartrate |
Arformoterol Tartrate is the tartrate salt of arformoterol, a long-acting beta-2 adrenergic agonist with bronchodilator activity. |
| E7092 |
Arg-Gly-Asp-Ser |
Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1. |
| S2069 |
Argatroban (MCI-9038) |
Argatroban (MCI-9038) is a potent and selective synthetic thrombin inhibitor with Ki ranging from 5 nM to 39 nM, used as an anticoagulant. |
| S5074 |
Argatroban Monohydrate |
Argatroban (Argatroban hydrate, Argipidine,MCI-9038 Monohydrate) is a direct, selective thrombin inhibitor with anticoagulant effects. |
| F3269 |
Arginase 1 Mouse mAb |
ARG1/Arignase 1,Arginase 1,Arginase 1/ARG1/liver Arginase,Arginase I,Arginase-1,Liver Arginase |
| E1337 |
Arginase inhibitor 1 |
Arginase inhibitor 1 is a potent inhibitor of human arginases I and II with IC50s of 223 and 509 nM, respectively. |
| F0421 |
Arginase-1 Rabbit mAb |
ARG1/Arignase 1,Arginase 1,Arginase 1/ARG1/liver Arginase,Arginase I,Arginase-1,Liver Arginase |
| P1020 |
Argipressin acetate |
Argpressin Acetate is a neurohypophysial hormone found in most mammals. It acts as a neurotransmitter at synapses in the brain, increases [Ca2+]i in cultured rat hippocampal neurons. |
| S5946 |
Argireline |
Argireline is an innovative neuropeptide widely applied topically on the skin. |
| F0622 |
Argonaute 1 Rabbit mAb |
|
| F1322 |
Argonaute 3 Rabbit mAb |
|
| F0519 |
Argonaute-2 Rabbit mAb |
AGO2,Ago2/eIF2C2,Argonaute 2,Argonaute-2,EIF2C2,RIPAb+ Ago2 - RIP Validated |
| S1975 |
Aripiprazole |
Aripiprazole (OPC-14597) is a novel atypical antipsychotic drug that is reported to be a high-affinity 5-HT receptor partial agonist. |
| S5707 |
Aripiprazole lauroxil |
Aripiprazole lauroxil(Aristada) is an extended-release prodrug of aripiprazole designed for intramuscular injection. It acts as a dopamine-serotonin system stabilizer, with a potent partial agonist for dopamine D2 and serotonin 5-HT1A receptors while an antagonist for serotonin 5-HT2A receptors. |
| S9193 |
Aristolochic acid A |
Aristolochic acid A (Aristolochic Acid I, Aristolochin, Aristolochine, TR 1736) is a carcinogenic, mutagenic, and nephrotoxic agent extracted from the flowering plant family Aristolochiaceae.Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and nuclear factor-κB (NF-κB) activities. |
| S9283 |
Aristolone |
Aristolone, which could be extracted from essential oil of Elyonurus hensii, is likely to induce an antalgic activity. |
| F2408 |
ARL 13B Mouse mAb |
|
| A2150 |
Armenian hamster IgG isotype control-InVivo |
Armenian hamster IgG isotype control-InVivo is ideal for use as an isotype control for Armenian hamster IgG antibodies in most in vivo and in vitro applications. |
| E0454 |
ARN-19702 |
ARN19702 is an orally active, reversible N-Acylethanolamine acid amidase(NAAA) inhibitor (IC50 on human NAAA = 230 nM) that produces remarkable protective effects against multiple sclerosis in mice. |
| S8543 |
ARN-3236 |
ARN-3236 is a potent, orally available and selective inhibitor of salt-inducible kinase 2 (SIK2) with IC50 of <1 nM, 21.63 nM and 6.63 nM for SIK2, SIK1 and SIK3, respectively. ARN-3236 induces apoptosis in cancer cells. |
| E3614 |
Arnica montana Extract |
Arnica Montana Extract is extracted from the flowers of Arnica montana L. (Asteraceae). Arnica montana possesses anti-inflammatory, immune-modulatory, anti-sclerotic, analgesic, antifungal, antioxidant, antibacterial, and anticancer bioactivities. |
| A5282 |
Aromatase Rabbit Recombinant mAb |
Aromatase Rabbit Recombinant mAb detects endogenous level of total Aromatase. |
| S9909 |
ARP 100 |
ARP 100 (MMP-2 Inhibitor III, Compound 10a) is a potent and selective inhibitor of MMP-2 with an IC50 of 12 nM and displays less inhibitory activity at MMP-9, MMP-3, MMP-1 and MMP-7 with IC50s of 200 nM, 4500 nM, >50,000 nM and >50,000 nM respectively. |
| F2365 |
Arp3 C-terminal Rabbit mAb |
|
| F2612 |
ARPC2 Rabbit mAb |
ARPC2,p34-Arc/ARPC2 |
| S7355 |
ARQ 621 |
ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.
|
| E3799 |
Arrhenatherum Elatius Extract |
Arrhenatherum Elatius Extract is extracted from Arrhenatherum elatius (L.) Pressl.. Arrhenatherum elatius has ability to remove heavy metals from soil. |
| S3570 |
ARRY-382 |
ARRY-382 is a highly selective, oral inhibitor of the CSF1R with an IC50 of 9 nM. |
| E1856 |
ARS-1323 |
ARS-1323 is the racemic mixture, containing ARS-1620, and a potent inhibitor of mutant KRAS G12C. It can be used in research for biochemical binding screens as companion imaging drugs (CID) for KRAS G12C. |
| S8707 |
ARS-1620 |
ARS-1620 is a potent, orally bioavailable covalent inhibitor of KRASG12C and could achieve rapid and sustained in vivo target occupancy to induce tumor regression. |
| S8156 |
ARS-853 |
ARS-853 is a selective, covalent KRAS(G12C) inhibitor that inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein and preventing activation. ARS-853 also induces apoptosis. |
| E1989 |
ART0380 |
ART0380 (IACS-030380) is a potent and selective, orally bioavailable inhibitor of ATR kinase, with an IC50 of 51.7 nM effectively inhibiting the enzyme activity of the ATR-ATRIP complex. It functions as an ATP-competitive inhibitor, binding to the ATP pocket of ATR, where ATP would typically bind. It interacts with the hinge through its morpholine oxygen and occupies the ribose pocket with a sulfoximine group. It also exhibits antitumor activity. |
| E4780 |
ART26.12 |
ART26.12 is an inhibitor of fatty acid-binding protein 5 (FABP5) that selectively binds to FABP5 over FABP3, FABP4, and FABP7, exhibiting antinociceptive properties. It alleviates oxaliplatin-induced pain through lipid modulation and cannabinoid receptor activation, with potential for preventing and treating oxaliplatin-induced peripheral neuropathy (OIPN). |
| S9936 |
ART558 |
ART558 is a potent, selective, low molecular weight, allosteric inhibitor of DNA Polθ with an IC50 of 7.9 nM. |
| E1529 |
ART812 |
ART812 is an orally active DNA polymerase Polθ inhibitor with an IC50 value of 7.6 nM. |
| E1939 |
ART899 |
ART899, a derivative of ART558 is a potent, specific allosteric inhibitor of DNA polymerase theta (Polθ), specifically inhibits Polθ MMEJ activity with IC50 of 180 nM. It specifically radiosensitizes tumor cells and have a potent stand-alone antitumor effect in cancer cells. |
| S3889 |
Arteether |
Arteether is a well-known antimalarial drug which acts by producing free radicals within the malarial parasite. |
| S2264 |
Artemether |
Artemether (SM-224, CGP 56696) is an antimalarial for the treatment of resistant strains of falciparum malaria. |
| E3570 |
Artemisia annua Extract |
Artemisia Annua Extract is extracted from Artemisia Annua, which has antimalarial and anticancer effects. |
| S9135 |
Artemisic acid |
Artemisic acid (Artemisinic acid), an amorphane sesquiterpene isolated from Artemisia annua L., has a variety of pharmacological activity, such as antimalarial activity, anti-tumor activity, antipyretic effect, antibacterial activity, allelopathy effect and anti-adipogenesis effect. |
| S1282 |
Artemisinin |
Artemisinin is a sesquiterpene endoperoxide which is a potent antimalarial agent. |
| E3003 |
Artemisis Princeps Leaf Extract |
Artemisis Princeps Leaf Extract is extracted from Artemisia princeps Panpanini, contains some low-molecular-weight component which stimulates the proliferation of vascular endothelial cells in vitro, and is effective for promoting the restration of injured endothelium. |
| E1366 |
Artemisitene |
Artemisitene, a natural derivative of Artemisinin, is a Nrf2 activator with antioxidant and anticancer activities. Artemisitene activates Nrf2 by decreasing Nrf2 ubiquitination and increasing its stability. |
| E0250 |
Artemitin |
Artemitin, a significant flavonol compound existing in Laggera pterodonta (DC.) Benth., Artemisia rupestris L, etc., possesses bioactivities of antioxidative, anti-inflammatory and antiviral. |
| S2265 |
Artesunate |
Artesunate is a part of the artemisinin group of agents with an IC50 of < 5 μM for small cell lung carcinoma cell line H69. It is a potential inhibitor of STAT-3 and exhibits selective cytotoxicity of cancer cells over normal cells in vitro; A potent inhibitor of EXP1. |
| S3150 |
Articaine HCl |
Articaine (Ultracaine) is a dental local anesthetic which contains an additional ester group that is metabolized by estearases in blood and tissue. |
| E3087 |
Artichoke Extract |
Artichoke Extract is extracted from Cynara cardunculus var. scolymus, which has antioxidant, choleretic, hepatoprotective, bile-enhancing, and lipid-lowering effects. |
| E1573 |
ARV-766 |
Luxdegalutamide (ARV-766) is an orally active and potent degrader of proteolysis targeting chimera (PROTAC) protein. ARV-766 degrades wild-type androgen receptor (AR) but also relevant AR LBD mutants, including the most prevalent AR L702H, H875Y, and T878A mutations. |
| S8532 |
ARV-771 |
ARV-771 is a potent pan-(bromodomain and extra-terminal)BET degrader, a novel BET-PROTAC(proteolysis-targeting chimera) with Kd of 34 nM, 4.7 nM, 8.3 nM, 7.6 nM, 9.6 nM, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and BRD4(2), respectively. |
| S8297 |
ARV-825 |
ARV-825 is a BRD4 Inhibitor that recruits BRD4 to the E3 ubiquitin ligase cereblon, leading to fast, efficient, and prolonged degradation of BRD4 and sustained down-regulation of MYC. |
| S5434 |
AS057278 |
AS057278 (3-Methylpyrazole-5-carboxylic acid, MPC) is an inhibitor of D-amino acid oxidase (DAAO). |
| E0347 |
AS1269574 |
AS 1269574, a small-molecule G protein-coupled receptor 119 (GPR119) agonist, has an EC50 of 2.5 μM in HEK293 cells transiently expressing human GPR119 and enhances insulin secretion in the mouse pancreatic β-cell line MIN-6 only under high-glucose (16.8 mM) conditions. |
| S8685 |
AS1517499 |
AS1517499 is a novel and potent STAT6 inhibitor with an IC50 value of 21 nM. |
| F0418 |
AS160 Rabbit mAb |
AS160,AS160 (Rab-GAP) |
| S8222 |
AS1842856 |
AS1842856 is a cell-permeable inhibitor that blocks the transcription activity of Foxo1 with IC50 of 33 nM. It could directly bind to the active Foxo1, but not the Ser256-phosphorylated form. AS1842856 suppresses autophagy. |
| E0400 |
AS1949490 |
AS1949490, a competitive inhibitor of 5'-lipid phosphatase SHIP2 with IC50 values of 0.62 µM and 0.34 µM for human (Ki value is 0.44 µM) and mouse respectively, promotes protein kinase C-dependent stabilization of brain-derived neurotrophic factor mRNA in cultured cortical neurons.
