所有产品

目录号	产品名	产品描述
S6475	Polaprezinc	Polaprezinc (Aprozinate, Carnosine zinc complex, Zinc L-carnosine) is an orally bioavailable chelate composed of zinc and L-carnosine, with potential gastroprotective, anti-oxidant, anti-ulcer and anti-inflammatory activities.
S9388	(+)-Praeruptorin A	Praeruptorin A is a coumarin compound naturally occurring in the roots of Peucedanum praeruptorum Dunn., a commonly used traditional Chinese medicine for the treatment of certain respiratory diseases and hypertension. Praeruptorin A exerts anti-inflammatory effects in vitro through inhibition of NF-κB activation. (+)-Praeruptorin A is one of enantiomers.
S7383	(-)-p-Bromotetramisole Oxalate	(-)-p-Bromotetramisole Oxalate (L-p-Bromotetramisole Oxalate) is a potent and non-specific alkaline phosphatase inhibitor.
S2341	(-)-Parthenolide	(-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, specifically depletes HDAC1 protein without affecting other class I/II HDACs; Also promotes the ubiquitination of MDM2 and activates p53 cellular functions.
S6275	(−)-β-Pinene	(−)-β-Pinene (Nopinene) is a natural organic compound in various plants. It is lethal to S. littoralis third instar larvae (LD50 = 65 μg/larva), inhibits infectious bronchitis virus (IBV) replication (IC50 = 1.32 mM) and exhibits a cytotoxic concentration (CC50) value of greater than 10 mM in Vero cells.
S5543	1, 10-Phenanthroline monohydrate	1,10-Phenanthroline is a classic chelating bidentate ligand for transition metal ions that has played an important role in the development of coordination chemistry. It is an inhibitor of metallopeptidases.
S6258	1,2-Propanediol	1,2-Propanediol (1,2-Dihydroxypropane, Propylene glycol, Methyl ethyl glycol) is a synthetic liquid substance that is commonly used as an excipient in a variety of drugs and it is also authorised in food products and cosmetics.
E8236	1,5-pentanediol-d10	1,5-pentanediol-d10 is the deuterated form of 1,5-pentanediol. 1,5-Pentanediol is an organic diol.
E7140	1-Palmitoyl-2-oleoyl-sn-glycero-3-PC	1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC), a phospholipid, is a major component of biological membranes. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC is used for the preparation of liposomes and studying the properties of lipid bilayers.
E7390	1-Palmitoyl-sn-glycero-3-phosphocholine	1-Palmitoyl-sn-glycero-3-phosphocholine is an abundant lysophosphatidylcholine. 1-Palmitoyl-sn-glycero-3-phosphocholine exhibits proinflammatory activity. 1-Palmitoyl-sn-glycero-3-phosphocholine can be used in the study of atherosclerosis.
S6009	1-Phenyl-1,2-propanedione	1-Phenyl-1,2-propanedione (Acetyl benzoyl) is an eukaryotic metabolite produced during a metabolic reaction in plants.
E2908	1-PHENYL-2-THIOUREA	1-PHENYL-2-THIOUREA(N-Phenylthiourea, PTU, Phenylthiocarbamide) is an inhibitor of tyrosinase (Tyr). 1-PHENYL-2-THIOUREA blocks pigmentation and improves optical transparency in zebrafish (Danio rerio) embryo.
S2578	1-Phenylbiguanide	1-Phenylbiguanide (Phenylbiguanide, PBG, N-Phenylbiguanide) is a 5-hydroxytryptamine3 (5-HT3) receptor agonist with EC50 of 3.0 μM.
F2658	14-3-3 (pan) Antibody [N16K10]	14-3-3 (pan),pan 14-3-3
S5906	2,4-Pyridinedicarboxylic acid	2,4-Pyridinedicarboxylic acid (Lutidinic Acid, 2,4-Dicarboxypyridine, 2,4-PDCA) is a compound that structurally mimics 2-oxoglutarate (2-OG) and chelates zinc, thus affecting a range of enzymes. It blocks the activity of 2-OG oxygenases.
E7052	2-(Pyridyldithio)ethylamine hydrochloride	2-(Pyridyldithio)ethylamine hydrochloride is a novel disulfide intercalating cross-linking reagent.
S9334	2-Pentylfuran	2-Pentylfuran (2-Amylfuran) is a naturally occuring flavouring ingredient.
S4440	2-Phenylacetamide	2-Phenylacetamide, the main compound isolated from the seeds of Lepidium apetalum Willd (LA) with estrogenic activities, increases the expression of Estrogen receptorα (ERα), ERβ and GPR30 in the uterus and MCF-7 cells.
S5347	2-Phenylethylamine	2-Phenylethylamine (β-Phenylethylamine, benzeneethanamine, β-aminoethylbenzene) is a natural monoamine alkaloid that functions as a monoaminergic neuromodulator or a neurotransmitter in the human central nervous system.,
S5346	2-Phenylethylamine hydrochloride	2-Phenylethylamine hydrochloride (β-Phenylethylamine, benzeneethanamine, β-aminoethylbenzene) is the hydrochloride salt form of 2-Phenylethylamine, which is an aromatic amine acting as a monoaminergic neuromodulator or a neurotransmitter in the human central nervous system.
S5877	2-Phenylimidazole	2-phenylimidazole (PhI, 2-Phenyl-1H-imidazole) is a corrosion inhibitor for brass and can be used to prepare complex compounds with ruthenium(III).
S6321	2-Phenylpropionic acid	2-Phenylpropionic acid (2-Phenylpropionate, Hydratropic acid, α-methyl-α-toluic acid) is an intermediate in alpha-Methylstyrene (2-phenylpropylene) metabolism.
S6317	2-Picolinic acid methyl ester	2-Picolinic acid methyl ester (Methyl picolinate, 2-Pyridinecarboxylic acid methyl ester, Methyl pyridine-2-carboxylate) is used as pharmaceutical intermediate.
E7029	2-PMPA	2-PMPA is a potent and selective inhibitor of glutamate carboxypeptidase II (GCPII) with an IC50 of 300 pM.
S3597	3-Phenoxybenzoic acid	3-phenoxybenzoic acid (3-PBA), an intermediate metabolite of pyrethroids, is more toxic than its parent compounds and has been detected in milk, soil, and human urine.
S7639	3PO	3PO (3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one) is a small-molecule inhibitor of PFKFB3 with an IC50 of 22.9 μM for recombinant human PFKFB3 protein and does not inhibit PFK-1 activity. It suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.
E7113	4-P-PDOT	4-P-PDOT is a potent, selective and affinity Melatonin receptor (MT2) antagonist. 4-P-PDOT is >300-fold more selective for MT2 than MT1. 4-P-PDOT significantly counteracts Melatonin-mediated antioxidant effects (GSH/GSSG ratio, phospho-ERK, Nrf2 nuclear translocation, Nrf2 DNA-binding activity).
S3592	4-PBA (4-Phenylbutyric acid)	4-PBA (4-Phenylbutyric acid) is a histone deacetylase (HDAC) inhibitor and a key epigenetic inducer of anti-HCV hepatic hepcidin. 4-Phenylbutyric acid inhibits LPS-induced inflammation through regulating endoplasmic-reticulum (ER) stress and autophagy in acute lung injury models.
S4125	4-PBA (Sodium Phenylbutyrate)	4-PBA (Sodium Phenylbutyrate) is a salt of 4-phenylbutyrate (4-PBA) or 4-phenylbutyric acid.Sodium phenylbutyrate is a histone deacetylase inhibitor, used to treat urea cycle disorders.
S6268	4-Pentenoic acid	4-Pentenoic acid (Allylacetic acid, 3-vinylpropionic acid, 4-penten-1-oic acid), a flavouring ingredient, is used to inhibit fatty acid oxidation in rat heart mitochondria.
E7734	5-Pentadecylresorcinol	5-Pentadecylresorcinol (Adipostatin A) is a glycerol-3-phosphate dehydrogenase (GPDH) inhibitor with an IC50 of 4.1 µM. Adipostatin A shows good larvicidal activity against Aedes aegypti.
E8177	5-Ph-IAA	The 5-Ph-IAA is a bumped-IAA analogue, that establishes the auxin-inducible degron 2 (AID2) system with the OsTIR1(F74G) mutant, enabling precise, rapid degradation with 670-fold lower ligand concentration. It induces rapid and efficient depletion of mAID-fused proteins to study protein function in living cells, exhibiting significant tumor suppression properties.
S3978	5-Phenyl-2,4-pentadienoic acid	5-Phenyl-2,4-pentadienoic acid (5-Phenylpenta-2,4-dienoic acid) is used as Synthetic building block, anti-malarial agent.
S6096	5-Phenylvaleric Acid	5-Phenylvaleric acid (Benzenepentanoic acid, Phenylpentanoic acid, Phenylvaleric Acid) is a Pentanoic acid of bacterial origin, occasionally found in human biofluids.
S5551	6-Paradol	6-Paradol is a minor constituent of ginger, mainly formed from 6-gingerol via 6-shogaol, and exhibits a variety of biological activities including anti-cancer, anti-inflammatory, and anti-oxidative activities. Paradol is an inhibitor of cyclooxygenase (COX)-2.
E0028	9-Phenanthrol	9-Phenanthrol (9-Hydroxyphenanthrene, Phenanthren-9-o, 9-Phenanthrenol) is a selective TRPM4 inhibitor with an IC50 in the range of 0.02 μM, without effects on TRPM5.
F1045	P Glycoprotein Antibody [C5K22]	CD243 (MDR-1),MDR1,MDR1/ABCB1,P Glycoprotein,P-Glycoprotein,P-Glycoprotein (MDR)
E8135	P-1075	P-1075 is a potent activator of sulfonylurea receptor 2-associated ATP-sensitive potassium channels (SUR2-KIR6), with an EC50 value of 45 nM for SUR2B-KIR6 channel activation. P-1075 also P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts.
S5086	p-Anisaldehyde	p-Anisaldehyde (4-Methoxybenzaldehyde, Anisaldehyde, Anisic aldehyde, P-Methoxybenzaldehyde, 4-Anisaldehyde), an extract from Pimpinella anisum seeds, exhibits antifungal activity against a number of yeast and mold strains in laboratory media, fruit purees and fruit juices.
S4759	p-Coumaric Acid	p-Coumaric acid (4-Hydroxycinnamic acid, P-Hydroxycinnamic acid, 4-Coumaric acid, Trans-p-Coumaric acid, para-Coumaric Acid) is a hydroxy derivative of cinnamic acid found in a variety of edible plants and is reported to have antioxidant, anti-inflammatory, and antimicrobial activity.
E7497	p-Cresyl sulfate potassium	p-Cresyl sulfate potassium is a uremic toxin that binds to a prototype protein. p-Cresyl sulfate potassium activates the JNK and p38 MAPK signaling pathways. p-Cresyl sulfate potassium has pro-inflammatory activity.
S9564	p-Hydroxy-cinnamic Acid	p-Hydroxy-cinnamic Acid has in vitro antimalarial activity and in vivo anti-osteoporotic properties.
S6008	p-Hydroxybenzaldehyde	p-Hydroxybenzaldehyde (4-Hydroxybenzaldehyde, 4-Formylphenol, p-Formylphenol), which can be found in the orchids Gastrodia elata, Galeola faberi and vanilla, is a hydroxybenzaldehyde that reacts with NAD+ and H2O to produce 4-hydroxybenzoate, NADH, and 2 protons. p-Hydroxybenzaldehyde at 101.7 μM can significantly reduce the GABA-induced chloride current of GABAA receptors(α1β2γ2S subtype) expressed.
E1248	p-Nitrobenzyl mesylate	p-Nitrobenzyl mesylate is an alkylating reagent for direct kinase substrate identification.
S6188	p-Toluenesulfonic acid monohydrate	p-Toluenesulfonic acid (4-Methylbenzenesulfonic acid, Tosylic acid, tosic acid, para-toluene) is an extremely strong acidic compound.
E4074	p-Toluic acid	p-Toluic acid (4-Methylbenzoic acid) is a methylbenzoic acid and can be used as an intermediate for the synthesis of para-aminomethylbenzoic acid (PAMBA), p-tolunitrile, etc. It also exhibits hepatotoxicological potential in humanised-liver mice.
S9887	P110	P110 is a dynamin-related protein 1 (Drp1)-specific inhibitor that binds directly to Drp1.
S8917	P110δ-IN-1	P110δ-IN-1 is an oral, potent and selective inhibitor of Phosphatidylinositol 3-Kinase (PI3K) P110δ with IC50 of 0.6 nM in cellular assay.
F1416	p115 RhoGEF Antibody [P4K2]
A5168	p120 (Catenin Delta 1) Rabbit Recombinant mAb	p120 (Catenin Delta 1) Rabbit Recombinant mAb detects endogenous level of total p120 (Catenin Delta 1).
F0867	p130 Cas Antibody [P2F10]	BCAR1,p130 Cas
F0536	p14 ARF Antibody [J3P11]	CDKN2A/p14ARF,p14 ARF,p14ARF,p14ARF/CDKN2A
A5869	p16 INK Rabbit Recombinant mAb	p16 INK Rabbit Recombinant mAb detects endogenous levels of total p16 INK.
F1058	p18 INK4c/CDKN2C Antibody [G16B6]	p18 INK4C,p18 INK4c/CDKN2C
A5163	p21 Rabbit Recombinant mAb	p21 Rabbit Recombinant mAb detects endogenous levels of total p21.
F0170	p21 Waf1/Cip1 Antibody [F7M18]	p21,p21 Waf1/Cip1,p21/CIP1/CDKN1A,p21/WAF1/Cip1,Waf1/Cip1/CDKN1A p21
A5407	p23 Rabbit Recombinant mAb	p23 Rabbit Recombinant mAb detects endogenous level of total p23.
F2538	p27 KIP 1 Antibody [A16H11]	CDKN1B/Kip1 p27,p27,p27 KIP 1,p27 Kip1,p27[Kip1]
F1511	P2X7 Receptor Antibody [L17L11]	P2X7,P2X7 Receptor
F0460	p35/25 Antibody [H17P2]
F0171	p38 MAPK Antibody [N23C2]	Mitogen-activated protein kinase 14, MAP kinase 14; MAPK 14, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP, MAP kinase MXI2, MAX-interacting protein 2,MAP kinase p38 alpha, MAP kinase p38 α, SAPK2a, MAP kinase 12; MAPK 12, ERK-6, ERK6, MAP kinase p38 gamma, MAPK12, SAPK3, MAP kinase 11; MAPK 11, MAP kinase p38 beta, p38b, SAPK2b, p38-2, MAPK11, PRKM11, SAPK2, SAPK2B, CSBP, CSBP1, CSBP2, MXI2, MAP kinase p38 γ,MAP kinase p38 gamma, Stress-activated protein kinase 3, MAP kinase p38 β, MAP kinase p38 beta, p38b
E2372	p38-α MAPK-IN-1	p38-α MAPK-IN-1 is an inhibitor of p38-α, with IC50 value of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay.
F4658	p38α MAPK Antibody [N19P8]
F1221	p38α/MAPK14 Antibody [J11A5]	Mitogen-activated protein kinase 14, MAP kinase 14; MAPK 14, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP MAP kinase MXI2, MAX-interacting protein 2,Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Mitogen-activated protein kinase p38 α, MAP kinase p38 α, Stress-activated protein kinase 2a, MAP kinase p38 alpha, SAPK2a, CSBP1, CSBP2, MXI2, Mitogen-activated protein kinase 11, Mitogen-activated protein kinase p38 beta, Mitogen-activated protein kinase p38 β, MAP kinase p38 beta, p38b, MAP kinase p38 β, Stress-activated protein kinase 2b, SAPK2b, p38-2, PRKM11, SAPK2, SAPK2B
F1367	p38δ MAPK Antibody [C13H14]	p38 delta/MAPK13,p38δ MAPK
F3509	p44/42 MAPK (Erk1/2) Antibody [E11P7]	ERK 1/2,ERK1 + ERK2,Erk1/2 (p44/p42),ERK1/ERK2,MAP Kinase (ERK-1, ERK-2),MAP Kinase, Non-Phosphorylated ERK,p44/42 MAPK (Erk1/2)
F0002	p44/42 MAPK (Erk1/2) Antibody [F1E12]	Mitogen-activated protein kinase 3, MAP kinase 3, MAPK 3, ERT2, Extracellular signal-regulated kinase 1, ERK-1, ERK1, Insulin-stimulated MAP2 kinase, MAP kinase isoform p44, p44-MAPK, Microtubule-associated protein 2 kinase, p44-ERK1, PRKM3, Mitogen-activated protein kinase 1, MAP kinase 1, MAPK 1, ERT1, Extracellular signal-regulated kinase 2, ERK-2, MAP kinase isoform p42, p42-MAPK, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2,ERK2, PRKM1, PRKM2
F1466	p47phox Antibody [E24P19]	NCF1/p47-phox,p47phox
S7132	P5091	P5091 is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM and the closely related USP47.
F2018	p53 (acetyl Lys 370) Antibody [L18F8]
F0020	p53 Antibody [F16A10]	p53,p53 (pantropic),TP53
A5268	p57 Kip2 Rabbit Recombinant mAb	p57 Kip2 Rabbit Recombinant mAb detects endogenous level of total p57 Kip2.
F1401	p58IPK Antibody [M17H14]
F3974	p60 CAF1/MPP7 Antibody [J6B14]
E1462	P62-mediated mitophagy inducer	P62-mediated mitophagy inducer (PMI) is a P62-mediated activator of mitophagy that functions independently of parkin recruitment or mitochondrial membrane potential (ΔΨm) collapse. It remains effective even in cells lacking a fully functional PINK1/Parkin pathway. PMI stabilizes Nrf2 and enhances p62 expression, thereby activating mitophagy.
F1148	p63 Antibody [C16H5]
F0767	p63-α Antibody [F10N6]
F3527	p70 S6 Kinase Antibody [B15P21]	p70 S6 Kinase,p70 S6 kinase α,p70 S6 kinase/S6K1,S6K1
F0011	p70 S6 Kinase Antibody [D7E4]	p70 S6 Kinase,p70 S6 kinase α,p70 S6 kinase/S6K1,S6K1
F2933	P70 S6 Kinase beta/SRK-N-terminal Antibody [G11B4]	p70 S6 Kinase 2,P70 S6 Kinase beta/SRK,Phospho-(Ser/Thr) PKA Substrate,RPS6KB2
F1059	p73 Antibody [F14N9]
F0563	p75NTR Antibody [K22C18]	CD271,Nerve Growth Factor Receptor,NGFR p75,p75 LNGFR,p75 NGF Receptor,p75NTR
S7968	P7C3	P7C3 is a potent proneurogenic and neuroprotective chemical that targets NAMPT enzyme.
S0287	P7C3-A20	P7C3-A20 is a highly active analogue of P7C3. P7C3-A20 is neuroprotective and promotes endogenous reparative strategies after TBI (Traumatic brain injury).
F0868	p95/NBS1 Antibody [B19M8]	Nbs1,p95/NBS1
F1648	PABP1 Antibody [H6J19]	PABP, PABP1
F2193	PABPN1 Antibody [G24K9]	PABP2,PABPN1
S2738	PAC-1	PAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM and the first small molecule known to directly activate procaspase-3 to caspase-3.
S8415	PACAP 1-38	PACAP 1-38 (Pituitary Adenylate Cyclase Activating Polypeptide 38) is a highly potent PACAP receptor agonist (Kd = 100 pM). It stimulates adenylate cyclase and phagocytosis.
S8416	PACAP 6-38 acetate	PACAP 6-38 acetate is a PACAP (pituitary adenylate cyclase-activating polypeptide) non-stimulating competitive antagonist with an IC50 value of 2 nM. It also acts as a functional CARTp antagonist in vivo.
E0214	Pachymic acid	Pachymic acid(3-O-Acetyltumulosic acid) inhibits the activity of CYP2C9 with the IC50 of 21.25 µM.
S1150	Paclitaxel	Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy.
S8057	Pacritinib	Pacritinib is a potent and selective inhibitor of Janus Kinase 2 (JAK2) and Fms-Like Tyrosine Kinase-3 (FLT3) with IC50s of 23 and 22 nM in cell-free assays, respectively. Phase 3.
F2996	PACT (PKR activating protein) / PRKRA Antibody [F4M5]	PACT,PACT (PKR activating protein) / PRKRA
F2103	PADI4/PAD4 Antibody [B6N23]
S8444	Padnarsertib (KPT 9274)	Padnarsertib (KPT 9274) is an orally bioavailable small molecule that is a non-competitive dual inhibitor of PAK4 and NAMPT. It shows an IC50 of ~120 nM for NAMPT in a cell-free enzymatic assay.
E0752	Paederoside	Paederoside is a monoterpene S-methyl thiocarbonate isolated from Paederia pertomentosa and inhibits Epstein-Barr virus (EBV) early antigen (EA).
E3092	Paeoniae Radix Rubra Extract	Paeoniae Radix Rubra Extract is obtained from Paeoniae Radix Rubra, prevents deep vein thrombosis by ameliorating inflammation through inhibiting GSK3β activity.
E3491	Paeonia suffruticosa root bark Extract	Paeonia Suffruticosa Root Bark Extract is extracted from the root bark of Paeonia suffruticosa, which exhibits potential anti-inflammatory properties through an increase in antioxidant activity.
S2410	Paeoniflorin (NSC 178886)	Paeoniflorin (NSC 178886,Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall. Paeoniflorin reduces COX-2 expression. Paeoniflorin alleviates liver fibrosis by inhibiting HIF-1α through mTOR-dependent pathway.
S2339	Paeonol	Paeonol (Peonol), a phenolic compound extracted from Chinese herbs Paeonia suffruticosa (moutan cortex) and Cynanchum paniculatum, inhibits MAO with an IC50 of about 50 μM.
E7380	Pafuramidine	Pafuramidine (DB289) is an orally active proagent of Furamidine (HY-110137A). Pafuramidine is a potent anti-parasitic agent, can be used to research trypanosomiasis, Pneumocystis pneumonia and malaria.
F0743	PAI-1 Antibody [J4H7]	PAI1,PAI-1,PAI-1/SERPINE1,Serpin E1/PAI-1
F3786	PAI1 Antibody [E17P19]	PAI1,PAI-1,PAI-1/SERPINE1,Serpin E1/PAI-1
F3217	PAK1 Antibody [P10N18]
F1046	PAK2 Antibody [N15H3]	Serine/threonine-protein kinase PAK 2, Gamma-PAK, PAK65, S6/H4 kinase, p21-activated kinase 2 , PAK-2, p58, PAK2, Serine/threonine-protein kinase PAK 3, Beta-PAK Oligophrenin-3, p21-activated kinase 3, PAK-3, PAK3, OPHN3, Serine/threonine-protein kinase PAK 1, Alpha-PAK,α-PAK, p21-activated kinase 1, PAK-1, p65-PAK
E1842	Palazestrant	Palazestrant(OP-1250) is an orally bioavailable complete antagonist of estrogen receptor (ER) that blocks ER activity. It exhibits antiproliferative and antitumor activity in ER-positive (ER⁺) breast cancer models.
S4482	Palbociclib (PD-0332991)	Palbociclib (PD 0332991) is a highly specific inhibitor of cyclin-dependent kinase 4 (Cdk4) and Cdk6 with IC50 of 11 nM and 16 nM, respectively.This product has poor solubility, animal in vivo experiments are available, cell experiments please choose carefully!
S1116	Palbociclib (PD-0332991) Hydrochloride	Palbociclib (PD-0332991) HCl is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays, respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3.
S1579	Palbociclib (PD-0332991) Isethionate	Palbociclib Isethionate is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3.
E6025	Palbociclib 2HCL	Palbociclib 2HCL (PD-0332991 dihydrochloride), the dihydrochloride salt of Palbociclib, is a highly specific inhibitor of Cdk4 and Cdk6, with IC50 values of 11 nM and 16 nM, respectively. It is a potent antiproliferative agent against retinoblastoma (Rb)-positive tumor cells in vitro, inducing a selective G1 cell cycle arrest and reducing phosphorylation at Ser780 and Ser795 on the Rb protein.
S5840	Palifosfamide	Palifosfamide (ZIO-201, Isophosphamide mustard) is a novel DNA alkylator and the active metabolite of ifosfamide with potential antineoplastic activity.
S1724	Paliperidone	Paliperidone, the main active metabolite of Risperidone, is a potent serotonin-2A and dopamine-2 receptor antagonist, used in the treatment of schizophrenia.
S5624	Paliperidone Palmitate	Paliperidone Palmitate (9-hydroxyrisperidone palmitate) is a palmitate ester of paliperidone, which is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class.
F4554	Palladin Antibody [M23E22]
S3769	Palmatine	Palmatine (Berbericinine, Burasaine), an isoquinoline alkaloid, has sedative, antidepressant, antioxidative, anti-ulcerative, antacid, anticancer, and anti-metastatic activities.
S2397	Palmatine chloride	Palmatine hydrochloride (Palmatine chloride (6CI,7CI); Fibrauretin) is a hydrochloride salt of palmatine which is a protoberberine alkaloid.
E7726	Palmitelaidic Acid	Palmitelaidic Acid (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.
S3794	Palmitic acid	Palmitic acid (Hexadecanoic acid, Cetylic acid) is the most common saturated fatty acid found in animals, plants and microorganisms with anti-tumor activity. This product is a fatty acid that is almost insoluble in water-soluble solvents such as culture medium. It needs to be emulsified before use in cell experiments. It is recommended to purchase it in powder form.
S3341	Palmitoleic acid	Palmitoleic acid (POA, Palmitoleate) stimulates the uptake of glucose in liver through activation of AMPK and FGF-21, dependent on PPARα.
S4708	Palmitoylethanolamide	Palmitoylethanolamide (PEA, Palmidrol, N-palmitoylethanolamine) is an endogenous fatty acid amide and selectively activates PPAR-α in vitro with an EC50 value of 3.1±0.4 μM.
S2238	Palomid 529 (P529)	Palomid 529 (P529, SG 00529) inhibits both the mTORC1 and mTORC2 complexes, reduces phosphorylation of pAktS473, pGSK3βS9, and pS6. Phase 1.
S5740	Palonosetron	Palonosetron (RS25259, RS 25259 197) is a 5-HT3 antagonist with Ki value of 0.17 nM. It is used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).
S3050	Palonosetron HCl	Palonosetron HCl (RS 25259, RS 25259 197) is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.
E7522	Palosuran	Palosuran (ACT-058362) is a potent, selective, and orally active antagonist of urotensin II receptor, with an IC50 of 3.6 nM for CHO cell membranes expressing human recombinant receptors. Palosuran can improves pancreatic and renal function in diabetic rats.
E1445	Palovarotene	Palovarotene (R 667; Ro 3300074) is a nuclear retinoic acid receptor γ (RAR-γ) agonist. It reduces heterotopic ossification (HO) in cultures and in murine and rat fibrodysplasia ossificans progressiva (FOP) models.
E2406	Paltusotine	Paltusotine (CRN00808) is an orally active, nonpeptide selective somatostatin type 2 (SST2) receptor agonist, has the potential for maintaining GH and IGF-1 levels after depot somatostatin receptor ligand therapy.
E7472	Pam3CSK4	Pam3CSK4 (Pam3Cys-Ser-(Lys)4) is a synthetic triacylated lipopeptide that serves as a ligand for the Toll-like receptor 2/1 (TLR2/1) heterodimer. It is an agonist of toll-like receptor 1/2 (TLR1/2) with an EC50 of 0.47 ng/mL in human TLR1/2.
S5555	Pamabrom	Pamabrom is a diuretic agent.
S8125	Pamapimod	Pamapimod (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase. It inhibits p38α and p38β enzymatic activity with IC50 values of 0.014±0.002 and 0.48± 0.04 microM, respectively with no activity against p38delta or p38gamma isoforms.
S0821	Pamicogrel	Pamicogrel (KBT3022) is an inhibitor of cyclooxygenase (COX) with platelet anti-aggregatory properties.
S1311	Pamidronate Disodium	Pamidronate Disodium (CGP 23339AE) is a nitrogen containing bisphosphonate, used to prevent osteoporosis.Pamidronate Disodium is a inhibitor of bone resorption factor.
E6057	Pamidronate disodium pentahydrate	Pamidronate disodium pentahydrate is a nitrogen-containing bisphosphonate and used to prevent bone loss due to steroid use like glucocorticoid-induced low bone mineral density in children or to inhibit calcium release from bone by impairing osteoclast-mediated bone resorption. It also inhibits the Wnt/β-catenin signaling pathway that controls osteogenic differentiation in bone marrow mesenchymal stem cells (BMMSCs).
S8592	Pamiparib	Pamiparib is a potent and selective inhibitor of PARP1 and PARP2 with IC50 values of 0.83 and 0.11 nM, respectively in biochemical assays. It shows high selectivity over other PARP enzymes.
E2660	Pamoic acid disodium	Pamoic acid disodium, a potent GPR35 agonist with an EC50 value of 79 nM, induces GPR35a internalization and activates ERK1/2 with EC50 values of 22 nM and 65 nM, respectively, also potently recruits β-arrestin2 to GPR35 showing an antinociceptive effect.
A2042	Pamrevlumab (anti-CTGF)	Pamrevlumab, a recombinant human antibody that binds to connective tissue growth factor (CTGF) has emerged as a potential therapy for idiopathic pulmonary fibrosis (IPF).
S6764	Pamufetinib (TAS-115)	Pamufetinib (TAS-115) is a highly potent c-Met and VEGFR dual inhibitor with IC50s of 30 nM and 32 nM for recombinant VEGFR2 and recombinant MET, respectively.
F0771	Pan Cadherin Antibody [M17C10]	Cadherin-2, CDw325, Neural cadherin, N-cadherin, CD325, CDH2, CDHN, NCAD, Cadherin-3, Placental cadherin, P-cadherin, CDH3, CDHP, Cadherin-1, CAM 120/80, Epithelial cadherin, E-cadherin, CD324, CDH1, CDHE, UVO, Cadherin-5, 7B4 antigen, Vascular endothelial cadherin, VE-cadherin, CD144, CDH5, Cadherin-4, Retinal cadherin, R-CAD, R-cadherin, CDH4
F3760	PAN TEAD Antibody [A12P9]	Pan-TEAD,TEAD4/TEF-1
F1138	Pan Trk Antibody [B9H18]	High affinity nerve growth factor receptor,Neurotrophic tyrosine kinase receptor type 1, TRK1-transforming tyrosine kinase protein, Tropomyosin-related kinase A Tyrosine kinase receptor, Trk-A, NTRK1, MTC, TRK, TRKA, NT-3 growth factor receptor, Trk-C, Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, NTRK3, TRKC, BDNF/NT-3 growth factors receptor, Trk-B, Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, Tropomyosin-related kinase B
E1157	Pan-RAS-IN-1	Pan-RAS-IN-1, a pan-Ras inhibitor, binds to KRas^G12D-GppNHp with a Kd less than 20 μM in MST, ITC and NMR assays, also binds to Ras proteins and exhibits lethality in cells partially dependent on expression of Ras proteins.
F0747	Pan-TEAD Antibody [L14N23]	Transcriptional enhancer factor TEF-4, TEA domain family member 2, Transcriptional enhancer factor TEF-1, TEAD-2, TEAD2, TEF4, TEF-4, TEF-1, TEF1, NTEF-1, Protein GT-IIC, TEA domain family member 1, TEAD-1, TEAD1, Transcription factor 13, TCF-13, TCF13, TEAD-4, TEAD4, RTEF-1, RTEF1, TCF13L1, TEF3, TEF-3, TEF-5, TEF5, DTEF-1, DTEF1, TEAD-3, TEAD3, Transcriptional enhancer factor TEF-3, TEA domain family member 4, Transcription factor 13-like 1, Transcription factor RTEF-1, Transcriptional enhancer factor TEF-5, TEA domain family member 3
E3593	Panax notoginseng Rhizoma Extract	Panax Notoginseng Rhizoma Extract is extracted from the rhizoma of Panax Notoginseng, which exerts protective effect on metabolic syndrome through MAPK-mediated adipose thermogenic activation.
E3592	Panax notoginseng Root Extract	Panax Notoginseng Root Extract is extracted from the root of Panax Notoginseng, which exerts protective effect on metabolic syndrome through MAPK-mediated adipose thermogenic activation.
E3696	Panax notoginseng Extract	Panax notoginseng Extract is is made from the dry roots of Panax notoginseng, which is used to treat inflammation and bleeding, also inhibits Streptococcus pyogenes without affecting oral commensal bacteria.
E3739	Panax quinquefolium Extract	Panax Quinquefolium Extract is extracted from Panax quinquefolium L. (American Ginseng, AG), its active compounds—ginsenosides—have been documented to exert a wide range of different biological activities resulting in hypoglycemic, anti-inflammatory, cardio protective, and anti-tumor effects.
S3845	Panaxadiol	Panaxadiol (20(R)-Panaxadiol) is a triterpene sapogenin originally found in species of Panax (ginseng) and exhibits anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities. It inhibits Ca2+ channels, decreasing channel open time and open state probability in vitro and displaying anti-arrhythmic potential.
S3847	Panaxatriol	Panaxatriol is a triterpene sapogenin originally found in species of Panax (ginseng) and exhibits anti-inflammatory, hepatoprotective, anti-arrhythmic, and antioxidative activities.
S4825	Pancreatin	Pancreatin (Pancrelipase, Pancreatic enzymes), are commercial mixtures of amylase, lipase, and protease. They are used to treat malabsorption syndrome due to pancreatic problems.(PROTEASE ACTIVITY ≥ 275 USP.u/mg；Amvlase activity ≥ 275 USP.u/mg；Lipase Activity ≥ 22 USP.u/mg)
S2497	Pancuronium dibromide	Pancuronium dibromide is a competitive nicotinic acetylcholine receptor antagonist, used as a muscle relaxant.
E3072	Paniculata Extract	Paniculata Extract is extracted from Microcos paniculata L., which shows various biological functions including antioxidant activity and α-glucosidase inhibitory effect.
A2018	Panitumumab (anti-EGFR)	Panitumumab (anti-EGFR, ABX-EGF) is a recombinant, fully human IgG2 monoclonal antibody that binds to the epidermal growth factor receptor (EGFR).
F1297	Pannexin-1 Antibody [C19F23]
S1030	Panobinostat (LBH589)	Panobinostat (LBH589, NVP-LBH589) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay. Panobinostat (LBH589) induces autophagy and apoptosis. Panobinostat effectively disrupts HIV latency in vivo. Phase 3.
S2105	Pantoprazole	Pantoprazole (SKF96022, BY-1023) is a proton pump inhibitor drug that inhibits gastric acid secretion. It works on gastric parietal cells to irreversibly inhibit (H+/K+)-ATPase function and suppress the production of gastric acid.
S4538	Pantoprazole sodium	Pantoprazole (SKF96022, BY-1023) is a proton pump inhibitor drug that inhibits gastric acid secretion. It works on gastric parietal cells to irreversibly inhibit (H+/K+)-ATPase function and suppress the production of gastric acid.
S5608	Pantoprazole sodium hydrate	Pantoprazole (BY10232, SKF96022) sodium hydrate (Protonix) is a potent inhibitor of H+/K(+)-ATPase with IC50 of 6.8 μM.
E0378	PAP-1	PAP-1 (5-(4-phenoxybutoxy)psoralen), a Kv1.3 antagonist with an EC50 of 2 nM, inhibits the proliferation of human T cells and suppresses delayed type hypersensitivity in rats.
E0149	Papain	Papain (papaya proteinase I) is a sulfhydryl protease from the latex of the papaya fruit. Papain breaks down intercellular matrix of cartilage. Papain can be used to induce animal models of Emphysema.
E3502	Papaya Extract	Papaya Extract is extracted from Carica papaya, which has anticancer activities.
E3503	Papaya Leaf Extract	Papaya Leaf Extract is extracted from the leaves of Carica papaya, which has anticancer, anti-inflammatory, antidiabetic, and antiviral activities.
E0779	Paprotrain	Paprotrain is a cell-permeable inhibitor of the kinesin MKLP-2, inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM and shows a moderate inhibition activity on DYRK1A with an IC50 of 5.5 μM.
S9963	paquinimod	Paquinimod (ABR 25757), a specific inhibitor of S100A8/A9, could rescue the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice.
E8108	PAR-2 (1-6) (human)	PAR-2 (1-6) (human) (SLIGKV), a peptide ligand, is a PAR-2 agonist.
E7144	PAR-4 Agonist Peptide, amide	PAR-4 Agonist Peptide, amide (PAR-4-AP, AY-NH2) is a agonist of proteinase-activated receptor-4 (PAR-4) that provides antinociceptive effects in stress- and inflammation-induced hyperalgesia. It reduces visceral pain by activating PAR-4 receptors on colonic nerve terminals.
F1136	PAR2 Antibody [N9E12]	PAR2,PAR-2
E8252	paracetamol-C2H3	Paracetamol-C2H3 is a deuterated form of 4-acetaminophenol.
E7332	Parathyroid Hormone (1-34), bovine	Parathyroid Hormone (1-34), bovine is a potent parathyroid hormone (PTH) receptor agonist. Parathyroid Hormone (1-34), bovine increases calcium and inorganic phosphate levels in vivo. Parathyroid Hormone (1-34), bovine can be used for th reseach of osteoporosis.
E5192	Paraxanthine	Paraxanthine, a caffeine metabolite, provides protection against Dopaminergic cell death via stimulation of Ryanodine Receptor Channels.
S2444	Parbendazole	Parbendazole (SKF 29044) is an extremely potent inhibitor of microtubule assembly with IC50 of 3 µM for the assembly of brain microtubules.
S0104	Pardoprunox (SLV-308) hydrochloride	Pardoprunox hydrochloride (DU-126891, SME-308) is a potent but partial dopamine D2 receptor agonist with pEC50 of 8.0, and a partial agonist in the induction of [³⁵S]GTPγS binding with pEC50 of 9.2 and a serotonin 5-HT1A receptor agonist, with pEC50 of 6.3, respectively.
S4656	Parecoxib	Parecoxib (SC-69124, Valus-P, Vorth-P) is a selective COX2 inhibitor.
S5418	Parecoxib Sodium	Parecoxib Sodium (SC-69124) is a water-soluble, injectable sodium salt form of parecoxib, which is a potent and selective inhibitor of cyclo-oxygenase-2 (COX2).
E4823	Pargyline	Pargyline is an irreversible selective inhibitor of monoamine oxidase (MAO) with Kis of 13 μM and 0.5 μM for MAO-A and MAO-B respectively. It has pharmaceutical potential as an anticancer drug for human prostate cancer.
S3690	Pargyline hydrochloride	Pargyline is an irreversible inhibitor of monoamine oxidase (MAO)-B with Ki values of 13 and 0.5 μM for time-dependent inhibition of the activity of MAO-A and -B, respectivey.
S6681	Paricalcitol	Paricalcitol is a selective vitamin D receptor agonist. Paricalcitol suppresses parathyroid hormone mRNA expression and inhibits parathyroid cell proliferation. Pariccitol is used to treat secondary hyperparathyroidism in chronic kidney disease.
S9049	Parishin A	Parishin A, isolated from the rhizomes of Gastrodia elata, has good neuroprotective effects against brain disorders.
S9418	Parishin B	Parishin B is a dominant active ingredient originating from Gastrodia elata Blume, and has good neuroprotective effects against brain disorders.
S5404	Paritaprevir (ABT-450)	Paritaprevir (ABT-450) is a nonstructural (NS) protein 3/4A protease inhibitor.
A5352	PARK7 Rabbit Recombinant mAb	PARK7 Rabbit Recombinant mAb detects endogenous level of PARK7.
F1047	PARK7/DJ1 Antibody [C10F17]	DJ-1,PARK7/DJ1,Park7/DJ-1
F0296	Parkin Antibody [H15P18]	PARK2,Parkin
F3602	PARN Antibody [L9K20]
S4183	Paromomycin Sulfate	Paromomycin Sulfate(Aminosidine sulfate) is an aminoglycoside antibiotics inhibiting protein synthesis in non-resistant cells by binding to 16S ribosomal RNA.
E4866	Paroxetine	Paroxetine is a potent and selective serotonin reuptake inhibitor (SSRI) used to treat depression and anxiety disorders. It inhibits pyroptosis and reduces osteoclast formation by blocking the NF-κB signalling pathway.
S3005	Paroxetine HCl	Paroxetine HCl (BRL-29060A, FG-7051) is an antidepressant drug of the SSRI type.
S5239	Paroxetine mesylate	Paroxetine Mesylate(BRL-29060A mesylate,FG-7051 mesylate) is the mesylate salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties.
F2623	PARP1 Antibody [F9N15]	PARP,PARP1
F0148	PARP1 Antibody [N4A5]	PARP,PARP1
E0121	Parsaclisib (INCB050465)	Parsaclisib (INCB050465, INCB-50465, IBI376) is a potent and highly selective PI3Kδ(PI3K delta) inhibitor with an IC50 of 1 nM at 1 mM ATP in biochemical assay and approximately 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases.
E3528	Parsley Extract	Parsley Extract is extracted from Petroselinum crispum, which has pharmacological activity including antioxidant, hepatoprotective, brain protective, anti-diabetic, analgesic, spasmolytic, and immunosuppressant.
A2430	Pascolizumab (Anti-IL-4)	Pascolizumab (Anti-IL-4) is a humanized anti-IL-4 monoclonal antibody. Pascolizumab has the potential for asthma research. MW: 145.5 kD.
S4404	Pasiniazid	Pasiniazid(Paraniazide,Pasiniazide) is a composition of isoniazid and 4-aminosalicylic acid, used to treat tuberculosis patients.
P1127	Pasireotide	Pasireotide (SOM230) is a multi-receptor ligand somatostatin analogue with high binding affinity for somatostatin receptor (SSTR) subtypes sst1,2,3 and sst5. It potently suppresses GH, IGF-I and ACTH secretion, indicating potential efficacy in acromegaly and Cushing’s disease.
E3737	Passiflora caerulea Linnaeus Extract	Passiflora caerulea Linnaeus Extract is drawed from Passiflora caerulea L., which contains higher amounts of the monoamine oxidase (MAO)-inhibitor harmine compared to Passiflora incarnate.
E3044	Passion Fruit Extract	Passion Fruit Extract is extracted from Passiflora edulis Sims.
S3778	Patchouli alcohol	Patchouli alcohol (Patchoulol, Patchouli camphor), an ingredient in pogostemonis herba, has various pharmacological activities and acts as an inhibitor of asexual fungal propagation, inflammation, the influenza virus, and tumorigenesis.
E3046	Patriniae Extract	Patriniae Extract is extracted from Patrinia scabiosaefolia or Patrinia villosa, is able to significantly reduce the biofilm formation and dramatically alters the structure of the mature biofilms of Pseudomonas aeruginosa.
A2506	Patritumab (Anti-ERBB3 / HER3)	Patritumab (Anti-ERBB3 / HER3) is a neutralizing monoclonal antibody targeting ERBB3. Patritumab shows a synergy with Cetuximab, potently inhibits the phosphorylation of EGFR, HER2, HER3, ERK, and AKT. Patritumab also induces cell apoptosis and suppresses the growth of pancreatic, non-small cell lung cancer, and colorectal cancer xenograft tumors. MW: 145.5 KD.
D4004	Patritumab deruxtecan	Patritumab deruxtecan (HER3-DXd) is an antibody-drug conjugate (ADC) composed of a fully human anti-HER3 IgG1 monoclonal antibody and a cytotixic topoisomerase I inhibitor. Patritumab deruxtecan shows anticancer activity.
S1364	Patupilone (Epothilone B)	Patupilone (EPO906, Epothilone B) is a microtubule-stabilizing agent with EC_0.01 of 1.8 μM. Phase 2.
A5173	Pax2 Rabbit Recombinant mAb	Pax2 Rabbit Recombinant mAb detects endogenous level of total Pax2.
F5076	PAX5 Antibody [A13D19]
F1006	PAX5 Antibody [M18F13]	PAX5,Pax-5
A5371	PAX6 Rabbit Recombinant mAb	PAX6 Rabbit Recombinant mAb detects endogenous level of total PAX6.
A5679	PAX7 Rabbit Recombinant mAb	PAX7 Rabbit Recombinant mAb detects endogenous level of total PAX7.
F2154	PAX8 Antibody [J6L24]
A5556	PAX9 Rabbit Recombinant mAb	PAX9 Rabbit Recombinant mAb detects endogenous level of total PAX9.
S8163	Paxalisib (GDC-0084)	Paxalisib (GDC-0084, RG7666) is a brain penetrant inhibitor of PI3K and mTOR with Kiapp values of 2 nM, 46 nM, 3 nM, 10 nM and 70 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR.
F1106	Paxillin Antibody [N7H16]
E1311	Paxilline	Paxilline, an indole alkaloid mycotoxin derived from Penicillium paxilli, potently inhibits the BK channel by exerting its effects through direct channel inhibition. Additionally, Paxilline also functions as an inhibitor of sarco/endoplasmic reticulum Ca2+-stimulated ATPase (SERCA), with IC50 values ranging from 5 μM-50 μM, depending on the SERCA isoform. Paxilline also possesses significant anticonvulsant and neuroprotective effects.
S3012	Pazopanib	Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms/CSF1R with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, respectively. Pazopanib induces cathepsin B activation and autophagy.
S1035	Pazopanib HCl	Pazopanib HCl is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, respectively. Pazopanib induces autophagic Type II cell death.
S3621	Pazufloxacin mesylate	Pazufloxacin Mesylate (T-3762, Pazucross), also known as Pazucross and T-3762, is a quinolone antibacterial agent used for the intravenous therapy of several infections.
E7054	PAβN dihydrochloride	PAβN dihydrochloride (MC-207110 dihydrochloride) is an efflux pump inhibitor.
H2995	PB BCRP1 Antibody [5D3]	Breast cancer resistance protein (BCRP1), also known as placenta-specific ATP-binding cassette (ABC) protein (ABCP) or ABC G-subfamily member 2 (ABCG2), or mitoxantrone resistance protein (MXR), is a member of the ATP-binding cassette superfamily of drug transporters thought to be involved in multi-drug resistance in human neoplastic disease. ABCG2 is expressed in drug-resistant breast, colon and gastric cancer and fibrosarcoma cancer cell lines and in blast cells from patients with acute myeloid leukemia (AML). Normal tissues that express the ABCG2 protein include placental syncytiothrophoblasts, mammary ducts and lobules, epithelium in the large intestine and colon, venous and capillary epithelium and bile canalicular membrane of the live
G3460	PB CD105/Endoglin Antibody [MJ7/18]	CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up-regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation-associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.
G4060	PB CD117/c-Kit Antibody [2B8]	KIT (c-KIT), also known as CD117, is a proto-oncogene and a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). KIT was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT together with its ligand regulates growth and activation of a variety of hemopoietic and non-hemopoietic cells. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Recently, deregulation of the KIT receptor TK by the prevalent activation loop mutation D816V has served as a focal point in therapeutic strategies aimed at curbing neoplastic mast cell growth. c-Kit is expressed in hematopoietic stem cells, germ cell
G0100	PB CD11c Antibody [N418]	CD11, along with CD18, form a heterodimer adhesion molecule. In particular, CD11 is composed of CD11a, CD11b and CD11c. CD11a is a leukocyte marker that is expressed in B and T lymphocytes, macrophages, monocytes, neutrophils, basophils and eosinophils. CD11b is primarily expressed by monocytes, macrophages, natural killer cells, some B and T-cells, and granulocytes. CD11c is expressed in monocytes, macrophages, natural killer cells, some granulocytes and less so in a subset of lymphocytes.
H1300	PB CD18 Antibody [YFC118.3]	CD18 is an integral membrane glycoprotein of ~95 kDa, also known as the beta 2 chain of the LFA-1 complex. CD18 non-covalently links to CD11a, b, or c molecules to form the heteromeric LFA-1 complex. CD18 acts as the receptor for ICAM-1 and is important for cell adhesion and cell-cell interactions.
G1720	PB CD1d Antibody [1B1]	CD1d is a heavy chain associated with Beta 2 microglobulin on cortical thymocytes. Beta 2 microglobulin independent expression of CD1d has also been demonstrated on human intestinal epithelial cells. CD1d is the sole group 2 member of the CD1 family of major histocompatibility (MHC) like glycoproteins. The CD1d gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1
G4135	PB CD23 Antibody [B3B4]	CD23 is a 45 kDa glycoprotein that serves as a low-affinity receptor for IgE, playing a crucial role in regulating IgE responses and B cell activation. It is expressed on mature B cells, mantle zone B cells, follicular dendritic cells, and at lower levels on T cells, NK cells, Langerhans cells, and platelets. CD23 expression is upregulated upon B cell activation, and its soluble forms are biologically active, acting as potent mitogenic factors. CD23 is strongly expressed on Epstein-Barr virus (EBV)-transformed B lymphoblasts and is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells. It is also detected in neoplastic cells from cases of B cell chronic lymphocytic leukemia and some centroblastic/centrocytic lym
G0280	PB CD24 Antibody [M1/69]	CD24 is a 35-50 kDa glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed on a variety of cell types, including erythrocytes, thymocytes, peripheral lymphocytes, and cells of the myeloid lineage. It is variably glycosylated, resulting in heterogeneity in molecular mass across different cell lineages, which can affect antibody staining levels on lymphocyte populations. In the context of B-cell development, CD24 is expressed from the pro-B-cell stage in the bone marrow through to mature, surface Ig-positive B cells, with very low or negative expression on plasma cells. It is also present on the majority of B-lineage acute lymphoblastic leukemias, B-cell chronic lymphocytic leukemias (CCLs), and B-cell non-Hodgkin's lymphomas. CD2
H0175	PB CD27 Antibody [O323]	CD27 (TNFRSF7) is a cell surface homodimer of ≥55 kDa subunits that provides co-stimulatory signaling in support of T cell (TCR) and B cell (BCR) receptors. Compared to CD28, whose TCR co-stimulatory signal can trigger cell proliferation, CD27 signaling promotes cell survival and differentiation to effector/memory stages. CD27 may be shed following interaction with its ligand CD70, which is typically expressed on activated dendritic cells, T cells, and B cells. In B cells, CD27 is a phenotypic marker for memory B cells and has also been included among markers for identifying B regulatory cells (Bregs), which regulate CD4+ T cell proliferation and Foxp3/CTLA-4 expression in Treg cells.
G0085	PB CD44 Antibody [IM7]	CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential. CD44 is expressed by hematopoietic, non-hematopoietic cells, epithelial tissu
G0025	PB CD45 Antibody [30-F11]	CD45, also known as Leukocyte Common Antigen (LCA). CD45 is expressed by all hematopoietic cells excluding mature erythrocytes and platelets. The cytoplasmic portion of CD45 has tyrosine phosphatase enzymatic activity and plays an important role in activation of lymphocytes.
G0355	PB CD45.1 Antibody [A20]	CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides t
G0115	PB CD45R/B220 Antibody [RA3-6B2]	CD45R (PTPRC) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. CD45 contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. CD45 is specifically expressed in hematopoietic cells and has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists in multiple isoforms as a result of alternative splicing, and these isoforms di
G0250	PB CD62L/L-Selectin Antibody [MEL-14]	The human CD62L is a 74-95 kDa glycoprotein member of the selectin family of adhesion receptors. L-Selectin is comprised of an aminoterminal C-type lectin binding domain, an epidermal growth factor-like domain, two short consensus repeat (SCR) sequences homologous to those found in complement binding proteins, a short spacer region, a transmembrane region and a short cytoplasmic region. Human CD62L (L-Selectin) is constitutively expressed on all classes of leukocytes including lymphocytes (except a substantial population of memory T cells), monocytes and polymorphonuclear cells.
G0505	PB CD68 Antibody [FA-11]	CD68 is considered a pan-macrophage marker, predominantly expressed on the intracellular lysosomes of tissue macrophages/monocytes, including Kupffer cells, microglia, histiocytes and osteoclasts, and is expressed to a lesser extent by dendritic cells and peripheral blood granulocytes. CD68 is expressed by many tumor types including some B cell lymphomas, blastic NK lymphomas, melanomas, granulocytic (myeloid) sarcomas, hairy cell leukemias, and renal, urinary and pancreatic tumors, and can be used to demonstrate the presence/localization of macrophages.
G0220	PB CD80/B7-1 Antibody [16-10A1]	CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28, and of an inhibitory receptor CTLA-4 (CD152). Both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, and both molecules can also substitute for each other in this process. CD80 is rapidly induced on the surface of in vitro activated B cells, with Epstein Barr Virus (EBV) transformed B cell lines, with Burkitts lymphoma cell lines, with freshly isolated follicular B lymphoma cells, T cells, and monocytes. The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 and CTLA4 ligands of T cells. Diseases associated with CD80 dysfunct
G0010	PB CD8a Antibody [53-6.7]	CD8 (Cluster of differentiation 8), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, plays an integral role in signal transduction, and T cell differentiation and activation. CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8alpha and CD8beta, where it functions as a co-receptor, along with T cell receptor (TCR), for major histocompatibilty complex class I (MHC-I) molecules; whereas its counterpart, CD4, acts as a co-receptor for MHC-II molecules. CD8 exists on the cell surface, where the CD8alpha chain is essential for binding to MHC-I. CD8 is also expressed on a subset of T cells, NK cells, monocytes and dendritic cells as disulfide-linked homodimers of CD8alpha. Ligation of MH
G0070	PB F4/80 Antibody [BM8]
H0775	PB FCER1A Antibody [AER-37 (CRA1)]	Fc epsilon RI alpha, also known as FcεRIα, is a subunit of the high-affinity receptor for IgE, primarily expressed on mast cells and basophils. Its expression is upregulated by the presence of IgE. FcεRIα forms a tetrameric complex with one beta and two gamma subunits, which are essential for signal transduction. The beta and gamma subunits contain immunoreceptor tyrosine-based activation motifs (ITAMs). The FcεRI complex plays a crucial role in triggering IgE-mediated allergic reactions. When allergen-bound IgE molecules bring together two or more high-affinity IgE receptors, it leads to the release of mediators such as histamine, which are responsible for allergy symptoms. This process couples allergens and mast cells to initiate inflamma
H0400	PB Granzyme B Antibody [GB11]	Granzyme B is a member of the granzyme serine protease family, and is found in the granules of cytotoxic T cells and NK cells. Granzyme B has been described as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation, and CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells. Granzyme B is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. The receptor involved in this process has been identified as mannose 6-phosphate receptor which functions as a death receptor for Granzyme B during cytotoxic T cell-induced ap
G1825	PB Helios Antibody [22F6]
H0460	PB Human CD107a Antibody [H4A3]	CD107a, also known as Lysosomal-associated membrane protein 1 (LAMP-1), is a ~110 kDa type I transmembrane protein that is heavily glycosylated and widely expressed by cells primarily on the luminal surface of their lysosomes. It is also expressed on the surface of activated platelets, activated lymphocytes, cytotoxic T cells and NK cells, and some tumor cell lines, including U937 and KG1a. LAMP-1 can serve as a ligand for E-selectin-mediated cell adhesion. LAMP-1 and LAMP-2 (CD107b) are carriers for poly-N-acetyllactosamines and are able to display sialyl Le[x] termini.
H0070	PB Human CD11b Antibody [ICRF44]	CD11b is a 165-170 kD type I transmembrane glycoprotein also known as αM integrin, Mac-1, CR3, and C3biR. CD11b non-covalently associates with integrin β2 (CD18) and is expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b/CD18 is critical for the transendothelial migration of monocytes and neutrophils. It is also involved in granulocyte adhesion, phagocytosis, and neutrophil activation. CD11b/CD18 interacts with ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4, CD14, CD23, heparin, iC3b, fibrinogen, and factor X.
H0145	PB Human CD11c Antibody [3.9]	CD11c is a 145–150 kDa type I transmembrane glycoprotein also known as integrin αx and CR4. CD11c non-covalently associates with integrin β2 (CD18) and is expressed on monocytes/macrophages, dendritic cells, granulocytes, NK cells, and subsets of T and B cells. CD11c has been reported to play a role in adhesion and CTL killing through its interactions with fibrinogen, CD54, and iC3b.
H1135	PB Human CD16 Antibody [3G8]	CD16a is a ~50–65 kDa type I transmembrane glycoprotein encoded by FCGR3A (Fc fragment of IgG receptor IIIa), which belongs to the immunoglobulin superfamily. CD16a is also known as Fc-gamma RIII-alpha (FcγRIIIA or FcRIIIa) and is expressed on natural killer (NK) cells, activated monocytes, macrophages, γδ T cells, immature thymocytes, and mast cells. CD16a binds immune-complexed or aggregated IgG and associates with CD247/TCRζ in NK cells and FcεRIγ chains in phagocytes and mast cells to transduce intracellular signals. CD16a functions in antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses including phagocytosis, cytokine production, or mediator release. CD16b is a ~48 kDa glycophosphatidylinositol (GPI)-
H0010	PB Human CD19 Antibody [HIB19]	CD19 is a 95 kDa type I transmembrane glycoprotein expressed during all stages of B-cell maturation and differentiation, except on plasma cells. It is also present on follicular dendritic cells but not found on T cells or normal granulocytes. CD19 functions as a signal transduction molecule that regulates B cell development, activation, proliferation, and differentiation. It associates with complement receptor 2 (CD21), TAPA-1 (CD81), Leu 13, and/or MHC class II to form a signal transduction complex on the surface of B cells.
H0025	PB Human CD19 Antibody [LT19]	CD19 is a type I transmembrane glycoprotein of 95 kDa that belongs to the immunglobulin superfamily. CD19 is expressed on B cells throughout most stages of B cell differentiation, though its expression is down-regulated during their terminal differentiation to plasma cells. Expression of CD19 is also found in the majority of B cell–derived malignancies. CD19 is further present on follicular dendritic cells. On B cells, CD19 associates with CD21, CD81, and CD225 (Leu-13) forming a signal transduction complex.
H1585	PB Human CD1a Antibody [HI149]	CD1a is a type I transmembrane glycoprotein. The 49 kDa CD1a polypeptide is associated with β2-microglobulin. CD1a is expressed on cortical thymocytes, dendritic cells and Langerhans cells. CD1a has structural similarities to the MHC class I antigen, and plays a role in antigen presentation.
H1600	PB Human CD1c Antibody [L161]	CD1c, also known as R7 or M241, is a 43 kD member of the five CD1 antigens (CD1a-e) in humans. The CD1 molecules are type I glycoprotein with structural similarities to MHC class I and are non-covalently associated with β2-microglobulin, belonging to the Ig superfamily. CD1c is expressed on cortical thymocytes, Langerhans cells, dendritic cells, and a subset of B cells. It has been reported that CD1c is also expressed on mature T cells in a tightly regulated manner. CD1c is involved in antigen-presentation of glycolipids. It may also act in T cells as an immune regulatory molecule.
H1165	PB Human CD20 Antibody [2H7]	CD20 is a 33-37 kD, four transmembrane spanning protein, also known as B1 and Bp35. CD20 is expressed on pre-B-cells, resting and activated B cells (not plasma cells), some follicular dendritic cells, and at low levels on a T cell subset. CD20 is heavily phosphorylated on activated B cells and malignant B cells. Homo-oligomeric complexes of CD20 are thought to form Ca2+ conductive ion channels in the plasma membrane of B cells. The CD20 molecule is involved in B-cell activation and is associated with various Src family kinases (Lyn, Lck, Fyn). It exists in a complex with MHC class I and II, CD53, CD81, and CD82.
H4255	PB Human CD25 Antibody [M-A251]
H4105	PB Human CD28 Antibody [CD28.2]	CD28 is a 44 kDa homodimeric transmembrane glycoprotein expressed on most mature T cells, thymocytes, and plasma cells. It acts as a costimulatory receptor, binding to CD80 and CD86 ligands, and plays a crucial role in T cell-B cell interactions. CD28 is believed to initiate and regulate a distinct signal transduction pathway that is separate from those stimulated by the TCR complex. The binding of CD28 to its ligands can also influence immune responses, including the production of IL-2 and changes in intracellular calcium concentrations.
H4360	PB human CD3 Antibody [UCHT1]
H1510	PB Human CD304 Antibody [12C2]
H0235	PB Human CD31 Antibody [WM59]	CD31 (PECAM-1), also known as GPIIA' or EndoCAM, is a 130 kDa type I transmembrane glycoprotein belonging to the Ig gene superfamily. It is widely expressed on platelets, monocytes, granulocytes, NK cells, T cell subsets, and in high amounts on endothelial cells. CD31 functions as a vascular endothelial cell adhesion molecule, playing a critical role in the transendothelial migration of leukocytes during inflammatory responses. It is also involved in thrombosis, angiogenesis, and wound healing. The antibody against PECAM-1 binds to an epitope near extracellular domain 2 of CD31. Clone WM59 also cross-reacts with peripheral blood platelets and leukocytes of baboon, and both rhesus and cynomolgus macaque monkeys. The staining intensity of WM5
H3655	PB Human CD366 Antibody [F38-2E2]	CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells). Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance.
H0040	PB Human CD4 Antibody [RPA-T4]	CD4 is a 56 kDa transmembrane glycoprotein expressed on the T-helper/inducer subset of normal human peripheral blood lymphocytes. The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex
H0565	PB Human CD40 Antibody [5C3]	CD40 is a 45–48 kDa type I transmembrane glycoprotein primarily expressed on B lymphocytes, though it is absent on terminally differentiated B cells. It is also found on endothelial cells, basal epithelial cells, certain epithelial cell carcinomas, follicular dendritic cells, macrophages, fibroblasts, keratinocytes, and CD34+ hematopoietic progenitor cells. CD40 plays a critical role in B-cell growth, proliferation, and differentiation, including immunoglobulin isotype switching. Engagement of CD40, particularly in the presence of IL-4 or costimulation with anti-µ or anti-CD20 antibodies, can promote B-cell proliferation.
H0895	PB Human CD41a Antibody [HIP8]	CD41a, also known as Integrin αIIb or Platelet GPIIb, forms a calcium-dependent complex with CD61 (β3 integrin or GPIIIa) that is normally expressed on platelets and megakaryocytes. The CD41/CD61 complex serves as a receptor for fibrinogen, fibronectin, and von Willebrand factor, mediating platelet adhesion and aggregation. Blocking CD41 can completely inhibit ADP-, epinephrine-, and collagen-induced platelet activation, and partially inhibit ristocetin- and thrombin-induced activation.
H0100	PB Human CD45 Antibody [HI30]	CD45 is encoded by the PTPRC (Protein tyrosine phosphatase receptor type C) gene. CD45, also known as the leukocyte common antigen (LCA), is a member of the protein tyrosine phosphatase (PTP) family. It is present on all human leukocytes including lymphocytes, monocytes, granulocytes, eosinophils, and thymocytes. CD45 is absent from circulating erythrocytes, platelets, or mature erythroid cells of bone marrow and non-hemopoietic tissues.
H0745	PB Human CD45RA Antibody [HI100]	CD45RA, a 220 kDa isoform of the human leukocyte common antigen, is expressed on approximately 40–50% of peripheral CD4+ T cells, 50% of peripheral CD8+ T cells, and on a portion of B cells and monocytes. The CD45RA antigen is expressed by naïve and activated T cells. CD45RA-specific antibodies are useful for the study of the suppressor/inducer subpopulation of CD4+ lymphocytes.
H0535	PB Human CD49f Antibody [GoH3]	CD49f, also known as the integrin α6 chain, is a ~150 kDa type I transmembrane glycoprotein that belongs to the integrin alpha chain family of extracellular matrix and cell adhesion receptors. The integrin α6 subunit associates with the integrin β1 chain (CD29) to form VLA-6, and with the integrin β4 chain (CD104) to form the integrin α6β4 complex, also known as the laminin and kalinin receptor. CD49f is expressed mainly on T cells, monocytes, platelets, epithelial cells, endothelial cells, perineural cells, and trophoblasts of the placenta. Antibodies against CD49f can block the binding of integrin α6 to laminin P1 and E8 fragments.
H1255	PB Human CD54 Antibody [HA58]	CD54, also known as Intercellular Adhesion Molecule 1 (ICAM-1), is an 85-110 kDa type I transmembrane glycoprotein that belongs to the immunoglobulin supergene family. A soluble form of CD54 can also be found in biological fluids. CD54 is expressed on endothelial cells, as well as on both resting (weak) and activated (moderate) lymphocytes and monocytes. It serves as a ligand for LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). The CD54 adhesion molecule plays a key role in inflammatory and immune responses, as well as in neoplasia.
H1330	PB Human CD63 Antibody [H5C6]	CD63 is a 53 kDa, type III lysosomal glycoprotein that belongs to the tetraspan transmembrane 4 superfamily (TM4SF). It is expressed on activated platelets, monocytes, and macrophages, and is also known by several other names, including LIMP, gp55, melanoma-associated antigen ME491, Pltgp40, and LAMP-3. CD63 is widely expressed on the surface and in the cytoplasm of various hematopoietic cells (such as monocytes and macrophages) as well as non-hematopoietic cells (including endothelium, fibroblasts, osteoclasts, and smooth muscle cells). It plays a key role in mediating cellular adhesion and motility.
H0370	PB Human CD73 Antibody [AD2]	CD73, also known as ecto-5'-nucleotidase, is a 70 kDa, glycosyl phosphatidylinositol (GPI)-anchored glycoprotein. CD73 is expressed on subsets of T and B lymphocytes, follicular dendritic cells, epithelial cells, endothelial cells and mesenchymal stem cells. Its expression on lymphocytes increases during T and B cell development. CD73 has enzymatic activity and catalyzes the dephosphorylation of adenosine monophosphate (AMP), converting it to adenosine. It has been suggested that CD73 can mediate costimulatory signals in T cell activation and adhesion of lymphocytes to endothelium.
H0550	PB Human CD8 Antibody [SK1]	CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.
H2080	PB Human Granzyme A Antibody [CB9]
H1795	PB Human HLA-A2 Antibody [BB7.2]	HLA-A2 is a class I molecule of the major histocompatibility complex (MHC) and part of the highly polymorphic group of cell-surface proteins encoded by the MHC gene locus. It plays a crucial role in the immune response by binding and presenting small antigenic protein fragments to antigen-specific receptors on T cells (TCR). Class I MHC molecules, like HLA-A2, bind peptides derived from intracellular antigens, such as viral and some bacterial antigens, which are recognized by CD8+ T cells. The TCRs recognize these processed peptides bound to the MHC, as well as regions of the MHC molecule itself, while CD4 and CD8 accessory molecules enhance the interaction by binding non-polymorphic regions of the MHC.
H3685	PB Human Ig light chain lambda Antibody [MHL-38]
H3670	PB Human Ig light chain κ Antibody [MHK-49]
H3700	PB Human IgD Antibody [IA6-2]	IgD is a member of the immunoglobulin superfamily that exists in type 1-membrane (mIgD) and soluble glycoprotein forms. mIgD is expressed on mature naïve B cells (along with membrane IgM) and serves as a B-cell receptor for antigen (BCR). In response to antigen binding, the mIgD BCR, in association with other signaling molecules including CD79a and CD79b, can transduce activating or tolerizing signals intracellularly into B lymphocytes.
H1015	PB Human IgM Antibody [MHM-88]	IgM is the first immunoglobulin made by B cells in the immune response. Surface IgM is expressed on immature and mature B cells, while IgM heavy (μ) chain is expressed intracellularly in pre-B cells.
H1225	PB Human IL-2 Antibody [MQ1-17H12]	Interleukin-2 (IL-2) is a key cytokine involved in immune response and tolerance. It is produced by activated T cells and plays a crucial role in the activation, growth, proliferation, and differentiation of various immune cells, including T and B lymphocytes, LAK cells, NK cells, and monocytes/macrophages. IL-2 exerts its effects through binding to IL-2 receptor complexes, which include the intermediate-affinity IL-2R (comprising IL-2Rβ and γc) and the high-affinity IL-2R (which also includes IL-2Rα, along with IL-2Rβ and γc). IL-2 is essential for the proper functioning of the immune system, particularly in promoting T cell expansion and immune responses.
H1495	PB Human TCR α/β Antibody [IP26]
H0130	PB IFN-gamma Antibody [4S.B3]	IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor and immune interferon that is produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemagglutinin, and other cytokines. IFN gamma is a dimeric protein consisting of two 146 amino acid subunits. IFN gamma is a glycoprotein that exists functionally as a homodimer of approximately 45 kDa. On SDS-PAGE, IFN gamma appears as a combination of 25, 20, and minor 15.5 kDa bands as a result of differential glycosylation. The biological activity of the IFN gamma homodimer is highly species specific. Human IFN gamma does not show cross-reactivity with mouse. IFN gamma exhibits functions such as a
G1930	PB IL-6 Antibody [MQ2-13A5]
G0370	PB Ly-6A/E/Sca-1 Antibody [D7]	Stem Cell Antigen-1 (Sca-1) is a member of the lymphocyte antigen 6 (Ly-6) family. It is expressed on multipotent hematopoietic stem cells (HSC) and is used as a marker of HSC in mice. Sca-1 is used in combination with lineage depletion antibodies to identify murine HSC. Sca-1 can be found in fetal liver, adult bone marrow, and adult peripheral blood and spleen. Sca-1 may be involved in the regulation of B and T cell activation.
G4645	PB Mouse CD3 Antibody [17A2]	CD3ε is one of five polypeptide chains that combine to form the TCR complex. CD3ε is expressed on T lymphocytes, NK-T cels, and to varying degrees on developing thymocytes. CD3 plays roles in TCR signaling, T lymphocyte activation, and antigen recognition.
G1420	PB Mouse CD317 Antibody [927]
G0850	PB Mouse CD38 Antibody [90]	CD38 is a 45 kD type II transmembrane glycoprotein also known as T10. It is an ADP-ribosyl hydrolase expressed at variable levels on hematopoietic cells and in some non-hematopoietic tissues (such as brain, muscle, and kidney). In humans, it is expressed at high levels on plasma cells and activated T and B cells, natural killer (NK) lymphocytes, myeloblasts, and erythroblasts. By functioning as both a cyclase and a hydrolase, CD38 mediates lymphocyte activation, adhesion, and the metabolism of cADPR and NAADP. CD31 is the ligand of CD38.
G4150	PB Mouse CD4 Antibody [GK1.5]	The CD4 antigen is a 55 kDa cell surface type I membrane glycoprotein belonging to the immunoglobulin superfamily. CD4 acts as a co-receptor which, in cooperation with the T cell receptor (TCR), interacts with class II MHC molecules displayed by antigen-presenting cells (APC). CD4 is expressed by the majority of thymocytes, most helper T cells, a subset of NK-T cells, and weakly by dendritic cells and macrophages. CD4 plays an important role in the development of T cells and is required for mature T cells to function optimally.
G0535	PB Mouse CD49b Antibody [DX5]	CD49b is a 150 kDa transmembrane glycoprotein that non-covalently associates with CD29 (integrin β1) to form the integrin α2β1 complex known as VLA-2. The rat anti-mouse CD49b antibody has been reported to identify the majority of NK cells and a small T-cell subpopulation in most mouse strains (e.g., A/J, AKR, BALB/c, C3H/HeJ, C57BL/6, C57BL/10, C57BR, C58, CBA/Ca, DBA/1, DBA/2, SJL, SWR, 129/J, but not NOD). The DX5 antibody also recognizes platelets that express high levels of CD49b.
G1120	PB Mouse CD54 Antibody [YN1/1.7.4]	CD54 is a 90 kD immunoglobulin superfamily member also known as ICAM-1 and Ly-47. It is expressed on activated endothelial cells, high endothelial venules (HEV), T and B cells, monocytes/ macrophages, granulocytes, and dendritic cells. CD54 is an important intracellular adhesion molecule that participates in T cell-T cell, T cell-B cell, and T cell-target cell interactions via binding of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). CD54 has also been shown to be involved in lymphocyte trafficking, making it an important molecule in many immune reactions and inflammation. CD54 is also a receptor for rhinovirus. Antibodies against CD54 can block its interaction with LFA-1 and Mac-1, thereby inhibiting cell-cell adhesion, impairing antigen prese
G4855	PB Mouse CD8β Antibody [53-5.8]
G1810	PB Mouse H-2Kb Antibody [AF6-88.5]	H-2Kb is a mouse MHC class I alloantigen expressed on all nucleated cells of mice with the H-2^b haplotype. It plays a key role in presenting endogenous peptides to CD8+ T cells, enabling immune surveillance and cytotoxic T cell responses.
G1510	PB Mouse I-A[b] Antibody [AF6-120.1]
G4195	PB Mouse IgG1 isotype control Antibody [MOPC-21]	Mouse IgG1 isotype control is a mouse myeloma protein. It was selected as an isotype control following screening for low background on a variety of mouse and human tissues.
G0880	PB Mouse IgG2a κ Isotype Control Antibody [G155-178]
G0790	PB Mouse IL-10 Antibody [JES5-16E3]	IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. D
G4435	PB Mouse Ly6G Antibody [1A8]	Lymphocyte antigen 6 complex, locus G (Ly-6G), is a 21–25 kDa GPI-anchored protein expressed primarily on peripheral granulocytes and highly specific for neutrophils. Ly-6G serves as a robust marker for neutrophil identification and depletion in mice. Ly-6G modulates neutrophil migration and recruitment to sites of inflammation via interaction with β2 integrins. Its downregulation is associated with age-related functional decline in neutrophils.
G4345	PB Mouse Ly6G/Ly6C Antibody [RB6-8C5]	Lymphocyte antigen 6 complex, locus G (Ly-6G), also known as Ly6C, Gr-1, is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein with a molecular weight of approximately 21–25 kDa. It is commonly used as a specific marker for peripheral granulocytes, particularly neutrophils, in mice. Ly-6G is predominantly expressed on myeloid-derived cells in the bone marrow and exhibits high specificity for neutrophils, though it can also be detected on some monocytes and granulocyte subsets. This specificity makes Ly-6G a robust marker for identifying and studying neutrophil populations and their roles in immune responses in murine models.
G4255	PB Mouse NK1.1 Antibody [PK136]	NK1.1, also known as CD161b/CD161c, KLRB1, NKR-P1A, and Ly-55, is a type II integral membrane glycoprotein with a C-type lectin domain and is encoded by the Klrb1c/NKR-P1C gene. NK1.1 plays roles in NK cell activation and differentiation, IFN-γ production, cytotoxic granule release, and is thought to be involved in the generation of Th2 cells. NK1.1 is predominantly expressed as a disulfide-linked homodimer on NK cells; however, it is also expressed on NK-T cells, a rare population of T lymphocytes. NK1.1 is only expressed by C57BL/6, FVB/N, and NZB strains of mice and not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129 strains.
G1675	PB Mouse TCR Vα2 Antibody [B20.1]	TCR Vα2 is a distinct T-cell receptor (TCR) subfamily found in mice with the a, b, and c haplotypes. The TCR α chain complexes with the TCR β chain in 95% of T cells, forming the T cell receptor (α/β TCR), while the remaining 5% of T cells express gamma (γ) and delta (δ) chains (γ/δ TCR). TCR Vα2 represents a specific variant of the TCR α chain that plays a role in antigen recognition and is useful in the study of T-cell function and immune responses in mice with these specific haplotypes.
G4360	PB Mouse Ter-119 Antibody [TER-119]	TER-119 is a lineage marker for erythroid cells from early proerythroblast to mature erythrocyte stages in adult blood, spleen, and bone marrow. It is also present in yolk sac, and fetal and newborn liver. The TER-119 antigen is not expressed by cells of earlier erythroid development at BFU-e (blast-forming unit erythroid) stage or CFU-e (colony-forming unit erythroid) stage.
G4675	PB mouse/human CD11b Antibody [M1/70]
G0625	PB T-bet Antibody [B2D24]	T-bet, also known as TBX21, is a T-cell specific transcription factor containing a single T-box DNA-binding domain. It controls the expression of the TH1 cytokine, interferon-gamma. Both Th1 and Th17 cells are crucial in immune regulation and autoimmune disease development. T-bet initiates Th1 lineage development from naive Th precursor cells and directs T cell differentiation to Th1 versus Th17. T-bet is cooperating with Stat4 (signal tranducer and activator of transcription 4) in programming chromatin architecture for Th1 gene expression. Genetic variations in T-bet are associated with susceptibility to aspirin-induced asthma and nasal polyps.