|
| S8903 |
AS2863619 |
AS2863619 is a small-molecule cyclin-dependent kinase CDK8/19 inhibitor with IC50 of 0.6099 nM and 4.277 nM, respectively. AS2863619 is a potent Foxp3 inducer in Tconv cells. |
| E1656 |
AS601245 |
AS601245 is an orally active, selective, ATP-competitive JNK (c-Jun NH2-terminal protein kinase) inhibitor with IC50 of 150, 220, and 70 nM for three JNK human isoforms hJNK1, hJNK2, and hJNK3, respectively. |
| E3002 |
Asafetida Extract |
Asafetida Extract is derived from factice resin of Ferula sinkiangensis K. M. Shen or Ferula fukanensis K. M. Shen, which is effective in destroying intestinal worms, treatment of parasite-induced malnutrition, swelling pain in stomach and abdomen, abdominal mass, cold, malaria, diarrhea, and prevention of measles. |
| E5912 |
Asandeutertinib |
Asandeutertinib (Osimertinib-d3, AZD-9291-d3) is an orally administered, ATP-competitive, irreversible, deuterated third-generation Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor (EGFR TKI) and a deuterium-stabilized derivative of osimertinib, with the potential to treat advanced EGFR-mutated NSCLC. |
| S0099 |
Asapiprant |
Asapiprant(S-555739) is a potent and selective DP1 receptor antagonist with a Ki of 0.44 nM, which has potential as a novel therapy for allergic airway diseases. |
| S2531 |
Asaraldehyde |
Asaraldehyde (Asaronaldehyde) is a natural COX-2 inhibitor, exhibiting 17-fold selectivity over COX-1. |
| S5467 |
Asarinin |
Asarinin (Sesamin, Fagarol, Pseudocubebin, Episesamin, Eleutheroside B4), isolated as a racemate from the shrub Zanthoxylum alatum, is usually used as a dietary fat-reduction supplement. |
| E5579 |
Asatone |
Asatone is an active component isolated from Radix et Rhizoma Asari, with anti-inflammatory effect via activation of NF-κB and donwn regulation of p-MAPK (ERK, JNK and p38) pathways. |
| F3360 |
ASC/TMS1 (E8J14) Rabbit mAb |
|
| F0468 |
ASC/TMS1 Rabbit mAb |
ASC,ASC/TMS1,ASC/TMS1/PYCARD,TMS1/ASC |
| S8555 |
Asciminib (ABL001) |
Asciminib (ABL001) is a potent and selective allosteric ABL1 inhibitor with dissociation constant (Kd) of 0.5-0.8 nM and selectivity to the myristoyl pocket of ABL1. |
| S7411 |
Ascomycin (FK520) |
Ascomycin (FK520, FR 900520, Immunomycin), an FK-506 analog, is a neutral macrolide immunosuppressant, which prevents rejection after an organ transplant. Phase 3. |
| F0619 |
ASCT2 Rabbit mAb |
ASCT2,SLC1A5/ASCT2 |
| E4930 |
Asenapine |
Asenapine(Org 5222, HSDB8061) is a multi-target receptor antagonist. It acts as an antagonist of serotonin receptors with pKi values of 8.4-10.5, adrenoceptors with pKi values of 8.9-9.5, dopamine receptors with pKi values of 8.9-9.4 and histamine receptors with pKi values of 8.2-9.0. |
| S1283 |
Asenapine maleate |
Asenapine maleate (Org 5222) is a high-affinity antagonist of serotonin, norepinephrine, dopamine and histamine receptors, used for the treatment of schizophrenia and acute mania associated with bipolar disorder. |
| F0772 |
ASF1A Rabbit mAb |
|
| E3567 |
Ash bark Extract |
Ash Bark Extract is extracted from the bark of Fraxinus chinensis, which has anti-Inflammatory effect. |
| F0873 |
ASH2L Rabbit mAb |
|
| E3484 |
Ashitaba Extract |
Ashitaba Extract is extracted fromAngelica keiskei, which can prevent adiposity through modulating lipid metabolism in adipose tissue and the liver. |
| S2266 |
Asiatic Acid |
Asiatic acid (Dammarolic acid, Asiantic acid) is the aglycone of asiaticoside isolated from the plant Centella asiatica, commonly used in wound healing. |
| S3616 |
Asiaticoside |
Asiaticoside (Ba 2742, BRN0078195, CCRIS8995, NSC166062, Emdecassol,Madecassol), the major active principle of Centella asiatica, prevents ultraviolet A-dependent photoaging by suppressing ultraviolet A-induced reactive oxygen species production. It also decreases DNA binding by MITF.
|
| E0241 |
Asiaticoside B |
Asiaticoside B is a triterpene glycoside isolated from Centella asiatica (L.) Urban, with anti-cancer activity.
|
| S0009 |
Asimadoline hydrochloride |
Asimadoline hydrochloride (EMD-61753 hydrochloride) is an orally active, selective and peripherally active κ-opioid agonist with IC50s of 5.6 nM (guinea pig) and 1.2 nM (human recombinant). |
| F1172 |
ASK1 Rabbit mAb |
ASK 1,ASK1 |
| E2379 |
ASK1-IN-2 |
ASK1-IN-2 is a potent and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 32.8 nM. |
| S9975 |
ASN007 |
ASN007(ERAS 007, ERK-IN-3) is a potent and orally active inhibitor of ERK. ERK-IN-3 inhibits ERK1/2 with 2 nM IC50 values. ERK-IN-3 can be used for the research of cancers driven by RAS mutations. |
| S6749 |
ASP-9521 |
ASP-9521 is a selective, orally bioavailable inhibitor of 17beta-hydroxysteroid dehydrogenase type 5 (17β-HSD5), also known as aldo-keto reductase family 1 member C3 (AKR1C3). |
| E1071 |
ASP2453 |
ASP2453, a potent, selective and covalent KRAS G12C inhibitor, inhibits the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf. ASP2453 is a potential therapeutic agent for KRAS G12C-mutated cancer. |
| S8054 |
ASP3026 |
ASP3026 is a novel and selective inhibitor for ALK with IC50 of 3.5 nM. Phase 1. |
| S8953 |
ASP4132 |
ASP4132 is a potent and orally active activator of Adenosine Monophosphate-Activated Protein Kinase (AMPK) with EC50 of 0.018 μM. ASP4132 is used as a clinical candidate for the treatment of human cancer. |
| S6539 |
ASP5878 |
ASP5878 is a novel FGFR-selective inhibitor with IC50 values of 0.47, 0.60, 0.74, and 3.5 nmol/L for recombinant FGFR1, 2, 3, and 4, respectively. |
| S0447 |
ASP7663 |
ASP7663 is an orally bioavailable selective activator of transient receptor potential ankyrin 1 (TRPA1). ASP7663 activates human, rat and mouse TRPA1 receptors with EC50 of 510 nM, 540 nM and 500 nM, respectively. ASP7663 acts by stimulating 5-HT release from QGP-1 cells and exhibiting an abdominal analgesic effect in vivo. |
| E3431 |
Asparagus Extract |
Asparagus Extract is extracted from Asparagus officinalis, which contains adaptogenic, neuroprotective, antioxidant, anti-inflammatory, and nootropic activity. |
| E7976 |
Asparagusic acid |
Asparagusic acid is a sulfur-containing flavor component produced by Asparagus officinalis Linn., with anti-parasitic effect. Asparagusic acid is a plant growth inhibitor. |
| S2036 |
Aspartame |
Aspartame (SC-18862,Nutrasweet) is an artificial, non-saccharide sweetener used as a sugar substitute in some foods and beverages. |
| F3615 |
Aspartate Aminotransferase + FABP-1 Rabbit mAb |
|
| A5930 |
Aspartate Aminotransferase Rabbit Recombinant mAb |
Aspartate Aminotransferase Rabbit Recombinant mAb detects endogenous levels of total Aspartate Aminotransferase. |
| E3804 |
Aspen Flower Extract |
Aspen Flower Extract is derived from the dried flower of Populus tomentosa Carr. or Populus canadensis Moench. |
| S9051 |
Asperuloside |
Asperuloside, an iridoid glycoside found in Herba Paederiae, is a component from traditional Chinese herbal medicine and exerts anti-inflammatory effect. |
| S3017 |
Aspirin |
Aspirin is a salicylate, and irreversible COX1 and COX2 inhibitor, used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication. Aspirin induces autophagy and stimulates mitophagy. |
| A5704 |
ASPP2 Rabbit Recombinant mAb |
ASPP2 Rabbit Recombinant mAb detects endogenous level of total ASPP2. |
| E0822 |
AST-1306 |
AST-1306 (Allitinib) is an orally active and irreversible EGFR, ErbB2 and inhibitor with IC50s of 0.5, 3 and 0.8 nM, respectively. |
| S6662 |
AST-487 (NVP-AST487) |
AST-487 (NVP-AST487), a N,N'-diphenyl urea,is an ATP competitive inhibitor of Flt3 with ki of 0.12 μM.Besides FLT3, AST487 also inhibits RET,KDR,c-KIT,and c-ABL kinase with IC50 values below 1 μM. |
| S5984 |
AST5902 trimesylate |
AST5902 is the principal metabolite of alflutinib both in vitro and in vivo, which exerts remarkable antineoplastic activity similar to alflutinib. AST5902 exhibits much weak CYP3A4 induction potential compared to alflutinib. |
| S3834 |
Astaxanthin |
Astaxanthin (β-Carotene-4,4'-dione, Trans-Astaxanthin), a xanthophyll carotenoid, is a nutrient with unique cell membrane actions and diverse clinical benefits with excellent safety and tolerability. Astaxanthin, a red dietary carotenoid isolated from Haematococcus pluvialis, is a modulator of PPARγ and a potent antioxidant with antiproliferative, neuroprotective and anti-inflammatory activity. |
| S0398 |
Astemizole |
Astemizole (R 43512) is a histamine H1-receptor antagonist with IC50 of 4.7 nM. Astemizole is also a potent inhibitor of ether à-go-go 1 (Eag1) and Eag-related gene (Erg) potassium channels. Astemizole has antineoplastic and antipruritic effects. |
| S3932 |
Astilbin |
Astilbin (Isoastilbin, Neoastilbin, Neoisoastilbin, Taxifolin 3-O-rhamnoside), a flavonoid compound isolated from the rhizome of Smilax glabra Roxb, displays anticancer, antioxidative, anti-inflammatory, and immunosuppressive activities. |
| S9289 |
Astragalin |
Astragalin (kaempferol-3-glucoside, Kaempferol 3-O-glucoside, Kaempferol 3-D-glucoside), a flavonoid from leaves of persimmon and green tea seeds, has anti-tumor, anti-inflammatory and anti-oxidant activities. |
| S3901 |
Astragaloside IV |
Astragaloside IV (AST-IV, AS-IV) is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine. It has various effect on the cardiovascular, immune, digestive, and nervous systems. AS-IV suppresses activation of p-Akt, p-mTOR, p-NF-κB and p-Erk1/2. |
| S9014 |
AstragalosideⅠ |
AstragalosideⅠ, is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine. |
| S3906 |
Astragalus polyphenols |
Astragalus polyphenols(2,3,5,4'-Tetrahydroxystilbene-2-O-beta-D-glucopyranoside) is a wonderful immune enhancing herb that has strong anti-viral activity and produces extra interferon in the body. It contains rich polyphenol with various effects including antioxidant and antiinflammatory actions. |
| E3315 |
Astragalus rhizome Extract |
Astragalus Rhizome Extract, isolated from the rhizome of Radix Astragali, contains main constituents of polysaccharides, flavonoids, and saponins, amino acids and trace elements, with anti-inflammatory, immunomodulation, anti-oxidant, and anticancer effects. |
| E7267 |
Astressin |
Astressin is a potent corticotropin releasing factor (CRF) antagonist. |
| S0872 |
ASTX-029 |
ASTX-029 is an orally bioavailable inhibitor of the extracellular signal-regulated kinases (ERK) 1 and 2, with potential antineoplastic activity. ASTX-029 inhibits ERK-dependent tumor cell proliferation and survival. |
| S4935 |
Asunaprevir |
Asunaprevir is an orally bioavailable inhibitor of the hepatitis C virus enzyme serine protease NS3 that is necessary for protein processing required for viral replication. |
| E5776 |
Asymmetric dimethylarginine |
Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS). It also functions as a marker of endothelial dysfunction in several pathological states. |
| S9678 |
AT-56 |
AT-56 is an orally active and selective inhibitor of lipocalin-type prostaglandin (PG) D synthase (L-PGDS) with Ki of 75 μM and IC50 of 95 μM. |
| S7563 |
AT13148 |
AT13148 is an oral, ATP-competitive, multi-AGC kinase inhibitor with IC50 of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for Akt1/2/3, p70S6K, PKA, and ROCKI/II, respectively. Phase 1.
|
| S1524 |
AT7519 |
AT7519 is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM. It is less potent to CDK3 and little active to CDK7. AT7519 also decrease GSK3β phosphorylation. AT7519 induces apoptosis. Phase 2. |
| S7808 |
AT7519 HCl |
AT7519 HCl is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM in cell-free assays. It is less potent to CDK3 and little active to CDK7. Phase 2.
|
| S1558 |
AT7867 |
AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM in cell-free assays, respectively; little activity outside the AGC kinase family. |
| E5812 |
AT791 |
AT791 is a potent and orally bioavailable inhibitor of TLR7 and TLR9 with an IC50 of 3.33 μM and 0.04 μM, respectively, in human embryonic kidney cells and also inhibits DNA-TLR9 interaction in vitro. |
| S1134 |
AT9283 |
AT9283 is a potent JAK2/3 inhibitor with IC50 of 1.2 nM/1.1 nM in cell-free assays; also potent to Aurora A/B, Abl1(T315I). |
| S6003 |
Ataluren (PTC124) |
Ataluren (PTC124) selectively induces ribosomal read-through of premature but not normal termination codons, with EC50 of 0.1 μM in HEK293 cells, may provide treatment for genetic disorders caused by nonsense mutations (e.g. CF caused by CFTR nonsense mutation). Phase 3. |
| S8993 |
Atamparib (RBN-2397) |
Atamparib (RBN-2397) is a potent, selective and orally active NAD+ competitive inhibitor PARP7 with IC50 of <3 nM and Kd of <0.001 μM. RBN-2397 has the potential for the research of tumor treatment. |
| S4662 |
Atazanavir |
Atazanavir (Latazanavir, Zrivada, Reyataz, BMS-232632) is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. Atazanavir is a substrate and inhibitor of cytochrome P450 isozyme 3A (CYP3A4) and an inhibitor and inducer of P-glycoprotein. |
| S1457 |
Atazanavir (BMS-232632) Sulfate |
Atazanavir Sulfate (BMS-232632-05, Reyataz) is a HIV protease inhibitor with Ki of 2.66 nM in a cell-free assay. |
| S6615 |
ATB 346 |
ATB 346, a novel hydrogen sulphide-releasing derivative of naproxen with remarkably reduced toxicity, inhibits COX activity. ATB 346 is an anti-inflammatory agent that induces apoptosis of human melanoma cells. |
| E8305 |
ATC-324 |
ATC-324 is a potent AUTOphagy-TArgeting Chimera (AUTOTAC) degrader of androgen receptor (AR) with a DC50 of 2.05 µM. It induces autophagy–lysosomal degradation of AR, reduces nuclear AR and AR-V7 activity, and causes cytotoxicity in AR-positive prostate cancer cells, making it useful for prostate cancer research. |
| S4817 |
Atenolol |
Atenolol (Tenormin, Normiten, Blokium) is a selective β1 receptor antagonist with log Kd values of −6.66±0.05, −5.99±0.14, −4.11±0.07 for binding to the human β1-, β2- and β3-adrenoceptors. |
| A2004 |
Atezolizumab (anti-PD-L1) |
Atezolizumab (anti-PD-L1) is a fully humanized, IgG1 monoclonal antibody that blocks the interaction of PD-L1 with both PD-1 and B7.1, but not the interaction of PD-L2 with PD-1. MW : 145 KD. |
| F1457 |
ATF-2 Rabbit mAb |
ATF2,ATF-2 |
| F0318 |
ATF-4 Rabbit mAb |
ATF4,ATF-4,CREB-2/ATF-4 |
| A5083 |
ATF1 Rabbit Recombinant mAb |
ATF1 Rabbit Recombinant mAb detects endogenous levels of ATF1. |
| E6458 |
ATF3 inducer 1 |
|
| F1121 |
ATF3 Rabbit mAb |
ATF3,ATF-3 |
| F2768 |
ATF5 Rabbit mAb |
|
| F0822 |
ATF6 Mouse mAb |
ATF6,ATF-6,ATF-6α |
| F0877 |
Atg101 Rabbit mAb |
|
| F2883 |
ATG12 (H1K12) Rabbit mAb |
|
| F0272 |
Atg12 Rabbit mAb |
|
| F0719 |
Atg13 Rabbit mAb |
Atg13,KIAA0652/ATG13 |
| F0273 |
Atg16L1 Rabbit mAb |
|
| A5152 |
Atg16L1 Rabbit Recombinant mAb |
Atg16L1 Rabbit Recombinant mAb detects endogenous level of Atg16L1. |
| F1073 |
ATG4A Rabbit mAb |
|
| F1446 |
Atg4B Rabbit mAb |
|
| A5528 |
Atg4C Rabbit Recombinant mAb |
Atg4C Rabbit Recombinant mAb detects endogenous level of total Atg4C. |
| A5745 |
ATG5 Rabbit Recombinant mAb |
ATG5 Rabbit Recombinant mAb detects endogenous levels of ATG5. |
| F1173 |
ATG9A Rabbit mAb |
|
| F3255 |
ATGL (A12G17) Rabbit mAb |
Adipose Triglyceride Lipase,ATGL |
| F0419 |
ATGL Rabbit mAb |
Adipose Triglyceride Lipase,ATGL |
| S8309 |
ATI-2341 |
ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. |
| E4647 |
Aticaprant |
Aticaprant (CERC-501, LY-2456302) is a potent, orally bioavailable, centrally-penetrant antagonist of the kappa opioid receptor with a Ki of 0.807 nM. It exhibits an antidepressant effect with the potential to treat major depressive disorder (MDD). |
| S4650 |
Atipamezole |
Atipamezole (MPV-1248, MPV1248, Antisedan) is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug. |
| S4649 |
Atipamezole hydrochloride |
Atipamezole (Antisedan, MPV1248) is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug. Atipamezole hydrochloride is hydrochloride form of atipamezole. |
| F2951 |
ATM (M23L2) Rabbit mAb |
|
| S8454 |
ATN-161 |
ATN-161 is a novel small peptide antagonist of integrin α5β1. It binds to several integrins, including α5β1 and αvβ3, that play a role in angiogenesis and tumor progression.