G4030	PB TCF1/TCF7 Antibody [E19C1]	LEF1 and TCF are members of the high mobility group (HMG) DNA-binding protein family of transcription factors that consists of the following: Lymphoid Enhancer Factor 1 (LEF1), T Cell Factor 1 (TCF1/TCF7), TCF3/TCF7L1, and TCF4/TCF7L2. LEF1 and TCF1/TCF7 were originally identified as important factors that regulate early lymphoid development and act downstream in Wnt signaling. LEF1 and TCF bind to Wnt response elements to provide docking sites for β-catenin, which translocates to the nucleus to promote the transcription of target genes upon activation of Wnt signaling. LEF1 and TCF are dynamically expressed during development and aberrant activation of the Wnt signaling pathway is involved in many types of cancers, including colon cancer.
G0295	PB TCR-β Antibody [H57-597]	The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system c
G0340	PB TNF-α Antibody [MP6-XT22]
E5948	PB94	PB94 is a potent and selective inhibitor of HDAC11 with an IC50 of 108 nM and exhibits >40-fold selectivity over other HDAC isoforms. It ameliorates neuropathic pain in mouse models and can be radiolabeled with carbon-11 as [¹¹C]PB94 for PET imaging, demonstrating significant brain uptake and potential for in vivo imaging applications.
S0529	PBD-150	PBD-150 is a potent human glutaminyl cyclase (hQC) Y115E-Y117E variant inhibitor with Ki of 60 nM.
E1733	PBIT	PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1 (JARID1) enzymes. It inhibits JARID1B (KDM5B/PLU1), JARID1Aand JARID1C with an IC50 of 3 μM, 6 μM and 4.9 μM respectively. It is capable of inhibiting the multiplication of breast cancer cell lines expressing high levels of JARIDB1.
F3332	PBK/SPK Antibody [L14M16]	PBK/SPK,PBK/TOPK
F1584	PBR Antibody [G18J3]	PBR,TSPO
S6549	PBTZ169	PBTZ169 (macozinone), an antibiotic with antimycobacterial activity, is an irreversible inhibitor of DprE1.
F3654	Pbx3 Antibody [A4N18]
F1491	PC Antibody [B18K17]	PC2,PCSK2
F0642	PCAF Antibody [B2K11]
F4324	PCBP2 Antibody [L1D11]
F2812	PCDH7 Antibody [A6K3]
S6725	PCI 29732	PCI 29732 is a selective and irreversible Btk inhibitor with an IC50 of 0.5 nM.
S2012	PCI-34051	PCI-34051 is a potent and specific HDAC8 inhibitor with IC50 of 10 nM in a cell-free assay. It has greater than 200-fold selectivity over HDAC1 and 6, more than 1000-fold selectivity over HDAC2, 3, and 10. PCI-34051 induces caspase-dependent apoptosis.
F0697	PCK1 Antibody [P16P6]	PCK1,PCK1/PEPC
F1007	PCK2 Antibody [A2C10]	PCK2 Rabbit mAb detects endogenous levels of total PCK2 protein.
F0018	PCNA Antibody [N10L6]	PCNA,Proliferating Cell Nuclear Antigen
S4476	PCNA-I1	PCNA-I1 is a selective inhibitor of proliferating cell nuclear antigen (PCNA, a potential anticancer target). PCNA-I1 selectively binds to PCNA trimers with Kd of ~0.2 to 0.4 μM. PCNA-I1 inhibits the growth of tumor cells of various tissue types with IC50 of ~0.2 μM. PCNA-I1 induces DNA damage and apoptosis in both LNCaP and PC-3 cells. PCNA-I1 also induces autophagy in PC-3 cells.
E1889	PCO371	PCO371 is a nonpeptidyl, orally active agonist of Parathyroid hormone type 1 receptor (PTHR1). It stimulates cAMP production in COS-7 cells with an EC50 of 2.4 μmol/L. It also acts as an osteoporosis drug and significantly enhances bone mineral density (BMD) and bone strength in the lumbar vertebrae of osteopenic ovariectomized (OVX) rats. It also restores normal serum calcium levels without increasing urinary calcium in hypocalcemic thyroparathyroidectomized (TPTX) rats.
E7065	PCPA methyl ester hydrochloride	PCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride), a reversible tryptophan hydroxylase inhibitor, is a serotonin (5-HT) synthesis inhibitor. PCPA methyl ester hydrochloride crosses the blood brain barrier and reduces 5-HT central availability.
F2761	PCSK9 Antibody [F3K11]
F2760	PCSK9 Antibody [M4L6]
E7998	PD 123319 ditrifluoroacetate	PD 123319 (ditrifluoroacetate) is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.
S7395	PD 150606	PD150606 is a potent and selective inhibitor of calpainwith Ki values of 0.21 µM for µ-calpain and 0.37 µM for m-calpain. It exhibits neuroprotective effects by reducing hypoxic/hypoglycemic injury in cerebrocortical neurons and excitotoxic damage in cerebellar Purkinje cells.
S5183	PD 169316	PD 169316 is a potent, selective and cell-permeable p38 MAP kinase inhibitor with IC50 of 89 nM. PD169316 abrogates signaling initiated by both TGFbeta and Activin A. PD169316 shows antiviral activity against Enterovirus71.
E7751	PD 90780	PD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF, prevents NGF binds with p75NTR. PD 90780 inhibits NGF-p75NTR interaction with IC50s of 23.1 and 1.8 µM in PC12 cells and PC12nnr5 cells, respectively .
S8158	PD-1/PD-L1 Inhibitor 3	PD-1/PD-L1 Inhibitor 3（Programmed Death-1/Programmed Death-Ligand 1 Inhibitor 3）is a Macrocyclic inhibitor of PD-1/PD-L1 interaction with IC50 of 5.6 nM
S8493	PD-166866	PD-166866 is a synthetic molecule inhibiting the tyrosin kinase action of FGFR1, shows a very high selectivity towards FGFR1 and inhibits the auto-phosphorylation activity of FGRF1.
F2853	PD-L1 Antibody [G4H2]	CD274 (PD-L1, B7-H1),PD-L1
F2670	PD-L1 Antibody [P4L19]	CD274 (PD-L1, B7-H1),PD-L1
F4028	PD-L2 Antibody [C11K4]
F0551	PD-L2 Antibody [K17B13]
S8148	PD0166285	PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations (IC50=24 nM for Wee1 and 72 nM for Myt1). PD0166285 is also a novel G2 checkpoint abrogator. PD0166285 induces apoptosis.
S7098	PD123319	PD 123319 is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.
S2168	PD128907 HCl	PD 128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor.
S6956	PD146176	PD146176 (NSC168807) is a potent inhibitor of 15-lipoxygenase (15-LO) with Ki of 197 nM for rabbit reticulocyte 15-LO.
S6546	PD153035	PD153035 is a specific and potent inhibitor of the epidermal growth factor (EGF) receptor tyrosine kinase (Ki = 5.2 pM).
S1079	PD153035 HCl	PD153035 HCl (SU-5271 HCl, AG1517 HCl, ZM 252868 HCl) is a potent and specific inhibitor of EGFR with K_i and IC50 of 5.2 pM and 29 pM in cell-free assays; little effect noted against PGDFR, FGFR, CSF-1, InsR and Src.
E7628	PD158780	PD158780 is a potent EGFR family inhibitor with IC50s of 8 pM, 49, 52, 52 nM for EGFR, ErbB2, ErbB3, and ErbB4, respectively.
S7039	PD168393	PD168393 is an irreversible EGFR inhibitor with IC50 of 0.70 nM, irreversibly alkylate Cys-773; inactive against insulin, PDGFR, FGFR and PKC.
S1264	PD173074	PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM in cell-free assays, ~1000-fold selective for FGFR1 than PDGFR and c-Src. PD173074 reduces proliferation and promotes apoptosis in gastric cancer cells.
E1368	PD173212	PD173212(Compound 11) is a selective N-type voltage sensitive calcium channel (VSCC) blocker, with an IC50 of 36 nM in IMR-32 assays.
S7269	PD173955	PD173955 is a potent Bcr-Abl inhibitor with IC50 of 1-2 nM, also inhibiting Src activity with IC50 of 22 nM.
S0739	PD184161	PD184161, an orally active MEK inhibitor with IC50 of 10-100 nM in a time- and concentration-dependent manner, inhibits cell proliferation and induces apoptosis, and produces depressive-like behavior.
S1020	PD184352 (CI-1040)	PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. PD184352 (CI-1040) selectively induces apoptosis.
S1177	PD98059	PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 μM in a cell-free assay, specifically inhibits MEK-1-mediated activation of MAPK; does not directly inhibit ERK1 or ERK2. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR) and functions as an AHR antagonist.
F0489	PDCD4 Antibody [N11F3]	PDCD4,Pdcd-4
F3297	PDCD4 Antibody [P19F6]	PDCD4,Pdcd-4
F3476	PDCD6/ALG-2 Antibody [D6F22]
S8862	PDD00017273	PDD00017273 is a potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor with an IC50 of 26 nM. PDD00017273 exhibits >350-fold selectivity for PARG over a panel of ion channels, enzymes and receptors, including PARP1 and ARH3.
S0627	PDEC-NB	PDEC-NB is a disulfide cleavable linker that can be applied into the synthesis of antibody-drug conjugates (ADCs).
S8721	PDGFR inhibitor 1	PDGFR inhibitor 1 is an orally bioavailable switch pocket control inhibitor of wild-type and mutated forms of Kit (c-Kit) and PDGFR with potential antineoplastic activity. It also inhibits several other kinases, including VEGFR2, TIE2, PDGFR-beta and CSF1R, thereby further inhibiting tumor cell growth.
F4076	PDGFR α Antibody [E14D18]
F3240	PDGFR α Antibody [P1E17]	PDGF Receptor alpha/PDGFR-α,PDGF Receptor α,PDGFR alpha
F1540	PDGFR α/β Antibody [C19P10]
F3190	PDHB Antibody [B10A22]
F0392	PDHK1 Antibody [J6P24]	PDHK1
F3123	PDI Antibody [C9H24]
F0238	PDI Antibody [M24L14]	P4HB,PDI,Protein Disulfide Isomerase/P4HB
A5698	PDIA6 Rabbit Recombinant mAb	PDIA6 Rabbit Recombinant mAb detects endogenous level of total PDIA6.
F1103	PDK1 Antibody [P9M7]	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, Pyruvate dehydrogenase kinase isoform 1, PDH kinase 1, PDK1, PDHK1, [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial, Pyruvate dehydrogenase kinase isoform 4, PDK4, PDHK4, [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial, Pyruvate dehydrogenase kinase isoform 3, PDK3, PDHK3, [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial, Pyruvate dehydrogenase kinase isoform 2, PDH kinase 2, PDKII, PDK2, PDHK2
F2345	PDK2 Antibody [L2A10]
F2759	PDK4 Antibody [C15G7]
E5843	PDK4-IN-1 hydrochloride	PDK4-IN-1 hydrochloride is an anthraquinone-derived, orally active allosteric inhibitor of PDK4 with an IC50 of 84 nM, exhibiting anticancer activity by regulating cell proliferation, transformation, and apoptosis. It also exhibit antidiabeti and anti-allergic activity.
S0155	PDM-11	PDM-11 is a derivative of resveratrol that exhibits stronger antagonist affinity for arylhydrocarbon receptors (AhR) than resveratrol, without any affinity for the estrogen receptor.
S6560	PDM2	PDM2 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist.
F3890	PDPK1 Antibody [K10G23]
A5665	PDPK1 Rabbit Recombinant mAb	PDPK1 Rabbit Recombinant mAb detects endogenous level of total PDPK1.
E1484	PDS-0330	PDS-0330 is an inhibitor of Claudin-1, which inhibits claudin1-mediated signalling by interfering with its binding to Src. PDS-0330 exhibits an antitumor effect and enhances apoptosis in colorectal cancer cells.
S3633	PDTC (Pyrrolidinedithiocarbamate ammonium)	PDTC (Pyrrolidinedithiocarbamate ammonium) is a potent nuclear factor-κB (NF-κB) inhibitor that inhibits IκB phosphorylation, blocks NF-κB translocation to the nucleus and reduces the expression of downstream cytokines.
F3781	PDX1 Antibody [E2L13]
F0646	Pdx1 Antibody [F18P8]
H2987	PE BCRP1 Antibody [5D3]	Breast cancer resistance protein (BCRP1), also known as placenta-specific ATP-binding cassette (ABC) protein (ABCP) or ABC G-subfamily member 2 (ABCG2), or mitoxantrone resistance protein (MXR), is a member of the ATP-binding cassette superfamily of drug transporters thought to be involved in multi-drug resistance in human neoplastic disease. ABCG2 is expressed in drug-resistant breast, colon and gastric cancer and fibrosarcoma cancer cell lines and in blast cells from patients with acute myeloid leukemia (AML). Normal tissues that express the ABCG2 protein include placental syncytiothrophoblasts, mammary ducts and lobules, epithelium in the large intestine and colon, venous and capillary epithelium and bile canalicular membrane of the live
G0407	PE BrdU Antibody [BU20A]	Bromodeoxyuridine (5-bromo-2-deoxyuridine, BrdU) is a synthetic nucleoside that is an analogue of thymidine. BrdU is commonly used in the detection of proliferating cells in living tissues, and can be incorporated into the newly synthesized DNA of replicating cells (during the S phase of the cell cycle), substituting for thymidine during DNA replication. Antibodies specific for BrdU can then be used to detect the incorporated chemical, thus indicating cells that were actively replicating their DNA. Binding of the antibody requires denaturation of the DNA, usually by exposing the cells to acid or heat.
G4562	PE CCL2/MCP-1 Antibody [2H5]
G0797	PE CD103/Integrin αE Antibody [2E7]	CD103, also known as ITGAE or Integrin alpha E, is a molecule that non-covalently associates with integrin beta 7 to form a heterodimeric integral membrane protein. This protein is part of the integrin family, characterized by an alpha chain and a beta chain. Specifically, CD103 includes a 150 kDa alpha chain and a 120 kDa beta chain, with the alpha integrin undergoing post-translational cleavage in the extracellular domain to yield disulfide-linked heavy and light chains. CD103 is primarily expressed on mucosa-associated T lymphocytes, intraepithelial lymphocytes (IELs), and activated cells, as well as a subset of TGF beta-1 cells. It is preferentially found in human intestinal IELs, where it plays a role in adhesion and may serve as an ac
G3452	PE CD105/Endoglin Antibody [MJ7/18]	CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up-regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation-associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.
G0257	PE CD105/Endoglin Antibody [SN6]	CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.
G4052	PE CD117/c-Kit Antibody [2B8]	KIT (c-KIT), also known as CD117, is a proto-oncogene and a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). KIT was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT together with its ligand regulates growth and activation of a variety of hemopoietic and non-hemopoietic cells. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Recently, deregulation of the KIT receptor TK by the prevalent activation loop mutation D816V has served as a focal point in therapeutic strategies aimed at curbing neoplastic mast cell growth. c-Kit is expressed in hematopoietic stem cells, germ cell
G2072	PE CD11b+CD11c Antibody [OX42]	CD11b (Integrin αM) and CD11c (Integrin αX) are α-chain integrins that belong to the β2 integrin family. They are primarily expressed on myeloid cells, including monocytes, macrophages, dendritic cells, and neutrophils. These integrins play key roles in cell adhesion, migration, phagocytosis, and immune regulation through interactions with ligands such as iC3b, ICAM-1, and fibrinogen. CD11b is highly expressed on monocytes and neutrophils, whereas CD11c is widely used as a marker for dendritic cells.
G0092	PE CD11c Antibody [N418]	CD11, along with CD18, form a heterodimer adhesion molecule. In particular, CD11 is composed of CD11a, CD11b and CD11c. CD11a is a leukocyte marker that is expressed in B and T lymphocytes, macrophages, monocytes, neutrophils, basophils and eosinophils. CD11b is primarily expressed by monocytes, macrophages, natural killer cells, some B and T-cells, and granulocytes. CD11c is expressed in monocytes, macrophages, natural killer cells, some granulocytes and less so in a subset of lymphocytes.
G2972	PE CD122/IL-2Rβ Antibody [TM-β1]	CD122 (Interleukin 2 receptor) is involved in T cell-mediated immune responses, primarily expressed in the hematopoietic system and is present in 3 forms. The low affinity form of CD122 is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from CD122. The protein encoded by the CD122 gene represents the beta subunit and is a type I membrane protein. Diseases associate with CD122 protein dysfunction include oligoarti
G0767	PE CD135/Flt3 Antibody [A2F10]	FLT3 is a tyrosine protein kinase that is a member of the growth factor receptor tyrosine kinase family. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
H0782	PE CD135/Flt3 Antibody [BV10A4H2]
G0827	PE CD140a/PDGFRα Antibody [APA5]	PDGFRA is a cell surface receptor tyrosine kinase which binds members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.
H0332	PE CD161 Antibody [HP-3G10]	CD161, also known as NKR-P1A, is a type II transmembrane lectin-like receptor and member of the killer cell lectin-like receptor (KLR) family. CD161 exists as a homodimer and is prominently expressed on natural killer (NK) and NKT cells, where it is proposed to regulate the function of both cell types. CD161 is also found on T cell subsets, including T regulatory cells (Tregs), memory/effector CD4+ T cells, and CD8+ T cells. Th17 cells have been demonstrated to co-express CD161, as surface IL-17A+ cells are contained within the CD161+ fraction of CD4 T cells, so that CD161 (in combination with CCR6) is often used as a marker for enrichment of Th17 cells.
H3257	PE CD171 Antibody [D8A14]
H1292	PE CD18 Antibody [YFC118.3]	CD18 is an integral membrane glycoprotein of ~95 kDa, also known as the beta 2 chain of the LFA-1 complex. CD18 non-covalently links to CD11a, b, or c molecules to form the heteromeric LFA-1 complex. CD18 acts as the receptor for ICAM-1 and is important for cell adhesion and cell-cell interactions.
H1382	PE CD182/CXCR2 Antibody [E14K7]
G0602	PE CD184/CXCR4 Antibody [2B11]	CXCR4 (Fusin, LESTR, HUMSTR) is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains, and functions as a co-receptor for X4 HIV-1 entry into CD4⁺ cells. CXCR4 has been proved to be the co-receptor for HIV-2's binding to CD4 through envelope glycoprotein gp 120 and promotes Env-mediated fusion of the virus. In other cases, CXCR4 can even function as the only receptor for HIV-2's binding to the CD4 host cells. CXCR4 is the receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. CXCR4 acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced c
G1712	PE CD1d Antibody [1B1]	CD1d is a heavy chain associated with Beta 2 microglobulin on cortical thymocytes. Beta 2 microglobulin independent expression of CD1d has also been demonstrated on human intestinal epithelial cells. CD1d is the sole group 2 member of the CD1 family of major histocompatibility (MHC) like glycoproteins. The CD1d gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1
G2267	PE CD201/EPCR Antibody [B2B15]
G4127	PE CD23 Antibody [B3B4]	CD23 is a 45 kDa glycoprotein that serves as a low-affinity receptor for IgE, playing a crucial role in regulating IgE responses and B cell activation. It is expressed on mature B cells, mantle zone B cells, follicular dendritic cells, and at lower levels on T cells, NK cells, Langerhans cells, and platelets. CD23 expression is upregulated upon B cell activation, and its soluble forms are biologically active, acting as potent mitogenic factors. CD23 is strongly expressed on Epstein-Barr virus (EBV)-transformed B lymphoblasts and is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells. It is also detected in neoplastic cells from cases of B cell chronic lymphocytic leukemia and some centroblastic/centrocytic lym
G0272	PE CD24 Antibody [M1/69]	CD24 is a 35-50 kDa glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed on a variety of cell types, including erythrocytes, thymocytes, peripheral lymphocytes, and cells of the myeloid lineage. It is variably glycosylated, resulting in heterogeneity in molecular mass across different cell lineages, which can affect antibody staining levels on lymphocyte populations. In the context of B-cell development, CD24 is expressed from the pro-B-cell stage in the bone marrow through to mature, surface Ig-positive B cells, with very low or negative expression on plasma cells. It is also present on the majority of B-lineage acute lymphoblastic leukemias, B-cell chronic lymphocytic leukemias (CCLs), and B-cell non-Hodgkin's lymphomas. CD2
H2957	PE CD262/DR5 Antibody [DJR2-4 (7-8)]	DR5 is expressed broadly by normal tissues as well as several tumor cells. DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a recently identified death domain containing receptor for TRAIL, which mediates TRAIL induced apoptosis. DR5 is a member of the TNF-receptor superfamily, and contains an intracellular death domain. DR5 can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by DR5. Two transcript variants encoding different isoforms of DR5 and one non-coding transcript have been found. Overexpression of DR5 induces apoptosis and ac
H3287	PE CD266 Antibody [ITEM-4]
H0167	PE CD27 Antibody [O323]	CD27 (TNFRSF7) is a cell surface homodimer of ≥55 kDa subunits that provides co-stimulatory signaling in support of T cell (TCR) and B cell (BCR) receptors. Compared to CD28, whose TCR co-stimulatory signal can trigger cell proliferation, CD27 signaling promotes cell survival and differentiation to effector/memory stages. CD27 may be shed following interaction with its ligand CD70, which is typically expressed on activated dendritic cells, T cells, and B cells. In B cells, CD27 is a phenotypic marker for memory B cells and has also been included among markers for identifying B regulatory cells (Bregs), which regulate CD4+ T cell proliferation and Foxp3/CTLA-4 expression in Treg cells.
H1337	PE CD273 Antibody [MIH18]
G1097	PE CD278 Antibody [C398.4A]
H0692	PE CD284/TLR4 Antibody [HTA125]	TLR4 is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This receptor is most abundantly expressed in placenta, and in the myelomonocytic subpopulation of leukocytes. Mammalian cells respond to LPS by activating TLR4. TLR4 belongs to the multi-protein complex of the lipopolysaccharide (LPS) receptor, containing CD14, LY96, and TLR4, and is involved in signal transduction events induced by LPS found in most gram-negative bacteria. TLR4 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents and
G0662	PE CD284/TLR4 Antibody [UT41]
G0572	PE CD29/ITG-β1 Antibody [C13M2]	CD29, also known as ITGB1 or Integrin Subunit Beta 1, is a 110 kDa cell surface glycoprotein widely expressed by various cells, including all leukocytes. It forms non-covalently linked heterodimers with at least six different alpha integrins (CD49a-f), creating VLA-1 through VLA-6 complexes, as well as with CD51. These alpha-beta integrin heterodimers mediate a range of cellular responses, including adhesion, trafficking, proliferation, and differentiation. CD29-containing integrins bind to extracellular matrix proteins such as collagen, laminin, fibronectin, and vitronectin. Some integrins also interact with cellular receptors like VCAM-1 and MadCAM-1. CD29 plays a crucial role in immune cell trafficking from blood to tissue, particularly
G0197	PE CD31/PECAM-1 Antibody [390]	CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulatio
G1232	PE CD314/NKG2D Antibody [CX5]
H3602	PE CD324/E-Cadherin Antibody [DECMA-1]	Like the other cadherin family members P and N cadherin, E-cadherin is a transmembrane glycoprotein involved in intercellular adhesion. These proteins share a common basic structure. The extracellular portions of the proteins are largely composed of repeating domains, each with two consensus Ca2+-binding motifs. The cytoplasmic domain interacts with a-, b-, and g-catenins and actinins. These catenins connect E-cadherin with the cytoskeleton. Expression is found in most epidermal cells including melanocytes and kerotinocytes. E-cadherin is localized at the intercellular boundaries of epithelial cells in several tissues, and is thought to play a role in maintenance of tissue integrity. Loss of E-cadherin function has been implicated in the pr
G4097	PE CD326/EpCAM Antibody [G8.8]	Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA), also known as CD326, is a transmembrane glycoprotein expressed in the epithelium with a molecular weight of approximately 40 kDa, which functions as an epithelial cell adhesion molecule. Ep-CAM functions as a homotypic calcium-independent cell adhesion molecule, and has a direct impact on cell cycle, proliferation and metabolism of epithelial cells and fibroblasts due to its ability to rapidly induce the proto-oncogene c-myc and the cell cycle regulating genes cyclin A and E. Ep-CAM mediates Ca2+-independent homotypic interactions. Formation of Ep-CAM-mediated adhesions have a negative regulatory effect on adhesions mediated by classic cadherins, which may have strong
G0122	PE CD34 Antibody [RAM34]	CD34 is a highly glycosylated monomeric with a molecular weight range of 111-115 kDa surface protein that is present on many stem cell populations. CD34 is a stem cell marker although its expression on human hematopoietic stem cells is reversible. CD34 may serve as a surface receptor that undergoes receptor-mediated endocytosis and regulates adhesion, differentiation and proliferation of hematopoietic stem cells and other progenitors. CD34 expression is likely to represent a specific state of hematopoietic development that may have altered adhering properties with expanding and differentiating capabilities in both in vitro and in vivo conditions. CD34 is possibly an adhesion molecule with a putative role for mediating the attachment of stem
G0077	PE CD44 Antibody [IM7]	CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential. CD44 is expressed by hematopoietic, non-hematopoietic cells, epithelial tissu
G0017	PE CD45 Antibody [30-F11]	CD45, also known as Leukocyte Common Antigen (LCA). CD45 is expressed by all hematopoietic cells excluding mature erythrocytes and platelets. The cytoplasmic portion of CD45 has tyrosine phosphatase enzymatic activity and plays an important role in activation of lymphocytes.
G0347	PE CD45.1 Antibody [A20]	CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides t
G0107	PE CD45R/B220 Antibody [RA3-6B2]	CD45R (PTPRC) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. CD45 contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. CD45 is specifically expressed in hematopoietic cells and has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists in multiple isoforms as a result of alternative splicing, and these isoforms di
H1427	PE CD47 Antibody [B6H12]
G3482	PE CD5 Antibody [53-7.3]	CD5 is a 67 kDa human T-lymphocyte single-chain transmembrane glycoprotein. CD5 is present on all mature T-lymphocytes, on most of thymocytes and on many T-cell leukemias and lymphomas. CD5 also reacts with a subpopulation of activated B-cells and may act as a receptor in regulating T-cell proliferation. CD5 is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. CD5 is expressed by many T cell leukemia, lymphomas, and activated T cells. Diseases associated with CD5 dysfunction include thymus cancer and Richter's Syndrome.
G1892	PE CD51/Integrin αV Antibody [RMV-7]	ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8, 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands, the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. The ITGB3 protein product is the in
G0242	PE CD62L/L-Selectin Antibody [MEL-14]	The human CD62L is a 74-95 kDa glycoprotein member of the selectin family of adhesion receptors. L-Selectin is comprised of an aminoterminal C-type lectin binding domain, an epidermal growth factor-like domain, two short consensus repeat (SCR) sequences homologous to those found in complement binding proteins, a short spacer region, a transmembrane region and a short cytoplasmic region. Human CD62L (L-Selectin) is constitutively expressed on all classes of leukocytes including lymphocytes (except a substantial population of memory T cells), monocytes and polymorphonuclear cells.
G0482	PE CD68 Antibody [ED1]	CD68 antibody recognizes the rat ED1 antigen, a heavily glycosylated protein of ~90 -110 kDa, also known as rat CD68. The ED1 antigen is expressed on most macrophages populations, as well as on monocytes and is considered as a pan-macrophage marker in the rat. ED1 is expressed predominantly on the lysosomal membrane and lightly on the cell surface. The expression of ED1 antigen being predominantly cytoplasmic, flow cytometry results are improved by the use of a membrane permeabilization procedure, such as Leucoperm, prior to staining.
G0497	PE CD68 Antibody [FA-11]	CD68 is considered a pan-macrophage marker, predominantly expressed on the intracellular lysosomes of tissue macrophages/monocytes, including Kupffer cells, microglia, histiocytes and osteoclasts, and is expressed to a lesser extent by dendritic cells and peripheral blood granulocytes. CD68 is expressed by many tumor types including some B cell lymphomas, blastic NK lymphomas, melanomas, granulocytic (myeloid) sarcomas, hairy cell leukemias, and renal, urinary and pancreatic tumors, and can be used to demonstrate the presence/localization of macrophages.
G0212	PE CD80/B7-1 Antibody [16-10A1]	CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28, and of an inhibitory receptor CTLA-4 (CD152). Both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, and both molecules can also substitute for each other in this process. CD80 is rapidly induced on the surface of in vitro activated B cells, with Epstein Barr Virus (EBV) transformed B cell lines, with Burkitts lymphoma cell lines, with freshly isolated follicular B lymphoma cells, T cells, and monocytes. The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 and CTLA4 ligands of T cells. Diseases associated with CD80 dysfunct
H1742	PE CD88 Antibody [S5/1]	Mouse anti Human CD88 antibody, recognizes the C5a receptor (C5aR) CD88, which is predominantly expressed on cells of the myeloid lineage. It was raised against a synthetic peptide comprising the N-terminal extracellular domain of the C5aR (met1-Asn31) and has recently been shown to recognise the heptameric peptide (D15DKDTLD21). It has been shown to inhibit the binding of C5a to its receptor.
G0002	PE CD8a Antibody [53-6.7]	CD8 (Cluster of differentiation 8), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, plays an integral role in signal transduction, and T cell differentiation and activation. CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8alpha and CD8beta, where it functions as a co-receptor, along with T cell receptor (TCR), for major histocompatibilty complex class I (MHC-I) molecules; whereas its counterpart, CD4, acts as a co-receptor for MHC-II molecules. CD8 exists on the cell surface, where the CD8alpha chain is essential for binding to MHC-I. CD8 is also expressed on a subset of T cells, NK cells, monocytes and dendritic cells as disulfide-linked homodimers of CD8alpha. Ligation of MH
G0737	PE CD90.1/Thy-1.1 Antibody [HIS51]	CD90 (Thy 1) antigen is a GPI linked glycoprotein member of the Immunoglobulin super family. It is expressed in murine T cells, thymocytes, neural cells, Kupffer's cells and fibroblasts. Thy 1 may play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
G2627	PE CD93 Antibody [AA4.1]	CD93 (also known as AA4.1, C1qRp) is a cell-surface glycoprotein and type I membrane protein originally identified as a myeloid cell marker. Although previously considered a C1q receptor, CD93 is now recognized for its roles in intercellular adhesion and the clearance of apoptotic cells. Its intracellular tail interacts with moesin, linking CD93 to the cytoskeleton and cytoskeletal remodeling.
G4922	PE CXCR4 Antibody [UMB2]
G2177	PE DYKDDDDK Tag Antibody [L5]	The DYKDDDDK tag is often used as a protein modification in order to simplify the labeling and detection of proteins.This unique amino acid sequence allows for specific antibody detection in western blotting, immunoprecipitation, and immunostaining techniques.Due to the short sequence, this modification is not likely to affect the structure or function of the modified proteins.
G0062	PE F4/80 Antibody [BM8]
H0767	PE FCER1A Antibody [AER-37 (CRA1)]	Fc epsilon RI alpha, also known as FcεRIα, is a subunit of the high-affinity receptor for IgE, primarily expressed on mast cells and basophils. Its expression is upregulated by the presence of IgE. FcεRIα forms a tetrameric complex with one beta and two gamma subunits, which are essential for signal transduction. The beta and gamma subunits contain immunoreceptor tyrosine-based activation motifs (ITAMs). The FcεRI complex plays a crucial role in triggering IgE-mediated allergic reactions. When allergen-bound IgE molecules bring together two or more high-affinity IgE receptors, it leads to the release of mediators such as histamine, which are responsible for allergy symptoms. This process couples allergens and mast cells to initiate inflamma
G0752	PE FCER1A Antibody [MAR-1]	Fc epsilon RI alpha, also known as FceR1 alpha, is a subunit of the high-affinity receptor for IgE, primarily expressed on mast cells and basophils. Its expression is upregulated by the presence of IgE. Fc epsilon RI alpha forms a tetrameric complex with one beta and two gamma subunits, which are essential for signal transduction. The beta and gamma subunits contain immunoreceptor tyrosine-based activation motifs (ITAMs). The Fc epsilon RI complex plays a crucial role in triggering IgE-mediated allergic reactions. When allergen-bound IgE molecules bring together two or more high-affinity IgE receptors, it leads to the release of mediators such as histamine, which are responsible for allergy symptoms. This process couples allergens and mast
G0047	PE FOXP3 Antibody [PCH101]	FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-alle
G0722	PE Gata-3 Antibody [TWAJ]
H0392	PE Granzyme B Antibody [GB11]	Granzyme B is a member of the granzyme serine protease family, and is found in the granules of cytotoxic T cells and NK cells. Granzyme B has been described as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation, and CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells. Granzyme B is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. The receptor involved in this process has been identified as mannose 6-phosphate receptor which functions as a death receptor for Granzyme B during cytotoxic T cell-induced ap
G1817	PE Helios Antibody [22F6]
G3737	PE HER2/ErbB2 Antibody [H24A7]	The ErbB2 (HER2) proto-oncogene encodes a 185 kDa transmembrane, receptor-like glycoprotein with intrinsic tyrosine kinase activity. While ErbB2 lacks an identified ligand, ErbB2 kinase activity can be activated in the absence of a ligand when overexpressed and through heteromeric associations with other ErbB family members. Amplification of the ErbB2 gene and overexpression of its product are detected in almost 40% of human breast cancers. Binding of the c-Cbl ubiquitin ligase to ErbB2 at Tyr1112 leads to ErbB2 poly-ubiquitination and enhances degradation of this kinase. ErbB2 is a key therapeutic target in the treatment of breast cancer and other carcinomas and targeting the regulation of ErbB2 degradation by the c-Cbl-regulated proteolyt
H2747	PE HLA-G Antibody [87G]
H2762	PE Human B7-H4 Antibody [MIH43]
H1457	PE Human CD10 Antibody [HI10a]	CD10, also known as Neutral Endopeptidase (NEP), Enkephalinase, Atriopeptidase, and Neprilysin, is a 100 kDa type II transmembrane glycoprotein encoded by the MME (membrane metallo-endopeptidase) gene. CD10 has neutral endopeptidase activity and is also referred to as the Common Acute Lymphoblastic Leukemia Antigen (CALLA). It is expressed on a wide variety of normal and neoplastic cell types, including granulocytes, bone marrow stromal cells, a subset of B-cell progenitors, germinal center B cells, and fibroblasts. CD10 is a cell surface metalloendopeptidase that inactivates several signaling molecules, playing a significant regulatory role in the nervous, immune, and other systems.
H0827	PE Human CD103/Integrin αE Antibody [Ber-ACT8]	CD103 is a type I transmembrane glycoprotein also known as αE integrin, integrin αIEL chain, and human mucosal lymphocyte antigen 1. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. Treg cells express high level of CD103. Hairy cell leukemia has also been shown to express CD103. The expression of CD103 on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as an αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD
H0452	PE Human CD107a Antibody [H4A3]	CD107a, also known as Lysosomal-associated membrane protein 1 (LAMP-1), is a ~110 kDa type I transmembrane protein that is heavily glycosylated and widely expressed by cells primarily on the luminal surface of their lysosomes. It is also expressed on the surface of activated platelets, activated lymphocytes, cytotoxic T cells and NK cells, and some tumor cell lines, including U937 and KG1a. LAMP-1 can serve as a ligand for E-selectin-mediated cell adhesion. LAMP-1 and LAMP-2 (CD107b) are carriers for poly-N-acetyllactosamines and are able to display sialyl Le[x] termini.
H0377	PE Human CD117 Antibody [104D2]	CD117 is a 145 kD protein tyrosine kinase also known as c-Kit. It is a receptor for stem cell factor or c-Kit ligand. CD117 is expressed on pluripotent hematopoietic progenitor cells (approximately 1-4% bone marrow cells), mast cells, and acute myeloid leukemia cells (AML). CD117 binding of c-Kit ligand induces phosphorylation of CD117 and stimulates proliferation and survival of primitive hematopoietic stem cells as well as erythroid-committed and granulo-monocytic committed cells.
H3317	PE Human CD11a Antibody [HI111]	This antibody specifically binds to CD11a, the 180 kDa integrin α chain. This type I transmembrane glycoprotein associates with CD18 (integrin β2) to form the heterodimeric glycoprotein CD11a/CD18. This heterodimer is also known as the lymphocyte (leukocytes) function associated antigen-1 (LFA-1) that is expressed on all leukocytes. LFA-1 is an adhesion molecule involved in lymphocyte and granulocyte functions. LFA-1 mediates adhesion of lymphoid cells to the vascular endothelium in association with its ligand, and the intracellular adhesion molecule-1 (ICAM-1), CD54. Other ligands are ICAM-2 (CD102) and ICAM-3 (CD50). Purified Mouse Anti-Human CD11a antibody also cross reacts with all leukocytes of baboon, and both rhesus and cynomolgus ma
H0077	PE Human CD11b Antibody [CBRM1/5]	CD11b, a 165-170 kDa type I transmembrane glycoprotein also known as αM integrin, Mac-1, CR3, and C3biR. CD11b non-covalently associates with integrin β2 (CD18) and is expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b/CD18 is critical for the transendothelial migration of monocytes and neutrophils as well as adhesion, phagocytosis, and neutrophil activation. CD11b/CD18 interacts with ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4, CD14, CD23, heparin, iC3b, fibrinogen and factor X.
H0062	PE Human CD11b Antibody [ICRF44]	CD11b is a 165-170 kD type I transmembrane glycoprotein also known as αM integrin, Mac-1, CR3, and C3biR. CD11b non-covalently associates with integrin β2 (CD18) and is expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b/CD18 is critical for the transendothelial migration of monocytes and neutrophils. It is also involved in granulocyte adhesion, phagocytosis, and neutrophil activation. CD11b/CD18 interacts with ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4, CD14, CD23, heparin, iC3b, fibrinogen, and factor X.
H0137	PE Human CD11c Antibody [3.9]	CD11c is a 145–150 kDa type I transmembrane glycoprotein also known as integrin αx and CR4. CD11c non-covalently associates with integrin β2 (CD18) and is expressed on monocytes/macrophages, dendritic cells, granulocytes, NK cells, and subsets of T and B cells. CD11c has been reported to play a role in adhesion and CTL killing through its interactions with fibrinogen, CD54, and iC3b.
H0482	PE Human CD127 Antibody [HIL-7R-M21]	CD127 is a 60–90 kDa glycoprotein, also known as the IL-7 receptor alpha (IL-7Rα) subunit. The IL-7 receptor complex is a heterodimer composed of CD127 and the common gamma chain (γc, CD132), shared by other cytokine receptors (IL-2R, IL-4R, IL-9R, IL-15R, and IL-21R). CD127 is expressed on thymocytes, T- and B-cell progenitors, mature T cells, and some lymphoid and myeloid cells. In vitro experiments show the expression of CD127 is down-regulated following T cell activation. Studies indicate that the IL-7 receptor plays an important role in the proliferation and differentiation of mature T cells. Recently, it has been shown that low surface expression of CD127, in combination with intermediate to high surface expression of CD25, the α chai
H3332	PE Human CD13 Antibody [WM15]	CD13, also known as aminopeptidase N, is a 150 kDa type II integral membrane glycoprotein. It serves as the cellular receptor for human coronavirus 229E, which can cause upper respiratory tract infections. CD13 is expressed on GM-progenitor cells, granulocytic and monocytic cells, and mast cells, but is absent on lymphocytes, platelets, and erythrocytes. It plays a role in the metabolism of various regulatory peptides.
H3797	PE Human CD137 Antibody [4B4-1]	CD137 is a 39 kD transmembrane protein also known as 4-1BB. It is expressed on activated T cells. CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily. CD137 appears to be important for T cell proliferation and survival, and induces monocyte activation through its interaction with 4-1BB ligand.
H0812	PE Human CD138 Antibody [44F9]
H0182	PE Human CD14 Antibody [M5E2]	CD14 is a 53–55 kDa glycosylphosphatidylinositol (GPI)-anchored single-chain glycoprotein expressed at high levels on monocytes, macrophages, and neutrophils. CD14 is a multifunctional receptor and is constitutively expressed on the surface of mature monocytes and macrophages. It serves as a high-affinity receptor for lipopolysaccharide (LPS) and binds LPS in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute-phase serum protein. CD14 also exists in a soluble form (sCD14) and is released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. The soluble sCD14 is important for neutralizing allochthonous lipopolysaccharides by reconstituted lipoprotein particles and can discriminate structural dif
H0842	PE Human CD140a/PDGFRα Antibody [16A1]
H4052	PE Human CD140b Antibody [18A2]
H4427	PE Human CD140b Antibody [28D4]
H1682	PE Human CD144/VE-cadherin Antibody [55-7H1]	Cadherin-5, a member of the cadherin family of calcium-dependent adhesion molecules, is also known as CD144 or VE-Cadherin. CD144 is expressed on endothelial cells in vivo and in vitro. It may play a role in the organization of lateral endothelial junctions and in the control of permeability properties of vascular endothelium.
H1037	PE Human CD146 Antibody [P1H12]	CD146, also known as MCAM, MUC18, or Mel-CAM, is a 118 kDa transmembrane glycoprotein and a member of the immunoglobulin superfamily. It is strongly expressed by blood vessel endothelium and smooth muscle. CD146 is also found on angioblasts, mesenchymal stem cells, melanoma cells, intermediate trophoblasts, and a subset of activated T cells. CD146 is widely used as a marker for endothelial cells and plays a key role in studies of angiogenesis, cancer progression, and vascular biology.
H1352	PE Human CD152/CTLA-4 Antibody [BNI3]	CD152, also known as CTLA-4 (Cytolytic T Lymphocyte-Associated Antigen 4), is a molecule transiently expressed on activated CD28+ T cells. It binds to CD80 and CD86 on antigen-presenting cells (APCs) with high avidity, delivering a negative regulatory signal to the T cell. It has also been shown that CTLA-4 is expressed on B cells when cultured with activated T cells, indicating a role in regulating the B-cell response. Additionally, CD152 is expressed on regulatory T (Treg) cells. The BNI3 monoclonal antibody specifically binds to human CTLA-4 and can be used to study its role in T-cell proliferation and regulation.
H1367	PE Human CD155/PVR Antibody [SKII.4]
H1127	PE Human CD16 Antibody [3G8]	CD16a is a ~50–65 kDa type I transmembrane glycoprotein encoded by FCGR3A (Fc fragment of IgG receptor IIIa), which belongs to the immunoglobulin superfamily. CD16a is also known as Fc-gamma RIII-alpha (FcγRIIIA or FcRIIIa) and is expressed on natural killer (NK) cells, activated monocytes, macrophages, γδ T cells, immature thymocytes, and mast cells. CD16a binds immune-complexed or aggregated IgG and associates with CD247/TCRζ in NK cells and FcεRIγ chains in phagocytes and mast cells to transduce intracellular signals. CD16a functions in antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses including phagocytosis, cytokine production, or mediator release. CD16b is a ~48 kDa glycophosphatidylinositol (GPI)-
H3497	PE Human CD163 Antibody [GHI/61]	CD163 is also known as Scavenger receptor cysteine-rich type 1 protein M130 (M130), Hemoglobin scavenger receptor and Macrophage-associated antigen. CD163 is a 110-130 kDa transmembrane glycoprotein. CD163 is a monocyte/macrophage-restricted antigen expressed on the majority of tissue macrophages and peripheral blood monocytes. CD163 belongs to the scavenger receptor superfamily. Its expression on monocytes is upregulated upon cellular activation. CD163 expression reportedly changes on monocytes and macrophages as these cells differentiate. This finding suggests a role for this molecule in the differentiation and/or regulation of monocyte and macrophage function. CD163 may play a role in the clearance and endocytosis of hemoglobin and hapto
H2822	PE Human CD166/ALCAM Antibody [3A6]	CD166, also known as Activated Leukocyte Cell Adhesion Molecule (ALCAM) and the CD6 ligand, is a 100–105 kDa transmembrane glycoprotein belonging to the immunoglobulin superfamily. It consists of an immunoglobulin-like extracellular domain, a transmembrane region, and a short cytoplasmic tail. CD166 is expressed on neurons, activated T cells, activated monocytes, epithelial cells, and fibroblasts. It plays a key role in mediating adhesion interactions, particularly between thymic epithelial cells and CD6+ cells during intrathymic T-cell development.
H0947	PE Human CD169 Antibody [7-239]
H2102	PE Human CD172a/b Antibody [SE5A5]
H2792	PE Human CD178 Antibody [NOK-1]	Fas (APO-1, CD95) is a 45 kD cell surface protein that mediates apoptosis when crosslinked with agonistic anti-Fas antibodies or Fas ligand (FasL). Fas belongs to the TNF (tumor necrosis factor)/NGF (nerve growth factor) receptor family, and is expressed in various tissue and cells including the thymus, liver, ovary and lung. FasL is a member of the TNF cytokine family that induces apoptosis by binding to Fas, its cell-surface receptor. FasL may exist in both membrane and soluble forms and expressed on activated T cells, NK cells, and other “immunologically privileged” sites. Both Fas and FasL are thought to play an important role in the apoptotic processes that take place during T cell development. This antibody recognizes human FasL. It r
H1562	PE Human CD186/CXCR6 Antibody [56811]
H0002	PE Human CD19 Antibody [HIB19]	CD19 is a 95 kDa type I transmembrane glycoprotein expressed during all stages of B-cell maturation and differentiation, except on plasma cells. It is also present on follicular dendritic cells but not found on T cells or normal granulocytes. CD19 functions as a signal transduction molecule that regulates B cell development, activation, proliferation, and differentiation. It associates with complement receptor 2 (CD21), TAPA-1 (CD81), Leu 13, and/or MHC class II to form a signal transduction complex on the surface of B cells.
H0017	PE Human CD19 Antibody [LT19]	CD19 is a type I transmembrane glycoprotein of 95 kDa that belongs to the immunglobulin superfamily. CD19 is expressed on B cells throughout most stages of B cell differentiation, though its expression is down-regulated during their terminal differentiation to plasma cells. Expression of CD19 is also found in the majority of B cell–derived malignancies. CD19 is further present on follicular dendritic cells. On B cells, CD19 associates with CD21, CD81, and CD225 (Leu-13) forming a signal transduction complex.
H1577	PE Human CD1a Antibody [HI149]	CD1a is a type I transmembrane glycoprotein. The 49 kDa CD1a polypeptide is associated with β2-microglobulin. CD1a is expressed on cortical thymocytes, dendritic cells and Langerhans cells. CD1a has structural similarities to the MHC class I antigen, and plays a role in antigen presentation.
H1592	PE Human CD1c Antibody [L161]	CD1c, also known as R7 or M241, is a 43 kD member of the five CD1 antigens (CD1a-e) in humans. The CD1 molecules are type I glycoprotein with structural similarities to MHC class I and are non-covalently associated with β2-microglobulin, belonging to the Ig superfamily. CD1c is expressed on cortical thymocytes, Langerhans cells, dendritic cells, and a subset of B cells. It has been reported that CD1c is also expressed on mature T cells in a tightly regulated manner. CD1c is involved in antigen-presentation of glycolipids. It may also act in T cells as an immune regulatory molecule.
H1157	PE Human CD20 Antibody [2H7]	CD20 is a 33-37 kD, four transmembrane spanning protein, also known as B1 and Bp35. CD20 is expressed on pre-B-cells, resting and activated B cells (not plasma cells), some follicular dendritic cells, and at low levels on a T cell subset. CD20 is heavily phosphorylated on activated B cells and malignant B cells. Homo-oligomeric complexes of CD20 are thought to form Ca2+ conductive ion channels in the plasma membrane of B cells. The CD20 molecule is involved in B-cell activation and is associated with various Src family kinases (Lyn, Lck, Fyn). It exists in a complex with MHC class I and II, CD53, CD81, and CD82.
H2777	PE Human CD201/EPCR Antibody [RCR-401]
H2297	PE Human CD21 Antibody [B-ly4]
H1052	PE Human CD235a Antibody [GA-R2 (HIR2)]	CD235a is also known as Glycophorin A (GYPA, GPA, GLPA), Sialoglycoprotein alpha, MN sialoglycoprotein, or PAS-2. CD235b is also known as Glycophorin B (GYPB, GPB, GLPB), Sialoglycoprotein delta, SS-active sialoglycoprotein, or PAS-3. CD235a and CD235b are type I transmembrane sialoglycoproteins expressed on human erythrocytes, erythroid precursor cells, and certain leukemic cell types. CD235a carries blood group M and N antigens, whereas CD235b contains S, s, and U antigens. Glycophorins may play a role in preventing cell agglutination. The antibody against CD235a/b is useful for the identification and characterization of erythrocytes, certain myeloid leukemic cell types, and for studies of erythroid development and infectious diseases inv
H0317	PE Human CD24 Antibody [ML5]	CD24, also known as CD24A, signal transducer CD24, small cell lung carcinoma cluster 4 antigen, or BA-1, is a 35-70 kDa glycophosphatidylinositol (GPI)-linked glycoprotein. Its glycosylation pattern is highly variable and cell-type dependent. CD24 is expressed on neutrophils, eosinophils, dendritic cells, neural cells, epithelial cells, muscle cells, and many types of cancer cells. CD24 functions as an adhesion receptor. Several different ligands have been identified for CD24, including CD62P (P-selectin), which is expressed on activated platelets and activated endothelium. CD24 is variably expressed on all B lineage cells, except plasma cells, and can play a role in regulating the activation, proliferation, or differentiation of these cell
H4247	PE Human CD25 Antibody [M-A251]	The CD25 antigen is also known as the human low-affinity interleukin-2 receptor α chain (IL-2Rα) and the Tac antigen. The CD25antigen is present on a subset of peripheral blood lymphocytes. Antigen density increases on phytohemagglutinin (PHA)-, concanavalin A (Con A)-, and CD3-activated T lymphocytes; T lymphocytes from mixed lymphocyte cultures; and HTLV-infected T-lymphocyte leukemia lines, for example, HUT-102. Recombinant IL-2 blocks the binding of CD25 to PHA-activated T lymphocytes. CD4+/CD25+ regulatory T cells might directly regulate the function of responsive T cells. The CD25antibody is composed of mouse IgG1 heavy chains and kappa light chains
H2162	PE Human CD268/BAFF-R Antibody [11C1]
H4112	PE Human CD271/NGFR Antibody [ME20.4]	CD271, also known as p75NTR, TNFRSF16, p75(NTR), Gp80-LNGFR, and NGFR, is a type I transmembrane protein with a MW of 75 kD. It is expressed by many cell types including neurons, Schwann cells, mesenchymal stem/stromal cells, follicular dendritic cells and melanocytes. The extracellular portion contains four TNFR-Cys repeats that form the binding domain for its ligands (NGF, BDNF, NTF3, and NTF4). The intracellular portion of CD271 contains a death domain, which interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9, to promote cell apoptosis, and to regulate cell differentiation and neurogenesis.
H1712	PE Human CD276/B7-H3 Antibody [DCN.70]
H0437	PE Human CD279/PD-1 Antibody [EH12.2H7]	Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC) are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.
H4097	PE Human CD28 Antibody [CD28.2]	CD28 is a 44 kDa homodimeric transmembrane glycoprotein expressed on most mature T cells, thymocytes, and plasma cells. It acts as a costimulatory receptor, binding to CD80 and CD86 ligands, and plays a crucial role in T cell-B cell interactions. CD28 is believed to initiate and regulate a distinct signal transduction pathway that is separate from those stimulated by the TCR complex. The binding of CD28 to its ligands can also influence immune responses, including the production of IL-2 and changes in intracellular calcium concentrations.
H0617	PE Human CD29/ITG-β1 Antibody [MAR4]	CD29 is a 130 kDa integrin β1 subunit that is expressed as a heterodimeric complex with one of six distinct α subunits, comprising the very late activation antigen (VLA) subfamily of adhesion receptors. The β1 subunit has a broad tissue distribution; it is expressed on lymphocytes, monocytes and weakly on granulocytes, but not on erythrocytes. These receptors are involved in a variety of cell-cell and cell-matrix interactions.
H1757	PE Human CD294/CRTH2 Antibody [BM16]	CD294, also known as CRTH2, is a seven-transmembrane protein coupled with heterotrimeric G proteins. CRTH2 is the prostaglandin D2 receptor and is expressed by Th2 cells, eosinophils, and basophils. CD294 prevents the apoptosis of Th2 cells and mediates the chemotaxis of CRTH2 expressing cells to the sites of allergic inflammation, such as the asthmatic lung.
H4277	PE Human CD3 Antibody [OKT-3]	CD3ε is one of five polypeptide chains that combine to form the TCR complex. CD3ε is expressed on T lymphocytes, NK-T cels, and to varying degrees on developing thymocytes. CD3 plays roles in TCR signaling, T lymphocyte activation, and antigen recognition.
H4352	PE human CD3 Antibody [UCHT1]
H0242	PE Human CD31 Antibody [AC128]
H0227	PE Human CD31 Antibody [WM59]	CD31 (PECAM-1), also known as GPIIA' or EndoCAM, is a 130 kDa type I transmembrane glycoprotein belonging to the Ig gene superfamily. It is widely expressed on platelets, monocytes, granulocytes, NK cells, T cell subsets, and in high amounts on endothelial cells. CD31 functions as a vascular endothelial cell adhesion molecule, playing a critical role in the transendothelial migration of leukocytes during inflammatory responses. It is also involved in thrombosis, angiogenesis, and wound healing. The antibody against PECAM-1 binds to an epitope near extracellular domain 2 of CD31. Clone WM59 also cross-reacts with peripheral blood platelets and leukocytes of baboon, and both rhesus and cynomolgus macaque monkeys. The staining intensity of WM5
H1397	PE Human CD314/NKG2D Antibody [1D11]	CD314, also known as NKG2D or KLRK1, is a 42 kDa type II transmembrane glycoprotein and a member of the C-type lectin family. It is expressed on human NK cells, as well as on virtually all TCR γ/δ+ and CD8+ TCR α/β+ T cells. NKG2D functions as an activating receptor that binds strongly to several ligands, including MICA, MICB, and ULBP-1, -2, and -3, which are expressed by different target cell types. Unlike other natural cytotoxicity receptors (NCR), NKG2D is not restricted to NK cells. It plays a critical role in natural cytotoxicity, aiding normal NK cells in attacking a variety of tumor or normal target cells. NKG2D can complement the role of NCR in tumor cell lysis, and combined masking of both NCR and NKG2D can lead to a complete inhi
H3197	PE Human CD325/N-Cadherin Antibody [8C11]
H2462	PE Human CD328/Siglec-7 Antibody [6-434]
H0917	PE Human CD33 Antibody [WM53]	CD33, also known as Sialic acid-binding Ig-like lectin 3 (Siglec-3), gp67, or p67, is a 67 kDa type I transmembrane glycoprotein expressed on monocytes, activated T cells, myeloid progenitors, and mast cells. CD33 is absent on normal platelets, lymphocytes, erythrocytes, and hematopoietic stem cells. This glycoprotein can reportedly function as a sialic acid-dependent cell adhesion molecule. This function can be modulated by endogenous sialoglycoconjugates when CD33 is expressed on the membrane.
H1067	PE Human CD36 Antibody [CB38 (NL07)]
H3647	PE Human CD366 Antibody [F38-2E2]
H0857	PE Human CD38 Antibody [HIT2]	The CD38 antigen is also known as T10, ADP-ribosyl cyclase 1, and cyclic ADP ribose hydrolase 1. CD38 is a 45 kDa type II single-chain transmembrane glycoprotein present on thymocytes, activated T cells, and terminally differentiated B cells (plasma cells). It is also expressed by monocytes, macrophages, dendritic cells, NK cells, myeloid and erythroid precursors, and some epithelial cells. CD38 functions as an ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose, a Ca²⁺-mobilizing second messenger. This intracellular calcium plays an important role in cell signaling pathways leading to cellular growth, apoptosis, and differentiation. CD38 binds to CD31, contributing to lymphocyte adhesion to endothelial cells.
H3377	PE Human CD39 Antibody [A1]	CD39 is an integral membrane protein with two transmembrane domains in humans. It exists as a homotetramer. Expression of CD39 is found on activated lymphocytes, a subset of T cells and B cells, and dendritic cells with weak staining on monocytes and granulocytes. CD39 and CD73 have been found on regulatory T cells, specifically the effector/memory like T cells. CD39 can hydrolyze both nucleoside triphosphates and diphosphates. CD39 is the dominant ecto nucleotidase of vascular and placental trophoblastic tissues and appears to modulate the functional expression of type 2 purinergic (P2) G protein coupled receptors (GPCRs). CD39 has intrinsic ecto-ATPase activity. Expression of CD39 is induced on T cells and increased on B cells as a late a
H0047	PE Human CD4 Antibody [L200]	CD4 is a 56 kDa transmembrane glycoprotein expressed on the T-helper/inducer subset of peripheral blood lymphocytes in humans. It is primarily found on CD3-positive, CD8-negative T cells and does not react with B- or NK-cell markers. In baboons, CD4 is expressed on lymphocytes and weakly on monocytes. The distribution of CD4 on lymphocytes is similar between humans and these non-human primates.
H0032	PE Human CD4 Antibody [RPA-T4]	CD4 is a 56 kDa transmembrane glycoprotein expressed on the T-helper/inducer subset of normal human peripheral blood lymphocytes. The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex
H0557	PE Human CD40 Antibody [5C3]	CD40 is a 45–48 kDa type I transmembrane glycoprotein primarily expressed on B lymphocytes, though it is absent on terminally differentiated B cells. It is also found on endothelial cells, basal epithelial cells, certain epithelial cell carcinomas, follicular dendritic cells, macrophages, fibroblasts, keratinocytes, and CD34+ hematopoietic progenitor cells. CD40 plays a critical role in B-cell growth, proliferation, and differentiation, including immunoglobulin isotype switching. Engagement of CD40, particularly in the presence of IL-4 or costimulation with anti-µ or anti-CD20 antibodies, can promote B-cell proliferation.
H0887	PE Human CD41a Antibody [HIP8]	CD41a, also known as Integrin αIIb or Platelet GPIIb, forms a calcium-dependent complex with CD61 (β3 integrin or GPIIIa) that is normally expressed on platelets and megakaryocytes. The CD41/CD61 complex serves as a receptor for fibrinogen, fibronectin, and von Willebrand factor, mediating platelet adhesion and aggregation. Blocking CD41 can completely inhibit ADP-, epinephrine-, and collagen-induced platelet activation, and partially inhibit ristocetin- and thrombin-induced activation.
H4037	PE Human CD42b Antibody [HIP1]	CD42b is also known as the Platelet glycoprotein Ib alpha chain that is encoded by the GP1BA gene. CD42b is disulfide bonded to CD42c to form a 170 kDa heterodimer, GPIb. GPIb forms a noncovalent complex with CD42a and CD42d (CD42 complex) that is expressed on platelets and megakaryocytes. The CD42 complex serves as the von Willebrand Factor (vWF) surface receptor involved in the adhesion of platelets to the subendothelium of damaged vascular walls. This antibody inhibits the ristocetin-dependent binding of vWF to platelets and partially inhibits collagen-induced aggregation.
H0107	PE Human CD45 Antibody [5B1]
H0092	PE Human CD45 Antibody [HI30]	CD45 is encoded by the PTPRC (Protein tyrosine phosphatase receptor type C) gene. CD45, also known as the leukocyte common antigen (LCA), is a member of the protein tyrosine phosphatase (PTP) family. It is present on all human leukocytes including lymphocytes, monocytes, granulocytes, eosinophils, and thymocytes. CD45 is absent from circulating erythrocytes, platelets, or mature erythroid cells of bone marrow and non-hemopoietic tissues.
H0737	PE Human CD45RA Antibody [HI100]	CD45RA, a 220 kDa isoform of the human leukocyte common antigen, is expressed on approximately 40–50% of peripheral CD4+ T cells, 50% of peripheral CD8+ T cells, and on a portion of B cells and monocytes. The CD45RA antigen is expressed by naïve and activated T cells. CD45RA-specific antibodies are useful for the study of the suppressor/inducer subpopulation of CD4+ lymphocytes.
H4007	PE Human CD45RO Antibody [UCHL1]	CD45RO is a 180 kDa isoform of the CD45 molecule, also known as the Leukocyte Common Antigen. It is a type I transmembrane glycoprotein with cytoplasmic protein tyrosine phosphatase activity involved in signal transduction. Unlike other CD45 isoforms, CD45RO lacks the amino acid sequences encoded by the variable exons A, B, and C. It is expressed on most thymocytes, activated T cells, memory T cells, granulocytes, and monocytes, and on a subset of resting T cells. CD45RO and CD45RA mark largely distinct populations within resting peripheral T cells, demonstrating functional and phenotypic heterogeneity within CD4 and CD8 T cell subsets. CD45RO also interacts with CD22.
H0527	PE Human CD49f Antibody [GoH3]	CD49f, also known as the integrin α6 chain, is a ~150 kDa type I transmembrane glycoprotein that belongs to the integrin alpha chain family of extracellular matrix and cell adhesion receptors. The integrin α6 subunit associates with the integrin β1 chain (CD29) to form VLA-6, and with the integrin β4 chain (CD104) to form the integrin α6β4 complex, also known as the laminin and kalinin receptor. CD49f is expressed mainly on T cells, monocytes, platelets, epithelial cells, endothelial cells, perineural cells, and trophoblasts of the placenta. Antibodies against CD49f can block the binding of integrin α6 to laminin P1 and E8 fragments.
H3977	PE Human CD5 Antibody [UCHT2]	CD5, also known as Leu-1, Ly-1 and T1, is a 67 kD single chain type I glycoprotein that is a member of the scavenger receptor superfamily. CD5 is expressed on T cells, thymocytes, B cell subsets, chronic B lymphocytic leukemia (B-CLL), and peripheral blood dendritic cells. CD5 modulates T and B cell receptor signaling, thymocyte maturation, and T-B cell interactions. One of its ligands is CD72.
H2192	PE Human CD51 Antibody [NKI-M9]
H1247	PE Human CD54 Antibody [HA58]	CD54, also known as Intercellular Adhesion Molecule 1 (ICAM-1), is an 85-110 kDa type I transmembrane glycoprotein that belongs to the immunoglobulin supergene family. A soluble form of CD54 can also be found in biological fluids. CD54 is expressed on endothelial cells, as well as on both resting (weak) and activated (moderate) lymphocytes and monocytes. It serves as a ligand for LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). The CD54 adhesion molecule plays a key role in inflammatory and immune responses, as well as in neoplasia.
H4262	PE Human CD56/NCAM-1 Antibody [B159]	CD56 is a heavily glycosylated adhesion protein that is present on a subpopulation of peripheral blood large granular lymphocytes that demonstrate natural killer activity. CD56 is also expressed on a subset of T cells but is not expressed on myeloid cells, erythrocytes or B cells. This antigen is a pan-NK-cell marker. CD56 is virtually identical to an isoform of the neural cell adhesion molecule (NCAM), a structure mediating homotypic and heterotypic cell-cell interactions.
H3962	PE Human CD61 Antibody [VI-PL2]	CD61 is a 105 kDa transmembrane glycoprotein that is also known as integrin β3 and platelet glycoprotein IIIa (GPIIIa or GP3A). It is expressed on platelets, megakaryocytes, osteoclasts and endothelia. Integrin β3 associates with gpIIa (CD41) to form the CD41/CD61 complex which mediates platelet adhesion and aggregation. CD61 also associates with CD51 to form the CD51/CD61 complex (vitronectin receptor). CD61 appears to bind to fibrinogen, fibronectin, vWF, vitronectin, and thrombospondin to mediate cell adhesion.
H0287	PE Human CD62L Antibody [DREG-56]	CD62L (L-selectin) is a cell surface glycoprotein expressed on neutrophils, monocytes, T- and B-lymphocyte subsets, and NK cells. CD62L functions as a lymphocyte homing receptor, playing a key role in the migration of lymphocytes to peripheral lymph nodes via high endothelial venules (HEV).
H1322	PE Human CD63 Antibody [H5C6]	CD63 is a 53 kDa, type III lysosomal glycoprotein that belongs to the tetraspan transmembrane 4 superfamily (TM4SF). It is expressed on activated platelets, monocytes, and macrophages, and is also known by several other names, including LIMP, gp55, melanoma-associated antigen ME491, Pltgp40, and LAMP-3. CD63 is widely expressed on the surface and in the cytoplasm of various hematopoietic cells (such as monocytes and macrophages) as well as non-hematopoietic cells (including endothelium, fibroblasts, osteoclasts, and smooth muscle cells). It plays a key role in mediating cellular adhesion and motility.
H0512	PE Human CD68 Antibody [Y1/82A]	CD68, also known as Scavenger receptor class D member 1 (SCARD1), Macrosialin, or GP110, is a 110 kDa type I transmembrane glycoprotein primarily localized in cytoplasmic granules of monocytes, macrophages, dendritic cells, granulocytes, myeloid progenitor cells, and reportedly, a subset of CD34-positive hematopoietic bone marrow progenitor cells. CD68 belongs to the sialomucin family and functions as a scavenger receptor, capable of binding and internalizing oxidized low-density lipoproteins (LDL). Antibodies targeting CD68 are commonly used in studies of myeloid cell development and function.
H3992	PE Human CD7 Antibody [M-T701]
H1877	PE Human CD70 Antibody [113-16]
H3932	PE Human CD71 Antibody [M-A712]	This antibody specifically binds to CD71 which is also known as the transferrin receptor (TFR). This type II transmembrane glycoprotein is expressed on cells as a disulfide-linked homodimer comprised of 95 kDa monomers. CD71 is expressed on activated lymphocytes, monocytes, macrophages, erythroid progenitors, brain endothelium, and most proliferating cells. CD71 is not expressed on resting lymphocytes and is upregulated during lymphocyte responses to antigens or mitogens. Through an endocytic pathway, the transferrin receptor mediates cellular iron uptake by binding and internalizing iron that is bound to transferrin. After releasing iron within the low pH endosomal environment, transferrin and its receptor can be recycled to the cell surfa
H0362	PE Human CD73 Antibody [AD2]	CD73, also known as ecto-5'-nucleotidase, is a 70 kDa, glycosyl phosphatidylinositol (GPI)-anchored glycoprotein. CD73 is expressed on subsets of T and B lymphocytes, follicular dendritic cells, epithelial cells, endothelial cells and mesenchymal stem cells. Its expression on lymphocytes increases during T and B cell development. CD73 has enzymatic activity and catalyzes the dephosphorylation of adenosine monophosphate (AMP), converting it to adenosine. It has been suggested that CD73 can mediate costimulatory signals in T cell activation and adhesion of lymphocytes to endothelium.
H0542	PE Human CD8 Antibody [SK1]	CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.
H2417	PE Human CD81 Antibody [JS-81]	CD81 is an ~26 kDa transmembrane protein that belongs to the tetraspanin (TM4SF) family. It is involved in cell growth and signal transduction. CD81 has a very broad cellular distribution, being expressed on cells of hematopoietic, neuroectodermal and mesenchymal origin. In hematopoietic cells, the CD81 antigen is expressed on B and T lymphocytes, NK cells, thymocytes, eosinophils, germinal center follicular dendritic cells, and to a variable extent on monocytes. The CD81 antigen is not expressed on neutrophils, platelets, or erythrocytes. CD81-specific antibodies have been shown to have anti-proliferative effects on different lymphoid cell lines, particularly those derived from large cell lymphomas. They are also reported to induce homotyp
H1472	PE Human CD83 Antibody [HB15e]	CD83 is a 45 kDa type I transmembrane glycoprotein that belongs to the immunoglobulin (Ig) superfamily. It is composed of a single V-type Ig extracellular domain and a C-terminal cytoplasmic tail. CD83 is primarily expressed on the surface of follicular dendritic cells, circulating dendritic cells, interdigitating dendritic cells in lymphoid tissues, in vitro-generated dendritic cells, and thymic dendritic cells. However, its expression is not limited to dendritic cells; it is also found on some germinal center B cells and certain lymphoblastoid cell lines. While the exact function of CD83 is not fully understood, it is believed to play a role in cell-cell interactions during antigen presentation.
H4022	PE Human CD9 Antibody [HI9a]
H0302	PE Human CD90 Antibody [P15F7]	CD90, also known as Thy-1, is a 25-35 kDa glycophosphatidylinositol-anchored membrane glycoprotein of the Ig superfamily. It is expressed on 1-4% of human fetal liver cells, cord blood cells, and bone marrow cells. CD90 is present on a subset of immature CD34+ cells and a distinct subset of mature CD34- cells that are CD3+CD4+. The CD90+CD34+ population is highly enriched for cells capable of long-term culture. The anti-CD90 antibody is useful for enriching high proliferative potential colony-forming cells (HIPP-CFC), which are primitive progenitor cells.
H1817	PE Human CD94 Antibody [HP-3D9]
H2057	PE Human CD96/Tactile Antibody [NK92.39]
H2042	PE Human CD99 Antibody [3B2/TA8]
H2177	PE Human CEACAM-1/CD66a Antibody [283340]
H2867	PE Human CXCR1/IL-8RA Antibody [42705]
H1697	PE Human Galectin-9 Antibody [9M1-3]
H2027	PE Human Ganglioside GD2 Antibody [14G2a]
H2072	PE Human Granzyme A Antibody [CB9]
H0467	PE Human HLA Antibody [G46-6]	HLA-DR, a major histocompatibility complex (MHC) class II antigen, is encoded by genes within the Human Leukocyte Antigen (HLA) Complex located on chromosome 6. HLA-DR is a transmembrane heterodimeric glycoprotein composed of an α chain (36 kDa) and a β subunit (27 kDa) expressed primarily on antigen presenting cells including B cells, dendritic cells, monocytes, macrophages, Langerhans cells, and thymic epithelial cells. HLA-DR is also expressed on activated T cells. This molecule plays a major role in mediating cellular interactions during antigen presentation to CD4-positive T cells.
H3692	PE Human IgD Antibody [IA6-2]	IgD is a member of the immunoglobulin superfamily that exists in type 1-membrane (mIgD) and soluble glycoprotein forms. mIgD is expressed on mature naïve B cells (along with membrane IgM) and serves as a B-cell receptor for antigen (BCR). In response to antigen binding, the mIgD BCR, in association with other signaling molecules including CD79a and CD79b, can transduce activating or tolerizing signals intracellularly into B lymphocytes.
H3707	PE Human IgG Antibody [G18-145]	IgG plays a critical role in the humoral immune response, helping to control infections. It is produced by plasma B-cells and is found in extracellular fluids such as blood, lymph, peritoneal, and cerebrospinal fluids. IgG molecules are monomers consisting of two identical heavy chains and two identical light chains, forming a Y-shaped structure with two antigen-binding sites. IgG facilitates pathogen neutralization, activates the complement system, promotes phagocytosis, and mediates antibody-dependent cellular cytotoxicity. It is also the main antibody involved in long-term immunity and can cross the placenta to provide passive immunity to the fetus. There are four IgG subclasses in humans, mice, and rats-IgG1, IgG2, IgG3, and IgG4-each w
H2267	PE Human IgG Fc Antibody [M1310G05]
H1007	PE Human IgM Antibody [MHM-88]	IgM is the first immunoglobulin made by B cells in the immune response. Surface IgM is expressed on immature and mature B cells, while IgM heavy (μ) chain is expressed intracellularly in pre-B cells.
H0797	PE Human IL-10 Antibody [JES3-19F1]
H1217	PE Human IL-2 Antibody [MQ1-17H12]	Interleukin-2 (IL-2) is a key cytokine involved in immune response and tolerance. It is produced by activated T cells and plays a crucial role in the activation, growth, proliferation, and differentiation of various immune cells, including T and B lymphocytes, LAK cells, NK cells, and monocytes/macrophages. IL-2 exerts its effects through binding to IL-2 receptor complexes, which include the intermediate-affinity IL-2R (comprising IL-2Rβ and γc) and the high-affinity IL-2R (which also includes IL-2Rα, along with IL-2Rβ and γc). IL-2 is essential for the proper functioning of the immune system, particularly in promoting T cell expansion and immune responses.
H0422	PE Human IL-4 Antibody [MP4-25D2]
H2357	PE Human IL-9 Antibody [MH9A3]
H1907	PE Human LAP/TGF-β1 Antibody [27232]
H2627	PE Human NKB1 Antibody [DX9]	CD158e1 functions as a killer cell inhibitory receptor (KIR) and is encoded by KIR3DL1 (Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail). CD158e1 is a 70 kDa glycoprotein that belongs to the Ig superfamily. It is expressed on a subset of natural killer cells and a small subset of T cells. Expression of CD158e1 has been observed to vary among individuals. KIR molecules specifically recognize a certain group of HLA class I antigens. Interaction of CD158e1 with specific HLA-B antigen on a target cell appears to inhibit cell-mediated cytotoxicity by delivering a negative signal that prevents lymphocyte activation. It is suggested that this MHC class I-KIR interaction works as a signaling mechanism that regulates
H0902	PE Human NKG2C/CD159c Antibody [134591]	Human NKG2C (also known as NK cell Group 2 isoform C, killer cell lectin like receptor subfamily C, member 2) is a member of the C type lectin like superfamily. NK receptors are expressed on both NK cells and cytotoxic CD8⁺ T cells and include both activating and inhibitory members. Regulation of the balance between activating and inhibitory receptors is important and its disruption has been implicated in autoimmunity. The NKG2 family includes NKG2A, -B, -C, -D, -E, -F, and -H; except for NKG2D and NKG2F, these receptors form heterodimers with CD94. NKG2C interacts with the adapter molecule DAP12 and operates as an activating receptor when paired with CD94. Human NKG2C is synthesized as a 231 amino acid protein, comprising a 70 aa cytoplasm
H2852	PE Human P-glycoprotein/CD243 Antibody [17F9]
H4292	PE Human PD-L1 Antibody [29E.2A3]	PD-L1 is a 40 kDa type I transmembrane protein that belongs to the B7 family of the Ig superfamily. PD-L1 is expressed on T lymphocytes, B lymphocytes, NK cels, dendritic cels, as wel as IFNγ stimulated monocytes, epithelial cels and endothelial cels. PD-L1 binds to its receptor, PD-1, found on CD4 and CD8 thymocytes as wel as activated T and B lymphocytes and myeloid cels. Engagement of PD-L1 with PD-1 leads to inhibition of TCR-mediated T cel proliferation and cytokine production. PD-L1 is thought to play an important role in tumor immune evasion. Induced PD-L1 expression is common in many tumors and results in increased resistance of tumor cels to CD8 T cel mediated lysis.
H3167	PE Human ROR1 Antibody [2A2]
H4397	PE human SSEA-4 Antibody [MC813]	The antibody reacts with Stage-Specific Embryonic Antigen-4 (SSEA-4), a carbohydrate epitope on the major ganglioside, but not the neutral glycolipid, of human teratocarcinoma cells. As its name implies, the expression of SSEA-4 is stage-specific and can be used to characterize embryonic cells and monitor their differentiation. However, its expression pattern differs in the human and mouse. In the human, SSEA-4 is found on teratocarcinoma (embryonal carcinoma or EC), embryonic inner cell mass (ICM), embryonic stem (ES) cells, and the K562 erythromyeloid leukeumia cell line. As human stem cells undergo differentiation, SSEA-4 expression is lost. In the mouse, SSEA-4 is found on oocytes and early cleavage-stage embryos, and primitive ect
H0962	PE Human TCR gammadelta Antibody [B1]
H2492	PE Human TCR Vgamma9 Antibody [B3]
H1487	PE Human TCR α/β Antibody [IP26]	TCR α/β is a monomorphic determinant of the α/β T-cell receptor, which is expressed on over 95% of normal peripheral blood CD3+ T cells. The α/β T-cell receptor (TCR) plays a crucial role in recognizing peptides bound to MHC molecules, leading to T-cell activation.