|
| E7527 |
ATN-224 |
ATN-224 is a second-generation tetrathiomolybdate analogue and an orally active inhibitor of Cu2+/Zn2+-superoxide dismutase 1 (SOD1) with an IC50 of 17.5 nM. It inhibits angiogenesis and tumor growth and can be used in advanced solid and advanced hematologic malignancies research. |
| E1980 |
Atogepant |
Atogepant(MK-8031, AGN-241689) is a potent, selective, orally available antagonist of the calcitonin gene-related peptide (CGRP) receptor, with ki of 0.026 nM for human CGRP receptor. It is used for the preventive treatment episodic migraine. |
| S3175 |
Atomoxetine HCl |
Atomoxetine (LY 139603) is a selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM, with 15- and 290-fold lower affinity for human 5-HT and DA transporters. |
| S0342 |
Atopaxar |
Atopaxar(E5555,ER-172594-00) is a potent, orally active, selective and reversible thrombin receptor protease-activated receptor-1 (PAR-1) antagonist. |
| S5715 |
Atorvastatin |
Atorvastatin is a lipid lowering agent. It is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway. Atorvastatin activates autophagy. |
| S2077 |
Atorvastatin Calcium |
Atorvastatin Calcium is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol. Atorvastatin Calcium induces apoptosis and autophagy. |
| E4792 |
Atorvastatin calcium hydrate |
Atorvastatin calcium hydrate (Totalip) is a potent inhibitor of the HMG-CoA reductase . It is used as a potent hypolipidemic agent to reduce the elevated total-cholesterol, low-density lipoprotein (LDL), apolipoprotein B (apo B), and triglyceride (TG) levels, and to increase the high-density lipoprotein cholesterol (HDL-C) level in patients with primary hypercholesterolemia and mixed dyslipidemia. |
| P1025 |
Atosiban |
Atosiban is a competitive oxytocin and vasopressin antagonist by exhibiting high affinity for both receptors. It is used to treat preterm labors. |
| E7270 |
Atosiban acetate |
Atosiban acetate (RW22164 acetate;RWJ22164 acetate) is a nonapeptide competitive vasopressin/oxytocin receptor antagonist, and is a desamino-oxytocin analogue. Atosiban is the main tocolytic agent and has the potential for spontaneous preterm labor research. |
| S3079 |
Atovaquone |
Atovaquone (Atavaquone) is a medication used to treat or prevent for pneumocystis pneumonia, toxoplasmosis, malaria, and babesia. |
| S5260 |
ATP |
ATP (Adenosine-Triphosphate, Adenosine 5'-triphosphate) is a multifunctional nucleoside triphosphate and an important endogenous signaling molecule in immunity and inflammation. |
| F1174 |
ATP citrate lyase Rabbit mAb |
ATP citrate lyase,ATP-Citrate Lyase |
| E6072 |
ATP dimagnesium |
ATP dimagnesium (Adenosine 5'-triphosphate dimagnesium) is a central molecule in energy metabolism, driving cellular pumps and acting as a coenzyme. It also functions as an endogenous signaling molecule that modulates immune responses and activates the NLRP3 inflammasome, contributing to host defense during bacterial infections. |
| S1985 |
ATP disodium |
ATP disodium is a disodium salt form of adenosine-triphosphate which is a multifunctional nucleoside triphosphate. |
| E4964 |
ATP disodium trihydrate |
ATP disodium trihydrate, is the primary energy currency of the cell, essential for intracellular energy metabolism. It regulates extracellular biological processes, including cardiac function, neurotransmission, muscle contraction, vasodilation, bone and liver glycogen metabolism, and inflammation. It also plays a crucial role in initiating immune responses during infections. |
| F1587 |
ATP5A Mouse mAb |
ATP5A,ATP5A1 |
| A5288 |
ATP5A1 Rabbit Recombinant mAb |
ATP5A1 Rabbit Recombinant mAb detects endogenous level of total ATP5A1. |
| F3127 |
ATP5C1 Mouse mAb |
|
| F2807 |
ATP5G1/G2/G3 Rabbit mAb |
|
| F2084 |
ATP5O Mouse mAb |
|
| F2040 |
ATP6V0D1/P39 Rabbit mAb |
|
| F2840 |
ATP6V1A Rabbit mAb |
|
| F3467 |
ATP6V1B1 + ATP6V1B2 Rabbit mAb |
ATP6V1B1 + ATP6V1B2,V-ATPase B1/2 |
| F1611 |
ATPB Mouse mAb |
ATP Synthase beta,ATPB |
| E7786 |
ATPγS tetralithium salt |
ATPγS (tetralithium salt) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. |
| F0773 |
ATR Rabbit mAb |
|
| S9314 |
Atractylenolide II |
Atractylenolide II (AT-II, Asterolide, 2-Atractylenolide), a major sesquiterpenoids isolated from the dried Rhizome of Atractylodes macrocephala, shows a wide range of biological and pharmacological activities, for example, against insomnia and anxiety, neuroprotective, platelet activation and anti-cancer effect. |
| E0008 |
Atractylodin |
Atractylodin (Atractydin) is one of the major constituents of the rhizome of Atractylodes lancea and inhibits N-acylethanolamine-hydrolyzing acid amidase (NAAA) activity with an IC50 of 2.81 µM. Atractylodin also inhibits interleukin-6 (IL-6) by blocking NPM-ALK activation and MAPKs. |
| E3075 |
Atractylodis Rhizoma Extract |
Atractylodis Rhizoma Extract is extracted from Atractylodes macrocephala, which has functions including treating hypofunction of the spleen with the loss of appetite, abdominal distension diarrhea, phlegm drink dizziness palpitation, edema, fetal movement restless. |
| E3032 |
Atractyloides Macrocephala Root Extract |
Atractyloides Macrocephala Root Extract is extracted from Atractylodes macrocephala Koidz., which can regulate lysophagy based on LKB1-AMPK-TFEB pathway. |
| S3264 |
Atractyloside potassium salt |
Atractyloside potassium salt (ATR potassium salt), a toxic diterpenoid glycoside isolated from the fruits of Xanthium sibiricum (Cang'erzi), is a powerful and specific inhibitor of mitochondrial ADP/ATP carriers. Atractyloside potassium salt inhibits chloride channels from mitochondrial membranes of rat heart. |
| S1832 |
Atracurium Besylate |
Atracurium Besylate (BW 33A, 51W89) is a neuromuscular blocking agent with ED95 of 0.2 mg/kg. |
| E7301 |
Atrasentan |
Atrasentan (ABT-627, (+)-A 127722, A-147627) is an antagonist of endothelin A (ETA) receptor with a Ki of 0.034 nM. It exhibits antitumor activity by inhibiting prostate cancer cell growth and inducing apoptotic cell death. |
| E1562 |
Atrasentan hydrochloride |
Atrasentan hydrochloride (ABT-627 hydrochloride) is a selective endothelin A receptor antagonist with an IC50 of 0.0551 nM for ETA. |
| S5171 |
Atrazine |
Atrazine (Chromozin, Oleogesaprim, Aktikon, Gesaprim) is a selective triazine herbicide. Atrazine is also a potent endocrine disruptor that is active at low, ecologically relevant concentrations. |
| S4713 |
Atropine |
Atropine (Atropen, Atnaa, Tropine tropate, DL-Hyoscyamine) is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with anti-myopia effect. |
| S5493 |
Atropine sulfate |
Atropine Sulfate (Sulfatropinol, Atropette, Tropintran) is the sulfate salt of atropine, which is a natural alkaloid anticholinergic agent and has potent antimuscarinic effects. |
| S2130 |
Atropine sulfate monohydrate |
Atropine sulfate monohydrate is a competitive antagonist for the muscarinic acetylcholine receptor, used to decrease the production of saliva and secretions of the airway prior to surgery. |
| E0320 |
Atuliflapon (AZD5718) |
Atuliflapon (AZD5718) is an oral inhibitor of (FLAP) 5-lipoxygenase activating protein with an IC50 of 2.0 nM. It has the potential to treat coronary artery disease. |
| S8727 |
Atuveciclib (BAY-1143572) |
Atuveciclib (BAY-1143572) is a potent and highly selective PTEFb/CDK9 inhibitor with IC50 values of 13 nM for CDK9/CycT and the ratio of IC50 values for CDK2/CDK9 is about 100. Outside the CDK family, It inhibits GSK3 kinase with IC50 values of 45 nM and 87 nM for GSK3α and GSK3β respectively. |
| E8281 |
ATUX-1215 |
ATUX-1215 is an orally bioavailable diarylmethyl-4-aminopyran sulfonamide that activates protein phosphatase 2A (PP2A) by stabilizing AC heterodimers and promoting heterotrimer formation with B subunits. It restores suppressed PP2A activity in IPF models, improving lung function, reducing collagen deposition, and downregulating fibrotic cytokines. ATUX-1215 also exhibits potent antifibrotic effects. |
| E1611 |
Atuzabrutinib |
Atuzabrutinib (SAR 444727, PRN473) is a reversible, selective inhibitor of Bruton's tyrosine kinase (Btk). It can effectively prevent neutrophil recruitment via inhibition of macrophage antigen‐1 signalling. |
| E5836 |
ATX968 |
ATX968 (DHX9-IN-2) is a potent, selective, and orally bioavailable inhibitor of DHX9 helicase with an IC50 of 8 nM. It induces strong and sustained tumor growth inhibition or regression in MSI-H/dMMR colorectal cancer (CRC) xenograft models. |
| E1103 |
AU-15330 |
AU-15330 is a proteolysis-targeting chimera (PROTAC) degrader of the SWI/SNF ATPase subunits, SMARCA2 and SMARCA4, which can induce potent inhibition of tumor growth in xenograft models of prostate cancer. |
| S0464 |
AU1235 |
AU1235, an adamantyl urea, is a potent inhibitor of Mycobacterium tuberculosis protein MmpL3.