H0602	PE Human VEGFR2/KDR/Flk-1 Antibody [89106]	VEGFR2 (KDR/Flk-1), VEGFR1 (Flt-1), and VEGFR3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domains and kinase insert domains in their intracellular regions. The expression of VEGFR1, 2, and 3 is almost exclusively restricted to the endothelial cells. These receptors are likely to play essential roles in vasculogenesis and angiogenesis. VEGFR2 cDNA encodes a 1356 amino acid (aa) residue precursor protein with a 19 aa residue signal peptide. Mature VEGFR2 is composed of a 745 aa residue extracellular domain, a 25 aa residue transmembrane domain and a 567 aa residue cytoplasmic domain. In contrast to VEGFR1 which binds both P
H0122	PE IFN-gamma Antibody [4S.B3]
G0947	PE IgM Antibody [II/41]	Mouse IgM is an immunoglobulin M antibody that is produced by B cells in response to an antigen. It is the first antibody produced during an immune response and is the largest immunoglobulin in the serum. Mouse IgM is composed of five heavy chains and five light chains, and it is involved in complement activation and agglutination of antigens. It plays a crucial role in the innate immune response and is important for neutralizing pathogens before the adaptive immune response is fully activated. Mouse IgM is widely used in research and diagnostic applications, including ELISA, Western blotting, and immunohistochemistry.
G1907	PE IL-12/IL-23 p40 Antibody [C17.8]
G4082	PE IL-13 Antibody [D16G3]
G0182	PE IL-17A Antibody [G2J2]
G1922	PE IL-6 Antibody [MQ2-13A5]
G2537	PE IRF4 Antibody [3E4]
G3947	PE Junctional Adhesion Molecule 1/JAM-A Antibody [C23D13]
G0317	PE Ki-67 Antibody [SolA15]	Ki-67 is a nuclear protein that is expressed during various stages in the cell cycle, particularly during late G1, S, G2, and M phases. The protein has a forkhead associated domain (FHA) through which it associates with euchromatin at the perichromosomal layer, the centromeric heterochromatin, and the nucleolus. Ki-67 is shown to have a cell cycle dependent topographical distribution with perinucleolar expression at G1, expression in the nuclear matrix at G2, and expression on the chromosomes during M phase. Ki-67 is commonly used as a proliferation marker because it is not detected in G0 cells, but increases steadily from G1 through mitosis. Ki-67 antibodies are useful in establishing the cell growing fraction in neoplasms. In neoplastic t
G2657	PE LAMP2 Antibody [H4B4]
G0362	PE Ly-6A/E/Sca-1 Antibody [D7]	Stem Cell Antigen-1 (Sca-1) is a member of the lymphocyte antigen 6 (Ly-6) family. It is expressed on multipotent hematopoietic stem cells (HSC) and is used as a marker of HSC in mice. Sca-1 is used in combination with lineage depletion antibodies to identify murine HSC. Sca-1 can be found in fetal liver, adult bone marrow, and adult peripheral blood and spleen. Sca-1 may be involved in the regulation of B and T cell activation.
G1607	PE Mouse CCR1 Antibody [643854]
G1952	PE Mouse CD104 Antibody [346-11A]
G0437	PE Mouse CD107a Antibody [1D4B]	CD107a, also known as Lysosome-Associated Membrane Protein 1 (LAMP-1), is a type I transmembrane glycoprotein that serves as a key marker of lysosomes. It is composed of a 40 kDa core protein that is heavily glycosylated, resulting in a mature glycoprotein ranging from 110 to 140 kDa. CD107a is predominantly expressed in epithelial cells and macrophages across various organs. Upon cellular activation, it translocates to the cell surface of lymphocytes, macrophages, epithelial cells, endothelial cells, platelets, and tumor cells. Surface expression of CD107a is involved in intercellular and extracellular matrix adhesion and is widely used as a functional marker of cytotoxic activity in NK cells and CD8+ T cells, as well as in identifying som
G2672	PE Mouse CD107b Antibody [M3/84]
G1697	PE Mouse CD124 Antibody [mIL4R-M1]
G4112	PE Mouse CD138 Antibody [281-2]	CD138 (Syndecan-1) is a transmembrane proteoglycan containing both heparan sulfate and chondroitin sulfate chains. It binds to components of the extracellular matrix and plays a critical role in cell adhesion, proliferation, and signaling. CD138 is predominantly expressed on epithelial cells, where its presence is associated with normal epithelial architecture. It is also expressed on B lymphocytes during specific stages of differentiation, including precursor B cells in the bone marrow and antibody-secreting plasma cells, but is absent on mature peripheral B cells. This expression pattern implicates CD138 in B cell–matrix interactions. Its expression is regulated during embryonic development and is subject to tissue-specific structural pol
G0977	PE Mouse CD146 Antibody [ME-9F1]	CD146, also known as melanoma cell adhesion molecule (MCAM or Mel-CAM), MUC18, S-Endo1, and A32 antigen, is an integral membrane glycoprotein that belongs to the Ig superfamily. CD146 is strongly expressed by murine vascular endothelial cells. It is expressed on about 30% of neutrophils and 60% of NK cells. Unlike in humans, CD146 is undetectable on monocytes, dendritic cells, T cells, NKT cells, B cells, or smooth muscle cells in mouse. It has been reported that an increase in CD146 expression is associated with NK cell maturation. Combined with using CD27 and CD11b staining, CD146 may be an alternative marker to detect final stages of NK cell maturation and define NK cell subsets. CD146+ NK cells were found to be less cytotoxic and to pro
G0647	PE Mouse CD150/SLAM Antibody [TC15-12F12.2]	CD150 is a 75-95 kD member of the immunoglobulin superfamily, also known as SLAM (signaling lymphocyte activation molecule) or IPO-3. CD150, a single chain type I transmembrane molecule, is expressed on thymocytes, T cell subsets, B cells, dendritic cells, and endothelial cells. The expression is upregulated upon activation. CD150 expression has been shown to be maintained on Th1 but not Th2 clones. T regulatory cells express a relatively high level of CD150. Antibodies against CD150 have been shown to augment IFN-γ production by Th1 cells, especially when co-stimulated through the TCR. CD150 associates with the src homology 2-domain-containing protein tyrosine phosphatase SHP-2, and this association is thought to be involved in signal tran
G1427	PE Mouse CD159a Antibody [16A11]
G4232	PE Mouse CD16/CD32 Antibody [2.4G2]	CD16 and CD32 are expressed on B cells, monocytes/macrophages, NK cells, granulocytes, mast cells, and dendritic cells. These receptors bind to the Fc portion of antibody-antigen complexes and play a role in adaptive immune responses.
G2357	PE Mouse CD180 Antibody [RP/14]
G1082	PE Mouse CD185 Antibody [2G8]	The Rat Anti-Mouse CD185 (CXCR5) monoclonal antibody specifically binds to the mouse C-X-C Chemokine Receptor type 5, CXCR5. CXCR5 is also known as CD185, BLR1, NLR and MDR15. CXCR5 is a seven-transmembrane, G-protein-coupled receptor that is specific for the CXC chemokine, CXCL13/BLC/BCA-1. The expression of CXCR5 has been detected in spleen, lymph nodes, tonsils, brain, bone marrow, T cells, B cells, cerebrum, cerebellum, hippcampus and pituitary. In mouse spleen, CXCR5 was strictly expressed by mature B cells and a small subset of T lymphocytes. CXCR5 plays a role in directing the migration of B and T cells to B cell follicles with the spleen and certain other lymphoid tissues. The immunogen used to generate 2G8 hybridoma was a recombina
G4382	PE Mouse CD19 Antibody [1D3]	CD19, a B lymphocyte-lineage differentiation antigen and a 95-kDa transmembrane glycoprotein, is a member of the immunoglobulin superfamily and is expressed throughout B-lymphocyte development from the pro-B cell stage through mature B cells. Terminally differentiated plasma cells do not express CD19. On mature B cells, CD19 associates with CD21 (CR-2) and CD81 (TAPA-1), forming a multimolecular complex that synergizes with surface immunoglobulin to promote cellular activation. Studies in CD19-deficient mice suggest that the level of CD19 expression influences the generation and maturation of B cells in both bone marrow and peripheral tissues. B-1 lineage B cells, also called CD5+ B cells, are drastically reduced or absent in CD19-deficient
G3017	PE Mouse CD196/CCR6 Antibody [29-2L17]	CCR6 is a G-protein linked chemokine receptor which binds the chemokine CCL20/MIP-3a. It is expressed on B lymphocytes and certain subsets of dendritic cells and T cells. CCR6 is reported to be involved in mucosal immune response and lymphocyte migration and homeostasis.
G1547	PE Mouse CD205/DEC-205 Antibody [NLDC-145]	CD205, also known as DEC-205, is a 205 kD integral membrane protein homologous to the macrophage mannose receptor. It is a type I cell surface protein that belong to the C-type lectin family. CD205 is expressed at high levels by dendritic cells and thymic epithelial cells. It is also expressed by a number of other cell types, such as B lymphocytes, macrophages, Langerhans cells, bone marrow stromal cells, granulocytes, epithelial cells of pulmonary airways, and the capillaries of the brain. CD205 is a novel endocytic receptor used by dendritic cells and thymic epithelial cells to direct captured antigens from the extracellular space to specialized antigen processing. It mediates antigen uptake and presentation and cross-presentation to
G4067	PE Mouse CD206/MMR Antibody [C068C2]	CD206, also known as mannose receptor (MR), is a 175 kD type I membrane protein. It is a pattern recognition receptor (PRR) belonging to the C-type lectin superfamily. MR is expressed on macrophages, dendritic cells, Langerhans cells, and hepatic or lymphatic endothelial cells. MR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine through its C-type lectin-like carbohydrate recognition domains, sulfated carbohydrate antigens through its cysteine-rich domain, and collagens through its fibronectin type II domain. MR mediates endocytosis and phagocytosis as well as activation of macrophages and antigen presentation. It plays an important role in host defense and provides a link between innate and ada
G0812	PE Mouse CD21/CD35 Antibody [7G6]	This antibody recognizes an epitope shared by 145-150-kDa and 190-kDa complement receptor proteins, originally designated CR2 (CD21) and CR1 (CD35), respectively. In the mouse, CD21 and CD35 are expressed on the majority of peripheral B lymphocytes, on the majority of resident peritoneal macrophages and mast cells, on peripheral blood granulocytes after treatment with N-formyl-Met-Leu-Phe, and on follicular dendritic cells, but not on thymocytes, T cells, erythrocytes, or platelets. CD21 is a ligand-binding component of the CD19/CD21/CD81 signal-transduction complex associated with the antigen receptor on B lymphocytes. CD21/CD35 also co-localizes with CD19 on the surface of peritoneal mast cells. Cr2null mice display impaired inflammatory
G1862	PE Mouse CD268/BAFF-R Antibody [7H22-E16]
G4907	PE mouse CD275 Antibody [HK5.3]
G3047	PE Mouse CD282/TLR2 Antibody [CB225]
G4637	PE Mouse CD3 Antibody [17A2]	CD3ε is one of five polypeptide chains that combine to form the TCR complex. CD3ε is expressed on T lymphocytes, NK-T cels, and to varying degrees on developing thymocytes. CD3 plays roles in TCR signaling, T lymphocyte activation, and antigen recognition.
G2237	PE Mouse CD301b/MGL2 Antibody [URA-1]
G1337	PE Mouse CD304 Antibody [3E12]
G1412	PE Mouse CD317 Antibody [927]
G1247	PE Mouse CD357/GITR Antibody [DTA-1]	CD357, also known as GITR (Glucocorticoid-induced Tumor Necrosis Factor Receptor family-Related), is a 66-70 kDa homodimer glycoprotein that belongs to the TNF receptor superfamily. It is also referred to as TNFRSF18. GITR expression was first identified in T lymphocytes treated with dexamethasone, a glucocorticoid. In normal naive mice, GITR is expressed at moderate levels on CD25-positive/CD4-positive/CD8a-negative thymocytes and on CD25-positive/CD4-positive/CD45RB-low splenocytes. It is also expressed at low levels on splenic CD25-negative/CD4-positive/CD45RB-low T lymphocytes, B lymphocytes, macrophages, and dendritic cells. GITR expression is upregulated upon activation of T and B lymphocytes. As a costimulatory receptor, GITR plays a
G2402	PE Mouse CD369/Clec7a/Dectin-1 Antibody [RH1]
G2012	PE Mouse CD371 Antibody [5D3/CLEC12A]
G0842	PE Mouse CD38 Antibody [90]	CD38 is a 45 kD type II transmembrane glycoprotein also known as T10. It is an ADP-ribosyl hydrolase expressed at variable levels on hematopoietic cells and in some non-hematopoietic tissues (such as brain, muscle, and kidney). In humans, it is expressed at high levels on plasma cells and activated T and B cells, natural killer (NK) lymphocytes, myeloblasts, and erythroblasts. By functioning as both a cyclase and a hydrolase, CD38 mediates lymphocyte activation, adhesion, and the metabolism of cADPR and NAADP. CD31 is the ligand of CD38.
G4157	PE Mouse CD3epsilon Antibody [145-2C11]	CD3epsilon is a 20 kDa transmembrane cell-surface protein that belongs to the immunoglobulin superfamily. It is one of five polypeptide chains that combine to form the T cell receptor (TCR) complex. CD3ε is expressed on T lymphocytes, NK-T cells, and to varying degrees on developing thymocytes. CD3 plays critical roles in TCR signaling, T lymphocyte activation, and antigen recognition.
G4142	PE Mouse CD4 Antibody [GK1.5]	The CD4 antigen is a 55 kDa cell surface type I membrane glycoprotein belonging to the immunoglobulin superfamily. CD4 acts as a co-receptor which, in cooperation with the T cell receptor (TCR), interacts with class II MHC molecules displayed by antigen-presenting cells (APC). CD4 is expressed by the majority of thymocytes, most helper T cells, a subset of NK-T cells, and weakly by dendritic cells and macrophages. CD4 plays an important role in the development of T cells and is required for mature T cells to function optimally.
G0512	PE Mouse CD40 Antibody [1C10]	CD40 is a single-chain glycoprotein and a member of the tumor necrosis factor receptor (TNFR) family, exhibiting significant homology to the Hodgkin's disease-associated antigen, CD30. It is expressed by B lymphocytes, follicular dendritic cells, thymic epithelium, and a subset of peripheral T cells, as well as some epithelial cells, carcinomas, and lymphoid dendritic cells. Notably, CD40 is present on all B cells except plasma cells. CD40 plays a crucial role in regulating B cell development and maturation, inducing immunoglobulin isotype-switching, and protecting B cells from surface Ig-induced apoptosis when combined with other signals such as IL-4. It promotes proliferation and is essential for T cell-dependent immunoglobulin class swit
G4832	PE Mouse CD40L Antibody [MR-1]
G0857	PE Mouse CD41 Antibody [MWReg30]	CD41 is a transmembrane glycoprotein that is encoded by Itga2b. CD41 associates with Integrin β3 chain (gpIIIa or CD61) to form the gpIIb/IIIa (CD41/CD61) complex. CD41/CD61 is expressed on platelets, megakaryocytes, and early hematopoietic progenitors. The integrin complex binds to fibrinogen, fibronectin, vitronectin, von Willebrand factor, and thrombospondin. It is important for platelet adhesion and aggregation, and it may play a role in osteolytic tumor metastasis.
G1037	PE Mouse CD43 Activation-Associated Glycoform Antibody [1B11]	CD43, also known as Ly-48, Leukosialin, Sialophorin, Leukocyte Sialoglycoprotein, and gp115, is a large single chain of type I transmembrane glycoprotein with abundant O-glycosylation and sialylation sites. Due to variable glycosylation and sialylation, two isoforms of CD43 have been identified. The 115 kD glycoform of CD43 is expressed on most hematopietic cells including T lymphocytes, NK cells, monocytes, granulocytes, platelets, and CD5+ B cells. It is not present on resting B cells and erythrocytes. While the 130 kD glycoform is thought to be activation-associated form primarily expressed on myeloid cells, pre-B cells, and activated T cells. It has been reported that CD43 binds to CD54 and Siglec-1. CD43 plays dual roles in cell adhesi
G0527	PE Mouse CD49b Antibody [DX5]	CD49b is a 150 kDa transmembrane glycoprotein that non-covalently associates with CD29 (integrin β1) to form the integrin α2β1 complex known as VLA-2. The rat anti-mouse CD49b antibody has been reported to identify the majority of NK cells and a small T-cell subpopulation in most mouse strains (e.g., A/J, AKR, BALB/c, C3H/HeJ, C57BL/6, C57BL/10, C57BR, C58, CBA/Ca, DBA/1, DBA/2, SJL, SWR, 129/J, but not NOD). The DX5 antibody also recognizes platelets that express high levels of CD49b.
G0542	PE Mouse CD49b Antibody [HMα2]
G1112	PE Mouse CD54 Antibody [YN1/1.7.4]	CD54 is a 90 kD immunoglobulin superfamily member also known as ICAM-1 and Ly-47. It is expressed on activated endothelial cells, high endothelial venules (HEV), T and B cells, monocytes/ macrophages, granulocytes, and dendritic cells. CD54 is an important intracellular adhesion molecule that participates in T cell-T cell, T cell-B cell, and T cell-target cell interactions via binding of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). CD54 has also been shown to be involved in lymphocyte trafficking, making it an important molecule in many immune reactions and inflammation. CD54 is also a receptor for rhinovirus. Antibodies against CD54 can block its interaction with LFA-1 and Mac-1, thereby inhibiting cell-cell adhesion, impairing antigen prese
G2252	PE Mouse CD62E Antibody [10E9.6]
G2942	PE Mouse CD64 Antibody [X54-5/7.1]	CD64 is a 72 kD single chain type I glycoprotein also known as FcγRI and FcRI. CD64 is a member of the immunoglobulin superfamily and is expressed on monocytes/macrophages, dendritic cells, and mast cells. The expression can be upregulated by IFN-γ stimulation. CD64 binds IgG immune complex. It plays a role in antigen capture, phagocytosis of IgG/antigen complexes, and antibody-dependent cellular cytotoxicity (ADCC).
G1742	PE Mouse CD79b/Igβ Antibody [HM79-12]
G1322	PE Mouse CD83 Antibody [Michel-19]
G4412	PE Mouse CD86 Antibody [GL1]	CD86, along with CD80, is a member of the B7 family of costimulatory molecules and plays a crucial role in T cell activation and immune response regulation. CD86 is expressed at low levels on B cells, macrophages, and dendritic cells, and its expression is upregulated on B cells through various stimuli, including the BCR complex, CD40, and certain cytokine receptors. As a type I membrane protein and member of the immunoglobulin superfamily, CD86 serves as a ligand for the T cell surface proteins CD28 and CTLA-4 (CD152). The interaction between CD86 and CD28 provides a costimulatory signal essential for T cell activation during antigen presentation, while binding with CTLA-4 negatively regulates T cell activation, diminishing the immune resp
G4847	PE Mouse CD8β Antibody [53-5.8]
G4367	PE Mouse CXCR3 Antibody [CXCR3-173]	CXCR3, also known as CD183, is a 38 kDa chemokine receptor for CXCL9 (MIG), CXCL10 (IP-10), and CXCL11 (ITAC). CXCR3 is expressed primarily on activated T cells, NK cells, as well as some epithelial and endothelial cells. CXCR3 mediates leukocyte trafficking. Binding of chemokine ligands to CXCR3 induces various cellular responses, including integrin activation, cytoskeletal changes, and chemotactic migration. An antibody targeting CXCR3 binds to the receptor and inhibits its interaction with CXCL10 and CXCL11, but not CXCL9.
G1802	PE Mouse H-2Kb Antibody [AF6-88.5]	H-2Kb is a mouse MHC class I alloantigen expressed on all nucleated cells of mice with the H-2^b haplotype. It plays a key role in presenting endogenous peptides to CD8+ T cells, enabling immune surveillance and cytotoxic T cell responses.
G1502	PE Mouse I-A[b] Antibody [AF6-120.1]	I-A[b] is a major histocompatibility complex (MHC) class II molecule found on antigen-presenting cells such as B cells, dendritic cells, and macrophages. It presents peptides derived from extracellular proteins to CD4+ T helper cells, playing a critical role in initiating and regulating adaptive immune responses
G4187	PE Mouse IgG1 isotype control Antibody [MOPC-21]	Mouse IgG1 isotype control is a mouse myeloma protein. It was selected as an isotype control following screening for low background on a variety of mouse and human tissues.
G4877	PE Mouse IgG2a isotype control Antibody [C1.18.4]
G0782	PE Mouse IL-10 Antibody [JES5-16E3]	IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. D
G4217	PE Mouse IL-4 Antibody [11B11]	IL-4 (interleukin-4) is a multifunctional 14 kDa cytokine. IL-4 is mainly produced by activated Th2 and NK cells, with smaller contributions from mast cells and basophils. It signals via the IL-4Rα receptor. Once bound to its receptor, IL-4 promotes the proliferation of activated B and T cells and drives B cell differentiation into plasma cells. It also facilitates class switching to IgE in B cells and enhances MHC class II expression, while suppressing Th1 cell development, macrophage activity, IFNγ production, and IL-12 release by dendritic cells. IL-4, like other cytokines associated with Th2 responses, contributes to airway inflammation commonly seen in allergic asthma.
G4277	PE Mouse IL-6 Antibody [MP5-20F3]
G4577	PE Mouse IL-6R Antibody [15A7]
G4322	PE Mouse LAG-3 Antibody [C9B7W]
G1637	PE Mouse LAP/TGF-β1 Antibody [TW7-16B4]
G4307	PE Mouse LFA-1α/CD11a Antibody [M17/4]	LFA-1α (lymphocyte function-associated antigen 1 alpha), also known as integrin alpha L chain and CD11a, pairs with CD18 to form LFA-1, a 180 kDa integrin glycoprotein belonging to the integrin family. LFA-1 is expressed on the surface of all leukocytes, including lymphocytes, monocytes, macrophages, and granulocytes. It plays a central role in leukocyte intercellular adhesion through interactions with its ligands ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50), and also contributes to lymphocyte costimulatory signaling.
G4427	PE Mouse Ly6G Antibody [1A8]	Lymphocyte antigen 6 complex, locus G (Ly-6G), is a 21–25 kDa GPI-anchored protein expressed primarily on peripheral granulocytes and highly specific for neutrophils. Ly-6G serves as a robust marker for neutrophil identification and depletion in mice. Ly-6G modulates neutrophil migration and recruitment to sites of inflammation via interaction with β2 integrins. Its downregulation is associated with age-related functional decline in neutrophils.
G4247	PE Mouse NK1.1 Antibody [PK136]	NK1.1, also known as CD161b/CD161c, KLRB1, NKR-P1A, and Ly-55, is a type II integral membrane glycoprotein with a C-type lectin domain and is encoded by the Klrb1c/NKR-P1C gene. NK1.1 plays roles in NK cell activation and differentiation, IFN-γ production, cytotoxic granule release, and is thought to be involved in the generation of Th2 cells. NK1.1 is predominantly expressed as a disulfide-linked homodimer on NK cells; however, it is also expressed on NK-T cells, a rare population of T lymphocytes. NK1.1 is only expressed by C57BL/6, FVB/N, and NZB strains of mice and not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129 strains.
G4802	PE Mouse OX40 Antibody [OX-86]
G4262	PE Mouse PD-L1 Antibody [10F.9G2]	PD-L1 (programmed death ligand 1), also known as B7-H1 or CD274, is a 40 kDa type I transmembrane protein that belongs to the B7 family of the immunoglobulin superfamily. PD-L1 is expressed on T lymphocytes, B lymphocytes, NK cells, dendritic cells, as well as IFNγ-stimulated monocytes, epithelial cells, and endothelial cells. PD-L1 binds to its receptor, PD-1, found on CD4 and CD8 thymocytes as well as activated T and B lymphocytes and myeloid cells. Engagement of PD-L1 with PD-1 leads to inhibition of TCR-mediated T cell proliferation and cytokine production. PD-L1 is thought to play an important role in tumor immune evasion. Induced PD-L1 expression is common in many tumors and results in increased resistance of tumor cells to CD8 T cell
G0467	PE Mouse Siglec-F Antibody [E50-2440]	Siglecs are the sialic acid-binding immunoglobulin superfamily lectins defined in the human, each of which has a distinctive expression pattern in the hematopoietic system and at least some of which are known to mediate cell-cell interactions. Orthologous proteins of human Siglec-1 (Sialoadhesin or CD169), Siglec-2 (CD22), and Siglec-4 (myelin-associated glycoprotein) have been characterized in the mouse. Human Siglec-3 (CD33) and Siglecs-5 through -10 are encoded by a cluster of closely related genes, and each has two cytoplasmic ITIM (Immunoreceptor Tyrosine-based Inhibitory Motifs). Similarly, mouse Siglec-F is encoded by the Siglecf gene in a syntenic cluster in the mouse, and the protein has sialic acid-binding activity and an intracyt
G1667	PE Mouse TCR Vα2 Antibody [B20.1]	TCR Vα2 is a distinct T-cell receptor (TCR) subfamily found in mice with the a, b, and c haplotypes. The TCR α chain complexes with the TCR β chain in 95% of T cells, forming the T cell receptor (α/β TCR), while the remaining 5% of T cells express gamma (γ) and delta (δ) chains (γ/δ TCR). TCR Vα2 represents a specific variant of the TCR α chain that plays a role in antigen recognition and is useful in the study of T-cell function and immune responses in mice with these specific haplotypes.
G4352	PE Mouse Ter-119 Antibody [TER-119]	TER-119 is a lineage marker for erythroid cells from early proerythroblast to mature erythrocyte stages in adult blood, spleen, and bone marrow. It is also present in yolk sac, and fetal and newborn liver. The TER-119 antigen is not expressed by cells of earlier erythroid development at BFU-e (blast-forming unit erythroid) stage or CFU-e (colony-forming unit erythroid) stage.
G4892	PE mouse TIGIT Antibody [1G9]
G2597	PE Mouse TSPAN8 Antibody [657909]
G4667	PE mouse/human CD11b Antibody [M1/70]
G2027	PE Mouse/rat CD81 Antibody [Eat-2]	CD81 is a 26 kD non-glycosylated member of the tetraspanin superfamily (TM4SF), also known as TAPA-1. CD81 is expressed on T and B cells, NK cells, dendritic cells, thymocytes, endothelial cells, and fibroblasts. CD81 induces B cell adhesion via the VLA-4 integrin and has been shown to play a role in early T cell development. CD81 associates with several other cell-surface proteins in a multimolecular complex, including CD19, CD21, CD20, CD37, CD53, and CD82 in B cells, and CD4, CD8 and CD82 in T cells.
G1127	PE Perforin Antibody [K20N5]
G3842	PE Phospho-Histone H2A.X (Ser139) Antibody [E5F13]
G1292	PE Podoplanin Antibody [L7B2]	Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin type-1 glycoprotein with a 40-43 kDa molecular weight. Podoplanin is expressed in many tumors and normal cells, especially lymphatic epithelial cells and follicular DCs. Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. Podoplanin appears to serve as a ligand for CLEC-2 and expression is positively correlated with tumors expressing greater invasive and metastatic potential. Podoplanin is directly involved in cell migration, aids metastases formation and tumor cell invasion of tissue. Further, it has also been determined that
G4292	PE Rat IgG2a isotype control Antibody [2A3]
G0632	PE Rat IgG2a kappa Isotype Control Antibody [eBR2a]	Rat IgG2a is an immunoglobulin subclass that is commonly used in research and diagnostic applications. It is produced by the rat immune system and is known for its ability to activate complement and mediate antibody-dependent cell-mediated cytotoxicity (ADCC). Rat IgG2a has a molecular weight of approximately 160 kDa and is composed of two heavy chains and two light chains. It is often used as a control or reference antibody in experiments involving rat models, and is also commonly used in flow cytometry and immunohistochemistry applications.
G4487	PE Rat IgG2b Isotype Antibody [LTF-2]
G0887	PE Rat IgG2b kappa Isotype Control Antibody [eB149/10H5]	Rat IgG2b is a protein-coding gene that encodes for the immunoglobulin G2b (IgG2b) subclass of rat antibodies. IgG2b is a major subclass of rat immunoglobulins that plays a crucial role in the immune response by neutralizing pathogens and promoting opsonization. Rat IgG2b is commonly used in research applications, such as in immunohistochemistry, flow cytometry, and Western blotting.
G3512	PE Rat/Mouse CD49a Antibody [Ha31/8]
G0587	PE RORgammat Antibody [AFKJS-9]	ROR gamma, a NR1 Thyroid Hormone-Like receptor, has been shown to affect thymopoiesis, bone metabolism, T-cell apoptosis, and lymphoid organogenesis. ROR gamma has been shown to promote thymocyte survival by activating the expression of the antiapoptotic protein Bcl-x(L). ROR gamma is also required for the development of lymph nodes and Peyer's patches. It has been shown that ROR gamma(t), a thymus-specific isoform of ROR gamma from mouse, inhibits Fas ligand expression and cytokine secretion in immature thymocytes. ROR gamma binds as a monomer to response elements composed of a single core motif, GGTCA, preceded by a 6 bp AT-rich sequence. ROR gamma expression has been documented in mouse thymus, adipose, bone, skeletal muscle, liver, and
G3827	PE STAT3 (phospho S727) Antibody [B8F21]
G3782	PE Stat3 Antibody [J18A23]
G0617	PE T-bet Antibody [B2D24]	T-bet, also known as TBX21, is a T-cell specific transcription factor containing a single T-box DNA-binding domain. It controls the expression of the TH1 cytokine, interferon-gamma. Both Th1 and Th17 cells are crucial in immune regulation and autoimmune disease development. T-bet initiates Th1 lineage development from naive Th precursor cells and directs T cell differentiation to Th1 versus Th17. T-bet is cooperating with Stat4 (signal tranducer and activator of transcription 4) in programming chromatin architecture for Th1 gene expression. Genetic variations in T-bet are associated with susceptibility to aspirin-induced asthma and nasal polyps.
G4022	PE TCF1/TCF7 Antibody [E19C1]	LEF1 and TCF are members of the high mobility group (HMG) DNA-binding protein family of transcription factors that consists of the following: Lymphoid Enhancer Factor 1 (LEF1), T Cell Factor 1 (TCF1/TCF7), TCF3/TCF7L1, and TCF4/TCF7L2. LEF1 and TCF1/TCF7 were originally identified as important factors that regulate early lymphoid development and act downstream in Wnt signaling. LEF1 and TCF bind to Wnt response elements to provide docking sites for β-catenin, which translocates to the nucleus to promote the transcription of target genes upon activation of Wnt signaling. LEF1 and TCF are dynamically expressed during development and aberrant activation of the Wnt signaling pathway is involved in many types of cancers, including colon cancer.
G0917	PE TCR gammadelta Antibody [J18P6]	TCR gamma/delta (T-cell receptor gamma/delta) are specialized T-cells in the immune system. The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflamm
G0287	PE TCR-β Antibody [H57-597]	The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system c
G3422	PE TLR4/MD-2 Complex Antibody [MTS510]	MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e.g., human MD-2 transfected into mouse cells can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4.
H3002	PE TLR8 Antibody [44C143]
H2342	PE TLR9 Antibody [26C593.2]	Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. TLR9 forms a subfamily along with TLR7 and TLR8 that recognize viral RNA and CpG DNA sequences and are localized in intracellular acidic compartments such as the phagolysosome. Unlike other TLRs which act through adaptor molecules such as TOLLIP, TIRAP, TRIF, and MyD88 to activate various kinases and transcription factors to respond to potential infection, TLR9 is strictly dependent on MyD88.
H0347	PE TNF-α Antibody [MAb11]	TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is mainly secreted by macrophages and binds to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. It exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice suggested the neuroprotective function of TNF alpha, and it has been observed to cause tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to
G0332	PE TNF-α Antibody [MP6-XT22]
G0098	PE-Cy5 CD11c Antibody [N418]
G0773	PE-Cy5 CD135/Flt3 Antibody [A2F10]	FLT3 is a tyrosine protein kinase that is a member of the growth factor receptor tyrosine kinase family. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
H0788	PE-Cy5 CD135/Flt3 Antibody [BV10A4H2]
H0173	PE-Cy5 CD27 Antibody [O323]	CD27 (TNFRSF7) is a cell surface homodimer of ≥55 kDa subunits that provides co-stimulatory signaling in support of T cell (TCR) and B cell (BCR) receptors. Compared to CD28, whose TCR co-stimulatory signal can trigger cell proliferation, CD27 signaling promotes cell survival and differentiation to effector/memory stages. CD27 may be shed following interaction with its ligand CD70, which is typically expressed on activated dendritic cells, T cells, and B cells. In B cells, CD27 is a phenotypic marker for memory B cells and has also been included among markers for identifying B regulatory cells (Bregs), which regulate CD4+ T cell proliferation and Foxp3/CTLA-4 expression in Treg cells.
G1103	PE-Cy5 CD278 Antibody [C398.4A]	ICOS, also known as inducible costimulatory molecule and H4, is a 47-57 kD protein. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes. It is able to costimulate T cells proliferation. In addition, ICOS is involved in humoral immune responses (B cell germinal center formation). The ICOS ligand is B7h/B7RP-1 or B7-H2. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development.
G0083	PE-Cy5 CD44 Antibody [IM7]	CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential. CD44 is expressed by hematopoietic, non-hematopoietic cells, epithelial tissu
G0023	PE-Cy5 CD45 Antibody [30-F11]	CD45, also known as Leukocyte Common Antigen (LCA). CD45 is expressed by all hematopoietic cells excluding mature erythrocytes and platelets. The cytoplasmic portion of CD45 has tyrosine phosphatase enzymatic activity and plays an important role in activation of lymphocytes.
G0353	PE-Cy5 CD45.1 Antibody [A20]	CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides t
G0113	PE-Cy5 CD45R/B220 Antibody [RA3-6B2]
G3488	PE-Cy5 CD5 Antibody [53-7.3]	CD5 is a 67 kDa human T-lymphocyte single-chain transmembrane glycoprotein. CD5 is present on all mature T-lymphocytes, on most of thymocytes and on many T-cell leukemias and lymphomas. CD5 also reacts with a subpopulation of activated B-cells and may act as a receptor in regulating T-cell proliferation. CD5 is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. CD5 is expressed by many T cell leukemia, lymphomas, and activated T cells. Diseases associated with CD5 dysfunction include thymus cancer and Richter's Syndrome.
G0248	PE-Cy5 CD62L/L-Selectin Antibody [MEL-14]	The human CD62L is a 74-95 kDa glycoprotein member of the selectin family of adhesion receptors. L-Selectin is comprised of an aminoterminal C-type lectin binding domain, an epidermal growth factor-like domain, two short consensus repeat (SCR) sequences homologous to those found in complement binding proteins, a short spacer region, a transmembrane region and a short cytoplasmic region. Human CD62L (L-Selectin) is constitutively expressed on all classes of leukocytes including lymphocytes (except a substantial population of memory T cells), monocytes and polymorphonuclear cells.
G0218	PE-Cy5 CD80/B7-1 Antibody [16-10A1]	CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28, and of an inhibitory receptor CTLA-4 (CD152). Both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, and both molecules can also substitute for each other in this process. CD80 is rapidly induced on the surface of in vitro activated B cells, with Epstein Barr Virus (EBV) transformed B cell lines, with Burkitts lymphoma cell lines, with freshly isolated follicular B lymphoma cells, T cells, and monocytes. The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 and CTLA4 ligands of T cells. Diseases associated with CD80 dysfunct
G0743	PE-Cy5 CD90.1/Thy-1.1 Antibody [HIS51]	CD90 (Thy 1) antigen is a GPI linked glycoprotein member of the Immunoglobulin super family. It is expressed in murine T cells, thymocytes, neural cells, Kupffer's cells and fibroblasts. Thy 1 may play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
G4928	PE-Cy5 CXCR4 Antibody [UMB2]
G2828	PE-Cy5 EOMES Antibody [Dan11mag]	Eomes is a T-box transcription factor that is highly homologous to T-bet, which is essential during trophoblast development and gastrulation in most vertebrates. In the immune system, Eomes controls the differentiation of effector and memory CD8+ T cells, as well as natural killer (NK) cells. Expression of Eomes in these cells correlates with high expression of CD122, the common beta-chain of the IL-2R and IL-15R.TBR2 is a member of a conserved protein family that shares a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. A similiar protein disrupted in mice is shown to be essential during trophoblast development and gastrulation. TBR2 plays a role in brain
G0068	PE-Cy5 F4/80 Antibody [BM8]
G0038	PE-Cy5 FOXP3 Antibody [FJK-16s]	FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-alle
H1463	PE-Cy5 Human CD10 Antibody [HI10a]	CD10, also known as Neutral Endopeptidase (NEP), Enkephalinase, Atriopeptidase, and Neprilysin, is a 100 kDa type II transmembrane glycoprotein encoded by the MME (membrane metallo-endopeptidase) gene. CD10 has neutral endopeptidase activity and is also referred to as the Common Acute Lymphoblastic Leukemia Antigen (CALLA). It is expressed on a wide variety of normal and neoplastic cell types, including granulocytes, bone marrow stromal cells, a subset of B-cell progenitors, germinal center B cells, and fibroblasts. CD10 is a cell surface metalloendopeptidase that inactivates several signaling molecules, playing a significant regulatory role in the nervous, immune, and other systems.
H0458	PE-Cy5 Human CD107a Antibody [H4A3]	CD107a, also known as Lysosomal-associated membrane protein 1 (LAMP-1), is a ~110 kDa type I transmembrane protein that is heavily glycosylated and widely expressed by cells primarily on the luminal surface of their lysosomes. It is also expressed on the surface of activated platelets, activated lymphocytes, cytotoxic T cells and NK cells, and some tumor cell lines, including U937 and KG1a. LAMP-1 can serve as a ligand for E-selectin-mediated cell adhesion. LAMP-1 and LAMP-2 (CD107b) are carriers for poly-N-acetyllactosamines and are able to display sialyl Le[x] termini.
H0383	PE-Cy5 Human CD117 Antibody [104D2]	CD117 is a 145 kD protein tyrosine kinase also known as c-Kit. It is a receptor for stem cell factor or c-Kit ligand. CD117 is expressed on pluripotent hematopoietic progenitor cells (approximately 1-4% bone marrow cells), mast cells, and acute myeloid leukemia cells (AML). CD117 binding of c-Kit ligand induces phosphorylation of CD117 and stimulates proliferation and survival of primitive hematopoietic stem cells as well as erythroid-committed and granulo-monocytic committed cells.
H3323	PE-Cy5 Human CD11a Antibody [HI111]
H0068	PE-Cy5 Human CD11b Antibody [ICRF44]
H3803	PE-Cy5 Human CD137 Antibody [4B4-1]	CD137 is a 39 kD transmembrane protein also known as 4-1BB. It is expressed on activated T cells. CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily. CD137 appears to be important for T cell proliferation and survival, and induces monocyte activation through its interaction with 4-1BB ligand.
H4058	PE-Cy5 Human CD140b Antibody [18A2]
H1133	PE-Cy5 Human CD16 Antibody [3G8]	CD16a is a ~50–65 kDa type I transmembrane glycoprotein encoded by FCGR3A (Fc fragment of IgG receptor IIIa), which belongs to the immunoglobulin superfamily. CD16a is also known as Fc-gamma RIII-alpha (FcγRIIIA or FcRIIIa) and is expressed on natural killer (NK) cells, activated monocytes, macrophages, γδ T cells, immature thymocytes, and mast cells. CD16a binds immune-complexed or aggregated IgG and associates with CD247/TCRζ in NK cells and FcεRIγ chains in phagocytes and mast cells to transduce intracellular signals. CD16a functions in antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses including phagocytosis, cytokine production, or mediator release. CD16b is a ~48 kDa glycophosphatidylinositol (GPI)-
H0008	PE-Cy5 Human CD19 Antibody [HIB19]
H1028	PE-Cy5 Human CD195 Antibody [2D7/CCR5]	CCR5, also known as CD195, is a seven transmembrane-spanning G protein-coupled receptor (GPCR) that belongs to the beta chemokine receptor family. It is expressed on a subset of T lymphocytes (CD3⁺CD45RO⁺CD95⁺). CCR5 plays a key role in regulating lymphocyte chemotaxis, activation, and transendothelial migration during inflammation by responding to at least three chemokines: RANTES (Regulated upon Activation, Normal T-cell Expressed and Secreted), MIP-1 (Macrophage Inflammatory Protein-1), and MCP-2 (Monocyte Chemoattractant Protein 2). Additionally, CCR5 serves as a coreceptor for macrophage-tropic HIV-1 on CD4⁺ T cells, which is critical for viral entry and transmission. Individuals with partial (heterozygous) or complete (homozygous) del
H1583	PE-Cy5 Human CD1a Antibody [HI149]	CD1a is a type I transmembrane glycoprotein. The 49 kDa CD1a polypeptide is associated with β2-microglobulin. CD1a is expressed on cortical thymocytes, dendritic cells and Langerhans cells. CD1a has structural similarities to the MHC class I antigen, and plays a role in antigen presentation.
H2303	PE-Cy5 Human CD21 Antibody [B-ly4]
H4253	PE-Cy5 Human CD25 Antibody [M-A251]	The CD25 antigen is also known as the human low-affinity interleukin-2 receptor α chain (IL-2Rα) and the Tac antigen. The CD25antigen is present on a subset of peripheral blood lymphocytes. Antigen density increases on phytohemagglutinin (PHA)-, concanavalin A (Con A)-, and CD3-activated T lymphocytes; T lymphocytes from mixed lymphocyte cultures; and HTLV-infected T-lymphocyte leukemia lines, for example, HUT-102. Recombinant IL-2 blocks the binding of CD25 to PHA-activated T lymphocytes. CD4+/CD25+ regulatory T cells might directly regulate the function of responsive T cells. The CD25antibody is composed of mouse IgG1 heavy chains and kappa light chains
H4283	PE-Cy5 Human CD3 Antibody [OKT-3]	CD3ε is one of five polypeptide chains that combine to form the TCR complex. CD3ε is expressed on T lymphocytes, NK-T cels, and to varying degrees on developing thymocytes. CD3 plays roles in TCR signaling, T lymphocyte activation, and antigen recognition.
H0923	PE-Cy5 Human CD33 Antibody [WM53]	CD33, also known as Sialic acid-binding Ig-like lectin 3 (Siglec-3), gp67, or p67, is a 67 kDa type I transmembrane glycoprotein expressed on monocytes, activated T cells, myeloid progenitors, and mast cells. CD33 is absent on normal platelets, lymphocytes, erythrocytes, and hematopoietic stem cells. This glycoprotein can reportedly function as a sialic acid-dependent cell adhesion molecule. This function can be modulated by endogenous sialoglycoconjugates when CD33 is expressed on the membrane.
H3653	PE-Cy5 Human CD366 Antibody [F38-2E2]	CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells). Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance.
H0038	PE-Cy5 Human CD4 Antibody [RPA-T4]	CD4 is a 56 kDa transmembrane glycoprotein expressed on the T-helper/inducer subset of normal human peripheral blood lymphocytes. The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex
H0563	PE-Cy5 Human CD40 Antibody [5C3]
H0893	PE-Cy5 Human CD41a Antibody [HIP8]	CD41a, also known as Integrin αIIb or Platelet GPIIb, forms a calcium-dependent complex with CD61 (β3 integrin or GPIIIa) that is normally expressed on platelets and megakaryocytes. The CD41/CD61 complex serves as a receptor for fibrinogen, fibronectin, and von Willebrand factor, mediating platelet adhesion and aggregation. Blocking CD41 can completely inhibit ADP-, epinephrine-, and collagen-induced platelet activation, and partially inhibit ristocetin- and thrombin-induced activation.
H0098	PE-Cy5 Human CD45 Antibody [HI30]	CD45 is encoded by the PTPRC (Protein tyrosine phosphatase receptor type C) gene. CD45, also known as the leukocyte common antigen (LCA), is a member of the protein tyrosine phosphatase (PTP) family. It is present on all human leukocytes including lymphocytes, monocytes, granulocytes, eosinophils, and thymocytes. CD45 is absent from circulating erythrocytes, platelets, or mature erythroid cells of bone marrow and non-hemopoietic tissues.
H0743	PE-Cy5 Human CD45RA Antibody [HI100]	CD45RA, a 220 kDa isoform of the human leukocyte common antigen, is expressed on approximately 40–50% of peripheral CD4+ T cells, 50% of peripheral CD8+ T cells, and on a portion of B cells and monocytes. The CD45RA antigen is expressed by naïve and activated T cells. CD45RA-specific antibodies are useful for the study of the suppressor/inducer subpopulation of CD4+ lymphocytes.
H4013	PE-Cy5 Human CD45RO Antibody [UCHL1]
H0533	PE-Cy5 Human CD49f Antibody [GoH3]	CD49f, also known as the integrin α6 chain, is a ~150 kDa type I transmembrane glycoprotein that belongs to the integrin alpha chain family of extracellular matrix and cell adhesion receptors. The integrin α6 subunit associates with the integrin β1 chain (CD29) to form VLA-6, and with the integrin β4 chain (CD104) to form the integrin α6β4 complex, also known as the laminin and kalinin receptor. CD49f is expressed mainly on T cells, monocytes, platelets, epithelial cells, endothelial cells, perineural cells, and trophoblasts of the placenta. Antibodies against CD49f can block the binding of integrin α6 to laminin P1 and E8 fragments.
H4268	PE-Cy5 Human CD56/NCAM-1 Antibody [B159]	CD56 is a heavily glycosylated adhesion protein that is present on a subpopulation of peripheral blood large granular lymphocytes that demonstrate natural killer activity. CD56 is also expressed on a subset of T cells but is not expressed on myeloid cells, erythrocytes or B cells. This antigen is a pan-NK-cell marker. CD56 is virtually identical to an isoform of the neural cell adhesion molecule (NCAM), a structure mediating homotypic and heterotypic cell-cell interactions.
H3998	PE-Cy5 Human CD7 Antibody [M-T701]
H3938	PE-Cy5 Human CD71 Antibody [M-A712]	This antibody specifically binds to CD71 which is also known as the transferrin receptor (TFR). This type II transmembrane glycoprotein is expressed on cells as a disulfide-linked homodimer comprised of 95 kDa monomers. CD71 is expressed on activated lymphocytes, monocytes, macrophages, erythroid progenitors, brain endothelium, and most proliferating cells. CD71 is not expressed on resting lymphocytes and is upregulated during lymphocyte responses to antigens or mitogens. Through an endocytic pathway, the transferrin receptor mediates cellular iron uptake by binding and internalizing iron that is bound to transferrin. After releasing iron within the low pH endosomal environment, transferrin and its receptor can be recycled to the cell surfa
H1478	PE-Cy5 Human CD83 Antibody [HB15e]	CD83 is a 45 kDa type I transmembrane glycoprotein that belongs to the immunoglobulin (Ig) superfamily. It is composed of a single V-type Ig extracellular domain and a C-terminal cytoplasmic tail. CD83 is primarily expressed on the surface of follicular dendritic cells, circulating dendritic cells, interdigitating dendritic cells in lymphoid tissues, in vitro-generated dendritic cells, and thymic dendritic cells. However, its expression is not limited to dendritic cells; it is also found on some germinal center B cells and certain lymphoblastoid cell lines. While the exact function of CD83 is not fully understood, it is believed to play a role in cell-cell interactions during antigen presentation.
H0308	PE-Cy5 Human CD90 Antibody [P15F7]	CD90, also known as Thy-1, is a 25-35 kDa glycophosphatidylinositol-anchored membrane glycoprotein of the Ig superfamily. It is expressed on 1-4% of human fetal liver cells, cord blood cells, and bone marrow cells. CD90 is present on a subset of immature CD34+ cells and a distinct subset of mature CD34- cells that are CD3+CD4+. The CD90+CD34+ population is highly enriched for cells capable of long-term culture. The anti-CD90 antibody is useful for enriching high proliferative potential colony-forming cells (HIPP-CFC), which are primitive progenitor cells.
H3698	PE-Cy5 Human IgD Antibody [IA6-2]	IgD is a member of the immunoglobulin superfamily that exists in type 1-membrane (mIgD) and soluble glycoprotein forms. mIgD is expressed on mature naïve B cells (along with membrane IgM) and serves as a B-cell receptor for antigen (BCR). In response to antigen binding, the mIgD BCR, in association with other signaling molecules including CD79a and CD79b, can transduce activating or tolerizing signals intracellularly into B lymphocytes.
G1598	PE-Cy5 Human/Mouse Integrin β7 Antibody [FIB504]	Integrin β7 is a 130 kD glycoprotein also known as integin βp. It is a member of the Ig superfamily. In association with integrin α4 or αE chain, β7 forms α4/β7 or αE/β7 heterodimer. α4/β7 (CD49d/β7, LPAM-1) is expressed on the majority of peripheral lymphocytes, on small subsets of thymocytes, and bone marrow progenitors. LPAM-1 binds to several ligands, VCAM-1, MAdCAM-1 and fibronectin, and is involved in lymphocyte adhesion and some hematopoietic progenitor cells migration. αE/β7 (CD103/β7,αIEL/β7) is expressed on intestinal intraepithelial lymphocytes (IEL), dendritic epidermal T cells, T regulatory cells, a subset of CD8+ T cells in lymph nodes and lamina propria. CD103/β7 complex is thought to play a role in lymphocyte retention via i
G0953	PE-Cy5 IgM Antibody [II/41]	Mouse IgM is an immunoglobulin M antibody that is produced by B cells in response to an antigen. It is the first antibody produced during an immune response and is the largest immunoglobulin in the serum. Mouse IgM is composed of five heavy chains and five light chains, and it is involved in complement activation and agglutination of antigens. It plays a crucial role in the innate immune response and is important for neutralizing pathogens before the adaptive immune response is fully activated. Mouse IgM is widely used in research and diagnostic applications, including ELISA, Western blotting, and immunohistochemistry.
G0323	PE-Cy5 Ki-67 Antibody [SolA15]	Ki-67 is a nuclear protein that is expressed during various stages in the cell cycle, particularly during late G1, S, G2, and M phases. The protein has a forkhead associated domain (FHA) through which it associates with euchromatin at the perichromosomal layer, the centromeric heterochromatin, and the nucleolus. Ki-67 is shown to have a cell cycle dependent topographical distribution with perinucleolar expression at G1, expression in the nuclear matrix at G2, and expression on the chromosomes during M phase. Ki-67 is commonly used as a proliferation marker because it is not detected in G0 cells, but increases steadily from G1 through mitosis. Ki-67 antibodies are useful in establishing the cell growing fraction in neoplasms. In neoplastic t
G2663	PE-Cy5 LAMP2 Antibody [H4B4]
G0368	PE-Cy5 Ly-6A/E/Sca-1 Antibody [D7]	Stem Cell Antigen-1 (Sca-1) is a member of the lymphocyte antigen 6 (Ly-6) family. It is expressed on multipotent hematopoietic stem cells (HSC) and is used as a marker of HSC in mice. Sca-1 is used in combination with lineage depletion antibodies to identify murine HSC. Sca-1 can be found in fetal liver, adult bone marrow, and adult peripheral blood and spleen. Sca-1 may be involved in the regulation of B and T cell activation.
G0653	PE-Cy5 Mouse CD150/SLAM Antibody [TC15-12F12.2]	CD150 is a 75-95 kD member of the immunoglobulin superfamily, also known as SLAM (signaling lymphocyte activation molecule) or IPO-3. CD150, a single chain type I transmembrane molecule, is expressed on thymocytes, T cell subsets, B cells, dendritic cells, and endothelial cells. The expression is upregulated upon activation. CD150 expression has been shown to be maintained on Th1 but not Th2 clones. T regulatory cells express a relatively high level of CD150. Antibodies against CD150 have been shown to augment IFN-γ production by Th1 cells, especially when co-stimulated through the TCR. CD150 associates with the src homology 2-domain-containing protein tyrosine phosphatase SHP-2, and this association is thought to be involved in signal tran
G4388	PE-Cy5 Mouse CD19 Antibody [1D3]	CD19, a B lymphocyte-lineage differentiation antigen and a 95-kDa transmembrane glycoprotein, is a member of the immunoglobulin superfamily and is expressed throughout B-lymphocyte development from the pro-B cell stage through mature B cells. Terminally differentiated plasma cells do not express CD19. On mature B cells, CD19 associates with CD21 (CR-2) and CD81 (TAPA-1), forming a multimolecular complex that synergizes with surface immunoglobulin to promote cellular activation. Studies in CD19-deficient mice suggest that the level of CD19 expression influences the generation and maturation of B cells in both bone marrow and peripheral tissues. B-1 lineage B cells, also called CD5+ B cells, are drastically reduced or absent in CD19-deficient
G4208	PE-Cy5 Mouse CD25/IL-2Rα Antibody [PC61.5]
G4148	PE-Cy5 Mouse CD4 Antibody [GK1.5]	The CD4 antigen is a 55 kDa cell surface type I membrane glycoprotein belonging to the immunoglobulin superfamily. CD4 acts as a co-receptor which, in cooperation with the T cell receptor (TCR), interacts with class II MHC molecules displayed by antigen-presenting cells (APC). CD4 is expressed by the majority of thymocytes, most helper T cells, a subset of NK-T cells, and weakly by dendritic cells and macrophages. CD4 plays an important role in the development of T cells and is required for mature T cells to function optimally.
G0518	PE-Cy5 Mouse CD40 Antibody [1C10]	CD40 is a single-chain glycoprotein and a member of the tumor necrosis factor receptor (TNFR) family, exhibiting significant homology to the Hodgkin's disease-associated antigen, CD30. It is expressed by B lymphocytes, follicular dendritic cells, thymic epithelium, and a subset of peripheral T cells, as well as some epithelial cells, carcinomas, and lymphoid dendritic cells. Notably, CD40 is present on all B cells except plasma cells. CD40 plays a crucial role in regulating B cell development and maturation, inducing immunoglobulin isotype-switching, and protecting B cells from surface Ig-induced apoptosis when combined with other signals such as IL-4. It promotes proliferation and is essential for T cell-dependent immunoglobulin class swit
G1043	PE-Cy5 Mouse CD43 Activation-Associated Glycoform Antibody [1B11]
G0533	PE-Cy5 Mouse CD49b Antibody [DX5]	CD49b is a 150 kDa transmembrane glycoprotein that non-covalently associates with CD29 (integrin β1) to form the integrin α2β1 complex known as VLA-2. The rat anti-mouse CD49b antibody has been reported to identify the majority of NK cells and a small T-cell subpopulation in most mouse strains (e.g., A/J, AKR, BALB/c, C3H/HeJ, C57BL/6, C57BL/10, C57BR, C58, CBA/Ca, DBA/1, DBA/2, SJL, SWR, 129/J, but not NOD). The DX5 antibody also recognizes platelets that express high levels of CD49b.
G4418	PE-Cy5 Mouse CD86 Antibody [GL1]	CD86, along with CD80, is a member of the B7 family of costimulatory molecules and plays a crucial role in T cell activation and immune response regulation. CD86 is expressed at low levels on B cells, macrophages, and dendritic cells, and its expression is upregulated on B cells through various stimuli, including the BCR complex, CD40, and certain cytokine receptors. As a type I membrane protein and member of the immunoglobulin superfamily, CD86 serves as a ligand for the T cell surface proteins CD28 and CTLA-4 (CD152). The interaction between CD86 and CD28 provides a costimulatory signal essential for T cell activation during antigen presentation, while binding with CTLA-4 negatively regulates T cell activation, diminishing the immune resp
G0878	PE-Cy5 Mouse IgG2a κ Isotype Control Antibody [G155-178]
G4253	PE-Cy5 Mouse NK1.1 Antibody [PK136]	NK1.1, also known as CD161b/CD161c, KLRB1, NKR-P1A, and Ly-55, is a type II integral membrane glycoprotein with a C-type lectin domain and is encoded by the Klrb1c/NKR-P1C gene. NK1.1 plays roles in NK cell activation and differentiation, IFN-γ production, cytotoxic granule release, and is thought to be involved in the generation of Th2 cells. NK1.1 is predominantly expressed as a disulfide-linked homodimer on NK cells; however, it is also expressed on NK-T cells, a rare population of T lymphocytes. NK1.1 is only expressed by C57BL/6, FVB/N, and NZB strains of mice and not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129 strains.
G4358	PE-Cy5 Mouse Ter-119 Antibody [TER-119]	TER-119 is a lineage marker for erythroid cells from early proerythroblast to mature erythrocyte stages in adult blood, spleen, and bone marrow. It is also present in yolk sac, and fetal and newborn liver. The TER-119 antigen is not expressed by cells of earlier erythroid development at BFU-e (blast-forming unit erythroid) stage or CFU-e (colony-forming unit erythroid) stage.
G4673	PE-Cy5 mouse/human CD11b Antibody [M1/70]
G4493	PE-Cy5 Rat IgG2b Isotype Antibody [LTF-2]
G0893	PE-Cy5 Rat IgG2b kappa Isotype Control Antibody [eB149/10H5]
G0623	PE-Cy5 T-bet Antibody [B2D24]	T-bet, also known as TBX21, is a T-cell specific transcription factor containing a single T-box DNA-binding domain. It controls the expression of the TH1 cytokine, interferon-gamma. Both Th1 and Th17 cells are crucial in immune regulation and autoimmune disease development. T-bet initiates Th1 lineage development from naive Th precursor cells and directs T cell differentiation to Th1 versus Th17. T-bet is cooperating with Stat4 (signal tranducer and activator of transcription 4) in programming chromatin architecture for Th1 gene expression. Genetic variations in T-bet are associated with susceptibility to aspirin-induced asthma and nasal polyps.
G0293	PE-Cy5 TCR-β Antibody [H57-597]	The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system c
G0103	PE-Cy5.5 CD11c Antibody [N418]
G0028	PE-Cy5.5 CD45 Antibody [30-F11]	CD45, also known as Leukocyte Common Antigen (LCA). CD45 is expressed by all hematopoietic cells excluding mature erythrocytes and platelets. The cytoplasmic portion of CD45 has tyrosine phosphatase enzymatic activity and plays an important role in activation of lymphocytes.
G0118	PE-Cy5.5 CD45R/B220 Antibody [RA3-6B2]	CD45R (PTPRC) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. CD45 contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. CD45 is specifically expressed in hematopoietic cells and has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists in multiple isoforms as a result of alternative splicing, and these isoforms di
G0013	PE-Cy5.5 CD8a Antibody [53-6.7]
H0403	PE-Cy5.5 Granzyme B Antibody [GB11]	Granzyme B is a member of the granzyme serine protease family, and is found in the granules of cytotoxic T cells and NK cells. Granzyme B has been described as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation, and CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells. Granzyme B is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. The receptor involved in this process has been identified as mannose 6-phosphate receptor which functions as a death receptor for Granzyme B during cytotoxic T cell-induced ap
H0148	PE-Cy5.5 Human CD11c Antibody [3.9]	CD11c is a 145–150 kDa type I transmembrane glycoprotein also known as integrin αx and CR4. CD11c non-covalently associates with integrin β2 (CD18) and is expressed on monocytes/macrophages, dendritic cells, granulocytes, NK cells, and subsets of T and B cells. CD11c has been reported to play a role in adhesion and CTL killing through its interactions with fibrinogen, CD54, and iC3b.
H2818	PE-Cy5.5 Human CD158b/j Antibody [DX27]
H1168	PE-Cy5.5 Human CD20 Antibody [2H7]	CD20 is a 33-37 kD, four transmembrane spanning protein, also known as B1 and Bp35. CD20 is expressed on pre-B-cells, resting and activated B cells (not plasma cells), some follicular dendritic cells, and at low levels on a T cell subset. CD20 is heavily phosphorylated on activated B cells and malignant B cells. Homo-oligomeric complexes of CD20 are thought to form Ca2+ conductive ion channels in the plasma membrane of B cells. The CD20 molecule is involved in B-cell activation and is associated with various Src family kinases (Lyn, Lck, Fyn). It exists in a complex with MHC class I and II, CD53, CD81, and CD82.
H4288	PE-Cy5.5 Human CD3 Antibody [OKT-3]	CD3ε is one of five polypeptide chains that combine to form the TCR complex. CD3ε is expressed on T lymphocytes, NK-T cels, and to varying degrees on developing thymocytes. CD3 plays roles in TCR signaling, T lymphocyte activation, and antigen recognition.
H0928	PE-Cy5.5 Human CD33 Antibody [WM53]	CD33, also known as Sialic acid-binding Ig-like lectin 3 (Siglec-3), gp67, or p67, is a 67 kDa type I transmembrane glycoprotein expressed on monocytes, activated T cells, myeloid progenitors, and mast cells. CD33 is absent on normal platelets, lymphocytes, erythrocytes, and hematopoietic stem cells. This glycoprotein can reportedly function as a sialic acid-dependent cell adhesion molecule. This function can be modulated by endogenous sialoglycoconjugates when CD33 is expressed on the membrane.
H3658	PE-Cy5.5 Human CD366 Antibody [F38-2E2]
H0103	PE-Cy5.5 Human CD45 Antibody [HI30]	CD45 is encoded by the PTPRC (Protein tyrosine phosphatase receptor type C) gene. CD45, also known as the leukocyte common antigen (LCA), is a member of the protein tyrosine phosphatase (PTP) family. It is present on all human leukocytes including lymphocytes, monocytes, granulocytes, eosinophils, and thymocytes. CD45 is absent from circulating erythrocytes, platelets, or mature erythroid cells of bone marrow and non-hemopoietic tissues.
H4273	PE-Cy5.5 Human CD56/NCAM-1 Antibody [B159]	CD56 is a heavily glycosylated adhesion protein that is present on a subpopulation of peripheral blood large granular lymphocytes that demonstrate natural killer activity. CD56 is also expressed on a subset of T cells but is not expressed on myeloid cells, erythrocytes or B cells. This antigen is a pan-NK-cell marker. CD56 is virtually identical to an isoform of the neural cell adhesion molecule (NCAM), a structure mediating homotypic and heterotypic cell-cell interactions.
G4393	PE-Cy5.5 Mouse CD19 Antibody [1D3]	CD19, a B lymphocyte-lineage differentiation antigen and a 95-kDa transmembrane glycoprotein, is a member of the immunoglobulin superfamily and is expressed throughout B-lymphocyte development from the pro-B cell stage through mature B cells. Terminally differentiated plasma cells do not express CD19. On mature B cells, CD19 associates with CD21 (CR-2) and CD81 (TAPA-1), forming a multimolecular complex that synergizes with surface immunoglobulin to promote cellular activation. Studies in CD19-deficient mice suggest that the level of CD19 expression influences the generation and maturation of B cells in both bone marrow and peripheral tissues. B-1 lineage B cells, also called CD5+ B cells, are drastically reduced or absent in CD19-deficient
G4213	PE-Cy5.5 Mouse CD25/IL-2Rα Antibody [PC61.5]	Interleukin-2 receptor alpha (IL-2Rα), also known as CD25, Ly-43, p55, or Tac, is the 55 kDa ligand-binding subunit of the interleukin-2 receptor. IL-2Rα is expressed on activated mature T and B lymphocytes, thymocyte subsets, pre-B cells, and T regulatory cells. IL-2Rα plays roles in lymphocyte differentiation, activation, and proliferation. Alone, IL-2Rα binds IL-2 with relatively low affinity; however, when IL-2Rα associates with IL-2Rβ (CD122) and the common gamma chain (CD132), the complex binds IL-2 with high affinity.
G4153	PE-Cy5.5 Mouse CD4 Antibody [GK1.5]	The CD4 antigen is a 55 kDa cell surface type I membrane glycoprotein belonging to the immunoglobulin superfamily. CD4 acts as a co-receptor which, in cooperation with the T cell receptor (TCR), interacts with class II MHC molecules displayed by antigen-presenting cells (APC). CD4 is expressed by the majority of thymocytes, most helper T cells, a subset of NK-T cells, and weakly by dendritic cells and macrophages. CD4 plays an important role in the development of T cells and is required for mature T cells to function optimally.
G4363	PE-Cy5.5 Mouse Ter-119 Antibody [TER-119]	TER-119 is a lineage marker for erythroid cells from early proerythroblast to mature erythrocyte stages in adult blood, spleen, and bone marrow. It is also present in yolk sac, and fetal and newborn liver. The TER-119 antigen is not expressed by cells of earlier erythroid development at BFU-e (blast-forming unit erythroid) stage or CFU-e (colony-forming unit erythroid) stage.
G0898	PE-Cy5.5 Rat IgG2b kappa Isotype Control Antibody [eB149/10H5]
H2989	PE-CY7 BCRP1 Antibody [5D3]	Breast cancer resistance protein (BCRP1), also known as placenta-specific ATP-binding cassette (ABC) protein (ABCP) or ABC G-subfamily member 2 (ABCG2), or mitoxantrone resistance protein (MXR), is a member of the ATP-binding cassette superfamily of drug transporters thought to be involved in multi-drug resistance in human neoplastic disease. ABCG2 is expressed in drug-resistant breast, colon and gastric cancer and fibrosarcoma cancer cell lines and in blast cells from patients with acute myeloid leukemia (AML). Normal tissues that express the ABCG2 protein include placental syncytiothrophoblasts, mammary ducts and lobules, epithelium in the large intestine and colon, venous and capillary epithelium and bile canalicular membrane of the live
G0799	PE-CY7 CD103/Integrin αE Antibody [2E7]	CD103, also known as ITGAE or Integrin alpha E, is a molecule that non-covalently associates with integrin beta 7 to form a heterodimeric integral membrane protein. This protein is part of the integrin family, characterized by an alpha chain and a beta chain. Specifically, CD103 includes a 150 kDa alpha chain and a 120 kDa beta chain, with the alpha integrin undergoing post-translational cleavage in the extracellular domain to yield disulfide-linked heavy and light chains. CD103 is primarily expressed on mucosa-associated T lymphocytes, intraepithelial lymphocytes (IELs), and activated cells, as well as a subset of TGF beta-1 cells. It is preferentially found in human intestinal IELs, where it plays a role in adhesion and may serve as an ac
G3454	PE-CY7 CD105/Endoglin Antibody [MJ7/18]	CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up-regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation-associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.
G4054	PE-CY7 CD117/c-Kit Antibody [2B8]	KIT (c-KIT), also known as CD117, is a proto-oncogene and a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). KIT was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT together with its ligand regulates growth and activation of a variety of hemopoietic and non-hemopoietic cells. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Recently, deregulation of the KIT receptor TK by the prevalent activation loop mutation D816V has served as a focal point in therapeutic strategies aimed at curbing neoplastic mast cell growth. c-Kit is expressed in hematopoietic stem cells, germ cell
G2074	PE-CY7 CD11b+CD11c Antibody [OX42]	CD11b (Integrin αM) and CD11c (Integrin αX) are α-chain integrins that belong to the β2 integrin family. They are primarily expressed on myeloid cells, including monocytes, macrophages, dendritic cells, and neutrophils. These integrins play key roles in cell adhesion, migration, phagocytosis, and immune regulation through interactions with ligands such as iC3b, ICAM-1, and fibrinogen. CD11b is highly expressed on monocytes and neutrophils, whereas CD11c is widely used as a marker for dendritic cells.
G0094	PE-CY7 CD11c Antibody [N418]	CD11, along with CD18, form a heterodimer adhesion molecule. In particular, CD11 is composed of CD11a, CD11b and CD11c. CD11a is a leukocyte marker that is expressed in B and T lymphocytes, macrophages, monocytes, neutrophils, basophils and eosinophils. CD11b is primarily expressed by monocytes, macrophages, natural killer cells, some B and T-cells, and granulocytes. CD11c is expressed in monocytes, macrophages, natural killer cells, some granulocytes and less so in a subset of lymphocytes.
H0784	PE-Cy7 CD135/Flt3 Antibody [BV10A4H2]
G1729	PE-CY7 CD141/Thrombomodulin Antibody [LS17-9]
H0334	PE-CY7 CD161 Antibody [HP-3G10]	CD161, also known as NKR-P1A, is a type II transmembrane lectin-like receptor and member of the killer cell lectin-like receptor (KLR) family. CD161 exists as a homodimer and is prominently expressed on natural killer (NK) and NKT cells, where it is proposed to regulate the function of both cell types. CD161 is also found on T cell subsets, including T regulatory cells (Tregs), memory/effector CD4+ T cells, and CD8+ T cells. Th17 cells have been demonstrated to co-express CD161, as surface IL-17A+ cells are contained within the CD161+ fraction of CD4 T cells, so that CD161 (in combination with CCR6) is often used as a marker for enrichment of Th17 cells.
G0604	PE-CY7 CD184/CXCR4 Antibody [2B11]	CXCR4 (Fusin, LESTR, HUMSTR) is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains, and functions as a co-receptor for X4 HIV-1 entry into CD4⁺ cells. CXCR4 has been proved to be the co-receptor for HIV-2's binding to CD4 through envelope glycoprotein gp 120 and promotes Env-mediated fusion of the virus. In other cases, CXCR4 can even function as the only receptor for HIV-2's binding to the CD4 host cells. CXCR4 is the receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. CXCR4 acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced c
G1714	PE-CY7 CD1d Antibody [1B1]	CD1d is a heavy chain associated with Beta 2 microglobulin on cortical thymocytes. Beta 2 microglobulin independent expression of CD1d has also been demonstrated on human intestinal epithelial cells. CD1d is the sole group 2 member of the CD1 family of major histocompatibility (MHC) like glycoproteins. The CD1d gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1
H1954	PE-CY7 CD1d Antibody [51.1]
G4129	PE-CY7 CD23 Antibody [B3B4]	CD23 is a 45 kDa glycoprotein that serves as a low-affinity receptor for IgE, playing a crucial role in regulating IgE responses and B cell activation. It is expressed on mature B cells, mantle zone B cells, follicular dendritic cells, and at lower levels on T cells, NK cells, Langerhans cells, and platelets. CD23 expression is upregulated upon B cell activation, and its soluble forms are biologically active, acting as potent mitogenic factors. CD23 is strongly expressed on Epstein-Barr virus (EBV)-transformed B lymphoblasts and is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells. It is also detected in neoplastic cells from cases of B cell chronic lymphocytic leukemia and some centroblastic/centrocytic lym
G0274	PE-CY7 CD24 Antibody [M1/69]	CD24 is a 35-50 kDa glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed on a variety of cell types, including erythrocytes, thymocytes, peripheral lymphocytes, and cells of the myeloid lineage. It is variably glycosylated, resulting in heterogeneity in molecular mass across different cell lineages, which can affect antibody staining levels on lymphocyte populations. In the context of B-cell development, CD24 is expressed from the pro-B-cell stage in the bone marrow through to mature, surface Ig-positive B cells, with very low or negative expression on plasma cells. It is also present on the majority of B-lineage acute lymphoblastic leukemias, B-cell chronic lymphocytic leukemias (CCLs), and B-cell non-Hodgkin's lymphomas. CD2
H0169	PE-CY7 CD27 Antibody [O323]	CD27 (TNFRSF7) is a cell surface homodimer of ≥55 kDa subunits that provides co-stimulatory signaling in support of T cell (TCR) and B cell (BCR) receptors. Compared to CD28, whose TCR co-stimulatory signal can trigger cell proliferation, CD27 signaling promotes cell survival and differentiation to effector/memory stages. CD27 may be shed following interaction with its ligand CD70, which is typically expressed on activated dendritic cells, T cells, and B cells. In B cells, CD27 is a phenotypic marker for memory B cells and has also been included among markers for identifying B regulatory cells (Bregs), which regulate CD4+ T cell proliferation and Foxp3/CTLA-4 expression in Treg cells.
H1339	PE-Cy7 CD273 Antibody [MIH18]
G1099	PE-CY7 CD278 Antibody [C398.4A]	ICOS, also known as inducible costimulatory molecule and H4, is a 47-57 kD protein. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes. It is able to costimulate T cells proliferation. In addition, ICOS is involved in humoral immune responses (B cell germinal center formation). The ICOS ligand is B7h/B7RP-1 or B7-H2. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development.
H0694	PE-CY7 CD284/TLR4 Antibody [HTA125]	TLR4 is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This receptor is most abundantly expressed in placenta, and in the myelomonocytic subpopulation of leukocytes. Mammalian cells respond to LPS by activating TLR4. TLR4 belongs to the multi-protein complex of the lipopolysaccharide (LPS) receptor, containing CD14, LY96, and TLR4, and is involved in signal transduction events induced by LPS found in most gram-negative bacteria. TLR4 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents and
G0574	PE-CY7 CD29/ITG-β1 Antibody [C13M2]	CD29, also known as ITGB1 or Integrin Subunit Beta 1, is a 110 kDa cell surface glycoprotein widely expressed by various cells, including all leukocytes. It forms non-covalently linked heterodimers with at least six different alpha integrins (CD49a-f), creating VLA-1 through VLA-6 complexes, as well as with CD51. These alpha-beta integrin heterodimers mediate a range of cellular responses, including adhesion, trafficking, proliferation, and differentiation. CD29-containing integrins bind to extracellular matrix proteins such as collagen, laminin, fibronectin, and vitronectin. Some integrins also interact with cellular receptors like VCAM-1 and MadCAM-1. CD29 plays a crucial role in immune cell trafficking from blood to tissue, particularly
G4099	PE-CY7 CD326/EpCAM Antibody [G8.8]	Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA), also known as CD326, is a transmembrane glycoprotein expressed in the epithelium with a molecular weight of approximately 40 kDa, which functions as an epithelial cell adhesion molecule. Ep-CAM functions as a homotypic calcium-independent cell adhesion molecule, and has a direct impact on cell cycle, proliferation and metabolism of epithelial cells and fibroblasts due to its ability to rapidly induce the proto-oncogene c-myc and the cell cycle regulating genes cyclin A and E. Ep-CAM mediates Ca2+-independent homotypic interactions. Formation of Ep-CAM-mediated adhesions have a negative regulatory effect on adhesions mediated by classic cadherins, which may have strong
G2884	PE-Cy7 CD39 Antibody [24DMS1]
G0079	PE-CY7 CD44 Antibody [IM7]	CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential. CD44 is expressed by hematopoietic, non-hematopoietic cells, epithelial tissu
G0019	PE-CY7 CD45 Antibody [30-F11]	CD45, also known as Leukocyte Common Antigen (LCA). CD45 is expressed by all hematopoietic cells excluding mature erythrocytes and platelets. The cytoplasmic portion of CD45 has tyrosine phosphatase enzymatic activity and plays an important role in activation of lymphocytes.
G0349	PE-CY7 CD45.1 Antibody [A20]	CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides t
G0109	PE-CY7 CD45R/B220 Antibody [RA3-6B2]	CD45R (PTPRC) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. CD45 contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. CD45 is specifically expressed in hematopoietic cells and has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists in multiple isoforms as a result of alternative splicing, and these isoforms di
G3484	PE-CY7 CD5 Antibody [53-7.3]	CD5 is a 67 kDa human T-lymphocyte single-chain transmembrane glycoprotein. CD5 is present on all mature T-lymphocytes, on most of thymocytes and on many T-cell leukemias and lymphomas. CD5 also reacts with a subpopulation of activated B-cells and may act as a receptor in regulating T-cell proliferation. CD5 is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. CD5 is expressed by many T cell leukemia, lymphomas, and activated T cells. Diseases associated with CD5 dysfunction include thymus cancer and Richter's Syndrome.
G0244	PE-CY7 CD62L/L-Selectin Antibody [MEL-14]	The human CD62L is a 74-95 kDa glycoprotein member of the selectin family of adhesion receptors. L-Selectin is comprised of an aminoterminal C-type lectin binding domain, an epidermal growth factor-like domain, two short consensus repeat (SCR) sequences homologous to those found in complement binding proteins, a short spacer region, a transmembrane region and a short cytoplasmic region. Human CD62L (L-Selectin) is constitutively expressed on all classes of leukocytes including lymphocytes (except a substantial population of memory T cells), monocytes and polymorphonuclear cells.
G0499	PE-CY7 CD68 Antibody [FA-11]	CD68 is considered a pan-macrophage marker, predominantly expressed on the intracellular lysosomes of tissue macrophages/monocytes, including Kupffer cells, microglia, histiocytes and osteoclasts, and is expressed to a lesser extent by dendritic cells and peripheral blood granulocytes. CD68 is expressed by many tumor types including some B cell lymphomas, blastic NK lymphomas, melanomas, granulocytic (myeloid) sarcomas, hairy cell leukemias, and renal, urinary and pancreatic tumors, and can be used to demonstrate the presence/localization of macrophages.