|
| S5459 |
Aucubin |
Aucubin (Rhinanthin), an iridoid glycoside existing in medicinal plants, has been reported to show an anti-inflammatory activity by suppression of TNF-α production in murine macrophages. |
| S0752 |
AUDA |
AUDA (compound 43) is a potent inhibitor of soluble epoxide hydrolase (sEH) with IC50 of 18 nM and 69 nM for the mouse sEH and human sEH, respectively. AUDA has anti-inflammatory activity that reduces the protein expression of MMP-9, IL-1β, TNF-α and TGF-β. AUDA downregulates Smad3 and p38 signaling pathways. |
| S8549 |
AUNP-12 |
AUNP-12 (Aur-012, Aurigene-012, Aurigene NP-12), a new immune checkpoint modulator, is an inhibitor of the PD-1 pathway. |
| E6080 |
AUR1545 |
AUR1545 is a potent and selective degrader of KAT2A and KAT2B. It exhibits an anti-proliferative effect and significantly inhibits tumor growth in an NCI-H1048 xenograft model. |
| S4307 |
Auranofin |
Auranofin is an inhibitor of thioredoxin reductase (TrxR) with IC50 of 88 nM for purified H. pylori TrxR in cell-free assay. Auranofin has anti-cancer activity and can completely inhibit bacterial growth at 1.2 μM. Auranofin is an FDA-approved gold-containing compound used for the treatment of rheumatoid arthritis. |
| E7344 |
Aurantiamide acetate |
Aurantiamide acetate (TMC-58A) is a selective and orally active cathepsin inhibitor isolated from?Portulaca oleracea L. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of ?inflammatory?diseases. |
| S9052 |
Auraptene |
Auraptene (7-geranyloxycoumarin) is a natural coumarin derived from citrus plants and possesses valuable pharmacological properties, including anticarcinogenic, anti-inflammatory, antihelicobacter, antigenotoxic, and neuroprotective effects. Auraptene inhibits matrix metalloproteinase 2 (MMP-2) as well as key inflammatory mediators, including IL-6, IL-8 and chemokine (C-C motif) ligand-5(CCL5). |
| E7319 |
Aureobasidin A |
Aureobasidin A (Basifungin) is a cyclic peptide antibiotic with oral activity. Aureobasidin A is an inhibitor of inositol phosphorylated ceramide synthetase AUR1. Aureobasidin A has antifungal and antiparasitic activity. |
| E3521 |
Auricledleaf Swallowwort Root Extract |
Auricledleaf Swallowwort Root Extract is obtained from Cynanchum otophyllum Schneid., which may be mediated by activation of PPARα and TFEB, and the subsequent autophagy-lysosomal pathway enhancement, thus attenuate Alzheimer’s disease pathology and improve cognitive function in 3XTg mice. |
| E7266 |
Aurintricarboxylic acid |
Aurintricarboxylic acid is a potent, selective allosteric antagonist of P2X1R and P2X3R, with IC50 of 8.6 nM and 72.9 nM, respectively. It also functions as an anti-influenza agent by inhibiting viral neuraminidase. Aurintricarboxylic acid suppresses apoptosis and is a potent inhibitor of topoisomerase II with an ID50 of ~7 nM in relaxation assays. |
| F1175 |
Aurora A Mouse mAb |
Aurora A,Aurora A/AIK,Aurora-A Kinase |
| A5118 |
Aurora B Rabbit Recombinant mAb |
Aurora B Rabbit Recombinant mAb detects endogenous levels of total Aurora B. |
| E0342 |
Aurora kinase Inhibitor II |
Aurora kinase inhibitor II, an anilinoquinazoline that is both a potent and selective ATP-competitive inhibitor of Aurora kinase (ARK), has the ability to permeate the cell and is involved in the regulation of the cell cycle, particularly cell division. |
| S2931 |
Aurora Kinase Inhibitor III |
Aurora kinase inhibitor III is a potent inhibitor of Aurora A kinase with an IC50 of 42 nM and has high selectivity for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR (IC50s = 386, 3,550, 591, 1,980, 2,510, 887, and >10,000 nM, respectively). |
| E7941 |
Aurothioglucose |
Aurothioglucose (Gold thioglucose), containing monovalent gold ion, is a potent active-site inhibitor of TrxR1 (thioredoxin reductase 1), with an IC50 of 65 nM. Aurothioglucose inhibits the DNA binding of NF-κB in vitro. Aurothioglucose shows anti-HIV and anti-rheumatic activities. |
| P1159 |
Autocamtide 2, amide |
Autocamtide 2, amide is a substrate for Calcium/Calmodulin Stimulated Protein Kinase (CaMK) family assays. |
| L2600 |
Autophagy Compound Library |
A unique collection of 1019 small molecules with autophagy-inducing or autophagy-inhibiting activity. |
| S8596 |
Autophinib |
Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and rapamycin induced autophagy assay. The IC50 value for Vps34 is 19 nM in vitro.
|
| S6960 |
Auxinole |
Auxinole is a potent auxin antagonist that binds to TIR1 and blocks the formation of the TIR1-IAA-Aux/IAA complex. Auxinole is an OsTIR1 inhibitor that suppresses leaky degradation of degron-fused proteins. |
| S2733 |
AV-412 free base |
AV-412 free base (MP-412 free base) is an EGFR inhibitor with IC50s of 0.75, 0.51, 0.79, 2.30, 19 nM for EGFR, EGFRL858R, EGFRT790M, EGFRL858R/T790M and ErbB2, respectively. |
| S0474 |
Avacopan |
Avacopan is an orally administered and selective C5a receptor (C5aR) antagonist. |
| S7892 |
Avadomide (CC-122) |
Avadomide (CC-122), a new chemical entity termed pleiotropic pathway modifier, is a novel agent for Diffuse large B-cell lymphoma(DLBCL) with antitumor and immunomodulatory activity. Its molecular target is the protein cereblon (CRBN), a substrate receptor of the cullin ring E3 ubiquitin ligase complex CRL4CRBN. |
| S1262 |
Avagacestat (BMS-708163) |
Avagacestat (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2. |
| S4019 |
Avanafil |
Avanafil is a highly selective PDE5 inhibitor with IC50 of 5.2 nM, >121-fold selectivity over other PDEs. |
| S8553 |
Avapritinib |
Avapritinib is a small molecule kinase inhibitor that potently inhibits PDGFRα D842V mutant activity in vitro (IC50 = 0.5 nM) and PDGFRα D842V autophosphorylation in the cellular setting (IC50 = 30 nM); also a potent inhibitor of the analogous Kit (c-Kit) mutation, D816V in Kit (c-Kit) Exon 17 (IC50 = 0.5 nM). |
| S2187 |
Avasimibe |
Avasimibe inhibits ACAT with IC50 of 3.3 μM, also inhibits human P450 isoenzymes CYP2C9, CYP1A2 and CYP2C19 with IC50 of 2.9 μM, 13.9 μM and 26.5 μM, respectively. |
| S6624 |
Avatrombopag |
Avatrombopag (AKR-501,E5501,YM477) is an orally administered, small-molecule thrombopoietin receptor (c-Mpl) agonist which increases platelet number, but not platelet activation. |
| E4969 |
Avatrombopag hydrochloride |
Avatrombopag hydrochloride(AKR-501 hydrochloride, YM477 hydrochloride) is an orally administered second generation agonist of Thrombopoietin receptor(TpoR) with an EC50 value of 3.3 nM. It is used in the treatment of primary chronic immune thrombocytopenia (ITP). |
| E1060 |
AVE 0991 |
AVE 0991 is a nonpeptide and orally active angiotensin-(1-7) receptor agonist with an IC50 of 21 nM. |
| A2015 |
Avelumab (anti-PD-L1) |
Avelumab (anti-PD-L1) (MSB0010718C) is a fully human IgG1 monoclonal antibody that targets the protein programmed death-ligand 1 (PD-L1). Avelumab exhibits potential antibody-dependent cell-mediated cytotoxicity and is used for the treatment of several kinds of carcinoma. MW=143.8 kDa. |
| E3798 |
Avena Sativa L. Extract |
Avena Sativa L. Extract is drawed from Avena Sativa L., which has has high antioxidant properties. |
| S4999 |
Avermectin B1 |
Avermectin B1 (Abamectin) is a widely used insecticide and anthelmintic. |
| P1203 |
Avexitide |
Avexitide (Exendin (9-39)amide) is a specific and competitive antagonist of glucagon-like peptide-1 (GLP-1) receptor. |
| E4984 |
Avibactam free acid |
Avibactam free acid(NXL-104 free acid) is a potent, covalent, reversible, non–β-lactam Inhibitor of β-lactamase, inhibiting β-lactamase TEM-1 and CTX-M-15 with an IC50 of 8 nM and 5 nM, respectively. It is useful in research on Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium, Gram-negative infections. |
| S3732 |
Avibactam sodium |
Avibactam (AVE-1330A, NXL104) is a covalent, reversible, non-β-lactam β-lactamase inhibitor with IC50 values of 8, 80, and 38 nM for TEM-1, P99, and KPC-2 β-lactamases, respectively. |
| E4985 |
Avibactam sodium hydrate |
Avibactam sodium hydrate(NXL-104 hydrate) is a covalent and reversible non-β-lactam inhibitor of β-lactamase which inhibits β-lactamase activity with IC50 values of 8 nM for TEM-1 and 5 nM for CTX-M-15, respectively. |
| S8741 |
Avitinib (Abivertinib) |
Avitinib (Abivertinib) is a pyrrolopyrimidine-based irreversible EGFR inhibitor that is mutation-selective with IC50 value of 0.18 nM against EGFR L858R/T790M double mutations, nearly 43-fold greater potency over wild-type EGFR (IC50 value, 7.68 nM). It has comparable anti-tumor activity and tolerated toxicity. |
| E4597 |
Avitinib maleate |
Avitinib maleate(Abivertinib maleate, AC0010 maleate, AC0010MA) is a third-generation, irreversible, and orally active selective inhibitor of EGFR. It displays IC50 values of 0.18 nM, 0.18 nM, 7.68 nM and against EGFR L858R, EGFR T790M, and wild-type EGFR. Avitinib maleate also acts as an inhibitor of BTK that induces apoptosis of BTK in mantle cell lymphoma. |
| E7526 |
AVN-944 |
AVN-944 (VX-944) is an orally active, potent, selective, noncompetitive and specific inhibitor of IMPDH (inosine monophosphate dehydrogenase). AVN-944 is an essential rate-limiting enzyme in de novo guanine nucleotide synthesis. AVN-944 is also an inhibitor of arenavirus RNA synthesis, and blocks arenavirus infection. AVN-944 has broad anti-cancer activities, and can be used for multiple myeloma (MM) and acute myeloid leukemia (AML) research. |
| S1904 |
Avobenzone |
Avobenzone (Butyl methoxydibenzoylmethane, BF2AVB) is an oil soluble ingredient used in sunscreen products to absorb the full spectrum of UVA rays and a dibenzoylmethane derivative. |
| E1605 |
Avotaciclib trihydrochloride |
Avotaciclib trihydrochloride(BEY1107 trihydrochloride) is a potent and orally active inhibitor of cyclin dependent kinase 1 (CDK1). It can be used for the research of locally advanced or metastatic pancreatic cancer. |
| S7170 |
Avutometinib |
Avutometinib(RO5126766,CH5126766,VS 6766, CKI-27, R-7304, RG-7304) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM,19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.
|
| E0614 |
AWL-II-38.3 |
AWL-II-38.3 is a potent Ephrin type-A receptor 3 (EphA3) kinase inhibitor. |
| E0626 |
AX 20017 |
AX 20017 is a small-molecule protein kinase G (PknG) inhibitor with an IC50 of 0.39 μM. |
| S6727 |
AX-024 HCl |
AX-024 HCl blocks the interaction of the CD3ε PRS with SH3.1(Nck). AX-024 HCl also inhibits IL-6, TNF-α, IFN-γ, IL-10 and IL-17A. |
| E1906 |
AX-15836 |
AX-15836 is a potent and selective inhibitor of ERK5 with an IC50 of 8 nM. It can be used to study number of biological processes. |
| F0423 |
Axin1 Rabbit mAb |
|
| S1005 |
Axitinib |
Axitinib is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM in Porcine aorta endothelial cells, respectively. |
| F0178 |
Axl Rabbit mAb |
|
| E1911 |
AY 9944 |
AY 9944 is a potent and specific inhibitor of cholesterol biosynthesis, it inhibits the Δ7-sterol reductase with an IC50 of 13 nM. It can be used in the research to study Smith–Lemli–Opitz syndrome, a frequent inborn disorder of sterol metabolism. |
| S2731 |
AZ 3146 |
AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM, contributes to recruitment of CENP-E (kinesin-related motor protein), less potent to FAK, JNK1, JNK2, and Kit. |
| S2746 |
AZ 628 |
AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM in cell-free assays, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc. AZ628 induces apoptosis. |
| S2214 |
AZ 960 |
AZ 960 is a novel ATP competitive JAK2 inhibitor with IC50 and Ki of <3 nM and 0.45 nM, 3-fold selectivity of AZ960 for JAK2 over JAK3. AZ 960 induces apoptosis and growth arrest. |
| E7504 |
AZ-23 |
AZ-23 is an ATP-competitive and orally bioavailable Trk kinase A/B/C inhibitor with IC50s of 2 nM (TrkA), 8 nM (TrkB), 24 nM (FGFR1), 52 nM (Flt3), 55 nM (Ret), 84 nM (MuSk), 99 nM (Lck), respectively. |
| S0108 |
AZ-33 |
AZ-33 (LDHA Inhibitor 33) is a potent inhibitor of lactate dehydrogenase A (LDHA) with IC50 of 0.5 μM. LDHA is the key enzyme involved in anaerobic glycolysis which is frequently deregulated in human malignancies. |
| S3520 |
AZ10606120 dihydrochloride |
AZ10606120 dihydrochloride (2HCl) is a potent and selective antagonist for P2X7 receptor (P2X7R) with IC50 of ~10 nM. AZ10606120 dihydrochloride exhibits anti-depressant effects and reduces tumour growth. This product is not soluble in PBS solution. Please do not dissolve it in PBS for administration. |
| E2647 |
AZ1495 |
AZ1495 is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively. |
| S7338 |
AZ191 |
AZ191 is a potent and selective DYRK1B inhibitor with IC50 of 17 nM in a cell-free assay, about 5- and 110-fold selectivity over DYRK1A and DYRK2, respectively. |
| S8755 |
AZ304 |
AZ304 is a synthetic inhibitor designed to interact with the ATP-binding site of wild type and V600E mutant BRAF with IC50 values of 79 nM and 38 nM, respectively. It also inhibits CRAF, p38 and CSF1R at sub 100 nM potencies. |
| S8729 |
AZ32 |
AZ32 is a specific inhibitor of the ATM kinase that possesses good BBB penetration in mouse with an IC50 value of <0.0062 μM for ATM enzyme. It shows adequate selectivity over ATR and also has high cell permeability. |
| E5947 |
AZ3246 |
|
| S9744 |
AZ3451 |
AZ3451 is a potent antagonist of protease-activated receptor 2 (PAR2) that binds to a remote allosteric site outside the helical bundle with IC50 of 23 nM. |
| S7042 |
AZ505 |
AZ505 is a potent and selective inhibitor of SMYD2 with an IC50 of 0.12 μM. |
| E8022 |
AZ505 ditrifluoroacetate |
AZ505 ditrifluoroacetate is a potent and selective SMYD2 inhibitor with IC50 of 0.12 μM. |
| S7298 |
AZ5104 |
AZ5104, the demethylated metabolite of AZD-9291, is a potent EGFR inhibitor with IC50 of <1 nM, 6 nM, 1 nM, and 25 nM for EGFR (L858R/T790M), EGFR (L858R), EGFR (L861Q), and EGFR (wildtype), respectively. Phase 1. |
| S6427 |
AZ876 |
AZ876 is a novel high-affinity Liver X Receptor (LXR) agonist with Ki values of 0.007 μM and 0.011 μM for human LXRα and LXRβ respectively. |
| S1782 |
Azacitidine (5-Azacytidine) |
Azacitidine (5-Azacytidine, 5-AzaC, Ladakamycin, AZA, 5-Aza, CC-486,NSC 102816) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases. Azacitidine induces mitochondrial apoptosis and autophagy. |
| S3196 |
Azacyclonol |
Azacyclonol (MER 17, MDL 4829), also known as γ-pipradol, is a drug used to diminish hallucinations in psychotic individuals. |
| S4194 |
Azaguanine-8 |
Azaguanine-8 (NSC-749, SF-337, SK 1150) is a purine analogs showing antineoplastic activity by competing with guanine in the metabolism. |
| S6636 |
Azaindole 1 (BAY-549) |
Azaindole 1 (BAY-549) is a selective Rho-associated protein kinase (ROCK) inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2 in an ATP-competitive manner. |
| S5085 |
Azamethiphos |
Azamethiphos is an organophosphate (OP) pesticide used to combat sea lice infestations in farmed salmonids. |
| S4219 |
Azaperone |
Azaperone (NSC 170976) crosses the blood-brain barrier and binds to both DI and D2 receptors, being an antagonist of Dopamine receptors with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine. |
| S2106 |
Azasetron HCl |
Azasetron HCl (Y-25130) is a selective 5-HT3 receptor antagonist with IC50 of 0.33 nM used in the management of nausea and vomiting induced by cancer chemotherapy. |
| S3186 |
Azatadine dimaleate |
Azatadine (SCH10649,Azatadine Maleate) is an histamine and cholinergic inhibitor with IC50 of 6.5 nM and 10 nM, respectively. |
| S1721 |
Azathioprine |
Azathioprine(BW 57-322) is an immunosuppressive drug, inhibiting purine synthesis and GTP-binding protein Rac1 activation, used in the treatment of organ transplantation and autoimmune diseases. |
| S4978 |
Azathramycin |
Azathramycin (Azaerythromycin A, Azaerythromycin) is a macrolide antibiotic containing cladinose. |
| E7651 |
AZD-0284 |
AZD-0284 is a selective inverse agonist of the nuclear receptor RORγ. AZD-0284 has the potential for plaque psoriasis vulgaris and respiratory tract disorders treatment. |
| E1995 |
AZD-5462 |
AZD-5462(Example 1) is a modulator of RXFP1, the cognate receptor for human relaxin, that belongs to the GPCR family 1c number. AZD-5462 exhibits anti-fibrotic and anti-inflammatory properties. |
| E8173 |
AZD-5991 |
AZD-5991 is a potent and selective Mcl-1 inhibitor with an IC50 of 0.7 nM in FRET assay and a Kd of 0.17 nM in surface plasmon resonance (SPR) assay. |
| E6405 |
AZD0022 |
AZD0022 is a potent, orally bioavailable, selective, reversible inhibitor of KRASG12D that drives robust pathway inhibition and anti-tumour activity in KRASG12D models. |
| E1549 |
AZD0095 |
AZD0095 is a selective and orally active Monocarboxylate transporter 4 (MCT4) inhibitor with IC50 of 1.3 nM and effectively inhibits the tumor growth in NCI-H358 xenografts in combination with Cediranib. |
| S8375 |
AZD0156 |
AZD0156 is a potent and selective inhibitors of ATM kinase, with potential chemo-/radio-sensitizing and antineoplastic activities. AZD0156 prevents DNA damage checkpoint activation, disrupts DNA damage repair, induces tumor cell apoptosis, and leads to cell death of ATM-overexpressing tumor cells. |
| S8708 |
AZD0364 (ATG-017) |
AZD0364 (ATG-017) is a pre-clinical ERK1/2 inhibitor with an IC50 of 0.6 nM for ERK2. |
| E4629 |
AZD0780 |
AZD0780 (Laroprovstat, Pcsk9-IN-12) is an orally potent inhibitor of PCSK9 with a Kd value of <200 nM. It directly binds to PCSK9, blocks its function, and significantly reduces LDL cholesterol levels, making it useful for dyslipidemia research. |
| S7145 |
AZD1080 |
AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor, inhibits human GSK3α and GSK3β with Ki of 6.9 nM and 31 nM, respectively, shows >14-fold selectivity against CDK2, CDK5, CDK1 and Erk2. |
| S1051 |
AZD1152(Barasertib) |
AZD1152 is a selective inhibitor of Aurora B with Ki of 0.36 nM. |
| S7104 |
AZD1208 |
AZD1208 is a potent, and orally available Pim kinase inhibitor with IC50 of 0.4 nM, 5 nM, and 1.9 nM for Pim1, Pim2, and Pim3 in cell-free assays, respectively. AZD1208 induces autophagy, cell cycle arrest and apoptosis. Phase 1. |
| S8680 |
AZD1390 |