G0214	PE-CY7 CD80/B7-1 Antibody [16-10A1]	CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28, and of an inhibitory receptor CTLA-4 (CD152). Both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, and both molecules can also substitute for each other in this process. CD80 is rapidly induced on the surface of in vitro activated B cells, with Epstein Barr Virus (EBV) transformed B cell lines, with Burkitts lymphoma cell lines, with freshly isolated follicular B lymphoma cells, T cells, and monocytes. The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 and CTLA4 ligands of T cells. Diseases associated with CD80 dysfunct
H2209	PE-CY7 CD85j/ILT2 Antibody [HP-F1]
H3439	PE-CY7 CD85k/ILT3 Antibody [ZM4.1]
H1744	PE-CY7 CD88 Antibody [S5/1]	Mouse anti Human CD88 antibody, recognizes the C5a receptor (C5aR) CD88, which is predominantly expressed on cells of the myeloid lineage. It was raised against a synthetic peptide comprising the N-terminal extracellular domain of the C5aR (met1-Asn31) and has recently been shown to recognise the heptameric peptide (D15DKDTLD21). It has been shown to inhibit the binding of C5a to its receptor.
G0739	PE-CY7 CD90.1/Thy-1.1 Antibody [HIS51]	CD90 (Thy 1) antigen is a GPI linked glycoprotein member of the Immunoglobulin super family. It is expressed in murine T cells, thymocytes, neural cells, Kupffer's cells and fibroblasts. Thy 1 may play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
G4924	PE-CY7 CXCR4 Antibody [UMB2]
G2179	PE-CY7 DYKDDDDK Tag Antibody [L5]	The DYKDDDDK tag is often used as a protein modification in order to simplify the labeling and detection of proteins.This unique amino acid sequence allows for specific antibody detection in western blotting, immunoprecipitation, and immunostaining techniques.Due to the short sequence, this modification is not likely to affect the structure or function of the modified proteins.
G0064	PE-Cy7 F4/80 Antibody [BM8]
H0769	PE-CY7 FCER1A Antibody [AER-37 (CRA1)]	Fc epsilon RI alpha, also known as FcεRIα, is a subunit of the high-affinity receptor for IgE, primarily expressed on mast cells and basophils. Its expression is upregulated by the presence of IgE. FcεRIα forms a tetrameric complex with one beta and two gamma subunits, which are essential for signal transduction. The beta and gamma subunits contain immunoreceptor tyrosine-based activation motifs (ITAMs). The FcεRI complex plays a crucial role in triggering IgE-mediated allergic reactions.When allergen-bound IgE molecules bring together two or more high-affinity IgE receptors, it leads to the release of mediators such as histamine, which are responsible for allergy symptoms.This process couples allergens and mast cells to initiate inflamma
G0754	PE-CY7 FCER1A Antibody [MAR-1]	Fc epsilon RI alpha, also known as FceR1 alpha, is a subunit of the high-affinity receptor for IgE, primarily expressed on mast cells and basophils. Its expression is upregulated by the presence of IgE. Fc epsilon RI alpha forms a tetrameric complex with one beta and two gamma subunits, which are essential for signal transduction. The beta and gamma subunits contain immunoreceptor tyrosine-based activation motifs (ITAMs). The Fc epsilon RI complex plays a crucial role in triggering IgE-mediated allergic reactions. When allergen-bound IgE molecules bring together two or more high-affinity IgE receptors, it leads to the release of mediators such as histamine, which are responsible for allergy symptoms. This process couples allergens and mast
G0034	PE-CY7 FOXP3 Antibody [FJK-16s]	FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-alle
G0724	PE-Cy7 Gata-3 Antibody [TWAJ]
H0394	PE-CY7 Granzyme B Antibody [GB11]	Granzyme B is a member of the granzyme serine protease family, and is found in the granules of cytotoxic T cells and NK cells. Granzyme B has been described as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation, and CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells. Granzyme B is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. The receptor involved in this process has been identified as mannose 6-phosphate receptor which functions as a death receptor for Granzyme B during cytotoxic T cell-induced ap
G3739	PE-CY7 HER2/ErbB2 Antibody [H24A7]	The ErbB2 (HER2) proto-oncogene encodes a 185 kDa transmembrane, receptor-like glycoprotein with intrinsic tyrosine kinase activity. While ErbB2 lacks an identified ligand, ErbB2 kinase activity can be activated in the absence of a ligand when overexpressed and through heteromeric associations with other ErbB family members. Amplification of the ErbB2 gene and overexpression of its product are detected in almost 40% of human breast cancers. Binding of the c-Cbl ubiquitin ligase to ErbB2 at Tyr1112 leads to ErbB2 poly-ubiquitination and enhances degradation of this kinase. ErbB2 is a key therapeutic target in the treatment of breast cancer and other carcinomas and targeting the regulation of ErbB2 degradation by the c-Cbl-regulated proteolyt
H2764	PE-Cy7 Human B7-H4 Antibody [MIH43]
H1459	PE-CY7 Human CD10 Antibody [HI10a]	CD10, also known as Neutral Endopeptidase (NEP), Enkephalinase, Atriopeptidase, and Neprilysin, is a 100 kDa type II transmembrane glycoprotein encoded by the MME (membrane metallo-endopeptidase) gene. CD10 has neutral endopeptidase activity and is also referred to as the Common Acute Lymphoblastic Leukemia Antigen (CALLA). It is expressed on a wide variety of normal and neoplastic cell types, including granulocytes, bone marrow stromal cells, a subset of B-cell progenitors, germinal center B cells, and fibroblasts. CD10 is a cell surface metalloendopeptidase that inactivates several signaling molecules, playing a significant regulatory role in the nervous, immune, and other systems.
H0829	PE-CY7 Human CD103/Integrin αE Antibody [Ber-ACT8]	CD103 is a type I transmembrane glycoprotein also known as αE integrin, integrin αIEL chain, and human mucosal lymphocyte antigen 1. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. Treg cells express high level of CD103. Hairy cell leukemia has also been shown to express CD103. The expression of CD103 on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as an αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD
H0454	PE-CY7 Human CD107a Antibody [H4A3]	CD107a, also known as Lysosomal-associated membrane protein 1 (LAMP-1), is a ~110 kDa type I transmembrane protein that is heavily glycosylated and widely expressed by cells primarily on the luminal surface of their lysosomes. It is also expressed on the surface of activated platelets, activated lymphocytes, cytotoxic T cells and NK cells, and some tumor cell lines, including U937 and KG1a. LAMP-1 can serve as a ligand for E-selectin-mediated cell adhesion. LAMP-1 and LAMP-2 (CD107b) are carriers for poly-N-acetyllactosamines and are able to display sialyl Le[x] termini.
H0379	PE-CY7 Human CD117 Antibody [104D2]	CD117 is a 145 kD protein tyrosine kinase also known as c-Kit. It is a receptor for stem cell factor or c-Kit ligand. CD117 is expressed on pluripotent hematopoietic progenitor cells (approximately 1-4% bone marrow cells), mast cells, and acute myeloid leukemia cells (AML). CD117 binding of c-Kit ligand induces phosphorylation of CD117 and stimulates proliferation and survival of primitive hematopoietic stem cells as well as erythroid-committed and granulo-monocytic committed cells.
H3319	PE-CY7 Human CD11a Antibody [HI111]	This antibody specifically binds to CD11a, the 180 kDa integrin α chain. This type I transmembrane glycoprotein associates with CD18 (integrin β2) to form the heterodimeric glycoprotein CD11a/CD18. This heterodimer is also known as the lymphocyte (leukocytes) function associated antigen-1 (LFA-1) that is expressed on all leukocytes. LFA-1 is an adhesion molecule involved in lymphocyte and granulocyte functions. LFA-1 mediates adhesion of lymphoid cells to the vascular endothelium in association with its ligand, and the intracellular adhesion molecule-1 (ICAM-1), CD54. Other ligands are ICAM-2 (CD102) and ICAM-3 (CD50). Purified Mouse Anti-Human CD11a antibody also cross reacts with all leukocytes of baboon, and both rhesus and cynomolgus ma
H0079	PE-CY7 Human CD11b Antibody [CBRM1/5]	CD11b, a 165-170 kDa type I transmembrane glycoprotein also known as αM integrin, Mac-1, CR3, and C3biR. CD11b non-covalently associates with integrin β2 (CD18) and is expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b/CD18 is critical for the transendothelial migration of monocytes and neutrophils as well as adhesion, phagocytosis, and neutrophil activation. CD11b/CD18 interacts with ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4, CD14, CD23, heparin, iC3b, fibrinogen and factor X.
H0064	PE-CY7 Human CD11b Antibody [ICRF44]	CD11b is a 165-170 kD type I transmembrane glycoprotein also known as αM integrin, Mac-1, CR3, and C3biR. CD11b non-covalently associates with integrin β2 (CD18) and is expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b/CD18 is critical for the transendothelial migration of monocytes and neutrophils. It is also involved in granulocyte adhesion, phagocytosis, and neutrophil activation. CD11b/CD18 interacts with ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4, CD14, CD23, heparin, iC3b, fibrinogen, and factor X.
H0139	PE-CY7 Human CD11c Antibody [3.9]	CD11c is a 145–150 kDa type I transmembrane glycoprotein also known as integrin αx and CR4. CD11c non-covalently associates with integrin β2 (CD18) and is expressed on monocytes/macrophages, dendritic cells, granulocytes, NK cells, and subsets of T and B cells. CD11c has been reported to play a role in adhesion and CTL killing through its interactions with fibrinogen, CD54, and iC3b.
H2569	PE-Cy7 Human CD126/IL-6Rα Antibody [UV4]
H3799	PE-CY7 Human CD137 Antibody [4B4-1]	CD137 is a 39 kD transmembrane protein also known as 4-1BB. It is expressed on activated T cells. CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily. CD137 appears to be important for T cell proliferation and survival, and induces monocyte activation through its interaction with 4-1BB ligand.
H0184	PE-CY7 Human CD14 Antibody [M5E2]	CD14 is a 53–55 kDa glycosylphosphatidylinositol (GPI)-anchored single-chain glycoprotein expressed at high levels on monocytes, macrophages, and neutrophils. CD14 is a multifunctional receptor and is constitutively expressed on the surface of mature monocytes and macrophages. It serves as a high-affinity receptor for lipopolysaccharide (LPS) and binds LPS in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute-phase serum protein. CD14 also exists in a soluble form (sCD14) and is released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. The soluble sCD14 is important for neutralizing allochthonous lipopolysaccharides by reconstituted lipoprotein particles and can discriminate structural dif
H0844	PE-Cy7 Human CD140a/PDGFRα Antibody [16A1]
H1969	PE-CY7 Human CD141/Thrombomodulin Antibody [M80]
H1039	PE-CY7 Human CD146 Antibody [P1H12]	CD146, also known as MCAM, MUC18, or Mel-CAM, is a 118 kDa transmembrane glycoprotein and a member of the immunoglobulin superfamily. It is strongly expressed by blood vessel endothelium and smooth muscle. CD146 is also found on angioblasts, mesenchymal stem cells, melanoma cells, intermediate trophoblasts, and a subset of activated T cells. CD146 is widely used as a marker for endothelial cells and plays a key role in studies of angiogenesis, cancer progression, and vascular biology.
H1354	PE-CY7 Human CD152/CTLA-4 Antibody [BNI3]	CD152, also known as CTLA-4 (Cytolytic T Lymphocyte-Associated Antigen 4), is a molecule transiently expressed on activated CD28+ T cells. It binds to CD80 and CD86 on antigen-presenting cells (APCs) with high avidity, delivering a negative regulatory signal to the T cell. It has also been shown that CTLA-4 is expressed on B cells when cultured with activated T cells, indicating a role in regulating the B-cell response. Additionally, CD152 is expressed on regulatory T (Treg) cells. The BNI3 monoclonal antibody specifically binds to human CTLA-4 and can be used to study its role in T-cell proliferation and regulation.
H1369	PE-Cy7 Human CD155/PVR Antibody [SKII.4]
H2809	PE-CY7 Human CD158b/j Antibody [DX27]
H1129	PE-CY7 Human CD16 Antibody [3G8]	CD16a is a ~50–65 kDa type I transmembrane glycoprotein encoded by FCGR3A (Fc fragment of IgG receptor IIIa), which belongs to the immunoglobulin superfamily. CD16a is also known as Fc-gamma RIII-alpha (FcγRIIIA or FcRIIIa) and is expressed on natural killer (NK) cells, activated monocytes, macrophages, γδ T cells, immature thymocytes, and mast cells. CD16a binds immune-complexed or aggregated IgG and associates with CD247/TCRζ in NK cells and FcεRIγ chains in phagocytes and mast cells to transduce intracellular signals. CD16a functions in antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses including phagocytosis, cytokine production, or mediator release. CD16b is a ~48 kDa glycophosphatidylinositol (GPI)-
H2554	PE-Cy7 Human CD162/IL-6Rα Antibody [KPL-1]
H0949	PE-Cy7 Human CD169 Antibody [7-239]
H2104	PE-CY7 Human CD172a/b Antibody [SE5A5]
H0004	PE-CY7 Human CD19 Antibody [HIB19]	CD19 is a 95 kDa type I transmembrane glycoprotein expressed during all stages of B-cell maturation and differentiation, except on plasma cells. It is also present on follicular dendritic cells but not found on T cells or normal granulocytes. CD19 functions as a signal transduction molecule that regulates B cell development, activation, proliferation, and differentiation. It associates with complement receptor 2 (CD21), TAPA-1 (CD81), Leu 13, and/or MHC class II to form a signal transduction complex on the surface of B cells.
H1534	PE-CY7 Human CD194/CCR4 Antibody [L291H4]
H1024	PE-CY7 Human CD195 Antibody [2D7/CCR5]	CCR5, also known as CD195, is a seven transmembrane-spanning G protein-coupled receptor (GPCR) that belongs to the beta chemokine receptor family. It is expressed on a subset of T lymphocytes (CD3⁺CD45RO⁺CD95⁺). CCR5 plays a key role in regulating lymphocyte chemotaxis, activation, and transendothelial migration during inflammation by responding to at least three chemokines: RANTES (Regulated upon Activation, Normal T-cell Expressed and Secreted), MIP-1 (Macrophage Inflammatory Protein-1), and MCP-2 (Monocyte Chemoattractant Protein 2). Additionally, CCR5 serves as a coreceptor for macrophage-tropic HIV-1 on CD4⁺ T cells, which is critical for viral entry and transmission. Individuals with partial (heterozygous) or complete (homozygous) del
H1579	PE-CY7 Human CD1a Antibody [HI149]	CD1a is a type I transmembrane glycoprotein. The 49 kDa CD1a polypeptide is associated with β2-microglobulin. CD1a is expressed on cortical thymocytes, dendritic cells and Langerhans cells. CD1a has structural similarities to the MHC class I antigen, and plays a role in antigen presentation.
H1594	PE-CY7 Human CD1c Antibody [L161]	CD1c, also known as R7 or M241, is a 43 kD member of the five CD1 antigens (CD1a-e) in humans. The CD1 molecules are type I glycoprotein with structural similarities to MHC class I and are non-covalently associated with β2-microglobulin, belonging to the Ig superfamily. CD1c is expressed on cortical thymocytes, Langerhans cells, dendritic cells, and a subset of B cells. It has been reported that CD1c is also expressed on mature T cells in a tightly regulated manner. CD1c is involved in antigen-presentation of glycolipids. It may also act in T cells as an immune regulatory molecule.
H1159	PE-CY7 Human CD20 Antibody [2H7]
H2299	PE-CY7 Human CD21 Antibody [B-ly4]
H3349	PE-Cy7 Human CD22 Antibody [HIB22]
H1054	PE-CY7 Human CD235a Antibody [GA-R2 (HIR2)]	CD235a is also known as Glycophorin A (GYPA, GPA, GLPA), Sialoglycoprotein alpha, MN sialoglycoprotein, or PAS-2. CD235b is also known as Glycophorin B (GYPB, GPB, GLPB), Sialoglycoprotein delta, SS-active sialoglycoprotein, or PAS-3. CD235a and CD235b are type I transmembrane sialoglycoproteins expressed on human erythrocytes, erythroid precursor cells, and certain leukemic cell types. CD235a carries blood group M and N antigens, whereas CD235b contains S, s, and U antigens. Glycophorins may play a role in preventing cell agglutination. The antibody against CD235a/b is useful for the identification and characterization of erythrocytes, certain myeloid leukemic cell types, and for studies of erythroid development and infectious diseases inv
H0319	PE-CY7 Human CD24 Antibody [ML5]	CD24, also known as CD24A, signal transducer CD24, small cell lung carcinoma cluster 4 antigen, or BA-1, is a 35-70 kDa glycophosphatidylinositol (GPI)-linked glycoprotein. Its glycosylation pattern is highly variable and cell-type dependent. CD24 is expressed on neutrophils, eosinophils, dendritic cells, neural cells, epithelial cells, muscle cells, and many types of cancer cells. CD24 functions as an adhesion receptor. Several different ligands have been identified for CD24, including CD62P (P-selectin), which is expressed on activated platelets and activated endothelium. CD24 is variably expressed on all B lineage cells, except plasma cells, and can play a role in regulating the activation, proliferation, or differentiation of these cell
H4249	PE-CY7 Human CD25 Antibody [M-A251]	The CD25 antigen is also known as the human low-affinity interleukin-2 receptor α chain (IL-2Rα) and the Tac antigen. The CD25antigen is present on a subset of peripheral blood lymphocytes. Antigen density increases on phytohemagglutinin (PHA)-, concanavalin A (Con A)-, and CD3-activated T lymphocytes; T lymphocytes from mixed lymphocyte cultures; and HTLV-infected T-lymphocyte leukemia lines, for example, HUT-102. Recombinant IL-2 blocks the binding of CD25 to PHA-activated T lymphocytes. CD4+/CD25+ regulatory T cells might directly regulate the function of responsive T cells. The CD25antibody is composed of mouse IgG1 heavy chains and kappa light chains
H2164	PE-CY7 Human CD268/BAFF-R Antibody [11C1]
H4114	PE-CY7 Human CD271/NGFR Antibody [ME20.4]	CD271, also known as p75NTR, TNFRSF16, p75(NTR), Gp80-LNGFR, and NGFR, is a type I transmembrane protein with a MW of 75 kD. It is expressed by many cell types including neurons, Schwann cells, mesenchymal stem/stromal cells, follicular dendritic cells and melanocytes. The extracellular portion contains four TNFR-Cys repeats that form the binding domain for its ligands (NGF, BDNF, NTF3, and NTF4). The intracellular portion of CD271 contains a death domain, which interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9, to promote cell apoptosis, and to regulate cell differentiation and neurogenesis.
H1549	PE-CY7 Human CD272/BTLA Antibody [MIH26]
H0439	PE-CY7 Human CD279/PD-1 Antibody [EH12.2H7]
H4099	PE-CY7 Human CD28 Antibody [CD28.2]	CD28 is a 44 kDa homodimeric transmembrane glycoprotein expressed on most mature T cells, thymocytes, and plasma cells. It acts as a costimulatory receptor, binding to CD80 and CD86 ligands, and plays a crucial role in T cell-B cell interactions. CD28 is believed to initiate and regulate a distinct signal transduction pathway that is separate from those stimulated by the TCR complex. The binding of CD28 to its ligands can also influence immune responses, including the production of IL-2 and changes in intracellular calcium concentrations.
H1759	PE-CY7 Human CD294/CRTH2 Antibody [BM16]	CD294, also known as CRTH2, is a seven-transmembrane protein coupled with heterotrimeric G proteins. CRTH2 is the prostaglandin D2 receptor and is expressed by Th2 cells, eosinophils, and basophils. CD294 prevents the apoptosis of Th2 cells and mediates the chemotaxis of CRTH2 expressing cells to the sites of allergic inflammation, such as the asthmatic lung.
H4279	PE-CY7 Human CD3 Antibody [OKT-3]	CD3ε is one of five polypeptide chains that combine to form the TCR complex. CD3ε is expressed on T lymphocytes, NK-T cels, and to varying degrees on developing thymocytes. CD3 plays roles in TCR signaling, T lymphocyte activation, and antigen recognition.
H4354	PE-Cy7 human CD3 Antibody [UCHT1]
H0229	PE-CY7 Human CD31 Antibody [WM59]	CD31 (PECAM-1), also known as GPIIA' or EndoCAM, is a 130 kDa type I transmembrane glycoprotein belonging to the Ig gene superfamily. It is widely expressed on platelets, monocytes, granulocytes, NK cells, T cell subsets, and in high amounts on endothelial cells. CD31 functions as a vascular endothelial cell adhesion molecule, playing a critical role in the transendothelial migration of leukocytes during inflammatory responses. It is also involved in thrombosis, angiogenesis, and wound healing. The antibody against PECAM-1 binds to an epitope near extracellular domain 2 of CD31. Clone WM59 also cross-reacts with peripheral blood platelets and leukocytes of baboon, and both rhesus and cynomolgus macaque monkeys. The staining intensity of WM5
H1639	PE-CY7 Human CD317 Antibody [RS38E]
H3199	PE-Cy7 Human CD325/N-Cadherin Antibody [8C11]
H0919	PE-CY7 Human CD33 Antibody [WM53]	CD33, also known as Sialic acid-binding Ig-like lectin 3 (Siglec-3), gp67, or p67, is a 67 kDa type I transmembrane glycoprotein expressed on monocytes, activated T cells, myeloid progenitors, and mast cells. CD33 is absent on normal platelets, lymphocytes, erythrocytes, and hematopoietic stem cells. This glycoprotein can reportedly function as a sialic acid-dependent cell adhesion molecule. This function can be modulated by endogenous sialoglycoconjugates when CD33 is expressed on the membrane.
H3649	PE-CY7 Human CD366 Antibody [F38-2E2]	CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells). Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance.
H0859	PE-CY7 Human CD38 Antibody [HIT2]	The CD38 antigen is also known as T10, ADP-ribosyl cyclase 1, and cyclic ADP ribose hydrolase 1. CD38 is a 45 kDa type II single-chain transmembrane glycoprotein present on thymocytes, activated T cells, and terminally differentiated B cells (plasma cells). It is also expressed by monocytes, macrophages, dendritic cells, NK cells, myeloid and erythroid precursors, and some epithelial cells. CD38 functions as an ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose, a Ca²⁺-mobilizing second messenger. This intracellular calcium plays an important role in cell signaling pathways leading to cellular growth, apoptosis, and differentiation. CD38 binds to CD31, contributing to lymphocyte adhesion to endothelial cells.
H3379	PE-CY7 Human CD39 Antibody [A1]	CD39 is an integral membrane protein with two transmembrane domains in humans. It exists as a homotetramer. Expression of CD39 is found on activated lymphocytes, a subset of T cells and B cells, and dendritic cells with weak staining on monocytes and granulocytes. CD39 and CD73 have been found on regulatory T cells, specifically the effector/memory like T cells. CD39 can hydrolyze both nucleoside triphosphates and diphosphates. CD39 is the dominant ecto nucleotidase of vascular and placental trophoblastic tissues and appears to modulate the functional expression of type 2 purinergic (P2) G protein coupled receptors (GPCRs). CD39 has intrinsic ecto-ATPase activity. Expression of CD39 is induced on T cells and increased on B cells as a late a
H0049	PE-CY7 Human CD4 Antibody [L200]	CD4 is a 56 kDa transmembrane glycoprotein expressed on the T-helper/inducer subset of peripheral blood lymphocytes in humans. It is primarily found on CD3-positive, CD8-negative T cells and does not react with B- or NK-cell markers. In baboons, CD4 is expressed on lymphocytes and weakly on monocytes. The distribution of CD4 on lymphocytes is similar between humans and these non-human primates.
H0034	PE-CY7 Human CD4 Antibody [RPA-T4]	CD4 is a 56 kDa transmembrane glycoprotein expressed on the T-helper/inducer subset of normal human peripheral blood lymphocytes. The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex
H0559	PE-CY7 Human CD40 Antibody [5C3]	CD40 is a 45–48 kDa type I transmembrane glycoprotein primarily expressed on B lymphocytes, though it is absent on terminally differentiated B cells. It is also found on endothelial cells, basal epithelial cells, certain epithelial cell carcinomas, follicular dendritic cells, macrophages, fibroblasts, keratinocytes, and CD34+ hematopoietic progenitor cells. CD40 plays a critical role in B-cell growth, proliferation, and differentiation, including immunoglobulin isotype switching. Engagement of CD40, particularly in the presence of IL-4 or costimulation with anti-µ or anti-CD20 antibodies, can promote B-cell proliferation.
H0889	PE-CY7 Human CD41a Antibody [HIP8]	CD41a, also known as Integrin αIIb or Platelet GPIIb, forms a calcium-dependent complex with CD61 (β3 integrin or GPIIIa) that is normally expressed on platelets and megakaryocytes. The CD41/CD61 complex serves as a receptor for fibrinogen, fibronectin, and von Willebrand factor, mediating platelet adhesion and aggregation. Blocking CD41 can completely inhibit ADP-, epinephrine-, and collagen-induced platelet activation, and partially inhibit ristocetin- and thrombin-induced activation.
H4039	PE-CY7 Human CD42b Antibody [HIP1]	CD42b is also known as the Platelet glycoprotein Ib alpha chain that is encoded by the GP1BA gene. CD42b is disulfide bonded to CD42c to form a 170 kDa heterodimer, GPIb. GPIb forms a noncovalent complex with CD42a and CD42d (CD42 complex) that is expressed on platelets and megakaryocytes. The CD42 complex serves as the von Willebrand Factor (vWF) surface receptor involved in the adhesion of platelets to the subendothelium of damaged vascular walls. This antibody inhibits the ristocetin-dependent binding of vWF to platelets and partially inhibits collagen-induced aggregation.
H0094	PE-CY7 Human CD45 Antibody [HI30]	CD45 is encoded by the PTPRC (Protein tyrosine phosphatase receptor type C) gene. CD45, also known as the leukocyte common antigen (LCA), is a member of the protein tyrosine phosphatase (PTP) family. It is present on all human leukocytes including lymphocytes, monocytes, granulocytes, eosinophils, and thymocytes. CD45 is absent from circulating erythrocytes, platelets, or mature erythroid cells of bone marrow and non-hemopoietic tissues.
H0739	PE-CY7 Human CD45RA Antibody [HI100]	CD45RA, a 220 kDa isoform of the human leukocyte common antigen, is expressed on approximately 40–50% of peripheral CD4+ T cells, 50% of peripheral CD8+ T cells, and on a portion of B cells and monocytes. The CD45RA antigen is expressed by naïve and activated T cells. CD45RA-specific antibodies are useful for the study of the suppressor/inducer subpopulation of CD4+ lymphocytes.
H4009	PE-CY7 Human CD45RO Antibody [UCHL1]	CD45RO is a 180 kDa isoform of the CD45 molecule, also known as the Leukocyte Common Antigen. It is a type I transmembrane glycoprotein with cytoplasmic protein tyrosine phosphatase activity involved in signal transduction. Unlike other CD45 isoforms, CD45RO lacks the amino acid sequences encoded by the variable exons A, B, and C. It is expressed on most thymocytes, activated T cells, memory T cells, granulocytes, and monocytes, and on a subset of resting T cells. CD45RO and CD45RA mark largely distinct populations within resting peripheral T cells, demonstrating functional and phenotypic heterogeneity within CD4 and CD8 T cell subsets. CD45RO also interacts with CD22.
H0529	PE-CY7 Human CD49f Antibody [GoH3]	CD49f, also known as the integrin α6 chain, is a ~150 kDa type I transmembrane glycoprotein that belongs to the integrin alpha chain family of extracellular matrix and cell adhesion receptors. The integrin α6 subunit associates with the integrin β1 chain (CD29) to form VLA-6, and with the integrin β4 chain (CD104) to form the integrin α6β4 complex, also known as the laminin and kalinin receptor. CD49f is expressed mainly on T cells, monocytes, platelets, epithelial cells, endothelial cells, perineural cells, and trophoblasts of the placenta. Antibodies against CD49f can block the binding of integrin α6 to laminin P1 and E8 fragments.
H3979	PE-Cy7 Human CD5 Antibody [UCHT2]
H1249	PE-CY7 Human CD54 Antibody [HA58]	CD54, also known as Intercellular Adhesion Molecule 1 (ICAM-1), is an 85-110 kDa type I transmembrane glycoprotein that belongs to the immunoglobulin supergene family. A soluble form of CD54 can also be found in biological fluids. CD54 is expressed on endothelial cells, as well as on both resting (weak) and activated (moderate) lymphocytes and monocytes. It serves as a ligand for LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). The CD54 adhesion molecule plays a key role in inflammatory and immune responses, as well as in neoplasia.
H4264	PE-CY7 Human CD56/NCAM-1 Antibody [B159]	CD56 is a heavily glycosylated adhesion protein that is present on a subpopulation of peripheral blood large granular lymphocytes that demonstrate natural killer activity. CD56 is also expressed on a subset of T cells but is not expressed on myeloid cells, erythrocytes or B cells. This antigen is a pan-NK-cell marker. CD56 is virtually identical to an isoform of the neural cell adhesion molecule (NCAM), a structure mediating homotypic and heterotypic cell-cell interactions.
H3964	PE-CY7 Human CD61 Antibody [VI-PL2]	CD61 is a 105 kDa transmembrane glycoprotein that is also known as integrin β3 and platelet glycoprotein IIIa (GPIIIa or GP3A). It is expressed on platelets, megakaryocytes, osteoclasts and endothelia. Integrin β3 associates with gpIIa (CD41) to form the CD41/CD61 complex which mediates platelet adhesion and aggregation. CD61 also associates with CD51 to form the CD51/CD61 complex (vitronectin receptor). CD61 appears to bind to fibrinogen, fibronectin, vWF, vitronectin, and thrombospondin to mediate cell adhesion.
H0289	PE-Cy7 Human CD62L Antibody [DREG-56]
H1324	PE-CY7 Human CD63 Antibody [H5C6]	CD63 is a 53 kDa, type III lysosomal glycoprotein that belongs to the tetraspan transmembrane 4 superfamily (TM4SF). It is expressed on activated platelets, monocytes, and macrophages, and is also known by several other names, including LIMP, gp55, melanoma-associated antigen ME491, Pltgp40, and LAMP-3. CD63 is widely expressed on the surface and in the cytoplasm of various hematopoietic cells (such as monocytes and macrophages) as well as non-hematopoietic cells (including endothelium, fibroblasts, osteoclasts, and smooth muscle cells). It plays a key role in mediating cellular adhesion and motility.
H0514	PE-CY7 Human CD68 Antibody [Y1/82A]	CD68, also known as Scavenger receptor class D member 1 (SCARD1), Macrosialin, or GP110, is a 110 kDa type I transmembrane glycoprotein primarily localized in cytoplasmic granules of monocytes, macrophages, dendritic cells, granulocytes, myeloid progenitor cells, and reportedly, a subset of CD34-positive hematopoietic bone marrow progenitor cells. CD68 belongs to the sialomucin family and functions as a scavenger receptor, capable of binding and internalizing oxidized low-density lipoproteins (LDL). Antibodies targeting CD68 are commonly used in studies of myeloid cell development and function.
H3994	PE-CY7 Human CD7 Antibody [M-T701]
H1879	PE-CY7 Human CD70 Antibody [113-16]
H0364	PE-CY7 Human CD73 Antibody [AD2]	CD73, also known as ecto-5'-nucleotidase, is a 70 kDa, glycosyl phosphatidylinositol (GPI)-anchored glycoprotein. CD73 is expressed on subsets of T and B lymphocytes, follicular dendritic cells, epithelial cells, endothelial cells and mesenchymal stem cells. Its expression on lymphocytes increases during T and B cell development. CD73 has enzymatic activity and catalyzes the dephosphorylation of adenosine monophosphate (AMP), converting it to adenosine. It has been suggested that CD73 can mediate costimulatory signals in T cell activation and adhesion of lymphocytes to endothelium.
H1999	PE-Cy7 Human CD79b/Igβ Antibody [CB3-1]
H3874	PE-Cy7 Human CD82 Antibody [ASL-24]
H1474	PE-CY7 Human CD83 Antibody [HB15e]	CD83 is a 45 kDa type I transmembrane glycoprotein that belongs to the immunoglobulin (Ig) superfamily. It is composed of a single V-type Ig extracellular domain and a C-terminal cytoplasmic tail. CD83 is primarily expressed on the surface of follicular dendritic cells, circulating dendritic cells, interdigitating dendritic cells in lymphoid tissues, in vitro-generated dendritic cells, and thymic dendritic cells. However, its expression is not limited to dendritic cells; it is also found on some germinal center B cells and certain lymphoblastoid cell lines. While the exact function of CD83 is not fully understood, it is believed to play a role in cell-cell interactions during antigen presentation.
H4024	PE-Cy7 Human CD9 Antibody [HI9a]
H0304	PE-CY7 Human CD90 Antibody [P15F7]	CD90, also known as Thy-1, is a 25-35 kDa glycophosphatidylinositol-anchored membrane glycoprotein of the Ig superfamily. It is expressed on 1-4% of human fetal liver cells, cord blood cells, and bone marrow cells. CD90 is present on a subset of immature CD34+ cells and a distinct subset of mature CD34- cells that are CD3+CD4+. The CD90+CD34+ population is highly enriched for cells capable of long-term culture. The anti-CD90 antibody is useful for enriching high proliferative potential colony-forming cells (HIPP-CFC), which are primitive progenitor cells.
H2044	PE-Cy7 Human CD99 Antibody [3B2/TA8]
H1699	PE-Cy7 Human Galectin-9 Antibody [9M1-3]
H1789	PE-CY7 Human HLA-A2 Antibody [BB7.2]	HLA-A2 is a class I molecule of the major histocompatibility complex (MHC) and part of the highly polymorphic group of cell-surface proteins encoded by the MHC gene locus. It plays a crucial role in the immune response by binding and presenting small antigenic protein fragments to antigen-specific receptors on T cells (TCR). Class I MHC molecules, like HLA-A2, bind peptides derived from intracellular antigens, such as viral and some bacterial antigens, which are recognized by CD8+ T cells. The TCRs recognize these processed peptides bound to the MHC, as well as regions of the MHC molecule itself, while CD4 and CD8 accessory molecules enhance the interaction by binding non-polymorphic regions of the MHC.
H3694	PE-CY7 Human IgD Antibody [IA6-2]	IgD is a member of the immunoglobulin superfamily that exists in type 1-membrane (mIgD) and soluble glycoprotein forms. mIgD is expressed on mature naïve B cells (along with membrane IgM) and serves as a B-cell receptor for antigen (BCR). In response to antigen binding, the mIgD BCR, in association with other signaling molecules including CD79a and CD79b, can transduce activating or tolerizing signals intracellularly into B lymphocytes.
H2269	PE-CY7 Human IgG Fc Antibody [M1310G05]
H1009	PE-CY7 Human IgM Antibody [MHM-88]	IgM is the first immunoglobulin made by B cells in the immune response. Surface IgM is expressed on immature and mature B cells, while IgM heavy (μ) chain is expressed intracellularly in pre-B cells.
H1219	PE-CY7 Human IL-2 Antibody [MQ1-17H12]	Interleukin-2 (IL-2) is a key cytokine involved in immune response and tolerance. It is produced by activated T cells and plays a crucial role in the activation, growth, proliferation, and differentiation of various immune cells, including T and B lymphocytes, LAK cells, NK cells, and monocytes/macrophages. IL-2 exerts its effects through binding to IL-2 receptor complexes, which include the intermediate-affinity IL-2R (comprising IL-2Rβ and γc) and the high-affinity IL-2R (which also includes IL-2Rα, along with IL-2Rβ and γc). IL-2 is essential for the proper functioning of the immune system, particularly in promoting T cell expansion and immune responses.
H0424	PE-Cy7 Human IL-4 Antibody [MP4-25D2]
H2629	PE-CY7 Human NKB1 Antibody [DX9]
H1849	PE-CY7 Human TCR Vα7.2 Antibody [3C10]	The antibody recognizes the Vα7.2 T cell antigen receptor (TCR) α-chain segment which, joined with the Jα33 segment, constitutes an invariant TCR that is a characteristic of the mucosalassociated invariant T cells (MAIT cells). MAIT cells are restricted by a nonpolymorphic class Ib major histocompatibility complex (MHC) molecule, MHC-related molecule 1 (MR1). MAIT cells are present in human blood (1-8% of T cells), mesenteric lymph nodes, liver, and intestinal mucosa. MAIT cells play a role in detecting and fighting off microbial infections
H1489	PE-CY7 Human TCR α/β Antibody [IP26]	TCR α/β is a monomorphic determinant of the α/β T-cell receptor, which is expressed on over 95% of normal peripheral blood CD3+ T cells. The α/β T-cell receptor (TCR) plays a crucial role in recognizing peptides bound to MHC molecules, leading to T-cell activation.
G1594	PE-CY7 Human/Mouse Integrin β7 Antibody [FIB504]	Integrin β7 is a 130 kD glycoprotein also known as integin βp. It is a member of the Ig superfamily. In association with integrin α4 or αE chain, β7 forms α4/β7 or αE/β7 heterodimer. α4/β7 (CD49d/β7, LPAM-1) is expressed on the majority of peripheral lymphocytes, on small subsets of thymocytes, and bone marrow progenitors. LPAM-1 binds to several ligands, VCAM-1, MAdCAM-1 and fibronectin, and is involved in lymphocyte adhesion and some hematopoietic progenitor cells migration. αE/β7 (CD103/β7,αIEL/β7) is expressed on intestinal intraepithelial lymphocytes (IEL), dendritic epidermal T cells, T regulatory cells, a subset of CD8+ T cells in lymph nodes and lamina propria. CD103/β7 complex is thought to play a role in lymphocyte retention via i
H0124	PE-CY7 IFN-gamma Antibody [4S.B3]	IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor and immune interferon that is produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemagglutinin, and other cytokines. IFN gamma is a dimeric protein consisting of two 146 amino acid subunits. IFN gamma is a glycoprotein that exists functionally as a homodimer of approximately 45 kDa. On SDS-PAGE, IFN gamma appears as a combination of 25, 20, and minor 15.5 kDa bands as a result of differential glycosylation. The biological activity of the IFN gamma homodimer is highly species specific. Human IFN gamma does not show cross-reactivity with mouse. IFN gamma exhibits functions such as a
G0949	PE-CY7 IgM Antibody [II/41]	Mouse IgM is an immunoglobulin M antibody that is produced by B cells in response to an antigen. It is the first antibody produced during an immune response and is the largest immunoglobulin in the serum. Mouse IgM is composed of five heavy chains and five light chains, and it is involved in complement activation and agglutination of antigens. It plays a crucial role in the innate immune response and is important for neutralizing pathogens before the adaptive immune response is fully activated. Mouse IgM is widely used in research and diagnostic applications, including ELISA, Western blotting, and immunohistochemistry.
G1909	PE-Cy7 IL-12/IL-23 p40 Antibody [C17.8]
G4084	PE-Cy7 IL-13 Antibody [D16G3]
G0184	PE-Cy7 IL-17A Antibody [G2J2]
G3364	PE-Cy7 IL-17F Antibody [SHLR17]
G1924	PE-CY7 IL-6 Antibody [MQ2-13A5]
G2539	PE-CY7 IRF4 Antibody [3E4]
G0319	PE-CY7 Ki-67 Antibody [SolA15]	Ki-67 is a nuclear protein that is expressed during various stages in the cell cycle, particularly during late G1, S, G2, and M phases. The protein has a forkhead associated domain (FHA) through which it associates with euchromatin at the perichromosomal layer, the centromeric heterochromatin, and the nucleolus. Ki-67 is shown to have a cell cycle dependent topographical distribution with perinucleolar expression at G1, expression in the nuclear matrix at G2, and expression on the chromosomes during M phase. Ki-67 is commonly used as a proliferation marker because it is not detected in G0 cells, but increases steadily from G1 through mitosis. Ki-67 antibodies are useful in establishing the cell growing fraction in neoplasms. In neoplastic t
G0364	PE-CY7 Ly-6A/E/Sca-1 Antibody [D7]	Stem Cell Antigen-1 (Sca-1) is a member of the lymphocyte antigen 6 (Ly-6) family. It is expressed on multipotent hematopoietic stem cells (HSC) and is used as a marker of HSC in mice. Sca-1 is used in combination with lineage depletion antibodies to identify murine HSC. Sca-1 can be found in fetal liver, adult bone marrow, and adult peripheral blood and spleen. Sca-1 may be involved in the regulation of B and T cell activation.
G2524	PE-Cy7 MHC Class I/H-2Db Antibody [28-14-8]
G0439	PE-Cy7 Mouse CD107a Antibody [1D4B]
G4114	PE-CY7 Mouse CD138 Antibody [281-2]	CD138 (Syndecan-1) is a transmembrane proteoglycan containing both heparan sulfate and chondroitin sulfate chains. It binds to components of the extracellular matrix and plays a critical role in cell adhesion, proliferation, and signaling. CD138 is predominantly expressed on epithelial cells, where its presence is associated with normal epithelial architecture. It is also expressed on B lymphocytes during specific stages of differentiation, including precursor B cells in the bone marrow and antibody-secreting plasma cells, but is absent on mature peripheral B cells. This expression pattern implicates CD138 in B cell–matrix interactions. Its expression is regulated during embryonic development and is subject to tissue-specific structural pol
G0979	PE-Cy7 Mouse CD146 Antibody [ME-9F1]
G0649	PE-CY7 Mouse CD150/SLAM Antibody [TC15-12F12.2]	CD150 is a 75-95 kD member of the immunoglobulin superfamily, also known as SLAM (signaling lymphocyte activation molecule) or IPO-3. CD150, a single chain type I transmembrane molecule, is expressed on thymocytes, T cell subsets, B cells, dendritic cells, and endothelial cells. The expression is upregulated upon activation. CD150 expression has been shown to be maintained on Th1 but not Th2 clones. T regulatory cells express a relatively high level of CD150. Antibodies against CD150 have been shown to augment IFN-γ production by Th1 cells, especially when co-stimulated through the TCR. CD150 associates with the src homology 2-domain-containing protein tyrosine phosphatase SHP-2, and this association is thought to be involved in signal tran
G4234	PE-CY7 Mouse CD16/CD32 Antibody [2.4G2]	CD16 and CD32 are expressed on B cells, monocytes/macrophages, NK cells, granulocytes, mast cells, and dendritic cells. These receptors bind to the Fc portion of antibody-antigen complexes and play a role in adaptive immune responses.
G2989	PE-CY7 Mouse CD163 Antibody [S15049I]
G3004	PE-CY7 Mouse CD172a/SIRPα Antibody [P84]
G1084	PE-CY7 Mouse CD185 Antibody [2G8]	The Rat Anti-Mouse CD185 (CXCR5) monoclonal antibody specifically binds to the mouse C-X-C Chemokine Receptor type 5, CXCR5. CXCR5 is also known as CD185, BLR1, NLR and MDR15. CXCR5 is a seven-transmembrane, G-protein-coupled receptor that is specific for the CXC chemokine, CXCL13/BLC/BCA-1. The expression of CXCR5 has been detected in spleen, lymph nodes, tonsils, brain, bone marrow, T cells, B cells, cerebrum, cerebellum, hippcampus and pituitary. In mouse spleen, CXCR5 was strictly expressed by mature B cells and a small subset of T lymphocytes. CXCR5 plays a role in directing the migration of B and T cells to B cell follicles with the spleen and certain other lymphoid tissues. The immunogen used to generate 2G8 hybridoma was a recombina
G4384	PE-CY7 Mouse CD19 Antibody [1D3]	CD19, a B lymphocyte-lineage differentiation antigen and a 95-kDa transmembrane glycoprotein, is a member of the immunoglobulin superfamily and is expressed throughout B-lymphocyte development from the pro-B cell stage through mature B cells. Terminally differentiated plasma cells do not express CD19. On mature B cells, CD19 associates with CD21 (CR-2) and CD81 (TAPA-1), forming a multimolecular complex that synergizes with surface immunoglobulin to promote cellular activation. Studies in CD19-deficient mice suggest that the level of CD19 expression influences the generation and maturation of B cells in both bone marrow and peripheral tissues. B-1 lineage B cells, also called CD5+ B cells, are drastically reduced or absent in CD19-deficient
G1549	PE-Cy7 Mouse CD205/DEC-205 Antibody [NLDC-145]
G4204	PE-CY7 Mouse CD25/IL-2Rα Antibody [PC61.5]	Interleukin-2 receptor alpha (IL-2Rα), also known as CD25, Ly-43, p55, or Tac, is the 55 kDa ligand-binding subunit of the interleukin-2 receptor. IL-2Rα is expressed on activated mature T and B lymphocytes, thymocyte subsets, pre-B cells, and T regulatory cells. IL-2Rα plays roles in lymphocyte differentiation, activation, and proliferation. Alone, IL-2Rα binds IL-2 with relatively low affinity; however, when IL-2Rα associates with IL-2Rβ (CD122) and the common gamma chain (CD132), the complex binds IL-2 with high affinity.
G2869	PE-Cy7 Mouse CD26 Antibody [H194-112]
G2239	PE-Cy7 Mouse CD301b/MGL2 Antibody [URA-1]
G1249	PE-CY7 Mouse CD357/GITR Antibody [DTA-1]	CD357, also known as GITR (Glucocorticoid-induced Tumor Necrosis Factor Receptor family-Related), is a 66-70 kDa homodimer glycoprotein that belongs to the TNF receptor superfamily. It is also referred to as TNFRSF18. GITR expression was first identified in T lymphocytes treated with dexamethasone, a glucocorticoid. In normal naive mice, GITR is expressed at moderate levels on CD25-positive/CD4-positive/CD8a-negative thymocytes and on CD25-positive/CD4-positive/CD45RB-low splenocytes. It is also expressed at low levels on splenic CD25-negative/CD4-positive/CD45RB-low T lymphocytes, B lymphocytes, macrophages, and dendritic cells. GITR expression is upregulated upon activation of T and B lymphocytes. As a costimulatory receptor, GITR plays a
G0844	PE-CY7 Mouse CD38 Antibody [90]	CD38 is a 45 kD type II transmembrane glycoprotein also known as T10. It is an ADP-ribosyl hydrolase expressed at variable levels on hematopoietic cells and in some non-hematopoietic tissues (such as brain, muscle, and kidney). In humans, it is expressed at high levels on plasma cells and activated T and B cells, natural killer (NK) lymphocytes, myeloblasts, and erythroblasts. By functioning as both a cyclase and a hydrolase, CD38 mediates lymphocyte activation, adhesion, and the metabolism of cADPR and NAADP. CD31 is the ligand of CD38.
G4144	PE-CY7 Mouse CD4 Antibody [GK1.5]	The CD4 antigen is a 55 kDa cell surface type I membrane glycoprotein belonging to the immunoglobulin superfamily. CD4 acts as a co-receptor which, in cooperation with the T cell receptor (TCR), interacts with class II MHC molecules displayed by antigen-presenting cells (APC). CD4 is expressed by the majority of thymocytes, most helper T cells, a subset of NK-T cells, and weakly by dendritic cells and macrophages. CD4 plays an important role in the development of T cells and is required for mature T cells to function optimally.
G4834	PE-Cy7 Mouse CD40L Antibody [MR-1]
G0859	PE-CY7 Mouse CD41 Antibody [MWReg30]	CD41 is a transmembrane glycoprotein that is encoded by Itga2b. CD41 associates with Integrin β3 chain (gpIIIa or CD61) to form the gpIIb/IIIa (CD41/CD61) complex. CD41/CD61 is expressed on platelets, megakaryocytes, and early hematopoietic progenitors. The integrin complex binds to fibrinogen, fibronectin, vitronectin, von Willebrand factor, and thrombospondin. It is important for platelet adhesion and aggregation, and it may play a role in osteolytic tumor metastasis.
G1039	PE-Cy7 Mouse CD43 Activation-Associated Glycoform Antibody [1B11]
G0544	PE-CY7 Mouse CD49b Antibody [HMα2]	CD49b is a 150 kD glycoprotein, also known as α2 integrin, VLA-2 α chain, Integrin α2 chain, and HMα2. It is a member of the integrin family, expressed on NK cells, a subset of splenic CD4+ T cells, NK-T cells, intestinal intraepithelial and lamina propria lymphocytes, epithelial cells, and platelets. By associating with CD29 (integrin β1 subunit), CD49b forms the VLA-2 (integrin α2β1 ) complex. It plays a critical role in both adhesion and lymphocyte activation. The primary ligands for CD49b are collagen, laminin, and fibronectin.
G1114	PE-CY7 Mouse CD54 Antibody [YN1/1.7.4]	CD54 is a 90 kD immunoglobulin superfamily member also known as ICAM-1 and Ly-47. It is expressed on activated endothelial cells, high endothelial venules (HEV), T and B cells, monocytes/ macrophages, granulocytes, and dendritic cells. CD54 is an important intracellular adhesion molecule that participates in T cell-T cell, T cell-B cell, and T cell-target cell interactions via binding of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). CD54 has also been shown to be involved in lymphocyte trafficking, making it an important molecule in many immune reactions and inflammation. CD54 is also a receptor for rhinovirus. Antibodies against CD54 can block its interaction with LFA-1 and Mac-1, thereby inhibiting cell-cell adhesion, impairing antigen prese
G2464	PE-Cy7 Mouse CD55 Antibody [RIKO-3]
G2944	PE-CY7 Mouse CD64 Antibody [X54-5/7.1]	CD64 is a 72 kD single chain type I glycoprotein also known as FcγRI and FcRI. CD64 is a member of the immunoglobulin superfamily and is expressed on monocytes/macrophages, dendritic cells, and mast cells. The expression can be upregulated by IFN-γ stimulation. CD64 binds IgG immune complex. It plays a role in antigen capture, phagocytosis of IgG/antigen complexes, and antibody-dependent cellular cytotoxicity (ADCC).
G1324	PE-Cy7 Mouse CD83 Antibody [Michel-19]
G4414	PE-CY7 Mouse CD86 Antibody [GL1]	CD86, along with CD80, is a member of the B7 family of costimulatory molecules and plays a crucial role in T cell activation and immune response regulation. CD86 is expressed at low levels on B cells, macrophages, and dendritic cells, and its expression is upregulated on B cells through various stimuli, including the BCR complex, CD40, and certain cytokine receptors. As a type I membrane protein and member of the immunoglobulin superfamily, CD86 serves as a ligand for the T cell surface proteins CD28 and CTLA-4 (CD152). The interaction between CD86 and CD28 provides a costimulatory signal essential for T cell activation during antigen presentation, while binding with CTLA-4 negatively regulates T cell activation, diminishing the immune resp
G1489	PE-Cy7 Mouse CD88/C5aR Antibody [20/70]
G1054	PE-CY7 Mouse CX3CR1 Antibody [SA011F11]	CX3CR1 is a 40 kD, G-protein coupled receptor, with seven transmembrane regions. CX3CR1 is expressed by resident and alternatively activated macrophages (M2), a subset of monocytes, dendritic cells (DCs), NK cells, a subset of memory T cells, and mast cells. CX3CR1 is involved in cell recruitment during inflammation and participates in cell adhesion and extravasation from blood vessels. Its ligand is CX3CL1, also known as fractalkine or neurotactin. CX3CR1 is also a coreceptor for HIV1 and variations in this gene leads to increased susceptibility to HIV. In the brain, it is expressed by glial cells, which interact with CX3CL1 expressed by neurons.
G4369	PE-CY7 Mouse CXCR3 Antibody [CXCR3-173]	CXCR3, also known as CD183, is a 38 kDa chemokine receptor for CXCL9 (MIG), CXCL10 (IP-10), and CXCL11 (ITAC). CXCR3 is expressed primarily on activated T cells, NK cells, as well as some epithelial and endothelial cells. CXCR3 mediates leukocyte trafficking. Binding of chemokine ligands to CXCR3 induces various cellular responses, including integrin activation, cytoskeletal changes, and chemotactic migration. An antibody targeting CXCR3 binds to the receptor and inhibits its interaction with CXCL10 and CXCL11, but not CXCL9.
G1804	PE-CY7 Mouse H-2Kb Antibody [AF6-88.5]	H-2Kb is a mouse MHC class I alloantigen expressed on all nucleated cells of mice with the H-2^b haplotype. It plays a key role in presenting endogenous peptides to CD8+ T cells, enabling immune surveillance and cytotoxic T cell responses.
G1504	PE-CY7 Mouse I-A[b] Antibody [AF6-120.1]	I-A[b] is a major histocompatibility complex (MHC) class II molecule found on antigen-presenting cells such as B cells, dendritic cells, and macrophages. It presents peptides derived from extracellular proteins to CD4+ T helper cells, playing a critical role in initiating and regulating adaptive immune responses
G4189	PE-CY7 Mouse IgG1 isotype control Antibody [MOPC-21]	Mouse IgG1 isotype control is a mouse myeloma protein. It was selected as an isotype control following screening for low background on a variety of mouse and human tissues.
G3184	PE-CY7 Mouse IgG2b Antibody [RMG2b-1]
G0784	PE-CY7 Mouse IL-10 Antibody [JES5-16E3]	IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. D
G4219	PE-CY7 Mouse IL-4 Antibody [11B11]	IL-4 (interleukin-4) is a multifunctional 14 kDa cytokine. IL-4 is mainly produced by activated Th2 and NK cells, with smaller contributions from mast cells and basophils. It signals via the IL-4Rα receptor. Once bound to its receptor, IL-4 promotes the proliferation of activated B and T cells and drives B cell differentiation into plasma cells. It also facilitates class switching to IgE in B cells and enhances MHC class II expression, while suppressing Th1 cell development, macrophage activity, IFNγ production, and IL-12 release by dendritic cells. IL-4, like other cytokines associated with Th2 responses, contributes to airway inflammation commonly seen in allergic asthma.
G4324	PE-CY7 Mouse LAG-3 Antibody [C9B7W]
G1639	PE-Cy7 Mouse LAP/TGF-β1 Antibody [TW7-16B4]
G4309	PE-CY7 Mouse LFA-1α/CD11a Antibody [M17/4]	LFA-1α (lymphocyte function-associated antigen 1 alpha), also known as integrin alpha L chain and CD11a, pairs with CD18 to form LFA-1, a 180 kDa integrin glycoprotein belonging to the integrin family. LFA-1 is expressed on the surface of all leukocytes, including lymphocytes, monocytes, macrophages, and granulocytes. It plays a central role in leukocyte intercellular adhesion through interactions with its ligands ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50), and also contributes to lymphocyte costimulatory signaling.
G4429	PE-CY7 Mouse Ly6G Antibody [1A8]	Lymphocyte antigen 6 complex, locus G (Ly-6G), is a 21–25 kDa GPI-anchored protein expressed primarily on peripheral granulocytes and highly specific for neutrophils. Ly-6G serves as a robust marker for neutrophil identification and depletion in mice. Ly-6G modulates neutrophil migration and recruitment to sites of inflammation via interaction with β2 integrins. Its downregulation is associated with age-related functional decline in neutrophils.
G4249	PE-CY7 Mouse NK1.1 Antibody [PK136]	NK1.1, also known as CD161b/CD161c, KLRB1, NKR-P1A, and Ly-55, is a type II integral membrane glycoprotein with a C-type lectin domain and is encoded by the Klrb1c/NKR-P1C gene. NK1.1 plays roles in NK cell activation and differentiation, IFN-γ production, cytotoxic granule release, and is thought to be involved in the generation of Th2 cells. NK1.1 is predominantly expressed as a disulfide-linked homodimer on NK cells; however, it is also expressed on NK-T cells, a rare population of T lymphocytes. NK1.1 is only expressed by C57BL/6, FVB/N, and NZB strains of mice and not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129 strains.
G4804	PE-Cy7 Mouse OX40 Antibody [OX-86]
G4264	PE-CY7 Mouse PD-L1 Antibody [10F.9G2]	PD-L1 (programmed death ligand 1), also known as B7-H1 or CD274, is a 40 kDa type I transmembrane protein that belongs to the B7 family of the immunoglobulin superfamily. PD-L1 is expressed on T lymphocytes, B lymphocytes, NK cells, dendritic cells, as well as IFNγ-stimulated monocytes, epithelial cells, and endothelial cells. PD-L1 binds to its receptor, PD-1, found on CD4 and CD8 thymocytes as well as activated T and B lymphocytes and myeloid cells. Engagement of PD-L1 with PD-1 leads to inhibition of TCR-mediated T cell proliferation and cytokine production. PD-L1 is thought to play an important role in tumor immune evasion. Induced PD-L1 expression is common in many tumors and results in increased resistance of tumor cells to CD8 T cell
G1669	PE-CY7 Mouse TCR Vα2 Antibody [B20.1]	TCR Vα2 is a distinct T-cell receptor (TCR) subfamily found in mice with the a, b, and c haplotypes. The TCR α chain complexes with the TCR β chain in 95% of T cells, forming the T cell receptor (α/β TCR), while the remaining 5% of T cells express gamma (γ) and delta (δ) chains (γ/δ TCR). TCR Vα2 represents a specific variant of the TCR α chain that plays a role in antigen recognition and is useful in the study of T-cell function and immune responses in mice with these specific haplotypes.
G4354	PE-CY7 Mouse Ter-119 Antibody [TER-119]	TER-119 is a lineage marker for erythroid cells from early proerythroblast to mature erythrocyte stages in adult blood, spleen, and bone marrow. It is also present in yolk sac, and fetal and newborn liver. The TER-119 antigen is not expressed by cells of earlier erythroid development at BFU-e (blast-forming unit erythroid) stage or CFU-e (colony-forming unit erythroid) stage.
G4894	PE-Cy7 mouse TIGIT Antibody [1G9]
G1759	PE-CY7 Mouse Tim-4 Antibody [RMT4-54]
G4669	PE-Cy7 mouse/human CD11b Antibody [M1/70]
G2029	PE-CY7 Mouse/rat CD81 Antibody [Eat-2]	CD81 is a 26 kD non-glycosylated member of the tetraspanin superfamily (TM4SF), also known as TAPA-1. CD81 is expressed on T and B cells, NK cells, dendritic cells, thymocytes, endothelial cells, and fibroblasts. CD81 induces B cell adhesion via the VLA-4 integrin and has been shown to play a role in early T cell development. CD81 associates with several other cell-surface proteins in a multimolecular complex, including CD19, CD21, CD20, CD37, CD53, and CD82 in B cells, and CD4, CD8 and CD82 in T cells.
G3889	PE-CY7 Phospho-Zap-70 (Tyr319)/Syk (Tyr352) Antibody [L15L21]
G1294	PE-CY7 Podoplanin Antibody [L7B2]	Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin type-1 glycoprotein with a 40-43 kDa molecular weight. Podoplanin is expressed in many tumors and normal cells, especially lymphatic epithelial cells and follicular DCs. Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. Podoplanin appears to serve as a ligand for CLEC-2 and expression is positively correlated with tumors expressing greater invasive and metastatic potential. Podoplanin is directly involved in cell migration, aids metastases formation and tumor cell invasion of tissue. Further, it has also been determined that
G4294	PE-Cy7 Rat IgG2a isotype control Antibody [2A3]
G0634	PE-Cy7 Rat IgG2a κ Isotype Control Antibody [eBR2a]
G0889	PE-Cy7 Rat IgG2b kappa Isotype Control Antibody [eB149/10H5]
G0619	PE-CY7 T-bet Antibody [B2D24]	T-bet, also known as TBX21, is a T-cell specific transcription factor containing a single T-box DNA-binding domain. It controls the expression of the TH1 cytokine, interferon-gamma. Both Th1 and Th17 cells are crucial in immune regulation and autoimmune disease development. T-bet initiates Th1 lineage development from naive Th precursor cells and directs T cell differentiation to Th1 versus Th17. T-bet is cooperating with Stat4 (signal tranducer and activator of transcription 4) in programming chromatin architecture for Th1 gene expression. Genetic variations in T-bet are associated with susceptibility to aspirin-induced asthma and nasal polyps.
G4024	PE-CY7 TCF1/TCF7 Antibody [E19C1]	LEF1 and TCF are members of the high mobility group (HMG) DNA-binding protein family of transcription factors that consists of the following: Lymphoid Enhancer Factor 1 (LEF1), T Cell Factor 1 (TCF1/TCF7), TCF3/TCF7L1, and TCF4/TCF7L2. LEF1 and TCF1/TCF7 were originally identified as important factors that regulate early lymphoid development and act downstream in Wnt signaling. LEF1 and TCF bind to Wnt response elements to provide docking sites for β-catenin, which translocates to the nucleus to promote the transcription of target genes upon activation of Wnt signaling. LEF1 and TCF are dynamically expressed during development and aberrant activation of the Wnt signaling pathway is involved in many types of cancers, including colon cancer.
H3274	PE-Cy7 TCR Vδ1 Antibody [TS8.2]
G0289	PE-CY7 TCR-β Antibody [H57-597]	The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system c
H1309	PE-CY7 TIGIT Antibody [MBSA43]
G3424	PE-CY7 TLR4/MD-2 Complex Antibody [MTS510]	MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e.g., human MD-2 transfected into mouse cells can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4.
H0349	PE-CY7 TNF-α Antibody [MAb11]	TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is mainly secreted by macrophages and binds to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. It exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice suggested the neuroprotective function of TNF alpha, and it has been observed to cause tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to
G0334	PE-Cy7 TNF-α Antibody [MP6-XT22]
F3134	PEA3 Antibody [L14H15]	ETV4,Pea3
E3301	Peanut hull Extract	Peanut Hull Extract is the extract of peanut shell, which contains abundant flavonoids in the form of two element, which can be used to develop natural yellow pigment.
E3302	Peanut seed coat Extract	Peanut Seed Coat Extract is the extract of peanut coat, which contains abundant bioactive components and has physiological effects on preventing and treating chemotherapy-induced thrombocytopenia.
E1050	PEAQX	PEAQX (NVP-AAM077) is an effective and orally available human NMDA antagonist, which shows preference in excess of 100-fold for hNMDA 1A/2A (IC50=of 270 nM) over hNMDA 1A/2B receptors (IC50=29,600 nM).
E3868	Pearl Extract	Pearl Extract is extracted from pearl, which inhibits endothelin, thereby safely and effectively lightening the skin by antagonising endothelin.
E1877	Pebezertinib	Pebezertinib is a central nervous system (CNS)-penetrant, wild-type EGFR-sparing, covalent inhibitor of epidermal growth factor receptor (EGFR) exon 20 insertion (Ex20ins) with an IC50 of 7-78 nM. It also exhibits a potent anti-tumor efficacy.
A5649	PEBP1 Rabbit Recombinant mAb	PEBP1 Rabbit Recombinant mAb detects endogenous level of total PEBP1.
E2955	Pectin	Pectin is a heteropolysaccharide, derived from the cell wall of higher plants. It involves in the formation of nanoparticles as a delivery vehicle of agents. It also acts as an adsorbent, a broad-spectrum antimicrobial agent that binds to bacteria toxins and other irritants in the intestinal mucosa, relieves irritated mucosa.
S3255	Pectolinarigenin	Pectolinarigenin, an active anti-inflammatory ingredient in Cirsium chanroenicum, is a dual inhibitor of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX).
S9054	Pectolinarin	Pectolinarin is a major compound in Cirsium setidens with anti-inflammatory activity. Pectolinarin inhibits secretion of IL-6 and IL-8, as well as the production of PGE2 and NO. Pectolinarin induces apoptosis via inactivation of the PI3K/Akt pathway.
S9501	Pedunculoside	Pedunculoside is a novel triterpene saponin extracted from the dried barks of Ilex rotunda Thunb, showing lipid-lowering effects.
S7650	Peficitinib	Peficitinib is an orally bioavailable JAK inhibitor. Phase 3.
E7229	Pefloxacin	Pefloxacin is a an antibacterial agent and prevents bacterial DNA replication by inhibiting DNA gyrase (topoisomerse) Target: DNA gyrase Pefloxacin is a synthetic chemotherapeutic agent used to treat severe and life-threatening bacterial infections.
S1855	Pefloxacin Mesylate	Pefloxacin Mesylate(Pefloxacinium mesylate) is a synthetic chemotherapeutic agent and an antibacterial agent with IC50 of 6.7 nM.
S4119	Pefloxacin Mesylate Dihydrate	Pefloxacin Mesylate Dihydrate (1589 RB,Pefloxacinium mesylate dihydrate) is the third generation of fluoroquinolone class of antibacterials, which inhibits Topoisomerase II activity and DNA replication.
S6704	PEG300	PEG300 (Polyethylene glycol 300) is a water-miscible polyether widely used in biochemistry, structural biology, and medicine in addition to pharmaceutical and chemical industries. It serves as a kind of solubilizer, excipient, lubricant, and chemical reagent. PEG300 helps in the formation of hydrogels in situ upon mixing with silk. These PEG–silk hydrogels are of interest for many biomedical applications, such as anti-fouling and anti-adhesion.
S6705	PEG400	PEG400b (Polyethylene glycol 400) is a commonly used co-solvent used in a variety of pharmaceutical formulations. It acts as a good solubilizer and surfactant and has the potential to improve the bioavailability of drugs. PEG400 significantly accelerates the metabolism of baicalein and increases the penetration of BG and B6G in Caco‐2 cells.
S9281	Peimine	Peimine (Verticine, Wanpeinine A) is a major biologically active component of Fritillaria ussuriensis, exhibits anti-inflammatory and pain suppression properties at the cellular level.
S9148	Peiminine	Peiminine (Verticinone, Zhebeinone, Raddeanine), a biologically active component extracted from Fritillaria walujewii Regel, has been reported to have potent anti-inflammatory, antitussive, and expectorant effects. It induces autophagic cell death thus represses colorectal carcinoma tumor growth.
S7853	Pelabresib (CPI-0610)	Pelabresib (CPI-0610) is a potent and selective benzoisoxazoloazepine BET bromodomain inhibitor with an IC50 of 39 nM for BRD4-BD1 in TR-FRET assay and currently undergoing human clinical trials for hematological malignancies. CPI-0610 inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes.
E3623	Pelargonium hortorum Extract	Pelargonium Hortorum Extract is extracted from Pelargonium hortorum L.H. Bailey. Pelargonium cultivars have been reported as metal hyperaccumulators, with the ability to acidify soil pH. Pelargonium hortroum has the ability to accumulate Pb in shoots.
S1392	Pelitinib (EKB-569)	Pelitinib (EKB-569) is a potent irreversible EGFR inhibitor with IC50 of 38.5 nM. Pelitinib (EKB-569) also slightly inhibits Src, MEK/ERK and ErbB2 with IC50s of 282 nM, 800 nM and 1255 nM, respectively. Phase2.
F3720	Pellino 1 Antibody [H22B1]	Pellino 1,Pellino-1
A5729	PELP1 Rabbit Recombinant mAb	PELP1 Rabbit Recombinant mAb detects endogenous levels of total PELP1.
E2876	pemafibrate	Pemafibrate(K-877) is a selective agonist of peroxisome proliferator-activated receptor (PPAR) α with an IC50 of 10 µM.
A2005	Pembrolizumab (anti-PD-1)	Pembrolizumab (anti-PD-1) is a potent, highly selective, fully humanized immunoglobulin (Ig) G4-kappa monoclonal antibody against PD-1 with potential immune checkpoint inhibitory and antineoplastic activities. MW : 146.286 KD.
S5971	Pemetrexed	Pemetrexed (LY231514) is a novel antifolate and antimetabolite for thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.
E4818	Pemetrexed (disodium heptahydrate)	Pemetrexed (disodium heptahydrate) is a folate antimetabolite that inhibits thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyltransferase. It also induces apoptosis and cell-cycle arrest in non-small-cell lung cancer carrying an EGFR exon 19 deletion.
S1135	Pemetrexed disodium	Pemetrexed disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with K_i of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.
S7785	Pemetrexed Disodium Hydrate	Pemetrexed Disodium Hydrate (LY-231514) is a novel antifolate and antimetabolite for TS, DHFR and GARFT with K_i of 1.3 nM, 7.2 nM and 65 nM, respectively. Pemetrexed Disodium Hydrate stimulates autophagy and apoptosis.
S0088	Pemigatinib	Pemigatinib is an orally active and selective inhibitor of FGFR with IC50 of 0.4 nM, 0.5 nM, 1.2 nM and 30 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively. Pemigatinib has the potential for cholangiocarcinoma.
S4008	Pemirolast potassium	Pemirolast potassium (BMY26517) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent.
S5725	Pempidine	Pempidine (Pyrilene, Perolysen, 1,2,2,6,6-Pentamethylpiperidine) is a long-acting ganglion-blocking compound.
S8664	Pemrametostat (GSK3326595)	Pemrametostat (GSK3326595, EPZ015938) is an orally active, potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) and potently inhibits tumor growth in vitro and in vivo in animal models.
F1441	PEN2 Antibody [B8C20]
S9470	Penbutolol Sulfate	Penbutolol sulfate ((-)-Terbuclomine) is an effective beta-adrenergic receptor blocker and diuretic that is used as an antihypertensive agent.
S4184	Penciclovir	Penciclovir (BRL-39123, VSA 671,NSC-759624) is a purine acyclic nucleoside analogue with potent antiviral activity.
E7305	Penconazole	Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats.
S4151	Penfluridol	Penfluridol (TLP-607,R-16341) is a highly potent, first generation diphenylbutylpiperidine antipsychotic.
S1853	Penicillamine	Penicillamine (Dimethyl Cysteine) is used as an antirheumatic and as a chelating agent in Wilson’s disease.
E7320	Penicillic acid	Penicillic acid is a polyketide mycotoxin produced by several species of Aspergillus and Penicillium. Penicillic acid exhibits cytotoxicity in rat alveolar macrophages (AM) in vitro. Penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8.
E6075	Penicillin G benzathine tetrahydrate	Penicillin G benzathine tetrahydrate (Benzathine benzylpenicillin tetrahydrate) is a long-acting beta-lactam antibiotic effective against many bacterial infections such as impetigo.
S5515	Penicillin G Procaine	Procaine benzylpenicillin (Procaine benzylpenicillin,PGP), also known as Procaine benzylpenicillin, is an antibiotic useful for the treatment of a number of bacterial infections.
S4160	Penicillin G Sodium	Penicillin G Sodium (Benzylpenicillin) is a β-lactam antibiotic produced by Penicillin spp.
S3650	Penicillin V potassium salt	Phenoxymethylpenicillin, also known as penicillin V, is an antibiotic useful for the treatment of a number of bacterial infections. It acts by inhibiting the biosynthesis of cell-wall peptidoglycan.
E2894	Penicillin-Streptomycin	Penicillin-Streptomycin is used to prevent microbial contamination of cell culture during long-term in vitro cell culture maintenance. 100× solution stabilized with 10,000 units penicillin and 10 milligrams streptomycin per milliliter, suitable for cell culture applications.
E0674	Pennogenin 3-O-β-chacotrioside	Pennogenin 3-O-beta-chacotrioside, an active component isolated from Paris polyphylla, modulates autophagy via increasing the expressions of autophagy-related proteins LC3 and Beclin-1, and posesses anti-colorectal cancer activity.
S6234	Pentadecanoic acid	Pentadecanoic acid is a saturated fatty acid of exogenous (primarily ruminant) origin. It also has a role as a plant metabolite, a food component, a Daphnia magna metabolite, a human blood serum metabolite and an algal metabolite.
E4864	Pentamidine	Pentamidine (MP-601205) is an aromatic diamidine drug, an antagonist of TLR4.It also inhibits PI3K/AKT signaling pathway and reduce the expression of MMP-2 and MMP-9. It exhibits anti- protozoal, anti-inflammatory, and anti-tumor activities and is used as an agent for treating African trypanosomiasis, antimony resistant leishmaniasis and Pneumocystis carinii pneumonia.
S4007	Pentamidine isethionate	Pentamidine is an inhibitor of PRL Phosphatases and also inhibits synthesis of DNA, RNA and protein.
S5746	pentetate calcium trisodium hydrate	pentetate calcium trisodium hydrate (Ca-DTPA) is an iron chelating agent.
S4824	Pentetic Acid	Pentetic Acid (Diethylenetriaminepentaacetic acid, DTPA, Acidum penteticum, Detapac, Detarex) is an aminopolycarboxylic acid that is used similar to EDTA, sequestering metal ions.
E3217	Penthorum Chinense Pursh Extract	Penthorum Chinense Pursh Extract is extrcated from Penthorum Chinense Pursh, which is used in the treatment of traumatic injury, edema, and liver diseases.
S3500	Pentosan Polysulfate Sodium	Pentosan Polysulfate Sodium (PPS, Elmiron) is an orally bioavailable, semi-synthetic medication with anti-inflammatory and pro-chondrogenic properties. Pentosan Polysulfate Sodium also exhibits anti-HIV-1 activity.
S9521	Pentostatin	Pentostatin(CI-825,Deoxycoformycin) is a potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.
S4345	Pentoxifylline	Pentoxifylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF and leukotriene synthesis, and reduces inflammation and innate immunity.
S4143	Pentoxyverine Citrate	Pentoxyverine Citrate (Carbetapentane) is an antitussive (cough suppressant) commonly used for cough associated with illnesses like common cold.
F2748	Pentraxin 3/PTX3 Antibody [M10M8]
S4587	Pentylenetetrazol	Pentylenetetrazol (Pentylenetetrazole, Metrazole, pentetrazol, pentamethylenetetrazol, Corazol, Cardiazol, PTZ) displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GABA(A) receptor antagonist.Pentylenetetrazol can be used to induce animal models of (Acute or Chronic) Epilepsy.
S6788	PEO-IAA	PEO-IAA (2-(1H-Indol-3-yl)-4-oxo-4-phenyl-butyric acid) is a novel potent auxin antagonist that binds to transport inhibitor response 1/auxin signaling F-box proteins (TIR1/AFBs). PEO-IAA suppresses not only the expression of an auxin-responsive ZmSAUR2 gene, but also gravitropic curvature.
E3490	Peony flower Extract	Peony Flower Extract is extracted from the flowers of Paeonia, which is used in the treatment of various metabolic diseases.
P1165	Pep2m, myristoylated (TFA)	Pep2m, myristoylated (TFA) is a cell-permeable peptide, which can disrupt the protein kinase ζ (PKMζ) downstream targets, N-ethylmaleimide-sensitive factor/glutamate receptor subunit 2 (NSF/GluR2) interactions.
A2361	Pepinemab (Anti-SEMA4D / CD100)	Pepinemab (Anti-SEMA4D / CD100) is a human monoclonal antibody against SEMA4D, a signalling protein 4D (SEMA4D), which is a regulator of neuronal development and plays a role in a variety of cellular processes. MW : 145.5 kD.
S7381	Pepstatin A	Pepstatin A (Pepstatin) is a potent aspartic protease inhibitor, and also inhibits HIV replication. Pepstatin A is also an inhibitor of cathepsins D and cathepsins E. Pepstatin A inhibits autophagy by suppressing lysosomal proteases.
E6410	Peptide 4	Peptide 4 is a complex synthetic peptide molecule commonly used as a research chemical or therapeutic agent due to its potential to mimic biological peptides and modulate specific molecular targets.
P1125	Peptide YY (3-36) (human)	Peptide YY (3-36) (human) is an endogenous appetite suppressing peptide. Peptide YY (PYY) (3-36), Human, a neuropeptide Y (NPY) Y2 receptor agonist, is a powerful inhibitor of intestinal secretion[1].
P1126	Peptide YY (human)	Peptide YY (PYY) is a gut hormone that regulates appetite and inhibits pancreatic secretion. Peptide YY (PYY) can mediate its effects through the Neuropeptide Y receptors.
S2716	Peramivir Trihydrate	Peramivir Trihydrate (BCX-1812, RWJ-270201, S-021812) is a trihydrate of the anti-infection agent peramivir which is a transition-state analogue and a potent, specific influenza viral neuraminidase inhibitor with an IC50 of median 0.09 nM.
G4061	Percp CD117/c-Kit Antibody [2B8]	KIT (c-KIT), also known as CD117, is a proto-oncogene and a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). KIT was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT together with its ligand regulates growth and activation of a variety of hemopoietic and non-hemopoietic cells. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Recently, deregulation of the KIT receptor TK by the prevalent activation loop mutation D816V has served as a focal point in therapeutic strategies aimed at curbing neoplastic mast cell growth. c-Kit is expressed in hematopoietic stem cells, germ cell
G0101	Percp CD11c Antibody [N418]	CD11, along with CD18, form a heterodimer adhesion molecule. In particular, CD11 is composed of CD11a, CD11b and CD11c. CD11a is a leukocyte marker that is expressed in B and T lymphocytes, macrophages, monocytes, neutrophils, basophils and eosinophils. CD11b is primarily expressed by monocytes, macrophages, natural killer cells, some B and T-cells, and granulocytes. CD11c is expressed in monocytes, macrophages, natural killer cells, some granulocytes and less so in a subset of lymphocytes.
H0176	Percp CD27 Antibody [O323]	CD27 (TNFRSF7) is a cell surface homodimer of ≥55 kDa subunits that provides co-stimulatory signaling in support of T cell (TCR) and B cell (BCR) receptors. Compared to CD28, whose TCR co-stimulatory signal can trigger cell proliferation, CD27 signaling promotes cell survival and differentiation to effector/memory stages. CD27 may be shed following interaction with its ligand CD70, which is typically expressed on activated dendritic cells, T cells, and B cells. In B cells, CD27 is a phenotypic marker for memory B cells and has also been included among markers for identifying B regulatory cells (Bregs), which regulate CD4+ T cell proliferation and Foxp3/CTLA-4 expression in Treg cells.
G0086	PerCP CD44 Antibody [IM7]
G0026	Percp CD45 Antibody [30-F11]	CD45, also known as Leukocyte Common Antigen (LCA). CD45 is expressed by all hematopoietic cells excluding mature erythrocytes and platelets. The cytoplasmic portion of CD45 has tyrosine phosphatase enzymatic activity and plays an important role in activation of lymphocytes.
G0356	Percp CD45.1 Antibody [A20]	CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides t
G0311	PerCP CD45.2 Antibody [104]
G0116	Percp CD45R/B220 Antibody [RA3-6B2]	CD45R (PTPRC) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. CD45 contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. CD45 is specifically expressed in hematopoietic cells and has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists in multiple isoforms as a result of alternative splicing, and these isoforms di
G3491	Percp CD5 Antibody [53-7.3]	CD5 is a 67 kDa human T-lymphocyte single-chain transmembrane glycoprotein. CD5 is present on all mature T-lymphocytes, on most of thymocytes and on many T-cell leukemias and lymphomas. CD5 also reacts with a subpopulation of activated B-cells and may act as a receptor in regulating T-cell proliferation. CD5 is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. CD5 is expressed by many T cell leukemia, lymphomas, and activated T cells. Diseases associated with CD5 dysfunction include thymus cancer and Richter's Syndrome.
G0251	Percp CD62L/L-Selectin Antibody [MEL-14]	The human CD62L is a 74-95 kDa glycoprotein member of the selectin family of adhesion receptors. L-Selectin is comprised of an aminoterminal C-type lectin binding domain, an epidermal growth factor-like domain, two short consensus repeat (SCR) sequences homologous to those found in complement binding proteins, a short spacer region, a transmembrane region and a short cytoplasmic region. Human CD62L (L-Selectin) is constitutively expressed on all classes of leukocytes including lymphocytes (except a substantial population of memory T cells), monocytes and polymorphonuclear cells.
G0011	Percp CD8a Antibody [53-6.7]	CD8 (Cluster of differentiation 8), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, plays an integral role in signal transduction, and T cell differentiation and activation. CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8alpha and CD8beta, where it functions as a co-receptor, along with T cell receptor (TCR), for major histocompatibilty complex class I (MHC-I) molecules; whereas its counterpart, CD4, acts as a co-receptor for MHC-II molecules. CD8 exists on the cell surface, where the CD8alpha chain is essential for binding to MHC-I. CD8 is also expressed on a subset of T cells, NK cells, monocytes and dendritic cells as disulfide-linked homodimers of CD8alpha. Ligation of MH
G3446	Percp CD90.2/Thy-1.2 Antibody [53-2.1]	CD90.2 (Thy 1) is an 18 kDa glycoprotein anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage and belongs to the immunoglobulin superfamily. It is expressed on murine T cells, thymocytes, neural cells, Kupffer cells, and fibroblasts. CD90.2 plays a role in cell-cell or cell-ligand interactions, potentially contributing to processes such as synaptogenesis and other brain-related events. It is expressed by hematopoietic cells and neurons, highly present in connective tissue, various fibroblast and stromal cell lines, as well as tumor endothelial cell lines. In mice, CD90.2 is expressed on all thymocytes and peripheral T lymphocytes.
G0071	PerCP F4/80 Antibody [BM8]
H0776	Percp FCER1A Antibody [AER-37 (CRA1)]	Fc epsilon RI alpha, also known as FcεRIα, is a subunit of the high-affinity receptor for IgE, primarily expressed on mast cells and basophils. Its expression is upregulated by the presence of IgE. FcεRIα forms a tetrameric complex with one beta and two gamma subunits, which are essential for signal transduction. The beta and gamma subunits contain immunoreceptor tyrosine-based activation motifs (ITAMs). The FcεRI complex plays a crucial role in triggering IgE-mediated allergic reactions.When allergen-bound IgE molecules bring together two or more high-affinity IgE receptors, it leads to the release of mediators such as histamine, which are responsible for allergy symptoms.This process couples allergens and mast cells to initiate inflamma
H0401	Percp Granzyme B Antibody [GB11]	Granzyme B is a member of the granzyme serine protease family, and is found in the granules of cytotoxic T cells and NK cells. Granzyme B has been described as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation, and CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells. Granzyme B is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. The receptor involved in this process has been identified as mannose 6-phosphate receptor which functions as a death receptor for Granzyme B during cytotoxic T cell-induced ap
H0461	Percp Human CD107a Antibody [H4A3]	CD107a, also known as Lysosomal-associated membrane protein 1 (LAMP-1), is a ~110 kDa type I transmembrane protein that is heavily glycosylated and widely expressed by cells primarily on the luminal surface of their lysosomes. It is also expressed on the surface of activated platelets, activated lymphocytes, cytotoxic T cells and NK cells, and some tumor cell lines, including U937 and KG1a. LAMP-1 can serve as a ligand for E-selectin-mediated cell adhesion. LAMP-1 and LAMP-2 (CD107b) are carriers for poly-N-acetyllactosamines and are able to display sialyl Le[x] termini.
H0191	Percp Human CD14 Antibody [M5E2]	CD14 is a 53–55 kDa glycosylphosphatidylinositol (GPI)-anchored single-chain glycoprotein expressed at high levels on monocytes, macrophages, and neutrophils. CD14 is a multifunctional receptor and is constitutively expressed on the surface of mature monocytes and macrophages. It serves as a high-affinity receptor for lipopolysaccharide (LPS) and binds LPS in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute-phase serum protein. CD14 also exists in a soluble form (sCD14) and is released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. The soluble sCD14 is important for neutralizing allochthonous lipopolysaccharides by reconstituted lipoprotein particles and can discriminate structural dif
H1136	Percp Human CD16 Antibody [3G8]	CD16a is a ~50–65 kDa type I transmembrane glycoprotein encoded by FCGR3A (Fc fragment of IgG receptor IIIa), which belongs to the immunoglobulin superfamily. CD16a is also known as Fc-gamma RIII-alpha (FcγRIIIA or FcRIIIa) and is expressed on natural killer (NK) cells, activated monocytes, macrophages, γδ T cells, immature thymocytes, and mast cells. CD16a binds immune-complexed or aggregated IgG and associates with CD247/TCRζ in NK cells and FcεRIγ chains in phagocytes and mast cells to transduce intracellular signals. CD16a functions in antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses including phagocytosis, cytokine production, or mediator release. CD16b is a ~48 kDa glycophosphatidylinositol (GPI)-
H3506	Percp Human CD163 Antibody [GHI/61]	CD163 is also known as Scavenger receptor cysteine-rich type 1 protein M130 (M130), Hemoglobin scavenger receptor and Macrophage-associated antigen. CD163 is a 110-130 kDa transmembrane glycoprotein. CD163 is a monocyte/macrophage-restricted antigen expressed on the majority of tissue macrophages and peripheral blood monocytes. CD163 belongs to the scavenger receptor superfamily. Its expression on monocytes is upregulated upon cellular activation. CD163 expression reportedly changes on monocytes and macrophages as these cells differentiate. This finding suggests a role for this molecule in the differentiation and/or regulation of monocyte and macrophage function. CD163 may play a role in the clearance and endocytosis of hemoglobin and hapto
H0011	Percp Human CD19 Antibody [HIB19]	CD19 is a 95 kDa type I transmembrane glycoprotein expressed during all stages of B-cell maturation and differentiation, except on plasma cells. It is also present on follicular dendritic cells but not found on T cells or normal granulocytes. CD19 functions as a signal transduction molecule that regulates B cell development, activation, proliferation, and differentiation. It associates with complement receptor 2 (CD21), TAPA-1 (CD81), Leu 13, and/or MHC class II to form a signal transduction complex on the surface of B cells.
H1166	Percp Human CD20 Antibody [2H7]	CD20 is a 33-37 kD, four transmembrane spanning protein, also known as B1 and Bp35. CD20 is expressed on pre-B-cells, resting and activated B cells (not plasma cells), some follicular dendritic cells, and at low levels on a T cell subset. CD20 is heavily phosphorylated on activated B cells and malignant B cells. Homo-oligomeric complexes of CD20 are thought to form Ca2+ conductive ion channels in the plasma membrane of B cells. The CD20 molecule is involved in B-cell activation and is associated with various Src family kinases (Lyn, Lck, Fyn). It exists in a complex with MHC class I and II, CD53, CD81, and CD82.
H4256	Percp Human CD25 Antibody [M-A251]	The CD25 antigen is also known as the human low-affinity interleukin-2 receptor α chain (IL-2Rα) and the Tac antigen. The CD25antigen is present on a subset of peripheral blood lymphocytes. Antigen density increases on phytohemagglutinin (PHA)-, concanavalin A (Con A)-, and CD3-activated T lymphocytes; T lymphocytes from mixed lymphocyte cultures; and HTLV-infected T-lymphocyte leukemia lines, for example, HUT-102. Recombinant IL-2 blocks the binding of CD25 to PHA-activated T lymphocytes. CD4+/CD25+ regulatory T cells might directly regulate the function of responsive T cells. The CD25antibody is composed of mouse IgG1 heavy chains and kappa light chains
H0446	Percp Human CD279/PD-1 Antibody [EH12.2H7]	Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC) are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.
H4106	Percp Human CD28 Antibody [CD28.2]	CD28 is a 44 kDa homodimeric transmembrane glycoprotein expressed on most mature T cells, thymocytes, and plasma cells. It acts as a costimulatory receptor, binding to CD80 and CD86 ligands, and plays a crucial role in T cell-B cell interactions. CD28 is believed to initiate and regulate a distinct signal transduction pathway that is separate from those stimulated by the TCR complex. The binding of CD28 to its ligands can also influence immune responses, including the production of IL-2 and changes in intracellular calcium concentrations.
H0926	Percp Human CD33 Antibody [WM53]	CD33, also known as Sialic acid-binding Ig-like lectin 3 (Siglec-3), gp67, or p67, is a 67 kDa type I transmembrane glycoprotein expressed on monocytes, activated T cells, myeloid progenitors, and mast cells. CD33 is absent on normal platelets, lymphocytes, erythrocytes, and hematopoietic stem cells. This glycoprotein can reportedly function as a sialic acid-dependent cell adhesion molecule. This function can be modulated by endogenous sialoglycoconjugates when CD33 is expressed on the membrane.
H0056	Percp Human CD4 Antibody [L200]	CD4 is a 56 kDa transmembrane glycoprotein expressed on the T-helper/inducer subset of peripheral blood lymphocytes in humans. It is primarily found on CD3-positive, CD8-negative T cells and does not react with B- or NK-cell markers. In baboons, CD4 is expressed on lymphocytes and weakly on monocytes. The distribution of CD4 on lymphocytes is similar between humans and these non-human primates.
H0041	Percp Human CD4 Antibody [RPA-T4]	CD4 is a 56 kDa transmembrane glycoprotein expressed on the T-helper/inducer subset of normal human peripheral blood lymphocytes. The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex
H4046	Percp Human CD42b Antibody [HIP1]	CD42b is also known as the Platelet glycoprotein Ib alpha chain that is encoded by the GP1BA gene. CD42b is disulfide bonded to CD42c to form a 170 kDa heterodimer, GPIb. GPIb forms a noncovalent complex with CD42a and CD42d (CD42 complex) that is expressed on platelets and megakaryocytes. The CD42 complex serves as the von Willebrand Factor (vWF) surface receptor involved in the adhesion of platelets to the subendothelium of damaged vascular walls. This antibody inhibits the ristocetin-dependent binding of vWF to platelets and partially inhibits collagen-induced aggregation.
H0116	PerCP Human CD45 Antibody [5B1]
H0101	Percp Human CD45 Antibody [HI30]	CD45 is encoded by the PTPRC (Protein tyrosine phosphatase receptor type C) gene. CD45, also known as the leukocyte common antigen (LCA), is a member of the protein tyrosine phosphatase (PTP) family. It is present on all human leukocytes including lymphocytes, monocytes, granulocytes, eosinophils, and thymocytes. CD45 is absent from circulating erythrocytes, platelets, or mature erythroid cells of bone marrow and non-hemopoietic tissues.
H0746	Percp Human CD45RA Antibody [HI100]	CD45RA, a 220 kDa isoform of the human leukocyte common antigen, is expressed on approximately 40–50% of peripheral CD4+ T cells, 50% of peripheral CD8+ T cells, and on a portion of B cells and monocytes. The CD45RA antigen is expressed by naïve and activated T cells. CD45RA-specific antibodies are useful for the study of the suppressor/inducer subpopulation of CD4+ lymphocytes.
H4016	Percp Human CD45RO Antibody [UCHL1]	CD45RO is a 180 kDa isoform of the CD45 molecule, also known as the Leukocyte Common Antigen. It is a type I transmembrane glycoprotein with cytoplasmic protein tyrosine phosphatase activity involved in signal transduction. Unlike other CD45 isoforms, CD45RO lacks the amino acid sequences encoded by the variable exons A, B, and C. It is expressed on most thymocytes, activated T cells, memory T cells, granulocytes, and monocytes, and on a subset of resting T cells. CD45RO and CD45RA mark largely distinct populations within resting peripheral T cells, demonstrating functional and phenotypic heterogeneity within CD4 and CD8 T cell subsets. CD45RO also interacts with CD22.
H3986	PerCP Human CD5 Antibody [UCHT2]
H3971	Percp Human CD61 Antibody [VI-PL2]	CD61 is a 105 kDa transmembrane glycoprotein that is also known as integrin β3 and platelet glycoprotein IIIa (GPIIIa or GP3A). It is expressed on platelets, megakaryocytes, osteoclasts and endothelia. Integrin β3 associates with gpIIa (CD41) to form the CD41/CD61 complex which mediates platelet adhesion and aggregation. CD61 also associates with CD51 to form the CD51/CD61 complex (vitronectin receptor). CD61 appears to bind to fibrinogen, fibronectin, vWF, vitronectin, and thrombospondin to mediate cell adhesion.
H0521	Percp Human CD68 Antibody [Y1/82A]	CD68, also known as Scavenger receptor class D member 1 (SCARD1), Macrosialin, or GP110, is a 110 kDa type I transmembrane glycoprotein primarily localized in cytoplasmic granules of monocytes, macrophages, dendritic cells, granulocytes, myeloid progenitor cells, and reportedly, a subset of CD34-positive hematopoietic bone marrow progenitor cells. CD68 belongs to the sialomucin family and functions as a scavenger receptor, capable of binding and internalizing oxidized low-density lipoproteins (LDL). Antibodies targeting CD68 are commonly used in studies of myeloid cell development and function.
H0371	Percp Human CD73 Antibody [AD2]	CD73, also known as ecto-5'-nucleotidase, is a 70 kDa, glycosyl phosphatidylinositol (GPI)-anchored glycoprotein. CD73 is expressed on subsets of T and B lymphocytes, follicular dendritic cells, epithelial cells, endothelial cells and mesenchymal stem cells. Its expression on lymphocytes increases during T and B cell development. CD73 has enzymatic activity and catalyzes the dephosphorylation of adenosine monophosphate (AMP), converting it to adenosine. It has been suggested that CD73 can mediate costimulatory signals in T cell activation and adhesion of lymphocytes to endothelium.
H0551	Percp Human CD8 Antibody [SK1]	CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.
H3881	PerCP Human CD82 Antibody [ASL-24]
H3701	Percp Human IgD Antibody [IA6-2]	IgD is a member of the immunoglobulin superfamily that exists in type 1-membrane (mIgD) and soluble glycoprotein forms. mIgD is expressed on mature naïve B cells (along with membrane IgM) and serves as a B-cell receptor for antigen (BCR). In response to antigen binding, the mIgD BCR, in association with other signaling molecules including CD79a and CD79b, can transduce activating or tolerizing signals intracellularly into B lymphocytes.
H1916	PerCP Human LAP/TGF-β1 Antibody [27232]
G3416	PerCP Human/Mouse TREM2 Antibody [237920]
H0131	Percp IFN-gamma Antibody [4S.B3]
G0371	Percp Ly-6A/E/Sca-1 Antibody [D7]	Stem Cell Antigen-1 (Sca-1) is a member of the lymphocyte antigen 6 (Ly-6) family. It is expressed on multipotent hematopoietic stem cells (HSC) and is used as a marker of HSC in mice. Sca-1 is used in combination with lineage depletion antibodies to identify murine HSC. Sca-1 can be found in fetal liver, adult bone marrow, and adult peripheral blood and spleen. Sca-1 may be involved in the regulation of B and T cell activation.
G4166	Percp Mouse CD3epsilon Antibody [145-2C11]	CD3epsilon is a 20 kDa transmembrane cell-surface protein that belongs to the immunoglobulin superfamily. It is one of five polypeptide chains that combine to form the T cell receptor (TCR) complex. CD3ε is expressed on T lymphocytes, NK-T cells, and to varying degrees on developing thymocytes. CD3 plays critical roles in TCR signaling, T lymphocyte activation, and antigen recognition.
G4151	Percp Mouse CD4 Antibody [GK1.5]	The CD4 antigen is a 55 kDa cell surface type I membrane glycoprotein belonging to the immunoglobulin superfamily. CD4 acts as a co-receptor which, in cooperation with the T cell receptor (TCR), interacts with class II MHC molecules displayed by antigen-presenting cells (APC). CD4 is expressed by the majority of thymocytes, most helper T cells, a subset of NK-T cells, and weakly by dendritic cells and macrophages. CD4 plays an important role in the development of T cells and is required for mature T cells to function optimally.
G1046	PerCP Mouse CD43 Activation-Associated Glycoform Antibody [1B11]
G4421	Percp Mouse CD86 Antibody [GL1]	CD86, along with CD80, is a member of the B7 family of costimulatory molecules and plays a crucial role in T cell activation and immune response regulation. CD86 is expressed at low levels on B cells, macrophages, and dendritic cells, and its expression is upregulated on B cells through various stimuli, including the BCR complex, CD40, and certain cytokine receptors. As a type I membrane protein and member of the immunoglobulin superfamily, CD86 serves as a ligand for the T cell surface proteins CD28 and CTLA-4 (CD152). The interaction between CD86 and CD28 provides a costimulatory signal essential for T cell activation during antigen presentation, while binding with CTLA-4 negatively regulates T cell activation, diminishing the immune resp
G4196	Percp Mouse IgG1 isotype control Antibody [MOPC-21]	Mouse IgG1 isotype control is a mouse myeloma protein. It was selected as an isotype control following screening for low background on a variety of mouse and human tissues.
G4436	Percp Mouse Ly6G Antibody [1A8]	Lymphocyte antigen 6 complex, locus G (Ly-6G), is a 21–25 kDa GPI-anchored protein expressed primarily on peripheral granulocytes and highly specific for neutrophils. Ly-6G serves as a robust marker for neutrophil identification and depletion in mice. Ly-6G modulates neutrophil migration and recruitment to sites of inflammation via interaction with β2 integrins. Its downregulation is associated with age-related functional decline in neutrophils.
G4256	Percp Mouse NK1.1 Antibody [PK136]	NK1.1, also known as CD161b/CD161c, KLRB1, NKR-P1A, and Ly-55, is a type II integral membrane glycoprotein with a C-type lectin domain and is encoded by the Klrb1c/NKR-P1C gene. NK1.1 plays roles in NK cell activation and differentiation, IFN-γ production, cytotoxic granule release, and is thought to be involved in the generation of Th2 cells. NK1.1 is predominantly expressed as a disulfide-linked homodimer on NK cells; however, it is also expressed on NK-T cells, a rare population of T lymphocytes. NK1.1 is only expressed by C57BL/6, FVB/N, and NZB strains of mice and not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129 strains.
G4361	Percp Mouse Ter-119 Antibody [TER-119]	TER-119 is a lineage marker for erythroid cells from early proerythroblast to mature erythrocyte stages in adult blood, spleen, and bone marrow. It is also present in yolk sac, and fetal and newborn liver. The TER-119 antigen is not expressed by cells of earlier erythroid development at BFU-e (blast-forming unit erythroid) stage or CFU-e (colony-forming unit erythroid) stage.
H2990	PerCP-Cy5.5 BCRP1 Antibody [5D3]
G3455	PerCP-Cy5.5 CD105/Endoglin Antibody [MJ7/18]	CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up-regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation-associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.
G4055	PerCP-Cy5.5 CD117/c-Kit Antibody [2B8]	KIT (c-KIT), also known as CD117, is a proto-oncogene and a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). KIT was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT together with its ligand regulates growth and activation of a variety of hemopoietic and non-hemopoietic cells. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Recently, deregulation of the KIT receptor TK by the prevalent activation loop mutation D816V has served as a focal point in therapeutic strategies aimed at curbing neoplastic mast cell growth. c-Kit is expressed in hematopoietic stem cells, germ cell
G2075	PerCP-Cy5.5 CD11b+CD11c Antibody [OX42]	CD11b (Integrin αM) and CD11c (Integrin αX) are α-chain integrins that belong to the β2 integrin family. They are primarily expressed on myeloid cells, including monocytes, macrophages, dendritic cells, and neutrophils. These integrins play key roles in cell adhesion, migration, phagocytosis, and immune regulation through interactions with ligands such as iC3b, ICAM-1, and fibrinogen. CD11b is highly expressed on monocytes and neutrophils, whereas CD11c is widely used as a marker for dendritic cells.
G0095	PerCP-Cy5.5 CD11c Antibody [N418]
G2975	PerCP-Cy5.5 CD122/IL-2Rβ Antibody [TM-β1]
G0455	PerCP-Cy5.5 CD127 Antibody [A7R34]	CD127, also known as the Interleukin-7 receptor alpha chain (IL-7Ralpha), is a type I glycoprotein with a molecular weight of 75-80 kDa. It forms a multi-functional receptor complex with CD132, the common gamma chain, to create the IL-7 receptor (IL-7R), which is crucial for lymphopoiesis. The active IL-7 receptor is an alpha/gamma chain heterodimer, where the gamma chain also associates with the interleukin-2 receptor and primarily activates signal transduction, while the alpha chain determines specific signaling events through its association with cytoplasmic signaling molecules. CD127 is expressed by immature B cells through the early pre-B stage, thymocytes during various stages of development, and most mature T cells, with transient do
H0335	PerCP-Cy5.5 CD161 Antibody [HP-3G10]	CD161, also known as NKR-P1A, is a type II transmembrane lectin-like receptor and member of the killer cell lectin-like receptor (KLR) family. CD161 exists as a homodimer and is prominently expressed on natural killer (NK) and NKT cells, where it is proposed to regulate the function of both cell types. CD161 is also found on T cell subsets, including T regulatory cells (Tregs), memory/effector CD4+ T cells, and CD8+ T cells. Th17 cells have been demonstrated to co-express CD161, as surface IL-17A+ cells are contained within the CD161+ fraction of CD4 T cells, so that CD161 (in combination with CCR6) is often used as a marker for enrichment of Th17 cells.
G1715	PerCP-Cy5.5 CD1d Antibody [1B1]
G4130	PerCP-Cy5.5 CD23 Antibody [B3B4]	CD23 is a 45 kDa glycoprotein that serves as a low-affinity receptor for IgE, playing a crucial role in regulating IgE responses and B cell activation. It is expressed on mature B cells, mantle zone B cells, follicular dendritic cells, and at lower levels on T cells, NK cells, Langerhans cells, and platelets. CD23 expression is upregulated upon B cell activation, and its soluble forms are biologically active, acting as potent mitogenic factors. CD23 is strongly expressed on Epstein-Barr virus (EBV)-transformed B lymphoblasts and is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells. It is also detected in neoplastic cells from cases of B cell chronic lymphocytic leukemia and some centroblastic/centrocytic lym
G0275	PerCP-Cy5.5 CD24 Antibody [M1/69]
H0170	PerCP-Cy5.5 CD27 Antibody [O323]	CD27 (TNFRSF7) is a cell surface homodimer of ≥55 kDa subunits that provides co-stimulatory signaling in support of T cell (TCR) and B cell (BCR) receptors. Compared to CD28, whose TCR co-stimulatory signal can trigger cell proliferation, CD27 signaling promotes cell survival and differentiation to effector/memory stages. CD27 may be shed following interaction with its ligand CD70, which is typically expressed on activated dendritic cells, T cells, and B cells. In B cells, CD27 is a phenotypic marker for memory B cells and has also been included among markers for identifying B regulatory cells (Bregs), which regulate CD4+ T cell proliferation and Foxp3/CTLA-4 expression in Treg cells.
H1340	PerCP-Cy5.5 CD273 Antibody [MIH18]
G1100	PerCP-Cy5.5 CD278 Antibody [C398.4A]
G0560	PerCP-Cy5.5 CD309/FLK1 Antibody [Avas12a1]
G0200	PerCP-Cy5.5 CD31/PECAM-1 Antibody [390]	CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulatio
H3605	PerCP-Cy5.5 CD324/E-Cadherin Antibody [DECMA-1]
G4100	PerCP-Cy5.5 CD326/EpCAM Antibody [G8.8]	Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA), also known as CD326, is a transmembrane glycoprotein expressed in the epithelium with a molecular weight of approximately 40 kDa, which functions as an epithelial cell adhesion molecule. Ep-CAM functions as a homotypic calcium-independent cell adhesion molecule, and has a direct impact on cell cycle, proliferation and metabolism of epithelial cells and fibroblasts due to its ability to rapidly induce the proto-oncogene c-myc and the cell cycle regulating genes cyclin A and E. Ep-CAM mediates Ca2+-independent homotypic interactions. Formation of Ep-CAM-mediated adhesions have a negative regulatory effect on adhesions mediated by classic cadherins, which may have strong
G2900	PerCP-Cy5.5 CD42d Antibody [1C2]
G0080	PerCP-Cy5.5 CD44 Antibody [IM7]	CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential. CD44 is expressed by hematopoietic, non-hematopoietic cells, epithelial tissu
G0020	PerCP-Cy5.5 CD45 Antibody [30-F11]	CD45, also known as Leukocyte Common Antigen (LCA). CD45 is expressed by all hematopoietic cells excluding mature erythrocytes and platelets. The cytoplasmic portion of CD45 has tyrosine phosphatase enzymatic activity and plays an important role in activation of lymphocytes.
G0350	PerCP-Cy5.5 CD45.1 Antibody [A20]	CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides t
G0110	PerCP-Cy5.5 CD45R/B220 Antibody [RA3-6B2]	CD45R (PTPRC) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. CD45 contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. CD45 is specifically expressed in hematopoietic cells and has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists in multiple isoforms as a result of alternative splicing, and these isoforms di
H1430	PerCP-Cy5.5 CD47 Antibody [B6H12]
G3485	PerCP-Cy5.5 CD5 Antibody [53-7.3]	CD5 is a 67 kDa human T-lymphocyte single-chain transmembrane glycoprotein. CD5 is present on all mature T-lymphocytes, on most of thymocytes and on many T-cell leukemias and lymphomas. CD5 also reacts with a subpopulation of activated B-cells and may act as a receptor in regulating T-cell proliferation. CD5 is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. CD5 is expressed by many T cell leukemia, lymphomas, and activated T cells. Diseases associated with CD5 dysfunction include thymus cancer and Richter's Syndrome.
G0245	PerCP-Cy5.5 CD62L/L-Selectin Antibody [MEL-14]	The human CD62L is a 74-95 kDa glycoprotein member of the selectin family of adhesion receptors. L-Selectin is comprised of an aminoterminal C-type lectin binding domain, an epidermal growth factor-like domain, two short consensus repeat (SCR) sequences homologous to those found in complement binding proteins, a short spacer region, a transmembrane region and a short cytoplasmic region. Human CD62L (L-Selectin) is constitutively expressed on all classes of leukocytes including lymphocytes (except a substantial population of memory T cells), monocytes and polymorphonuclear cells.
G0500	PerCP-Cy5.5 CD68 Antibody [FA-11]	CD68 is considered a pan-macrophage marker, predominantly expressed on the intracellular lysosomes of tissue macrophages/monocytes, including Kupffer cells, microglia, histiocytes and osteoclasts, and is expressed to a lesser extent by dendritic cells and peripheral blood granulocytes. CD68 is expressed by many tumor types including some B cell lymphomas, blastic NK lymphomas, melanomas, granulocytic (myeloid) sarcomas, hairy cell leukemias, and renal, urinary and pancreatic tumors, and can be used to demonstrate the presence/localization of macrophages.
G0215	PerCP-Cy5.5 CD80/B7-1 Antibody [16-10A1]	CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28, and of an inhibitory receptor CTLA-4 (CD152). Both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, and both molecules can also substitute for each other in this process. CD80 is rapidly induced on the surface of in vitro activated B cells, with Epstein Barr Virus (EBV) transformed B cell lines, with Burkitts lymphoma cell lines, with freshly isolated follicular B lymphoma cells, T cells, and monocytes. The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 and CTLA4 ligands of T cells. Diseases associated with CD80 dysfunct
H3440	PerCP-Cy5.5 CD85k/ILT3 Antibody [ZM4.1]
H1745	PerCP-Cy5.5 CD88 Antibody [S5/1]	Mouse anti Human CD88 antibody, recognizes the C5a receptor (C5aR) CD88, which is predominantly expressed on cells of the myeloid lineage. It was raised against a synthetic peptide comprising the N-terminal extracellular domain of the C5aR (met1-Asn31) and has recently been shown to recognise the heptameric peptide (D15DKDTLD21). It has been shown to inhibit the binding of C5a to its receptor.
G0005	PerCP-Cy5.5 CD8a Antibody [53-6.7]
G0740	PerCP-Cy5.5 CD90.1/Thy-1.1 Antibody [HIS51]	CD90 (Thy 1) antigen is a GPI linked glycoprotein member of the Immunoglobulin super family. It is expressed in murine T cells, thymocytes, neural cells, Kupffer's cells and fibroblasts. Thy 1 may play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
G2630	PerCP-Cy5.5 CD93 Antibody [AA4.1]	CD93 (also known as AA4.1, C1qRp) is a cell-surface glycoprotein and type I membrane protein originally identified as a myeloid cell marker. Although previously considered a C1q receptor, CD93 is now recognized for its roles in intercellular adhesion and the clearance of apoptotic cells. Its intracellular tail interacts with moesin, linking CD93 to the cytoskeleton and cytoskeletal remodeling.
G4925	PerCP-Cy5.5 CXCR4 Antibody [UMB2]
G0065	PerCP-Cy5.5 F4/80 Antibody [BM8]
H0770	PerCP-Cy5.5 FCER1A Antibody [AER-37 (CRA1)]
G0755	PerCP-Cy5.5 FCER1A Antibody [MAR-1]	Fc epsilon RI alpha, also known as FceR1 alpha, is a subunit of the high-affinity receptor for IgE, primarily expressed on mast cells and basophils. Its expression is upregulated by the presence of IgE. Fc epsilon RI alpha forms a tetrameric complex with one beta and two gamma subunits, which are essential for signal transduction. The beta and gamma subunits contain immunoreceptor tyrosine-based activation motifs (ITAMs). The Fc epsilon RI complex plays a crucial role in triggering IgE-mediated allergic reactions. When allergen-bound IgE molecules bring together two or more high-affinity IgE receptors, it leads to the release of mediators such as histamine, which are responsible for allergy symptoms. This process couples allergens and mast
H2765	PerCP-Cy5.5 Human B7-H4 Antibody [MIH43]
H1460	PerCP-Cy5.5 Human CD10 Antibody [HI10a]	CD10, also known as Neutral Endopeptidase (NEP), Enkephalinase, Atriopeptidase, and Neprilysin, is a 100 kDa type II transmembrane glycoprotein encoded by the MME (membrane metallo-endopeptidase) gene. CD10 has neutral endopeptidase activity and is also referred to as the Common Acute Lymphoblastic Leukemia Antigen (CALLA). It is expressed on a wide variety of normal and neoplastic cell types, including granulocytes, bone marrow stromal cells, a subset of B-cell progenitors, germinal center B cells, and fibroblasts. CD10 is a cell surface metalloendopeptidase that inactivates several signaling molecules, playing a significant regulatory role in the nervous, immune, and other systems.
H0455	PerCP-Cy5.5 Human CD107a Antibody [H4A3]	CD107a, also known as Lysosomal-associated membrane protein 1 (LAMP-1), is a ~110 kDa type I transmembrane protein that is heavily glycosylated and widely expressed by cells primarily on the luminal surface of their lysosomes. It is also expressed on the surface of activated platelets, activated lymphocytes, cytotoxic T cells and NK cells, and some tumor cell lines, including U937 and KG1a. LAMP-1 can serve as a ligand for E-selectin-mediated cell adhesion. LAMP-1 and LAMP-2 (CD107b) are carriers for poly-N-acetyllactosamines and are able to display sialyl Le[x] termini.
H0680	PerCP-Cy5.5 Human CD115/CSF-1R Antibody [9-4D2-1E4]
H0380	PerCP-Cy5.5 Human CD117 Antibody [104D2]	CD117 is a 145 kD protein tyrosine kinase also known as c-Kit. It is a receptor for stem cell factor or c-Kit ligand. CD117 is expressed on pluripotent hematopoietic progenitor cells (approximately 1-4% bone marrow cells), mast cells, and acute myeloid leukemia cells (AML). CD117 binding of c-Kit ligand induces phosphorylation of CD117 and stimulates proliferation and survival of primitive hematopoietic stem cells as well as erythroid-committed and granulo-monocytic committed cells.
H0080	PerCP-Cy5.5 Human CD11b Antibody [CBRM1/5]	CD11b, a 165-170 kDa type I transmembrane glycoprotein also known as αM integrin, Mac-1, CR3, and C3biR. CD11b non-covalently associates with integrin β2 (CD18) and is expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b/CD18 is critical for the transendothelial migration of monocytes and neutrophils as well as adhesion, phagocytosis, and neutrophil activation. CD11b/CD18 interacts with ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4, CD14, CD23, heparin, iC3b, fibrinogen and factor X.
H0065	PerCP-Cy5.5 Human CD11b Antibody [ICRF44]	CD11b is a 165-170 kD type I transmembrane glycoprotein also known as αM integrin, Mac-1, CR3, and C3biR. CD11b non-covalently associates with integrin β2 (CD18) and is expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b/CD18 is critical for the transendothelial migration of monocytes and neutrophils. It is also involved in granulocyte adhesion, phagocytosis, and neutrophil activation. CD11b/CD18 interacts with ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4, CD14, CD23, heparin, iC3b, fibrinogen, and factor X.
H0140	PerCP-Cy5.5 Human CD11c Antibody [3.9]	CD11c is a 145–150 kDa type I transmembrane glycoprotein also known as integrin αx and CR4. CD11c non-covalently associates with integrin β2 (CD18) and is expressed on monocytes/macrophages, dendritic cells, granulocytes, NK cells, and subsets of T and B cells. CD11c has been reported to play a role in adhesion and CTL killing through its interactions with fibrinogen, CD54, and iC3b.
H2570	PerCP-Cy5.5 Human CD126/IL-6Rα Antibody [UV4]
H0485	PerCP-Cy5.5 Human CD127 Antibody [HIL-7R-M21]	CD127 is a 60–90 kDa glycoprotein, also known as the IL-7 receptor alpha (IL-7Rα) subunit. The IL-7 receptor complex is a heterodimer composed of CD127 and the common gamma chain (γc, CD132), shared by other cytokine receptors (IL-2R, IL-4R, IL-9R, IL-15R, and IL-21R). CD127 is expressed on thymocytes, T- and B-cell progenitors, mature T cells, and some lymphoid and myeloid cells. In vitro experiments show the expression of CD127 is down-regulated following T cell activation. Studies indicate that the IL-7 receptor plays an important role in the proliferation and differentiation of mature T cells. Recently, it has been shown that low surface expression of CD127, in combination with intermediate to high surface expression of CD25, the α chai
H3800	PerCP-Cy5.5 Human CD137 Antibody [4B4-1]	CD137 is a 39 kD transmembrane protein also known as 4-1BB. It is expressed on activated T cells. CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily. CD137 appears to be important for T cell proliferation and survival, and induces monocyte activation through its interaction with 4-1BB ligand.
H0185	PerCP-Cy5.5 Human CD14 Antibody [M5E2]	CD14 is a 53–55 kDa glycosylphosphatidylinositol (GPI)-anchored single-chain glycoprotein expressed at high levels on monocytes, macrophages, and neutrophils. CD14 is a multifunctional receptor and is constitutively expressed on the surface of mature monocytes and macrophages. It serves as a high-affinity receptor for lipopolysaccharide (LPS) and binds LPS in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute-phase serum protein. CD14 also exists in a soluble form (sCD14) and is released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. The soluble sCD14 is important for neutralizing allochthonous lipopolysaccharides by reconstituted lipoprotein particles and can discriminate structural dif
H4430	PerCP-Cy5.5 Human CD140b Antibody [28D4]
H1970	PerCP-Cy5.5 Human CD141/Thrombomodulin Antibody [M80]
H1685	PerCP-Cy5.5 Human CD144/VE-cadherin Antibody [55-7H1]	Cadherin-5, a member of the cadherin family of calcium-dependent adhesion molecules, is also known as CD144 or VE-Cadherin. CD144 is expressed on endothelial cells in vivo and in vitro. It may play a role in the organization of lateral endothelial junctions and in the control of permeability properties of vascular endothelium.
H1040	PerCP-Cy5.5 Human CD146 Antibody [P1H12]	CD146, also known as MCAM, MUC18, or Mel-CAM, is a 118 kDa transmembrane glycoprotein and a member of the immunoglobulin superfamily. It is strongly expressed by blood vessel endothelium and smooth muscle. CD146 is also found on angioblasts, mesenchymal stem cells, melanoma cells, intermediate trophoblasts, and a subset of activated T cells. CD146 is widely used as a marker for endothelial cells and plays a key role in studies of angiogenesis, cancer progression, and vascular biology.
H1355	PerCP-Cy5.5 Human CD152/CTLA-4 Antibody [BNI3]	CD152, also known as CTLA-4 (Cytolytic T Lymphocyte-Associated Antigen 4), is a molecule transiently expressed on activated CD28+ T cells. It binds to CD80 and CD86 on antigen-presenting cells (APCs) with high avidity, delivering a negative regulatory signal to the T cell. It has also been shown that CTLA-4 is expressed on B cells when cultured with activated T cells, indicating a role in regulating the B-cell response. Additionally, CD152 is expressed on regulatory T (Treg) cells. The BNI3 monoclonal antibody specifically binds to human CTLA-4 and can be used to study its role in T-cell proliferation and regulation.
H1370	PerCP-Cy5.5 Human CD155/PVR Antibody [SKII.4]
H1130	PerCP-Cy5.5 Human CD16 Antibody [3G8]	CD16a is a ~50–65 kDa type I transmembrane glycoprotein encoded by FCGR3A (Fc fragment of IgG receptor IIIa), which belongs to the immunoglobulin superfamily. CD16a is also known as Fc-gamma RIII-alpha (FcγRIIIA or FcRIIIa) and is expressed on natural killer (NK) cells, activated monocytes, macrophages, γδ T cells, immature thymocytes, and mast cells. CD16a binds immune-complexed or aggregated IgG and associates with CD247/TCRζ in NK cells and FcεRIγ chains in phagocytes and mast cells to transduce intracellular signals. CD16a functions in antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses including phagocytosis, cytokine production, or mediator release. CD16b is a ~48 kDa glycophosphatidylinositol (GPI)-
H2135	PerCP-Cy5.5 Human CD160 Antibody [BY55]	CD160 is a 27 kD GPI-anchored glycoprotein also known as BY55, NK1, and NK28. A member the Ig superfamily, CD160 exists as a disulfide-bond multimer, expressed on the surface of a subpopulation of NK cells, γ/δ T cells, subset of CD8+ T cells, and intestinal intraepithelial lymphocytes (IEL). CD160 plays costimulatory roles through binding to classical and nonclassical MHC-I molecules.
H3500	PerCP-Cy5.5 Human CD163 Antibody [GHI/61]
H2825	PerCP-Cy5.5 Human CD166/ALCAM Antibody [3A6]	CD166, also known as Activated Leukocyte Cell Adhesion Molecule (ALCAM) and the CD6 ligand, is a 100–105 kDa transmembrane glycoprotein belonging to the immunoglobulin superfamily. It consists of an immunoglobulin-like extracellular domain, a transmembrane region, and a short cytoplasmic tail. CD166 is expressed on neurons, activated T cells, activated monocytes, epithelial cells, and fibroblasts. It plays a key role in mediating adhesion interactions, particularly between thymic epithelial cells and CD6+ cells during intrathymic T-cell development.
H0950	PerCP-Cy5.5 Human CD169 Antibody [7-239]
H2105	PerCP-Cy5.5 Human CD172a/b Antibody [SE5A5]
H1235	PerCP-Cy5.5 Human CD185 Antibody [RF8B2]
H0005	PerCP-Cy5.5 Human CD19 Antibody [HIB19]	CD19 is a 95 kDa type I transmembrane glycoprotein expressed during all stages of B-cell maturation and differentiation, except on plasma cells. It is also present on follicular dendritic cells but not found on T cells or normal granulocytes. CD19 functions as a signal transduction molecule that regulates B cell development, activation, proliferation, and differentiation. It associates with complement receptor 2 (CD21), TAPA-1 (CD81), Leu 13, and/or MHC class II to form a signal transduction complex on the surface of B cells.
H1535	PerCP-Cy5.5 Human CD194/CCR4 Antibody [L291H4]
H1580	PerCP-Cy5.5 Human CD1a Antibody [HI149]	CD1a is a type I transmembrane glycoprotein. The 49 kDa CD1a polypeptide is associated with β2-microglobulin. CD1a is expressed on cortical thymocytes, dendritic cells and Langerhans cells. CD1a has structural similarities to the MHC class I antigen, and plays a role in antigen presentation.
H1595	PerCP-Cy5.5 Human CD1c Antibody [L161]	CD1c, also known as R7 or M241, is a 43 kD member of the five CD1 antigens (CD1a-e) in humans. The CD1 molecules are type I glycoprotein with structural similarities to MHC class I and are non-covalently associated with β2-microglobulin, belonging to the Ig superfamily. CD1c is expressed on cortical thymocytes, Langerhans cells, dendritic cells, and a subset of B cells. It has been reported that CD1c is also expressed on mature T cells in a tightly regulated manner. CD1c is involved in antigen-presentation of glycolipids. It may also act in T cells as an immune regulatory molecule.
H1160	PerCP-Cy5.5 Human CD20 Antibody [2H7]	CD20 is a 33-37 kD, four transmembrane spanning protein, also known as B1 and Bp35. CD20 is expressed on pre-B-cells, resting and activated B cells (not plasma cells), some follicular dendritic cells, and at low levels on a T cell subset. CD20 is heavily phosphorylated on activated B cells and malignant B cells. Homo-oligomeric complexes of CD20 are thought to form Ca2+ conductive ion channels in the plasma membrane of B cells. The CD20 molecule is involved in B-cell activation and is associated with various Src family kinases (Lyn, Lck, Fyn). It exists in a complex with MHC class I and II, CD53, CD81, and CD82.
H0875	PerCP-Cy5.5 Human CD23 Antibody [M-L233]
H0320	PerCP-Cy5.5 Human CD24 Antibody [ML5]	CD24, also known as CD24A, signal transducer CD24, small cell lung carcinoma cluster 4 antigen, or BA-1, is a 35-70 kDa glycophosphatidylinositol (GPI)-linked glycoprotein. Its glycosylation pattern is highly variable and cell-type dependent. CD24 is expressed on neutrophils, eosinophils, dendritic cells, neural cells, epithelial cells, muscle cells, and many types of cancer cells. CD24 functions as an adhesion receptor. Several different ligands have been identified for CD24, including CD62P (P-selectin), which is expressed on activated platelets and activated endothelium. CD24 is variably expressed on all B lineage cells, except plasma cells, and can play a role in regulating the activation, proliferation, or differentiation of these cell
H1610	PerCP-Cy5.5 Human CD244/2B4 Antibody [C1.7]
H4250	PerCP-Cy5.5 Human CD25 Antibody [M-A251]	The CD25 antigen is also known as the human low-affinity interleukin-2 receptor α chain (IL-2Rα) and the Tac antigen. The CD25antigen is present on a subset of peripheral blood lymphocytes. Antigen density increases on phytohemagglutinin (PHA)-, concanavalin A (Con A)-, and CD3-activated T lymphocytes; T lymphocytes from mixed lymphocyte cultures; and HTLV-infected T-lymphocyte leukemia lines, for example, HUT-102. Recombinant IL-2 blocks the binding of CD25 to PHA-activated T lymphocytes. CD4+/CD25+ regulatory T cells might directly regulate the function of responsive T cells. The CD25antibody is composed of mouse IgG1 heavy chains and kappa light chains
H3365	PerCP-Cy5.5 Human CD26 Antibody [BA5b]
H1985	PerCP-Cy5.5 Human CD269/BCMA Antibody [19F2]
H0440	PerCP-Cy5.5 Human CD279/PD-1 Antibody [EH12.2H7]	Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC) are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.
H4100	PerCP-Cy5.5 Human CD28 Antibody [CD28.2]	CD28 is a 44 kDa homodimeric transmembrane glycoprotein expressed on most mature T cells, thymocytes, and plasma cells. It acts as a costimulatory receptor, binding to CD80 and CD86 ligands, and plays a crucial role in T cell-B cell interactions. CD28 is believed to initiate and regulate a distinct signal transduction pathway that is separate from those stimulated by the TCR complex. The binding of CD28 to its ligands can also influence immune responses, including the production of IL-2 and changes in intracellular calcium concentrations.
H1760	PerCP-Cy5.5 Human CD294/CRTH2 Antibody [BM16]
H4280	PerCP-Cy5.5 Human CD3 Antibody [OKT-3]	CD3ε is one of five polypeptide chains that combine to form the TCR complex. CD3ε is expressed on T lymphocytes, NK-T cels, and to varying degrees on developing thymocytes. CD3 plays roles in TCR signaling, T lymphocyte activation, and antigen recognition.
H4355	PerCP-Cy5.5 human CD3 Antibody [UCHT1]
H0230	PerCP-Cy5.5 Human CD31 Antibody [WM59]	CD31 (PECAM-1), also known as GPIIA' or EndoCAM, is a 130 kDa type I transmembrane glycoprotein belonging to the Ig gene superfamily. It is widely expressed on platelets, monocytes, granulocytes, NK cells, T cell subsets, and in high amounts on endothelial cells. CD31 functions as a vascular endothelial cell adhesion molecule, playing a critical role in the transendothelial migration of leukocytes during inflammatory responses. It is also involved in thrombosis, angiogenesis, and wound healing. The antibody against PECAM-1 binds to an epitope near extracellular domain 2 of CD31. Clone WM59 also cross-reacts with peripheral blood platelets and leukocytes of baboon, and both rhesus and cynomolgus macaque monkeys. The staining intensity of WM5
H1400	PerCP-Cy5.5 Human CD314/NKG2D Antibody [1D11]	CD314, also known as NKG2D or KLRK1, is a 42 kDa type II transmembrane glycoprotein and a member of the C-type lectin family. It is expressed on human NK cells, as well as on virtually all TCR γ/δ+ and CD8+ TCR α/β+ T cells. NKG2D functions as an activating receptor that binds strongly to several ligands, including MICA, MICB, and ULBP-1, -2, and -3, which are expressed by different target cell types. Unlike other natural cytotoxicity receptors (NCR), NKG2D is not restricted to NK cells. It plays a critical role in natural cytotoxicity, aiding normal NK cells in attacking a variety of tumor or normal target cells. NKG2D can complement the role of NCR in tumor cell lysis, and combined masking of both NCR and NKG2D can lead to a complete inhi
H3200	PerCP-Cy5.5 Human CD325/N-Cadherin Antibody [8C11]
H0920	PerCP-Cy5.5 Human CD33 Antibody [WM53]	CD33, also known as Sialic acid-binding Ig-like lectin 3 (Siglec-3), gp67, or p67, is a 67 kDa type I transmembrane glycoprotein expressed on monocytes, activated T cells, myeloid progenitors, and mast cells. CD33 is absent on normal platelets, lymphocytes, erythrocytes, and hematopoietic stem cells. This glycoprotein can reportedly function as a sialic acid-dependent cell adhesion molecule. This function can be modulated by endogenous sialoglycoconjugates when CD33 is expressed on the membrane.
H1775	PerCP-Cy5.5 Human CD337/NKp30 Antibody [P30-15]	NKp30 is a type I transmembrane protein, member of the natural cytotoxicity receptor family that contains one immunoglobulin-like domain. NKp30 has an apparent molecular weight of 30 kD and six isoforms are produced by alternative splicing. NKp30 is expressed on resting and activated NK cells. NKp30 enhances NK cell cytolysis of tumor cellts that are deficient in MHC class I molecules. NKp30 has been shown to associate with CD59 and TCRζ.
H3650	PerCP-Cy5.5 Human CD366 Antibody [F38-2E2]
H0860	PerCP-Cy5.5 Human CD38 Antibody [HIT2]	The CD38 antigen is also known as T10, ADP-ribosyl cyclase 1, and cyclic ADP ribose hydrolase 1. CD38 is a 45 kDa type II single-chain transmembrane glycoprotein present on thymocytes, activated T cells, and terminally differentiated B cells (plasma cells). It is also expressed by monocytes, macrophages, dendritic cells, NK cells, myeloid and erythroid precursors, and some epithelial cells. CD38 functions as an ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose, a Ca²⁺-mobilizing second messenger. This intracellular calcium plays an important role in cell signaling pathways leading to cellular growth, apoptosis, and differentiation. CD38 binds to CD31, contributing to lymphocyte adhesion to endothelial cells.
H3380	PerCP-Cy5.5 Human CD39 Antibody [A1]
H0050	PerCP-Cy5.5 Human CD4 Antibody [L200]	CD4 is a 56 kDa transmembrane glycoprotein expressed on the T-helper/inducer subset of peripheral blood lymphocytes in humans. It is primarily found on CD3-positive, CD8-negative T cells and does not react with B- or NK-cell markers. In baboons, CD4 is expressed on lymphocytes and weakly on monocytes. The distribution of CD4 on lymphocytes is similar between humans and these non-human primates.
H0035	PerCP-Cy5.5 Human CD4 Antibody [RPA-T4]	CD4 is a 56 kDa transmembrane glycoprotein expressed on the T-helper/inducer subset of normal human peripheral blood lymphocytes. The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex
H0560	PerCP-Cy5.5 Human CD40 Antibody [5C3]	CD40 is a 45–48 kDa type I transmembrane glycoprotein primarily expressed on B lymphocytes, though it is absent on terminally differentiated B cells. It is also found on endothelial cells, basal epithelial cells, certain epithelial cell carcinomas, follicular dendritic cells, macrophages, fibroblasts, keratinocytes, and CD34+ hematopoietic progenitor cells. CD40 plays a critical role in B-cell growth, proliferation, and differentiation, including immunoglobulin isotype switching. Engagement of CD40, particularly in the presence of IL-4 or costimulation with anti-µ or anti-CD20 antibodies, can promote B-cell proliferation.
H0890	PerCP-Cy5.5 Human CD41a Antibody [HIP8]	CD41a, also known as Integrin αIIb or Platelet GPIIb, forms a calcium-dependent complex with CD61 (β3 integrin or GPIIIa) that is normally expressed on platelets and megakaryocytes. The CD41/CD61 complex serves as a receptor for fibrinogen, fibronectin, and von Willebrand factor, mediating platelet adhesion and aggregation. Blocking CD41 can completely inhibit ADP-, epinephrine-, and collagen-induced platelet activation, and partially inhibit ristocetin- and thrombin-induced activation.
H0095	PerCP-Cy5.5 Human CD45 Antibody [HI30]	CD45 is encoded by the PTPRC (Protein tyrosine phosphatase receptor type C) gene. CD45, also known as the leukocyte common antigen (LCA), is a member of the protein tyrosine phosphatase (PTP) family. It is present on all human leukocytes including lymphocytes, monocytes, granulocytes, eosinophils, and thymocytes. CD45 is absent from circulating erythrocytes, platelets, or mature erythroid cells of bone marrow and non-hemopoietic tissues.
H0740	PerCP-Cy5.5 Human CD45RA Antibody [HI100]	CD45RA, a 220 kDa isoform of the human leukocyte common antigen, is expressed on approximately 40–50% of peripheral CD4+ T cells, 50% of peripheral CD8+ T cells, and on a portion of B cells and monocytes. The CD45RA antigen is expressed by naïve and activated T cells. CD45RA-specific antibodies are useful for the study of the suppressor/inducer subpopulation of CD4+ lymphocytes.
H4010	PerCP-Cy5.5 Human CD45RO Antibody [UCHL1]	CD45RO is a 180 kDa isoform of the CD45 molecule, also known as the Leukocyte Common Antigen. It is a type I transmembrane glycoprotein with cytoplasmic protein tyrosine phosphatase activity involved in signal transduction. Unlike other CD45 isoforms, CD45RO lacks the amino acid sequences encoded by the variable exons A, B, and C. It is expressed on most thymocytes, activated T cells, memory T cells, granulocytes, and monocytes, and on a subset of resting T cells. CD45RO and CD45RA mark largely distinct populations within resting peripheral T cells, demonstrating functional and phenotypic heterogeneity within CD4 and CD8 T cell subsets. CD45RO also interacts with CD22.
H1250	PerCP-Cy5.5 Human CD54 Antibody [HA58]	CD54, also known as Intercellular Adhesion Molecule 1 (ICAM-1), is an 85-110 kDa type I transmembrane glycoprotein that belongs to the immunoglobulin supergene family. A soluble form of CD54 can also be found in biological fluids. CD54 is expressed on endothelial cells, as well as on both resting (weak) and activated (moderate) lymphocytes and monocytes. It serves as a ligand for LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). The CD54 adhesion molecule plays a key role in inflammatory and immune responses, as well as in neoplasia.
H3965	PerCP-Cy5.5 Human CD61 Antibody [VI-PL2]	CD61 is a 105 kDa transmembrane glycoprotein that is also known as integrin β3 and platelet glycoprotein IIIa (GPIIIa or GP3A). It is expressed on platelets, megakaryocytes, osteoclasts and endothelia. Integrin β3 associates with gpIIa (CD41) to form the CD41/CD61 complex which mediates platelet adhesion and aggregation. CD61 also associates with CD51 to form the CD51/CD61 complex (vitronectin receptor). CD61 appears to bind to fibrinogen, fibronectin, vWF, vitronectin, and thrombospondin to mediate cell adhesion.
H0290	PerCP-Cy5.5 Human CD62L Antibody [DREG-56]
H1325	PerCP-Cy5.5 Human CD63 Antibody [H5C6]	CD63 is a 53 kDa, type III lysosomal glycoprotein that belongs to the tetraspan transmembrane 4 superfamily (TM4SF). It is expressed on activated platelets, monocytes, and macrophages, and is also known by several other names, including LIMP, gp55, melanoma-associated antigen ME491, Pltgp40, and LAMP-3. CD63 is widely expressed on the surface and in the cytoplasm of various hematopoietic cells (such as monocytes and macrophages) as well as non-hematopoietic cells (including endothelium, fibroblasts, osteoclasts, and smooth muscle cells). It plays a key role in mediating cellular adhesion and motility.
H0515	PerCP-Cy5.5 Human CD68 Antibody [Y1/82A]
H3995	PerCP-Cy5.5 Human CD7 Antibody [M-T701]
H1880	PerCP-Cy5.5 Human CD70 Antibody [113-16]
H0365	PerCP-Cy5.5 Human CD73 Antibody [AD2]	CD73, also known as ecto-5'-nucleotidase, is a 70 kDa, glycosyl phosphatidylinositol (GPI)-anchored glycoprotein. CD73 is expressed on subsets of T and B lymphocytes, follicular dendritic cells, epithelial cells, endothelial cells and mesenchymal stem cells. Its expression on lymphocytes increases during T and B cell development. CD73 has enzymatic activity and catalyzes the dephosphorylation of adenosine monophosphate (AMP), converting it to adenosine. It has been suggested that CD73 can mediate costimulatory signals in T cell activation and adhesion of lymphocytes to endothelium.
H2000	PerCP-Cy5.5 Human CD79b/Igβ Antibody [CB3-1]
H0545	PerCP-Cy5.5 Human CD8 Antibody [SK1]	CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.
H3875	PerCP-Cy5.5 Human CD82 Antibody [ASL-24]
H1475	PerCP-Cy5.5 Human CD83 Antibody [HB15e]	CD83 is a 45 kDa type I transmembrane glycoprotein that belongs to the immunoglobulin (Ig) superfamily. It is composed of a single V-type Ig extracellular domain and a C-terminal cytoplasmic tail. CD83 is primarily expressed on the surface of follicular dendritic cells, circulating dendritic cells, interdigitating dendritic cells in lymphoid tissues, in vitro-generated dendritic cells, and thymic dendritic cells. However, its expression is not limited to dendritic cells; it is also found on some germinal center B cells and certain lymphoblastoid cell lines. While the exact function of CD83 is not fully understood, it is believed to play a role in cell-cell interactions during antigen presentation.
H4025	PerCP-Cy5.5 Human CD9 Antibody [HI9a]
H0305	PerCP-Cy5.5 Human CD90 Antibody [P15F7]	CD90, also known as Thy-1, is a 25-35 kDa glycophosphatidylinositol-anchored membrane glycoprotein of the Ig superfamily. It is expressed on 1-4% of human fetal liver cells, cord blood cells, and bone marrow cells. CD90 is present on a subset of immature CD34+ cells and a distinct subset of mature CD34- cells that are CD3+CD4+. The CD90+CD34+ population is highly enriched for cells capable of long-term culture. The anti-CD90 antibody is useful for enriching high proliferative potential colony-forming cells (HIPP-CFC), which are primitive progenitor cells.
H1820	PerCP-Cy5.5 Human CD94 Antibody [HP-3D9]
H1700	PerCP-Cy5.5 Human Galectin-9 Antibody [9M1-3]
H2075	PerCP-Cy5.5 Human Granzyme A Antibody [CB9]
H1790	PerCP-Cy5.5 Human HLA-A2 Antibody [BB7.2]	HLA-A2 is a class I molecule of the major histocompatibility complex (MHC) and part of the highly polymorphic group of cell-surface proteins encoded by the MHC gene locus. It plays a crucial role in the immune response by binding and presenting small antigenic protein fragments to antigen-specific receptors on T cells (TCR). Class I MHC molecules, like HLA-A2, bind peptides derived from intracellular antigens, such as viral and some bacterial antigens, which are recognized by CD8+ T cells. The TCRs recognize these processed peptides bound to the MHC, as well as regions of the MHC molecule itself, while CD4 and CD8 accessory molecules enhance the interaction by binding non-polymorphic regions of the MHC.
H3680	PerCP-Cy5.5 Human Ig light chain lambda Antibody [MHL-38]
H3665	PerCP-Cy5.5 Human Ig light chain κ Antibody [MHK-49]
H3695	PerCP-Cy5.5 Human IgD Antibody [IA6-2]
H2270	PerCP-Cy5.5 Human IgG Fc Antibody [M1310G05]
H1010	PerCP-Cy5.5 Human IgM Antibody [MHM-88]
H1220	PerCP-Cy5.5 Human IL-2 Antibody [MQ1-17H12]
H0425	PerCP-Cy5.5 Human IL-4 Antibody [MP4-25D2]
H2630	PerCP-Cy5.5 Human NKB1 Antibody [DX9]
H4295	PerCP-Cy5.5 Human PD-L1 Antibody [29E.2A3]
H3170	PerCP-Cy5.5 Human ROR1 Antibody [2A2]
H4400	PerCP-Cy5.5 human SSEA-4 Antibody [MC813]	The antibody reacts with Stage-Specific Embryonic Antigen-4 (SSEA-4), a carbohydrate epitope on the major ganglioside, but not the neutral glycolipid, of human teratocarcinoma cells. As its name implies, the expression of SSEA-4 is stage-specific and can be used to characterize embryonic cells and monitor their differentiation. However, its expression pattern differs in the human and mouse. In the human, SSEA-4 is found on teratocarcinoma (embryonal carcinoma or EC), embryonic inner cell mass (ICM), embryonic stem (ES) cells, and the K562 erythromyeloid leukeumia cell line. As human stem cells undergo differentiation, SSEA-4 expression is lost. In the mouse, SSEA-4 is found on oocytes and early cleavage-stage embryos, and primitive ect
H0965	PerCP-Cy5.5 Human TCR gammadelta Antibody [B1]
H1850	PerCP-Cy5.5 Human TCR Vα7.2 Antibody [3C10]	The antibody recognizes the Vα7.2 T cell antigen receptor (TCR) α-chain segment which, joined with the Jα33 segment, constitutes an invariant TCR that is a characteristic of the mucosalassociated invariant T cells (MAIT cells). MAIT cells are restricted by a nonpolymorphic class Ib major histocompatibility complex (MHC) molecule, MHC-related molecule 1 (MR1). MAIT cells are present in human blood (1-8% of T cells), mesenteric lymph nodes, liver, and intestinal mucosa. MAIT cells play a role in detecting and fighting off microbial infections
H1490	PerCP-Cy5.5 Human TCR α/β Antibody [IP26]	TCR α/β is a monomorphic determinant of the α/β T-cell receptor, which is expressed on over 95% of normal peripheral blood CD3+ T cells. The α/β T-cell receptor (TCR) plays a crucial role in recognizing peptides bound to MHC molecules, leading to T-cell activation.
G1595	PerCP-Cy5.5 Human/Mouse Integrin β7 Antibody [FIB504]	Integrin β7 is a 130 kD glycoprotein also known as integin βp. It is a member of the Ig superfamily. In association with integrin α4 or αE chain, β7 forms α4/β7 or αE/β7 heterodimer. α4/β7 (CD49d/β7, LPAM-1) is expressed on the majority of peripheral lymphocytes, on small subsets of thymocytes, and bone marrow progenitors. LPAM-1 binds to several ligands, VCAM-1, MAdCAM-1 and fibronectin, and is involved in lymphocyte adhesion and some hematopoietic progenitor cells migration. αE/β7 (CD103/β7,αIEL/β7) is expressed on intestinal intraepithelial lymphocytes (IEL), dendritic epidermal T cells, T regulatory cells, a subset of CD8+ T cells in lymph nodes and lamina propria. CD103/β7 complex is thought to play a role in lymphocyte retention via i
H0125	PerCP-Cy5.5 IFN-gamma Antibody [4S.B3]	IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor and immune interferon that is produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemagglutinin, and other cytokines. IFN gamma is a dimeric protein consisting of two 146 amino acid subunits. IFN gamma is a glycoprotein that exists functionally as a homodimer of approximately 45 kDa. On SDS-PAGE, IFN gamma appears as a combination of 25, 20, and minor 15.5 kDa bands as a result of differential glycosylation. The biological activity of the IFN gamma homodimer is highly species specific. Human IFN gamma does not show cross-reactivity with mouse. IFN gamma exhibits functions such as a
G1910	PerCP-Cy5.5 IL-12/IL-23 p40 Antibody [C17.8]
G0185	PerCP-Cy5.5 IL-17A Antibody [G2J2]
G1925	PerCP-Cy5.5 IL-6 Antibody [MQ2-13A5]
G0365	PerCP-Cy5.5 Ly-6A/E/Sca-1 Antibody [D7]	Stem Cell Antigen-1 (Sca-1) is a member of the lymphocyte antigen 6 (Ly-6) family. It is expressed on multipotent hematopoietic stem cells (HSC) and is used as a marker of HSC in mice. Sca-1 is used in combination with lineage depletion antibodies to identify murine HSC. Sca-1 can be found in fetal liver, adult bone marrow, and adult peripheral blood and spleen. Sca-1 may be involved in the regulation of B and T cell activation.
G1955	PerCP-Cy5.5 Mouse CD104 Antibody [346-11A]
G1400	PerCP-Cy5.5 Mouse CD106 Antibody [429 (MVCAM.A)]
G0440	PerCP-Cy5.5 Mouse CD107a Antibody [1D4B]
G2675	PerCP-Cy5.5 Mouse CD107b Antibody [M3/84]
G4115	PerCP-Cy5.5 Mouse CD138 Antibody [281-2]	CD138 (Syndecan-1) is a transmembrane proteoglycan containing both heparan sulfate and chondroitin sulfate chains. It binds to components of the extracellular matrix and plays a critical role in cell adhesion, proliferation, and signaling. CD138 is predominantly expressed on epithelial cells, where its presence is associated with normal epithelial architecture. It is also expressed on B lymphocytes during specific stages of differentiation, including precursor B cells in the bone marrow and antibody-secreting plasma cells, but is absent on mature peripheral B cells. This expression pattern implicates CD138 in B cell–matrix interactions. Its expression is regulated during embryonic development and is subject to tissue-specific structural pol
G0980	PerCP-Cy5.5 Mouse CD146 Antibody [ME-9F1]
G1535	PerCP-Cy5.5 Mouse CD16.2/FcγRIV Antibody [9E9]
G4235	PerCP-Cy5.5 Mouse CD16/CD32 Antibody [2.4G2]	CD16 and CD32 are expressed on B cells, monocytes/macrophages, NK cells, granulocytes, mast cells, and dendritic cells. These receptors bind to the Fc portion of antibody-antigen complexes and play a role in adaptive immune responses.
G3005	PerCP-Cy5.5 Mouse CD172a/SIRPα Antibody [P84]
G1085	PerCP-Cy5.5 Mouse CD185 Antibody [2G8]	The Rat Anti-Mouse CD185 (CXCR5) monoclonal antibody specifically binds to the mouse C-X-C Chemokine Receptor type 5, CXCR5. CXCR5 is also known as CD185, BLR1, NLR and MDR15. CXCR5 is a seven-transmembrane, G-protein-coupled receptor that is specific for the CXC chemokine, CXCL13/BLC/BCA-1. The expression of CXCR5 has been detected in spleen, lymph nodes, tonsils, brain, bone marrow, T cells, B cells, cerebrum, cerebellum, hippcampus and pituitary. In mouse spleen, CXCR5 was strictly expressed by mature B cells and a small subset of T lymphocytes. CXCR5 plays a role in directing the migration of B and T cells to B cell follicles with the spleen and certain other lymphoid tissues. The immunogen used to generate 2G8 hybridoma was a recombina
G4385	PerCP-Cy5.5 Mouse CD19 Antibody [1D3]	CD19, a B lymphocyte-lineage differentiation antigen and a 95-kDa transmembrane glycoprotein, is a member of the immunoglobulin superfamily and is expressed throughout B-lymphocyte development from the pro-B cell stage through mature B cells. Terminally differentiated plasma cells do not express CD19. On mature B cells, CD19 associates with CD21 (CR-2) and CD81 (TAPA-1), forming a multimolecular complex that synergizes with surface immunoglobulin to promote cellular activation. Studies in CD19-deficient mice suggest that the level of CD19 expression influences the generation and maturation of B cells in both bone marrow and peripheral tissues. B-1 lineage B cells, also called CD5+ B cells, are drastically reduced or absent in CD19-deficient
G1355	PerCP-Cy5.5 Mouse CD194/CCR4 Antibody [2G12]	Mouse CCR4 cDNA contains 1531 bp, and encodes a protein of 360 amino acids that is 85% identical to human CCR4. CCR4 binds CCL17 (TARG) and CCL22 (MDC). Naïve T cells, bearing receptors for cutaneous antigens, become activated in skin-draining lymph nodes and express cutaneous lymphocyte antigen (CLA), which confers to these cells the capacity to migrate into the skin to exert their normal effector functions (1). CCR4 and CCR10 play an important role in the ligand-mediated recruitment of T cells into the skin in mice and humans, specifically with regards to tethering, firm adhesion, and subsequent extravasation to the site of injury (2,3). CCR4 is expressed in cutaneous regulatory T cells (Tregs). These cells are crucial for the induction a
G3020	PerCP-Cy5.5 Mouse CD196/CCR6 Antibody [29-2L17]
G0815	PerCP-Cy5.5 Mouse CD21/CD35 Antibody [7G6]	This antibody recognizes an epitope shared by 145-150-kDa and 190-kDa complement receptor proteins, originally designated CR2 (CD21) and CR1 (CD35), respectively. In the mouse, CD21 and CD35 are expressed on the majority of peripheral B lymphocytes, on the majority of resident peritoneal macrophages and mast cells, on peripheral blood granulocytes after treatment with N-formyl-Met-Leu-Phe, and on follicular dendritic cells, but not on thymocytes, T cells, erythrocytes, or platelets. CD21 is a ligand-binding component of the CD19/CD21/CD81 signal-transduction complex associated with the antigen receptor on B lymphocytes. CD21/CD35 also co-localizes with CD19 on the surface of peritoneal mast cells. Cr2null mice display impaired inflammatory
G4205	PerCP-Cy5.5 Mouse CD25/IL-2Rα Antibody [PC61.5]
G2870	PerCP-Cy5.5 Mouse CD26 Antibody [H194-112]
G4640	PerCP-Cy5.5 Mouse CD3 Antibody [17A2]
G2240	PerCP-Cy5.5 Mouse CD301b/MGL2 Antibody [URA-1]
G1340	PerCP-Cy5.5 Mouse CD304 Antibody [3E12]
G1415	PerCP-Cy5.5 Mouse CD317 Antibody [927]
G0845	PerCP-Cy5.5 Mouse CD38 Antibody [90]
G4160	PerCP-Cy5.5 Mouse CD3epsilon Antibody [145-2C11]	CD3epsilon is a 20 kDa transmembrane cell-surface protein that belongs to the immunoglobulin superfamily. It is one of five polypeptide chains that combine to form the T cell receptor (TCR) complex. CD3ε is expressed on T lymphocytes, NK-T cells, and to varying degrees on developing thymocytes. CD3 plays critical roles in TCR signaling, T lymphocyte activation, and antigen recognition.
G4145	PerCP-Cy5.5 Mouse CD4 Antibody [GK1.5]	The CD4 antigen is a 55 kDa cell surface type I membrane glycoprotein belonging to the immunoglobulin superfamily. CD4 acts as a co-receptor which, in cooperation with the T cell receptor (TCR), interacts with class II MHC molecules displayed by antigen-presenting cells (APC). CD4 is expressed by the majority of thymocytes, most helper T cells, a subset of NK-T cells, and weakly by dendritic cells and macrophages. CD4 plays an important role in the development of T cells and is required for mature T cells to function optimally.
G4835	PerCP-Cy5.5 Mouse CD40L Antibody [MR-1]
G0860	PerCP-Cy5.5 Mouse CD41 Antibody [MWReg30]	CD41 is a transmembrane glycoprotein that is encoded by Itga2b. CD41 associates with Integrin β3 chain (gpIIIa or CD61) to form the gpIIb/IIIa (CD41/CD61) complex. CD41/CD61 is expressed on platelets, megakaryocytes, and early hematopoietic progenitors. The integrin complex binds to fibrinogen, fibronectin, vitronectin, von Willebrand factor, and thrombospondin. It is important for platelet adhesion and aggregation, and it may play a role in osteolytic tumor metastasis.
G1040	PerCP-Cy5.5 Mouse CD43 Activation-Associated Glycoform Antibody [1B11]
G0545	PerCP-Cy5.5 Mouse CD49b Antibody [HMα2]	CD49b is a 150 kD glycoprotein, also known as α2 integrin, VLA-2 α chain, Integrin α2 chain, and HMα2. It is a member of the integrin family, expressed on NK cells, a subset of splenic CD4+ T cells, NK-T cells, intestinal intraepithelial and lamina propria lymphocytes, epithelial cells, and platelets. By associating with CD29 (integrin β1 subunit), CD49b forms the VLA-2 (integrin α2β1 ) complex. It plays a critical role in both adhesion and lymphocyte activation. The primary ligands for CD49b are collagen, laminin, and fibronectin.
G1115	PerCP-Cy5.5 Mouse CD54 Antibody [YN1/1.7.4]
G2945	PerCP-Cy5.5 Mouse CD64 Antibody [X54-5/7.1]
G4415	PerCP-Cy5.5 Mouse CD86 Antibody [GL1]
G1490	PerCP-Cy5.5 Mouse CD88/C5aR Antibody [20/70]
G4850	PerCP-Cy5.5 Mouse CD8β Antibody [53-5.8]
G1055	PerCP-Cy5.5 Mouse CX3CR1 Antibody [SA011F11]	CX3CR1 is a 40 kD, G-protein coupled receptor, with seven transmembrane regions. CX3CR1 is expressed by resident and alternatively activated macrophages (M2), a subset of monocytes, dendritic cells (DCs), NK cells, a subset of memory T cells, and mast cells. CX3CR1 is involved in cell recruitment during inflammation and participates in cell adhesion and extravasation from blood vessels. Its ligand is CX3CL1, also known as fractalkine or neurotactin. CX3CR1 is also a coreceptor for HIV1 and variations in this gene leads to increased susceptibility to HIV. In the brain, it is expressed by glial cells, which interact with CX3CL1 expressed by neurons.
G4820	PerCP-Cy5.5 Mouse GM-CSF Antibody [MP1-22E9]
G1505	PerCP-Cy5.5 Mouse I-A[b] Antibody [AF6-120.1]
G0785	PerCP-Cy5.5 Mouse IL-10 Antibody [JES5-16E3]
G4220	PerCP-Cy5.5 Mouse IL-4 Antibody [11B11]	IL-4 (interleukin-4) is a multifunctional 14 kDa cytokine. IL-4 is mainly produced by activated Th2 and NK cells, with smaller contributions from mast cells and basophils. It signals via the IL-4Rα receptor. Once bound to its receptor, IL-4 promotes the proliferation of activated B and T cells and drives B cell differentiation into plasma cells. It also facilitates class switching to IgE in B cells and enhances MHC class II expression, while suppressing Th1 cell development, macrophage activity, IFNγ production, and IL-12 release by dendritic cells. IL-4, like other cytokines associated with Th2 responses, contributes to airway inflammation commonly seen in allergic asthma.
G4325	PerCP-Cy5.5 Mouse LAG-3 Antibody [C9B7W]
G1640	PerCP-Cy5.5 Mouse LAP/TGF-β1 Antibody [TW7-16B4]
G4310	PerCP-Cy5.5 Mouse LFA-1α/CD11a Antibody [M17/4]	LFA-1α (lymphocyte function-associated antigen 1 alpha), also known as integrin alpha L chain and CD11a, pairs with CD18 to form LFA-1, a 180 kDa integrin glycoprotein belonging to the integrin family. LFA-1 is expressed on the surface of all leukocytes, including lymphocytes, monocytes, macrophages, and granulocytes. It plays a central role in leukocyte intercellular adhesion through interactions with its ligands ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50), and also contributes to lymphocyte costimulatory signaling.
G4430	PerCP-Cy5.5 Mouse Ly6G Antibody [1A8]	Lymphocyte antigen 6 complex, locus G (Ly-6G), is a 21–25 kDa GPI-anchored protein expressed primarily on peripheral granulocytes and highly specific for neutrophils. Ly-6G serves as a robust marker for neutrophil identification and depletion in mice. Ly-6G modulates neutrophil migration and recruitment to sites of inflammation via interaction with β2 integrins. Its downregulation is associated with age-related functional decline in neutrophils.