AZD1390 is a first-in-class orally available and CNS penetrant ATM inhibitor with an IC50 of 0.78 nM in cells and >10,000-fold selectivity over closely related members of the PIKK family of enzymes and excellent selectivity across a broad panel of kinases. |
| S2162 |
AZD1480 |
AZD1480 is a novel ATP-competitive JAK2 inhibitor with IC50 of 0.26 nM in a cell-free assay, selectivity against JAK3 and Tyk2, and to a smaller extent against JAK1. Phase 1. |
| E1353 |
AZD1656 |
AZD1656 is a potent, selective and orally active activator of glucokinase. AZD1656 has the potential for type 2 diabetes research. |
| S7263 |
AZD1981 |
AZD1981 is a potent, selective CRTh2 (DP2) receptor antagonist with IC50 of 4 nM, showing >1000-fold selectivity over more than 340 other enzymes and receptors, including DP1. Phase 2. |
| S6555 |
AZD2098 |
AZD2098 is a potent and bioavailable CCR4 receptor antagonist with pIC50 of 7.8. |
| E5969 |
AZD2389 |
AZD2389 is a potent, orally active, and selective inhibitor of fibroblast activation protein (FAP) with the potential to treat metabolic dysfunction-associated steatohepatitis. |
| S7029 |
AZD2461 |
AZD2461 is a novel PARP inhibitor with low affinity for Pgp. Phase 1. |
| S7253 |
AZD2858 |
AZD2858 is a selective GSK-3 inhibitor with an IC50 of 68 nM, activating Wnt signaling, increases bone mass in rats. |
| S8780 |
AZD3229 |
AZD3229 is a potent, pan-Kit (c-Kit) mutant inhibitor with potent single digit nM growth inhibition against a diverse panel of mutant Kit (c-Kit) driven Ba/F3 cell lines (GI50=1-50 nM), with good margin to KDR-driven effects. It also inhibits PDGFR mutants (Tel-PDGFRα, Tel-PDGFRβ, V561D/D842V). |
| S7106 |
AZD3463 |
AZD3463 is a novel orally bioavailable ALK inhibitor with Ki of 0.75 nM, which also inhibits IGF1R with equivalent potency. AZD3463 suppresses cell viability by inducing both cell apoptosis and autophagy. |
| S7040 |
AZD3514 |
AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression.Phase 1. |
| S7731 |
AZD3839 |
AZD3839 is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.
|
| S7339 |
AZD3965 |
AZD3965 is a potent, selective and orally available monocarboxylate transporter 1 (MCT1) inhibitor with a binding affinity of 1.6 nM, 6-fold selective over MCT2. Phase 1. |
| E4741 |
AZD4144 |
AZD4144 (Compound 25) is a potent and selective inhibitor of the NLRP3 inflammasome with an IC50 of 76 nM in the nigericin-triggered speck formation assay. It binds directly to the NACHT domain of NLRP3, stabilizing its inactive conformation to prevent inflammasome activation. AZD4144 also inhibits LPS/ATP-induced release of pro-inflammatory cytokines IL-1β and IL-18 in mice with an IC50 of 54 nM and exhibits potential for treating inflammatory diseases. |
| S8719 |
AZD4573 |
AZD4573 is a potent inhibitor of CDK9 (IC50 of <0.004 μM) with fast-off binding kinetics (t1/2 = 16 min) and high selectivity versus other kinases, including other CDK family kinases. |
| S6645 |
AZD5069 |
AZD5069 is a novel antagonist of CXCR2, which is shown to inhibit binding of CXCL8 to CXCR2 with a pIC50 value of 8.8 and inhibit CXCL8 binding to CXCR1 with pIC50 values of 6.5. |
| S8344 |
AZD5153 6-hydroxy-2-naphthoic acid |
AZD5153 6-hydroxy-2-naphthoic acid (HNT salt) is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor with pKi of 8.3 for BRD4. AZD5153 inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes. NSD3, via H3K36me2, acts as an epigenetic deregulator to facilitate the expression of oncogenesis-promoting genes. |
| S2621 |
AZD5438 |
AZD5438 is a potent inhibitor of CDK1/2/9 with IC50 of 16 nM/6 nM/20 nM in cell-free assays. It is less potent to CDK5/6 and also inhibits GSK3β. |
| S8643 |
AZD5991 |
AZD5991 is a macrocyclic MCL-1 inhibitor with sub-nanomolar affinity for MCL-1 (Ki = 0.13 nM). The binding affinity of AZD5991 is about 25-fold lower for mouse Mcl-1 vs. human Mcl-1 but only four-fold lower for rat Mcl-1. |
| E0101 |
AZD6280 |
AZD6280 is a selective GABAA (α2/3) receptor modulator, used for treatment of generalized anxiety disorder. |
| S1462 |
AZD6482 |
AZD6482 (KIN-193) is a PI3Kβ inhibitor with IC50 of 10 nM, 8-, 87- and 109-fold more selective to PI3Kβ than PI3Kδ, PI3Kα and PI3Kγ in cell-free assays. Phase 1. |
| S0164 |
AZD7325 |
AZD7325 is a potent and orally active partial selective Positive allosteric modulator (PAM) of GABAAα2 and Aα3 receptor with Ki=0.3 and 1.3 nM, respectively, and has less antagonistic efficacy at the Aα1 and Aα5 receptor subtypes. |
| S3523 |
AZD7507 |
AZD7507 is a potent and orally active CSF-1R inhibitor, with antitumor activity. |
| S7517 |
AZD7545 |
AZD7545 is a potent PDHK inhibitor with IC50 of 36.8 nM and 6.4 nM for PDHK1 and PDHK2, respectively. It failed to inhibit PDHK4 at higher concentrations(>10 nM), AZD7545 stimulates PDHK4 activity. |
| S8843 |
AZD7648 |
AZD7648 is a potent inhibitor of DNA-PK with an IC50 of 0.6 nM in biochemical assay and more than 100-fold selective against 396 other kinases. |
| S1532 |
AZD7762 |
AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM in a cell-free assay. It is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. Phase 1. |
| S1555 |
AZD8055 |
AZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM in MDA-MB-468 cells with excellent selectivity (∼1,000-fold) against PI3K isoforms and ATM/DNA-PK. AZD8055 induces caspase-dependent apoptosis and also induces autophagy. Phase 1. |
| S7694 |
AZD8186 |
AZD8186 is a potent and selective inhibitor of PI3Kβ and PI3Kδ with IC50 of 4 nM and 12 nM, respectively. Phase 1.
|
| S2134 |
AZD8330 |
AZD8330 (ARRY704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1. |
| E1972 |
AZD8421 |
AZD8421 is a potent and highly selective inhibitor of Cyclin-dependent Kinase 2 (CDK2), with an IC50 against CDK2 of 9nM with selectivity over CDK1, CDK4 and CDK6. It also exhibits an anti-proliferative effect, effectively inhibits Rb phosphorylation, and shows strong activity both as a monotherapy and in combination with CDK4/6 inhibitors in breast and ovarian cancer models. |
| E1616 |
AZD8797( KAND567) |
AZD8797 (KAND567) is an allosteric, non-competitive, and orally active antagonist of the human receptor CX3CR1. It antagonizes CX3CR1 with a Ki value of 3.9 nM, respectively. It effects G-protein signaling and β-arrestin recruitment. |
| S7966 |
AZD8835 |
AZD8835 ia a novel mixed inhibitor of PI3Kα and PI3Kδ with IC50 of 6.2 nM and 5.7 nM, respectively, also with selectivity against PI3Kβ (IC50=431 nM) and PI3Kγ (IC50=90 nM). |
| S8372 |
AZD9496 |
AZD9496 is an oral estrogen receptor inhibitor that blocks the growth of ER-positive and ESR1 mutant breast tumours in preclinical models. |
| E2147 |
AZD9574 |
AZD9574 is a novel PARP inhibitor which combines PARP1 selectivity, trapping and high CNS penetration in a single molecule. |
| S4550 |
Azelaic acid |
Azelaic acid (Nonanedioic acid, Finacea, Azelex, Anchoic acid) is an organic compound produced by the ozonolysis of oleic acid and possesses antibacterial, keratolytic, comedolytic, and anti-oxidant activity. |
| E1928 |
Azelaprag |
|
| E4921 |
Azelastine |
Azelastine(Azelastina; Astelin) is a potent antihistaminic and antiallergic drug, an antagonist of the histamine H1 receptor. It is also effective in treating allergic rhinitis, bronchial asthma, and SARS-CoV-2 and has shown potential in ameliorating aortic calcification, increasing apoA expression, and reducing apoB levels. |
| S2552 |
Azelastine HCl |
Azelastine HCl is a potent, second-generation, selective, histamine receptor antagonist, used in the treatment of rhinitis. |
| S6415 |
Azeliragon (TTP488) |
Azeliragon (TTP488, PF-04494700) is an orally bioavailable small molecule that inhibits the receptor for advanced glycation endproducts (RAGE), which is an immunoglobulin-like cell surface receptor overexpressed in brain tissues of patients with AD. |
| S3053 |
Azelnidipine |
Azelnidipine (UR-12592) is a dihydropyridine calcium channel blocker. |
| S7454 |
Azemiglitazone (MSDC-0602) |
Azemiglitazone (MSDC-0602) is a direct mitochondrial pyruvate carrier (MPC) inhibitor that modulates central carbon metabolism in mice and humans.