G4805	PerCP-Cy5.5 Mouse OX40 Antibody [OX-86]
G4265	PerCP-Cy5.5 Mouse PD-L1 Antibody [10F.9G2]	PD-L1 (programmed death ligand 1), also known as B7-H1 or CD274, is a 40 kDa type I transmembrane protein that belongs to the B7 family of the immunoglobulin superfamily. PD-L1 is expressed on T lymphocytes, B lymphocytes, NK cells, dendritic cells, as well as IFNγ-stimulated monocytes, epithelial cells, and endothelial cells. PD-L1 binds to its receptor, PD-1, found on CD4 and CD8 thymocytes as well as activated T and B lymphocytes and myeloid cells. Engagement of PD-L1 with PD-1 leads to inhibition of TCR-mediated T cell proliferation and cytokine production. PD-L1 is thought to play an important role in tumor immune evasion. Induced PD-L1 expression is common in many tumors and results in increased resistance of tumor cells to CD8 T cell
G1670	PerCP-Cy5.5 Mouse TCR Vα2 Antibody [B20.1]
G4355	PerCP-Cy5.5 Mouse Ter-119 Antibody [TER-119]	TER-119 is a lineage marker for erythroid cells from early proerythroblast to mature erythrocyte stages in adult blood, spleen, and bone marrow. It is also present in yolk sac, and fetal and newborn liver. The TER-119 antigen is not expressed by cells of earlier erythroid development at BFU-e (blast-forming unit erythroid) stage or CFU-e (colony-forming unit erythroid) stage.
G4670	PerCP-Cy5.5 mouse/human CD11b Antibody [M1/70]
G2030	PerCP-Cy5.5 Mouse/rat CD81 Antibody [Eat-2]
G3890	PerCP-Cy5.5 Phospho-Zap-70 (Tyr319)/Syk (Tyr352) Antibody [L15L21]
G1295	PerCP-Cy5.5 Podoplanin Antibody [L7B2]	Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin type-1 glycoprotein with a 40-43 kDa molecular weight. Podoplanin is expressed in many tumors and normal cells, especially lymphatic epithelial cells and follicular DCs. Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. Podoplanin appears to serve as a ligand for CLEC-2 and expression is positively correlated with tumors expressing greater invasive and metastatic potential. Podoplanin is directly involved in cell migration, aids metastases formation and tumor cell invasion of tissue. Further, it has also been determined that
G4295	PerCP-Cy5.5 Rat IgG2a isotype control Antibody [2A3]
G0635	PerCP-Cy5.5 Rat IgG2a κ Isotype Control Antibody [eBR2a]
G4490	PerCP-Cy5.5 Rat IgG2b isotype Antibody [LTF-2]
G0890	PerCP-Cy5.5 Rat IgG2b kappa Isotype Control Antibody [eB149/10H5]
G0920	PerCP-Cy5.5 TCR gammadelta Antibody [J18P6]	TCR gamma/delta (T-cell receptor gamma/delta) are specialized T-cells in the immune system. The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflamm
G0290	PerCP-Cy5.5 TCR-β Antibody [H57-597]	The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system c
G0335	PerCP-Cy5.5 TNF-α Antibody [MP6-XT22]
E8226	perdenteriobutyl bromide	Perdenteriobutyl bromide is the deuterated form of 1-bromo-butane. 1-Bromo-butane is a biomaterial or organic compound that can be used in life science research.
E7478	Peretinoin	Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1. Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression. Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC50 of 9 μM.
E2867	perflexane	Perflexane (Perfluorohexane) is a fluoroalkane that function as a radioopaque medium and a non-polar solvent. It is used as a contrast agent for ultrasound imaging.
S3501	Perflubron	Perflubron (1-Bromoperfluorooctane, Perfluorooctyl bromide, Oxygent, PFOB) exhibits anti-inflammatory activity thus decreases cytokine production in human alveolar macrophages. Perflubron also attenuates oxidative damage to both biological and nonbiological systems which is independent of its anti-inflammatory properties.
F2444	Perforin Antibody [P20D17]
E7683	Pergolide	Pergolide (LY127809 (free base)) is an ergot-derived orally active dopamine receptor agonist. Pergolide can be used for Parkinson disease research.
S6959	Perhexiline maleate	Perhexiline maleate is a potent inhibitor of carnitine palmitoyltransferase 1 (CPT1) with IC50s of 77 μM and 148 μM for rat heart CPT1 and liver CPT1, respectively, and also inhibits carnitine palmitoyltransferase 2 (CPT2).
E3300	Pericarpium Zanthoxyli peel Extract	Pericarpium Zanthoxyli Peel Extract is the peel extract of Zanthoxylum chinensis, which contains mainly volatile oil, alkaloids, amides, other components are coumarin, lignin, fatty acids, flavonoids, etc., in addition to a small amount of amino acids and minerals.
S1037	Perifosine	Perifosine is a novel Akt inhibitor with IC50 of 4.7 μM in MM.1S cells, targets pleckstrin homology domain of Akt. Phase 3.
E3895	Perilla Frutescens Extract	Perilla Frutescens Extract is extracted from Perilla frutescens, which is used as an analgesic, anti-abortive agent, and sedative.
E3896	Perilla Leaf Extract	Perilla Leaf Extract is extracted from the leaves of Perilla frutescens, which is capable of inhibiting SARS-CoV-2 replication by inactivating the virion.
S3205	Perillaldehyde	Perillaldehyde (Perilladehyde, Perillal, PAE, PA), the main component of Perilla frutescens (a traditional medicinal antioxidant herb), inhibits BaP-induced AHR activation and ROS production, inhibits BaP/AHR-mediated release of the CCL2 chemokine, and activats the NRF2/HO1 antioxidant pathway.
S9006	Perillartine	Perillartine (Perilla sugar, Peryllartine) is a sweetener. Perillartine can activation of the Tas1r2 monomeric receptors of human, rhesus monkey and squirrel monkey but not mouse in a species-dependent manner.
S3853	Perillyl alcohol	Perillyl alcohol (Perilla alcohol, Isocarveol) is a monoterpene isolated from the essential oils of lavendin, peppermint, spearmint, cherries, celery seeds, and several other plants.
E6037	Perindopril	Perindopril (S-9490) is a brain-penetrating inhibitor of angiotensin-converting enzyme (ACE) with an IC50 of 0.048 μM for ACE-1. It exhibits anti-hypertensive, anti-inflammatory, and anti-fibrotic properties.
S1506	Perindopril Erbumine	Perindopril Erbumine (S9490-3) is a pro-drug and metabolized in vivo by hydrolysis of the ester group to form Perindoprilat, the biologically active metabolite, a potent ACE inhibitor with IC50 of 1.05 nM. Perindopril Erbumine is used for in vivo studies and Perindoprilat is recommened for in vitro research.
E2435	Perindopril L-Arginine	Perindopril L-Argininel is a prodrug that is metabolized in the liver to its active diacid metabolite perindoprilat, which is rapidly and extensively absorbed, and become one of the highest tissue angiotensin-converting enzyme (ACE) affinities among the ACE inhibitors.
F3854	Periostin Antibody [C16F13]
A5566	Periostin Rabbit Recombinant mAb	Periostin Rabbit Recombinant mAb detects endogenous level of total Periostin.
F3997	Peripherin Antibody [P7B12]
E3759	Periploca Sepium Extract	Periploca Sepium Extract is derived from Periploca sepium, which has traditionally been used in oriental medicine for treatment of rheumatoid arthritis (RA).
S9181	Periplocin	Periplocin (Periplocoside), extracted from the traditional herbal medicine cortex periplocae, has cardiac and anticancer activity. Periplocin could significantly boost proliferation, migration and stimulate collagen production in fibroblast L929 cells, which is dependent on activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase, and thus promoting wound healing.
S9168	Periplogenin	Periplogenin (Desoxostrophanthidin, 5-beta-Hydroxydigitoxigenin), isolated from Lagenaria siceraria, has potent anti-psoriatic effects in vitro and in vivo.
F4128	PERK Antibody [A22L11]
F0027	PERK Antibody [L1C15]	PERK,p-ERK
S6461	Permethrin	Permethrin(NRDC-143) is a synthetic Type I pyrethroidal neurotoxic pesticide that has been responsible for accidental animal deaths.
S5185	Perospirone	Perospirone (SM-9018 free base) is an orally active antagonist of 5-hydroxytryptamine2 (5-HT2) receptor, dopamine2 (D2) receptor and 5-HT1A receptor with Ki of 0.6 nM, 1.4 nM and 2.9 nM, respectively.
S4889	Perospirone hydrochloride	Perospirone (SM-9018) is an atypical or second-generation antipsychotic of the azapirone family that antagonizes serotonin 5HT2A receptors and dopamine D2 receptors. It also displays affinity towards 5HT1A receptors as a partial agonist.
E7194	Peroxidase, Horseradish	Peroxidase, Horseradish is an archetypal haem-containing enzyme that uses hydrogen peroxide or alkyl peroxides to catalyze oxidative reactions, including the hydroxylation and polymerization of aromatic compounds. It is commonly used as a detection enzyme in biochemical assays like ELISA, Western blotting, and immunohistochemistry, due to its ability to produce strong colorimetric or chemiluminescent signals for sensitive and specific detection.
A5379	Peroxiredoxin 2 Rabbit Recombinant mAb	Peroxiredoxin 2 Rabbit Recombinant mAb detects endogenous level of total Peroxiredoxin 2.
F1664	Peroxiredoxin 2/PRP Antibody [K23N23]	Peroxiredoxin 2/PRP,PRDX2
A5814	Peroxiredoxin 3 Rabbit Recombinant mAb	Peroxiredoxin 3 Rabbit Recombinant mAb detects endogenous levels of total Peroxiredoxin 3.
F3198	Peroxiredoxin 3/PRDX3 Antibody [E17K19]
S4731	Perphenazine	Perphenazine (Perphenazin, Trilafon, Etaperazine) is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.
A2008	Pertuzumab (anti-HER2)	Pertuzumab (anti-HER2), a humanized monoclonal antibody and the first in the class of agents called the HER2 dimerization inhibitors, impairs the ability of HER2 to bind to other members of the HER family, MW: 148 KD.
E3199	Petasites Japonicus Extract	Petasites Japonicus Extract is extracted from Petasites Japonicus, which has been used for the treatment of migraine and tension headache.
E7847	PETCM	PETCM is an activator of caspase-3 and acts as an cytochrome c (cyto c)-dependent manner. PETCM promotes Apaf-1 oligomerization and induces cell apoptosis in HeLa cells.
A2474	Petosemtamab (Anti-EGFR / LGR5)	Petosemtamab (Anti-EGFR/LGR5) is a highly potent bispecific antibody against EGFR (Kd 0.22 nM) and LGR5 (Kd 0.86 nM). It blocks the appearance of metastases and slows the growth of primary tumors in experimental cancer models. Petosemtamab can be used in the research of solid tumors, such as head and neck squamous cell carcinoma (HNSCC), metastatic colorectal cancer (CRC). MW: 145.5 KD.
S3342	Petroselinic acid	Petroselinic acid (PSA) is a positional isomer of oleic acid isolated from the vegetable oil of Coriandrum sativum fruits. Petroselinic acid can be used for the fermentation of new sophorolipids.
S7109	Pevonedistat (MLN4924)	MLN4924 is a small molecule inhibitor of Nedd8 activating enzyme (NAE) with IC50 of 4 nM.
E1953	Pevonedistat hydrochloride	Pevonedistat hydrochloride (MLN4924 hydrochloride) is a potent and selective inhibitor of NEDD8-activating enzyme (NAE) with an IC50 of 4.7 nM. It disrupts cullin-RING ligase-mediated protein degradation, leading to apoptotic cell death in human tumor cells through the deregulation of S-phase DNA synthesis.
F2617	PEX19 Antibody [P24A3]
S7818	Pexidartinib (PLX3397)	Pexidartinib (PLX3397) is an oral, potent multi-targeted receptor tyrosine kinase inhibitor of CSF-1R, Kit (c-Kit), and FLT3 with IC50 of 20 nM, 10 nM and 160 nM, respectively. Pexidartinib (PLX3397) induces apoptosis and necrosis with antitumor activity. Phase 3.
E6007	Pexidartinib Hydrochloride	Pexidartinib Hydrochloride is an oral tyrosine kinase inhibitor of colony-stimulating factor 1 receptor (CSF1R). It significantly reduces macrophage levels in adipose tissue without altering overall myeloid cell counts in mice. It also induces developmental and immunotoxic effects in zebrafish embryos by hyperactivating Wnt signaling.
S7799	Pexmetinib	Pexmetinib is a potent, orally bioavailable, dual p38 MAPK/Tie-2 inhibitor with IC50 of 4 nM/18 nM in a HEK-293 cell line. Phase 1.
E7953	PF 1022A	PF 1022A is a cyclooctadepsipeptide with broadspectrum anthelmintic properties produced by fermentation of the fungus Mycelia sterilia. PF 1022A is a channel-forming ionophore. PF 1022A showes strong anthelmintic activities against Ascaridia galli in chickens. PF 1022A also can be used for angiostrongyliasis research.
S6418	PF 429242	PF 429242 is known as a S1P inhibitor with an IC50 of 170 nM, showing no significant inhibition of trypsin, elastase, proteinase K, plasmin, kallikren, factor XIa, thrombin, or furin at concentrations up to 100 μM and only modest inhibition of urokinase (IC50 = 50 μM) and factor Xa (IC50 = 100 μM).
S2249	PF 4800567	PF 4800567 is a novel and potent inhibitor of casein kinase 1 epsilon (IC50=32 nM) with greater than 20-fold selectivity over casein kinase 1 delta(IC50=711 nM).
S9731	PF-00835231	PF-00835231 is a 3CL^pro (M^pro) inhibitor that may targets SARS-CoV-2 protease 3CL^pro as a potential new treatment for COVID-19.
E7928	PF-01247324	PF-01247324 is a selective and orally bioavailable Nav1.8 channel blocker with an IC50 of 196 nM for recombinant human Nav1.8 channel.
S1094	PF-04217903	PF-04217903 is a selective ATP-competitive c-Met inhibitor with IC50 of 4.8 nM in A549 cell line, susceptible to oncogenic mutations (no activity to Y1230C mutant). Phase 1.
S7211	PF-04418948	PF-04418948 is a potent and selective prostaglandin EP₂ receptor antagonist with IC50 of 16 nM. Phase 1.
S2421	PF-04457845	PF-04457845 (PF-4457845) is a potent, favorable selective inhibitor of Fatty acid amide hydrolase (FAAH) with IC50 of 7.2 nM and 7.4 nM for hFAAH and rFAAH, respectively. PF-04457845 covalently modifies the active-site serine nucleophile of FAAH with exquisite selectivity relative to other members of the serine hydrolase superfamily.
S7192	PF-04620110	PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.
S2743	PF-04691502	PF-04691502 (PF4691502) is an ATP-competitive PI3K(α/β/δ/γ)/mTOR dual inhibitor with K_i of 1.8 nM/2.1 nM/1.6 nM/1.9 nM and 16 nM in cell-free assays, little activity against either Vps34, AKT, PDK1, p70S6K, MEK, ERK, p38, or JNK. PF-04691502 induces apoptosis. Phase 2.
E2819	PF-04802367	PF-04802367 (PF-367) is a highly selective Glycogen synthase kinase-3 (GSK-3) inhibitor with IC50s of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay.
S2656	PF-04929113 (SNX-5422)	PF-04929113 (SNX-5422) is a potent and selective HSP90 inhibitor with K_d of 41 nM and induces Her-2 degradation with IC50 of 37 nM. Phase 1/2.
E2983	PF-04957325	PF-04957325 is a highly potent and selective inhibitor of PDE8, with IC50 values of 0.7 nM and 0.3 nM for PDE8A and PDE8B, respectively. PF-04957325 greatly potentiates steroidogenesis in wild type adrenal cells.
S0496	PF-04995274	PF-04995274 (PF-4995274) is a potent, high-affinity, orally active and partial agonist of serotonin 4 receptor (5-HT4R) with EC50 of 0.47 nM, 0.36 nM, 0.37 nM and 0.26 nM for human 5-HT4A/4B/4D/4E, respectively. As for rat 5-HT4S/4L/4E, the EC50 is 0.59 nM, 0.65 nM and 0.62 nM, respectively. PF-04995274 is brain penetrant and can be used for cognitive disorders associated with Alzheimer's disease.
S6672	PF-05175157	PF-05175157 is a broad-spectrum effective ACC inhibitor with IC50 of 27.0 nM, 33.0 nM, 23.5 nM and 50.4 nM for human ACC1, human ACC2, rat ACC1, and rat ACC2, respectively.
S6145	PF-05221304	PF-05221304 is an orally bioavailable, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), an enzyme that catalyzes the first committed step in de novo lipogenesis (DNL).
E1927	PF-05251749（CK1-IN-2）	PF-05251749 (CK1-IN-2, Compound Nr.4) is a potent, selective, brain-penetrant inhibitor of Casein Kinase 1 (CK1) in a concentration-dependent manner, with IC50 values of 33.1 nM for CK1d and 51.6 nM for CK1e. It also functions as an inducer of CYP3A, with the potential to treat circadian rhythm disruptions in Alzheimer's and Parkinson's diseases.
S8407	PF-06273340	PF-06273340 is a highly potent, kinases elective, well-tolerated pan-Trk inhibitor with IC50 values of 6, 4, 3 nM for TrkA, TrkB, Trk C, respectively.
S6648	PF-06282999	PF-06282999 is an orally bioavailable, irreversible inactivator of myeloperoxidase enzyme and is currently in clinical trials for the potential treatment of cardiovascular diseases.
S8335	PF-06409577	PF-06409577 is an orally bioavailable AMPK activator with EC50 of 7 nM for α1β1γ1 in the TR-FRET assay and it shows no detectable inhibition of hERG in a patch-clamp assay (100 μM) and was not an inhibitor (IC50 > 100 μM) of the microsomal activities of major human cytochrome P450 isoforms.
S9921	PF-06424439	PF-06424439 is a first orally bioavailable small-molecule inhibitor of DGAT2 with an IC50 of 14 nM.
S0849	PF-06446846	PF-06446846 is an orally active proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. PF-06446846 selectively inhibits translation of PCSK9 by stalling the 80S ribosome in the proximity of codon region.
E0116	PF-06446846 hydrochloride	PF-06446846 (PF846) Hydrochloride is an orally bioavailable and specific inhibitor of PCSK9 with an IC50 of 0.3 µM in Huh7 cells.
S8202	PF-06447475	PF-06447475 is a potent, selective, and brain penetrant LRRK2 kinase inhibitor with IC50 of 3 nM.
S9655	PF-06821497	PF-06821497 is a selective and orally active inhibitor of Zeste Homolog 2 (EZH2) with a Ki value <0.1 nM against mutant Y641N EZH2. It exhibits robust tumor growth inhibition.
S8657	PF-06840003	PF-06840003 (EOS200271) is a highly selective orally bioavailable IDO-1 inhibitor. Although it has moderate hIDO1 enzyme inhibition (IC50 0.41 μM), it is a highly efficient compound (LE 0.53, LipE 5.1), driven by its tight packing within the enzyme, as well as the high density of hydrogen bonds it forms with hIDO-1 despite its small size.
S0036	PF-06869206	PF-06869206 is a selective inhibitor of NPT2a (also referred to as NaPi2a or SLC34A1) with an IC50 of 380 nM.
S8816	PF-06873600	PF-06873600 is an inhibitor of cyclin-dependent kinase 2 (CDK2), CDK4, and CDK6 with Ki values of 0.1, 1.2, and 0.1 nM, respectively, blocks the phosphorylation of retinoblastoma protein (RB1), and limits the proliferation of OVCAR-3 ovarian cancer cells with EC50s of 19 and 45 nM, respectively.
S9615	PF-06928215	PF-06928215 is a high affinity inhibitor of cyclic GMP-AMP synthase (cGAS) with an IC50 of 4.9 μM.
E1785	PF-06952229	PF-06952229(UNII-1KKS7U3X86) is a selective, orally available inhibitor of the serine/threonine kinase TGF-β receptor 1 (TGF-β-R1). It inhibits pSMAD2 in both tumor and immune cells, reducing TGF-β signalling and reversing EMT in vitro. It modulates the tumor immune microenvironment and shows antitumor activity in mouse models.
E1495	PF-07220060 (CDK4/6-IN-6)	PF-07220060 (CDK4/6-IN-6) is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively.
E5816	PF-07265028	PF-07265028 is a potent and selective inhibitor of hematopoietic progenitor kinase 1 (HPK1/MAP4K1) with a Ki of <0.05 nM, and exhibits potent cellular activity, with a pSLP76 IC50 of 17 nM.
E1818	PF-07265807	PF-07265807(TAM&Met-IN-1) is a dual inhibitor of AXL and MER, which exhibits anti-tumor effects. It also enhances the function of dendritic cells to cross-prime CD8+ T cells.
E5970	PF-07853578	PF-07853578 (Example 11) is a degrader of Patatin-Like Phospholipase Domain-Containing Protein 3(PNPLA3) with an EC50 of 5.2 nM. It may be useful for the treatment and prevention of liver diseases, including fatty liver, nonalcoholic fatty liver disease (NALFD), nonalcoholic steatohepatitis (NASH), liver fibrosis, cirrhosis, and hepatocellular carcinoma.
S8224	PF-3644022	PF-3644022 is a potent freely reversible ATP-competitive inhibitor of MAPKAPK2 (MK2) with an Ki of 3 nM. PF-3644022 also potently inhibits TNFα production with an IC50 of 160 nM.
S2222	PF-3716556	PF 3716556 is a potent and selective P-CAB (potassium-competitive acid blocker), with pIC50 of 6.026 and 7.095 for the inhibition of porcine H⁺,K⁺-ATPase activity in ion-leaky and ion-tight assay, respectively, inhibits gastric acid secretion, displays no activity at Na⁺,K⁺-ATPase, used for the treatment of gastroesophageal reflux disease.
S7094	PF-3758309	PF-03758309 (PF-03758309) is a potent, ATP-competitive, pyrrolopyrazole inhibitor of PAK4 with Kd of 2.7 nM. PF-3758309 is antiproliferative and induces apoptosis in a HCT116 tumor model.
S2666	PF-3845	PF-3845 is a potent, selective and irreversible FAAH inhibitor with K_i of 230 nM, showing negligible activity against FAAH2.
S8361	PF-4136309	PF-4136309 (INCB8761, PF-04136309) is a potent, selective, and orally bioavailable CCR2 antagonist with an IC50 of 5.2 nM for human CCR2.
S7644	PF-431396	PF-431396 is a dual PYK2/FAK inhibitor with IC50 of 11 nM and 2 nM, respectively.
S2163	PF-4708671	PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with K_i/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. PF-4708671 induces autophagy. First S6K1-specific inhibitor to be reported.
S2904	PF-477736	PF-477736 (PF-736, PF-00477736) is a selective, potent and ATP-competitive Chk1 inhibitor with K_i of 0.49 nM in a cell-free assay and also inhibits VEGFR2, Aurora-A, FGFR3, Flt3, Fms (CSF1R), Ret and Yes. It shows ~100-fold selectivity for Chk1 than Chk2.
E7893	PF-4840154	PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel with EC50s of 97 and 23 nM, respectively. PF-4840154 elicits TrpA1-mediated nocifensive behaviour in mouse.
S2921	PF-4981517	PF-4981517 (CYP3cide, PF-04981517) is a potent and selective inhibitor of CYP3A4 (P450) with IC50 of 0.03 μM, exhibits >500-fold selectivity over CYP3A5 and CYP3A7.
S7675	PF-4989216	PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively.
S2777	PF-5274857	PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 and Ki of 5.8 nM and 4.6 nM, respectively, and can penetrate the blood–brain barrier.
E7015	PF-543	PF-543 (Sphingosine Kinase 1 Inhibitor II) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. PF-543 is >100-fold selectivity for SPHK1 over SPHK2. PF-543 is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC50 of 26.7 nM. PF-543 induces apoptosis, necrosis, and autophagy.
S7177	PF-543 hydrochloride	PF-543 hydrochloride, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and K_i of 2.0 nM and 3.6 nM, exhibits >100-fold selectivity over the SphK2 isoform. PF-543 hydrochloride induces apoptosis, necrosis, and autophagy.
S2890	PF-562271	PF-562271 (PF-00562271) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.
S2672	PF-562271 Besylate	PF-562271 Besylate is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Phase 1.
S7357	PF-562271 HCl	PF-562271 HCl is the hydrochloride salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Phase 1.
S2013	PF-573228	PF-573228 is an ATP-competitive inhibitor of FAK with IC50 of 4 nM in a cell-free assay, ~50- to 250-fold selective for FAK than Pyk2, CDK1/7 and GSK-3β. PF-573228 induces apoptosis.
S6499	PF-6260933	PF-6260933 (PF-06260933) is a potent inhibitor of MAP4K4 with an IC50 of 3.7 nM, possessing excellent kinome selectivity.
S6734	PF-670462	PF-670462 is a potent and selective inhibitor of CK1ε and CK1δ with IC50 value of 90 nM and 13 nM, respectively.
E0146	PF-9363	PF-9363 is a potent and selective KAT6A/6B inhibitor with Ki of 0.41 nM and 1.2 nM for KAT6A and KAT6B, respectively. PF-9363 displays potent anti-tumor activity in ER+ breast cancer models.
S0435	PF-9366	PF-9366 is a human methionine adenosyltransferase 2A (MAT2A) inhibitor with IC50 of 420 nM and Kd of 170 nM.
E8166	PF429242 dihydrochloride	PF429242 dihydrochloride is a reversible and competitive SREBP site 1 protease (S1P) inhibitor with an IC50 of 175 nM.
E0788	PfDHODH-IN-2	PfDHODH-IN-2, a dihydrothiophenone derivative, is a potent Plasmodium falciparum dihydroorotate dehydrogenase (pfDHODH) inhibitor with an IC50 of 1.11 µM, acting as an antimalarial agent which can be used for the research of malaria.
E0998	PFE-360	PFE-360(PF-06685360) is a brain-penetrant and selective LRRK2 small-molecule kinase inhibitors.
S1216	PFI-1 (PF-6405761)	PFI-1 (PF-6405761) is a highly selective BET (bromodomain-containing protein) inhibitor for BRD4 with IC50 of 0.22 μM and for BRD2 with IC50 of 98 nM in a cell-free assay.
E7474	PFI-2	PFI-2 ((R)-PFI-2 hydrochloride) hydrochloride is a potent and selective SET domain containing lysine methyltransferase 7 (SETD7) inhibitor. (R)-PFI-2 shows high inhibiting activity with IC50 value of 2.0 nM and (S)-PFI-2 shows inhibiting activity with IC50 value of 1.0 μM. PFI-2 hydrochloride can be used for the research of chronic kidney disease and inflammation response in the development of renal fibrosis.
S7294	PFI-2 HCl	PFI-2 is a potent, selective, and cell-active lysine methyltransferase SETD7 inhibitor with K_{i (app)} and IC50 of 0.33 nM and 2 nM, 1000-fold selectivity over other methyltransferases and other non-epigenetic targets.
S7315	PFI-3	PFI-3 is a selective chemical probe for SMARCA bromodomains, including SMARCA2, SMARCA4 and PB1(5) bromodomains.
S7906	PFI-4	PFI-4 is a potent and selective BRPF1 bromodomain inhibitor with IC50 of 80 nM.
E4657	PFI-6	PFI-6 is a selective MLLT1/3 probe that targets the YEATS domain of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3) with IC50 values of 140 nM and 160 nM for MLLT1 and MLLT3, respectively. PFI-6 demonstrates increased affinity and selectivity for MLLT1/3 than other human YEATS domain proteins (YEATS2/4).
S9882	PFI-90	PFI-90 is a selective inhibitor of the histone demethylase KDM3B. PFI-90 induces apoptosis and cell differentiation resulting in delayed tumor progression in vivo.
S7289	PFK15	PFK15 (PFK-015) is a potent and selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM.
S8807	PFK158	PFK158 is a potent and selective inhibitor of PFKFB3. It has improved PK properties and causes ~80% growth inhibition in several mouse models of human-derived tumors.
F5036	PFKFB2 Antibody [P13H13]
F4675	PFKFB3 Antibody [A21K14]
F1204	PFKFB3 Antibody [M5H12]	6 Phosphofructo 2 Kinase,PFKFB3
F3155	PFKM + PFKL Antibody [K8F12]
F3597	PFKM + PFKP Antibody [B11E20]
F2565	PFKM Antibody [F13D16]	PFK-1,PFKM
F0698	PFKP Antibody [E13C9]
S3549	PFM01	PFM01, a cell-permeable N-alkylated Mirin derivative, is a selective inhibitor of MRE11 endonuclease activity.
F1652	PGC 1β Antibody [N23E23]	Peroxisome proliferator-activated receptor gamma coactivator 1-beta, PGC-1-beta, PGC-1-β, PPAR-gamma coactivator 1-beta; PPARGC-1-beta, PGC-1-related estrogen receptor alpha coactivator, PPARGC1B, PERC, PGC1, PGC1B, PPARGC1
F4188	PGC-1α Antibody [J17F10]
F4416	PGC1α/β Antibody [H5N22]
F1626	PGK1 Antibody [D17A1]
F1137	PGP9.5 Antibody [L3K10]	PGP9.5,Protein Gene Product 9.5,UCHL1,UCH-L1/PGP9.5
F1408	PGRMC1 Antibody [F1M7]
S0082	PH-002	PH-002 is an inhibitor of Apolipoprotein E4 (ApoE4) intracellular domain interaction in nerve cells.
S3451	PH-064	PH-064 (BIM-46187) is a novel imidazo-pyrazine derivative that inhibits the heterotrimeric G-protein complex effectively. PH-064 (BIM46174) inhibits heterotrimeric G-protein signalling in GPCRsthat mediate cyclic AMP generation (GAs), calcium release (GAq), cancer cell invasion by Wnt-2 frizzled receptors, and high-affinity neurotensin receptors (GAo/i and GAq).
S2726	PH-797804	PH-797804 is a novel pyridinone inhibitor of p38α with IC50 of 26 nM in a cell-free assay; 4-fold more selective versus p38β and does not inhibit JNK2. Phase 2.
S1070	PHA-665752	PHA-665752 is a potent, selective and ATP-competitive c-Met inhibitor with IC50 of 9 nM in cell-free assays, >50-fold selectivity for c-Met than RTKs or STKs.
S1454	PHA-680632	PHA-680632 is a potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3.
E7241	PHA-767491	PHA-767491 is a dual Cdc7/Cdk9 inhibitor, with IC50s of 10 nM and 34 nM, respectively.
S2742	PHA-767491 HCl	PHA-767491 (CAY10572, NMS 1116354) HCl is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 nM in cell-free assays, respectively.It displays ~20-fold selectivity against CDK1/2 and GSK3-β, 50-fold selectivity against MK2 and CDK5, 100-fold selectivity against PLK1 and CHK2.
S1487	PHA-793887	PHA-793887 is a novel and potent inhibitor of CDK2, CDK5 and CDK7 with IC50 of 8 nM, 5 nM and 10 nM. It is greater than 6-fold more selective for CDK2, 5, and 7 than CDK1, 4, and 9. PHA-793887 induces cell-cycle arrest and apoptosis. Phase 1.
E6459	Phaclofen	Phaclofen is a selective antagonist of GABAB receptor. Phaclofen is a peripheral and central baclofen antagonist that is used in determining the physiological significance of central and peripheral bicuculline-insensitive receptors with which GABA and (-)-baclofen interact.
S8204	Phalloidin	Phalloidin is a mushroom-derived toxin which can be used to label F-actin of the cytoskeleton with fluorochrome .
E3556	Pharbitis Extract	Pharbitis Extract is extracted from Pharbitis nil, which has pharmacological activity against Asthma.
E7968	Phaseollin	Phaseollin is an isoflavonoid phytoalexin that can be isolated from Phaseolus vulgaris . Phaseollin is toxic to bean hypocotyl and endocarp cells, and causes a complete lysis of sheep erythrocytes.
S3240	Phaseoloidin	Phaseoloidin, a homogentisic acid glucoside from Nicotiana attenuata trichomes, contributes to the plant's resistance against lepidopteran herbivores. Phaseoloidin has anti-complement effects.
E3450	Phaseolus radiatus seed Extract	Phaseolus Radiatus Seed Extract is extracted from the seeds of Vigna radiata, which has antioxidant activity.
F1345	PHB2 Antibody [F9A16]	PHB2,Prohibitin 2
E2168	PHD-1-IN-1	PHD-1-IN-1 is an orally active and potent HIF prolylhydroxylase domain-1 (PHD-1) inhibitor with an IC50 of 0.034 μM
F0587	PHD-2/Egln1 Antibody [C1P15]	EGLN1/PHD2,PHD-2/Egln1
A5251	PHD1/prolyl hydroxylase Rabbit Recombinant mAb	PHD1/prolyl hydroxylase Rabbit Recombinant mAb detects endogenous level of total PHD1/prolyl hydroxylase.
E3596	Phellinus linteus Extract	Phellinus Linteus Extract is extracted from Phellinus Linteus, which has immunomodulatory effect.
S9172	Phellodendrine	Phellodendrine, a quaternary ammonium alkaloid extracted from the dried bark of Phellodendrom chinensis Schneid and Phellodendrom amurense Rupr, has the effect of suppressing cellular immune response, reducing blood pressure and antinephritis.
S9245	Phellodendrine chloride	Phellodendrine chloride, isolated from the Phellodrndron amurensis, exhibits immunosuppressive and anti-inflammatory activities.
E3306	Phellodendron amurense bark Extract	Phellodendron Amurense Bark Extract (Nexrutine), isolated from the barks of Phellodendron amurense, has shown a favorable effect on prostate cancer in vivo and in vitro.
E1070	Phen-DC3 Trifluoromethanesulfonate	Phen-DC3 Trifluoromethanesulfonate is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC50s of 65 ± 6 and 50 ± 10 nM, respectively.
S2577	Phenacetin	Phenacetin (Acetophenetidin) is a non-opioid analgesic without anti-inflammatory properties.
E6460	Phenamil methanesulfonate	Phenamil methanesulfonate, is a potent and less reversible inhibitor of epithelial sodium channel (ENaC) with an IC50 of 400 nM. Phenamil methanesulfonate is also a competitive inhibitor of TRPP3 and inhibits TRPP3-mediated Ca2+ transport with an IC50 of 140 nM in a Ca2+ uptake assay. Phenamil methanesulfonate is used for the research of cystic fibrosis lung disease.
E7375	Phenanthrene	Phenanthrene is an orally active polycyclic aromatic hydrocarbon (PAH) that induces inflammation, oxidative stress, and apoptosis. Additionally, phenanthrene is commonly used to detect or assess PAH pollution in the environment.
S5037	Phenazine methosulfate	Phenazine methosulfate (N-Methylphenazonium methosulfate, 5-Methylphenazinium methyl sulfate) is widely used as an intermediate electron carrier for coupling the production of NADH or NADPH to the reduction of tetrazolium salts to coloured formazans.
S4235	Phenazopyridine HCl	Phenazopyridine HCl is a local analgesic that has been used in urinary tract disorders. It is an inhibitor of sodium channel protein type 1 subunit alpha.
E0165	Phenelzine sulfate	Phenelzine Sulfate is a hydrazine derivative and acts as a potent non-selective monoamine oxidase (MAO) inhibitor with an IC50 of 0.9 μM.
S3703	Phenethyl alcohol	Phenethyl alcohol (2-phenylethanol, 2-Phenylethyl alcohol, Benzeneethanol, Phenylethanol) is an antimicrobial, antiseptic, and disinfectant that is used also as an aromatic essence and preservative in pharmaceutics and perfumery.
S2542	Phenformin HCl	Phenformin HCl is a hydrochloride salt of phenformin that is an anti-diabetic drug from the biguanide class. It activates AMPK, increasing activity and phosphorylation.
S4892	Phenibut	Phenibut (Aminophenylbutyric acid, Fenibut, Phenigam, Phenybut, PhGABA, β-Phenyl-γ-aminobutyric acid, β-Phenyl-GABA), a GABA analogue, is a central nervous system depressant with anxiolytic and sedative effects.
S5520	Phenidone	Phenidone (1-phenyl-3-pyrazolidinone), a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), is an organic compound that is primarily used as a photographic developer.
S1921	Phenindione	Phenindione (Rectadione, phenylindandione) is an anticoagulant which functions as a Vitamin K antagonist.
S4045	Pheniramine Maleate	Pheniramine Maleate is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria.
E7437	Phenol Red	Phenol red (Phenolsulfonephthalein) is a pH indicator dye commonly used in cell culture media, where it changes color from yellow to red based on pH levels. It also participates in redox reactions, particularly in the presence of enzymes like myeloperoxidase, influencing cellular oxidative states without directly causing significant toxicity.
S4418	Phenol Red sodium salt	Phenol Red sodium salt (Phenolsulfonephthalein sodium salt) is used ubiquitously as a pH indicator in tissue culture media ranging from 6.8 (yellow) to 8.2 (red). Phenol red binds to the estrogen receptor of MCF-7 human breast cancer cells.
E8221	phenol-d6	Phenol-d6 is a deuterated form of phenol. Phenol is a disinfectant preservative with a broad spectrum of antibacterial properties.
S5395	Phenolphthalein	Phenolphthalein (Phthalimetten) is an acid-base pH indicator.
S4251	Phenothiazine	Phenothiazine (ENT 38) is a dopamine-2 (D2) receptor antagonist therefore decreases the effect of dopamine in the brain.
L8500	Phenotypic Screening Library	A unique collection of 4209 bioactive compounds with identified targets used for phenotypic Screening.
S9634	Phenoxodiol (Haginin E)	Phenoxodiol (Haginin E, Idronoxil, Dehydroequol, NV 06, PXD) is an isoflavone analog with antineoplastic activity that activates the caspase system, inhibits XIAP (X-linked inhibitor of apoptosis), and disrupts FLICE inhibitory protein (FLIP) expression, resulting in tumor cell apoptosis. Phenoxodiol also inhibits DNA topoisomerase II.
S2499	Phenoxybenzamine HCl	Phenoxybenzamine HCl (NSC 37448, NCI-c01661) is a non-specific, irreversible alpha antagonist with an IC50 of 550 nM.
S2188	Phenprocoumon	Phenprocoumon (Marcoumar, Marcumar and Falithrom,Ro 1-4849) is a vitamin K reductase with an IC50 of 1 μM
E4863	Phentolamine	Phentolamine is a potent, selective and orally active α1 adrenergic and α2 adrenergic receptor antagonist. Phentolamine can be used for the research of erectile dysfunction.
E6046	phentolamine hydrochloride	Phentolamine hydrochloride is a potent, selective, and orally active antagonist of α1 and α2 adrenergic receptors , with pKi values of 8.8, 8.0, and 8.3 for the human α2A, α2B, and α2C adrenergic receptors, respectively. It also shows binding affinities for the α1-adrenoceptor subtypes, exhibiting Ki values of 6.1 nM for cloned α1A/D, 39.8 nM for α1B, and 2.8 nM for α1C.
S2038	Phentolamine Mesylate	Phentolamine Mesylate(Phentolamine methanesulfonate) is a reversible and nonselective alpha-adrenergic receptor antagonist, used for the prevention or control of hypertensive episodes.
S6051	Phenyl-ac-Gly-OH	Phenyl-ac-Gly-OH (N-(2-Phenylacetyl)glycine, 2-Phenylacetyl glycine, Phenaceturic acid, Phenacetylglycine) is one of acyl glycines that are normally minor metabolites of fatty acids.
E8233	Phenyl-d5-boronic acid	Phenyl-d5-boronic acid is the deuterated form of phenylboronic acid. Phenylboronic acid is a biochemical reagent.
S9357	Phenylacetaldehyde	Phenylacetaldehyde (Hyacinthin, Phenylethanal) is an organic compound used in the synthesis of fragrances and polymers.
S6076	Phenylacetylglutamine	Phenylacetylglutamine is a product formed by the conjugation of phenylacetate and glutamine. It is a normal constituent of human urine, but other mammals such as the dog, cat, rat, monkey, sheep, and horse do not excrete this compound.
E7645	Phenylacetylglutamine-d5	Phenylacetylglutamine-d5 is the deuterium labeled Phenylacetylglutamine. Phenylacetylglutamine is a colonic microbial metabolite from amino acid fermentation.
E4016	Phenylarsine oxide	Phenylarsine oxide (Oxophenylarsine) is a membrane-permeable protein tyrosine phosphatase inhibitor with IC50 18 µM. It Stimulates 2-deoxyglucose transport in insulin-resistant human skeletal muscle.
S1654	Phenylbutazone	Phenylbutazone (Butazolidine) is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis.
S2569	Phenylephrine HCl	Phenylephrine HCl is a selective α1-adrenergic receptor agonist, used primarily as a decongestant.
S5425	Phenylglyoxal hydrate	Phenylglyoxal (1-Phenylethanedione) is a potent inhibitor of mitochondrial aldehyde dehydrogenase. It reacts with arginine residues in purified Hageman factor (HF, Factor XII) and causes inhibition of its coagulant properties.
S6053	Phenylglyoxylic acid	Phenylglyoxylic acid (Benzoyl formate, Phenylglyoxalic acid, Phenylglyoxylate) is a key building block in the field of chemical synthesis and is widely used to synthesize pharmaceutical intermediates or food additives.
S2525	Phenytoin	Phenytoin (Di-Hydan, Dihycon, Dilabid, Diphedan, Diphenat, Diphenylan, Diphenylhydantoin, Hydantol, Lehydan, NSC 8722) is an inactive voltage-gated sodium channel stabilizer.
S2524	Phenytoin Sodium	Phenytoin Sodium (Aleviatin, Diphenylhydantoin sodium, Eptoin, Phenytoin soluble, Prompt; Phenytek,Dilantin sodium, Diphantoine) is an inactive voltage-gated sodium channel stabilizer.
E3149	Pheretima Extract	Pheretima Extract is extracted from Pheretima, which has effects on various inflammatory diseases such as asthma, cough, and fever.
S5348	Pherocon (4-(4-Acetoxyphenyl)-2-butanone)	Pherocon (4-(4-Acetoxyphenyl)-2-butanone, 4-(p-Acetoxyphenyl)-2-butanone, 4--(3-Oxobutyl)phenyl acetate) is a standard melon fly attractant for detection programs.
F3416	PHF1 Antibody [M20F24]
F2637	PHF20 Antibody [B7L16]
A5920	PHF8 Rabbit Recombinant mAb	PHF8 Rabbit Recombinant mAb detects endogenous levels of total PHF8.
F1406	PHGDH Antibody [M2L10]	PHGDH,PHGDH/Malate dehydrogenase
E1437	PHI-101	PHI-101 is an orally active, potent third-generation inhibitor of FLT3 that overcomes resistance to multiple drug-resistant mutations. It has potential for research in relapsed or refractory acute myeloid leukemia (AML).
E3550	Philippine flemingia root Extract	Philippine Flemingia Root Extract is extracted from the root of Philippine Flemingia.
S9187	Phillygenin	Phillygenin (Sylvatesmin), a bioactive intergradient in Osmanthus fragrans, has anti-inflammatory, anti-obesity and antipyretic activities. It could reduce blood lipid levels and low density lipoprotein.
S8418	Phleomycin D1	Phleomycin D1(PLM D1), a glycopeptide antibiotic, is a member of the Bleomycin/Phleomycin family. It causes cell death by binding and cleaving DNA. It shows antiproliferative activities and strong cytotoxicity against HT-29 cells.
S4784	Phloracetophenone	Phloracetophenone, or 2,4,6-trihydroxyacetophenone (THA), the aglycone component of phloracetophenone glucoside, is a naturally occurring compound obtained from the rhizome of Curcuma comosa (Family Zingiberaceae). Phloracetophenone can stimulate CYP7A1 activity. Phloracetophenone induces cholestasis in rats mediated through Mrp2.
S3795	Phloretic acid	Phloretic acid (Desaminotyrosine, Hydro-p-coumaric acid, Phloretate, 3-(4-Hydroxyphenyl)propanoic acid) is a naturally occurring phenolic compound which can be produced by the hydrogenation of p-coumaric acid or synthesized from phloretin, a by-product of apple tree leaves.
S2342	Phloretin (RJC 02792)	Phloretin (RJC 02792, NSC 407292, Dihydronaringenin) is a dihydrochalcone found in apple tree leaves, which shows beneficial effects on diabetes.
S2343	Phlorizin	Phlorizin (Phloridzin) is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees. Phlorizin is a non-selective SGLT inhibitor with Ki of 300 nM and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na+/K+-ATPase inhibitor.
S9389	Phorbol	Phorbol is a natural, plant-derived organic compound that exerts a broad range of biological activities.
E7637	Phorbol 12,13-dibutyrate	Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator and a potent skin tumor promoter.
E2961	Phosphatase substrate	Phosphatase substarte (4-Nitrophenyl phosphate disodium hexahydrate, p-nitrophenyl phosphate disodium hexahydrate) is widely used as a small molecule phosphotyrosine-like substrate in activity assays for protein tyrosine phosphatases. It is a colorless substrate that upon hydrolysis is converted to a yellow 4-nitrophenolate ion that can be monitored by absorbance at 405 nm.
E7211	Phosphatidylcholines,soya	Phosphatidylcholines,soya is a phosphatidylcholine from soybean used in the preparation of liposomes. Phosphatidylcholines,soya can be used as a vehicle in animal agent administration.
S3335	Phospho(enol)pyruvic acid monopotassium salt	Phospho(enol)pyruvic acid monopotassium salt (Potassium 1-carboxyvinyl hydrogenphosphate) is an endogenous metabolite.
F3048	Phospho-(Ser) 14-3-3 Binding Motif Antibody [P9J15]
F4182	Phospho-4E-BP1 (Ser65) Antibody [K24A12]
F0339	Phospho-4E-BP1 (Ser65) Antibody [K8A20]	p-4E-BP1
F0851	Phospho-4E-BP1 (Thr70) Antibody [K18C18]
F3507	Phospho-Akt (Ser473) Antibody [B19D19]	p-Akt1/2/3,phospho akt1/pkbalpha (ser473),Phospho-Akt (Ser473)
F0699	Phospho-Akt (Thr450) Antibody [J1B12]	RAC-beta serine/threonine-protein kinase, Protein kinase Akt-2, PKB beta 1, RAC-PK-beta, RAC-gamma serine/threonine-protein kinase, Akt-3, PKB gamma, RAC-PK-gamma, STK-2, AKT3, PKBG, RAC-alpha serine/threonine-protein kinase, PKB, PKB alpha, Proto-oncogene c-Akt, RAC-PK-alpha, AKT1
F2636	Phospho-Akt1 (Ser129) Antibody [N19C7]	AKT1 (phospho S129),Phospho-Akt1 (Ser129)
F4087	Phospho-Akt1 (Ser473) Antibody [K10L8]
F1644	Phospho-AKT1/2/3 (Ser473/474/472) Antibody [B6L18]
F0493	Phospho-Akt2 (Ser474) Antibody [L16H11]	AKT2 (phospho S474),Phospho-Akt2 (Ser474)
F4092	Phospho-AMPA Receptor 1 (GluA1) (Ser831) Antibody [D9B24]
A5194	Phospho-AMPK alpha 1 (S496) Rabbit Recombinant mAb	Phospho-AMPK alpha 1 (S496) Rabbit Recombinant mAb detects endogenous level of total phospho-AMPK alpha 1 (S496).
A5957	Phospho-AMPK alpha 2 (S491) Rabbit Recombinant mAb	Phospho-AMPK alpha 2 (S491) Rabbit Recombinant mAb detects endogenous levels of phosphorylated AMPK alpha 2 (S491).
F1561	Phospho-AMPK α1/α2 (Thr183/172) Antibody [C21K7]
F3514	Phospho-AMPKα (Thr172) Antibody [E15N20]
F0591	Phospho-AMPKα1 (Ser485) Antibody [E13G1]
F1967	Phospho-AP2M1 (Thr156) Antibody [H5H7]	AP2M1 (phospho T156),Phospho-AP2M1 (Thr156)
F0768	Phospho-APP (Thr668) Antibody [F3G1]
F1382	Phospho-AS160 (Ser318) Antibody [F11E8]
F0748	Phospho-AS160 (Ser588) Antibody [A11K10]
F2944	Phospho-ATF1 (Ser63) Antibody [P2B10]
F2830	Phospho-ATF2 (Thr71) Antibody [F15L17]	p-ATF-2
F2435	Phospho-ATR (Ser428) Antibody [H24J12]	ATR (phospho S428),Phospho-(Ser/Thr) Akt Substrate,Phospho-ATR (Ser428)
F0241	Phospho-Aurora A/B/C (T288/232/198) Antibody [H12A24]	Aurora 3,Aurora/IPL1-related kinase 3, ARK-3, ARK3, Aurora/IPL1/Eg2 protein 2, STK13, Serine/threonine-protein kinase 13, Serine/threonine-protein kinase aurora-C, Aurora 1, AIM-1, ARK-2, ARK2, Aurora-related kinase 2, AURKC, AIE2, AIK3, AIRK3, ARK3, STK-1, Serine/threonine-protein kinase 12, AURKB, AIK2, AIRK2, STK1, STK12, STK5, Aurora 2, Aurora/IPL1-related kinase 1, ARK-1, Aurora-related kinase 1, Breast tumor-amplified kinase, Ipl1- and aurora-related kinase 1, Serine/threonine-protein kinase 15, AURKA, AIK1, AIRK1, ARK1, AURA, AYK1, BTAK, IAK1, STK15, STK6, Aurora- and IPL1-like midbody-associated protein 1, Aurora/IPL1-related kinase 2
F0592	Phospho-Axl (Tyr702) Antibody [F18P21]
F2054	Phospho-B MyB (Thr487) Antibody [B21K19]
F0445	Phospho-Bad (Ser112) Antibody [K3H8]	Bad (phospho S112),Phospho-Bad (Ser112)
F0405	Phospho-c-Fos (Ser32) Antibody [H14J15]
F1069	Phospho-c-Jun (Ser63) Antibody [A1M19]	c-Jun (phospho S63),c-Jun (phospho S73),p-c-Jun,Phospho-c-Jun (Ser63),Phospho-c-Jun (Ser63) II,Phospho-c-Jun (Ser73)
F4072	Phospho-c-Jun (Ser63) Antibody [E24K1]
F3070	Phospho-c-Jun (Ser73) Antibody [H24P6]
F1606	Phospho-c-Myb (Ser11) Antibody [B4K10]
F1220	Phospho-c-Myc (Ser62) Antibody [F8C4]	c-Myc (phospho S62),MYC (phospho S62),Phospho-c-Myc (Ser62)
F0353	Phospho-c-Raf (Ser338) Antibody [F15C8]
F0342	Phospho-CaMKII (Thr286) Antibody [L21H4]	Calcium/calmodulin-dependent protein kinase type II subunit beta, Calcium/calmodulin-dependent protein kinase type II subunit delta, Calcium/calmodulin-dependent protein kinase type II subunit gamma, Calcium/calmodulin-dependent protein kinase type II subunit alpha, CaM kinase II subunit beta, CaMK-II subunit beta, CAMK2B, CAM2, CAMK2, CAMKB, CaM kinase II subunit delta; CaMK-II subunit delta, CAMK2D, CAMKD, CaM kinase II subunit gamma; CaMK-II subunit gamma, CAMK2G, CAMK, CAMK-II, CAMKG,CaM kinase II subunit alpha, CaMK-II subunit alpha, CAMK2A, CAMKA, KIAA0968, CaMK-II β, CaMK-II δ, CaMK-II γ, CaMK-II α
F3156	Phospho-CD3 ζ (Tyr142) Antibody [N6L15]
F2899	Phospho-CD3 ζ (Tyr83) Antibody [G11P19]
F0306	Phospho-cdc2 (Tyr15) Antibody [P12H8]	CDK1 (phospho Y15),Phospho-cdc2 (Tyr15)
F3558	Phospho-CDC2(Thr161) Antibody [F10B10]
F1949	Phospho-cdc25C (Thr48) Antibody [G24N3]
F4240	Phospho-CDC37 (Ser13) Antibody [G22K18]
F3185	Phospho-CDK1 (T161) + CDK2/3 (T160) Antibody [G17G2]
F2120	Phospho-CDK1/2/3 (Thr14) Antibody [L12G24]	Cyclin-dependent kinase 1, CDK1, Cell division control protein 2 homolog, Cell division protein kinase 1, p34 protein kinase, CDC2, CDC28A, CDKN1, P34CDC2, Cyclin-dependent kinase 2, Cell division protein kinase 2 p33 protein kinase, CDK2, CDKN2, Cyclin-dependent kinase 3, Cell division protein kinase 3, CDK3, CDKN3
F2387	Phospho-CDK1/2/3/5 (Tyr15) Antibody [B6L9]
F2496	Phospho-CDK2 (Thr14) Antibody [F10F1]
F3552	Phospho-CDK2 (Thr160) Antibody [N24F24]
A5954	Phospho-Cdk2 (Y15) Rabbit Recombinant mAb	Phospho-Cdk2 (Y15) Rabbit Recombinant mAb detects endogenous levels of phosphorylated Cdk2 (Y15).
F0495	Phospho-Chk1 (Ser317) Antibody [N9E3]
F0242	Phospho-Chk1 (Ser345) Antibody [P19M4]	Chk1 (phospho S345),Phospho-Chk1 (Ser345)
F0243	Phospho-Chk2 (Thr68) Antibody [L12K12]
F0244	Phospho-Cofilin (Ser3) Antibody [G14H6]	Cofilin (phospho S3),Phospho-Cofilin (Ser3)
F2953	Phospho-Cofilin (Ser3) Antibody [G1C13]	Cofilin (phospho S3),Phospho-Cofilin (Ser3)
F1346	Phospho-Connexin 43 (Ser368) Antibody [J12F20]	Connexin 43 / GJA1 (phospho S368),Phospho-Connexin 43 (Ser368)
F1943	Phospho-cPLA2 (Ser505) Antibody [L10N8]	Cytosolic Phospholipase A2 (phospho S505),Phospho-cPLA2 (Ser505)
F0154	Phospho-CREB (Ser133) Antibody [K11M21]	CREB (phospho S133),Phospho-CREB (Ser133)
F2525	Phospho-CREB (Ser133) Antibody [M20D18]	CREB (phospho S133),Phospho-CREB (Ser133)
F4234	Phospho-CrkL (Tyr207) Antibody [B13N10]
F0593	Phospho-Cyclin D1 (Thr286) Antibody [P16A10]
F2175	Phospho-DNA PKcs (Ser2056) Antibody [M17B5]	DNA PKcs (phospho S2056),Phospho-DNA-PKcs (Ser2056)
F0594	Phospho-DRP1 (Ser637) Antibody [J22A19]	DRP1 (phospho S637),Phospho-DRP1 (Ser637)
F1394	Phospho-EGF Receptor (Thr669) Antibody [H18D23]
F0298	Phospho-EGF Receptor (Tyr1068) Antibody [J6N1]	EGFR (phospho Y1068),Phospho-EGF Receptor (Tyr1068)
F4089	Phospho-EGF Receptor (Tyr1173) Antibody [E8J4]
F0749	Phospho-EGF Receptor (Tyr845) Antibody [K14C19]
F2845	Phospho-EGFR (Tyr1068) Antibody [F6A14]	EGFR (phospho Y1068),Phospho-EGF Receptor (Tyr1068)
F0257	Phospho-eIF2α (Ser51) Antibody [F15N7]	EIF2S1 (phospho S51),Phospho-eIF2α (Ser51)
F1305	Phospho-eIF4B (Ser406) Antibody [B22D6]
F1674	Phospho-eIF4E (Ser209) Antibody [N23E19]	eIF4E (phospho S209),Phospho-eIF4E (Ser209)
F0354	Phospho-eNOS (Ser1177) Antibody [N17K15]	eNOS (phospho S1177),eNOS (pS1177),Phospho-eNOS (Ser1177)
F0595	Phospho-EphA2 (Ser897) Antibody [G4G3]
F0852	Phospho-EphA2 (Tyr588) Antibody [F13K2]
F3624	Phospho-ErbB2/ErbB4 (Y1248/1284) Antibody [K1P9]
F3606	Phospho-ErbB2/HER2 (Tyr877) Antibody [K16P14]	ErbB2 / HER2 (phospho Y877),Phospho-HER2/ErbB2 (Tyr877)
F1555	Phospho-Erk1 (T 202/Y 204)/Erk2 (T 185/Y 187) Antibody [G4M7]	ERK1 (phospho T202 + Y204) + ERK2 (phospho T185 + Y187),Erk1 (pT202/pY204) + Erk2 (pT185/pY187),MAP Kinase, Activated (Diphosphorylated ERK-1&2),phospho-Erk1/2 (Thr202/Tyr204, Thr185/Tyr187)
F0502	Phospho-Erk1 (Tyr204)/Erk2 (Tyr187) Antibody [H17M24]	Mitogen-activated protein kinase 3, ERT2, Extracellular signal-regulated kinase 1, ERK-1, ERK1, Insulin-stimulated MAP2 kinase, MAP kinase isoform p44, p44-MAPK, Microtubule-associated protein 2 kinase, p44-ERK1, MAPK3, PRKM3, Mitogen-activated protein kinase 1, MAP kinase 1, MAPK 1, ERT1, Extracellular signal-regulated kinase 2, ERK-2, MAP kinase isoform p42, p42-MAPK, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2, ERK2, PRKM1, PRKM2
F3945	Phospho-ERK1/ERK2 (T185/Y187) Antibody [G10H2]
F1716	Phospho-ERK1/ERK2 (T202/185) Antibody [G2D16]
F3358	Phospho-Estrogen Receptor α (Ser118) Antibody [L4E1]	Estrogen Receptor alpha (phospho S118),Phospho-Estrogen Receptor α (Ser118)
F2876	Phospho-FAK (Tyr397) Antibody [G24K11]	FAK (phospho Y397),FAK (Tyr397),p-FAK,Phospho-FAK (Tyr397)
F2747	Phospho-FGFR3 (Tyr724) Antibody [K24F17]
F1462	Phospho-FLT3 (Tyr589/591) Antibody [K5L11]
F0800	Phospho-FoxO1 (Ser256) Antibody [E12L24]	FOXO1A (phospho S256),Phospho-FoxO1 (Ser256)
F1155	Phospho-FoxO3A (Ser253) Antibody [C5A15]	FOXO3A (phospho S253),Phospho-FoxO3a (Ser253)
F0902	Phospho-FoxO3a (Ser413) Antibody [A11H11]
F0799	Phospho-FRA1 (Ser265) Antibody [N10P17]
F3694	Phospho-Glucose Transporter GLUT4 (Ser488) Antibody [A20E7]
F2661	Phospho-Glycogen Synthase (Ser 641) Antibody [D7F20]
F2962	Phospho-Glycogen Synthase 1 (Ser641) Antibody [E2C19]
F0464	Phospho-GSK-3 (Ser21) Antibody [M22B5]	GSK3 alpha (phospho S21),Phospho-GSK-3α (Ser21)
F0497	Phospho-GSK-3α/β (Ser21/9) Antibody [M19M24]	Glycogen synthase kinase-3 alpha, GSK-3 alpha, Glycogen synthase kinase-3 beta, GSK-3α, GSK-3 beta, GSK-3β, GSK3A, GSK3B, GSK3, Serine/threonine-protein kinase GSK3B
F0299	Phospho-GSK-3β (Ser9) Antibody [G1H24]	GSK3B (phospho S9),p-GSK3 beta,Phospho-GSK-3-beta (Ser9),Phospho-GSK-3β (Ser9)
F4124	Phospho-GSK-3β (Ser9) Antibody [G6H5]
A5960	Phospho-GSK3 (alpha+beta)(Y216+Y279) Rabbit Recombinant mAb	Phospho-GSK3 (alpha+beta)(Y216+Y279) Rabbit Recombinant mAb detects endogenous levels of phosphorylated GSK3 (alpha+beta)(Y216+Y279).
F3397	Phospho-HDAC4/5/7 (Ser246/259/155) Antibody [J21N6]
F0853	Phospho-HER2/ErbB2 (Tyr1196) Antibody [L1F9]
F0245	Phospho-HER2/ErbB2 (Tyr1221/1222) Antibody [P19C10]	ErbB2 / HER2 (phospho Y1221 + Y1222),Phospho-HER2/ErbB2 (Tyr1221/1222)
A5632	Phospho-Histone H1.4 (T17) Rabbit Recombinant mAb	Phospho-Histone H1.4 (T17) Rabbit Recombinant mAb detects endogenous level of total Phospho-Histone H1.4 (T17).
F1482	Phospho-Histone H2B (Ser14) Antibody [B13A9]
F0246	Phospho-Histone H3 (Ser10) Antibody [C5J11]	Histone H3 (phospho S10),Phospho-Histone H3 (Ser10)
F2868	Phospho-Histone H3 (Ser10) Antibody [F5P3]	Histone H3 (phospho S10),Phospho-Histone H3 (Ser10)
F2229	Phospho-Histone H3 (Ser10/ Thr11) Antibody [D13P19]
F4158	Phospho-Histone H3 (Thr3) Antibody [C4K12]
F2502	Phospho-Histone H3.3 (Ser31) Antibody [C20A16]
A5260	Phospho-HSF1(S326) Rabbit Recombinant mAb	Phospho-HSF1(S326) Rabbit Recombinant mAb detects endogenous level of total phospho-HSF1(S326).
F3688	Phospho-Hsp27 (Ser15) Antibody [D1B2]	Hsp27 (phospho S15),Phospho-HSP27 (Ser15)
F0750	Phospho-HSP27 (Ser82) Antibody [J19L2]	Hsp27 (phospho S82),Phospho-HSP27 (Ser82),Phospho-HSP27 (Ser82) II
F3764	Phospho-Hsp27 (Ser82) Antibody [M1P19]	Hsp27 (phospho S82),Phospho-HSP27 (Ser82),Phospho-HSP27 (Ser82) II
F0247	Phospho-IGF-1R (Y1135/1136)/IR (Y1150/1151) Antibody [B2J21]	Insulin-like growth factor 1 receptor, CD221, IGF1R, Insulin receptor, CD220, IR
F0398	Phospho-IGF-1R β (Tyr1135) Antibody [F22C20]
F1451	Phospho-IGF-1R β (Tyr980) Antibody [K22N4]
F3033	Phospho-IGF-1R β (Y1131)/IR β (Y1146) Antibody [J6K20]	Phospho-IGF-I Receptor β (Tyr1131)/Insulin Receptor β (Tyr1146),Phospho-IGF-I Receptor β(Tyr1131)/Insulin Receptor β (Tyr1146)
A5983	Phospho-IKB alpha (S32) Rabbit Recombinant mAb	Phospho-IKB alpha (S32) Rabbit Recombinant mAb detects endogenous levels of total Phospho-IKB alpha (S32).
F2237	Phospho-IKB α (Ser36) Antibody [B13N13]
F0448	Phospho-IKKα/β (S176/177) Antibody [L19G16]
F3837	Phospho-Insulin Receptor (Tyr1185) Antibody [D6L11]
F1383	Phospho-IP3 Receptor (Ser1756) Antibody [E15A22]
F4013	Phospho-IRF3 (Ser386) Antibody [L20H23]
F1489	Phospho-IRS-1 (Ser302) Antibody [K1C11]
F1370	Phospho-IRS-1 (Ser318) Antibody [C11A11]
F0197	Phospho-IκBα (Ser32/36) Antibody [F24N7]	IkB-alpha [p Ser32, p Ser36],Phospho-IκBα (Ser32/36)
F2644	Phospho-JAK1 (Tyr1034/1035)/JAK2 (Tyr1007/1008) Antibody [L3G19]
F3912	Phospho-JNK (Thr183) Antibody [D9B9]
F1572	Phospho-JNK1/2/3 (T183/183/221) Antibody [D17M9]
F1573	Phospho-JNK1/2/3 (Tyr185/185/223) Antibody [G4D15]
F3444	Phospho-KAP1 (Ser824) Antibody [M4J16]	KAP1 (phospho S824),KAP1 [p Ser824],Phospho-KAP-1 (Ser824)
F1962	Phospho-Lamin A/C (Ser22) Antibody [D12F9]
F3064	Phospho-LAT (Tyr220) Antibody [L15N18]
A5170	Phospho-LAT (Y191) Rabbit Recombinant mAb	Phospho-LAT (Y191) Rabbit Recombinant mAb detects endogenous level of total Phospho-LAT (Y191).
F3598	Phospho-LAT(Tyr200) Antibody [B1B14]
F0344	Phospho-LATS1 (Thr1079) Antibody [F2E16]
F1549	Phospho-LRRK2 (Ser935) Antibody [K11C19]
F3330	Phospho-LRRK2 (Ser955) Antibody [F1M24]
F3144	Phospho-Lyn (Tyr507) Antibody [E9D13]	Lyn (phospho Y507),Phospho-Lyn (Tyr507)
F2837	Phospho-MARCKS (Ser158) Antibody [D19L10]
F1259	Phospho-MARCKS (Ser167/170) Antibody [A4H10]
F2984	Phospho-MCM2 (Ser40) Antibody [M14L21]
F3206	Phospho-MCM2 (Ser53) Antibody [N19A7]
F1094	Phospho-MEK1 (Ser298) Antibody [D18F23]	MEK1 (phospho S298),Phospho-MEK1 (Ser298)
F0345	Phospho-MEK1/2 (Ser217/221) Antibody [G6P21]	Dual specificity mitogen-activated protein kinase kinase 2, MAP kinase kinase 2, MAPKK 2, ERK activator kinase 2, MAPK/ERK kinase 2, MAP2K2, MKK2, PRKMK2, Dual specificity mitogen-activated protein kinase kinase 1, MAP kinase kinase 1, MAPKK 1, MKK1, ERK activator kinase 1 MAPK/ERK kinase 1, MAP2K1, PRKMK1
F1377	Phospho-Met (Tyr1003) Antibody [A3E17]
F1043	Phospho-Met/c-Met (Tyr1349 ) Antibody [F18B11]	Met (c-Met) (phospho Y1349),Phospho-Met (Tyr1349)
F0704	Phospho-MKK3/6 (S189/207) Antibody [G15K24]	Dual specificity mitogen-activated protein kinase kinase 3, MAP kinase kinase 3, MAPKK 3, MEK 3, Stress-activated protein kinase kinase 2, SAPK kinase 2, SAPKK-2, SAPKK2, MAP2K3, PRKMK3, SKK2, MAP kinase kinase 6, MAPKK 6, MEK 6, SAPK kinase 3, SAPKK-3, SAPKK3, MAP2K6, PRKMK6, SKK3, Dual specificity mitogen-activated protein kinase kinase 6, Stress-activated protein kinase kinase 3
F3845	Phospho-Moesin (Thr558) Antibody [N2L9]
A5328	Phospho-MSK1 (S376) Rabbit Recombinant mAb	Phospho-MSK1 (S376) Rabbit Recombinant mAb detects endogenous level of total phospho-MSK1 (S376).
F0855	Phospho-MST1/2 (Thr183/180) Antibody [K6K3]	MST1/MST2 (phospho T180 + T183),Phospho-MST1 (Thr183)/MST2 (Thr180)
F2584	Phospho-mTOR (Ser2448) Antibody [P18P17]	mTOR (phospho S2448),Phospho-mTOR (Ser2448),p-mTOR
F1242	Phospho-Myosin Light Chain 2 (Thr18/Ser19) Antibody [C13P19]
F0450	Phospho-NDRG1 (Thr346) Antibody [B22E4]
F3665	Phospho-NEDD4-2 (Ser448) Antibody [D21H23]	NEDD4-2 (phospho S448),Phospho-NEDD4L (Ser448)
F0400	Phospho-NF-κB p105 (Ser932) Antibody [H7P1]
F3499	Phospho-NF-κB p65 (Ser468) Antibody [G12A6]
F3512	Phospho-NF-κB p65 (Ser536) Antibody [G11D5]	NF-kB p65 (phospho S536),Phospho-NFkB p65 (Ser536),Phospho-NF-κB p65 (Ser536),p-RELA/NFκB p65
F0155	Phospho-NF-κB p65 (Ser536) Antibody [M4C8]	NF-kB p65 (phospho S536),Phospho-NFkB p65 (Ser536),Phospho-NF-κB p65 (Ser536),p-RELA/NFκB p65
F2394	Phospho-NMDAR2B (Ser1303) Antibody [G14F14]
F1552	Phospho-Nrf2 (Ser40) Antibody [N4G2]
F1167	Phospho-p27 KIP 1 (Ser10) Antibody [D8F10]	Phospho-p27 KIP 1 (Ser 10) Rabbit mAb detects endogenous levels of p27 KIP 1 only when phosphorylated at Ser10.
F4107	Phospho-p38 MAPK (Tyr182) Antibody [H7F4]
F0007	Phospho-p44/42 MAPK (Erk1/2) (T202/Y204) Antibody [D13L13]	Mitogen-activated protein kinase 3, ERT2, Extracellular signal-regulated kinase 1, ERK-1, ERK1, Insulin-stimulated MAP2 kinase, MAP kinase isoform p44, p44-MAPK, Microtubule-associated protein 2 kinase, p44-ERK1, MAPK3, PRKM3, Mitogen-activated protein kinase 1, MAP kinase 1, MAPK 1, ERT1, Extracellular signal-regulated kinase 2, ERK-2, MAP kinase isoform p42, p42-MAPK, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2, ERK2, PRKM1, PRKM2
F0355	Phospho-p53 (Ser15) Antibody [K22F18]	p53 (phospho S15),Phospho-p53 (Ser15)
F2377	Phospho-p53 (Ser20) Antibody [J22P21]	p53 (phospho S20),Phospho-p53 (Ser20)
F2366	Phospho-p53 (Ser37) Antibody [P9G5]	p53 (phospho S37),Phospho-p53 (Ser37),TP53 (phospho S37)
F2931	Phospho-p53 (Ser392) Antibody [E21F8]	p53 (phospho S392),Phospho-p53 (Ser392)
F3927	Phospho-p53 (Ser9) Antibody [G23F10]
F2907	Phospho-P70 S6 Kinase β/SRK (Ser371) Antibody [A17F8]	P70 S6 Kinase beta/SRK (phospho S371)
F2333	Phospho-p70 S6K (Thr421/Ser424) Antibody [E5J12]	p70 S6K phospho Thr421 Ser424,Phospho-p70 S6 Kinase (Thr421/Ser424)
F0557	Phospho-p90 RSK (Thr359) Antibody [M10J19]	Phospho-p90RSK (Thr359),RSK1 p90 (phospho T359)
F0503	Phospho-p90RSK (Ser380) Antibody [F5E5]	Ribosomal protein S6 kinase alpha-3, S6K-alpha-3, S6K-α-3, 90 kDa ribosomal protein S6 kinase 3, p90-RSK 3, p90RSK3, Insulin-stimulated protein kinase 1 , ISPK-1, MAP kinase-activated protein kinase 1b, MAPK-activated protein kinase 1b, MAPKAP kinase 1b, MAPKAPK-1b, Ribosomal S6 kinase 2, RSK-2, p90RSK2, RPS6KA3, ISPK1, MAPKAPK1B, RSK2, Ribosomal protein S6 kinase alpha-2, S6K-alpha-2, S6K-α-2, 90 kDa ribosomal protein S6 kinase 2, p90-RSK 2, p90RSK2, MAP kinase-activated protein kinase 1c, MAPK-activated protein kinase 1c, MAPKAP kinase 1c, MAPKAPK-1c, Ribosomal S6 kinase 3, RSK-3, RPS6KA2, MAPKAPK1C, RSK3, S6K-alpha-1, p90-RSK 1, p90RSK1, p90S6K, MAPKAP kinase 1a, MAPKAPK-1a, RSK-1, RPS6KA1, MAPKAPK1A, RSK1, Ribosomal S6 kinase 1
A5245	Phospho-p95/NBS1 (S343) Rabbit Recombinant mAb	Phospho-p95/NBS1 (S343) Rabbit Recombinant mAb detects endogenous level of total Phospho-p95/NBS1 (S343).
F2117	Phospho-PAK1/2/3 (Ser144/141/154) Antibody [A5J4]
A5262	Phospho-PAK1/2/3(S144/S141/S139) Rabbit Recombinant mAb	Phospho-PAK1/2/3(S144/S141/S139) Rabbit Recombinant mAb detects endogenous level of total Phospho-PAK1/2/3(S144/S141/S139).
F0804	Phospho-PDGF Receptor β (Tyr1009) Antibody [G5H10]
F1260	Phospho-PDGF Receptor β (Tyr1021) Antibody [M20P20]
F1500	Phospho-PDGF Receptor β (Tyr740) Antibody [M18D12]
F1497	Phospho-PDGF Receptor β (Tyr771) Antibody [C22C4]
F1658	Phospho-PDHA1 (Ser293) Antibody [L15N22]	PDHA1 (phospho S293),Phospho-Pyruvate Dehydrogenase α1 (Ser293),Pyruvate Dehydrogenase E1-alpha subunit [p Ser293]
F0401	Phospho-PDK1 (Ser241) Antibody [K13M24]
F3893	Phospho-PERK (Thr982) Antibody [A3P5]
F0903	Phospho-PFKFB2 (Ser483) Antibody [A5G21]
F4613	Phospho-PKA C (Thr197) Antibody [L13C4]
A5601	Phospho-PKA R2 (S99) Rabbit Recombinant mAb	Phospho-PKA R2 (S99) Rabbit Recombinant mAb detects endogenous level of total Phospho-PKA R2 (S99).
F1206	Phospho-PKA α/β/γ (catalytic subunit) (T197) Antibody [F5K1]	Phospho-PKA C (Thr197),PKA alpha/beta/gamma (catalytic subunit) (phospho T197)
F2119	Phospho-PKAR2/PKR2 (Ser99) Antibody [F21N14]
F3551	Phospho-PKC (pan) (βII Ser660) Antibody [G6B3]
F0651	Phospho-PKC (pan) (ζ Thr410) Antibody [F2F5]	Protein kinase C beta type, Protein kinase C alpha type, Protein kinase C zeta type, Protein kinase C eta type, Protein kinase C delta type, Protein kinase C theta type, Protein kinase C epsilon type, Protein kinase C gamma type, Protein kinase C iota type, PKC-B, PKC-beta, PKC β, PRKCB, PKCB, PRKCB1, PKC-A, PKC-alpha, PKC α, PRKCA, PKCA, PRKACA, nPKC-zeta, PRKCZ, PKC2, PKC ζ, PKC η, PKC-L, nPKC-eta, PRKCH, PKCL, PRKCL, PKC δ, nPKC-delta, PRKCD, PKCD, PKC θ, nPKC-theta, PRKCQ, PRKCT, PKC ε, nPKC-epsilon, PRKCE, PKCE, PKC-gamma, PKC γ, PRKCG, PKCG, PKC ι, nPKC-iota, PRKCI, DXS1179E, Atypical protein kinase C-lambda/iota, PRKC-lambda/iota, aPKC-lambda/iota, Tyrosine-protein kinase PRKCD, Sphingosine-dependent protein kinase-1
F2745	Phospho-PKC (Ser660) Antibody [J16E1]
F2615	Phospho-PKC (Thr514) Antibody [B16L4]
F2482	Phospho-PKC α (Ser657) Antibody [M1L12]
F2561	Phospho-PKC α (Thr497) Antibody [A17J8]
F2914	Phospho-PKC α (Thr638) Antibody [E6G7]
F3958	Phospho-PKC δ (Tyr311) Antibody [P4C22]
F2335	Phospho-PKCθ/PRKCQ (Thr538) Antibody [D2M12]	Phospho-PKCθ (Thr538),PKC theta/PRKCQ (phospho T538)
F1597	Phospho-PKR (Thr446) Antibody [K16N13]
F2372	Phospho-PKR (Thr451) Antibody [C9J9]
F0705	Phospho-PLCγ1 (Ser1248) Antibody [E9E19]
F0752	Phospho-PLCγ1 (Tyr783) Antibody [C6N17]	Phospholipase C gamma 1/PLC-gamma-1 (phospho Y783),Phospho-PLCγ1 (Tyr783)
A5962	Phospho-POLR2A (S2) Rabbit Recombinant mAb	Phospho-POLR2A (S2) Rabbit Recombinant mAb detects endogenous levels of phosphorylated POLR2A (S2).