|
| E1000 |
Azenosertib (Zn-C3) |
Azenosertib (Zn-C3) is an oral active, highly effective and selective Wee1 inhibitor with IC50 of 3.9 nM, which can be used in cancer research. |
| S5572 |
Azetidine-2-carboxylic acid |
Azetidine-2-carboxylic acid (L-Aze) is a toxic and teratogenic non-protein amino acid that is misincorporated into protein in place of proline, altering collagen, keratin, hemoglobin, and protein folding. |
| S0675 |
Azide-PEG5-Tos |
Azide-PEG5-Tos (Azido-PEG5-OTs) is a cleavable 5-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). |
| S3046 |
Azilsartan |
Azilsartan (TAK-536) is an angiotensin II type 1 (AT1) receptor antagonist with IC50 of 2.6 nM. |
| S3057 |
Azilsartan Medoxomil |
Azilsartan Medoxomil (TAK-491) is a potent angiotensin II type 1 (AT1) receptor antagonist, inhibits the RAAS, with an IC50 of 2.6 nM, exhibits >10,000-fold selectivity over AT2. |
| E7668 |
Azimilide |
Azimilide(NE-10064) is a class III antiarrhythmic compound, inhibits I(Ks) and I(Kr) in guinea-pig cardiac myocytes and I(Ks) (minK) channels expressed in Xenopus oocytes.IC50 value:Target: in vitro: Azimilide blocked HERG channels at 0.1 and 1 Hz with IC50s of 1.4 microM and 5.2 microM respectively. Azimilide blockade of HERG channels expressed in Xenopus oocytes and I(Kr) in mouse AT-1 cells was decreased under conditions of high [K+]e, whereas block of slowly activating I(Ks) channels was not affected by changes in [K+]e . Azimilide suppressed the following currents (Kd in parenthesis): IKr (< 1 microM at -20 mV), IKs (1.8 microM at +30 mV), L-type Ca current (17.8 microM at +10 mV), and Na current (19 microM at -40 mV). Azimilide was a |
| A3061 |
Azintuxizumab (Anti-SLAMF7 / CS1) |
Azintuxizumab (Anti-SLAMF7 / CS1/ CD319/ CRACC) is a monoclonal IgG4 bispecific antibody targeting B-cell maturation antigen (BCMA). It has the potential for the research of relapsed/refractory multiple myeloma (RRMM). MW :140.12 KD. |
| S1835 |
Azithromycin |
Azithromycin is an antibiotic by inhibiting protein synthesis, used for the treatment of bacterial infections. |
| S4147 |
Azithromycin Dihydrate |
Azithromycin Dihydrate(CP-62993 dihydrate) is an acid stable orally administered macrolide antimicrobial drug, structurally related to erythromycin. |
| S3195 |
Azlocillin sodium salt |
Azlocillin is an acylampicillin with a broad spectrum against bacteria. |
| S6033 |
Azo Rubine |
Azo Rubine is an synthetic red food dye and is used for the purposes where food is heat-treated after fermentation. |
| S2267 |
Azomycin |
Azomycin (2-Nitroimidazole) is an antimicrobial antibiotic produced by a strain of Nocardia mesenterica. |
| S8304 |
Azoramide |
Azoramide is a small-molecule modulator of the unfolded protein response (UPR). It improves ER protein-folding ability and activates ER chaperone capacity to protect cells against ER stress.
|
| E2358 |
Azosemide |
Azosemide is a potent Na+–K+–2Cl− cotransporter NKCC1 inhibitor with IC50s of 0.246 µM for hNKCC1A and 0.197 µM for NKCC1B, respectively. |
| E7850 |
AZP-531 |
AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight. |
| S1505 |
Aztreonam |
Aztreonam (SQ 26776) is a synthetic monocyclic beta-lactam antibiotic, used to treat Gram-negative aerobic bacteria infection. |
| S3191 |
Azumolene |
Azumolene (EU4093 free base), an equipotent dantrolene analog, is a ryanodine receptor (RyR) modulator that inhibits the calcium-release. |
| E1243 |
Azvudine |
Azvudine (RO-0622) is a novel nucleoside reverse transcriptase inhibitor with antiviral activity against human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV), potently inhibits HIV-1 (EC50 range 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM). |
| F0616 |
α Actinin (C22H3) Rabbit mAb |
Actinin alpha,alpha Actinin/ACTN1,alpha-Actinin,α-Actinin |
| F2199 |
α Actinin 1/ACTN1 (C8H2) Rabbit mAb |
Actinin alpha,alpha Actinin/ACTN1,alpha-Actinin,α-Actinin |
| F2033 |
α Actinin 4 Rabbit mAb |
alpha Actinin 4,α-Actinin 4 |
| F0821 |
α-Amylase Rabbit mAb |
alpha-Amylase,Amylase,α-Amylase |
| E7416 |
α-Amyrin |
α-Amyrin is a pentacyclic triterpenoid compound with oral activity. α-Amyrin activates the ERK and GSK-3β signaling pathways. α-Amyrin can be used in the study of metabolic syndrome induced by high fructose diet and cognitive dysfunction caused by low cholinergic neurotransmission. |
| F1147 |
β Arrestin 1 Rabbit mAb |
beta Arrestin 1,β-Arrestin 1 |
| F0012 |
β-Actin Rabbit mAb |
ACTB,beta Actin,beta Actin Loading Control,beta-Actin,β-Actin |
| S5526 |
β-Alanine |
β-Alanine (beta-Alanine, 3-Aminopropanoic acid) is a naturally occurring beta amino acid formed in vivo by the degradation of dihydrouracil and carnosine. It acts as a neurotransmitter by activating glycine and GABA receptors. |
| S6219 |
β-Alanine methyl ester hydrochloride |
β-Alanine ethyl ester is the ethyl ester of the non-essential amino acid β-alanine. |
| E4275 |
β-Aminopropionitrile |
β-Aminopropionitrile (BAPN) is an orally active, specific, and irreversible inhibitor of lysyl oxidase (LOX). It targets the active site of LOX or LOXL isoenzymes. |
| E7047 |
β-Amyloid (1-40) |
β-Amyloid (1-40) is a primary protein in plaques found in the brains of patients with Alzheimer's disease. |
| E8016 |
β-Amyloid (1-40) (rat) |
β-Amyloid (1-40) (rat) is a rat form of the amyloid β-peptide, which accumulates as an insoluble extracellular deposit around neurons, giving rise to the senile plaques associated with Alzheimer's disease (AD). β-Amyloid (1-40) (rat) increases 45Ca2+ influx, induces neurodegeneration in the rat hippocampal neurons of the CA1 subfield. β-Amyloid (1-40) (rat) induces apoptosis. β-Amyloid (1-40) (rat) can be used for the research of Alzheimer's disease. |
| P1003 |
β-Amyloid (1-42), human |
β-Amyloid (1-42), human is a peptide fragment composed of 42 amino acids, derived from amyloid precursor protein (APP), and plays a crucial role in Alzheimer's disease (AD). It self-aggregates into oligomers and fibrils, with the oligomeric form being the most neurotoxic. These aggregates form amyloid plaques, a characteristic feature of AD, which interfere with cellular functions, cause mitochondrial dysfunction, and lead to neuronal cell death through oxidative stress, calcium dysregulation, and inflammation. |
| E2948 |
β-Amyloid (25-35) |
β-Amyloid (25-35) (Amyloid beta-peptide (25-35), Aβ25-35, β-Amyloid peptide (25-35)) , a sequence GSNKGAIIGLM, is a highly toxic synthetic derivative of Amyloid beta-peptide (Aβ-peptides) which forms fibrillary aggregates. β-Amyloid (25-35) is involved in the pathogenesis of Alzheimer's disease. |
| E0246 |
β-Anhydroicaritin |
β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has antiosteoporosis, estrogen regulation and antitumor properties. |
| F0617 |
β-Arrestin 1/2 Rabbit mAb |
β-arrestin-1, beta-arrestin-1, Arrestin beta-1, Non-visual arrestin-2, ARRB1, ARR1, β-arrestin-2, Beta-arrestin-2, Arrestin beta-2, Non-visual arrestin-3, ARRB2, ARB2, ARR2 |
| F0667 |
β-Arrestin 2 Rabbit mAb |
Beta Arrestin 2,β-Arrestin 2,β-Arrestin-2 |
| F1057 |
β2 Adrenergic Receptor Rabbit mAb |
beta 2 Adrenergic Receptor,β2-Adrenergic Receptor |
| F2446 |
γ Actin Rabbit mAb |
gamma Actin,gamma-Actin |