A5943	Phospho-PP2A (Y307) Rabbit Recombinant mAb	Phospho-PP2A (Y307) Rabbit Recombinant mAb detects endogenous levels of phosphorylated PP2A (Y307).
F2595	Phospho-PPP1A/PPP1CA (Thr320) Antibody [J22F13]	Phospho-PP1α (Thr320),PPP1A/PPP1CA (phospho T320)
F4154	Phospho-PRAS40 (Thr246) Antibody [P11G2]
F0252	Phospho-PRAS40 (Thr246) Antibody [P21B22]
F0499	Phospho-PTEN (Ser380/Thr382/383) Antibody [K19C17]	Phospho-PTEN (Ser380),Phospho-PTEN (Ser380/Thr382/383),PTEN (phospho S380)
F2618	Phospho-PTEN (Thr366) Antibody [A11K14]
F1636	Phospho-RAB10 (Thr73) Antibody [M19N14]
A5958	Phospho-Raf1 (S621) Rabbit Recombinant mAb	Phospho-Raf1 (S621) Rabbit Recombinant mAb detects endogenous levels of phosphorylated Raf1 (S621).
F1517	Phospho-Rb (Ser608) Antibody [A17K22]	Phospho-Rb (Ser608),Rb (phospho S608)
F3348	Phospho-Rb (Ser780) Antibody [C10L19]
F0501	Phospho-Rb (Ser780) Antibody [L13P18]	Phospho-Rb (Ser780),Progesterone Receptor,Rb (phospho S780)
F0302	Phospho-Rb (Ser807/811) Antibody [P5B14]
F3609	Phospho-Rb (Thr373) Antibody [F9H20]
F3424	Phospho-Rb (Thr826) Antibody [F21F15]
F0533	Phospho-Rictor (Thr1135) Antibody [P16B3]
F0500	Phospho-RIP (Ser166) Antibody [C18P2]
F2949	Phospho-RNA Pol II CTD (Ser5) Antibody [E1J24]	Phospho-Rpb1 CTD (Ser5),RNA polymerase II CTD repeat YSPTSPS (phospho S5),RNA polymerase II subunit B1 (phospho-CTD Ser 5)
F0023	Phospho-RNA pol II CTD (Ser5) Antibody [F13E6]	Phospho-Rpb1 CTD (Ser5),RNA polymerase II CTD repeat YSPTSPS (phospho S5),RNA polymerase II subunit B1 (phospho-CTD Ser 5)
F3793	Phospho-RNA Pol II CTD repeat YSPTSPS (S2) Antibody [C9K19]	Phospho-Rpb1 CTD (Ser2),RNA polymerase II CTD repeat YSPTSPS (phospho S2),RNA polymerase II subunit B1 (phospho CTD Ser-2)
A5329	Phospho-RPA2 (T21) Rabbit Recombinant mAb	Phospho-RPA2 (T21) Rabbit Recombinant mAb detects endogenous level of total phospho-RPA2 (T21).
F2375	Phospho-RPA32/RPA2 (Thr21) Antibody [H20D7]
F0805	Phospho-Rpb1 CTD (Ser2) Antibody [L19G24]	Phospho-Rpb1 CTD (Ser2),RNA polymerase II CTD repeat YSPTSPS (phospho S2),RNA polymerase II subunit B1 (phospho CTD Ser-2)
F1261	Phospho-Rpb1 CTD (Ser7) Antibody [C17G21]	Phospho-Rpb1 CTD (Ser7),RNA polymerase II subunit B1 (phospho-CTD Ser 7)
F2728	Phospho-RSK1 p90 (Ser380) Antibody [G13M8]
F2334	Phospho-RSK1 p90 (T359/S363) Antibody [P19K15]	Phospho-p90RSK (Thr359/Ser363),RSK1 p90 (phospho T359 + S363)
F4044	Phospho-RSK1 p90 (Thr359) Antibody [L24F14]
F0904	Phospho-RSK2 (Ser227) Antibody [F3D15]	S6K-alpha-3, S6K-α-3, p90-RSK 3; p90RSK3, ISPK-1, MAPKAP kinase 1b, MAPKAPK-1b, RSK-2, p90RSK2, RPS6KA3, ISPK1, MAPKAPK1B, RSK2
F0198	Phospho-S6 Ribosomal Protein (S235/236) Antibody [G7G11]	Phospho-S6 Ribosomal Protein (Ser235/236),RPS6 (phospho S235 + S236)
F3530	Phospho-S6 Ribosomal Protein (S235/236) Antibody [H18E15]	Phospho-S6 Ribosomal Protein (Ser235/236),RPS6 (phospho S235 + S236)
F0303	Phospho-S6 Ribosomal Protein (Ser240/244) Antibody [H21K17]	Phospho-S6 Ribosomal Protein (Ser240/244),RPS6 (phospho S240 + S244)
A5033	Phospho-S6K1(T421/S424) Rabbit Recombinant mAb	Phospho-S6K1(T421/S424) Rabbit Recombinant mAb detects endogenous levels of Phospho-S6K1(T421/S424).
F1484	Phospho-SAMHD1 (Thr592) Antibody [K24L13]
F0600	Phospho-SEK1/MKK4 (Ser257) Antibody [C11A7]
F1300	Phospho-SGK1 (Ser78) Antibody [E23F7]
F0706	Phospho-SHP-1 (Tyr564) Antibody [N2F10]
F1301	Phospho-SHP-2 (Tyr580) Antibody [M15P16]
A5278	Phospho-SHP2 (Y542) Rabbit Recombinant mAb	Phospho-SHP2 (Y542) Rabbit Recombinant mAb detects endogenous level of total Phospho-SHP2 (Y542).
F3052	Phospho-SLP-76 (Ser376) Antibody [K18E5]
F2633	Phospho-Smad1 (Ser206) Antibody [D10B24]
F0348	Phospho-Smad1/5 (Ser463/465) Antibody [H6D11]
F0347	Phospho-Smad1/5/9 (S463/465, S463/465, S465/467) Antibody [L11J17]	Phospho-Smad1 (Ser463/465)/ Smad5 (Ser463/465)/ Smad9 (Ser465/467),SMAD1 + SMAD5 + SMAD9 (phospho S463 + S465 + S467)
F2875	Phospho-Smad1/5/9 (S463/465/467) Antibody [K12G16]	Phospho-Smad1 (Ser463/465)/ Smad5 (Ser463/465)/ Smad9 (Ser465/467),SMAD1 + SMAD5 + SMAD9 (phospho S463 + S465 + S467)
F3553	Phospho-SMAD2 (Ser245/250/255) Antibody [H4M3]
F1689	Phospho-Smad2 (Ser255) Antibody [H13B7]
F3740	Phospho-Smad2 (Ser467) Antibody [P3A22]
F2846	Phospho-Smad3 (Ser423/Ser425) Antibody [L3N2]	Phospho-Smad3 (Ser423/425),Smad3 (phospho S423 + S425), Smad5 (463/465), Smad1 (Ser 463/465), Smad2 (Ser 465/467)d5 (Se
F1378	Phospho-SMC1 (Ser957) Antibody [L22G18]
F1460	Phospho-SQSTM1/p62 (Ser349) Antibody [C5L4]	Phospho-SQSTM1/p62 (Ser349),SQSTM1 / p62 (phospho S349)
F0955	Phospho-SQSTM1/p62 (Ser403) Antibody [B10J4]
F0906	Phospho-Src (Ser17) Antibody [A23D16]
F2912	Phospho-Src (Tyr529) Antibody [D13P6]
F0304	Phospho-Src Family (Tyr416) Antibody [H4N15]	Tyrosine-protein kinase Yes, Proto-oncogene c-Yes, p61-Yes, YES1, YES, Tyrosine-protein kinase Lyn, Lck/Yes-related novel protein tyrosine kinase, V-yes-1 Yamaguchi sarcoma viral related oncogene homolog, p53Lyn, p56Lyn, LYN, JTK8, Tyrosine-protein kinase Lck, LSK, Lymphocyte cell-specific protein-tyrosine kinase, Protein YT16, Proto-oncogene Lck, T cell-specific protein-tyrosine kinase, p56-LCK, Tyrosine-protein kinase HCK, Hematopoietic cell kinase, Hemopoietic cell kinase, p59-HCK/p60-HCK, p59Hck, p61Hck, Proto-oncogene tyrosine-protein kinase Src, Proto-oncogene c-Src, p60-Src, SRC, SRC1, Tyrosine-protein kinase Fyn, Proto-oncogene Syn, Proto-oncogene c-Fyn, SLK, p59-Fyn
F1649	Phospho-SRC Family (Tyr418) Antibody [H7L14]
F3253	Phospho-STAT1 (Ser727) Antibody [C14E15]	Phospho-Stat1 (Ser727),STAT1 (phospho S727)
F0199	Phospho-STAT1 (Tyr701) Antibody [N19D1]	Phospho-Stat1 (Tyr701),p-Stat1,STAT1 (phospho Y701)
F0554	Phospho-STAT2 (Tyr690) Antibody [G1A15]	Phospho-Stat2 (Tyr690),STAT2 (phospho Y690)
F1212	Phospho-STAT3 (Ser727) Antibody [B8F21]	Phospho-Stat3 (Ser727),STAT3 (phospho S727)
F0157	Phospho-STAT3 (Tyr705) Antibody [B17F7]	Phospho-Stat3 (Tyr705),p-Stat3,STAT3 (phospho Y705)
A5948	Phospho-Stat5 (Y694) Rabbit Recombinant mAb	Phospho-Stat5 (Y694) Rabbit Recombinant mAb detects endogenous levels of phosphorylated Stat5 (Y694).
F0555	Phospho-STAT6 (Tyr641) Antibody [A16N6]	Phospho-Stat6 (Tyr641),STAT6 (phospho Y641)
F4042	Phospho-STAT6 (Tyr641) Antibody [G7E12]
F1396	Phospho-Stathmin (Ser38) Antibody [L1J22]
F1303	Phospho-Synapsin-1 (Ser605) Antibody [M6M7]
F2614	Phospho-Tau (Ser199) Antibody [F2N9]	Phospho-Tau (Ser199),Tau (phospho S199)
F4113	Phospho-Tau (Ser202) Antibody [L24P20]
F0059	Phospho-Tau (Ser202/ Thr205) Antibody [C18J10]	Phospho-Tau (Ser202, Thr205),Phospho-Tau (Ser202/Thr205),Tau (phospho S202 + T205)
F3533	Phospho-Tau (Ser202/Thr205) Antibody [M2L8]	Phospho-Tau (Ser202, Thr205),Phospho-Tau (Ser202/Thr205),Tau (phospho S202 + T205)
F1117	Phospho-Tau (Ser396) Antibody [E23L9]	Phospho-Tau (Ser396),Tau (phospho S396)
F3592	Phospho-Tau (Ser396) Antibody [F10A13]	Phospho-Tau (Ser396),Tau (phospho S396)
F2593	Phospho-Tau (Ser404) Antibody [F11H2]	Phospho-Tau (Ser404),Tau (phospho S404)
F3020	Phospho-Tau (Ser416) Antibody [H22B7]	Phospho-Tau (Ser416),Tau (phospho S416)
F2389	Phospho-Tau (Thr231) Antibody [G20J9]	Phospho-Tau (Thr231),Tau (phospho T231)
F0255	Phospho-TBK1/NAK (Ser172) Antibody [H16A23]	NAK/TBK1 (phospho S172),Phospho-TBK1/NAK (Ser172)
F1474	Phospho-TFEB (Ser211) Antibody [N21G19]
F1348	Phospho-TRAF2 (Ser11) Antibody [L10C17]
F1948	Phospho-Tuberin/TSC2 (Ser1387) Antibody [B6D9]
F0956	Phospho-Tyk2 (Tyr1054/1055) Antibody [H3E15]
F1476	Phospho-Ubiquitin (Ser65) Antibody [C22F3]
F0305	Phospho-ULK1 (Ser555) Antibody [N1G15]	Phospho-ULK1 (Ser555),ULK1 (phospho S555)
F0351	Phospho-ULK1 (Ser757) Antibody [A12P8]
F1397	Phospho-VASP (Ser157) Antibody [G6G22]	Phospho-VASP (Ser157),VASP (phospho S157)
F2659	Phospho-VASP (Ser239) Antibody [N1M20]
F4139	Phospho-VEGF Receptor 2 (Tyr1175) Antibody [M10N15]
F0256	Phospho-VEGF Receptor 2 (Tyr1175) Antibody [M9C2]	Phospho-VEGF Receptor 2 (Tyr1175),VEGF Receptor 2 (phospho Y1175)
F3649	Phospho-Vimentin (Ser39) Antibody [B14E20]
F0602	Phospho-Wee1 (Ser642) Antibody [P3A10]
F0352	Phospho-YAP (Ser127) Antibody [K8E8]	Phospho-YAP (Ser127),YAP1 (phospho S127)
F0753	Phospho-YAP (Ser397) Antibody [B23M8]
F0603	Phospho-YB1 (Ser102) Antibody [D17A16]
F0556	Phospho-Zap-70 (Tyr319)/Syk (Tyr352) Antibody [L15L21]	Tyrosine-protein kinase ZAP-70, 70 kDa zeta-chain associated protein, Syk-related tyrosine kinase, ZAP70, SRK, Tyrosine-protein kinase SYK, Spleen tyrosine kinase, p72-Syk, SYK
F1478	Phospho-Zyxin (Ser142/143) Antibody [L24L6]
F2121	Phospho-β Arrestin 1 (Ser412) Antibody [B21D5]
F0908	Phospho-β-Arrestin 1 (Ser412) Antibody [C17A12]
F0494	Phospho-β-Catenin (Ser552) Antibody [K9A16]
F0297	Phospho-β-Catenin (Ser675) Antibody [G12L16]
S3349	Phosphocholine chloride calcium salt tetrahydrate	Phosphocholine (Phosphorylcholine) chloride calcium salt tetrahydrate is an active endogenous metabolite.
F1349	Phospholamban Antibody [C9L22]
E7310	Phosphomycin calcium	Phosphomycin calcium (MK-0955) calcium is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin calcium shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria.
S3356	Phosphonoacetic acid	Phosphonoacetic acid (PAA) is an active endogenous metabolite that possesses a restricted potential to block DNA biosynthesis. Phosphonoacetic acid exhibits anti-viral activities.
S7382	Phosphoramidon Disodium Salt	Phosphoramidon Disodium Salt is a metalloendopeptidase inhibitor, widely used as a biochemical tool. Phosphoramidon inhibited ECE, NEP, and ACE activities with IC50 values of 3.5 μM, 0.034 μM, and 78 μM, respectively.
E7023	Phosphorylcholine chloride	Phosphorylcholine chloride (Phosphocholine chloride) is a zwitterionic small molecule that forms the hydrophilic head group of major eukaryotic membrane phospholipids and is also found on the surface of commensal or pathogenic bacteria associated with eukaryotes. It exhibits immunomodulatory properties and commonly used in biomaterial coatings to reduce protein adsorption, prevent unwanted cell adhesion, and improve implant biocompatibility.
F2798	PHOX2B C-terminal Antibody [C18L18]
S9913	PHPS1	PHPS1 (PTP Inhibitor V), a potent and cell-permeable inhibitor, is specific for Shp2 with Ki value of 0.73 μM.
E3701	Phryma Leptostachya L. var. asiatica Hara Extract	Phryma Leptostachya L. Var. Asiatica Hara Extract is derived from Phryma leptostachya L. subsp. asiatica (Hara) Kitamura.
S1556	PHT-427	PHT-427 (CS-0223) is a dual Akt and PDPK1 inhibitor (high affinity binding for the PH domains of Akt and PDPK1) with K_i of 2.7 μM and 5.2 μM, respectively.
S6215	Phthalic acid	Phthalic acid (1,2-Benzenedioic acid) is an aromatic dicarboxylic acid. It is a human xenobiotic metabolite.
S5700	Phthalylsulfathiazole	Phthalylsulfathiazole (Sulfathalidine) is a broad-spectrum antimicrobial that can treat different types of infections including intestinal.
E2693	Phycocyanobilin (PCB)	Phycocyanobilin (PCB) is an open-chain tetrapyrrole chromophore covalently bonded to both polypeptide chains of C-Phycocyanin (C-PC), the most represented biliprotein of Spirulina platensis, the mechanisms by which it protected cells included the reduction of oxidative stress damage, which could contribute to its clinical efficacy for the treatment of neurodegenerative diseases. This product has poor solubility, animal experiments are available, cell experiments please choose carefully!
E3838	Phyllanthus Emblica Extract	Phyllanthus Emblica Extract is extracted from Phyllanthus emblica, which has antidiabetic, hypolipidemic, antibacterial, antioxidant, antiulcerogenic, hepatoprotective, gastroprotective, and chemopreventive properties.
E3814	Phyllanthus Urinaria Extract	Phyllanthus Urinaria Extract is extracted from Phyllanthus urinaria (L.), which is used to treat jaundice, diabetes, malaria, and liver diseases.
E3364	Physalis Alkekengi Extract	Physalis Alkekengi Extract is extracted from Physalis alkekengi, which has effects on hyperglycemia by inhibition of oxidative stress, inflammation, and apoptosis, making it a good adjuvant option in diabetes.
S3793	Phytic acid	Phytic acid (Inositol polyphosphate, Inositol hexakisphosphate) is the principal storage form of phosphorus in many plant tissues, especially bran and seeds. It can act as a cofactor in DNA repair by nonhomologous end-joining. Phytic acid inhibits the enzymatic superoxide source xanthine oxidase (XO), and has antioxidative, neuroprotective, anti-inflammatory effects.
S3326	Phytic acid dipotassium salt	Phytic acid dipotassium salt (Phytic acid potassium, IP6 (PS)), an endogenous metabolite in rice grain extract and digest, inhibits β-secretase 1 (BACE1) with IC50 of approximately 0.25 μM.
S6990	Phytohemagglutinin (PHA)	Phytohemagglutinin (PHA) is a glycoprotein from red kidney beans (Phaseolus vulgaris) that acts as a potent mitogen, stimulating lymphocyte proliferation and transforming them into large blast cells. It can suppress humoral antibody responses and enhance the survival of homografts by inhibiting immune rejection. It also triggers T-cell activation and apoptosis by upregulating pro-apoptotic proteins like Bax, leading to the activation of caspase-3.
S5121	Phytol	Phytol (Trans-Phytol), a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, shows antinociceptive and antioxidant activities as well as anti-inflammatory and antiallergic effects. It is a specific activator of PPARα.
E3624	Phytolaccae Radix Extract	Phytolaccae Radix Extract is extracted from Phytolaccae Radix (the dried root of Phytolacca acinosa Roxb. or Phytolacca americana L.). Radix Phytolaccae is widely used for the treatment of inflammation-related diseases.
S9218	Phytolaccagenin	Phytolaccagenin, a triterpenoid saponin, is the active component of Radix Phtolaccae.
S5150	Phytosterols	Phytosterols, also called plant sterols or stanol esters, are specialized compounds found in plants that are structurally similar to cholesterol found in humans.
A5218	PI 3 Kinase p110 delta Rabbit Recombinant mAb	PI 3 Kinase p110 delta Rabbit Recombinant mAb detects endogenous level of total PI3 Kinase p110 delt.
F2032	PI 3 Kinase p85 β Antibody [D1J6]
S1038	PI-103	PI-103 is a multi-targeted PI3K inhibitor for p110α/β/δ/γ with IC50 of 2 nM/3 nM/3 nM/15 nM in cell-free assays, less potent to mTOR/DNA-PK with IC50 of 30 nM/23 nM. PI-103 induces apoptosis in murine T-cell Lymphoma.
E8147	PI-103 Hydrochloride	PI-103 Hydrochloride is a dual PI3K and mTOR inhibitor with IC50s of 8 nM, 88 nM, 48 nM, 150 nM, 20 nM, and 83 nM for p110α, p110β, p110δ, p110γ, mTORC1, and mTORC2. PI-103 Hydrochloride also inhibits DNA-PK with an IC50 of 2 nM. PI-103 Hydrochloride induces autophagy.
E2374	PI-273	PI-273, the first reversibly and specific phosphatidylinositol 4-kinase (PI4KIIα) inhibitor with an IC50 of 0.47 μM, can inhibit breast cancer cell proliferation, block the cell cycle and induce cell apoptosis.
E4638	PI-828	PI-828 is a dual PI3K and casein kinase 2 (CK2) inhibitor with IC50s of 173 nM, 149 nM, and 1127 nM for p110α, CK2, and CK2α2 in lipid kinase assay, respectively.
A5619	PI3 Kinase Class 3 Rabbit Recombinant mAb	PI3 Kinase Class 3 Rabbit Recombinant mAb detects endogenous level of total PI3 Kinase Class 3.
F1515	PI3 Kinase Class II α Antibody [B2P18]	PI 3-kinase C2α,PI3 Kinase Class II α
F1398	PI3 Kinase p101 Antibody [H23D19]
F2645	PI3 Kinase p110 δ Antibody [H17B15]	PI 3 Kinase p110 delta,PI 3-kinase p110δ,PI3 Kinase p110 δ
F0293	PI3 Kinase p110α Antibody [P8E2]	PI 3 Kinase catalytic subunit alpha/PIK3CA,PI3 Kinase p110α
F1205	PI3 Kinase p110β Antibody [A2M11]	PI3 Kinase p110 beta,PI3 Kinase p110β
F4196	PI3 Kinase p110β Antibody [D23E3]
F0643	PI3 Kinase p110γ Antibody [L1P11]	PI 3 Kinase catalytic subunit gamma/PI3K-gamma,PI3 Kinase p110γ
F0850	PI3 Kinase p55 Antibody [N13P24]
A5048	PI3 Kinase p55 gamma Rabbit Recombinant mAb	PI3 Kinase p55 gamma Antibody detects endogenous levels of total PI3 Kinase p55 gamma.
F0294	PI3 Kinase p85 Antibody [A5E17]	PI3 Kinase,PI3 Kinase p85
F1720	PI3 Kinase p85α Antibody [K4G2]	PI 3 Kinase p85 alpha,PI 3-kinase p85α,PI3 Kinase p85α
L2800	PI3K/Akt Inhibitor Library	A unique collection of 355 small molecule inhibitors used for PI3K/Akt/mTOR pathway research.
E4683	PI3K/AKT-IN-1	PI3K/AKT-IN-1 is a dual-acting inhibitor of PI3K/AKT pathway with an IC50 of 6.99 µM, 4.01 µM, and 3.36 µM, for PI3Kδ, PI3Kγ and AKT-1 respectively. It also induces S-phase cell cycle arrest, caspase-3-dependent apoptosis, exhibiting strong potential against breast cancer and leukemia.
E5889	PI3K/Akt/mTOR-IN-2	PI3K/Akt/mTOR-IN-2 is a specific inhibitor of the PI3K/Akt/mTOR signaling pathway. It exhibits an effective anti-cancer activity with IC50 value of 2.29 μM and can induce cancer cell cycle arrest and apoptosis.
E2375	PI3K/mTOR Inhibitor-2	PI3K/mTOR Inhibitor-2 is a potent dual pan-PI3K/mTOR inhibitor with antitumor activity.
E2981	PI4KIIIbeta-IN-10	PI4KIIIbeta-IN-10 is a potent inhibitor of PI4KIIIβ with an IC50 of 3.6 nM. It also exhibits weak inhibition of PI3KC2γ, PI3Kα, and PI4KIIIα, and <20% inhibition at concentrations up to 20 µM for PI4K2α, PI4K2β, and PI3Kβ.
F1048	PIAS1 Antibody [L5H9]
A5316	PIAS1/PIAS2/PIAS3 Rabbit Recombinant mAb	PIAS1/PIAS2/PIAS3 Rabbit Recombinant mAb detects endogenous level of total PIAS1/PIAS2/PIAS3.
F1516	PIAS3 Antibody [G3P18]
F0897	PIAS4 Antibody [D22D4]	E3 SUMO-protein ligase PIAS4/PIASy,PIAS4
E7701	Piboserod	Piboserod (SB 207266) is a selective 5-HT(4) receptor antagonist.IC50 value:Target: 5-HT4 antagonistin vitro: Piboserod did not modify the basal contractions but concentration-dependently antagonized the ability of 5-HT to enhance bladder strip contractions to EFS. In presence of 1 and 100 nM of piboserod, the maximal 5-HT-induced potentiations were reduced to 45.0+/-7.9 and 38.7+/-8.7%, respectively .in vivo: Piboserod significantly increased LVEF by 1.7% vs. placebo (CI 0.3, 3.2, P = 0.020), primarily through reduced end-systolic volume from 165 to 158 mL (P = 0.060). There was a trend for greater increase in LVEF (2.7%, CI -1.1, 6.6, P = 0.15) in a small subset of patients not on chronic beta-blocker therapy. There was no significant eff
S9641	Pibrentasvir (ABT-530)	Pibrentasvir (ABT-530) is a novel and pan-genotypic hepatitis C virus (HCV) NS5A inhibitor with EC50 ranging from 1.4 pM to 5.0 pM against HCV replicons containing NS5A from genotypes 1 to 6.
E7111	Picaridin	Picaridin (Lcaridin) is a broad spectrum arthropod repellent. The repellent and deterrent activities of Picaridin involve olfactory sensing in mosquitoes, and ticks, via their interactions with odorant receptor proteins.
S3026	Piceatannol	Piceatannol, a natural stilbene, is a selective Syk inhibitor and ~10-fold selectivity versus Lyn.
S9138	Picfeltarraenin IA	Picfeltarraenin IA is an AChE inhibitior, and an potential PI3K and EGFR inhibitor. It also acts as an inhibitor on both the classical and alternative pathways of the complement system.
S3246	Picfeltarraenin IB	Picfeltarraenin IB, a cucurbitacin glycoside isolated from Picriafel-terrae, is an inhibitor of acetylcholinesterase (AChE). Picfeltarraenin IB can be used for the treatment of herpes infections, cancer and inflammation.
E4648	Pico145	Pico145(HC-608) is a selective inhibitor of TRPC1/4/5 channels. It inhibits (−)-englerin A-activated TRPC4/TRPC5 channels, with IC50 values of 0.349 and 1.3 nM, respectively. It exhibits no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8.
S4710	Picolinamide	Picolinamide (2-Pyridinecarboxamide, Picolinoylamide, 2-Carbamoylpyridine) is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.
S6249	Picolinic acid (PCL 016)	Picolinic acid (PCL 016) is a pyridine carboxylate metabolite of tryptophan and acts as an anti-infective and immunomodulator. It acts by binding with the zinc associated with zinc finger proteins to alter their structure and inhibit function.
E0242	Picrocrocin	Picrocrocin, the chemical most responsible for the bitter taste of saffron, is isolated from saffron and inhibits proliferation of cancer cells.
S7668	Picropodophyllin (PPP)	Picropodophyllin (PPP, AXL1717) is a IGF-1R inhibitor with IC50 of 1 nM. It displays selectivity for IGF-1R and does not coinhibit tyrosine phosphorylation the IR, or of a selected panel of receptors less related to IGF-IR(FGF-R, PDGF-R, OR EGF-R). Picropodophyllin (PPP) induces apoptosis with antineoplastic activity.
S3787	Picroside I	Picroside I (6'-Cinnamoylcatalpol), an iridoid glycoside, is a hepatoprotective agent which is reported to be antimicrobial and used against hepatitis B.
S3765	Picroside II	Picroside II (6-Vanilloylcatalpol, Vanilloyl catalpol) is the main active ingredient in iridoid glycosides, which is the principal component of Picrorrhiza kurroa Royle. It has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities.
S6100	Picrotoxin	Picrotoxin (Picrotin, Cocculin, Cocculus, NSC 403139), a plant alkaloid, is a non-competitive antagonist of neuronal GABA and glycine receptors.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
S1065	Pictilisib (GDC-0941)	Pictilisib (GDC-0941, RG7321) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Pictilisib (GDC-0941) induces autophagy and apoptosis. Phase 2.
E7814	Pictilisib dimethanesulfonate	Pictilisib dimethanesulfonate (GDC-0941 dimethanesulfonate) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold).
S3106	Pidotimod	Pidotimod(Pidotomod) is an immunostimulant.
S2929	Pifithrin-α (PFTα) HBr	Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes. Pifithrin-α is also a potent agonist of the aryl hydrocarbon receptor (AhR).
E7483	Pifithrin-α, p-Nitro, Cyclic	Pifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form p53 inhibitor. Pifithrin-α, p-Nitro, Cyclic is one order magnitude more active than Pifithrin-α in protecting cortical neurons exposed to Etoposide (ED50=30 nM). Pifithrin-α, p-Nitro, Cyclic behaves as a p53 posttranscriptional activity inhibitor. Pifithrin-α, p-Nitro, Cyclic do not prevent p53 phosphorylation on the S15 residue.
E2943	Pifithrin-β	Pifithrin-β (PFT β hydrobromide; Cyclic Pifithrin-α hydrobromide) is a potent inhibitor of p53 with an IC50 of 23 μM and is regarded as a lead compound for cancer and neurodegenerative disease therapy.
S2930	Pifithrin-μ	Pifithrin-μ (NSC 303580, PFTμ, 2-Phenylethynesulfonamide) is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy.
E3498	Pigeon pea leaves Extract	Pigeon Pea Leaves Extract is extracted from the leaves of Cajanus cajan (L.) Millsp, which has antimicrobial, anti-inflammatory, antitubercular, antioxidant, neuroprotective, antihypertensive, antihyperglycemic, and anticancer properties.
E2823	PIK-108	PIK-108 is a non-ATP competitive, allosteric p110β/p110δ selective inhibitor.
E7171	PIK-75	PIK-75 is a reversible DNA-PK and p110α-selective inhibitor, which inhibits DNA-PK, p110α and p110γ with IC50s of 2, 5.8 and 76 nM, respectively. PIK-75 inhibits p110α >200-fold more potently than p110β (IC50=1.3 μM). PIK-75 induces apoptosis.
S1205	PIK-75 HCl	PIK-75 HCl is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than p110β), isoform-specific mutants at Ser773, and also potently inhibits DNA-PK with IC50 of 2 nM in cell-free assays.
S1489	PIK-93	PIK-93 is the first potent, synthetic PI4K (PI4KIIIβ) inhibitor with IC50 of 19 nM; shown to inhibit PI3Kα with IC50 of 39 nM.
S7683	PIK-III	PIK-III (VPS34-IN2), which is a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and de novo lipidation of LC3 and leads to the stabilization of autophagy substrates. The IC50 values for VPS34 and PI(3)Kδ are 0.018 μM and 1.2 μM respectively.
S5363	Pikamilone	Pikamilone is a drug having a central (vegetotropic and vascular) and peripheral (vasodilating) mechanisms of action.
S7645	Pilaralisib (XL147)	Pilaralisib (XL147) is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ with IC50 of 39 nM/36 nM/23 nM in cell-free assays, less potent to PI3Kβ. Phase 1/2.
E7001	Pilocarpine	Pilocarpine is a non-selective agonist of muscarinic acetylcholine receptor (mAChR), commonly used to treat xerostomia and glaucoma. It modulates the electrical properties of heart cells, likely by activating a potassium (K+) current mediated by M3 receptors.
S4231	Pilocarpine HCl	Pilocarpine HCl (NSC 5746) is a selective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy.
F0857	Pim-1 Antibody [C2K23]
F0754	Pim-2 Antibody [J4J24]	PIM2,Pim-2
F0808	Pim-3 Antibody [H6L6]
A5639	PIM1 Rabbit Recombinant mAb	PIM1 Rabbit Recombinant mAb detects endogenous level of total PIM1.
F3887	PIM2 Antibody [L18N23]
E8144	PIM447	PIM447 (LGH447) is a potent, orally available, and selective pan-PIM kinase inhibitor, with Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively. PIM447 displays dual antimyeloma and bone-protective effects. PIM447 induces apoptosis.
S7985	PIM447 (LGH447) Hydrochloride	PIM447 (LGH447) Hydrochloride is a novel pan-PIM kinase inhibitor with Ki values of 6 pM, 18 pM, 9 pM for PIM1, PIM2, PIM3 respectively. It also inhibits GSK3β, PKN1, and PKCτ, but at a significantly lower potency with IC50 between 1 and 5 μM (>10⁵-fold differential relative to the Ki on PIMs). PIM447 induces apoptosis.
S1475	Pimasertib (AS-703026)	Pimasertib (AS-703026, MSC1936369B, SAR 245509) is a highly selective, potent, ATP non-competitive allosteric inhibitor of MEK1/2 with IC50 of 5 nM-2 μM in MM cell lines. Phase 2.
E8211	Pimavanserin	Pimavanserin is a selective inverse agonist of the 5-HT2A receptor with pIC50 and pKd of 8.73 and 9.3, respectively.
S8183	Pimavanserin tartrate	Pimavanserin tartrate(ACP-103) is a potent and selective serotonin 5-HT2A inverse agonist with pIC50 of 8.73, used to treat psychosis associated with Parkinson’s disease.
S5004	Pimecrolimus	Pimecrolimus (Elidel,ASM 981,SDZ-ASM 981) is an immunophilin ligand, which binds specifically to the cytosolic receptor, immunophilin macrophilin-12 (FKBP-12); a calcineurin inhibitor.
S3145	Pimelic acid	Pimelic acid (Heptanedioic acid, 1,5-Pentanedicarboxylic acid, 1,7-Heptanedioic acid) originating from fatty acid synthesis pathway is a bona fide precursor of biotin in B. subtilis.
E4862	Pimethixene	Pimethixene(Calmixen, Pimetixene) is a highly potent and non-selective antagonist of the 5-HT_2B receptor, with a pKi of 10.44. It also functions as an antihistamine and anticholinergic agent, and is a highly potent multi-target antagonist with antagonistic effects on multiple receptors.
S3913	Pimethixene maleate	Pimethixene (Pimetixene) maleate, an antihistamine, anntimigraine agent and antiserotonergic compound, is a highly potent antagonist of a broad range of monoamine receptors, including a variety of serotonin receptors. Pimethixene maleate inhibits 5-HT2A, 5-HT2B, 5-HT2C, 5-HT1A, 5-HT1B, 5-HT6, 5-HT7, Adrenergic α-1A, Dopamine D1 Receptor, Dopamine D2 Receptor, Dopamine D4.4 Receptor, Histamine H1 Receptor, Muscarinic M1 and Muscarinic M2 with pKi of 10.22, 10.44, 8.42, 7.63, < 5, 7.30, 7.28, 7.61, 6.37, 8.19, 7.54, 10.14, 8.61 and 9.38, respectively.
E1727	Pimicotinib	Pimicotinib (ABSK021) is an orally bioavailable inhibitor of colony stimulating factor 1 receptor (CSF1R). It enhances antitumor T-cell immune responses and inhibits the proliferation of tumor cells having potential immunomodulatory and antineoplastic activities.
S7716	Pimitespib (TAS-116)	Pimitespib (TAS-116) is a novel, small-molecule HSP90 inhibitor which inhibits geldanamycin-FITC binding to HSP90 proteins with Ki values of 34.7 nmol/L, 21.3 nmol/L, >50,000 nmol/L, and >50,000 nmol/L for HSP90α, HSP90β, GRP94, and TRAP1, respectively. Furthermore, TAS-116 does not inhibit other ATPases such as HSP70 (IC50 >200 μmol/L).
S1550	Pimobendan	Pimobendan (UD-CG 115 BS) is a selective inhibitor of PDE3 with IC50 of 0.32 μM.
S9919	Pimonidazole	Pimonidazole (Ro 03-8799) is a novel hypoxia marker used for complementary study of tumor hypoxia and cell proliferation in cervical carcinoma.
S4358	Pimozide	Pimozide (Orap, R6238) is an antagonist of Dopamine Receptors with Ki of 0.83 nM, 3.0 nM and 6600 nM for dopamine D3, D2 and D1 receptors, respectively. Pimozide also exhibits binding affinity at 5-HT1A and α1-adrenoceptor with Ki of 310 nM and 39 nM, respectively. Pimozide is an antipsychotic drug with anti-tumor activity and suppresses STAT3 and STAT5 activity.
S6893	PIN1 inhibitor API-1	PIN1 inhibitor API-1 is a specific Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) inhibitor with IC50 of 72.3 nM. PIN1 inhibitor API-1 targets Pin1 peptidyl-prolyl isomerase domain and inhibits Pin1 cis-trans isomerizing activity. PIN1 inhibitor API-1 up-regulates miRNA biogenesis by retaining active XPO5 conformation and suppresses HCC development.
D4017	Pinatuzumab vedotin	Pinatuzumab Vedotin (RG-7593, DCDT2980S, DCDT-2989S), is an antibody-drug conjugate (ADC) composed of CD22 (Sialic acid binding Ig-like lectin 2, SIGLEC2, SIGLEC-2, B-lymphocyte cell adhesion molecule, BL-CAM, Leu-14) antibody and cytotoxic agent monomethyl auristatin E (MMAE) conjugated through maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl (mc-val-cit-PABC) type linker.
S6473	Pinaverium bromide	Pinaverium bromide (Icosapentaenoic acid) acts as a calcium channel blocker and is useful for functional gastrointestinal disorders.
E3670	Pine Bark Extract	Pine Bark Extract is extracted from Pine bark. Pine bark extract is rich in bioflavonoids, predominantly proanthocyanidins, which are antioxidants. Pine Bark extract is used for preventing or treating various chronic conditions associated with oxidative stress. This is an update of a previously published review.
E3672	Pine needles Extract	Pine Needles Extract is extracted from the needles of Pinus Linn.
E3669	Pine Nodular Branch Extract	Pine Nodular Branch Extract is extracted from the branch of Pinus Linn.
E3673	Pine nuts Extract	Pine Nuts Extract is extracted from the nuts of Pinus Linn.
E3667	Pine pollen Extract	Pine pollen Extract is extracted from the pollen of Pinus massoniana Lamb.
F0490	PINK1 Antibody [B2H2]
F3247	PINK1 Antibody [M4A21]
S3941	Pinocembrin	Pinocembrin (Dihydrochrysin, Galangin flavanone, 5,7-Dihydroxyflavanone) is a major flavonoid molecule incorporated as multifunctional in the pharmaceutical industry. Its vast range of pharmacological activities has been well researched including antimicrobial, anti-inflammatory, antioxidant, and anticancer activities.
S7062	Pinometostat (EPZ5676)	Pinometostat (EPZ5676) is an S-adenosyl methionine (SAM) competitive inhibitor of protein methyltransferase DOT1L with K_i of 80 pM in a cell-free assay, demonstrating >37,000-fold selectivity against all other PMTs tested, inhibits H3K79 methylation in tumor. Phase 1.
S9436	Pinoresinol dimethyl ether	Pinoresinol dimethyl ether, which could be isolated from the wood of the basal tree Humbertieae, show a variety of activities as the inhibitor of cyclic AMP phosphodiesterase.
E3243	Pinus Pinaster Bark Extract	Pinus Pinaster Bark Extract is extrcated from the bark of Pinus Pinaster, which has anti-inflammatory actions.
S2590	Pioglitazone	Pioglitazone is a selective peroxisome proliferator-activated receptor-gamma (PPARγ) agonist, used to treat diabetes; A weak activator for full-length hPPARα, but not full-length hPPARδ.
S2046	Pioglitazone HCl	Pioglitazone HCl (AD-4833, U-72107E) is an inhibitor of cytochrome P450 (CYP)2C8 and CYP3A4 enzymes. Pioglitazone HCl inhibits CYP2C8, CYP3A4 and CYP2C9 with Ki of 1.7 μM, 11.8 μM and 32.1 μM, respectively. Pioglitazone HCl is also a selective peroxisome proliferator-activated receptor-gamma (PPARγ) agonist with EC50 of 0.93 μM and 0.99 μM for human PPARγ and mouse PPARγ, respectively. Pioglitazone HCl inhibits mitochondrial iron uptake, lipid peroxidation, and subsequent ferroptosis.
F1237	PIP4K2A Antibody [L5H16]
S6322	Pipecolic acid	Pipecolic acid (piperidine-2-carboxylic acid), a metabolite of lysine found in human physiological fluids such as urine, plasma and CSF, is an important regulator of immunity in plants and humans alike.
S5051	Pipemidic acid	Pipemidic acid (Acido pipemidico) is a pyridopyrimidine antibiotic derivative of piromidic acid with activity against gram-negative bacteria including Pseudomonas aeruginosa and some gram-positive bacteria. Pipemidic acid is an inhibitor of DNA gyrase that is a bacterial enzyme which catalyzes the ATP-dependent negative supercoiling of DNA. It can be used for the research of intestinal, urinary, and biliary tract infections.
E7963	Pipequaline	Pipequaline (PK 8165) is a partial benzodiazepine receptor agonist with anxiolytic activity.
E3426	Piper betle L. Extract	Piper Betle L. Extract is extracted from Piper betel l., which is a potential source of wound healing agents.
E3059	Piper longum Extract	Piper longum Extract is the aqueous extract of Piper longum root, is hopeful in preventing hyperglycemia, cardiovascular, hepatic and renal diseases.
E3294	Piper Nigrum Seed Extract	Piper Nigrum Seed Extract is extracted from Piper nigrum L., which has antimicrobial activity, antioxidant effects, antidiabetic activity, hypolipidemic activity, anti-inflammatory, analgesic, anticonvulsant, and neuroprotective effects.
E8115	Piperacetazine	Piperacetazine (Quide, Psymod) is a potent inhibitor of PAX3::FOXO1 and a prodrug of a phenothiazine antipsychotic drug with a mechanism of action similar to chlorpromazine. Piperacetazine has antitumor activity.
E4810	Piperacillin	Piperacillin is a broad-spectrum β-lactam antibiotic with potent bactericidal activity against Gram-negative bacteria and selects Gram-positive strains via penicillin-binding proteins.
S4222	Piperacillin Sodium	Piperacillin (CL227193,Pipracil) is a semisynthetic, broad-spectrum, ampicillin derived ureidopenicillin antibiotic proposed for pseudomonas infections.
S5355	Piperaquine phosphate	Piperaquine phosphate is an orally active bisquinolone antimalarial drug.
E4809	Piperaquine tetraphosphate tetrahydrate	Piperaquine tetraphosphate tetrahydrate is an inhibitor of autophagy . It is a bisquinoline antimalarial agent effective against Plasmodium falciparum. Piperaquine tetraphosphate tetrahydrate is useful in antimalarial research.
S4443	Piperazine adipate	Piperazine adipate is a broad spectrum anthelmintic agent that inhibits malate oxidation in Ascaridia galli and Heterakis gallinae.
E1063	Piperazine Erastin	Piperazine Erastin is an analog of Erastin, which can induces ferroptosis in cancer cells, an iron-dependent form of nonapoptotic cell death.
S2344	Piperine	Piperine (1-Piperoylpiperidine) is the alkaloid responsible for the pungency of black pepper and long pepper, which has also been used in some forms of traditional medicine and as an insecticide.
E3245	Piperis Kadsurae Caulis Extract	Piperis Kadsurae Caulis Extract is extracted from Piperis Kadsurae Caulis., which can reduce the expression level of IL-1β and TNF-α in cells.
S7551	Piperlongumine	Piperlongumine (PPLGM, Piplartine), a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells.
S6139	Piperonyl acetone	Piperonyl acetone is a food additive used in food flavouring.
S4831	Piperonyl butoxide	Piperonyl butoxide (PBO, Butacide, Ethanol butoxide, Pyrenone 606,ENT-14250) is a man-made pesticide synergist, working with insect killers to increase their effectiveness.Piperonyl butoxide is an inhibitor of cytochrome P450 monooxygenases(P450s).
S0116	Piperoxan hydrochloride	Piperoxan hydrochloride (Benodaine, Fourneau 933, F933, DL-Piperoxan) is an antagonist of α2 (alpha 2) adrenoceptor.
E2941	PIPES	PIPES (1,4-Piperazinediethanesulfonic acid) is an important component of PIPES buffer agent used in biochemistry. PIPES buffer in combination with glutaraldehyde and formaldehyde helps in optimal fixation of fungal zoospores for fluorescence microscopy and electron microscopy.
S4447	Pipobroman	Pipobroman (PB, Vercyte), a neutral amide of piperazine, acts as an alkylating agent with antiproliferative activity.
S3070	Piracetam	Piracetam (UCB 6215) is a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), used in treatment of a wide range of cognitive disorders.
S1393	Pirarubicin	Pirarubicin is an anthracycline antibiotic, and also a DNA/RNA synthesis inhibitor by intercalating into DNA and interacts with topoisomerase II, used as an antineoplastic agent.
S0779	Pirenperone	Pirenperone (R-47456, R-50656), a quinazoline derivative, is a selective antagonist of SR-2A (5-HT2 serotonin receptor) when employed in low doses. Pirenperone behaves like a typical neuroleptic when used in higher doses (greater than 0.1 mg/kg).
S3662	Pirenzepine dihydrochloride	Pirenzepine is an antimuscarinic agent which inhibits gastric acid secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular and urinary functions.
S2907	Pirfenidone	Pirfenidone is an inhibitor for TGF-β production and TGF-β stimulated collagen production, reduces production of TNF-α and IL-1β, and also has anti-fibrotic and anti-inflammatory properties. Pirfenidone attenuates chemokine (CC motif) ligand-2 (CCL2) and CCL12 production with anti-fibrotic activity. Phase 3.
S3656	Piribedil	Piribedil (Trivastal, Trivastan) is a relatively selective dopamine (D2/D3) agonist with moderate antidepressant activity. It also has α2-adrenergic (α2A/α2C) antagonist properties.
E7226	Pirimiphos-methyl	Pirimiphos-methyl is a rapid-acting organophosphorus insecticide and acaricide, causing inhibition of AChE in target organisms. Pirimiphos-methyl is often used for prevention and control of beetles, snout beetles, moths and Ephestia cautella during storage of agricultural grains.
S5213	Piroctone Olamine	Piroctone Olamine (piroctone ethanolamine) is a wide spectrum antibacterial and antifungal agent used in the treatment of dandruff,fungal infections.
E7091	Pirodavir	Pirodavir is a potent, broad-spectrum picornavirus inhibitor, and is highly active against both group A and group B rhinovirus serotypes.Pirodavir is very potent in a virus yield reduction assay (IC90=2.3 nM).
S1713	Piroxicam	Piroxicam (CP 16171) is a non-selective COX inhibitor, used in the treatment of rheumatoid and osteoarthritis.
S0159	Pirozadil	Pirozadil is a hypolipidemic agent.
S9825	Pirtobrutinib (LOXO-305)	Pirtobrutinib (LOXO-305, LY 3527727, RXC-005) is a highly selective, non-covalent, next generation BTK inhibitor with an IC50 of 5.69 nM in WT BTK HEK cells. Pirtobrutinib shows more than 300-fold selective for BTK over 98% of 370 other kinases.
E3712	Pisum sativum Extract	Pisum Sativum Extract is obtained from Pisum sativum L. (Fabaceae), which has antioxidant, antimicrobial and hypoglycemic activities.
E6038	Pitavastatin	Pitavastatin (NK-104) is a highly potent inhibitor of HMG-CoA reductase with an IC50 of 6.8 nmol/L, which significantly enhances LDL receptor activity and lowers LDL cholesterol (LDL-C) levels. It also inhibits cholesterol synthesis in vitro and has the potential to manage hypercholesterolemia and reducing cardiovascular risk.
S1759	Pitavastatin calcium	Pitavastatin calcium, a novel member of the medication class of statins, is a calcium salt formulation of pitavastatin which is a highly effective HMG-CoA reductase inhibitor. Pitavastatin Calcium attenuates AGEs-induced mitophagy via inhibition of ROS generation. Pitavastatin Calcium induces autophagy and apoptosis.
E4955	Pitolisant	Pitolisant(BF2.649, Tiprolisant) is a potent, selective antagonist of the non-imidazole histamine H3 receptor, with a Ki value of 0.16 nM and an EC50 of 1.5 nM as an inverse agonist. It enhances the activity of histaminergic neurons, promoting vigilance and cognitive function. It is useful in research on wakefulness, memory deficits, and cognitive disorders.
S5926	Pitolisant hydrochloride	Pitolisant (Tiprolisant, BF-2649) acts as a high-affinity competitive antagonist (Ki=0.16 nM) and as an inverse agonist (EC50=1.5 nM) at the human histamine H3 receptor subtype.
F2651	PITSLRE/CDK11 Antibody [K17G19]
S9670	Pitstop 2	Pitstop 2 is an inhibitor of the interaction of amphiphysin with the amino terminal domain of clathrin that inhibits both clathrin-dependent endocytosis (CDE) and clathrin independent endocytosis (CIE).
E8228	pivalic acid-d9	Pivalic acid D9 is the deuterated product of trimethylacetic acid. Trimethylacetic acid is an organic acid, mainly used as a drug synthesis intermediate for the preparation of antibiotics, antiallergic drugs and surfactants.
S5473	Pivmecillinam hydrochloride	Pivmecillinam is a β-lactam antibiotic and a prodrug of mecillinam. It has selective activity against Gram-negative bacteria and is used primarily in the treatment of lower urinary tract infections.
S5059	Pixantrone Maleate	Pixantrone (BBR-2778) is a novel aza-anthracenedione compound with antitumor activity. It is a weak topoisomerase II inhibitor and forms stable DNA adducts through alkylation with specificity for DNA hypermethylated sites.
S5770	Pizotifen	Pizotifen (Pizotyline, BC-105) is a potent antagonist of 5-Hydroxytryptamine (5-HT, Serotonin) 5-HT2 receptor with a high affinity for 5-HT1C binding site.
S1394	Pizotifen Malate	Pizotifen Malate (Sandomigran, pizotyline,BC-105) is a benzocycloheptane based agent used for recurrent migraine headaches.
E4637	PK 11195	PK 11195 (RP 52028) is a translocator protein (TSPO) ligand, a potent and selective antagonist of peripheral benzodiazepine receptorwith high affinity Ki of 3.1 nM in cerebellum and 4.1 nM in spinal cord. It is also an antagonist of human constitutive androstane receptor (hCAR), and human pregnane X receptor (PXR). It displaces [3H] RO5-4864 from its binding sites across organs and also targets Leishmania in chemotherapy.
S8728	PK11000	PK11000 stabilizes the DBD of both WT and mutant p53 proteins by covalent cysteine modification without compromising DNA binding and effective in inducing cell death.
E1735	PK11007	PK11007 is a thiol-reactive anticancer agent that stabilizes p53 via selective alkylation of two surface cysteines without compromising its DNA binding. It induces mutant p53 cancer cell death by increasing reactive oxygen species (ROS) levels.
S0534	PK150	PK150 is an analogue of Sorafenib, which shows oral bioavailability and antibacterial activity against several pathogenic strains at submicromolar concentrations. PK150 inhibits Gram-positive Methicillin-sensitive S. aureus (MSSA), Methicillin-resistant S. aureus (MRSA), Vancomycin intermediate S. aureus (VISA) with MICs of 0.3, 0.3-1, 0.3 µM, respectively.
E2367	PK68	PK68 is a potent orally active and specific inhibitor of receptor-interacting kinase 1 (RIPK1) with an IC50 of ~90 nM.
F0588	PKA C-α Antibody [P7L4]	cAMP Protein Kinase Catalytic subunit,PKA C-α
F3842	PKA R2/PKR2 Antibody [D10M9]
F1294	PKA RI-α Antibody [J14D6]
A5782	PKA2 beta Rabbit Recombinant mAb	PKA2 beta Rabbit Recombinant mAb detects endogenous levels of total PKA2 beta.
A5162	PKC alpha Rabbit Recombinant mAb	PKC alpha Rabbit Recombinant mAb detects endogenous level of PKC alpha.
A5817	PKC beta 1 Rabbit Recombinant mAb	PKC beta 1 Rabbit Recombinant mAb detects endogenous levels of total PKC beta 1
A5519	PKC beta 2 Rabbit Recombinant mAb	PKC beta 2 Rabbit Recombinant mAb detects endogenous level of total PKC beta 2.
A5215	PKC eta Rabbit Recombinant mAb	PKC eta Rabbit Recombinant mAb detects endogenous level of total PKC eta.
A5531	PKC theta Rabbit Recombinant mAb	PKC theta Rabbit Recombinant mAb detects endogenous level of total PKC theta.
F2343	PKC ζ Antibody [C22E16]	PKC zeta,PKC ζ,PKCζ
F0745	PKC ζ Antibody [J7H1]	PKC zeta,PKC ζ,PKCζ
S6577	PKC-theta inhibitor	PKC-theta inhibitor (compound 20) inhibits PKC-θ with an IC50 of 18 nM.
F1008	PKCα Antibody [H18C22]	PKC,PKC alpha,PKC α,PKCα,Protein Kinase Calpha
F3769	PKCδ Antibody [G9A5]	PKC delta,PKC δ,PKCδ
F0644	PKCε Antibody [N2L13]	PKC epsilon,PKC ε,PKCε
F0898	PKCθ Antibody [C21J10]	PKC theta/PRKCQ,PKC θ,PKCθ
F0899	PKCι/λ Antibody [M11C7]
F3042	PKD/PKCμ Antibody [D22N3]	PKC mu/PKD,PKD/PKCμ,PRKD1
F1238	PKD2 Antibody [F19K7]
F0792	PKD3/PKCν Antibody [N18G12]
S0152	PKG drug G1	PKG drug G1 is an activater of Protein Kinase G Iα (PKG Iα) targeting C42, resulting vasodilation and blood pressure lowering.
P1153	PKG inhibitor peptide	PKG inhibitor peptide is an ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG), with a Ki of 86 μM.
F0589	PKG-1 Antibody [B18P19]
P1154	PKI 14-22 amide,myristoylated	PKI 14-22 amide, myristoylated is a potent cAMP-dependent PKA inhibitor, which can reduce the IgG-mediated phagocytic response and also inhibits neutrophil adhesion.
E7109	PKI(5-24)	PKI(5-24) is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a Ki of 2.3 nM. It can be used for research to study hormonal regulation of the CAMP-dependent protein kinase.
S2739	PKI-402	PKI-402 is a potent dual pan-PI3K/mTOR inhibitor targeting PI3Kα/β/γ/δ and mTOR with IC50 of 2 nM/7 nM/16 nM/14 nM and 3 nM, respectively; also potent to PI3Kα mutants E545K and H1047R.
F0491	PKM1 Antibody [H3D14]
F0793	PKM1/2 Antibody [E6H20]	PKM,PKM1/2
F0295	PKM2 Antibody [F23E18]
F2704	PKM2 Antibody [L22N15]
S8616	PKM2 inhibitor(compound 3k)	PKM2 inhibitor(Compound 3K, PKM2-IN-1) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.
E6517	PKN1
A5157	PKN2 Rabbit Recombinant mAb	PKN2 Rabbit Recombinant mAb detects endogenous level of PKN2.
F4608	PKR Antibody [F1M21]
F1207	PKR Antibody [K23G2]
E2388	PKR-IN-2	PKR-IN-2 is a pyruvate kinase isoform PKR activator extracted from patent WO2014139144A1, compound 160, which can be used for the research of PKR function related diseases, including cancer, diabetes, obesity, autoimmune disorders, and benign prostatic hyperplasia.
S9668	PKR-IN-C16	PKR-IN-C16 (imoxin, C16, Imidazolo-oxindole PKR inhibitor C16) is a specific inhibitor of RNA-dependent protein kinase (PKR, Protein Kinase R, EIF2AK2). PKR-IN-C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component.
E4677	PKUMDL-LC-101-D04	PKUMDL-LC-101-D04(GPX4-Activator-1d4) is a potent allosteric activator of Glutathione peroxidase 4 (GPX4) effectively suppressing ferroptosis and inflammation. It enhances GPX4 activity by 150% at 20 µM in a cell-free assay and 61 µM in cell extracts, also providing protection against cholesterol hydroperoxide (ChOOH)-induced damage.
F1350	Plac8 Antibody [P15H12]
A5917	Placental alkaline phosphatase(PLAP) Rabbit Recombinant mAb	Placental alkaline phosphatase (PLAP) Rabbit Recombinant mAb detects endogenous levels of total placental alkaline phosphatase.
L9800	Plant Extract Library	A unique collection of 794 plant extracts for high throughput screening (HTS) and high content screening (HCS).
E3088	Plantaginis Herba Extract	Plantaginis Herba Extract is obtained from the dried whole plant of Plantaginaceae family, is famous for the curative effects in promoting urination and treating stranguria in traditional Chinese medicine.
E3089	Plantaginis Semen Extract	Plantaginis Semen Extract is drawed from Plantaginis Semen, has significant effects on anti-hyperuricemia, anti-inflammatory and renal protection, and attenuates potassium oxonate-induced hyperuricemia through regulation of lipid metabolism disorder.
S3254	Plantagoside	Plantagoside, a flavanone glucoside isolated from the seeds of Plantago asiatica, is a specific and non-competitive alpha-mannosidase inhibitor with IC50 of 5 μM.
S9077	Plantamajoside	Plantamajoside (Y0160, C10485), a hydroxycinnamic acid, is used as a biomarker in chemotaxonomical studies, and is a compound with numerous biological applications and considerable pharmacological potential.
E3080	Platycladi Cacumen Extract	Platycladi Cacumen Extract is extracted from Platycladi Cacumen, which has been traditionally used to resist alopecia and promote hair growth.
F0492	PLC1 Antibody [H3H20]	Phospholipase C gamma 1/PLC-gamma-1,PLC γ1,PLCgamma-1,PLCγ1
A5277	PLCG1 Rabbit Recombinant mAb	PLCG1 Rabbit Recombinant mAb detects endogenous level of total PLCG1.
F3015	PLCγ2 Antibody [P20P21]	PLC γ2,PLCγ2
F1493	PLD2 Antibody [B7K12]
P1121	Plecanatide	Plecanatide, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide activates GC-C receptors to stimulate cGMP synthesis with an EC50 of 190 nM in T84 cells assay. Plecanatide shows anti-inflammatory activity in models of murine colitis.
S0436	Pleconaril	Pleconaril (APO-P001, Picovir, VP 63843, WIN 63843) is a capsid inhibitor used previously to treat enterovirus infections. Pleconaril is effective in inhibiting replication with IC50 of < 0.050 μM.
F2118	Plectin Antibody [G16H14]	Plectin,Plectin-1
S8030	Plerixafor (AMD3100)	Plerixafor (AMD3100, JM 3100, SID791) is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. Plerixafor inhibits human immunodeficiency virus (HIV) replication.
S3013	Plerixafor (AMD3100) 8HCl	Plerixafor (AMD3100, JM 3100,Plerixafor Octahydrochloride,AMD3100 octahydrochloride,SID791 octahydrochloride) 8HCl is the hydrochloride of Plerixafor, a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. Plerixafor can be used as an anti-HIV agent.
S4436	Pleuromutilin	Pleuromutilin (Drosophilin B, Mutilin 14-glycolate), the lead compound for novel antibiotics, inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of bacteria.
E3780	Pleurotus eryngii Extract	Pleurotus eryngii Extract is derived from Pleurotus eryngii, which manages neurological disorders such as dementia, Alzheimer’s and Parkinson’s diseases.
E3536	Pleurotus ostreatus Extract	Pleurotus ostreatus Extract is extracted from Pleurotus ostreatus, which decreases the proliferation of leukaemia cells through apoptosis.
F1351	Plexin A4 Antibody [G22C13]
P1244	PLGA (50:50)	PLGA (50:50) (poly(lactic-co-glycolic acid) (50:50)) is a copolymer of poly lactic acid (PLA) and poly glycolic acid (PGA) which can be used to fabricate devices for drug delivery and tissue engineering applications.
S8145	Plicamycin	Plicamycin (Mithramycin A) a selective inhibitor of Sp1, is a natural polycyclic aromatic polyketide isolated from Streptomyces strains. It binds to GC-rich DNA sequences, displacing Sp1 transcription factor from oncogene promoters, inhibiting their expression, with anti-tumor and neuroprotective effects.
S1176	Plinabulin	Plinabulin is a vascular disrupting agent (VDA) against tubulin-depolymerizing with IC50 of 9.8~18 nM in tumor cells. Phase 1/2.
S7965	Plixorafenib (PLX8394)	Plixorafenib (PLX8394) is a next-generation, orally available, small-molecule BRAF inhibitor with IC50 values of 3.8 nM, 14 nM and 23 nM for BRAF(V600E), WT BRAF and CRAF respectively. It has potential antineoplastic activity.
F3264	PLK1 Antibody [F22N13]	Plk,PLK1
F0393	PLK1 Antibody [P4E9]	Plk,PLK1
F1257	PLK3 Antibody [M9B6]
A2569	Plozalizumab (Anti-CCR2 / CD192)	Plozalizumab (Anti-CCR2 / CD192) is a specific humanized monoclonal antibody targeting CCR2. Plozalizumab can be used for malignant melanoma research. MW:145.5 KD.
S0515	PLpro inhibitor	PLpro inhibitor (compound 6) is a potent papain-like protease (PLpro)/deubiquitinase (DUBs) inhibitor with IC50 of 2.6 μM and EC50 of 13.1 μM that blocks SARS virus replication.
E3413	Plum Extract	Plum Extract is extracted from Prunus domestica, which has health benefits for muscles due to its ability to promote myogenesis, stimulate muscle protein synthesis, and inhibit protein degradation.
S4777	Plumbagin	Plumbagin (Plumbagine, Plumbaein, Plumbagone), a quinoid constituent isolated from the root of the medicinal plant Plumbago zeylanica L, exerts anticancer and antiproliferative activities in animal models and in cell culture.
E3323	Plumeria Rubra Extract	Plumeria Rubra Extract is extrcated from Plumeria Rubra, which is used to treat cardiovascular disorders.
S7752	Pluripotin (SC1)	Pluripotin (SC1) is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. Maintains embryonic stem cell (ESC) self-renewal. Pluripotin also inhibits RSK1, RSK2, RSK3 and RSK4 with IC50 of 0.5 µM, 2.5 µM, 3.3 µM and 10.0 µM, respectively.
S8076	PluriSIn #1 (NSC 14613)	PluriSIn #1 is an inhibitor of the stearoyl-coA desaturase 1 (SCD1), which is able to selectively eliminate hPSCs.
S6936	Pluronic F-68	Pluronic F-68 (Poloxamer 188, P188, MST-188) is a triblock copolymer of the form polyethylene oxide-polypropylene oxide-polyethylene oxide (PEO-PPO-PEO) with surface-active properties. Pluronic F-68 is used in the pharmaceutical industry as an excipient in various formulations and drug delivery systems. Pluronic F-68 is effective in the repair/recovery of damaged cell membranes.
S1152	PLX-4720	PLX4720 is a potent and selective inhibitor of B-Raf^V600E with IC50 of 13 nM in a cell-free assay, equally potent to c-Raf-1(Y340D and Y341D mutations), 10-fold selectivity for B-RafV600E than wild-type B-Raf.
S8739	PLX51107	PLX51107 is as a novel BET inhibitor with modest preference for bromodomain-1 (BD1) versus bromodomain-2 (BD2) within each BET protein (Kd = 1.6, 2.1, 1.7, and 5 nM for BD1 and 5.9, 6.2, 6.1 and 120 nM for BD2 of BRD2, BRD3, BRD4, and BRDT, respectively. Among non-BET proteins, PLX51107 shows significant interactions only with the bromodomains of CBP and EP300 (p300) (Kd in the 100 nM range).
S8874	PLX5622	PLX5622 is a highly selective CSF-1R inhibitor (IC50 < 10 nmol/L), showing > 20-fold selectivity over KIT and FLT3.
P1167	pm26TGF-β1 peptide (TFA)	Pm26TGF-β1 peptide TFA is a peptide is a portion of the human TGF-β1 molecule, which shows high affinity for the TGF-β1 receptor.
E8284	PM534	PM534 is a potent microtubule-targeting agent (MTA) that binds the colchicine-binding domain (CBD) and inhibits tubulin assembly with IC50 values ranging from 0.8 to 3.2 nM. It also significantly inhibits tumor growth in mouse xenograft models of human non-small cell lung cancer.
A4003	Pm8002 (Anti-PD-L1 & VEGF)	Pm8002 is a bispecific antibody targeting both PD-L1 and VEGF-A, with potential immune checkpoint inhibition, anti-angiogenic, and antineoplastic activities. It demonstrates promising antitumor effects in patients with previously treated platinum-resistant recurrent ovarian cancer (PROC) or cervical cancer, as well as in those with advanced solid tumors. MW : 172.48 KD.
S7791	PMA (Phorbol 12-myristate 13-acetate)	PMA (Phorbol 12-myristate 13-acetate), a potent activator of PKC, is active at nanomolar concentrations. Phorbol 12-myristate 13-acetate (PMA) induces sphingosine-1-phosphate (S1P).PMA has strong excitability on the skin and mucous membrane. Special protection is required when using PMA. Wear gloves and mask to avoid direct contact in any way.
F2711	PMCA ATPase Antibody [C12G10]
F2539	PML Antibody [F17K6]	PML,PML Protein
S0189	PMPA tetrasodium salt	PMPA tetrasodium salt (PMPA sodium) is a potent and selective inhibitor of glutamate carboxypeptidase 2 (GCP II/NAALADase).
F2023	PMS2 Antibody [N24N11]
S3025	PMSF	PMSF (Phenylmethylsulfonyl Fluoride, Benzylsulfonyl fluoride) is an irreversible serine/cysteine protease inhibitor.
P1208	PMX 205 acetate	PMX 205 acetate is a cyclic hexapeptide that acts as a potent C5a receptor (C5aR, CD88) antagonist with an IC50 of 31 nM.
S6239	PMX-53	PMX-53 is a potent CD88 (C5aR) antagonist and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 values of 22 nM and 75 nM, respectively. PMX-53 is also an agonist of Mas-related gene 2 (MrgX2).
S9200	Pneumocandin B0	Pneumocandin B0 (L-688786) is a natural product and a key intermediate in the synthesis of the antifungal agent.
S4614	PNPP	PNPP (p-nitrophenyl phosphonate) is a substrate for alkaline and acid phosphatases used in enzyme-linked immunoassay (ELISA) and conventional spectrophotometric assays.
S5930	PNU 282987 HCl	PNU 282987 is a potent agonist of α7-containing neuronal nicotinic acetylcholine receptors with Ki value of 26 nM for the rat receptor.
S2629	PNU-120596	PNU-120596 (Nsc 216666) is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM.
S0720	PNU-282987	PNU-282987 is a novel selective agonist of the alpha7 nAChR with Ki of 26 nM for rat alpha7 nAChR. PNU-282987 shows no activity at all tested monoamine, muscarine, glutamate, and GABA receptors, except 5-HT3 receptors with Ki of 930 nM.
S0521	PNU-282987 S enantiomer free base	PNU-282987 S enantiomer free base is the S-enantiomer of PNU-282987 free base, which is an α7 nicotinic acetylcholine receptor (α7 nAChR) agonist.
S8429	PNU-74654	PNU-74654 disrupts the Wnt signaling pathway via inhibition of the interaction (KD50=450 nM) between β-catenin and Tcf4.
S2345	Podophyllotoxin (Podofilox)	Podophyllotoxin (Condylox,Podofilox) is a lignan (lignans) found in podophyllin resin from the roots of podophyllum plants.
F0746	PODXL Antibody [F8E16]	PODXL,TRA-1-60,TRA-1-60 (Podocalyxin),TRA-1-60 (R),TRA-1-60(S) (TRA-1-60(S))
S9094	Pogostone	Pogostone is one of the secondary metabolites from Pogostemon cablin (Blanco) Benth. (Lamiaceae), serving as the effective component of the antimicrobial activity.
D4012	Polatuzumab vedotin-piiq	Polatuzumab vedotin-piiq (polatuzumab vedotin, DCDS4501A, RG7596) is an antibody-drug conjugate (ADC) composed of a monoclonal antibody against CD79b (a B cell receptor component) and the anti-mitotic cytotoxic agent monomethyl auristatin (MMAE). It is used for the treatment of relapsed/refractory diffuse large B-cell lymphoma (DLBCL).
F2835	POLD1 Antibody [A14M15]
F3623	POLD3 Antibody [E13B7]
F2171	POLG Antibody [M21J18]	DNA Polymerase γ,POLG
S3505	Polidocanol	Polidocanol (Polyoxyethylene lauryl ether, Polyoxyethyleneglycol Dodecyl Ether, Brij30, Laureth-23, Varithena) is a sclerosant used for treating uncomplicated spider veins and reticular veins in the lower extremities.
S1074	Poliumoside	Poliumoside exhibits significant inhibition of advanced glycation end product formation with IC50 values of 19.69 µM. In the rat lens aldose reductase assay.Poliumoside exhibits greater inhibitory effects on rat lens aldose reductase(RLAR) with IC50 values of 8.47 µM.
S5893	Poloxin	Poloxin is a non-ATP competitive Polo-like Kinase 1 polo-box domain (Plk1 PBD) inhibitor with an apparent IC50 of 4.8 μM. Poloxin's IC50 values against the PBDs of Plk2 and Plk3 as Plk1 are approximately 4-fold and 11-fold higher, respectively in fluorescence polarization assays.
E6541	PolQi2	PolQi2 is a PolΘ inhibitor that specifically targets the N-terminal helicase domain of PolΘ, thereby suppressing alt-EJ (alternative end-joining) repair. This compound improves the accuracy and integration efficiency of gene editing across multiple loci and diverse cell lines. Additionally, PolQi2 demonstrates synergistic effects with DNA-PK inhibitors in reducing Cas9-mediated off-target activity. Its application is suitable for gene editing studies.
F1239	POLR3A Antibody [E12G4]
E4026	Poly(2-hydroxyethyl methacrylate)	Poly(2-hydroxyethyl methacrylate) is one of the most important hydrogels in the world of biomaterials. It is the basic component of contact lenses and is also used in the implantation of soft tissues, synthetic transplant for gristle and bone, regeneration of neurotic tissue, transmission of agents, etc.
E2904	Poly(vinyl alcohol)	Poly(vinyl alcohol) is an artificial polymer that is used in many industries, such as textile, paper industry, and food packaging industry due to its high chemical and thermal stability. Poly(vinyl alcohol) is also an excellent source for fiber, polymer, textile, surface, organic.
E4024	Poly-D-lysine hydrobromide	Poly-D-lysine hydrobromide is a synthetic polymeric substrate most widely used in neural cell culture. It removes proteinase K-resistant PrP from prion-infected SN56 neuroblastoma cells without affecting PrPC.
F0957	Poly/Mono-ADP Ribose Antibody [A22J18]	Poly (ADP-Ribose) Polymer,Poly/Mono-ADP Ribose
E1299	Polybrene (Hexadimethrine Bromide)	Polybrene (Hexadimethrine bromide) is a cationic polymer which is widely used as supplement for retroviral and lentiviral transduction.
E7055	Polydatin	Polydatin is a natural potent stilbenoid polyphenol and a resveratrol derivative with improved bioavailability. Polydatin exhibits diverse biological effects primarily by influencing key signaling pathways linked to inflammation, oxidative stress, and programmed cell death. By regulating multiple inflammatory mediators, polydatin demonstrates strong anti-inflammatory potential, while simultaneously activating antioxidant defenses and inhibiting oxidative mechanisms across a range of pathological conditions.
E4019	Polyethylenimine	Polyethylenimine (PEI) is a hydrophilic cationic polymer that acts as a low toxicity and efficient gene vector.
E3309	Polygala Fallax Hemsl. Rhizome Extract	Polygala Fallax Hemsl. Rhizome Extract is drawed from the rhizome of Polygala Fallax Hemsl., which has effects on immune function, such as anti-stress, anti-inflammatory, blood activating, lipid regulating, and in vitro inhibition of hepatitis B virus.
S9386	Polygalacic acid	Polygalacic acid is the triterpenoid tetrahydroxyacid isolated from Polygala paenea L.. Polygalacic acid (0-100 μM; 24 hours) significantly decreases the mRNAexpressions of MMP-3, MMP-9, MMP-13 and COX-2, which are significantly increased by IL-1β, in a dose-dependent manner.
S9241	Polygalaxanthone III	Polygalaxanthone III is a natural product with the efficacy of tranquilization, glaangal, eliminating sputum and detumescence. Polygalaxanthone III inhibits chlorzoxazone 6-hydroxylation catalyzed by CYP2E1 with an IC50 of 50.56 μM.
S9238	Polygalic acid	Polygalic acid (Senegenic acid), a triterpenoid saponin, shows expectorant, emetic and stimulant effects.
E3844	Polygonatum Odoratum Extract	Polygonatum Odoratum Extract is extracted from Polygonatum odoratum, which inhibits high glucose-induced tubular epithelial cell apoptosis and reduces oxidative stress.
E3257	Polygoni Multiflori Root Extract	Polygoni Multiflori Root Extract is extrcated from the roots of Polygoni Multiflori, which is used for treating tuberculosis that has spread to the lymph nodes, cancer, inflammation of the prostate (prostatitis), and constipation.
E3064	Polygonum Aviculare Extract	Polygonum Aviculare Extract is obtained from Polygonum Aviculare, has strong inhibitory effects on cell proliferation and induces apoptotic cell death in the MCF-7 breast cancer cells.
E3299	Polygonum Cuspidatum Extract	Polygonum Cuspidatum Extract is extracted from Reynoutria japonica Houtt.
E3561	Polygonum fagopyrum seed Extract	Polygonum Fagopyrum Seed Extract is extracted from the seed of Fagopyrum esculentum.
E3401	Polygonum hydropiper Extract	Polygonum hydropiper Extract is extracted from Polygonum hydropiper, which has protective effects against gastric injury through antioxidant and anti-inflammatory pathways.
E0518	Polyinosinic acid-polycytidylic acid	Polyinosinic acid-polycytidylic acid (Polyinosinic-polycytidylic acid; Poly(I:C)), a double-stranded RNA that induces innate immunity in mammals, is a candidate immunopotentiator for pharmaceuticals. Polyinosinic acid-polycytidylic acid is dsRNA formed by the long chain decomposition of muscle poly (I) homopolymer into poly (C) homopolymer.
E4998	Polyinosinic-polycytidylic acid sodium	Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic double-stranded RNA (dsRNA) analogue that activates the MDA-5 receptor in the cytoplasm and TLR3 in endosomal compartments. This activation promotes the production of type I interferons and induces apoptosis in cancer cells, particularly those that lack protective anti-apoptotic mechanisms like Bcl-xL.
E7258	Polymyxin B	Polymyxin B is an antibiotic. Polymyxin B inhibits Gram-negative infections by binding to the LPS of the bacterial wall with high affinity. Polymyxin B neutralizes the effect of endotoxin. Polymyxin B induces bacterial death by increasing its permeability. Polymyxin B is used in endotoxemia research.
E7958	Polymyxin B nonapeptide	Polymyxin B nonapeptide is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue. Polymyxin B nonapeptide is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes.
S1395	Polymyxin B sulphate	Polymyxin B (Aerosporin, PMB, Poly-RX) is an antibiotic primarily used for resistant gram-negative infections.
E8004	Polymyxin B1	Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment.
S3279	Polyphyllin B (Formosanin C)	Polyphyllin B (Formosanin C, FC), a diosgenin saponin isolated from Paris formosana, is an immunomodulator with antitumor activity. Polyphyllin B (Formosanin C, FC) induces apoptosis.
S9114	Polyphyllin I	Polyphyllin I, a small molecular monomer extracted from Rhizoma of Paris polyphyllin, is used in the treatment of infectious disease and cancer. Polyphyllin I inhibits proliferation and induces apoptotic cell death in U251 cells. Polyphyllin I is an activator of the JNK signaling pathway with a potential anti-glioma effect.
S9302	Polyphyllin VI	Polyphyllin VI derived from Paris polyphylla possess anti-cancer activities.
S9515	Polyphyllin VII	Polyphyllin VII (Y-0166), the the main member of polyphyllin family, shows strong anticancer activity against several carcinomas, including lung cancer, breast cancer, colorectal cancer, cervical cancer, hepatocellular carcinoma and osteosarcoma.
E3660	Polypodiodes niponica Extract	Polypodiodes Niponica Extract is extracted from Polypodiodes Niponica.
E0185	Polytetrafluoroethylene	Polytetrafluoroethylene (PTFE) is a biomedical material and has excellent non-stick properties with an exceptionally low coefficient of friction.
S6001	pomaglumetad (LY404039)	LY404039 is a potent agonist of recombinant human mGlu2/mGlu3 receptors with K_i of 149 nM/92 nM, shows >100-fold selectivity over ionotropic glutamate receptors, glutamate transporters, and other receptors. Phase 3.
S1567	Pomalidomide (CC-4047)	Pomalidomide inhibits LPS-induced TNF-α release with IC50 of 13 nM in PBMCs. Pomalidomide can be utilized in PROTAC as a ligand for targeting E3 ligase and inhibiting the E3 ligase protein cereblon (CRBN). Pomalidomide promotes apoptosis and cell cycle arrest.
E3643	Pomegranate Peel Extract	Pomegranate Peel Extract is extracted from the peel of Punica granatum L..
E3645	Pomegranate seed Extract	Pomegranate Seed Extract is extracted from the seed of Punica granatum.
E1028	POMHEX	POMHEX, is a potent ENO2 -specific inhibitor of enolase and a racemic mixture, a cell-permeable pivaloyloxymethyl (POM) prodrug of HEX. It is also glycolysis inhibitor and can be used for the research of cancer.
S9562	Pomolic acid	Pomolic acid is a pentacyclic triterpene isolated from Euscaphis japonica, and is highly effective in inhibiting cell growth and induces apoptosis.
F2376	PON1 Antibody [G1G1]
F3855	PON2 Antibody [K8P11]
S1490	Ponatinib	Ponatinib is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively. Ponatinib (AP24534) inhibits autophagy.
E7000	Ponatinib hydrochloride	Ponatinib hydrochloride is a potent, orally available multi-targeted inhibitor of Pan BCR-ABL kinase. It potently inhibits ABL with an IC50 of 0.37 nM, also inhibits SRC , VEGFR2, FGFR1, PDGFRα, LYN with an IC50s of 5.4 nM, 1.5 nM, 2.2 nM, 1.1 nM, 0.24 nM respectively and exhibits significant potential in cancer reserach.
E7180	Ponceau 4R	Ponceau 4R is a synthetic colorant that can be used for food coloring. Ponceau 4R is a strawberry red azo dye that can be used in a variety of foods, usually synthesized from aromatic hydrocarbons, and is stable to light, heat, and acids.
S4497	Ponceau S	Ponceau S (Acid Red 112) is the most commonly used stain for immunoblotting protocols. Ponceau S dye is applied as an acidic aqueous solution, and the proteins on the membrane are stained with red color.
S9165	Poncirin	Poncirin (Isosakuranetin-7-neohesperidoside), extracted from trifoliate orange, has anti-bacterial and anti-inflammatory activities.
S8241	Ponesimod	Ponesimod (ACT-128800) is an orally active, selective sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator with EC50 of 5.7 nM.
E3017	Poria Cocos Extract	Poria Cocos Extract is extracted from Poria cocos, which can stimulate aquaporin-3 via the PI3K/Akt/mTOR signaling pathway.
E0204	Poricoic acid A	Poricoic acid A is isolated from the surface layer of Poria cocos. Poricoic acid A activates AMPK to attenuate fibroblast activation and abnormal extracellular matrix remodelling in renal fibrosis. Poricoic acid A also is a modulator of tryptophan hydroxylase-1 (TPH-1).
S1257	Posaconazole	Posaconazole is an inhibitor primarily of CYP3A4, but it does not inhibit the activity of other CYP enzymes; Also an inhibitor of sterol C14ɑ demethylase inhibitor with IC50 of 0.25 μM. Posaconazole has a median terminal elimination half-life of 15-35 hours.
E2843	Poseltinib	Poseltinib (HM71224, LY3337641) shows a highly selective inhibition for Bruton’s tyrosine kinase (BTK) with IC50 of 1.95 nM, in which the selectivity toward other BMX, TEC and TXK are 0.3, 2.3 and 2.4 fold, respectively.
S4806	Potassium 1-Naphthaleneacetate	Potassium 1-Naphthaleneacetate (KANU, α-Naphthaleneacetic Acid Potassium Salt) is being studied as a synthetic growth factor that affects conidial germination, sporulation, mycelial growth, cell surface morphology, and the viability of certain fungal plant pathogens.
S4843	Potassium acetate	Potassium acetate (Diuretic salt, Potassium ethanoate) is the potassium salt of acetic acid, which is a synthetic carboxylic acid with antibacterial and antifungal properties.
E4470	Potassium Chloride	Potassium chloride is an inorganic salt commonly used in fertilizer industry. It is also extensively used as a potassium supplement.
E4465	Potassium clavulanate cellulose	Potassium clavulanate cellulose (Potassium clavulanate:cellulose (1:1)) is a mixture of potassium clavulanate and cellulose, is a bacterial β-lactamase inhibitor. Potassium clavulanate with the combination of amoxicillin can be used for the research of different infections caused by bacteria, such as sinusitis, pneumonia, ear infections, bronchitis, urinary tract infections, and infections of the skin.
E4002	Potassium D-gluconate	Potassium D-gluconate(Potassium Gluconate) is an orally active carboxylic acid by the oxidation with antiseptic and chelating properties.
S5799	Potassium guaiacolsulfonate hemihydrate	Potassium guaiacolsulfonate hemihydrate (Potassium Hydroxymethoxybenzenesulfonate, Sulfogaiacol) is used as an expectorant for relieving symptoms of cough and mucus in the chest due to respiratory infections, asthma, colds, or hay fever.
S1897	Potassium Iodide	Potassium Iodide is used to treat overactive thyroid and to protect the thyroid gland from the effects of radiation from inhaled or swallowed radioactive iodine.
E0353	Potassium oxonate	Potassium oxonate (Oxonic Acid Potassium Salt) is a selectively competitive uricase inhibitor, produced hyperuricemia (HUA) in rodents.
E0195	Potassium phosphate dibasic	Potassium phosphate dibasic (Dipotassium phosphate, K2HPO4) is often used as a fertilizer, food additive, and buffering agent.
E0166	Potassium phosphate monobasic	Potassium phosphate monobasic (Monopotassium phosphate) is a commonly used in biological assay buffers. Potassium phosphate monobasic is moderate to highly concentrated aqueous solutions of potassium phosphate monobasic for the production of phosphate buffers and other laboratory applications. Potassium phosphate monobasic (KH2PO4) also used as a fertilizer, food additive, and buffering agent.
S3142	Potassium sorbate	Potassium sorbate (Sorbic acid potassium) is a nonpoisonous food preservative isolated from Sorbus aucuparia. Potassium sorbate is an effective inhibitor of most molds and yeasts and some bacteria.
S6020	Potassium thioacetate	Potassium thioacetate is widely used as a sulfur source in the synthesis of sulfur-containing organic compounds. It has been employed for the synthesis of heterocycles, polymers, transition-metal ligands, nanoparticles, bioactive compounds and macromolecular inclusion complexes.
E4737	Potrasertib	Potrasertib (IMP7068, WEE1-IN-10) is a potent and selective inhibitor of WEE1 Kinase. It displays antitumor activity and is well-tolerated in patients with advanced solid tumors.
S4678	Povidone iodine	Povidone iodine (Betadine, PVP iodine, PVP-I, Isodine) is a stable chemical complex of polyvinylpyrrolidone (povidone, PVP) and elemental iodine. Povidone iodine displays excellent antibacterial activity against MRSA and MSSA strains with MICs of 31.25 mg/L and 7.82 mg/L, respectively. Povidone iodine is used as a topical antiseptic in surgery and for skin and mucous membrane infections, as well as as an aerosol.
S7358	Poziotinib	Poziotinib is an irreversible pan-HER inhibitor with IC50 of 3.2 nM, 5.3 nM and 23.5 nM for HER1, HER2, and HER4, respectively. Poziotinib also induces apoptosis and G1 cell cycle arrest. Phase 2.
S7060	PP1	PP1 (AGL 1872, EI 275) is a potent and selective Src inhibitor for Lck/Fyn with IC50 of 5 nM/ 6 nM.
S7008	PP2	PP2 (AG 1879, AGL 1879), a Src family kinase inhibitor, potently inhibits Lck/Fyn with IC50 of 4 nM/5 nM in cell-free assays, ~100-fold less potent to EGFR, inactive for ZAP-70, JAK2 and PKA.
F0645	PP2A A Subunit Antibody [P15H17]
A5255	PP2A alpha/beta Rabbit Recombinant mAb	PP2A alpha/beta Rabbit Recombinant mAb detects endogenous level of total PP2A alpha/beta.
F0794	PP2A B Subunit Antibody [F20H10]	PP2A B Subunit,PP2A-B55-α,PPP2R2A
F3812	PP2A C subunit Antibody [C1E4]
F0441	PP2A C Subunit Antibody [P20A19]	PP2A alpha + beta,PP2A C Subunit,PP2A-Cα/β
F1240	PP2C-α Antibody [L3F21]	PP2C-α,PPM1A
E7700	PPADS tetrasodium	PPADS tetrasodiuma is a non-selective P2X receptor antagonist. PPADS tetrasodiuma blocks recombinant P2X1, -2, -3, -5 with IC50s ranging from 1 to 2.6 μM. PPADS tetrasodiuma blocks native P2Y2-like (IC50~0.9 mM) and recombinant P2Y4 (IC50~15 mM) receptors. PPADS tetrasodiuma is an inhibitor of the reverse mode of the Na/Ca2+ exchanger in guinea pig airway smooth muscle.
F4266	PPARα Antibody [P17E1]
F3621	PPP1CA + PPP1CB Antibody [D19B4]
F2108	PPP1CB Antibody [P21B20]
A5359	PPP1R1A Rabbit Recombinant mAb	PPP1R1A Rabbit Recombinant mAb detects endogenous level of total PPP1R1A.
F3715	PPP2R5D Antibody [H6G7]
S0198	PPQ-102	PPQ-102 (CFTR Inhibitor IV) is a potent inhibitor of CFTR. PPQ-102 can completely inhibit CFTR chloride current with IC50 of ~90 nM.
S8003	PQ 401	PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.
S8784	PQR620	PQR620 is a novel, selective, orally bioavailable and brain penetrant dual TORC1/2 inhibitor. PQR620 has anti-tumor activity across 56 lymphoma models with a median IC50 of 250 nM after 72 h of exposure.
S7130	PR-619	PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM in a cell-free assay. PR-619 activates autophagy.
S1515	Pracinostat (SB939)	Pracinostat (SB939) is a potent pan-HDAC inhibitor with IC50 of 40-140 nM with exception for HDAC6. It has no activity against the class III isoenzyme SIRT I. Pracinostat (SB939) induces apoptosis in tumor cells. Phase 2.
E7561	Pradigastat	Pradigastat (LCQ-908) is a potent and selective inhibitor of DGAT1 with an IC50 of 57 nM in hDGAT1. It also inhibits OATP1B1, OATP1B3 , and OAT3 activity in a concentration-dependent manner, with an IC50 of 1.66 μM, 3.34 μM, and 0.973 μM, respectively.
S9315	Praeruptorin A	Praeruptorin A, a naturally existing pyranocumarin, is isolated from the dried root of Peucedanum praeruptorum Dunn. Praeruptorin A inhibits p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca2+ oscillation. Praeruptorin A can significantly upregulates multidrug resistance-associated protein 2 expression via the constitutive androstane receptor-mediated pathway in vitro, and this should be taken as an herb-drug interaction.
S9392	Praeruptorin B	Praeruptorin B is an important compound isolated from Bai-hua Qian-hu and has been reported to exert multiple biochemical and pharmacological activities.praeruptorin B exerts lipid-lowering effects through inhibits SREBPs and could serve as a possible therapeutic option to improve hyperlipidemia and hyperlipidemia-induced comorbidities.
S9151	Praeruptorin E	Praeruptorin E, isolated from Peucedanum praeruptorum Dunn., is a cardiotonic agent with selective cardiac calcium channel agonistic effect.
S1497	Pralatrexate	Pralatrexate is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines. Pralatrexate induces tumor cell apoptosis.
S4575	Pralidoxime chloride	Pralidoxime chloride (2-PAM) is an antidote to organophosphate pesticides and chemicals; An acetylcholinesterase (AChE) reactivator.
S5100	Pralidoxime Iodide	Pralidoxime Iodide (2-PAM) is an antidote approved for reactivation of inhibited acetylcholinesterase (AChE) in organophosphate poisoning.
S8716	Pralsetinib (BLU-667)	Pralsetinib (BLU-667, CS 3009, Gavreto) is a highly potent and selective RET (c-RET) inhibitor with an IC50 of 0.4 nM for WT RET. It also demonstrates potent activity (IC50 0.4 nmol/L) against common oncogenic RET alterations, including RET (M918T).
D4039	Praluzatamab ravtansine	Praluzatamab ravtansine (CX-2009) is a conditionally activated Probody drug conjugate (PDC) comprising an anti-CD166 mAb conjugated to DM4, with a protease-cleavable linker and a peptide mask that limits target engagement in normal tissue and circulation.
S2460	Pramipexole	Pramipexole (SND 919,Mirapexin,Sifrol,Mirapex) is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.
S2011	Pramipexole 2HCl Monohydrate	Pramipexole 2HCl Monohydrate is a novel non-ergoline dopamine (DA) agonist, used to treat Parkinson's disease.
S5066	Pramipexole dihydrochloride	Pramipexole dihydrochloride (SND919) is a dopamine agonist of the non-ergoline class indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS) with Ki values of 3.9 nM, 2.2 nM, 0.5 nM and 5.1 nM for D2S receptor, D2L receptor, D3 receptor and D4 receptor.
S2594	Pramiracetam	Pramiracetam (CI-879,Pramistar) is a more potent nootropic drug derived from piracetam.
P1063	Pramlintide Acetate	Pramlintide Acetate is a prescription drug that can lower blood sugar in people with diabetes.
S4092	Pramoxine HCl	Pramoxine(Pramocaine hydrochloride) is a topical local anesthetic that has been shown to have antipruritic properties.
S2436	Pranidipine	Pranidipine (Acalas, OPC 13340) is a new 1,4-dihydropyridine calcium channel blocker. Pranidipine can enhance cyclic GMP-independent nitric oxide-induced relaxation of the rat aorta.
S1829	Pranlukast	Pranlukast (ONO-1078,ono-rs-411) is an orally administered, and selective antagonist of the cysteinyl leukotrienes (LT) C(4), LTD(4) and LTE(4), used in the prophylactic treatment of chronic bronchial asthma.
E6047	Pranlukast hemihydrate	Pranlukast hemihydrate (ONO-1078 hemihydrate) is an antagonist of cysteinyl leukotriene receptor-1 (CysLT1) that blocks leukotrienes such as LTC4, LTD4, and LTE4, reducing bronchoconstriction and airway inflammation. It also inhibits NF-κB activation, thereby suppressing proinflammatory cytokine production (e.g., IL-6, IL-1, TNF-α) in monocytes/macrophages and T cells, contributing to its immunomodulatory effects.
S1960	Pranoprofen	Pranoprofen (Pyranoprofen,Pranopulin) is a non-steroidal COX inhibitor, used as an anti-inflammatory drug in ophthalmology.
F0239	PRAS40 Antibody [P22K6]
S1258	Prasugrel	Prasugrel (Effient, Efient, Prasita,CS-747, LY640315,PCR 4099) is a thienopyridine ADP receptor (P2Y12) antagonist, used for the reduction of thrombotic cardiovascular events.
S4637	Prasugrel Hydrochloride	Prasugrel hydrochloride (Prasugrel HCl, LY640315,PCR 4099 Hydrochloride) is a piperazine derivative and pletelet aggregation inhibitor that is used to prevent thrombosis in patients with acute coronary syndrome.
S5713	Pravastatin	Pravastatin(CS-514) is a lipoprotein-lowering drug via reversibly inhibiting hydroxymethylglutaryl-CoA (HMG-CoA) reductase and the synthesis of very-low-density lipoproteins.
S3036	Pravastatin sodium	Pravastatin sodium (CS-514) is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.
S1691	Praziquantel	Praziquantel is an anthelmintic effective against flatworms.
S5780	Prazosin	Prazosin is an α1-blocker that acts as an inverse agonist at alpha-1 adrenergic receptors. It is used to treat hypertension.
S1424	Prazosin HCl	Prazosin HCl (cp-12299-1) is a competitive alpha-1 adrenoceptor antagonist, used to treat high blood pressure or benign prostatic hyperplasia.
F2440	PRC1 Antibody [A3H10]
F3747	PRDM16 Antibody [P2E21]
A5448	PRDX1 Rabbit Recombinant mAb	PRDX1 Rabbit Recombinant mAb detects endogenous level of total PRDX1.
E5960	PRDX1-IN-1	PRDX1-IN-1 is a celastrol-ligustrazine hybrid and a potent inhibitor of peroxiredoxin 1 (PRDX1) with an IC50 of 0.164 μM. It induces ROS accumulation, inhibits cancer cell growth and metastasis, and exhibits strong antitumor efficacy, making it a promising candidate for lung cancer therapy.
A5292	PRDX6 Rabbit Recombinant mAb	PRDX6 Rabbit Recombinant mAb detects endogenous level of total PRDX6.
S6950	PRE-084 hydrochloride	PRE-084 hydrochloride (HCl) is a potent, selective sigma-1 receptor (σ1, S1R) agonist with IC50 of 44 nM in the sigma receptor assay.
A5893	Prealbumin Rabbit Recombinant mAb	Prealbumin Rabbit Recombinant mAb detects endogenous levels of total Prealbumin.
L3900	Preclinical/Clinical Compound Library	A unique collection of 3603 preclinical and clinical compounds for high throughput screening (HTS) and high content screening (HCS).
E0530	Prednicarbate	Prednicarbate (Dermatop) is a medium potency topical corticosteroid used to manage pruritus and inflammation associated with responsive skin conditions.
S1737	Prednisolone	Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
S2570	Prednisolone Acetate	Prednisolone Acetate (Omnipred,Prednisolone-21-acetate) is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant agent.
S5961	Prednisolone disodium phosphate	Prednisolone disodium phosphate (Hydeltrasol, Prednisolone 21-phosphate disodium) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties that exerts late mitogenic and biphasic effects on resistant acute lymphoblastic leukemia cells.
E6059	prednisolone hemisuccinate	Prednisolone hemisuccinate (Prednisolone 21-hemisuccinate) is a synthetic glucocorticoid with anti-inflammatory properties. It is used in the treatment of inner ear diseases and vertigo caused by vestibular hypofunction.
E6078	Prednisolone Tebutate	Prednisolone tebutate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester primarily used for its anti-inflammatory and immunosuppressive effects. It significantly suppresses inflammatory responses in models of monosodium urate (MSU) crystal-induced inflammation.
S1622	Prednisone	Prednisone is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.
S5489	Prednisone acetate	Prednisone acetate (Betapar, Cortan, Deltasone, Fernisone, Meticorten, Prednisone 21-acetate) is a glucocorticoid steroid that can be used as a glucocorticoid receptor agonist with anti-inflammatory and immunomodulating properties.
S1914	Pregnenolone	Pregnenolone(3β-Hydroxy-5-pregnen-20-one) is an endogenous steroid hormone, used in the treatment of fatigue, Alzheimer’s disease, trauma and injuries.
E4945	Pregnenolone monosulfate sodium	Pregnenolone monosulfate sodium, a sodium salt form of pregnenolone monosulfate, is an active neurosteroid and a precursor of all steroid hormones. It functions act as a potent endogenous allosteric signal-specific inhibitor of CB1 receptors, reducing psychoactive effects associated with Δ9-tetrahydrocannabinol (THC).
E8260	Pregnenolone-d4	Pregnenolone-d4 is a deuterated form of Pregnenolone.Pregnenolone is an endogenous steroid hormone.
S6910	Preladenant	Preladenant (Privadenant, SCH 420814, MK-3814) is a potent, competitive and selective antagonist of the human adenosine A_2A receptor with Ki of 1.1 nM.
F0755	Presenilin 1 Antibody [G5E7]	Presenilin 1,Presenilin 1/PS-1,Presenilin-1
F3873	Presenilin 1/PS-1 Antibody [G24D17]
F1375	Presenilin 2 Antibody [P6E5]	Presenilin 2,Presenilin 2/AD5
S1162	Pretomanid (PA-824)	PA-824 is an anti-tuberculosis drug for tuberculosis with MIC less than 2.8 μM.Phase 2.
S6385	Prexasertib (LY2606368)	Prexasertib (LY2606368, ACR 368) is a selective ATP competitor inhibitor of Chk1 and Chk2 with IC50s of 1 nM and 8 nM in cell-free assays, respectively. Prexasertib also inhibits RSK1 with an IC50 of 9 nM in cell-free assay.
S7178	Prexasertib HCl (LY2606368)	Prexasertib(LY2606368) is an ATP-competitive CHK1 inhibitor with a Ki value of 0.9 nmol/L. For CHK2 and RSK, its IC50 values are 8 nM and 9 nM respectively in cell-free assay.
E1538	PRGL493	PRGL493 is a potent and selective inhibitor of long-chain acyl-CoA synthetase 4 (ACSL4). PRGL493 blocks cell proliferation and tumor growth in both breast and prostate cellular and animal models. PRGL493 is used for cancer research.
E1258	Pridopidine	Pridopidine (ACR16, ASP2314, FR310826) , a dopamine (DA) stabilizer, acts as an antagonist against sigma 1 receptor (S1R) and dopamine D2 receptor (D2R).
S1619	Prilocaine	Prilocaine (NSC 40027) is a local anesthetic of the amino amide type. It acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation.
S5482	Prilocaine hydrochloride	Prilocaine hydrochloride is the hydrochloride salt form of prilocaine, which is a local anesthetic.
S9029	Prim-o-glucosylcimifugin	Prim-O-glucosylcimifugin (Cimifugin beta-D-glucopyranoside, Cimifugin 7-glucoside) is a major constituent in Radix Saposhnikovia that has been long used for the treatment of pyrexia, rheumatism, and cancer in traditional Chinese medicine. It shows potential anticancer activity. Prim-O-glucosylcimifugin downregulates the mRNA and protein expression inducible NO synthase (iNOS) and cyclooxygenase 2 (COX-2) in LPS-activated RAW 264.7 macrophages in a concentration-dependent manner.
S7723	PRIMA-1	PRIMA-1 (2,2-Bis(hydroxymethyl)-3-quinuclidinone) is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.
E6014	Primaquine	Primaquine, an 8-aminoquinoline, is an antimalarial agent and a potent gametocytocidal in falciparum malaria. It also prevents relapse in vivax and ovale malaria.
S4237	Primaquine Diphosphate	Primaquine Diphosphate is a transmission-blocking anti-malarial clinically available, displaying a marked activity against gametocytes of all species of human malaria.
S1965	Primidone	Primidone (NCI-C56360) is an anticonvulsant of the pyrimidinedione class.
E3054	Primula Malacoides Extract	Primula Malacoides Extract is drawed from Primula Malacoides herb (Primulaceae).
E7672	Prinaberel	Prinaberel (ERB-041) is a potent and selective estrogen receptor (ER) β agonist with IC50s of 5.4, 3.1 and 3.7 nM for human, rat and mouse ERβ, respectively. Prinaberel displays >200-fold selectivity for ERβ over ERα. Prinaberel is a potent skin cancer chemopreventive agent that acts by dampening the WNT/β-catenin signaling pathway. Prinaberel induces ovarian cancer apoptosis.
F2115	Prion Antibody [B8A2]	Prion Protein,Prion protein PrP,PRNP
A5436	Prion Protein Rabbit Recombinant mAb	Prion Protein Rabbit Recombinant mAb detects endogenous level of total Prion Protein.
E0198	Pristane	Pristane (2,6,10,14-Tetramethylpentadecane, TMPD) is a natural saturated terpenoid alkane obtained primarily from shark liver oil that is widely used to induce tumorgenesis in mice and arthritis and lupus nephritis in rats. Pristane can be used to induce animal models of Systemic Lupus Erythematosus.
S9404	Pristimerin	Pristimerin is a naturally occurring triterpenoid that has been shown to suppress the proliferation of various cancer cell lines at the concentration (IC50) range of 0.2-4 μM, including those of breast, glioma, prostate, pancreatic, ovarian, colon. Pristimerin can inhibits monoacylglycerol lipase(MGL) with an IC50 of 93 nM through a reversible mechanism.
E7997	Pristinamycin IA	Pristinamycin IA (Mikamycin B) is a cycle-peptidic macrolactone antibiotic. Pristinamycin IA is a substrate of P-glycoprotein and inhibits its function. Pristinamycin IA is active against StaphyloEoccus and Srreptococcus.
S7546	Pritelivir (BAY 57-1293)	Pritelivir (BAY 57-1293, AIC316) is a potent helicase primase inhibitor, exhibiting antiviral effect on herpes simplex virus (HSV) with IC50 of 20 nM for both HSV-1 and HSV-2.
F3987	PRKACG Antibody [H19A15]
F2039	PRKAR2B Antibody [L21D1]
E0140	PRL-3 Inhibitor (Compound 5e)	PRL-3 Inhibitor (Compound 5e) is a potent PRL-3 inhibitor with an IC50 of 0.9 μM.
F2422	PRMT1 Antibody [B18H13]	PRMT1
A5774	PRMT1 Rabbit Recombinant mAb	PRMT1 Rabbit Recombinant mAb detects endogenous levels of total PRMT1.
F1009	PRMT5 Antibody [N4N24]	Protein arginine N-methyltransferase 5, PRMT5, 72 kDa ICln-binding protein, Histone-arginine N-methyltransferase PRMT5, Jak-binding protein 1 Shk1 kinase-binding protein 1 homolog, SKB1 homolog, SKB1Hs, PRMT5, HRMT1L5, IBP72, JBP1, SKB1
F1966	PRMT6 Antibody [H12B3]
F1295	PRMT7 Antibody [H13L7]
S9944	PRN1008	PRN1008 (Rilzabrutinib) is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK), with an IC50 of 1.3 nM.
S8578	PRN1371	PRN1371 is an irreversible covalent FGFR1-4 kinase inhibitor, with IC50s of 0.6, 1.3, 4.1, 19.3 and 8.1 nM for FGFR1, 2, 3, 4 and CSF1R, respectively.
A5667	Pro Caspase 7 Rabbit Recombinant mAb	Pro Caspase 7 Rabbit Recombinant mAb detects endogenous level of total Pro Caspase 7.
F1715	pro Caspase3 Antibody [H9J6]
F1623	pro NGF Antibody [J14K17]
S5105	Proanthocyanidins	Proanthocyanidins (PAs), also known as condensed tannins, are a class of polyphenols found in a variety of plants. They are very powerful antioxidants that remove harmful free oxygen radicals from cells.
S4022	Probenecid	Probenecid (Benemid) is a classical competitive inhibitor of organic anion transport, which is also a TRPV2 agonist and an inhibitor of TAS2R16. Probenecid is also a clinically used broad-spectrum Pannexin1 (Panx1) blocker.
S2119	Probucol	Probucol (DH-581) is an anti-hyperlipidemic drug by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.
E7106	Procainamide	Procainamide (Procaine amide) is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1), which reactivates the expression of tumor suppressor factors by demethylating tumor suppressor genes. Procainamide induces vacuolization in various cell types and reduces cell proliferation and migration. Procainamide relaxes airway smooth muscle by activating potassium channels. Procainamide can be used in cancer and arrhythmia research.
S4294	Procainamide HCl	Procainamide HCl is a sodium channel blocker, and also a DNA methyltransferase inhibitor, used in the treatment of cardiac arrhythmias.
S4023	Procaine HCl	Procaine (Novocaine) is an inhibitor of sodium channel, NMDA receptor and nAChR with IC50 of 60 μM, 0.296 mM and 45.5 μM, which is also an inhibitor of 5-HT3 with K_D of 1.7 μM.
S4979	Procaine penicillin G	Penicillin G Procaine (PGP, Penicillin G Procaine, Bicillin C-R), a crystalline complex combining penicillin G with procaine, is a β-lactam antibiotic.
S1995	Procarbazine HCl	Procarbazine HCl (NSC-77213) is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound, used for the treatment of Hodgkin's lymphoma.
S2083	Procaterol HCl	Procaterol HCl (OPC-2009) is a short-acting β2-adrenergic receptor agonist with K_p of 8 nM, used for the treatment of asthma
E3877	Processed Cyperus Extract	Processed Cyperus Extract is extracted from Cyperus rotundus Lin., which is used in the treatment of stomach disorders and emotional disturbances.
S4631	Prochlorperazine dimaleate salt	Prochlorperazine dimaleate salt is a dopamine (D2) receptor antagonist.
S4408	Procodazole	Procodazole (Propazol, 2-Benzimidazolepropionic acid, 3-(1H-benzimidazole-2) propanoic acid) is used as a potentiator which is non-specific active immunoprotective against viral and bacterial infections.
E8023	Proctolin	Proctolin is an endogenous pentapeptide that acts as an excitatory neuromodulator.
E0240	Procyanidin B1	Procyanidin B1, a natural polyphenolic compound that has antioxidant properties, inhibits Kv10.1 channel and suppresses the evolution of hepatoma.
S3290	Procyanidin B2 (PCB2)	Procyanidin B2 (PCB2), a natural flavonoid found in commonly consumed foods, possess anti-inflammatory, anti-oxidant and anti-cancer activities. Procyanidin B2 activates PPARγ to induce M2 polarization in mouse macrophages. Procyanidin B2 significantly suppresses the activation of NLRP3 inflammasome in the lung tissue induced by paraquat in the rat model.
E0478	Procyanidin C1	Procyanidin C1 is a polyphenolic component of grape seed extract, increases the healthspan and lifespan of mice through its action on senescent cells. PCC1 is a natural senotherapeutic agent with in vivo activity and a potential intervention to delay, alleviate or prevent age-related pathologies.
S8233	Prodigiosin	Prodigiosin is a natural red pigment produced by numerous bacterial species which can inhibit Wnt/β-catenin pathway.
F2974	Profilin 1 Antibody [M2C23]	Profilin 1,Profilin-1
S5776	Proflavine	Proflavine (3,6-Diaminoacridine) is a disinfectant bacteriostatic against many gram-positive bacteria. It is a topical antiseptic used mainly in wound dressings.
S4236	Proflavine Hemisulfate	Proflavine Hemisulfate is a topical antiseptic by interchelating DNA, thereby disrupting DNA synthesis and leading to high levels of mutation in the copied DNA strands.
S1705	Progesterone	Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. A potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM; An agonist of the membrane progesterone receptors(mPRs); An antagonist of the σ1 receptor.
F0452	Progesterone Receptor A/B Antibody [E5B3]	Progesterone Receptor A/B
F0809	Progesterone Receptor B Antibody [B13J21]
E8259	progesterone-d9	Progesterone-d9 is a deuterated form of progesterone.Progesterone is an endogenous steroid hormone that is involved in regulating the menstrual cycle, pregnancy, and embryonic development in humans and other species.
S5927	Proguanil	Proguanil (chlorguanide, chloroguanide) is a prophylactic antimalarial drug. It inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for DNA synthesis and cell multiplication.
S3082	Proguanil HCl(Atovaquone)	Proguanil hydrochloride(Chloroguanil, Chlorguanide hydrochloride), an antimalarial proagent acts as an inhibitor of dihydrofolate reductase (DHFR). Proguanil acts as a biguanide to enhance the Atovaquone effect.
F2433	Prohibitin Antibody [A14G6]	PHB1,Prohibitin
A5237	Prohibitin Rabbit Recombinant mAb	Prohibitin Rabbit Recombinant mAb detects endogenous level of prohibitin.
S5622	Prohydrojasmon	Prohydrojasmon is a newly launched plant growth regulator, which has jasmonic acid activity.
E7155	Prolylleucine	Prolylleucine is a dipeptide containing branched-chain amino acids. Prolylleucine can affect the circadian rhythms and behaviour of animals.
S5428	Promazine hydrochloride	Promazine (Romtiazin, Sinophenin) is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors with antipsychotic effects.
S3657	Promestriene	Promestriene (3-propyl ethyl, 17B-methyl estradiol) is a synthetic estrogen analog that has been reported to significantly improve the symptoms of vaginal atrophy caused by estrogen deprivation in topical application.
S5196	Promethazine	Promethazine is a potent histamine H1 receptor antagonist. Promethazine is a medication used in the management and treatment of allergic conditions, nausea and vomiting, motion sickness, and sedation. Promethazine exhibits antiparasitic properties.
S4293	Promethazine HCl	Promethazine HCl is a potent histamine H₁ receptor antagonist, used as a sedative and antiallergic medication.
E7048	Pronase E (Activity ≥ 4000 U/mg)	Pronase E (Activity ≥ 4000 U/mg) is a mixture of proteolytic enzymes that is obtained from Streptomyces griseus and could digest protein into individual amino acids.
E8154	Pronase E (Activity ≥ 7000 U/g)	PronaseE(Activity:7000/g) is a protease derived from Streptomyces griseus, known for its L-amino acid oxidase activity. It is used to enhance flavor development in dry fermented sausages.
S4867	Propacetamol hydrochloride	Propacetamol hydrochloride (PRO) is a water-soluble prodrug of paracetamol (PA) which can be parenterally administered as analgesic for the treatment of postoperative pain, acute trauma, and gastric and/or intestinal disorders.
S5789	Propafenone	Propafenone (SA-79) is an orally active sodium channel blocking agent and a beta-adrenoceptor (β-adrenergic receptor) antagonist. Propafenone offers a broad spectrum of activity in the treatment of cardiac arrhythmias.Propafenone can be used to induce animal models of Heart Failure.
S2500	Propafenone HCl	Propafenone HCl is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias.Propafenone HCl can be used to induce animal models of Heart Failure.
E8225	propane-d6-1,3-diol	Propane-d6-1,3-diol is the deuterated form of 1,3-propanediol。1,3-Propanediol is produced by microorganisms through the fermentation of glycerol.
S4834	Propantheline bromide	Propantheline bromide (Pro-Banthine, Neometantyl, Neopepulsan) is a muscarinic antagonist used to treat gastrointestinal conditions associated with intestinal spasm and to decrease secretions during anesthesia.
S1828	Proparacaine HCl	Proparacaine HCl(Proxymetacaine Hydrochloride) is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.
E7867	Propargyl-C1-NHS ester	Propargyl-C1-NHS ester is a nonclaevable linker for antibody-agent-conjugation (ADC). Propargyl-C1-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
E8079	Propargyl-PEG1-acid	Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs Ibrutinib(HY-10997)-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM. Propargyl-PEG1-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
S0655	Propargyl-PEG4-NHS ester	Propargyl-PEG4-NHS ester is a 4-unit amine reactive PEG linker for antibody-drug-conjugation (ADC) which is noncleavable.
S6874	Propidium Iodide	Propidium iodide (PI) is a red-fluorescent DNA stain which penetrates only damaged cellular membranes. Propidium iodide (PI) is described for use in the determination of cell viability in cell suspension.
E2869	Propiolactone	Propiolactone(β-Propiolactone), a sterilizing and sporicidal agent, is used to sterilize blood plasma, vaccines, tissue grafts, surgical instruments and enzymes.
E4808	Propionyl-L-carnitine hydrochloride	Propionyl-L-carnitine hydrochloride(Levocarnitine propionate hydrochloride) supports mitochondrial metabolism, offers cardiovascular benefits, acts as a free radical scavenger, and is used in treating colonic inflammatory bowel disease.
S4931	Propiverine hydrochloride	Propiverine is an anticholinergic drug used for the treatment of overactive bladder and urinary incontinence. Propiverine is a muscarinic receptor antagonist possessing additional properties, i.e., block of L-type Ca2+ channels.
E5827	Propranolol	Propranolol is a non-selective antagonist of β-adrenergic receptors (βAR), with Ki values of 1.8 nM for β1AR and 0.8 nM for β2AR, effectively lowering cAMP levels and activating the MAPK pathway downstream of βARs. It is an effective treatment for infantile hemangiomas (IHs), where it induces antiproliferative and antisurvival effects on hemangioma stem cells (HemSCs).
S4076	Propranolol HCl	Propranolol HCl (AY-64043, ICI-45520, NCS-91523) is a competitive non-selective beta-adrenergic receptors inhibitor.
S5113	Propyl gallate	Propyl gallate (Gallic acid propyl esterZ, n-Propyl gallate) is an antioxidant used in foods especially animal fats and vegetable oils, also in a wide variety of cosmetics and beauty care products.
E0940	Propyl pyrazole triol (PPT)	Propyl pyrazole triol (PPT) is a selective estrogen receptor alpha (ERα) agonist.
S5405	Propylparaben	Propylparaben (Propyl 4-hydroxybenzoate, Propyl p-hydroxybenzoate, nipasol), a natural substance found in many plants and some insects, is an antimicrobial, preservative and flavouring agent.
S1988	Propylthiouracil	Propylthiouracil (NSC 6498, NSC 70461) is a thyroperoxidase and 5'-deiodinase inhibitor, used to treat hyperthyroidism.
S5309	Propyphenazone (4-Isopropylantipyrine)	Propyphenazone(4-Isopropylantipyrine, Isopropyrine), an analgesic and antipyretic agent, is a selective cyclooxygenase-2 inhibitor with anti-inflammatory activity.
F2844	Prostaglandin D Synthase (Lipocalin)/PDS Antibody [A1L2]
F2783	Prostaglandin E Receptor EP2/PTGER2 Antibody [L20C8]
S3003	Prostaglandin E2 (PGE2)	Prostaglandin E2 (PGE2, Dinoprostone) plays important effects in labour (softens cervix and causes uterine contraction) and also stimulates osteoblasts to release factors that stimulate bone resorption by osteoclasts. It is easy to discolor when stored in liquid environment for a long time. It is recommended to store it in powder form and try to use it as soon as possible!
F4988	Prostate Specific Membrane Antigen Antibody [A11C13]
F2479	Prosurfactant Protein C Antibody [N9F13]	Prosurfactant Protein C,Prosurfactant Protein C (proSP-C),surfactant protein c/SP-C
S9672	PROTAC SGK3 degrader-1	PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a PROTAC conjugate of the 308-R SGK inhibitor with the VH032 VHL binding ligand, targeting SGK3 (Serum/Glucocorticoid Regulated Kinase Family Member 3) for degradation.
E1894	PROTAC tubulin-Degrader-1(compound W13)	PROTAC tubulin-Degrader-1(compound W13) is an inhibitor of PROTAC tubulin exhibiting antitumor activity against human lung cancer.
P1169	Protamine sulfate	Protamine sulfate is a polycationic, highly positively charged protein derived from salmon sperm protein, used to neutralize unfractionated heparin administration (UFH)-induced anticoagulation following cardiovascular surgical procedures.
L2500	Protease Inhibitor Library	A unique collection of 454 small molecule inhibitors used for chemical genomics, high-throughput screening (HTS), and high content screening (HCS).
E7137	Protease-Activated Receptor-2, amide	Protease-Activated Receptor-2, amide (SLIGKV-NH2) is a highly potent protease-activated receptor-2 (PAR2) activating peptide.
A5852	Proteasome 19S S5A Rabbit Recombinant mAb	PSMD4 Rabbit Recombinant mAb detects endogenous levels of total PSMD4
A5844	Proteasome 20S C2 Rabbit Recombinant mAb	Proteasome 20S C2 Rabbit Recombinant mAb detects endogenous levels of total Proteasome 20S C2
A5835	Proteasome 20S LMP2 Rabbit Recombinant mAb	Proteasome 20S LMP2 Rabbit Recombinant mAb detects endogenous levels of total Proteasome 20S LMP2
F3699	Proteasome 20S LMP7 Antibody [N6D20]	Proteasome 20S LMP7,PSMB8/LMP7
B23201	Protein A/G Magnetic Beads for IP
B23202	Protein A/G Magnetic Beads for IP
F2405	Protein CASP Antibody [J23N1]
E7445	Protein Kinase C (19-31)	Protein Kinase C (19-31), a peptide inhibitor of protein kinase C (PKC), derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31), is used as protein kinase C substrate peptide for testing the protein kinase C activity.
L8100	Protein-protein Interaction Inhibitor Library	A unique collection of 407 protein-protein Interaction(PPI) Inhibitors used for high throughput screening(HTS) and high content screening(HCS).
P1242	Proteinase K	Proteinase K is a serine endoprotease, is used for isolating amyloid cores and is effective over a wide pH range (4–12), including in the presence of SDS or urea. It is commonly used as a preparative reagent for destruction of proteins, including DNAses and RNAses, in DNA and RNA preparations.
S1881	Protionamide	Protionamide (Prothionamide, 1321-TH) is a drug used in the treatment of tuberculosis.
S3975	Protocatechuic acid	Protocatechuic acid (PCA, 3,4-Dihydroxybenzoic acid, Protocatechuate), a dihydroxybenzoic acid, is a type of widely distributed naturally occurring phenolic acid.
E1746	Protokylol hydrochloride	Protokylol hydrochloride(Caytine hydrochloride, JB-251 hydrochloride) is a salt form of protokylol and is an agonist of β-adrenergic receptor. Protokylol hydrochloride is also used as a bronchodilator.
S3883	Protopine	Protopine (Corydinine, Fumarine, Biflorine, Macleyine), an alkaloid present in different plants, has been shown to exhibit a number of activities, such as inhibition of calcium influx through both voltage and receptor-operated channels and inhibition of rabbit blood platelet aggregation. It also possesses anti-cholinergic and anti-histaminic as well as anti-bacterial activities.
S5145	Protoporphyrin IX (PPIX)	Protoporphyrin IX (PPIX) is a heterocyclic organic compound, which consists of four pyrrole rings, and is the final intermediate in the heme biosynthetic pathway.
S7880	Protoporphyrin IX Zinc	Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an potent, orally active and competitive heme oxygenase-1 (HO-1) inhibitor and significantly reduces the protective effects of Phloroglucinol (PG) against hydrogen peroxide.This product has poor solubility, animal experiments are available, cell experiments please choose carefully!
S9243	Protosappanin B	Protosappanin B (FT-0689654, Q-100961), extracted from Lignum Sappan, possesses anti-inflammation and anti-oxidation properties.
S9510	Protriptyline hydrochloride	Protriptyline Hydrochloride is the hydrochloride salt form of protriptyline. Protriptyline is a tricyclic secondary amine with antidepressant property which acts by inhibition of serotonin and norepinephrine reuptake.
F2796	PROX1 Antibody [E13N19]	Prox 1,PROX1
S4932	Proxyphylline	Proxyphylline (Monophylline, Spasmolysin) is a derivative of theophylline which is used as a bronchodilator and for its cardiovascular properties. It selectively antagonizes A1 adenosine receptors (Ki = 82 nM for bovine brain) versus A2 adenosine receptors (Ki = 850 µM for platelets).
A5335	PRP19 Rabbit Recombinant mAb	PRP19 Rabbit Recombinant mAb detects endogenous level of total PRP19.
E8145	PRT-060318	PRT-060318 (PRT318) is a novel selective inhibitor of the tyrosine kinase Syk with an IC50 of 4 nM.
S7738	PRT-060318 2HCl	PRT-060318 (PRT318) is a novel selective inhibitor of the Syk tyrosine kinase with an IC50 of 4 nM, as an approach to HIT treatment.
E7793	PRT062607	PRT062607 is a highly specific, potent and orally bioavailable inhibitor of purified Spleen tyrosine kinase (SYK) with an IC50 of 1-2 nM. It exhibits significant anti-inflammatory activity and can be used in non-Hodgkin lymphoma (NHL), chronic lymphocytic leukemia (CLL) and rheumatoid arthritis research.
S8032	PRT062607 (P505-15) HCl	PRT062607 (P505-15, BIIB057, PRT-2607) HCl is a novel, highly selective Syk inhibitor with IC50 of 1 nM in cell-free assays, >80-fold selective for Syk than Fgr, PAK5, Lyn, FAK, Pyk2, FLT3, MLK1 and Zap70.
S5315	PRT4165	PRT4165 is a Bmi1/Ring1A inhibitor with an IC50 of 3.9 µM in the cell-free assay and also inhibits PRC1-mediated H2A ubiquitylation in vivo and in vitro.
E1658	PRT543	PRT543 is a potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) with broad antitumor activity in vitro and in vivo. It also inhibits the methyltransferase activity of the PRMT5/MEP50 complex with an IC50 of 10.8 nM.
S2875	Prucalopride	Prucalopride (R-93877) is a selective, high affinity 5-HT receptor agonist for 5-HT4A and 5-HT4B receptor with K_i of 2.5 nM and 8 nM, respectively, exhibits >290-fold selectivity against other 5-HT receptor subtypes.
S4247	Prucalopride Succinate	Prucalopride(R-108512) is a selective, high affinity 5-HT4 receptor agonist. The Ki values of prucalopride for human 5-HT(4a) and 5-HT(4b) receptor are 2.5 nM and 8 nM, respectively.
S2071	Prulifloxacin (NM441)	Prulifloxacin (NM441, AF 3013), the prodrug of ulifloxacin, is a broad-spectrum oral fluoroquinolone antibacterial agent.
E3744	Prunella Vulgaris Extract	Prunella Vulgaris Extract is obtained from Prunella vulgaris, which is a medicinal herb that has been used for centuries to treat infections and other illnesses
E3676	Prunus cerasus Extract	Prunus cerasus Extract is extracted from Prunus cerasus.
E3212	Prunus Humilis Bunge Extract	Prunus Humilis Bunge Extract is extracted from Prunus Humilis Bunge, which is a potential antioxidant.
E3661	Prunus persica Extract	Prunus persica Extract is extracted from Prunus persica.
E3830	Prunus Serrulata Extract	Prunus Serrulata Extract is extracted from Prunus serrulata, which has antioxidant and natural antiviral agents.
S8010	PRX-08066 Maleic acid	PRX-08066 Maleic acid is a selective 5-HT2B receptor antagonist with IC50 of 3.4 nM, prevents the severity of pulmonary arterial hypertension in the MCT rat model. Phase 2.
S7691	PS-1145	PS-1145 is a specific IKK inhibitor with IC50 of 88 nM.
S7586	PS-48	PS-48 is an allosteric activator of phosphoinositide-dependent protein kinase-1 (PDK1).
S3462	PS210	PS210 is a potent activator of PDK1 that binds to the PIF-pocket and allosterically modulates the active site of PDK1.
E2816	PS47	PS47 is an inactive E isomer of PS48, an activator of 3-Phosphoinositide-dependent protein kinase 1 (PDPK1).
F4660	PSA/KLK3 Antibody [M14P16]
E7808	PSB-603	PSB-603 is a potent and highly selective A2B adenosine receptor antagonist exhibiting a Ki value of 0.553 nM and virtually no affinity for the human and rat A1 and A2A and the human A3 receptors up to a concentration of 10 μM.
F3124	PSD-95 Antibody [H11A14]	Post Synaptic Density Protein 95,PSD95,PSD-95
A5823	PSD93 Rabbit Recombinant mAb	PSD93 Rabbit Recombinant mAb detects endogenous levels of total PSD93
F0240	PSD95 Antibody [F17C8]	Post Synaptic Density Protein 95,PSD95,PSD-95
E0831	Pseudocoptisine chloride	Pseudocoptisine chloride (Isocoptisine chloride) is a quaternary alkaloid with benzylisoquinoline skeleton isolated from Corydalis Tuber, inhibits acetylcholinesterase (AChE) activity with an IC50 of 12.8 μM, showing anti-inflammatory and anti-amnestic effects.
S9199	Pseudoginsenoside F11	Pseudoginsenoside F11, a natural product found in American ginseng but not in Asian ginseng, is a novel partial PPARγ agonist.
E0249	Pseudolaric Acid A	Pseudolaric acid A, a Hsp90 inhibitor with an IC50 of 0.60 μM, 2.72 μM, 1.36 μM, 2.92 μM and 6.16 μM in HL-60, A549, SMMC-7721, HeLa and SW480 cells respectively, is the main bioactive ingredient in Pseudolarix cortex, and induces cell cycle arrest at G2/M phase and promotes cell death through caspase-8/caspase-3 pathway, demonstrating potent antiproliferation and anticancer activities.
S5373	Pseudolaric Acid B	Pseudolaric Acid B, a natural diterpenoid compound isolated from the root and trunk bark of Pseudolaric kaempferi Gordon, has anti-fungal and anti-fertility properties.
E8064	Pseudomonas quinolone signal	Pseudomonas Quinolone Signal (Compound C), a signaling molecule produced by Pseudomonas aeruginosa, can activate lasB. Pseudomonas Quinolone Signal can be used in the study of virulence regulation in Pseudomonas aeruginosa.
S9067	Pseudoprotodioscin	Pseudoprotodioscin is a steroidal saponin from plants and exhibits anti-inflammatory and anticancer activities. Pseudoprotodioscin inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides.
E3682	Pseudostellaria heterophylla Extract	Pseudostellaria Heterophylla Extract is extracted from Pseudostellaria Heterophylla, which has antitumor effect.
E4356	Pseudotropine	Pseudotropine(3β-Tropanol, ψ-Tropine) is an alkaloid and a plant metabolite of the tropane tropinone that has been found in A. belladonna. It is used in the preparation of novel nicotinic receptor agonists.
F3447	PSF1 Antibody [E5F3]
S5307	PSI-6206 (GS-331007)	PSI-6206 (RO-2433, GS-331007) is a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase, targeting NS5B polymerase.
E7545	PSI-7409	PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977). Sofosbuvir (PSI-7977) is a selective and highly active nucleotide analog inhibitor of HCV.
E3185	Psidium Guajava Extract	Psidium Guajava Extract is extracted from Psidium Guajava, which has been used in treatment of diabetes mellitus, cardiovascular diseases, cancer, and parasitic infections.
F1010	PSMA Antibody [N17H9]	Prostate Specific Membrane Antigen,PSMA,PSMA (FOLH1)
F2843	PSMB10/MECL1 Antibody [D18D5]
F1421	PSMB5 Antibody [F16L3]	PSMB5,PSMB5/MB1
F1514	PSMB6 Antibody [P14M13]
F1296	PSMD11 Antibody [L2N1]
F1105	PSMD14 Antibody [D2B20]	PSMD14 Rabbit mAb recognizes endogenous levels of total PSMD14 protein.
F4741	PSMD14 Antibody [G24K15]
S4737	Psoralen	Psoralen (Psoralene, Ficusin, Furocoumarin) is a naturally occurring furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division.
F2123	Psoriasin Antibody [L12L3]	Psoriasin,S100A7,S100A7/Psoriasin
E3805	Psyllium Husk Extract	Psyllium Husk Extract is derived from the seed husk of Plantago ovata Forsk, which has a long history of use as a dietary fiber supplement to promote the regulation of large bowel function, and more recently it has been shown to lower blood cholesterol levels.
E5952	PT 3	PT 3 is a benzamide-class, potent, and selective inhibitor of Histone Deacetylase 3 (HDAC3) with an IC50 of 245 nM. It crosses the blood-brain barrier and enhances learning and memory in novel object recognition models in mice.
E1937	PT-179	PT-179, an orthogonal Thalidomide derivative targets cereblon without causing off-target degradation effects. PT-179 specifically binds CRBN, forms a ternary complex with a target protein fused to a zinc finger (ZF) degron, and mediates the degradation of the tagged protein.
S8352	PT2385	PT2385 is a HIF-2α antagonist with luciferase EC50 of 27 nM and no significant off-target activity.
S8351	PT2399	PT2399 is a potent and orally available antagonist of HIF-2 that selectively disrupts the heterodimerization of HIF-2α with HIF-1β.
F2575	PTBP1 Antibody [P20K3]
A5539	PTBP2 Rabbit Recombinant mAb	PTBP2 Rabbit Recombinant mAb detects endogenous level of total PTBP2.
S7372	PTC-209	PTC-209 is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM in HEK293T cell line, and results in irreversible reduction of cancer-initiating cells (CICs).
F2641	PTCH1 Antibody [K3H23]	Patched / PTCH1,PTCH1
F3548	PTEN Antibody [J22G2]
S3937	Pterostilbene	Pterostilbene is a natural dietary compound and the primary antioxidant component of blueberries. It has been implicated in anticarcinogenesis, modulation of neurological disease, anti-inflammation, attenuation of vascular disease, and amelioration of diabetes.
S0924	Pteryxin	Pteryxin ((+)-Pteryxin), a dihydropyranocoumarin derivative found in Apiaceae family, is a potent inhibitor of butyrylcholinesterase (BChE) with IC50 of 12.96 μg/ml. Pteryxin inhibits LPS-induced nitric oxide production in mouse peritoneal macrophages with IC50 of 20 µM. Pteryxin is potential for Alzheimer's disease (AD) treatment.
E0791	PTGR2-IN-1	PTGR2-IN-1 is a potent prostaglandin reductase 2 (PTGR2) inhibitor with an IC50 of ~0.7 μM.
F3430	PTN Antibody [B1M21]
S3696	PTP Inhibitor I	PTP Inhibitor I is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor with Ki values of 43 and 42 μM for SHP-1(ΔSH2) and PTP1B, respectively.
S3678	PTP Inhibitor II	PTP Inhibitor II (NSC 129010, 4-(Bromoacetyl)anisole) is a cell-permeable protein tyrosine phosphatase (PTP) inhibitor that covalently binds the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with Ki value of 128 μM.
F0954	PTP-PEST Antibody [A18N23]
A5695	PTP1B Rabbit Recombinant mAb	PTP1B Rabbit Recombinant mAb detects endogenous level of total PTP1B.
E7629	PTP1B-IN-1	PTP1B-IN-1 (Compound 7a) is a small molecule inhibitor of PTP1B with an IC50 value of 1.6 mM. It is often used as the mother core for derivatives of analogues.
S0119	PTP1B-IN-2	PTP1B-IN-2 (MDK3465, Ptp1B-In-2, Compound P6) is a potent and selective protein tyrosine phosphatase-1B (PTP1B) inhibitor with IC50 of 50 nM. PTP1B-IN-2 enhances insulin-mediated insulin receptor β (IRβ) phosphorylation and insulin-stimulated glucose uptake.
E3545	Pu-erh tea Extract	Pu-erh tea Extract is the aqueous extract Pu-erh tea, which can alleviate the intestinal inflammation caused by antibiotics, reduce the degree of intestinal lesions, promote the growth of intestinal probiotics and inhibit pathogenic bacteria.
F0442	PU.1 Antibody [B4N6]	PU.1,PU.1/Spi1
A5533	PU.1/Spi1 Rabbit Recombinant mAb	PU.1/Spi1 Rabbit Recombinant mAb detects endogenous level of total PU.1/Spi1.
E5829	PU139	PU139 is a potent inhibitor of pan-histone acetyltransferase (HAT) that blocks Gcn5, PCAF, CBP, and p300 with IC50 values of 8.39 μM, 9.74 μM, 2.49 μM, and 5.35 μM, respectively. It significantly impairs Smp14 promoter activity, suggesting that targeting SmGCN5 and SmCBP1 is a novel strategy to control S. mansoni egg development, it also exhibits anticancer activity.
E3225	Pueraria Flower Extract	Pueraria Flower Extract is extracted from Pueraria lobata（Willd.）Ohwi.
E3224	Puerariae Lobatae Radix Extract	Puerariae Lobatae Radix Extract, which is extracted from Puerariae Lobatae Radix, has antioxidant properties.
S2346	Puerarin	Puerarin (Kakonein), an isoflavones found in the root of Radix puerariae, is a 5-HT2C receptor and benzodiazepine site antagonist.
E3455	Puff-ball Extract	Puff-Ball Extract is extracted from Calvatia, which has inhibitory effects on the proliferation of breast cancer cells through apoptosis.
S9271	Pulchinenoside A	Pulchinenoside A (Anemoside A3), a natural triterpenoid saponin, is a AMPARs and NMDAR modulator.
S9140	Pulegone	Pulegone, a naturally occurring organic compound, is a fragrance and flavour ingredient.pulegone stimulates both TRPM8 and TRPA1 channel in chicken sensory neurons and suppresses the former but not the latter at high concentrations.
S0356	Pulrodemstat (CC-90011) besylate	Pulrodemstat (CC-90011) besylate (LSD1-IN-7 benzenesulfonate) is a potent and orally active lysine specific demethylase-1 (LSD1) inhibitor that is found to be effective in various tumors.
S9308	Pulsatilla saponin D	Pulsatilla saponin D (SB365), isolated from the root of Pulsatilla koreana, targets c-Met and exerts antiangiogenic and antitumor activities.
E3033	Pulsatillae Extract	Pulsatillae Extract is extracted from Pulsatilla chinensis, major active constituent of which can reduce tumorigenesis, metastasis and immunosuppression of tumor via disruption of the MAPK signaling pathway.
F0558	Puma Antibody [L23F7]	Puma,PUMAα/β
F4191	Puma Antibody [L5K18]
F2990	Pumilio 1 Antibody [N12C17]
E3513	Pumpkin seed Extract	Pumpkin Seed Extract is extracted from the seeds of Cucurbita, which can be used to treat lower urinary tract symptoms.
S9131	Punicalagin	Punicalagin, a major ellagitannin found in pomegranate extracts, has been shown to have antioxidant, anti-inflammatory, and anticancer effects., Punicalagin, a major ellagitannin found in pomegranate extracts, has been shown to have antioxidant, anti-inflammatory, and anticancer effects.
S6359	Purine	Purine is a heterocyclic aromatic organic compound which plays crucial roles in DNA and RNA. It is also significant components in a number of other important biomolecules, such as ATP, GTP, cyclic AMP, NADH, and coenzyme A.
S3042	Purmorphamine	Purmorphamine (Shh Signaling Antagonist VI), which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo with IC50 of ~ 1.5 μM in HEK293T cell and also is an inducer of osteoblast differentiation with EC50 of 1 μM. Purmorphamine can reduce both basal and induced autophagy.
E4996	Puromycin	Puromycin (CL13900, Puromycine) is an antibiotic, analog of the 3' end of aminoacyl-tRNA and an inhibitor of protein synthesis that mimics tyrosyl-tRNA, causing premature termination of translation. It blocks translation by labeling and releasing elongating polypeptide chains from ribosomes and has been widely used in molecular biology research.
S9631	Puromycin aminonucleoside	Puromycin aminonucleoside (NSC 3056, PAN, Stylomycin aminonucleoside, ARDMA, SAN), the aminonucleoside portion of the antibiotic puromycin, is a reversible inhibitor of dipeptidyl-peptidase II and cytosol alanyl aminopeptidase that induces apoptosis in mesangial cells (MCs) accompanied by declined cell viability and enhanced inflammatory response.Puromycin aminonucleoside can be used to induce animal models of Kidney Disease.
S7417	Puromycin Dihydrochloride	Puromycin 2HCl is an aminonucleoside antibiotic derived from Streptomyces alboniger. It is an inhibitor of protein synthesis and has been used to study transcription regulatory mechanisms that control the sequential and coordinated expression of genes during cell differentiation.
E3897	Purple Perilla Seed Extract	Purple Perilla Seed Extract is extracted from the seeds of Perilla frutescens L. Britt., which supports muscle synthesis and exercise performance.
S4963	Purpurin	Purpurin (1,2,4-Trihydroxyanthraquinone, Hydroxylizaric acid, Verantin) is one of the natural colorants extracted from madder roots and other Rubiaceae family plants. It exhibits anti-angiogenic, antifungal, antibiotic, and antioxidative activities. Purpurin strongly inhibits the activities of CYP1A1, CYP1A2 and CYP1B1.
E7081	Purpurin 18	Purpurin-18 is a chlorophyll-derived dihydroporphyrin, serves as a key precursor for photosensitizers like purpurinimides, which absorb light in the 700–850 nm range. It demonstrate potent photodynamic anti-tumor activity and generates ROS, disrupting mitochondrial membrane potential and inducing apoptosis against triple-negative breast cancer both in vitro and in vivo.
E7926	Purpurogallin	Purpurogallin is a naturally phenol extracted from the plants of Quercus spp, has potent xanthine oxidase (XO) inhibitory activity with an IC50 of 0.2 µM. Purpurogallin has antioxidant and anti-inflammatory effects.
E3456	Purslane Extract	Purslane Extract is extracted from Portulaca oleracea, which possesses anti-inflammatory and antioxidant activities.
S7793	Purvalanol A	Purvalanol A is a potent, and cell-permeable CDK inhibitor with IC50 of 4 nM, 70 nM, 35 nM, and 850 nM for cdc2-cyclin B, cdk2-cyclin A, cdk2-cyclin E, and cdk4-cyclin D1, respectively. Purvalanol A induces endoplasmic reticulum stress-mediated apoptosis and autophagy.
S0500	Purvalanol B	Purvalanol B (NG-95) is a potent and selective inhibitor of cyclin-dependent kinase (CDK) with IC50 of 6 nM, 6 nM, 9 nM and 6 nM for cdc2-cyclin B, CDK2-cyclin A, CDK2-cyclin E and CDK5-p35, respectively.
S3596	PVP (Polyvinylpyrrolidone)	PVP (Polyvinylpyrrolidone) is an inert, water-soluble, non-toxic, temperature-resistant, pH-stable, biocompatible, biodegradable polymer that helps to encapsulate and cater both hydrophilic and lipophilic drugs. Polyvinylpyrrolidone has been widely tested and used as an effective wound healing accelerator.
F4102	PVR/CD155 Antibody [D7N14]
S7947	PX-12	PX-12 (DB05448, 1-methyl propyl 2-imidazolyl disulfide) is a potent thioredoxin-1 (Trx-1) inhibitor by irreversibly thioalkylation of Cys73 of Trx-1. Phase 2.
S7612	PX-478 2HCl	PX-478 2HCl is an orally active, and selective hypoxia-inducible factor-1α (HIF-1α) inhibitor. PX-478 2HCl induces apoptosis and has anti-tumor activity. Phase 1.
S9861	PY-60	PY-60 is a small-molecule activator of the transcriptional coactivator Yes-associated protein (YAP) with EC50 of 1.6 µM, which acts by inhibiting a central scaffolding protein in the Hippo pathway, Annexin A2. It promotes the regenerative repair of cutaneous wounds in pig and human models.
E3063	Pygeum Topengii Bark Extract	Pygeum Topengii Bark Extract is extracted from the bark of Pygeum Topengii, which helps with prostate and kidney health and general inflammation.
A5495	Pygopus 2 Rabbit Recombinant mAb	Pygopus 2 Rabbit Recombinant mAb detects endogenous level of total Pygopus 2.
F1208	PYK2 Antibody [L4N9]	Pyk2
E7393	Pymetrozine	Pymetrozine is a feeding inhibitor of Homoptera, in preventing transmission of cauliflower mosaic caulimovirus by the aphid species Myzus persicae (Sulzer).
E4633	Pyocyanin	Pyocyanin（Pyocyanine; Sanazin; Sanasin) is a redox-active toxin produced by Pseudomonas aeruginosa that generates oxidative stress and selectively harms quorum sensing (QS)-defective mutant bacteria. It acts as a social policing agent, promoting the survival of QS-proficient and more virulent bacterial populations.
S7129	PYR-41	PYR-41 is the first cell-permeable inhibitor of ubiquitin-activating enzyme E1, with no activity at E2. PYR-41 induce apoptosis.
E7635	Pyr10	Pyr10 is a pyrazole derivative and a selective TRP cation 3 (TRPC3) inhibitor. Pyr10 inhibits Ca2+ influx in carbachol-stimulated TRPC3-transfected HEK293 cells with an IC50 of 0.72 μM (IC50 of 13.08 μM for store operated Ca2+ entry in BRL-2H3 cells). Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels.
E4659	Pyr3	Pyr3 is a selective and potent inhibitor of transient receptor potential canonical channel 3 (TRPC3). It inhibits TRPC3-mediated Ca2+ influx in a dose-dependent manner with the IC50 value of 0.7 μM. It holds potential for treating TRPC3-related diseases like cardiac hypertrophy.
E8027	Pyr6	Pyr6 is a selective inhibitor of TRPC3 with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells).IC50 value: 0.49 uM Target: TRPC3 inhibitorPyr6 is a selective SOCE inhibitor (Yonetoku et al., 2008; Sweeney et al., 2009), Pyr6 displayed 37-fold (1.58 OM) higher potency for RBL SOCE than for TRPC3 ROCE, with an IC50 comparable to that of Pyr2 and Pyr3. Pyr6 at 3 uM diminished TRPC3 currents to only 52%. Consistent with inhibition of Orai channel activity Pyr2, Pyr3 or Pyr6 substantially inhibited typical Orai downstream signalling events in RBL mast cells (NFAT activation and degranulation) activated by passive store depletion.
E7441	Pyranine	Pyranine (HPTS; Solvent Green 7) is a pH-sensitive fluorescent indicator. Pyranine acts as a class of fluorescent chemosensor for the Cu+ ion(λex=450 nm, λem=510 nm).
S2501	Pyrantel Pamoate	Pyrantel pamoate (Pyrantel Embonate), a broad-spectrum anthelmintic drug, is used to treat a number of parasitic worm infections.
S1762	Pyrazinamide	Pyrazinamide (Pyrazinoic Acid Amide) is an agent used to treat tuberculosis.
S3093	Pyrazole	Pyrazole (1H-pyrazole) is a five membered heteroaromatic ring with two nitrogen atoms is of immense significance. Pyrazole is an indispensable anchor for design and development of new pharmacological agents.
E7442	Pyrazosulfuron-ethyl	Pyrazosulfuron-ethyl, one of the acetolactate synthase inhibiting herbicides in the sulphonylurea family, has been widely used to control weed growth in commercial cereal, soybean, and vegetable fields.
E3095	Pyrethrum Extract	Pyrethrum Extract is extracted from Pyrethrum, which can induce apoptosis in HCT cells, and therefore, it can be used as a novel therapeutic for colorectal cancer treatment.
E8140	Pyridoclax	Pyridoclax is a potential Mcl-1 inhibitor.
S6789	Pyridone 6	Pyridone 6 is a pan-JAK inhibitor with IC50s of 1 nM, 1 nM, 5 nM and 15 nM for JAK2, TYK2, JAK3 and JAK1, respectively.
E8172	Pyridostatin	Pyridostatin (RR82) is a highly selective small molecule that stabilizes telomeric DNA G-quadruplex with a Kd of 490 nM, promoting their folding and inducing dysfunctional telomeres by uncapping POT1 and activating DNA damage signaling. It also modulates gene expression, reducing SRC protein levels and SRC-dependent motility in breast cancer cells, contributing to its anti-proliferative effects.
S7444	Pyridostatin Trifluoroacetate Salt	Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with K_d of 490 nM in a cell-free assay, which targets a series of proto-oncogenes.
S1608	Pyridostigmine Bromide	Pyridostigmine Bromide is a parasympathomimetic and a reversible cholinesterase inhibitor.
S4871	Pyridoxal 5-phosphate monohydrate	Pyridoxal 5-phosphate monohydrate is an active vitamin B6 metabolite, which is a cofactor in many reactions of amino acid metabolism.
S6115	Pyridoxal 5′-phosphate hydrate	Pyridoxal 5′-phosphate (pyridoxal phosphate, Vitamin B6 phosphate, PAL-P, PLP), a vitamin B6 phosphate, is a coenzyme in a variety of enzymatic reactions. Pyridoxal 5′-phosphate at concentrations < 0.5 mM inhibits of polymerization deoxynucleoside triphosphate catalysed by variety of DNA polymerases isolated from type C RNA tumor viruses. The combination of Pyridoxal 5′-phosphate and NEIL2 will make NEIL2 completely lose its ability to bind damaged DNA.
S3111	Pyridoxal hydrochloride	Pyridoxal hydrochloride (HQ) is an active endogenous metabolite.
E7606	Pyridoxal isonicotinoyl hydrazone	Pyridoxal isonicotinoyl hydrazone (PIH) is a lipophilic, tridentate Fe-chelating agent that shows high Fe chelation efficacy.
S5311	Pyridoxal phosphate	Pyridoxal phosphate (Pyridoxal 5'-phosphate, PAL-P, PLP, Vitamin B6), the active form of vitamin B6, acts as a coenzyme in all transamination reactions, and in certain decarboxylation, deamination, and racemization reactions of amino acids.
S3980	Pyridoxine	Pyridoxine (Pyridoxol, Vitamin B6, Gravidox), also known as vitamin B6, is a form of vitamin B6 found commonly in food and used as dietary supplement. It is a cofactor for both glutamic acid decarboxylase and GABA transaminase.
S3113	Pyridoxine HCl	Pyridoxine HCl (Vitamin B6,Pyridoxol hydrochloride) is a form of vitamin B6.
E7601	Pyridoxylamine	Pyridoxylamine is an advanced glycation end production (AGEs) and lipoxidation end products (ALEs) inhibitor, to protect against diabetes-induced retinal vascular lesions.
S4382	Pyrilamine Maleate	Pyrilamine Maleate (Mepyramine)is a histamine H1 receptor inverse agonist, it binds to a G protein-coupled form of the receptor and promotes a G protein-coupled inactive state of the H1 receptor that interferes with the Gq/11-mediated signaling.
E0608	Pyrilutamide(KX-826)	Pyrilutamide (KX-826) is an antagonist of androgen receptor (AR) and a potential first-in-class topical drug for the treatment of androgenetic alopecia (AGA) and acne vulgaris.
S2006	Pyrimethamine	Pyrimethamine(RP 4753) is a dihydrofolate reductase (DHFR) inhibitor, used as an antimalarial drug.
E4265	Pyrimidine	Pyrimidine is an endogenous metabolite. It is used to study the photoinduced ion chemistry of the halogenated pyrimidines, a class of prototype radiosensitizing molecules, and is also used to assess pyrimidine/purine asymmetry quantitatively.
E0462	Pyrintegrin	Pyrintegrin is an β1-integrin agonist and a 2,4-disubstituted pyrimidine that promotes embryonic stem cells survival, also enhances cell-extracellular matrix (ECM) adhesion-mediated integrin signaling.
S5798	Pyriproxyfen	Pyriproxyfen (S-31183) is an insect growth regulator that has been widely used worldwide as a larvicide in vector control and in agriculture to fight a very large number of pests.
E1774	Pyrithione	Pyrithione, a Transition metal complexe, is a zinc ionophore that causes increased zinc levels within mammalian cells. Pyrithione has potent bactericidal and anti-fungal activity.
S5141	Pyrithioxin	Pyrithioxin (Bonifen, Encefabol, Pyritinol, Vitamin B6 disulfide) is a neurotropic agent which reduces permeability of blood-brain barrier to phosphate. It has no vitamin B6 activity.
S4730	Pyrithioxin Dihydrochloride	Pyrithioxin (Bonifen, Encefabol, Pyritinol, Vitamin B6 disulfide) Dihydrochloride is a neurotropic agent which reduces permeability of blood-brain barrier to phosphate with no vitamin B6 activity.
S3885	Pyrogallol	Pyrogallol (1,2,3-trihydroxybenzene), an organic compound belonging to the phenol family, used as a photographic film developer and in the preparation of other chemicals. It is known to be a superoxide anion generator and ROS inducer.
E3435	Pyrola herb Extract	Pyrola Herb Extract is extracted from Pyrola, which can be used as an alternative therapeutic agent for postmenopausal osteoporosis.
E7970	Pyronaridine	Pyronaridine is a lipophilic Mannich base with potent antimalarial and potential antiviral activities. It inhibits haemozoin formation in Plasmodium by binding haematin, leading to parasite death. Pyronaridine is also active against P. falciparum and has shown efficacy against Echinococcus granulosus infections.
E7812	Pyronaridine tetraphosphate	Pyronaridine tetraphosphate is an orally active Mannich base anti-malarial agent. Pyronaridine tetraphosphate is active against P. falciparum and Echinococcus granulosus infection.
E4451	Pyronin Y	Pyronin Y is a fluorescent probe which stains double stranded RNA in living or fixed cells as well as in tissues.
L7400	Pyroptosis Compound Library	A unique collection of 751 pyroptosis related compounds used for high throughput screening(HTS) and high content screening(HCS).
S8852	Pyrotinib dimaleate	Pyrotinib dimaleate is a potent and selective irreversible dual tyrosine kinase inhibitor of EGFR and HER2 with IC50 of 0.013 μM and 0.038 μM, respectively.
S2190	Pyroxamide (NSC 696085)	Pyroxamide(NSC 696085) is a potent inhibitor of affinity-purified HDAC1 with ID50 of 100 nM. It also induces growth suppression and cell death in human rhabdomyosarcoma in vitro.
S5832	Pyrrole-2-carboxylic acid	Pyrrole-2-carboxylic acid (2-Pyrrolecarboxylic acid) is a degradation product of sialic acids and a derivative of the oxidation of the D-hydroxyproline isomers by mammalian D-amino acid oxidase.
S3578	Pyrroloquinoline quinone	Pyrroloquinoline quinone (PQQ, Methoxatin) is a natural anti-oxidant with anti-oxidative and anti-aging effects. Pyrroloquinoline quinone prevents estrogen deficiency-induced osteoporosis.Pyrroloquinoline quinone can alleviate allergic airway inflammation in mice by improving the immune microenvironment and regulating the JAK-STAT signaling pathway. This product has poor solubility, animal experiments are available, cell experiments please choose carefully!
S5263	Pyrroloquinoline Quinone Disodium Salt	Pyrroloquinoline quinone (methoxatin disodium salt), an aromatic tricyclic o-quinone, is a redox cofactor for bacterial dehydrogenases. It is an efficient electron transfer catalyst from a number of organic substrates to molecular oxygen (O2), constructing quinoprotein model reactions.
E3647	Pyrrosiae Folium Extract	Pyrrosiae Folium Extract is extracted from Pyrrosiae Folium.
A5503	Pyruvate Dehydrogenase E1 beta subunit Rabbit Recombinant mAb	Pyruvate Dehydrogenase E1 Rabbit Recombinant mAb detects endogenous level of total Pyruvate Dehydrogenase E1.
F1657	Pyruvate dehydrogenase E2/E3bp Antibody [P23D24]
S3143	Pyruvic acid	Pyruvic acid (Acetylformic acid) is an important organic chemical intermediate that plays a role in cardiomyocyte pathophysiology and therapy. Pyruvic acid markedly increases the level of lactate dehydrogenase (LDH) and creatine kinase (CK) and reduces the level of Ca²⁺Mg²⁺-ATPase and Na⁺K⁺-ATPase.
S5816	Pyrvinium pamoate	Pyrvinium pamoate(Pyrvinium embonate) is an anthelmintic effective for pinworms.
E7952	PYZD-4409	PYZD-4409 is a potent and specific small molecule inhibitor of the ubiquitin-activating enzyme UBA1 (E1) with an IC50 of 20 μM. It induces cell death in malignant cells and preferentially inhibits the clonogenic growth of primary acute myeloid leukemia cells and can be used as a research for developing treatments for hematologic malignancies.
S0798	PZ-2891	PZ-2891 is a selective, orally active and brain-penetrant pantothenate kinase (PANK) modulator that acts as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations. PZ-2891 inhibits PANK with IC50 of 40.2 nM, 0.7 nM and 1.3 nM for hPANK1β, hPANK2, and hPANK3, respectively.
E5989	PZL-A	PZL-A is a activator of mitochondrial DNA (mtDNA) synthesis. PZL-A restores wild-type-like activity to mutant forms of polymerase γ (POLγ) with 160 nM for A467T and 20 nM for G848S. In cellular systems, PZL-A stimulates mtDNA synthesis, promoting oxidative phosphorylation complex biogenesis and improving cellular respiration. PZL-A is promising agent for relieving POLG disease and other severe conditions linked to depletion of mtDNA.
E7546	PZM21	PZM21 is a potent and selective μ opioid receptor agonist with an EC50 of 1.8 nM.
E7448	[Pyr1]-Apelin-13	[Pyr1]-Apelin-13 is one of the endogenous agonists of the APJ receptor with high binding affinity Kd of 4.5 nM for hAPJ, predominantly found in the myocardium and plasma. It exhibits analgesic effects and improves cardiovascular function, making it a promising candidate for neuropathic pain and heart failure research.
E2898	ε-poly-L-lysine HCl	ε-poly-L-lysine (ε-PL) is a naturally occurring poly(amino acid), which possesses excellent antimicrobial activity and has been widely used in food and pharmaceutical industries.This product is very susceptible to moisture, please keep it sealed!